Auditory- Event Related Potentials in Multiple Sclerosis-A Systematic Review

Abstract

This systematic review aims to systematically review the research articles onevent-related potentials in individuals with multiple sclerosis (MS). The study used adetailed exploration of the major databases (e.g. Pubmed Central, Scopus, J Gate and Science Direct,) to archive the objectives of the systematic review. The retrieved articles were assessed in two stages: title and abstract screening, followed by a full-length article review. Twenty eight articles were selected after the full length review out of 40 shortlisted articles. Multiple sclerosis (MS) is an auto immune, demyelinating disease of the central nervous system. The demyelination process of the disease in the central nervous system can occur at any point in time which can exhibit various symptom. The disease usually presents with unilateral sensorineural hearing loss with sudden onset and fluctuating in nature (Atula et al., 2016; Fischer et al., 1985; Hellmann et al., 2011; Stach et al., 1990). Tinnitus and hearing loss are predominant symptoms of multiple sclerosis (Fischer etal., 1985). Cognitive impairment in MS was reported to have a varying prevalence ofabout 45% to 70% (Benedict et al., 2006; Kujala et al., 1997). Rate of information processing, attention, verbal fluency, and recent memory is the most impaired domains of cognition (Ivica et al., 2013). Working memory and information processing speed (IPS) are the most frequently impaired areas in MS, followed by learning, memory, and executive functions (Benedict et al., 2006; Rao et al., 1991; Sanfilipo et al., 2006). Therefore it is important to assess cognition, memory using Objective test (ERP) in individuals with multiple sclerosis.