FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Spierer, L
De Lucia, M
Bernasconi, F
Grivel, J
Bourquin, NMP
Clarke, S
Murray, MM
AF Spierer, Lucas
De Lucia, Marzia
Bernasconi, Fosco
Grivel, Jeremy
Bourquin, Nathalie M-P
Clarke, Stephanie
Murray, Micah M.
TI Learning-induced plasticity in human audition: Objects, time, and space
SO HEARING RESEARCH
LA English
DT Article
ID HUMAN AUDITORY-CORTEX; TEMPORAL-ORDER JUDGMENT; TRANSCRANIAL MAGNETIC
STIMULATION; PRIMATE PREFRONTAL CORTEX; MISMATCH NEGATIVITY MMN;
LONG-TERM-MEMORY; SOUND-LOCALIZATION; ENVIRONMENTAL SOUNDS; HEMISPHERIC
LESIONS; SPATIAL LOCATION
AB The human auditory system is comprised of specialized but interacting anatomic and functional pathways encoding object, spatial, and temporal information. We review how learning-induced plasticity manifests along these pathways and to what extent there are common mechanisms subserving such plasticity. A first series of experiments establishes a temporal hierarchy along which sounds of objects are discriminated along basic to fine-grained categorical boundaries and learned representations. A widespread network of temporal and (pre)frontal brain regions contributes to object discrimination via recursive processing. Learning-induced plasticity typically manifested as repetition suppression within a common set of brain regions. A second series considered how the temporal sequence of sound sources is represented. We show that lateralized responsiveness during the initial encoding phase of pairs of auditory spatial stimuli is critical for their accurate ordered perception. Finally, we consider how spatial representations are formed and modified through training-induced learning. A population-based model of spatial processing is supported wherein temporal and parietal structures interact in the encoding of relative and absolute spatial information over the initial similar to 300 ms post-stimulus onset. Collectively, these data provide insights into the functional organization of human audition and open directions for new developments in targeted diagnostic and neurorehabilitation strategies. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Spierer, Lucas; Bernasconi, Fosco; Bourquin, Nathalie M-P; Clarke, Stephanie; Murray, Micah M.] CHU Vaudois, Neuropsychol & Neurorehabil Serv, Dept Clin Neurosci, CH-1011 Lausanne, Switzerland.
[Spierer, Lucas; De Lucia, Marzia; Bernasconi, Fosco; Grivel, Jeremy; Bourquin, Nathalie M-P; Clarke, Stephanie; Murray, Micah M.] Univ Lausanne, Lausanne, Switzerland.
[De Lucia, Marzia; Murray, Micah M.] CHU Vaudois, Ctr Biomed Imaging, CH-1011 Lausanne, Switzerland.
[De Lucia, Marzia; Murray, Micah M.] CHU Vaudois, Dept Radiol, CH-1011 Lausanne, Switzerland.
[Grivel, Jeremy] CHU Vaudois, Community Psychiat Serv, CH-1011 Lausanne, Switzerland.
[Murray, Micah M.] Vanderbilt Univ, Dept Hearing & Speech Sci, Nashville, TN USA.
RP Murray, MM (reprint author), CHU Vaudois, Neuropsychol & Neurorehabil Serv, Dept Clin Neurosci, BH08-078,Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM micah.murray@chuv.ch
RI Spierer, Lucas/E-1771-2011; Centre d'imagerie Biomedicale,
CIBM/B-5740-2012
OI Spierer, Lucas/0000-0003-3558-4408;
FU Swiss National Science Foundation [K-33K1_122518/1, 3100A0-103895,
3100AO-118419]; Pierre Mercier Foundation for Science; Faculty of
Biology and Medicine of the Centre Hospitalier Universitaire Vaudois and
University of Lausanne; EEG Brain Mapping Core of the Center for
Biomedical Imaging (CIBM) of Geneva and Lausanne; Center for Biomedical
Imaging; University of Lausanne; Swiss Federal Institute of Technology,
Lausanne; University of Geneva; University Hospital Center, Lausanne;
University Hospital of Geneva; Jeantet Foundations
FX This work has been supported by grants from the Swiss National Science
Foundation (K-33K1_122518/1 to MDL; 3100A0-103895 to SC; 3100AO-118419
to MMM), a grant from the Pierre Mercier Foundation for Science (to IS
and JG), and en inter-disciplinary grant from the Faculty of Biology and
Medicine of the Centre Hospitalier Universitaire Vaudois and University
of Lausanne (to IS and JG). Analyses of EEG data were performed using
the Cartool software (http://brainmapping.unige.ch/cartool.htm) which is
developed by Denis Brunet from the Functional Brain Mapping Laboratory,
Geneva, Switzerland, and is supported by the EEG Brain Mapping Core of
the Center for Biomedical Imaging (CIBM) of Geneva and Lausanne. MRI and
fMRI data acquisition were supported by the Center for Biomedical
Imaging (http://www.cibm.ch), The University of Lausanne; The Swiss
Federal Institute of Technology, Lausanne; The University of Geneva; The
University Hospital Center, Lausanne; The University Hospital of Geneva;
and the Leenaards and the Jeantet Foundations.
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NR 162
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2011
VL 271
IS 1-2
SI SI
BP 88
EP 102
DI 10.1016/j.heares.2010.03.086
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 717VH
UT WOS:000287075000009
PM 20430070
ER
PT J
AU Steinschneider, M
Fishman, YI
AF Steinschneider, Mitchell
Fishman, Yonatan I.
TI Enhanced physiologic discriminability of stop consonants with prolonged
formant transitions in awake monkeys based on the tonotopic organization
of primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
ID DIFFERENT VOWEL ENVIRONMENTS; SPECTRAL TILT CHANGE; SPEECH-PERCEPTION;
LANGUAGE IMPAIRMENT; DEVELOPMENTAL DYSLEXIA; POPULATION RESPONSES; ONSET
SPECTRA; ACOUSTIC INVARIANCE; LEARNING-PROBLEMS; CHILDREN
AB Many children with specific language impairment (SLI) have difficulty in perceiving stop consonant-vowel syllables (e.g., /ba/, /ga/, /da/) with rapid formant transitions, but perform normally when formant transitions are extended in time. This influential observation has helped lead to the development of the auditory temporal processing hypothesis, which posits that SLI is causally related to the processing of rapidly changing sounds in aberrantly expanded windows of temporal integration. We tested a potential physiological basis for this observation by examining whether syllables varying in their consonant place of articulation (POA) with prolonged formant transitions would evoke better differentiated patterns of activation along the tonotopic axis of A1 in awake monkeys when compared to syllables with short formant transitions, especially for more prolonged windows of temporal integration. Amplitudes of multi-unit activity evoked by /ba/, /ga/, and /da/ were ranked according to predictions based on responses to tones centered at the spectral maxima of frication at syllable onset. Population responses representing consonant POA were predicted by the tone responses. Predictions were stronger for syllables with prolonged formant transitions, especially for longer windows of temporal integration. Relevance of findings to normal perception and that occurring in SLI are discussed. (C) 2010 Elsevier RV. All rights reserved.
C1 [Steinschneider, Mitchell] Albert Einstein Coll Med, Dept Neurosci, Rose F Kennedy Ctr, Bronx, NY 10461 USA.
[Steinschneider, Mitchell; Fishman, Yonatan I.] Albert Einstein Coll Med, Dept Neurol, Rose F Kennedy Ctr, Bronx, NY 10461 USA.
RP Steinschneider, M (reprint author), Albert Einstein Coll Med, Dept Neurosci, Rose F Kennedy Ctr, Room 322,1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM mitchell.steinschneider@einstein.yu.edu; yonatan.fishman@einstein.yu.edu
FU National Institute of Deafness and Other Communications Disorders
[DC-00657]
FX The authors thank Drs. Charles E. Schroeder and David H. Reser, and Ms.
Jeannie Hutagalung for their invaluable technical assistance. Supported
by National Institute of Deafness and Other Communications Disorders
Grant DC-00657.
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NR 89
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2011
VL 271
IS 1-2
SI SI
BP 103
EP 114
DI 10.1016/j.heares.2010.04.008
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 717VH
UT WOS:000287075000010
PM 20435116
ER
PT J
AU Recanzone, GH
Engle, JR
Juarez-Salinas, DL
AF Recanzone, Gregg H.
Engle, James R.
Juarez-Salinas, Dina L.
TI Spatial and temporal processing of single auditory cortical neurons and
populations of neurons in the macaque monkey
SO HEARING RESEARCH
LA English
DT Article
ID SOUND-LOCALIZATION BEHAVIOR; TIME-COMPRESSED SPEECH; RHESUS-MONKEY; GAP
DETECTION; INFERIOR COLLICULUS; CBA MOUSE; AZIMUTHAL SENSITIVITY; NEURAL
POPULATIONS; ELDERLY LISTENERS; WORD RECOGNITION
AB The auditory cortex is known to be a necessary neural structure for the perception of acoustic signals, particularly the spatial location and the temporal features of complex auditory stimuli. Previous studies have indicated that there is no topographic map of acoustic space in the auditory cortex and it has been proposed that spatial locations are represented by some sort of population code. Additionally, in spite of temporal processing deficits being one of the hallmark consequences of normal aging, the temporal coding of acoustic stimuli remains poorly understood. This report will address these two issues by discussing the results from several studies describing responses of single auditory cortical neurons in the non-human primate. First, we will review studies that have addressed potential spike-rate population codes of acoustic space in the caudal belt of auditory cortex. Second, we will present new data on the neuronal responses to gap stimuli in aged monkeys and compare them to published reports of gap detection thresholds. Together these studies indicate that the alert macaque monkey is an excellent model system to study both spatial and temporal processing in the auditory cortex at the single neuron level. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Recanzone, Gregg H.; Engle, James R.; Juarez-Salinas, Dina L.] Univ Calif Davis, Ctr Neurosci, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA.
RP Recanzone, GH (reprint author), Univ Calif Davis, Ctr Neurosci, Dept Neurobiol Physiol & Behav, 1 Shields Ave, Davis, CA 95616 USA.
EM ghrecanzone@ucdavis.edu
FU NIH [AG024372, DC-02371, DC-00442]
FX The authors would like to thank the California National Primate Research
Center, R. Oates-O'Brien, and G. Martin for excellent animal care.
Funding provided by NIH grants AG024372, DC-02371 and DC-00442.
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NR 61
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2011
VL 271
IS 1-2
SI SI
BP 115
EP 122
DI 10.1016/j.heares.2010.03.084
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 717VH
UT WOS:000287075000011
PM 20430079
ER
PT J
AU Eggermont, JJ
AF Eggermont, Jos J.
TI Context dependence of spectro-temporal receptive fields with
implications for neural coding
SO HEARING RESEARCH
LA English
DT Article
ID PRIMARY AUDITORY-CORTEX; COCHLEAR NUCLEUS NEURONS; STIMULUS-EVENT
RELATION; SINGLE-UNIT RESPONSES; REVERSE-CORRELATION; NATURAL STIMULI;
SOUND DENSITY; AWAKE FERRET; GUINEA-PIG; TEMPORAL CHARACTERISTICS
AB The spectro-temporal receptive field (STRF) is frequently used to characterize the Anew-frequency time filter properties of the auditory system up to the neuron recorded from. STRFs are extremely stimulus dependent, reflecting the strong non-linearities in the auditory system. Changes in the STRF with stimulus type (tonal, noise-like, vocalizations), sound level and spectro-temporal sound density are reviewed here. Effects on STRF shape of task and attention are also briefly reviewed. Models to account for these changes, potential improvements to STRF analysis, and implications for neural coding are discussed. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Eggermont, Jos J.] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
[Eggermont, Jos J.] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM eggermon@ucalgary.ca
FU Alberta Heritage Foundation for Medical Research; Natural Sciences and
Engineering Research Council; Canadian Institutes of Health Research;
Campbell McLaurin Chair for Hearing Deficiencies
FX This work was supported by the Alberta Heritage Foundation for Medical
Research, by the Natural Sciences and Engineering Research Council, by a
New Emerging Team Grant from the Canadian Institutes of Health Research,
and by the Campbell McLaurin Chair for Hearing Deficiencies. Martin
Pienkowski commented on a previous version.
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NR 69
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2011
VL 271
IS 1-2
SI SI
BP 123
EP 132
DI 10.1016/j.heares.2010.01.014
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 717VH
UT WOS:000287075000012
PM 20123121
ER
PT J
AU Hackett, TA
AF Hackett, Troy A.
TI Information flow in the auditory cortical network
SO HEARING RESEARCH
LA English
DT Article
ID MEDIAL GENICULATE-BODY; VENTROLATERAL PREFRONTAL CORTEX; CENTRAL
SEROTONERGIC NEUROTRANSMISSION; VESICULAR GLUTAMATE TRANSPORTERS;
SUPERIOR TEMPORAL SULCUS; OLD-WORLD MONKEYS; RHESUS-MONKEY;
FUNCTIONAL-ORGANIZATION; RESPONSE PROPERTIES; MACAQUE MONKEYS
AB Auditory processing in the cerebral cortex is comprised of an interconnected network of auditory and auditory-related areas distributed throughout the forebrain. The nexus of auditory activity is located in temporal cortex among several specialized areas, or fields, that receive dense inputs from the medial geniculate complex. These areas are collectively referred to as auditory cortex. Auditory activity is extended beyond auditory cortex via connections with auditory-related areas elsewhere in the cortex. Within this network, information flows between areas to and from countless targets, but in a manner that is characterized by orderly regional, areal and laminar patterns. These patterns reflect some of the structural constraints that passively govern the flow of information at all levels of the network. In addition, the exchange of information within these circuits is dynamically regulated by intrinsic neurochemical properties of projecting neurons and their targets. This article begins with an overview of the principal circuits and how each is related to information flow along major axes of the network. The discussion then turns to a description of neurochemical gradients along these axes, highlighting recent work on glutamate transporters in the thalamocortical projections to auditory cortex. The article concludes with a brief discussion of relevant neurophysiological findings as they relate to structural gradients in the network. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Hackett, Troy A.] Vanderbilt Univ, Dept Hearing & Speech Sci, Sch Med, Nashville, TN 37203 USA.
[Hackett, Troy A.] Vanderbilt Univ, Dept Psychol, Nashville, TN 37203 USA.
RP Hackett, TA (reprint author), Vanderbilt Univ, Dept Hearing & Speech Sci, Sch Med, 301 Wilson Hall,111 21st Ave S, Nashville, TN 37203 USA.
EM troy.a.hackett@vanderbilt.edu
FU NIH/NIDCD [RO1 DC04318, T32 MH075883]
FX The author gratefully acknowledges the support of NIH/NIDCD Grant RO1
DC04318 to T.A. Hackett and T32 MH075883 to Vanderbilt Kennedy Center
for support of the confocal microscope. We also thank Lisa de la Mothe,
Corrie Camalier and the reviewers for their helpful and insightful
comments.
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NR 141
TC 81
Z9 81
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2011
VL 271
IS 1-2
SI SI
BP 133
EP 146
DI 10.1016/j.heares.2010.01.011
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 717VH
UT WOS:000287075000013
PM 20116421
ER
PT J
AU Huetz, C
Gourevitch, B
Edeline, JM
AF Huetz, Chloe
Gourevitch, Boris
Edeline, Jean-Marc
TI Neural codes in the thalamocortical auditory system: From artificial
stimuli to communication sounds
SO HEARING RESEARCH
LA English
DT Article
ID SPATIOTEMPORAL FIRING PATTERNS; METRIC-SPACE ANALYSIS; CANARY HVC
NEURONS; BIRDS OWN SONG; SINGLE NEURONS; NATURAL SOUNDS; SPIKE TRAINS;
CONSPECIFIC VOCALIZATIONS; 1ST-SPIKE LATENCY; CORTICAL-NEURONS
AB Over the last 15 years, an increasing number of studies have described the responsiveness of thalamic and cortical neurons to communication sounds. Whereas initial studies have simply looked for neurons exhibiting higher firing rate to conspecific vocalizations over their modified, artificially synthesized versions, more recent studies determine the relative contribution of "rate coding" and "temporal coding" to the information transmitted by spike trains. In this article, we aim at reviewing the different strategies employed by thalamic and cortical neurons to encode information about acoustic stimuli, from artificial to natural sounds. Considering data obtained with simple stimuli, we first illustrate that different facets of temporal code, ranging from a strict correspondence between spike-timing and stimulus temporal features to more complex coding strategies, do already exist with artificial stimuli. We then review lines of evidence indicating that spike-timing provides an efficient code for discriminating communication sounds from thalamus, primary and non-primary auditory cortex up to frontal arms. As the neural code probably developed, and became specialized, over evolution to allow precise and reliable processing of sounds that are of survival value, we argue that spike-timing based coding strategies might set the foundations of our perceptive abilities. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Huetz, Chloe; Gourevitch, Boris; Edeline, Jean-Marc] Univ Paris 11, CNRS, UMR 8195, Ctr Neurosci Paris Sud, F-91405 Orsay, France.
RP Edeline, JM (reprint author), Univ Paris 11, CNRS, UMR 8195, Ctr Neurosci Paris Sud, Bat 446, F-91405 Orsay, France.
EM Jean-Marc.Edeline@u-psud.fr
FU ANR [Neuro2006]; Federation des Recherches sur le Cerveau (FRC)
FX Parts of the researches described in this review have been supported by
the ANR grant Neuro2006 "Hearing Loss" and by the Federation des
Recherches sur le Cerveau (FRC). We thank the reviewers for their
critical and helpful comments.
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NR 131
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2011
VL 271
IS 1-2
SI SI
BP 147
EP 158
DI 10.1016/j.heares.2010.01.010
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 717VH
UT WOS:000287075000014
PM 20116422
ER
PT J
AU Sim, JH
Lauxmann, M
Chatzimichalis, M
Roosli, C
Eiber, A
Huber, AM
AF Sim, Jae Hoon
Lauxmann, Michael
Chatzimichalis, Michail
Roeoesli, Christof
Eiber, Albrecht
Huber, Alexander M.
TI Errors in measurement of three-dimensional motions of the stapes using a
Laser Doppler Vibrometer system
SO HEARING RESEARCH
LA English
DT Article
ID HUMAN TEMPORAL BONES; HOLOGRAPHIC VIBRATION ANALYSIS; HUMAN MIDDLE-EAR;
TYMPANIC MEMBRANE; TRANSMISSION; VELOCITY; COCHLEA; GERBIL; SOUND
AB Previous studies have suggested complex modes of physiological stapes motions based upon various measurements. The goal of this study was to analyze the detailed errors in measurement of the complex stapes motions using Laser Doppler Vibrometer (LDV) systems, which are highly sensitive to the stimulation intensity and the exact angulations of the stapes. Stapes motions were measured with acoustic stimuli as well as mechanical stimuli using a custom-made three-axis piezoelectric actuator, and errors in the motion components were analyzed. The ratio of error in each motion component was reduced by increasing the magnitude of the stimuli, but the improvement was limited when the motion component was small relative to other components. This problem was solved with an improved reflectivity on the measurement surface. Errors in estimating the position of the stapes also caused errors on the coordinates of the measurement points and the laser beam direction relative to the stapes footplate, thus producing errors in the 3-D motion components. This effect was small when the position error of the stapes footplate did not exceed 5 degrees. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Sim, Jae Hoon; Chatzimichalis, Michail; Roeoesli, Christof; Huber, Alexander M.] Univ Zurich Hosp, Dept Otorhinolaryngol Head & Neck Surg, CH-8091 Zurich, Switzerland.
[Lauxmann, Michael; Eiber, Albrecht] Univ Stuttgart, Inst Engn & Computat Mech ITM, D-70569 Stuttgart, Germany.
RP Sim, JH (reprint author), Univ Zurich Hosp, Dept Otorhinolaryngol Head & Neck Surg, Frauenklin Str 24, CH-8091 Zurich, Switzerland.
EM JaeHoon.Sim@usz.ch; lauxmann@itm.uni-stuttgart.de
RI Huber, Alexander/A-2693-2009
OI Huber, Alexander/0000-0002-8888-8483
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NR 30
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 4
EP 14
DI 10.1016/j.heares.2010.08.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200003
PM 20801206
ER
PT J
AU Aarnisalo, AA
Green, KM
O'Malley, J
Makary, C
Adams, J
Merchant, SN
Evans, JE
AF Aarnisalo, Antti A.
Green, Karin M.
O'Malley, Jennifer
Makary, Chadi
Adams, Joe
Merchant, Saumil N.
Evans, James E.
TI A method for MSE differential proteomic analysis of archival
formalin-fixed celloidin-embedded human inner ear tissue
SO HEARING RESEARCH
LA English
DT Article
ID TEMPORAL BONES; CANCER-TISSUE; LC-MS/MS
AB Proteomic analysis of cadaveric formalin-fixed, celloidin-embedded (FFCE) temporal bone tissue has the potential to provide new insights into inner ear disorders. We have developed a liquid chromatography -mass spectrometry (LC-MS) method for tissue sections embedded with celloidin. Q-TOF (Quadrupole-time of flight mass spectrometry) MSE (mass spectrometry where E represents collision energy) and Identity(ETM) were used in conjunction with nano-UPLC (capillary ultrahigh pressure liquid chromatography) for robust identification and quantification of a large number of proteins.
Formalin-fixed paraffin-embedded (FFPE) mouse liver sections were used to evaluate formalin de-cross-linking by five different methods. Unfixed fresh mouse liver tissue was used as a control. Five different methods for preparation of FFPE tissue for MS analysis were compared, as well as four methods for celloidin removal with FFCE mouse liver tissue. The methods judged best were applied to FFCE 20 mu m sections of mouse inner ear samples, and FFCE 20 mu m human inner ear and human otic capsule bone sections.
Three of the five-tissue extraction methods worked equally in detecting peptides and proteins from FFPE mouse liver tissue. The modified Liquid Tissue kit protocol was chosen for further studies. Four different celloidin removal methods were compared and the acetone removal method was chosen for further analysis. These two methods were applied to the analysis of FFCE inner ear and otic capsule sections. Proteins from all major cellular components were detected in the FFCE archival human temporal bone sections. This newly developed technique enables the use of FFCE tissues for proteomic studies. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Aarnisalo, Antti A.; O'Malley, Jennifer; Makary, Chadi; Adams, Joe; Merchant, Saumil N.] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Boston, MA USA.
[Aarnisalo, Antti A.; Green, Karin M.; Evans, James E.] Univ Massachusetts, Sch Med, Worcester, MA USA.
RP Aarnisalo, AA (reprint author), Univ Helsinki, Helsinki Univ Cent Hosp, Dept Otorhinolaryngol, POB 220, Helsinki 00029, Finland.
EM antti.aarnisalo@hus.fi
FU NIH [U24 DC008559]; Sigrid Juselius Foundation; Academy of Finland
FX Supported in part by NIH grant U24 DC008559, Sigrid Juselius Foundation
(A.A.A) and Academy of Finland (A.A.A.).
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NR 19
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 15
EP 20
DI 10.1016/j.heares.2010.08.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200004
PM 20708670
ER
PT J
AU Polesskaya, O
Cunningham, LL
Francis, SP
Luebke, AE
Zhu, XX
Collins, D
Vasilyeva, ON
Sahler, J
Desmet, EA
Gelbard, HA
Maggirwar, SB
Walton, JR
Frisina, RD
Dewhurst, S
AF Polesskaya, Oksana
Cunningham, Lisa L.
Francis, Shimon P.
Luebke, Anne E.
Zhu, Xiaoxia
Collins, David
Vasilyeva, Olga N.
Sahler, Julie
Desmet, Emily A.
Gelbard, Harris A.
Maggirwar, Sanjay B.
Walton, Joseph R.
Frisina, Robert D., Jr.
Dewhurst, Stephen
TI Ablation of mixed lineage kinase 3 (MIk3) does not inhibit ototoxicity
induced by acoustic trauma or aminoglycoside exposure
SO HEARING RESEARCH
LA English
DT Article
ID HAIR CELL-DEATH; HEARING-LOSS; IN-VITRO; ACTIVATION; JNK; GENTAMICIN;
APOPTOSIS; PATHWAYS; FAMILY
AB Jun N-terminal kinase (INK) is activated in cochlear hair cells following acoustic trauma or exposure to aminoglycoside antibiotics. Blockade of JNK activation using mixed lineage kinase (MLK) inhibitors prevents hearing loss and hair cell death following these stresses. Since current pharmacologic inhibitors of MLKs block multiple members of this kinase family, we examined the contribution of the major neuronal family member (MLK3) to stress-induced ototoxicity, usingMlk3(-/-) mice. Immunohistochemical staining revealed that MLK3 is expressed in cochlear hair cells of C57/BL6 mice (but not in MIk3(-/-)animals). After exposure to acoustic trauma there was no significant difference in DPOAE and ABR values betweenMlk3(-/-) and wild-type mice at 48 h following exposure or 2 weeks later. Susceptibility of hair cells to aminoglycoside toxicity was tested by exposing explanted utricles to gentamicin. Gentamicin-induced hair cell death was equivalent in utricles from wild-type and MIk3(-/-) mice. Blockade of JNK activation with the pharmacologic inhibitor SP600125 attenuated cell death in utricles from both wildtype and MIk3-/- mice. These data show that MLK3 ablation does not protect against hair cell death following acoustic trauma or exposure to aminoglycoside antibiotics, suggesting that MLK3 is not the major upstream regulator of JNK-mediated hair cell death following these stresses. Rather, other MLK family members such as MLK1, which is also expressed in cochlea, may have a previously unappreciated role in noise- and aminoglycoside-induced ototoxicity. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Dewhurst, Stephen] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Sch Med & Dent, Rochester, NY 14642 USA.
[Gelbard, Harris A.] Univ Rochester, Sch Med & Dent, Ctr Neural Dev & Dis, Rochester, NY 14642 USA.
[Dewhurst, Stephen] Univ Rochester, James P Wilmot Canc Ctr, Sch Med & Dent, Rochester, NY 14642 USA.
[Frisina, Robert D., Jr.] Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
[Frisina, Robert D., Jr.] Rochester Inst Technol, Natl Tech Inst Deaf, Rochester, NY 14623 USA.
[Cunningham, Lisa L.; Francis, Shimon P.] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
RP Dewhurst, S (reprint author), Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Sch Med & Dent, 601 Elmwood Ave,Box 672, Rochester, NY 14642 USA.
EM Stephen_Dewhurst@urmc.rochester.edu
FU Schmitt Program on Integrative Brain Research; NIH [T32 NS051152, R01
DC003086, P01 MH064570, P01 AG09524]; NIH/NIDCD [R01 DC007613, R01
DC007613-S1]
FX We thank Dr. Roger Davis (U. Massachusetts Medical Center) for
generously providing the Mlk3-/- mice, and Dr. Fu-Shing Lee
(MUSC) for performing statistical analyses for this study. We also
acknowledge the following grants for providing financial support for
these experiments: a post-doctoral Fellowship from the Schmitt Program
on Integrative Brain Research (OP), NIH T32 NS051152 (OP), NIH/NIDCD R01
DC007613 (LC), NIH/NIDCD R01 DC007613-S1 (LC), NIH R01 DC003086 (AL),
NIH P01 MH064570 (OP, JS, ED, DC, HAG, SBM, SD), NIH P01 AG09524 (RF,
JW, OV, XZ).
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NR 18
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 21
EP 27
DI 10.1016/j.heares.2010.10.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200005
PM 20971179
ER
PT J
AU Berenstein, CK
Vanpoucke, FJ
Mulder, JJS
Mens, LHM
AF Berenstein, Carlo K.
Vanpoucke, Filiep J.
Mulder, Jef J. S.
Mens, Lucas H. M.
TI Electrical field imaging as a means to predict the loudness of monopolar
and tripolar stimuli in cochlear implant patients
SO HEARING RESEARCH
LA English
DT Article
ID ELECTRODE CONFIGURATION; MODEL; POSITIONER; PERCEPTION; LISTENERS; ARRAY
AB Tripolar and other electrode configurations that use simultaneous stimulation inside the cochlea have been tested to reduce channel interactions compared to the monopolar stimulation conventionally used in cochlear implant systems. However, these "focused" configurations require increased current levels to achieve sufficient loudness. In this study, we investigate whether highly accurate recordings of the intracochlear electrical field set up by monopolar and tripolar configurations correlate to their effect on loudness. We related the intra-scalar potential distribution to behavioral loudness, by introducing a free parameter (alpha) which parameterizes the degree to which the potential field peak set up inside the scala tympani is still present at the location of the targeted neural tissue. Loudness balancing was performed on four levels between behavioral threshold and the most comfortable loudness level in a group of 10 experienced Advanced Bionics cochlear implant users. The effect of the amount of focusing on loudness was well explained by alpha per subject location along the basilar membrane. We found that alpha was unaffected by presentation level. Moreover, the ratios between the monopolar and tripolar currents, balanced for equal loudness, were approximately the same for all presentation levels. This suggests a linear loudness growth with increasing current level and that the equal peak hypothesis may predict the loudness of threshold as well as at supra-threshold levels. These results suggest that advanced electrical field imaging, complemented with limited psychophysical testing, more specifically at only one presentation level, enables estimation of the loudness growth of complex electrode configurations. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Berenstein, Carlo K.; Mulder, Jef J. S.; Mens, Lucas H. M.] Radboud Univ Nijmegen, Med Ctr, KNO Audiol, NL-6500 HB Nijmegen, Netherlands.
[Vanpoucke, Filiep J.] Adv Bion European Res Ctr, Antwerp, Belgium.
RP Berenstein, CK (reprint author), Radboud Univ Nijmegen, Med Ctr, KNO Audiol 377, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM c.berenstein@kno.umcn.nl
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NR 30
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 28
EP 38
DI 10.1016/j.heares.2010.10.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200006
PM 20946945
ER
PT J
AU Sevy, ABG
Bortfeld, H
Huppert, TJ
Beauchamp, MS
Tonini, RE
Oghalai, JS
AF Sevy, Alexander B. G.
Bortfeld, Heather
Huppert, Theodore J.
Beauchamp, Michael S.
Tonini, Ross E.
Oghalai, John S.
TI Neuroimaging with near-infrared spectroscopy demonstrates speech-evoked
activity in the auditory cortex of deaf children following cochlear
implantation
SO HEARING RESEARCH
LA English
DT Article
ID SENSORINEURAL HEARING-LOSS; MULTISENSORY INTEGRATION; LANGUAGE
LATERALIZATION; CORTICAL REORGANIZATION; ELECTRICAL-STIMULATION;
FUNCTIONAL MRI; ACTIVATION; INFANTS; BRAIN; FMRI
AB Cochlear implants (CI) are commonly used to treat deafness in young children. While many factors influence the ability of a deaf child who is hearing through a CI to develop speech and language skills, an important factor is that the CI has to stimulate the auditory cortex. Obtaining behavioral measurements from young children with CIs can often be unreliable. While a variety of noninvasive techniques can be used for detecting cortical activity in response to auditory stimuli, many have critical limitations when applied to the pediatric CI population. We tested the ability of near-infrared spectroscopy (NIRS) to detect cortical responses to speech stimuli in pediatric CI users. Neuronal activity leads to changes in blood oxy-and deoxy-hemoglobin concentrations that can be detected by measuring the transmission of near-infrared light through the tissue. To verify the efficacy of NIRS, we first compared auditory cortex responses measured with NIRS and fMRI in normal-hearing adults. We then examined four different participant cohorts with NIRS alone. Speech-evoked cortical activity was observed in 100% of normal-hearing adults (11 of 11), 82% of normal-hearing children (9 of 11), 78% of deaf children who have used a CI > 4 months (28 of 36), and 78% of deaf children who completed NIRS testing on the day of CI initial activation (7 of 9). Therefore, NIRS can measure cortical responses in pediatric CI users, and has the potential to be a powerful adjunct to current CI assessment tools. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Oghalai, John S.] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
[Sevy, Alexander B. G.; Oghalai, John S.] Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA.
[Bortfeld, Heather] Univ Connecticut, Dept Psychol, Storrs, CT USA.
[Bortfeld, Heather] Haskins Labs Inc, New Haven, CT 06511 USA.
[Huppert, Theodore J.] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA.
[Beauchamp, Michael S.] Univ Texas Hlth Sci Ctr Houston, Dept Neurobiol & Anat, Houston, TX USA.
[Tonini, Ross E.; Oghalai, John S.] Texas Childrens Hosp, Hearing Ctr, Houston, TX 77030 USA.
[Oghalai, John S.] Rice Univ, Dept Bioengn, Houston, TX USA.
[Tonini, Ross E.] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
RP Oghalai, JS (reprint author), Stanford Univ, Dept Otolaryngol Head & Neck Surg, 801 Welch Rd, Stanford, CA 94305 USA.
EM joghalai@ohns.stanford.edu
FU Dana Foundation; NIH-NIDCD [R01 DC010075, R56 DC010164, T32 DC007367];
NSF [0642532]; NIH [R01 NS065395]
FX This research was funded by The Dana Foundation (to JSO and HB),
NIH-NIDCD R01 DC010075 and R56 DC010164 (to JSO), NSF Cognitive
Neuroscience Initiative Research Grant 0642532 and NIH R01 NS065395 (to
MSB). AS was supported by NIH-NIDCD T32 DC007367.
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NR 61
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 39
EP 47
DI 10.1016/j.heares.2010.09.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200007
PM 20888894
ER
PT J
AU Horner, KC
Troadec, JD
Blanchard, MP
Dallaporta, M
Pio, J
AF Horner, Kathleen C.
Troadec, Jean-Denis
Blanchard, Marie-Pierre
Dallaporta, Michel
Pio, Juliette
TI Receptors for leptin in the otic labyrinth and the cochlear-vestibular
nerve of guinea pig are modified in hormone-induced anorexia
SO HEARING RESEARCH
LA English
DT Article
ID SENSORINEURAL HEARING-LOSS; BONE-FORMATION; AUTOIMMUNE
ENCEPHALOMYELITIS; MENIERES-DISEASE; MESSENGER-RNA; RAT-BRAIN; IN-VIVO;
GENE-EXPRESSION; CHOROID-PLEXUS; KNOCKOUT MICE
AB Metabolic syndromic inner ear pathology is a recognized condition in clinical practice but the possible causes remain controversial. We have previously reported that chronically-implanted estrogen implants in guinea pig results in hyperprolactinemia and hearing loss together with otic bone dysmorphology. The animals also present with anorexia. The hormone leptin has major roles in the regulation of satiety as well as bone metabolism and so we hypothesized that leptin might contribute to pathology of the otic labyrinth. We employed immunohistochemistry to investigate leptin receptor (ObR) expression. In control animals, ObR immunolabeling was not detected in the bone of the otic capsule but immunolabeling was observed in the cochlear-vestibular nerve. The labeling was associated with the astrocytic glial dome area, which marks the transition between central and peripheral parts of the nerve. In estrogen-treated animals, positive-ObR immunolabeling was observed in osteoblasts in new bone of the otic capsule and the ObR labeling was reduced in the cochlear-vestibular nerve compared to controls. The data provide evidence that leptin may target the labyrinth - affecting the bone and the nerve - and so could contribute to ongoing protection of the inner ear. Leptin disturbance might contribute to metabolic syndromes involving the audiovestibular system. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Horner, Kathleen C.; Troadec, Jean-Denis; Dallaporta, Michel; Pio, Juliette] Univ Paul Cezanne, Dept Physiol Neurovegetat, Fac Sci & Tech, CRN2M, F-13397 Marseille 20, France.
[Blanchard, Marie-Pierre] IFR Jean Roche, Ctr Microscopie & Imagerie, Marseille 20, France.
RP Horner, KC (reprint author), Univ Paul Cezanne, Dept Physiol Neurovegetat, Fac Sci & Tech, CRN2M, Ave Escadrille Normandie Niemen, F-13397 Marseille 20, France.
EM kathleen.horner@univ-cezanne.fr
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NR 80
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 48
EP 55
DI 10.1016/j.heares.2010.09.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200008
PM 20875846
ER
PT J
AU McFadden, D
Hsieh, MD
Garcia-Sierra, A
Champlin, CA
AF McFadden, Dennis
Hsieh, Michelle D.
Garcia-Sierra, Adrian
Champlin, Craig A.
TI Differences by sex, ear, and sexual orientation in the time intervals
between successive peaks in auditory evoked potentials
SO HEARING RESEARCH
LA English
DT Article
ID BRAIN-STEM RESPONSE; OTOACOUSTIC EMISSIONS; TRANSMISSION TIME; HEAD
SIZE; LATENCY; AGE; REPLACEMENT; GENDER; AUTISM; WOMEN
AB Auditory evoked potential (AEP) data from two studies originally designed for other purposes were reanalyzed. The auditory brainstem response (ABR), middle-latency response (MLR), and long-latency response (LLR) were measured. The latencies to each of several peaks were measured for each subject for each ear of click presentation, and the time intervals between successive peaks were calculated. Of interest were differences in interpeak intervals between the sexes, between people of differing sexual orientations, and between the two ears of stimulation. Most of the differences obtained were small. The largest sex differences were for interval I -> V in the ABR and interval N1 -> N2 of the LLR (effect sizes > 0.6). The largest differences between heterosexuals and nonheterosexuals were for the latency to Wave I in both sexes, for the interval Na -> Nb in females, and for intervals V -> Na and Nb -> N1 in males (effect sizes > 0.3). The largest difference for ear stimulated was for interval N1 -> N2 in heterosexual females (effect size similar to 0.5). No substantial differences were found in the AEP intervals between women using, and not using, oral contraceptives. Left/right correlations for the interpeak intervals were mostly between about 0.4 and 0.6. Correlations between the ipsilateral intervals were small; i.e., interval length early in the AEP series was not highly predictive of interval length later in the series. Interpeak intervals appear generally less informative than raw latencies about differences by sex and by sexual orientation. (C) 2010 Elsevier B.V. All rights reserved.
C1 [McFadden, Dennis] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
[McFadden, Dennis; Champlin, Craig A.] Univ Texas Austin, Ctr Perceptual Syst, Austin, TX 78712 USA.
[Hsieh, Michelle D.; Champlin, Craig A.] Univ Texas Austin, Dept Commun Sci & Disorders, Austin, TX 78712 USA.
[Garcia-Sierra, Adrian] Univ Washington, Inst Learning & Brain Sci, Seattle, WA 98195 USA.
RP McFadden, D (reprint author), Univ Texas Austin, Dept Psychol, Seay Bldg,1 Univ Stn A8000, Austin, TX 78712 USA.
EM mcfadden@psy.utexas.edu; michellehsieh@mail.utexas.edu;
gasa@u.washington.edu; champlin@austin.utexas.edu
FU National Institute on Deafness and other Communication Disorders (NIDCD)
[RO1 DC000153]
FX This work was supported by a research grant awarded to DM by the
National Institute on Deafness and other Communication Disorders (NIDCD;
RO1 DC000153). The content is solely the responsibility of the authors
and does not necessarily represent the official views of the NIDCD or
the National Institutes of Health. E.G. Pasanen helped with the
resampling, M.M. Maloney helped with the figures, and Diana Simmons and
Lars Strother helped with early data analysis.
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NR 45
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 56
EP 64
DI 10.1016/j.heares.2010.09.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200009
PM 20875848
ER
PT J
AU Bloch, SL
Sorensen, MS
AF Bloch, Sune Land
Sorensen, Mads Solvsten
TI The viability and spatial distribution of osteocytes in the human
labyrinthine capsule: A quantitative study using vector-based stereology
SO HEARING RESEARCH
LA English
DT Article
ID REFERENT BONE TURNOVER; OTIC CAPSULE; HEARING-LOSS; OSTEOPROTEGERIN;
OTOSCLEROSIS; METABOLISM; REPAIR
AB Background: Bone remodeling is highly inhibited around the labyrinthine space, most likely by the action of the anti-resorptive cytokine osteoprotegerin (OPG). Inner ear OPG may enter the bony otic capsule through the lacuno-canalicular porosity (LCP). The aim of the study was to investigate the patency of this extracellular signaling pathway by exploring the viability, age dependency and spatial distribution of capsular osteocytes.
Methods: Sixty-five bulk-stained undecalcified human temporal bones were selected to span the ages from 30th gestational week to 95 years. Osteocytes within 1000 pm wide iso-concentric perilabyrinthine zones of bone were identified by 3-D vector calculations and the number of cells per unit of bone volume estimated within each zone by optical dissectors.
Results: From a high initial numerical density and a centripetal distribution of viable osteocytes, the density declined over time. This effect was higher towards the inner ear space and shifted viable osteocytes into to a centrifugal distribution with age. Contrary to this, non-viable osteocytes accumulated centripetally around the inner ear space and accounted for 50% of all lacunae at 80 years of age. Nonviable osteocytes were heterogeneously distributed forming islets of varying size surrounded by the intact and viable parts of the LCP.
Conclusion: The simultaneous presence of high numbers of non-viable osteocytes within a dense network of viable osteocytes is unique for the bony otic capsule. Viable osteocytes may sustain a life-long anti-resorptive signaling pathway for inner ear OPG. Clustering of non-viable osteocytes may locally impede the effect of OPG leaving the ghost regions unprotected against focal bone remodeling, as in human otosclerosis. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Bloch, Sune Land; Sorensen, Mads Solvsten] Univ Copenhagen, Rigshosp, Dept Otorhinolaryngol, DK-2100 Copenhagen, Denmark.
RP Bloch, SL (reprint author), Univ Copenhagen, Rigshosp, Dept Otorhinolaryngol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM sunebloch@hotmail.com
FU Oticon foundation
FX The authors thank the Oticon foundation for supporting this study.
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NR 23
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 65
EP 70
DI 10.1016/j.heares.2010.09.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200010
PM 20875847
ER
PT J
AU Brozoski, TJ
Caspary, DM
Bauer, CA
Richardson, BD
AF Brozoski, Thomas J.
Caspary, Donald M.
Bauer, Carol A.
Richardson, Benjamin D.
TI The effect of supplemental dietary Taurine on Tinnitus and auditory
discrimination in an animal model
SO HEARING RESEARCH
LA English
DT Article
ID DORSAL COCHLEAR NUCLEUS; BLOOD-BRAIN-BARRIER; EXTRASYNAPTIC GABA(A)
RECEPTORS; MODULATES CALCIUM INFLUX; RAT INFERIOR COLLICULUS;
NECROSIS-FACTOR-ALPHA; HIPPOCAMPAL-NEURONS; GLYCINE RECEPTORS; TONIC
INHIBITION; CHOROID-PLEXUS
AB Loss of central inhibition has been hypothesized to underpin tinnitus and impact auditory acuity. Taurine, a partial agonist at inhibitory glycine and gamma-amino butyric acid receptors, was added to the daily diet of rats to examine its effects on chronic tinnitus and normal auditory discrimination. Eight rats were unilaterally exposed once to a loud sound to induce tinnitus. The rats were trained and tested in an operant task shown to be sensitive to tinnitus. An equivalent unexposed control group was run in parallel. Months after exposure, 6 of the exposed rats showed significant evidence of chronic tinnitus. Two concentrations of taurine in drinking water were given over several weeks (attaining average daily doses of 67 mg/kg and 294 mg/kg). Water consumption was unaffected. Three main effects were obtained: (1) The high taurine dose significantly attenuated tinnitus, which returned to near pretreatment levels following washout. (2) Auditory discrimination was significantly improved in unexposed control rats at both doses. (3) As indicated by lever pressing, taurine at both doses had a significant group-equivalent stimulant effect. These results are consistent with the hypothesis that taurine attenuates tinnitus and improves auditory discrimination by increasing inhibitory tone and decreasing noise in the auditory pathway. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Brozoski, Thomas J.; Bauer, Carol A.] So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL 62794 USA.
[Caspary, Donald M.; Richardson, Benjamin D.] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA.
RP Brozoski, TJ (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, 801 N Rutledge St,Rm 3205,POB 19629, Springfield, IL 62794 USA.
EM tbrozoski@siumed.edu; dcaspary@siumed.edu; cbauer@siumed.edu;
brichardson@siumed.edu
RI Richardson, Ben/B-2922-2012
FU NIH [1RO1DC009669-01]
FX Supported by NIH grant 1RO1DC009669-01
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NR 75
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 71
EP 80
DI 10.1016/j.heares.2010.09.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200011
PM 20868734
ER
PT J
AU Li, TH
Fu, QJ
AF Li, Tianhao
Fu, Qian-Jie
TI Effects of spectral shifting on speech perception in noise
SO HEARING RESEARCH
LA English
DT Article
ID COCHLEAR IMPLANT USERS; FUNDAMENTAL-FREQUENCY; CONCURRENT-VOWEL;
ELECTRIC HEARING; CONSONANT RECOGNITION; TEMPORAL CUES; ENVELOPE CUES;
INTELLIGIBILITY; ADAPTATION; RESOLUTION
AB The present study used eight normal-hearing (NH) subjects, listening to acoustic cochlear implant (CI) simulations, to examine the effects of spectral shifting on speech recognition in noise. Speech recognition was measured using spectrally matched and shifted speech (vowels, consonants, and IEEE sentences), generated by 8-channel, sine-wave vocoder. Measurements were made in quiet and in noise (speech-shaped static noise and speech-babble at 5 dB signal-to-noise ratio). One spectral match condition and four spectral shift conditions were investigated: 2 mm, 3 mm, and 4 mm linear shift, and 3 mm shift with compression, in terms of cochlear distance. Results showed that speech recognition scores dropped because of noise and spectral shifting, and that the interactive effects of spectral shifting and background conditions depended on the degree/type of spectral shift, background conditions, and the speech test materials. There was no significant interaction between spectral shifting and two noise conditions for all speech test materials. However, significant interactions between linear spectral shifts and all background conditions were found in sentence recognition; significant interactions between spectral shift types and all background conditions were found in vowel recognition. Overall, the results suggest that tonotopic mismatch may affect performance of CI users in complex listening environments. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Li, Tianhao; Fu, Qian-Jie] House Ear Res Inst, Div Commun & Auditory Neurosci, Los Angeles, CA 90057 USA.
RP Li, TH (reprint author), House Ear Res Inst, Div Commun & Auditory Neurosci, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM tianhaol@gmail.com
FU NIH/NIDCD [R01DC004972]
FX The authors would like to thank all subjects for their attention and
time. We thank three anonymous reviewers for their valuable comments on
the earlier version of the paper. NIH/NIDCD R01DC004972 supported the
present project.
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NR 50
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 81
EP 88
DI 10.1016/j.heares.2010.09.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200012
PM 20868733
ER
PT J
AU Srinivasan, AG
Landsberger, DM
Shannon, RV
AF Srinivasan, Arthi G.
Landsberger, David M.
Shannon, Robert V.
TI Current focusing sharpens local peaks of excitation in cochlear implant
stimulation
SO HEARING RESEARCH
LA English
DT Article
ID SPEECH-RECOGNITION; ELECTRODE CONFIGURATIONS; SPECTRAL RESOLUTION;
CHANNEL INTERACTION; TEMPORAL CUES; TUNING CURVES; RECIPIENTS; USERS;
PATTERNS; PERCEPTION
AB Cochlear implant (CI) users' spectral resolution is limited by the number of implanted electrodes, interactions between the electrodes, and the underlying neural population. Current steering has been proposed to increase the number of spectral channels beyond the number of physical electrodes, however, electric field interactions may limit CI users' access to current-steered virtual channels (VCs). Current focusing (e.g tripolar stimulation) has been proposed to reduce current spread and thereby reduce interactions. In this study, current steering and current focusing were combined in a four-electrode stimulation pattern, i.e quadrupolar virtual channels (QPVCs). The spread of excitation was measured and compared between QPVC and Monopolar VC (MPVC) stimuli using a forward masking task. Results showed a sharper peak in the excitation pattern and reduced spread of masking for QPVC stimuli. Results from the forward masking study were compared with a previous study measuring VC discrimination ability and showed a weak relationship between spread of excitation and VC discriminability. The results suggest that CI signal processing strategies that utilize both current steering and current focusing might increase CI users' functional spectral resolution by transmitting more channels and reducing channel interactions. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Srinivasan, Arthi G.; Landsberger, David M.; Shannon, Robert V.] House Ear Res Inst, Dept Commun & Auditory Neurosci, Los Angeles, CA 90057 USA.
[Srinivasan, Arthi G.; Shannon, Robert V.] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA.
RP Srinivasan, AG (reprint author), House Ear Res Inst, Dept Commun & Auditory Neurosci, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM asrinivasan@hei.org
FU NIDCD [R01-DC-001526, R03-DC-010064, F31 DC011205-01]
FX This work was supported by NIDCD Grants and Fellowship Numbers:
R01-DC-001526, R03-DC-010064, and F31 DC011205-01. We gratefully
acknowledge the Cl subjects who participated in this study. We also
thank John J. Galvin III for editorial help.
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NR 37
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 89
EP 100
DI 10.1016/j.heares.2010.09.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200013
PM 20850513
ER
PT J
AU Wang, Y
Ren, CY
Manis, PB
AF Wang, Yong
Ren, Chongyu
Manis, Paul B.
TI Endbulb synaptic depression within the range of presynaptic spontaneous
firing and its impact on the firing reliability of cochlear nucleus
bushy neurons
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY BRAIN-STEM; PAIRED-PULSE DEPRESSION; NERVE FIBERS; RECEPTOR
DESENSITIZATION; DEVELOPMENTAL-CHANGES; RELEASE PROBABILITY; CALCIUM
CURRENT; CA2+ CHANNELS; HELD SYNAPSE; HEARING-LOSS
AB The majority of auditory nerve fibers exhibit prominent spontaneous activity in the absence of sound. More than half of all auditory nerve fibers in CBA mice have spontaneous firing rates higher than 20 spikes/s, with some fibers exceeding 100 spikes/s. We tested whether and to what extent endbulb synapses are depressed by activity between 10 and 100 Hz, within the spontaneous firing rates of auditory nerve fibers. In contrast to rate-dependent depression seen at rates >100 Hz, we found that the extent of depression was essentially rate-independent (similar to 35%) between 10 and 100 Hz. Neither cyclothiazide nor gamma-D-glutamylglycine altered the rate-independent depression, arguing against receptor desensitization and/or vesicle depletion as major contributors for the depression. When endbulb synaptic transmission was more than half-blocked with the P/Q Ca(2+) channel blocker omega-agatoxin IVA, depression during 25 and 100 Hz trains was significantly attenuated, indicating P/Q Ca(2+) channel inactivation may contribute to low frequency synaptic depression. Following conditioning with a 100 Hz Poisson train, the EPSC paired-pulse ratio was increased, suggesting a reduced release probability. This in turn should reduce subsequent depletion-based synaptic depression at higher activation rates. To probe whether this conditioning of the synapse improves the reliability of postsynaptic responses, we tested the firing reliability of bushy neurons to 200 Hz stimulation after conditioning the endbulb with a 25 Hz or 100 Hz stimulus train. Although immediately following the conditioning train, bushy cells responded to minimal suprathreshold stimulation less reliably, the firing reliability eventually settled to the same level (<50%) regardless of the presence or absence of the preconditioning. However, when multiple presynaptic fibers were activated simultaneously, the postsynaptic response reliability did not drop significantly below 90%. These results suggest that single endbulb terminals do not reliably trigger action potentials in bushy cells under "normal" operating conditions. We conclude that the endbulb synapses are chronically depressed even by low rates of spontaneous activity, and are more resistant to further depression when challenged with a higher rate of activity. However, there seems to be no beneficial effect as assessed by the firing reliability of postsynaptic neurons for transmitting information about higher rates of activity. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wang, Yong; Ren, Chongyu] Univ Utah, Div Otolaryngol, Sch Med 3C120, Salt Lake City, UT 84132 USA.
[Wang, Yong; Ren, Chongyu] Univ Utah, Program Neurosci, Sch Med 3C120, Salt Lake City, UT 84132 USA.
[Manis, Paul B.] Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27516 USA.
[Manis, Paul B.] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27516 USA.
RP Wang, Y (reprint author), Univ Utah, Div Otolaryngol, Sch Med 3C120, 30 North,1900 East, Salt Lake City, UT 84132 USA.
EM yong.wang@hsc.utah.edu
FU NIDCD [R03DC008190, R01DC04551]
FX Supported by NIDCD grants R03DC008190 to YW and R01DC04551 to PBM.
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NR 47
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 101
EP 109
DI 10.1016/j.heares.2010.09.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200014
PM 20850512
ER
PT J
AU Ishihara, K
Okuyama, S
Kumano, S
Iida, K
Hamana, H
Murakoshi, M
Kobayashi, T
Usami, S
Ikeda, K
Haga, Y
Tsumoto, K
Nakamura, H
Hirasawa, N
Wada, H
AF Ishihara, Kenji
Okuyama, Shuhei
Kumano, Shun
Iida, Koji
Hamana, Hiroshi
Murakoshi, Michio
Kobayashi, Toshimitsu
Usami, Shinichi
Ikeda, Katsuhisa
Haga, Yoichi
Tsumoto, Kohei
Nakamura, Hiroyuki
Hirasawa, Noriyasu
Wada, Hiroshi
TI Salicylate restores transport function and anion exchanger activity of
missense pendrin mutations
SO HEARING RESEARCH
LA English
DT Article
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NONSYNDROMIC HEARING-LOSS; OUTER
HAIR-CELLS; HISTONE DEACETYLASES; VESTIBULAR AQUEDUCT; IODIDE TRANSPORT;
RECEPTOR MUTANTS; MOTOR PROTEIN; SYNDROME GENE; HUMAN-DISEASE
AB The SLC26A4 gene encodes the transmembrane protein pendrin, which is involved in the homeostasis of the ion concentration of the endolymph of the inner ear, most likely by acting as a chloride/bicarbonate transporter. Mutations in the SLC26A4 gene cause sensorineuronal hearing loss. However, the mechanisms responsible for such loss have remained unknown. Therefore, in this study, we focused on the function of ten missense pendrin mutations (p.P123S (Pendred syndrome), p.M147V (NSEVA), p.K369E (NSEVA), p.A372V (Pendred syndrome/NSEVA), p.N392Y (Pendred syndrome), p.C565Y (NSEVA), p.S657N (NSEVA), p.S666F (NSEVA), p.T721M (NSEVA) and p.H723R (Pendred syndrome/NSEVA)) reported in Japanese patients, and analyzed their cellular localization and anion exchanger activity using HEK293 cells transfected with each mutant gene. Immunofluorescent staining of the cellular localization of the pendrin mutants revealed that p.K369E and p.C565Y, as well as wild-type pendrin, were transported to the plasma membrane, while 8 other mutants were retained in the cytoplasm. Furthermore, we analyzed whether salicylate, as a pharmacological chaperone, restores normal plasma membrane localization of 8 pendrin mutants retained in the cytoplasm to the plasma membrane. Incubation with 10 mM of salicylate of the cells transfected with the mutants induced the transport of 4 pendrin mutants (p.P123S, p.M147V, p.S657Y and p.H723R) from the cytoplasm to the plasma membrane and restored the anion exchanger activity. These findings suggest that salicylate might contribute to development of a new method of medical treatment for sensorineuronal hearing loss caused by the mutation of the deafness-related proteins, including pendrin. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Ishihara, Kenji; Okuyama, Shuhei; Kumano, Shun; Iida, Koji; Hamana, Hiroshi; Murakoshi, Michio; Wada, Hiroshi] Tohoku Univ, Grad Sch Engn, Dept Bioengn & Robot, Aoba Ku, Sendai, Miyagi 9808579, Japan.
[Ishihara, Kenji] Ibaraki Univ, Fac Educ, Lab Med Sci, Course Sch Nurse Teacher, Ibaraki 3108512, Japan.
[Kobayashi, Toshimitsu] Tohoku Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi 9808575, Japan.
[Usami, Shinichi] Shinshu Univ, Sch Med, Dept Otorhinolaryngol, Matsumoto, Nagano 3908621, Japan.
[Ikeda, Katsuhisa] Juntendo Univ, Sch Med, Dept Otorhinolaryngol, Chiba 1138421, Japan.
[Haga, Yoichi] Tohoku Univ, Grad Sch Biomed Engn, Dept Biomed Engn, Sendai, Miyagi 9808579, Japan.
[Tsumoto, Kohei] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Tokyo 2778562, Japan.
[Nakamura, Hiroyuki] Gakusyuin Univ, Dept Chem, Fac Sci, Tokyo 1718588, Japan.
[Hirasawa, Noriyasu] Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Pharmacotherapy Life Style Related Dis, Sendai, Miyagi 9808578, Japan.
RP Wada, H (reprint author), Tohoku Univ, Grad Sch Engn, Dept Bioengn & Robot, Aoba Ku, 6-6-01 Aoba, Sendai, Miyagi 9808579, Japan.
EM wada@cc.mech.tohoku.ac.jp
RI Nakamura, Hiroyuki/E-8627-2014
OI Nakamura, Hiroyuki/0000-0002-4511-2984
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
[15086202, 20659263]; Japan Society for the Promotion of Science
[20390439]; Human Frontier Science Program; Ministry of Health, Labor
and Welfare of Japan; Iketani Science and Technology Foundation; Daiwa
Securities Health Foundation; Tohoku University, Global Nano-Biomedical
Engineering Education and Research Network Centre
FX This work was supported by Grant-in-Aid for Scientific Research on
Priority Areas 15086202 from the Ministry of Education, Culture, Sports,
Science and Technology of Japan, by Grant-in-Aid for Scientific Research
(B) 20390439 from the Japan Society for the Promotion of Science, by
Grant-in-Aid for Exploratory Research 20659263 from the Ministry of
Education, Culture, Sports, Science and Technology of Japan, by a grant
from the Human Frontier Science Program, by a Health and Labor Science
Research Grant from the Ministry of Health, Labor and Welfare of Japan,
by a grant from the Iketani Science and Technology Foundation, by a
grant from the Daiwa Securities Health Foundation and by Tohoku
University Global COE Program "Global Nano-Biomedical Engineering
Education and Research Network Centre" to H.W.
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NR 35
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 110
EP 118
DI 10.1016/j.heares.2010.08.015
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200015
PM 20826203
ER
PT J
AU Sterenborg, JC
Pilati, N
Sheridan, CJ
Uchitel, OD
Forsythe, ID
Barnes-Davies, M
AF Sterenborg, Jessica C.
Pilati, Nadia
Sheridan, Craig J.
Uchitel, Osvaldo D.
Forsythe, Ian D.
Barnes-Davies, Margaret
TI Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory
and inhibitory synaptic inputs with slower kinetics than LSO principal
neurons
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY BRAIN-STEM; SUPERIOR OLIVARY NUCLEUS; INFERIOR COLLICULUS; AMPA
RECEPTORS; GLUTAMATE RECEPTORS; RAT; TRANSMISSION; SUBUNIT; MEDIATE;
SLICE
AB We examined membrane properties and synaptic responses of neurons in the mouse lateral superior olivary nucleus (LSO). Two clear populations were identified consistent with: principal neurons which are involved in detecting interaural intensity differences (IIDs) and efferent neurons of the lateral olivocochlear (LOC) system which project to the cochlea. Principal neurons fired a short latency action potential (AP) often followed by an AP train during maintained depolarization. They possessed sustained outward K+ currents, with little or no transient K+ current (I-A) and a prominent hyperpolarization-activated non-specific cation conductance, I-H. On depolarization, LOC neurons exhibited a characteristic delay to the first AP. These neurons possessed a prominent transient outward current IA, but had no IH. Both LOC and principal neurons received glutamatergic and glycinergic synaptic inputs. LOC synaptic responses decayed more slowly than those of principal neurons; the mean decay time constant of AMPA receptor-mediated EPSCs was around 1 ms in principal neurons and 4 ms in LOC neurons. Decay time constants for glycinergic IPSCs were around 5 ms in principal neurons and 10 ms in LOC neurons. We conclude that principal cells receive fast synaptic responses appropriate for integration of IID inputs, while the LOC cells possess excitatory and inhibitory receptors with much slower kinetics. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Barnes-Davies, Margaret] Univ Leicester, Dept Med & Social Care Educ, Leicester LE1 9HN, Leics, England.
[Sterenborg, Jessica C.; Sheridan, Craig J.; Forsythe, Ian D.; Barnes-Davies, Margaret] Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England.
[Pilati, Nadia; Forsythe, Ian D.] Univ Leicester, MRC Toxicol Unit, Leicester LE1 9HN, Leics, England.
[Uchitel, Osvaldo D.] Univ Buenos Aires, Fac Ciencias Exactas & Nat, CONICET, Inst Fisiol & Biol Mol & Neurociencias, Buenos Aires, DF, Argentina.
RP Barnes-Davies, M (reprint author), Univ Leicester, Dept Med & Social Care Educ, POB 138, Leicester LE1 9HN, Leics, England.
EM mb27@le.ac.uk
FU Wellcome Trust; The Health Foundation; Physiological Society
FX This work was supported by the Wellcome Trust, the MRC and Intercalated
BSc Studentships to JCS from The Health Foundation and to CJS from the
Physiological Society.
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NR 38
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 119
EP 126
DI 10.1016/j.heares.2010.08.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200016
PM 20813177
ER
PT J
AU Baskent, D
Chatterjeec, M
AF Baskent, Deniz
Chatterjeec, Monita
TI Recognition of temporally interrupted and spectrally degraded sentences
with additional unprocessed low-frequency speech
SO HEARING RESEARCH
LA English
DT Article
ID SENSORINEURAL HEARING-LOSS; COCHLEAR IMPLANT USERS; ACOUSTIC HEARING;
PERIODIC INTERRUPTIONS; PHONEMIC RESTORATION; INTELLIGIBILITY;
LISTENERS; NOISE; CUES; INFORMATION
AB Recognition of periodically interrupted sentences (with an interruption rate of 1.5 Hz, 50% duty cycle) was investigated under conditions of spectral degradation, implemented with a noiseband vocoder, with and without additional unprocessed low-pass filtered speech (cutoff frequency 500 Hz). Intelligibility of interrupted speech decreased with increasing spectral degradation. For all spectral degradation conditions, however, adding the unprocessed low-pass filtered speech enhanced the intelligibility. The improvement at 4 and 8 channels was higher than the improvement at 16 and 32 channels: 19% and 8%, on average, respectively. The Articulation Index predicted an improvement of 0.09, in a scale from 0 to 1. Thus, the improvement at poorest spectral degradation conditions was larger than what would be expected from additional speech information. Therefore, the results implied that the fine temporal cues from the unprocessed low-frequency speech, such as the additional voice pitch cues, helped perceptual integration of temporally interrupted and spectrally degraded speech, especially when the spectral degradations were severe. Considering the vocoder processing as a cochlear implant simulation, where implant users' performance is closest to 4 and 8-channel vocoder performance, the results support additional benefit of low-frequency acoustic input in combined electric-acoustic stimulation for perception of temporally degraded speech. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Baskent, Deniz] Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, NL-9700 RB Groningen, Netherlands.
[Baskent, Deniz] Univ Groningen, Sch Behav & Cognit Neurosci, NL-9700 AB Groningen, Netherlands.
[Chatterjeec, Monita] Univ Maryland, Cochlear Implants & Psychophys Lab, Dept Hearing & Speech Sci, College Pk, MD 20742 USA.
RP Baskent, D (reprint author), Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM d.baskent@med.umcg.nl; mchatterjee@hesp.umd.edu
RI Imhof, Margarete/F-8471-2011
FU Heinsus Houbolt Foundation; University of Groningen; NIH/NIDCD
[R01-DC004786]
FX This work was supported by Heinsus Houbolt Foundation and by a Rosalind
Franklin Fellowship from the University of Groningen the second author
was supported by the NIH/NIDCD Grant no. R01-DC004786. The authors would
like to thank Michal Stone for earlier comments on the design of the
vocoder processor, Frits Leemhuis for help with experimental set-up,
Nico Leenstra with evaluation of the participant responses, Joost Festen
and Wouter Dreschler for help with the speech stimuli, William S. Woods
and Hari Natarajan for help with the Articulation Index software, and
the participants for all their efforts.
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NR 38
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 127
EP 133
DI 10.1016/j.heares.2010.08.011
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200017
PM 20817081
ER
PT J
AU Bierer, JA
Bierer, SM
Middlebrooks, JC
AF Bierer, Julie Arenberg
Bierer, Steven M.
Middlebrooks, John C.
TI Partial tripolar cochlear implant stimulation: Spread of excitation and
forward masking in the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY CORTICAL IMAGES; PSYCHOPHYSICAL TUNING CURVES; ELECTRODE-NEURON
INTERFACE; CONFIGURATION; CHANNEL; THRESHOLD; INTRACOCHLEAR; ACTIVATION;
PATTERNS; DEAFNESS
AB This study examines patterns of neural activity in response to single biphasic electrical pulses, presented alone or following a forward masking pulse train, delivered by a cochlear implant. Recordings were made along the tonotopic axis of the central nucleus of the inferior colliculus (ICC) in ketamine/xylazine anesthetized guinea pigs. The partial tripolar electrode configuration was used, which provided a systematic way to vary the tonotopic extent of ICC activation between monopolar (broad) and tripolar (narrow) extremes while maintaining the same peak of activation. The forward masking paradigm consisted of a 200 ms masker pulse train (1017 pulses per second) followed 10 ms later by a single-pulse probe stimulus; the current fraction of the probe was set to 0 (monopolar), 1 (tripolar), or 0.5 (hybrid), and the fraction of the masker was fixed at 0.5. Forward masking tuning profiles were derived from the amount of masking current required to just suppress the activity produced by a fixed-level probe. These profiles were sharper for more focused probe configurations, approximating the pattern of neural activity elicited by single (non-masked) pulses. The result helps to bridge the gap between previous findings in animals and recent psychophysical data. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Bierer, Julie Arenberg] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA.
[Bierer, Julie Arenberg] Univ Washington, Bloedel Hearing Res Ctr, Seattle, WA 98105 USA.
[Bierer, Steven M.] Univ Washington, Dept Otolaryngol, Seattle, WA 98105 USA.
[Middlebrooks, John C.] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Irvine, CA 92717 USA.
[Middlebrooks, John C.] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92717 USA.
[Middlebrooks, John C.] Univ Calif Irvine, Dept Cognit Sci, Irvine, CA 92717 USA.
RP Bierer, JA (reprint author), Univ Washington, Dept Speech & Hearing Sci, 1417 NE 42nd St,Box 354875, Seattle, WA 98105 USA.
EM jbierer@u.washington.edu
FU University of Washington; Bloedel Mini grant; Bloedel Traveling Scholar;
National Institutes of Health [NIDCD- R03 DC8883, RO1-DC04312]; [P30
DC04661]
FX The authors would like to thank C. El linger for his engineering
expertise and E. Rubel for sharing resources. This work was supported by
the University of Washington, Bloedel Mini grant (JAB) and Bloedel
Traveling Scholar (JCM) and P30 DC04661, and National Institutes of
Health (NIDCD- R03 DC8883 to JAB and RO1-DC04312 to JCM).
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NR 41
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 134
EP 142
DI 10.1016/j.heares.2010.08.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200018
PM 20727397
ER
PT J
AU Dai, HP
AF Dai, Huanping
TI Harmonic pitch: Dependence on resolved partials, spectral edges, and
combination tones
SO HEARING RESEARCH
LA English
DT Article
ID MULTIPLE-OBSERVATION TASKS; COMPLEX TONES; UNRESOLVED HARMONICS;
CORRELATION-COEFFICIENTS; FUNDAMENTAL-FREQUENCY; AUDITORY PERIPHERY;
PHASE SENSITIVITY; DOMINANCE REGION; COMPUTER-MODEL; VIRTUAL PITCH
AB Perceptual weights were estimated in a pitch-comparison experiment to assess the relative influences of individual partial tones on listeners' pitch judgments. The stimuli were harmonic sounds (F0 = 200 Hz) with partials up to the 12th. Low-numbered partials were removed step-by-step, so that the remaining higher-numbered partials would have a better chance of showing any effect. The individual frequencies of the partials were perturbed randomly on each stimulus presentation, and weights were estimated as the correlation coefficients between the frequency perturbations and the listeners' responses. When the harmonic sounds contained all twelve partials, the listeners depended mostly on the low-numbered, resolved partials within the well-established dominance region. As the low-numbered partials were taken out of the dominance region, the listeners mostly listened to the lowest and highest partials at the spectral edges. For one listener, such an edge-listening strategy took the form of relying on nonlinear combination tones. Overall, there was no indication of any influence on pitch from unresolved partials, thus no evidence of contribution to pitch from temporal cues carried by this group of partials. The estimated patterns of weights were well described by the predictions of Goldstein's optimal-processor model. The predicted weights were inversely proportional to the amount of error for estimating the individual frequencies of the partials. The agreement between the predicted and measured weights suggests that, for harmonic sounds, partials whose frequencies are perceived with the best precision will likely have the greatest influence on perceived pitch. (C) 2010 Elsevier B.V. All rights reserved.
C1 Univ Arizona, Dept Speech Language & Hearing Sci, Tucson, AZ 85721 USA.
RP Dai, HP (reprint author), Univ Arizona, Dept Speech Language & Hearing Sci, 1131 E 2nd St, Tucson, AZ 85721 USA.
EM hdai@email.arizona.edu
FU NIH/NIDCD [R29-DC01827]
FX I thank William Hartmann, Douglas Keefe, Christophe Micheyl, Andrew
Oxenham, and Fan-Gang Zeng for helpful discussions, and Tom Christenson,
William Hartmann, Christophe Micheyl, Brian Moore, and an anonymous
reviewer for their comments and suggestions on previous versions of this
paper. This research was supported by NIH/NIDCD Grant R29-DC01827.
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NR 51
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 143
EP 150
DI 10.1016/j.heares.2010.08.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200019
PM 20709166
ER
PT J
AU Anderson, S
Skoe, E
Chandrasekaran, B
Zecker, S
Kraus, N
AF Anderson, Samira
Skoe, Erika
Chandrasekaran, Bharath
Zecker, Steven
Kraus, Nina
TI Brainstem correlates of speech-in-noise perception in children
SO HEARING RESEARCH
LA English
DT Article
ID FREQUENCY-FOLLOWING RESPONSES; LANGUAGE-IMPAIRED CHILDREN; MUSICAL
EXPERIENCE; DEVELOPMENTAL DYSLEXIA; LEARNING-PROBLEMS; SCHOOL-CHILDREN;
PITCH PATTERNS; HEARING-LOSS; DEFICITS; ATTENTION
AB Children often have difficulty understanding speech in challenging listening environments. In the absence of peripheral hearing loss, these speech perception difficulties may arise from dysfunction at more central levels in the auditory system, including subcortical structures. We examined brainstem encoding of pitch in a speech syllable in 38 school-age children. In children with poor speech-in-noise perception, we find impaired encoding of the fundamental frequency and the second harmonic, two important cues for pitch perception. Pitch, an essential factor in speaker identification, aids the listener in tracking a specific voice from a background of voices. These results suggest that the robustness of subcortical neural encoding of pitch features in time-varying signals is a key factor in determining success with perceiving speech in noise. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Anderson, Samira; Skoe, Erika; Zecker, Steven; Kraus, Nina] Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA.
[Chandrasekaran, Bharath] Univ Texas Austin, Austin, TX 78712 USA.
[Kraus, Nina] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA.
[Kraus, Nina] Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol, Chicago, IL 60611 USA.
RP Anderson, S (reprint author), Northwestern Univ, Dept Commun Sci & Disorders, 2240 Campus Dr, Evanston, IL 60208 USA.
EM sba@u.northwestern.edu
FU National Institutes of Health [RO1 DC01510]; Hugh Knowles Center of
Northwestern University
FX This work was funded by the National Institutes of Health (RO1 DC01510)
and the Hugh Knowles Center of Northwestern University. We would like to
thank Trent Nicol, Judy Song, Jane Hornickel, Alexandra Parbery-Clark,
Jennifer Krizman, and Kyung Myun Lee for their helpful comments and
suggestions regarding an earlier version of the manuscript. We would
especially like to thank the children and their families who
participated in the study.
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NR 86
TC 21
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 151
EP 157
DI 10.1016/j.heares.2010.08.001
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200020
PM 20708671
ER
PT J
AU de La Rochefoucauld, O
Kachroo, P
Olson, ES
AF de La Rochefoucauld, Ombeline
Kachroo, Puja
Olson, Elizabeth S.
TI Ossicular motion related to middle ear transmission delay in gerbil
SO HEARING RESEARCH
LA English
DT Article
ID TYMPANIC-MEMBRANE PERFORATIONS; SOUND-TRANSMISSION; MALLEUS VIBRATION;
MONGOLIAN GERBIL; INPUT IMPEDANCE; NETWORK MODEL; CAT EARDRUM;
INNER-EAR; 100 HZ; KHZ
AB The middle ear transmits sound efficiently from the air in the ear canal (EC) to the fluid filled cochlea. In gerbil, middle ear transmission produces a constant pressure gain between the EC and the cochlea of similar to 25 dB from 2 to 40 kHz, and a delay-like phase corresponding to a similar to 25-30 mu s delay. The mechanisms by which the air-born signal is collected and delivered to the cochlea are not thoroughly understood, and the source of the delay is controversial. We investigated these issues by observing ossicular motion along a single line of sight, roughly parallel to the EC and perpendicular to the stapes footplate. Measurements were made at the umbo, the long process of the manubrium, across the malleus-incus joint, at the long process of the incus, and the stapes head. While the overall delay between EC pressure and stapes velocity was fairly constant with frequency, subcomponents of the delay were frequency dependent. Up to similar to 17 kHz, most of the overall delay was between the EC and umbo with a much smaller contribution along the ossicles, whereas in the range from similar to 17 to 30 kHz, more of the overall delay was along the ossicles. (C) 2010 Elsevier B.V. All rights reserved.
C1 [de La Rochefoucauld, Ombeline; Kachroo, Puja; Olson, Elizabeth S.] Columbia Univ, New York, NY 10032 USA.
RP de La Rochefoucauld, O (reprint author), Columbia Univ, 630 W 168th St, New York, NY 10032 USA.
EM odelarochefoucauld@gmail.com
FU NIH/NIDCD [DC003130]; Emil Capita Foundation
FX We thank John Rosowski and an anonymous reviewer for their helpful
comments on the manuscript. We are grateful to Mike Ravicz, John
Rosowski and Nigel Cooper for sharing the data of Fig. 9. We also thank
Wei Dong, Shyam Khanna, Wim Decraemer, John Rosowski, Glenis Long and
Mike Ravicz for many discussions on delays. This work was supported by
the NIH/NIDCD (DC003130) and the Emil Capita Foundation.
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NR 46
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 158
EP 172
DI 10.1016/j.heares.2010.07.010
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200021
PM 20696229
ER
PT J
AU Wu, HP
Guo, YLL
Cheng, TJ
Hsu, CJ
AF Wu, Hung-Pin
Guo, Yueliang Leon
Cheng, Tsun-Jen
Hsu, Chuan-Jen
TI Chronological changes in compromised olivocochlear activity and the
effect of insulin in diabetic Wistar rats
SO HEARING RESEARCH
LA English
DT Article
ID BRAIN-STEM RESPONSES; HEARING-LOSS; GUINEA-PIGS; NOISE; MELLITUS;
BUNDLE; INVOLVEMENT; IMPAIRMENT; EMISSIONS; TONES
AB The aims of the present study were to investigate in diabetic rats: (1) the chronological changes of compromised medial olivocochlear bundle (MOCB) activity and auditory brainstem responses (ABR) and (2) the effect of insulin on diabetes-related hearing dysfunction. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin. Thirty male Wistar rats were divided into three groups: control (C), diabetes with insulin injection (DI), and diabetes without insulin injection (DM). Click-evoked ABR, distortion product otoacoustic emission (DPOAE) and the contralateral suppression (CS) of DPOAE were measured for all animals monthly. Throughout the experiment, the thresholds of click-evoked ABR did not differ among groups. Wave III was delayed and interpeak latency I-III was prolonged in the DM group at the age of 29 weeks (p < 0.05). The amplitudes of the CS of DPOAE were markedly decreased after the 25th week in the DM group, but not in the C and DI groups. Compared to the C group, the CS in the DI group was not attenuated at any frequency. Dysfunction of auditory efferent olivocochlear activity developed in diabetic rats presenting no evidence of hearing loss. The finding of a significant decrease of the CS of DPOAE could be used as an earlier indicator of diabetes-related hearing impairment than changes of ABRs. The time course of compromised MOCB is positively correlated with the duration of diabetes. Insulin could therefore protect against compromised MOCB. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Hsu, Chuan-Jen] Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 10002, Taiwan.
[Guo, Yueliang Leon; Cheng, Tsun-Jen; Hsu, Chuan-Jen] Natl Taiwan Univ, Coll Med, Taipei 10002, Taiwan.
[Wu, Hung-Pin; Guo, Yueliang Leon; Cheng, Tsun-Jen] Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan.
[Wu, Hung-Pin] Buddhist TzuChi Gen Hosp, Taichung Branch, Dept Otolaryngol, Taichung, Taiwan.
[Wu, Hung-Pin] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
[Guo, Yueliang Leon; Cheng, Tsun-Jen] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei 10002, Taiwan.
RP Hsu, CJ (reprint author), Natl Taiwan Univ Hosp, Dept Otolaryngol, 7 Chung Shan S Rd, Taipei 10002, Taiwan.
EM cjhsu@ntu.edu.tw
RI Cheng, Tsun-Jen /D-3495-2012
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NR 35
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC 1
PY 2010
VL 270
IS 1-2
BP 173
EP 178
DI 10.1016/j.heares.2010.07.008
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 707MH
UT WOS:000286290200022
PM 20678565
ER
PT J
AU Zhang, Y
Zhang, WK
Johnston, AH
Newman, TA
Pyykko, I
Zou, J
AF Zhang, Ya
Zhang, Weikai
Johnston, Alexander H.
Newman, Tracey. A.
Pyykko, Ilmari
Zou, Jing
TI Improving the visualization of fluorescently tagged nanoparticles and
fluorophore-labeled molecular probes by treatment with CuSO4 to quench
autofluorescence in the rat inner ear
SO HEARING RESEARCH
LA English
DT Article
ID EMISSIVE POLYMERSOMES; LIPID NANOCAPSULES; IN-VIVO; LIPOFUSCIN; COCHLEA;
COMMUNICATION; BINDING; PROTEIN; MRI
AB Fluorescent tags and fluorophore-conjugated molecular probes have been extensively employed in histological studies to demonstrate nanoparticle distribution in inner ear cell populations. However, autofluorescence that exists in the rodent cochleae disturbs visualization of the fluorescent tags and fluorophore labeling. In the present work, we aimed to improve the visualization of fluorescently tagged nanoparticles and fluorophore-labeled molecular probes by treatment with CuSO4 to quench autofluorescence in the rat inner ear. The in vivo study was performed on eight-to nine-month-old rats using confocal laser scanning microscopy, and the in vitro study was carried out with Dil-tagged poly(ethylene glycol) and poly(capro-lactone) polymersomes and different fluorescent-labeling agents using a spectrofluorometer. The nanoparticles were intratympanically administered using either an osmotic pump or transtympanic injection. Abundant autofluorescence was detected in spiral ganglion cells (SGCs), stria marginal cells, spiral ligament fibrocytes (SL) and the subcuticular cytoplasm of inner hair cells (IHCs). Sparsely distributed faint autofluorescence was also visualized in outer hair cells (OHCs). The autofluorescence was eliminated by treatment with 1 mM CuSO4 (in 0.01 M ammonium acetate buffer) for 70-90 min, while the fluorescent tag in the nanoparticle was absolutely preserved and the labeling fluorescence signals of the molecular probes were mostly retained. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Zhang, Ya; Zhang, Weikai; Pyykko, Ilmari; Zou, Jing] Univ Tampere, Dept Otolaryngol, Sch Med, Tampere 33520, Finland.
[Johnston, Alexander H.; Newman, Tracey. A.] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England.
RP Zou, J (reprint author), Univ Tampere, Dept Otolaryngol, Sch Med, FM1,3rd Floor,Biokatu 6, Tampere 33520, Finland.
EM jing.zou@uta.fi
FU European Community [NMP4-CT-2006-026556]
FX This study was supported by the European Community 6th Framework
Programme on Research, Technological Development and Demonstration
(Nanotechnology-based Targeted Drug Delivery. Contract number:
NMP4-CT-2006-026556, Project acronym: NANOEAR).
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NR 32
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 1
EP 11
DI 10.1016/j.heares.2010.07.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400001
PM 20659540
ER
PT J
AU Smit, JE
Hanekom, T
van Wieringen, A
Wouters, J
Hanekom, JJ
AF Smit, Jacoba E.
Hanekom, Tania
van Wieringen, Astrid
Wouters, Jan
Hanekom, Johan J.
TI Threshold predictions of different pulse shapes using a human auditory
nerve fibre model containing persistent sodium and slow potassium
currents
SO HEARING RESEARCH
LA English
DT Article
ID COCHLEAR IMPLANT USERS; DEPENDENT EXCITABILITY BEHAVIOR; ELECTRICALLY
STIMULATED COCHLEA; ACTION-POTENTIALS; RESPONSE PROPERTIES; ELECTRODE
CONFIGURATION; MONOPHASIC STIMULATION; NEURAL DEGENERATION; MEMBRANE
CURRENTS; SPIRAL GANGLION
AB The ability of a human auditory nerve fibre computational model to predict threshold differences for biphasic, pseudomonophasic and alternating monophasic waveforms was investigated. The effect of increasing the interphase gap, interpulse interval and pulse rate on thresholds was also simulated. Simulations were performed for both anodic-first and cathodic-first stimuli. Results indicated that the model correctly predicted threshold reductions for pseudomonophasic compared to biphasic waveforms, although reduction for alternating monophasic waveforms was underestimated. Threshold reductions were more pronounced for cathodic-first stimuli compared to anodic-first stimuli. Reversal of the phases in pseudomonophasic stimuli suggested a threshold reduction for anodic-first stimuli, but a threshold increase in cathodic-first stimuli. Inclusion of the persistent sodium and slow potassium currents in the model resulted in a reasonably accurate prediction of the non-monotonic threshold behaviour for pulse rates higher than 1000 pps. However, the model did not correctly predict the threshold changes observed for low pulse rate biphasic and alternating monophasic waveforms. It was suggested that these results could in part be explained by the difference in the refractory periods between real and simulated auditory nerve fibres, but also by the lack of representation of stochasticity observed in real auditory nerve fibres in our auditory nerve model. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Smit, Jacoba E.; Hanekom, Tania; Hanekom, Johan J.] Univ Pretoria, Dept Elect Elect & Comp Engn, ZA-0002 Pretoria, South Africa.
[van Wieringen, Astrid; Wouters, Jan] Katholieke Univ Leuven KULeuven, Dept Neurosci, ExpORL, B-3000 Louvain, Belgium.
RP Hanekom, T (reprint author), Univ Pretoria, Dept Elect Elect & Comp Engn, Lynnwood Rd, ZA-0002 Pretoria, South Africa.
EM ksmit@csir.co.za; tania.hanekom@up.ac.za;
Astrid.vanWieringen@med.kuleuven.be; Jan.Wouters@med.kuleuven.be;
johan.hanekom@up.ac.za
RI Wouters, Jan/D-1800-2015
FU National Research Foundation (NRF) of South Africa
FX This research has been supported by the National Research Foundation
(NRF) of South Africa.
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NR 66
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 12
EP 22
DI 10.1016/j.heares.2010.08.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400002
PM 20708672
ER
PT J
AU Scheidt, RE
Kale, S
Heinz, MG
AF Scheidt, Ryan E.
Kale, Sushrut
Heinz, Michael G.
TI Noise-induced hearing loss alters the temporal dynamics of
auditory-nerve responses
SO HEARING RESEARCH
LA English
DT Article
ID SHORT-TERM ADAPTATION; CHRONIC COCHLEAR PATHOLOGY; INNER HAIR CELL;
GUINEA-PIG; STEREOCILIA DAMAGE; RAPID ADAPTATION; LOUDNESS RECRUITMENT;
LEVEL FUNCTIONS; TUNING CURVES; SOUND LEVEL
AB Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal dynamics have been well characterized in auditory-nerve fibers from normal-hearing animals, but little is known about the effects of sensorineural hearing loss on these dynamics. This study examined the effects of noise-induced hearing loss on the temporal dynamics in auditory-nerve fiber responses from anesthetized chinchillas. Post-stimulus-time histograms were computed from responses to 50-ms tones presented at characteristic frequency and 30 dB above fiber threshold. Several response metrics related to temporal dynamics were computed from post-stimulus-time histograms and were compared between normal-hearing and noise-exposed animals. Results indicate that noise-exposed auditory-nerve fibers show significantly reduced response latency, increased onset response and percent adaptation, faster adaptation after onset, and slower recovery after offset. The decrease in response latency only occurred in noise-exposed fibers with significantly reduced frequency selectivity. These changes in temporal dynamics have important implications for temporal envelope coding in hearing-impaired ears, as well as for the design of dynamic compression algorithms for hearing aids. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Heinz, Michael G.] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA.
[Scheidt, Ryan E.] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA.
[Kale, Sushrut; Heinz, Michael G.] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA.
RP Heinz, MG (reprint author), Purdue Univ, Dept Speech Language & Hearing Sci, 500 Oval Dr, W Lafayette, IN 47907 USA.
EM mheinz@purdue.edu
FU National Institutes of Health (NIH)/National Institute on Deafness and
Other Communication Disorders (NIDCD) [R03DC07348, R01DC009838]; Purdue
University
FX This research was supported by grants R03DC07348 and R01DC009838 from
the National Institutes of Health (NIH)/National Institute on Deafness
and Other Communication Disorders (NIDCD). Support was also provided
from Purdue University through a Summer Undergraduate Research
Fellowship (R.S.). The authors thank Gavin Bidelman and Elizabeth
Strickland for valuable comments on previous versions of this
manuscript.
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NR 64
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 23
EP 33
DI 10.1016/j.heares.2010.07.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400003
PM 20696230
ER
PT J
AU Cousineau, M
Demany, L
Meyer, B
Pressnitzer, D
AF Cousineau, Marion
Demany, Laurent
Meyer, Bernard
Pressnitzer, Daniel
TI What breaks a melody: Perceiving FO and intensity sequences with a
cochlear implant
SO HEARING RESEARCH
LA English
DT Article
ID MUSIC PERCEPTION; PITCH DISCRIMINATION; SPEECH RECOGNITION;
NORMAL-HEARING; FUNDAMENTAL-FREQUENCY; ELECTRIC HEARING; ACOUSTIC
HEARING; TEMPORAL PITCH; USERS; CUES
AB Pitch perception has been extensively studied using discrimination tasks on pairs of single sounds. When comparing pitch discrimination performance for normal-hearing (NH) and cochlear implant (Cl) listeners, it usually appears that Cl users have relatively poor pitch discrimination. Tasks involving pitch sequences, such as melody perception or auditory scene analysis, are also usually difficult for Cl users. However, it is unclear whether the issue with pitch sequences is a consequence of sound discriminability, or if an impairment exists for sequence processing per se. Here, we compared sequence processing abilities across stimulus dimensions (fundamental frequency and intensity) and listener groups (NH, Cl, and NH listeners presented with noise-vocoded sequences). The sequence elements were firstly matched in discriminability, for each listener and dimension. Participants were then presented with pairs of sequences, constituted by up to four elements varying on a single dimension, and they performed a same/different task. In agreement with a previous study (Cousineau et al., 2009) fundamental frequency sequences were processed more accurately than intensity sequences by NH listeners. However, this was not the case for Cl listeners, nor for NH listeners presented with noise-vocoded sequences. Intensity sequence processing was, nonetheless, equally accurate in the three groups. These results show that the reduced pitch cues received by Cl listeners do not only elevate thresholds, as previously documented, but also affect pitch sequence processing above threshold. We suggest that efficient sequence processing for pitch requires the resolution of individual harmonics in the auditory periphery, which is not achieved with the current generation of implants. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Cousineau, Marion; Pressnitzer, Daniel] Univ Paris 05, Lab Psychol Percept, CNRS, UMR 8158, F-75006 Paris, France.
[Cousineau, Marion; Pressnitzer, Daniel] Ecole Normale Super, Dept Etud Cognit, F-75005 Paris, France.
[Demany, Laurent] Univ Bordeaux, Lab Mouvement, CNRS, UMR 5227, F-33076 Bordeaux, France.
[Meyer, Bernard] Hop Beaujon, APHP, Serv Otorhinolaryngol, F-92110 Clichy, France.
RP Cousineau, M (reprint author), Univ Paris 05, Lab Psychol Percept, CNRS, UMR 8158, 45 Rue St Peres, F-75006 Paris, France.
EM Marion.Cousineau@ens.fr; laurent.demany@u-bordeaux2.fr;
bernard.meyer@sat.ap-hop-paris.fr; Daniel.Pressnitzer@ens.fr
RI Pressnitzer, Daniel/F-6092-2012; Demany, Laurent/D-7984-2014
OI Demany, Laurent/0000-0001-5549-9628
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NR 44
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 34
EP 41
DI 10.1016/j.heares.2010.07.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400004
PM 20674733
ER
PT J
AU Lin, CY
Wu, JL
Shih, TS
Tsai, PJ
Sun, YM
Ma, MC
Guo, YLL
AF Lin, Cheng-Yu
Wu, Jiunn-Liang
Shih, Tung-Sheng
Tsai, Perng-Jy
Sun, Yih-Min
Ma, Mi-Chia
Guo, Yueliang L.
TI N-Acetyl-cysteine against noise-induced temporary threshold shift in
male workers
SO HEARING RESEARCH
LA English
DT Article
ID INDUCED HEARING-LOSS; GLUTATHIONE-S-TRANSFERASE; LIPID-PEROXIDATION;
COCHLEAR FUNCTION; OXIDATIVE STRESS; THETA GSTT1; INNER-EAR; MICE;
ACETYLCYSTEINE; ANTIOXIDANT
AB Previous animal studies showed protective effects of antioxidant medicines against noise-induced hearing loss (NIHL). It is unclear whether antioxidants would protect humans from NIHL We conducted a study to determine whether N-Acetyl-cysteine (NAC) protected men against noise-induced temporary threshold shift (TTS), and whether subgroups with genetic polymorphisms of glutathione S-transferase (GST) T1 and M1 responded to NAC differently. In this prospective, double-blind, crossover study, 53 male workers were randomly assigned to receive either NAC (1200 mg/day, 14 days) during the first period and placebo during the second period, or placebo during the first period and NAC during the second period. Dosing periods were separated by a washout period of 2 weeks. The hearing threshold changes were determined before and after each dosing period. Pre-shift hearing threshold for high frequencies was 19.1 dB. Daily exposure to noise ranged from 88.4 to 89.4 dB. The noise levels of different frequencies ranged from 80.0 to 89.4 dB with a peak-value at 4 kHz. NAC significantly reduced ITS (p = 0.03). When the participants were grouped by GST M1/T1 genotypes, the NAC effect was only significant among workers with null genotypes in both GSTM1 and GSTT1 (p = 0.004). NAC may prevent noise-induced ITS among occupationally noise-exposed men. The protective effect of NAC was more prominent in subjects with both GSTM1-null and GSM-null genotypes. (clinicaltrials.gov Identifier: NCT00552786) (C) 2010 Elsevier B.V. All rights reserved.
C1 [Guo, Yueliang L.] Natl Taiwan Univ, Dept Environm & Occupat Med, Coll Med, Taipei 100, Taiwan.
[Guo, Yueliang L.] NTU Hosp, Taipei 100, Taiwan.
[Lin, Cheng-Yu] Tainan Hosp, Dept Otolaryngol, Dept Hlth, Tainan 700, Taiwan.
[Lin, Cheng-Yu; Tsai, Perng-Jy] Natl Cheng Kung Univ, Coll Med, Inst Environm & Occupat Hlth Med, Tainan 704, Taiwan.
[Wu, Jiunn-Liang] Natl Cheng Kung Univ, Dept Otolaryngol, Coll Med, Tainan 704, Taiwan.
[Shih, Tung-Sheng] Council Labor Affairs, Inst Occupat Safety & Hlth, Si Jhih City 221, Taipei County, Taiwan.
[Shih, Tung-Sheng] China Med Univ, Coll Publ Hlth, Grad Inst Environm Hlth, Taichung 40202, Taiwan.
[Sun, Yih-Min] Chung Hwa Univ Med Technol, Dept Occupat Safety & Hlth, Ren De Township 717, Tainan County, Taiwan.
[Ma, Mi-Chia] Natl Cheng Kung Univ, Coll Management, Dept Stat, Tainan 701, Taiwan.
RP Guo, YLL (reprint author), Natl Taiwan Univ, Dept Environm & Occupat Med, Coll Med, Room C339,17,Syujhou Rd, Taipei 100, Taiwan.
EM leonguo@ntu.edu.tw
FU Institute of Occupational Safety and Health (JOSH) of the Council of
Labor Affairs in Taiwan
FX The authors thank Miss Wen-Kuei Lin, Miss Linda J. Chang, and the staffs
of the Team Best Company and the Clinico Company who participated in the
study. This study was supported by a grant from the Institute of
Occupational Safety and Health (JOSH) of the Council of Labor Affairs in
Taiwan.
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NR 45
TC 28
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 42
EP 47
DI 10.1016/j.heares.2010.07.005
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400005
PM 20638463
ER
PT J
AU Park, SK
Elmarsafawy, S
Mukherjee, B
Spiro, A
Vokonas, PS
Nie, HL
Weisskopf, MG
Schwartz, J
Hu, H
AF Park, Sung Kyun
Elmarsafawy, Sahar
Mukherjee, Bhramar
Spiro, Avron, III
Vokonas, Pantel S.
Nie, Huiling
Weisskopf, Marc G.
Schwartz, Joel
Hu, Howard
TI Cumulative lead exposure and age-related hearing loss: The VA Normative
Aging Study
SO HEARING RESEARCH
LA English
DT Article
ID NUTRITION EXAMINATION SURVEYS; AUDITORY-EVOKED-POTENTIALS; BLOOD LEAD;
NATIONAL-HEALTH; PLASMA-MEMBRANE; UNITED-STATES; BONE LEAD; ELDERLY-MEN;
NOISE; ADULTS
AB Although lead has been associated with hearing loss in occupational settings and in children, little epidemiologic research has been conducted on the impact of cumulative lead exposure on age-related hearing loss in the general population. We determined whether bone lead levels, a marker of cumulative lead exposure, are associated with decreased hearing ability in 448 men from the Normative Aging Study, seen between 1962 and 1996 (2264 total observations). Air conduction hearing thresholds were measured at 0.25-8 kHz and pure-tone averages (PTA) (mean of 0.5, 1, 2 and 4 kHz) were computed. Tibia and patella lead levels were measured using K X-ray fluorescence between 1991 and 1996. In cross-sectional analyses, after adjusting for potential confounders including occupational noise, patella lead levels were significantly associated with poorer hearing thresholds at 2, 3, 4, 6 and 8 kHz and PTA. The odds of hearing loss significantly increased with patella lead levels. We also found significant positive associations between tibia lead and the rate change in hearing thresholds at 1, 2, and 8 kHz and PTA in longitudinal analyses. Our results suggest that chronic low-level lead exposure may be an important risk factor for age-related hearing loss and reduction of lead exposure could help prevent or delay development of age-related hearing loss. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Park, Sung Kyun; Hu, Howard] Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
[Elmarsafawy, Sahar] Mansoura Univ, Fac Med, Mansoura, Egypt.
[Mukherjee, Bhramar] Univ Michigan, Dept Biostat, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
[Spiro, Avron, III; Vokonas, Pantel S.] Vet Affairs Boston Healthcare Syst, VA Normat Aging Study, Boston, MA USA.
[Spiro, Avron, III] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
[Vokonas, Pantel S.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
[Nie, Huiling] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA.
[Weisskopf, Marc G.; Schwartz, Joel; Hu, Howard] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
RP Park, SK (reprint author), Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, 1415 Washington Hts,SPH 2-M6240, Ann Arbor, MI 48109 USA.
EM sungkyun@umich.edu
FU National Institute of Environment Health Sciences (NIEHS) [K01-ES016587,
R01-ES05257, P42-ES05947, P30-ES00002]; Center for Occupational Health
and Safety Engineering (COHSE) at the University of Michigan; Centers
for Disease Control and Prevention/National Institute for Occupational
Safety and Health [2T420H008455]; VA Merit Review; Epidemiology Research
and Information Center of the U.S. Department of Veterans Affairs
FX This work was supported by the National Institute of Environment Health
Sciences (NIEHS) grants K01-ES016587, R01-ES05257, P42-ES05947 and
P30-ES00002. This research was also supported in part by a pilot project
research training grant from the Center for Occupational Health and
Safety Engineering (COHSE) at the University of Michigan. COHSE an
Education and Research Center, is supported by Training Grant No.
2T420H008455 from the Centers for Disease Control and
Prevention/National Institute for Occupational Safety and Health. The
contents are solely the responsibility of the author(s) and do not
necessarily represent the official views of the National Institute for
Occupational Safety and Health. Dr. Spiro was supported by a VA Merit
Review. The VA Normative Aging Study is supported by the Cooperative
Studies Program/Epidemiology Research and Information Center of the U.S.
Department of Veterans Affairs and is a component of the Massachusetts
Veterans Epidemiology Research and Information Center, Boston,
Massachusetts.
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NR 49
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 48
EP 55
DI 10.1016/j.heares.2010.07.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400006
PM 20638461
ER
PT J
AU Brittan-Powell, EE
Dooling, RJ
Ryals, B
Gleich, O
AF Brittan-Powell, Elizabeth E.
Dooling, Robert J.
Ryals, Brenda
Gleich, Otto
TI Electrophysiological and morphological development of the inner ear in
Belgian Waters lager canaries
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY-BRAIN-STEM; GERBIL MERIONES-UNGUICULATUS; HAIR CELL
REGENERATION; BUDGERIGARS MELOPSITTACUS-UNDULATUS; ANTEROVENTRAL
COCHLEAR NUCLEUS; SENSORINEURAL HEARING-LOSS; AGE-RELATED-CHANGES;
SERINUS-CANARIUS; EVOKED POTENTIALS; MONGOLIAN GERBIL
AB Belgian Waterslager (BW) canaries have an inherited hearing loss due to missing and abnormal hair cells, but it is unclear whether the loss is congenital or developmental. We used auditory brainstem responses and scanning electron microscopy to describe the development of auditory sensitivity and hair cell abnormalities in BW and non-BW canaries. In both strains, adult ABR thresholds were higher than behavioral thresholds, but BW canaries exhibited higher thresholds than non-BW canaries across all frequencies. Immediately post-hatch, ABR thresholds and hair cell numbers were similar in both strains. Two weeks later, thresholds were significantly higher in BW canaries, and hair cell number progressively decreased as the birds aged. These data show that in BW canaries: the peripheral auditory system is functionally similar to non-BW canary from hatch to 2 weeks, ABR thresholds improve during this developmental period, actually becoming better than those of adults, but then worsen as the bird continues to age. Hair cell number and appearance is similar to non-BW canaries at hatch but progressively declines after 30 days of age. These data show that the hearing loss characteristic of BW canaries is, at least in part, developmental and is established by the time song learning begins. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Brittan-Powell, Elizabeth E.; Dooling, Robert J.] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Brittan-Powell, Elizabeth E.; Dooling, Robert J.] Univ Maryland, Ctr Comparat & Evolutionary Biol Hearing, College Pk, MD 20742 USA.
[Ryals, Brenda] James Madison Univ, Dept Commun Sci & Disorders, Harrisonburg, VA 22807 USA.
[Gleich, Otto] Univ Regensburg, ENT Dept, D-93042 Regensburg, Germany.
RP Brittan-Powell, EE (reprint author), Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
EM bbrittanpowell@psyc.umd.edu
FU National Institute of Deafness and Communicative Disorders of the
National Institutes of Health [DC-001372, P30DC004664]
FX The authors would like to thank Amanda Lauer and Peter Marvit for
comments on earlier drafts and Fernando Nottebohm for use of BW canaries
from Rockefeller University Field Station. This work was supported in
part by grant DC-001372 from the National Institute of Deafness and
Communicative Disorders of the National Institutes of Health to RJD and
BMR and P30DC004664.
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NR 69
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 56
EP 69
DI 10.1016/j.heares.2010.07.003
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400007
PM 20638464
ER
PT J
AU Songer, JE
Rosowski, JJ
AF Songer, Jocelyn E.
Rosowski, John J.
TI A superior semicircular canal dehiscence-induced air-bone gap in
chinchilla
SO HEARING RESEARCH
LA English
DT Article
ID CONDUCTIVE HEARING-LOSS; MIDDLE-EAR; SOUND; ADMITTANCE; MECHANISMS;
COCHLEA; VERTIGO; MODEL
AB An SCD is a pathologic hole (or dehiscence) in the bone separating the superior semicircular canal from the cranial cavity that has been associated with a conductive hearing loss in patients with SCD syndrome. The conductive loss is defined by an audiometrically determined air-bone gap that results from the combination of a decrease in sensitivity to air-conducted sound and an increase in sensitivity to bone-conducted sound. Our goal is to demonstrate, through physiological measurements in an animal model, that mechanically altering the superior semicircular canal (SC) by introducing a hole (dehiscence) is sufficient to cause such an air-bone gap. We surgically introduced holes into the SC of chinchilla ears and evaluated auditory sensitivity (cochlear potential) in response to both air- and bone-conducted stimuli. The introduction of the SC hole led to a low-frequency (<2000 Hz) decrease in sensitivity to air-conducted stimuli and a low-frequency (<1000 Hz) increase in sensitivity to bone-conducted stimuli resulting in an air-bone gap. This result was consistent and reversible. The air-bone gaps in the animal results are qualitatively consistent with findings in patients with SCD syndrome. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Songer, Jocelyn E.; Rosowski, John J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, Boston, MA 02114 USA.
[Songer, Jocelyn E.; Rosowski, John J.] Harvard MIT, Cambridge, MA 02138 USA.
[Rosowski, John J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Songer, JE (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, 243 Charles St, Boston, MA 02114 USA.
EM jocelyns@mit.edu
FU NSF; NIH [T32-DC00038, R01-DC000194]
FX This work has been supported by an NSF graduate student fellowship. NIH
training grant T32-DC00038, and an additional NIH research grant
R01-DC000194. S. Merchant and W. Peake, and M.E. Ravicz provided
insights and suggestions. M. Wood assisted with data collection and
animal surgery.
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NR 32
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 70
EP 80
DI 10.1016/j.heares.2010.07.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400008
PM 20638462
ER
PT J
AU Gander, RE
Bosnyak, DJ
Roberts, LE
AF Gander, R. E.
Bosnyak, D. J.
Roberts, L. E.
TI Acoustic experience but not attention modifies neural population phase
expressed in human primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
ID AMPLITUDE-MODULATED TONES; STEADY-STATE RESPONSES; EVOKED-POTENTIALS;
BRAIN-STEM; MUSICAL EXPERIENCE; BASAL FOREBRAIN; NON-MUSICIANS;
PLASTICITY; FREQUENCY; FIELDS
AB We studied the effect of auditory training on the 40-Hz auditory steady-state response (ASSR) known to localize tonotopically to the region of primary auditory cortex (A1). The stimulus procedure was designed to minimize competitive interactions among frequency representations in A1 and delivered target events at random times in a training window, to increase the likelihood that neuroplastic changes could be detected. Experiment 1 found that repeated exposure to this stimulus advanced the phase of the ASSR (shortened the time delay between the 40-Hz response and stimulus waveforms). The phase advance appeared at the outset of the second of two sessions separated by 24-72 h, did not require active training, and was not accompanied by changes in ASSR amplitude over this time interval. Experiment 2 applied training for 10 sessions to reveal further advances in ASSR phase and also an increase in ASSR amplitude, but the amplitude effect lagged that on phase and did not correlate with perceptual performance while the phase advance did. A control group trained for a single session showed a phase advance but no amplitude enhancement when tested 6 weeks later (retention). In both experiments attention to auditory signals increased ASSR amplitude but had no effect on ASSR phase. Our results reveal a persistent form of neural plasticity expressed in the phase of ASSRs generated from the region of A1, which occurs either in A1 or in subcortical nuclei projecting to this region. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Gander, R. E.; Bosnyak, D. J.; Roberts, L. E.] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada.
RP Roberts, LE (reprint author), McMaster Univ, Dept Psychol Neurosci & Behav, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.
EM pgander@mcmaster.ca; bosnyak@mcmaster.ca; roberts@mcmaster.ca
FU Canadian Institutes of Health Research; Natural Sciences and Engineering
Research Council of Canada
FX This research was supported by grants from the Canadian Institutes of
Health Research and the Natural Sciences and Engineering Research
Council of Canada (LER). The authors contributed equally to this work.
PEG, is now at the University of Nottingham (UK).
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NR 72
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 81
EP 94
DI 10.1016/j.heares.2010.07.001
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400009
ER
PT J
AU Schaette, R
Konig, O
Hornig, D
Gross, M
Kempter, R
AF Schaette, Roland
Koenig, Ovidiu
Hornig, Dirk
Gross, Manfred
Kempter, Richard
TI Acoustic stimulation treatments against tinnitus could be most effective
when tinnitus pitch is within the stimulated frequency range
SO HEARING RESEARCH
LA English
DT Article
ID DORSAL COCHLEAR NUCLEUS; HEARING-AID USE; COMPUTATIONAL MODEL; NEURONAL
HYPERACTIVITY; SUBJECTIVE TINNITUS; ADAPTIVE PLASTICITY; BRAIN-STEM;
VARIABILITY; ENVIRONMENT; PERCEPTION
AB Acoustic stimulation with hearing aids or noise devices is frequently used in tinnitus therapy. However, such behind-the-ear devices are limited in their high-frequency output with an upper cut-off frequency of approximately 5-6 kHz. Theoretical modeling suggests that acoustic stimulation treatments with these devices might be most effective when the tinnitus pitch is within the stimulated frequency range. To test this hypothesis, we conducted a pilot study with 15 subjects with chronic tinnitus. Eleven subjects received hearing aids and four subjects noise devices. Perceived tinnitus loudness was measured using a visual analog scale, and tinnitus-related distress was assessed using the Tinnitus Questionnaire. After six months of device usage, reductions of perceived tinnitus loudness were seen only in subjects with a tinnitus pitch of less than 6 kHz. When subjects were grouped by tinnitus pitch, the group of patients with a tinnitus pitch of less than 6 kHz (n = 10 subjects) showed a significant reduction in perceived tinnitus loudness (from 73.4 +/- 6.1 before to 56.4 +/- 7.4 after treatment, p = 0.012), whereas in subjects with a tinnitus pitch of 6 kHz or more (n = 5 subjects) tinnitus loudness was slightly increased after six months of treatment (65.0 +/- 4.7 before and 70.6 +/- 5.9 after treatment), but the increase was not significant (p = 0.063). Likewise, tinnitus-related distress was significantly decreased in the low-pitch group (from 31.6 +/- 4.3 to 20.9 +/- 4.8, p = 0.0059), but not in the group with high-pitched tinnitus (30.2 +/- 3.3 before and 30.0 +/- 5.1 after treatment, p = 1). Overall, reductions in tinnitus-related distress in our study were less pronounced than those reported for more comprehensive treatments. However, the differences we observed between the low- and the high-pitch group show that tinnitus pitch might influence the outcome of acoustic stimulation treatments when devices with a limited frequency range are used. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Schaette, Roland] UCL, UCL Ear Inst, London WC1X 8EE, England.
[Schaette, Roland; Kempter, Richard] Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany.
[Schaette, Roland; Kempter, Richard] Bernstein Ctr Computat Neurosci Berlin, D-10115 Berlin, Germany.
[Koenig, Ovidiu; Hornig, Dirk; Gross, Manfred] Charite, Med Fac Berlin, Dept Audiol & Phoniatr, D-13353 Berlin, Germany.
[Kempter, Richard] Charite, Med Fac Berlin, Neurosci Res Ctr, D-10117 Berlin, Germany.
RP Schaette, R (reprint author), UCL, UCL Ear Inst, 332 Grays Inn Rd, London WC1X 8EE, England.
EM r.schaette@ucl.ac.uk
FU Deutsche Forschungsgemeinschaft (DFG) [Ke 788/1-4]; Bundesministerium
fur Bildung und Forschung (Bernstein Center for Computational
Neuroscience Berlin) [01GQ0410, 01GQ07102]; British Tinnitus
Association; [SFB 618]
FX This research was supported by the Deutsche Forschungsgemeinschaft (DFG)
through the Emmy Noether Programm (Ke 788/1-4), the SFB 618 "Theoretical
Biology", the Bundesministerium fur Bildung und Forschung (Bernstein
Center for Computational Neuroscience Berlin, 01GQ0410; Bernstein
Collaboration "Temporal Precision", 01GQ07102), and the British Tinnitus
Association.
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NR 45
TC 35
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 95
EP 101
DI 10.1016/j.heares.2010.06.022
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400010
PM 20619332
ER
PT J
AU Rajguru, SM
Matic, AI
Robinson, AM
Fishman, AJ
Moreno, LE
Bradley, A
Vujanovic, I
Breen, J
Wells, JD
Bendett, M
Richter, CP
AF Rajguru, Suhrud M.
Matic, Agnella Izzo
Robinson, Alan M.
Fishman, Andrew J.
Moreno, Laura E.
Bradley, Allison
Vujanovic, Irena
Breen, Joe
Wells, Jonathon D.
Bendett, Mark
Richter, Claus-Peter
TI Optical cochlear implants: Evaluation of surgical approach and laser
parameters in cats
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY-NERVE FIBERS; INTRACOCHLEAR ELECTRICAL-STIMULATION; INNER-EAR;
SPEECH RECOGNITION; APICAL DIFFERENCES; PULSE DURATION; HEARING;
CHANNELS; RECEPTOR; POTENTIALS
AB Previous research has shown that neural stimulation with infrared radiation (IR) is spatially selective and illustrated the potential of IR in stimulating auditory neurons. The present work demonstrates the application of a miniaturized pulsed IR stimulator for chronic implantation in cats, quantifies its efficacy, and short-term safety in stimulating auditory neurons. IR stimulation of the neurons was achieved using an optical fiber inserted through a cochleostomy drilled in the basal turn of the cat cochlea and was characterized by measuring compound action potentials (CAPs). Neurons were stimulated with IR at various pulse durations, radiant exposures, and pulse repetition rates. Pulse durations as short as 50 us were successful in evoking CAPs in normal as well as deafened cochleae. Continual stimulation was provided at 200 pulses per second, at 200 mW per pulse, and 100 us pulse duration. Stable CAP amplitudes were observed for up to 10 h of continual IR stimulation. Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Rajguru, Suhrud M.; Matic, Agnella Izzo; Robinson, Alan M.; Fishman, Andrew J.; Moreno, Laura E.; Bradley, Allison; Vujanovic, Irena; Breen, Joe; Richter, Claus-Peter] Northwestern Univ, Dept Otolaryngol Head & Neck Surg, Feinberg Sch Med, Chicago, IL 60611 USA.
[Fishman, Andrew J.] Northwestern Univ, Dept Neurosurg, Feinberg Sch Med, Chicago, IL 60611 USA.
[Bradley, Allison; Richter, Claus-Peter] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA.
[Fishman, Andrew J.; Richter, Claus-Peter] Northwestern Univ, Hugh Knowles Ctr, Dept Commun Sci & Disorders, Evanston, IL 60208 USA.
[Wells, Jonathon D.; Bendett, Mark] Lockheed Martin Aculight, Bothell, WA USA.
RP Richter, CP (reprint author), Northwestern Univ, Dept Otolaryngol Head & Neck Surg, Feinberg Sch Med, Searle Bldg 12-561,303 E Chicago Ave, Chicago, IL 60611 USA.
EM cri529@northwestern.edu
FU National Institutes of Health [1R41DC008515-02]
FX The care and use of adult cats in this study was carried out in
accordance with the NIH Guide for the Care and Use of Laboratory Animals
and was approved by the Animal Care and Use Committee of Northwestern
University. This work was funded by National Institutes of Health grant
1R41DC008515-02.
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NR 34
TC 39
Z9 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 102
EP 111
DI 10.1016/j.heares.2010.06.021
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400011
PM 20603207
ER
PT J
AU Boul, A
Lineton, B
AF Boul, Alison
Lineton, Ben
TI Spontaneous otoacoustic emissions measured using an open ear-canal
recording technique
SO HEARING RESEARCH
LA English
DT Article
ID OTO-ACOUSTIC EMISSIONS; MIDDLE-EAR; WAVES; PREVALENCE; REFLECTION;
IMPEDANCE; AMPLITUDE; COCHLEA; SYSTEM
AB Spontaneous otoacoustic emissions (SOAEs) and synchronized spontaneous otoacoustic emissions (SSOAEs) were recorded using both the standard closed-canal method of recording and a novel open-canal method which involved suspending the probe at the entrance to the ear canal with no occluding tip. In both conditions, a probe tube microphone was inserted down the ear canal to measure the acoustic pressure near the tympanic membrane. Open- and closed-canal recordings were obtained in twelve otologically normal ears, all of which exhibited SSOAEs, and 6 of which exhibited SOAEs. The results were analysed to identify any differences in response to frequency and amplitude. The different recording conditions appeared to have no significant effect on SOAE or SSOAE frequency, suggesting little effect on the SOAE generator within the cochlea. Below about 2 kHz, the amplitude for both types of emission was less for the open-canal recording when compared to the closed-canal recordings. Above 2 kHz, SSOAE amplitudes were greater in the open- than the closed-canal condition. Model stimulations of the ear canal and middle-ear acoustics are presented which were in qualitative agreement with the results shown for the effects on emission amplitudes. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
C1 [Boul, Alison; Lineton, Ben] Univ Southampton, Inst Sound & Vibrat Res, Southampton SO16 7PX, Hants, England.
RP Boul, A (reprint author), Aston Univ, Midlands Cochlear Implant Programme, Childrens Serv, Aston Univ Day Hosp, Birmingham B4 7ET, W Midlands, England.
EM alison.boul@bch.nhs.uk; bl@isvr.soton.ac.uk
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NR 34
TC 0
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 112
EP 121
DI 10.1016/j.heares.2010.06.020
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400012
PM 20600736
ER
PT J
AU Liu, P
Zhang, H
Devaraj, R
Ganesalingam, GS
Smith, PF
AF Liu, Ping
Zhang, Hu
Devaraj, Renuka
Ganesalingam, Ganes S.
Smith, Paul F.
TI A multivariate analysis of the effects of aging on glutamate, GABA and
arginine metabolites in the rat vestibular nucleus
SO HEARING RESEARCH
LA English
DT Article
ID AGE-RELATED-CHANGES; NITRIC-OXIDE SYNTHASE; VESTIBULOOCULAR REFLEX; HAIR
CELL; MICROSCOPIC EVALUATION; ALZHEIMERS-DISEASE; CRISTA-AMPULLARIS;
OLDER-PEOPLE; NOS ACTIVITY; GUINEA-PIG
AB Aging is associated with neurochemical changes in the brain that result in impaired vestibular reflex function. We analysed the concentrations of 9 related neurochemicals (L-arginine, L-citrulline, L-ornithine, agmatine, putrescine, spermidine, spermine, glutamate and gamma-aminobutyric acid (GABA)) in the vestibular nucleus of aged (24 months old) and young (4 month old) rats; the cerebellum was analysed for comparison. The effects of the housing conditions of the rats were also investigated. Age significantly affected the concentrations of the 9 neurochemicals in both the vestibular nucleus and cerebellum (P = 0.000). Housing did not have a significant effect and the interaction between age and housing was significant only for the vestibular nucleus (P = 0.03). For both the vestibular nucleus and cerebellum, linear discriminant functions were identified that significantly predicted whether the animals were 4 or 24 months old (P = 0.000). Using multiple regression analysis, only vestibular nucleus spermidine, spermine and L-arginine could be predicted from the other neurochemical variables with an adjusted R(2) of >80%. Cluster analyses were performed to determine if the neurochemical variables formed distinct groups and whether this changed as a function of age. For the vestibular nucleus but not the cerebellum, the clusters were substantially different for the 24 month old and 4 month old animals. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Smith, Paul F.] Univ Otago, Dept Pharmacol & Toxicol, Dunedin, New Zealand.
[Liu, Ping; Devaraj, Renuka] Univ Otago, Dept Anat & Struct Biol, Dunedin, New Zealand.
[Zhang, Hu] Univ Otago, Sch Pharm, Dunedin, New Zealand.
[Ganesalingam, Ganes S.] Massey Univ, Inst Fundamental Sci, Palmerston North, New Zealand.
RP Smith, PF (reprint author), Univ Otago, Dept Pharmacol & Toxicol, Dunedin, New Zealand.
EM paul.smith@stonebow.otago.ac.nz
FU New Zealand Neurological Foundation; Lottery Health Board
FX This research was supported by grants from the New Zealand Neurological
Foundation and Lottery Health Board to PL
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NR 82
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 122
EP 133
DI 10.1016/j.heares.2010.06.019
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400013
PM 20600737
ER
PT J
AU Greene, NT
Lomakin, O
Davis, KA
AF Greene, Nathaniel T.
Lomakin, Oleg
Davis, Kevin A.
TI Monaural spectral processing differs between the lateral superior olive
and the inferior colliculus: Physiological evidence for an acoustic
chiasm
SO HEARING RESEARCH
LA English
DT Article
ID DORSAL COCHLEAR NUCLEUS; LOW-FREQUENCY NEURONS; INTERAURAL TIME
DIFFERENCES; SPATIAL RECEPTIVE-FIELDS; SINGLE AUDITORY UNITS; RESPONSE
PROPERTIES; BINAURAL INTERACTION; DECEREBRATE CATS; S-SEGMENT;
DISCRIMINATION THRESHOLDS
AB Evidence suggests that the lateral superior olive (LSO) initiates an excitatory pathway specialized to process interaural level differences (ILDs), the primary cues used by mammals to localize high-frequency sounds in the horizontal plane. Type I units in the central nucleus of the inferior colliculus (ICC) of decerebrate cats exhibit monaural and binaural response properties qualitatively similar to those of LSO units, and are thus supposed to be the midbrain component of the ILD pathway. Studies have shown, however, that the responses of ICC cells do not often reflect simply the output of any single source of excitatory inputs. The goal of this study was to compare directly the monaural, spectral response properties of LSO and type I units measured in unanesthetized decerebrate cats. Compared to LSO units, type 1 units have narrower V-shaped excitatory tuning curves, higher spontaneous rates, lower maximum stimulus-evoked firing rates and more nonmonotonic rate-level curves for tones and noise. In addition, low-frequency type I units have lower thresholds to tones than corresponding LSO units. Taken together, these results suggest that the excitatory ILD pathway from LSO to ICC is mostly a high-frequency channel, and that additional inputs transform LSO influences in the ICC. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Greene, Nathaniel T.; Lomakin, Oleg; Davis, Kevin A.] Univ Rochester, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
[Greene, Nathaniel T.; Lomakin, Oleg; Davis, Kevin A.] Univ Rochester, Dept Biomed Engn, Rochester, NY 14642 USA.
[Greene, Nathaniel T.; Lomakin, Oleg; Davis, Kevin A.] Univ Rochester, Ctr Nav & Commun Sci, Rochester, NY 14642 USA.
RP Davis, KA (reprint author), Univ Rochester, Dept Neurobiol & Anat, 601 Elmwood Ave,Box 603, Rochester, NY 14642 USA.
EM kevin_davis@urmc.rochester.edu
FU National Institute of Deafness and Other Communication Disorders
[DC05161]
FX This work was supported by National Institute of Deafness and Other
Communication Disorders grant DC05161.
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NR 75
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 134
EP 145
DI 10.1016/j.heares.2010.06.018
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400014
PM 20600738
ER
PT J
AU Undurraga, JA
van Wieringen, A
Carlyon, RP
Macherey, O
Wouters, J
AF Undurraga, Jaime A.
van Wieringen, Astrid
Carlyon, Robert P.
Macherey, Olivier
Wouters, Jan
TI Polarity effects on neural responses of the electrically stimulated
auditory nerve at different cochlear sites
SO HEARING RESEARCH
LA English
DT Article
ID ACTION-POTENTIALS; MONOPHASIC STIMULATION; IMPLANT USERS; PULSE SHAPES;
GUINEA-PIG; WAVE-FORM; SENSITIVITY; HEARING; SYSTEM; FIBER
AB Three experiments studied the effect of stimulus polarity on the Electrically Evoked Compound Action Potential (ECAP) obtained with the masker-probe paradigm on different sites along the cochlea in cochlear implant users. Experiment 1 used a biphasic cathodic-1st (BIC) masker and showed that ECAP N(1) peak latencies were longer for BIC than for biphasic anodic-1st (BIA) probes on all electrodes under test. Both the latency of each probe as well as the latency difference between BIA and BIC probes increased when the phase width (PW) of the masker and probe were increased together. Experiment 2 used maskers with long inter-phase gaps (IPGs), and, by manipulating the polarity of the second phase (closest in time to the biphasic probe), showed that only an anodic phase could mask the probe response. Experiment 3 used maskers and probes with long IPGs and measured ECAPs to the first phase of the probe; ECAPs could be measured when both this phase and the second phase of the masker were anodic, but not when they were cathodic. Our results extend those of a previous study, showing that the auditory nerve in humans is preferentially activated by anodic stimulation, to different sites along the cochlea. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Undurraga, Jaime A.; van Wieringen, Astrid; Wouters, Jan] Katholieke Univ Leuven KULeuven, Dept Neurosci, ExpORL, B-3000 Louvain, Belgium.
[Carlyon, Robert P.; Macherey, Olivier] MRC Cognit & Brain Sci Unit, Cambridge CB2 7EF, England.
RP Undurraga, JA (reprint author), Katholieke Univ Leuven KULeuven, Dept Neurosci, ExpORL, Herestr 49 Bus 721, B-3000 Louvain, Belgium.
EM jaime.undurraga@med.kuleuven.be
RI Wouters, Jan/D-1800-2015
FU Research Council of the Katholieke Universiteit Leuven [OT/07/056]
FX This research is supported by the OT grant from the Research Council of
the Katholieke Universiteit Leuven (OT/07/056) and is approved by the
Local Research Ethics Committee of the Katholieke Universiteit Leuven/UZ
Leuven.
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NR 43
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 146
EP 161
DI 10.1016/j.heares.2010.06.017
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400015
PM 20600739
ER
PT J
AU Drgas, S
Blaszak, MA
AF Drgas, Szymon
Blaszak, Magdalena A.
TI Perception of speech in reverberant conditions using AM-FM cochlear
implant simulation
SO HEARING RESEARCH
LA English
DT Article
ID FREQUENCY-MODULATION; SYNTHETIC SPEECH; NOISE; RECOGNITION; PERFORMANCE;
HEARING; TIMES; INTELLIGIBILITY; IDENTIFICATION; LISTENERS
AB This study assessed the effects of speech misidentification and cognitive processing errors in normal-hearing adults listening to degraded auditory input signals simulating cochlear implants in reverberation conditions.
Three variables were controlled: number of vocoder channels (six and twelve), instantaneous frequency change rate (none, 50, 400 Hz), and enclosures (different reverberation conditions). The analyses were made on the basis of: (a) nonsense word recognition scores for eight young normalhearing listeners, (b) 'ease of listening' based on the time of response, and (c) the subjective measure of difficulty.
The maximum score of speech intelligibility in cochlear implant simulation was 70% for non-reverberant conditions with a 12-channel vocoder and changes of instantaneous frequency limited to 400 Hz. In the presence of reflections, word misidentification was about 10-20 percentage points higher. There was little difference between the 50 and 400 Hz frequency modulation cut-off for the 12-channel vocoder; however, in the case of six channels this difference was more significant.
The results of the experiment suggest that the information other than FO, that is carried by FM, can be sufficient to improve speech intelligibility in the real-world conditions. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Drgas, Szymon; Blaszak, Magdalena A.] Adam Mickiewicz Univ Poznan, Inst Acoust, Fac Phys, PL-60769 Poznan, Poland.
[Drgas, Szymon] Poznan Tech Univ, Chair Control & Syst Engn, Poznan, Poland.
[Blaszak, Magdalena A.] Univ Warsaw, Fac Phys, Dept Biomed Phys, Warsaw, Poland.
RP Drgas, S (reprint author), Adam Mickiewicz Univ Poznan, Inst Acoust, Fac Phys, Umultowska 85, PL-60769 Poznan, Poland.
EM Szymon.Drgas@put.poznan.pl; blasaku@gmail.com
RI Drgas, Szymon/F-7719-2014
CR [Anonymous], 33821997 ISO
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NR 33
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 162
EP 168
DI 10.1016/j.heares.2010.06.016
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400016
PM 20603206
ER
PT J
AU Agterberg, MJH
Versnel, H
de Groot, JCMJ
van den Broek, M
Klis, SFL
AF Agterberg, Martijn J. H.
Versnel, Huib
de Groot, John C. M. J.
van den Broek, Marloes
Klis, Sjaak F. L.
TI Chronic electrical stimulation does not prevent spiral ganglion cell
degeneration in deafened guinea pigs
SO HEARING RESEARCH
LA English
DT Article
ID FIBROBLAST-GROWTH-FACTOR; NEUROTROPHIC FACTOR; AUDITORY-NERVE; COCHLEAR
IMPLANTS; INNER-EAR; NEONATAL DEAFNESS; TROPHIC SUPPORT; NEURON
SURVIVAL; HAIR-CELLS; CATS
AB Several studies have demonstrated that treatment with intracochlear chronic electrical stimulation (CES) protects spiral ganglion cells (SGCs) from degeneration in deafened animals. Other studies could not confirm this effect of CES. The present study examined whether CES in a mode as presented in cochlear implant users (amplitude modulated, high pulse rate) affects survival, morphology and functionality of SGCs in deafened guinea pigs. Eleven guinea pigs were implanted in the right cochlea with an electrode array to monitor the electrically evoked auditory brainstem responses (eABRs). The guinea pigs were deafened four weeks later. Two days after deafening, monopolar CES was started in five animals through three electrodes in the basal cochlear turn. CES lasted 4 hours per day, five days per week, for six weeks. SGC packing densities, perikaryal area, cell circularity, amplitudes of suprathreshold eABRs and eABR thresholds were not affected by CES. SGCs of all implanted cochleae were larger and more circular than SGCs in unimplanted cochleae, but this did not depend on CES treatment. Interestingly, an increase in eABR latencies observed after deafening, occurred faster in CES-treated than in untreated animals. In conclusion, amplitude-modulated chronic electrical stimulation with a high pulse rate does not affect survival, morphology and functionality of spiral ganglion cells with the exception of eABR latencies. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Agterberg, Martijn J. H.; Versnel, Huib; de Groot, John C. M. J.; van den Broek, Marloes; Klis, Sjaak F. L.] Univ Med Ctr Utrecht, Dept Otorhinolaryngol & Head & Neck Surg, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands.
[Agterberg, Martijn J. H.] Radboud Univ Nijmegen, Dept Biophys, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands.
RP Klis, SFL (reprint author), Univ Med Ctr Utrecht, Dept Otorhinolaryngol & Head & Neck Surg, Room G-02-531,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM s.klis@umcutrecht.nl
RI Agterberg, Martijn/K-2956-2012
FU Heinsius-Houbolt Foundation
FX The authors would like to thank Rik Mansvelt-Beck for his excellent
technical assistance, Ferry Hendriksen for assisting with histology,
Rene van de Vosse for the recording and analysis software, and Victor
Wiegant for his comments concerning the manuscript. Furthermore, we
would like to thank Bas van Dijk and the Cochlear (TM) company for
providing the electrode arrays and the implant-in-a-box. This study was
supported by the Heinsius-Houbolt Foundation.
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NR 64
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 169
EP 179
DI 10.1016/j.heares.2010.06.015
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400017
PM 20600740
ER
PT J
AU Mhatre, AN
Tajudeen, B
Welt, EM
Wartmann, C
Long, GR
Lalwani, AK
AF Mhatre, Anand N.
Tajudeen, Bobby
Welt, Elena M.
Wartmann, Christopher
Long, Glenis R.
Lalwani, Anil K.
TI Temporary reduction of distortion product otoacoustic emissions (DPOAEs)
immediately following auditory brainstem response (ABR)
SO HEARING RESEARCH
LA English
DT Article
ID INDUCED HEARING-LOSS; SUPEROXIDE-DISMUTASE; TRANSGENIC MICE; NOISE;
MUTATIONS; OVEREXPRESSION; CADHERIN-23; CDH23; SUSCEPTIBILITY;
STEREOCILIA
AB The hearing status of an experimental animal is typically assessed in the laboratory setting by the combined use of auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs), carried out in succession, with the former assay preceding the latter. This study reports a cautionary finding that the use of this accepted regimen yields a reduced DPOAE response. When the DPOAEs were performed after ABR testing, transient reduction of the DPOAE amplitudes was observed at all frequencies in both the inbred, C57/B6 and FVB/N, and the outbred, SW mouse strains. DPOAEs were reduced post-ABR in multiple mouse strains which suggests that this finding is not strain-specific but a general consequence of the preceding ABR analysis. The reduction in DPOAE was temporary: when re-tested at one hour, DPOAE amplitudes recovered to pre-ABR levels. In contrast to the ABR's impact on DPOAE response, ABR thresholds were not altered or reduced when preceded immediately by DPOAE measurements. The molecular alterations underlying the ABR-induced transient reduction of DPOAE remain to be determined. To investigate the potential role of reactive oxygen species in post-ABR DPOAE reduction, transgenic mice over-expressing SOD1, the cytoplasmic enzyme critical for removal of superoxide radicals were subjected to the same auditory testing regimen. Similar to their wild type littermates, the SOD1 transgenic mice also demonstrated post-ABR DPOAE reduction, and thus do not support a role for superoxide radicals in transient reduction of DPOAE. While toxic noise exposure is known to negatively impact OAE, transient decrease in DPOAE levels following standard ABR assay has not been previously described. A practical outcome from this study is a recommendation for reversal of the traditional order for carrying out auditory tests, with the OAE measurements preceding ABR assessment, thus ensuring that the DPOAE response is unaffected. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Mhatre, Anand N.; Tajudeen, Bobby; Welt, Elena M.; Wartmann, Christopher] NYU, Dept Otolaryngol, Sch Med, Mol Genet Lab, New York, NY 10016 USA.
[Tajudeen, Bobby; Welt, Elena M.; Wartmann, Christopher; Lalwani, Anil K.] NYU, Dept Otolaryngol, Sch Med, Lab Mol Otol, New York, NY 10016 USA.
[Mhatre, Anand N.; Lalwani, Anil K.] NYU, Dept Physiol & Neurosci, Sch Med, New York, NY 10016 USA.
[Lalwani, Anil K.] NYU, Dept Pediat, Sch Med, New York, NY 10016 USA.
[Long, Glenis R.] CUNY, Grad Ctr, New York, NY 10016 USA.
RP Mhatre, AN (reprint author), NYU, Dept Otolaryngol, Sch Med, Mol Genet Lab, 560 1st Ave,Skirball 8S, New York, NY 10016 USA.
EM anand.mhatre@nyumc.org; anil.lalwani@nyumc.org
FU NIDCD [DC005199]; Deafness Research Foundation
FX This study was supported in part by the NIDCD (DC005199) and the
Deafness Research Foundation. We thank Dr. Marcin Wroblewski for his
help with statistical analysis of our data.
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NR 29
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT 1
PY 2010
VL 269
IS 1-2
BP 180
EP 185
DI 10.1016/j.heares.2010.06.012
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 658ON
UT WOS:000282499400018
PM 20600743
ER
PT J
AU Borkholder, DA
Zhu, XX
Hyatt, BT
Archilla, AS
Livingston, WJ
Frisina, RD
AF Borkholder, David A.
Zhu, Xiaoxia
Hyatt, Brad T.
Archilla, Alfredo S.
Livingston, William J., III
Frisina, Robert D.
TI Murine intracochlear drug delivery: Reducing concentration gradients
within the cochlea
SO HEARING RESEARCH
LA English
DT Article
ID INNER-EAR; PERILYMPHATIC SCALAE; GENE-TRANSFER; GUINEA-PIG; MOUSE;
COMMUNICATION; SALICYLATE; TYMPANI; FLUIDS
AB Direct delivery of compounds to the mammalian inner ear is most commonly achieved by absorption or direct injection through the round window membrane (RWM), or infusion through a basal turn cochleostomy. These methods provide direct access to cochlear structures, but with a strong basal-to-apical concentration gradient consistent with a diffusion-driven distribution. This gradient limits the efficacy of therapeutic approaches for apical structures, and puts constraints on practical therapeutic dose ranges. A surgical approach involving both a basal turn cochleostomy and a posterior semicircular canal canalostomy provides opportunities for facilitated perfusion of cochlear structures to reduce concentration gradients. Infusion of fixed volumes of artificial perilymph (AP) and sodium salicylate were used to evaluate two surgical approaches in the mouse: cochleostomy-only (CO), or cochleostomy-plus-canalostomy (C+C). Cochlear function was evaluated via closed-system distortion product otoacoustic emissions (DPOAE) threshold level measurements from 8 to 49 kHz. AP infusion confirmed no surgical impact to auditory function, while shifts in DPOAE thresholds were measured during infusion of salicylate and AP (washout). Frequency dependent shifts were compared for the CO and C+C approaches. Computer simulations modeling diffusion, volume flow, interscala transport, and clearance mechanisms provided estimates of drug concentration as a function of cochlear position. Simulated concentration profiles were compared to frequency-dependent shifts in measured auditory responses using a cochlear tonotopic map. The impact of flow rate on frequency dependent DPOAE threshold shifts was also evaluated for both surgical approaches. Both the C+C approach and a flow rate increase were found to provide enhanced response for lower frequencies, with evidence suggesting the C+C approach reduces concentration gradients within the cochlea. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Borkholder, David A.] Rochester Inst Technol, Dept Microelect & Elect Engn, Rochester, NY 14623 USA.
[Borkholder, David A.; Zhu, Xiaoxia; Hyatt, Brad T.; Archilla, Alfredo S.; Livingston, William J., III; Frisina, Robert D.] Univ Rochester, Sch Med, Dept Otolaryngol, Rochester, NY 14642 USA.
[Borkholder, David A.; Frisina, Robert D.] Univ Rochester, Sch Med, Dept Biomed Engn, Rochester, NY 14642 USA.
[Frisina, Robert D.] Univ Rochester, Sch Med, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
[Zhu, Xiaoxia; Frisina, Robert D.] Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
RP Borkholder, DA (reprint author), Rochester Inst Technol, Dept Microelect & Elect Engn, 79 Lomb Mem Dr, Rochester, NY 14623 USA.
EM david.borkholder@rit.edu
FU NIH, National Institute on Deafness and other Communication Disorders
[K25-DC008291, P30 DC05409]; National Institute on Aging [P01 AG09524]
FX This work supported by NIH Grants from the National Institute on
Deafness and other Communication Disorders (K25-DC008291 and P30
DC05409) and the National Institute on Aging (P01 AG09524). The author's
would like to thank Dr. Alec Salt, Washington University School of
Medicine, for his help in determining appropriate input parameters for
FluidSim; Dr. Owen Brimijoin, University of Rochester Medical Center,
for developing the Matlab based DPOAE thresholding program; and Dr.
Steven Day and Oyuna Myagmar, Rochester Institute of Technology, for
assistance with the COMSOL Multiphysics modeling of cochlear flow.
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NR 23
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 2
EP 11
DI 10.1016/j.heares.2010.04.014
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900002
PM 20451593
ER
PT J
AU Walsh, KR
Pasanen, EG
McFadden, D
AF Walsh, Kyle R.
Pasanen, Edward G.
McFadden, Dennis
TI Overshoot measured physiologically and psychophysically in the same
human ears
SO HEARING RESEARCH
LA English
DT Article
ID FREQUENCY OTOACOUSTIC EMISSIONS; AUDITORY-NERVE FIBERS; SIMULTANEOUSLY
MASKED SIGNALS; INPUT-OUTPUT FUNCTIONS; NOTCHED-NOISE MASKERS;
SHORT-TERM ADAPTATION; STIMULUS-FREQUENCY; SIMULTANEOUS MASKING;
OLIVOCOCHLEAR BUNDLE; ACOUSTIC EMISSIONS
AB A nonlinear version of the stimulus-frequency otoacoustic emission (SFOAE) was measured using stimulus waveforms similar to those used for behavioral overshoot. Behaviorally, the seven listeners were as much as 11 dB worse at detecting a brief tonal signal (4.0 kHz, 10 ms in duration) when it occurred soon after the onset of a wideband masking noise (0.1-6.0 kHz; 400 ms in duration) than when it was delayed by about 200 ms, and the nonlinear SFOAE measure exhibited a similar effect. When either lowpass (0.1-3.8 kHz) or bandpass noise (3.8-4.2 kHz) was used instead of the wideband noise, the physiological and behavioral measures again were similar. When a highpass noise (4.2-6.0 kHz) was used, the physiological and behavioral measures both showed no overshoot-like effect for five of the subjects. The physiological response to the tone decayed slowly after the termination of the noise, much like the time course of resetting for behavioral overshoot. One subject exhibited no overshoot behaviorally even though his cochlear responses were like those of the other subjects. Overall, the evidence suggests that some basic characteristics of overshoot are obligatory consequences of cochlear function, as modulated by the olivocochlear efferent system. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Walsh, Kyle R.; Pasanen, Edward G.; McFadden, Dennis] Univ Texas Austin, Ctr Perceptual Syst, Dept Psychol, Austin, TX 78712 USA.
RP McFadden, D (reprint author), Univ Texas Austin, Ctr Perceptual Syst, Dept Psychol, Seay Bldg,1 Univ Stn,A8000, Austin, TX 78712 USA.
EM kylewalsh@mail.utexas.edu; pasanen@psy.utexas.edu;
mcfadden@psy.utexas.edu
FU National Institute on Deafness and other Communication Disorders (NIDCD)
[NIDCD 00153]
FX This work was supported by a research grant awarded to DM by the
National Institute on Deafness and other Communication Disorders (NIDCD
00153). Author KPW conducted this and additional research on this topic
while working on a Master's degree at The University of Texas (Walsh,
2009). Early stages of the work were reported at conferences (Walsh et
al., 2008, 2009). The work profited greatly from discussions with Drs.
C.A. Champlin, E.A. Strickland, M. Wojtczak, and N.F. Viemeister, who
also made comments on a preliminary version of this paper. Comments by
Dr. D.H. Keefe and an anonymous reviewer were extremely helpful.
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NR 71
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 22
EP 37
DI 10.1016/j.heares.2010.04.007
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900004
PM 20430072
ER
PT J
AU Zaske, R
Schweinberger, SR
Kawahara, H
AF Zaeske, Romi
Schweinberger, Stefan R.
Kawahara, Hideki
TI Voice aftereffects of adaptation to speaker identity
SO HEARING RESEARCH
LA English
DT Article
ID VISUAL-ADAPTATION; FACE RECOGNITION; FAMILIAR FACES; TEMPORAL-LOBE;
PERCEPTION; SPEECH; GENDER; SOUNDS; GAZE; REPRESENTATIONS
AB While adaptation to complex auditory stimuli has traditionally been reported for linguistic properties of speech, the present study demonstrates non-linguistic high-level aftereffects in the perception of voice identity, following adaptation to voices or faces of personally familiar speakers. In Exp. 1, prolonged exposure to speaker A's voice biased the perception of identity-ambiguous voice morphs between speakers A and B towards speaker B (and vice versa). Significantly biased voice identity perception was also observed in Exp. 2 when adaptors were videos of speakers' silently articulating faces, although effects were reduced in magnitude relative to those seen in Exp. 1. By contrast, adaptation to an unrelated speaker C elicited an intermediate proportion of speaker A identifications in both experiments. While crossmodal aftereffects on auditory identification (Exp. 2) dissipated rapidly, unimodal aftereffects (Exp. 1) were still measurable a few minutes after adaptation. These novel findings suggest contrastive coding of voice identity in long-term memory, with at least two perceptual mechanisms of voice identity adaptation: one related to auditory coding of voice characteristics, and another related to multimodal coding of familiar speaker identity. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Zaeske, Romi; Schweinberger, Stefan R.] Univ Jena, Dept Gen Psychol & Cognit Neurosci, D-07743 Jena, Germany.
[Zaeske, Romi; Schweinberger, Stefan R.] Univ Jena, DFG Res Unit Person Percept, D-07743 Jena, Germany.
[Kawahara, Hideki] Wakayama Univ, Fac Syst Engn, Wakayama 6408510, Japan.
RP Zaske, R (reprint author), Univ Jena, Dept Gen Psychol & Cognit Neurosci, Steiger 3,Haus 1, D-07743 Jena, Germany.
EM romi.zaeske@uni-jena.de
RI Hideki, Kawahara/H-6034-2011; Schweinberger, Stefan/A-1860-2009
FU Deutsche Forschungsgemeinschaft [Schw 511/10-1]
FX Supported in part by the Deutsche Forschungsgemeinschaft (grant Schw
511/10-1). The authors thank Nadine Hauthal for help in data acquisition
and David M.C. Robertson for advice on video editing.
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NR 48
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 38
EP 45
DI 10.1016/j.heares.2010.04.011
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900005
PM 20430084
ER
PT J
AU Tan, J
Clarke, M
Barrett, G
Millard, R
AF Tan, Justin
Clarke, Maria
Barrett, G.
Millard, R.
TI The p75 neurotrophin receptor protects primary auditory neurons against
acoustic trauma in mice
SO HEARING RESEARCH
LA English
DT Article
ID SPIRAL GANGLION NEURONS; INDUCED HEARING-LOSS; NERVE GROWTH-FACTOR;
SPINAL-CORD-INJURY; INNER-EAR; TARGETED MUTATION; SENSORY NEURONS;
CELL-SURVIVAL; IN-VIVO; P75(NTR)
AB In the adult rodent inner ear, p75NTR is weakly expressed in primary auditory neurons (PANS) and cochlear Schwann cells. When the organ of Corti is damaged during trauma, its expression dramatically increases. It is unclear what role p75NTR plays under these conditions. Characterisation of p75NTR mutant mice reveals that altering genetic backgrounds can differentially affect the survival of PANs in mutant mice. To conclusively elucidate the physiological role of p75NTR in the cochlea, we challenged wild type (p75NTR +/+) and mutant (p75NTR -/-) mice with an acoustic trauma at 130 dB SPL, 10 kHz for 2 h. This produces a permanent auditory threshold shift >40 dB SPL, damages the organ of Corti and causes secondary degeneration of PANs. After exposure, mice were maintained for 3-9 weeks. Interestingly, survival of PANs in p75NTR -/- mice was significantly compromised in all time-points when compared to wild type mice: 15% reduction after 3 weeks (n = 6), 32% reduction after 6 weeks (n = 6) and 26% reduction after 9 weeks (n = 6-8). Therefore, our data do not support a role of p75NTR as a death inducer in PANs but show its crucial role in protecting PANs. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Tan, Justin] Bion Ear Inst, Melbourne, Vic 3002, Australia.
[Tan, Justin; Clarke, Maria; Millard, R.] Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
[Barrett, G.] Univ Melbourne, Dept Physiol, Parkville, Vic 3010, Australia.
RP Tan, J (reprint author), Bion Ear Inst, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM jtan@bionicear.org
FU Garnett Passe and Rodney Williams Memorial Foundation; Victorian
Government
FX This work is mainly supported by the Garnett Passe and Rodney Williams
Memorial Foundation with other contributions from the Royal Victorian
Eye and Ear Hospital and the Percy Baxter Charitable Trust (all awarded
to JT). We would like to thank Dr. Simon Murray from the Howard Florey
Institute for helping us obtain the p75NTR mice in B6 genetic background
and Dr. James Fallon from the Bionic Ear Institute for assistance with
ABRs. The Bionic Ear Institute acknowledges the support it received from
the Victorian Government through its Operational Infrastructure Support
Program.
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NR 42
TC 5
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 46
EP 59
DI 10.1016/j.heares.2010.04.013
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900006
PM 20466052
ER
PT J
AU Krishnan, A
Bidelman, GM
Gandour, JT
AF Krishnan, Ananthanarayan
Bidelman, Gavin M.
Gandour, Jackson T.
TI Neural representation of pitch salience in the human brainstem revealed
by psychophysical and electrophysiological indices
SO HEARING RESEARCH
LA English
DT Article
ID ITERATED RIPPLED NOISE; FREQUENCY-FOLLOWING RESPONSES; HUMAN AUDITORY
BRAIN; VENTRAL COCHLEAR NUCLEUS; COMPLEX TONES; TEMPORAL REPRESENTATION;
UNRESOLVED HARMONICS; HESCHLS GYRUS; SINGLE UNITS; STRENGTH
AB Acoustically, pitch is related to the temporal regularity or periodicity of a sound. Perceptual and electrophysiologic studies have revealed that pitch salience grows systematically with increasing stimulus periodicity. The aim of this study is to show that information relevant to pitch salience is already encoded in the phase-locked neural activity of brainstem neurons in order to demonstrate that the neural manifestation of pitch salience emerges well before cortical involvement. Brainstem frequency following responses (FFRs) were recorded from participants in response to linguistic tones, which varied only in their degree of pitch salience. Neural pitch strength was computed from FFRs using autocorrelation algorithms. In addition, behavioral frequency difference limens (F0 DLs) were measured from each participant to obtain a perceptual estimate related to pitch salience. Brainstem neural pitch strength increased systematically with increasing temporal regularity in stimulus periodicity, indicating more robust encoding for salient pitch. F0 DLs decreased with increasing stimulus periodicity revealing better pitch change detection for more salient stimuli. FFR neural pitch strength and behavioral F0 DLs were negatively correlated suggesting that subcortical processing can, in part, predict an individual's behavioral judgments of pitch salience. These data imply that changes to the acoustic periodicity of a stimulus directly influence brainstem encoding and the corresponding behavioral responses to pitch. We infer that information related to pitch salience may emerge early along the auditory pathway and is likely rooted in pre-attentive, sensory-level processing. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Krishnan, Ananthanarayan; Bidelman, Gavin M.; Gandour, Jackson T.] Purdue Univ, Dept Speech Language Hearing Sci, W Lafayette, IN 47907 USA.
RP Krishnan, A (reprint author), Purdue Univ, Dept Speech Language Hearing Sci, 1353 Heavilon Hall,500 Oval Dr, W Lafayette, IN 47907 USA.
EM rkrish@purdue.edu; gbidelma@purdue.edu; gandour@purdue.edu
FU NIH [R01 DC008549, T32 DC 00030]
FX Research supported by NIH R01 DC008549 (A.K.) and T32 DC 00030 NIDCD
predoctoral traineeship (G.B.). Thanks to Jin Xia for her assistance
with statistical analysis (Department of Statistics) and Dr. Chris Plack
(University of Manchester) for supplying the MATLAB scripts for the
behavioral task. We would also like to thank the anonymous reviewers for
their insightful comments to improve this manuscript. Reprint requests
should be addressed to Ananthanarayan Krishnan, Department of Speech
Language Hearing Sciences, Purdue University, West Lafayette, IN
47907-2038, USA, or via email: rkrish@purdue.edu.
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NR 52
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 60
EP 66
DI 10.1016/j.heares.2010.04.016
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900007
PM 20457239
ER
PT J
AU Dingle, RN
Hall, SE
Phillips, DP
AF Dingle, Rachel N.
Hall, Susan E.
Phillips, Dennis P.
TI A midline azimuthal channel in human spatial hearing
SO HEARING RESEARCH
LA English
DT Article
ID PRIMARY AUDITORY-CORTEX; INTERAURAL TIME DIFFERENCES; CAT
CEREBRAL-CORTEX; DEFINED AREA AI; SOUND-LOCALIZATION; SINGLE NEURONS;
SENSITIVITY; FREQUENCY; RESPONSES; LOCATION
AB Neurophysiological and psychophysical evidence has driven the formulation of a hemifield model of mammalian sound localization in which the perceived location of a stimulus is based on the relative activity of two hemifield-tuned azimuthal channels that are broadly responsive to contralateral auditory space and have overlapping medial borders. However, neurophysiological work in mammals has consistently found neurons selective for sound sources at the midline, which may indicate the existence of a third, 'midline', perceptual channel. In three experiments, the existence of three (left, right, midline) perceptual channels for azimuth in man was examined using auditory selective adaptation paradigms. If no midline channel exists, exposure to highly lateralized, symmetrical adaptator frequencies should not result in a shift in the perceived intracranial location of subsequent test tones away from the adaptors because the relative activation of the two hemifield channels will remain the same. Rather, our results indicate a shift in perceived test tones towards the azimuthal midline. This result can best be explained by a perceptual/neural channel tuned to sounds located along the midline. The present study gives the first psychophysical evidence of a midline channel serving human auditory localization, adding to the earlier evidence on the same point from animal neurophysiological studies. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Dingle, Rachel N.; Hall, Susan E.; Phillips, Dennis P.] Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
[Phillips, Dennis P.] Dalhousie Univ, Dept Surg, Halifax, NS B3H 4J1, Canada.
RP Dingle, RN (reprint author), Dalhousie Univ, Dept Psychol, Hearing Res Lab, 1355 Oxford St, Halifax, NS B3H 4J1, Canada.
EM rdingle@dal.ca
RI Phillips, Dennis/A-6496-2011
FU NSERC of Canada; Killam Trust
FX This research was supported by grants from NSERC of Canada and the
Killam Trust to DPP. RND was supported by a post-graduate scholarship
from NSERC. Thanks also to Dr. M. V. Trotter for her help finalizing the
figures, and to two anonymous reviewers for helpful comments on a
previous version of this manuscript.
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NR 34
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 67
EP 74
DI 10.1016/j.heares.2010.04.017
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900008
PM 20457238
ER
PT J
AU Schoffelen, RLM
Segenhout, JM
van Dijk, P
AF Schoffelen, Richard L. M.
Segenhout, Johannes M.
van Dijk, Pim
TI Input-output characteristics of the tectorial membrane in the frog
basilar papilla
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY-NERVE FIBERS; HAIR-CELLS; RANA-CATESBEIANA; BULLFROG; EAR;
FREQUENCY; RESPONSES
AB The basilar papilla (BP) in the frog inner ear is a relatively simple auditory receptor. Its hair cells are embedded in a stiff support structure, with the stereovilli connecting to a flexible tectorial membrane (TM). Acoustic energy passing the papilla presumably causes displacement of the TM, which in turn deflects the stereovilli and stimulates the hair cells. In this paper we present optical measurements of the mechanical response of the TM to various stimulus levels. Results were obtained from 3 specimens (4 ears). The phase of the displaced area of the TM was constant across stimulus levels. Phase differences between the orthogonal spatial motion components were either close to 0 degrees or 180 degrees. These findings were consistent with a TM motion along the epithelium surface. The TM response was linear for stimulus levels up to -30 dB (re. 1 mu m) at the operculum. This amplitude was estimated to exceed that at which neural responses saturate. Apparently, saturation of the neural response in the frog inner ear is not based on saturation of the mechanical response of the tectorial membrane. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Schoffelen, Richard L. M.; Segenhout, Johannes M.; van Dijk, Pim] Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, NL-9700 RB Groningen, Netherlands.
[Schoffelen, Richard L. M.; Segenhout, Johannes M.; van Dijk, Pim] Univ Groningen, Sch Behav & Cognit Neurosci, Fac Med Sci, NL-9700 AB Groningen, Netherlands.
RP van Dijk, P (reprint author), Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, POB 30001, NL-9700 RB Groningen, Netherlands.
EM p.van.dijk@med.umcg.nl
RI Van Dijk, Pim/E-8019-2010
OI Van Dijk, Pim/0000-0002-8023-7571
FU Heinsius Houbolt Foundation; Netherlands Organisation for Scientific
Research
FX This study was supported by the Heinsius Houbolt Foundation and the
Netherlands Organisation for Scientific Research.
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NR 22
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 75
EP 84
DI 10.1016/j.heares.2010.04.018
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900009
PM 20457241
ER
PT J
AU Johnson, KR
Yu, HP
Ding, DL
Jiang, HY
Gagnon, LH
Salvi, RJ
AF Johnson, Kenneth R.
Yu, Heping
Ding, Dalian
Jiang, Haiyan
Gagnon, Leona H.
Salvi, Richard J.
TI Separate and combined effects of Sod1 and Cdh23 mutations on age-related
hearing loss and cochlear pathology in C57BL/6J mice
SO HEARING RESEARCH
LA English
DT Article
ID HAIR CELL LOSS; CU/ZN-SUPEROXIDE-DISMUTASE; INNER-EAR; OXIDATIVE STRESS;
INBRED STRAINS; WALTZER MICE; MOUSE; SUSCEPTIBILITY; CADHERIN-23;
DEAFNESS
AB Both the ahl allele of Cdh23 and the null mutation of Sod1 have been shown to contribute to age-related hearing loss (AHL) in mice, but mixed strain backgrounds have confounded analyses of their individual and combined effects. To test for the effects of Sod1 deficiency independently from those of Cdh23(ahl), we produced mice with four digenic genotypes: Sod1(+/+) Cdh23(ahl/ahl), Sod1(+/+) Cdh23(+/+), Sod1(-/-) Cdh23(ahl/ahl), and Sod1(-/-) Cdh23(+/+), all on a uniform C57BL/6J strain background. We assessed hearing loss by ABR threshold measurements and evaluated cochlear pathologies in age-matched mice of each digenic combination. ABR analysis showed that Sod1(+/+) Cdh23(+/+) mice retain normal hearing up to 15 months of age and that hearing loss of Sod1(+/+) Cdh23(ahl/ahl) mice is more age and frequency dependent than that of Sod1(-/-) Cdh23(+/+) mice. ABR results also showed that mice with both gene mutations (Sod1(-/-) Cdh23(ahl/ahl)) exhibit the earliest onset and most severe hearing loss, greater than predicted for strictly additive effects. Histological analysis of cochleas showed that hair cell lesions are most severe in Sod1(-/-) Cdh23(ahl/ahl) mice followed closely by Sod1(+/+) cdh23(ahl/ahl) mice and much smaller in Sod1(-/-) Cdh23(+/+) and Sod1(+/+) Cdh23(+/+) mice. Despite extensive damage to cochlear hair cells, vestibular hair cells appeared remarkably normal in all strains. Although both Sod1(-/-) and Cdh23(ahl/ahl) genotypes had strong effects on hearing loss, the Cdh23(ahl/ahl) genotype was primarily responsible for the increase in hair cell loss, suggesting that the two mutations have different underlying mechanisms of pathology. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Johnson, Kenneth R.; Yu, Heping; Gagnon, Leona H.] Jackson Lab, Bar Harbor, ME 04609 USA.
[Ding, Dalian; Jiang, Haiyan; Salvi, Richard J.] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Johnson, KR (reprint author), Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
EM ken.johnson@jax.org
FU National Institutes of Health (NIH), National Institute on Deafness and
Other Communication Disorders [DC005827, DC006630]; NIH National Cancer
Institute [CA34196]
FX We thank Patsy Nishina and David Bergstrom for critical review of this
manuscript. We also thank Sandra Gray for her skilled husbandry and
management of inbred strain mice. This research was supported by R01
grants DC005827 (KRJ) and DC006630 (RJS) from the National Institutes of
Health (NIH), National Institute on Deafness and Other Communication
Disorders. The Jackson Laboratory institutional shared services are
supported by NIH National Cancer Institute support grant CA34196.
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NR 46
TC 9
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 85
EP 92
DI 10.1016/j.heares.2010.05.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900010
PM 20470874
ER
PT J
AU Goldwyn, JH
Bierer, SM
Bierer, JA
AF Goldwyn, Joshua H.
Bierer, Steven M.
Bierer, Julie Arenberg
TI Modeling the electrode-neuron interface of cochlear implants: Effects of
neural survival, electrode placement, and the partial tripolar
configuration
SO HEARING RESEARCH
LA English
DT Article
ID INTRACOCHLEAR POSITION; SPEECH RECOGNITION; ELECTRICAL-FIELD; INSERTION
TRAUMA; LOUDNESS GROWTH; TEMPORAL BONE; TUNING CURVES; STIMULATION;
PERCEPTION; MONOPOLAR
AB The partial tripolar electrode configuration is a relatively novel stimulation strategy that can generate more spatially focused electric fields than the commonly used monopolar configuration. Focused stimulation strategies should improve spectral resolution in cochlear implant users, but may also be more sensitive to local irregularities in the electrode neuron interface. In this study, we develop a practical computer model of cochlear implant stimulation that can simulate neural activation in a simplified cochlear geometry and we relate the resulting patterns of neural activity to basic psychophysical measures. We examine how two types of local irregularities in the electrode neuron interface, variations in spiral ganglion nerve density and electrode position within the scala tympani, affect the simulated neural activation patterns and how these patterns change with electrode configuration. The model shows that higher partial tripolar fractions activate more spatially restricted populations of neurons at all current levels and require higher current levels to excite a given number of neurons. We find that threshold levels are more sensitive at high partial tripolar fractions to both types of irregularities, but these effects are not independent. In particular, at close electrode neuron distances, activation is typically more spatially localized which leads to a greater influence of neural dead regions. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Bierer, Julie Arenberg] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
[Goldwyn, Joshua H.] Univ Washington, Dept Appl Math, Seattle, WA 98195 USA.
[Bierer, Steven M.] Univ Washington, Dept Otolaryngol, Seattle, WA 98195 USA.
[Bierer, Julie Arenberg] Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
RP Bierer, JA (reprint author), Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
EM jgoldwyn@uw.edu; sbierer@uw.edu; jbierer@uw.edu
FU National Science Foundation; National Institute on Deafness and Other
Communication Disorders [F31 DC010306, R03 DC008883]; University of
Washington [3652]
FX The authors thank J. Nathan Kutz and two reviewers for providing
comments on previous versions of this manuscript. This research has been
supported by a National Science Foundation VIGRE Fellowship (JHG),
National Institute on Deafness and Other Communication Disorders (F31
DC010306 - JHG) and (R03 DC008883 - JAB), and by the University of
Washington Royalty Research Fund (#3652 - JAB).
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NR 54
TC 22
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 93
EP 104
DI 10.1016/j.heares.2010.05.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900011
PM 20580801
ER
PT J
AU Kopelovich, JC
Eisen, MD
Franck, KH
AF Kopelovich, Jonathan C.
Eisen, Marc D.
Franck, Kevin H.
TI Frequency and electrode discrimination in children with cochlear
implants
SO HEARING RESEARCH
LA English
DT Article
ID SPEECH-PERCEPTION; YOUNG-CHILDREN; RECOGNITION; LEVEL
AB The objective of this study was to develop reliable pediatric psychophysical methodologies in order to address the limits of frequency and electrode discrimination in children with cochlear implants. Discrimination was measured with a two-alternative, adaptive, forced choice design using a video game graphical user interface. Implanted children were compared to normal-hearing children in the same age ranges. Twenty-nine implanted children and 68 children with normal-hearing performed frequency discrimination studies at varying frequencies. Electrode discrimination was assessed in thirty-four implanted children at varying electrode locations and stimulation intensities. Older children had better frequency discrimination than younger children, both for implanted and hearing subjects. Implanted children had worse frequency discrimination overall and exhibited learning effects at older ages than hearing children. Frequency discrimination Weber fractions were smallest in low frequencies. Electrode discrimination improved with stimulus intensity level for older but not younger children at all electrode locations. These results support the premise that developmental changes in signal processing contribute to discrimination of simple acoustic stimuli. For implanted children, auditory discrimination improved at lower frequencies and with electrodes at higher intensity. These findings imply that spatial separation may not be the key determinant in creating discriminable electrical stimuli for this population. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Kopelovich, Jonathan C.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
[Eisen, Marc D.] Univ Connecticut, Hartford, CT 06112 USA.
[Franck, Kevin H.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Franck, Kevin H.] Univ Penn, Philadelphia, PA 19104 USA.
RP Kopelovich, JC (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA.
EM jokopelo@gmail.com
FU Deafness Research Foundation; Emil Capita Foundation
FX Sources of support: Deafness Research Foundation, Emil Capita
Foundation.
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NR 26
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 105
EP 113
DI 10.1016/j.heares.2010.05.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900012
PM 20553829
ER
PT J
AU Al-Mana, D
Ceranic, B
Djahanbakhch, O
Luxon, LM
AF Al-Mana, Deena
Ceranic, Borka
Djahanbakhch, Ovrang
Luxon, Linda M.
TI Alteration in auditory function during the ovarian cycle
SO HEARING RESEARCH
LA English
DT Article
ID SPONTANEOUS OTOACOUSTIC EMISSIONS; BRAIN-STEM RESPONSE; MENSTRUAL-CYCLE;
ESTROGEN-RECEPTORS; ORAL-CONTRACEPTIVES; HEARING-LOSS; INNER-EAR;
FREQUENCY; HORMONES; WOMEN
AB This study investigates whether physiological variations in ovarian hormones during the ovarian cycle (OC) are associated with changes in auditory function.
Sixteen women with normal hearing underwent auditory tests and simultaneous measurements of the hormone levels four times during OC. The auditory tests included recording of otoacoustic emissions (OAEs), the medial olivocochlear (MOC) suppression and auditory brainstem responses (ABRs). The OC was defined by oestradiol and progesterone serum levels and menstrual cycle dating.
A significant spontaneous OAE frequency shift [F(3,114.6) = 15.8, p < 0.001], with the greatest shift in the late follicular phase (highest oestrogen levels), was observed. Transient evoked OAE levels showed a consistent tendency in an increase in all frequency bands in the late follicular/early luteal stage and a decrease in the late follicular stage: TEOAE inter-session comparison indicated very small statistical differences. The MOC suppression changed significantly during OC [F(3.33.8) = 3.2, p = 0.036], with significant inter-session difference, lower in session 2 than in session 1 (p = 0.019) and lower in session 4 than in session 1 (p = 0.007). The ABR wave V absolute latency changed significantly during OC [F(3,33) = 3.3, p = 0.03], longer in the late follicular phase. There was also a significant positive correlation of TEOAEs and ABR (wave V latency and III-V interval) and significant negative correlation of MOC suppression with oestradiol levels in the follicular phase.
The results of this study reflect very small changes in auditory function during OC, and they are suggestive of an increased hearing sensitivity around the time of ovulation. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Ceranic, Borka] Univ London St Georges Hosp, Dept Audiol, London SW17 0QT, England.
[Al-Mana, Deena; Luxon, Linda M.] Natl Hosp Neurol & Neurosurg, Dept Neurootol, London WC1N 3BG, England.
[Djahanbakhch, Ovrang] Newham Univ Hosp, Acad Dept Obstet & Gynaecol, London E13 8SL, England.
[Djahanbakhch, Ovrang] St Bartholomews Hosp, Reprod Med Unit, London EC1A 7BE, England.
[Al-Mana, Deena; Luxon, Linda M.] UCL, Ear Inst, London WC1X 8EE, England.
[Al-Mana, Deena] King Saud Univ, Coll Med, Acad Dept Otolaryngol & Head & Neck Surg, Riyadh 1141, Saudi Arabia.
RP Ceranic, B (reprint author), Univ London St Georges Hosp, Dept Audiol, Lanesborough Wing,Blackshaw Rd, London SW17 0QT, England.
EM borka.ceranic@stgeorges.nhs.uk
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NR 70
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 114
EP 122
DI 10.1016/j.heares.2010.05.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900013
PM 20685243
ER
PT J
AU Rao, A
Zhang, Y
Miller, S
AF Rao, Aparna
Zhang, Yang
Miller, Sharon
TI Selective listening of concurrent auditory stimuli: An event-related
potential study
SO HEARING RESEARCH
LA English
DT Article
ID SPECTROTEMPORAL RECEPTIVE-FIELDS; EVOKED-POTENTIALS; SPEECH-PERCEPTION;
BRAIN POTENTIALS; ATTENTION; CORTEX; MODULATION; ERP; REORGANIZATION;
INFORMATION
AB This study employed behavioral and electrophysiological measures to examine selective listening of concurrent auditory stimuli. Stimuli consisted of four compound sounds, each created by mixing a pure tone with filtered noise bands at a signal-to-noise ratio of +15 dB. The pure tones and filtered noise bands each contained two levels of pitch. Two separate conditions were created; the background stimuli varied randomly or were held constant. In separate blocks, participants were asked to judge the pitch of tones or the pitch of filtered noise in the compound stimuli. Behavioral data consistently showed lower sensitivity and longer response times for classification of filtered noise when compared with classification of tones. However, differential effects were observed in the peak components of auditory event-related potentials (ERPs). Relative to tone classification, the P1 and N1 amplitudes were enhanced during the more difficult noise classification task in both test conditions, but the peak latencies were shorter for P1 and longer for N1 during noise classification. Moreover, a significant interaction between condition and task was seen for the P2. The results suggest that the essential ERP components for the same compound auditory stimuli are modulated by listeners' focus on specific aspects of information in the stimuli. Published by Elsevier B.V.
C1 [Rao, Aparna; Zhang, Yang; Miller, Sharon] Univ Minnesota, Dept Speech Language Hearing Sci, Minneapolis, MN 55455 USA.
[Zhang, Yang] Univ Minnesota, Ctr Neurobehav Dev, Minneapolis, MN 55455 USA.
RP Rao, A (reprint author), Univ Minnesota, Dept Speech Language Hearing Sci, 115 Shevlin Hall,164 Pillsbury Dr SE, Minneapolis, MN 55455 USA.
EM raoxx098@umn.edu; zhang470@umn.edu; mill1979@umn.edu
FU American Speech-Language-Hearing Foundation; University of Minnesota;
CLA Associate
FX We would like to thank Liz Tusler, Tess Koerner, Asher Miller, Kayla
Kelsey, Jason Sumontha and Dr. Edward Carney for their assistance in
data collection. Thanks to Dr. Robert D. Melara and two anonymous
reviewers for providing invaluable suggestions to improve this
manuscript. Rao gratefully acknowledges financial support from the
American Speech-Language-Hearing Foundation and the University of
Minnesota. Zhang acknowledges lab startup funds from the University of
Minnesota, Brain Imaging Research Awards (2008 and 2009) from the
College of Liberal Arts, and support from CLA Associate Dean, Dr. Jo-Ida
Hansen.
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NR 54
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 123
EP 132
DI 10.1016/j.heares.2010.05.013
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900014
PM 20595021
ER
PT J
AU Dugue, P
Le Bouquin-Jeannes, R
Edeline, JM
Faucon, G
AF Dugue, Pierre
Le Bouquin-Jeannes, Regine
Edeline, Jean-Marc
Faucon, Gerard
TI A physiologically based model for temporal envelope encoding in human
primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
ID DORSAL COCHLEAR NUCLEUS; TONE-EVOKED OSCILLATIONS; BROAD-BAND NOISE;
AMPLITUDE-MODULATION; INFERIOR COLLICULUS; FREQUENCY-SELECTIVITY;
RECURRENT NETWORKS; RETICULAR NUCLEUS; COMPUTER-MODEL; RESPONSES
AB Communication sounds exhibit temporal envelope fluctuations in the low frequency range (<70 Hz) and human speech has prominent 2-16 Hz modulations with a maximum at 3-4 Hz. Here, we propose a new phenomenological model of the human auditory pathway (from cochlea to primary auditory cortex) to simulate responses to amplitude-modulated white noise. To validate the model, performance was estimated by quantifying temporal modulation transfer functions (TMTFs). Previous models considered either the lower stages of the auditory system (up to the inferior colliculus) or only the thalamocortical loop. The present model, divided in two stages, is based on anatomical and physiological findings and includes the entire auditory pathway. The first stage, from the outer ear to the colliculus, incorporates inhibitory interneurons in the cochlear nucleus to increase performance at high stimuli levels. The second stage takes into account the anatomical connections of the thalamocortical system and includes the fast and slow excitatory and inhibitory currents. After optimizing the parameters of the model to reproduce the diversity of TMTFs obtained from human subjects, a patient-specific model was derived and the parameters were optimized to effectively reproduce both spontaneous activity and the oscillatory part of the evoked response. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Dugue, Pierre; Le Bouquin-Jeannes, Regine; Faucon, Gerard] INSERM, U642, F-35000 Rennes, France.
[Dugue, Pierre; Le Bouquin-Jeannes, Regine; Faucon, Gerard] Univ Rennes 1, LTSI, F-35000 Rennes, France.
[Edeline, Jean-Marc] CNPS, CNRS, UMR 8195, F-91405 Orsay, France.
[Edeline, Jean-Marc] Univ Paris 11, F-91405 Orsay, France.
RP Le Bouquin-Jeannes, R (reprint author), Univ Rennes 1, Lab Traitement Signal & Image, Campus Beaulieu, F-35042 Rennes, France.
EM regine.le-bouquin-jeannes@univ-rennes1.fr
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NR 81
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 133
EP 144
DI 10.1016/j.heares.2010.05.014
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900015
PM 20685388
ER
PT J
AU Zheng, YW
Stiles, L
Hamilton, E
Smith, PF
Darlington, CL
AF Zheng, Yiwen
Stiles, Lucy
Hamilton, Emma
Smith, Paul F.
Darlington, Cynthia L.
TI The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2
and CP55,940, on salicylate-induced tinnitus in rats
SO HEARING RESEARCH
LA English
DT Article
ID ANIMAL-MODEL; ENDOCANNABINOID SYSTEM; BRAIN-STEM; BEHAVIORAL PARADIGM;
COCHLEAR NUCLEUS; DOWN-REGULATION; LOCALIZATION; OTOTOXICITY;
HIPPOCAMPUS; ACTIVATION
AB Previous studies in animals and humans have shown that, in some cases at least, anti-epileptic drugs can reduce the severity of tinnitus. Given that cannabinoid receptor agonists have been shown to exert anti-epileptic effects in some circumstances, we investigated whether two synthetic CB(1)/CB(2) receptor agonists, WIN55,212-2, and CP55,940, could inhibit the behavioural manifestations of salicylate-induced tinnitus in rats in a conditioned suppression task. We found that neither WIN55,212-2 (3.0 mg/kg s.c) nor CP55,940 (0.1 or 0.3 mg/kg s.c), significantly reduced conditioned behaviour associated with tinnitus. However, both 3 mg/kg WIN55,212-2 and 0.3 mg/kg CP55,940 did significantly increase tinnitus-related behaviour compared to the vehicle control groups. These results suggest that cannabinoid receptor agonists may not be useful in the treatment of salicylate-induced tinnitus and that at certain doses, they could actually exacerbate the condition. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Zheng, Yiwen; Stiles, Lucy; Hamilton, Emma; Smith, Paul F.; Darlington, Cynthia L.] Univ Otago, Sch Med, Sch Med Sci, Dept Pharmacol & Toxicol, Dunedin, New Zealand.
RP Zheng, YW (reprint author), Univ Otago, Sch Med, Sch Med Sci, Dept Pharmacol & Toxicol, POB 913, Dunedin, New Zealand.
EM yiwen.zheng@stonebow.otago.ac.nz
FU Garnett Passe Rodney Williams Foundation of Australia; Jean Cathie
Estate; National Deafness Foundation of New Zealand; University of Otago
Division of Health Sciences
FX This research was supported by grants from the Garnett Passe Rodney
Williams Foundation of Australia, the Jean Cathie Estate, the National
Deafness Foundation of New Zealand and a University of Otago Division of
Health Sciences grant. We thank Dr. Chisako Masumura for her
contributions to preliminary studies used in designing these
experiments.
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NR 45
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 145
EP 150
DI 10.1016/j.heares.2010.05.015
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900016
PM 20630477
ER
PT J
AU Pienkowski, M
Eggermont, JJ
AF Pienkowski, Martin
Eggermont, Jos J.
TI Passive exposure of adult cats to moderate-level tone pip ensembles
differentially decreases AI and AII responsiveness in the exposure
frequency range
SO HEARING RESEARCH
LA English
DT Article
ID PRIMARY AUDITORY-CORTEX; ACOUSTIC ENVIRONMENT; CORTICAL FIELDS; NOISE
TRAUMA; ORGANIZATION; REPRESENTATION; PLASTICITY; CONNECTIONS;
HABITUATION; INTENSITY
AB Passive exposure of adult animals to a random ensemble of tone pips band limited between 4 and 20 kHz has been shown to suppress neural activity in primary auditory cortex (AI) to sounds in the exposure frequency range. In the long-term (>3 months), the suppressed neurons can be reactivated by frequencies above and below the exposure range, i.e., tonotopic map reorganization occurs. The suppression can be at least partially reversed after a long period of quiet recovery, as the moderate-level exposure does not impair peripheral hearing. Here we exposed adult cats, for 7-13 weeks without interruption, to two different moderate-level tone pip ensembles, in separate experiments. One exposure stimulus consisted of an octave-wide 2-4 kHz band, which overlaps substantially with the cat vocalization range; the other consisted of a pair of third-octave bands centered at 4 and 16 kHz. We again report a decrease in AI responsiveness in the exposure frequency range, irrespective of the exposure stimulus bandwidth or center frequency, and a slow, partial recovery over a 12-week post-exposure window. In contrast to our previous studies, the suppression in both of the present experiments extended well beyond the exposure frequency range. In particular, following the 4 and 16 kHz experimental acoustic environment, AI activity was strongly suppressed not only in response to frequencies close to the two exposure bands, but also in response to frequencies between the bands, i.e., the results resembled those to a single broadband stimulus spanning the 3-18 kHz range. On the other hand, responses in secondary auditory cortex (All) were suppressed predominantly around 4 and 16 kHz, with little or no suppression in between. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Eggermont, Jos J.] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada.
Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Physiol & Pharmacol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM eggermon@ucalgary.ca
FU Alberta Heritage Foundation for Medical Research; Natural Sciences and
Engineering Research Council; Campbell McLaurin Chair of Hearing
Deficiencies
FX This work was supported by the Alberta Heritage Foundation for Medical
Research, by the Natural Sciences and Engineering Research Council, and
by the Campbell McLaurin Chair of Hearing Deficiencies. Greg Shaw
provided programming support.
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NR 35
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 151
EP 162
DI 10.1016/j.heares.2010.05.016
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900017
PM 20630476
ER
PT J
AU Ramunno-Johnson, D
Strimbu, CE
Kao, A
Hemsing, LF
Bozovic, D
AF Ramunno-Johnson, D.
Strimbu, C. E.
Kao, A.
Hemsing, L. Fredrickson
Bozovic, D.
TI Effects of the somatic ion channels upon spontaneous mechanical
oscillations in hair bundles of the inner ear
SO HEARING RESEARCH
LA English
DT Article
ID CELL TRANSDUCTION CHANNELS; MECHANOELECTRICAL TRANSDUCTION; BULLFROGS
SACCULUS; RANA-CATESBEIANA; FAST ADAPTATION; ACTIVE PROCESS; BULL-FROG;
CALCIUM; MECHANOTRANSDUCTION; AMPLIFICATION
AB Decoupled hair bundles of the bullfrog (Litho bates catesbeianus) sacculus exhibit spontaneous oscillations in vitro. We examine the effect of the somatic electrical circuit upon active hair bundle motility. We found that innate bundle movements exhibit a complex profile with multiple periodicities. Inhibition of somatic ion channels using targeted neurotoxins and modified physiological solutions strongly affects the bundles' mechanical behavior, modifying the amplitude and the temporal characteristics of the oscillation profile. Published by Elsevier B.V.
C1 [Ramunno-Johnson, D.; Strimbu, C. E.; Kao, A.; Hemsing, L. Fredrickson; Bozovic, D.] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA.
RP Bozovic, D (reprint author), Univ Calif Los Angeles, Dept Phys & Astron, 475 Portola Plaza, Los Angeles, CA 90095 USA.
EM bozovic@physics.ucla.edu
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NR 58
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 163
EP 171
DI 10.1016/j.heares.2010.05.017
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900018
PM 20566385
ER
PT J
AU Lu, WF
Zhou, D
Freeman, JJ
Thalmann, I
Ornitz, DM
Thalmann, R
AF Lu, Wenfu
Zhou, Dan
Freeman, John J.
Thalmann, Isolde
Ornitz, David M.
Thalmann, Ruediger
TI In vitro effects of recombinant otoconin 90 upon calcite crystal growth.
Significance of tertiary structure
SO HEARING RESEARCH
LA English
DT Article
ID PROTEIN SECONDARY STRUCTURE; GOOSE EGGSHELL MATRIX; ACID-RICH PROTEIN;
INNER-EAR; CIRCULAR-DICHROISM; PHOSPHOLIPASE A(2); ENDOLYMPHATIC SAC;
ORGANIC MATRIX; MAJOR PROTEIN; BIOMINERALIZATION
AB Otoconia are biomineral particles of microscopic size essential for perception of gravity and maintenance of balance. Millions of older Americans are affected in their mobility, quality of life and in their health by progressive demineralization of otoconia. Currently, no effective means to prevent or counteract this process are available. Because of prohibitive anatomical and biological constraints, otoconial research is lagging far behind other systems such as bone and teeth. We have overcome these obstacles by generating otoconial matrix proteins by recombinant techniques. In the present study, we evaluated the effects of recombinant Otoconin 90 (OC90), the principal soluble matrix protein upon calcite crystal growth patterns in vitro. Our findings highlight multiple effects, including facilitation of nucleation, and inhibition of crystal growth in a concentration-dependent manner. Moreover, OC90 induces morphologic changes characteristic of native otoconia.
OC90 is considerably less acidic than the prototypical invertebrate CaCO(3) - associated protein, but is nevertheless an effective modulator of calcite crystal growth. Based on homology modeling of the sPLA2-like domains of OC90, we propose that the lower density of acidic residues of the primary sequence is compensated by formation of major anionic surface clusters upon folding into tertiary conformation. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Lu, Wenfu; Thalmann, Isolde; Thalmann, Ruediger] Washington Univ, Sch Med St Louis, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
[Zhou, Dan] Univ Missouri, Ctr Nanosci, St Louis, MO 63121 USA.
[Freeman, John J.] Washington Univ, Dept Earth & Planetary Sci, St Louis, MO 63130 USA.
[Ornitz, David M.] Washington Univ, Sch Med St Louis, Dept Dev Biol, St Louis, MO 63110 USA.
RP Thalmann, R (reprint author), Washington Univ, Sch Med St Louis, Dept Otolaryngol Head & Neck Surg, Campus Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA.
EM luwenfu@gmail.com; zhouda@umsl.edu; johnjfreeman@wustl.edu;
thalmann_i@ent.wustl.edu; dornitz@wustl.edu; thalmannr@ent.wustl.edu
FU National Institute on Deafness and other Communication Disorders, NIH
[DC 009320, DC02236]
FX We thank Dr. Lijuan Zhang for prediction of the chondroitin sulfate
site; Dr. Jianbo Wang for providing the mammalian expression vector
pcDNA3.1 (+) neomycin; Dr. Carl Frieden for valuable discussion on CD;
Dr. Thomas Brett for technical assistance with CD and DLS, and
discussion of DLS data. This study was supported by DC 009320 (RT) and
DC02236 (DMO) from the National Institute on Deafness and other
Communication Disorders, NIH.
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NR 72
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 172
EP 183
DI 10.1016/j.heares.2010.05.019
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900019
PM 20595020
ER
PT J
AU Muller, M
Hoidis, S
Smolders, JWT
AF Mueller, Marcus
Hoidis, Silvi
Smolders, Jean W. T.
TI A physiological frequency-position map of the chinchilla cochlea
SO HEARING RESEARCH
LA English
DT Article
ID BASILAR-MEMBRANE VIBRATIONS; AUDITORY-NERVE FIBERS; GUINEA-PIG; ACOUSTIC
TRAUMA; TUNING CURVES; RAT COCHLEA; CELL LOSS; THRESHOLD;
REPRESENTATION; MECHANICS
AB Accumulating evidence indicates that mammalian cochlear frequency-position maps (location of maximum vibration of the basilar membrane as a function of frequency) depend on the physiological condition of the inner ear. Cochlear damage desensitizes the ear, after the damage the original location of maximum vibration is tuned to a lower sound frequency. This suggests that frequency-position maps, derived from such desensitized ears, are shifted to lower frequencies, corresponding to a shift of the basilar membrane vibration pattern towards the base for a given stimulus frequency. To test this hypothesis, we re-mapped the cochlear frequency-position map in the chinchilla. We collected frequency-position data from chinchillas in normal physiological condition ("physiological map") and compared these to data previously established from sound overexposed ears ("anatomical map"). The characteristic frequency (CF) of neurons in the cochlear nucleus was determined. Horse-radish peroxidase (HRP) or biocytin (BCT) were injected iontophoretically to trace auditory nerve fibers towards their innervation site in the organ of Corti. The relationship between distance from the base (d, percent) and frequency (f, kHz) was described best by a simple exponential function: d = 61.2 - 42.2 x log(f). The slope of the function was 2.55 mm/octave. Compared to the "anatomical map", the "physiological map" was shifted by about 0.3 octaves to higher frequencies corresponding to a shift of the basilar membrane vibration pattern of 0.8 mm towards the apex for a given stimulus frequency. Our findings affirm that frequency-position maps in the mammalian cochlea depend on the condition of the inner ear. Damage-induced desensitization in mammalian inner ears results in similar shifts of CF (about 0.5 octaves) but different shifts of the maximum of the vibration pattern towards the base at given frequencies, dependent on the mapping constant of the species, longer basilar membranes showing a larger basal shift. Furthermore, the results substantiate the notion that "crowding" at lower frequencies appears to be a specialization rather than a general feature. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Mueller, Marcus; Hoidis, Silvi; Smolders, Jean W. T.] Goethe Univ Frankfurt, Dept Neurophysiol, Ctr Neurosci, D-60590 Frankfurt, Germany.
RP Smolders, JWT (reprint author), Goethe Univ Frankfurt, Dept Neurophysiol, Ctr Neurosci, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM m.mueller@em.uni-frankfurt.de; hoidis@em.uni-frankfurt.de;
jean.smolders@em.uni-frankfurt.de
FU Deutsche Forschungsgemeinschaft [SFB 269]
FX We thank Desiree Biedenkapp and Manuel Groth for technical assistance
and Prof. Jochen Roeper for support and encouragement. We thank Peter
Melzer for critical comments on an earlier version of the manuscript and
an anonymous reviewer of the revised version for his careful reading and
insightful suggestions. The work was supported by a grant from the
Deutsche Forschungsgemeinschaft, SFB 269, B1.
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NR 42
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 184
EP 193
DI 10.1016/j.heares.2010.05.021
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900020
PM 20685384
ER
PT J
AU Altman, JA
Vaitulevich, SP
Shestopalova, LB
Petropavlovskaia, EA
AF Altman, J. A.
Vaitulevich, S. Ph.
Shestopalova, L. B.
Petropavlovskaia, E. A.
TI How does mismatch negativity reflect auditory motion?
SO HEARING RESEARCH
LA English
DT Article
ID RIGHT-HEMISPHERE DOMINANCE; HUMAN BRAIN; TEMPORAL INTEGRATION; SENSORY
MEMORY; STIMULUS DEVIANCE; SPATIAL LOCATION; INTERAURAL TIME; SOUND
LOCATION; INFORMATION; MOVEMENT
AB Recent studies have shown that the mismatch negativity (MMN), a change-specific component of the auditory event-related potential (ERP), is accurately tracking the spatial location of the stationary sound source. The aim of the present study was to estimate the parameters of MMNs evoked by auditory motion and to compare the motion discrimination measured by MMN in normally hearing subjects with the psychophysical data obtained in the same group of subjects. The auditory motion was simulated by introducing variable interaural time differences (ITDs) into the deviant stimuli. The ERPs were recorded for frequently occurring stationary midline standards and for infrequent deviant sounds moving horizontally at different velocities. It was established that all the deviant stimuli elicited significant MMNs. The MMN increased monotonically in amplitude with growing angular distances travelled by the deviant stimuli. The deviants that travelled over the same angular distances at different velocities caused MMNs that agreed in magnitude but differed in latency. These results indicated that the angular distance rather than sound image velocity was the most essential cue involved in the MMN generation. To test the psychophysical performance, a two-interval forced-choice task was employed, in which the ITD was the main dependent variable. The deviants that evoked significant MMNs at the minimal ITDs were not discriminated behaviorally, indicating that the motion discrimination of the hearing system may be better at a preattentive level. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Altman, J. A.; Vaitulevich, S. Ph.; Shestopalova, L. B.; Petropavlovskaia, E. A.] Russian Acad Sci, IP Pavlov Physiol Inst, St Petersburg 199034, Russia.
RP Shestopalova, LB (reprint author), Russian Acad Sci, IP Pavlov Physiol Inst, Nab Makarova 6, St Petersburg 199034, Russia.
EM shestolido@mail.ru
FU Russian Foundation for Fundamental Research [08-04-00006]; Committee for
Leading Scientific Schools [SC-3866.2008.4]
FX This study was supported by the Russian Foundation for Fundamental
Research 08-04-00006 and by the Committee for Leading Scientific Schools
(SC-3866.2008.4).
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NR 42
TC 5
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 194
EP 201
DI 10.1016/j.heares.2010.06.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900021
PM 20542103
ER
PT J
AU Stecker, GC
AF Stecker, G. Christopher
TI Trading of interaural differences in high-rate Gabor click trains
SO HEARING RESEARCH
LA English
DT Article
ID LATERAL SUPERIOR OLIVE; LOW-FREQUENCY NEURONS; SOUND LOCALIZATION;
INTENSITY DIFFERENCES; BINAURAL INTERACTION; INFERIOR COLLICULUS;
INTERCLICK INTERVAL; LEVEL DIFFERENCES; TIME DIFFERENCES; GUINEA-PIG
AB In this study, combinations of interaural time differences (ITD) and interaural level differences (ILD) were applied to trains of 4000 Hz Gabor clicks (Gaussian-filtered impulses) and presented to listeners over headphones. ITD/ILD equivalence functions, or "trading ratios" (TR) were estimated using two different procedures: a "closed-loop" procedure in which subjects adjusted (via head-turn) the ILD of a target click train to counteract the effects of an imposed ITD, and an "open-loop" procedure in which subjects indicated (also via head-turn) the lateral position of click trains containing independent combinations of ITD and ILD. For both tasks, TR values increasingly favored ILD over ITD as inter-click interval (ICI) decreased from 10 to 2 ms. Subsequent analysis confirmed that this change reflected a loss of sensitivity to envelope ITD at short ICI rather than a gain in sensitivity to ILD, consistent with prior studies demonstrating rate-limited processing of ongoing envelope ITD. Significant intersubject differences in the data included two subjects whose TR values obtained under both procedures were consistently lower (greater influence of ITD) than other subjects', and did not vary with ICI. Such differences suggest that multiple mechanisms of ITD/ILD combination may be utilized to varying degrees by individual listeners. By at least one of those mechanisms, ITD sensitivity (but not ILD sensitivity) is limited to low modulation rates. (C) 2010 Elsevier B.V. All rights reserved.
C1 Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA.
RP Stecker, GC (reprint author), Univ Washington, Dept Speech & Hearing Sci, 1417 NE 42nd St, Seattle, WA 98105 USA.
EM cstecker@uw.edu
FU National Institute On Deafness And Other Communication Disorders (NIDCD)
[R03-DC009482]
FX The author thanks Andrew Brown and Shiboney Dumo for assistance with
data collection. Andrew Brown and two anonymous reviewers provided
helpful feedback on earlier versions of the manuscript. This study was
supported by Grant Number R03-DC009482 from the National Institute On
Deafness And Other Communication Disorders (NIDCD). The content is
solely the responsibility of the authors and does not necessarily
represent the official views of the NIDCD or the National Institutes of
Health. Portions of this work were previously presented in abstract form
(Stecker, 2008).
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NR 67
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 202
EP 212
DI 10.1016/j.heares.2010.06.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900022
PM 20547218
ER
PT J
AU Gander, PE
Bosnyak, DJ
Roberts, LE
AF Gander, P. E.
Bosnyak, D. J.
Roberts, L. E.
TI Evidence for modality-specific but not frequency-specific modulation of
human primary auditory cortex by attention
SO HEARING RESEARCH
LA English
DT Article
ID STEADY-STATE RESPONSES; SELECTIVE ATTENTION; TONOTOPIC ORGANIZATION;
EVOKED-POTENTIALS; VISUAL CORTICES; BASAL FOREBRAIN; FIELDS;
PROJECTIONS; STIMULI; STREAMS
AB We used the stimulus-driven 40-Hz auditory steady-state response (ASSR) that localizes tonotopically to the region of primary auditory cortex (A1) to study modulation of this region by top down attention. Experiment 1 presented amplitude modulated (AM) auditory and visual stimuli simultaneously (AM at 40 Hz and 16 Hz, respectively) while participants responded to targets in one modality or the other. ASSR amplitude increased from an unattended passive baseline during auditory but not visual attention demonstrating modality-specific auditory attention, when attention was required for brief (1 s) but not long (2 min) time intervals. Modality-specific visual attention occurred at both time intervals. Experiment 2 asked whether attention directed to one or the other of two simultaneous auditory streams (carrier frequencies of 250 and 4100 Hz AM at 37 and 41 Hz respectively, counterbalanced) increased ASSR amplitude for the attended stream (frequency-specific auditory attention). Behaviour was strongly controlled by carrier frequency (overall target rate 1.7 Hz), and the cortical sources of the two carriers were resolved by inverse modeling. Despite these conditions favourable to frequency specificity, frequency-specific modulation of ASSR amplitude was not found at either time interval. Frequency-specific modulation of A1 may require re-entrant feedback to the auditory core from auditory percepts that possess distinct spectral attributes and are attended in higher regions of the auditory system. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Gander, P. E.; Bosnyak, D. J.; Roberts, L. E.] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada.
RP Roberts, LE (reprint author), McMaster Univ, Dept Psychol Neurosci & Behav, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.
EM pgander@mcmaster.ca; bosnyak@mcmaster.ca; roberts@mcmaster.ca
FU Canadian Institutes of Health Research; Natural Sciences and Engineering
Research Council of Canada
FX This research was supported by grants from the Canadian Institutes of
Health Research and the Natural Sciences and Engineering Research
Council of Canada (L.E.R.). The authors contributed equally to this
work. P.E.G. is now at the University of Nottingham (UK).
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NR 53
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 213
EP 226
DI 10.1016/j.heares.2010.06.003
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900023
PM 20547217
ER
PT J
AU Ries, DT
Hamilton, TR
Grossmann, AJ
AF Ries, Dennis T.
Hamilton, Traci R.
Grossmann, Aurora J.
TI The effects of intervening interference on working memory for sound
location as a function of inter-comparison interval
SO HEARING RESEARCH
LA English
DT Article
ID MINIMUM AUDIBLE ANGLE; RECOGNITION MEMORY; TIME DIFFERENCES; ABSOLUTE
PITCH; LOCALIZATION; DISCRIMINATION; FREQUENCY; TONES; CUES; THRESHOLDS
AB This study examined the effects of inter-comparison interval duration and intervening interference on auditory working memory (AWM) for auditory location. Interaural phase differences were used to produce localization cues for tonal stimuli and the difference limen for interaural phase difference (DL-IPD) specified as the equivalent angle of incidence between two sound sources was measured in five different conditions. These conditions consisted of three different inter-comparison intervals [300 ms (short), 5000 ms (medium), and 15,000 ms (long)], the medium and long of which were presented both in the presence and absence of intervening tones. The presence of intervening stimuli within the medium and long inter-comparison intervals produced a significant increase in the DL-IPD compared to the medium and long inter-comparison intervals condition without intervening tones. The result obtained in the condition with a short inter-comparison interval was roughly equivalent to that obtained for the medium inter-comparison interval without intervening tones. These results suggest that the ability to retain information about the location of a sound within AWM decays slowly; however, the presence of intervening sounds readily disrupts the retention process. Overall, the results suggest that the temporal decay of information within AWM regarding the location of a sound from a listener's environment is so gradual that it can be maintained in trace memory for tens of seconds in the absence of intervening acoustic signals. Conversely, the presence of intervening sounds within the retention interval may facilitate the use of context memory, even for shorter retention intervals, resulting in a less detailed, but relevant representation of the location that is resistant to further degradation. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Ries, Dennis T.; Hamilton, Traci R.; Grossmann, Aurora J.] Ohio Univ, Sch Hearing Speech & Language Sci, Auditory Percept Lab, Grover Ctr W241, Athens, OH 45701 USA.
RP Ries, DT (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Auditory Percept Lab, Grover Ctr W241, Athens, OH 45701 USA.
EM ries@ohio.edu; th206704@ohio.edu; ag303003@ohio.edu
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NR 46
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 227
EP 233
DI 10.1016/j.heares.2010.06.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900024
PM 20547219
ER
PT J
AU Dehmel, S
Kopp-Scheinpflug, C
Weick, M
Dorrscheidt, GJ
Rubsamen, R
AF Dehmel, Susanne
Kopp-Scheinpflug, Cornelia
Weick, Michael
Doerrscheidt, Gerd J.
Ruebsamen, Rudolf
TI Transmission of phase-coupling accuracy from the auditory nerve to
spherical bushy cells in the Mongolian gerbil
SO HEARING RESEARCH
LA English
DT Article
ID ANTEROVENTRAL COCHLEAR NUCLEUS; SUPERIOR OLIVARY COMPLEX; INTERAURAL
TEMPORAL DISPARITIES; HIGH-FREQUENCY NEURONS; GUINEA-PIG; BRAIN-STEM;
NEURAL SYNCHRONIZATION; COINCIDENCE DETECTION; RESPONSE PROPERTIES;
MERIONES-UNGUICULATUS
AB The phase of low-frequency sinusoids is encoded in phase-coupled discharges of spherical bushy cells (SBCs) of the anteroventral cochlear nucleus and transmitted to the medial superior olive, where binaural input-coincidence is used for processing of sound source localization. SBCs are innervated by auditory nerve fibers through large, excitatory synapses (endbulbs of Held) and by inhibitory inputs, which effectively reduce SBC discharge rates. Here we monitor presynaptic potentials of endbulb-terminals and postsynaptic spikes of SBCs in extracellular single unit recordings in vivo. We compare postsynaptic phase-coupling of SBCs and their presynaptic immediate auditory nerve input. In all but one SBC discharge rates at the characteristic frequency were reduced pre-to-postsynaptically and phase-coupling accuracy was increased in one-third of them. We investigated the contribution of systemic inhibition on spike timing in SBCs by iontophoretic application of glycine- and GABA-receptor antagonists (strychnine, bicuculline). Discharge rate increased in one-third of the units during antagonist application, which was accompanied by a deterioration of phase-coupling accuracy in half of those units. These results suggest that the phase-coupling accuracy is improved in a subpopulation of SBCs during transmission from the auditory nerve to the SBCs by reduction of spike rates. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Dehmel, Susanne; Kopp-Scheinpflug, Cornelia; Ruebsamen, Rudolf] Univ Leipzig, Fac Biosci Pharm & Psychol, D-04103 Leipzig, Germany.
[Weick, Michael] Univ Leipzig, Paul Flechsig Inst Brain Res, D-04109 Leipzig, Germany.
[Doerrscheidt, Gerd J.] Tiefurth Mill, Weimar, Germany.
RP Rubsamen, R (reprint author), Univ Leipzig, Fac Biosci Pharm & Psychol, Talstr 33, D-04103 Leipzig, Germany.
EM rueb@rz.uni-leipzig.de
FU DFG [GRK 1097, Ru 390/18-2]
FX This work was supported by DFG GRK 1097 'InterNeuro' and DFG Ru
390/18-2.
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NR 98
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 234
EP 249
DI 10.1016/j.heares.2010.06.005
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900025
PM 20561574
ER
PT J
AU Wang, Q
Kachelmeier, A
Steyger, PS
AF Wang, Qi
Kachelmeier, Allan
Steyger, P. S.
TI Competitive antagonism of fluorescent gentamicin uptake in the cochlea
SO HEARING RESEARCH
LA English
DT Article
ID SENSORY HAIR-CELLS; GUINEA-PIG COCHLEA; STRIA VASCULARIS; AMINOGLYCOSIDE
ANTIBIOTICS; INNER-EAR; PHARMACOKINETICS; PHARMACOLOGY; CAPILLARIES;
OTOTOXICITY; ENDOCYTOSIS
AB Aminoglycosides enter inner ear hair cells via apical endocytosis, or mechanoelectrical transduction channels, implying that, in vivo, aminoglycosides enter hair cells from endolymph prior to exerting their cytotoxic effect. If so, circulating aminoglycosides likely cross the strial blood-labyrinth barrier and enter marginal cells prior to clearance into endolymph. We characterized the competitive antagonism of unconjugated aminoglycosides on the uptake of fluorescent gentamicin (GM) in the stria vascularis and kidney cells at an early time point.
In mice, uptake of GTTR by kidney proximal tubule cells was competitively antagonized by gentamicin at all doses, but only weakly by kanamycin (mimicking in vitro data). GM fluorescence was similar to 100-fold greater in proximal tubule cells than in the stria vascularis. Furthermore, only high molar ratios of aminoglycosides significantly reduced strial uptake of GTTR. Thus, gentamicin antagonism of GTTR uptake is more efficacious in proximal tubules than in the stria vascularis.
Competitive antagonism of CM uptake is indicative of specific cell-regulatable uptake mechanisms (e.g., ion channels, transporters) in the kidney. Strial uptake mechanisms have lower specific affinity for gentamicin, and/or density (compared to the kidney), yet may be critical to transport gentamicin across the strial blood-labyrinth barrier into marginal cells. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wang, Qi; Kachelmeier, Allan; Steyger, P. S.] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
RP Steyger, PS (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM steygerp@ohsu.edu
FU National Institute of Deafness and other Communication Disorders, NIH
[DC 04555, P30 DC 05983]
FX Funded by DC 04555 and P30 DC 05983 grants from the National Institute
of Deafness and other Communication Disorders, NIH. We thank Anthony
Ricci, Ph.D. of Stanford for discussion on the manuscript.
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NR 33
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 250
EP 259
DI 10.1016/j.heares.2010.06.008
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900026
PM 20561573
ER
PT J
AU Cheng, CH
Hsu, WY
Shih, YH
Lin, HC
Liao, KK
Wu, ZA
Lin, YY
AF Cheng, Chia-Hsiung
Hsu, Wan-Yu
Shih, Yang-Hsin
Lin, Hsuan-Chun
Liao, Kwong-Kum
Wu, Zin-An
Lin, Yung-Yang
TI Differential cerebral reactivity to shortest and longer tones:
Neuromagnetic and behavioral evidence
SO HEARING RESEARCH
LA English
DT Article
ID MISMATCH NEGATIVITY MMN; HUMAN AUDITORY-CORTEX; SOUND DURATION; VOWEL
DURATION; LANGUAGE EXPERIENCE; NATIVE-SPEAKERS; PITCH CHANGES; HUMAN
BRAIN; DISCRIMINATION; MEMORY
AB Detecting a change in sound duration is important in language processing. The cerebral reactivity to a duration deviant in oddball paradigm has been reflected as a mismatch negativity (MMN). This study aimed to see cerebral responses to several duration-varying sounds presented with equal probability. Magnetoencephalographic (MEG) and behavior responses to equi-probable sounds (25-50-75-100-125 ms or 50-75-100-125-150 ms tones) were recorded in 10 healthy adult volunteers. By subtracting the average of the responses to 4 longer tones from the response to the shortest tone, a clear deflection peaking at 100-200 ms from stimulus onset was identified. This activity was called as substandard MMNm, and its amplitude tended to increase with the increment of duration deviance within a stimulation paradigm. The source of sub-standard MMNm was localized in superior temporal area, with 5-6 mm more anterior to the generator of N100m response. Behavioral tests also showed best performance in the recognition of the shortest tone than longer tones. In conclusion, the preferential response to the shortest tone in an equiprobable paradigm suggests an asymmetrical processing in the auditory cortex for duration-varying sounds. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Cheng, Chia-Hsiung; Hsu, Wan-Yu; Lin, Hsuan-Chun; Lin, Yung-Yang] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan.
[Shih, Yang-Hsin; Liao, Kwong-Kum; Wu, Zin-An; Lin, Yung-Yang] Natl Yang Ming Univ, Dept Neurol, Taipei 112, Taiwan.
[Lin, Yung-Yang] Natl Yang Ming Univ, Inst Physiol, Taipei 112, Taiwan.
[Lin, Yung-Yang] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan.
[Cheng, Chia-Hsiung; Hsu, Wan-Yu; Lin, Hsuan-Chun; Lin, Yung-Yang] Taipei Vet Gen Hosp, Neurophysiol Lab, Integrated Brain Res Lab, Taipei 112, Taiwan.
[Shih, Yang-Hsin; Liao, Kwong-Kum; Wu, Zin-An; Lin, Yung-Yang] Taipei Vet Gen Hosp, Neurol Inst, Taipei 112, Taiwan.
RP Lin, YY (reprint author), Natl Yang Ming Univ, Inst Brain Sci, 201,Sec 2,Shih Pai Rd, Taipei 112, Taiwan.
EM yylin@vghtpe.gov.tw
FU Taipei Veterans General Hospital [V95ER3-006, V96ER3-008, V97ER3-006,
VGHUST97-P6-24, V97C1-034, V98ER3-002, VGH-S4-98-018, VGH-S4-98-001,
VGH-ER3-99-006]; National Science Council, Taipei, Taiwan
[NSC-95-2314-B-010-030-MY3, NSC-96-2628-B-010-030-MY3,
NSC98-2321-B-010-007]
FX This study was supported in part by research grants from Taipei Veterans
General Hospital (V95ER3-006, V96ER3-008, V97ER3-006, VGHUST97-P6-24,
V97C1-034; V98ER3-002; VGH-S4-98-018; VGH-S4-98-001; VGH-ER3-99-006) and
from the National Science Council (NSC-95-2314-B-010-030-MY3,
NSC-96-2628-B-010-030-MY3; NSC98-2321-B-010-007), Taipei, Taiwan. We
thank Dr. Ming-Wei Lin for her invaluable assistance in our statistical
analysis.
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NR 56
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 260
EP 270
DI 10.1016/j.heares.2010.06.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900027
PM 20600746
ER
PT J
AU Zhang, HM
Kelly, JB
AF Zhang, Huiming
Kelly, Jack B.
TI Time dependence of binaural responses in the rat's central nucleus of
the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
ID PRIMARY AUDITORY-CORTEX; INTERAURAL INTENSITY DIFFERENCES; SOUND
PRESSURE LEVEL; ALBINO-RAT; NMDA RECEPTORS; MEDIATED INHIBITION; LATERAL
LEMNISCUS; COCHLEAR NUCLEUS; NEURAL RESPONSES; SUPERIOR OLIVE
AB Recordings were made from single neurons in the rat's central nucleus of the inferior colliculus. Excitatory/inhibitory binaural interactions and interaural-level difference curves were determined for responses to 100 ms dichotic tone bursts presented to the left and right ears simultaneously. Most neurons with sustained responses to tone bursts had the same binaural response type throughout the 100 ms stimulus period. However, some neurons (39% of our sample) showed qualitatively different binaural response types during the early and late parts of the stimulus (the first 20 ms versus the last 80 ms of the tone burst). Also, for many neurons with consistent early and late binaural response patterns, the strength of binaural interaction was different during the early and late periods. For example, for neurons excited by the contralateral ear and inhibited by the ipsilateral ear during the entire 100 ms period (the most common binaural response type), the degree of inhibition was generally greater during the later part of a stimulus. This change in the strength and/or quality of binaural interaction during dichotic stimulation likely reflects a complex pattern of converging excitatory and inhibitory inputs to the inferior colliculus from lower brainstem structures as well as the time course of local synaptic events. The temporal properties of binaural interaction may influence how sound source location is represented in the central auditory system. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Zhang, Huiming] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada.
[Kelly, Jack B.] Carleton Univ, Dept Psychol, Ottawa, ON K1S 5B6, Canada.
RP Zhang, HM (reprint author), Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada.
EM hzhang@uwindsor.ca
FU Natural Sciences and Engineering Research Council (NSERC) of Canada;
Hearing Foundation of Canada; University of Windsor
FX This research was supported by grants from the Natural Sciences and
Engineering Research Council (NSERC) of Canada to HZ and JBK, The
Hearing Foundation of Canada, and the University of Windsor.
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NR 56
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP 1
PY 2010
VL 268
IS 1-2
BP 271
EP 280
DI 10.1016/j.heares.2010.06.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 645YA
UT WOS:000281500900028
PM 20600745
ER
PT J
AU Edmondson-Jones, AM
Irving, S
Moore, DR
Hall, DA
AF Edmondson-Jones, A. Mark
Irving, Samuel
Moore, David R.
Hall, Deborah A.
TI Planar localisation analyses: A novel application of a centre of mass
approach
SO HEARING RESEARCH
LA English
DT Article
ID RELEARNING SOUND LOCALIZATION; BINAURAL HEARING; HUMAN LISTENERS;
FERRETS; CUES
AB Sound localisation is one of the key roles for listening, and measuring localisation performance is a mainstay of the hearing research laboratory. Such measurements may consider both accuracy and, for incorrect trials, the size of the error. In terms of error analysis, localisation studies have frequently used general purpose univariate techniques in conjunction with either mean signed or unsigned error measurements. This approach can make inappropriate distributional assumptions and so more suitable alternatives based on directional statistics have also been used. Here we investigate the use of a variety of methods, assess their performance, and comment on their use and availability. We also describe a novel use of a 'centre of mass' approach for describing localisation data jointly in terms of accuracy and size of error. This spatial method offers powerful, yet flexible, statistical analysis using standard multivariate analysis of variance (MANOVA). (C) 2010 Elsevier B.V. All rights reserved.
C1 [Edmondson-Jones, A. Mark; Irving, Samuel; Moore, David R.; Hall, Deborah A.] MRC Inst Hearing Res, Nottingham NG7 2RD, England.
[Edmondson-Jones, A. Mark] E Midlands Publ Hlth Observ, Mansfield NG19 8RL, England.
[Hall, Deborah A.] Nottingham Trent Univ, Sch Social Sci, Div Psychol, Nottingham NG1 4BU, England.
RP Edmondson-Jones, AM (reprint author), MRC Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England.
EM mark.edmondson-jones@empho.nhs.uk
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NR 24
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 4
EP 11
DI 10.1016/j.heares.2010.04.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700002
PM 20438824
ER
PT J
AU Brown, DJ
Patuzzi, RB
AF Brown, Daniel J.
Patuzzi, Robert B.
TI Evidence that the compound action potential (CAP) from the auditory
nerve is a stationary potential generated across dura mater
SO HEARING RESEARCH
LA English
DT Article
ID BRAIN-STEM RESPONSE; GUINEA-PIG COCHLEA; ROUND-WINDOW; SUMMATING
POTENTIALS; ACOUSTIC NEUROMA; FAR-FIELDS; NUCLEUS; ELECTROCOCHLEOGRAPHY;
ORIGIN; RECORDINGS
AB We have investigated the generation of the compound action potential (CAP) from the auditory nerve of guinea pigs. Responses to acoustic tone-bursts were recorded from the round window (RW), throughout the cochlear fluids, from the surface of the cochlear nucleus, from the central end of the auditory nerve after removal of the cochlear nucleus, from the scalp vertex, and from the contralateral ear. Responses were compared before, during and after experimental manipulations including pharmacological blockade of the auditory nerve, section of the auditory nerve, section of the efferent nerves, removal of the cochlear nucleus, and focal cooling of the cochlear nerve and/or cochlear nucleus. Regardless of the waveform changes occurring with these manipulations, the responses were similar in waveform but inverted polarity across the internal auditory meatus. The CAP waveforms were very similar before and after removal of the cochlear nucleus, apart from transient changes that could last many minutes. This suggests that the main CAP components are generated entirely by the eighth nerve. Based on previous studies and a clear understanding of the generation of extracellular potentials, we suggest that the early components in the responses recorded from the round window, from the cochlear fluids, from the surface of the cochlear nucleus, or from the scalp are a far-field or stationary potential, generated when the circulating action currents associated with each auditory neurone encounters a high extracellular resistance as it passes through the dura mater. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
C1 [Brown, Daniel J.] Univ Sydney, Sydney Med Sch, Brain & Mind Res Inst, Camperdown, NSW 2050, Australia.
[Brown, Daniel J.; Patuzzi, Robert B.] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Auditory Lab, Crawley 6009, Australia.
RP Brown, DJ (reprint author), Univ Sydney, Sydney Med Sch, Brain & Mind Res Inst, 100 Mallett St, Camperdown, NSW 2050, Australia.
EM danielbrown@med.usyd.edu.au; rpatuzzi@cyllene.uwa.edu.au
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NR 55
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 12
EP 26
DI 10.1016/j.heares.2010.03.091
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700003
PM 20430085
ER
PT J
AU Tonnaer, ELGM
Peters, TA
Curfs, JHAJ
AF Tonnaer, Edith L. G. M.
Peters, Theo A.
Curfs, Jo H. A. J.
TI Neurofilament localization and phosphorylation in the developing inner
ear of the rat
SO HEARING RESEARCH
LA English
DT Article
ID MARIE-TOOTH-DISEASE; INTERMEDIATE-FILAMENT PROTEINS; PRIMARY AUDITORY
NEURONS; AXONAL-TRANSPORT; SPIRAL GANGLION; LEAD-EXPOSURE; COCHLEAR
INNERVATION; ANTIGEN RETRIEVAL; TRIPLET PROTEINS; GUINEA-PIG
AB Detailed understanding of neurofilament protein distribution in the inner ear can shed light on regulatory mechanisms involved in neuronal development of this tissue. We assessed the spatio-temporal changes in the distribution of neurofilaments in the developing rat inner ear between embryonic day 12 and 30 days after birth, using antibodies against phosphorylated as well as non-phosphorylated light (NFL), medium (NFM) and heavy (NFH) neurofilament subunits. Our results show that during development, the onset of neurofilament expression in the rat inner ear is on embryonic day 12, earlier than previously shown. We demonstrate that neurofilament subunits of different molecular weight emerge in a developmental stage-dependent order. In addition, we determined that neurofilaments of the vestibular nerve mature earlier than neurofilaments of the cochlear nerve. Cochlear neurofilament maturation progresses in a gradient from base to apex, and from inner to outer hair cells. The sequential pattern of neurofilament expression we describe may help understand the consequences of certain mutations, and contribute to develop therapeutic strategies. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Tonnaer, Edith L. G. M.; Peters, Theo A.; Curfs, Jo H. A. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Donders Inst Brain Cognit & Behav,Ctr Neurosci, NL-6500 HB Nijmegen, Netherlands.
RP Tonnaer, ELGM (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Donders Inst Brain Cognit & Behav,Ctr Neurosci, Philips van Leydenlaan 15,POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM E.Tonnaer@kno.umcn.nl; T.Peters@kno.umcn.nl; J.Curfs@kno.umcn.nl
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NR 61
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 27
EP 35
DI 10.1016/j.heares.2010.03.090
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700004
PM 20430081
ER
PT J
AU Francis, NA
Guinan, JJ
AF Francis, Nikolas A.
Guinan, John J., Jr.
TI Acoustic stimulation of human medial olivocochlear efferents reduces
stimulus-frequency and click-evoked otoacoustic emission delays:
Implications for cochlear filter bandwidths
SO HEARING RESEARCH
LA English
DT Article
ID SUPERIOR OLIVARY COMPLEX; AUDITORY-NERVE RESPONSES; TUNING CURVES;
CONTRALATERAL SUPPRESSION; WAVELET ANALYSIS; REFLEX; DEPENDENCE; PHASE;
MODEL; SOUND
AB Filter theory indicates that changes in cochlear filter bandwidths are accompanied by changes in cochlear response latencies. Previous reports indicate that otoacoustic emission (OAE) delays are reduced by exciting medial olivocochlear (MOC) efferents with contralateral broad-band noise (CBBN). These delay reductions are consistent with MOC-induced widening of cochlear filters. We quantified the MOC-induced changes in human cochlear filter-related delays using stimulus-frequency and click-evoked OAEs (SFOAE and CEOAEs), recorded with and without MOC activity elicited by 60 dB SPL CBBN. MOC-induced delay changes were measured from the slopes of SFOAE phase functions and from cross-correlation of 500 Hz-wide CEOAE frequency-band waveform magnitudes. The delay changes measured from CEOAEs and SFOAEs were statistically indistinguishable. Both showed greater delay reductions at lower frequencies (a 5% decrease in the 0.5-2 kHz frequency region). These data indicate that cochlear filters are widened 5% by the MOC activity from moderate-level CBBN. Psychophysically, the large changes in cochlear response latencies, implied by the 0.5 ms change in OAE delay at low frequencies, would have a profound effect on binaural localization if they were not balanced in the central nervous system, or by the MOC system producing similar changes in both ears. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Francis, Nikolas A.; Guinan, John J., Jr.] Harvard MIT Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol, Cambridge, MA 02139 USA.
[Francis, Nikolas A.; Guinan, John J., Jr.] Massachusetts Eye & Ear Infirm, Eaton Peabody Labs Auditory Physiol, Dept Otolaryngol, Boston, MA 02114 USA.
[Guinan, John J., Jr.] Harvard Univ, Dept Otol & Laryngol, Sch Med, Boston, MA 02115 USA.
RP Francis, NA (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM nfu@mit.edu
FU NIH NIDCD [RO1 DC005977, P30 DC005209, T32 DC00038]
FX We thank Radha Kalluri, Jeffery Lichtenhan and Christopher Shera for
comments on the manuscript. Supported by NIH NIDCD RO1 DC005977, P30
DC005209 and T32 DC00038.
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NR 62
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 36
EP 45
DI 10.1016/j.heares.2010.04.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700005
PM 20430088
ER
PT J
AU Martinez-Galan, JR
Perez-Martinez, FC
Juiz, JM
AF Martinez-Galan, Juan R.
Perez-Martinez, Francisco C.
Juiz, Jose M.
TI Differences in glutamate-mediated calcium responses in the ventral
cochlear nucleus and inferior colliculus of the developing rat
SO HEARING RESEARCH
LA English
DT Article
ID AUDITORY BRAIN-STEM; SYNAPTIC-TRANSMISSION; AMPA RECEPTORS;
DEVELOPMENTAL-CHANGES; CA2+ PERMEABILITY; KAINATE RECEPTOR; ENDBULB
SYNAPSES; NMDA RECEPTORS; GUINEA-PIG; NEURONS
AB Using optical recordings of neuronal [Ca(2+)]i in brain slices from young rats (P9-P11), we report distinct regulation of Ca(2+) signalling mediated by the activity of glutamate receptors in the ventral cochlear nucleus (VCN) and the central nucleus of the inferior colliculus (CIC) in the midbrain. [Ca(2+)]i increases were recorded after bath-stimulation of slices with glutamate agonists of both ionotropic (AMPA/kainate or NMDA) and group I metabotropic glutamate receptors (mGluRs).
NMDA-induced [Ca(2+)]i responses were similar in both auditory nuclei. Kainate-induced [Ca(2+)]i increases recorded in the VCN were over two-fold larger than those in the CIC. Blockade of kainate-induced [Ca(2+)]i responses in VCN neurons with 1-naphtylacetyl spermine (NAS) demonstrated that Ca(2+)-permeable AMPA receptors predominated in the VCN. In contrast, abundant Ca(2+)-impermeable AMPA receptors were found in the CIC.
Both mGluR1 and mGluR5 subtypes of group I mGluRs were present in the CIC and the VCN. However, Group I mGluR [Ca(2+)]i responses elicited by DHPG were two fold higher in CIC than in VCN neurons. Therefore, our findings suggest that Ca(2+) signalling in auditory neurons may be differentially regulated at different levels of the auditory pathway through preferential activation of different classes of glutamate receptors, which may have implications for hierarchical auditory signal processing and plasticity, at least during the early developmental stages of hearing. (C) 2010 Elsevier BM. All rights reserved.
C1 [Martinez-Galan, Juan R.; Perez-Martinez, Francisco C.; Juiz, Jose M.] Univ Castilla La Mancha, Ctr Reg Invest Biomed, Dpto Ciencias Med, Inst Invest Discapacidades Neurol,Fac Med, Albacete 02006, Spain.
RP Juiz, JM (reprint author), Univ Castilla La Mancha, Ctr Reg Invest Biomed, Dpto Ciencias Med, Inst Invest Discapacidades Neurol,Fac Med, C Almansa 14, Albacete 02006, Spain.
EM JoseManuel.Juiz@uclm.es
FU MICINN [BFU2006-19374/BFI, BFU2009-13974/BFI]; Consejeria de Sanidad
JCCM [SAN06-009, GCS-2006-C/15]; Consejeria de Educacion JCCM
[PEII09-0152-6233, PII1I09-0056-7896]
FX The authors want to thanks Jose J Cabanes and Maria J Simarro for
technical assistance. Support was provided by Support was provided by
Spain's MICINN grants (BFU2006-19374/BFI and BFU2009-13974/BFI),
Consejeria de Sanidad JCCM (SAN06-009 and GCS-2006-C/15) and Consejeria
de Educacion JCCM (PEII09-0152-6233) grants to JMJ and by Consejeria de
Educacion JCCM (PII1I09-0056-7896) grant to JRMG.
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NR 58
TC 5
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 46
EP 53
DI 10.1016/j.heares.2010.03.089
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700006
PM 20430074
ER
PT J
AU Wei, L
Ding, DL
Sun, W
Xu-Friedman, MA
Salvi, R
AF Wei, Lei
Ding, Dalian
Sun, Wei
Xu-Friedman, Matthew A.
Salvi, Richard
TI Effects of sodium salicylate on spontaneous and evoked spike rate in the
dorsal cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
ID SPONTANEOUS NEURAL ACTIVITY; INHIBITORY POSTSYNAPTIC CURRENTS; HAIR CELL
LOSS; INFERIOR COLLICULUS; INDUCED TINNITUS; AUDITORY-CORTEX; INTENSE
SOUND; INDUCED HYPERACTIVITY; LIMBIC SYSTEM; BRAIN-SLICES
AB Spontaneous hyperactivity in the dorsal cochlear nucleus (DCN), particularly in fusiform cells, has been proposed as a neural generator of tinnitus. To determine if sodium salicylate, a reliable tinnitus inducer, could evoke hyperactivity in the DCN, we measured the spontaneous and depolarization-evoked spike rate in fusiform and cartwheel cells during salicylate superfusion. Five minute treatment with 1.4 mM salicylate suppressed spontaneous and evoked firing in fusiform cells; this decrease partially recovered after salicylate washout. Less suppression and greater recovery occurred with 3 min treatment using 1.4 mM salicylate. In contrast, salicylate had no effect on the spontaneous or evoked firing of cartwheel cells indicating that salicylate's suppressive effects are specific to fusiform cells. To determine if salicylate's suppressive effects were a consequence of increased synaptic inhibition, spontaneous inhibitory postsynaptic currents (IPSC) were measured during salicylate treatment. Salicylate unexpectedly reduced IPSC thereby ruling out increased inhibition as a mechanism to explain the depressed firing rates in fusiform cells. The salicylate-induced suppression of fusiform spike rate apparently arises from unidentified changes in the cell's intrinsic excitability. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wei, Lei; Ding, Dalian; Sun, Wei; Salvi, Richard] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
[Xu-Friedman, Matthew A.] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14214 USA.
RP Salvi, R (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall, Buffalo, NY 14214 USA.
EM lweiub@gmail.com; dding@buffalo.edu; weisun@buffalo.edu; mx@buffalo.edu;
salvi@buffalo.edu
FU NIH [R01DC009091, R01DC009219]; Graduate Student Association at the
University at Buffalo, The State University of New York
FX Research supported in part by grants from NIH (R01DC009091; R01DC009219)
and The Mark Diamond Research Fund of the Graduate Student Association
at the University at Buffalo, The State University of New York.
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NR 74
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 54
EP 60
DI 10.1016/j.heares.2010.03.088
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700007
PM 20430089
ER
PT J
AU Wang, GP
Chatterjee, I
Batts, SA
Wong, HT
Gong, TW
Gong, SS
Raphael, Y
AF Wang, Guo-Peng
Chatterjee, Ishani
Batts, Shelley A.
Wong, Hiu Tung
Gong, Tzy-Wen
Gong, Shu-Sheng
Raphael, Yehoash
TI Notch signaling and Atoh1 expression during hair cell regeneration in
the mouse utricle
SO HEARING RESEARCH
LA English
DT Article
ID CHINCHILLA CRISTA-AMPULLARIS; AVIAN AUDITORY EPITHELIUM; INNER-EAR;
SENSORY EPITHELIA; MORPHOLOGICAL EVIDENCE; GENTAMICIN TREATMENT;
SUPPORTING CELL; ACOUSTIC TRAUMA; MATH1; FATE
AB The mammalian vestibular epithelium has a limited capacity for spontaneous hair cell regeneration. The mechanism underlying the regeneration is not well understood. Because the Notch signaling pathway mediates the formation of the sensory epithelial mosaic patterning during ear development, it may also play a role in hair cell regeneration in the mature mammalian vestibular epithelium after a lesion. To investigate the process of spontaneous regeneration in the vestibular epithelium vis-a-vis changes in Notch signaling, we induced a unilateral lesion by infusing streptomycin into the mouse posterior semicircular canal, and examined Notch signaling molecules and their mRNA expression levels by immunohistochemistry and quantitative real-time polymerase chain reaction (qRTPCR), respectively. We detected Jagged1 in supporting cells in both normal and lesioned utricles. Atoh1, a marker for early developing hair cells, was absent in the intact mature tissue, but re-appeared after the lesion. Many cells were either positive for both Atoh1 and myosin Vila, or for one of them. qRTPCR data showed a post trauma decrease of Hes5 and an increase in Atoh1. Atoh1 up-regulation may either be a result of Hes5 down-regulation or mediated by another signaling pathway. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wang, Guo-Peng; Chatterjee, Ishani; Batts, Shelley A.; Wong, Hiu Tung; Gong, Tzy-Wen; Raphael, Yehoash] Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
[Wang, Guo-Peng; Gong, Shu-Sheng] Huazhong Univ Sci & Technol, Union Hosp, Dept Otolaryngol, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China.
[Batts, Shelley A.] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
[Gong, Shu-Sheng] Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Beijing Tongren Hosp,Ministry Educ, Key Lab Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
RP Raphael, Y (reprint author), MSRB 3,Rm 9301,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
FU A. Alfred Taubman Medical Research Institute; NIH-NIDCD [R01-DC01634,
P30-DC05188]; China Scholarship Council [2008616087]; Natural Science
Foundation of Beijing [7082024]; Science Development Program of Beijing
Municipal Education Commission [KM200810025004]
FX We thank Dr. Jane Johnson for the anti-Atoh1 antibody, and Lisa Beyer
and Donald Swiderski for technical assistance. This work was supported
by the A. Alfred Taubman Medical Research Institute and NIH-NIDCD Grants
R01-DC01634 and P30-DC05188. Guo-Peng Wang received support from the
China Scholarship Council (No. 2008616087), Natural Science Foundation
of Beijing (No. 7082024), and Science Development Program of Beijing
Municipal Education Commission (No. KM200810025004).
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PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 61
EP 70
DI 10.1016/j.heares.2010.03.085
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700008
PM 20433915
ER
PT J
AU Wu, HP
Hsu, CJ
Cheng, TJ
Guo, YL
AF Wu, Hung-Pin
Hsu, Chuan-Jen
Cheng, Tsun-Jen
Guo, Yueliang Leon
TI N-acetylcysteine attenuates noise-induced permanent hearing loss in
diabetic rats
SO HEARING RESEARCH
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; HAIR CELL LOSS;
OXIDATIVE STRESS; THRESHOLD SHIFTS; CARBON-MONOXIDE; ACOUSTIC TRAUMA;
GUINEA-PIG; CHILDREN 6; INNER-EAR
AB The purpose of this study is to investigate whether repeated noise exposure aggravates the level of permanent noise-induced hearing loss (NIHL) in diabetic rats and whether N-acetylcysteine (NAC), a precursor of glutathione, attenuates the level of noise-induced permanent hearing loss in diabetic rats. Fifty male Wistar rats were divided into four groups: 12 non-diabetic control rats with saline injection (Control-Saline), 11 non-diabetic control rats with NAC injection (Control-NAC), 13 streptozotocin-induced diabetic rats with saline injection (Diabetes-Saline) and 14 streptozotocin-induced diabetic rats with NAC injection (Diabetes-NAC). NAC (325 mg/kg) was given by intraperitoneal injection twice per day (bid.) for 14 days starting 2 days before noise exposure. All rats were exposed to noise for 8 hours per day for 10 consecutive days to develop noise-induced permanent hearing loss. The hearing status of all animals was evaluated with auditory brainstem responses (ABR) evoked by clicks and tone bursts. ABRs were measured before and at 1 hour, 1 week, 2 weeks and 4 weeks after noise exposure. After a recovery time of 4 weeks, animals were decapitated, and the loss of hair cells was assessed microscopically. In all groups, ABR thresholds failed to return to pre-exposure values throughout the experimental period. The ABR threshold to clicks was markedly elevated in the Diabetes-Saline group (36.9 +/- 2.3 dB SPL), less elevated in the Control-Saline and Diabetes-NAC groups and least in the Control-NAC group (19.5 +/- 2.0 dB SPL) at 4 weeks after noise exposure. Diabetes caused increased susceptibility to noise-induced hearing loss, and NAC treatment reduced the loss in both control and diabetic rats. Cochleograms revealed no gross destruction of hair cells in the non-diabetic groups or the Diabetes-NAC group; however, a significant number of outer hair cells (OHCs) were lost in the Diabetes-Saline group. This study demonstrated that diabetics were prone to developing more severe NIHL than non-diabetics and that NAC could preserve most OHCs and attenuate the permanent noise-induced hearing loss in both groups. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Cheng, Tsun-Jen; Guo, Yueliang Leon] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei 100, Taiwan.
[Hsu, Chuan-Jen; Cheng, Tsun-Jen; Guo, Yueliang Leon] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan.
[Wu, Hung-Pin; Cheng, Tsun-Jen; Guo, Yueliang Leon] Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan.
[Wu, Hung-Pin] Buddhist Tzuchi Gen Hosp, Dept Otolaryngol, Taipei Branch, Taipei, Taiwan.
[Wu, Hung-Pin] Buddhist Tzuchi Gen Hosp, Dept Otolaryngol, Taichung Branch, Taipei, Taiwan.
[Wu, Hung-Pin] Tzuchi Univ, Sch Med, Hualien, Taiwan.
[Hsu, Chuan-Jen] Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 100, Taiwan.
RP Guo, YL (reprint author), Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, 17,Syujhou Rd, Taipei 100, Taiwan.
EM leonguo@ntu.edu.tw
RI Cheng, Tsun-Jen /D-3495-2012
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NR 44
TC 12
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 71
EP 77
DI 10.1016/j.heares.2010.03.082
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700009
PM 20430080
ER
PT J
AU Lanting, CP
de Kleine, E
Eppinga, RN
van Dijk, P
AF Lanting, C. P.
de Kleine, E.
Eppinga, R. N.
van Dijk, P.
TI Neural correlates of human somatosensory integration in tinnitus
SO HEARING RESEARCH
LA English
DT Article
ID PRIMARY AUDITORY-CORTEX; GAZE-EVOKED TINNITUS; SUPERIOR TEMPORAL PLANE;
INDUCED HEARING-LOSS; COCHLEAR NUCLEUS; MULTISENSORY CONVERGENCE;
ASSOCIATION CORTEX; CEREBELLAR VERMIS; GUINEA-PIG; FMRI
AB Possible neural correlates of somatosensory modulation of tinnitus were assessed. Functional magnetic resonance imaging (fMRI) was used to investigate differences in neural activity between subjects that can modulate their tinnitus by jaw protrusion and normal hearing controls. We measured responses to bilateral sound and responses to jaw protrusion. Additionally we studied multimodal integration of somatosensory jaw protrusion and sound. The auditory system responded to both sound and jaw protrusion. Jaw responses were enhanced in the cochlear nucleus (CN) and the inferior colliculus (IC) in tinnitus patients. The responses of the auditory brain areas to jaw protrusion presumable account for the modulation of tinnitus as described by the patients. The somatosensory system responded to jaw protrusion and not to sound. These responses occurred both in subjects with tinnitus and controls. Unexpectedly, the cerebellum responded to sound in normal hearing subjects, but not in tinnitus patients. Together, these results provide a neurophysiological basis for the effect of jaw protrusion on tinnitus. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Lanting, C. P.; de Kleine, E.; Eppinga, R. N.; van Dijk, P.] Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, Groningen, Netherlands.
[Lanting, C. P.; de Kleine, E.; Eppinga, R. N.; van Dijk, P.] Univ Groningen, Fac Med Sci, Sch Behav & Cognit Neurosci, NL-9700 AB Groningen, Netherlands.
RP Lanting, CP (reprint author), MRC Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England.
EM cris@ihr.mrc.ac.uk; e.de.kleine@med.umcg.nl; p.van.dijk@med.umcg.nl
RI Van Dijk, Pim/E-8019-2010; de Kleine, Emile/P-2350-2014
OI Van Dijk, Pim/0000-0002-8023-7571;
FU Heinsius Houbolt Foundation; Netherlands Organization for Scientific
Research (NWO)
FX This work was supported by the Heinsius Houbolt Foundation and the
Netherlands Organization for Scientific Research (NWO). The study is
part of the research program of our department: Communication through
Hearing and Speech.
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NR 67
TC 15
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 78
EP 88
DI 10.1016/j.heares.2010.04.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700010
PM 20430086
ER
PT J
AU Ito, K
Chihara, Y
Iwasaki, S
Komuta, Y
Sugasawa, M
Sahara, Y
AF Ito, Ken
Chihara, Yasuhiro
Iwasaki, Shinichi
Komuta, Yukari
Sugasawa, Masashi
Sahara, Yoshinori
TI Functional ligand-gated purinergic receptors (P2X) in rat vestibular
ganglion neurons
SO HEARING RESEARCH
LA English
DT Article
ID MODULATES COCHLEAR MECHANICS; PHARMACOLOGICAL EVIDENCE; MOLECULAR
PHYSIOLOGY; GUINEA-PIG; ATP; CELLS; ADENOSINE; CHANNELS; CURRENTS;
SUBUNIT
AB The expression of purinergic receptors (P2X) on rat vestibular ganglion neurons (VGNs) was examined using whole-cell patch-clamp recordings. An application of adenosine 5'-triphosphate (ATP: 100 mu M) evoked inward currents in VGNs at a holding potential of -60 mV. The decay time constant of the ATP-evoked currents was 2-4 s, which is in between the values for rapidly desensitizing subgroups (P2X1 and P2X3) and slowly desensitizing subgroups (P2X2, P2X4, etc.), suggesting the heterogeneous expression of P2X receptors. A dose-response experiment showed an EC(50) of 11.0 mu M and a Hill's coefficient of 0.82. Suramin (100 mu M) reversibly inhibited the ATP-evoked inward currents. Alpha, beta-methylene ATP (100 mu M), a P2X-specific agonist, also evoked inward currents but less extensively than ATP. An application of adenosine 5'-dihosphate (ADP; 100 mu M) evoked similar, but much smaller, currents. The current-voltage relationship of the ATP-evoked conductance showed pronounced inward rectification with a reversal potential more positive than 0 mV, suggesting non-selective cation conductance. However, the channel was not permeable to a large cation (N-methyl-D-glucamine) and acidification (pH 6.3) had little effect on the ATP-evoked conductance. RT-PCR confirmed the expression of five subtypes (P2X2-P2X6) in VGNs. The physiological role of P2X receptors includes the modulation of excitability at the synapses between hair cells and dendrites and/or trophic support (or also neuro-modulation) from supporting cells surrounding the VGNs. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Ito, Ken] Teikyo Univ, Dept Otolaryngol, Fac Med, Itabashi Ku, Tokyo 1738605, Japan.
[Ito, Ken; Chihara, Yasuhiro; Iwasaki, Shinichi] Univ Tokyo, Dept Otolaryngol, Fac Med, Tokyo 113, Japan.
[Komuta, Yukari; Sahara, Yoshinori] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Div Biochem & Cellular Biol, Kodaira, Tokyo 187, Japan.
[Sugasawa, Masashi] Saitama Med Coll, Dept Otolaryngol, Moroyama, Saitama, Japan.
[Sahara, Yoshinori] Tsurumi Univ, Dept Physiol, Sch Dent Med, Yokohama, Kanagawa, Japan.
RP Ito, K (reprint author), Teikyo Univ, Dept Otolaryngol, Fac Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM itoken-tky@umin.ac.jp
FU Japanese Ministry of Education, Science, Sports and Culture [C-17591778,
C-18791190]
FX The first and second authors contributed equally to this article. This
work was supported by grants from the Japanese Ministry of Education,
Science, Sports and Culture (C-17591778 and C-18791190). This study was
presented at the 43rd Inner Ear Biology Workshop, Sep 17-20, 2006,
Montpellier, France, and at the 31st Annual Mid Winter Meeting of the
Association for Research in Otolaryngology. Feb 16-21, 2008, Phoenix,
AZ, USA.
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NR 34
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 89
EP 95
DI 10.1016/j.heares.2010.03.081
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700011
PM 20430087
ER
PT J
AU Brimijoin, WO
O'Neill, WE
AF Brimijoin, W. Owen
O'Neill, William E.
TI Patterned tone sequences reveal non-linear interactions in auditory
spectrotemporal receptive fields in the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
ID COMBINATION-SENSITIVE NEURONS; FREQUENCY-MODULATED STIMULI; SHORT-TERM
ADAPTATION; MOUSTACHED BAT; NATURAL SOUNDS; MUSTACHE BAT; BIOSONAR
SIGNALS; CORTICAL-NEURONS; COCHLEAR NUCLEUS; TUNED NEURONS
AB Linear measures of auditory receptive fields do not always fully account for a neuron's response to spectrotemporally-complex signals such as frequency-modulated sweeps (FM) and communication sounds. A possible source of this discrepancy is cross-frequency interactions, common response properties which may be missed by linear receptive fields but captured using two-tone masking. Using a patterned tonal sequence that included a balanced set of all possible tone-to-tone transitions, we have here combined the spectrotemporal receptive field with two-tone masking to measure spectrotemporal response maps (STRM). Recording from single units in the mustached bat inferior colliculus, we found significant non-linear interactions between sequential tones in all sampled units. In particular, tone-pair STRMs revealed three common features not visible in linear single-tone STRMs: 1) two-tone facilitative interactions, 2) frequency-specific suppression, and 3) post-stimulatory suppression in the absence of spiking. We also found a correlative relationship between these nonlinear receptive field features and sensitivity for different rates and directions of FM sweeps, dynamic features found in many vocalizations, including speech. The overwhelming prevalence of cross-frequency interactions revealed by this technique provides further evidence of the central auditory system's role as a pattern-detector, and underscores the need to include nonlinearity in measures of the receptive field. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Brimijoin, W. Owen; O'Neill, William E.] Univ Rochester, Dept Brain & Cognit Sci, Coll Arts Sci & Engn, Rochester, NY 14627 USA.
[O'Neill, William E.] Univ Rochester, Dept Neurobiol & Anat, Ctr Nav & Commun Sci, Sch Med & Dent, Rochester, NY 14642 USA.
RP Brimijoin, WO (reprint author), Glasgow Royal Infirm, MRC Inst Hearing Res, Scottish Sect, Queen Elizabeth Bldg,16 Alexandra Parade, Glasgow G31 2ER, Lanark, Scotland.
EM owen@ihr.gla.ac.uk
FU National Institute for Deafness and Communicative Disorders (NIDCD)
[R01-DC03717]; National Institute of Mental Health [5 T32 MH19942-07]
FX This research was supported by a grant from the National Institute for
Deafness and Communicative Disorders (NIDCD R01-DC03717) and from a
National Institute of Mental Health Training Grant (5 T32 MH19942-07).
We thank William Vaughn for generating a pseudo-random sequence and
Editor Dan Sanes and two anonymous reviewers for invaluable comments.
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NR 79
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 96
EP 110
DI 10.1016/j.heares.2010.04.005
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700012
PM 20430078
ER
PT J
AU Li, SF
Li, HW
Wang, ZM
AF Li, Shufeng
Li, Huawei
Wang, Zhengmin
TI Orientation of spiral ganglion neurite extension in electrical fields of
charge-balanced biphasic pulses and direct current in vitro
SO HEARING RESEARCH
LA English
DT Article
ID SENSORINEURAL HEARING-LOSS; SENSORY AXON REGENERATION; GROWTH CONE
GUIDANCE; DEAFENED GUINEA-PIG; AUDITORY-NERVE; COCHLEAR IMPLANTATION;
SPINAL-CORD; STIMULATION; SURVIVAL; NEURONS
AB Cochlear implants function by stimulating residual spiral ganglion neurons (SGNs) with electric current. Promoting the neurites of SGNs to grow towards an electrode array could improve the outcome of cochlear implantation. Several studies have suggested that DC electrical fields (EFs) can affect the direction of neurite extension. To investigate the impact of steady DC EFs, pulsed DC EFs and charge-balanced biphasic pulsed EFs on the direction of SON neurite extension, we established an SON culturing and imaging system. SGN explants of newborn Sprague-Dawley rats were cultured on slides. Slides were positioned into the monitoring system with neurite terminals in a certain orientation and location, while the migration of SON growth cones was monitored by taking serial photos. Deflection angles of neurites at a certain period were measured. In steady or pulsed DC EFs, neurites on laminin-coated slides turned towards the cathode, while those on PDL-coated slides turned towards the anode. The neurites in charge-balanced biphasic pulsed EFs had an obvious orientation of turning away from the electrode rings. This orientation diminished with increasing distance from the electrode rings and followed the nonuniform characteristics of charge-balanced biphasic pulsed EFs. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Li, Shufeng; Li, Huawei; Wang, Zhengmin] Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, Shanghai 200031, Peoples R China.
RP Wang, ZM (reprint author), Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, 83 Fenyang Rd, Shanghai 200031, Peoples R China.
EM lisf@fudan.edu.cn; hwli@shmu.edu.cn; fjswzm@gmail.com
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NR 36
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 111
EP 118
DI 10.1016/j.heares.2010.04.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700013
PM 20430073
ER
PT J
AU Mellott, JG
Van der Gucht, E
Lee, CC
Carrasco, A
Winer, JA
Lomber, SG
AF Mellott, Jeffrey G.
Van der Gucht, Estel
Lee, Charles C.
Carrasco, Andres
Winer, Jeffery A.
Lomber, Stephen G.
TI Areas of cat auditory cortex as defined by neurofilament proteins
expressing SMI-32
SO HEARING RESEARCH
LA English
DT Article
ID ANTERIOR ECTOSYLVIAN SULCUS; LATERAL GENICULATE-NUCLEUS; PRIMARY
VISUAL-CORTEX; ECHIDNA TACHYGLOSSUS-ACULEATUS; CALCIUM-BINDING PROTEINS;
PYRAMIDAL NEURONS; CEREBRAL-CORTEX; MACAQUE MONKEY; ARCHITECTONIC
SUBDIVISIONS; PARAHIPPOCAMPAL CORTICES
AB The monoclonal antibody SMI-32 was used to characterize and distinguish individual areas of cat auditory cortex. SMI-32 labels non-phosphorylated epitopes on the high- and medium-molecular weight subunits of neurofilament proteins in cortical pyramidal cells and dendritic trees with the most robust immunoreactivity in layers III and V. Auditory areas with unique patterns of immunoreactivity included: primary auditory cortex (AI), second auditory cortex (AII), dorsal zone (DZ), posterior auditory field (PAF), ventral posterior auditory field (VPAF), ventral auditory field (VAF), temporal cortex (T), insular cortex (IN), anterior auditory field (AAF), and the auditory field of the anterior ectosylvian sulcus (fAES). Unique patterns of labeling intensity, soma shape, soma size, layers of immunoreactivity, laminar distribution of dendritic arbors, and labeled cell density were identified. Features that were consistent in all areas included: layers I and IV neurons are immunonegative: nearly all immunoreactive cells are pyramidal: and immunoreactive neurons are always present in layer V. To quantify the results, the numbers of labeled cells and dendrites, as well as cell diameter, were collected and used as tools for identifying and differentiating areas. Quantification of the labeling patterns also established profiles for ten auditory areas/layers and their degree of immunoreactivity. Areal borders delineated by SMI-32 were highly correlated with tonotopically-defined areal boundaries. Overall, SMI-32 immunoreactivity can delineate ten areas of cat auditory cortex and demarcate topographic borders. The ability to distinguish auditory areas with SMI-32 is valuable for the identification of auditory cerebral areas in electrophysiological, anatomical, and/or behavioral investigations. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Mellott, Jeffrey G.; Carrasco, Andres; Lomber, Stephen G.] Univ Western Ontario, Ctr Brain & Mind, Dept Physiol & Pharmacol, Schulich Sch Med & Dent, London, ON N6A 5C1, Canada.
[Mellott, Jeffrey G.] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
[Van der Gucht, Estel] Katholieke Univ Leuven, Lab Neuroplast & Neuroprote, Louvain, Belgium.
[Lee, Charles C.] Univ Chicago, Dept Neurobiol, Chicago, IL 60637 USA.
[Winer, Jeffery A.] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA.
[Mellott, Jeffrey G.; Carrasco, Andres; Lomber, Stephen G.] Univ Western Ontario, Dept Psychol, Cerebral Syst Lab, London, ON, Canada.
RP Lomber, SG (reprint author), Univ Western Ontario, Ctr Brain & Mind, Dept Physiol & Pharmacol, Schulich Sch Med & Dent, Med Sci Bldg,Room 216,1151 Richmond St N, London, ON N6A 5C1, Canada.
EM steve.lomber@uwo.ca
RI Lomber, Stephen/B-6820-2015
OI Lomber, Stephen/0000-0002-3001-7909
FU Canadian Institutes of Health Research; Natural Sciences and Engineering
Research Council of Canada; National Institute on Deafness and Other
Communication Disorders
FX We thank Sang Keun (Sam) Yi for assistance in the histological
preparation of tissue and Amee J. Hall with assistance in preparing the
manuscript. This work was supported by grants from the Canadian
Institutes of Health Research, Natural Sciences and Engineering Research
Council of Canada, and the National Institute on Deafness and Other
Communication Disorders.
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NR 97
TC 24
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 119
EP 136
DI 10.1016/j.heares.2010.04.003
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700014
PM 20430082
ER
PT J
AU Schulz-Mirbach, T
Ladich, F
Riesch, R
Plath, M
AF Schulz-Mirbach, Tanja
Ladich, Friedrich
Riesch, Ruediger
Plath, Martin
TI Otolith morphology and hearing abilities in cave- and surface-dwelling
ecotypes of the Atlantic molly, Poecilia mexicana (Teleostei:
Poeciliidae)
SO HEARING RESEARCH
LA English
DT Article
ID INNER-EAR; ASTYANAX-FASCIATUS; SOUND PRODUCTION; VATERITE; FISH;
POPULATIONS; ARAGONITE; FORM; AUDIOGRAMS; PHYSIOLOGY
AB Cave fish have rarely been investigated with regard to their inner ear morphology, hearing abilities, and acoustic communication. Based on a previous study that revealed morphological differences in the saccular otolith between a cave and two surface populations of Poecilia mexicana, we checked for additional differences in utricular and lagenar otoliths and tested whether different populations have similar hearing sensitivities. We found pronounced differences in the shape of all three otoliths. Otoliths of the saccule and lagena from cave fish differed from those of surface fish in the features of the face oriented towards the sensory epithelium. In addition, otoliths of the utricle and lagena were significantly heavier in cave fish. Auditory sensitivities were measured between 100 and 1500 Hz, utilizing the auditory evoked potential recording technique. We found similar hearing abilities in cave and surface fish, with greatest sensitivity between 200 and 300 Hz. An acoustic survey revealed that neither ecotype produced species-specific sounds. Our data indicate that cave dwelling altered the otolith morphology in Atlantic mollies, probably due to metabolic differences. Different otolith morphology, however, did not affect general auditory sensitivity or acoustic behavior. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Schulz-Mirbach, Tanja] Univ Munich, Dept Earth & Environm Sci, D-80333 Munich, Germany.
[Ladich, Friedrich] Univ Vienna, Dept Behav Biol, A-1090 Vienna, Austria.
[Riesch, Ruediger] Univ Oklahoma, Dept Zool, Norman, OK 73019 USA.
[Plath, Martin] Goethe Univ Frankfurt, Dept Ecol & Evolut, D-60054 Frankfurt, Germany.
RP Schulz-Mirbach, T (reprint author), Univ Munich, Dept Earth & Environm Sci, Richard Wagner Str 10, D-80333 Munich, Germany.
EM t.schulz-mirbach@lrz.uni-muenchen.de; friedrich.ladich@univie.ac.at;
ruedigerriesch@ou.edu; mplath@bio.uni-frankfurt.de
RI Riesch, Rudiger/A-5787-2008
FU University of Bavaria; Austrian Science Fund [FWF 22319]; Graduate
College of the University of Oklahoma; DFG [PL 470/1-2]
FX We wish to thank W. Lechner, L E. Wysocki, and S. Papes for assistance
during auditory measurements, R. Melzer for providing access to the SEM
at the Zoological State Collection (Munich) and M. Stachowitsch for
professional scientific English proofreading. For constructive comments
on the manuscript we thank two anonymous reviewers. This study was
funded by a postdoctoral fellowship of the University of Bavaria e.V.
('Bayerische Eliteforderung'; T. Schulz-Mirbach), the Austrian Science
Fund (FWF 22319 to FL) and by a Robberson Research Grant from the
Graduate College of the University of Oklahoma (R. Riesch). M. Plath
acknowledges financial support from DFG ('Deutsche
Forschungsgemeinschaft', PL 470/1-2).
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NR 56
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 1
PY 2010
VL 267
IS 1-2
BP 137
EP 148
DI 10.1016/j.heares.2010.04.001
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 631MO
UT WOS:000280351700015
PM 20430090
ER
PT J
AU Demeester, K
van Wieringen, A
Hendrickx, JJ
Topsakal, V
Huyghe, J
Fransen, E
Van Laer, L
Van Camp, G
Van de Heyning, P
AF Demeester, Kelly
van Wieringen, Astrid
Hendrickx, Jan-jaap
Topsakal, Vedat
Huyghe, Jeroen
Fransen, Erik
Van Laer, Lut
Van Camp, Guy
Van de Heyning, Paul
TI Heritability of audiometric shape parameters and familial aggregation of
presbycusis in an elderly Flemish population
SO HEARING RESEARCH
LA English
DT Article
DE Audiometric configuration; Presbycusis; Heritability; Familial
aggregation; Epidemiology; Age-related hearing impairment
ID HEARING-LOSS; ENVIRONMENTAL-INFLUENCES; ODDS-RATIO; IMPAIRMENT; NOISE;
MODELS; RISK
AB This study describes the heritability of audiometric shape parameters and the familial aggregation of different types of presbycusis in a healthy, otologically screened population between 50 and 75 years old. About 342 siblings of 64 families (average family-size: 5.3) were recruited through population registries. Audiometric shape was mathematically quantified by objective parameters developed to measure size, slope, concavity, percentage of frequency-dependent and frequency-independent hearing loss and Bulge Depth. The heritability of each parameter was calculated using a variance components model. Logistic regression models were used to estimate the odds ratios (ORs). Estimates of sibling recurrence risk ratios (lambda(s)) are also provided. Heritability estimates were generally higher compared to previous studies. ORs and lambda(s) for the parameters Total Hearing Loss (size), Uniform Hearing Loss (percentage of frequency-dependent hearing loss) and Bulge Depth suggest a higher heredity for severe types of presbycusis compared to moderate or mild types. Our results suggest that the separation of the parameter 'Total Hearing Loss' into the two parameters 'Uniform Hearing Loss' and 'Non-uniform Hearing Loss' could lead to the discovery of different genetic subtypes of presbycusis. The parameter 'Bulge Depth', instead of 'Concavity', seemed to be an important parameter for classifying subjects into 'susceptible' or 'resistant' to societal or intensive environmental exposure. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Demeester, Kelly; Topsakal, Vedat; Van de Heyning, Paul] Univ Hosp Antwerp UZA, B-2650 Edegem, Belgium.
[Demeester, Kelly; Topsakal, Vedat; Van de Heyning, Paul] Univ UA, Dept Otolaryngol, B-2650 Edegem, Belgium.
[Demeester, Kelly; van Wieringen, Astrid] Katholieke Univ Leuven, Dept Neurosci, B-3000 Louvain, Belgium.
[Hendrickx, Jan-jaap; Huyghe, Jeroen; Fransen, Erik; Van Laer, Lut; Van Camp, Guy] Univ Antwerp UA, Dept Med Genet, B-2650 Antwerp, Belgium.
[Fransen, Erik] Univ Antwerp, StatUA Stat Ctr, B-2000 Antwerp, Belgium.
RP Demeester, K (reprint author), Univ Antwerp Hosp, Dept Otolaryngol, Wilrijkstr 10, B-2650 Antwerp, Belgium.
EM kelly.demeester@ua.ac.be; Astrid.vanWierin-gen@med.kuleuven.be;
Jan-jaap.hendrickx@ua.ac.be; lazvedat@gmail.com; jeroen.Huyghe@ua.ac.be;
erik.fransen@ua.ac.be; lut.vanlaer@ugent.be; guy.vancam-p@ua.ac.be;
paul.van.de.heyning@telenet.be
RI Van Camp, Guy/F-3386-2013; Fransen, Erik/C-4102-2015
OI Van Camp, Guy/0000-0001-5105-9000; Fransen, Erik/0000-0001-7785-4790
FU British Royal National Institute for the Deaf (RNID); EU
[QLRT-2001-00331]; FWO-Vlaanderen [G.0131.04]; University of Antwerp
FX The authors would like to thank all participants for their voluntary
cooperation. Pieter Baekeland is gratefully acknowledged for the
mathematical support and guidance during the development process of all
the parameters in this study as well as for the implementation of the
algorithms in an Excel query for the automatic calculation of all
individual parameters. This study is supported by Grants of the British
Royal National Institute for the Deaf (RNID), the EU 5th Framework
Quality of Life Programme (QLRT-2001-00331), the FWO-Vlaanderen
(G.0131.04) and the University of Antwerp (TOP Grant).
CR Age-related Hearing Impairment project, 2007, AGE RELATED HEARING
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NR 40
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2010.03.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000001
PM 20303401
ER
PT J
AU Marcusohn, Y
Ar, A
Dirckx, JJJ
AF Marcusohn, Yael
Ar, Amos
Dirckx, Joris J. J.
TI Perfusion and diffusion limitations in middle ear gas exchange: The
exchange of CO2 as a test case
SO HEARING RESEARCH
LA English
DT Article
ID MASTOID PNEUMATIZATION; MUCOSA; PRESSURE; PERMEABILITY; ABSORPTION;
POCKETS; MONKEYS; VOLUME; RAT
AB A long standing debate on perfusion/diffusion limitations in the context of middle ear (ME) gas exchange was revisited using data obtained from previous iso-pressure gas-exchange measurements in different mammals. We tried to determine whether the exchange of CO2 in the ME is limited by perfusion or by diffusion by comparing the mass specific cardiac output (ms(Q)over dot) and the mass specific initial CO2 flow rate into air-washed MEs (ms(V)over dot(1)CO(2)) of rabbits and rats. Based on previously published allometry at rest, the ms(Q)over dot was 0.154 mL/(min g) in rabbits (mean body weight: 2800 g) and 0.259 mL/(min g) in rats (mean body weight: 179.1 g); ms(V)over dot(1)CO(2) (Delta t = 0) was 0.109 +/- 0.047 mu L/(h g) in rabbits (n = 16) and 0.170 +/- 0.094 mu L/(h g) in rats (n = 9). Similar ratios were found when an allometric comparison was made between the ratio of ms(V)over dot(1)CO(2) (Delta t = 0) (similar to 0.64), and the ratio of ms(Q)over dot s (similar to 0.59) in rabbits and rats.
If the active mucosal surface areas of MEs of rabbits and rats are directly proportional to their masses as are the masses of their hearts and if their ms(Q)over dots are proportional to the rates of blood flows in the ME mucosa, these results support the assumption that the exchange of CO2 in the ME of mammals is mainly perfusion (and not diffusion) dependent. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Marcusohn, Yael; Dirckx, Joris J. J.] Univ Antwerp, Lab Biomed Phys, B-2020 Antwerp, Belgium.
[Ar, Amos] Tel Aviv Univ, Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel.
RP Dirckx, JJJ (reprint author), Univ Antwerp, Lab Biomed Phys, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
EM Joris.Dirckx@ua.ac.be
FU University of Antwerp [BOF/44750]; Fund for Scientific Research (FWO);
Nicholas and Elizabeth Shlezak Super Center for Cardiology and
Biomedical Engineering, Tel Aviv University [940110]
FX The study in rabbits was supported by a Grant from the University of
Antwerp (NOI Project No. BOF/44750) and by Grants from the Fund for
Scientific Research (FWO). One of the authors (A.A.) was partially
supported by the Nicholas and Elizabeth Shlezak Super Center for
Cardiology and Biomedical Engineering, Tel Aviv University (No. 940110).
The authors thank Fred Wiese and William Deblauwe for their technical
assistance.
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NR 27
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 11
EP 14
DI 10.1016/j.heares.2010.03.078
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000002
PM 20338231
ER
PT J
AU Schmidt, E
Wolski, TP
Kulesza, RJ
AF Schmidt, Elise
Wolski, Thomas P., Jr.
Kulesza, Randy J., Jr.
TI Distribution of perineuronal nets in the human superior olivary complex
SO HEARING RESEARCH
LA English
DT Article
ID CHONDROITIN SULFATE PROTEOGLYCANS; CENTRAL-NERVOUS-SYSTEM; LATERAL
GENICULATE-NUCLEUS; CALCIUM-BINDING PROTEINS; VENTRAL COCHLEAR NUCLEUS;
AUDITORY BRAIN-STEM; EXTRACELLULAR-MATRIX; RAT-BRAIN; TRAPEZOID BODY;
MEDIAL NUCLEUS
AB Perineuronal nets (PNNs) are specialized assemblies of chondroitin sulfate proteoglycans (CSPGs) in the central nervous system that form a lattice-like covering over the cell body, primary dendrites and initial axon segment of select neuronal populations. PNNs appear to play significant roles in development of the central nervous system, neuronal protection, synaptic plasticity and local ion homeostasis. In seven human brainstems (average age = 81 years), we have utilized Wisteria floribunda (WFA) histochemistry and immunocytochemistry for CSPG to map the distribution of PNNs within the nuclei of the human superior olivary complex (SOC). Within the SOC, the majority of net-bearing neurons are situated in the most medially situated nuclei, especially the superior paraolivary nucleus and medial nucleus of the trapezoid body. Net-bearing neurons are consistently found in the ventral nucleus of the trapezoid body and posterior periolivary nucleus, but to a lesser extent in the lateral nucleus of the trapezoid body. Finally, perineuronal nets are typically absent from the lateral and medial superior olives. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Schmidt, Elise; Wolski, Thomas P., Jr.; Kulesza, Randy J., Jr.] Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
RP Kulesza, RJ (reprint author), Lake Erie Coll Osteopath Med, Auditory Res Ctr, 1858 W Grandview Blvd, Erie, PA 16509 USA.
EM rkulesza@lecom.edu
FU LECOM Research Collective; Deafness Research Foundation
FX This work was supported by the LECOM Research Collective and a grant
from the Deafness Research Foundation. The author would like to thank
Nell Cant for providing the WFA cat slides and to the two anonymous
reviewers for their many helpful comments.
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NR 69
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 15
EP 24
DI 10.1016/j.heares.2010.03.077
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000003
PM 20307636
ER
PT J
AU Eastwood, H
Chang, A
Kel, G
Sly, D
Richardson, R
O'Leary, SJ
AF Eastwood, Hayden
Chang, Andrew
Kel, Gordana
Sly, David
Richardson, Rachael
O'Leary, Stephen J.
TI Round window delivery of dexamethasone ameliorates local and remote
hearing loss produced by cochlear implantation into the second turn of
the guinea pig cochlea
SO HEARING RESEARCH
LA English
DT Article
ID DRUG-DELIVERY; INNER-EAR; CONSERVES HEARING; RESIDUAL HEARING;
PERILYMPH; PRESERVATION; GADOLINIUM; FREQUENCY; SURGERY; THERAPY
AB Application of dexamethasone to the round window has been shown to ameliorate high frequency hearing loss resulting from the trauma of cochlear implantation in experimental animals, but elucidation of the factors influencing protection of the high frequencies has been confounded by the local trauma from electrode array insertion. In this experiment, a second turn cochleostomy and implantation was performed on guinea pigs, to examine protection in the basal turn without the confounding effect of local trauma, as well as to test the efficacy of hearing protection in the second cochlear turn. The implantation resulted in an increase in hearing thresholds across all frequencies examined (2-32 kHz). Local delivery of dexamethasone to the round window prior to implantation protected hearing across frequencies from 2 to 32 kHz. Auditory thresholds improved over the first week after surgery, and then remained stable for the month of the experiment. The protection of hearing in the basal turn increased with longer periods of drug application prior to implantation. The level of hearing protection in the second turn was similar irrespective of the time that the drug was applied, but was greater when a higher steroid concentration was used. It was concluded that steroids protect hearing in the basal turn of the cochlea even when there was no local trauma. The level of hearing protection in the second turn exceeded that expected from models of steroid diffusion through the cochlea, suggesting that inner ear surgery alters the distribution of dexamethasone within the cochlea. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
C1 [O'Leary, Stephen J.] Univ Melbourne, Dept Otolaryngol, Royal Victorian Eye & Ear Hosp, Melbourne E, Vic 3002, Australia.
[Eastwood, Hayden; Chang, Andrew; Kel, Gordana; Sly, David; Richardson, Rachael; O'Leary, Stephen J.] Univ Melbourne, Dept Otolaryngol, Melbourne E, Vic 3002, Australia.
[Richardson, Rachael; O'Leary, Stephen J.] Bion Ear Inst, Melbourne, Australia.
RP O'Leary, SJ (reprint author), Univ Melbourne, Dept Otolaryngol, Royal Victorian Eye & Ear Hosp, Melbourne E, Vic 3002, Australia.
EM sjoleary@unimelb.edu.au
FU Rodney Williams and Garnett Passe Memorial Foundation; NHMRC; NIDCD
[HHS-N-263-2007-00053-C;]
FX The authors wish to acknowledge the generous assistance of the Rodney
Williams and Garnett Passe Memorial Foundation and NHMRC project grant
for funding this project, The Royal Victorian Eye and Ear Hospital for
providing facilities, Maria Clarke and Prudence Nielsen for preparation
of histological slides, Associate Professor John L. Slavin (MBBS, FRCPA)
and the St. Vincent's Hospital Melbourne, Anatomical Pathology
Department for reviewing the histology, Dr. James Fallon for providing
the ABR analysis program (NIDCD Contract HHS-N-263-2007-00053-C; PI:
R.K. Shepherd) and Helen Feng for manufacturing the electrode arrays.
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NR 20
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 25
EP 29
DI 10.1016/j.heares.2010.03.006
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000004
PM 20303400
ER
PT J
AU Deike, S
Scheich, H
Brechmann, A
AF Deike, Susann
Scheich, Henning
Brechmann, Andre
TI Active stream segregation specifically involves the left human auditory
cortex
SO HEARING RESEARCH
LA English
DT Article
ID PERCEPTUAL ORGANIZATION; TONE SEQUENCES; SONGBIRD FOREBRAIN; TEMPORAL
STRUCTURE; DECISION-PROCESSES; PLANUM TEMPORALE; HESCHLS GYRUS; HUMAN
BRAIN; PITCH; REPRESENTATION
AB An important aspect of auditory scene analysis is the sequential grouping of similar sounds into one "auditory stream" while keeping competing streams separate. In the present low-noise fMRI study we presented sequences of alternating high-pitch (A) and low-pitch (B) complex harmonic tones using acoustic parameters that allow the perception of either two separate streams or one alternating stream. However, the subjects were instructed to actively and continuously segregate the A from the B stream. This was controlled by the additional instruction to listen for rare level deviants only in the low-pitch stream.
Compared to the control condition in which only one non-separable stream was presented the active segregation of the A from the B stream led to a selective increase of activation in the left auditory cortex (AC). Together with a similar finding from a previous study using a different acoustic cue for streaming, namely timbre, this suggests that the left auditory cortex plays a dominant role in active sequential stream segregation. However, we found cue differences within the left AC: Whereas in the posterior areas, including the planum temporale, activation increased for both acoustic cues, the anterior areas, including Heschl's gyrus, are only involved in stream segregation based on pitch. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Deike, Susann; Scheich, Henning; Brechmann, Andre] Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany.
RP Deike, S (reprint author), Leibniz Inst Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany.
EM sdeike@ifn-magdeburg.de
FU Deutsche Forschungsgemeinschaft [SFB/TRR31]
FX This work was supported by the "Deutsche Forschungsgemeinschaft"
[SFB/TRR31].
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NR 70
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 30
EP 37
DI 10.1016/j.heares.2010.03.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000005
PM 20233603
ER
PT J
AU Strimbu, CE
Kao, A
Tokuda, J
Ramunno-Johnson, D
Bozovic, D
AF Strimbu, C. E.
Kao, A.
Tokuda, J.
Ramunno-Johnson, D.
Bozovic, D.
TI Dynamic state and evoked motility in coupled hair bundles of the
bullfrog sacculus
SO HEARING RESEARCH
LA English
DT Article
ID SPONTANEOUS OTOACOUSTIC EMISSIONS; GUINEA-PIG COCHLEA; MECHANOELECTRICAL
TRANSDUCTION; OTOLITHIC-MEMBRANE; SPONTANEOUS OSCILLATIONS; MECHANICAL
TRANSDUCTION; ACTIVE PROCESS; TIP LINKS; CELLS; ADAPTATION
AB Spontaneous oscillations, one of the signatures of the active process in non-mammalian hair cells, have been shown to occur in individual hair bundles that have been fully decoupled from the overlying membrane. Here we use semi-intact preparations of the bullfrog sacculus to demonstrate that under more natural loading conditions, innate oscillations are suppressed by the presence of the overlying otolithic membrane, indicating that hair bundles lie in the quiescent rather than the unstable regime. Transepithelial electrical stimulation was then used to test the effect of evoking entrained hair bundle movement with an external stimulus. Firstly, we used a preparation in which the otolithic membrane has been partially detached, coupling only hair bundles of comparable orientations. Secondly, we deposited artificial polymer membranes on top of the epithelium so as to connect to only 10-20 cells. In both of these systems, hair bundle motion phase-locked by the electrical signal was found to induce movement in the overlying structures. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Bozovic, D.] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA.
Calif NanoSyst Inst, Los Angeles, CA 90095 USA.
RP Bozovic, D (reprint author), Univ Calif Los Angeles, Dept Phys & Astron, 475 Portola Plaza, Los Angeles, CA 90095 USA.
EM strimbu@physics.ucla.edu; alkao@physics.ucla.edu; josht75580@aim.com;
dameinrj@physics.ucla.edu; bozovic@physics.ucla.edu
FU NSF [IOS-0920696]; Julian Schwinger Foundation [JS08080000]
FX We thank Prof. Katsushi Arisaka on the use of and consultation regarding
the Photron CMOS camera. Lea Fredrickson provided extensive comments on
the manuscript, and Van Mai contributed to the preparation of the PAMs.
This work was funded in part by NSF Grant IOS-0920696 and in part by the
Julian Schwinger Foundation Grant JS08080000.
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NR 57
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 38
EP 45
DI 10.1016/j.heares.2010.03.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000006
PM 20227476
ER
PT J
AU Gnansia, D
Pressnitzer, D
Pean, V
Meyer, B
Lorenzi, C
AF Gnansia, Dan
Pressnitzer, Daniel
Pean, Vincent
Meyer, Bernard
Lorenzi, Christian
TI Intelligibility of interrupted and interleaved speech for normal-hearing
listeners and cochlear implantees
SO HEARING RESEARCH
LA English
DT Article
ID TEMPORAL FINE-STRUCTURE; MASKING RELEASE; RECOGNITION; PERCEPTION;
NOISE; USERS; MODEL; INTERFERENCE; ORGANIZATION; MASKERS
AB Speech intelligibility is degraded in the presence of a competing talker for cochlear implantees, presumably because of impaired tracking and integration of speech segments glimpsed in the masker valleys. This hypothesis was tested by assessing the intelligibility of periodically-interrupted bisyllables produced by a male and female talker, for normal-hearing listeners and implantees. A 4-Hz square-wave modulator with random phase was used to interrupt bisyllables from each talker. Stimuli were either presented alone (Experiment I) or interleaved (Experiment II: the two talkers were alternated). In Experiment I. the mean identification score for each voice was 88% for normal-hearing listeners and 35% for implantees. In Experiment II, the mean score corresponding to correct identification of both voices was 50% for normal-hearing listeners and 5% for implantees. lmplantees identified at least one bisyllable among the two well above chance level but showed difficulties assigning it to the correct talker. This suggests that implantees can make use of partial information, but cannot track and integrate the non-adjacent components of interleaved speech as well as normal-hearing listeners. Additional results obtained with normal-hearing listeners tested with tone-vocoded syllables suggest that impaired tracking/integration for implantees stems from limited reception of spectral and temporal fine structure cues. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Gnansia, Dan; Pressnitzer, Daniel; Lorenzi, Christian] Ecole Normale Super, Dept Etud Cognit, F-75005 Paris, France.
[Gnansia, Dan; Pressnitzer, Daniel; Lorenzi, Christian] Univ Paris 05, CNRS, UMR 8158, Lab Psychol Percept, F-75006 Paris, France.
[Gnansia, Dan; Pressnitzer, Daniel; Lorenzi, Christian] Ecole Normale Super, F-75006 Paris, France.
[Gnansia, Dan; Pressnitzer, Daniel; Pean, Vincent; Meyer, Bernard; Lorenzi, Christian] Ecole Normale Super, GRAEC, CNRS 2967, GDR, F-75005 Paris, France.
[Gnansia, Dan; Pean, Vincent] MXM Neurelec France, F-06224 Vallauris, France.
[Meyer, Bernard] Univ Paris 06, Hop Beaujon, AP HP, F-75252 Paris 05, France.
RP Gnansia, D (reprint author), Ecole Normale Super, Dept Etud Cognit, 29 Rue Ulm, F-75005 Paris, France.
EM dan.gnansia@ens.fr
RI Lorenzi, Christian/F-5310-2012; Pressnitzer, Daniel/F-6092-2012
FU CIFRE MXM-Neurelec; GDR CNRS GRAEC [2967]
FX This research was supported by a CIFRE MXM-Neurelec grant to D. Gnansia,
and GDR CNRS GRAEC #2967. The authors wish to thank two anonymous
reviewers for valuable comments and suggestions on a previous version of
this manuscript.
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NR 34
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 46
EP 53
DI 10.1016/j.heares.2010.02.012
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000007
PM 20197084
ER
PT J
AU Wesolek, CM
Koay, G
Heffner, RS
Heffner, HE
AF Wesolek, Christina M.
Koay, Gimseong
Heffner, Rickye S.
Heffner, Henry E.
TI Laboratory rats (Rattus norvegicus) do not use binaural phase
differences to localize sound
SO HEARING RESEARCH
LA English
DT Article
DE Sound localization; Evolution; Binaural cues; Interaural time
difference; Onset cue
ID INTERAURAL TIME DIFFERENCES; AUDITORY CORTICAL-LESIONS; FERRET
MUSTELA-PUTORIUS; ALBINO-RAT; INFERIOR COLLICULUS; LATERAL LEMNISCUS;
DORSAL NUCLEUS; CORTEX; CUES; TRANSIENTS
AB The ability of Norway rats to use binaural time- and intensity-difference cues to localize sound was investigated by determining their ability to localize pure tones from 500 Hz to 32 kHz. In addition, their ability to use the binaural time cues present in the envelope of a signal was determined by presenting them with a 1-kHz tone that was amplitude modulated at either 250 or 500 Hz. Although the animals were easily able to localize tones above 2 kHz, indicating that they could use the binaural intensity-difference cue, they were virtually unable to localize the lower-frequency stimuli, indicating that they could not use the binaural phase (time) cue. Although some animals showed a residual ability to localize low-frequency tones, control tests indicated that they were using the transient interaural intensity difference in the onset of a sound that exists after it reaches the near ear but before it reaches the far ear. Thus, in contrast to earlier studies, we conclude that the Norway rat is unable to use the ongoing time cues available in low-frequency tones to localize sound, raising the possibility that the rat may not use interaural time differences to localize sound. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wesolek, Christina M.; Koay, Gimseong; Heffner, Rickye S.; Heffner, Henry E.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
RP Heffner, HE (reprint author), Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
EM hheffne@pop3.utoledo.edu
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NR 37
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 54
EP 62
DI 10.1016/j.heares.2010.02.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000008
PM 20184949
ER
PT J
AU Chen, GD
Kermany, MH
D'Elia, A
Ralli, M
Tanaka, C
Bielefeld, EC
Ding, D
Henderson, D
Salvi, R
AF Chen, Guang-Di
Kermany, Mohammad Habiby
D'Elia, Alessandra
Ralli, Massimo
Tanaka, Chiemi
Bielefeld, Eric C.
Ding, Dalian
Henderson, Donald
Salvi, Richard
TI Too much of a good thing: Long-term treatment with salicylate
strengthens outer hair cell function but impairs auditory neural
activity
SO HEARING RESEARCH
LA English
DT Article
ID INDUCED HEARING-LOSS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; C6
GLIOMA-CELLS; SODIUM-SALICYLATE; INDUCED OTOTOXICITY; PRESTIN
EXPRESSION; GUINEA-PIG; ASPIRIN; NOISE; ACTIVATION
AB Aspirin has been extensively used in clinical settings. Its side effects on auditory function, including hearing loss and tinnitus, are considered as temporary. A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). To follow up on these observations, we carried out two studies, one planned study of age-related hearing loss restoration and a second unrelated study of salicylate-induced tinnitus. Rats of different strains and ages were injected with salicylate at a dose of 200 mg/kg/day for 5 days per week for 3 weeks or at higher dose levels (250-350 mg/kg/day) for 4 days per week for 2 weeks. Unexpectedly, while an enhanced or sustained DPOAE was seen, permanent reductions in the amplitude of the cochlear compound action potential (CAP) and the auditory brainstem response (ABR) were often observed after the chronic salicylate treatment. The mechanisms underlying these unexpected, permanent salicylate-induced reductions in neural activity are discussed. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Chen, Guang-Di; Kermany, Mohammad Habiby; D'Elia, Alessandra; Ralli, Massimo; Tanaka, Chiemi; Bielefeld, Eric C.; Ding, Dalian; Henderson, Donald; Salvi, Richard] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14260 USA.
[D'Elia, Alessandra] Univ Bari, Bari, Italy.
[Ralli, Massimo] Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
RP Chen, GD (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14260 USA.
EM gchen7@buffalo.edu
RI Bielefeld, Eric/D-2015-2012; Ralli, Massimo/D-8641-2013
FU NIH [R01DC006862, R01DC006630, R01DC009091, R01DC009219]; NIOSH
[R01OH008113]; Tinnitus Research Initiative
FX Research supported in part by grants from NIH (R01DC006862, DH;
R01DC006630, R01DC009091, and R01DC009219, RS), NIOSH (R01OH008113, DH),
and Tinnitus Research Initiative (RS).
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NR 81
TC 27
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 63
EP 69
DI 10.1016/j.heares.2010.02.010
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000009
PM 20214971
ER
PT J
AU Palmgren, B
Jin, Z
Ma, HM
Jiao, Y
Olivius, P
AF Palmgren, Bjorn
Jin, Zhe
Ma, Hongmin
Jiao, Yu
Olivius, Petri
TI beta-Bungarotoxin application to the round window: An in vivo
deafferentation model of the inner ear
SO HEARING RESEARCH
LA English
DT Article
ID COCHLEAR NEURONAL DEGENERATION; SPIRAL GANGLION NEURONS; HAIR CELL LOSS;
AUDITORY-NERVE; HEARING-LOSS; GUINEA-PIG; STEM-CELLS; SCALA TYMPANI;
NEUROPATHY; MECHANISMS
AB Hearing impairment can be caused by a primary lesion to the spiral ganglion neurons (SGNs) with the hair cells kept intact, for example via tumours, trauma or auditory neuropathy. To mimic these conditions in animal models various methods of inflicting damage to the inner ear have been used. However, only a few methods have a selective effect on the SGNs, which is of importance since it might be clinically more relevant to study hearing impairment with the hair cells undamaged. beta-Bungarotoxin is a venom of the Taiwan banded krait, which in vitro has been shown to induce apoptosis in neurons, leaving remaining cochlear cells intact. We wanted to create an in vivo rat model of selective damage to primary auditory neurons. Under deep anaesthesia, 41 rats received beta-Bungarotoxin or saline to the round window niche. At postoperative intervals between days 3 and 21 auditory brainstem response (ABR) measurement, immunohistochemistry, SGN quantification and cochlear surface preparation were performed. The results in the beta-Bungarotoxin-treated ears, as compared with sham-operated ears, show significantly increased ABR thresholds at all postoperative intervals, illustrating a severe to profound hearing loss at all tested frequencies (3.5, 7, 16 and 28 kHz). Quantification of the SGNs showed no obvious reduction in neuronal numbers until 14 days postoperatively. Between days 14 and 21 a significant reduction in SGN numbers was observed. Cochlear surface preparation and immunohistochemistry showed that the hair cells were intact. Our results illustrate that in vivo application of beta-Bungarotoxin to the round window niche is a feasible way of deafening rats by SGN reduction while the hair cells are kept intact. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Palmgren, Bjorn; Olivius, Petri] Karolinska Univ Hosp, Karolinska Inst, Sect Otorhinolaryngol, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
[Palmgren, Bjorn; Ma, Hongmin; Jiao, Yu; Olivius, Petri] Karolinska Univ Hosp, Ctr Hearing & Commun Res, S-17176 Stockholm, Sweden.
[Jin, Zhe] Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden.
RP Palmgren, B (reprint author), Karolinska Univ Hosp, Karolinska Inst, Sect Otorhinolaryngol, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
EM bjorn.palmgren@karolinska.se
FU Swedish Scientific Research Council; Marianne and Marcus Wallenberg
Foundation; Foundation Tysta Skolan; Organization for Hard of Hearing
People
FX This work was supported by the Swedish Scientific Research Council, The
Marianne and Marcus Wallenberg Foundation, The Foundation Tysta Skolan
and the Organization for Hard of Hearing People.
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NR 46
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 70
EP 76
DI 10.1016/j.heares.2010.02.009
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000010
PM 20184947
ER
PT J
AU Wang, WH
Yang, JJ
Lin, YC
Yang, JT
Li, SY
AF Wang, Wen-Hung
Yang, Jiann-Jou
Lin, Yen-Chun
Yang, Jen-Tsung
Li, Shuan-Yow
TI Novel expression patterns of connexin 30.3 in adult rat cochlea
SO HEARING RESEARCH
LA English
DT Article
DE Cx30.3; Immunohistochemistry; Laser capture microdissection; Cochlea
ID NONSYNDROMIC HEARING-LOSS; MOUSE INNER-EAR; GAP-JUNCTIONS; STRIA
VASCULARIS; ERYTHROKERATODERMIA VARIABILIS; MOLECULAR-CLONING;
MUTATIONS; CELLS; GENE; DEAFNESS
AB Mutations of the GJB4 gene, encoding connexin 30.3 (CX30.3), are associated with skin disorders. Recently, this gene was also detected in deaf individuals without skin disorders. However, the functional roles of CX30.3 in the cochlea remain unclear. A primary step toward understanding the role of CX30.3 in hearing and its dysfunction is the documentation of its cellular and sub-cellular locations within the cochlea. In the present study, we located and determined the cellular expression of Cx30.3 within the rat cochlea by using a polyclonal anti-Cx30.3 antibody. Expression of the Cx30.3 protein was detected in the spiral limbus, spiral ligament, spiral ganglion, and stria vascularis by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analyses. Our results indicate the presence and localization of Cx30.3 in the rat cochlea. Knowledge of the spatial distribution of Cx30.3 will provide important insights into its role in the cochleae and normal auditory function. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Yang, Jiann-Jou; Li, Shuan-Yow] Chung Shan Med Univ, Genet Lab, Taichung, Taiwan.
[Yang, Jiann-Jou; Li, Shuan-Yow] Chung Shan Med Univ, Dept Biomed Sci, Taichung, Taiwan.
[Yang, Jiann-Jou; Li, Shuan-Yow] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
[Yang, Jen-Tsung] Chang Gung Mem Hosp, Dept Neurosurg, Chiayi, Taiwan.
[Wang, Wen-Hung; Lin, Yen-Chun] Chang Gung Mem Hosp, Dept Otolaryngol, Chiayi, Taiwan.
RP Li, SY (reprint author), Chung Shan Med Univ, Genet Lab, Taichung, Taiwan.
EM syl@csmu.edu.tw
RI Yang, Jen-Tsung/C-3187-2011
FU Chang Gung Memorial Hospital; Graduate Institute of Clinical Medical
Sciences, Chang Gung University College of Medicine [CMRPG650171,
CMRPG660041]
FX This work was supported by the Chang Gung Memorial Hospital and the
Graduate Institute of Clinical Medical Sciences, Chang Gung University
College of Medicine (CMRPG650171 and CMRPG660041).
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NR 36
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 77
EP 82
DI 10.1016/j.heares.2010.02.008
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000011
PM 20184948
ER
PT J
AU Stankovic, KM
Adachi, O
Tsuji, K
Kristiansen, AG
Adams, JC
Rosen, V
McKenna, MJ
AF Stankovic, Konstantina M.
Adachi, Osamu
Tsuji, Kunikazu
Kristiansen, Arthur G.
Adams, Joe C.
Rosen, Vicki
McKenna, Michael J.
TI Differences in gene expression between the otic capsule and other bones
SO HEARING RESEARCH
LA English
DT Article
DE Otic capsule; opg; Bmpr1b; Otosclerosis
ID CHICKEN INNER-EAR; MORPHOGENETIC PROTEINS; CLASS DISCOVERY;
MESSENGER-RNA; MOUSE LIMB; OTOSCLEROSIS; ASSOCIATION; PATTERNS; COL1A1;
NOGGIN
AB Our long term goal is to understand the molecular pathology of otosclerosis and to develop better forms of therapy. Toward this goal, the current study focused on characterizing the molecular factors responsible for the unique biological features of the otic capsule: its minimal rate of remodeling, and lack of healing capacity when fractured. We compared expression levels of 62 genes involved in bone metabolism between the adult murine otic capsule and the tibia and parietal bones; the latter exemplify bones formed by endochondral and intramembranous ossification, respectively. Gene expression levels were measured using real-time quantitative RT-PCR and analyzed using tools of bioinformatics. Expression patterns of key genes were verified with in situ hybridization. The molecular profile of the otic capsule was distinctly different from that of the tibia and parietal bone. Genes found to be most characteristic of the otic capsule were: osteoprotegerin (opg), bone morphogenetic protein receptor 1b (bmpr1b) and bone morphogenetic protein 3 (bmp3). Expression levels were high for opg and bmpr1b, and minimal for bmp3 within the otic capsule. We concluded that opg and bmpr1b likely play important roles in inhibition of remodeling within the otic capsule. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Stankovic, Konstantina M.; Adachi, Osamu; Kristiansen, Arthur G.; Adams, Joe C.; McKenna, Michael J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Stankovic, Konstantina M.; Adachi, Osamu; Kristiansen, Arthur G.; Adams, Joe C.; McKenna, Michael J.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA.
[Stankovic, Konstantina M.; Adachi, Osamu; Adams, Joe C.; McKenna, Michael J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Tsuji, Kunikazu; Rosen, Vicki] Harvard Univ, Sch Dent Med, Boston, MA 02115 USA.
RP Stankovic, KM (reprint author), Massachusetts Eye & Ear Infirm Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
EM konstantina_stankovic@meei.harvard.edu; osamu_adachi@meei.harvard.edu;
kunikazu_tsuji@hsdm.harvard.edu; kris@epl.meei.harvard.edu;
jca@meei.harvard.edu; vicki_rosen@hsdm.harvard.edu;
michael_mckenna@meei.harvard.edu
FU NIDCD [5RO1 DCO3401-06]; American Otological Association; Massachusetts
Life Sciences Center
FX We thank Dr. Saumil Merchant for helpful comments on earlier versions of
the manuscript. This work was supported by NIDCD Grant 5RO1 DCO3401-06
(M.J.M.), American Otological Association (K.M.S.), Massachusetts Life
Sciences Center (K.M.S.) and Mr. Lakshmi Mittal (M.J.M.).
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GENEPATTERN
NR 52
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 83
EP 89
DI 10.1016/j.heares.2010.02.006
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000012
PM 20146935
ER
PT J
AU Ikeda, R
Nakaya, K
Yamazaki, M
Oshima, T
Kawase, T
Kobayashi, T
AF Ikeda, Ryoukichi
Nakaya, Kazuhiro
Yamazaki, Muneharu
Oshima, Takeshi
Kawase, Tetsuaki
Kobayashi, Toshimitsu
TI Effect of vestibular labyrinth destruction on endocochlear potential and
potassium concentration of the cochlea
SO HEARING RESEARCH
LA English
DT Article
DE Endocochlear potential; Semicircular canal; Potassium; Labyrinthectomy
ID SEMICIRCULAR CANAL OCCLUSION; FROG RANA-ESCULENTA; GUINEA-PIGS;
TRANSLABYRINTHINE APPROACH; HEARING PRESERVATION; ION-TRANSPORT; DARK
CELLS; CHANNEL; FLUID; TRANSECTION
AB Partial labyrinthectomy can result in maintenance of hearing under certain circumstances, and the mechanism of the hearing impairment caused by labyrinthectomy is unclear. We hypothesized that disruption of the membranous labyrinth results in electrical leakage and electrolyte imbalance. This study investigated the change in cochlear function by measurement of endocochlear potential (EP) and potassium concentration ([K(+)]) caused by vestibular labyrinth destruction in the acute phase. Hartley guinea pigs underwent lateral semicircular canal (LSCC) transection with suctioning of the perilymph, ampullectomy, or destruction of the LSCC, superior SCC, and lateral part of the vestibule. The EP and [K(+)] were monitored using double-barreled ion-selective microelectrodes in the second turn of cochlea. The EP showed little to mild change after LSCC transectioning or ampullectomy, but declined variously and drastically after vestibulotomy. The EP did not recover but [K(+)] partially recovered after vestibulotomy. Disturbance of the mechanism of cochlear function caused by vestibular labyrinth destruction may involve reduction in the [K(+)] concentration in the endolymph. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ikeda, Ryoukichi; Nakaya, Kazuhiro; Yamazaki, Muneharu; Oshima, Takeshi; Kawase, Tetsuaki; Kobayashi, Toshimitsu] Tohoku Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Aoba Ku, Sendai, Miyagi 9808574, Japan.
RP Ikeda, R (reprint author), Tohoku Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan.
EM ryoukich@hotmail.com
FU Ministry of Education, Science and Culture [21390457]
FX This study was supported by a grant from the Ministry of Education,
Science and Culture [Grant-in-Aid for Scientific Research (B) 21390457].
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NR 30
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 14
PY 2010
VL 265
IS 1-2
BP 90
EP 95
DI 10.1016/j.heares.2009.12.027
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 614XB
UT WOS:000279092000013
PM 20045046
ER
PT J
AU Cruickshanks, KJ
Nondahl, DM
Tweed, TS
Wiley, TL
Klein, BEK
Klein, R
Chappell, R
Dalton, DS
Nash, SD
AF Cruickshanks, Karen J.
Nondahl, David M.
Tweed, Ted S.
Wiley, Terry L.
Klein, Barbara E. K.
Klein, Ronald
Chappell, Rick
Dalton, Dayna S.
Nash, Scott D.
TI Education, occupation, noise exposure history and the 10-yr cumulative
incidence of hearing impairment in older adults
SO HEARING RESEARCH
LA English
DT Article
DE Presbyacusis; Socioeconomic status; Incidence; Hearing impairment;
Hearing loss; Aging
ID HIGH BLOOD-PRESSURE; BEAVER DAM EYE; CARDIOVASCULAR-DISEASE;
SEX-DIFFERENCES; EPIDEMIOLOGY; PREVALENCE; HEALTH; AGE; THRESHOLDS; MICE
AB The purpose of this study was to determine the 10-yr cumulative incidence of hearing impairment and associations of education, occupation and noise exposure history with the incidence of hearing impairment in a population-based cohort study of 3753 adults ages 48-92 yr at the baseline examinations during 1993-1995 in Beaver Dam, WI. Hearing thresholds were measured at baseline, 2.5 yr-, 5 yr-, and 10-yr follow-up examinations. Hearing impairment was defined as a pure-tone average (PTA) > 25 dB HL at 500, 1000, 2000, and 4000 Hz. Demographic characteristics and occupational histories were obtained by questionnaire. The 10-yr cumulative incidence of hearing impairment was 37.2%. Age (5 yr; Hazard Ratio (HR) = 1.81), sex (M vs W; HR = 2.29), occupation based on longest held job (production/operations/farming vs others; HR = 1.34), marital status (unmarried vs married; HR = 1.29) and education (<16 vs 16 + yr; HR = 1.40) were associated with the 10 yr incidence. History of noisy jobs was not associated with the 10-yr incidence of hearing impairment. The risk of hearing impairment was high, with women experiencing a slightly later onset. Markers of socioeconomic status were associated with hearing impairment, suggesting that hearing impairment in older adults may be associated with modifiable lifestyle and environmental factors, and therefore, at least partially preventable. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Cruickshanks, Karen J.; Nondahl, David M.; Tweed, Ted S.; Klein, Barbara E. K.; Klein, Ronald; Dalton, Dayna S.] Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI 53705 USA.
[Cruickshanks, Karen J.; Nash, Scott D.] Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI 53705 USA.
[Tweed, Ted S.; Wiley, Terry L.] Univ Wisconsin, Dept Commun Disorders, Madison, WI 53705 USA.
[Chappell, Rick] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53705 USA.
[Chappell, Rick] Univ Wisconsin, Dept Stat, Madison, WI 53705 USA.
RP Cruickshanks, KJ (reprint author), Univ Wisconsin, Dept Ophthalmol & Visual Sci, Sch Med & Publ Hlth, 610 Walnut St,10th Floor WARF, Madison, WI 53726 USA.
EM cruickshanks@episense.wisc.edu; nondah-l@episense.wisc.edu;
tedt@tds.net; terry.wiley@asu.e-du; kleinb@epi.ophth.wisc.edu;
kleinr@epi.ophth.wisc.edu; chappell@stat.wisc.edu;
dalton@episense.wisc.edu; nash@episense.wisc.edu
FU National Institutes of Health [AG11099, EY06592]
FX This research is supported by National Institutes of Health Grant
AG11099 (K.J. Cruickshanks) and EY06592 (R. Klein).
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NR 47
TC 37
Z9 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 3
EP 9
DI 10.1016/j.heares.2009.10.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100002
PM 19853647
ER
PT J
AU Allen, PD
Eddins, DA
AF Allen, Paul D.
Eddins, David A.
TI Presbycusis phenotypes form a heterogeneous continuum when ordered by
degree and configuration of hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE Presbycusis; Age-related hearing loss; Audiometric configuration; ISO
7029; ANSI S3.44
ID OTOACOUSTIC EMISSION RESPONSES; AUDITORY BRAIN-STEM; HUMAN TEMPORAL
BONE; AUDIOMETRIC PATTERNS; SPEECH RECOGNITION; AGE; INDIVIDUALS;
THRESHOLDS; GERBIL; POPULATION
AB Many reports have documented age-by-frequency increases in average auditory thresholds in various human populations. Despite this, the prevalence of different patterns of hearing loss in presbycusis remains uncertain. We examined 'presbycusis phenotypes' in a database of 960 subjects (552 female, 408 male, 18-92 years) that each had 30 measures of peripheral hearing sensitivity: pure tone audio-grams for left and right ears from 0.25 to 8 kHz and DPOAE for each ear with F(mean) = 1-6.4 kHz. Surprisingly, the hearing phenotypes did not naturally separate into discrete classes of presbycusis. Principal component (PC) analysis revealed that two principal components account for 74% of the variance among the 30 measures of hearing. The two components represent the overall degree (PC1) and configuration of loss (Flat vs. Sloping; PC2) and the phenotypes form a continuum when plotted against them. A heuristic partitioning of this continuum produced classes of presbycusis that vary in their degree of Sloping or Flat hearing loss, suggesting that the previously reported sub-types of presbycusis arise from the categorical segregation of a continuous and heterogeneous distribution. Further, most phenotypes lie intermediate to the extremes of either Flat or Sloping loss, indicating that if audiometric configuration does predict presbycusis etiology, then a mixed origin is the most prevalent. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Allen, Paul D.] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
[Eddins, David A.] Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
[Eddins, David A.] Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
RP Allen, PD (reprint author), Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, 601 Elmwood Ave,Box 603, Rochester, NY 14642 USA.
EM paul_allen@urmc.rochester.edu; david_eddins@urmc.rochester.edu
FU USPHS [AG009524, DC005409]
FX We thank Prof. James R. Ison for helpful conversations and comments on
this manuscript and two anonymous reviewers for their insightful
critiques. This research was supported by USPHS Grants AG009524 and
DC005409. Portions of this work were previously presented at the 32nd
Annual Midwinter Research Meeting of the Association for Research in
Otolaryngology, February 14-19 2009.
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NR 38
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 10
EP 20
DI 10.1016/j.heares.2010.02.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100003
PM 20144701
ER
PT J
AU Harris, KC
Eckert, MA
Ahlstrom, JB
Dubno, JR
AF Harris, Kelly C.
Eckert, Mark A.
Ahlstrom, Jayne B.
Dubno, Judy R.
TI Age-related differences in gap detection: Effects of task difficulty and
cognitive ability
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Auditory temporal processing; Gap detection; Processing speed;
Workload; Cognitive
ID CORTICAL EVOKED-POTENTIALS; DOWN SUPPRESSION DEFICIT;
MENTAL-STATE-EXAMINATION; HEARING-LOSS; DURATION DISCRIMINATION; SPEECH
RECOGNITION; TEMPORAL GAPS; OLDER-ADULTS; INTENSITY DISCRIMINATION;
INFERIOR COLLICULUS
AB Differences in gap detection for younger and older adults have been shown to vary with the complexity of the task or stimuli, but the factors that contribute to these differences remain unknown. To address this question, we examined the extent to which age-related differences in processing speed and workload predicted age-related differences in gap detection. Gap detection thresholds were measured for 10 younger and 11 older adults in two conditions that varied in task complexity but used identical stimuli: (1) gap location fixed at the beginning, middle, or end of a noise burst and (2) gap location varied randomly from trial to trial from the beginning, middle, or end of the noise. We hypothesized that gap location uncertainty would place increased demands on cognitive and attentional resources and result in significantly higher gap detection thresholds for older but not younger adults. Overall, gap detection thresholds were lower for the middle location as compared to beginning and end locations and were lower for the fixed than the random condition. In general, larger age-related differences in gap detection were observed for more challenging conditions. That is, gap detection thresholds for older adults were significantly larger for the random condition than for the fixed condition when the gap was at the beginning and end locations but not the middle. In contrast, gap detection thresholds for younger adults were not significantly different for the random and fixed condition at any location. Subjective ratings of workload indicated that older adults found the gap detection task more mentally demanding than younger adults. Consistent with these findings, results of the Purdue Pegboard and Connections tests revealed age-related slowing of processing speed. Moreover, age group differences in workload and processing speed predicted gap detection in younger and older adults when gap location varied from trial to trial; these associations were not observed when gap location remained constant across trials. Taken together, these results suggest that age-related differences in complex measures of auditory temporal processing may be explained, in part, by age-related deficits in processing speed and attention. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Harris, Kelly C.; Eckert, Mark A.; Ahlstrom, Jayne B.; Dubno, Judy R.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Harris, KC (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA.
EM harriskc@musc.edu
FU NIDCD [P50 DC00422, K23 DC008787]; National Center for Research
Resources, National Institutes of Health [C06 RR14516]
FX We thank the participants of this study and Ning-Ji He for her
assistance with stimulus generation. This work was supported (in part)
by grants from the NIDCD (P50 DC00422 and K23 DC008787). This
investigation was conducted in a facility constructed with support from
Research Facilities Improvement Program Grant Number C06 RR14516 from
the National Center for Research Resources, National Institutes of
Health.
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NR 70
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 21
EP 29
DI 10.1016/j.heares.2009.09.017
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100004
PM 19800958
ER
PT J
AU Humes, LE
Kewley-Port, D
Fogerty, D
Kinney, D
AF Humes, Larry E.
Kewley-Port, Diane
Fogerty, Daniel
Kinney, Dana
TI Measures of hearing threshold and temporal processing across the adult
lifespan
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Hearing loss; Temporal processing; Individual differences
ID AGE-RELATED DIFFERENCES; GAP DETECTION; BACKWARD-MASKING; ELDERLY
LISTENERS; AUDITORY-SYSTEM; OLDER-ADULTS; RECOGNITION; DISCRIMINATION;
YOUNGER; SPEECH
AB Psychophysical data on hearing sensitivity and various measures of supra-threshold auditory temporal processing are presented for large groups of young (18-35 y), middle-aged (40-55 y) and older (6089 y) adults. Hearing thresholds were measured at 500,1414 and 4000 Hz. Measures of temporal processing included gap-detection thresholds for bands of noise centered at 1000 and 3500 Hz, stimulus onset asynchronies for monaural and dichotic temporal-order identification for brief vowels, and stimulus onset/offset asynchronies for the monaural temporal masking of vowel identification. For all temporal-processing measures, the impact of high-frequency hearing loss in older adults was minimized by a combination of low-pass filtering the stimuli and use of high presentation levels. The performance of the older adults was worse than that of the young adults on all measures except gap-detection threshold at 1000 Hz. Middle-aged adults performed significantly worse than the young adults on measures of threshold sensitivity and three of the four measures of temporal-order identification, but not for any of the measures of temporal masking. Individual differences are also examined among a group of 124 older adults. Cognition and age were found to be significant predictors, although only 10-27% of the variance could be accounted for by these predictors. (C) 2009 Published by Elsevier B.V.
C1 [Humes, Larry E.; Kewley-Port, Diane; Fogerty, Daniel; Kinney, Dana] Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA.
RP Humes, LE (reprint author), Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA.
EM humes@indiana.edu
FU National Institute on Aging [R01 AG022334]
FX The authors thank Leah Barlow, Devan Haulk, Liz Moller, Kate Wagner and
Xin Wang for their assistance with data collection and Bill Mills and
Noah Silbert for their assistance with MATLAB programming. We also thank
the hundreds of participants for giving so generously of their time.
This work was supported, in part, by a research grant from the National
Institute on Aging (R01 AG022334).
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NR 43
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 30
EP 40
DI 10.1016/j.heares.2009.09.010
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100005
PM 19786083
ER
PT J
AU Fitzgibbons, PJ
Gordon-Salant, S
AF Fitzgibbons, Peter J.
Gordon-Salant, Sandra
TI Age-related differences in discrimination of temporal intervals in
accented tone sequences
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Temporal discrimination; Tone sequences; Accent
ID GAP DETECTION; DURATION DISCRIMINATION; AUDITORY SEQUENCES; SPEECH;
LISTENERS; THRESHOLDS; PATTERNS; YOUNGER; ADULTS; NOISE
AB The study measured listener sensitivity to increments of a target inter-onset interval (101) embedded within isochronous tone sequences that featured a single accented tonal component. The sequences consisted of six 1000-Hz tone bursts separated by silent intervals to establish equal tonal 101s of 200 ms within the sequence. Tone burst durations within the sequences were 50 ms, except one tone had a longer duration of 100 ms to produce a perception of accent. Duration DLs in ms for increments of a single sequence 101 were measured adaptively by adjusting the duration of the silent interval between two tones. Sequence position of the target 101 differed across conditions. Listeners included young normal-hearing adults and older adults with and without hearing loss. Discrimination performance of the two older listener groups was equivalent and significantly poorer than that of the younger listeners in each discrimination condition. The age-related discrimination deficits were independent of sequence locations of both the target interval and the accented tonal component. Comparative DLs collected for target intervals in unaccented tone sequences with equal tone durations revealed that the detrimental effects of accent on temporal discrimination were primarily restricted to the older listeners. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Fitzgibbons, Peter J.] Gallaudet Univ, Dept Hearing Speech & Language Sci, Washington, DC 20002 USA.
[Gordon-Salant, Sandra] Univ Maryland, Dept Hearing & Speech Sci, Dept Speech & Hearing Sci, College Pk, MD 20742 USA.
RP Fitzgibbons, PJ (reprint author), Gallaudet Univ, Dept Hearing Speech & Language Sci, Washington, DC 20002 USA.
EM peter.fitzgibbons@gallaudet.edu
FU National Institute Aging [R37AG09191]
FX This research was supported by Grant R37AG09191 from the National
Institute Aging. The authors are grateful to Helen Hwang and Keena James
for their assistance in data collection and analysis.
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NR 24
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 41
EP 47
DI 10.1016/j.heares.2009.11.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100006
PM 19931608
ER
PT J
AU Clinard, CG
Tremblay, KL
Krishnan, AR
AF Clinard, Christopher G.
Tremblay, Kelly L.
Krishnan, Ananthanarayan R.
TI Aging alters the perception and physiological representation of
frequency: Evidence from human frequency-following response recordings
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Frequency discrimination; Frequency-following response; FFR;
Auditory evoked potentials; Auditory brainstem
ID BRAIN-STEM RESPONSES; ENVELOPE-FOLLOWING RESPONSES; HEARING-IMPAIRED
LISTENERS; AUDITORY-EVOKED-POTENTIALS; TEMPORAL FINE-STRUCTURE;
STEADY-STATE RESPONSES; AGE-RELATED-CHANGES; NEURAL REPRESENTATION;
OLDER LISTENERS; INTENSITY DISCRIMINATION
AB Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiological measures of frequency representation. Thirty two adults (ages 22-77), with hearing thresholds <= 25 dB HL at octave frequencies 0.25-8.0 kHz, participated in this experiment. Frequency discrimination difference limens (FDLs) were obtained at 500 and 1000 Hz using a two-interval, two-alternative forced choice procedure. Linear regression analyses showed significant declines in FDLs at both frequencies as age increased. Frequency-following responses (FFRs) were elicited by 500 and 1000 Hz tonebursts, as well as at frequencies within and outside those FDLs. Linear regression of FFR phase coherence and FFR amplitude at frequencies at and slightly below 1000 Hz showed significant decreases as age increased. Therefore, pitch discrimination, as measured by FDLs, and neural representation of frequency, as reflected by FFR, declined as age increased. Although perception and neural representation concurrently declined, one was not predictive of the other. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Clinard, Christopher G.; Tremblay, Kelly L.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA.
[Krishnan, Ananthanarayan R.] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA.
RP Clinard, CG (reprint author), Univ Washington, Dept Speech & Hearing Sci, 1417 NE 42nd St,Box 354875, Seattle, WA 98105 USA.
EM cclinard@uw.edu; tremblay@uw.edu
FU National Institutes of Health [R01-DC007705, T32-DC00033, P30-DC04661,
R01 DC008549]; UW Virginia Merrill Bloedel Scholar Program
FX This work was supported by the National Institutes of Health
R01-DC007705 (KT), T32-DC00033 (CC), P30-DC04661, and R01 DC008549
(ARK). Funding for KT from the UW Virginia Merrill Bloedel Scholar
Program is also acknowledged. Thanks to Sasha John, Terry Picton, and G.
Christopher Stecker for their programming assistance, as well as Jordan
Cannon for his assistance with data collection.
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NR 68
TC 39
Z9 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 48
EP 55
DI 10.1016/j.heares.2009.11.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100007
PM 19944140
ER
PT J
AU Sommers, MS
Gehr, SE
AF Sommers, Mitchell S.
Gehr, Sara E.
TI Two-tone auditory suppression in younger and older normal-hearing adults
and its relationship to speech perception in noise
SO HEARING RESEARCH
LA English
DT Article
DE Auditory suppression; Speech perception in noise; Aging
ID GAP DETECTION; DURATION DISCRIMINATION; PSYCHOPHYSICAL MEASURES;
FREQUENCY-SELECTIVITY; SIMULTANEOUS MASKING; AGE; STIMULI; EXCITATION;
LISTENERS; CONTEXT
AB One approach for establishing how age affects psychoacoustic abilities is to compare the performance of young and older adults with normal auditory sensitivity. The present study used this approach to determine if age affects two-tone suppression - a reduction in masked thresholds (henceforth, unmasking) following the introduction of a second (suppressing) tone to a masker-plus-signal stimulus complex. A secondary goal of the study was to assess whether individual differences in suppression would predict identification scores for words presented in a forward masking noise. Unmasking was measured by comparing forward-masked thresholds for a 2000 Hz signal with a tonal (2000 Hz) masker alone or the tonal masker plus a 2300 Hz tonal suppressor. Speech perception in noise was assessed by obtaining forward-masked speech reception thresholds (SRTs) for isolated words presented with speech-shaped noise. Young, but not older, normal-hearing adults exhibited significant amounts of unmasking. Nineteen of the 20 young adults tested exhibited unmasking, whereas less that half of the 25 older participants exhibited any unmasking. The correlation between suppression as indexed by unmasking and SRTs in young adults was approximately -0.6, suggesting that more suppression was associated with lower SRTs. The findings suggest that auditory suppression is one of the few psychoacoustic abilities that demonstrate significant changes with age even for older adults with minimal hearing loss. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sommers, Mitchell S.; Gehr, Sara E.] Washington Univ, Dept Psychol, St Louis, MO 63130 USA.
RP Sommers, MS (reprint author), Washington Univ, Dept Psychol, Campus Box 1125, St Louis, MO 63130 USA.
EM MSommers@wustl.edu
FU National Institute for Aging [R03 AG033009-01]; Brookdale Foundation
FX The authors would like to thank Stephanie Danielson and Adam Weinberg
for assistance with data collection. Portions of these data were
collected as part of the second author's Doctoral Dissertation. Support
for the research was provided by the National Institute for Aging (R03
AG033009-01) and by the Brookdale Foundation.
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NR 39
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 56
EP 62
DI 10.1016/j.heares.2009.12.020
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100008
PM 20006694
ER
PT J
AU Walton, JP
AF Walton, Joseph P.
TI Timing is everything: Temporal processing deficits in the aged auditory
brainstem
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Temporal resolution; Neural correlates; Animal models
ID DORSAL COCHLEAR NUCLEUS; RAT INFERIOR COLLICULUS; AMPLITUDE-MODULATED
SOUNDS; MEDIAL GENICULATE-NUCLEUS; GAP DETECTION; HEARING-LOSS; SPEECH
RECOGNITION; ELDERLY LISTENERS; RECEPTOR-BINDING; NERVE FIBERS
AB This summary article reviews the literature on neural correlates of age-related changes in temporal processing in the auditory brainstem. Two types of temporal processing dimensions are considered, (i) static, which can be measured using a gap detection or forward masking paradigms, and (ii) dynamic, which can be measured using amplitude and frequency modulation. Corresponding data from physiological studies comparing neural responses from young and old animals using acoustic stimuli as silent gaps-in-noise, amplitude modulation, and frequency modulation are considered in relation to speech perception. Evidence from numerous investigations indicates an age-related decline in encoding of temporal sound features which may be a contributing factor to the deficits observed in speech recognition in many elderly listeners. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Walton, Joseph P.] Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
[Walton, Joseph P.] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
RP Walton, JP (reprint author), Univ Rochester, Sch Med & Dent, Dept Otolaryngol, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM joseph_walton@URMC.rochester.edu
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NR 61
TC 29
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 63
EP 69
DI 10.1016/j.heares.2010.03.002
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100009
PM 20303402
ER
PT J
AU Syka, J
AF Syka, Josef
TI The Fischer 344 rat as a model of presbycusis
SO HEARING RESEARCH
LA English
DT Article
DE Rat; Fischer 344; Presbycusis; Aging; Model
ID AGE-RELATED-CHANGES; CENTRAL AUDITORY-SYSTEM; GLUTAMIC-ACID
DECARBOXYLASE; CONTRALATERAL MONAURAL STIMULI; INFERIOR COLLICULUS
RESPONSES; RECEPTOR SUBUNIT COMPOSITION; CNS STRUCTURAL ELEMENTS;
BRAIN-STEM RESPONSES; OUTER HAIR CELL; COCHLEAR-NUCLEUS
AB Due to the rising number of the aged human population all over the world, presbycusis is a phenomenon that deserves the increasing attention of the medical community as regards to prevention and treatment. This requires finding appropriate animal models for human presbycusis that will be useful in future experiments. Among the available rat strains, the Fischer 344 (F344) strain promises to serve as a model producing prompt and profound presbycusis. Hearing thresholds begin to increase in this strain during the first year of life; toward the end of the second year, the thresholds are very high. The threshold shifts progress independently in both ears. The rapid deterioration of distortion product otoacoustic emissions, with the majority of outer hair cells (OHC) being present and morphologically intact, is apparently produced by the disruption of prestin. The age-related changes within inner ear function are accompanied by deterioration of acoustical signal processing within central auditory system, mainly due to impaired GABA inhibition. The loss of GABA inhibition in old animals is expressed primarily in the inferior colliculus but is also present in the cochlear nuclei and the auditory cortex. Sound-evoked behavioral reactions are also impaired in old F344 rats. Taken together, the described characteristics of the aging F344 rat auditory system supports the idea that this strain may serve as a suitable model for studying the mechanisms of presbycusis, its prevention and treatment. (C) 2009 Elsevier B.V. All rights reserved.
C1 Acad Sci Czech Republic, Inst Expt Med, Prague 14220, Czech Republic.
RP Syka, J (reprint author), Acad Sci Czech Republic, Inst Expt Med, Prague 14220, Czech Republic.
EM syka@biomed.cas.cz
RI Syka, Josef/H-3103-2014
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NR 56
TC 26
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 70
EP 78
DI 10.1016/j.heares.2009.11.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100010
PM 19903514
ER
PT J
AU Hughes, LF
Turner, JG
Parrish, JL
Caspary, DM
AF Hughes, Larry F.
Turner, Jeremy G.
Parrish, Jennifer L.
Caspary, Donald M.
TI Processing of broadband stimuli across A1 layers in young and aged rats
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Inhibition; Noise; Rats; Auditory cortex; Auditory; Cortex; Age;
Physiology; Broadband noise; Response properties; GABA
ID PRIMARY AUDITORY-CORTEX; INFERIOR COLLICULUS NEURONS; VISUAL
CORTICAL-CELLS; GABAERGIC INHIBITION; RECEPTIVE-FIELDS; SPEECH
RECOGNITION; HEARING IMPAIRMENT; MONGOLIAN GERBIL; COCHLEAR NUCLEUS;
SINGLE NEURONS
AB Presbycusis can be considered a slow age-related peripheral and central deterioration of auditory function which manifests itself as deficits in speech comprehension, especially in noisy environments. The present study examined neural correlates of a simple broadband noise stimulus in primary auditory cortex (A1) of young and aged Fischer-Brown Norway (FBN) rats. Age-related changes in unit responses to broadband noise bursts and spontaneous activity were simultaneously recorded across A1 layers using a single shank, 16-channel electrode. Noise bursts were presented contralateral to the left A1 at 80 dB SPL. Aged A1 units displayed increased spontaneous (29%), peak (24%), and steady state response rates (38%) than did young A1 units. This was true across all A1 layers, although age-related differences were significantly greater for layers I-Ill (43% vs 18%) than lower layers. There was a significant age-related difference in the depth and duration of post-onset suppression between young and aged upper layer A1 units. The present functional differences across layers were consistent with studies showing greatest losses of gamma-aminobutyric acid (GABA) markers in superficial layers of A1 and with anatomic studies showing highest levels of inhibitory neurons located in superficial cortical layers. The present findings were also consistent with aging studies suggesting loss of functional inhibition in other cortical sensory systems. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Hughes, Larry F.; Turner, Jeremy G.; Parrish, Jennifer L.] So Illinois Univ, Sch Med, Dept Surg, Div Otolaryngol, Springfield, IL 62794 USA.
[Turner, Jeremy G.] Illinois Coll, Dept Psychol, Jacksonville, IL USA.
[Caspary, Donald M.] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA.
RP Hughes, LF (reprint author), So Illinois Univ, Sch Med, Dept Surg, Div Otolaryngol, Springfield, IL 62794 USA.
EM lhughes@siumed.edu
FU SIU Excellence in Academic Medicine [NIH DC00151, NIH AG023910]
FX Supported in part by Grants (SIU Excellence in Academic Medicine grant
to L.F.H., NIH DC00151 to D.M.C., NIH AG023910 to J.G.T.). The authors
wish to express their sincere thanks to Loren Zuiderveld and Andrew K.
James for their help with spike sorting.
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NR 70
TC 21
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 79
EP 85
DI 10.1016/j.heares.2009.09.005
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100011
PM 19772906
ER
PT J
AU Sha, SH
Chen, FQ
Schacht, J
AF Sha, Su-Hua
Chen, Fu-Quan
Schacht, Jochen
TI PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J
mouse
SO HEARING RESEARCH
LA English
DT Article
DE Outer hair cells; PTEN; PIP3; Akt; Aging cochlea
ID INNER-EAR; APOPTOSIS; PATHWAY; INHIBITION; ACTIVATION; PROTEIN;
PHOSPHATASE; EXPRESSION; INSIGHTS; PKB/AKT
AB We have previously reported the activation of cell death pathways in the sensory cells of the aging cochlea. Here we investigate age-associated changes in survival mechanisms focusing on phosphatidylinositol 3,4,5-trisphosphate (PIP3)/Akt signaling. The animal model is the CBA/J mouse of 18 months of age prior to the onset of major functional loss (ABR thresholds, 26 +/- 8 dB SPL) which is compared to young animals of 3 months of age (ABR thresholds, 19 +/- 7 dB SPL). Immunostaining on cochlear cryosections revealed a wide-spread distribution of PIP3 in the cochlea which was markedly attenuated in old animals in inner and outer hair cells, Deiters cells and pillar cells. Protein levels of the lipid phosphatase PTEN which regulates PIP3 increased in those cells with aging while its mRNA did not, suggesting an age-related reduction of PTEN degradation. Furthermore, staining intensity of phosphorylated PTEN (ser380) and its nuclear localization increased. Consistent with a reduction of PIP3, the phosphorylation of the downstream target Akt at threonine 308 significantly decreased in outer hair cells. The results suggest a decline of the survival capacity of aging outer hair cells due to a decrease in PIP3/Akt signaling caused by an increase of PTEN. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sha, Su-Hua; Chen, Fu-Quan; Schacht, Jochen] Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Chen, Fu-Quan] Fourth Mil Med Univ, Dept Otolaryngol, Xian 710032, Peoples R China.
RP Sha, SH (reprint author), Univ Michigan, Kresge Hearing Res Inst, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM shasha@umich.edu
FU National Institute of Aging [AG-025164]; National Institute on Deafness
and Other Communication Disorders, NIH [P30 DC-05188]
FX This study was supported by program project Grant AG-025164 from the
National Institute of Aging and core Grant P30 DC-05188 from the
National Institute on Deafness and Other Communication Disorders, NIH.
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NR 33
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 86
EP 92
DI 10.1016/j.heares.2009.09.002
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100012
PM 19761823
ER
PT J
AU Bao, JX
Ohlemiller, KK
AF Bao, Jianxin
Ohlemiller, Kevin K.
TI Age-related loss of spiral ganglion neurons
SO HEARING RESEARCH
LA English
DT Article
DE Spiral ganglion neuron; Hair cell; Neural presbycusis; Aging;
Glucocorticoid; Caloric restriction; Calcium
ID HAIR CELL LOSS; DIETARY RESTRICTION; HEARING-LOSS; INNER-EAR; LIFE-SPAN;
COCHLEAR DEGENERATION; MITOCHONDRIAL-DNA; MICE LACKING; C-ELEGANS;
SUPEROXIDE-DISMUTASE
AB Spiral ganglion neurons (SGNs) are the relay station for auditory information between hair cells and central nervous system. Age-related decline of auditory function due to SGN loss can not be ameliorated by hearing aids or cochlear implants. Recent findings clearly indicate that survival of SGNs during aging depends on genetic and environmental interactions, which can be demonstrated at the systemic, tissue, cellular, and molecular levels. At the systemic level, both insulin/insulin-like growth factor-1 and lipophilic/steroid hormone pathways influence SGN survival during aging. At the level of organ of the Corti, it is difficult to determine whether age-related SGN loss is primary or secondary degeneration. However, a late stage of SGN degeneration may be independent of age-related loss of hair cells. At the cellular and molecular level, several pathways, particularly free radical and calcium signaling pathways, can influence age-related SGN loss, and further studies should determine how these pathways contribute to SGN loss, such as whether they directly or indirectly act on SGNs. With the advancement of recent genetic and pharmacologic tools, we should not only understand how SGNs die during aging, but also find ways to delay this loss. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bao, Jianxin; Ohlemiller, Kevin K.] Washington Univ, Sch Med, Dept Otolaryngol, Fay & Carl Simmons Ctr Biol Hearing & Deafness, St Louis, MO 63110 USA.
RP Bao, JX (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, Ctr Aging, POB 8115,660 S Euclid Ave, St Louis, MO 63110 USA.
EM jbao@wustl.edu
FU National Organization for Hearing Research Foundation [NIH R21 DC010489,
NIH R01 AG024250, R01 DC008321, P30 DC04665]
FX We would like thank Ms. Joyce Ji for comments on the manuscript.
Supported by the National Organization for Hearing Research Foundation
(J.B.), NIH R21 DC010489 (J.B.), NIH R01 AG024250 (J.B.), R01 DC008321
(K.K.O.), and P30 DC04665 (R. Chole).
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NR 97
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 93
EP 97
DI 10.1016/j.heares.2009.10.009
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100013
PM 19854255
ER
PT J
AU Bielefeld, EC
Tanaka, C
Chen, GD
Henderson, D
AF Bielefeld, Eric C.
Tanaka, Chiemi
Chen, Guang-di
Henderson, Donald
TI Age-related hearing loss: Is it a preventable condition?
SO HEARING RESEARCH
LA English
DT Article
DE Presbycusis; Fischer 344 rat; Age-related hearing loss; Antioxidant
ID AUGMENTED ACOUSTIC ENVIRONMENT; ANTEROVENTRAL COCHLEAR NUCLEUS; EXPOSING
DBA/2J MICE; ACETYL-L-CYSTEINE; AGING INNER-EAR; HAIR CELL LOSS; CALORIE
RESTRICTION; DIETARY RESTRICTION; C57BL/6J MICE; SUPEROXIDE-DISMUTASE
AB Numerous techniques have been tested to attempt to prevent the onset or progression of age-related hearing loss (ARHL): raising the animals in an augmented acoustic environment (used successfully in mouse and rat models), enhancing the antioxidant defenses with exogenous antioxidant treatments (used with mixed results in mouse and rat models), raising the animals with a calorie restricted diet (used successfully in mouse and rat models), restoring lost endocochlear potential voltage with exogenous electrical stimulation (used successfully in the Mongolian gerbil model), and hypothetical enhancement of outer hair cell electromotility with salicylate therapy. Studies of human ARHL have revealed a set of unique hearing loss configurations with unique underlying pathologies. Animal research has developed models for the different forms of age-related peripheral pathology. Using the animal models, different techniques for prevention of ARHL have been developed and tested. The current review discusses ARHL patterns in humans and animal models, followed by discussions of the different prevention techniques. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bielefeld, Eric C.; Tanaka, Chiemi; Chen, Guang-di; Henderson, Donald] SUNY Buffalo, Ctr Hearing & Deafness, Dept Commun Disorders & Sci, Buffalo, NY 14214 USA.
RP Bielefeld, EC (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, Dept Commun Disorders & Sci, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM ecb2@buffalo.edu
RI Bielefeld, Eric/D-2015-2012
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NR 106
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 1
PY 2010
VL 264
IS 1-2
SI SI
BP 98
EP 107
DI 10.1016/j.heares.2009.09.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 609YG
UT WOS:000278694100014
PM 19735708
ER
PT J
AU Manley, GA
AF Manley, Geoffrey A.
TI An evolutionary perspective on middle ears
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle ear; Evolution; Ossicles; Columella; Stapes; Tympanum; Sound
localization; Hearing; Tympanic middle ear; Amniote audition
ID ECHIDNA TACHYGLOSSUS-ACULEATUS; INNER-EAR; TETRAPOD; HEARING;
VERTEBRATES; AFFINITIES; PERCEPTION; MONOTREME; FISH
AB The traditional view that a tympanic middle ear developed only once, when vertebrates made the transition from fish in water to land-living animals, has been shown to be incorrect. Middle ears with a tympanum connected by one or more ossicles to the cochlea developed very much later in evolutionary history and independently in many amniote vertebrate lineages - most now extinct. The mammalian middle ear is unique but it is not simply an "improved" single-ossicle middle ear. It is a radical and fortuitous new development that owes its origin more to changes in feeding patterns than to hearing. It happened to transmit higher-frequency sounds better than single-ossicle middle ears and enabled the evolution of the high upper-frequency hearing limits of most mammals. Parallel to the development of a tympanic middle ear in therian mammals, the brain increased in size and a secondary palate developed, resulting in the ancestral pressure-gradient middle ear being replaced by a purely pressure system. Sound localization then became almost completely dependent on neural computation and this was the most important factor driving up the upper frequency limits of early mammals. This paper presents an historical perspective on these remarkably simple and yet highly effective structures. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Manley, Geoffrey A.] Tech Univ Munich, Lehrstuhl Zool, D-85350 Freising Weihenstephan, Germany.
[Manley, Geoffrey A.] Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia.
RP Manley, GA (reprint author), Tech Univ Munich, Lehrstuhl Zool, Hochfeldweg 2, D-85350 Freising Weihenstephan, Germany.
EM Geoffrey.manley@wzw.tum.de
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NR 38
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 3
EP 8
DI 10.1016/j.heares.2009.09.004
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700002
PM 19786082
ER
PT J
AU de La Rochefoucauld, O
Olson, ES
AF de La Rochefoucauld, Ombeline
Olson, Elizabeth S.
TI A sum of simple and complex motions on the eardrum and manubrium in
gerbil
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Motion; Manubrium; Tympanic membrane; Gerbil; Middle ear
ID TYMPANIC-MEMBRANE VIBRATIONS; TIME-AVERAGED HOLOGRAPHY; FINITE-ELEMENT
MODEL; MIDDLE-EAR; FREQUENCY-RESPONSE; MALLEUS VIBRATION; SOUND
CONDUCTION; CAT EARDRUM; IMPEDANCE
AB Based on comparisons of ear canal and scala vestibuli pressures the gerbil middle ear transmits sound with a gain of similar to 25 dB that is almost flat from 2 to 40 kHz, and with a delay-like phase corresponding to a 25-30 mu s delay. How the middle ear is able to transmit sound with such high temporal and amplitude fidelity is not known, and is particularly mysterious given the complex motion the ossicles and tympanic membrane (TM) are known to undergo. To explore this question, we looked at the velocities of the manubrium and along a line on the TM. The TM motion was complex, and could be approximated as the combination of a wave-like motion and an in-and-out piston-like motion. The manubrium underwent bending at some stimulus frequencies and therefore its motion was not like a rigid body. It had a complex motion with frequency fine structure that seemed likely to be derived from resonances on the drum-like TM. (C) 2009 Elsevier B.V. All rights reserved.
C1 [de La Rochefoucauld, Ombeline] Columbia Univ, Dept Otolaryngol Head & Neck Surg, New York, NY 10032 USA.
[Olson, Elizabeth S.] Columbia Univ, Dept Otolaryngol, New York, NY 10032 USA.
[Olson, Elizabeth S.] Columbia Univ, Dept Head & Neck Surg, New York, NY 10032 USA.
[Olson, Elizabeth S.] Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA.
RP de La Rochefoucauld, O (reprint author), Columbia Univ, Dept Otolaryngol Head & Neck Surg, 630 W 168th St, New York, NY 10032 USA.
EM odelarochefoucauld@gmail.com; eao2004@columbia.edu
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NR 29
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 9
EP 15
DI 10.1016/j.heares.2009.10.014
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700003
PM 19878713
ER
PT J
AU Ravicz, ME
Slama, MCC
Rosowski, JJ
AF Ravicz, Michael E.
Slama, Michael C. C.
Rosowski, John J.
TI Middle-ear pressure gain and cochlear partition differential pressure in
chinchilla
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle-ear sound transmission; Intracochlear sound pressure; Middle-ear
gain; Cochlear impedance; Chinchilla
ID STAPES VELOCITY; SOUND; TRANSMISSION; GERBIL; CAT; ADMITTANCE;
MECHANICS; MEMBRANE; HEARING; BASE
AB An important step to describe the effects of inner-ear impedance and pathologies on middle- and inner-ear mechanics is to quantify middle- and inner-ear function in the normal ear. We present middle-ear pressure gain G(MEP) and trans-cochlear-partition differential sound pressure Delta P(CP) in chinchilla from 100 Hz to 30 kHz derived from measurements of intracochlear sound pressures in scala vestibuli P(SV) and scala tympani P(ST) and ear-canal sound pressure near the tympanic membrane P(TM). These measurements span the chinchilla's auditory range. G(MEP) had constant magnitude of about 20 dB between 300 Hz and 20 kHz and phase that implies a 40-mu s delay, values with some similarities to previous measurements in chinchilla and other species. Delta P(CP) was similar to G(MEP) below about 10 kHz and lower in magnitude at higher frequencies, decreasing to 0 dB at 20 kHz. The high-frequency rolloff correlates with the audiogram and supports the idea that middle-ear transmission limits high-frequency hearing, providing a stronger link between inner-ear macromechanics and hearing. We estimate the cochlear partition impedance Z(CP). from these and previous data. The chinchilla may be a useful animal model for exploring the effects of non-acoustic inner-ear stimulation such as "bone conduction" on cochlear mechanics. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ravicz, Michael E.; Slama, Michael C. C.; Rosowski, John J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Dept Otolaryngol, Boston, MA 02114 USA.
[Ravicz, Michael E.; Rosowski, John J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Slama, Michael C. C.; Rosowski, John J.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
RP Ravicz, ME (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
EM Mike_Ravicz@meei.harvard.edu
CR Beranek L.L., 1986, ACOUSTICS
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NR 37
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 16
EP 25
DI 10.1016/j.heares.2009.11.014
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700004
PM 19945521
ER
PT J
AU Aerts, JRM
Dirckx, JJJ
AF Aerts, J. R. M.
Dirckx, J. J. J.
TI Nonlinearity in eardrum vibration as a function of frequency and sound
pressure
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle ear; Nonlinear distortions; Heterodyne vibrometry
ID HUMAN TYMPANIC MEMBRANE; HUMAN MIDDLE-EAR; STATIC PRESSURE;
DISPLACEMENT; DEFORMATION; EMISSIONS; GERBIL; SYSTEM
AB It is generally accepted that the middle ear acts mainly as a linear system for sound pressures up to 130 dB SPL in the auditory frequency range. However, at quasi-static pressure loads a strong nonlinear response has been demonstrated. Consequently, small nonlinear distortions may also be present in the middle ear response in the auditory frequency range. A new measurement method was developed to quickly determine vibration response, nonlinear distortions and noise level of acoustically driven biomechanical systems. Specially designed multisines are used for the excitation of the test system. The method is applied on a gerbil eardrum for sound pressures ranging from 90 to 120 dB SPL and for frequencies ranging from 125 Hz to 16 kHz. The experiments show that nonlinear distortions rise above noise level at a sound pressure of 96 dB SPL, and they grow as sound pressure increases. Post-mortem changes in the middle ear influence the nonlinear distortions rapidly until a stabilization occurs after approximately 3 h. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Aerts, J. R. M.; Dirckx, J. J. J.] Univ Antwerp, Lab BioMed Phys, B-2020 Antwerp, Belgium.
RP Aerts, JRM (reprint author), Univ Antwerp, Lab BioMed Phys, B-2020 Antwerp, Belgium.
EM johan.aerts@ua.ac.be; joris.dirckx@ua.ac.be
RI Aerts, Johan/E-9259-2010
CR AERTS J, 2008, MEASUREMENT SCI TECH, V19, P10
Aerts JRM, 2007, MEAS SCI TECHNOL, V18, P3344, DOI 10.1088/0957-0233/18/11/013
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DIRCKX JJJ, 1991, HEARING RES, V51, P93, DOI 10.1016/0378-5955(91)90009-X
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NR 15
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 26
EP 32
DI 10.1016/j.heares.2009.12.022
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700005
PM 20026266
ER
PT J
AU Soons, JAM
Aernouts, J
Dirckx, JJJ
AF Soons, Joris A. M.
Aernouts, Jef
Dirckx, Joris J. J.
TI Elasticity modulus of rabbit middle ear ossicles determined by a novel
micro-indentation technique
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE ME ossicles; Micro-indentation; Biomechanics; Young's modulus; FE
modelling
ID FINITE-ELEMENT-METHOD; EARDRUM; DISPLACEMENT; FREQUENCY; PRESSURE
AB For the purpose of creating a finite element model of the middle ear, the ossicles can be modelled as rigid bodies or as linear elastic materials. The general elasticity parameters used are usually measured on lager bones like the femur. In order to obtain a highly realistic model, the actual elastic modulus (Young's modulus) of the ossicles themselves is needed. We developed a novel 2-needle indentation method of determining the Young's modulus of small samples based on Sneddon's solution. We introduce the second needle in such a way that small specimens can be clamped between the two needles and a symmetry plane is obtained, so that geometry-dependent sample deformations are avoided. A finite element calculated correction factor is used to compensate for the small thickness of the samples. The system was tested on several materials with known parameters in order to validate the technique, and was then used to determine the elasticity parameters of incus and malleus in rabbit. No significant differences between measurement locations were found, and we found an average Young's modulus of 16 +/- 3 GPa. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Soons, Joris A. M.; Aernouts, Jef; Dirckx, Joris J. J.] Univ Antwerp, Lab Biomed Phys, B-2020 Antwerp, Belgium.
RP Soons, JAM (reprint author), Univ Antwerp, Lab Biomed Phys, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
EM joris.soons@ua.ac.be
RI Soons, Joris/G-1552-2010
CR [Anonymous], 2008, ANN BOOK ASTM STAND
BUYTAERT JAN, 2009, MEMRO 2009 M
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Dirckx JJJ, 2001, HEARING RES, V157, P124, DOI 10.1016/S0378-5955(01)00290-8
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NR 24
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 33
EP 37
DI 10.1016/j.heares.2009.10.001
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700006
PM 19818840
ER
PT J
AU Sim, JH
Chatzimichalis, M
Huber, AM
AF Sim, Jae Hoon
Chatzimichalis, Michail
Huber, Alexander M.
TI The influence of postoperative tissue formation on sound transmission
after stapes surgery
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Air-bone gap (ABG); Incus; Laser Doppler interferometry (LDI); Mucosa;
Mucosa ongrowth; Otosclerosis; Prosthesis; Revision; Sound transmission
loss (STL); Stapes; Stapes surgery
ID OTOSCLEROSIS SURGERY
AB In the surgical treatment of otosclerosis, the coupling between the stapes prosthesis and the long process of the incus is critical. After surgery, connective tissue and mucosa may grow over the coupling area and thereby influence the sound transmission properties of the incus-prosthesis interface.
It was the hypothesis of this study that tissue ongrowth in the incus-prosthesis interface has little influence on sound transmission following stapes surgery. The goals of the study were to: (1) investigate the extent of postoperative tissue ongrowth over the stapes prosthesis: (2) objectively evaluate intra- and postoperative sound transmission properties of revision stapes surgery and compare the findings to those from primary surgery; (3) quantify the influence of ongrown tissue on sound transmission after stapes surgery.
A group of 10 patients undergoing revision stapes surgery was investigated with audiological evaluations and intraoperative laser Doppler interferometry, and with scanning electron microscopy of the explanted incus with its adherent prosthesis in 6 patients. Results were compared to a group of patients undergoing primary otosclerosis surgery and temporal bone experiments.
Results indicated that tissue grows over the prosthesis, as identified in all specimens. Sound transmission properties were evaluated intraoperatively (i.e., incus mobility and prosthesis-fixation quality), and found to correlate well with the functional hearing results. Ongrowing mucosa in the incus-prosthesis interface had only a minimal effect on sound transmission properties and cannot compensate adequately for insufficient prosthesis fixation. Therefore, it is essential that the stapes prosthesis is properly fixed during primary otosclerosis surgery. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sim, Jae Hoon] Univ Spital Zurich, ORL Klin, CH-8091 Zurich, Switzerland.
RP Sim, JH (reprint author), Univ Spital Zurich, ORL Klin, Frauenklin Str 24, CH-8091 Zurich, Switzerland.
EM JaeHoon.Sim@usz.ch
RI Huber, Alexander/A-2693-2009
OI Huber, Alexander/0000-0002-8888-8483
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NR 8
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 38
EP 42
DI 10.1016/j.heares.2009.08.012
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700007
PM 19766180
ER
PT J
AU Voss, SE
Adegoke, MF
Horton, NJ
Sheth, KN
Rosand, J
Shera, CA
AF Voss, Susan E.
Adegoke, Modupe F.
Horton, Nicholas J.
Sheth, Kevin N.
Rosand, Jonathan
Shera, Christopher A.
TI Posture systematically alters ear-canal reflectance and DPOAE properties
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
ID PRODUCT OTOACOUSTIC EMISSIONS; INTRACRANIAL-PRESSURE CHANGES; TYMPANIC
MEMBRANE DISPLACEMENT; DISTORTION-PRODUCT; MIDDLE-EAR; IMPEDANCE;
BEHAVIOR; ADULTS; REPEATABILITY; TRANSMISSION
AB Several studies have demonstrated that the auditory system is sensitive to changes in posture, presumably through changes in intracranial pressure (ICP) that in turn alter the intracochlear pressure, which affects the stiffness of the middle-ear system. This observation has led to efforts to develop an ear-canal based noninvasive diagnostic measure for monitoring ICP, which is currently monitored invasively via access through the skull or spine. Here, we demonstrate the effects of postural changes, and presumably ICP changes, on distortion product otoacoustic emissions (DPOAE) magnitude, DPOAE angle, and power reflectance. Measurements were made on 12 normal-hearing subjects in two postural positions: upright at 90 degrees and tilted at -45 degrees to the horizontal. Measurements on each subject were repeated five times across five separate measurement sessions. All three measures showed significant changes (p < 0.001) between upright and tilted for frequencies between 500 and 2000 Hz, and DPOAE angle changes were significant at all measured frequencies (500-4000 Hz). Intra-subject variability, assessed via standard deviations for each subject's multiple measurements, were generally smaller in the upright position relative to the tilted position. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Voss, Susan E.; Adegoke, Modupe F.] Smith Coll, Picker Engn Program, Northampton, MA 01063 USA.
[Horton, Nicholas J.] Smith Coll, Dept Math & Stat, Northampton, MA 01063 USA.
[Sheth, Kevin N.] Univ Maryland, Sch Med, Dept Neurol, Div Stroke & Neurocrit Care, Baltimore, MD 21201 USA.
[Rosand, Jonathan] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
[Shera, Christopher A.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, Boston, MA USA.
RP Voss, SE (reprint author), Smith Coll, Picker Engn Program, 51 Coll Lane, Northampton, MA 01063 USA.
EM svoss@smith.edu; madegoke@smith.edu; nhorton@smith.edu;
kshethmd@gmail.com; rosand@chgr.mgh.harvard.edu;
shera@epl.meei.harvard.edu
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NR 43
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 43
EP 51
DI 10.1016/j.heares.2010.03.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700008
PM 20227475
ER
PT J
AU Keefe, DH
Fitzpatrick, D
Liu, YW
Sanford, CA
Gorga, MP
AF Keefe, Douglas H.
Fitzpatrick, Denis
Liu, Yi-Wen
Sanford, Chris A.
Gorga, Michael P.
TI Wideband acoustic-reflex test in a test battery to predict middle-ear
dysfunction
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Acoustic reflex; Middle-ear muscle; Medial olivocochlear efferent;
Newborn hearing screening
ID FREQUENCY OTOACOUSTIC EMISSIONS; FINITE-ELEMENT MODEL; STAPEDIAL REFLEX;
REFLECTANCE; ADULTS; THRESHOLDS; ADMITTANCE; INFANTS; HEARING;
TYMPANOMETRY
AB A wideband (WB) aural acoustical test battery of middle-ear status, including acoustic-reflex thresholds (ARTs) and acoustic-transfer functions (ATFs, i.e., absorbance and admittance) was hypothesized to be more accurate than 1-kHz tympanometry in classifying ears that pass or refer on a newborn hearing screening (NHS) protocol based on otoacoustic emissions. Assessment of middle-ear status may improve NHS programs by identifying conductive dysfunction and cases in which auditory neuropathy exists. Ipsi-lateral ARTs were assessed with a stimulus including four broadband-noise or tonal activator pulses alternating with five clicks presented before, between and after the pulses. The reflex shift was defined as the difference between final and initial click responses. ARTs were measured using maximum likelihood both at low frequencies (0.8-2.8 kHz) and high (2.8-8 kHz). The median low-frequency ART was elevated by 24 dB in NHS refers compared to passes. An optimal combination of ATF and ART tests performed better than either test alone in predicting NHS outcomes, and WB tests performed better than 1-kHz tympanometry. Medial olivocochlear efferent shifts in cochlear function may influence ARs, but their presence would also be consistent with normal conductive function. Baseline clinical and WB ARTs were also compared in ipsilateral and contralateral measurements in adults. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Keefe, Douglas H.; Fitzpatrick, Denis; Liu, Yi-Wen; Sanford, Chris A.; Gorga, Michael P.] Boys Town Natl Res Hosp, Omaha, NE 68131 USA.
RP Keefe, DH (reprint author), Boys Town Natl Res Hosp, 555 N 30th St, Omaha, NE 68131 USA.
EM keefe@boystown.org; fitzpatrickd@boystown.org; liuy@boystown.org;
sanfchri@isu.edu; gorga@boystown.org
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NR 38
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 52
EP 65
DI 10.1016/j.heares.2009.09.008
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700009
PM 19772907
ER
PT J
AU Cheng, JT
Aarnisalo, AA
Harrington, E
Hernandez-Montes, MD
Furlong, C
Merchant, SN
Rosowski, JJ
AF Cheng, Jeffrey Tao
Aarnisalo, Antti A.
Harrington, Ellery
Hernandez-Montes, Maria del Socorro
Furlong, Cosme
Merchant, Saumil N.
Rosowski, John J.
TI Motion of the surface of the human tympanic membrane measured with
stroboscopic holography
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Tympanic membrane; Wave motion; Stroboscopic holography; Middle ear
mechanics
ID TIME-AVERAGED HOLOGRAPHY; MIDDLE-EAR TRANSMISSION; FINITE-ELEMENT
METHOD; VIBRATION MEASUREMENT; SOUND-TRANSMISSION; CAT EARDRUM; MODEL;
GERBIL; KHZ
AB Sound-induced motion of the surface of the human tympanic membrane (TM) was studied by stroboscopic holographic interferometery, which measures the amplitude and phase of the displacement at each of about 40,000 points on the surface of the TM. Measurements were made with tonal stimuli of 0.5, 1, 4 and 8 kHz. The magnitude and phase of the sinusoidal displacement of the TM at each driven frequency were derived from the fundamental Fourier component of the raw displacement data computed from stroboscopic holograms of the TM recorded at eight stimulus phases. The correlation between the Fourier estimates and measured motion data was generally above 0.9 over the entire TM surface. We used three data presentations: (i) plots of the phasic displacements along a single chord across the surface of the TM, (ii) phasic surface maps of the displacement of the entire TM surface, and (iii) plots of the Fourier derived amplitude and phase-angle of the surface displacement along four diameter lines that define and bisect each of the four quadrants of the TM. These displays led to some common conclusions: at 0.5 and 1 kHz, the entire TM moved roughly in-phase with some small phase delay apparent between local areas of maximal displacement in the posterior half of the TM. At 4 and 8 kHz, the motion of the TM became more complicated with multiple local displacement maxima arranged in rings around the manubrium. The displacements at most of these maxima were roughly in-phase, while some moved out-of-phase. Superposed on this in- and out-of-phase behavior were significant cyclic variations in-phase with location of less than 0.2 cycles or occasionally rapid half-cycle step-like changes in-phase. The high frequency displacement amplitude and phase maps discovered in this study can not be explained by any single wave motion, but are consistent with a combination of low and higher order modal motions plus some small traveling-wave-like components. The observations of the dynamics of TM surface motion from this study will help us better understand the sound-receiving function of the TM and how it couples sound to the ossicular chain and inner ear. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Cheng, Jeffrey Tao; Aarnisalo, Antti A.; Furlong, Cosme; Merchant, Saumil N.; Rosowski, John J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Cheng, Jeffrey Tao; Aarnisalo, Antti A.; Furlong, Cosme; Merchant, Saumil N.; Rosowski, John J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Rosowski, John J.] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Bioscience & Technol Program, Cambridge, MA 02139 USA.
[Harrington, Ellery; Hernandez-Montes, Maria del Socorro; Furlong, Cosme] Worcester Polytech Inst, Ctr Holog Studies & Laser MicromechaTron, Worcester, MA 01609 USA.
[Hernandez-Montes, Maria del Socorro; Furlong, Cosme] Worcester Polytech Inst, Dept Mech Engn, Worcester, MA 01609 USA.
RP Cheng, JT (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM Tao_Cheng@meei.harvard.edu
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NR 31
TC 47
Z9 47
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 66
EP 77
DI 10.1016/j.heares.2009.12.024
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700010
PM 20034549
ER
PT J
AU Aarnisalo, AA
Cheng, JT
Ravicz, ME
Furlong, C
Merchant, SN
Rosowski, JJ
AF Aarnisalo, Antti A.
Cheng, Jeffrey T.
Ravicz, Michael E.
Furlong, Cosme
Merchant, Saumil N.
Rosowski, John J.
TI Motion of the tympanic membrane after cartilage tympanoplasty determined
by stroboscopic holography
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Tympanic membrane; Tympanoplasty; Stroboscopic holography
ID FINITE-ELEMENT-ANALYSIS; HUMAN EAR; IMPEDANCE; RECONSTRUCTION;
MYRINGOPLASTY; TRANSMISSION; OPTIMIZATION; REFLECTANCE; VIBRATION;
EARDRUM
AB Stroboscopic holography was used to quantify dynamic deformations of the tympanic membrane (TM) of the entire surface of the TM before and after cartilage tympanoplasty of the posterior or posterior-superior part of the TM. Cartilage is widely used in tympanoplasties to provide mechanical stability for the TM.
Three human cadaveric temporal bones were used. A 6 mm x 3 mm oval cartilage graft was placed through the widely opened facial recess onto the medial surface of the posterior or posterior-superior part of the TM. The graft was either in contact with the bony tympanic rim and manubrium or not. Graft thickness was either 0.5 or 1.0 mm. Stroboscopic holography produced displacement amplitude and phase maps of the TM surface in response to stimulus sound. Sound stimuli were 0.5, 1, 4 and 7 (or 8) kHz tones. Middle-ear impedance was measured from the motion of the entire TM.
Cartilage placement generally produced reductions in the motion of the TM apposed to the cartilage, especially at 4 kHz and 7 or 8 kHz. Some parts of the TM showed altered motion compared to the control in all three cases. In general, middle-ear impedance was either unchanged or increased somewhat after cartilage reconstruction both at low (0.5 and 1 kHz) and high (4 and 7 kHz) frequencies. At 4 kHz, with the 1.0 mm thick graft that was in contact with the bony tympanic rim, the impedance slightly decreased.
While our earlier work with time-averaged holography allowed us to observe differences in the pattern of TM motion caused by application of cartilage to the TM, stroboscopic holography is more sensitive to TM motions and allowed us to quantify the magnitude and phase of motion of each point on the TM surface. Nonetheless, our results are similar to those of our earlier work: The placement of cartilage on the medial surface of TM reduces the motion of the TM that apposes the cartilage. These obvious local changes occur even though the cartilage had little effect on the sound-induced motion of the stapes. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Aarnisalo, Antti A.; Cheng, Jeffrey T.; Ravicz, Michael E.; Furlong, Cosme; Merchant, Saumil N.; Rosowski, John J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Aarnisalo, Antti A.; Cheng, Jeffrey T.; Furlong, Cosme; Merchant, Saumil N.; Rosowski, John J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Furlong, Cosme] Worcester Polytech Inst, Dept Mech Engn, Worcester, MA 01609 USA.
[Furlong, Cosme; Merchant, Saumil N.; Rosowski, John J.] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
RP Aarnisalo, AA (reprint author), Univ Helsinki, Cent Hosp, Dept Otorhinolaryngol, POB 220, Hus Helsinki 00029, Finland.
EM antti.aarnisalo@helsinki.fi
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NR 28
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 78
EP 84
DI 10.1016/j.heares.2009.11.005
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700011
PM 19909803
ER
PT J
AU Popelka, GR
Telukuntla, G
Puria, S
AF Popelka, Gerald R.
Telukuntla, Goutham
Puria, Sunil
TI Middle-ear function at high frequencies quantified with advanced
bone-conduction measures
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE High frequency; Bone conduction; Air conduction; Magnetostrictive
transducer; Conductive mechanism; Sensorineural mechanism
ID TYMPANIC MEMBRANE; HEARING; SPEECH
AB Auditory thresholds with standardized clinical procedures are obtained over a much narrower frequency range by bone conduction than by air conduction. As a result, diagnostic information for both sensorineural and conductive-mechanism function is incomplete for high frequencies. A new magnetostrictive bone-conduction transducer that has the potential for improved output in the high-frequency rang was evaluated in the laboratory and in a variety of subjects with normal hearing (N = 11) or sensorineural hearing loss (N = 9). Laboratory results indicated that harmonic distortion and acoustic radiation were both sufficiently low to allow accurate threshold measurements. Auditory thresholds obtained with this magnetostrictive bone-conduction transducer can be measured accurately under conventional clinical conditions for frequencies up to 16 kHz and levels up to 85 dB HL These measures can be used to accurately characterize sensorineural hearing sensitivity for high frequencies and, when combined with standard air-conduction measures for high frequencies, to accurately characterize conductive-mechanism function for frequencies higher than possible with current diagnostic bone-conduction technology. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Popelka, Gerald R.; Telukuntla, Goutham; Puria, Sunil] Stanford Univ, Dept Otolaryngol, Stanford, CA 94305 USA.
[Puria, Sunil] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA.
RP Popelka, GR (reprint author), Stanford Univ, Dept Otolaryngol, 801 Welch Rd, Stanford, CA 94305 USA.
EM gpopelka@stanford.edu; gtelukuntla@stanfordmed.edu; puria@stanford.edu
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NR 18
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 85
EP 92
DI 10.1016/j.heares.2009.11.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700012
PM 19900526
ER
PT J
AU Qin, ZB
Wood, M
Rosowski, JJ
AF Qin, Zhaobing
Wood, Melissa
Rosowski, John J.
TI Measurement of conductive hearing loss in mice
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle-ear pathology; Distortion-product otoacoustic emissions; Auditory
brainstem responses; Umbo velocity; Mouse
ID PRODUCT OTOACOUSTIC EMISSIONS; MIDDLE-EAR FUNCTION; TYMPANIC-MEMBRANE;
THRESHOLD ESTIMATION; COCHLEAR DISORDERS; UMBO VELOCITY; GUINEA-PIGS;
TRANSMISSION; DIFFERENTIATION; PERFORATION
AB In order to discriminate conductive hearing loss from sensorineural impairment, quantitative measurements were used to evaluate the effect of artificial conductive pathology on distortion-product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABRs) and laser-Doppler vibrometry (LDV) in mice. The conductive manipulations were created by perforating the pars flaccida of the tympanic membrane, filling or partially filling the middle-ear cavity with saline, fixing the ossicular chain, and interrupting the incudo-stapedial joint. In the saline-filled and ossicular-fixation groups, averaged DPOAE thresholds increased relative to the control state by 20-36 and 25-39 dB, respectively with the largest threshold shifts occurring at frequencies less than 20 kHz, while averaged ABR thresholds increased 12-19 and 12-25 dB, respectively without the predominant low-frequency effect. Both DPOAE and ABR thresholds were elevated by less than 10 dB in the half-filled saline condition; no significant change was observed after pars flaccida perforation. Conductive pathology generally produced a change in DPOAE threshold in dB that was 1.5-2.5 times larger than the ABR threshold change at frequencies less than 30 kHz; the changes in the two thresholds were nearly equal at the highest frequencies. While mild conductive pathology (ABR threshold shifts of <10 dB) produced parallel shifts in DPOAE growth with level functions, manipulations that produced larger conductive hearing losses (ABR threshold shifts >10 dB) were associated with significant deceases in DPOAE growth rate. Our LDV measurements are consistent with others and suggest that measurements of umbo velocity are not an accurate indicator of conductive hearing loss produced by ossicular lesions in mice. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Qin, Zhaobing; Wood, Melissa; Rosowski, John J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Qin, Zhaobing] Zhengzhou Univ, Teaching Hosp 1, Zhengzhou 450052, Henan, Peoples R China.
RP Rosowski, JJ (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM john_Rosowski@meei.harvard.edu
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NR 46
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 93
EP 103
DI 10.1016/j.heares.2009.10.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700013
PM 19835942
ER
PT J
AU Perkins, R
Fay, JP
Rucker, P
Rosen, M
Olson, L
Puria, S
AF Perkins, Rodney
Fay, Jonathan P.
Rucker, Paul
Rosen, Micha
Olson, Lisa
Puria, Sunil
TI The EarLens system: New sound transduction methods
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Hearing aid; Tympanic membrane; Transducers; Electromagnetic hearing;
Photonic hearing; Speech in noise; Sound processing
ID HIGH-FREQUENCIES; TYMPANIC MEMBRANE; PRESSURE LEVELS; SPECTRAL CUES;
DEAD REGIONS; EXTERNAL-EAR; HEARING-AIDS; MIDDLE-EAR; SPEECH;
LOCALIZATION
AB The hypothesis is tested that an open-canal hearing device, with a microphone in the ear canal, can be designed to provide amplification over a wide bandwidth and without acoustic feedback. In the design under consideration, a transducer consisting of a thin silicone platform with an embedded magnet is placed directly on the tympanic membrane. Sound picked up by a microphone in the ear canal, including sound-localization cues thought to be useful for speech perception in noisy environments, is processed and amplified, and then used to drive a coil near the tympanic-membrane transducer. The perception of sound results from the vibration of the transducer in response the electromagnetic field produced by the coil. Sixteen subjects (ranging from normal-hearing to moderately hearing-impaired) wore this transducer for up to a 10-month period, and were monitored for any adverse reactions. Three key functional characteristics were measured: (1) the maximum equivalent pressure output (MEPO) of the transducer; (2) the feedback gain margin (GM), which describes the maximum allowable gain before feedback occurs: and (3) the tympanic-membrane damping effect (D(TM)), which describes the change in hearing level due to placement of the transducer on the eardrum. Results indicate that the tympanic-membrane transducer remains in place and is well tolerated. The system can produce sufficient output to reach threshold for those with as much as 60 dBHL of hearing impairment for up to 8 kHz in 86% of the study population, and up to 11.2 kHz in 50% of the population. The feedback gain margin is on average 30 dB except at the ear-canal resonance frequencies of 3 and 9 kHz, where the average was reduced to 12 dB and 23 dB, respectively. The average value of D(TM) is close to 0 dB everywhere except in the 2-4 kHz range, where it peaks at 8 dB. A new alternative system that uses photonic energy to transmit both the signal and power to a photodiode and micro-actuator on an EarLens platform is also described. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Perkins, Rodney; Fay, Jonathan P.; Rucker, Paul; Rosen, Micha; Olson, Lisa; Puria, Sunil] EarLens Corp, Redwood City, CA 94063 USA.
[Puria, Sunil] Stanford Univ, Dept Mech Engn, Mech & Computat Div, Stanford, CA 94305 USA.
RP Puria, S (reprint author), EarLens Corp, 200 Chesapeake Dr, Redwood City, CA 94063 USA.
EM spuria@earlenscorp.com
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NR 44
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 104
EP 113
DI 10.1016/j.heares.2010.01.012
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700014
PM 20116419
ER
PT J
AU Nakajima, HH
Merchant, SN
Rosowski, JJ
AF Nakajima, Hideko Heidi
Merchant, Saumil N.
Rosowski, John J.
TI Performance considerations of prosthetic actuators for round-window
stimulation
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Round window; Middle ear; Cochlea; Scala vestibuli; Scala tympani;
Prosthesis
ID SOUND PRESSURE MEASUREMENTS; MIDDLE-EAR IMPLANT; VIBRANT SOUNDBRIDGE;
COCHLEA; RECONSTRUCTION; OVAL
AB Round-window (RW) stimulation has improved speech perception in patients with mixed hearing loss. In cadaveric temporal bones, we recently showed that RW stimulation with an active prosthesis produced differential pressure across the cochlear partition (a measure related to cochlear transduction) similar to normal forward sound stimulation above 1 kHz, when contact area between the prosthesis and RW is secured. However, there is large variability in the hearing improvement in patients implanted with existing modified prosthesis. This is likely because the middle-ear prosthesis used for RW stimulation was designed for a very different application.
In this paper, we utilize recently developed experimental techniques that allow for the calculation of performance specifications for a RW actuator. In cadaveric human temporal bones (N = 3), we simultaneously measure scala vestibuli and scala tympani intracochlear pressures, as well as stapes velocity and ear-canal pressure, during normal forward sound stimulation as well as reverse RW stimulation. We then calculate specifications such as the impedance the actuator will need to oppose at the RW, the force with which it must push against the RW, and the velocity and distance by which it must move the RW to obtain cochlear stimulation equivalent to that of specific levels of ear-canal pressure under normal sound stimulation. This information is essential for adapting existing prostheses and for designing new actuators specifically for RW stimulation. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Nakajima, Hideko Heidi; Merchant, Saumil N.; Rosowski, John J.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Nakajima, Hideko Heidi; Merchant, Saumil N.; Rosowski, John J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Merchant, Saumil N.; Rosowski, John J.] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Bioscience & Technol Program, Cambridge, MA 02139 USA.
RP Nakajima, HH (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM heidi_nakajima@meei.harvard.edu; saumil_-merchant@meei.harvard.edu;
john_rosowski@meei.harvard.edu
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NR 19
TC 10
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 114
EP 119
DI 10.1016/j.heares.2009.11.009
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700015
PM 19941946
ER
PT J
AU Arnold, A
Kompis, M
Candreia, C
Pfiffner, F
Hausler, R
Stieger, C
AF Arnold, Andreas
Kompis, Martin
Candreia, Claudia
Pfiffner, Flurin
Haeusler, Rudolf
Stieger, Christof
TI The floating mass transducer at the round window: Direct transmission or
bone conduction?
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Floating mass transducer (FMT); Vibrant Soundbridge (VSB); Round window;
Promontory; Laser Doppler vibrometry; Bone anchored hearing aid (BAHA);
Bone conduction
ID HUMAN TEMPORAL BONES; MIXED HEARING-LOSS; MIDDLE-EAR; VIBRANT
SOUNDBRIDGE; SOUND; AID; THRESHOLDS; FEASIBILITY; STIMULATION;
VIBRATIONS
AB The round window placement of a floating mass transducer (FMT) is a new approach for coupling an implantable hearing system to the cochlea. We evaluated the vibration transfer to the cochlear fluids of an FMT placed at the round window (rwFMT) with special attention to the role of bone conduction. A posterior tympanotomy was performed on eleven ears of seven human whole head specimens. Several rwFMT setups were examined using laser Doppler vibrometry measurements at the stapes and the promontory. In three ears, the vibrations of a bone anchored hearing aid (BAHA) and an FMT fixed to the promontory (pFMT) were compared to explore the role of bone conduction. Vibration transmission to the measuring point at the stapes was best when the rwFMT was perpendicularly placed in the round window and underlayed with connective tissue. Fixation of the rwFMT to the round window exhibited significantly lower vibration transmission. Although measurable, bone conduction from the pFMT was much lower than that of the BAHA. Our results suggest that the rwFMT does not act as a small bone anchored hearing aid, but instead, acts as a direct vibratory stimulator of the round window membrane. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Arnold, Andreas; Kompis, Martin; Candreia, Claudia; Pfiffner, Flurin; Haeusler, Rudolf; Stieger, Christof] Univ Bern, Inselspital, Univ Dept ENT Head & Neck Surg, CH-3012 Bern, Switzerland.
[Stieger, Christof] Univ Bern, ARTORG Ctr Biomed Engn, CH-3012 Bern, Switzerland.
RP Arnold, A (reprint author), Univ Bern, Inselspital, Univ Dept ENT Head & Neck Surg, CH-3012 Bern, Switzerland.
EM andreas.arnold@insel.ch; martin.kompis@insel.ch;
claudia.candreia@insel.ch; flurin.pfiffner@dkf.unibe.ch;
rudolf.haeusler@insel.ch; christof.stieger@artorg.unibe.ch
RI Arnold, Andreas/H-2749-2012
CR AMBETT R, 2009, 5 INT S MIDDL EAR ME
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NR 36
TC 16
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 120
EP 127
DI 10.1016/j.heares.2009.12.019
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700016
PM 20005939
ER
PT J
AU Koka, K
Holland, NJ
Lupo, JE
Jenkins, HA
Tollin, DJ
AF Koka, Kanthaiah
Holland, N. Julian
Lupo, J. Eric
Jenkins, Herman A.
Tollin, Daniel J.
TI Electrocochleographic and mechanical assessment of round window
stimulation with an active middle ear prosthesis
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Cochlear microphonic; RW stimulation; Active middle ear prosthesis
ID IMPLANTABLE HEARING DEVICE; CHINCHILLA; RECONSTRUCTION; ADMITTANCE;
COCHLEA
AB Mechanical stimulation of the round window (RW) with an active middle ear prosthesis (AMEP) has shown functional benefit in clinical reports in patients with mixed hearing loss (MHL). Further objective physiological data on the efficacy of RW stimulation is needed, however, to demonstrate that RW stimulation with an AMEP can generate input to the inner ear comparable to acoustic input.
Cochlear microphonic (CM) and mechanical (stapes velocity) responses to sinusoidal stimuli were measured by electrode and laser Doppler vibrometry in eight chinchillas in response to normal acoustic stimulation via sealed calibrated insert earphones and to AMEP stimulation (Otologics MET, Boulder, CO, USA) of the RW with and without lateral ossicular chain disarticulation.
CM thresholds for acoustic stimulation were frequency dependent and ranged from 16 to 50 dB SPL. CM thresholds measured with RW stimulation ranged from -14 to 35 dB mV with an intact middle ear chain and from -7 to 36 dB mV after lateral ossicular chain disarticulation. Acoustically, stapes velocity maxima was observed at similar to 700 Hz and minima at similar to 2.65 kHz. With application of the AMEP to the RW, peak stapes velocity was observed at 2-3 kHz. The equivalent ear canal sound pressure level (L(Emax) dB SPL) evoked by RW stimulation with the AMEP was 60-105 dB SPL for the intact middle ear and 70-100 dB SPL after ossicular chain disarticulation.
Stimulating the inner ear through the RW with an AMEP produces evoked responses (CM) comparable to normal acoustic input. When adjusted for threshold (due to unit differences, dB SPL or dB mV), the sensitivity of the CM (slope) for acoustic was comparable to sensitivities obtained by AMEP stimulation of the RW. Mechanical stimulation of the RW with an AMEP produces cochlear responses (CMs) and stapes velocities that are functionally equivalent to acoustic stimulation. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Koka, Kanthaiah; Lupo, J. Eric; Tollin, Daniel J.] Univ Colorado Denver, Dept Physiol & Biophys, Aurora, CO 80045 USA.
[Holland, N. Julian; Jenkins, Herman A.; Tollin, Daniel J.] Univ Colorado Denver, Dept Otolaryngol, Aurora, CO 80045 USA.
RP Koka, K (reprint author), Univ Colorado Denver, Dept Physiol & Biophys, Mail Stop 8307,POB 6511,12800 E 19th Ave, Aurora, CO 80045 USA.
EM kanthaiah.koka@ucdenver.edu
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NR 22
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 128
EP 137
DI 10.1016/j.heares.2009.08.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700017
PM 19720125
ER
PT J
AU Gan, RZ
Dai, CK
Wang, XL
Nakmali, D
Wood, MW
AF Gan, Rong Z.
Dai, Chenkai
Wang, Xuelin
Nakmali, Don
Wood, Mark W.
TI A totally implantable hearing system - Design and function
characterization in 3D computational model and temporal bones
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle ear; Implantable device; Biomechanics; Finite element model
ID SOUND-TRANSMISSION; CLINICAL-TRIAL; EAR; DEVICE; TRANSDUCER; MET
AB Implantable middle ear hearing devices are emerging as an effective technology for patients with mild to moderately severe sensorineural hearing loss. Several devices with electromagnetic or piezoelectric transducers have been investigated or developed in the US and Europe since 1990. This paper reports a totally implantable hearing system (TIHS) currently under investigation in Oklahoma. The TIHS consists of implant transducer (magnet), implantable coil and microphone, DSP-audio signal processor, rechargeable battery, and remote control unit. The design of TINS is based on a 3D finite element model of the human ear and the analysis of electromagnetic coupling of the transducer. Function of the TIHS is characterized over the auditory frequency range in three aspects: (1) mass loading effect on residual hearing with a passive implant, (2) efficiency of electromagnetic coupling between the implanted coil and magnet, and (3) functional gain of whole unit in response to acoustic input across the human skin. This paper focuses on mass loading effect and the efficiency of electromagnetic coupling of TIHS determined from the FE model of the human ear and the cadaver ears or temporal bones. Some preliminary data of whole unit function are also presented in the paper. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Gan, Rong Z.] Univ Oklahoma, Sch Aerosp & Mech Engn, Norman, OK 73019 USA.
[Nakmali, Don; Wood, Mark W.] Hough Ear Inst, Oklahoma City, OK 73112 USA.
RP Gan, RZ (reprint author), Univ Oklahoma, Sch Aerosp & Mech Engn, 865 Asp Ave,Room 200, Norman, OK 73019 USA.
EM rgan@ou.edu
CR *ASTM INT, 2005, F250405 ASTM INT
Chen DA, 2004, OTOLARYNG HEAD NECK, V131, P904, DOI 10.1016/j.otohns.2004.05.027
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NR 22
TC 8
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 138
EP 144
DI 10.1016/j.heares.2009.09.003
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700018
PM 19772909
ER
PT J
AU Bornitz, M
Hardtke, HJ
Zahnert, T
AF Bornitz, Matthias
Hardtke, Hans-Juergen
Zahnert, Thomas
TI Evaluation of implantable actuators by means of a middle ear simulation
model
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle ear; Implantable hearing aids; Finite element model; Actuator
ID SENSORINEURAL HEARING-LOSS; HUMAN TEMPORAL BONES; DEVICE; TRANSDUCER;
CRYSTAL; SYSTEMS
AB The extension of indication of implantable hearing aids to cases of conductive hearing loss pushed the development of these devices. There is now a great variety of devices available with different actuator concepts and different attachment points to the middle ear or inner ear fluid. But there is little comparative data available about the devices to provide an insight into advantages and disadvantages of different types of actuators and attachment points at the ossicular chain.
This paper investigates two principle (idealized) types of actuators in respect of attachments points at the ossicular chain and direction of excitation. Other parts of implantable hearing aids like microphone, amplifier and signal processing electronics were not incorporated into this study.
Investigations were performed by means of a mathematical simulation model of the middle ear (finite element model). Actuator performance and theoretical gain were calculated by harmonic analysis in the frequency range of 100-6000 Hz and were compared for the different situations.
The stapes head proofed to be an ideal attachment point for actuators of both types as this position is very insensitive to changes in the direction of excitation. The implantable actuators showed higher ratio of equivalent sound pressure to radiated sound pressure compared to an open hearing aid transducer and should therefore allow for more functional gain. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Bornitz, Matthias; Zahnert, Thomas] Tech Univ Dresden, Dept Med, Clin Otolaryngol, D-01307 Dresden, Germany.
[Hardtke, Hans-Juergen] Tech Univ Dresden, Dept Mech Engn, Inst Solid Mech, D-01307 Dresden, Germany.
RP Bornitz, M (reprint author), Tech Univ Dresden, Dept Med, Clin Otolaryngol, Fetscherstr 74, D-01307 Dresden, Germany.
EM matthias.bornitz@tu-dresden.de
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NR 23
TC 15
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 145
EP 151
DI 10.1016/j.heares.2010.02.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700019
PM 20156543
ER
PT J
AU Parent, P
Allen, JB
AF Parent, Pierre
Allen, Jont B.
TI Time-domain "wave" model of the human tympanic membrane
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle ear; Model; Time domain; Impedance; Reflectance; Human
ID HUMAN MIDDLE-EAR; CAT EARDRUM; ENERGY REFLECTANCE; INPUT IMPEDANCE;
SOUND-LEVEL; INNER-EAR; IN-SITU; PRESSURE; CALIBRATION; INTENSITY
AB Middle ear models have been successfully developed for many years. Most of those are implemented in the frequency domain, where physical equations are more easily derived. This is problematic, however, when it comes to model non-linear phenomena, especially in the cochlea, and because a frequency-domain implementation may be less intuitive. This research explores a different approach, based on a time-domain implementation, fitted to impedance data. It is adapted from a previous work for the cat and focuses here on the human ear: volume velocity samples are distributed uniformly in space and updated periodically to simulate the propagation of the sound wave in the ear. The modeling approach is simple, yet it can quantitatively reproduce the major characteristics of the human middle ear transmission, and can qualitatively capture forward and reverse power transmission - a key feature of this time-domain implementation. These results suggest that complex, multi-modal propagation observed on the TM may not be critical to proper sound transmission along the ear. Besides, model predictions reveal that impedance and velocimetry measurements may be inconsistent with each other, hypothetically because velocimetry protocols could alter the middle ear. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Parent, Pierre] Mimosa Acoust Inc, Champaign, IL 61820 USA.
[Allen, Jont B.] Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Urbana, IL 61801 USA.
RP Parent, P (reprint author), Mimosa Acoust Inc, 335 Fremont St, Champaign, IL 61820 USA.
EM pierre@mimosaacoustics.com; jontalle@uiuc.edu
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NR 44
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 152
EP 167
DI 10.1016/j.heares.2009.12.015
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700020
PM 20004714
ER
PT J
AU Hesabgar, SM
Marshall, H
Agrawal, SK
Samani, A
Ladak, HM
AF Hesabgar, S. Mohammad
Marshall, Harry
Agrawal, Sumit K.
Samani, Abbas
Ladak, Hanif M.
TI Measuring the quasi-static Young's modulus of the eardrum using an
indentation technique
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Eardrum; Young's modulus; Indentation; Finite element method;
Optimization
ID FINITE-ELEMENT MODEL; HUMAN MIDDLE-EAR; HUMAN TYMPANIC MEMBRANE; CAT
EARDRUM; ELASTIC-MODULUS; BEHAVIOR; TISSUES; SAMPLES
AB Accurate estimation of the quasi-static Young's modulus of the eardrum is important for finite-element modeling. In this study, we adapted a tissue indentation technique and inverse finite-element analysis to estimate the Young's modulus of the eardrum. A custom-built indentation apparatus was used to perform indentation testing on seven rat eardrums in situ after immobilizing the malleus. Testing was done in most cases on the posterior pars tensa. The unloaded shape of each eardrum was measured and used to construct finite-element models with subject-specific geometries to simulate the indentation experiment. The Young's modulus of each specimen was then estimated by numerically optimizing the Young's modulus of each model so that simulation results matched corresponding experimental data. Using an estimated value of 12 mu m for the thickness of each model eardrum, the estimated average Young's modulus for the pars tensa was found to be 21.7 +/- 1.2 MPa. The estimated average Young's modulus is within the range reported in some of the literature. The estimation technique is sensitive to the thickness of the pars tensa used in the model but is not sensitive to relatively large variations in the stiffness of the pars flaccida and manubrium or to the pars tensa/pars flaccida separation conditions. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Marshall, Harry; Samani, Abbas; Ladak, Hanif M.] Univ Western Ontario, Dept Med Biophys, London, ON N6A 5C1, Canada.
[Agrawal, Sumit K.; Ladak, Hanif M.] Univ Western Ontario, Dept Otolaryngol, London, ON N6A 5C1, Canada.
[Ladak, Hanif M.] Univ Western Ontario, Natl Ctr Audiol, London, ON N6A 1H1, Canada.
[Hesabgar, S. Mohammad; Samani, Abbas; Ladak, Hanif M.] Univ Western Ontario, Dept Elect & Comp Engn, London, ON N6A 5B9, Canada.
RP Ladak, HM (reprint author), Univ Western Ontario, Dept Med Biophys, Med Sci Bldg, London, ON N6A 5C1, Canada.
EM shesabga@uwo.ca; hmarsha4@uwo.ca; sagrawa5@uwo.ca; asamani@uwo.ca;
hladak@uwo.ca
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NR 36
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 168
EP 176
DI 10.1016/j.heares.2010.02.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700021
PM 20146934
ER
PT J
AU Aernouts, J
Soons, JAM
Dirckx, JJJ
AF Aernouts, Jef
Soons, Joris A. M.
Dirckx, Joris J. J.
TI Quantification of tympanic membrane elasticity parameters from in situ
point indentation measurements: Validation and preliminary study
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Tympanic membrane elasticity; Point indentation; Inverse modeling
ID HUMAN MIDDLE-EAR; BEHAVIOR
AB Correct quantitative parameters to describe tympanic membrane elasticity are an important input for realistic modeling of middle ear mechanics. In the past, several attempts have been made to determine tympanic membrane elasticity from tensile experiments on cut-out strips. The strains and stresses in such experiments may be far out of the physiologically relevant range and the elasticity parameters are only partially determined.
We developed a setup to determine tympanic membrane elasticity in situ, using a combination of point micro-indentation and Moire profilometry. The measuring method was tested on latex phantom models of the tympanic membrane, and our results show that the correct parameters can be determined. These parameters were calculated by finite element simulation of the indentation experiment and parameter optimization routines.
When the apparatus was used for rabbit tympanic membranes, Moire profilometry showed that there is no measurable displacement of the manubrium during the small indentations. This result greatly simplifies boundary conditions, as we may regard both the annulus and the manubrium as fixed without having to rely on fixation interventions. The technique allows us to determine linear elastic material parameters of a tympanic membrane in situ. In this way our method takes into account the complex geometry of the membrane, and parameters are obtained in a physiologically relevant range of strain. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Aernouts, Jef; Soons, Joris A. M.; Dirckx, Joris J. J.] Univ Antwerp, Lab Biomed Phys, B-2020 Antwerp, Belgium.
RP Aernouts, J (reprint author), Univ Antwerp, Lab Biomed Phys, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
EM jef.aernouts@ua.ac.be
RI Soons, Joris/G-1552-2010
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NR 26
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 177
EP 182
DI 10.1016/j.heares.2009.09.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700022
PM 19778595
ER
PT J
AU Puria, S
Steele, C
AF Puria, Sunil
Steele, Charles
TI Tympanic-membrane and malleus-incus-complex co-adaptations for
high-frequency hearing in mammals
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Middle ear; Malleus-incus complex; Ossicles; Tympanic membrane; Moment
of inertia; Rotational motion; High-frequency hearing; Co-adaptation;
Micro-CT
ID MIDDLE-EAR; GUINEA-PIG; MODEL; CAT; JOINT; EVOLUTION
AB The development of the unique capacity for high-frequency hearing in many mammals was due in part to changes in the middle ear, such as the evolution of three distinct middle-ear bones and distinct radial and circumferential collagen fiber layers in the eardrum. Ossicular moment(s) of inertia (MOI) and principal rotational axes, as well as eardrum surface areas, were calculated from micro-CT-based 3-D reconstructions of human, cat, chinchilla, and guinea pig temporal bones. For guinea pig and chinchilla, the fused malleus-incus complex rotates about an anterior-posterior axis, due to the relatively lightweight ossicles and bilateral symmetry of the eardrum. For human and cat, however, the MOI calculated for the unfused malleus are 5-6 times smaller for rotations about an inferior-superior axis than for rotations about the other two orthogonal axes. It is argued that these preferred motions, along with the presence of a mobile malleus-incus joint and asymmetric eardrum, enable efficient high-frequency sound transmission in spite of the relatively large ossicular masses of these species. This work argues that the upper-frequency hearing limit of a given mammalian species can in part be understood in terms of morphological co-adaptations of the eardrum and ossicular chain. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Puria, Sunil; Steele, Charles] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA.
[Puria, Sunil] Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
[Puria, Sunil] Palo Alto Vet Adm, Palo Alto, CA 94304 USA.
RP Puria, S (reprint author), 496 Lomita Mall,Durand Bldg, Stanford, CA 94305 USA.
EM puria@stanford.edu
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NR 47
TC 26
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 183
EP 190
DI 10.1016/j.heares.2009.10.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700023
PM 19878714
ER
PT J
AU Offergeld, C
Kromeier, J
Merchant, SN
Lasurashvili, N
Neudert, M
Bornitz, M
Laszig, R
Zahnert, T
AF Offergeld, Christian
Kromeier, Jan
Merchant, Saumil N.
Lasurashvili, Nicoloz
Neudert, Marcus
Bornitz, Matthias
Laszig, Roland
Zahnert, Thomas
TI Experimental investigation of rotational tomography in reconstructed
middle ears with clinical implications
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Rotational tomography; Middle ear; Transfer function; Prostheses;
Imaging; Inclination angle
ID OSSICULAR CHAIN RECONSTRUCTION; TO-STAPES-HEAD; VIRTUAL ENDOSCOPY;
TEMPORAL BONE; SPIRAL CT; PROSTHESES; TITANIUM; OSSICULOPLASTY;
IMPLANTATION; MECHANICS
AB A large air-bone-gap after ossiculoplasty may be due to a malpositioned or displaced prosthesis. Rotational tomography (RT) has the potential to provide high-resolution images of implants without artifacts and with less radiation dosage than CT scan.
Twenty-seven temporal bone specimens underwent measurements of middle ear transfer function using Laser-Doppler-Vibrometry (LDV) before and after placement of ossicular replacement prostheses (PORPs, TORPs) made of titanium. RT was performed on all specimens.
RT allowed 3-dimensional viewing of the temporal bone, accurate localization of implants within the reconstructed middle ear and determination of angles between the inserted prostheses and the tympanic membrane (TM) and/or the malleus handle (MH). Presence or absence of contact between the implant and the TM, malleus or stapes could be clearly visualized. Displaced prostheses were readily identified. The functional LDV-measurements for TORPs showed a trend favoring coupling to the malleus handle, while for PORPs, coupling to the TM was favored. For PORPs, sound transmission was worse with increasing angles between the PORP and stapes superstructure (p < 0.05).
Following our experimental results RT is an innovative, relevant and useful imaging technique to obtain immediate postoperative feedback after ossicular reconstruction and to precisely determine the position of middle ear implants. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Offergeld, Christian; Laszig, Roland] Univ Freiburg, HNS, Dept ORL, D-79106 Freiburg, Germany.
[Kromeier, Jan] St Josefs Hosp, Dept Radiol, D-79104 Freiburg, Germany.
[Merchant, Saumil N.] Harvard Univ, Sch Med, Dept Otol & Laryngol, MEEI, Boston, MA 02114 USA.
[Lasurashvili, Nicoloz; Neudert, Marcus; Bornitz, Matthias; Zahnert, Thomas] Univ Dresden, Dept ORL, HNS, D-01307 Dresden, Germany.
RP Offergeld, C (reprint author), Univ Freiburg, HNS, Dept ORL, Killianstr 5, D-79106 Freiburg, Germany.
EM christian.offergeld@uniklinik-freiburg.de; jan.kromeier@rkk-sjk.de;
saumil_merchant@meei.harvard.edu;
nico.lasurashvili@uniklinikum-dresden.de;
marcus.neudert@uniklinikum-dresden.de;
matthias.bornitz@uniklinikum-dresden.de;
roland.laszig@uniklinik-freiburg.de;
thomas.zahnert@uniklinikum-dresden.de
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NR 33
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 191
EP 197
DI 10.1016/j.heares.2009.12.003
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700024
PM 19969056
ER
PT J
AU Lee, DH
Chan, S
Salisbury, C
Kim, N
Salisbury, K
Puria, S
Blevins, NH
AF Lee, Dong H.
Chan, Sonny
Salisbury, Curt
Kim, Namkeun
Salisbury, Kenneth
Puria, Sunil
Blevins, Nikolas H.
TI Reconstruction and exploration of virtual middle-ear models derived from
micro-CT datasets
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Microct; Middle ear; Otolaryngology; Volume rendering; Haptics; Otology
ID MALLEUS-INCUS COMPLEX; OSSICULAR CHAIN; ENDOSCOPY; IMAGES; BONE
AB Background: Middle-ear anatomy is integrally linked to both its normal function and its response to disease processes. Micro-CT imaging provides an opportunity to capture high-resolution anatomical data in a relatively quick and non-destructive manner. However, to optimally extract functionally relevant details, an intuitive means of reconstructing and interacting with these data is needed.
Materials and methods: A micro-CT scanner was used to obtain high-resolution scans of freshly explanted human temporal bones. An advanced volume renderer was adapted to enable real-time reconstruction, display, and manipulation of these volumetric datasets. A custom-designed user interface provided for semi-automated threshold segmentation. A 6-degrees-of-freedom navigation device was designed and fabricated to enable exploration of the 3D space in a manner intuitive to those comfortable with the use of a surgical microscope. Standard haptic devices were also incorporated to assist in navigation and exploration.
Results: Our visualization workstation could be adapted to allow for the effective exploration of middle-ear micro-CT datasets. Functionally significant anatomical details could be recognized and objective data could be extracted.
Conclusions: We have developed an intuitive, rapid, and effective means of exploring otological micro-CT datasets. This system may provide a foundation for additional work based on middle-ear anatomical data. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Lee, Dong H.; Puria, Sunil; Blevins, Nikolas H.] Stanford Univ, Dept Otolaryngol HNS, Stanford, CA 94305 USA.
[Salisbury, Curt; Kim, Namkeun; Puria, Sunil] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA.
[Chan, Sonny; Salisbury, Kenneth] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.
[Salisbury, Kenneth] Stanford Univ, Dept Gen Surg, Stanford, CA 94305 USA.
[Kim, Namkeun; Puria, Sunil] Palo Alto Vet Adm, Palo Alto, CA 94305 USA.
[Lee, Dong H.] Washington Univ, Sch Med, St Louis, MO 63130 USA.
RP Lee, DH (reprint author), Stanford Univ, Dept Otolaryngol HNS, Stanford, CA 94305 USA.
EM dhoonlee.biz+elsevier@gmail.com
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NR 17
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 198
EP 203
DI 10.1016/j.heares.2010.01.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700025
PM 20100558
ER
PT J
AU Homma, K
Shimizu, Y
Kim, N
Du, Y
Puria, S
AF Homma, Kenji
Shimizu, Yoshitaka
Kim, Namkeun
Du, Yu
Puria, Sunil
TI Effects of ear-canal pressurization on middle-ear bone- and
air-conduction responses
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
DE Bone conduction; Hearing protection; Middle-ear response; Middle-ear
dynamics; Ear-canal air pressure; Auditory biomechanics
ID SOUND FIELD; PRESSURE; HEARING; TRANSMISSION; THRESHOLDS; PARAMETERS;
MECHANICS; BEHAVIOR; MODEL
AB In extremely loud noise environments, it is important to not only protect one's hearing against noise transmitted through the air-conduction (AC) pathway, but also through the bone-conduction (BC) pathways. Much of the energy transmitted through the BC pathways is concentrated in the mid-frequency range around 1.5-2 kHz, which is likely due to the structural resonance of the middle ear. One potential approach for mitigating this mid-frequency BC noise transmission is to introduce a positive or negative static pressure in the ear canal, which is known to reduce BC as well as AC hearing sensitivity. In the present study, middle-ear ossicular velocities at the umbo and stapes were measured using human cadaver temporal bones in response to both BC and AC excitations, while static air pressures of +/- 400 mm H(2)O were applied in the ear canal. For the maximum negative pressure of -400 mm H(2)O, mean BC stapes-velocity reductions of about 5-8 dB were observed in the frequency range from 0.8 to 2.5 kHz, with a peak reduction of 8.6(+/- 4.7) dB at 1.6 kHz. Finite-element analysis indicates that the peak BC-response reduction tends to be in the mid-frequency range because the middle-ear BC resonance, which is typically around 1.5-2 kHz, is suppressed by the pressure-induced stiffening of the middle-ear structure. The measured data also show that the BC responses are reduced more for negative static pressures than for positive static pressures. This may be attributable to a difference in the distribution of the stiffening among the middle-ear components depending on the polarity of the static pressure. The characteristics of the BC-response reductions are found to be largely consistent with the available psychoacoustic data, and are therefore indicative of the relative importance of the middle-ear mechanism in BC hearing. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Homma, Kenji; Du, Yu] Adapt Technol Inc, Blacksburg, VA 24060 USA.
[Kim, Namkeun; Puria, Sunil] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA.
[Shimizu, Yoshitaka; Puria, Sunil] Stanford Univ, Dept Otolaryngol HNS, Stanford, CA 94305 USA.
[Shimizu, Yoshitaka; Puria, Sunil] Palo Alto Vet Adm, Palo Alto, CA 94305 USA.
RP Homma, K (reprint author), Adapt Technol Inc, 2020 Kraft Dr,Suite 3040, Blacksburg, VA 24060 USA.
EM kenji@adaptivetechinc.com
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NR 23
TC 13
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 204
EP 215
DI 10.1016/j.heares.2009.11.013
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700026
PM 19944139
ER
PT J
AU Weece, R
Allen, J
AF Weece, Reggie
Allen, Jont
TI A method for calibration of bone driver transducers to measure the
mastoid impedance
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
AB When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance mismatch, hence they fail to account for inter-subject variations of the energy transferred from the driver to the load. This study proposes a straightforward method for determining an absolute field calibration of a Radio Ear B71 bone driver, found by measuring the electrical input impedance of the transducer loaded by known masses. This absolute calibration is based upon a circuit model of the driver, describing it with three frequency-dependent parameters. Once these three parameters are known, measurements of the driver input voltage and current may be used to determine arbitrary mechanical load impedances (such as the in situ mastoid impedance), and thus the frequency dependence of the transmitted energy. The results of the proposed calibration method are validated by comparison with direct mechanical measurements using specialized equipment not available in the clinic, and a refined bone driver circuit model is proposed to better capture the observed behaviors. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Weece, Reggie] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA.
[Allen, Jont] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA.
RP Allen, J (reprint author), 2061 Beckman Inst, 405 N Mathews, Urbana, IL 61801 USA.
EM jontalle@illinois.edu
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NR 14
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 216
EP 223
DI 10.1016/j.heares.2010.02.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700027
PM 20193750
ER
PT J
AU Clavier, OH
Norris, JA
Dietz, AJ
AF Clavier, O. H.
Norris, J. A.
Dietz, A. J.
TI A comparison of the nonlinear response of the ear to air and to
bone-conducted sound
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Middle Ear Mechanics in Research and
Otology (MEMRO 2009)
CY JUN 24-28, 2009
CL Stanford, CA
HO Stanford Univ
ID PRODUCT OTOACOUSTIC EMISSION; INPUT/OUTPUT FUNCTIONS; HEARING
PROTECTION; CANCELLATION; CALIBRATION; ATTENUATION; LOUDNESS
AB The nonlinear response of the ear to air-conducted sound has been studied to some depth. However, the nonlinear response of the ear to bone-conducted sound has received less attention. A comparison of the nonlinear response of humans to air and bone-conducted sound is presented. Two different human subject test techniques were combined in this investigation. The first was a psychoacoustic investigation measuring the perceived cancellation of a bone-conducted sound stimulus with another air-conducted sound stimulus. The measurement was accomplished through a loudness-matching technique. The second investigation used distortion product otoacoustic emissions (DPOAEs) to make objective measurements of the response of the ear to both air-conducted sound and bone-conducted sound. The results were compared to determine whether the measured compression effects were similar for the different types of stimuli. Results show that both the measured psychoacoustic response and the measured objective response of the ear to air-conducted sound and to bone-conducted sound were similar at 2 and 4 kHz. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Clavier, O. H.; Norris, J. A.; Dietz, A. J.] Creare Res & Dev Inc, Hanover, NH 03755 USA.
RP Clavier, OH (reprint author), Creare Res & Dev Inc, POB 71, Hanover, NH 03755 USA.
EM ohc@creare.com
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NR 31
TC 2
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2010
VL 263
IS 1-2
SI SI
BP 224
EP 232
DI 10.1016/j.heares.2010.03.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 608KU
UT WOS:000278583700028
PM 20227477
ER
PT J
AU Drennan, WR
Won, JH
Nie, KB
Jameyson, E
Rubinstein, JT
AF Drennan, Ward R.
Won, Jong Ho
Nie, Kaibao
Jameyson, Elyse
Rubinstein, Jay T.
TI Sensitivity of psychophysical measures to signal processor modifications
in cochlear implant users
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Current steering; Spectral resolution; HiResolution;
Fidelity 120
ID NORMAL-HEARING; SPEECH RECOGNITION; HARMONIC COMPLEXES; RESOLUTION;
LISTENERS; DISCRIMINATION; NOISE; PITCH
AB Experienced users of the Clarion cochlear implant were tested acutely with the HiResolution (HiRes) and HiRes Fidelity120 (F120) processing strategies. Three psychophysically-based tests were used including spectral-ripple discrimination, Schroeder-phase discrimination and temporal modulation detection. Three clinical outcome measures were used including consonant-nucleus-consonant (CNC) word recognition in quiet, word recognition in noise and the clinical assessment of music perception (CAMP). Listener's spectral-ripple discrimination ability improved with F120, but Schroeder-phase discrimination was worse with F120 than with HiRes. Listeners who had better than average acuity showed the biggest effects. There were no significant effects of the processing strategy on any of the clinical abilities nor on temporal modulation detection. Additionally, the listeners' day-to-day clinical strategy did not appear to influence the result suggesting that experience with the strategies did not play a significant role. The results underscore the value of acoustic psychophysical measures through the sound processor as a tool in clinical research, because these measures are more sensitive to changes in the processing strategies than traditional clinical measures, e.g. speech understanding. The measures allow for the evaluation of sensitivity to specific acoustic attributes revealing the extent to which different processing strategies affect these basic abilities and could thus improve the efficiency of the development of processing strategies. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Drennan, Ward R.; Won, Jong Ho; Nie, Kaibao; Jameyson, Elyse; Rubinstein, Jay T.] Univ Washington, Dept Otolaryngol, VM Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
[Won, Jong Ho; Rubinstein, Jay T.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
RP Drennan, WR (reprint author), Univ Washington, Dept Otolaryngol, VM Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA.
EM drennan@u.washington.edu
FU NIH [R01-DC007525, F31-DC009755, P30-DC004661]; Advanced Bionics
Corporation
FX The authors are grateful for the dedicated efforts and sacrifice of all
of our listeners, for the helpful comments from three anonymous
reviewers and for the support of NIH grants R01-DC007525, F31-DC009755,
and P30-DC004661 and the Advanced Bionics Corporation. We also thank
Carlo Berenstein for providing some of his stimuli for analysis.
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TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2010
VL 262
IS 1-2
BP 1
EP 8
DI 10.1016/j.heares.2010.02.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 582IM
UT WOS:000276590400001
PM 20144699
ER
PT J
AU Hsieh, IH
Saberi, K
AF Hsieh, I-Hui
Saberi, Kourosh
TI Detection of sinusoidal amplitude modulation in logarithmic frequency
sweeps across wide regions of the spectrum
SO HEARING RESEARCH
LA English
DT Article
DE Psychoacoustics; Frequency sweep; FM; Modulation; Psychophysics
ID AUDITORY-CORTEX; MIXED MODULATION; SPEECH; DISCRIMINATION; SELECTIVITY;
PERCEPTION; SOUNDS; NOISE; LATERALIZATION; SENSITIVITY
AB Many natural sounds such as speech contain concurrent amplitude and frequency modulation (AM and FM), with the FM components often in the form of directional frequency sweeps or glides. Most studies of modulation coding, however, have employed one modulation type in stationary carriers, and in cases where mixed-modulation sounds have been used, the FM component has typically been confined to an extremely narrow range within a critical band. The current study examined the ability to detect AM signals carried by broad logarithmic frequency sweeps using a 2-alternative forced-choice adaptive psychophysical design. AM-detection thresholds were measured as a function of signal modulation rate and carrier sweep frequency region. Thresholds for detection of AM in a sweep carrier ranged from 8 dB for an AM rate of 8 Hz to -30 dB at 128 Hz. Compared to thresholds obtained for stationary carriers (pure tones and filtered Gaussian noise), detection of AM carried by frequency sweeps substantially declined at low (12 dB at 8 Hz) but not high modulation rates. Several trends in the data, including sweep- versus stationary-carrier threshold patterns and effects of frequency region were predicted from a modulation filterbank model with an envelope-correlation decision statistic. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Saberi, Kourosh] Univ Calif Irvine, Dept Cognit Sci, Irvine, CA 92697 USA.
[Saberi, Kourosh] Univ Calif Irvine, Ctr Cognit Neurosci, Irvine, CA 92697 USA.
[Hsieh, I-Hui] Natl Cent Univ, Inst Cognit Neurosci, Jhongli, Taiwan.
RP Saberi, K (reprint author), Univ Calif Irvine, Dept Cognit Sci, Irvine, CA 92697 USA.
EM saberi@uci.edu
FU National Science Council, Taiwan [NSC 98-2410-H-008-081-MY3]; NSF
[BCS0477984]; NIH [R01DC009659]
FX We thank Bruce G. Berg, Virginia Richards, Brian C. J. Moore, and two
anonymous reviewers for helpful comments. Work supported by grants from
the National Science Council, Taiwan NSC 98-2410-H-008-081-MY3, NSF
BCS0477984, and NIH R01DC009659.
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NR 58
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2010
VL 262
IS 1-2
BP 9
EP 18
DI 10.1016/j.heares.2010.02.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 582IM
UT WOS:000276590400002
PM 20144700
ER
PT J
AU Gabriel, DN
Munoz, DP
Boehnke, SE
AF Gabriel, Denise N.
Munoz, Douglas P.
Boehnke, Susan E.
TI The eccentricity effect for auditory saccadic reaction times is
independent of target frequency
SO HEARING RESEARCH
LA English
DT Article
DE Auditory saccade; Frequency; Eccentricity; Accuracy; Visual saccade
ID PRIMATE SUPERIOR COLLICULUS; FRONTAL EYE FIELDS; SOUND-PRESSURE LEVEL;
HEAD GAZE SHIFTS; RECEPTIVE-FIELDS; HORIZONTAL PLANE; GUIDED SACCADES;
HUMAN LISTENERS; LOCALIZATION; MOVEMENTS
AB Although much is understood about the stimulus properties affecting the latency of saccadic eye movements to visual targets, relatively little is known about the properties affecting saccades to auditory targets. This study examined the effect of three primary acoustic features-frequency, intensity, and spatial location-on auditory saccade characteristics in humans, and compared them to visual saccades. Saccade targets were presented from an azimuthal array of speakers and LEDs spanning +/- 36 degrees. There was an 'eccentricity effect' for auditory saccades such that latencies decreased by up to 70 ms with eccentricity. This was observed for all frequencies and intensities tested. There was a smaller effect in the opposite direction effect for visual saccades. Auditory saccades had similar latencies to visual saccades (within 5 ms) for near midline locations, but were up to 90 ms faster at eccentric locations (+/- 36 degrees). Overall, saccadic latencies were shortest for wideband noise and narrowband noises with center frequencies falling within the human speech range. Examination of saccade accuracy showed decreasing accuracy with increasing eccentricity, and a negative correlation between accuracy and latency for auditory stimuli. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Gabriel, Denise N.; Munoz, Douglas P.; Boehnke, Susan E.] Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, Canada.
[Munoz, Douglas P.] Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada.
[Munoz, Douglas P.] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
[Munoz, Douglas P.] Queens Univ, Dept Med, Kingston, ON K7L 3N6, Canada.
RP Boehnke, SE (reprint author), Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, Canada.
EM doug_munoz@biomed.queensu.ca; susan@bio-med.queensu.ca
FU Canadian Institutes of Health Research; Canada Research Chair Program
FX The authors thank Brian Liu, Donald Brien, Fred Paquin, and Sean Hickman
for technical assistance and the participants for their time. This
research was supported by the Canadian Institutes of Health Research (D.
P. Munoz) and the Canada Research Chair Program (D. P. Munoz).
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NR 65
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2010
VL 262
IS 1-2
BP 19
EP 25
DI 10.1016/j.heares.2010.01.016
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 582IM
UT WOS:000276590400003
PM 20138978
ER
PT J
AU Sayles, M
Winter, IM
AF Sayles, Mark
Winter, Ian M.
TI Equivalent-rectangular bandwidth of single units in the anaesthetized
guinea-pig ventral cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE Primary-like; Chopper; Onset; Cochlear nucleus; Guinea pig; Single unit;
Frequency-tuning; Equivalent-rectangular bandwidth
ID AUDITORY-NERVE FIBERS; CORTICAL RECEPTIVE-FIELDS; CROSSED OLIVOCOCHLEAR
BUNDLE; COMODULATION MASKING RELEASE; ITERATED RIPPLED NOISE; OUTER
HAIR-CELLS; BASILAR-MEMBRANE; TEMPORAL REPRESENTATION; CORTICOFUGAL
MODULATION; BACKGROUND-NOISE
AB Frequency-tuning is a fundamental property of auditory neurons. The filter bandwidth of peripheral auditory neurons determines the frequency resolution of an animal's auditory system. Behavioural studies in animals and humans have defined frequency-tuning in terms of the "equivalent-rectangular bandwidth" (ERB) of peripheral filters. In contrast, most physiological studies report the Q[best frequency/bandwidth] of frequency-tuning curves. This study aims to accurately describe the ERB of primary-like and chopper units in the ventral cochlear nucleus, the first brainstem processing station of the central auditory system. Recordings were made from 1020 isolated single units in the ventral cochlear nucleus of anesthetized guinea pigs in response to pure-tone stimuli which varied in frequency and in sound level. Frequency-threshold tuning curves were constructed for each unit and estimates of the ERB determined using methods previously described for auditory-nerve-fibre data in the same species. Primary-like, primary-notch, and sustained- and transient-chopper units showed frequency selectivity almost identical to that recorded in the auditory nerve. Their tuning at pure-tone threshold can be described as a function of best frequency (BF) by ERB = 0.31 * BF(0.5). (C) 2010 Elsevier B.V. All rights reserved.
C1 [Sayles, Mark; Winter, Ian M.] Univ Cambridge, Physiol Lab, Ctr Neural Basis Hearing, Cambridge CB2 3EG, England.
RP Sayles, M (reprint author), Univ Cambridge, Physiol Lab, Ctr Neural Basis Hearing, Downing St, Cambridge CB2 3EG, England.
EM sayles.m@gmail.com
FU Biotechnology and Biological Sciences Research Council; Frank Edward
Elmore fund; Leatherseller's Company, London
FX This work was funded by Grants to I.M.W. from the Biotechnology and
Biological Sciences Research Council. M.S. received financial support
from the Frank Edward Elmore fund of the Cambridge MB/PhD programme and
from the Leatherseller's Company, London.
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NR 93
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2010
VL 262
IS 1-2
BP 26
EP 33
DI 10.1016/j.heares.2010.01.015
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 582IM
UT WOS:000276590400004
PM 20123119
ER
PT J
AU Pratt, H
Starr, A
Michalewski, HJ
Dimitrijevic, A
Bleich, N
Mittelman, N
AF Pratt, Hillel
Starr, Arnold
Michalewski, Henry J.
Dimitrijevic, Andrew
Bleich, Naomi
Mittelman, Nomi
TI A comparison of auditory evoked potentials to acoustic beats and to
binaural beats
SO HEARING RESEARCH
LA English
DT Article
DE Event-related potentials; Steady-state; Hearing; Functional imaging
ID STEADY-STATE RESPONSES; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; SUPERIOR
OLIVARY COMPLEX; MIDDLE-LATENCY; BRAIN-STEM; INFERIOR COLLICULUS;
INTERACTION COMPONENTS; GUINEA-PIG; STIMULI; NEURONS
AB The purpose of this study was to compare cortical brain responses evoked by amplitude modulated acoustic beats of 3 and 6 Hz in tones of 250 and 1000 Hz with those evoked by their binaural beats counterparts in unmodulated tones to indicate whether the cortical processes involved differ.
Event-related potentials (ERPs) were recorded to 3- and 6-Hz acoustic and binaural beats in 2000 ms duration 250 and 1000 Hz tones presented with approximately 1 s intervals. Latency, amplitude and source current density estimates of ERP components to beats-evoked oscillations were determined and compared across beat types, beat frequencies and base (carrier) frequencies.
All stimuli evoked tone-onset components followed by oscillations corresponding to the beat frequency, and a subsequent tone-offset complex. Beats-evoked oscillations were higher in amplitude in response to acoustic than to binaural beats, to 250 than to 1000 Hz base frequency and to 3 Hz than to 6 Hz beat frequency. Sources of the beats-evoked oscillations across all stimulus conditions located mostly to left temporal lobe areas. Differences between estimated sources of potentials to acoustic and binaural beats were not significant.
The perceptions of binaural beats involve cortical activity that is not different than acoustic beats in distribution and in the effects of beat- and base frequency, indicating similar cortical processing. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Pratt, Hillel; Bleich, Naomi; Mittelman, Nomi] Technion Israel Inst Technol, Evoked Potentials Lab, IL-32000 Haifa, Israel.
[Starr, Arnold; Michalewski, Henry J.; Dimitrijevic, Andrew] Univ Calif Irvine, Neurol Res Lab, Irvine, CA 92697 USA.
RP Pratt, H (reprint author), Technion Israel Inst Technol, Evoked Potentials Lab, Gutwirth Bldg, IL-32000 Haifa, Israel.
EM hillel@tx.technion.ac.il
FU U.S.-Israel Binational Science Foundation; National Institutes of Health
[DC 02618]; Rappaport Family Institute
FX This study was partially supported by the U.S.-Israel Binational Science
Foundation, by Grant DC 02618 from the National Institutes of Health and
by the Rappaport Family Institute for Research in the Medical Sciences.
The authors thank Shi Pratt, a professional dancer who drew our
attention to the occurrence of binaural beats on stage.
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NR 62
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2010
VL 262
IS 1-2
BP 34
EP 44
DI 10.1016/j.heares.2010.01.013
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 582IM
UT WOS:000276590400005
PM 20123120
ER
PT J
AU Edds-Walton, PL
Holstein, GR
Fay, RR
AF Edds-Walton, Peggy L.
Holstein, Gay R.
Fay, Richard R.
TI Gamma-aminobutyric acid is a neurotransmitter in the auditory pathway of
oyster toadfish, Opsanus tau
SO HEARING RESEARCH
LA English
DT Article
DE Auditory processing; Descending octaval nucleus; Inhibition; Directional
hearing; Secondary octaval nucleus
ID DESCENDING OCTAVAL NUCLEUS; LATERAL-LINE LOBE; GABA-IMMUNOREACTIVE
NEURONS; INTERAURAL TIME DIFFERENCES; COMMON-MODE REJECTION; BRAIN-STEM;
GABAERGIC INHIBITION; INFERIOR COLLICULUS; DORSAL NUCLEUS; RAJA-ERINACEA
AB Binaural computations involving the convergence of excitatory and inhibitory inputs have been proposed to explain directional sharpening and frequency tuning documented in the brainstem of a teleost fish, the oyster toadfish (Opsanus tau). To assess the presence of inhibitory neurons in the ascending auditory circuit, we used a monoclonal antibody to GABA to evaluate immunoreactivity at three levels of the circuit: the first order descending octaval nucleus (DON), the secondary octaval population (dorsal division), and the midbrain torus semicircularis. We observed a subset of immunoreactive (IR) cells and puncta distributed throughout the neuropil at all three locations. To assess whether contralateral inhibition is present, fluorescent dextran crystals were inserted into dorsal DON to fill contralateral, commissural inputs retrogradely prior to GABA immunohistochemistry. GABA-IR somata and puncta co-occurred with retrogradely filled, GABA-negative auditory projection cells. GABA-IR projection cells were more common in the dorsolateral DON than in the dorsomedial DON, but GABA-IR puncta were common in both dorsolateral and dorsomedial divisions. Our findings demonstrate that GABA is present in the ascending auditory circuit in the brainstem of the toadfish, indicating that GABA-mediated inhibition participates in shaping auditory response characteristics in a teleost fish as in other vertebrates. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Edds-Walton, Peggy L.; Holstein, Gay R.; Fay, Richard R.] Marine Biol Lab, Inst Neurosci, Woods Hole, MA 02543 USA.
[Edds-Walton, Peggy L.; Fay, Richard R.] Loyola Univ, Parmly Hearing Inst, Chicago, IL 60626 USA.
[Holstein, Gay R.] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA.
[Holstein, Gay R.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA.
RP Edds-Walton, PL (reprint author), Marine Biol Lab, Inst Neurosci, 7 MBL St, Woods Hole, MA 02543 USA.
EM plewalton@yahoo.com
FU National Institute for Deafness and Other Communication Disorders
[DC006677, DC006215]
FX Louie Kerr and Blair Rossetti provided instruction on the use of the
Zeiss Axiolmager (Z1), and Becky MacDonald provided instruction in
photographing fluorescent images on the Z1 (at the Marine Biological
Laboratory). Rudi Rottenfusser obtained appropriate filters for the Z1
for use with the fluorophores chosen for this project. Jeff Johnson (and
members of the Federicci Lab) at UC Riverside graciously allowed PLEW to
use the Leica fluorescent microscope for tissue review and photography.
Dr. Ewa Kukielka and Rosemary Lang in the Martinelli-Holstein Lab
provided technical assistance in the initial experiments that produced
the successful protocol for the GABA immunohistochemistry. As has been
the case throughout the 14+ years of our research at the MBL, the
toadfish were obtained through the efforts of the excellent staff at the
Marine Resources Center. We also thank the colleagues who read and
contributed comments on an earlier version of this manuscript. This work
was funded by Grants from the National Institute for Deafness and Other
Communication Disorders: DC006677 (G.R.H.) and DC006215 (R.R.F.).
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NR 57
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2010
VL 262
IS 1-2
BP 45
EP 55
DI 10.1016/j.heares.2010.01.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 582IM
UT WOS:000276590400006
PM 20097279
ER
PT J
AU Schebesch, G
Lingner, A
Firzlaff, U
Wiegrebe, L
Grothe, B
AF Schebesch, Gabriele
Lingner, Andrea
Firzlaff, Uwe
Wiegrebe, Lutz
Grothe, Benedikt
TI Perception and neural representation of size-variant human vowels in the
Mongolian gerbil (Meriones unguiculatus)
SO HEARING RESEARCH
LA English
DT Article
DE Auditory-object recognition; Spectral processing; Superior olive;
Auditory midbrain; Auditory cortex; Speech; Vocal tract
ID PRIMARY AUDITORY-CORTEX; INFERIOR COLLICULUS; SPECTRAL INTEGRATION;
VOCAL-TRACT; CORTICAL RESPONSES; RECEPTIVE-FIELDS; SOUNDS; SELECTIVITY;
INHIBITION; CHINCHILLA
AB Humans reliably recognize spoken vowels despite the variability of the sounds caused by the across-subject variability of the speakers' vocal tract. The vocal tract serves as a resonator which imprints a spectral envelope onto the sounds generated by the vocal folds. This spectral envelope contains not only information about the type of vocalization but also about the size of the speaker: The larger the speaker, the lower the formant frequencies of the spoken vowels. In a combined psychophysical and electrophysiological study in the Mongolian gerbil (Meriones unguiculatus), we investigated the perception and neural representation of human vowels spoken by speakers of different sizes. Gerbils trained to discriminate two standard vowels, correctly assigned vowels spoken from different-sized human speakers. Complementary electrophysiological recordings from neurons in the auditory brainstem, midbrain, and primary auditory cortex show that the auditory brainstem retains a truthful representation of the frequency content of the presented vowel sounds. A small percentage of neurons in the midbrain and auditory cortex, however, showed selectivity for a certain vowel type or vocal tract length which is not related to the pure-tone, frequency response area, indicative of a preprocessing stage for auditory segregation of size and structure information. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Schebesch, Gabriele; Lingner, Andrea; Firzlaff, Uwe; Wiegrebe, Lutz; Grothe, Benedikt] Univ Munich, Div Neurobiol, Dept Biol 2, D-82152 Planegg Martinsried, Germany.
RP Grothe, B (reprint author), Univ Munich, Div Neurobiol, Dept Biol 2, Grosshadernerstr 2, D-82152 Planegg Martinsried, Germany.
EM schebesch@zi.biologie.uni-muenchen.de;
ling-ner@zi.biologie.uni-muenchen.de;
firzlaff@zi.biologie.uni-muenchen.de;
wiegrebe@zi.biologie.uni-muenchen.de; grothe@lmu.de
RI Grothe, Benedikt/A-7877-2010
FU Volkswagenstiftung [179/780, 179/782]
FX We thank Roy Patterson and David Smith for the provision of the
psychophysical and electrophysiological stimuli and many fruitful
discussions on the topic of auditory-object normalization. This work was
supported by a joint-project grant from the 'Volkswagenstiftung',
179/780 (to L.W.) and 179/782 (to B.G.).
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NR 32
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 1
EP 8
DI 10.1016/j.heares.2009.12.016
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200001
PM 20004713
ER
PT J
AU Gross, J
Stute, K
Moller, R
Fuchs, J
Amarjargal, N
Pohl, EE
Angerstein, M
Smorodchenko, A
Mazurek, B
AF Gross, Johann
Stute, Kerstin
Moller, Renate
Fuchs, Julia
Amarjargal, Nyamaa
Pohl, Elena E.
Angerstein, Maximilian
Smorodchenko, Alina
Mazurek, Birgit
TI Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti
during the postnatal period and in culture
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Development; Gene expression; Prestin; GATA; Thyroid hormone
ID OUTER HAIR-CELLS; ACTIVATED-RECEPTOR-ALPHA; TRANSCRIPTION FACTOR; MOTOR
PROTEIN; GENE-EXPRESSION; INNER-EAR; GATA3 HAPLOINSUFFICIENCY;
THYROID-HORMONE; HDR SYNDROME; DNA-BINDING
AB Based on observations that mutations of GATA-3 are responsible for the HDR-syndrome (hypoparathyroidism, deafness, renal defects) and that GATA-transcription factors have an important role to play in inner ear development, we hypothesized that these transcription factors may be involved in regulatory changes of prestin transcription. To prove this, we examined in parallel the expression of mRNA of prestin and Gata-3, -2 and Gata-1 in the organ of Corti during early postnatal development of rats and in organotypic cultures. Remarkable relations are observed between prestin and Gata-3, -2 expression in organ of Corti preparations in vivo and in vitro: (i) Gata-3, -2 expression display similar apical-basal gradients as prestin mRNA levels. (ii) The prestin expression increases between postnatal day two and postnatal day eight by a factor of about four in the apical and middle segments and by a factor of two in the basal part. Highly significant Pearson correlation coefficients were observed between Gata-3, -2 mRNA and prestin levels when the data were evaluated by regression analyses. (iii) Parallel changes of prestin mRNA and Gata-3, -2 mRNA levels were observed in response to thyroid hormone and to gemfibrozil application. These observations suggest a regulatory role played by the Gata-3, -2 transcription factors in prestin expression. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Gross, Johann; Stute, Kerstin; Moller, Renate; Fuchs, Julia; Amarjargal, Nyamaa; Pohl, Elena E.; Angerstein, Maximilian; Smorodchenko, Alina; Mazurek, Birgit] Charite, Mol Biol Res Lab, Dept Otorhinolaryngol, Inst Cell & Neurobiol, D-10117 Berlin, Germany.
RP Gross, J (reprint author), Charite, Mol Biol Res Lab, Dept Otorhinolaryngol, Inst Cell & Neurobiol, Charitepl 1, D-10117 Berlin, Germany.
EM johann.gross@charite.de; KerstinStute@web.de; renate.moller@charite.de;
julia.fuchs@charite.de; nyamaa.amra@charite.de; Elena.pohl@charite.de;
maximilian.angerstein@charite.de; Alina.smorodchaenko@charite.de;
Birgit.mazurek@charite.de
RI Pohl, Elena/A-4025-2009; Smorodchenko, Alina/D-1880-2010; Duncan,
Jeremy/K-7230-2013
OI Pohl, Elena/0000-0002-0604-5950; Duncan, Jeremy/0000-0002-5555-3273
FU University Hospital Charite; Sonnenfeld Stiftung
FX The data are part of the doctoral thesis of Kerstin Stute. The authors
thank Astrid Machulik for RT-PCR optimization. We also thank the
University Hospital Charite and the Sonnenfeld Stiftung (Prof. Dr.-Ing.
Hansjurgen Frhr. von Villiez, Berlin) for their financial support.
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NR 57
TC 7
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 9
EP 21
DI 10.1016/j.heares.2009.12.017
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200002
PM 20006695
ER
PT J
AU Strait, DL
Kraus, N
Parbery-Clark, A
Ashley, R
AF Strait, Dana L.
Kraus, Nina
Parbery-Clark, Alexandra
Ashley, Richard
TI Musical experience shapes top-down auditory mechanisms: Evidence from
masking and auditory attention performance
SO HEARING RESEARCH
LA English
DT Article
DE Musicians; Auditory; Backward masking; Perception; Brain; Corticofugal
ID SPEECH-IN-NOISE; BRAIN-STEM; NON-MUSICIANS; PROCESSING DISORDERS; PITCH
DISCRIMINATION; LANGUAGE IMPAIRMENT; TIMING DEFICITS; VERBAL MEMORY;
CHILDREN; NONMUSICIANS
AB A growing body of research suggests that cognitive functions, such as attention and memory, drive perception by tuning sensory mechanisms to relevant acoustic features. Long-term musical experience also modulates lower-level auditory function, although the mechanisms by which this occurs remain uncertain. In order to tease apart the mechanisms that drive perceptual enhancements in musicians, we posed the question: do well-developed cognitive abilities fine-tune auditory perception in a top-down fashion? We administered a standardized battery of perceptual and cognitive tests to adult musicians and non-musicians, including tasks either more or less susceptible to cognitive control (e.g., backward versus simultaneous masking) and more or less dependent on auditory or visual processing (e.g., auditory versus visual attention). Outcomes indicate lower perceptual thresholds in musicians specifically for auditory tasks that relate with cognitive abilities, such as backward masking and auditory attention. These enhancements were observed in the absence of group differences for the simultaneous masking and visual attention tasks. Our results suggest that long-term musical practice strengthens cognitive functions and that these functions benefit auditory skills. Musical training bolsters higher-level mechanisms that, when impaired, relate to language and literacy deficits. Thus, musical training may serve to lessen the impact of these deficits by strengthening the corticofugal system for hearing. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Strait, Dana L.; Kraus, Nina; Parbery-Clark, Alexandra] Northwestern Univ, Auditory Neurosci Lab, Evanston, IL 60208 USA.
[Strait, Dana L.; Ashley, Richard] Northwestern Univ, Bienen Sch Mus, Evanston, IL 60208 USA.
[Kraus, Nina; Parbery-Clark, Alexandra] Northwestern Univ, Dept Commun Sci, Evanston, IL 60208 USA.
[Kraus, Nina] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA.
[Kraus, Nina] Northwestern Univ, Dept Otolaryngol, Evanston, IL 60208 USA.
[Ashley, Richard] Northwestern Univ, Program Cognit Sci, Evanston, IL 60208 USA.
RP Strait, DL (reprint author), Northwestern Univ, Auditory Neurosci Lab, Frances Searle Bldg,2240 Campus Dr, Evanston, IL 60208 USA.
EM Dana.Strait@u.northwestern.edu; nkraus@northwestern.edu;
apc@northwestern.edu; r-ashley@northwestern.edu
RI Parbery-Clark, Alexandra/G-2966-2012
FU National Science Foundation [0544846]; Medical Research Council
FX This research was funded by the National Science Foundation Grant
0544846. The IMAP was developed by the Institute for Hearing Research
with a grant from the Medical Research Council.The authors thank Carolyn
Hsu for volunteering her assistance with data collection and subject
recruitment. We also thank David Moore, Erika Skoe, Trent Nicol and
Frederic Marmel for their contributions to the paper in its final stages
of preparation.
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NR 95
TC 79
Z9 81
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 22
EP 29
DI 10.1016/j.heares.2009.12.021
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200003
PM 20018234
ER
PT J
AU Pienkowski, M
Eggermont, JJ
AF Pienkowski, Martin
Eggermont, Jos J.
TI Intermittent exposure with moderate-level sound impairs central auditory
function of mature animals without concomitant hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE Auditory cortex; Plasticity; Passive sound exposure; Extracellular
recording; Single-unit activity; Local field potential; Receptive field;
Tonotopic map
ID RECEPTIVE-FIELDS; FREQUENCY REPRESENTATION; CORTEX; PLASTICITY;
ORGANIZATION; PERIOD; DISCRIMINATION; ENVIRONMENT; CATS; REORGANIZATION
AB Long-term, passive, continuous exposure of mature animals to moderate-level, band-limited sounds can profoundly decrease neural activity in primary auditory cortex (AI) to sounds in the exposure frequency range, and increase activity to sounds outside the exposure range. The resulting reorganization of the AI tonotopic map resembles that following a restricted lesion of the cochlear epithelium. Here we show qualitatively similar effects of passive exposure when it is limited to 12 h/day, simulating a noisy-work/quiet-living environment, albeit at substantially lower intensity levels (68 dB SPL) than are considered harmful to hearing. Compared to continuous exposure at the same SPL and over a similar duration (6-12 weeks), this intermittent exposure produced a smaller decrease in AI spike and LFP (local field potential) activity in response to sound frequencies in the exposure range, and an increase in activity only for frequencies above the exposure range. As expected at these exposure levels, cortical changes occurred in the absence of concomitant hearing loss (i.e., absolute threshold shifts). Our results have implications for occupational noise exposure standards, which presently may not prevent changes in central auditory function that cannot be detected on the standard behavioral audiogram. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Eggermont, Jos J.] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
Univ Calgary, Dept Pharmacol, Calgary, AB T2N 1N4, Canada.
Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM eggermon@ucalgary.ca
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NR 36
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 30
EP 35
DI 10.1016/j.heares.2009.12.025
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200004
PM 20036723
ER
PT J
AU Willott, JF
VandenBosche, J
Shimizu, T
AF Willott, James F.
VandenBosche, Justine
Shimizu, Toru
TI Effects of a high-frequency augmented acoustic environment on
parvalbumin immunolabeling in the anteroventral cochlear nucleus of
DBA/2J and C57BL/6J mice
SO HEARING RESEARCH
LA English
DT Article
DE Mice; Sensorineural hearing loss; Augmented acoustic environment;
Cochlear nucleus; Parvalbumin
ID AUDITORY BRAIN-STEM; BINDING PROTEIN IMMUNOREACTIVITY; SENSORINEURAL
HEARING-LOSS; INFERIOR COLLICULUS; PREPULSE INHIBITION; RESPONSE
THRESHOLDS; PROLONGED EXPOSURE; GONADAL-HORMONES; MOUSE; NEURONS
AB Neurons in the anteroventral cochlear nucleus (AVCN) of DBA/2J (D2) and C57BL/6J (B6) mice were immunohistochemically labeled for the calcium binding protein parvalbumin (PV). Prior to this, mice were treated for 12 h nightly with a "high-frequency" augmented acoustic environment (HAAE: repetitive bursts of a 70 dB sound pressure level, half-octave noise band centered at 20 kHz). This was done during the period that hearing loss occurs: pre-weaning to 55 days in D2 mice and weaning to 9 months in B6 mice. After HAAE treatment in D2 mice, high-frequency hearing loss was ameliorated and fewer PV-labeled neurons were found in the AVCN compared to untreated controls. HAAE treatment in B6 mice exacerbated high-frequency hearing loss, yet the number of PV-labeled AVCN neurons in treated mice did not differ significantly from that of control mice. The findings suggest that HAAE treatment provides relief from physiological stress caused by deprivation of auditory input from the impaired cochlea. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Willott, James F.; VandenBosche, Justine; Shimizu, Toru] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA.
RP Willott, JF (reprint author), Univ S Florida, Dept Psychol, 4202 E Fowler Ave,PCD4118G, Tampa, FL 33620 USA.
EM jimw@niu.edu
FU National Institute on Aging [R01 AG07554]
FX This research was supported by R01 AG07554 (J.F.W.). Thanks to Drs.
Sandra McFadden and Francisco Gonzales-Lima for helpful comments. I have
now retired, and this is the last research paper I will publish. I am
grateful to Hearing Research for publishing so many of my papers (27)
over the years, to a host of students and colleagues I collaborated
with, and to the National Institute on Aging, which has supported my
work for 29 years. It's been great!
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NR 38
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 36
EP 41
DI 10.1016/j.heares.2009.12.029
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200005
PM 20060461
ER
PT J
AU Van Trump, WJ
Coombs, S
Duncan, K
McHenry, MJ
AF Van Trump, William J.
Coombs, Sheryl
Duncan, Kyle
McHenry, Matthew J.
TI Gentamicin is ototoxic to all hair cells in the fish lateral line system
SO HEARING RESEARCH
LA English
DT Article
DE Aminoglycoside antibiotics; DASPEI; FM1-43
ID BLIND CAVE FISH; ZEBRAFISH DANIO-RERIO; ANOPTICHTHYS-JORDANI CHARACIDAE;
ANEMONE REPAIR PROTEINS; AMINOGLYCOSIDE ANTIBIOTICS; POSTEMBRYONIC
DEVELOPMENT; STATIONARY OBJECTS; RAINBOW-TROUT; SENSORY CELLS; DEATH
AB Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology of hair cells between the two classes of neuromast. Studies concerned with the individual roles of canal and superficial neuromasts in behavior have taken advantage of this effect in an attempt to selectively disable canal neuromasts without affecting superficial neuromast function. Here we present an experimental test of the hypothesis that canal neuromasts are more vulnerable to gentamicin than superficial neuromasts. We measured the effect of gentamicin exposure on hair cells using vital stains (DASPEI and FM1-43) in the neuromasts of Mexican blind cave fish (Astyanax fasciatus) and zebrafish (Danio rerio). Contrary to the findings of prior studies that used SEM, gentamicin significantly reduced dye uptake by hair cells of both canal and superficial neuromasts in both species. Therefore, lateral line hair cells of both neuromast types are vulnerable to gentamicin ototoxicity. These findings argue for a re-evaluation of the results of studies that have used gentamicin to differentiate the roles of the two classes of neuromast in fish behavior. Published by Elsevier B.V.
C1 [Van Trump, William J.; McHenry, Matthew J.] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA.
[Coombs, Sheryl; Duncan, Kyle] Bowling Green State Univ, Dept Biol Sci, JP Scott Ctr Neurosci Mind & Behav, Bowling Green, OH 43403 USA.
RP Van Trump, WJ (reprint author), Univ Calif Irvine, Dept Ecol & Evolutionary Biol, 321 Steinhaus Hall, Irvine, CA 92697 USA.
EM wvantrum@uci.edu
FU NSF [IOS-0723288, IOB-0509740]
FX We thank Dr. E. Rubel and his research group for advice, Tristan Ula and
Ashley Hammer for support with animal care, and Dr. A.P. Summers for
lending equipment. MJM's research was supported by grants from the NSF
(IOS-0723288 and IOB-0509740).
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NR 50
TC 27
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 42
EP 50
DI 10.1016/j.heares.2010.01.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200006
PM 20060460
ER
PT J
AU Moore, BCJ
Vinay
Sandhya
AF Moore, Brian C. J.
Vinay
Sandhya
TI The relationship between tinnitus pitch and the edge frequency of the
audiogram in individuals with hearing impairment and tonal tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE Tinnitus; Pitch; Edge frequency
ID AUDITORY-CORTEX; DEAD REGIONS; LOUDNESS; COCHLEA; PLASTICITY;
MECHANISMS; DIAGNOSIS; ADULT
AB Some theories of mechanisms of tinnitus generation lead to the prediction that the pitch associated with tonal tinnitus should be related to the "edge frequency" of the audiogram, f(e), the frequency at which hearing loss worsens relatively abruptly. However, previous studies testing this prediction have provided little or no support for it. Here, we reexamined the relationship between tinnitus pitch and f(e), using 11 subjects selected to have mild-to-moderate hearing loss and tonal tinnitus. Subjects were asked to compare the pitch of their tinnitus to that of a sinusoidal tone whose frequency and level were adjusted by the experimenter. Prior to testing in the main experiment, subjects were given specific training to help them to avoid octave errors in their pitch matches. Pitch matches made after this training were generally lower in frequency than matches made before such training, often by one or two octaves. The matches following training were highly reproducible. A clear relationship was found between the values of f(e) and the mean pitch matches following training; the correlation was 0.94. Generally, the pitch matches were close in value to the values of f(e). (C) 2010 Elsevier B.V. All rights reserved.
C1 [Moore, Brian C. J.] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
[Vinay; Sandhya] All India Inst Speech & Hearing, Mysore 570006, Karnataka, India.
RP Moore, BCJ (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England.
EM bcjm@cam.ac.uk
RI Moore, Brian/I-5541-2012
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NR 31
TC 26
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 51
EP 56
DI 10.1016/j.heares.2010.01.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200007
PM 20103482
ER
PT J
AU Kimitsuki, T
Komune, N
Noda, T
Takaiwa, K
Ohashi, M
Komune, S
AF Kimitsuki, Takashi
Komune, Noritaka
Noda, Teppei
Takaiwa, Kazutaka
Ohashi, Mitsuru
Komune, Shizuo
TI Property of I-K,I-n in inner hair cells isolated from guinea-pig cochlea
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Inner hair cell; Potassium currents; KCNQ-channel; Linopirdine;
XE991
ID HEARING-LOSS; POTASSIUM CURRENTS; DOMINANT DEAFNESS; MOUSE COCHLEA;
KCNQ4 GENE; CHANNEL; EXPRESSION; SUBUNITS; FAMILY; MICE
AB One of the potassium currents, I-K,I-n, is already activated at the resting potential of the cell and thus determines the membrane potential. KCNQ4 channel has been identified as the molecular correlate of I-K,I-n. In the present study, we measured I-K,I-n in acutely isolated IHCs of guinea-pig cochlea using the whole-cell voltage-clamp techniques, and investigated the properties of the currents. I-K,I-n was 70% activated around the resting potential of -60 mV and deactivated on hyperpolarization. I-K,I-n was blocked by the KCNQ-channel blockers, linopirdine (100 mu M) and XE991 (10 mu M), but was insensitive to both I-K,I-f blocker, tetraethylammonium (TEA), and I-K,I-s blocker, 4-aminopyridine (4-AP). There was no significant difference in the size of I-K,I-n between the apical and basal turn IHCs. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Kimitsuki, Takashi; Komune, Noritaka; Noda, Teppei; Takaiwa, Kazutaka; Ohashi, Mitsuru; Komune, Shizuo] Kyushu Univ, Dept Otolaryngol, Grad Sch Med Sci, Fac Med,Higashi Ku, Fukuoka 8128582, Japan.
RP Kimitsuki, T (reprint author), Kyushu Univ, Dept Otolaryngol, Grad Sch Med Sci, Fac Med,Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM kimitaka@qentmed.kyushu-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
[9591978, 21592160]; Research Fund of Institute of Kampo Medicine
(Japan)
FX This work was supported by a Grant-in-Aid for Scientific Research
9591978, 21592160 from the Ministry of Education, Culture, Sports,
Science and Technology of Japan and the Research Fund of Institute of
Kampo Medicine (Japan).
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NR 29
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 57
EP 62
DI 10.1016/j.heares.2010.01.002
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200008
PM 20060884
ER
PT J
AU MacDonald, EN
Pichora-Fuller, MK
Schneider, BA
AF MacDonald, Ewen N.
Pichora-Fuller, M. Kathleen
Schneider, Bruce A.
TI Effects on speech intelligibility of temporal jittering and spectral
smearing of the high-frequency components of speech
SO HEARING RESEARCH
LA English
DT Article
DE Temporal jitter; Spectral smearing; Speech intelligibility; Word
identification
ID FINE-STRUCTURE CUES; AUDITORY-PERCEPTION; HEARING-LOSS; ENVELOPE;
TRANSFORM; RECEPTION; SENTENCES; MASKING; NOISE
AB In a previous study, we demonstrated that word recognition performance was reduced when the low-frequency components of speech (0-1.2 kHz)were distorted by temporal uttering, but not when they were distorted by spectral smearing (Pichora-Fuller et al., 2007). Temporal uttering distorts the fine structure of the speech signal with negligible alteration of either its long-term spectral or amplitude envelope characteristics. Spectral smearing simulates the effects of broadened auditory filters that occur with cochlear hearing loss (Baer and Moore, 1993). In the present study, the high-frequency components of speech (1.2-7 kHz) were distorted with uttering and smearing. Word recognition in noise for both distortion conditions was poorer than in the intact condition. However, unlike our previous study, no significant difference was found in word recognition performance in the two distorted conditions. Whereas temporal distortion seems to have a deleterious effect that cannot be attributed to spectral distortion when only the lower frequencies are distorted, when the higher frequencies are distorted both temporal and spectral distortion reduce speech intelligibility. (C) 2010 Elsevier B.V. All rights reserved.
C1 [MacDonald, Ewen N.] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada.
[MacDonald, Ewen N.] Univ Toronto, Dept Elect & Comp Engn, Toronto, ON M5S 3G4, Canada.
[MacDonald, Ewen N.; Pichora-Fuller, M. Kathleen] Toronto Rehabil Inst, Toronto, ON M5G 2A2, Canada.
[Pichora-Fuller, M. Kathleen; Schneider, Bruce A.] Univ Toronto, Dept Psychology, Mississauga, ON L5L 1C6, Canada.
RP MacDonald, EN (reprint author), Queens Univ, Dept Psychol, Humphrey Hall,62 Arch St, Kingston, ON K7L 3N6, Canada.
EM ewen.macdonald@utoronto.ca; k.pichora.fuller@utoronto.ca
RI MacDonald, Ewen/B-8841-2013
FU Natural Sciences and Engineering Research Council of Canada [RGPIN
138572-05]; Canadian Institutes of Health Research [MOP-15359]
FX This research was funded by the Natural Sciences and Engineering
Research Council of Canada (RGPIN 138572-05; Pichora-Fuller) and the
Canadian Institutes of Health Research(MOP-15359; Schneider and
Pichora-Fuller). The authors thank Lesley Filmer and Christine DeLuca
for assistance in conducting the experiment.
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NR 25
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 63
EP 66
DI 10.1016/j.heares.2010.01.005
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200009
PM 20093174
ER
PT J
AU Nakamagoe, M
Tabuchi, K
Uemaetomari, I
Nishimura, B
Hara, A
AF Nakamagoe, Mariko
Tabuchi, Keiji
Uemaetomari, Isao
Nishimura, Bungo
Hara, Akira
TI Estradiol protects the cochlea against gentamicin ototoxicity through
inhibition of the JNK pathway
SO HEARING RESEARCH
LA English
DT Article
DE Gentamicin; c-jun N-terminal kinase (JNK); 17 beta-Estradiol (E2); Hair
cell; Organ of Corti
ID DEVELOPING PURKINJE-CELL; HAIR-CELLS; AMINOGLYCOSIDE ANTIBIOTICS;
OTOACOUSTIC EMISSIONS; DENDRITIC GROWTH; ACOUSTIC TRAUMA; IN-VITRO;
ESTROGEN; ORGAN; DAMAGE
AB Gentamicin induces outer hair cell death through the apoptotic pathway. It has been reported that this death pathway of outer hair cells is mediated by specific apoptotic enzymes including c-jun N-terminal kinase (JNK) and caspases. 17 beta-Estradiol (E2), the most potent estrogen, is known to function as an antiapoptotic agent to prevent the death of various cell types. The purpose of the present study was to examine the effects of E2 on gentamicin-induced apoptotic cell death in outer hair cells. The basal turn organ of Corti explants from p3 or p4 rats were maintained in a tissue culture and exposed to 100 mu M gentamicin for 48 h. The effects of E2 on gentamicin-induced outer hair cell loss, JNK activation, and staining for terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick-end labeling (TUNEL) were examined. E2 significantly decreased gentamicin-induced outer hair cell loss in a dose-dependent manner. JNK activation and TUNEL staining were observed in organ of Corti explants exposed to gentamicin, and staining levels were significantly decreased by E2 treatment. The results indicate that, through the inhibition of JNK and subsequent apoptotic reactions, E2 decreases outer hair cell loss induced by gentamicin ototoxicity. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Nakamagoe, Mariko; Tabuchi, Keiji; Uemaetomari, Isao; Nishimura, Bungo; Hara, Akira] Univ Tsukuba, Dept Otolaryngol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan.
RP Tabuchi, K (reprint author), Univ Tsukuba, Dept Otolaryngol, Grad Sch Comprehens Human Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM ktabuchi@md.tsukuba.ac.jp
FU Japan's the Ministry of Education, Culture, Sports, Science, and
Technology [20591969]
FX This work was supported by a Grant-in-aid for Scientific Research (C)
20591969 from Japan's the Ministry of Education, Culture, Sports,
Science, and Technology.
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NR 37
TC 15
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 67
EP 74
DI 10.1016/j.heares.2010.01.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200010
PM 20074632
ER
PT J
AU Fowler, CG
Chiasson, KB
Leslie, TH
Thomas, D
Beasley, TM
Kemnitz, JW
Weindruch, R
AF Fowler, Cynthia G.
Chiasson, Kirstin Beach
Leslie, Tami Hanson
Thomas, Denise
Beasley, T. Mark
Kemnitz, Joseph W.
Weindruch, Richard
TI Auditory function in rhesus monkeys: Effects of aging and caloric
restriction in the Wisconsin monkeys five years later
SO HEARING RESEARCH
LA English
DT Article
DE Hearing; Aging; Presbycusis; Age-related hearing loss; Monkeys;
Otoacoustic emissions (OAE); Caloric restriction (diet restriction);
Auditory brainstem response (ABR)
ID PRODUCT OTOACOUSTIC EMISSIONS; UNIVERSITY-OF-WISCONSIN; DIETARY
RESTRICTION; MACACA-MULATTA; HEARING-LOSS; COCHLEAR PATHOLOGY;
EVOKED-RESPONSE; AGE; PRESBYCUSIS; THRESHOLDS
AB Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studying the effects of CR in aging and ARHL Subjects were from the pool of 55 rhesus monkeys aged 15-28 years who had been in the Wisconsin study on CR and aging for 8-13.5 years. Distortion product otoacoustic emissions (DPOAE) with 12 frequencies from 2211 to 8837 Hz and auditory brainstem response (ABR) thresholds from clicks and 8, 16, and 32 kHz tone bursts were obtained. DPOAE levels declined linearly at approximately 1 dB/year, but that rate doubled for the highest frequencies in the oldest monkeys. There were no interactions for diet condition or sex. ABR thresholds to clicks and tone bursts showed increases with aging. Borderline significance was shown for diet in the thresholds at 8 kHz stimuli, with monkeys on caloric restriction having lower thresholds. Because the rhesus monkeys have a maximum longevity of 40 years, the full benefits of CR may not yet be realized. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Fowler, Cynthia G.] Univ Wisconsin, Dept Commun Disorders, Madison, WI 53706 USA.
[Chiasson, Kirstin Beach] Nationwide Childrens Hosp, Columbus, OH 43205 USA.
[Leslie, Tami Hanson] Greater Milwaukee Otolaryngol LLC, Greenfield, WI 53220 USA.
[Thomas, Denise] Childrens Mem Hosp, Chicago, IL 60614 USA.
[Beasley, T. Mark] Univ Alabama, Dept Biostat, Sch Publ Hlth, Birmingham, AL 35294 USA.
[Kemnitz, Joseph W.] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Physiol, Madison, WI 53715 USA.
[Weindruch, Richard] Univ Wisconsin, Dept Med, William S Middleton Mem Vet Hosp, Madison, WI 53705 USA.
RP Fowler, CG (reprint author), Univ Wisconsin, Dept Commun Disorders, 1975 Willow Dr, Madison, WI 53706 USA.
EM cgfowler@wisc.edu; Kirstin.Chiasson@nationwidechildrens.org;
tamil@gmodocs.com; DThomas@childrensmemorial.org;
mbeasley@ms.soph.uab.edu; kemnitz@primate.wisc.edu; rhweindr@wisc.edu
FU NIH [P01 AG11915]; National Primate Research Center [RR000167]
FX This work was supported in part by NIH P01 AG11915. The Wisconsin
National Primate Research Center is supported in part by NIH Grant
RR000167. The authors would like to thank Scott Baum for assistance with
the animals, and two anonymous reviewers for comments on an earlier
version of this paper. Portions of these data were presented at the
International Evoked Response Audiometry Study Group, Havana, Cuba,
2005.
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NR 40
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2010
VL 261
IS 1-2
BP 75
EP 81
DI 10.1016/j.heares.2010.01.006
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 577AV
UT WOS:000276193200011
PM 20079820
ER
PT J
AU Seeber, BU
Kerber, S
Hafter, ER
AF Seeber, Bernhard U.
Kerber, Stefan
Hafter, Ervin R.
TI A system to simulate and reproduce audio-visual environments for spatial
hearing research
SO HEARING RESEARCH
LA English
DT Article
DE Binaural hearing; Virtual acoustics; Auralization; Audio-visual
interaction; Hearing impairment; Room simulation
ID BILATERAL COCHLEAR IMPLANTS; BOX LOUDSPEAKER SYSTEMS; LOCALIZATION;
MODEL
AB The article reports the experience gained from two implementations of the "Simulated Open-Field Environment" (SOFE), a setup that allows sounds to be played at calibrated levels over a wide frequency range from multiple loudspeakers in an anechoic chamber. Playing sounds from loudspeakers in the free-field has the advantage that each participant listens with their own ears, and individual characteristics of the ears are captured in the sound they hear. This makes an easy and accurate comparison between various listeners with and without hearing devices possible. The SOFE uses custom calibration software to assure individual equalization of each loudspeaker. Room simulation software creates the spatio-temporal reflection pattern of sound sources in rooms which is played via the SOFE loudspeakers. The sound playback system is complemented by a video projection facility which can be used to collect or give feedback or to study auditory-visual interaction. The article discusses acoustical and technical requirements for accurate sound playback against the specific needs in hearing research. An introduction to software concepts is given which allow easy, high-level control of the setup and thus fast experimental development, turning the SOFE into a "Swiss army knife" tool for auditory, spatial hearing and audio-visual research. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
C1 [Seeber, Bernhard U.; Kerber, Stefan] MRC Inst Hearing Res, Nottingham NG7 2RD, England.
[Seeber, Bernhard U.; Hafter, Ervin R.] Univ Calif Berkeley, Dept Psychol, Auditory Percept Lab, Berkeley, CA 94530 USA.
RP Seeber, BU (reprint author), MRC Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England.
EM seeber@ihr.mrc.ac.uk; stefan@ihr.mrc.ac.uk; hafter@berkeley.edu
FU NIH NIDCD [00087]; Medical Research Council (UK, Nottingham)
FX We would like to thank the many who helped creating the two setups.
These are the members of the electrical workshop of the Psychology
Department at the University Berkeley: Ted Crum, Steve Lones, Eric
Eichorn and of the mechanical workshop: Edward Claire. At the MRC
Institute of Hearing Research these are: Dave Bullock, John Chambers,
Marc Reeve, Cameron Shaw, Mike Kasili, Dr. Andrew Sidwell, Andrew Lavens
from the electrical, mechanical and computer workshops and Dr. Victor
Chilekwa and Damon McCartney for help with programming the visual
environment.This work was supported by NIH NIDCD 00087 (Berkeley) and by
the intramural programme of the Medical Research Council (UK,
Nottingham).
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NR 33
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2009.11.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400001
PM 19909802
ER
PT J
AU Nishioka, R
Takeda, T
Kakigi, A
Okada, T
Takebayashi, S
Taguchi, D
Nishimura, M
Hyodo, M
AF Nishioka, R.
Takeda, T.
Kakigi, A.
Okada, T.
Takebayashi, S.
Taguchi, D.
Nishimura, M.
Hyodo, M.
TI Expression of aquaporins and vasopressin type 2 receptor in the stria
vascularis of the cochlea
SO HEARING RESEARCH
LA English
DT Article
DE AQPs; V2-R; Water homeostasis; Stria vascularis; Gap junction; Na-K-CI
cotransporter
ID K-CL COTRANSPORTER; RAT INNER-EAR; WATER CHANNEL PROTEIN; ENDOLYMPHATIC
SAC; GUINEA-PIG; IMMUNOHISTOCHEMICAL LOCALIZATION; TRANSPORT;
IMMUNOLOCALIZATION; PERMEABILITY; HOMEOSTASIS
AB Recently, considerable evidence has been accumulated to support the novel view that water homeostasis in the inner ear is regulated via the vasopressin-aquaporin 2 (VP-AQP2) system in the same fashion as in the kidney. Indeed, multiple subtypes of AQPs including AQP-2 are reported to be expressed in the cochlea. However, the mechanism that underlies VP-AQP-2 mediated water homeostasis remains to be elucidated. In the present study, the localizations of AQP-1, -2,-3,-4, -5, -7, -8, -9, and vasopressin type 2 receptor (V2-R) in the stria vascularis (SV) were molecular biologically and immunohistochemically examined to evaluate the role of the AQP water channel system in water homeostasis of the SV. A RTPCR study revealed that AQPs and V2-R mRNA are expressed in the cochlea. As for their immunohistochemical localization, the AQP-2 protein is expressed on the basal side of the basal cells of the SV, and proteins of AQP-3 and V2-R are expressed on the apical side of the basal cells. AQP-7 and -9 proteins are expressed on the apical side of marginal cells. AQP-4, -5, and -8 protein expressions could not be detected in the lateral wall of the cochlea. From the present results, water flux in the SV is thought to be regulated at the level of the basal cells by vasopressin. Furthermore, such a distribution of AQP-2, 3, and V2-R suggests that VP-AQP-2 mediated water transport might work actively in the basal cells from perilymph towards endolymph containing AQP-1, -7 and -9. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Nishioka, R.; Takeda, T.; Kakigi, A.; Hyodo, M.] Kochi Med Sch, Dept Otolaryngol Head & Neck Surg, Kochi 7838505, Japan.
[Okada, T.] Kochi Med Sch, Dept Anat, Kochi 7838505, Japan.
[Takebayashi, S.] Japanese Red Cross Wakayama Med Ctr, Dept Otolaryngol, Wakayama, Japan.
[Taguchi, D.] Tottori Univ, Div Otolaryngol Head & Neck Surg, Tottori 680, Japan.
[Nishimura, M.] Osaka Univ, Dept Otolaryngol, Grad Sch Med, Osaka, Japan.
RP Nishioka, R (reprint author), Kochi Med Sch, Dept Otolaryngol, Nanko Ku, Oko Cho, Kochi 7838505, Japan.
EM rnishioka@kochi-u.ac.jp
FU Ministry of Education, Culture, Sports, and Technology of Japan
[20591987]; Ministry of Health, Labor, and Welfare of Japan
FX We thank Ms. Aya Uchida for her technical assistant. This study was
supported by a Grant-in Aid for Scientific Research (C) from the
Ministry of Education, Culture, Sports, and Technology of Japan (No.
20591987), and a Health and Labor Science Research Grant for Research on
Specific Disease (Vestibular Disorders) from the Ministry of Health,
Labor, and Welfare of Japan (2007).
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NR 45
TC 11
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 11
EP 19
DI 10.1016/j.heares.2009.09.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400002
PM 19796672
ER
PT J
AU Stronks, HC
Aarts, MCJ
Klis, SFL
AF Stronks, H. Christiaan
Aarts, Mark C. J.
Klis, Sjaak F. L.
TI Effects of isoflurane on auditory evoked potentials in the cochlea and
brainstem of guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE Isoflurane; Guinea pig; Compound action potential; Cochlear
microphonics; Auditory brainstem response
ID MIDDLE-EAR PRESSURE; NITROUS-OXIDE ANESTHESIA; ELECTROPHYSIOLOGICAL
EVIDENCE; SYNAPTIC-TRANSMISSION; NOXIOUS-STIMULATION; NMDA RECEPTORS;
RESPONSES; PROPOFOL; HUMANS; NERVE
AB Electrophysiological recordings of the auditory system are commonly performed in deeply anesthetized animals. This study evaluated the effects of various concentrations of the volatile anesthetic isoflurane (1-3%) on the compound action potential (CAP), cochlear microphonic (CM) and auditory brainstem response (ABR). Recordings were initiated in the awake, lightly restrained animal. Anesthesia was induced with a single dose of Hypnorm (R) (fentanyl and fluanisone). After tracheostomy increasing isoflurane concentrations were applied in N(2)O/O(2) Via controlled ventilation. Data were compared to recordings in the awake animal using repeated measures ANOVA and Dunnett's post hoc test. On average, isoflurane dose-dependently suppressed the amplitude and increased the latency of the CAP. CM amplitude was suppressed. These effects were most profound at high frequencies and were typically significant at isoflurane concentrations of 2.5% and 3%. Amplitude and latency of the second negative peak of the CAP (N(2)) were affected to a greater extent compared to the first peak (N(1)). On average, isoflurane dose-dependently reduced the amplitude and increased the latency of the ABR. These effects were typically significant at an isoflurane concentration of 2%. Effects on peak IV and V were more pronounced compared to the early peaks I and III. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Stronks, H. Christiaan; Aarts, Mark C. J.; Klis, Sjaak F. L.] Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands.
RP Klis, SFL (reprint author), Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Rudolf Magnus Inst Neurosci, Heidelberglaan 100,Room G-02-531,POB 85500, NL-3584 CX Utrecht, Netherlands.
EM c.stronks@umcutrecht.nl; m.aarts2@umcu-trecht.nl; s.Klis@umcutrecht.nl
FU Heinsius-Houbolt fund, Wassenaar, The Netherlands
FX This work was funded by the Heinsius-Houbolt fund, Wassenaar, The
Netherlands.The authors wish to thank Rik Mansvelt-Beck and Josine
Verhaal for technical assistance and are grateful to Rene van de Vosse
for data acquisition and analysis software and technical assistance.
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NR 57
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 20
EP 29
DI 10.1016/j.heares.2009.10.015
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400003
PM 19878711
ER
PT J
AU Zhang, PX
Hartmann, WM
AF Zhang, Peter Xinya
Hartmann, William M.
TI On the ability of human listeners to distinguish between front and back
SO HEARING RESEARCH
LA English
DT Article
DE Localization; Front/back; Human; Simulation; Transaural; Localization
bands
ID HUMAN SOUND LOCALIZATION; MEDIAN PLANE LOCALIZATION; DORSAL COCHLEAR
NUCLEUS; MONAURAL SPECTRAL CUES; HEADPHONE SIMULATION; SAGITTAL PLANE;
VERTICAL-PLANE; LATERAL ANGLE; NARROW-BAND; PINNA CUES
AB In order to determine whether a sound source is in front or in back, listeners can use location-dependent spectral cues caused by diffraction from their anatomy. This capability was studied using a precise virtual reality technique (VRX) based on a transaural technology. Presented with a virtual baseline simulation accurate up to 16 kHz, listeners could not distinguish between the simulation and a real source. Experiments requiring listeners to discriminate between front and back locations were performed using controlled modifications of the baseline simulation to test hypotheses about the important spectral cues. The experiments concluded: (1) Front/back cues were not confined to any particular 1/3rd or 2/3rd octave frequency region. Often adequate cues were available in any of several disjoint frequency regions. (2) Spectral dips were more important than spectral peaks. (3) Neither monaural cues nor interaural spectral level difference cues were adequate. (4) Replacing baseline spectra by sharpened spectra had minimal effect on discrimination performance. (5) When presented with an interaural time difference less than 200 mu s, which pulled the image to the side, listeners still successfully discriminated between front and back, suggesting that front/back discrimination is independent of azimuthal localization within certain limits. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Zhang, Peter Xinya] Columbia Coll Chicago, Dept Audio Arts & Acoust, Chicago, IL 60605 USA.
[Zhang, Peter Xinya; Hartmann, William M.] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
RP Zhang, PX (reprint author), Columbia Coll Chicago, Dept Audio Arts & Acoust, Chicago, IL 60605 USA.
EM pzhang@colum.edu; hartmann@pa.msu.edu
FU NIDCD [DC00181]
FX Dr. Brad Rakerd provided important technical help in early stages of
this work and suggested Experiment 8. We are also grateful to Dr. John
Middlebrooks, and Dr. Ewan Macpherson for helpful discussions. This work
was supported by the NIDCD Grant DC00181.
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NR 49
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 30
EP 46
DI 10.1016/j.heares.2009.11.001
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400004
PM 19900525
ER
PT J
AU Ohlemiller, KK
Rosen, AD
Gagnon, PM
AF Ohlemiller, Kevin K.
Rosen, Allyson D.
Gagnon, Patricia M.
TI A major effect QTL on chromosome 18 for noise injury to the mouse
cochlear lateral wall
SO HEARING RESEARCH
LA English
DT Article
DE Stria vascularis; Spiral ligament; Spiral limbus; Endocochlear
potential; Fibrocytes; C57BL/6; CBA/J; Nirep
ID INDUCED HEARING-LOSS; MITOCHONDRIAL DYSFUNCTION; ACOUSTIC TRAUMA; MICE;
AGE; SUSCEPTIBILITY; STRAINS; MECHANISMS; GENOTYPE; MODELS
AB We recently demonstrated a striking difference among inbred mouse strains in the effects of a single noise exposure, whereby CBA/J and CBA/CaJ (CBA) mice show moderate reversible reduction in the endocochlear potential (EP) while C57BL/6J (B6) mice do not (Ohlemiller, K.K., Gagnon, P.M., 2007. Genetic dependence of cochlear cells and structures injured by noise. Hear. Res. 224, 34-50). Acute EP reduction in CBA was reliably associated with characteristic pathology of the spiral ligament and stria vascularis, both immediately after noise and 8 weeks later. Analysis of B6 x CBA F1 hybrid mice indicated that EP reduction and its anatomic correlates are co-inherited in an autosomal dominant manner. Further analysis of N2 mice resulting from the backcross of F1 hybrids to B6 mice led us to suggest that the EP reduction phenotype principally reflects the influence of a small number of quantitative trait loci (QTLs). Here we report the results of QTL mapping of the EP reduction phenotype in CBA/J using 106 N2 mice from a (CBA x B6) x B6 backcross. Correlation of acute post-noise EP with 135 markers distributed throughout the genome revealed a single major effect QTL on chromosome 18 (12.5 cM, LOD 3.57) (Nirep, for noise-induced reduction in EP QTL, and two marginally significant QTLs on chromosomes 5 and 16 (LOD 1.43 and 1.73, respectively). Our results underscore that fact that different cochlear structures may possess different susceptibilities to noise through the influence of non-overlapping genes. While Nirep and similar-acting QTLs do not appear to influence the extent of permanent hearing loss from a single noise exposure, they could reduce the homeostatic 'reserve' of the lateral wall in protracted or continual exposures, and thereby influence long term threshold stability. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ohlemiller, Kevin K.; Gagnon, Patricia M.] Washington Univ, Fay & Carl Simons Ctr Biol Hearing & Deafness, Dept Otolaryngol, Sch Med, St Louis, MO 63110 USA.
[Ohlemiller, Kevin K.; Rosen, Allyson D.] Washington Univ, Sch Med, Program Audiol & Commun Sci, St Louis, MO 63110 USA.
RP Ohlemiller, KK (reprint author), Washington Univ, Fay & Carl Simons Ctr Biol Hearing & Deafness, Dept Otolaryngol, Sch Med, 660 S Euclid, St Louis, MO 63110 USA.
EM kohlemiller@wustl.edu
FU NIH [R01 DC03454, DC08321, P30 DC04665]; Washington University
Department of Otolaryngology
FX Thanks to Dr. K.R. Johnson for comments on the manuscript, Supported by
NIH R01 DC03454, DC08321 (K.K.O.), P30 DC04665 (R. Chole), and
Washington University Department of Otolaryngology.
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NR 36
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 47
EP 53
DI 10.1016/j.heares.2009.11.006
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400005
PM 19913606
ER
PT J
AU Baskent, D
Eiler, CL
Edwards, B
AF Baskent, Deniz
Eiler, Cheryl L.
Edwards, Brent
TI Phonemic restoration by hearing-impaired listeners with mild to moderate
sensorineural hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE Phonemic restoration; Auditory scene analysis; Top-down processing;
Bottom-up processing; Hearing impairment; Aging
ID SPEECH-RECEPTION THRESHOLD; AUDITORY SCENE ANALYSIS; PERCEPTUAL
RESTORATION; STREAM SEGREGATION; BOTTOM-UP; SENTENCE INTELLIGIBILITY;
FREQUENCY-SELECTIVITY; CONTINUITY ILLUSION; ELDERLY LISTENERS;
INTERVENING NOISE
AB The auditory system is capable of perceptually restoring inaudible portions of speech. This restoration may be compromised as a result of hearing impairment, particularly if it is combined with advanced age, because of degradations in the bottom-up and top-down processes. To test this hypothesis, phonemic restoration was quantitatively measured with hearing-impaired listeners of varying ages and degrees of hearing impairment, as well as with a normal hearing control group. The results showed that the restoration benefit was negatively correlated with both hearing impairment and age, supporting the original hypothesis. Group data showed that listeners with mild hearing loss were able to perceptually restore the missing speech segments as well as listeners with normal hearing. By contrast, the moderately-impaired listeners showed no evidence of perceptual restoration. Further analysis using the articulation index showed that listeners with mild hearing loss were able to increase phonemic restoration with audibility. Moderately-impaired listeners, on the other hand, were unable to do so, even when the articulation index was high. The overall findings suggest that, in addition to insufficient audibility, degradations in the bottom-up and/or top-down mechanisms as a result of hearing loss may limit or entirely prevent phonemic restoration. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Baskent, Deniz; Eiler, Cheryl L.; Edwards, Brent] Starkey Hearing Res Ctr, Berkeley, CA 94704 USA.
RP Baskent, D (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, POB 30001, NL-9700 RB Groningen, Netherlands.
EM d.baskent@med.umcg.nl; cheryl_eiler@starkey.com;
brent_edwards@starkey.com
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NR 101
TC 12
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 54
EP 62
DI 10.1016/j.heares.2009.11.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400006
PM 19922784
ER
PT J
AU Kals, M
Schatzer, R
Krenmayr, A
Vermeire, K
Visser, D
Bader, P
Neustetter, C
Zangerl, M
Zierhofer, C
AF Kals, Mathias
Schatzer, Reinhold
Krenmayr, Andreas
Vermeire, Katrien
Visser, Daniel
Bader, Paul
Neustetter, Christian
Zangerl, Matthias
Zierhofer, Clemens
TI Results with a cochlear implant channel-picking strategy based on
"Selected Groups"
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Selected groups; Speech coding; Electrical
stimulation; Channel interaction
ID SPEECH RECOGNITION; PROCESSING STRATEGIES; PHONEME RECOGNITION;
AUDITORY-NERVE; DYNAMIC-RANGE; STIMULATION; NUMBER
AB A novel channel-picking strategy for cochlear implants (CIs) which considers the spatial distribution and the spectral relevance of the channels selected for stimulation is described. In the proposed strategy, the available channels are subdivided into groups, designated as "Selected Groups" (SG), and within each group, a specified number of active channels with the largest amplitudes are selected for stimulation. The hypothesis is that most of the spectral information that can be perceived by CI listeners is conveyed by taking the highest filter band outputs within a stimulation area represented by a group of neighboring channels. Two experiments were conducted in subjects with MED-EL implant systems, measuring recognition of sentences in speech-shaped noise. In experiment 1, the SG group size was varied from two to four while selecting one active channel per group and keeping the pulse phase durations constant. Results showed no significant difference in sentence recognition between continuous interleaved sampling and SG configurations up to a group size of three. In experiment 2, phase durations were doubled, using groups of two channels with one active channel each. This resulted in a reduction of pulse amplitudes by about 40%. Intelligibility of sentences in noise was unaffected, making a substantial reduction of implant supply voltages feasible. In all experiments, the stimulation frame rate was kept constant in order to avoid rate-change effects. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Kals, Mathias; Schatzer, Reinhold; Krenmayr, Andreas; Vermeire, Katrien; Visser, Daniel; Bader, Paul; Neustetter, Christian; Zangerl, Matthias; Zierhofer, Clemens] Univ Innsbruck, Inst Ion Phys & Appl Phys, C Doppler Lab Act Implantable Syst, A-6020 Innsbruck, Austria.
RP Kals, M (reprint author), Univ Innsbruck, Inst Ion Phys & Appl Phys, C Doppler Lab Act Implantable Syst, Tech Str 25, A-6020 Innsbruck, Austria.
EM mathias.kals@uibk.ac.at
FU Austrian C. Doppler Research Association (CDG)
FX We thank our subjects for participating in this study. This work was
supported by the Austrian C. Doppler Research Association (CDG).
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NR 26
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 63
EP 69
DI 10.1016/j.heares.2009.11.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400007
PM 19944138
ER
PT J
AU Larsen, E
Liberman, MC
AF Larsen, Erik
Liberman, M. Charles
TI Contralateral cochlear effects of ipsilateral damage: No evidence for
interaural coupling
SO HEARING RESEARCH
LA English
DT Article
DE Hearing loss; Feedback; Acoustic injury
ID CROSSED OLIVOCOCHLEAR BUNDLE; HEARING-LOSS; LOUD SOUND; EFFERENT
INNERVATION; NEURONS; NOISE; EAR; REFLEX; STIMULATION; SENSITIVITY
AB Lesion studies of the olivocochlear efferents have suggested that feedback via this neuronal pathway normally maintains an appropriate binaural balance in excitability of the two cochlear nerves (Darrow et al., 2006). If true, a decrease in cochlear nerve output from one ear, due to conductive or sensorineural hearing loss, should change cochlear nerve response in the opposite ear via modulation in olivocochlear feedback. To investigate this putative efferent-mediated interaural coupling, we measured cochlear responses repeatedly from both ears in groups of mice for several weeks before, and for up to 5 weeks after, a unilateral manipulation causing either conductive or sensorineural hearing loss. Response measures included amplitude vs. level functions for distortion product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABRs), evoked at 7 log-spaced frequencies. Ipsilateral manipulations included either tympanic membrane removal or an acoustic overstimulation designed to produce a reversible or irreversible threshold shift over a restricted frequency range. None of these ipsilateral manipulations produced systematic changes in contralateral cochlear responses, either at threshold or suprathreshold levels, either in ABRs or DPOAEs. Thus, we find no evidence for compensatory contralateral changes following ipsilateral hearing loss. We did, however, find evidence for age-related increases in DPOAE amplitudes as animals mature from 6 to 12 weeks and evidence for a slow apical spread of noise-induced threshold shifts, which continues for several days post-exposure. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Larsen, Erik; Liberman, M. Charles] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Larsen, Erik; Liberman, M. Charles] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02139 USA.
[Liberman, M. Charles] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02215 USA.
RP Liberman, MC (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Labs, 243 Charles St, Boston, MA 02114 USA.
EM charles_liberman@meei.harvard.edu
FU NIH [R01 DC00188, P30 DC005209]
FX This work was supported by NIH Grants R01 DC00188 and P30 DC005209. E.
Larsen was partly supported by NIH Training Grant T32 DC00038. This
paper is based on a thesis submitted in partial fulfillment of the
requirements for the degree of Doctor of Philosophy in the Speech and
Hearing Bioscience and Technology Program of the Harvard-MIT Division of
Health Sciences and Technology in September, 2008.
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NR 30
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 70
EP 80
DI 10.1016/j.heares.2009.11.011
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400008
PM 19944141
ER
PT J
AU Wong, ACY
Guo, CX
Gupta, R
Housley, GD
Thorne, PR
Vlajkovic, SM
AF Wong, Ann Chi Yan
Guo, Cindy X.
Gupta, Rita
Housley, Gary D.
Thorne, Peter R.
Vlajkovic, Srdjan M.
TI Post exposure administration of A(1) adenosine receptor agonists
attenuates noise-induced hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE Adenosine receptors; Cochlea; Hearing; Noise; Otoprotection
ID RAT COCHLEA; CHINCHILLA COCHLEA; BLOOD-FLOW; INNER-EAR; EXPRESSION;
PROTECTION; TRIPHOSPHATE; OTOTOXICITY; MECHANISMS; ISCHEMIA
AB Adenosine is a constitutive cell metabolite with a putative role in protection and regeneration in many tissues. This study was undertaken to determine if adenosine signalling pathways are involved in protection against noise injury. A, adenosine receptor expression levels were altered in the cochlea exposed to loud sound, suggesting their involvement in the development of noise injury. Adenosine and selective adenosine receptor agonists (CCPA, CGS-21680 and CI-IB-MECA) were applied to the round window membrane of the cochlea 6 h after noise exposure. Auditory brainstem responses measured 48 h after drug administration demonstrated partial recovery of hearing thresholds (up to 20 dB) in the cochleae treated with adenosine (non-selective adenosine receptor agonist) or CCPA (selective A(1) adenosine receptor agonist). In contrast, the selective A(2A) adenosine receptor agonist CGS-21680 and A(3) adenosine receptor agonist CI-IB-MECA did not protect the cochlea from hearing loss. Sound-evoked cochlear potentials in control rats exposed to ambient noise were minimally altered by local administration of the adenosine receptor agonists used in the noise study. Free radical generation in the cochlea exposed to noise was reduced by administration of adenosine and CCPA. This study pinpoints A, adenosine receptors as attractive targets for pharmacological interventions to reduce noise-induced cochlear injury after exposure. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Wong, Ann Chi Yan; Guo, Cindy X.; Gupta, Rita; Housley, Gary D.; Thorne, Peter R.; Vlajkovic, Srdjan M.] Univ Auckland, Dept Physiol, Fac Med & Hlth Sci, Auckland, New Zealand.
[Thorne, Peter R.] Univ Auckland, Sect Audiol, Sch Populat Hlth, Auckland 1, New Zealand.
[Housley, Gary D.] Univ New S Wales, Sch Med Sci, Dept Physiol, Sydney, NSW, Australia.
RP Vlajkovic, SM (reprint author), Univ Auckland, Dept Physiol, Fac Med & Hlth Sci, Private Bag 92019, Auckland, New Zealand.
EM ann.wong@auckland.ac.nz; c.guo@auckland.ac.nz; RitaG@adhb.govt.nz;
g.housley@unsw.edu.au; pr.thorne@auckland.ac.nz;
s.vlajkovic@auckland.ac.nz
RI Wong, Ann CY/C-3660-2012
FU Royal National Institute for Deaf People (RNID, UK); Deafness Research
Foundation (NZ); Auckland Medical Research Foundation
FX This study was supported by the Royal National Institute for Deaf People
(RNID, UK), Deafness Research Foundation (NZ) and Auckland Medical
Research Foundation.
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NR 32
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 81
EP 88
DI 10.1016/j.heares.2009.12.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400009
PM 19995597
ER
PT J
AU Ardoint, M
Lorenzi, C
AF Ardoint, Marine
Lorenzi, Christian
TI Effects of lowpass and highpass filtering on the intelligibility of
speech based on temporal fine structure or envelope cues
SO HEARING RESEARCH
LA English
DT Article
DE Filtering; Intelligibility; Speech; Temporal envelope; Temporal fine
structure
ID AUDITORY-NERVE FIBERS; FUNDAMENTAL-FREQUENCY; PERCEPTION; RECOGNITION;
AMPLITUDE; TONES; RESPONSES; HEARING; SOUNDS
AB This study aimed to assess whether or not temporal envelope (E) and fine structure (TFS) cues in speech convey distinct phonetic information. Syllables uttered by a male and female speaker were (i) processed to retain either E or TFS within 16 frequency bands, (ii) lowpass or highpass filtered at different cut-off frequencies, and (iii) presented for identification to seven listeners. Psychometric functions were fitted using a sigmoid function, and used to determine crossover frequencies (cut-off frequencies at which lowpass and highpass filtering yielded equivalent performance), and gradients at each point of the psychometric functions (change in performance with respect to cut-off frequency). Crossover frequencies and gradients were not significantly different across speakers. Crossover frequencies were not significantly different between E and TFS speech (similar to 1.5 kHz). Gradients were significantly different between E and TFS speech in various filtering conditions. When stimuli were highpass filtered above 2.5 kHz, performance was significantly above chance level and gradients were significantly different from 0 for E speech only. These findings suggest that E and TFS convey important but distinct phonetic cues between 1 and 2 kHz. Unlike TFS, E conveys information up to 6 kHz, consistent with the characteristics of neural phase locking to E and TFS. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ardoint, Marine; Lorenzi, Christian] Univ Paris 05, DEC, Ecole Normale Super, CNRS,Lab Psychol Percept, F-75005 Paris, France.
RP Ardoint, M (reprint author), Univ Paris 05, DEC, Ecole Normale Super, CNRS,Lab Psychol Percept, 29 Rue Ulm, F-75005 Paris, France.
EM marine.ardoint@ens.fr
RI Lorenzi, Christian/F-5310-2012
FU MENRT; ANR-Presbycusis; DUALPRO [FP7-SME-2007-1]
FX This research was supported by a MENRT grant to the first author, and an
ANR-Presbycusis and DUALPRO (FP7-SME-2007-1, EQ grant to the second
author.
CR ARDOINT M, EFFECTS COMBIN UNPUB
ARDOINT M, PERCEPTION TEM UNPUB
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NR 34
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 89
EP 95
DI 10.1016/j.heares.2009.12.002
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400010
PM 19963053
ER
PT J
AU Slee, SJ
Young, ED
AF Slee, Sean J.
Young, Eric D.
TI Sound localization cues in the marmoset monkey
SO HEARING RESEARCH
LA English
DT Article
DE (3-6) ITD; ILD; Spectral notch; Sound localization; HRTF; Marmoset
behavior
ID EAR TRANSFER-FUNCTIONS; EXTERNAL-EAR; PRESSURE TRANSFORMATION; NEURAL
REPRESENTATIONS; AUDITORY-CORTEX; SPECTRAL CUES; INFERIOR COLLICULUS;
TIME DIFFERENCES; ACOUSTICAL CUES; AWAKE PRIMATES
AB The most important acoustic cues available to the brain for sound localization are produced by the interaction of sound with the animal's head and external ears. As a first step in understanding the relation between these cues and their neural representation in a vocal new-world primate, we measured head-related transfer functions (HRTFs) across frequency for a wide range of sound locations in three anesthetized marmoset monkeys. The HRTF magnitude spectrum has a broad resonance peak at 6-12 kHz that coincides with the frequency range of the major can types of this species. A prominent first spectral notch (FN) in the HRTF magnitude above this resonance was observed at most source locations. The center frequency of the FN increased monotonically from similar to 12 to 26 kHz with increases in elevation in the lateral field. In the frontal field FN frequency changed in a less orderly fashion with source position. From the HRTFs we derived interaural time (ITDs) and level differences (ILDs). ITDs and ILDs (below 12 kHz) varied as a function of azimuth between +/- 250 mu s and +/- 20 dB, respectively. A reflexive orienting behavioral paradigm was used to confirm that marmosets can orient to sound sources. Published by Elsevier B.V.
C1 [Slee, Sean J.; Young, Eric D.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA.
RP Slee, SJ (reprint author), Johns Hopkins Univ, Dept Biomed Engn, 505 Traylor Res Bldg,720 Rutland Ave, Baltimore, MD 21205 USA.
EM sslee1@jhmi.edu
FU NIDCD [DC00115, DC00023]
FX We thank Dr. Bradford May for assistance with surgical design and the
behavioral experiments, Ron Atkinson, Jay Burns, Phyllis Taylor, and
Qian Gao for technical assistance, and jenny Estes and Judy Cook for
assistance with animal care. This work was supported by grants DC00115
and DC00023 from NIDCD.
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NR 51
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 96
EP 108
DI 10.1016/j.heares.2009.12.001
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400011
PM 19963054
ER
PT J
AU Supin, AY
Popov, VV
Milekhina, ON
Tarakanov, MB
AF Supin, Alexander Ya.
Popov, Vladimir V.
Milekhina, Olga N.
Tarakanov, Mikhail B.
TI Masking of rippled-spectrum-pattern resolution in diotic and dichotic
presentations
SO HEARING RESEARCH
LA English
DT Article
DE Spectrum-pattern resolution; Rippled spectra; Masking; Dichotic release
ID SIMULATED ANECHOIC ENVIRONMENT; HEARING-IMPAIRED LISTENERS; BROAD-BAND
SIGNALS; SPEECH-INTELLIGIBILITY; INFORMATIONAL MASKING; SPATIAL
SEPARATION; ENERGETIC MASKING; SIMULTANEOUS TALKERS; DENSITY RESOLUTION;
LEVEL DIFFERENCES
AB Using rippled noise probes, spectrum-pattern resolution was measured with and without a narrow-band noise masker. Diotic presentation of both the probe and masker (S(0)N(0) mode) resulted in decreased spectrum resolution as compared to the control (no masker) conditions. The effects of the low- and on-frequency maskers differed quantitatively, however in both cases the ability to discriminate the probe spectrum pattern was suppressed completely when the masker/probe level ratio exceeded 10 dB (on-frequency masker) or 10-25 dB, depending on the probe level (low-frequency masker). The effect of the high-frequency masker was negligible. Slight but noticeable releasing of the spectrum-pattern resolution was found when the probe was presented to both ears in-phase and the masker counter-phase (S(0)N(pi) mode). In conditions of the probe delivered to one ear and the masker to the other ear (S(L)N(R) mode), the effect on the spectrum-pattern resolution was slight or negligible within a wide range of the noise/probe ratio. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Supin, Alexander Ya.; Popov, Vladimir V.; Milekhina, Olga N.; Tarakanov, Mikhail B.] Russian Acad Sci, Inst Ecol & Evolut, Moscow 119071, Russia.
RP Supin, AY (reprint author), Russian Acad Sci, Inst Ecol & Evolut, 33 Leninsky Prospect, Moscow 119071, Russia.
EM alex_supin@mail.ru
FU Russian Foundation for Basic Research [08-04-00460]; Russian Ministry of
Education and Sciences [NSh-157.2008.4]
FX The study was supported by the Russian Foundation for Basic Research,
Grant 08-04-00460, and the Russian Ministry of Education and Sciences,
Grant NSh-157.2008.4. Valuable comments of two anonymous reviewers
helped very much to improve the manuscript.
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NR 57
TC 0
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2010
VL 260
IS 1-2
BP 109
EP 116
DI 10.1016/j.heares.2009.12.018
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 559RR
UT WOS:000274844400012
PM 20005938
ER
PT J
AU Rhode, WS
Roth, GL
Recio-Spinoso, A
AF Rhode, William S.
Roth, G. Linn
Recio-Spinoso, Alberto
TI Response properties of cochlear nucleus neurons in monkeys
SO HEARING RESEARCH
LA English
DT Article
DE Primates; Response properties; Cochlear nucleus; Auditory system
ID AUDITORY-NERVE FIBERS; SINGLE-UNIT-ACTIVITY; DIFFERING SPONTANEOUS RATE;
LOW-FREQUENCY TONES; SQUIRREL-MONKEY; CENTRAL PROJECTIONS;
HORSERADISH-PEROXIDASE; NEURAL SYNCHRONIZATION; AMPLITUDE-MODULATION;
REGULARITY ANALYSIS
AB Much of what is known about how the cochlear nuclei participate in mammalian hearing comes from studies of non-primate mammalian species. To determine to what extent the cochlear nuclei of primates resemble those of other mammalian orders, we have recorded responses to sound in three primate species: marmosets, cynomolgus macaques, and squirrel monkeys. These recordings show that the same types of temporal firing patterns are found in primates that have been described in other mammals. Responses to tones of neurons in the ventral cochlear nucleus have similar tuning, latencies, post-stimulus time and interspike interval histograms as those recorded in non-primate cochlear nucleus neurons. In the dorsal cochlear nucleus, too, responses were similar. From these results it is evident that insights gained from non-primate studies can be applied to the peripheral auditory system of primates. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Rhode, William S.; Roth, G. Linn; Recio-Spinoso, Alberto] Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
RP Rhode, WS (reprint author), Univ Wisconsin, Dept Physiol, 1300 Univ Ave, Madison, WI 53706 USA.
EM rhode@physiology.wisc.edu; rothlinn@sbcglobal.net; a.recio@lumc.nl
RI Recio-Spinoso, Alberto/F-7744-2013
FU NIDCD [17590]
FX We are greatly indebted to our colleagues, Donata Oertel, Don Sinex, and
Phil Smith, for their review of this manuscript. This study was funded
by NIDCD Grant 17590.
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NR 94
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 1
EP 15
DI 10.1016/j.heares.2009.06.004
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100001
PM 19531377
ER
PT J
AU Ding, DL
Jiang, HY
Salvi, RJ
AF Ding, Dalian
Jiang, Haiyan
Salvi, Richard J.
TI Mechanisms of rapid sensory hair-cell death following co-administration
of gentamicin and ethacrynic acid
SO HEARING RESEARCH
LA English
DT Article
DE Hair cells; Gentamicin; Ethacrynic acid; Apoptosis; Cytochrome c;
Caspase-9; Caspase-8; Caspase-3
ID AMINOGLYCOSIDE ANTIBIOTICS; STRIA VASCULARIS; HEARING-LOSS; IN-VIVO;
PROTECTS COCHLEAR; AUDITORY-NERVE; KANAMYCIN; APOPTOSIS; OTOTOXICITY;
INHIBITION
AB Concurrent administration of a high dose of gentamicin (GM; 125 mg/kg IM) and ethacrynic acid (EA; 40 mg/kg IV) results in rapid destruction of virtually all cochlear hair cells; however, the cell death signaling pathways underlying this rapid form of hair-cell degeneration are unclear. To elucidate the mechanisms underlying GM/EA-mediated cell death, several key cell death markers were assessed in the chinchilla cochlea during the early stages of degeneration. In the middle and basal turns of the cochlea, massive hair-cell loss including destruction of the stereocilia and cuticular plate occurred 12 h after GM/EA treatment. Condensation and fragmentation of outer hair-cell nuclei, morphological features of apoptosis, were first observed 5-6 h post-treatment in the basal turn of the cochlea. Metabolic function, reflected by succinate dehydrogenase histochemistry and mitochondrial staining, decreased significantly in the basal turn 4 h following GM/EA treatment; these early changes were accompanied by the release of cytochrome c from the mitochondria into the cytosol and intense expression of initiator caspase-9 and effector caspase-3. GM/EA failed to induce expression of extrinsic initiator caspase-8. These results suggest that the rapid loss of hair cells following GM/EA treatment involves cell death pathways mediated by mitochondrial dysfunction leading to the release of cytochrome c, activation of initiator caspase-9 and effector caspase-3. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ding, Dalian; Jiang, Haiyan; Salvi, Richard J.] SUNY Buffalo, Dept Communicat Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Salvi, RJ (reprint author), SUNY Buffalo, Dept Communicat Disorders & Sci, Ctr Hearing & Deafness, 137 Cary Hall, Buffalo, NY 14214 USA.
EM salvi@buffalo.edu
FU NIH [501DC006630-05]
FX This research was supported in part by NIH Grant 501DC006630-05.
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NR 70
TC 24
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 16
EP 23
DI 10.1016/j.heares.2009.08.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100002
PM 19715747
ER
PT J
AU Eastwood, H
Pinder, D
James, D
Chang, A
Galloway, S
Richardson, R
O'Leary, S
AF Eastwood, Hayden
Pinder, Darren
James, David
Chang, Andrew
Galloway, Stuart
Richardson, Rachael
O'Leary, Stephen
TI Permanent and transient effects of locally delivered n-acetyl cysteine
in a guinea pig model of cochlear implantation
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implantation; Round window membrane; n-Acetyl cysteine;
Residual hearing
ID INDUCED HEARING-LOSS; ELECTRODE INSERTION TRAUMA; NITRIC-OXIDE-SYNTHASE;
IMPULSE NOISE TRAUMA; CISPLATIN OTOTOXICITY; ACOUSTIC STIMULATION;
RESIDUAL HEARING; AUDITORY-SYSTEM; D-METHIONINE; ACETYLCYSTEINE
AB Protection of residual hearing after cochlear implant surgery can improve the speech and music perception of cochlear implant recipients, particularly in the presence of background noise. Surgical trauma and chronic inflammation are thought to be responsible for a significant proportion of residual hearing loss after surgery. Local delivery of the anti-oxidant precursor n-acetyl cysteine (NAC) to the cochlea via round window 30 min prior to surgery, increased the level of residual hearing at 24-32 kHz 4 weeks post surgery compared to controls. The hearing protection was found in the basal turn near the site of implantation. Coincidentally, the basal turn was also the location that sustained the greatest hearing loss. As well as protecting residual hearing, NAC-treated animals demonstrated a reduction in the chronic inflammatory changes associated with implantation. While these findings indicate that anti-oxidant therapy can be used to reduce the hearing loss associated with surgical trauma, the local delivery of NAC was associated with a transient increase in hearing thresholds, and osseoneogenesis was seen in a greater number of NAC-treated animals. These side-effects would limit its clinical use through local cochlear administration. However, it is not known yet whether these effects would also be produced by other anti-oxidants, or ameliorated by using a different route of administration. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Eastwood, Hayden; Pinder, Darren; James, David; Chang, Andrew; O'Leary, Stephen] Univ Melbourne, Melbourne, Vic 3002, Australia.
[Galloway, Stuart] St Vincents Pathol, Melbourne, Vic, Australia.
RP Eastwood, H (reprint author), Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
EM haydente@unimelb.edu.au
FU Garnett Passe and Rodney Williams Memorial Foundation; National Health
and Medical Research Council Australia; NIDCD [HHS-N-263-2007-00053-C];
National Institute on Deafness and Other Communication Disorders,
National Institutes of Health [DC 01368]
FX Project grants from the Garnett Passe and Rodney Williams Memorial
Foundation and the National Health and Medical Research Council
Australia.Helen Feng for manufacturing electrode arrays.Maria Clark and
Prudence Nielsen for preparing histological materials.Dr. James Fallon
for providing the ABR analysis program (NIDCD Contract
HHS-N-263-2007-00053-C; PI: RK Shepherd).Dr. Alec Salt, Washington
University Cochlear Fluids Simulator: Version 1.6 available from
http://oto.wustl.edu/cochlea/modet.htm (This program was developed and
is made available by Grant funding (DC 01368) from the National
Institute on Deafness and Other Communication Disorders, National
Institutes of Health.).Dimitra Stathopoulos for editing the manuscript.
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NR 53
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 24
EP 30
DI 10.1016/j.heares.2009.08.010
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100003
PM 19732818
ER
PT J
AU Hederstierna, C
Hultcrantz, M
Collins, A
Rosenhall, U
AF Hederstierna, C.
Hultcrantz, M.
Collins, A.
Rosenhall, U.
TI The menopause triggers hearing decline in healthy women
SO HEARING RESEARCH
LA English
DT Article
DE Female; Audiometry; Estrogen; Left; Right; Asymmetry
ID OTOACOUSTIC EMISSIONS; POSTMENOPAUSAL WOMEN; ESTROGEN-RECEPTORS;
RANDOM-POPULATION; EAR ASYMMETRIES; SEX-DIFFERENCES; INNER-EAR; CBA
MICE; AGE; SENSITIVITY
AB Background: Epidemiological studies have shown that women have better high-frequency thresholds than men in virtually all age groups, and that age-related hearing decline starts after 30 in men but not until after the age of 50 in women. This coincides with the menopausal transition in most women, thus leading us to hypothesize that the menopause triggers auditory deterioration, possibly due to reduced levels of endogenous estrogens, which are known to have protective effects on the auditory system. Methods: 104 women with a mean age 51.2 at baseline, were tested with pure tone audiometry twice with an average interval of 7.5 years. The age at the final menstrual period (FMP) was reported by all women. Hearing decline at individual frequencies was calculated. Results: Women with a FMP 0-4 years ago, had a rate of high frequency hearing decline of 0.9-1.5 dB/year in the left ear, those with 5-7 years since the FMP had a corresponding rate of 1.1-1.5 dB/year in the right ear, and 8-13 years after the FMP the decline was more subtle, 0.7-1.1 dB/year in both ears. Conclusion: The menopause appears to act as a trigger of a relatively rapid age-related hearing decline in healthy women, starting in the left ear. (C) 2009 Published by Elsevier B.V.
C1 [Hederstierna, C.; Hultcrantz, M.; Rosenhall, U.] Karolinska Inst, Dept Clin Neurosci, Div Otorhinolaryngol & Hearing, Stockholm, Sweden.
[Collins, A.] Karolinska Inst, Dept Clin Neurosci, Div Psychol, Stockholm, Sweden.
RP Hederstierna, C (reprint author), Karolinska Univ Hosp, Dept Hearing & Balance, S-17176 Stockholm, Sweden.
EM christina.hederstierna@karolinska.se
FU The Foundation Tysta Skolan; The Foundation for Audiological Research
(Stingerfonden); The Swedish Association of Hard of Hearing People (HRF)
FX This study was funded by grants from The Foundation Tysta Skolan, The
Foundation for Audiological Research (Stingerfonden), and The Swedish
Association of Hard of Hearing People (HRF).
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NR 29
TC 11
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 31
EP 35
DI 10.1016/j.heares.2009.09.009
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100004
PM 19781610
ER
PT J
AU Getzmann, S
Lewald, J
AF Getzmann, Stephan
Lewald, Joerg
TI Effects of natural versus artificial spatial cues on
electrophysiological correlates of auditory motion
SO HEARING RESEARCH
LA English
DT Article
DE Spatial hearing; Sound localization; Auditory motion cues; Binaural
cues; EEG
ID HUMAN CEREBRAL-CORTEX; SOUND LOCALIZATION; HUMAN BRAIN;
EVOKED-POTENTIALS; INTERAURAL TIME; PERCEPTION; MOVEMENT; ACTIVATION;
DYNAMICS; HUMANS
AB The effect of the type of the auditory motion stimulus on neural correlates of motion processing were investigated using high-density electroencephalography. Sound motion was implemented by (a) gradual shifts in interaural time or (b) level difference; (c) motion of virtual 3D sound sources; or (d) successive activation of 45 loudspeakers along the horizontal plane. In a subset of trials, listeners (N = 20) performed a two-alternative forced-choice motion discrimination task. Each trial began with a stationary phase of the acoustic stimulus in a central position, immediately followed by a motion of the stimulus. The motion onset elicited a specific cortical response that was dominated by large negative and positive deflections, the so-called change-N1 and change-P2. The temporal dynamics of these components depended on the auditory motion cues presented: Free-field motion and virtual 3D motion were associated with earlier cortical responses and with shorter reaction times than shifts in interaural time or level. Also, free-field motion elicited much stronger onset responses than simulated motion. These findings suggest that natural-like stimulation using stimuli presented in the free sound field allows more reliable conclusions on neural processing of sound motion, whereas artificial motion stimuli, in particular gradual shifts in interaural time or level, seem to be less suited with respect to this aim. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Getzmann, Stephan] Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany.
Ruhr Univ Bochum, D-44780 Bochum, Germany.
RP Getzmann, S (reprint author), Leibniz Res Ctr Working Environm & Human Factors, Ardeystr 67, D-44139 Dortmund, Germany.
EM stephan.getzmann@rub.de
RI Lewald, Jorg/D-3034-2009
OI Lewald, Jorg/0000-0001-9351-0170
FU Deutsche Forschungsgemeinschaft [Ge1920/2-1, Fa211/24-1]
FX The authors are especially grateful to Ines Mombrei for her help in
running the experiments, and to Michael Falkenstein and two anonymous
reviewers for valuable comments on an earlier draft of the manuscript.
This work was supported by the Deutsche Forschungsgemeinschaft
(Ge1920/2-1; Fa211/24-1).
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NR 55
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 44
EP 54
DI 10.1016/j.heares.2009.09.021
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100005
PM 19800957
ER
PT J
AU Mazurek, B
Haupt, H
Joachim, R
Klapp, BF
Stover, T
Szczepek, AJ
AF Mazurek, Birgit
Haupt, Heidemarie
Joachim, Ricarda
Klapp, Burghard F.
Stoever, Timo
Szczepek, Agnieszka J.
TI Stress induces transient auditory hypersensitivity in rats
SO HEARING RESEARCH
LA English
DT Article
DE Stress; ABR; DPOAE; Corticosterone; Auditory hypersensitivity; Gene
expression
ID OUTER HAIR-CELLS; FACTOR-KAPPA-B; GLUCOCORTICOID-RECEPTOR; RESTRAINT
STRESS; INFERIOR COLLICULUS; ACOUSTIC TRAUMA; GENE-EXPRESSION; NOISE
EXPOSURE; MOTOR PROTEIN; HEARING-LOSS
AB Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction in exposed animals. In addition to the activated hypothalamic-pituitary-adrenal (HPA) axis, exposed animals had pathological reactions in the reproductive organs, bronchia and skin. Here, we examined the effect of above stress model on the auditory system of Wistar rats. We found that 24-h stress decreases the thresholds and increases the amplitudes of auditory brainstem responses and distortion product otoacoustic emissions. Resultant auditory hypersensitivity was transient and most pronounced between 3 and 6 h post-stress, returning to control levels one week later. The concentration of corticosterone and tumor necrosis factor alpha was systemically elevated in stressed animals between 3 and 6 h post-stress, confirming the activation of the HPA axis. In addition, expression of the HPA-axis-associated genes: glucocorticoid receptor (GR) and hypoxia-inducible factor 1 alpha (Hif1a) was modulated in the auditory tissues. In detail, in the inferior colliculus, we found an up-regulation of GR mRNA 3 h post-stress and continuous up-regulation of Hif1a up to 24 h post-stress. In the spiral ganglion, we found no differences in gene expression between stressed and control animals. In the organ of Corti, expression of GR mRNA remained stable, whereas that of Hif1a was significantly down-regulated one week after stress. In addition, the expression of an outer hair cell marker prestin was significantly up-regulated 6 h post-stress. We conclude that 24-h stress induces transient hypersensitivity of the auditory system and modulates gene expression in a tissue-specific manner. Stress-induced auditory hypersensitivity could have evolutionary consequence by giving animals an advantage of hearing better under stress conditions. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Mazurek, Birgit] Charite, Dept Otorhinolaryngol, Tinnitus Ctr, Mol Biol Res Lab, D-10117 Berlin, Germany.
[Joachim, Ricarda; Klapp, Burghard F.] Charite, Dept Internal Med & Psychosomat, D-10117 Berlin, Germany.
[Stoever, Timo] Hannover Med Sch, Dept Otorhinolaryngol, Hannover, Germany.
RP Mazurek, B (reprint author), Charite, Dept Otorhinolaryngol, Tinnitus Ctr, Mol Biol Res Lab, Charitepl 1, D-10117 Berlin, Germany.
EM birgit.mazurek@charite.de
FU Charite - Universitatsmedizin Berlin [2008-750, 2008-751]; Sonnenfeld
Foundation, Berlin, Germany
FX This work was supported by grants from the Charite - Universitatsmedizin
Berlin (Gr. 2008-750 and 2008-751) and the Sonnenfeld Foundation,
Berlin, Germany. We thank Ms. Julia Fuchs, Ms. Olga Hegend and Ms.
Astrid Machulik for their excellent technical assistance.
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NR 65
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 55
EP 63
DI 10.1016/j.heares.2009.10.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100006
PM 19840840
ER
PT J
AU Stronks, HC
Versnel, H
Prijs, VF
Klis, SFL
AF Stronks, H. Christiaan
Versnel, Huib
Prijs, Vera F.
Klis, Sjaak F. L.
TI Suppression of the acoustically evoked auditory-nerve response by
electrical stimulation in the cochlea of the guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE Electro-acoustical stimulation; Electrocochleography; Compound action
potential; Cochlear implant
ID COMPOUND ACTION-POTENTIALS; BASILAR-MEMBRANE MOTION; SINGLE-FIBER
RESPONSES; ELECTROACOUSTIC STIMULATION; RESIDUAL HEARING;
FORWARD-MASKING; PULSE TRAINS; IMPLANTATION; SPEECH; CAT
AB There is increasing interest in the use of electro-acoustical stimulation in people with a cochlear implant that have residual low-frequency hearing in the implanted ear. This raises the issue of how electrical and acoustical stimulation interact in the cochlea. We have investigated the effect of electrical stimulation on the acoustically evoked compound action potential (CAP) in normal-hearing guinea pigs. CAPs were evoked by tone bursts, and electric stimuli were delivered at the base of the cochlea using extracochlear electrodes. CAPs could be suppressed by electrical stimulation under various conditions. The dependence of CAP suppression on several parameters was investigated, including frequency and level of the acoustic stimulus, current level of the electric stimulus and the interval between electric and acoustic stimulus (EAI). Most pronounced suppression was observed when CAPs were evoked with high-frequency tones of low level. Suppression increased with current level and at high currents low-frequency evoked CAPs could also be suppressed. Suppression was typically absent several milliseconds after the electric stimulus. Suppression mediated by direct neural responses and hair cell mediated (electrophonic) responses is discussed. We conclude that the high-frequency part of the cochlea can be stimulated electrically with little detrimental effects on CAPs evoked by low-frequency tones. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Klis, Sjaak F. L.] Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Hearing Res Labs, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands.
RP Klis, SFL (reprint author), Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Hearing Res Labs, Rudolf Magnus Inst Neurosci, Room G-02-531,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM c.stronks@umcutrecht.nl; h.versnel@umcutrecht.nl; v.prijs@umcutrecht.nl;
s.klis@umcutrecht.nl
FU Heinsius-Houbolt Fund
FX This study was supported by the Heinsius-Houbolt Fund. The authors thank
Ren van de Vosse for technical assistance and data acquisition and
analysis software, and Rik Mansvelt Beck for technical assistance. The
authors thank the reviewers for their critical comments.
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NR 54
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 64
EP 74
DI 10.1016/j.heares.2009.10.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100007
PM 19840841
ER
PT J
AU Bahmer, A
Polak, M
Baumann, U
AF Bahmer, Andreas
Polak, Marek
Baumann, Uwe
TI Recording of electrically evoked auditory brainstem responses after
electrical stimulation with biphasic, triphasic and precision triphasic
pulses
SO HEARING RESEARCH
LA English
DT Article
DE Biphasic; Triphasic; Precision triphasic; E-ABR; Cochlear implant;
Artifact; Stimulation protocol
ID COMPOUND ACTION-POTENTIALS; COCHLEAR IMPLANT USERS; MONOPHASIC
STIMULATION; NERVE; CAT; ABR; SENSITIVITY; MONOPOLAR; HUMANS; FIBERS
AB Biphasic electrical pulses are the standard stimulation pulses in current cochlear implants. In auditory brainstem recordings biphasic pulses generate a significant artifact that disrupts brainstem responses, which are magnitudes smaller. Triphasic pulses may minimize artifacts by restoring the neural membrane to its resting potential faster than biphasic pulses and make auditory brainstem responses detection easier. We compared biphasic pulses with triphasic and precision triphasic pulses to evoke brainstem responses in human subjects. For this purpose, electrically evoked brainstem response audiometry was performed in 10 (11 ears) cochlear implant patients. Artifacts and brainstem responses evoked by bi- and triphasic stimulation were analyzed. Artifact amplitude and decay time were related to pulse pattern shape, but application of averaging and alternation reduced the deterioration of electrically evoked brainsterm responses independent of pulse pattern shape. Contrary to our expectations, biphasic pulses showed a higher detectability in comparison to triphasic pulse stimulation at the same stimulation amplitude. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bahmer, Andreas; Baumann, Uwe] Univ Frankfurt Main, Clin Otolaryngol, D-60590 Frankfurt, Germany.
[Polak, Marek] MED EL, A-6020 Innsbruck, Austria.
RP Bahmer, A (reprint author), Univ Frankfurt Main, Clin Otolaryngol, D-60590 Frankfurt, Germany.
EM andreas.bahmer@kgu.de; marek.polak@medel.com; uwe.baumann@kgu.de
FU Deutsche Forschungsgemeinschaft [BA 2085/3-1]
FX The authors would like to thank Otto Peter from the University of
Innsbruck for providing the interface (RIB2) for the MED-EL cochlear
implants. We also would like to thank two anonymous reviewers for their
valuable advice and Dr. Jane M. Opie for grammar review. The recordings
were performed under the authorization of the Ethic committee of the
University of Frankfurt. The work was supported by the grant from the
Deutsche Forschungsgemeinschaft (BA 2085/3-1).
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NR 23
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 75
EP 85
DI 10.1016/j.heares.2009.10.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100008
PM 19850116
ER
PT J
AU Kumar, G
Chokshi, M
Richter, CP
AF Kumar, Gagan
Chokshi, Moulin
Richter, Claus-Peter
TI Electrical impedance measurements of cochlear structures using the
four-electrode reflection-coefficient technique
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Hemicochlea; Electrical impedance; Four-electrode
reflection-coefficient method
ID GUINEA-PIG COCHLEA; INNER-EAR; RESISTANCE CHANGES; HEMICOCHLEA
AB In individuals with severe-to-profound hearing loss, cochlear implants (CIs) bypass normal inner ear function by applying electrical current directly into the cochlea, thereby stimulating surviving auditory nerve fibers. Although cochlear implants are able to restore some auditory sensation, they are far from providing normal hearing. It has been estimated that up to 75% of the current injected via a Cl is shunted along scala tympani and is not available to stimulate auditory neurons. The path of the injected current and the consequent population of stimulated spiral ganglion cells are dependent upon the positions of the electrode contacts within the cochlea and the impedances of cochlear structures. However, characterization of the current path remains one of the most critical, yet least understood, aspects of cochlear implantation. In particular, the impedances of cochlear structures, including the modiolus, are either unknown or based upon estimates derived from circuit models. Impedance values for many cochlear structures have never been measured. By combining the hemicochlea preparation, a cochlea cut in half along its mid-modiolar plane, and the four-electrode reflection-coefficient technique, impedances can be measured for cochlear tissues in a cochlear cross section including the modiolus. Advantages and disadvantages of the method are discussed in detail and electrical impedance measurements obtained in the gerbil hemicochlea are presented. The resistivity values for the cochlear wall in Omega cm are, 528 (range: 432-708) for scala media 3rd turn, 502 (range: 421-616) for scala tympani 3rd turn and scala vestibuli 2nd turn, 627 (range: 531-759) for scala media 2nd turn, 434 (range: 353-555) for scala tympani 2nd turn and scala vestibuli basal turn, 434 (range: 373-514) for scala media basal turn, and 590 (range: 546-643) for scala tympani basal turn. The resistivity was 455 Omega cm (range: 426-487) for the modiolus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Kumar, Gagan; Chokshi, Moulin; Richter, Claus-Peter] Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60611 USA.
[Richter, Claus-Peter] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA.
[Richter, Claus-Peter] Northwestern Univ, Dept Commun Sci & Disorders, Hugh Knowles Ctr, Evanston, IL 60208 USA.
RP Richter, CP (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol Head & Neck Surg, 303 E Chicago Ave, Chicago, IL 60611 USA.
EM cri529@northwestern.edu
FU National Science Foundation; American Hearing Research Foundation
FX This work was funded in part by a grant from the National Science
Foundation and in part by the American Hearing Research Foundation.
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NR 28
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 86
EP 94
DI 10.1016/j.heares.2009.10.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100009
PM 19857561
ER
PT J
AU Friesen, LM
Picton, TW
AF Friesen, Lendra M.
Picton, Terence W.
TI A method for removing cochlear implant artifact
SO HEARING RESEARCH
LA English
DT Article
DE N1; P2; ERP; Evoked potential; CAEP; Cochlear implant; Artifact
ID AUDITORY-EVOKED-POTENTIALS; NERVE ACTION-POTENTIALS; MISMATCH
NEGATIVITY; ACOUSTIC CHANGE; CORTICAL POTENTIALS; STIMULUS ARTIFACT;
CHANGE COMPLEX; HUMAN CORTEX; N1 WAVE; RESPONSES
AB When cortical auditory evoked potentials (CAEPs) are recorded in individuals with a cochlear implant (CI), electrical artifact can make the CAEP difficult or impossible to measure. Since increasing the inter-stimulus interval (ISI) increases the amplitude of physiological responses without changing the artifact, subtracting CAEPs recorded with a short ISI from those recorded with a longer ISI should show the physiological response without any artifact. In the first experiment, N1-P2 responses were recorded using a speech syllable and tone, paired with ISIs that changed randomly between 0.5 and 4 s. In the second experiment, the same stimuli, at ISIs of either 500 or 3000 ms, were presented in blocks that were homogeneous or random with respect to the ISI or stimulus. in the third experiment, N1-P2 responses were recorded using pulse trains with 500 and 3000 ms ISIs in 4 CI listeners. The results demonstrated: (1) N1-P2 response amplitudes generally increased with increasing ISI. (2) Difference waveforms were largest for the homogeneous and random-stimulus blocks than for the random-ISI block. (3) The subtraction technique almost completely eliminated the electrical artifact in individuals with cochlear implants. Therefore, the subtraction technique is a feasible method of removing from the N1-P2 response the electrical artifact generated by the cochlear implant. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Friesen, Lendra M.] Sunnybrook Hlth Sci Ctr, Dept Otolaryngol, Toronto, ON M4N 3M5, Canada.
Univ Toronto, Toronto, ON, Canada.
RP Friesen, LM (reprint author), Sunnybrook Hlth Sci Ctr, Dept Otolaryngol, Rm M1-102,2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM lendra.friesen@sunnybrook.ca
FU Hearing Foundation of Canada; University of Toronto Faculty of Medicine;
Canadian Institutes of Health Research
FX The authors wish to thank the subjects who participated in these
experiments for their time and effort. We would also like to thank
Patricia Van Roon and Kaibao Nie for their technical assistance. This
research was supported by the Hearing Foundation of Canada, the Dean's
Fund of the University of Toronto Faculty of Medicine, and the Canadian
Institutes of Health Research. Portions of this paper were presented at
the 21st International Evoked Response Audiometry Study Group Meeting
and at the 2009 Conference on Implantable Auditory Prosthesis.
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NR 75
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 95
EP 106
DI 10.1016/j.heares.2009.10.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100010
PM 19878712
ER
PT J
AU Okazaki, S
Kanoh, S
Tsukada, M
Oka, K
AF Okazaki, Shuntaro
Kanoh, Shin'ichiro
Tsukada, Minoru
Oka, Kotaro
TI Neural substrate of sound duration discrimination during an auditory
sequence in the guinea pig primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Sound duration; Change detection; Mismatch negativity; Unit recording;
Guinea pig
ID BIG BROWN BAT; EVENT-RELATED POTENTIALS; MISMATCH NEGATIVITY MMN;
INFERIOR COLLICULUS; EPTESICUS-FUSCUS; TONE DURATION; MEMORY-TRACE;
NEURONS; CAT; STIMULI
AB Mismatch negativity (MMN) is a negative component of event-related brain potentials elicited by stimulus transitions. Stimulus duration transition also elicits MMN (duration MMN), with a magnitude that is related to the degree of duration change and the discrimination ability. The neural substrates of duration MMN have not yet been investigated. We therefore studied how duration transitions in an auditory stimulus train are represented in neurons in the primary auditory cortex of anesthetized guinea pigs. Two types of neuronal responses to the context of changes in stimulus duration were found. One was a reduced response as the duration of the preceding stimulus was increased. Second was an enhancement of the late components of the response including sustained and offset responses at the duration transition. The former may be explained by the previously proposed two-tone suppression, which is dependent on the preceding stimulus duration. The latter is likely to be caused by stimulus-specific adaptation that could be a possible neural generator of duration MMN. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Oka, Kotaro] Keio Univ, Sch Fundamental Sci & Technol, Grad Sch Sci & Technol, Kohoku Ku, Kanagawa 2238522, Japan.
[Okazaki, Shuntaro] Natl Rehabil Ctr Persons Disabil, Res Inst, Dept Rehabil Sensory Funct, Saitama, Japan.
[Kanoh, Shin'ichiro] Tohoku Univ, Grad Sch Engn, Dept Elect Engn, Sendai, Miyagi 980, Japan.
[Tsukada, Minoru] Tamagawa Univ, Fac Engn, Tokyo, Japan.
RP Oka, K (reprint author), Keio Univ, Sch Fundamental Sci & Technol, Grad Sch Sci & Technol, Kohoku Ku, 3-14-1 Hiyoshi, Kanagawa 2238522, Japan.
EM oka@bio.keio.ac.jp
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NR 46
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2010
VL 259
IS 1-2
BP 107
EP 116
DI 10.1016/j.heares.2009.10.011
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 560DL
UT WOS:000274882100011
PM 19857562
ER
PT J
AU Krueger, J
Royal, DW
Fister, MC
Wallace, MT
AF Krueger, Juliane
Royal, David W.
Fister, Matthew C.
Wallace, Mark T.
TI Spatial receptive field organization of multisensory neurons and its
impact on multisensory interactions
SO HEARING RESEARCH
LA English
DT Article
DE Polysensory; Cat; Cross-modal; Multimodal; Integration
ID CAT SUPERIOR COLLICULUS; ANTERIOR ECTOSYLVIAN CORTEX; EYE-MOVEMENTS;
SOMATOSENSORY CONVERGENCE; OUTPUT NEURONS; VISUAL-CORTEX; DEEP LAMINAE;
INTEGRATION; AREA; CONNECTIONS
AB Previous work has established that the spatial receptive fields (SRFs) of multisensory neurons in the cerebral cortex are strikingly heterogeneous, and that SRF architecture plays an important deterministic role in sensory responsiveness and multisensory integrative capacities. The initial part of this contribution serves to review these findings detailing the key features of SRF organization in cortical multisensory populations by highlighting work from the cat anterior ectosylvian sulcus (AES). In addition, we have recently conducted parallel studies designed to examine SRF architecture in the classic model for multisensory studies, the cat superior colliculus (SC), and we present some of the preliminary observations from the SC here. An examination of individual SC neurons revealed marked similarities between their unisensory (i.e., visual and auditory) SRFs, as well as between these unisensory SRFs and the multisensory SRF. Despite these similarities within individual neurons, different SC neurons had SRFs that ranged from a single area of greatest activation (hot spot) to multiple and spatially discrete hot spots. Similar to cortical multisensory neurons, the interactive profile of SC neurons was correlated strongly to SRF architecture, closely following the principle of inverse effectiveness. Thus, large and often superadditive multisensory response enhancements were typically seen at SRF locations where visual and auditory stimuli were weakly effective. Conversely, subadditive interactions were seen at SRF locations where stimuli were highly effective. Despite the unique functions characteristic of cortical and subcortical multisensory circuits, our results suggest a strong mechanistic interrelationship between SRF microarchitecture and integrative capacity. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Krueger, Juliane; Royal, David W.; Wallace, Mark T.] Vanderbilt Univ, Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA.
[Fister, Matthew C.; Wallace, Mark T.] Vanderbilt Univ, Dept Hearing & Speech Sci, Nashville, TN 37232 USA.
RP Krueger, J (reprint author), Vanderbilt Univ, Kennedy Ctr Res Human Dev, 7110 MRB 3, Nashville, TN 37232 USA.
EM juliane.krueger@vanderbilt.edu
FU National Institute of Mental Health [MH-63861]; Vanderbilt Kennedy
Center for Research on Human Development
FX This work was supported by the National Institute of Mental Health Grant
MH-63861 and by the Vanderbilt Kennedy Center for Research on Human
Development. We acknowledge the technical expertise of Zachary Barnett.
We also thank LuAnn Toy and Troy Apple, DVM for their expert assistance
with animal care.
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NR 36
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 47
EP 54
DI 10.1016/j.heares.2009.08.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900006
PM 19698773
ER
PT J
AU Bizley, JK
King, AJ
AF Bizley, Jennifer K.
King, Andrew J.
TI Visual influences on ferret auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Spatial processing; Multisensory; Vision; Audition; Mutual information;
Auditory cortex; Visual cortex; Auditory-visual; Anatomy; Spatial
ID SUPERIOR TEMPORAL PLANE; MULTISENSORY CONVERGENCE; SOUND LOCALIZATION;
MUSTELA-PUTORIUS; COOLING DEACTIVATION; ANATOMICAL EVIDENCE; LAMINAR
PROFILE; STRIATE CORTEX; MACAQUE MONKEY; SULCAL CORTEX
AB Multisensory neurons are now known to be widespread in low-level regions of the cortex usually thought of as being responsible for modality-specific processing. The auditory cortex provides a particularly striking example of this, exhibiting responses to both visual and somatosensory stimulation. Single-neuron recording studies in ferrets have shown that each of auditory fields that have been characterized using physiological and anatomical criteria also receives visual inputs, with the incidence of visually-sensitive neurons ranging from 15% to 20% in the primary areas to around 50% or more in higher-level areas. Although some neurons exhibit spiking responses to visual stimulation, these inputs often have subthreshold influences that modulate the responses of the cortical neurons to sound. Insights into the possible role played by the visual inputs can be obtained by examining their sources of origin and the way in which they alter the processing capabilities of neurons in the auditory cortex These studies suggest that one of the functions of the visual input to auditory cortex is to sharpen the relatively imprecise spatial coding typically found there. Because the extent to which this happens varies between cortical fields, the investigation of multisensory interactions can also help in understanding their relative contributions to auditory perception. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bizley, Jennifer K.; King, Andrew J.] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England.
RP Bizley, JK (reprint author), Univ Oxford, Dept Physiol Anat & Genet, Sherrington Bldg,Parks Rd, Oxford OX1 3PT, England.
EM jennifer.bizley@dpag.ox.ac.uk
RI King, Andrew/M-6708-2013
OI King, Andrew/0000-0001-5180-7179
FU Wellcome Trust; Principal Research Fellowship; Biotechnology and
Biological Sciences Research Council [BB/D009758/1]
FX Supported by the Wellcome Trust through a Principal Research Fellowship
to A.J. King and the Biotechnology and Biological Sciences Research
Council (Grant BB/D009758/1).
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NR 62
TC 30
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 55
EP 63
DI 10.1016/j.heares.2009.06.017
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900007
PM 19595754
ER
PT J
AU Meredith, MA
Allman, BL
Keniston, LP
Clemo, HR
AF Meredith, M. Alex
Allman, Brian L.
Keniston, Leslie P.
Clemo, H. Ruth
TI Auditory influences on non-auditory cortices
SO HEARING RESEARCH
LA English
DT Article
DE Vision; Somatosensation; Multisensory; Subthreshold; Modulation
ID ANTERIOR ECTOSYLVIAN SULCUS; SUPERIOR TEMPORAL SULCUS; PRIMARY
VISUAL-CORTEX; RAT PARIETOTEMPORAL CORTEX; FERRET MUSTELA-PUTORIUS; CAT
CEREBRAL-CORTEX; MACAQUE MONKEY; MULTISENSORY CONVERGENCE; ASSOCIATION
CORTEX; EVOKED-POTENTIALS
AB Although responses to auditory stimuli have been extensively examined in the well-known regions of auditory cortex, there are numerous reports of acoustic sensitivity in cortical areas that are dominated by other sensory modalities. Whether in 'polysensory' cortex or in visual or somatosensory regions, auditory responses in non-auditory cortex have been described largely in terms of auditory processing. This review takes a different perspective that auditory responses in non-auditory cortex, either through multisensory subthreshold or bimodal processing, provide subtle but consistent expansion of the range of activity of the dominant modality within a given area. Thus, the features of these acoustic responses may have more to do with the subtle adjustment of response gain within a given non-auditory region than the encoding of their tonal properties. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Meredith, M. Alex; Allman, Brian L.; Keniston, Leslie P.; Clemo, H. Ruth] Virginia Commonwealth Univ, Sch Med, Dept Anzat & Neurobiol, Richmond, VA 23298 USA.
RP Meredith, MA (reprint author), Virginia Commonwealth Univ, Sch Med, Dept Anzat & Neurobiol, Med Coll Virginia Campus, Richmond, VA 23298 USA.
EM mameredi@vcu.edu
FU NIH [NS039460]
FX Supported by NIH Grant l.
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NR 59
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 64
EP 71
DI 10.1016/j.heares.2009.03.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900008
PM 19303926
ER
PT J
AU Musacchia, G
Schroeder, CE
AF Musacchia, Gabriella
Schroeder, Charles E.
TI Neuronal mechanisms, response dynamics and perceptual functions of
multisensory interactions in auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Auditory cortex; Multisensory; Neuroanatomy; Somatosensory; Oscillations
ID SUPERIOR TEMPORAL PLANE; MEDIAL BELT REGIONS; MACAQUE MONKEY; CORTICAL
CONNECTIONS; RHESUS-MONKEY; VISUAL SPEECH; THALAMOCORTICAL CONNECTIONS;
AUDIOTACTILE INTERACTION; SOMATOSENSORY INPUT; EVOKED RESPONSES
AB Most auditory events in nature are accompanied by non-auditory signals, such as a view of the speaker's face during face-to-face communication or the vibration of a string during a musical performance. While it is known that accompanying visual and somatosensory signals can benefit auditory perception, often by making the sound seem louder, the specific neural bases for sensory amplification are still debated. In this review, we want to deal with what we regard as confusion on two topics that are crucial to our understanding of multisensory integration mechanisms in auditory cortex: (1) Anatomical Underpinnings (e.g., what circuits underlie multisensory convergence), and (2) Temporal Dynamics (e.g., what time windows of integration are physiologically feasible). The combined evidence on multisensory structure and function in auditory cortex advances the emerging view of the relationship between perception and low level multisensory integration. In fact, it seems that the question is no longer whether low level, putatively unisensory cortex is accessible to multisensory influences, but how. (C) 2009 Published by Elsevier B.V.
C1 [Musacchia, Gabriella; Schroeder, Charles E.] Nathan S Kline Inst Psychiat Res, Cognit Neurosci & Neuroimaging Lab, Cognit Neurosci & Schizophrenia Program, Orangeburg, NY 10962 USA.
[Schroeder, Charles E.] Columbia Univ Coll Phys & Surg, Dept Psychiat, Orangeburg, NY 10962 USA.
RP Musacchia, G (reprint author), Nathan S Kline Inst Psychiat Res, Cognit Neurosci & Neuroimaging Lab, Cognit Neurosci & Schizophrenia Program, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA.
EM gmusacchia@gmail.com; Schrod@nki.rfmh.org
FU National Institutes of Health [DC 09918, MH 61989]
FX We would like to thank our colleagues Tammy McGinnis, M. Noelle O'Connel
and Aimee Mills for their assistance. We also thank Peter Lakatos,
Arnaud Falchier and Troy A. Hackett for their helpful comments and
suggestions. This work was supported by the National Institutes of
Health DC 09918 and MH 61989.
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NR 93
TC 33
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 72
EP 79
DI 10.1016/j.heares.2009.06.018
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900009
PM 19595755
ER
PT J
AU Recanzone, GH
AF Recanzone, Gregg H.
TI Interactions of auditory and visual stimuli in space and time
SO HEARING RESEARCH
LA English
DT Article
DE Perception; Auditory cortex; Vision; Multisensory
ID TEMPORAL RATE PERCEPTION; SOUND-LOCALIZATION; MACAQUE MONKEY;
CORTICAL-NEURONS; APPARENT MOTION; RHESUS-MONKEY; CORTEX; VENTRILOQUISM;
INTENSITY; FLICKER
AB The nervous system has evolved to transduce different types of environmental energy independently, for example light energy is transduced by the retina whereas sound energy is transduced by the cochlea. However, the neural processing of this energy is necessarily combined, resulting in a unified percept of a real-world object or event. These percepts can be modified in the laboratory, resulting in illusions that can be used to probe how multisensory integration occurs. This paper reviews studies that have utilized such illusory percepts in order to better understand the integration of auditory and visual signals in primates. Results from human psychophysical experiments where visual stimuli alter the perception of acoustic space (the ventriloquism effect) are discussed, as are experiments probing the underlying cortical mechanisms of this integration. Similar psychophysical experiments where auditory stimuli alter the perception of visual temporal processing are also described. (C) 2009 Elsevier B.V. All rights reserved
C1 [Recanzone, Gregg H.] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
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RP Recanzone, GH (reprint author), Ctr Neurosci, 1544 Newton Ct, Davis, CA 95618 USA.
EM ghrecanzone@ucdavis.edu
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NR 65
TC 38
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 89
EP 99
DI 10.1016/j.heares.2009.04.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900011
PM 19393306
ER
PT J
AU Maier, JX
Groh, JM
AF Maier, Joost X.
Groh, Jennifer M.
TI Multisensory guidance of orienting behavior
SO HEARING RESEARCH
LA English
DT Article
DE Reference frame; Representational format; Superior colliculus; Inferior
colliculus; Auditory cortex; Multisensory; Orienting behavior
ID PRIMATE SUPERIOR COLLICULUS; SACCADIC EYE-MOVEMENTS; AUDITORY
CORTICAL-NEURONS; POSTERIOR PARIETAL CORTEX; HEAD GAZE SHIFTS;
SOUND-LOCALIZATION; INFERIOR COLLICULUS; HUMAN LISTENERS; MACAQUE
MONKEY; SENSORIMOTOR INTEGRATION
AB We use both vision and audition when localizing objects and events in our environment. However, these sensory systems receive spatial information in different coordinate systems: sounds are localized using inter-aural and spectral cues, yielding a head-centered representation of space, whereas the visual system uses an eye-centered representation of space, based on the site of activation on the retina. In addition, the visual system employs a place-coded, retinotopic map of space, whereas the auditory system's representational format is characterized by broad spatial tuning and a lack of topographical organization. A common view is that the brain needs to reconcile these differences in order to control behavior, such as orienting gaze to the location of a sound source. To accomplish this, it seems that either auditory spatial information must be transformed from a head-centered rate code to an eye-centered map to match the frame of reference used by the visual system, or vice versa. Here, we review a number of studies that have focused on the neural basis underlying such transformations in the primate auditory system. Although, these studies have found some evidence for such transformations, many differences in the way the auditory and visual system encode space exist throughout the auditory pathway. We will review these differences at the neural level, and will discuss them in relation to differences in the way auditory and visual information is used in guiding orienting movements. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Maier, Joost X.; Groh, Jennifer M.] Duke Univ, Ctr Cognit Neurosci, Dept Neurobiol, Dept Psychol & Neurosci, Durham, NC 27708 USA.
RP Maier, JX (reprint author), Duke Univ, Ctr Cognit Neurosci, Dept Neurobiol, Dept Psychol & Neurosci, LSRC B203, Durham, NC 27708 USA.
EM joost.maier@gmail.com
FU [NS50942-01]; [NSF0415634]; [EY016478]
FX The authors thank Dave Bulkin for valuable discussions. This work was
supported by NS50942-01, NSF0415634, EY016478 to JMG.
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NR 85
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 106
EP 112
DI 10.1016/j.heares.2009.05.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900013
PM 19520151
ER
PT J
AU Spence, C
Santangelo, V
AF Spence, Charles
Santangelo, Valerio
TI Capturing spatial attention with multisensory cues: A review
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LA English
DT Article
DE Multisensory perception; Spatial attention; Exogenous orienting;
Hearing; Touch; Vision; Psychophysics; ERP
ID WORKING-MEMORY LOAD; VISUAL-ATTENTION; SUPERIOR COLLICULUS; SELECTIVE
ATTENTION; TACTILE ATTENTION; ILLUSORY LOCATION; TASK-IRRELEVANT;
EXOGENOUS CUES; REACTION-TIME; NEURAL BASIS
AB The last 30 years have seen numerous studies demonstrating unimodal and crossmodal spatial cuing effects. However, surprisingly few studies have attempted to investigate whether multisensory cues might be any more effective in capturing a person's spatial attention than unimodal cues. Indeed, until very recently, the consensus view was that multisensory cues were, in fact, no more effective. However, the results of several recent studies have overturned this conclusion, by showing that multisensory cues retain their attention-capturing ability under conditions of perceptual load (i.e., when participants are simultaneously engaged in a concurrent attention-demanding task) while their constituent signals (when presented unimodally) do not. Here we review the empirical literature on multisensory spatial cuing effects and highlight the implications that this research has for the design of more effective warning signals in applied settings. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Spence, Charles] Univ Oxford, Dept Expt Psychol, Crossmodal Res Lab, Oxford OX1 3UD, England.
[Santangelo, Valerio] Univ Perugia, Dept Human & Educ Sci, I-06100 Perugia, Italy.
RP Spence, C (reprint author), Univ Oxford, Dept Expt Psychol, Crossmodal Res Lab, S Parks Rd, Oxford OX1 3UD, England.
EM charles.spence@psy.ox.ac.uk
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NR 95
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
BP 134
EP 142
DI 10.1016/j.heares.2009.04.015
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900016
PM 19409472
ER
PT J
AU Besle, J
Bertrand, O
Giard, MH
AF Besle, Julien
Bertrand, Olivier
Giard, Marie-Helene
TI Electrophysiological (EEG, sEEG, MEG) evidence for multiple audiovisual
interactions in the human auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Auditory; Visual; Multisensory; Intracranial; Speech; Human; ERPs
ID MISMATCH NEGATIVITY MMN; BIMODAL DIVIDED ATTENTION; SHORT-TERM-MEMORY;
VISUAL SPEECH; MULTISENSORY INTEGRATION; HUMAN BRAIN; FEATURE
CONJUNCTIONS; SELECTIVE ATTENTION; SENSORY MEMORY; SEEING SPEECH
AB In this review, we examine the contribution of human electrophysiological studies (EEG sEEG and MEG), to the study of visual influence on processing in the auditory cortex. Focusing mainly on studies performed by our group, we critically review the evidence showing (1) that visual information can both activate and modulate the activity of the auditory cortex at relatively early stages (mainly at the processing stage of the auditory N1 wave) in response to both speech and non-speech sounds and (2) that visual information can be included in the representation of both speech and non-speech sounds in auditory sensory memory. We describe an important conceptual tool in the study of audiovisual interaction (the additive model) and show the importance of considering the spatial distribution of electrophysiological data when interpreting EEG results. Review of these studies points to the probable role of sensory, attentional and task-related factors in modulating audiovisual interactions in the auditory cortex. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Besle, Julien] Univ Lyon 1, INSERM, U821, F-69500 Bron, France.
[Besle, Julien; Bertrand, Olivier; Giard, Marie-Helene] Univ Lyon 1, F-69000 Lyon, France.
[Besle, Julien] Univ Lyon 2, F-69000 Lyon, France.
RP Besle, J (reprint author), Univ Lyon 1, INSERM, U821, F-69500 Bron, France.
EM julien.besle@inserm.fr
RI Besle, Julien/A-8262-2014; Bertrand, Olivier/B-6165-2008
OI Besle, Julien/0000-0002-8792-1712;
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NR 71
TC 32
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
SI SI
BP 143
EP 151
DI 10.1016/j.heares.2009.06.016
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900017
PM 19573583
ER
PT J
AU van Atteveldt, N
Roebroeck, A
Goebel, R
AF van Atteveldt, Nienke
Roebroeck, Alard
Goebel, Rainer
TI Interaction of speech and script in human auditory cortex: Insights from
neuro-imaging and effective connectivity
SO HEARING RESEARCH
LA English
DT Article
DE fMRI; Auditory cortex; Audiovisual; Speech; Script; Multisensory
integration; Granger causality mapping
ID GRAPHEME-PHONEME CORRESPONDENCE; SUPERIOR TEMPORAL SULCUS; HUMAN
VISUAL-CORTEX; HUMAN BRAIN; MULTISENSORY INTEGRATION; FUNCTIONAL
CONNECTIVITY; CORTICAL OSCILLATIONS; MISMATCH NEGATIVITY;
READING-DISABILITY; COMPONENT ANALYSIS
AB In addition to visual information from the face of the speaker, a less natural, but nowadays extremely important visual component of speech is its representation in script. In this review, neuro-imaging studies are examined which were aimed to understand how speech and script are associated in the adult "literate" brain. The reviewed studies focused on the role of different stimulus and task factors and effective connectivity between different brain regions. The studies will be summarized in a neural mechanism for the integration of speech and script that can serve as a basis for future studies addressing (the failure of) literacy acquisition. In this proposed mechanism, speech sound processing in auditory cortex is modulated by co-presented visual letters, depending on the congruency of the letter-sound pairs. Other factors of influence are temporal correspondence, input quality and task instruction. We present results showing that the modulation of auditory cortex is most likely mediated by feedback from heteromodal areas in the superior temporal cortex, but direct influences from visual cortex are not excluded. The influence of script on speech sound processing occurs automatically and shows extended development during reading acquisition. This review concludes with suggestions to answer currently still open questions to get closer to understanding the neural basis of normal and impaired literacy. (C) 2009 Elsevier B.V. All rights reserved.
C1 [van Atteveldt, Nienke] Columbia Univ Coll Phys & Surg, Div Child & Adolescent Psychiat, Dept Psychiat, New York, NY 10032 USA.
[van Atteveldt, Nienke] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[van Atteveldt, Nienke; Roebroeck, Alard; Goebel, Rainer] Maastricht Univ, Fac Psychol & Neurosci, Dept Cognit Neurosci, NL-6200 MD Maastricht, Netherlands.
[Goebel, Rainer] Netherlands Inst Neurosci, NL-1105 BA Amsterdam, Netherlands.
RP van Atteveldt, N (reprint author), Columbia Univ Coll Phys & Surg, Div Child & Adolescent Psychiat, Dept Psychiat, 1051 Riverside Dr, New York, NY 10032 USA.
EM n.vanatteveldt@maastrichtuniversity.nl;
a.roebroeck@maastrichtuniversity.nl; r.goebel@maastrichtuniversity.nl
FU Dutch Organization for Scientific Research [451-07-020]; European
Community's Seventh Framework Programme [221187]
FX This work is supported by the Dutch Organization for Scientific Research
(NWO, VENI Grant # 451-07-020 to N.v.A.) and the European Community's
Seventh Framework Programme ([FP/2007-2013] Grant # 221187 to N.v.A.).
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NR 99
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2009
VL 258
IS 1-2
SI SI
BP 152
EP 164
DI 10.1016/j.heares.2009.05.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 535IL
UT WOS:000272960900018
PM 19500658
ER
PT J
AU Wild, JM
Krutzfeldt, NOE
Kubke, MF
AF Wild, J. M.
Kruetzfeldt, N. O. E.
Kubke, M. F.
TI Afferents to the cochlear nuclei and nucleus laminaris from the ventral
nucleus of the lateral lemniscus in the zebra finch (Taeniopygia
guttata)
SO HEARING RESEARCH
LA English
DT Article
DE Auditory brainstem; Songbird; Avian; Superior olive
ID INTERAURAL TIME DIFFERENCES; SUPERIOR OLIVARY NUCLEUS; STEM AUDITORY
NUCLEI; BRAIN-STEM; BARN OWL; PROJECTIONS; CHICK; IMMUNOREACTIVITY;
NEURONS; BASALIS
AB The presence and nature of a descending projection from the ventral nucleus of the lateral lemniscus (LLV) to the cochlear nuclei (NA, NM) and the third-order nucleus laminaris (NL) was investigated in a songbird using tract tracing and GAD immunohistochemistry. Tracer injections into LLV produced anterograde label in the ipsilateral NA, NM and NL, which was found not to be GABAergic. Double retrograde labeling from LLV and NA/NM/NL ruled out the possibility that the LLV projection actually arose from collaterals of superior olivary projections to NA/NM/NL. The LLV projection may be involved in the discrimination of laterality of auditory input. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Wild, J. M.; Kruetzfeldt, N. O. E.; Kubke, M. F.] Univ Auckland, Fac Med & Hlth Sci, Dept Anat Radiol, Sch Med Sci, Auckland 1, New Zealand.
RP Wild, JM (reprint author), Univ Auckland, Fac Med & Hlth Sci, Dept Anat, PB 92019, Auckland 1, New Zealand.
EM jm.wild@auckland.ac.nz
RI Kubke, Maria Fabiana/E-2472-2011; Kubke, M Fabiana/H-3320-2012
FU Royal Society of New Zealand Marsden
FX Funded by a grant from the Royal Society of New Zealand Marsden Fund to
J.M. Wild. We thank Silke Fuchs for histological assistance.
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NR 31
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 1
EP 7
DI 10.1016/j.heares.2009.07.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200001
PM 19631727
ER
PT J
AU Lin, CY
Wu, JL
Shih, TS
Tsai, PJ
Sun, YM
Guo, YL
AF Lin, Cheng-Yu
Wu, Jiunn-Liang
Shih, Tung-Sheng
Tsai, Perng-Jy
Sun, Yih-Min
Guo, Yueliang Leon
TI Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility
factors for noise-induced temporary threshold shift
SO HEARING RESEARCH
LA English
DT Article
DE Temporary threshold shift; Glutathione S-transferase; Single nucleotide
polymorphism
ID INDUCED HEARING-LOSS; GENETIC POLYMORPHISMS; ENZYME-ACTIVITY;
RISK-FACTORS; CANCER RISK; INCREASES SUSCEPTIBILITY; EPOXIDE HYDROLASE;
OXIDATIVE STRESS; LIVER-CIRRHOSIS; AIR-POLLUTION
AB The generation of reactive oxygen species (ROS) is thought to be part of the mechanism underlying noise-induced hearing loss (NIHL). Glutathione is an important cellular antioxidant that limits cell damage by ROS. We aimed to determine the effect of genetic polymorphisms of glutathione S-transferase (GST) T1, GSTM1, and GSTP1, on temporary threshold shift (TTS) in 58 noise-exposed male workers from a steel factory. The pre-shift hearing impairment at high frequency (HF, average of 3, 4, and 6 kHz) was 30.7 dB HL (S.D. = 19.3). The amount of daily noise exposure was 83.0 dBA (S.D. = 5.0). Noise-induced TTS at HF by pure-tone audiometry (PTA) was related to the daily noise exposure (p < 0.05). Based on combinatory analysis, we found that individuals carrying all genotypes with GSTT1 null, GSTM1 null, and GSTP1 Ile(105)/Ile(105) were more susceptible to NIHL These results suggest that pre-shift hearing impairment and daily noise exposure had impacts on TTS at HF by PTA. In addition, GST genetic polymorphisms may modify the susceptibility to noise-induced TTS. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Guo, Yueliang Leon] Natl Taiwan Univ, Dept Environm & Occupat Med, Coll Med, Taipei 100, Taiwan.
[Guo, Yueliang Leon] NTU Hosp, Taipei 100, Taiwan.
[Lin, Cheng-Yu] Tainan Municipal Hosp, Dept Otolaryngol, Tainan 701, Taiwan.
[Lin, Cheng-Yu; Tsai, Perng-Jy] Natl Cheng Kung Univ, Coll Med, Inst Environm & Occupat Hlth Med, Tainan 704, Taiwan.
[Wu, Jiunn-Liang] Natl Cheng Kung Univ, Coll Med, Dept Otolaryngol, Tainan 704, Taiwan.
[Shih, Tung-Sheng] Council Labor Affairs, Inst Occupat Safety & Hlth, Taipei 221, Taiwan.
[Sun, Yih-Min] Chung Hwa Univ Med Technol, Dept Occupat Safety & Hlth, Rende Township 717, Tainan County, Taiwan.
RP Guo, YL (reprint author), Natl Taiwan Univ, Dept Environm & Occupat Med, Coll Med, Room 339,17 Syujhou Rd, Taipei 100, Taiwan.
EM yu621109@ms48.hinet.net; jiunn@mail.ncku.edu.tw; stone@mail.iosh.gov.tw;
pjtsai@mail.ncku.edu.tw; swimming@mail.hwai.edu.tw; leonguo@ntu.edu.tw
FU Council of Labor Affairs; Executive Yuan; Tainan Municipal Hospital
FX The authors thank Miss Wen-Kuei Lin, Miss I.-Hui Lin, Miss Linda Chang,
and the staffs of the TeamBest Company and the Clinico Company for their
assistance in the preparation of this manuscript. This study was
supported by grants from the Council of Labor Affairs, the Executive
Yuan, and the Tainan Municipal Hospital.
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NR 77
TC 9
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 8
EP 15
DI 10.1016/j.heares.2009.07.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200002
PM 19643173
ER
PT J
AU Lu, E
Llano, DA
Sherman, SM
AF Lu, E.
Llano, D. A.
Sherman, S. M.
TI Different distributions of calbindin and calretinin immunostaining
across the medial and dorsal divisions of the mouse medial geniculate
body
SO HEARING RESEARCH
LA English
DT Article
DE Thalamus; Cortex; Calcium; Intralaminar; Paralaminar; Auditory
ID CALCIUM-BINDING PROTEINS; THALAMIC NUCLEUS; STRIATAL PROJECTIONS; RELAY
NEURONS; RAT; PARVALBUMIN; ORGANIZATION; IMMUNOREACTIVITY; AMYGDALA;
CORTEX
AB We studied the distributions of calretinin and calbindin immunoreactivity in subdivisions of the mouse medial geniculate body and the adjacent paralaminar nuclei. We found that the vast majority of labeled cells in the dorsal division of the medial geniculate body were immunoreactive for calbindin-only, whereas most of the remaining labeled cells were double-labeled. Very few calretinin+ only cells were observed. By contrast, we observed significant proportions of calbindin+ only, calretinin+ only and double-labeled cells in the medial division of the medial geniculate body. Further, the distributions of calbindin-only, calretinin-only and double-labeled cells did not differ between the medial division of the medial geniculate body, the suprageniculate nucleus, the peripeduncular nucleus and the posterior intralaminar nucleus. We found essentially no somatic staining for either calbindin or calretinin in the ventral division of the medial geniculate body. These data suggest that there are distinct neurochemical differences between the two non-lemniscal auditory thalamic nuclei. In addition, these data extend previous observations that the medial division of the medial geniculate body shares many properties with the paralaminar group of nuclei. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Lu, E.; Llano, D. A.; Sherman, S. M.] Univ Chicago, Dept Neurobiol, Chicago, IL 60637 USA.
[Llano, D. A.] Univ Chicago, Dept Neurol, Chicago, IL 60637 USA.
[Llano, D. A.] Abbott Labs, Abbott Pk, IL 60064 USA.
RP Llano, DA (reprint author), Univ Chicago, Dept Neurobiol, 549 E 58th St MC 0926, Chicago, IL 60637 USA.
EM a.daniel.llano@gmail.com
FU United States Public Health Service, NIH [DC008320, EY03038, DC008794]
FX The authors thank Angelia Viaene for her technical assistance in the
work. The authors obtained funding from the United States Public Health
Service, NIH, Grants DC008320 (D.A.L.), EY03038 and DC008794 (S.M.S.).
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NR 47
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 16
EP 23
DI 10.1016/j.heares.2009.07.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200003
PM 19643174
ER
PT J
AU Pienkowski, M
Eggermont, JJ
AF Pienkowski, Martin
Eggermont, Jos J.
TI Long-term, partially-reversible reorganization of frequency tuning in
mature cat primary auditory cortex can be induced by passive exposure to
moderate-level sounds
SO HEARING RESEARCH
LA English
DT Article
DE Auditory cortex; Plasticity; Passive sound exposure; Extracellular
recording; Single-unit activity; Local field potential; Receptive field;
Tonotopic map
ID SPECTROTEMPORAL RECEPTIVE-FIELDS; CRITICAL-PERIOD; COCHLEAR LESIONS;
ADULT CATS; CORTICAL PLASTICITY; ORGANIZATION; ENVIRONMENT; NEURONS;
REPRESENTATION; POTENTIATION
AB We recently reported that passive exposure for at least 4 months of adult cats to a two-octave-wide tone pip ensemble at 80 dB SPL, decreased the responsiveness of primary auditory cortex (AI) to sound frequencies in the exposure band, and increased the responsiveness to frequencies at the outer edges of the band. Here we expand on this by demonstrating qualitatively similar plasticity for a 6-week exposure level of 68 dB SPL Though no peripheral hearing loss is induced by the exposure, the resulting reorganization of the AI tonotopic map resembles that following a restricted lesion of the sensory epithelium. Most exposure-induced effects were likely present in the thalamus, as deduced from changes in local field potentials, but were further modified in AI. We then examined the potential for the reversal of these changes, given recovery in a quiet laboratory environment for up to 12 weeks after the cessation of exposure. While frequency tuning returned to near-normal, other neuronal response properties, as well as tonotopic map organization, remained abnormal at the end of our 12-week window. This could have implications for persistently noisy work/recreation/living environments, even at levels considerably below those presently considered unacceptable. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Eggermont, Jos J.] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM eggermon@ucalgary.ca
FU Alberta Heritage Foundation for Medical Research; Natural Sciences and
Engineering Research Council; Campbell McLaurin Chair of Hearing
Deiciencies
FX This work was supported by the Alberta Heritage Foundation for Medical
Research, by the Natural Sciences and Engineering Research Council, and
by the Campbell McLaurin Chair of Hearing Deiciencies. Arnaud Norena and
Boris Gourevich assisted with some of the data collection. Greg Shaw
provided programming support.
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NR 58
TC 36
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 24
EP 40
DI 10.1016/j.heares.2009.07.011
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200004
PM 19647789
ER
PT J
AU Howard, MF
Poeppel, D
AF Howard, Mary F.
Poeppel, David
TI Hemispheric asymmetry in mid and long latency neuromagnetic responses to
single clicks
SO HEARING RESEARCH
LA English
DT Article
DE Auditory; Evoked field; M100; N1m; Lateralization; MEG
ID HUMAN AUDITORY-CORTEX; EVOKED MAGNETIC-FIELDS; SENSORY MEMORY; TEMPORAL
INTEGRATION; SOURCE LOCALIZATION; VOLUME MEASUREMENT; HESCHLS GYRUS;
TONE BURSTS; POTENTIALS; SPEECH
AB We examine lateralization in the evoked magnetic field response to a click stimulus, observing that lateralization effects previously demonstrated for tones, noise, frequency modulated sweeps and certain syllables are also observed for (acoustically simpler) clicks. These effects include a difference in the peak latency of the M100 component of the evoked field waveform such that the peak consistently appears earlier in the right hemisphere, as well as rightward lateralization of field amplitude during the rise of the M100 component. Our review of previous findings on M100 lateralization, taken together with our data on the click-evoked response, leads to the hypothesis that these lateralization effects are elicited by stimuli containing a sharp sound energy onset or acoustic transition rather than specific types of stimuli. We argue that both the latency and the amplitude lateralization effects have a common origin, namely, hemispheric asymmetry in the amplitude of the magnetic field generated by one or more sources active during the M100 rise. While anatomical asymmetry cannot be excluded as the cause of the amplitude difference, we propose that the difference reflects a rightward asymmetry in the processing of sound energy onsets that potentially underlies the lateralization of several functions. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Howard, Mary F.; Poeppel, David] Univ Maryland, Dept Linguist, College Pk, MD 20742 USA.
[Poeppel, David] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Poeppel, David] NYU, Dept Psychol, New York, NY 10003 USA.
RP Howard, MF (reprint author), Univ Maryland, Dept Linguist, Biol Psychol Bldg 3263,1401 Marie Mt Hall, College Pk, MD 20742 USA.
EM mfhoward@umd.edu; david.poeppel@nyu.edu
FU National Institute of Deafness and Other Communication Disorders of the
National Institutes of Health [DC-00046, 2R01 DC05660]
FX We are grateful to J. Walker for excellent technical assistance. This
work was supported by the National Institute of Deafness and Other
Communication Disorders of the National Institutes of Health through
Training Grant DC-00046 to M. Howard and Grant 2R01 DC05660 to D.
Poeppel.
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NR 69
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 41
EP 52
DI 10.1016/j.heares.2009.07.010
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200005
PM 19647788
ER
PT J
AU Park, HJ
Kim, HJ
Bae, GS
Seo, SW
Kim, DY
Jung, WS
Kim, MS
Song, MY
Kim, EK
Kwon, KB
Hwang, SY
Song, HJ
Park, CS
Park, RK
Chong, MS
Park, SJ
AF Park, Hee-Je
Kim, Hyung-Jin
Bae, Gi-Sang
Seo, Sang-Wan
Kim, Do-Yun
Jung, Won-Seok
Kim, Min-Sun
Song, Mi-Young
Kim, Eun-Kyung
Kwon, Kang-Beom
Hwang, Sung-Yeon
Song, Ho-Joon
Park, Cheung-Seog
Park, Rae-Kil
Chong, Myong-Soo
Park, Sung-Joo
TI Selective GSK-3 beta inhibitors attenuate the cisplatin-induced
cytotoxicity of auditory cells
SO HEARING RESEARCH
LA English
DT Article
DE GSK-3; Ototoxicity; Cochlea; Hair cell; Hearing loss
ID GLYCOGEN-SYNTHASE KINASE-3; GROWTH-FACTOR WITHDRAWAL; NF-KAPPA-B;
INDUCED APOPTOSIS; C57BL/6 MICE; ORGANOTYPIC CULTURES; HAIR-CELLS;
PHOSPHORYLATION; ACTIVATION; DEATH
AB Glycogen synthase kinase-3 (GSK-3) plays an important role in the regulation of apoptosis. However, the role of GSK-3 in the auditory system remains unknown. Here we examined whether the GSK-3-specific inhibitors, SB 216763 and LiCl, could protect against cisplatin-induced cytotoxicity of auditory cells. GSK-3 was activated by cisplatin treatment of HEl-OC1 cells. SB 216763 or LiCl treatments inhibited cisplatin-induced apoptosis in a dose-dependent manner and activated caspase-9, -8 and -3. In rat primary explants of the organ of Corti, SB 216763 or LiCl treatments completely abrogated the cisplatin-induced destruction of outer hair cell arrays. Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and IL-6 in cisplatin-injected mice. Furthermore, administration of SB 216763 or LiCl reduced the thresholds of the auditory brainstem response (ABR) in cisplatin-injected mice. Collectively, these results suggest that cisplatin-induced otortoxicity might be associated with modulation of GSK-3 activation. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Park, Hee-Je; Bae, Gi-Sang; Seo, Sang-Wan; Kim, Do-Yun; Jung, Won-Seok; Kim, Min-Sun; Hwang, Sung-Yeon; Song, Ho-Joon; Park, Sung-Joo] Wonkwang Univ, Coll Oriental Med, Dept Herbol, Iksan, Jeonbuk, South Korea.
[Kim, Hyung-Jin; Park, Rae-Kil] Wonkwang Univ, Coll Med, Vestibulocochlear Res Ctr, Iksan, Jeonbuk, South Korea.
[Kim, Hyung-Jin; Park, Rae-Kil] Wonkwang Univ, Coll Med, Dept Microbiol, Iksan, Jeonbuk, South Korea.
[Seo, Sang-Wan; Park, Cheung-Seog] Kyung Hee Univ, Coll Med, Dept Microbiol, Seoul, South Korea.
[Song, Mi-Young; Kim, Eun-Kyung; Kwon, Kang-Beom] Wonkwang Univ, Coll Oriental Med, Dept Physiol, Iksan, Jeonbuk, South Korea.
[Chong, Myong-Soo] Wonkwang Univ, Coll Oriental Med, Dept Prevent Med, Iksan, Jeonbuk, South Korea.
RP Park, SJ (reprint author), Wonkwang Univ, Coll Oriental Med, Dept Herbol, Iksan, Jeonbuk, South Korea.
EM tajohj82@hanmail.net; enz94@hanmail.net; baegs888@hanmail.net;
jiluman@hanmail.net; doyun325@hanmail.net; starjungws@hanmail.net;
minsun.75@Gmail.com; white1696@nate.com; rei1325@nate.com;
desson@wku.ac.kr; kimsiblue@wonkwang.ac.kr; songhj@wonkwang.ac.kr;
pcs@khu.ac.kr; rkpark@wonkwang.ac.kr; neurokid@wku.ac.kr;
parksj08@wku.ac.kr
FU Ministry of Science & Technology (MoST)/Korea Science & Engineering
Foundation (KOSEF) through the Vestibulocochlear Research Center (VCRC)
[R13-2002-055-00000-0]
FX This work was supported by the Ministry of Science & Technology
(MoST)/Korea Science & Engineering Foundation (KOSEF) through the
Vestibulocochlear Research Center (VCRC) at Wonkwang University
(R13-2002-055-00000-0).
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NR 39
TC 18
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 53
EP 62
DI 10.1016/j.heares.2009.08.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200006
PM 19666099
ER
PT J
AU Melcher, JR
Levine, RA
Bergevin, C
Norris, B
AF Melcher, Jennifer R.
Levine, Robert A.
Bergevin, Christopher
Norris, Barbara
TI The auditory midbrain of people with tinnitus: Abnormal sound-evoked
activity revisited
SO HEARING RESEARCH
LA English
DT Article
DE Hyperacusis; Midbrain; Phantom sensation; fMRI; Neuroimaging
ID HUMAN BRAIN-STEM; FMRI ACTIVATION; PSYCHOMETRIC PROPERTIES; LATERALIZED
TINNITUS; INFERIOR COLLICULUS; NOISE EXPOSURE; ACOUSTIC NOISE; SCANNER
NOISE; LOUDNESS; PLASTICITY
AB Sound-evoked fMRI activation of the inferior colliculi (IC) was compared between tinnitus and non-tinnitus subjects matched in threshold (normal), age, depression, and anxiety. Subjects were stimulated with broadband sound in an "on/off" fMRI paradigm with and without on-going sound from the scanner coolant pump.
(1) With pump sounds off. the tinnitus; group showed greater stimulus-evoked activation of the IC than the non-tinnitus group, suggesting abnormal gain within the auditory pathway of tinnitus subjects.
(2) Having pump sounds on reduced activation in the tinnitus, but not the non-tinnitus; group. This result suggests response saturation in tinnitus subjects, possibly occurring because abnormal gain increased response amplitude to an upper limit.
(3) In contrast to Melcher et al. (2000), the ratio of activation between right and left IC did not differ significantly between tinnitus and non-tinnitus subjects or in a manner dependent on tinnitus laterality. However, new data from subjects imaged previously by Melcher et al. suggest a possible tinnitus subgroup with abnormally asymmetric function of the IC.
The present and previous data together suggest elevated responses to sound in the IC are common among those with tinnitus and normal thresholds, while abnormally asymmetric activation is not, even among those with lateralized tinnitus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Melcher, Jennifer R.; Levine, Robert A.; Bergevin, Christopher; Norris, Barbara] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Melcher, Jennifer R.; Bergevin, Christopher] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02139 USA.
[Melcher, Jennifer R.; Levine, Robert A.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Levine, Robert A.] Massachusetts Gen Hosp, Neurol Serv, Boston, MA 02114 USA.
RP Melcher, JR (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM jennifer_melcher@meei.harvard.edu
FU Tinnitus Research Consortium; American Tinnitus Association; Royal
National Institute for Deaf People; Tinnitus Research Initiative; Jack
and Shelley Blais; Kenneth Griffin; NIH/NIDCD [P30DC005209]; National
Center for Research Resources [P41RR14075]; Mental Illness and
Neuroscience Discovery (MIND) Institute
FX We thank Irina Sigalovsky for her assistance in performing some of the
experiments and Inge Knudson, Jianwen Gu and Christopher Shera for their
comments on an earlier version of this manuscript. Support was provided
by the Tinnitus Research Consortium, American Tinnitus Association,
Royal National Institute for Deaf People, Tinnitus Research Initiative,
Jack and Shelley Blais, Kenneth Griffin, and NIH/NIDCD P30DC005209.
Partial support was also provided by the National Center for Research
Resources (P41RR14075) and the Mental Illness and Neuroscience Discovery
(MIND) Institute.
CR ADJAMIAN P, 2009, HEARING RES
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NR 47
TC 40
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 63
EP 74
DI 10.1016/j.heares.2009.08.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200007
PM 19699287
ER
PT J
AU Luo, F
Wang, QZ
Farid, N
Liu, XP
Yan, J
AF Luo, Feng
Wang, Qianzhou
Farid, Niloufar
Liu, Xiuping
Yan, Jun
TI Three-dimensional tonotopic organization of the C57 mouse cochlear
nucleus
SO HEARING RESEARCH
LA English
DT Article
DE Auditory; Cochlear nucleus; Tonotopic map; Frequency tuning curve; Mouse
ID AUDITORY-NERVE FIBERS; INFERIOR COLLICULUS; HOUSE MOUSE; FREQUENCY
REPRESENTATION; CORTICOFUGAL MODULATION; QUANTITATIVE-ANALYSIS; RESPONSE
PROPERTIES; SINGLE NEURONS; TUNING CURVES; HEARING-LOSS
AB The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the general usefulness of the mouse, including the availability of various inbred strains and gene-manipulated lines, our current understanding of the mouse CN remains limited. The purpose of this study was to illustrate the functional organization of the CN in C57 mice, using an electrophysiological approach. Our results showed that the auditory response properties of CN neurons were similar in all three of the CN subdivisions. Sound frequency was systematically represented in each of the three CN subdivisions, i.e., the anteroventral, posteroventral and the dorsal divisions. The best frequency of CN neurons decreased along the dorsomedial-to-ventrolateral axis in an orderly progression whereas the tonotopic axes were relatively indistinct in the rostrocaudal plane. There was no disruption of the tonotopic map within each subdivision of the CN. The findings indicate, that the CN tonotopic organization in the C57 mouse is similar to that in the cat and other mammals. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Luo, Feng; Wang, Qianzhou; Farid, Niloufar; Liu, Xiuping; Yan, Jun] Univ Calgary, Dept Physiol & Pharmacol, Hotchkiss Brain Inst, Fac Med, Calgary, AB T2N 4N1, Canada.
RP Luo, F (reprint author), Univ Calgary, Dept Physiol & Pharmacol, Hotchkiss Brain Inst, Fac Med, HMRB 130,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM fluo@ucalgary.ca; juyan@ucalgary.ca
FU National Sciences and Engineering Research Council; University of
Calgary; Alberta Heritage Foundation for Medical Research
FX We thank Drs. William K. Stell and Alireza Kashani for their help in
histological work. This research is supported by the National Sciences
and Engineering Research Council, the Campbell McLaurin Chair for
Hearing Deficiencies of the University of Calgary and the Alberta
Heritage Foundation for Medical Research.
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NR 53
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 75
EP 82
DI 10.1016/j.heares.2009.08.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200008
PM 19695320
ER
PT J
AU Gutschalk, A
Oldermann, K
Rupp, A
AF Gutschalk, Alexander
Oldermann, Konstanze
Rupp, Andre
TI Rate perception and the auditory 40-Hz steady-state fields evoked by
two-tone sequences
SO HEARING RESEARCH
LA English
DT Article
DE Tonotopy; Auditory cortex; Streaming; Magnetoencephalography
ID STREAM SEGREGATION; TONOTOPIC ORGANIZATION; TONE SEQUENCES; AWAKE
MONKEY; 40 HZ; CORTEX; RESPONSES; DECONVOLUTION; POTENTIALS; ATTENTION
AB The rate perception of tone sequences reflects the physical repetition rate for identical sound elements. More complex sequences are perceived at the physical rate or at lower rates, depending on perceptual organization. Here, we used magnetoencephalography and psychophysical studies to evaluate the possible relationship between rate perception of such rapid, 40-Hz tone trains and the 40-Hz steady-state response (SSR) in human primary auditory cortex. In Experiment 1, the 40-Hz SSR evoked by monotone sequences of 1000 and 600 Hz were compared to the response evoked by alternating-tone sequences of the same frequencies. The results showed that the 40-Hz SSR for the alternating-tones was attenuated compared to the monotones. In Experiment 2, frequency differences across a range of 25-300 Hz were studied. Compared to a 1000-Hz monotone sequence, the 40-Hz SSR was reduced. Amplitude reduction was most prominent for frequency differences of 200 Hz and more, which were generally perceived with half-the-physical rate. We discuss possible physiological mechanisms of this finding and its relationship to perception. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Gutschalk, Alexander; Oldermann, Konstanze; Rupp, Andre] Univ Heidelberg, Dept Neurol, D-69120 Heidelberg, Germany.
[Gutschalk, Alexander; Oldermann, Konstanze] Univ Heidelberg, Dept Neuroradiol, D-69120 Heidelberg, Germany.
RP Gutschalk, A (reprint author), Univ Heidelberg, Dept Neurol, Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
EM Alexander_Gutschalk@med.uni-heidelberg.de
FU Deutsche Forschungsgemeinschaft (DFG) [GU 593/3-1]
FX The authors are grateful to Chris Micheyl for his helpful comments on a
previous version of this manuscript. This research was supported by
Deutsche Forschungsgemeinschaft (DFG Grant GU 593/3-1).
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NR 43
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 83
EP 92
DI 10.1016/j.heares.2009.08.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200009
PM 19699286
ER
PT J
AU Fallon, JB
Shepherd, RK
Brown, M
Irvine, DRF
AF Fallon, James B.
Shepherd, Robert K.
Brown, Mel
Irvine, Dexter R. F.
TI Effects of neonatal partial deafness and chronic intracochlear
electrical stimulation on auditory and electrical response
characteristics in primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Auditory cortex; Electrical stimulation; Neural
prosthesis; Sensorineural hearing loss
ID COCHLEAR HEARING-LOSS; ENHANCED FREQUENCY DISCRIMINATION; CAT INFERIOR
COLLICULUS; ADULT CATS; TEMPORAL RESOLUTION; NEURONAL RESPONSES;
PERCEPTUAL CONSEQUENCES; TONOTOPIC ORGANIZATION; CORTICAL PLASTICITY;
CONGENITAL DEAFNESS
AB The use of cochlear implants in patients with severe hearing losses but residual low-frequency hearing raises questions concerning the effects of chronic intracochlear electrical stimulation (ICES) on cortical responses to auditory and electrical stimuli. We investigated these questions by studying responses to tonal and electrical stimuli in primary auditory cortex (AI) of two groups of neonatally deafened cats with residual high-threshold, low-frequency hearing. One group were implanted with a multi-channel intracochlear electrode at 8 weeks of age, and received chronic ICES for up to 9 months before cortical recording. Cats in the other group were implanted immediately prior to cortical recording as adults. In all cats in both groups, multi-neuron responses throughout the rostro-caudal extent of AI had low characteristic frequencies (CFs), in the frequency range of the residual hearing, and high-thresholds. Threshold and minimum latency at CF did not differ between the groups, but in the chronic ICES animals there was a higher proportion of electrically but not acoustically excited recording sites. Electrical response thresholds were higher and latencies shorter in the chronically stimulated animals. Thus, chronic implantation and ICES affected the extent of AI that could be activated by acoustic stimuli and resulted in changes in electrical response characteristics. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Fallon, James B.; Shepherd, Robert K.; Irvine, Dexter R. F.] Bion Ear Inst, Melbourne, Vic, Australia.
[Fallon, James B.; Shepherd, Robert K.] Univ Melbourne, Dept Otolaryngol, Melbourne, Vic, Australia.
[Brown, Mel; Irvine, Dexter R. F.] Monash Univ, Sch Psychol Psychiat & Psychol Med, Fac Med Nursing & Hlth Sci, Clayton, Vic 3800, Australia.
RP Fallon, JB (reprint author), Bion Ear Inst, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM jfallon@bionicear.org
RI Irvine, Dexter/F-7474-2011; Fallon, James/B-5211-2012; Shepherd,
Robert/I-6276-2012; Fallon, James/B-6383-2014
FU NIDCD [N01-DC-3-1005, HHS-N-263-2007-00053-C]; Bionic Ear Institute
FX This work was funded by NIDCD (N01-DC-3-1005 and HHS-N-263-2007-00053-C)
and The Bionic Ear Institute. The Bionic Ear Institute acknowledges the
support it receives from the Victorian Government through its
Operational Infrastructure Support Program. The authors are grateful to
Jin Xu and Helen Feng for electrode manufacture and surgical assistance;
Anne Coco and Stephanie Epp for research assistance; Sue Pierce for
veterinary advice Elisa Borg for animal maintenance; Rodney Millard for
engineering support and helpful discussions on experimental design, and
Hugh McDermott, Peter Blarney and two anonymous reviewers for comments
on an earlier version of the manuscript.
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NR 61
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 93
EP 105
DI 10.1016/j.heares.2009.08.006
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200010
PM 19703532
ER
PT J
AU Paltoglou, AE
Sumner, CJ
Hall, DA
AF Paltoglou, Aspasia E.
Sumner, Christian J.
Hall, Deborah A.
TI Examining the role of frequency specificity in the enhancement and
suppression of human cortical activity by auditory selective attention
SO HEARING RESEARCH
LA English
DT Article
DE Attentional modulation; Frequency-dependent response region;
Task-related effects
ID RECEPTIVE-FIELD PLASTICITY; MACAQUE VISUAL-CORTEX; SINGLE-UNIT ACTIVITY;
STREAM SEGREGATION; FUNCTIONAL MRI; TASK-DIFFICULTY; TONOTOPIC
ORGANIZATION; IMAGE REGISTRATION; NEURAL MECHANISMS; FMRI ACTIVATION
AB This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. To test this prediction, low- and high-frequency sound sequences were interleaved to produce two concurrent auditory streams. Six normally hearing participants either performed a task which required them to attend to one or the other stream or listened passively to the sounds while functional images were acquired using a high-resolution (1.5 mm x 1.5 mm x 2.5 mm) sequence. Two statistical comparisons identified the attention-specific and general effects of enhancement. The first controlled for task-related processes, while the second did not. Results demonstrated frequency-specific, attention-specific enhancement in the response to the attended frequency, but no response suppression for the unattended frequency. Instead, a general effect of suppression was found in several posterior sites, possibly related to resting-state processes. Furthermore, there was widespread general enhancement across auditory cortex when performing the task compared to passive listening. This enhancement did include frequency-sensitive regions, but was not restricted to them. In conclusion, our results show partial support for frequency-specific enhancement. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Hall, Deborah A.] Nottingham Trent Univ, Div Psychol, Sch Social Sci, Nottingham NG1 4BU, England.
[Paltoglou, Aspasia E.; Sumner, Christian J.; Hall, Deborah A.] MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Hall, DA (reprint author), Nottingham Trent Univ, Div Psychol, Sch Social Sci, Burton St, Nottingham NG1 4BU, England.
EM aspa.paltoglou@abdn.ac.uk; chris@ihr.mrc.ac.uk; deborah.hall@ntu.ac.uk
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NR 70
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2009
VL 257
IS 1-2
BP 106
EP 118
DI 10.1016/j.heares.2009.08.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 511QB
UT WOS:000271180200011
PM 19706320
ER
PT J
AU Larsen, E
Liberman, MC
AF Larsen, Erik
Liberman, M. Charles
TI Slow build-up of cochlear suppression during sustained contralateral
noise: Central modulation of olivocochlear efferents?
SO HEARING RESEARCH
LA English
DT Article
DE Feedback; Inner ear; Brainstem plasticity; Olivocochlear reflex
ID EVOKED OTOACOUSTIC EMISSIONS; AUDITORY-NERVE FIBERS; INDUCED
HEARING-LOSS; OUTER HAIR-CELLS; ACOUSTIC INJURY; GUINEA-PIG;
ELECTRICAL-STIMULATION; CENTRIFUGAL PATHWAYS; LOUD-SOUND; REFLEX
AB The strength of the medial olivocochlear (OC) reflex is routinely assayed by measuring suppression of ipsilateral responses such as otoacoustic emissions (OAEs) by a brief contralateral noise, e.g., (Berlin, C.I., Hood, L.J., Cecola, P., Jackson, D.F., Szabo, P. 1993. Does type I afferent dysfunction reveal itself through lack of efferent suppression. Hear. Res. 65, 40-50). Here, we show in anesthetized guinea pigs, that the magnitude of OC-mediated suppression of ipsilateral cochlear responses (i.e., compound actions potentials (CAPs), distortion product (DP) OAEs and round-window noise) slowly builds over 2-3 min during a sustained contralateral noise. The magnitude of this build-up suppression was largest at low ipsilateral stimulus intensities, as seen for suppression measured at contra-noise onset. However, as a function of stimulus frequency, build-up suppression magnitude was complementary to onset suppression, i.e., largest at the lowest and highest frequencies tested. Both build-up and onset suppression were eliminated by cutting the OC bundle. In contrast to "slow effects" of shock-evoked medial OC activity (Sridhar, T.S., Liberman, M.C., Brown, M.C., Sewell, W.F. 1995. A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig. J. Neurosci. 15, 3667-3678), which are mediated by slow intracellular changes in Ca concentration in OHCs, build-up effects of contralateral noise are immediately extinguished upon OC bundle transection and are likely mediated by central modulation of the response rates in MOC fibers due to the sustained noise. Results suggest that conventional tests of OC reflex strength may underestimate its magnitude in noisy environments. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Larsen, Erik; Liberman, M. Charles] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Larsen, Erik; Liberman, M. Charles] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02139 USA.
[Liberman, M. Charles] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Liberman, MC (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM charles_liberman@meei.harvard.edu
FU NIDCD [R01 (DC00188), P30 (DC05209), T32 DC00038]
FX This work was supported by an R01 (DC00188) and a P30 (DC05209) from the
NIDCD. E. Larsen was partly supported by a training grant from the NIDCD
(T32 DC00038). This report is based on a thesis submitted in partial
fulfillment of the requirements for the degree of Doctor of Philosophy
in the Speech and Hearing Bioscience and Technology Program of the
Harvard-MIT Division of Health Sciences and Technology.
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NR 56
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2009.02.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000001
PM 19232534
ER
PT J
AU Osmanski, MS
Marvit, P
Depireux, DA
Dooling, RJ
AF Osmanski, Michael S.
Marvit, Peter
Depireux, Didier A.
Dooling, Robert J.
TI Discrimination of auditory gratings in birds
SO HEARING RESEARCH
LA English
DT Article
DE Auditory grating; Threshold; Budgerigar; Zebra finch; Human;
Psychoacoustics
ID BUDGERIGARS MELOPSITTACUS-UNDULATUS; ZEBRA FINCHES; PERCEPTUAL
ORGANIZATION; HARMONIC COMPLEXES; ACOUSTIC STIMULI; DYNAMIC SPECTRA;
UNIT RESPONSES; NATURAL SOUNDS; CONTACT CALLS; SPEECH
AB Auditory gratings (also called auditory ripples) are a family of complex, broadband sounds with sinusoidally modulated logarithmic amplitudes and a drifting spectral envelope. These stimuli have been studied both physiologically in mammals and psychophysically in humans. Auditory gratings share spectro-temporal properties with many natural sounds, including species-specific vocalizations and the formant transitions of human speech. We successfully trained zebra finches and budgerigars, using operant conditioning methods, to discriminate between flat-spectrum broadband noise and noises with ripple spectra of different densities that moved up or down in frequency at various rates. Results show that discrimination thresholds (minimum modulation depth) increased as a function of increasing grating periodicity and density across all species. Results also show that discrimination in the two species of birds was better at those grating periodicities and densities that are prominent in their species-specific vocalizations. Budgerigars were generally more sensitive than both zebra finches and humans. Both bird species showed greater sensitivity to descending auditory gratings, which mirrors the main direction in their vocalizations. Humans, on the other hand, showed no directional preference even though speech is somewhat downward directional. Overall, our results are suggestive of both common strategies in the processing of complex sounds between birds and mammals and specialized, species-specific variations on that processing in birds. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Osmanski, Michael S.; Marvit, Peter; Dooling, Robert J.] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Depireux, Didier A.] Univ Maryland, Dept Anat & Neurobiol, Baltimore, MD 21210 USA.
RP Marvit, P (reprint author), Univ Maryland, Dept Psychol, Biol Psychol Bldg, College Pk, MD 20742 USA.
EM michael.osmanski@gmail.com; pmarvit@gmail.com; depireux@gmail.com;
dooling@psyc.umd.edu
FU NIH/NIDCD [R01 DC000198]
FX This research was supported by NIH/NIDCD R01 DC000198. The authors thank
two anonymous reviewers for their helpful comments.
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NR 49
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 11
EP 20
DI 10.1016/j.heares.2009.04.020
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000002
PM 19427374
ER
PT J
AU Vetesnik, A
Turcanu, D
Dalhoff, E
Gummer, AW
AF Vetesnik, Ales
Turcanu, Diana
Dalhoff, Ernst
Gummer, Anthony W.
TI Extraction of sources of distortion product otoacoustic emissions by
onset-decomposition
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear amplifier; Hearing loss; Nonlinear mechanical distortion;
Coherent reflection; Estimated distortion product threshold; Adaptation
ID COCHLEAR HEARING-LOSS; DPOAE FINE-STRUCTURE; EFFERENT-MEDIATED
ADAPTATION; INPUT/OUTPUT FUNCTIONS; AUDITORY-SENSITIVITY; RAPID
ADAPTATION; BASILAR-MEMBRANE; FREQUENCY PLACE; GROWTH-BEHAVIOR;
GUINEA-PIG
AB The cubic component of the distortion product otoacoustic emission (DPOAE) in response to two tones of frequency f(1) and f(2) is generated by so-called primary- and secondary-source mechanisms in the cochlea. Interference between the resulting two source components can limit the usefulness of DPOAEs in assessing cochlear function. Although techniques are available for separating the source components, depending on the application, they can be either time-consuming or ineffective without a priori knowledge of optimal parameters. Here, we investigated, in humans, the possibility of separating the source components in the time-domain by sampling the onset and offset of the DPOAE-time signal at appropriate instants. Therefore, a DPOAE paradigm was developed in which the f(2) tone was periodically switched on during the continuous presence of the f(1) tone. F(2) was increased in 20-Hz steps from 1.5 to 2.5 kHz and the ratio f(2)/f(1) held constant at 1.2; measurements were made at six primary tone levels, ranging from L(2) = 25 to 65 dB SPL To investigate the possibility of separating the two sources by appropriate sampling, we developed an algorithm called onset-decomposition. The algorithm is based on the shape properties of DP-grams constructed from DPOAE responses at different time instants in the onset of the DPOAE signal. Thus, at each such time instant, the source components were extracted by time-windowing of the corresponding DP-gram. The time courses of the amplitude onsets of these separated primary- and secondary-source components provided evidence that the primary-source component attained its steady-state before the secondary-source component started to significantly influence the DPOAE by interference with the primary-source component. Consequently, in the final paradigm, the primary-source component is extracted by sampling the DPOAE signal at a single pre-defined time instant after the onset of the f(2) stimulus tone, before the secondary component begins to interfere. Based on the near-absence of interference maxima and minima in the DP-grams, the appropriate sampling instant was 8-10 ms for all frequencies and intensities in the stimulus set. Extracting the primary-source by onset sampling has the advantage that when individual source components for a given f2 are to be investigated, there is no need to measure a DP-gram. In conclusion, it is shown that the technique can reliably and quickly separate the source components, making it an attractive paradigm for applications in basic research and clinical diagnosis. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Turcanu, Diana; Dalhoff, Ernst; Gummer, Anthony W.] Univ Tubingen, Dept Otolaryngol, Sect Physiol Acoust & Commun, Tubingen, Germany.
[Vetesnik, Ales] Czech Tech Univ, Dept Nucl Chem, CR-16635 Prague, Czech Republic.
RP Gummer, AW (reprint author), Univ Tubingen, Dept Otolaryngol, Sect Physiol Acoust & Commun, Elfriede Aulhorn Str 5, Tubingen, Germany.
EM vetesnik@fjfi.cvut.cz; diana.turcanu@uni-tuebin-gen.de;
ernst.dalhoff@web.de; anthony.gummer@uni-tuebingen.de
FU Marie Curie Intra-European Fellowship EAR-POST [MEIF-CT-2003-502451];
German Research Council [DFG Gu 194/8-1]
FX Supported by the Marie Curie Intra-European Fellowship EAR-POST
(MEIF-CT-2003-502451) and by the German Research Council, DFG Gu
194/8-1. The authors are grateful to Prof. Renato Nobili for inducing
interest in f2 pulsed paradigms.
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NR 70
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 21
EP 38
DI 10.1016/j.heares.2009.06.002
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000003
PM 19523509
ER
PT J
AU Luddemann, H
Riedel, H
Kollmeier, B
AF Lueddemann, Helge
Riedel, Helmut
Kollmeier, Birger
TI Electrophysiological and psychophysical asymmetries in sensitivity to
interaural correlation steps
SO HEARING RESEARCH
LA English
DT Article
DE Binaural psychoacoustics; Spatial diffuseness; Scale transform; Late
auditory evoked potentials; Sustained potential; Auditory scene analysis
ID AUDITORY BRAIN-STEM; EVOKED-POTENTIALS; CORRELATION DISCRIMINATION;
BINAURAL DETECTION; CROSS-CORRELATION; SPEECH-INTELLIGIBILITY; INFERIOR
COLLICULUS; SOURCE LOCALIZATION; MISMATCH RESPONSE; AURAL CORRELATION
AB The binaural auditory system's sensitivity to changes in the interaural cross correlation (IAC), as an indicator for the perceived spatial diffuseness of a sound, is of major importance for the ability to distinguish concurrent sound sources. In this article, we present electroencephalographical and corresponding psychophysical experiments with stepwise transitions of the IAC in continuously running noise.
Both the transient and sustained brain response, display electrophysiological correlates of specific binaural processing in humans. The transient late auditory evoked potentials (LAEP) systematically depend on the size of the IAC transition, the reference correlation preceding the transition, the direction of the transition and on unspecific context information from the stimulus sequence.
The psychophysical and electrophysiological data are characterized by two asymmetries. (1) Major asymmetry: for reference correlations of +1 and -1, psychoacoustical thresholds are comparatively lower, and the peak-to-peak-amplitudes of LAEP are larger than for a reference correlation of zero. (2) Minor asymmetry: for IAC transitions in the positive parameter range, perceptual thresholds are slightly better and peak-to-peak amplitudes are larger than in the negative range.
In all experimental conditions, LAEP amplitudes are linearly related to the dB scaled power ratio of correlated (N(0)) versus anticorrelated (N(pi)) signal components. The voltage gain of LAEP per dB(N(0)/N(pi)) closely corresponds to a constant perceptual distance between two correlations. We therefore suggest that activity in the auditory cortex and perceptual IAC sensitivity are better represented by the dB-scaled N(0)/N(pi) power ratio than by the normalized IAC itself (C) 2009 Elsevier B.V. All rights reserved.
C1 [Lueddemann, Helge; Riedel, Helmut; Kollmeier, Birger] Carl VonOssietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
RP Luddemann, H (reprint author), Carl VonOssietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
EM h.lueddemann@uni-oldenburg.de
FU Deutsche Forschungsgemeinschaft (DFG) [KO 942/19-1]
FX This work was supported by the Deutsche Forschungsgemeinschaft (DFG,
Project KO 942/19-1). The authors would like to thank Anita Gorges and
Frank Grunau for technical assistance and Steve Colburn and several
anonymous reviewers for their comments on previous versions of the
manuscript.
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NR 62
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 39
EP 57
DI 10.1016/j.heares.2009.06.010
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000004
PM 19555753
ER
PT J
AU Strimbu, CE
Ramunno-Johnson, D
Fredrickson, L
Arisaka, K
Bozovic, D
AF Strimbu, C. E.
Ramunno-Johnson, D.
Fredrickson, L.
Arisaka, K.
Bozovic, D.
TI Correlated movement of hair bundles coupled to the otolithic membrane in
the bullfrog sacculus
SO HEARING RESEARCH
LA English
DT Article
DE Auditory systems; Vestibular system; Hair cells; Otolithic membrane;
Bullfrog sacculus; High-speed imaging
ID MECHANOELECTRICAL TRANSDUCTION; SPONTANEOUS OSCILLATIONS; INTERNAL EAR;
CELLS; MECHANOTRANSDUCTION; STIFFNESS; AMPLIFICATION; STEREOCILIA;
MOTILITY; CHANNELS
AB High-speed imaging with a CMOS camera was used to track the motion of multiple hair bundles of the bullfrog sacculus. To maintain the natural degree of intercell coupling, the overlying otolithic membrane was left intact atop the in vitro preparation. Effects of an incoming mechanical signal were mimicked by laterally deflecting the membrane with a glass probe at physiological amplitudes. The motion evoked in the underlying hair bundles was found to be highly phase-locked, yielding an entrained response across hundreds of cells. We imaged significant portions of the saccular epithelium, up to 40 x 350 mu m(2), and observed a high degree of correlation over those scales. Published by Elsevier B.V.
C1 [Bozovic, D.] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA.
Calif NanoSyst Inst, Los Angeles, CA 90095 USA.
RP Bozovic, D (reprint author), Univ Calif Los Angeles, Dept Phys & Astron, 475 Portola Plaza, Los Angeles, CA 90095 USA.
EM strimbu@physics.ucla.edu; dameinrj@physics.ucla.edu;
lea@physics.ucla.edu; arisaka@physics.ucla.edu; bozovic@physics.ucla.edu
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NR 28
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 58
EP 63
DI 10.1016/j.heares.2009.06.015
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000005
PM 19573584
ER
PT J
AU Ng, CW
Plakke, B
Poremba, A
AF Ng, Chi-Wing
Plakke, Bethany
Poremba, Amy
TI Primate auditory recognition memory performance varies with sound type
SO HEARING RESEARCH
LA English
DT Article
DE Macaca mulatta; Delayed matching-to-sample; Vocalizations; Performance;
Same; Different; Rhesus; Monkey
ID VENTROLATERAL PREFRONTAL CORTEX; OBJECT LOCATION MEMORY; MONKEYS
CEBUS-APELLA; SEX-DIFFERENCES; RHESUS-MONKEYS; MACACA-MULATTA;
COMMUNICATION SOUNDS; GENDER-DIFFERENCES; TEMPORAL CORTEX;
AIR-CONDUCTION
AB Neural correlates of auditory processing, including for species-specific vocalizations that convey biological and ethological significance (e.g., social status, kinship, environment), have been identified in a wide variety of areas including the temporal and frontal cortices. However, few studies elucidate how non-human primates interact with these vocalization signals when they are challenged by tasks requiring auditory discrimination, recognition and/or memory. The present study employs a delayed matching-to-sample task with auditory stimuli to examine auditory memory performance of rhesus macaques (Macaca mulatto), wherein two sounds are determined to be the same or different. Rhesus macaques seem to have relatively poor short-term memory with auditory stimuli, and we examine if particular sound types are more favorable for memory performance. Experiment 1 suggests memory performance with vocalization sound types (particularly monkey), are significantly better than when using non-vocalization sound types, and male monkeys outperform female monkeys overall. Experiment 2, controlling for number of sound exemplars and presentation pairings across types, replicates Experiment 1, demonstrating better performance or decreased response latencies, depending on trial type, to species-specific monkey vocalizations. The findings cannot be explained by acoustic differences between monkey vocalizations and the other sound types, suggesting the biological, and/or ethological meaning of these sounds are more effective for auditory memory. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ng, Chi-Wing; Plakke, Bethany; Poremba, Amy] Univ Iowa, Dept Psychol, Behav & Cognit Neurosci Program, Iowa City, IA 52242 USA.
RP Poremba, A (reprint author), Univ Iowa, Dept Psychol, Behav & Cognit Neurosci Program, E11 Seashore Hall, Iowa City, IA 52242 USA.
EM amy-poremba@uiowa.edu
FU Amy Poremba from University; NIH, NIDCD [DC0007156]
FX We thank Dr. Mortimer Mishkin for his invaluable support of our
research, Dr. Yale Cohen for providing guidance and MATLAB scripts for
acoustic analyses, and Dr. Robert McMurray for advising on methods of
statistical analysis. This work was supported by funding awarded to Amy
Poremba from University of Iowa Startup Funds and NIH, NIDCD, DC0007156.
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NR 75
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 64
EP 74
DI 10.1016/j.heares.2009.06.014
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000006
PM 19567264
ER
PT J
AU Luo, X
Fu, QJ
Wu, HP
Hsu, CJ
AF Luo, Xin
Fu, Qian-Jie
Wu, Hung-Pin
Hsu, Chuan-Jen
TI Concurrent-vowel and tone recognition by Mandarin-speaking cochlear
implant users
SO HEARING RESEARCH
LA English
DT Article
DE Concurrent-vowel recognition; Concurrent-tone recognition; Cochlear
implants; Mandarin Chinese
ID SPEECH RECOGNITION; DEAF-CHILDREN; PERCEPTUAL SEGREGATION;
FREQUENCY-MODULATION; TEMPORAL CUES; HEARING; PITCH; AGE; NOISE
AB In Mandarin Chinese, tonal patterns are lexically meaningful. In a multi-talker environment, competing tones may create interference in addition to competing vowels and consonants. The present study measured Mandarin-speaking cochlear implant (CI) users' ability to recognize concurrent vowels, tones, and syllables in a concurrent-syllable recognition test. Concurrent syllables were constructed by summing either one Chinese syllable each from one male and one female talker or two syllables from the same male talker. Each talker produced 16 different syllables (4 vowels combined with 4 tones); all syllables were normalized to have the same overall duration and amplitude. Both single- and concurrent-syllable recognition were measured in 4 adolescent and 4 adult Cl subjects, using their clinically assigned speech processors. The results showed no significant difference in performance between the adolescent and adult CI subjects. With single syllables, mean vowel recognition was 90% correct, while tone and syllable recognition were only 63% and 57% correct, respectively. With concurrent syllables, vowel, tone, and syllable recognition scores dropped by 40-60 percentage points. Concurrent-syllable performance was significantly correlated with single-syllable performance. Concurrent-vowel and syllable recognition were not significantly different between the same- and different-talker conditions, while concurrent-tone recognition was significantly better with the same-talker condition. Vowel and tone recognition were better when concurrent syllables contained the same vowels or tones, respectively. Across the different vowel pairs, tone recognition was less variable than vowel recognition; across the different tone pairs, vowel recognition was less variable than tone recognition. The present results suggest that interference between concurrent tones may contribute to Mandarin-speaking Cl users' susceptibility to competing-talker backgrounds. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Luo, Xin] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA.
[Fu, Qian-Jie] House Ear Res Inst, Div Commun & Auditory Neurosci, Los Angeles, CA 90057 USA.
[Wu, Hung-Pin] Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan.
[Wu, Hung-Pin] Buddhist Tzuchi Gen Hosp, Dept Otolaryngol, Taipei, Taiwan.
[Hsu, Chuan-Jen] Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan.
[Hsu, Chuan-Jen] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan.
RP Luo, X (reprint author), Purdue Univ, Dept Speech Language & Hearing Sci, 500 Oval Dr, W Lafayette, IN 47907 USA.
EM luo5@purdue.edu
FU NIH [R03-DC-008192, R01-DC-004993]
FX We are grateful to all subjects for their participation in the present
study. We thank John J. Galvin III for assistance in editing the
manuscript. We would also like to thank two anonymous reviewers for
their constructive comments on an earlier version of this paper.
Research was supported in part by NIH Grants R03-DC-008192 and
R01-DC-004993.
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NR 32
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 75
EP 84
DI 10.1016/j.heares.2009.07.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000007
PM 19595753
ER
PT J
AU Mulders, WHAM
Paolini, AG
Needham, K
Robertson, D
AF Mulders, W. H. A. M.
Paolini, A. G.
Needham, K.
Robertson, D.
TI Synaptic responses in cochlear nucleus neurons evoked by activation of
the olivocochlear system
SO HEARING RESEARCH
LA English
DT Article
DE Efferents; Hearing; Guinea pigs; Intracellular recording
ID ELECTRICAL-STIMULATION PARAMETERS; ONSET CHOPPER NEURONS; INTRACELLULAR
RESPONSES; COMMISSURAL NEURONS; STELLATE CELLS; GUINEA-PIG;
CONTRALATERAL SOUND; RAT; INHIBITION; DEPENDENCE
AB The action of olivocochlear collaterals to the cochlear nucleus is not fully established. Synaptic ultrastructure suggests an excitatory role. Extracellular recordings show spikes evoked by electrical stimulation of olivocochlear axons, but these spikes in the cochlear nucleus may be antidromic (activation of output axons) or orthodromic (synaptic input). We therefore recorded intracellular responses to shocks to olivocochlear axons in anaesthetized guinea pigs. In chopper and primary-like neurons shocks caused either no response or an inhibitory synaptic response (IPSP), but never an excitatory one (EPSP). In contrast, onset neurons never showed IPSPs but showed a variety of other responses; antidromic spikes, EPSPs, orthodromic spikes or no effect. The results agree with earlier extracellular observations in that olivocochlear collaterals provide excitatory input to onset neurons. Because some onset neurons are inhibitory they may be the source of the IPSPs observed in other cochlear nucleus neurons. The data also show that electrical stimulation at the floor of the IVth ventricle results in antidromic spikes as well. However, intracellular recording enabled the orthodromic action to be verified and the presumed olivocochlear action to be better understood. Our data support the hypothesis that olivocochlear collaterals initiate excitatory input onto onset-chopper neurons. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Mulders, W. H. A. M.; Robertson, D.] Univ Western Australia, Auditory Lab, Discipline Physiol, Sch Biomed Biomol & Chem Sci, Crawley, WA 6009, Australia.
[Needham, K.] Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
[Paolini, A. G.] La Trobe Univ, Sch Psychol Sci, Graeme Clark Ctr, Bundoora, Vic 3086, Australia.
RP Mulders, WHAM (reprint author), Univ Western Australia, Auditory Lab, Discipline Physiol, Sch Biomed Biomol & Chem Sci M311, 35 Stirling Highway, Crawley, WA 6009, Australia.
EM hmulders@cyllene.uwa.edu.au
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NR 43
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 85
EP 92
DI 10.1016/j.heares.2009.07.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000008
PM 19607895
ER
PT J
AU Bal, R
Baydas, G
Naziroglu, M
AF Bal, Ramazan
Baydas, Giyasettin
Naziroglu, Mustafa
TI Electrophysiological properties of ventral cochlear nucleus neurons of
the dog
SO HEARING RESEARCH
LA English
DT Article
DE Auditory pathways; Ventral cochlear nucleus; Patch-clamp; Dog
ID AUDITORY-NERVE FIBERS; VOLTAGE-SENSITIVE CONDUCTANCES; OCTOPUS CELLS;
HORSERADISH-PEROXIDASE; BUSHY CELLS; LATERAL LEMNISCUS; CHOLINERGIC
MODULATION; SUBESOPHAGEAL GANGLIA; ELECTRICAL-PROPERTIES;
POSTNATAL-DEVELOPMENT
AB Neurons in the cochlear nucleus (CN) have distinct anatomical and biophysical specializations and extract various facets of auditory information which are transmitted to the higher auditory centres. The aim of the present study was to determine if the principal neurons (stellate, bushy and octopus cells) of the ventral cochlear nucleus (VCN) in 2-week-old dog brain slices share common electrophysiological properties with the principal neurons of mouse VCN. Stellate cells (n = 21, of which three were anatomically identified), fired large, regular trains of action potentials in response to depolarizing current pulses. Input resistance and membrane time constant were 176 +/- 35.9 M Omega (n = 21) and 8.8 +/- 1.4 ms (n = 21), respectively. Bushy cells, (n = 6, of which three were anatomically identified) responded with a single action potential at the onset of depolarizing current steps and showed large hyperpolarizing voltage changes that sag back toward rest to hyperpolarizing current pulses. Input resistance and membrane time constant were 120.4 +/- 56.1 M Omega (n = 5) and 7.6 +/- 2.3 ms (n = 5), respectively. Octopus cells (n = 17, of which seven were anatomically identified) fired a single action potential at the start of a depolarizing current step and exhibited a pronounced depolarizing sag of the membrane potential towards the resting value to hyperpolarizing current steps. Input resistance and membrane time constant were 17.58 +/- 1.3 M Omega (n = 15) and 1.34 +/- 0.13 ms (n = 15), respectively. While stellate cells did not have a threshold rate of depolarization (dV/dt(thresh)), bushy and octopus had a dV/dt(thresh) of 5.06 +/- 1.04 mV/ms (n = 4) and 10.6 +/- 2.0 mV/ms (n = 6), respectively. In octopus cells, the single action potential was abolished by tetrodotoxin (TTX). An alpha-dendrotoxin (alpha-DTX)-sensitive, low-voltage-activated potassium conductance (g(KL)) together with a ZD7288-sensitive, mixed-cation conductance (g(b)) were responsible for the low input resistance, and as a consequence for the brief time constant of the octopus cells. We conclude that the principal neurons of the dog VCN are, as in mouse and cat, distinguishable on the basis of whole-cell patch-clamp recordings. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bal, Ramazan] Firat Univ, Fac Med, Dept Biophys, TR-23119 Elazig, Turkey.
[Baydas, Giyasettin] Bingol Univ, Bingol Univ Rectorate, Bingol, Turkey.
[Naziroglu, Mustafa] Suleyman Demirel Univ, Fac Med, Dept Biophys, TR-32200 Isparta, Turkey.
RP Bal, R (reprint author), Firat Univ, Fac Med, Dept Biophys, TR-23119 Elazig, Turkey.
EM rbal1969@gmail.com
FU TUBITAK [105 O 215]
FX We are grateful to Prof. Donata Oertel for her guidance and support in
setting up the electrophysiology lab. We thank Dr. Adrian Rees for
reading the manuscript and making suggestions for its improvement. This
work was supported by a grant from TUBITAK, 105 O 215 (Turkey).
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NR 76
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 93
EP 103
DI 10.1016/j.heares.2009.07.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000009
PM 19615433
ER
PT J
AU Finlayson, PG
Kaltenbach, JA
AF Finlayson, Paul G.
Kaltenbach, James A.
TI Alterations in the spontaneous discharge patterns of single units in the
dorsal cochlear nucleus following intense sound exposure
SO HEARING RESEARCH
LA English
DT Article
DE Burst; Tinnitus; Spike waveform; Couplet; Fusiform cells; Dorsal
cochlear nucleus
ID SPONTANEOUS NEURAL ACTIVITY; STEM AUDITORY NUCLEI; AUTOTOMY-INDUCED
CHANGES; COMPLEX-SPIKING NEURONS; ROOT GANGLION NEURONS; INDUCED
HEARING-LOSS; BRAIN-STEM; GUINEA-PIG; INFERIOR COLLICULUS; NEUROPATHIC
PAIN
AB Electrophysiological recordings in the dorsal cochlear nucleus (DCN) were conducted to determine the nature of changes in single unit activity following intense sound exposure and how they relate to changes in multiunit activity. Single and multiunit spontaneous discharge rates and auditory response properties were recorded from the left DCN of tone exposed and control hamsters. The exposure condition consisted of a 10 kHz tone presented in the free-field at a level of 115 dB for 4 h. Recordings conducted at 5-6 days post-exposure revealed several important changes. Increases in multiunit spontaneous neural activity were observed at surface and subsurface levels of the DCN of exposed animals, reaching a peak at intermediate depths corresponding to the fusiform cell layer and upper level of the deep layer. Extracellular spikes from single units in the DCN of both control and exposed animals characteristically displayed either M- or W-shaped waveforms, although the proportion of units with M-shaped spikes was higher in exposed animals than in controls. W-shaped spikes showed significant increases in the duration of their major peaks after exposure, suggestive of changes in the intrinsic membrane properties of neurons. Spike amplitudes were not found to be significantly increased in exposed animals. Spontaneous discharge rates of single units increased significantly from 8.7 spikes/s in controls to 15.9 spikes/s after exposure. Units with the highest activity in exposed animals displayed type III electrophysiological responses patterns, properties usually attributed to fusiform cells. Increases in spontaneous discharge rate were significantly larger when the comparison was limited to a subset of units having type III frequency response patterns. There was an increase in the incidence of simple spiking activity as well as in the incidence of spontaneous bursting activity, although the incidence of spikes occurring in bursts was low in both animal groups (i.e., <30%). Despite this low incidence, approximately half of the increase in spontaneous activity in exposed animals was accounted for by an increase in bursting activity. Finally, we found no evidence of an increase in the mean number of spontaneously active units in electrode penetrations of exposed animals compared to those in controls. Overall our results indicate that the increase in multiunit activity observed at the DCN surface reflects primarily an increase in the spontaneous discharge rates of single units below the DCN surface, of which approximately half was contributed by spikes in bursts. The highest level of hyperactivity was observed among units having the response properties most commonly attributed to fusiform cells. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Finlayson, Paul G.] Wayne State Univ, Sch Med, Dept Otolaryngol, Detroit, MI 48201 USA.
[Kaltenbach, James A.] Cleveland Clin, Dept Neurosci, Head & Neck Inst, Cleveland, OH 44195 USA.
RP Finlayson, PG (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol, 5E UHC, Detroit, MI 48201 USA.
EM pfinlays@med.wayne.edu
FU NIDCD [R01 DC03258]
FX This project was supported by a Grant from NIDCD (R01 DC03258).
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NR 76
TC 46
Z9 47
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 104
EP 117
DI 10.1016/j.heares.2009.07.006
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000010
PM 19622390
ER
PT J
AU Shechter, B
Dobbins, HD
Marvit, P
Depireux, DA
AF Shechter, B.
Dobbins, H. D.
Marvit, P.
Depireux, D. A.
TI Dynamics of spectro-temporal tuning in primary auditory cortex of the
awake ferret
SO HEARING RESEARCH
LA English
DT Article
DE Tuning dynamics; Auditory cortex; AI; Temporal symmetry; Inferior
colliculus; IC; Auditory grating; Spectro-temporal receptive field; STRF
ID LATERAL GENICULATE-NUCLEUS; RECEPTIVE-FIELD PROPERTIES; INPUT X-CELLS;
UNIT RESPONSES; REVERSE CORRELATION; NATURAL STIMULI; CAT; NEURONS;
SYSTEM; CLASSIFICATION
AB We previously characterized the steady-state spectro-temporal tuning properties of cortical cells with respect to broadband sounds by using sounds with sinusoidal spectro-temporal modulation envelope where spectral density and temporal periodicity were constant over several seconds. However, since speech and other natural sounds have spectro-temporal features that change substantially over milliseconds, we study the dynamics of tuning by using stimuli of constant overall intensity, but alternating between a flat spectro-temporal envelope and a modulated envelope with well defined spectral density and temporal periodicity. This allows us to define the tuning of cortical cells to speech-like and other rapid transitions, on the order of milliseconds, as well as the time evolution of this tuning in response to the appearance of new features in a sound. Responses of 92 cells in AI were analyzed based on the temporal evolution of the following measures of tuning after a rapid transition in the stimulus: center of mass and breadth of tuning; separability and direction selectivity; temporal and spectral asymmetry. We find that tuning center of mass increased in 70% of cells for spectral density and in 68% of cells for temporal periodicity, while roughly half of cells (47%) broadened their tuning, with the other half (53%) sharpening tuning. The majority of cells (73%) were initially not direction selective, as measured by an inseparability index, which had an initial low value that then increased to a higher steady state value. Most cells were characterized by temporal symmetry, while spectral symmetry was initially high and then progressed to low steady-state values (61%). We demonstrate that cortical neurons can be characterized by a lag-dependent modulation transfer function. This characterization, when measured through to steady-state, becomes equivalent to the classical spectro-temporal receptive field. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Depireux, D. A.] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA.
[Shechter, B.; Dobbins, H. D.; Depireux, D. A.] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA.
[Shechter, B.] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Dobbins, H. D.; Depireux, D. A.] Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA.
[Marvit, P.] Univ Maryland, Dept Psychol, Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
RP Depireux, DA (reprint author), Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA.
EM barak.shechter@gmail.com; depireux@gmail.com
FU NIH/NIDCD [1 RO01 DC005937]; NIH/NINDS [2T32NS007375-11]
FX We thank Yadong "KK" Ji for extensive help in animal care and data
acquisition, and Sridhar Kalluri and Asaf Keller for help in preparation
of this manuscript. This research was funded by NIH/NIDCD 1 RO01
DC005937 awarded to DAD. PM also received support from training grant
NIH/NINDS 2T32NS007375-11.
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NR 34
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2009
VL 256
IS 1-2
BP 118
EP 130
DI 10.1016/j.heares.2009.07.005
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 502XV
UT WOS:000270495000011
PM 19619629
ER
PT J
AU Ries, DT
DiGiovanni, JJ
AF Ries, Dennis T.
DiGiovanni, Jeffrey J.
TI Effects of recurrent tonal information on auditory working memory for
pitch
SO HEARING RESEARCH
LA English
DT Article
DE Frequency; Pitch; Difference limen; Auditory working memory
ID TERM RECOGNITION MEMORY; UP-DOWN METHOD; ABSOLUTE PITCH; RETROACTIVE
INTERFERENCE; TONES; REPETITION; STAIRCASE; STANDARD; LOUDNESS; INPUT
AB This study ascertained the influence of repeating pitch information within an intervening tonal sequence upon the extent of interference for a pitch standard held within auditory working memory as measured by the difference limen for frequency (DLF). Standard and comparison tones were presented to subjects and same/different responses were obtained using a touch screen monitor and the DLF was measured using single interval adjustment matrix (SIAM) procedure [Kaernbach, C., 1990. A single-interval adjustment-matrix (SIAM) procedure for unbiased adaptive testing. J. Acoust. Soc. Am. 88, 2645-2655]. Estimates of the DLF were obtained in a control condition with a silent inter-comparison interval and three conditions containing intervening tones within the temporal gap between the standard and comparison stimuli. The presence of intervening stimuli produced a significant increase in the DLF when the intervening tonal sequence contained tones with pitches that differed from that of the standard (Int condition) as well as when the sequence contained a tone with a pitch identical to that of the comparison (RptCmp condition). Further, the DLFs obtained for RptCmp condition were significantly higher than those measured in the Int condition. The DLFs measured in the condition where the pitch of an intervening tone was identical to the standard were significantly lower than those for the Int and RptCmp condition, but did not differ from the DLFs for the control condition. These results indicate that either a release from or an increase in interference in auditory working memory for pitch can occur dependent upon the frequency relationships between of the standard, comparison, and intervening tones. (C) 2009 Elsevier B.V. All rights reserved.
C1 [DiGiovanni, Jeffrey J.] Ohio Univ, Sch Hearing Speech & Language Sci, Auditory Psychophys & Signal Proc Lab, Athens, OH 45701 USA.
[Ries, Dennis T.] Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W241, Auditory Percept Lab, Athens, OH 45701 USA.
RP Ries, DT (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W221, Athens, OH 45701 USA.
EM ries@ohio.edu; digiovan@ohio.edu
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NR 43
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 14
EP 21
DI 10.1016/j.heares.2009.05.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600002
PM 19435599
ER
PT J
AU Haake, SM
Dinh, CT
Chen, SB
Eshraghi, AA
Van De Water, TR
AF Haake, Scott M.
Dinh, Christine T.
Chen, Shibing
Eshraghi, Adrien A.
Van De Water, Thomas R.
TI Dexamethasone protects auditory hair cells against TNF alpha-initiated
apoptosis via activation of PI3K/Akt and NF kappa B signaling
SO HEARING RESEARCH
LA English
DT Article
DE Organ of Corti explants; Tumor necrosis factor alpha; Apoptosis;
Auditory hair cells; Dexamethasone; Nuclear factor kappa B;
Otoprotection
ID SPIRAL LIGAMENT FIBROCYTES; NECROSIS-FACTOR-ALPHA; INDUCED HEARING-LOSS;
GLUCOCORTICOID-RECEPTOR ANTAGONIST; GUINEA-PIG COCHLEA; PROINFLAMMATORY
CYTOKINES; ACOUSTIC TRAUMA; PHOSPHOLIPASE-A2 INHIBITOR; CONSERVES
HEARING; MOUSE COCHLEA
AB Background: Tumor necrosis factor alpha (TNF alpha) is associated with trauma-induced hearing loss. Local treatment of cochleae of trauma-exposed animals with a glucocorticoid is effective in reducing the level of hearing loss that occurs post-trauma (e.g., electrode insertion trauma-induced hearing loss/dexamethasone treatment).
Hypothesis: Dexamethasone (Dex) protects auditory hair cells (AHCs) from trauma-induced loss by activating cellular signal pathways that promote cell survival.
Materials and methods: Organ of Corti explants challenged with an ototoxic level of TNF alpha was the trauma model with Dex the otoprotective drug. A series of inhibitors were used in combination with the Dex treatment of TNF alpha-exposed explants to investigate the signal molecules that participate in Dex-mediated otoprotection. The otoprotective capacity of Dex against TNF alpha ototoxicity was determined by hair cell counts obtained from fixed explants stained with FITC-phalloidin labeling with investigators blinded to specimen identity.
Results: The general caspase inhibitor Boc-d-fmk prevented TNF alpha-induced AHC death. There was a significant reduction (p < 0.05) in the efficacy of Dex otoprotection against TNF alpha ototoxicity when the following cellular events were blocked: (1) glucocorticoid receptors (Mif); (2) PI3K (LY294002); (3) Akt/PKB (SH-6); and (4) NF kappa B (NF kappa B-I).
Conclusion: Dex treatment protects hair cells against TNF alpha apoptosis in vitro by activation of PI3K/Akt and NF kappa B signaling. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Haake, Scott M.; Dinh, Christine T.; Chen, Shibing; Eshraghi, Adrien A.; Van De Water, Thomas R.] Univ Miami, Miller Sch Med, Dept Otolaryngol, Cochlear Implant Res Program,Ear Inst, Miami, FL 33136 USA.
RP Van De Water, TR (reprint author), Univ Miami, Miller Sch Med, Dept Otolaryngol, Cochlear Implant Res Program,Ear Inst, 1600 NW 10th Ave,RMSB 3160, Miami, FL 33136 USA.
EM shaake@med.miami.edu; ctdinh@gmail.com; s.chen4@miami.edu;
aeshraghi@med.miami.edu; tvandewater@med.miami.edu
FU Advanced Bionics Corporation, Valencia CA
FX Supported by a grant from Advanced Bionics Corporation, Valencia CA to
T.R.V.
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NR 58
TC 36
Z9 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 22
EP 32
DI 10.1016/j.heares.2009.05.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600003
PM 19442713
ER
PT J
AU Kraus, KS
Ding, D
Zhou, Y
Salvi, RJ
AF Kraus, K. S.
Ding, D.
Zhou, Y.
Salvi, R. J.
TI Central auditory plasticity after carboplatin-induced unilateral inner
ear damage in the chinchilla: Up-regulation of GAP-43 in the ventral
cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE Carboplatin; GAP-43; Ventral cochlear nucleus; Chinchilla; Hair cells
ID HAIR CELL LOSS; CHOLINE-ACETYLTRANSFERASE ACTIVITY; PERIPHERAL-NERVE
INJURY; RETINAL GANGLION-CELLS; IN-SITU HYBRIDIZATION; MESSENGER-RNA;
BRAIN-STEM; OTOACOUSTIC EMISSIONS; NEURITE OUTGROWTH; AXON REGENERATION
AB Inner ear damage may lead to structural changes in the central auditory system. In rat and chinchilla, cochlear ablation and noise trauma result in fiber growth and synaptogenesis in the ventral cochlear nucleus (VCN). In this study, we documented the relationship between carboplatin-induced hair cell degeneration and VCN plasticity in the chinchilla. Unilateral application of carboplatin (5 mg/ml) on the round window membrane resulted in massive hair cell loss. Outer hair cell degeneration showed a pronounced basal-to-apical gradient while inner hair cell loss was more equally distributed throughout the cochlea. Expression of the growth associated protein GAP-43, a well-established marker for synaptic plasticity, was up-regulated in the ipsilateral VCN at 15 and 31 days post-carboplatin, but not at 3 and 7 days. In contrast, the dorsal cochlear nucleus showed only little change. In VCN, the high-frequency area dorsally showed slightly yet significantly stronger GAP-43 up-regulation than the low-frequency area ventrally, possibly reflecting the high-to-low frequency gradient of hair cell degeneration. Synaptic modification or formation of new synapses may be a homeostatic process to re-adjust mismatched inputs from two ears. Alternatively, massive fiber growth may represent a deleterious process causing central hyperactivity that leads to loudness recruitment or tinnitus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Kraus, K. S.; Ding, D.; Zhou, Y.; Salvi, R. J.] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Kraus, KS (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM skkraus@buffalo.edu; dding@buffalo.edu; ydzhou111@l63.com;
salvi@buffalo.edu
FU NIH [R01 DC06630]; NOHR [1068911]
FX Supported in part by NIH Grant R01 DC06630 and NOHR Grant 1068911.
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NR 60
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 33
EP 43
DI 10.1016/j.heares.2009.05.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600004
PM 19435600
ER
PT J
AU Navawongse, R
Voigt, HF
AF Navawongse, Rapeechai
Voigt, Herbert F.
TI Single neuron recordings in dorsal cochlear nucleus (DCN) of awake
gerbil
SO HEARING RESEARCH
LA English
DT Article
DE Dorsal cochlear nucleus; Electrophysiology; Awake recording; Gerbil;
Response map; Notch noise
ID UNANESTHETIZED DECEREBRATE GERBIL; ACOUSTIC STARTLE REFLEX;
AUDITORY-NERVE FIBERS; BRAIN-STEM NUCLEI; GUINEA-PIG; RESPONSE
PROPERTIES; MONGOLIAN GERBIL; DESCENDING PROJECTIONS; SOUND
LOCALIZATION; CARTWHEEL CELLS
AB The auditory responses of neurons in the dorsal cochlear nucleus (DCN) are known to be sensitive to anesthesia, and consequently many studies have used an unanesthetized, decerebrate preparation. Decerebration, however, severs multiple descending pathways to the DCN and is traumatic to the brain, and so sensory responses may be influenced. It was possible, by combining sterile surgery, animal conditioning, and mild restraint to allow recordings in awake gerbils (Merionus unguiculatus). Response maps (RMs), post-stimulus time histograms (PSTHs), and responses to notch noise stimuli were recorded in awake gerbils. Some units' responses were compared to those from previous experiments in anesthetized and decerebrate gerbil preparations. All RM types observed in decerebrate gerbils were also observed in the awake gerbil, with the notable exception of type IV units. Type III units were still the most commonly recorded units. No significant changes were observed in either RM shape or notch noise responses. Although most awake DCN units had spontaneous activity (typically <20 spikes/s), these rates were lower than those in decerebrate gerbils. Type III units' spontaneous activity rates were significantly different from those in the decerebrate prep (P < 0.05). DCN neurons may be more inhibited in awake gerbils. Although type III units were most sensitive to spectral notches, different unit types seem to respond slightly differently to notch noise. This study indicates that responses of DCN units in awake and decerebrate gerbils are different, though the shapes of RMs are the same. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Voigt, Herbert F.] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
Boston Univ, Hearing Res Ctr, Boston, MA 02215 USA.
RP Voigt, HF (reprint author), Boston Univ, Dept Biomed Engn, 44 Cummington St,Room 414C, Boston, MA 02215 USA.
EM navawong@bu.edu; hfv@bu.edu
FU National Institutes of Health [R01 DC001099]; Biomedical Engineering
department at Boston University; Hearing Research Center
FX This work was supported by Grant R01 DC001099 from the National
Institutes of Health, the Biomedical Engineering department at Boston
University, and the Hearing Research Center. The authors thank Dr. Kevin
Davis for access to his thesis data from decerebrate gerbils and Dr.
Kamal Sen for reading a previous version of this manuscript. This work
is a part of a doctoral dissertation in Biomedical Engineering submitted
by R. Navawongse.
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NR 84
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 44
EP 57
DI 10.1016/j.heares.2009.05.004
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600005
PM 19450672
ER
PT J
AU Manley, GA
AF Manley, Geoffrey A.
TI Spontaneous otoacoustic emissions in lizards: A comparison of the
skink-like lizard families Cordylidae and Gerrhosauridae
SO HEARING RESEARCH
LA English
DT Article
DE Lizard hearing; Spontaneous otoacoustic emissions; Evolution
ID SCANNING ELECTRON-MICROSCOPE; FROG RANA-ESCULENTA; BOBTAIL LIZARD;
TEMPERATURE-DEPENDENCE; EXTERNAL TONES; GEKKO-GECKO; HAIR-CELLS;
PAPILLAE; TILIQUA; EAR
AB Lizard families can be grouped into larger units comprising those families that are closely related and whose auditory papillae are morphologically very similar. Based on the few species studied at that time [Manley, G.A., 1997. Diversity in hearing-organ structure and the characteristics of spontaneous otoacoustic emissions in lizards. In: Lewis, E.R., Long, G.R., Lyon, R.F., Narins, P.M., Steele, C.R. (Eds.), Diversity in Auditory Mechanics. World Scientific Publishing Co., Singapore, pp. 32-38], it was suggested that SOAE spectral patterns are strongly influenced by papillar anatomy. However, in two family groups, only one single species has been studied and we have no data on the regularity of pattern within related lizard families. Within the group of skink-like lizards, whose papillae all have salletal tectorial structures, the only detailed SOAE studies so far were on the skink genus Tiliqua. To ascertain the similarity of SOAE in species from families related to the skinks, we have studied one species each from two families that are closely related to skinks, the Cordylidae (Girdle-tailed lizards) and the Gerrhosauridae (plated lizards). Gerrhosaurus and Cordylus have a similar number and amplitudes of SOAE to Tiliqua (Skinkidae). The maximal frequency shifts of SOAE under the influence of external tones is also similar to that of Tiliqua. However, the maximal suppression and maximal facilitation are smaller. in general, the patterns displayed by the SOAE of lizards of these two new families are recognizably similar to the skink Tiliqua, suggesting that the anatomy of the papilla and the tectorial structures do play an important role in determining how SOAE are manifested in papillae that possess tectorial sallets. (C) 2009 Elsevier B.V. All rights reserved.
C1 Tech Univ Munich, Lehrstuhl Zool, D-85350 Freising Weihenstephan, Germany.
RP Manley, GA (reprint author), Tech Univ Munich, Lehrstuhl Zool, Hochfeldweg 2, D-85350 Freising Weihenstephan, Germany.
EM geoffrey.manley@wzw.tum.de
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NR 33
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 58
EP 66
DI 10.1016/j.heares.2009.05.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600006
PM 19539017
ER
PT J
AU Chang, A
Eastwood, H
Sly, D
James, D
Richardson, R
O'Leary, S
AF Chang, Andrew
Eastwood, Hayden
Sly, David
James, David
Richardson, Rachael
O'Leary, Stephen
TI Factors influencing the efficacy of round window dexamethasone
protection of residual hearing post-cochlear implant surgery
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implantation; Round window membrane; Dexamethasone;
Pharmacokinetic; Residual hearing
ID EAR DRUG-DELIVERY; SPIRAL LIGAMENT FIBROCYTES; INTRATYMPANIC
DEXAMETHASONE; ACOUSTIC HEARING; GUINEA-PIG; MODEL; PHARMACOKINETICS;
INTRACOCHLEAR; THERAPY; CELLS
AB Aim: To protect hearing in an experimental model of cochlear implantation by the application of dexamethasone to the round window prior to surgery. The present study examined the dosage and timing relationships required to optimise the hearing protection.
Methods: Dexamethasone or saline (control) was absorbed into a pledget of the carboxymethylcellulose and hyaluronic acid and applied to the round window of the guinea pig prior to cochlear implantation. The treatment groups were 2% w/v dexamethasone for 30, 60 and 120 min; 20% dexamethasone applied for 30 min. Auditory sensitivity was determined pre-operatively, and at I week after surgery, with pure-tone auditory brainstem response audiometry (2-32 kHz). Cochlear implantation was performed via a cochleostomy drilled into the basal turn of the cochlea, into which a miniature cochlear implant dummy electrode was inserted using soft-surgery techniques.
Results: ABR thresholds were elevated after cochlear implantation, maximally at 32 kHz and to a lesser extent at lower frequencies. Thresholds were less elevated after dexamethasone treatment, and the hearing protection improved when 2% dexamethasone was applied to the round window for longer periods of time prior to implantation. The time that dexamethasone need be applied to achieve hearing protection could be reduced by increasing the concentration of steroid, with a 20% application for 30 min achieving similar levels of protection to a 60 min application of 2% dexamethasone.
Conclusions: Hearing protection is improved by increasing the time that dexamethasone is applied to the round window prior to cochlear implantation, and the waiting time can be reduced by increasing the steroid concentration. These results suggest that the diffusion dexamethasone through the cochlea is the prime determinant of the extent of hearing protection. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
C1 [Chang, Andrew; Eastwood, Hayden; Sly, David; James, David; Richardson, Rachael; O'Leary, Stephen] Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
[Richardson, Rachael; O'Leary, Stephen] Bion Ear Inst, Melbourne, Vic 3002, Australia.
RP O'Leary, S (reprint author), Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, 32 Gisborne St, Melbourne, Vic 3002, Australia.
EM sjoleary@unimelb.edu.au
FU National Health and Medical Research Council Australia; Garnett Passe
and Rodney Williams Memorial Foundation; NIDCD [HHS-N-263-2007-00053-C];
National Institute on Deafness and Other Communication Disorders,
National Institutes of Health [DC 01368]
FX Project grants from the National Health and Medical Research Council
Australia and Otolaryngology Scholarship from the Garnett Passe and
Rodney Williams Memorial Foundation. Helen Feng for manufacturing
electrode arrays. Maria Clark and Prudence Nielsen for preparing
histological materials. Dr. Stuart Galloway and St. Vincent's Hospital
Anatomical Pathology Department for histological analysis. Dr. James
Fallon for providing the ABR analysis program (NIDCD Contract
HHS-N-263-2007-00053-C; PI: RK Shepherd). Salt A, Washington University
Cochlear Fluids Simulator: Version 1.6 available from http:
//oto.wustl.edu/cochlea/model.htm. (This program was developed and is
made available by Grant funding (DC 01368) from the National Institute
on Deafness and Other Communication Disorders, National Institutes of
Health.)
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NR 39
TC 37
Z9 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 67
EP 72
DI 10.1016/j.heares.2009.05.010
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600007
PM 19539739
ER
PT J
AU Pap, P
Koszeghy, A
Szucs, G
Rusznak, Z
AF Pap, Pal
Koszeghy, Aron
Szucs, Geza
Rusznak, Zoltan
TI Cytoplasmic Ca2+ concentration changes evoked by cholinergic stimulation
in primary astrocyte cultures prepared from the rat cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE Glia; Muscarinic receptors; Immunochemistry; Q-PCR; Fluo-4
ID MUSCARINIC ACETYLCHOLINE-RECEPTORS; CENTRAL-NERVOUS-SYSTEM; CORTICAL
ASTROCYTES; GLIAL-CELLS; IN-VIVO; CALCIUM; NEURONS; MODULATION;
RESPONSES; SLICES
AB The involvement of astrocytes in the cholinergic modulation of the cochlear nucleus has been studied using primary astrocyte cultures prepared from this nucleus. The cells were loaded with the membrane permeable form of the fluorescent Ca2+ indicator Fluo-4, and carbachol-induced Ca2+ concentration increases were monitored using an imaging system. In the presence of cholinergic stimulation 36.3% of the cells produced Ca2+ transients. The time course of the transients was variable; 45.0% of the responding cells showed only a rapid Ca2+ concentration increase, while in 50.5% of the astrocytes the fast component was followed by a slow plateau phase. Using muscarine as well as general and more specific cholinergic antagonists (atropine, pirenzepine, 4-DAMP and hexamethonium), the role of the M3 and (to a smaller extent) M1 muscarinic acetylcholine receptors could be demonstrated in the genesis of the carbachol-induced Ca2+ transients. The presence of these two subtypes of muscarinic receptors has been confirmed at both mRNA (Q-PCR) and protein (immunocytochemistry) levels. Our data demonstrate the responsiveness of the cochlear astrocytes towards cholinergic stimulation, suggesting that they may have roles in mediating the effects of cholinergic modulation in the rat cochlear nucleus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Pap, Pal; Koszeghy, Aron; Szucs, Geza; Rusznak, Zoltan] Univ Debrecen, Dept Physiol, Med & Hlth Sci Ctr, H-4012 Debrecen, Hungary.
RP Rusznak, Z (reprint author), Univ Debrecen, Dept Physiol, Med & Hlth Sci Ctr, POB 22,Nagyerdei Krt 98, H-4012 Debrecen, Hungary.
EM rz@phys.dote.hu
FU Hungarian Scientific Research Fund [OTKA K-72812, NK-61412]
FX This work was supported by Grants from the Hungarian Scientific Research
Fund (OTKA K-72812, NK-61412). The authors are indebted to Mrs. Ibolya
Varga for her skilled technical assistance.
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NR 54
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 73
EP 83
DI 10.1016/j.heares.2009.05.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600008
PM 19497356
ER
PT J
AU El-Badry, MM
McFadden, SL
AF El-Badry, Mohamed M.
McFadden, Sandra L.
TI Evaluation of inner hair cell and nerve fiber loss as sufficient
pathologies underlying auditory neuropathy
SO HEARING RESEARCH
LA English
DT Article
DE Auditory neuropathy; Inner hair cells; Auditory nerve; Carboplatin;
Auditory brainstem response; Cochlea; Auditory evoked potentials
ID PRODUCT OTOACOUSTIC EMISSIONS; SUMMATING POTENTIALS; CARBOPLATIN;
CHINCHILLAS; ELECTROCOCHLEOGRAPHY; CONSEQUENCES; SYNCHRONY; DAMAGE
AB Auditory neuropathy is a hearing disorder characterized by normal function of outer hair cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions (OAEs), with absent or severely dys-synchronized auditory brainstem responses (ABRs). To determine if selective lesions of inner hair cells (IHCs) and auditory nerve fibers (ANFs) can account for these primary clinical features of auditory neuropathy, we measured physiological responses from chinchillas with large lesions of ANFs (about 85%) and IHCs (45% loss in the apical half of the cochlea; 73% in the basal half). Distortion product OAEs and CM potentials were significantly enhanced, whereas summating potentials and compound action potentials (CAPs) were significantly reduced. CAP threshold was elevated by 7.5 dB, but response synchrony was well preserved down to threshold levels of stimulation. Similarly, ABR threshold was elevated by 5.6 dB, but all waves were present and well synchronized down to threshold levels in all animals. Thus, large lesions of IHCs and ANI's reduced response amplitudes but did not abolish or severely dys-synchronize CAPs or ABRs. Pathologies other than or in addition to ANF and IHC loss are likely to account for the evoked potential dys-synchrony that is a clinical hallmark of auditory neuropathy in humans. (C) 2009 Elsevier B.V. All rights reserved.
C1 [El-Badry, Mohamed M.] Menia Univ, El Minia Univ Hosp, Audiol Unit, Dept Otolaryngol, El Minia, Egypt.
[McFadden, Sandra L.] Western Illinois Univ, Dept Psychol, Macomb, IL 61455 USA.
RP McFadden, SL (reprint author), Menia Univ, El Minia Univ Hosp, Audiol Unit, Dept Otolaryngol, El Minia, Egypt.
EM elbadrymm@hotmail.com; sl-mcfadden@wiu.edu
FU NIH/NIDCD [P01 DC03600]
FX The authors gratefully acknowledge the invaluable assistance of Dalian
Ding, Center for Hearing and Deafness, State University of New York at
Buffalo, for performing all histology. This research was supported by
NIH/NIDCD Grant P01 DC03600 (SLM).
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NR 42
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 84
EP 90
DI 10.1016/j.heares.2009.06.003
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600009
PM 19531376
ER
PT J
AU Nava, E
Bottari, D
Bonfioli, F
Beltrame, MA
Pavani, F
AF Nava, Elena
Bottari, Davide
Bonfioli, Francesca
Beltrame, Millo Achille
Pavani, Francesco
TI Spatial hearing with a single cochlear implant in late-implanted adults
SO HEARING RESEARCH
LA English
DT Article
DE Spatial hearing; Monaural localisation; Cochlear implant; Auditory
plasticity
ID SOUND LOCALIZATION; SPEECH-PERCEPTION; ABILITIES; BENEFITS; USERS;
SPACE; EARS
AB We assessed sound localisation abilities of late-implanted adults fitted with a single cochlear implant (Cl) and examined whether these abilities are affected by the duration of implant use. Ten prelingually and four postlingually deafened adults who received a unilateral Cl were tested in a sound-source identification task. Above chance performance was observed in those prelingual Cl recipients who had worn their implant for longer time (9 years on average), revealing some monaural sound localisation abilities in this population but only after extensive Cl use. On the contrary, the four postlingual recipients performed equal or better with respect to the best prelingual participants despite shorter experience with the monaural implant (11 months on average). Our findings reveal that some sound localisation ability can emerge in prelingually deafened adults fitted with a single implant, at least in a controlled laboratory setting. This ability, however, appears to emerge only after several years of Cl use. Furthermore, the results of four postlingually deafened adults suggest that early experience with auditory cues may result in more rapid acquisition of spatial hearing with a single Cl. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Nava, Elena; Pavani, Francesco] Univ Trent, Ctr Mind Brain Sci, I-38068 Rovereto, TN, Italy.
[Bottari, Davide; Pavani, Francesco] Univ Trent, Dept Cognit Sci & Educ, I-38068 Rovereto, TN, Italy.
[Bonfioli, Francesca; Beltrame, Millo Achille] Hosp Santa Maria del Carmine, Grp Impianti Cocleari, Rovereto, Italy.
RP Nava, E (reprint author), Univ Trent, Ctr Mind Brain Sci, Corso Bettini 31, I-38068 Rovereto, TN, Italy.
EM elena.nava@unitn.it; francesco.pavani@unitn.it
RI Pavani, Francesco/B-4836-2010
FU Ministero dell'Universita e della Ricerca (Italy) [2006118540004];
Comune di Rovereto (Italy); Provincia Autonoma di Trento [PAT-CRS 2008]
FX F.P. was supported by a PRIN Grant (Prot. 2006118540004) from Ministero
dell'Universita e della Ricerca (Italy), a grant from Comune di Rovereto
(Italy), and a Grant from Provincia Autonoma di Trento (PAT-CRS 2008).
The authors are grateful to Wesley Grantham for reading so carefully the
previous version of the manuscript and for many helpful suggestions.
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NR 22
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 91
EP 98
DI 10.1016/j.heares.2009.06.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600010
PM 19539018
ER
PT J
AU Apoux, F
Healy, EW
AF Apoux, Frederic
Healy, Eric W.
TI On the number of auditory filter outputs needed to understand speech:
Further evidence for auditory channel independence
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 2nd Joint Conference of the
Acoustical-Society-of-America/European-Acoustics-Association
CY JUN 29-JUL 04, 2008
CL Paris, FRANCE
SP Acoust Soc Amer, European Acoust Assoc, Soc Francaise Acoust
DE Peripheral filtering; Speech recognition; Glimpsing; Auditory channel
independence
ID NORMAL-HEARING LISTENERS; CONSONANT IDENTIFICATION; INTERFERING-SPEECH;
ARTICULATION INDEX; TEMPORAL CUES; NOISE; FREQUENCY; INTELLIGIBILITY;
RECOGNITION; MASKING
AB The number of auditory filter outputs required to identify phonemes was estimated in two experiments. Stimuli were divided into 30 contiguous equivalent rectangular bandwidths (ERB(N)) spanning 80-7563 Hz. Normal-hearing listeners were presented with limited numbers of bands having frequency locations determined randomly from trial to trial to provide a general view, i.e., irrespective of specific band location, of the number of 1-ERB(N)-wide speech bands needed to identify phonemes. The first experiment demonstrated that 20 such bands are required to accurately identify vowels, and 16 are required to identify consonants. In the second experiment, speech-shaped noise or time-reversed speech was introduced to the non-speech bands at various signal-to-noise ratios. Considerably elevated noise levels were necessary to substantially affect phoneme recognition, confirming a high degree of channel independence in the auditory system. The independence observed between auditory filter outputs supports current views of speech recognition in noise in which listeners extract and combine pieces of information randomly distributed both in time and frequency. These findings also suggest that the ability to partition incoming sounds into a large number of narrow bands, an ability often lost in cases of hearing impairment or cochlear implantation, is critical for speech recognition in noise. Published by Elsevier B.V.
C1 [Apoux, Frederic] Ohio State Univ, Dept Speech & Hearing Sci, Speech Psychoacoust Lab, Columbus, OH 43210 USA.
RP Apoux, F (reprint author), Ohio State Univ, Dept Speech & Hearing Sci, Speech Psychoacoust Lab, 110 Pressey Hall,1070 Carmack Rd, Columbus, OH 43210 USA.
EM fred.apoux@gmail.com; healy.66@osu.edu
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NR 56
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 99
EP 108
DI 10.1016/j.heares.2009.06.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600011
PM 19539016
ER
PT J
AU Zallocchi, M
Meehan, DT
Delimont, D
Askew, C
Garige, S
Gratton, MA
Rothermund-Franklin, CA
Cosgrove, D
AF Zallocchi, Marisa
Meehan, Daniel T.
Delimont, Duane
Askew, Charles
Garige, Suneetha
Gratton, Michael Anne
Rothermund-Franklin, Christie A.
Cosgrove, Dominic
TI Localization and expression of clarin-1, the Clrn1 gene product, in
auditory hair cells and photoreceptors
SO HEARING RESEARCH
LA English
DT Article
DE Usher syndrome; Clarin-1; Stereocilia; Connecting cilia; Ribbon synapse
ID USHER PROTEIN NETWORK; ANKLE-LINK COMPLEX; EAR SENSORY CELLS; SYNDROME
TYPE IIA; INNER-EAR; RIBBON SYNAPSES; MYOSIN VIIA; MUTATIONS; MOUSE;
HARMONIN
AB The Usher syndrome 3A (CLRN1) gene encodes clarin-1, which is a member of the tetraspanin family of transmembrane proteins. Although identified more than 6 years ago, little is known about its localization or function in the eye and ear. We developed a polyclonal antibody that react with all clarin-1 isoforms and used it to characterize protein expression in cochlea and retina. In the cochlea, we observe clarin-1 expression in the stereocilia of PO mice, and in synaptic terminals present at the base of the auditory hair cells from E18 to P6. In the retina, clarin-1 localizes to the connecting cilia, inner segment of photo-receptors and to the ribbon synapses. RT-PCR from PO cochlea and P28 retina show mRNAs encoding only isoforms 2 and 3. Western blots show that only isoform 2 is present in protein extracts from these same tissues. We examined clarin-1 expression in the immortomouse-derived hair cell line UB/OC-1. Only isoform 2 is expressed in UB/OC-1 at both mRNA and protein levels, suggesting this isoform is biologically relevant to hair cell function. The protein co-localizes with microtubules and post-transgolgi vesicles. The subcellular localization of clarin-1 in hair cells and photoreceptors suggests it functions at both the basal and apical poles of neurosensoriepithelia. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Cosgrove, Dominic] Boys Town Natl Res Hosp, Natl Usher Syndrome Ctr, Omaha, NE 68131 USA.
[Askew, Charles; Gratton, Michael Anne] Univ Penn, Auditory Res Lab, Dept Otorhinolaryngol, HNS, Philadelphia, PA 19104 USA.
[Rothermund-Franklin, Christie A.; Cosgrove, Dominic] Univ Nebraska, Med Ctr, Omaha, NE USA.
RP Cosgrove, D (reprint author), Boys Town Natl Res Hosp, Natl Usher Syndrome Ctr, 555 N 30th St, Omaha, NE 68131 USA.
EM zallocchim@boystown.org; meehand@boystown.org; delimontd@boystown.org;
garriges@boystown.org; mgratton@slu.edu.com;
crothermund-franklin@unmc.edu; cosgrove@boystown.org
FU NCRR, NIH [C06 RR17417-01]; [R01 DC004844]; [R01 DC 006442]
FX Supported by R01 DC004844 (to D.C.) and R01 DC 006442 (to M.A.G.). The
authors gratefully acknowledge Skip Kennedy for expert preparation of
figures, Mathew Holley and Dr. Marilyn Farquhar for the kind gift of
UB/OC-1 cells and the mannosidase 11 antibodies, respectively. Confocal
microscopy was conducted at the Integrative Biological Imaging Facility
at Creighton University, Omaha, NE. This facility was constructed with
support from C06 Grant RR17417-01 from the NCRR, NIH.
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NR 65
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 109
EP 120
DI 10.1016/j.heares.2009.06.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600012
PM 19539019
ER
PT J
AU Jung, HH
Kim, HJ
Im, GJ
Chang, J
Choi, J
Chae, SW
AF Jung, Hak Hyun
Kim, Hyung Jin
Im, Gi Jung
Chang, Jiwon
Choi, June
Chae, Sung Won
TI Differential protein expression profiles in salicylate ototoxicity of
the mouse cochlea
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Ototoxicity; Salicylate; Mouse
ID CELL-PROLIFERATION; HAIR-CELLS; CALMODULIN; APOPTOSIS; ASPIRIN
AB The purpose of this study was to investigate protein expression profiles of salicylate ototoxicity using proteomic analysis, and to identify whether salicylates induce apoptosis in organotypic culture of mouse cochlear cells. The adult mice were injected intraperitoneally with 400 mg/kg of sodium salicylate. Approximately 30 dB threshold shift was observed 3 h after the injection, and the hearing threshold returned to normal range within 3 days. Proteomic analysis of mouse cochlea was performed 3 h after salicylate injection, because this was the time to show maximal ototoxic effect in salicylate intoxication. Expression pattern of proteomic analysis at 3 h was compared with those of normal cochlea and cochlea 3 days after salicylate injection. Sixteen proteins were transiently up-regulated threefolds or more at 3 h after the injection compared with normal cochlea, and three proteins were down-regulated at 3 h. Similar protein expression profiles were also observed between normal and 3 days group. These up-regulated and down-regulated proteins at 3 h were analyzed by MALDI-TOF MS. The mRNA expressions of nine selected genes from 16 up-regulated protein profiles were also investigated by RT-PCR, and their expression levels at 3 h were found to be higher than those of normal cochlea. We also confirmed the ototoxicity of salicylate in organotypic culture of cochlear cells using MTT assay, Hoechst staining and DNA laddering assay in vitro, and found that salicylate decreased the viability of cells in a time and dose-dependent manner, and that induced apoptosis in organotypic culture of cochlear cells. This study demonstrated that some proteins can be related to salicylate ototoxicity, and provides basic information about candidate proteins which are related to pathologic changes in salicylate-induced ototoxicity. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Jung, Hak Hyun; Kim, Hyung Jin; Im, Gi Jung; Chang, Jiwon; Choi, June; Chae, Sung Won] Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul 136705, South Korea.
RP Jung, HH (reprint author), Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Anam Dong 5 Ga 126-1, Seoul 136705, South Korea.
EM ranccoon@naver.com
RI Choi, June/E-7063-2013
FU Communication Disorders Center, Korea University, Korea; Brain Korea 21.
FX The authors thank Seo Jin Kim, and Ji Hye Lee for helpful technical
assistance. This study was supported by the Communication Disorders
Center, Korea University, Korea and the Brain Korea 21.
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NR 22
TC 2
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 121
EP 128
DI 10.1016/j.heares.2009.06.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600013
PM 19540324
ER
PT J
AU Xu, L
Zhou, N
Chen, XW
Li, YX
Schultz, HM
Zhao, XY
Han, DM
AF Xu, Li
Zhou, Ning
Chen, Xiuwu
Li, Yongxin
Schultz, Heather M.
Zhao, Xiaoyan
Han, Demin
TI Vocal singing by prelingually-deafened children with cochlear implants
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implants; Vocal singing; Pediatric; Pitch; Rhythm
ID MANDARIN-SPEAKING CHILDREN; MUSIC PERCEPTION; TONE PRODUCTION;
PRODUCTION SKILLS; SONG RECOGNITION; HEARING; PITCH; LISTENERS;
RECIPIENTS; ABILITY
AB The coarse pitch information in cochlear implants might hinder the development of singing in prelingually-deafened pediatric users. In the present study, seven prelingually-deafened children with cochlear implants (5.4-12.3 years old) sang one song that was the most familiar to him or her. The control group consisted of 14 normal-hearing children (4.1-8.0 years old). The fundamental frequencies (F0) of each note in the recorded songs were extracted. The following five metrics were computed based on the reference music scores: (1) F0 contour direction of the adjacent notes, (2) F0 compression ratio of the entire song, (3) mean deviation of the normalized F0 across the notes, (4) mean deviation of the pitch intervals, and (5) standard deviation of the note duration differences. Children with cochlear implants showed significantly poorer performance in the pitch-based assessments than the normal-hearing children. No significant differences were seen between the two groups in the rhythm-based measure. Prelingually-deafened children with cochlear implants have significant deficits in singing due to their inability to manipulate pitch in the correct directions and to produce accurate pitch height. Future studies with a large sample size are warranted in order to account for the large variability in singing performance. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Xu, Li; Zhou, Ning; Schultz, Heather M.] Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
[Chen, Xiuwu; Li, Yongxin; Zhao, Xiaoyan; Han, Demin] Beijing Tongren Hosp, Beijing Inst Otorhinolaryngol, Dept Otolaryngol, Beijing, Peoples R China.
RP Xu, L (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
EM xul@ohio.edu
FU NIH NIDCD [R03 DC006161, R15 DC009504]; Advanced Bionics Corporation
FX The authors express appreciation to Natalie Bevilacqua, Jiong Hu, and
Cyndi Welch for their technique assistance. Three anonymous reviewers
provided useful comments to an early version of the manuscript. This
work was supported by NIH NIDCD Grant Nos. R03 DC006161 and R15 DC009504
and Advanced Bionics Corporation.
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NR 36
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 129
EP 134
DI 10.1016/j.heares.2009.06.011
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600014
PM 19560528
ER
PT J
AU DeCasper, AJ
Prescott, P
AF DeCasper, Anthony J.
Prescott, Phyllis
TI Lateralized processes constrain auditory reinforcement in human newborns
SO HEARING RESEARCH
LA English
DT Article
DE Human newborn; Perception; Auditory reinforcement; Functional
lateralization of audition; Auditory development; Auditory spectral
processing; Rapid variation in audition
ID MATERNAL SPEECH; FETAL; PERCEPTION; EXPERIENCE; LANGUAGE; INFANTS;
SOUNDS; DISCRIMINATION; RECOGNITION; RESPONSES
AB We investigated operant sucking response learning in human newborns. Auditory reinforcers always occurred monaurally to see whether their potency differed between ears. Experiment I - we controlled the reinforcers, either intrauterine heartbeat sounds or unfamiliar speech, while infants chose which ear received it. Experiment 2 - we controlled the reinforcers and the receiving ear. Unfamiliar speech reinforced learning only if infants could use their right ear and heartbeats reinforced learning only if infants could use their left ear. Experiment 3 - we controlled the ear while infants chose between their mothers' vs. a stranger's voice and between their mothers' vs. a foreign language. The more familiar speech reinforced learning only if infants could use their left ear. We proposed reinforcers' potencies differed between ears because the newborn's auditory system, just like adult's, optimizes their perceptual clarity by left-lateralized processing of their rapid temporal variations and right-lateralized processing of their longer-lasting spectral characteristics. (C) 2009 Elsevier B.V. All rights reserved.
C1 [DeCasper, Anthony J.; Prescott, Phyllis] UNC Greensboro, Dept Psychol, Greensboro, NC 27402 USA.
RP DeCasper, AJ (reprint author), UNC Greensboro, Dept Psychol, Greensboro, NC 27402 USA.
EM decasper@uncg.edu
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NR 49
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 135
EP 141
DI 10.1016/j.heares.2009.06.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600015
PM 19563874
ER
PT J
AU Savel, S
AF Savel, Sophie
TI Individual differences and left/right asymmetries in auditory space
perception. I. Localization of low-frequency sounds in free field
SO HEARING RESEARCH
LA English
DT Article
DE Hearing; Auditory localization; Individual differences; Binaural cues;
Learning
ID CORTICAL REPRESENTATION; SPATIAL LOCALIZATION; RIGHT-HEMISPHERE; HUMAN
LISTENERS; NEARBY SOURCES; LATERALIZATION; HUMANS; PERFORMANCES;
RESPONSES; HEARING
AB The number of subjects in studies on human spatial hearing is generally small. Therefore, individual differences and the factors underlying variability are unknown. In this study, we investigated across-listener variability in auditory localization abilities in a group of 50 naive adults with normal hearing. Targets were trains of low-frequency noise bursts presented to I of 12 hidden speakers in the azimuthal plane. We observed less across-listener variability in the variance of individual responses but more in the root-mean-square and signed errors, which tended to increase with target angle. One third of the listeners demonstrated systematically smaller signed errors with left-sided targets than with right-sided ones. These asymmetries were observed less frequently in left-handers and females than in right-handers and males. Performance was not correlated with age. About 4 of 6 listeners trained with sensory feedback showed no reduction of asymmetries with training but rather showed a reduction in errors on their "best" side. Across-listener variability in the asymmetry of brain organization, notably linked to handedness or gender, is discussed. (C) 2009 Elsevier B.V. All rights reserved.
C1 CNRS, Equipe Acoust Percept & Informat Musicale, UPR 7051, Lab Mecan & Acoust, F-13402 Marseille 20, France.
RP Savel, S (reprint author), CNRS, Equipe Acoust Percept & Informat Musicale, UPR 7051, Lab Mecan & Acoust, 31 Chemin Joseph Aiguier, F-13402 Marseille 20, France.
EM savel@lma.cnrs-mrs.fr
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Zatorre RJ, 2002, NAT NEUROSCI, V5, P905, DOI 10.1038/nn904
NR 64
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2009
VL 255
IS 1-2
BP 142
EP 154
DI 10.1016/j.heares.2009.06.013
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 490QO
UT WOS:000269516600016
PM 19567263
ER
PT J
AU Ishiyama, A
Mowry, SE
Lopez, IA
Ishiyama, G
AF Ishiyama, Akira
Mowry, Sarah E.
Lopez, Ivan A.
Ishiyama, Gail
TI Immunohistochemical distribution of basement membrane proteins in the
human inner ear from older subjects
SO HEARING RESEARCH
LA English
DT Article
DE Collagen; Nidogen; Laminin; alpha-Dystroglycan; Tenascin-C; Aging human
temporal bone
ID EXTRACELLULAR-MATRIX PROTEINS; QUIET-AGED GERBILS; ALPORT-SYNDROME; IV
COLLAGEN; DYSTROGLYCAN EXPRESSION; ALPHA-DYSTROGLYCAN; STRIA VASCULARIS;
TENASCIN-C; VESTIBULAR ENDORGANS; TISSUE DISTRIBUTION
AB The immunolocalization of several basement membrane (BM) proteins was investigated in vestibular endorgans microdissected from temporal bones obtained from subjects with a documented normal auditory and vestibular function (n = 5, average age = 88 years old). Fluorescent immunostaining using antibodies directed at collagen IV alpha 2, nidogen-1, laminin-beta 1, alpha-dystroglycan, and tenascin-C was applied to cryosections from human cochlea, cristae ampullares, utricular and saccular maculae. Collagen IV alpha 2, nidogen-1, and laminin-beta 2 localized to all subepithelial cochlear BMs, Reissner's membrane, strial and spiral ligamental perineural and perivascular BMs, and the spiral limbus. Tenascin-C localized to the basilar membrane and the osseous spiral lamina. alpha-Dystroglycan localized to most cochlear BMs except those in the spiral ligament, basilar membrane and spiral limbus. Collagen IV, nidgen-1, and laminin-beta 2 localized to the subepithelial BMs of the maculae and cristae ampullares, and the perineural and perivascular BMs within the underlying stroma. The BM underlying the transitional and dark cell region of the cristae ampullares also expressed collagen IV, nidgen-1, and laminin-beta 2. Tenascin-C localized to the subepithelial BMs of the utricular maculae and cristae ampullares, and to calyx-like profiles throughout the vestibular epithelium, but not to the perineural and perivascular BMs. alpha-Dystroglycan colocalized with aquaporin-4 in the basal vestibular supporting cell, and was also expressed in the subepithelial BMs, as well as perivascular and perineural BMs. This study provides the first comprehensive immunolocalization of these ECM proteins in the human inner ear. The validity of the rodent models for inner ear disorders secondary to BM pathologies was confirmed as there is a high degree of conservation of expression of these proteins in the human inner ear. This information is critical to begin to unravel the role that BMs may play in human inner ear physiology and audiovestibular pathologies. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ishiyama, Gail] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.
[Ishiyama, Akira; Mowry, Sarah E.; Lopez, Ivan A.] Div Head & Neck, Dept Surg, Los Angeles, CA USA.
RP Ishiyama, G (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Box 951769,3-250 RNRC, Los Angeles, CA 90095 USA.
EM gishiyama@mednet.ucla.edu
FU National Institutes of Health; National Institute on Deafness and Other
Communication Disorders (NIDCD) [DC 008635, DC 005028, DC 005187]
FX Grant Support: National Institutes of Health Grants, National Institute
on Deafness and Other Communication Disorders (NIDCD) DC 008635; DC
005028, DC 005187.
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NR 71
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 1
EP 14
DI 10.1016/j.heares.2009.03.014
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500001
PM 19348877
ER
PT J
AU Billings, CJ
Tremblay, KL
Stecker, GC
Tolin, WM
AF Billings, Curtis J.
Tremblay, Kelly L.
Stecker, G. Christopher
Tolin, Wendy M.
TI Human evoked cortical activity to signal-to-noise ratio and absolute
signal level
SO HEARING RESEARCH
LA English
DT Article
DE Cortical auditory evoked potentials (CAEPs); Event-related potentials
(ERPs); Signals in noise; Signal-to-noise ratio (SNR); N1; Auditory
cortex; Hearing aids
ID SENSORINEURAL HEARING-LOSS; EVENT-RELATED POTENTIALS; BROAD-BAND NOISE;
NEURAL REPRESENTATION; AUDITORY-CORTEX; BEHAVIORAL MEASURES;
STIMULUS-INTENSITY; AMPLIFIED SPEECH; RESPONSES; SOUND
AB The purpose of this study was to determine the effect of signal level and signal-to-noise ratio (SNR) on the latency and amplitude of evoked cortical activity to further our understanding of how the human central auditory system encodes signals in noise. Cortical auditory evoked potentials (CAEPs) were recorded from 15 young normal-hearing adults in response to a 1000 Hz tone presented at two tone levels in quiet and while continuous background noise levels were varied in five equivalent SNR steps. These 12 conditions were used to determine the effects of signal level and SNR level on CAEP components P1, N1, P2, and N2. Based on prior signal-in-noise experiments conducted in animals, we hypothesized that SNR, would be a key contributor to human CAEP characteristics. As hypothesized, amplitude increased and latency decreased with increasing SNR; in addition, there was no main effect of tone level across the two signal levels tested (60 and 75 dB SPL). Morphology of the P1-N1-P2 complex was driven primarily by SNR, highlighting the importance of noise when recording CAEPs. Results are discussed in terms of the current interest in recording CAEPs in hearing aid users. Published by Elsevier B.V.
C1 [Billings, Curtis J.] Portland VA Med Ctr, Natl Ctr Rehabilitat Auditory Res, Portland, OR 97239 USA.
[Billings, Curtis J.; Tremblay, Kelly L.; Stecker, G. Christopher; Tolin, Wendy M.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA.
RP Billings, CJ (reprint author), Portland VA Med Ctr, Natl Ctr Rehabilitat Auditory Res, 3710 SW US Vet Hosp Rd NCRAR, Portland, OR 97239 USA.
EM curtis.billings2@va.gov; tremblay@u.washington.edu;
cstecker@u.washington.edu; wendyt3@u.washington.edu
FU National Institutes of Health through the National Institute on Deafness
and Other Communication Disorders [F31-DC007296, R01-DC007705,
P30DC004661]
FX The authors thank Richard Folsom and Pamela Souza who contributed to
this work through many helpful discussions and as dissertation committee
members of the first author. The authors are also grateful to the
reviewers for their helpful comments. This work was supported by the
National Institutes of Health through the National Institute on Deafness
and Other Communication Disorders (F31-DC007296, CJ.B.; R01-DC007705,
K.L.T.; P30DC004661).
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NR 59
TC 24
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 15
EP 24
DI 10.1016/j.heares.2009.04.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500002
PM 19364526
ER
PT J
AU Chen, GD
Henderson, D
AF Chen, Guang-Di
Henderson, Donald
TI Cochlear injuries induced by the combined exposure to noise and styrene
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear injury; Styrene ototoxicity; Noise trauma; Noise and chemical
interaction
ID INDUCED HEARING-LOSS; HAIR CELL LOSS; OCCUPATIONAL EXPOSURE; AUDITORY
FUNCTION; GUINEA-PIG; SUPEROXIDE-DISMUTASE; SOLVENT OTOTOXICITY;
CARBON-MONOXIDE; ACOUSTIC TRAUMA; OXIDE ADDUCTS
AB Workers exposed to industrial solvents are also frequently exposed to mechanical noise. In this study, a combination of a continuous noise (100 dB SPL) and an impact noise (110 dB SPL) was used to mimic the noise exposure in the workplace. A noise band of 10-20 kHz was used to induce a cochlear injury in the same cochlear region in the rat as styrene exposure. Styrene levels of 300 and 400 mg/kg were applied to induce outer hair cell (OHC) loss limited to the third row of the middle turn, but without significant cochlear functional loss. The combined exposures of the noise and styrene for 3 weeks caused greater threshold shifts than the noise alone, although the styrene alone did not induce significant threshold shift. Correspondingly, the combined exposures induced OHC losses that were greater than the summated OHC losses induced by the noise and styrene exposure alone. Apoptosis in Deiters cells was also examined after a short-term exposure (7 days) to a combined exposure of a high-level styrene (800 mg/kg) and the noise. The styrene-noise synergistic interaction was also observed in the Deiters cells. The synergistic interaction between the noise and styrene suggests that each of the exposures alone (noise or styrene) may cause stress, temporary alteration, or nonlethal injury in cochlear cells and the combined exposure strengthens the stress leading to cell death. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Chen, Guang-Di; Henderson, Donald] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Chen, GD (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM gchen7@buffalo.edu
FU NIOSH [IR01OH008113]
FX This study is supported by NIOSH Grant IR01OH008113. The authors thank
Ellen Schopp for assistance in animal exposures. The authors also thank
Dr. Eric Bielefeld for his comments.
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NR 49
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 25
EP 33
DI 10.1016/j.heares.2009.04.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500003
PM 19371775
ER
PT J
AU Landsberger, DM
Srinivasan, AG
AF Landsberger, David M.
Srinivasan, Arthi G.
TI Virtual channel discrimination is improved by current focusing in
cochlear implant recipients
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implants; Virtual channels; Current focusing; Current steering;
Psychophysics
ID SPEECH CODING STRATEGY; ELECTRODE CONFIGURATIONS;
ELECTRICAL-STIMULATION; PITCH DISCRIMINATION; SPECTRAL RESOLUTION;
NORMAL-HEARING; RECOGNITION; PERCEPTION; NOISE; USERS
AB Cochlear implant users' spectral resolution is limited by both the number of implanted electrodes and channel interactions between electrodes. Current steering (virtual channels) between two adjacent monopolar electrodes has been used to increase the number of spectral channels across the electrode array. However, monopolar stimulation is associated with large current spread and increased channel interaction. Current focusing across three adjacent electrodes (tripolar stimulation) has been used to reduce electrode current spread and improve channel selectivity. In the present study, current steering and current focusing were combined within a four-electrode stimulation pattern (quadrupolar virtual channels), thereby addressing the need for both increased channels and reduced current spread. Virtual channel discrimination was measured in 7 users of the Advanced Bionics Clarion 11 or HiRes 90K implants; virtual channel discrimination was compared between monopolar and quadrupolar virtual channels at three stimulation sites. The results showed that quadrupolar virtual channels provided better spectral resolution than monopolar virtual channels. The results suggested that quadrupolar virtual channels might provide the "best of both worlds" improving the number of spectral channels while reducing channel interactions. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Landsberger, David M.; Srinivasan, Arthi G.] House Ear Res Inst, Dept Commun & Auditory Neurosci, Los Angeles, CA 90057 USA.
[Srinivasan, Arthi G.] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA.
RP Landsberger, DM (reprint author), House Ear Res Inst, Dept Commun & Auditory Neurosci, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM dlandsberger@hei.org
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NR 35
TC 35
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 34
EP 41
DI 10.1016/j.heares.2009.04.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500004
PM 19383534
ER
PT J
AU Wagoner, JL
Kulesza, RJ
AF Wagoner, Jessica L.
Kulesza, Randy J., Jr.
TI Topographical and cellular distribution of perineuronal nets in the
human cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE Auditory; Hearing; Brainstem
ID CALCIUM-BINDING PROTEINS; SUPERIOR OLIVARY COMPLEX; CHONDROITIN SULFATE
PROTEOGLYCANS; PHYSIOLOGICAL-RESPONSE PROPERTIES; BRAIN
EXTRACELLULAR-MATRIX; SONG CONTROL-SYSTEM; TRAPEZOID BODY;
HORSERADISH-PEROXIDASE; MEDIAL NUCLEUS; RHESUS-MONKEY
AB Specialized constructs of the extracellular matrix termed perineuronal nets surround the soma, primary dendrites and initial axon segment of some but not all neuronal populations in the central nervous system. in an effort to determine the cellular localization of perineuronal nets in the human cochlear nucleus (CN), we first performed a quantitative morphometric study of the human CN. We provide evidence for a laminar organization in the human dorsal cochlear nucleus (DCN; including molecular, granular and deep layers) as in other laboratory animals. Additionally, we find that the human ventral cochlear nucleus (VCN) contains distinct octopus, stellate, globular and spherical bushy cell populations, as described in other species. Using Wisteria floribunda histochemistry in five human brainstems, we identified perineuronal nets in the human cochlear nucleus. Perineuronal nets are associated with the vast majority of octopus and stellate cells in the caudal VCN. In the rostral VCN, dense perineuronal nets are associated with globular bushy cells and faint nets are associated with some spherical bushy cells and stellate cells. Few perineuronal nets are found in the DCN. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Wagoner, Jessica L.; Kulesza, Randy J., Jr.] Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
RP Kulesza, RJ (reprint author), Lake Erie Coll Osteopath Med, Auditory Res Ctr, 1858 W Grandview Blvd, Erie, PA 16509 USA.
EM rkulesza@lecom.edu
FU LECOM Research Collective; Deafness Research Foundation
FX This work was supported by the LECOM Research Collective and a grant
from the Deafness Research Foundation. The authors thank Richard Lukose
and Holli Martinez for technical assistance, Drs. Jack Caldwell and
Michael Bradbury for reading an early version of the manuscript and the
three anonymous reviewers for their many helpful comments.
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NR 64
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 42
EP 53
DI 10.1016/j.heares.2009.04.008
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500005
PM 19383535
ER
PT J
AU Harding, GW
Bohne, BA
AF Harding, Gary W.
Bohne, Barbara A.
TI Relation of focal hair-cell lesions to noise-exposure parameters from a
4-or a 0.5-kHz octave band of noise
SO HEARING RESEARCH
LA English
DT Article
DE Focal lesion; Organ of Corti; Noise-induced hearing loss; Octave band of
noise; Hair cells; Chinchilla
ID INTENSE AUDITORY-STIMULATION; ABR THRESHOLD SHIFTS; INDUCED
HEARING-LOSS; LOW-FREQUENCY NOISE; DPOAE LEVEL SHIFTS;
CHINCHILLA-COCHLEA; HISTOPATHOLOGICAL DAMAGE; INTERRUPTED EXPOSURE;
RETICULAR LAMINA; MOUSE COCHLEA
AB In a previous study, we examined the relation between total energy in a noise exposure and the percentage losses of outer (OHC) and inner (IHC) hair cells in the basal and apical halves of 607 chinchilla cochleae [Harding, G.W., Bohne, B.A., 2004a. Noise-induced hair-cell loss and total exposure energy: analysis of a large data set. J. Acoust. Soc. Am. 115, 2207-2220]. The animals had been exposed continuously to either a 4-kHz octave band of noise (OBN) at 47-108 dB SPL for 0.5 h-36 d, or a 0.5-kHz OBN at 65-128 dB SPL for 3.5 h-433 d. Interrupted exposures were also employed with both OBNs. Post-exposure recovery times ranged from 0 to 913 days. Cluster analysis was used to separate the data into three magnitudes of damage. The data were also separated into recovery times of 0 days (acute) and >0 days (chronic) and the apical and basal halves of the organ of Corti (OC). A substantial part of these hair-cell losses occurred in focal lesions (i.e., >= 50% loss of IHCs, OHCs or both over a distance of >= 0.03 mm). This aspect of the damage from noise was not included in the previous analysis. The present analysis describes, within the same three clusters, the apex-to-base distribution of 1820 focal lesions found in 468 of 660 (71%) noise-exposed cochleae. In these cochleae, OC length in mm was converted to percent distance from the apex. The lesion data were analyzed for location in percent distance from the apex and size (mm) of the lesions. In 55 of 140 (39%) non-noise-exposed, control OCs, there were 186 focal hair-cell lesions, the characteristics of which were also determined. Focal lesions with hair-cell loss >= 50% involved predominantly OHCs, IHCs only, or both OHCs and IHCs (i.e., combined OHC-IHC lesions). The predominantly OHC and combined lesions were pooled together for the analysis. The distributions of lesion location (in percent distance from the apex), weighted by lesion size (in percent of OC length) were tallied in 2%-distance bins. In controls, focal lesions were uniformly distributed from apex to base and 70% of them were pure IHC lesions. In cochleae exposed to the 4-kHz OBN, lesions were distributed throughout the basal half of the OC. In cochleae exposed to the 0.5-kHz OBN, lesions occurred in both halves of the CC. With continuous exposures, 74% of the lesions were predominantly OHC or combined lesions. With interrupted exposures, 52% of the lesions were OHC or combined lesions. Lesion size was generally larger in the chronic compared to acute cochleae with similar exposures. There was a minimum total energy at which focal lesions began to appear and slightly higher energies resulted in nearly all exposed cochleae having focal lesions. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Harding, Gary W.; Bohne, Barbara A.] Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Harding, GW (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA.
EM hardingg@ent.wustl.edu
FU NIOSH [OH003973]; Department of Otolaryngology, Washington University
School of Medicine
FX This work was supported by NIOSH (Grant # OH003973) and the Department
of Otolaryngology, Washington University School of Medicine. The
contents are solely the responsibility of the authors and do not
necessarily represent the official views of NIOSH.
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NR 48
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 54
EP 63
DI 10.1016/j.heares.2009.04.011
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500006
PM 19393307
ER
PT J
AU Fishman, YI
Steinschneider, M
AF Fishman, Yonatan I.
Steinschneider, Mitchell
TI Temporally dynamic frequency tuning of population responses in monkey
primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Auditory cortex; Spectral tuning; Tonotopic organization; Onset
response; Sustained response; Off response; Population coding
ID VOICE ONSET TIME; AWAKE MONKEY; SOUND LOCALIZATION; RECEPTIVE-FIELDS;
CORTICAL-NEURONS; MACAQUE MONKEYS; SINGLE NEURONS;
FUNCTIONAL-ORGANIZATION; ANURAN CEREBELLUM; PITCH PERCEPTION
AB Frequency tuning of auditory cortical neurons is typically determined by integrating spikes over the entire duration of a tone stimulus. However, this approach may mask functionally significant variations in tuning over the time course of the response. To explore this possibility, frequency response functions (FRFs) based on population multiunit activity evoked by pure tones of 175 or 200 ms duration were examined within four time windows relative to stimulus onset corresponding to "on" (10-30 ms), "early sustained" (30-100 ms), "late sustained" (100-175 ms), and "off" (185-235 or 210-260 ms) portions of responses in primary auditory cortex (A1) of 5 awake macaques. FRFs of "on" and "early sustained" responses displayed a good concordance, with best frequencies (BFs) differing, on average, by less than 0.25 octaves. In contrast, FRFs of "on" and "late sustained" responses differed considerably, with a mean difference in BF of 0.68 octaves. At many sites, tuning of "off' responses was inversely related to that of "on" responses, with "off" FRFs displaying a trough at the BF of "on" responses. Inversely correlated "on" and "off' FRFs were more common at sites with a higher "on" BF, thus suggesting functional differences between sites with low and high "on" BF. These results indicate that frequency tuning of population responses in A1 may vary considerably over the course of the response to a tone, thus revealing a temporal dimension to the representation of sound spectrum in A1. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Fishman, Yonatan I.; Steinschneider, Mitchell] Albert Einstein Coll Med, Rose F Kennedy Ctr, Dept Neurol, Bronx, NY 10461 USA.
[Steinschneider, Mitchell] Albert Einstein Coll Med, Rose F Kennedy Ctr, Dept Neurosci, Bronx, NY 10461 USA.
RP Fishman, YI (reprint author), Albert Einstein Coll Med, Rose F Kennedy Ctr, Dept Neurol, Room 322,1410 Pelham Pkwy S, Bronx, NY 10461 USA.
EM yfishman@aecom.yu.edu
FU National Institute of Deafness and Other Communications Disorders
[DC-00657]
FX Grants. Supported by National Institute of Deafness and Other
Communications Disorders Grant DC-00657.
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NR 78
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 64
EP 76
DI 10.1016/j.heares.2009.04.010
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500007
PM 19389466
ER
PT J
AU van Zyl, A
Swanepoel, D
Hall, JW
AF van Zyl, Altelani
Swanepoel, D.
Hall, James W., III
TI Effect of prolonged contralateral acoustic stimulation on transient
evoked otoacoustic emissions
SO HEARING RESEARCH
LA English
DT Article
DE Transient evoked otoacoustic emissions; Contralateral acoustic
stimulation; Medial olivocochlear efferent system; Prolonged
stimulation, Suppression
ID COCHLEAR MICROMECHANICAL PROPERTIES; MEDIAL OLIVOCOCHLEAR SYSTEM;
SUPPRESSION; HUMANS; POTENTIALS; SOUND
AB Although the suppressive effect of the medial olivocochlear system (MOCS) on peripheral auditory active mechanisms is well documented in humans, the effect of efferent inhibition over prolonged periods of acoustic stimulation is less well documented, especially as observed by transient evoked otoacoustic emission (TEOAE) suppression. The present study evaluated the relationship between the duration of contralateral acoustic stimulation and the suppression of TEOAE in 10 normal-hearing adults. TEOAE recordings with linear clicks (60 dB SPL) were measured at four intervals during 15 min of continuous contralateral white noise (45 dB SL), followed by two post-noise recordings. An identical within-subject control condition was recorded without contralateral noise. Experimental and control measurements were repeated three times, on separate days. Results revealed significant and sustained TEOAE amplitude reduction for the entire duration of contralateral stimulation. Suppression increased gradually for the duration of contralateral noise presented, but not sufficiently to be statistically significant. Three minutes after noise termination, TEOAE amplitudes increased to values significantly above control recordings. The MOCS is able to sustain suppression over a prolonged duration of contralateral stimulation, supporting its role as an active modulator of outer hair cell mechanics during ongoing stimuli. (C) 2009 Elsevier B.V. All rights reserved.
C1 [van Zyl, Altelani; Swanepoel, D.; Hall, James W., III] Univ Pretoria, Dept Commun Pathol, ZA-0002 Pretoria, South Africa.
[Swanepoel, D.] Univ Texas Dallas, Callier Ctr Commun Disorders, Dallas, TX 75235 USA.
[Hall, James W., III] Univ Florida, Dept Communicat Disorders, Gainesville, FL USA.
RP Swanepoel, D (reprint author), Univ Pretoria, Dept Commun Pathol, ZA-0002 Pretoria, South Africa.
EM dewet.swanepoel@up.ac.za
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NR 19
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 77
EP 81
DI 10.1016/j.heares.2009.04.013
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500008
PM 19401226
ER
PT J
AU Moffat, G
Adjout, K
Gallego, S
Thai-Van, H
Collet, L
Norena, AJ
AF Moffat, G.
Adjout, K.
Gallego, S.
Thai-Van, H.
Collet, L.
Norena, A. J.
TI Effects of hearing aid fitting on the perceptual characteristics of
tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE Tinnitus; Hearing aid; Tinnitus pitch; Neural plasticity;
Deafferentation
ID PRIMARY AUDITORY-CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; ENHANCED
FREQUENCY DISCRIMINATION; ENRICHED ACOUSTIC ENVIRONMENT; RAT INFERIOR
COLLICULUS; PURE-TONE TRAUMA; COCHLEAR DAMAGE; NEURAL ACTIVITY; NOISE
TRAUMA; CORTICAL PLASTICITY
AB Restoration of auditory input through the use of hearing aids has been proposed as a potentially important means of altering tinnitus among those tinnitus sufferers who experience significant sensorineural hearing loss. In animal models of neural plasticity induced by noise trauma, high-frequency stimulation in deafferented regions of the auditory spectrum has been shown to modulate cortical reorganization after hearing loss, a result which suggests that the neural basis of tinnitus is subject to interference by acoustic stimulation. This study drew on deafferentation models to investigate the effect of hearing aids on the psychoacoustic properties of the tinnitus sensation, using both conventional amplification and high-bandwidth amplification regimes. The tinnitus percept was affected only weakly in the conventional amplification group, and was not at all affected in the high-bandwidth group. The changes observed under conventional, low-to-medium frequency amplification may indicate that the perceptual characteristics of tinnitus depend on the pattern of sensory inputs - notably a contrast in activity between adjacent central auditory regions of more and less afferent activity - while the absence of modifications in the high-bandwidth amplification group suggests limit on the tractability of the tinnitus percept. This limit to the malleability of the tinnitus percept may arise from either the extent of hearing deficits or the duration and robustness of the neuroplastic changes that originally give rise to tinnitus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Moffat, G.; Norena, A. J.] CNRS, UMR 6149, Lab Neurobiol Integrat & Adaptat, F-13331 Marseille 03, France.
[Adjout, K.; Thai-Van, H.; Collet, L.] Univ Lyon, F-69003 Lyon, France.
[Gallego, S.; Thai-Van, H.; Collet, L.] Hop Edouard Herriot, Serv Audiol & Explorat Orofaciales, Hosp Civils Lyon, F-69003 Lyon, France.
[Adjout, K.; Thai-Van, H.; Collet, L.] CNRS, UMR5020, F-69007 Lyon, France.
[Adjout, K.; Thai-Van, H.; Collet, L.] Inst Federatif Neurosci Lyon, F-69677 Lyon, France.
RP Norena, AJ (reprint author), CNRS, UMR 6149, Lab Neurobiol Integrat & Adaptat, 3 Pl Victor Hugo, F-13331 Marseille 03, France.
EM arnaud.norena@univ-provence.fr
FU CNRS; ANR (Agence Nationale pour la Recherche); CIFRE
FX This research was supported by CNRS and ANR (Agence Nationale pour la
Recherche). The first author is supported by a CIFRE scholarship in
partnership with Neurelec, S.A., 2720 Chemin St. Bernard, Vallauris,
F-06220, France.
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NR 73
TC 40
Z9 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 82
EP 91
DI 10.1016/j.heares.2009.04.016
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500009
PM 19409969
ER
PT J
AU Sha, SH
Chen, FQ
Schacht, J
AF Sha, Su-Hua
Chen, Fu-Quan
Schacht, Jochen
TI Activation of cell death pathways in the inner ear of the aging CBA/J
mouse
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Age-related hearing loss; Apoptosis; Oxidative stress; Caspase;
Calpain
ID ISCHEMIC NEURONAL DEATH; INDUCED HEARING-LOSS; OUTER HAIR-CELLS;
OXIDATIVE STRESS; CALORIC RESTRICTION; COCHLEAR PATHOLOGY;
ENDONUCLEASE-G; CYTOCHROME-C; CATHEPSIN-D; APOPTOSIS
AB We have previously demonstrated that oxidative stress increases in the inner ear of aging CBA/J mice and might contribute to the loss of function of the sensory system. We now investigate the activation of cell death pathways in the cochleae of these animals. Middle-aged (112 months) and old (18-26 months) mice with hearing deficits displayed outer hair cell nuclei with apoptotic and, to a lesser extent, necrotic features. Both intrinsic and extrinsic cell death pathways were activated by translocation or post-translational modification of proteins in the aging cochlea as compared to young (3 months) animals. Cytosolic cytochrome c increased, formed a complex with, and activated caspase 9. Endonuclease G translocated to the nuclei of aging outer hair cells suggesting its function as an apoptotic DNase. The cleaved (and hence active) forms of calpain I and calpain 11 increased while active cathepsin D was transiently elevated in middle-aged but not old animals. Finally, increases in the phosphorylation of p38 MAPK and JNK implicated the additional involvement of the MAPK pathway. The results suggest that multiple cell death pathways, all potentially linked to oxidative stress, are activated in hair cells of the auditory organ in aging mice. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sha, Su-Hua; Chen, Fu-Quan; Schacht, Jochen] Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Chen, Fu-Quan] Fourth Mil Med Univ, Dept Otolaryngol, Xian 710032, Peoples R China.
RP Sha, SH (reprint author), Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, 1150 W Med Ctr Dr,5315 B MS 1, Ann Arbor, MI 48109 USA.
EM shasha@umich.edu
FU National Institute on Aging [AC-025164]; National Institute on Deafness
and Other Communication Disorders, NIH [P30 DC-05188]
FX This study was supported by program project Grant AC-025164 from the
National Institute on Aging and core Grant P30 DC-05188 from the
National Institute on Deafness and Other Communication Disorders, NIH.
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NR 45
TC 29
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 92
EP 99
DI 10.1016/j.heares.2009.04.019
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500010
PM 19422898
ER
PT J
AU Dai, M
Nuttall, A
Yang, Y
Shi, XR
AF Dai, Min
Nuttall, Alfred
Yang, Yue
Shi, Xiaorui
TI Visualization and contractile activity of cochlear pericytes in the
capillaries of the spiral ligament
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear pericyte; Capillary of spiral ligament; Diaminofluorescein-2
diacetate (DAF-2DA)
ID ENDOTHELIAL NITRIC-OXIDE; SYNTHASE UP-REGULATION; GUINEA-PIG COCHLEA;
EAR BLOOD-FLOW; RETINAL MICROVASCULATURE; MODIOLAR ARTERY; LUNG
PERICYTES; GROWTH-FACTOR; RAT RETINA; IN-VITRO
AB Pericytes, mural cells located on microvessels, are considered to play an important role in the formation of the vasculature and the regulation of local blood flow in some organs. Little is known about the physiology of cochlear pericytes. in order to investigate the function of cochlear pericytes, we developed a method to visualize cochlear pericytes using diaminofluorescein-2 diacetate (DAF-2DA) and intravital fluorescence microscopy. This method can permit the study of the effect of vasoactive agents on pericytes under the in vivo and normal physiological condition. The specificity of the labeling method was verified by the immunofluorescence labeling of pericyte maker proteins such as desmin, neural proteoglycan (NG2), and thymocyte differentiation antigen 1 (Thy-1). Superfused K(+) and Ca(2+) to the cochlear lateral wall resulted in localized constriction of capillaries at pericyte locations both in vivo and in vitro, while there was no obvious change in cochlear capillary diameters with application of the adrenergic neurotransmitter noradrenaline. The method could be an effective way to visualize cochlear pericytes and microvessels and study lateral wall vascular physiology. Moreover, we demonstrate for the first time that cochlear pericytes have contractility, which may be important for regulation of cochlear blood flow. Published by Elsevier B.V.
C1 [Dai, Min; Nuttall, Alfred; Yang, Yue; Shi, Xiaorui] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr NRC04, Dept Otolaryngol Head & Neck Surg, Portland, OR 97239 USA.
[Nuttall, Alfred] Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Nuttall, Alfred] Shanghai Jiao Tong Univ, Dept Otolaryngol, Renji Hosp, Shanghai 200030, Peoples R China.
[Dai, Min; Shi, Xiaorui] Chinese Acad Med Sci, Inst Microcirculat, Beijing, Peoples R China.
[Dai, Min; Shi, Xiaorui] Peking Union Med Coll, Beijing 100021, Peoples R China.
RP Shi, XR (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr NRC04, Dept Otolaryngol Head & Neck Surg, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM shix@ohsu.edu
RI Dai, Min/B-9908-2012
FU National Institute of Deafness and Other Communications Disorders [NIDCD
DC 00888, NIDCD DC 00105, NIDCD DC 005983 (p30)]
FX This work was supported by National Institute of Deafness and Other
Communications Disorders Grants NIDCD DC 00888, NIDCD DC 00105, and
NIDCD DC 005983 (p30).
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NR 42
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG 11
PY 2009
VL 254
IS 1-2
BP 100
EP 107
DI 10.1016/j.heares.2009.04.018
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 476KH
UT WOS:000268438500011
PM 19422897
ER
PT J
AU Klop, WMC
Frijns, JHM
Soede, W
Briaire, JJ
AF Klop, W. Martin C.
Frijns, Johan H. M.
Soede, Wim
Briaire, Jeroen J.
TI An objective method to measure electrode independence in cochlear
implant patients with a dual-masker forward masking technique
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Current steering; eCAP; Electrode independence; Neural
response imaging
ID SPEECH CODING STRATEGY; ELECTRICAL-STIMULATION; PITCH DISCRIMINATION;
EXCITATION PATTERNS; NEURAL EXCITATION; SPATIAL SPREAD; USERS;
PERCEPTION; ARRAYS; CII
AB This study introduced a dual-masker forward masking technique and evaluated whether this objective method could measure electrode independency in a cochlear implant; more particularly, whether the optimal locations and number of active electrodes could be determined. This method further enabled the investigation of the efficacy of current steering, because the proposed recording method could also be described as applying a sequentially current steered masker.
The paradigm requires 5 frames involving 2 maskers and 1 probe and is referred to as the Apple Core method (MP5-AC). For each recording, both the masker and probe amplitude were varied independently, producing 3-D eCAP plots that showed the eCAP amplitude for independent variations of masker and probe amplitudes. A simple quantitative model was developed to aid interpretation of the results. Theory and model were clinically tested in 14 patients. On the basis of the model, the multi-variate, color-coded plots could be subdivided into seven distinct regions, each depicting a unique relationship between the probe and the maskers. The model's predictions supported interpretation of the results, and indicated independence for the probe electrode contacts only at lower current levels and/or at greater inter-electrode separations. The clinical results revealed a lack of selectivity in the electrode array for stimulus levels larger than 600 mu A. This suggests that sequential current steering is only capable of producing a single excitation area at higher current levels, or smaller electrode distances, without additional loudness correction being applied.
Thus, the MP5-AC paradigm provided insight concerning the independence of electrodes and the efficacy of current steering in clinical patients. However, its current clinical applicability is limited because measurements were adequate only in anesthetized patients. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Klop, W. Martin C.; Frijns, Johan H. M.; Soede, Wim; Briaire, Jeroen J.] Leiden Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-2300 RC Leiden, Netherlands.
RP Frijns, JHM (reprint author), Leiden Univ, Med Ctr, ENT Dept, POB 9600, NL-2300 RC Leiden, Netherlands.
EM j.h.m.frijns@lumc.nl
RI Frijns, Johan/H-6249-2011; Briaire, Jeroen/A-7972-2008
OI Briaire, Jeroen/0000-0003-4302-817X
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NR 44
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 3
EP 14
DI 10.1016/j.heares.2009.03.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100002
PM 19306921
ER
PT J
AU Owens, KN
Coffin, AB
Hong, LS
Bennett, KO
Rubel, EW
Raible, DW
AF Owens, Kelly N.
Coffin, Allison B.
Hong, Lisa S.
Bennett, Keri O'Connell
Rubel, Edwin W.
Raible, David W.
TI Response of mechanosensory hair cells of the zebrafish lateral line to
aminoglycosides reveals distinct cell death pathways
SO HEARING RESEARCH
LA English
DT Article
DE Ototoxicity; Aminoglycoside; Mechanosensory; Lateral line; Zebrafish;
Hair cell
ID GUINEA-PIG COCHLEA; GENTAMICIN-INDUCED OTOTOXICITY; IN-VITRO;
DANIO-RERIO; HEARING-LOSS; CASPASE ACTIVATION; SENSORY EPITHELIA;
AUDITORY FUNCTION; STRUCTURAL BASIS; GENE-EXPRESSION
AB We report a series of experiments investigating the kinetics of hair cell loss in lateral line neuromasts of zebrafish larvae following exposure to aminoglycoside antibiotics. Comparisons of the rate of hair cell loss and the differential effects of acute versus chronic exposure to gentamicin and neomycin revealed markedly different results. Neomycin induced rapid and dramatic concentration-dependent hair cell loss that is essentially complete within 90 min, regardless of concentration or exposure time. Gentamicin-induced loss of half of the hair cells within 90 min and substantial additional loss, which was prolonged and cumulative over exposure times up to at least 24 h. Small molecules and genetic mutations that inhibit neomycin-induced hair cell loss were ineffective against prolonged gentamicin exposure supporting the hypothesis that these two drugs are revealing at least two cellular pathways. The mechanosensory channel blocker amiloride blocked both neomycin and gentamicin-induced hair cell death acutely and chronically indicating that these aminoglycosides share a common entry route. Further tests with additional aminoglycosides revealed a spectrum of differential responses to acute and chronic exposure. The distinctions between the times of action of these aminoglycosides indicate that these drugs induce multiple cell death pathways. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Owens, Kelly N.; Raible, David W.] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA.
[Owens, Kelly N.; Coffin, Allison B.; Rubel, Edwin W.] Univ Washington, Dept Otolaryngol HNS, Seattle, WA 98195 USA.
[Owens, Kelly N.; Coffin, Allison B.; Hong, Lisa S.; Bennett, Keri O'Connell; Rubel, Edwin W.; Raible, David W.] Univ Washington, VM Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
[Hong, Lisa S.; Bennett, Keri O'Connell] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
RP Owens, KN (reprint author), Univ Washington, Dept Biol Struct, Box 357420, Seattle, WA 98195 USA.
EM kowens@u.washington.edu; coffina@u.washington.edu; lisaness@gmail.com;
Keri.Oconnell2@va.gov; rubel@u.washington.edu; draible@u.washington.edu
FU Virginia Merrill Bloedel Hearing Research Center; NIH [DC04661, DC05987,
DC06998, DC00018]
FX Support was provided by the Department of Speech and Hearing Sciences,
the Virginia Merrill Bloedel Hearing Research Center and NIH grants
DC04661; DC05987; DC06998; DC00018.
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NR 94
TC 37
Z9 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 32
EP 41
DI 10.1016/j.heares.2009.03.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100004
PM 19285126
ER
PT J
AU Coffin, AB
Reinhart, KE
Owens, KN
Raible, DW
Rubel, EW
AF Coffin, Allison B.
Reinhart, Katherine E.
Owens, Kelly N.
Raible, David W.
Rubel, Edwin W.
TI Extracellular divalent cations modulate aminoglycoside-induced hair cell
death in the zebrafish lateral line
SO HEARING RESEARCH
LA English
DT Article
DE Hair cell; Ototoxicity; Aminoglycoside; Lateral line; Calcium; Magnesium
ID VESTIBULAR SENSORY EPITHELIA; IN-VITRO; DANIO-RERIO; TRANSDUCER
ADAPTATION; GENTAMICIN EXPOSURE; ACOUSTIC TRAUMA; GUINEA-PIG; INNER-EAR;
MECHANOELECTRICAL TRANSDUCTION; MECHANOTRANSDUCER CHANNEL
AB Aminoglycoside antibiotics cause death of sensory hair cells. Research over the past decade has identified several key players in the intracellular cascade. However, the role of the extracellular environment in aminoglycoside ototoxicity has received comparatively little attention. The present study uses the zebrafish lateral line to demonstrate that extracellular calcium and magnesium ions modulate hair cell death from neomycin and gentamicin in vivo, with high levels of either divalent cation providing significant protection. Imaging experiments with fluorescently-tagged gentamicin show that drug uptake is reduced under high calcium conditions. Treating fish with the hair cell transduction blocker amiloride also reduces aminoglycoside uptake, preventing the toxicity, and experiments with variable calcium and amiloride concentrations suggest complementary effects between the two protectants. Elevated magnesium, in contrast, does not appear to significantly attenuate drug uptake, suggesting that the two divalent cations may protect hair cells from aminoglycoside damage through different mechanisms. These results provide additional evidence for calcium- and transduction-dependent aminoglycoside uptake. Divalent cations provided differential protection from neomycin and gentamicin, with high cation concentrations almost completely protecting hair cells from neomycin and acute gentamicin toxicity, but offering reduced protection from continuous (6 h) gentamicin exposure. These experiments lend further support to the hypothesis that aminoglycoside toxicity occurs via multiple pathways in a both a drug and time course-specific manner. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Coffin, Allison B.; Reinhart, Katherine E.; Owens, Kelly N.; Raible, David W.; Rubel, Edwin W.] Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
[Owens, Kelly N.; Raible, David W.] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA.
[Coffin, Allison B.; Reinhart, Katherine E.; Owens, Kelly N.; Rubel, Edwin W.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
RP Rubel, EW (reprint author), Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA.
EM rubel@u.washington.edu
FU NIDCD [DC000018, DC004661, DC009931, DC005987]; Virginia Merrill Bloedel
Hearing Research Center
FX Support was provided by NIDCD grants DC000018, DC004661, DC009931 and
DC005987, and the Virginia Merrill Bloedel Hearing Research Center.
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NR 98
TC 31
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 42
EP 51
DI 10.1016/j.heares.2009.03.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100005
PM 19285547
ER
PT J
AU Goble, TJ
Moller, AR
Thompson, LT
AF Goble, T. J.
Moller, A. R.
Thompson, L. T.
TI Acute high-intensity sound exposure alters responses of place cells in
hippocampus
SO HEARING RESEARCH
LA English
DT Article
DE Tinnitus; Hippocampus; Place cells; Non-classical pathways
ID COMPLEX-SPIKE CELLS; FREELY-BEHAVING RATS; INFERIOR COLLICULUS;
EVOKED-POTENTIALS; AUDITORY-CORTEX; TEMPORAL INTEGRATION; FIELD
STABILITY; NOISE EXPOSURE; SPATIAL MEMORY; UNIT-ACTIVITY
AB Overstimulation is known to activate neural plasticity in the auditory nervous system causing changes in function and re-organization. It has been shown earlier that overstimulation using high-intensity noise or tones can induce signs of tinnitus. Here we show in studies in rats that overstimulation causes changes in the way place cells of the hippocampus respond as rats search for rewards in a spatial maze. In familiar environments, a subset of hippocampal pyramidal neurons, known as place cells, respond when the animal moves through specific locations but are relatively silent in others. This place-field activity (i.e. location-specific firing) is stable in a fixed environment. The present study shows that activation of neural plasticity through overstimulation by sound can alter the response of these place cells. Rats implanted with chronic drivable dorsal hippocampal tetrodes (four microelectrodes) were assessed for stable single-unit place-field responses that were extracted from multiunit responses using NeuroExplorer computer spike-sorting software. Rats then underwent either 30 min exposure to a 4 kHz tone at 104 dB SPL or a control period in the same sound chamber. The place-field activity was significantly altered after sound exposure showing that plastic changes induced by overstimulation are not limited to the auditory nervous system but extend to other parts of the CNS, in this case to the hippocampus, a brain region often studied in the context of plasticity. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Goble, T. J.; Moller, A. R.; Thompson, L. T.] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75080 USA.
RP Thompson, LT (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci, 800 W Campbell Rd, Dallas, TX 75080 USA.
EM tres@utdallas.edu
RI Thompson, Lucien/F-3496-2012
FU American Tinnitus Association; BBS; DARPA
FX This work was supported by the grant from the American Tinnitus
Association to A.R.M. and L.T.T., a BBS initiative grant to L.T.T.,
funding from DARPA, and a precloctoral student research fellowship from
Jeffrey H. Owen to T.J.G.
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NR 52
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 52
EP 59
DI 10.1016/j.heares.2009.03.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100006
PM 19303432
ER
PT J
AU Su, YY
Luo, B
Wang, HT
Chen, L
AF Su, Yan-Yan
Luo, Bin
Wang, Hai-Tao
Chen, Lin
TI Differential effects of sodium salicylate on current-evoked firing of
pyramidal neurons and fast-spiking interneurons in slices of rat
auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Sodium salicylate; Tinnitus; Auditory cortex; Brain slice; Pyramidal
neuron; Fast-spiking interneuron; Current-evoked firing; Whole-cell
patch-clamp
ID INHIBITORY POSTSYNAPTIC CURRENTS; INDUCED TINNITUS; CEREBRAL-CORTEX;
BRAIN-SLICES; ANIMAL-MODEL; OTOTOXICITY; ACTIVATION; NEOCORTEX; ASPIRIN;
SYSTEM
AB Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effects of SS on current-evoked firing of pyramidal neurons and fast-spiking interneurons in layer II/III of auditory cortex slices in young rats (P12-P19). The two neuronal types were identified according to their characteristic patterns of current-evoked firing as recorded with whole-cell patch-clamp techniques and by their morphological features. Following perfusion of the brain slice with 1.4 mM SS, the threshold current needed to evoke an action potential remained unchanged for pyramidal neurons (68.96 +/- 10.68 pA vs 70.39 +/- 12.14 pA, n = 7, P > 0.05), but significantly increased for fast-spiking interneurons (56.9 +/- 13.69 pA vs 74.04 +/- 15.73 pA, n = 7, P < 0.05). The drug perfusion caused no significant change in current-evoked firing rates in pyramidal neurons (-2.43 +/- 7.07%, n = 14, P > 0.05); however, it drastically and reversibly depressed those in fast-spiking interneurons by up to -49.88 +/- 10.39% (n = 14, P < 0.05). Our results suggest that functionally impairing fast-spiking interneurons, which are GABAergic and inhibitory, is probably one of the pathways through which SS raises excitability in the central auditory system and consequently produces tinnitus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Su, Yan-Yan; Luo, Bin; Wang, Hai-Tao; Chen, Lin] Univ Sci & Technol China, Auditory Res Lab, Hefei 230027, Peoples R China.
[Su, Yan-Yan; Luo, Bin; Chen, Lin] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China.
[Su, Yan-Yan; Luo, Bin; Chen, Lin] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China.
RP Chen, L (reprint author), Univ Sci & Technol China, Auditory Res Lab, Hefei 230027, Peoples R China.
EM linchen@ustc.edu.cn
RI Chen, Lin/N-8327-2013
OI Chen, Lin/0000-0002-5847-2989
FU National Natural Science Foundation of China [30470560, 30730041];
National Basic Research Program of China [2006CB500803, 2007CB512306];
CAS [KSCX1-YW-R-36]
FX This study was supported by the National Natural Science Foundation of
China (Grants 30470560 and 30730041), the National Basic Research
Program of China (Grants 2006CB500803 and 2007CB512306) and the CAS
Knowledge Innovation Project (Grant KSCX1-YW-R-36).
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NR 35
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 60
EP 66
DI 10.1016/j.heares.2009.03.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100007
PM 19306920
ER
PT J
AU Schuck, JB
Smith, ME
AF Schuck, Julie B.
Smith, Michael E.
TI Cell proliferation follows acoustically-induced hair cell bundle loss in
the zebrafish saccule
SO HEARING RESEARCH
LA English
DT Article
DE Hair cell; Regeneration; Zebrafish; Saccule; Inner ear; Phalloidin; BrdU
ID AVIAN AUDITORY EPITHELIUM; VESTIBULAR OTOLITH ORGANS; SCANNING
ELECTRON-MICROSCOPY; GOLDFISH CARASSIUS-AURATUS; INTENSE SOUND EXPOSURE;
LATERAL-LINE SYSTEM; INNER-EAR; SUPPORTING CELL; CHICK COCHLEA; SENSORY
EPITHELIA
AB Fishes are capable of regenerating sensory hair cells in the inner ear after acoustic trauma. However, a time course of auditory hair cell regeneration has not been established for zebrafish. Adult zebrafish (Danio rerio) were exposed to a 100 Hz pure tone at 179 dB re 1 mu Pa RMS for 36 h and then allowed to recover for 0-14 days before morphological analysis. Hair cell bundle loss and recovery were determined using phalloidin to visualize hair bundles. Cell proliferation was quantified through bromodeoxyuridine (BrdU) labeling. Immediately following sound exposure, zebrafish saccules exhibited significant hair bundle damage (e.g., splayed, broken, and missing stereocilia) and loss (i.e., missing bundles and lesions in the epithelia) in the caudal region. Hair bundle counts increased over the course of the experiment, reaching pre-treatment levels at 14 days post-sound exposure (dpse). Low levels of proliferation were observed in untreated controls, indicating that some cells of the zebrafish saccule are mitotically active in the absence of a damaging event. In sound-exposed fish, cell proliferation peaked two dpse in the caudal region, and to a lesser extent in the rostral region. This proliferation was followed by an increase in numbers of cuticular plates with rudimentary stereocilia, and immature-like hair bundles at 7 and 14 dpse, suggesting that at least some of the saccular cell proliferation resulted in newly formed hair cells. This study establishes a time course of hair cell bundle regeneration in the zebrafish inner ear and demonstrates that cell proliferation is associated with the regenerative process. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Smith, Michael E.] Western Kentucky Univ, Dept Biol, Bowling Green, KY 42104 USA.
Western Kentucky Univ, Ctr Biotechnol, Bowling Green, KY 42104 USA.
RP Smith, ME (reprint author), Western Kentucky Univ, Dept Biol, 1906 Coll Hts Blvd 11080, Bowling Green, KY 42104 USA.
EM michael.smith1@wku.edu
FU NIH [P20 RR-16481]; NSF Kentucky EPSCoR; WKU
FX This research was supported by NIH grant P20 RR-16481, an NSF Kentucky
EPSCoR grant, and a WKU faculty summer fellowship to M.E.S.
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NR 99
TC 15
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 67
EP 76
DI 10.1016/j.heares.2009.03.008
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100008
PM 19327392
ER
PT J
AU Vlajkovic, SM
Housley, GD
Thorne, PR
Gupta, R
Enjyoji, K
Cowan, PJ
Liberman, MC
Robson, SC
AF Vlajkovic, Srdjan M.
Housley, Gary D.
Thorne, Peter R.
Gupta, Rita
Enjyoji, Keiichi
Cowan, Peter J.
Liberman, M. Charles
Robson, Simon C.
TI Preservation of cochlear function in Cd39 deficient mice
SO HEARING RESEARCH
LA English
DT Article
DE CD39; NTPDase1; Ectonucleotidase; Purinergic signalling; Knockout mice;
Hearing
ID NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE-1; RAT COCHLEA;
UP-REGULATION; CATALYTIC PROPERTIES; PROTECTION; ECTONUCLEOTIDASES;
RECEPTOR; INJURY; EXPRESSION; ADENOSINE
AB Signalling actions of extracellular nucleotides via P2 receptors influence cellular function in most tissues. In the inner ear, P2 receptor signaling is involved in many processes including the regulation of hearing sensitivity and the cochlea's response to noise stress. CD39 (NTPDase1/ENTPD1) is an ectonucleotidase (ecto-nucleoside triphosphate diphosphohydrolase) that can hydrolyse purine and pyrimidine nucleoside tri- and di-phosphates to generate monophosphate nucleosides. Mice null for Cd39 exhibit major alterations in haemostasis and profound alterations in inflammatory and thrombotic reactions. Studies in the cochlea have suggested the involvement of purinergic-type signals that could be modulated by CD39 in regulation of cochlear blood flow and also auditory neurotransmission. This study aimed to determine the auditory phenotype of adult Cd39 null mice on the C57BL6 background. Auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE) were unaffected in Cd39-deficient mice across the range of test frequencies, suggesting normal neural and outer hair cell function. Mutant mice also showed little difference to wild type mice in vulnerability to acoustic trauma. Gene expression analysis of other membrane-bound NTPDases with comparable hydrolytic activity demonstrated an up-regulation of Entpd2 and Entpd8 in the cochleae of Cd39 deficient mice. These findings suggest that Cd39 deletion alone does not adversely affect cochlear function, possibly as compensatory up-regulation of other surface located NTPDases may offset predicted alterations in cochlear homeostasis. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Vlajkovic, Srdjan M.; Housley, Gary D.; Thorne, Peter R.; Gupta, Rita] Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, Auckland 1142, New Zealand.
[Thorne, Peter R.] Univ Auckland, Fac Med & Hlth Sci, Discipline Audiol, Auckland 1142, New Zealand.
[Enjyoji, Keiichi; Robson, Simon C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Cowan, Peter J.] Univ Melbourne, St Vincents Hosp Melbourne, Immunol Res Ctr, Melbourne, Vic, Australia.
[Cowan, Peter J.] Univ Melbourne, Dept Med, Melbourne, Vic, Australia.
[Liberman, M. Charles] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
RP Vlajkovic, SM (reprint author), Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, 85 Pk Rd,Private Bag 92019, Auckland 1142, New Zealand.
EM s.vlajkovic@auckland.ac.nz; g.housley@unsw.edu.au;
pr.thorne@auckland.ac.nz; r.gupta@aucklan-d.ac.nz;
kenjoji@caregroup.harvard.edu; Peter.COWAN@svh-m.org.au;
Charles_Liberman@meei.harvard.edu; srobson@bidmc.harvard.edu
FU Health Research Council (NZ); Deafness Research Foundation (NZ);
Auckland Medical Research Foundation; National Institute on Deafness and
other Communicative Disorders [DC RO1 00188]; RNID
FX This study was supported by the Health Research Council (NZ), Deafness
Research Foundation (NZ), Auckland Medical Research Foundation, the
National Institute on Deafness and other Communicative Disorders (DC RO1
00188 to MCQ, and RNID (UK).
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NR 35
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 77
EP 82
DI 10.1016/j.heares.2009.03.009
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100009
PM 19327391
ER
PT J
AU Rosowski, JJ
Cheng, JT
Ravicz, ME
Hulli, N
Hernandez-Montes, M
Harrington, E
Furlong, C
AF Rosowski, John J.
Cheng, Jeffrey Tao
Ravicz, Michael E.
Hulli, Nesim
Hernandez-Montes, Maria
Harrington, Ellery
Furlong, Cosme
TI Computer-assisted time-averaged holograms of the motion of the surface
of the mammalian tympanic membrane with sound stimuli of 0.4-25 kHz
SO HEARING RESEARCH
LA English
DT Article
DE Tympanic membrane; Middle-ear sound transmission; Middle-ear models
ID HUMAN MIDDLE-EAR; FINITE-ELEMENT METHOD; VIBRATION MEASUREMENT; TEMPORAL
BONES; CAT EARDRUM; MODEL; TRANSMISSION; GERBIL; MECHANICS
AB Time-averaged holograms describing the sound-induced motion of the tympanic membrane (TM) in cadaveric preparations from three mammalian species and one live ear were measured using opto-electronic holography. This technique allows rapid measurements of the magnitude of motion of the tympanic membrane surface at frequencies as high as 25 kHz. The holograms measured in response to low and middle-frequency sound stimuli are similar to previously reported time-averaged holograms. However, at higher frequencies (f > 4 kHz), our holograms reveal unique TM surface displacement patterns that consist of highly-ordered arrangements of multiple local displacement magnitude maxima, each of which is surrounded by nodal areas of low displacement magnitude. These patterns are similar to modal patterns (two-dimensional standing waves) produced by either the interaction of surface waves traveling in multiple directions or the uniform stimulation of modes of motion that are determined by the structural properties and boundary conditions of the TM. From the ratio of the displacement magnitude peaks to nodal valleys in these apparent surface waves, we estimate a Standing Wave Ratio of at least 4 that is consistent with energy reflection coefficients at the TM boundaries of at least 0.35. It is also consistent with small losses within the uniformly stimulated modal surface waves. We also estimate possible TM surface wave speeds that vary with frequency and species from 20 to 65 m/s, consistent with other estimates in the literature. The presence of standing. wave or modal phenomena has previously been intuited from measurements of TM function, but is ignored in some models of tympanic membrane function. Whether these standing waves result either from the interactions of multiple surface waves that travel along the membrane, or by uniformly excited modal displacement patterns of the entire TM surface is still to be determined. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Rosowski, John J.; Cheng, Jeffrey Tao; Ravicz, Michael E.; Furlong, Cosme] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
[Hulli, Nesim; Hernandez-Montes, Maria; Harrington, Ellery; Furlong, Cosme] Worcester Polytech Inst, Dept Mech Engn, Worcester, MA 01609 USA.
[Hulli, Nesim; Hernandez-Montes, Maria; Harrington, Ellery; Furlong, Cosme] Worcester Polytech Inst, Ctr Holog Studies & Laser MicromechaTron, Worcester, MA 01609 USA.
[Rosowski, John J.; Cheng, Jeffrey Tao; Ravicz, Michael E.; Furlong, Cosme] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Rosowski, John J.] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02139 USA.
RP Rosowski, JJ (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM john_rosowski@meei.harvard.edu
FU NIDCD; WPI; MEEI
FX This work was funded by the NIDCD, the WPI, the MEEI and a generous
donor.
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NR 53
TC 42
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 83
EP 96
DI 10.1016/j.heares.2009.03.010
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100010
PM 19328841
ER
PT J
AU Verhey, JL
Ernst, SMA
AF Verhey, Jesko L.
Ernst, Stephan M. A.
TI Comodulation masking release for regular and irregular modulators
SO HEARING RESEARCH
LA English
DT Article
DE Masking release; Modulation; Regularity; Nonlinearity
ID NARROW-BAND NOISE; AMPLITUDE-MODULATION; SIGNAL-DETECTION; QUANTITATIVE
MODEL; AUDITORY-SYSTEM; NATURAL SOUNDS; FREQUENCY; BANDWIDTH; MASKERS;
HEARING
AB The present study investigates whether the difference in comodulation masking release (CMR) for different modulator types is due to the different degrees of modulator regularity, as suggested in the literature, or results from different envelope distributions. Thresholds of a sinusoidal signal are measured in the presence of a noise masker which was either broadband or narrow band. A square-wave modulator with different degrees of regularity is used that preserves the envelope distribution. The measured CMR does not decrease as the regularity decreases. This finding argues against the hypothesis that the difference in CMR for different modulator types reported in the literature is due to differences in regularity. The data for the narrow-band conditions which either mimic the auditory frequency selectivity or preserve the modulation spectrum indicate that most of the CMR of the present study is due to within-channel cues. In agreement with this finding, within-channel models using either a peripheral nonlinearity or a modulation filterbank predict a CMR of a similar size. In contrast to the model predictions and the findings for the narrow-band conditions, the CMR for the broadband masker increases as the regularity decreases. This suggests that the CMR is not solely determined by the envelope distributions. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Verhey, Jesko L.; Ernst, Stephan M. A.] Carl VonOssietzky Univ Oldenburg, Inst Phys, D-26111 Oldenburg, Germany.
RP Verhey, JL (reprint author), Carl VonOssietzky Univ Oldenburg, Inst Phys, D-26111 Oldenburg, Germany.
EM jesko.verhey@uni-oldenburg.de
FU Deutsche Forschungsgemeinschaft [SF13 TR31]
FX This work was supported by the Deutsche Forschungsgemeinschaft (SF13
TR31) and the Heinz Neurnfiller Stiftung.
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NR 39
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 97
EP 106
DI 10.1016/j.heares.2009.03.011
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100011
PM 19341786
ER
PT J
AU Pienkowski, M
Hagerman, B
AF Pienkowski, Martin
Hagerman, Bjorn
TI Auditory intensity discrimination as a function of level-rove and tone
duration in normal-hearing and impaired subjects: The "mid-level hump"
revisited
SO HEARING RESEARCH
LA English
DT Article
DE Audition; Intensity discrimination; Weber's law; Cochlear compression;
Sensorineural hearing loss; Mid-level hump
ID BASILAR-MEMBRANE NONLINEARITY; SEVERE DEPARTURE; DYNAMIC-RANGE;
ROVING-LEVEL; SOUND LEVEL; TEMPORAL INTEGRATION; MOSSBAUER TECHNIQUE;
2-TONE SUPPRESSION; DIFFERENCE LIMEN; MASKING NOISE
AB The just-noticeable difference (Delta I) in the intensity (I) Of Sound is typically reported to be a constant or a slightly decreasing ratio of the baseline intensity (known as Weber's law, and the "near-miss to Weber's law", respectively). However, in the relatively few studies on the intensity discrimination of very brief sounds, Delta I/I is usually found to be non-monotonic, with poorest discrimination in the middle of the auditory dynamic range. Here, it is demonstrated that this "severe departure from Weber's law" or "mid-level hump" is not merely a phenomenon of short-duration sounds. In normal-hearing subjects (n = 8), the near-miss to Weber's law that is observed with the discrimination of 300 ms-long, 4 kHz tones, gives way to a significant mid-level hump if tone intensities are not fixed over a great many trials (as is standard practice) but are instead randomly roved, trial-to-trial, over a wide intensity range. This was not the case in subjects with mild to moderate hearing impairment (n = 4). Furthermore, in the discrimination of widely-roved, 4 ms-long, 4 kHz tone bursts, the performance of normal-hearing subjects did not significantly worsen at mid-levels compared to the unroved condition, unlike what was found with the 300 ms-long tones. It is suggested that mid-level humps could simply be the product of the well-known mid-level compressive nonlinearity in cochlear mechanics. We further suggest that the hump is eliminated, and the near-miss to Weber's law is produced, by a more central mechanism such as the recently reported "adaptation to sound-level statistics", which is bypassed during wide-range roving and possibly when sound durations are brief. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Pienkowski, Martin] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
[Pienkowski, Martin] Univ Calgary, Dept Physiol & Biophys, Calgary, AB T2N 1N4, Canada.
[Pienkowski, Martin; Hagerman, Bjorn] Karolinska Inst, Ctr Hearing & Commun Res, Lab Hearing Technol, Stockholm, Sweden.
RP Pienkowski, M (reprint author), Univ Calgary, Dept Physiol & Biophys, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM mpienkow@ucalgary.ca
RI Hagerman, Bjorn/H-6720-2014
FU Center for Hearing and Communications Research, Karolinska Institutet,
Stockholm.
FX The first author was supported by grants to Prof. Mats Ulfendahl of the
Center for Hearing and Communications Research, Karolinska Institutet,
Stockholm.
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NR 58
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 107
EP 115
DI 10.1016/j.heares.2009.03.013
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100012
PM 19345257
ER
PT J
AU Ying, YLM
Balaban, CD
AF Ying, Yu-Lan Mary
Balaban, Carey D.
TI Regional distribution of manganese superoxide dismutase 2 (Mn SOD2)
expression in rodent and primate spiral ganglion cells
SO HEARING RESEARCH
LA English
DT Article
DE Spiral ganglion cells; Manganese superoxide dismutase 2; Gradient;
Reactive oxygen species; Primate; Rodent; Superoxide dismutase;
Immunohistochemistry
ID MITOCHONDRIAL UNCOUPLING PROTEINS; AGING INNER-EAR; TEMPORAL BONE;
FREE-RADICALS; CEREBRAL-ISCHEMIA; AUDITORY-NERVE; HEARING-LOSS; RAT
COCHLEA; PRESBYCUSIS; ANTIOXIDANTS
AB Manganese superoxide dismutase 2 (SOD2) is a key metabolic anti-oxidant enzyme for detoxifying free radicals inside mitochondria. This study documents a gradient in expression of SOD2 by spiral ganglion cells in basal versus apical turn of cochlea that is consistent with differential vulnerability of high frequency hearing to free radical damage. Immurohistochemical methods were used to identify distribution of SOD2 in temporal bone sections from mice, rats, macaques, and humans. In mice and rats, both the proportion of SOD2 immunopositive type 1 spiral ganglion cells and the intensity of immunoreactivity were elevated near cochlear apex. In macaques and humans, the proportion of SO2 immunopositive spiral ganglion cells was equal across cochlear turn, but the intensity of immunoreactivity remained highest for ganglion cells near cochlear apex. Strong SOD2 immunoreactivity was also observed in human type I spiral ganglion cells. The average area density of SOD2 immunoreactivity in ganglion cells for each species and cochlear turn showed an allometric relationship with body weight, which is consistent with a conserved basal metabolic characteristic. These findings suggest that spiral ganglion cell responses to ROS exposure may vary along cochlear spiral with lower response capacity at cochlear base contributing to cumulative susceptibility to high frequency hearing loss. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ying, Yu-Lan Mary; Balaban, Carey D.] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15213 USA.
RP Ying, YLM (reprint author), Univ Pittsburgh, Dept Otolaryngol, 200 Lothrop St,Suite 500, Pittsburgh, PA 15213 USA.
EM yingym@upmc.edu; balabancd@upmc.edu
FU Pennsylvania Lions Hearing Research Foundation; American Otologic
Society
FX This project was supported by the Pennsylvania Lions Hearing Research
Foundation and American Otologic Society Research Fellowship.
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NR 47
TC 7
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL 9
PY 2009
VL 253
IS 1-2
BP 116
EP 124
DI 10.1016/j.heares.2009.04.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471SR
UT WOS:000268079100013
PM 19376215
ER
PT J
AU Hederstierna, C
Hultcrantz, M
Rosenhall, U
AF Hederstierna, Christina
Hultcrantz, Malou
Rosenhall, Ulf
TI Estrogen and hearing from a clinical point of view; characteristics of
auditory function in women with Turner syndrome
SO HEARING RESEARCH
LA English
DT Article
DE ABR; Sound localization; Speech audiometry; TEOAE
ID SPEECH RECOGNITION SCORES; PHASE AUDIOMETRY; HEAD SIZE; INNER-EAR; BETA;
POPULATION; RECEPTORS; MOUSE; NOISE; MICE
AB Turner syndrome is a chromosomal aberration affecting 1:2000 newborn girls, in which all or part of one X chromosome is absent. This leads to ovarial dysgenesis and little or no endogenous estrogen production. These women have, among many other syndromal features, a high occurrence of ear and hearing problems, and neurocognitive dysfunctions, including reduced visual-spatial abilities; it is assumed that estrogen deficiency is at least partially responsible for these problems.
In this, study 30 Turner women aged 40-67, with mild to moderate hearing loss, performed a battery of hearing tests aimed at localizing the lesion causing the sensorineural hearing impairment and assessing central auditory function, primarily sound localization.
The results of TEOAE, ABR and speech recognition scores in noise were all indicative of cochlear dysfunction as the cause of the sensorineural impairment. Phase audiometry, a test for sound localization, showed mild disturbances in the Turner women compared to the reference group, suggesting that auditory-spatial dysfunction is another facet of the recognized neurocognitive phenotype in Turner women. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Hederstierna, Christina; Hultcrantz, Malou; Rosenhall, Ulf] Karolinska Inst, Div Otorhinolaryngol & Hearing, Dept Clin Neurosci, Stockholm, Sweden.
RP Hederstierna, C (reprint author), Karolinska Inst, Div Otorhinolaryngol & Hearing, Dept Clin Neurosci, Stockholm, Sweden.
EM christina.hederstierna@karolinska.se
FU Foundation for Audiological Research (Stingerfonden); foundation Tysta
Skolan; Acta Otolaryngologica foundation
FX This study was funded by grants from the Foundation for Audiological
Research (Stingerfonden), the foundation Tysta Skolan and the Acta
Otolaryngologica foundation.
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NR 33
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 3
EP 8
DI 10.1016/j.heares.2008.11.006
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000002
PM 19095053
ER
PT J
AU Sisneros, JA
AF Sisneros, Joseph A.
TI Steroid-dependent auditory plasticity for the enhancement of acoustic
communication: Recent insights from a vocal teleost fish
SO HEARING RESEARCH
LA English
DT Article
DE Saccule; Sex steroids; Tuning; Hair cells; Inner ear
ID PLAINFIN MIDSHIPMAN FISH; PORICHTHYS-NOTATUS GIRARD; ELECTRIC FISH;
HAIR-CELLS; INNER-EAR; SIGNAL RECOGNITION; SEASONAL-VARIATION; NEURAL
MECHANISMS; ANDROGENS ALTER; MORMYRID FISH
AB The vocal plainfin midshipman fish (Porichthys notatus) has become an excellent model for identifying neural mechanisms of auditory perception that may be shared by all vertebrates. Recent neuroethological studies of the midshipman fish have yielded strong evidence for the steroid-dependent modulation of hearing sensitivity that leads to enhanced coupling of sender and receiver in this vocal-acoustic communication system. Previous work shows that non-reproductive females treated with either testosterone or 17 beta-estradiol exhibit an increase in the degree of temporal encoding by the auditory saccular afferents to the dominant frequency content of male vocalizations produced during social-reproductive behaviors. The expanded frequency sensitivity of steroid treated females mimics the reproductive female's auditory phenotype and is proposed to improve the detection and localization of calling conspecific mates during the summer breeding season. This review focuses on the novel form of steroid-dependent auditory plasticity that is found in the adult midshipman fish and its association with the reproductive biology and behavior of this species. Evidence for midshipman reproductive-state and steroid-dependent auditory plasticity is reviewed and the potential mechanisms that lead to this novel form of adaptive plasticity are discussed. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sisneros, Joseph A.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
[Sisneros, Joseph A.] Univ Washington, Dept Biol, Seattle, WA 98195 USA.
[Sisneros, Joseph A.] Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
RP Sisneros, JA (reprint author), Univ Washington, Dept Psychol, 337 Guthrie Hall,Box 351525, Seattle, WA 98195 USA.
EM sisneros@u.washington.edu
FU National Institutes of Health [1F32DC00445]; University of Washington
FX Research support for work reported here was provided by the National
Institutes of Health (1F32DC00445) and a Royal Research Fund grant from
the University of Washington.
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NR 57
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 9
EP 14
DI 10.1016/j.heares.2008.12.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000003
PM 19168118
ER
PT J
AU Arch, VS
Narins, PM
AF Arch, Victoria S.
Narins, Peter M.
TI Sexual hearing: The influence of sex hormones on acoustic communication
in frogs
SO HEARING RESEARCH
LA English
DT Article
DE Anurans; Arginine vasotocin; Auditory system; Gonadal steroids; Sensory
physiology
ID GONADOTROPIN-RELEASING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; TREEFROG
HYLA-CINEREA; FEMALE TUNGARA FROGS; ARGININE VASOTOCIN; CONCENTRATING
CELLS; AUDITORY MIDBRAIN; RANA-ESCULENTA; XENOPUS-LAEVIS; GREEN TREEFROG
AB The majority of anuran amphibians (frogs and toads) use acoustic communication to mediate sexual behavior and reproduction. Generally, females find and select their mates using acoustic cues provided by males in the form of conspicuous advertisement calls. In these species, vocal signal production and reception are intimately tied to successful reproduction. Research with anurans has demonstrated that acoustic communication is modulated by reproductive hormones, including gonadal steroids and peptide neuromodulators. Most of these studies have focused on the ways in which hormonal systems influence vocal signal production; however, here we will concentrate on a growing body of literature that examines hormonal modulation of call reception. This literature suggests that reproductive hormones contribute to the coordination of reproductive behaviors between signaler and receiver by modulating sensitivity and spectral filtering of the anuran auditory system. It has become evident that the hormonal systems that influence reproductive behaviors are highly conserved among vertebrate taxa. Thus, studying the endocrine and neuromodulatory bases of acoustic communication in frogs and toads can lead to insights of broader applicability to hormonal modulation of vertebrate sensory physiology and behavior. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Arch, Victoria S.; Narins, Peter M.] Univ Calif Los Angeles, Dept Ecol & Evolut Biol, Los Angeles, CA 90095 USA.
[Narins, Peter M.] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
RP Arch, VS (reprint author), Univ Calif Los Angeles, Dept Ecol & Evolut Biol, 621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM varch@ucla.edu; pnarins@ucla.edu
FU Paul S. Veneklasen Research Foundation; NIDCD [DC-00222]; GAANN
Fellowship
FX We are grateful to Dr. Walt Wilczynski for his insightful comments on an
earlier version of this manuscript. Financial support was provided by
grants from the Paul S. Veneklasen Research Foundation and NIDCD (No.
DC-00222) to P.M.N., and a GAANN Fellowship to V.S.A.
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NR 89
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 15
EP 20
DI 10.1016/j.heares.2009.01.001
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000004
PM 19272318
ER
PT J
AU Price, K
Zhu, XX
Guimaraes, PF
Vasilyeva, ON
Frisina, RD
AF Price, Katharine
Zhu, Xiaoxia
Guimaraes, Patricia F.
Vasilyeva, Olga N.
Frisina, Robert D.
TI Hormone replacement therapy diminishes hearing in peri-menopausal mice
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Hearing loss; Presbycusis; HRT; Otoacoustic emissions; Progestin;
Progesterone; Estrogen; Auditory brainstem response; Sex hormones
ID PRODUCT OTOACOUSTIC EMISSIONS; POSTMENOPAUSAL WOMEN; CBA MICE; ESTROGEN;
AGE; STIMULATION; ASSOCIATION; IMPAIRMENT; RESPONSES; DECLINES
AB We recently discovered that progestin in hormone replacement therapy (HRT) for post-menopausal women has detrimental effects on the ear and central auditory system [Guimaraes, P., Frisina, S.T., Mapes, F., Tadros, S.F., Frisina, D.R., Frisina, R.D., 2006. Progestin negatively affects hearing in aged women. Proc. Natl. Acad. Sci. - PNAS 103, 14246-14249]. To start determining the generality and neural bases of these human findings, the present study examined the effects of combination HRT (estrogen + progestin) and estrogen alone on hearing in peri-menopausal mice. Specifically, auditory brainstem responses (ABRs-sensitivity of the auditory system) and distortion-product otoacoustic emissions (DPOAEs-cochlear outer hair cell system) were employed. Middle age female CBA mice received either a time-release, subcutaneous implanted pellet of estrogen + progestin, estrogen alone, or placebo. Longitudinal comparisons of ABR threshold data obtained at 4 months of treatment revealed statistically significant declines in auditory sensitivity over time for the combined estrogen + progestin treatment group, with the estrogen only group revealing milder changes at 3, 6 and 32 kHz. DPOAE testing revealed statistically significant differences for the estrogen + progestin treatment group in the high and middle frequency ranges (15-29 and 30-45 kHz) after as early as 2 months of treatment (p < 0.01 and p < 0.001, respectively). Statistically significant changes were also seen at 4 months of treatment across all frequencies for the combined HRT group. These data suggest that estrogen + progestin HRT therapy of 4 months duration impairs outer hair cell functioning and overall auditory sensitivity. These findings indicate that estrogen + progestin HRT may actually accelerate age-related hearing loss, relative to estrogen monotherapy; findings that are consistent with the clinical hearing loss observed in aging women that have taken combination HRT. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Frisina, Robert D.] Univ Rochester, Med Ctr, Dept Otolaryngol, Sch Med & Dent, Rochester, NY 14642 USA.
[Zhu, Xiaoxia; Guimaraes, Patricia F.; Vasilyeva, Olga N.; Frisina, Robert D.] Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
[Frisina, Robert D.] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
[Frisina, Robert D.] Univ Rochester, Sch Med & Dent, Dept Biomed Engn, Rochester, NY 14642 USA.
RP Frisina, RD (reprint author), Univ Rochester, Med Ctr, Dept Otolaryngol, Sch Med & Dent, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM Robert_Frisina@urmc.rochester.edu
FU National Institute on Aging [NIH P01 AG09524]; National Institute on
Deafness and Other Communication Disorders [P30 DC05409]
FX We thank John Housel for technical assistance and Enza Daugherty for
project support. Supported by NIH Grant P01 AG09524 from the National
Institute on Aging, and P30 DC05409 from the National Institute on
Deafness and Other Communication Disorders.
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NR 30
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 29
EP 36
DI 10.1016/j.heares.2009.02.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000006
PM 19269311
ER
PT J
AU McFadden, D
AF McFadden, Dennis
TI Masculinization of the mammalian cochlea
SO HEARING RESEARCH
LA English
DT Article
DE Otoacoustic emissions; Auditory evoked potentials; Sex differences;
Prenatal development; Masculinization; Testosterone; Estradiol
ID SPONTANEOUS OTOACOUSTIC EMISSIONS; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; AUDITORY-EVOKED POTENTIALS; MONKEYS MACACA-MULATTA; SHEEP
OVIS-ARIES; DISTORTION-PRODUCT; SEX-DIFFERENCES; STIMULUS-FREQUENCY;
GENDER-DIFFERENCES; SPOTTED HYENAS
AB Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious explanation for several outcomes is that prenatal exposure to high levels of androgens can weaken the cochlear amplifiers and thereby weaken otoacoustic emissions (OAEs). Prenatal androgen exposure apparently also can alter auditory evoked potentials (AEPs). Some non-hormonal factors possibly capable of producing sex and group differences are discussed, and some speculations are offered about specific cochlear structures that might differ between the two sexes. (C) 2009 Elsevier B.V. All rights reserved.
C1 [McFadden, Dennis] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
[McFadden, Dennis] Univ Texas Austin, Ctr Perceptual Syst, Austin, TX 78712 USA.
RP McFadden, D (reprint author), Univ Texas Austin, Dept Psychol, Seay Bldg,1 Univ Stn,A8000, Austin, TX 78712 USA.
EM mcfadden@psy.utexas.edu
FU National Institute on Deafness and other Communication Disorders (NIDCD)
[DC 00153]
FX Supported by research Grant DC 00153 awarded by the National Institute
on Deafness and other Communication Disorders (NIDCD). E.G. Pasanen was
instrumental to the implementation and completion of all of our studies,
and he made numerous valuable comments about early drafts of this paper.
R.H. Margolis kindly provided helpful, and much appreciated, comments
about the paper. M.M. Maloney assisted with the figures.
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NR 89
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 37
EP 48
DI 10.1016/j.heares.2009.01.002
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000007
PM 19272340
ER
PT J
AU Noirot, IC
Adler, HJ
Cornil, CA
Harada, N
Dooling, RJ
Balthazart, J
Ball, GF
AF Noirot, Isabelle C.
Adler, Henry J.
Cornil, Charlotte A.
Harada, Nobuhiro
Dooling, Robert J.
Balthazart, Jacques
Ball, Gregory F.
TI Presence of aromatase and estrogen receptor alpha in the inner ear of
zebra finches
SO HEARING RESEARCH
LA English
DT Article
DE Estradiol; Steroid hormone; Basilar papilla; Hair cell; Songbird
ID AUDITORY-EVOKED-RESPONSES; HAIR CELL REGENERATION; ACOUSTIC TRAUMA;
IMMUNOCYTOCHEMICAL LOCALIZATION; IMMUNOREACTIVE CELLS;
TAENIOPYGIA-GUTTATA; SEASONAL-VARIATION; JAPANESE-QUAIL; SONGBIRD BRAIN;
MESSENGER-RNA
AB Sex differences in song behavior and in the neural system controlling song in songbirds are well documented but relatively little is known about sex differences in hearing. We recently demonstrated the existence of sex differences in auditory brainstem responses in a songbird species, the zebra finch (Taeniopygia guttata). Many sex differences are regulated by sex steroid hormone action either during ontogeny or in adulthood. As a first step to test the possible implication of sex steroids in the control of sex differences in the zebra finch auditory system, we evaluated via immunocytochemistry whether estrogens are produced and act in the zebra finch inner ear. Specifically we examined the distribution of aromatase, the enzyme converting testosterone into an estrogen, and of estrogen receptors of the alpha subtype (ER alpha) in adult zebra finch inner ears. The anatomy of the basilar papillae was visualized by fluorescein-phalloidin, which delineated the actin structure of hair cells and supporting cells at their apical surface. Whole mount preparations of basilar papillae stained by immunocytochemistry revealed in both males and females an abundant aromatase distribution in the cytoplasm of hair cells, while ER alpha was identified in the nuclei of hair cells and of underlying supporting cells. Double-labeled preparations confirmed the extensive co-localization of aromatase and ER alpha in the vast majority of the hair cells. These results are consistent with studies on non-avian species, suggesting a role for estrogens in auditory function. These findings are also consistent with the notion that estrogens may contribute to a sex difference in hearing. To our knowledge, this is the first demonstration of the presence of aromatase and of the co-localization of aromatase and ER alpha in the sensory epithelium of the inner ear in any animal model. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Cornil, Charlotte A.; Ball, Gregory F.] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA.
[Noirot, Isabelle C.; Dooling, Robert J.] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Adler, Henry J.] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Noirot, Isabelle C.] Univ Liege, Dept Sci & Environm Management, B-4000 Liege, Belgium.
[Cornil, Charlotte A.; Balthazart, Jacques] Univ Liege, Ctr Cellular & Mol Neurobiol, B-4000 Liege, Belgium.
[Harada, Nobuhiro] Fujita Hlth Univ, Sch Med, Dept Biochem, Aichi 4701192, Japan.
[Adler, Henry J.] Gallaudet Univ, Mol Genet Lab, Washington, DC 20002 USA.
RP Ball, GF (reprint author), Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA.
EM gball@jhu.edu
FU NIH/NINDS [R01 NS 35467]; NIDCD [000436]; [DC000198]; [DC001372]
FX We thank Drs Catherine E. Carr and Steven E. Brauth for generously
hosting this research. We also thank Or Elizabeth F. Brittan-Powell and
Ms Megan Shaw for the logistical assistance. This research was supported
by Grants DC000198, DC001372 to R.J.D., a Grant from the NIH/NINDS (R01
NS 35467) to G.F.B., and a disability supplement (H.J.A.) to NIDCD
000436 (Catherine E. Carr). C.A.C. is a FNRS postdoctoral researcher.
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Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 49
EP 55
DI 10.1016/j.heares.2009.04.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000008
PM 19397967
ER
PT J
AU Horner, KC
AF Horner, Kathleen C.
TI The effect of sex hormones on bone metabolism of the otic capsule - an
overview
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Hormones; Bone; Prolactin; Estrogen; Osteoprotegerin; RANK
ID KAPPA-B LIGAND/OSTEOPROTEGERIN; BRAIN-STEM RESPONSES; HEARING-LOSS;
POSTMENOPAUSAL WOMEN; RECEPTOR ACTIVATOR; MENSTRUAL-CYCLE;
ORAL-CONTRACEPTIVES; PROLACTIN SECRETION; INNER-EAR; MENIERES-DISEASE
AB Bone resorption, which can occur after the menopause, has long been considered to due to the decrease of estrogen and so estrogen and estrogen/progestin treatment in women has been employed with the aim of slowing down the process. Other important factors have recently been considered, including follicle-stimulating hormone. The hormonal control of bone metabolism has taken on a new dimension since the description, within the last decade, of a major osteoclast inhibiting control system. The receptor activator of nuclear factor-kappa B (NF-kappa B) ligand (RANKL) produced by osteoblastic lineage cells, must bind with its receptor RANK, located on osteoclasts, in order to allow the maturation and activation of osteoclasts. The potential continuous bone loss is controlled by the decoy receptor osteoprotegerin (OPG) which competitively binds to RANKL and hence blocks the interaction of RANKL-RANK. Estrogen contributes to bone protection since it decreases the response of osteoclasts to RANKL and induces osteoclast apoptosis. But estrogen, alone and especially in synergy with progesterone, is a potent stimulator of prolactin release. Prolactin affects calcium metabolism and hyperprolactinemia associated with pregnancy, lactation, antipsychotic drug treatment, or aging is reflected in decreased bone mineral density. Long-term estrogen treatment in guinea pig results in hyperprolactinemia and has been shown to lead to hearing loss as well as bone dysmorphology of the otic capsule. Recent data show that prolactin decreases OPG and increases RANKL OPG has been shown to be expressed at high levels in the cochlea and OPG knock-out mice have indeed abnormal remodeling of the otic capsule and resorption of the auditory ossicles. So estrogen-induced hyperprolactinemia could oppose estrogen protection by the knock-down of the OPG bone protection system. This might explain why oral contraception treatment and hormone replacement therapies, involving estrogen together with progestin, increases the risk of otosclerosis and vestibular disorders. Hyperprolactinemia associated with pregnancy and lactation might also underlie the association of increased risk of otosclerosis with multiple pregnancies. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Paul Cezanne, Fac Sci & Tech, Dept Physiol Neurovegetat, CRN2M,UMR 6231, F-13397 Marseille 20, France.
RP Horner, KC (reprint author), Univ Paul Cezanne, Fac Sci & Tech, Dept Physiol Neurovegetat, CRN2M,UMR 6231, Blvd Normandie Niemen, F-13397 Marseille 20, France.
EM kathleen.horner@univ-cezanne.fr
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NR 91
TC 24
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 56
EP 60
DI 10.1016/j.heares.2008.12.004
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000009
PM 19121641
ER
PT J
AU Charitidi, K
Meltser, I
Tahera, Y
Canlon, B
AF Charitidi, Konstantina
Meltser, Inna
Tahera, Yeasmin
Canlon, Barbara
TI Functional responses of estrogen receptors in the male and female
auditory system
SO HEARING RESEARCH
LA English
DT Article
DE Estrogen receptors; Hearing; Auditory; Cochlea; Hormones; Hormone
replacement therapy; Neurotrophic factors
ID GLOBAL COGNITIVE FUNCTION; HEALTH INITIATIVE MEMORY; BRAIN-STEM
RESPONSE; ALPHA ER-ALPHA; POSTMENOPAUSAL WOMEN; OTOACOUSTIC EMISSIONS;
REPLACEMENT THERAPY; RAT-BRAIN; REPRODUCTIVE PHENOTYPES; NEUROTROPHIC
FACTOR
AB Recently significant progress was made in understanding the mechanisms by which the two estrogen receptors (alpha and beta) are involved in different pathways of estrogen action in a wide variance of tissues. Divergent responses of cells and tissues to estrogens or their ligands have been attributed to various isoforms and signaling pathways of estrogen receptors. Both subtypes of estrogen receptors have been identified in the cochlea and there are indications that they have neuroprotective effects but there is still limited information on the role and specific mechanisms of these two receptors in the auditory system. This review will examine the molecular and functional actions of the two estrogen receptor subtypes, the pivotal role they play in the auditory system and their therapeutic strategies for protecting against hearing loss. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Charitidi, Konstantina; Meltser, Inna; Tahera, Yeasmin; Canlon, Barbara] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
RP Charitidi, K (reprint author), Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
EM konstantina.charitidi@ki.se
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NR 72
TC 15
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 71
EP 78
DI 10.1016/j.heares.2008.12.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000011
PM 19450435
ER
PT J
AU Miranda, JA
Wilczynski, W
AF Miranda, Jason A.
Wilczynski, Walter
TI Sex differences and androgen influences on midbrain auditory thresholds
in the green treefrog, Hyla cinerea
SO HEARING RESEARCH
LA English
DT Article
DE Sensory processing; Communication; Testosterone; Vocalization; Auditory
plasticity; Torus semicircularis
ID FROG RANA-ESCULENTA; NEOTROPICAL FROG; ACOUSTIC COMMUNICATION; ANURAN
AMPHIBIANS; NERVOUS-SYSTEM; CALL PATTERNS; FEMALE ANURAN; ELECTRIC FISH;
CRICKET FROGS; PLASTICITY
AB Reproductive hormones can modulate communication-evoked behavior by acting on neural systems associated with motivation; however, recent evidence suggests that modulation occurs at the sensory processing level as well. The anuran auditory midbrain processes communication stimuli, and is sensitive to steroid hormones. Using multiunit electrophysiology, we tested whether sex and circulating testosterone influence auditory sensitivity to pure tones and to the natural vocalization in the green treefrog, Hyla cinerea. Sex did not influence audiogram best frequencies although sexes did differ in the sensitivities at those frequencies with males more sensitive in the lower frequency range. Females were more sensitive than males in response to the natural vocalization, despite showing no difference in response to pure tones at frequencies found within the advertisement call. Thresholds to frequencies outside the range of the male advertisement call were higher in females. Additionally, circulating testosterone increased neural thresholds in females in a frequency-specific manner. These results demonstrate that sex differences are limited to frequency ranges that relate to the processing of natural vocalizations, and depend on the type of stimulus. The frequency-dependent and stimulus-dependent nature of sex and testosterone influences suggests that reproductive hormones influence the filtering properties of the auditory system. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Miranda, Jason A.; Wilczynski, Walter] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA.
RP Miranda, JA (reprint author), Emory Univ, Dept Biol, 1510 Clifton Rd,Room 2006, Atlanta, GA 30322 USA.
EM jason.miranda@emory.edu; wwilczynski@gsu.edu
RI Miranda, Jason/B-8043-2009
OI Miranda, Jason/0000-0002-1459-2022
FU NIGMS [F31 GM66547]; NIH [RO1 MH057066]
FX This research was supported by NIGMS F31 GM66547 (JAM) and NIH RO1
MH057066 (WW).
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NR 49
TC 16
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN 8
PY 2009
VL 252
IS 1-2
BP 79
EP 88
DI 10.1016/j.heares.2009.04.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 471ME
UT WOS:000268061000012
PM 19371774
ER
PT J
AU Shub, DE
Richards, VM
AF Shub, Daniel E.
Richards, Virginia M.
TI Psychophysical spectro-temporal receptive fields in an auditory task
SO HEARING RESEARCH
LA English
DT Article
DE Human; Informational-masking; Psychophysical weights
ID MULTIPLE-OBSERVATION TASKS; CORRELATION-COEFFICIENTS; INFORMATIONAL
MASKING; DECISION WEIGHTS; SIGNAL-DETECTION; INTERNAL NOISE;
REACTION-TIME; DETECTABILITY; HEARING; NEURONS
AB Psychophysical relative weighting functions, which provide information about the importance of different regions of a stimulus in forming decisions, are traditionally estimated using trial-based procedures, where a single stimulus is presented and a single response is recorded. Everyday listening is much more "free-running" in that we often must detect randomly occurring signals in the presence of a continuous background. Psychophysical relative weighting functions have not been measured with free-running paradigms. Here, we combine a free-running paradigm with the reverse correlation technique used to estimate physiological spectro-temporal receptive fields (STRFs) to generate psychophysical relative weighting functions that are analogous to physiological STRFs. The psychophysical task required the detection of a fixed target signal (a sequence of spectro-temporally coherent tone pips with a known frequency) in the presence of a continuously presented informational masker (spectro-temporally random tone pips). A comparison of psychophysical relative weighting functions estimated with the current free-running paradigm and trial-based paradigms, suggests that in informational-masking tasks subjects' decision strategies are similar in both free-running and trial-based paradigms. For more cognitively challenging tasks there may be differences in the decision strategies with free-running and trial-based paradigms. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Shub, Daniel E.; Richards, Virginia M.] Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA.
RP Shub, DE (reprint author), Univ Penn, Dept Psychol, 3451 Walnut St, Philadelphia, PA 19104 USA.
EM dshub@sas.upenn.edu
FU NIH [DC02012]
FX This research was supported by NIH DC02012 and the University of
Pennsylvania School of Arts and Sciences Cass term chair funds
(Richards). The authors thank Dr. Yi Zhou and two anonymous reviewers
for helpful comments on a previous version of this manuscript.
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Wu MCK, 2006, ANNU REV NEUROSCI, V29, P477, DOI 10.1146/annurev.neuro.29.051605.113024
NR 22
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2009.02.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300001
PM 19249339
ER
PT J
AU Job, A
Raynal, M
Kossowski, M
Studler, M
Ghernaouti, C
Baffioni-Venturi, A
Roux, A
Darolles, C
Guelorget, A
AF Job, A.
Raynal, M.
Kossowski, M.
Studler, M.
Ghernaouti, C.
Baffioni-venturi, A.
Roux, A.
Darolles, C.
Guelorget, A.
TI Otoacoustic detection of risk of early hearing loss in ears with normal
audiograms: A 3-year follow-up study
SO HEARING RESEARCH
LA English
DT Article
DE DPOAEs; Biomarkers; Noise-induced; Hearing loss; Vulnerability;
Prevention; Public health
ID EMISSION INPUT/OUTPUT FUNCTIONS; TEST-PERFORMANCE; OTITIS-MEDIA;
PHYSIOLOGICAL VULNERABILITY; GUINEA-PIG; TYMPANOMETRY; AUDIOMETRY;
HUMANS; REFLEX; ADULTS
AB Introduction: Distortion product otoacoustic emissions (DPOAEs) are known to represent the contractile amplifier function of cochlear outer hair cells. It is known that low or absent DPOAEs are associated with hearing loss on audiograms. However, low DPOAEs can also be found associated with normal audiograms. It is unknown whether low DPOAEs in normal hearing ears are risk markers for subsequent early hearing loss when subjects are exposed to noise.
Materials and methods: A 3-year follow-up study was carried out on a population of pilots aged 20-40 years (n = 521). Data collection consisted of tonal audiograms, DPOAEs measurements with a calculation of an index of abnormality (the IaDPOAE). Of the 521 pilots enrolled, 350 (67%) had follow-up data 3 years later. In pilots with normal audiograms (n = 219, all frequencies = 10 dB HL), we observed the occurrence of hearing threshold shifts after 3 years depending on whether the IaDPOAE was initially high (group 1) or low (group 2). We used this index to test the hypothesis that reduced DPOAEs levels are potential ear vulnerability biomarkers in apparent normal hearing ears.
Results: After a 3-year follow-up, the initial IaDPOAE in normal hearing subjects was correlated with final noise-induced hearing threshold shifts at high frequencies (p < 0.01). The occurrence of abnormal audiograms was significantly higher in group 1 compared to group 2 (p = 0.003). In group 1, 13% of audiograms were found with at least one frequency >= 25 dB HL compared to 3% of audiograms in group 2. In both groups, impairments occurred at high frequencies and hearing in the 4 kHz frequency range was significantly more impaired in group 1 (p = 0.035).
Group 1 was associated with a relative risk of 2.29 (95% CI 1.26-4.16, p = 0.005) of sustaining early hearing loss. There was no significant differences between groups for age and noise exposure.
Discussion: In adults with a normal audiogram, ear vulnerability to noise could be elicited by the use of objective DPOAE measurements. A high IaDPOAE that corresponded to reduced DPOAE levels constitutes a risk for early hearing loss. This study emphasised the interest of DPOAE measurements in public health and occupational noise prevention policies. The IaDPOAE calculation may also be interesting for clinicians because no DPOAE index of abnormality is currently available. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Job, A.; Baffioni-venturi, A.; Roux, A.; Darolles, C.; Guelorget, A.] CRSSA, F-38702 La Tronche, France.
[Raynal, M.; Kossowski, M.; Studler, M.; Ghernaouti, C.] Hop Instruct Armees Percy, CPEMPN, F-92141 Clamart, France.
RP Job, A (reprint author), CRSSA, 24 Ave Maquis Gresivaudan,BP 87, F-38702 La Tronche, France.
EM ajob.crssa@gmail.com
RI JOB, Agnes/L-3158-2014
OI JOB, Agnes/0000-0001-6764-284X
FU DCSSA/AST/REC [2007_RC_10]
FX Particular thanks to Pr Dan Frost for proofreading the manuscript.
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NR 37
TC 17
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 10
EP 16
DI 10.1016/j.heares.2009.02.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300002
PM 19249340
ER
PT J
AU Turcanu, D
Dalhoff, E
Muller, M
Zenner, HP
Gummer, AW
AF Turcanu, Diana
Dalhoff, Ernst
Mueller, Marcus
Zenner, Hans-Peter
Gummer, Anthony W.
TI Accuracy of velocity distortion product otoacoustic emissions for
estimating mechanically based hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE Otoacoustic emissions; Estimated DPOAE threshold; Objective hearing
threshold estimation; Differential diagnostic; Age-related hearing loss
ID AUDITORY BRAIN-STEM; PURE-TONE THRESHOLDS; MIDDLE-EAR FUNCTION; OUTER
HAIR-CELLS; GUINEA-PIGS; CLINICAL UTILITY; GROWTH-BEHAVIOR;
NERVE-FIBERS; INPUT/OUTPUT FUNCTIONS; COCHLEAR DISORDERS
AB Distortion product otoacoustic emissions (DPOAEs) measured as vibration of the human eardrum have been successfully used to estimate hearing threshold. The estimates have proved more accurate than similar methods using sound-pressure DPOAEs. Nevertheless, the estimation accuracy of the new technique might have been influenced by endogenous noise, such as heart beat, breathing and swallowing. Here, we investigate in an animal model to what extent the accuracy of the threshold estimation technique using velocity-DPOAEs might be improved by reducing noise sources.
Velocity-DPOAE I/O functions were measured in normal and hearing-impaired anaesthetized guinea pigs. Hearing loss was either conductive or induced by furosemide injection.
The estimated distortion product threshold (EDPT) obtained by extrapolation of the I/O function to the abscissa was found to linearly correlate with the compound action potential threshold at the f(2) frequency, provided that furosemide data were excluded. The standard deviation of the linear regression fit was 6 dB as opposed to 8 dB in humans, suggesting that this accuracy should be achievable in humans with appropriate improvement of signal-to-noise ratio. For the furosemide animals, the CAP threshold relative to the regression line provided an estimate of the functional loss of the inner hair cell system.
For mechanical losses in the middle ear and/or cochlear amplifier, DPOAEs measured as velocity of the umbo promise an accuracy of hearing threshold estimation comparable to classical audiometry. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Turcanu, Diana; Dalhoff, Ernst; Mueller, Marcus; Zenner, Hans-Peter; Gummer, Anthony W.] Univ Tubingen, Dept Otolaryngol, Sect Physiol Acoust & Commun, D-72076 Tubingen, Germany.
RP Gummer, AW (reprint author), Univ Tubingen, Dept Otolaryngol, Sect Physiol Acoust & Commun, Elfriede Aulhorn Str 5, D-72076 Tubingen, Germany.
EM diana.turcanu@uni-tuebingen.de; ernst.dalhoff@web.de;
marcus.mueller@uni-tuebingen.de; hans-peter.zenner@med.uni-tuebingen.de;
anthony.gummer@uni-tuebingen.de
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NR 82
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 17
EP 28
DI 10.1016/j.heares.2009.02.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300003
PM 19233253
ER
PT J
AU Bohorquez, A
Hurley, LM
AF Bohorquez, Alexander
Hurley, Laura M.
TI Activation of serotonin 3 receptors changes in vivo auditory responses
in the mouse inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
DE Serotonin; Neuromodulation; 5-HT3 receptor; Inferior colliculus
ID CENTRAL-NERVOUS-SYSTEM; FREELY MOVING CATS; 5-HT3 RECEPTORS; RAT-BRAIN;
ULTRASONIC VOCALIZATIONS; NEUROTRANSMITTER RELEASE; GABAERGIC
INHIBITION; SPECTRAL INTEGRATION; MODULATES RESPONSES;
FREQUENCY-RESPONSE
AB Metabotropic serotonin receptors such as 5-HT1A and 5-HT1B receptors shape the level, selectivity, and timing of auditory responses in the inferior colliculus (IC). Less is known about the effects of ionotropic 5-HT3 receptors, which are cation channels that depolarize neurons. In the present study, the influence of the 5-HT3 receptor on auditory responses in vivo was explored by locally iontophoresing a 5-HT3 receptor agonist and antagonists onto single neurons recorded extracellularly in mice. Three main findings emerge from these experiments. First, activation of the 5-HT3 receptor can either facilitate or suppress auditory responses, but response suppressions are not consistent with 5-HT3 effects on presynaptic GABAergic neurons. Both response facilitations and suppressions are less pronounced in neurons with high precision in response latency, suggesting functional differences in the role of receptor activation for different classes of neuron. Finally, the effects of 5-HT3 activation vary across repetition rate within a subset of single neurons, suggesting that the influence of receptor activation sometimes varies with the level of activity. These findings contribute to the view of the 5-HT3 receptor as an important component of the serotonergic infrastructure in the IC, with effects that are complex and neuron-selective. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bohorquez, Alexander; Hurley, Laura M.] Indiana Univ, Dept Biol, Ctr Integrat Study Anim Behav, Program Neurosci, Bloomington, IN 47405 USA.
RP Hurley, LM (reprint author), Indiana Univ, Dept Biol, Ctr Integrat Study Anim Behav, Program Neurosci, 1001 E 3rd St, Bloomington, IN 47405 USA.
EM lhurley@indiana.edu
FU National Institute of Deafness and Other Communication Disorders
[DC-006608]
FX The authors thank Kristin Harris for assistance in data analysis. These
experiments were funded in part by National Institute of Deafness and
Other Communication Disorders Grant DC-006608 plus supplement 02S1.
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NR 76
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 29
EP 38
DI 10.1016/j.heares.2009.02.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300004
PM 19236912
ER
PT J
AU Miko, IJ
Sanes, DH
AF Miko, Ilona J.
Sanes, Dan H.
TI Transient gain adjustment in the inferior colliculus is serotonin- and
calcium-dependent
SO HEARING RESEARCH
LA English
DT Article
DE Inferior colliculus; Synaptic plasticity; Serotonin; 5-HT(3) receptor
ID CENTRAL AUDITORY-SYSTEM; INTERAURAL PHASE DISPARITY; LATERAL SUPERIOR
OLIVE; SHORT-TERM ADAPTATION; BRAIN-STEM; RESPONSE PROPERTIES;
RECEPTIVE-FIELDS; CENTRAL NUCLEUS; 5-HT3B SUBUNIT; DORSAL NUCLEUS
AB In the inferior colliculus (IC) a brief period of acoustic conditioning can transiently enhance evoked discharge rate. The cellular basis of this phenomenon was assessed with whole cell current-clamp recordings in a gerbil IC brain slice preparation. The current needed to elicit a single action potential was first established for each neuron. A 5s synaptic stimulus train was delivered to the lateral lemniscus (LL), and followed immediately by the initial current pulse to assess a change in postsynaptic gain. The majority of IC neurons (66%) displayed an increase in current-evoked action potentials (Positive Gain). Despite the blockade of ionotropic glutamate receptors, this effect was correlated with membrane depolarization that occurred during the synaptic train. The postsynaptic mechanism for positive gain was examined by selective blockade of specific neurotransmitter receptors. Gain in action potentials was enhanced by antagonists of metabotropic glutamate, acetylcholine, GABA(A) and glycine receptors. In contrast, the gain was blocked or reduced by an antagonist to ionotropic serotonin receptors (5-HT(3)R). Blocking voltage-activated calcium channels with verapamil also reduced the effect. These results suggest that 5-HT3R activation, coupled with increased intracellular calcium, can transiently alter postsynaptic excitability in IC neurons. (C) 2009 Elsevier B.V. All tights reserved.
C1 [Miko, Ilona J.; Sanes, Dan H.] NYU, Ctr Neural Sci, New York, NY 10003 USA.
[Sanes, Dan H.] NYU, Dept Biol, New York, NY 10003 USA.
RP Sanes, DH (reprint author), NYU, Ctr Neural Sci, 4 Washington Pl, New York, NY 10003 USA.
EM ilona@cns.nyu.edu; sanes@cns.nyu.edu
FU [DC006864]; [DC05455]
FX The authors acknowledge the technical and intellectual contributions of
Dr. Vibhakar Kotak during the course of this study. Supported by
DC006864 and DC05455.
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NR 78
TC 7
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 39
EP 50
DI 10.1016/j.heares.2009.02.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300005
PM 19232535
ER
PT J
AU Buki, B
Giraudet, F
Avan, P
AF Bueki, B.
Giraudet, F.
Avan, P.
TI Non-invasive measurements of intralabyrinthine pressure changes by
electrocochleography and otoacoustic emissions
SO HEARING RESEARCH
LA English
DT Article
DE Intralabyrinthine pressure; Posture; Otoacoustic emissions;
Electrocochleography
ID INNER-EAR PRESSURE; CEREBROSPINAL-FLUID PRESSURE; MENIERES-DISEASE;
INTRACRANIAL-PRESSURE; ENDOLYMPHATIC HYDROPS; COCHLEAR AQUEDUCT;
GUINEA-PIG; MIDDLE-EAR; EXTRATYMPANIC ELECTROCOCHLEOGRAPHY; POSTURAL
CHANGES
AB By varying the mechanical load on the stapes footplate, intralabyrinthine pressure (ILP) influences the stiffness of the middle ear and modifies its transfer function. This results in a characteristic phase shift of the otoacoustic emissions (OAEs) around 1 kHz [Buki, B., Avan, P., Lemaire, J.J., Dordain, M., Chazal, J., Ribari, O., 1996. Otoacoustic emissions: a new tool for monitoring intracranial pressure changes through stapes displacements, Hear. Res. 94, 125-139]. This finding provides non-invasive means of monitoring changes of ILP and indirectly of intracranial pressure. Yet the vulnerability of OAEs to sensorineural hearing loss excludes many patients from being monitored in this manner. Being dependent on the middle-ear transfer function, the phase of the cochlear microphonic potential (CM) around I kHz should also respond to ILP changes while being less affected by impaired hearing than OAEs. Here, normal volunteers were subjected to body tilt resulting in stepwise changes in their intracranial pressure and ILP. Their CM around 1 kHz was recorded by extratympanic electrocochleography and its dependence on body position was compared to that of distortion-product OAEs. The posture-induced CM changes were also monitored in ears with sensorineural deafness and impaired OAEs to assess the usefulness of CM in the presence of hearing impairment. Last, OAEs and CM were simultaneously monitored in gerbils during intracranial pressure changes brought about via an intracranial catheter. The phase and level shifts induced by body tilt in man and intracranial pressure changes in gerbils showed up both in distortion-product OAEs and CM with similar time courses. In normally-hearing subjects, the mean phase shifts reached 16.3 degrees for CM and 41.6 degrees for OAEs, and CM remained large enough in hearing-impaired subjects for ILP to be monitored. The ratio of about two of OAEs to CM phase shifts matched the prediction of middle-ear models allowing for the fact that CM does not travel back through the middle ear while OAEs do. It follows that CM phase around I kHz provides non-invasive access to ILP changes even if OAEs cannot be measured due to sensorineural hearing loss. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Bueki, B.; Giraudet, F.; Avan, P.] Univ Auvergne, Lab Sensory Biophys EA 2667, Sch Med, F-63000 Clermont Ferrand, France.
[Bueki, B.] Landesklinikum, ENT Dept, Krems, Austria.
RP Avan, P (reprint author), Univ Auvergne, Lab Sensory Biophys EA 2667, Sch Med, 28 Pl Henri Dunant, F-63000 Clermont Ferrand, France.
EM paul.avan@u-clermont1.fr
FU Clermont-Communaute; Region Auvergne; CNRS; INSERM
FX The technical support of Thierry Hassoun and Romain Moura is gratefully
acknowledged. Parts of this work were funded by grants from
Clermont-Communaute, the Region Auvergne (CART 2006), CNRS and INSERM
(ACI Technologies pour la Sante, 2006-7).
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NR 39
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 51
EP 59
DI 10.1016/j.heares.2009.02.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300006
PM 19233252
ER
PT J
AU Sloan, AM
Dodd, OT
Rennaker, RL
AF Sloan, Andrew M.
Dodd, Owen T.
Rennaker, Robert L., II
TI Frequency discrimination in rats measured with tone-step stimuli and
discrete pure tones
SO HEARING RESEARCH
LA English
DT Article
DE Albino rat; Frequency discrimination; Repeating standard; Tone duration;
Response latency
ID AUDITORY-FREQUENCY; INTENSITY DISCRIMINATION; DIFFERENCE LIMENS; CORTEX;
DURATION; HEARING; SENSITIVITY; THRESHOLDS; GLIDES; PITCH
AB Two modified go/no-go tasks are compared for the measurement of frequency discrimination in albino rats. The first task required detection of an instantaneous, phase-matched frequency change, called a "tone-step," within a continuous reference tone. The more traditional second task required detection of a frequency change between repetitions of a reference sequence of repeating discrete tones. For each task frequency difference limens were measured over a range of reference frequencies from 2.31 to 27.7 kHz at 60 dB sound pressure level, with both upward and downward frequency shifts. All 24 subjects quickly learned the "tone-step" task to criterion, but only 13 could also learn the discrete tone task. Subjects' performance at either task generally improved with increasing reference frequency, and in both tasks upward frequency change thresholds were significantly higher than thresholds for downward changes. Overall mean Weber ratios were 1.73 +/- 0.27% for the "tone-step" task and 2.76 +/- 0.29% for the discrete tone task. However, subjects' performance on the "tone-step" task was not correlated with subsequent performance on the discrete tone task. We suggest that the lack of correspondence between tasks might be due to frequency discrimination processes interacting with short-term memory traces during inter-tone intervals in the discrete tone task. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sloan, Andrew M.; Dodd, Owen T.; Rennaker, Robert L., II] Univ Oklahoma, Ctr Bioengn, Sarkeys Energy Ctr T 335, Norman, OK 73019 USA.
[Rennaker, Robert L., II] Univ Oklahoma, Dept Aerosp & Mech Engn, Norman, OK 73019 USA.
RP Sloan, AM (reprint author), Univ Oklahoma, Ctr Bioengn, Sarkeys Energy Ctr T 335, 100 E Boyd St, Norman, OK 73019 USA.
EM drewsloan@gmail.com; doyledodd@gmail.com; renn@ou.edu
RI Rennaker, Robert/K-9049-2013
OI Rennaker, Robert/0000-0003-1260-1973
FU National Institute of Deafness and Communicative Disorders
[F31-DC008716-01A1, 1R01DC008982]; U.S. Board of Education
FX Andrew Sloan was supported by an NRSA Fellowship from the National
Institute of Deafness and Communicative Disorders: F31-DC008716-01A1.
Owen Dodd is supported by a GAANN Fellowship from the U.S. Board of
Education. Robert Rennaker's research is supported by a grant from the
National Institute of Deafness and Communicative Disorders:
1R01DC008982.
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NR 38
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 60
EP 69
DI 10.1016/j.heares.2009.02.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300007
PM 19258029
ER
PT J
AU Kim, SJ
Park, C
Han, AL
Youn, MJ
Lee, JH
Kim, Y
Kim, ES
Kim, HJ
Kim, JK
Lee, HK
Chung, SY
So, H
Park, R
AF Kim, Se-Jin
Park, Channy
Han, A. Lum
Youn, Myung-Ja
Lee, Jeong-Han
Kim, Yunha
Kim, Eun-Sook
Kim, Hyung-Jin
Kim, Jin-Kyung
Lee, Ho-Kyun
Chung, Sang-Young
So, Hongseob
Park, Raekil
TI Ebselen attenuates cisplatin-induced ROS generation through Nrf2
activation in auditory cells
SO HEARING RESEARCH
LA English
DT Article
DE Cisplatin; Ebselen; Heme-oxygenase 1; HEI-OC1 auditory cell; Nrf2;
NAD(P)H:quinine oxidoreductase; gamma-Glutamylcysteine synthetase; Lipid
peroxidation; Organotypic culture; Auditory brainstem response (ABR)
ID INDUCED OTOTOXICITY; SELENOORGANIC ANTIOXIDANT; ORGANOTYPIC CULTURES;
PEROXIDASE-ACTIVITY; OXIDATIVE STRESS; GUINEA-PIGS; HAIR-CELLS;
IN-VITRO; PROTECTION; RATS
AB Ebselen, an organoselenium compound that acts as a glutathione peroxidase mimetic, has been demonstrated to possess antioxidant and anti-inflammatory activities. However, the molecular mechanism underlying this effect is not fully understood in auditory cells. The purpose of the present study is to investigate the protective effect of ebselen against cisplatin-induced toxicity in HEI-OC1 auditory cells, organotypic cultures of cochlear explants from two-day postnatal rats (P(2)) and adult Balb/C mice. Pretreatment with ebselen ameliorated apoptotic death induced by cisplatin in HEI-OC1 cells and organotypic cultures of Corti's organ. Ebselen pretreatment also significantly suppressed cisplatin-induced increases in intracellular reactive oxygen species (ROS), intracellular reactive nitrogen species (RNS) and lipid peroxidation levels. Ebselen dose-dependently increased the expression level of an antioxidant response element (ARE)-luciferase reporter in HEI-OC1 cells through the translocation of Nrf2 into the nucleus. Furthermore, we found that pretreatment with ebselen significantly restored Nrf2 function, whereas it ameliorated the cytotoxicity of cisplatin in cells transfectants with either a pcDNA3.1 (control) or a DN-Nrf2 (dominant-negative) plasmid. We also observed that Nrf2 activation by ebselen increased the expression of phase II antioxidant genes, including heme oxygenase (HO-1), NAD(P)H:quinine oxidoreductase, and gamma-glutamylcysteine synthetase (gamma-GCS). Treatment with ebselen resulted in an increased expression of HO-I and intranuclear Nrf2 in hair cells of organotypic cultured cochlea. After intraperitoneal injection with cisplatin, auditory brainstem responses (ABRs) threshold was measured on 8th day in Balb/C mice. ABR threshold shift was marked occurred in mice injected with cisplatin (16 mg/kg, n = 5; Click and 8-kHz stimuli, P < 0.05; 4, 16 and 32 kHz, p < 0.01), whereas that of animal group which was treated with cisplatin and ebselen was not significantly changed. These results suggest that ebselen activates the Nrf2-ARE signaling pathway, which ultimately prevents free radical stresses from cisplatin and further contributes to protect auditory sensory hair cells from free radicals produced by cisplatin. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Kim, Se-Jin; Park, Channy; Youn, Myung-Ja; Lee, Jeong-Han; Kim, Yunha; Kim, Eun-Sook; Kim, Hyung-Jin; Kim, Jin-Kyung; So, Hongseob; Park, Raekil] Wonkwang Univ, Vestibulocochlear Res Ctr VCRC, Dept Microbiol, Coll Med, Iksan 570749, Jeonbuk, South Korea.
[Lee, Ho-Kyun; Chung, Sang-Young] Chonnam Natl Univ, Dept Surg, Sch Med, Kwangju 501758, South Korea.
RP Park, R (reprint author), Wonkwang Univ, Vestibulocochlear Res Ctr VCRC, Dept Microbiol, Coll Med, 344-2 Shinyong Dong, Iksan 570749, Jeonbuk, South Korea.
EM rkpark@wku.ac.kr
FU Korea Science and Engineering Foundation (KOSEF) through the
Vestibulocochler Research Center (VCRC)
FX This work was supported by the Korea Science and Engineering Foundation
(KOSEF) through the Vestibulocochler Research Center (VCRC) at Wonkwang
University in 2008.
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NR 40
TC 30
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2009
VL 251
IS 1-2
BP 70
EP 82
DI 10.1016/j.heares.2009.03.003
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 447LT
UT WOS:000266193300008
PM 19286452
ER
PT J
AU Schmutzhard, J
Glueckert, R
Sergi, C
Schwentner, I
Abraham, I
Schrott-Fischer, A
AF Schmutzhard, Joachim
Glueckert, Rudolf
Sergi, Consolato
Schwentner, Ilona
Abraham, Irene
Schrott-Fischer, Annelies
TI Does perinatal asphyxia induce apoptosis in the inner ear?
SO HEARING RESEARCH
LA English
DT Article
DE Asphyxia; Inner ear; Apoptosis; Transmission electron microscopy;
Cleaved caspase 3; Bcl 2
ID HAIR CELL-DEATH; HEARING-LOSS; INFANTS; ACTIVATION; MECHANISMS;
CASPASES; ENCEPHALOPATHY; COCHLEA; SYSTEM; FAMILY
AB Pre- and perinatal asphyxia is known to be an important risk factor in the development of neonatal hearing impairment. This study aims to evaluate the role of apoptosis, which is known to play an essential role in the development of the inner ear structures, in the development of neonatal hearing loss caused by pre- and perinatal asphyxia.
Eight temporal bones of six different newborns were included. We performed a morphologic analysis by both light microscopy, and transmission electron microscopy, as well as immunohistochemical staining to detect the cleaved form of caspase 3 as apoptosis marker and Bcl 2 as anti-apoptotic marker.
Early and late phases of apoptosis were evidenced by condensation of chromatin (electron-dense, black structure along nuclear membrane) and fragmentation of the nucleus, respectively. Changes in nuclear morphology during apoptosis correlate with cleavage by caspase 3 located downstream of Bcl 2 action. The immunohistochemistry for cleaved caspase 3 showed a particular predilection for the inner and outer hair cells, spiral ganglion cells and the marginal cells of the stria vascularis. The brain of all examined cases did not show signs of apoptosis. In summary, this investigation suggests that apoptosis takes place before brain tissue apoptosis and is probably an earlier event than thought. Apoptosis of the cochlea is known to play an essential role in the development of the inner ear. Additionally, this study shows that apoptosis may play an important role in the development of hearing impairment, caused by pre- and perinatal asphyxia. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Schmutzhard, Joachim; Glueckert, Rudolf; Schwentner, Ilona; Abraham, Irene; Schrott-Fischer, Annelies] Innsbruck Med Univ, Dept Otorhinolaryngol, A-6020 Innsbruck, Austria.
[Sergi, Consolato] Innsbruck Med Univ, Inst Pathol, A-6020 Innsbruck, Austria.
[Sergi, Consolato] Univ Alberta, Dept Lab Med, Edmonton, AB, Canada.
RP Schwentner, I (reprint author), Innsbruck Med Univ, Dept Otorhinolaryngol, Anichstr 35, A-6020 Innsbruck, Austria.
EM Joachim.Schmutzhard@i-med.ac.at; Rudolf.Glueckert@i-med.ac.at;
Consolato.Sergi@i-med.ac.at; Ilona.Schwenter@i-med.ac.at;
Irene.Abraham@uki.at; Annelies.Schrott@i-med.ac.at
FU Austrian Science Foundation [15948-1305]
FX We are very grateful to Mrs. Gunde Rieger for the acquisition of the
photographs taken during the ultrastructural analysis. The work was
supported by the Austrian Science Foundation Grant 15948-1305.
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NR 35
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2008.12.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800001
PM 19136052
ER
PT J
AU Tanaka, C
Chen, GD
Hu, BH
Chi, LH
Li, MN
Zheng, G
Bielefeld, EC
Jamesdaniel, S
Coling, D
Henderson, D
AF Tanaka, Chiemi
Chen, Guang-Di
Hu, Bo Hua
Chi, Lai-Har
Li, Manna
Zheng, Guiliang
Bielefeld, Eric C.
Jamesdaniel, Samson
Coling, Donald
Henderson, Donald
TI The effects of acoustic environment after traumatic noise exposure on
hearing and outer hair cells
SO HEARING RESEARCH
LA English
DT Article
DE Acoustic trauma; Hearing loss; Augmented acoustic environment;
Glutathione; Chinchilla; Sound deprivation
ID STEM RESPONSE THRESHOLDS; CHINCHILLA COCHLEA; C57BL/6J MICE; DBA/2J
MICE; CONDITIONING EXPOSURES; PROLONGED EXPOSURE; HIGH-FREQUENCY;
IMPULSE NOISE; APOPTOSIS; CYTOCOCHLEOGRAMS
AB Previous studies reported that exposure to non-traumatic level sounds after traumatic noise exposure reduced the degree of noise-induced hearing loss and hair cell stereocilia damage. The current study investigated the effects of a 3-day post-noise acoustic environment on the degree of noise-induced hearing loss and cochlear damage. Female chinchillas were exposed to traumatic continuous noise (4 kHz octave-band noise) at 107 dB SPL for 1 h and then placed in either an augmented acoustic environment (AAE) or deprived acoustic environment (DAE) for 3 days. The AAE group was exposed to a broad-band noise (4-20 kHz) at 80 dB SPL and the DAE animals were fit with conventional earplugs to minimize the level of acoustic stimulation. Auditory brainstem responses (ABRs) were recorded before and 3 days after the traumatic noise exposure. The AAE group showed a significantly lower average threshold shift at the frequencies of 4 and 8 kHz (p < 0.01). Correspondingly, significantly fewer missing and dying outer hair cells (OHCs) were observed in the AAE group than in the DAE group. Although the cochlear reduced and oxidized glutathione levels (GSH and GSSG, respectively) were essentially the same in two groups at day 3, significant correlations were found between GSSG levels and mean ABR threshold shift (1-16 kHz) in the AAE group; as well as GSSG and percentage of total OHC loss in the DAE group. The results suggest that post-noise acoustic environment influenced the degree of hearing loss and OHC deterioration after traumatic noise exposure. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Tanaka, Chiemi; Chen, Guang-Di; Hu, Bo Hua; Li, Manna; Bielefeld, Eric C.; Jamesdaniel, Samson; Coling, Donald; Henderson, Donald] SUNY Buffalo, Dept Communicat Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
[Chi, Lai-Har] SUNY Buffalo, Toxicol Res Ctr, Buffalo, NY 14214 USA.
[Zheng, Guiliang] Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China.
RP Tanaka, C (reprint author), SUNY Buffalo, Dept Communicat Disorders & Sci, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM ctanaka@buffalo.edu
RI Bielefeld, Eric/D-2015-2012
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NR 28
TC 8
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 10
EP 18
DI 10.1016/j.heares.2008.12.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800002
PM 19450428
ER
PT J
AU Macias, S
Mora, EC
Kossl, M
Abel, C
Foeller, E
AF Macias, Silvio
Mora, Emanuel C.
Koessl, Manfred
Abel, Cornelius
Foeller, Elisabeth
TI The auditory cortex of the bat Molossus molossus: Disproportionate
search call frequency representation
SO HEARING RESEARCH
LA English
DT Article
DE Electrophysiological mapping; Tonotopy; Frequency tuning curves;
Cortical maps
ID MUSTACHE BAT; FUNCTIONAL-ORGANIZATION; CAROLLIA-PERSPICILLATA; INFERIOR
COLLICULUS; SENSITIVE NEURONS; RHINOLOPHUS-ROUXI; ECHOLOCATING BATS;
EPTESICUS-FUSCUS; HORSESHOE BAT; TARGET RANGE
AB The extent of the auditory cortex in the bat Molossus molossus was electrophysiologically investigated. Best frequencies and minimum thresholds of neural tuning curves were analyzed to define the topography of the auditory cortex. The auditory cortex encompasses an average cortical surface area of 5 mm(2). Characteristic frequencies are tonotopically organized with low frequencies being represented caudally and high frequencies rostrally. However, a large interindividual variability in the tonotopic organization was found. In most animals, the caudal 50% was tonotopically organized. More anterior, a variable area was found. A distinct field with reversed topography was not consistently found. Within the demarcated auditory cortex, frequencies of 30-40 kHz, which correspond to the frequency range of search calls emitted during hunting, are overrepresented, occupying 49% of the auditory cortex surface. High minimum thresholds >50 dB SPL were found in a narrow dorsal narrow area. Neurons with multipeaked tuning curves (20%) preferentially were located in the dorsal part of the auditory cortex. In accordance with studies in other bat species, the auditory cortex of M. molossus is highly sensitive to the dominant frequencies of biosonar search calls. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Macias, Silvio; Mora, Emanuel C.] Univ Havana, Fac Biol, Dept Anim & Human Biol, Vedado 10400, Cuidad Habana, Cuba.
[Koessl, Manfred; Abel, Cornelius; Foeller, Elisabeth] Univ Frankfurt, Inst Zellbiol & Neurowissensch, D-60323 Frankfurt, Germany.
RP Macias, S (reprint author), Univ Havana, Fac Biol, Dept Anim & Human Biol, Calle 25 455 Entre J&I, Vedado 10400, Cuidad Habana, Cuba.
EM silvio@fbio.uh.cu
FU VW Foundation [1/77306]; DFG
FX This work was supported by VW Foundation (1/77306) and DFG.
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NR 32
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 19
EP 26
DI 10.1016/j.heares.2009.01.006
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800003
PM 19450436
ER
PT J
AU Chung, K
Zeng, FG
AF Chung, King
Zeng, Fan-Gang
TI Using hearing aid adaptive directional microphones to enhance cochlear
implant performance
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Adaptive; Directional microphone; Hearing aid; Speech
recognition; Sound quality
ID NOISE-REDUCTION ALGORITHMS; SPEECH RECOGNITION; BACKGROUND-NOISE; SYSTEM
AB The goal of this study was to investigate whether adaptive microphone directionality could enhance cochlear implant performance. Speech stimuli were created by fitting a digital hearing aid with programmable omnidirectional (OM), fixed directional (FDM), or adaptive directional (ADM) microphones to KEMAR, and recording the hearing aid output in three noise conditions. The first condition simulated a diffused field with noise sources from five stationary locations, whereas the second and third condition represented one or three non-stationary locations in the back hemifield of KEMAR. Speech was always presented to 0 degrees azimuth and the overall signal-to-noise ratio (SNR) was +5 dB in the sound field. Eighteen postlingually deafened cochlear implant users listened to the recorded test materials via the direct audio input of their speech processors. Their speech recognition ability and overall sound quality preferences were assessed and the correlation between the amount of noise reduction and the improvement in speech recognition were calculated. The results indicated that ADM yielded significantly better speech recognition scores and overall sound quality preference than FDM and OM in all three noise conditions and the improvement in speech recognition scores was highly correlated with the amount of noise reduction. Factors influencing the noise level are discussed. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Chung, King] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47906 USA.
[Zeng, Fan-Gang] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Irvine, CA 92697 USA.
RP Chung, K (reprint author), No Illinois Univ, Dept Allied Hlth & Communicat Disorders, 323 Wirtz Hall, De Kalb, IL 60115 USA.
EM kchung@niu.edu; fzeng@uci.edu
RI Zeng, Fan-Gang/G-4875-2012
FU New Investigator Award from American Academy of Audiology; National
Institute of Health [2R01-DC002267]
FX The authors thank Lance Nelson for data collection, Rachael Fischer for
editing the testing materials, Nicholas McKibben for technical support,
and Andrea Miller for data entry. This work was supported by New
Investigator Award from American Academy of Audiology and a grant from
National Institute of Health (2R01-DC002267).
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NR 40
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 27
EP 37
DI 10.1016/j.heares.2009.01.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800004
PM 19450437
ER
PT J
AU Mom, T
Gilain, L
Avan, P
AF Mom, Thierry
Gilain, Laurent
Avan, Paul
TI Effects of glycerol intake and body tilt on otoacoustic emissions
reflect labyrinthine pressure changes in Meniere's disease
SO HEARING RESEARCH
LA English
DT Article
DE Intralabyrinthine pressure; Meniere's disease; Otoacoustic emissions;
Glycerol; Posture
ID INNER-EAR PRESSURE; EXPERIMENTAL ENDOLYMPHATIC HYDROPS; TYMPANIC
MEMBRANE DISPLACEMENT; MIDDLE-EAR; GUINEA-PIG; COCHLEAR AQUEDUCT;
DIAGNOSIS; DYNAMICS; MODEL; ELECTROCOCHLEOGRAPHY
AB It is known that by influencing stapes stiffness thus the ear's impedance, changes in intracranial and intralabyrinthine pressure induce a characteristic phase shift in otoacoustic emissions (OAE) around 1 kHz in human ears. Thus, if the regulation of pressure in intralabyrinthine compartments were abnormal in Meniere patients, OAEs might help detect it. Body tilt, which acts on intracranial pressure, and administration of an osmotically active substance provide two simple ways of manipulating intralabyrinthine pressure. Here, 14 patients with typical signs of an attack of unilateral endolymphatic hydrops were submitted to postural changes and a glycerol test. Their OAEs initially collected in upright position served as references, then OAEs were measured in supine position, and back to the upright posture one and 3 h after glycerol intake. Twenty control subjects were also tested for body tilt. The main effect of body tilt and glycerol was a phase rotation of CAEs peaking around 1 kHz. Its frequency dependence matched the one due to a pressure-related change in stapes or basilar membrane stiffness predicted by the ear model of Zwislocki (1962). The average glycerol-induced phase shifts were similar in size in Meniere vs. asymptomatic ear and audiometric thresholds were stable after glycerol intake in line with the model predicting little change in the magnitude of the transfer function. These data support a simple conductive pressure-related mechanism explaining the action of glycerol on inner ear responses. The fact that the mean postural shift was three times larger in Meniere than asymptomatic and control ears suggests an additional effect in allegedly hydropic ears. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Mom, Thierry; Gilain, Laurent; Avan, Paul] Univ Auvergne, Sch Med, Lab Sensory Biophys, F-63000 Clermont Ferrand, France.
RP Avan, P (reprint author), Univ Auvergne, Sch Med, Lab Sensory Biophys, 28 Pl Henri Dunant, F-63000 Clermont Ferrand, France.
EM paul.avan@u-clermont1.fr
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NR 57
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 38
EP 45
DI 10.1016/j.heares.2009.01.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800005
PM 19450433
ER
PT J
AU Galvin, JJ
Fu, QJ
AF Galvin, John J., III
Fu, Qian-Jie
TI Influence of stimulation rate and loudness growth on modulation
detection and intensity discrimination in cochlear implant users
SO HEARING RESEARCH
LA English
DT Article
DE Modulation detection; Intensity discrimination; Loudness growth;
Cochlear implant; High rate stimulation
ID SPEECH RECOGNITION; PHONEME RECOGNITION; PULSE-RATE; ELECTRODE
CONFIGURATION; CONSONANT RECOGNITION; AMPLITUDE-MODULATION; IMPAIRED
LISTENERS; AUDITORY-NERVE; TEMPORAL CUES; ENVELOPE CUES
AB In cochlear implants (CIs), increasing the stimulation rate typically increases the electric dynamic range (DR), mostly by reducing audibility thresholds. While CI users' intensity resolution has been shown to be fairly constant across stimulation rates, high rates have been shown to weaken modulation sensitivity, especially at low listening levels. In this study, modulation detection thresholds (MDTs) were measured in five CI users for a range of stimulation rates (250-2000 pulses per second) and modulation frequencies (5-100 Hz) at 8 stimulation levels that spanned the DR (loudness-balanced across stimulation rates). Intensity difference limens (IDLs) were measured for the same stimulation rates and levels used for modulation detection. For all modulation frequencies, modulation sensitivity was generally poorer at low levels and at higher stimulation rates. CI users were sensitive to modulation frequency only at relatively high levels. Similarly, IDLs were poorer at low levels and at high stimulation rates. When compared directly in terms of relative amplitude, IDLs were generally better than MDTs at low levels. Differences in loudness growth between dynamic and steady stimuli might explain level-dependent differences between MDTs and IDLs. The slower loudness growth associated with high stimulation rates might explain the poorer MDTs and IDLs with high rates. In general, high stimulation rates provided no advantage in intensity resolution and a disadvantage in modulation sensitivity. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Galvin, John J., III; Fu, Qian-Jie] House Ear Res Inst, Div Commun & Auditory Neurosci, Los Angeles, CA 90057 USA.
[Fu, Qian-Jie] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA.
[Fu, Qian-Jie] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA.
RP Galvin, JJ (reprint author), House Ear Res Inst, Div Commun & Auditory Neurosci, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM jgalvin@hei.org
FU NIDCD [R01-004993]
FX The authors would like to thank all the CI patients who graciously
participated in these experiments. The authors would also like to thank
Bob Shannon, Monita Chatterjee and David Landsberget, as well as two
anonymous reviewers for helpful comments. This work was supported by
NIDCD R01-004993.
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NR 39
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 46
EP 54
DI 10.1016/j.heares.2009.01.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800006
PM 19450432
ER
PT J
AU Liu, W
Bostrom, M
Kinnefors, A
Rask-Andersen, H
AF Liu, Wei
Bostrom, Marja
Kinnefors, Anders
Rask-Andersen, Helge
TI Unique expression of connexins in the human cochlea
SO HEARING RESEARCH
LA English
DT Article
DE Human cochlea; Connexin; Gap junction channel; Immunohistochemistry;
Human spiral ganglion; Speech signal processing
ID GAP-JUNCTIONS; ELECTRICAL SYNAPSES; HEARING IMPAIRMENT; MAMMALIAN BRAIN;
RAT COCHLEA; INNER-EAR; MUTATIONS; DEAFNESS; CELLS; PERMEABILITY
AB Mutations in the genes GJB2 and GJB6, which encode the proteins Connexin 26 (Cx26) and Connexin 30 (Cx30), have been linked to nonsyndromic prelingual deafness in humans. These proteins may form so-called gap junctions (GJ) or transcellular pathways between cells. The pathogenesis of deafness due to GJ Connexin mutations remains unclear partly because examinations performed in the human ear are infrequent. Here we analysed the expression and distribution of Cx26 and Cx30 in five fresh normal human cochleae taken out at occasional surgery. Immunohistochemistry including confocal microscopy in decalcified specimen showed that these proteins are widely expressed in the human cochlea. In the lateral wall there was strong antibody co-labeling for Cx26 and Cx30 that support the existence of channels comprising heteromeric Cx26/Cx30 connexons. In the organ of Corti there were some co-labeling in the supporting cell area including mainly the Claudius cells and Deiter cells of these two Cxs, apart from isolated Cx26 and Cx30 labeling in the same area, suggestive of both homomeric/homotypic pattern and hybrid pattern (heteromeric or heterotypic). Cx30, Cx26 and Connexin 36 (Cx36) immunoreactivity was also associated with spiral ganglion type I neurons, the latter being a gap junction protein specific to neurons. Gap-junction-based electrical synapses are not known to occur in mammalian auditory system other than in bats where they may play a role for fast electrical nerve transmission useful for echolocation. Their potential role in the processing of human auditory nerve signaling as well as non-GJ roles of the connexins in human cochlea is discussed. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Rask-Andersen, Helge] Univ Uppsala Hosp, Dept Surg Sci, Otolaryngol Sect, SE-75185 Uppsala, Sweden.
[Liu, Wei] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otolaryngol, Guangzhou 510275, Guangdong, Peoples R China.
RP Rask-Andersen, H (reprint author), Univ Uppsala Hosp, Dept Surg Sci, Otolaryngol Sect, SE-75185 Uppsala, Sweden.
EM helge.rask-andersen@akademiska.se
FU Tysta Skolan Foundation; Hearing Research Foundation (HRF); Sellanders
Foundation
FX Our research is a part of the European Community 6th Framework Programme
on Research, Technological Development and Demonstration
(Nanotechnology-based targeted drug delivery; Contract No.
NMP-2004-3.4.1.5-1-1; project acronym: NANOEAR). This study was
supported by grants from the Tysta Skolan Foundation, the Hearing
Research Foundation (HRF), and the Sellanders Foundation.
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NR 34
TC 16
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 55
EP 62
DI 10.1016/j.heares.2009.01.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800007
PM 19450429
ER
PT J
AU Salt, AN
Brown, DJ
Hartsock, JJ
Plontke, SK
AF Salt, Alec N.
Brown, Daniel J.
Hartsock, Jared J.
Plontke, Stefan K.
TI Displacements of the organ of Corti by gel injections into the cochlear
apex
SO HEARING RESEARCH
LA English
DT Article
DE Transduction; Operating point; Cochlea; Helicotrema
ID LOW-FREQUENCY TONES; GUINEA-PIG COCHLEA; PRODUCT OTOACOUSTIC EMISSIONS;
ACUTE ENDOLYMPHATIC HYDROPS; TRANSDUCER OPERATING POINT;
BASILAR-MEMBRANE MOTION; OUTER HAIR-CELLS; INNER-EAR; MAMMALIAN COCHLEA;
PERILYMPHATIC INJECTIONS
AB In order to transduce sounds efficiently, the stereocilia of hair cells in the organ of Corti must be positioned optimally. Mechanical displacements, such as pressure differentials across the organ caused by endolymphatic hydrops, may impair sensitivity. Studying this phenomenon has been limited by the technical difficulty of inducing sustained displacements of stereocilia in vivo. We have found that small injections (0.5-2 mu L) of Healon gel into the cochlear apex of guinea pigs produced sustained changes of endocochlear potential (EP), summating potential (SP) and transducer operating point (OP) in a manner consistent with a mechanically-induced position change of the organ of Corti in the basal turn. Induced changes immediately recovered when injection ceased. In addition, effects of low-frequency bias tones on EP, SP and OP were enhanced during the injection of gel and remained hypersensitive after injection ceased. This is thought to result from the viscous gel mechanically limiting pressure shunting through the helicotrema. Cochlear microphonics measured as frequency was varied showed enhancement below 100 Hz but most notably in the sub-auditory range. Sensitivity to low-frequency biasing was also enhanced in animals with surgically-induced endolymphatic hydrops, suggesting that obstruction of the perilymphatic space by hydrops could contribute to the pathophysiology of this condition. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Salt, Alec N.; Brown, Daniel J.; Hartsock, Jared J.] Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
[Plontke, Stefan K.] Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, D-72076 Tubingen, Germany.
[Plontke, Stefan K.] Univ Tubingen, THRC, D-72076 Tubingen, Germany.
RP Salt, AN (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA.
EM salta@msnotes.wustl.edu
FU National Institute on Deafness and Other Communication Disorders [RO1
DC01368]; National Institutes of Health; Meniere's Research Fund Group
of New South Wales, Australia
FX This study was supported by research Grant RO1 DC01368 from the National
Institute on Deafness and Other Communication Disorders, National
Institutes of Health and by a grant to Daniel Brown from the Meniere's
Research Fund Group of New South Wales, Australia. We would like to
acknowledge contribution of Ruth Gill, for assisting in the preparation
of the manuscript and of Dr. Barbara Bohne for taking the photographs of
histological specimens.
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NR 61
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2009
VL 250
IS 1-2
BP 63
EP 75
DI 10.1016/j.heares.2009.02.001
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 446XL
UT WOS:000266154800008
PM 19217935
ER
PT J
AU Ohlemiller, KK
Rice, MER
Lett, JM
Gagnon, PM
AF Ohlemiller, Kevin K.
Rice, Mary E. Rybak
Lett, Jaclynn M.
Gagnon, Patricia M.
TI Absence of strial melanin coincides with age-associated marginal cell
loss and endocochlear potential decline
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Aging; Stria vascularis; Hair cells; Spiral ganglion; Spiral
ligament; Fibrocytes; Presbycusis; C57BL/6; Mouse
ID PIGMENTED GUINEA-PIGS; INDUCED HEARING-LOSS; CHLOROQUINE-TREATED RED;
INNER-EAR; ACOUSTIC TRAUMA; SPIRAL LIGAMENT; LATERAL WALL; MICROVASCULAR
PATHOLOGY; COCHLEAR DEGENERATION; DEPENDENT DIFFERENCES
AB Cochlear stria vascularis contains melanin-producing intermediate cells that play a critical role in the production of the endocochlear potential (EP) and in maintaining the high levels of K(+) that normally exist in scala media. The melanin produced by intermediate cells can be exported to the intrastrial space, where it may be taken up by strial marginal cells and basal cells. Because melanin can act as an antioxidant and metal chelator, evidence for its role in protecting the stria and organ of Corti against noise, ototoxins, and aging has long been sought. While some evidence supports a protective role of melanin against noise and ototoxins, no evidence yet presented has demonstrated a clear role for melanin in maintaining the EP during aging. We tested this by comparing basal turn EPs and a host of cochlear cellular metrics in aging C57BL/6 (B6) mice and C57BL/6-Tyr(c-2J) mice. The latter mice carry a naturally occurring inactivating mutation of the tyrosinase locus, and produce no strial melanin. Because these two strains are coisogenic, and because pigmented B6 mice show essentially no age-related EP decline, they provide an ideal test of importance of melanin in the aging stria. Pigmented and albino B6 mice showed identical rates of hearing loss and sensory cell loss. However, after two years of age, basal turn EPs significantly diverged, with 42% of albinos showing EPs below 100 mV versus only 18% of pigmented mice. The clearest anatomical correlate of this EP difference was significantly reduced strial thickness in the albinos that was highly correlated with loss of marginal cells. Combined with findings in human temporal bones, plus recent work in BALB/c mice and gerbils, the present findings point to a common etiology in strial presbycusis whereby EP reduction is principally linked to marginal cell loss or dysfunction. For any individual, genetic background, environmental influences, and stochastic events may work together to determine whether marginal cell density or function falls below some critical level, and thus whether EP decline occurs. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Ohlemiller, Kevin K.; Lett, Jaclynn M.; Gagnon, Patricia M.] Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
[Ohlemiller, Kevin K.; Lett, Jaclynn M.; Gagnon, Patricia M.] Washington Univ, Fay & Carl Simons Ctr Biol Hearing & Deafness, Cent Inst Deaf, St Louis, MO 63110 USA.
[Ohlemiller, Kevin K.; Rice, Mary E. Rybak] Washington Univ, Program Audiol & Commun Sci, St Louis, MO 63110 USA.
RP Ohlemiller, KK (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid, St Louis, MO 63110 USA.
EM kohlemiller@wustl.edu
FU NIH [R01 DC08321, R01 DC03454, P30 DC04665]
FX Thanks to Dr. K. Hirose for helpful comments. Supported by Washington
University Med. School Dept. of Otolaryngology, NIH R01 DC08321 (KKO),
R01 DC03454 (KKO) and P30 DC04665 (R. Chole).
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NR 85
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2009
VL 249
IS 1-2
BP 1
EP 14
DI 10.1016/j.heares.2008.12.005
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 426XA
UT WOS:000264740500001
PM 19141317
ER
PT J
AU Batts, SA
Shoemaker, CR
Raphael, Y
AF Batts, Shelley A.
Shoemaker, Christopher R.
Raphael, Yehoash
TI Notch signaling and Hes labeling in the normal and drug-damaged organ of
Corti
SO HEARING RESEARCH
LA English
DT Article
DE Notch signaling; Hair cell; Supporting cell; Cochlea; Ototoxicity;
Guinea pig; bHLH gene
ID HAIR CELL REGENERATION; MAMMALIAN INNER-EAR; ACOUSTIC TRAUMA; EXPRESSION
PATTERNS; PROSENSORY PATCHES; GENE-TRANSFER; GUINEA-PIGS;
DIFFERENTIATION; COCHLEA; INHIBITION
AB During the development of the inner ear, the Notch cell signaling pathway is responsible for the specification of the pro-sensory domain and influences cell fate decisions. It is assumed that Notch signaling ends during maturity and cannot be reinitiated to alter the fate of new or existing cells in the organ of Corti. This is in contrast to non-mammalian species which reinitiate Delta1-Notch1 signaling in response to trauma in the auditory epithelium, resulting in hair cell regeneration through transdifferentiation and/or mitosis. We report immunohistochemical data and Western protein analysis showing that in the aminoglycoside-damaged guinea pig organ of Corti, there is an increase in proteins involved in Notch activation occurring within 24 h of a chemical hair cell lesion. The signaling response is characterized by the increased presence of Jagged1 ligand in pillar and Deiters cells, Notch1 signal in surviving supporting cell nuclei, and the absence of Jagged2 and Delta-like1. The pro-sensory bHLH protein Atoh1 was absent at all time points following an ototoxic lesion, while the repressor bHLH transcription factors Hes1 and Hes5 were detected in surviving supporting cell nuclei in the former inner and outer hair cell areas, respectively. Notch pathway proteins peaked at 2 weeks, decreased at 1 month, and nearly disappeared by 2 months. These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and Notch-dependent Hes activity in response to cellular trauma and that the signaling is transient. Additionally, since Hes activity antagonizes the transcription of pro-sensory Arch 1, the presence of Hes after a lesion may prohibit the occurrence of transdifferentiation in the surviving supporting cells. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Batts, Shelley A.; Raphael, Yehoash] Univ Michigan, Kresge Hearing Res Inst, Sch Med, Ann Arbor, MI 48109 USA.
[Batts, Shelley A.; Raphael, Yehoash] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA.
[Shoemaker, Christopher R.] Wayne State Univ, Sch Med, Detroit, MI USA.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, Sch Med, MSRB-3,Room 9220B,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
FU A. Alfred Taubman Medical Research Institute; Berte and Alan
Hirschfield; NIH-NIDCD [R01DC01634, R01-DC007634, T32-DC00011,
P30-DC05188]
FX This work was supported by the R. Jamison and Betty Williams
Professorship, the A. Alfred Taubman Medical Research Institute, a gift
from Berte and Alan Hirschfield and NIH-NIDCD Grants R01DC01634,
R01-DC007634, T32-DC00011, and P30-DC05188.
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NR 52
TC 29
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2009
VL 249
IS 1-2
BP 15
EP 22
DI 10.1016/j.heares.2008.12.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 426XA
UT WOS:000264740500002
PM 19185606
ER
PT J
AU McLachlan, N
AF McLachlan, Neil
TI A computational model of human pitch strength and height judgments
SO HEARING RESEARCH
LA English
DT Article
DE Pitch; Strength; Height; Neurobiological; Model
ID VENTRAL COCHLEAR NUCLEUS; PRIMARY AUDITORY-CORTEX; INFERIOR COLLICULUS;
AMPLITUDE-MODULATION; PERIODICITY INFORMATION; DIFFERENCE LIMENS;
RESPONSE AREAS; COMPUTER-MODEL; CHOPPER UNITS; COMPLEX TONES
AB A synchronization model of pitch processing was extended to include lateral inhibition mechanisms that have been observed in the mammalian mid brain, and information integration mechanisms consistent with observed changes to response fields of mammalian auditory cortex neurons. Model parameters for the inhibition mechanisms were adapted to fit model outputs to observed temporal dynamics of pitch height difference limens from the literature. Pitch strength was defined as the certainty of pitch height judgment, and was calculated by normalizing model responses by their mean. The model was adapted to fit experimental pitch strength data reported in the literature for pure tones and harmonic Complexes. It was proposed that pitch height is first estimated in relation to patterns (or templates) of tonotopic activation on the auditory nerve for particular stimulus types. These patterns are stored in long term memory. This pitch height estimation primes cortical pitch neurons to integrate finely tuned pitch information from the inferior colliculus across the periodotopic and tonotopic dimensions. Predicted pitch strength for complexes of unresolved harmonics, iterated rippled noise and amplitude modulated tones using this model also conformed to behavioral data from the literature. (C) 2009 Elsevier B.V. Ail rights reserved.
C1 Univ Melbourne, Sch Behav Sci, Melbourne, Vic 3010, Australia.
RP McLachlan, N (reprint author), Univ Melbourne, Sch Behav Sci, Melbourne, Vic 3010, Australia.
EM mcln@unimelb.edu.au
FU Australian Research Council (ARC)
FX The author would like to thank Ray Meddis and Sarah Wilson for their
generous help and advice in undertaking this research, and the reviewers
who have helped refine the manuscript. The author would also like to
acknowledge the support-of an Australian Research Council (ARC)
Discovery Grant to fund this research.
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NR 48
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2009
VL 249
IS 1-2
BP 23
EP 35
DI 10.1016/j.heares.2009.01.003
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 426XA
UT WOS:000264740500003
PM 19271312
ER
PT J
AU Fathke, RL
Gabriele, ML
AF Fathke, Robert L.
Gabriele, Mark L.
TI Patterning of multiple layered projections to the auditory midbrain
prior to experience
SO HEARING RESEARCH
LA English
DT Article
DE Inferior colliculus; Cochlear nucleus; Lateral superior olive; Dorsal
nucleus of the lateral lemniscus; Fibrodendritic laminae
ID DORSAL COCHLEAR NUCLEUS; SUPERIOR OLIVARY NUCLEUS; CAT INFERIOR
COLLICULUS; BRAIN-STEM; GANGLION-CELLS; LATERAL LEMNISCUS; AFFERENT
PATTERNS; NEURAL DEVELOPMENT; MAMMALIAN RETINA; EPH RECEPTORS
AB The precise arrangement of patterned inputs into discrete functional domains is a common organizational feature of primary sensory structures. While the specific organization of patterned connections has been well documented in the visual and somatosensory systems, comparatively little is known about the arrangement of neighboring afferent patterns in the emerging auditory system. Here we report early projection specificity for multiple converging inputs to the rat central nucleus of the inferior colliculus (ICC). Afferents arising from the dorsal cochlear nucleus (DCN), the dorsal nucleus of the lateral lemniscus (DNLL), and the lateral superior olive (LSO) establish discernible axonal layers a week prior to experience. By hearing onset, contralateral DCN and contralateral LSO layers are clearly defined and segregated from contralateral DNLL terminal zones. Layering of the ipsilateral LSO projection, on the other hand, exhibits considerable spatial overlap with the contralateral DNLL pattern. This fine laminar structure of interdigitating and overlapping inputs likely underlies the complex signal processing performed in the auditory midbrain and may serve as a model system for examining competitive interactions between neighboring excitatory and inhibitory projections early in development. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Fathke, Robert L.; Gabriele, Mark L.] James Madison Univ, Dept Biol, Harrisonburg, VA 22807 USA.
RP Gabriele, ML (reprint author), James Madison Univ, Dept Biol, MSC 7801, Harrisonburg, VA 22807 USA.
EM gabrieml@jmu.edu
FU National Science Foundation [DBI-0619207]; Jeffress Memorial Trust
[J-665]
FX This work was supported by the National Science Foundation DBI-0619207
(MLG) and the Jeffress Memorial Trust J-665 (MLG). The authors would
like to thank Dr. Thomas L. Gabriele and Sarah H. Shahmoradian for their
help and insightful comments concerning the statistical analysis of the
developing afferent patterns. RLF carried out all the experiments,
participated in the experimental design, and assisted in the editing and
writing of the manuscript. MLG conceived the project, prepared the
figures, performed the statistical analyses, and wrote the manuscript.
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NR 46
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2009
VL 249
IS 1-2
BP 36
EP 43
DI 10.1016/j.heares.2009.01.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 426XA
UT WOS:000264740500004
PM 19271271
ER
PT J
AU Vasilyeva, ON
Frisina, ST
Zhu, XX
Walton, JP
Frisina, RD
AF Vasilyeva, Olga N.
Frisina, Susan T.
Zhu, Xiaoxia
Walton, Joseph P.
Frisina, Robert D.
TI Interactions of hearing loss and diabetes mellitus in the middle age
CBA/CaJ mouse model of presbycusis
SO HEARING RESEARCH
LA English
DT Article
DE CBA/CaJ mice; Hearing loss; Diabetes; Auditory brainstem response;
Distortion product otoacoustic emissions; Auditory midbrain; Inferior
colliculus
ID PRODUCT OTOACOUSTIC EMISSIONS; HAIR-CELL LOSS; EAR DAMAGE SECONDARY;
SHR/N-CP RATS; INNER-EAR; INFERIOR COLLICULUS; AUDITORY-SYSTEM;
CONTRALATERAL SUPPRESSION; PREPULSE INHIBITION; STARTLE RESPONSE
AB Recently, we characterized the more severe nature of hearing loss in aged Type 2 diabetic human subjects [Frisina, S.T., Mapes, F., Kim, S., Frisina, D.R., Frisina, R.D., 2006. Characterization of hearing loss in aged type II diabetics. Hear. Res. 211, 103-113]. The current study prospectively assessed hearing abilities in middle age CBA/CaJ mice with Type I diabetes mellitus (T1DM) (STZ injection) or Type 2 diabetes mellitus (T2DM) (high fat diet), for a period of 6 months. Blood glucose, body weight and auditory tests (Auditory Brainstem Response-ABR, Distortion Product Otoracoustic Emissions-DPOAE) were evaluated at baseline and every 2 months. Tone and broad-band noise-burst responses in the inferior colliculus were obtained at 6 months. Body weights of controls did not change over 6 months (similar to 32 g), but there was a significant (similar to 5 g) decline in the T1DM, while T2DM exhibited similar to 10 g weight gain. Blood glucose levels significantly increased: 3-fold for T1DM, 1.3-fold for T2DM; with no significant changes in controls. ABR threshold elevations were found for both types of diabetes, but were most pronounced in the T2DM, starting as early as 2 months after induction of diabetes. A decline of mean DPOAE amplitudes was observed in both diabetic groups at high frequencies, and for the T2DM at low frequencies. In contrast to ABR thresholds, tone and noise thresholds in the inferior colliculus were lower for both diabetic groups. Induction of diabetes in middle-aged CBA/CaJ mice promotes amplification of age-related peripheral hearing loss which makes it a suitable model for studying the interaction of age-related hearing loss and diabetes. On the other hand, initial results of effects from very high blood glucose level (T1DM) on the auditory midbrain showed disruption of central inhibition, increased response synchrony or enhanced excitation in the inferior colliculus. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Vasilyeva, Olga N.; Frisina, Susan T.; Zhu, Xiaoxia; Walton, Joseph P.; Frisina, Robert D.] Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
[Walton, Joseph P.; Frisina, Robert D.] Univ Rochester, Sch Med, Dept Biomed Engn, Rochester, NY 14642 USA.
[Walton, Joseph P.; Frisina, Robert D.] Univ Rochester, Sch Med, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
[Vasilyeva, Olga N.; Frisina, Susan T.; Zhu, Xiaoxia; Walton, Joseph P.; Frisina, Robert D.] Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing Speech Res, Rochester, NY 14642 USA.
RP Frisina, RD (reprint author), Univ Rochester, Sch Med & Dent, Dept Otolaryngol, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM Robert_Frisina@urmc.rochester.edu
FU National Institute on Aging (NIH) [P01 AG09524]; National Institute on
Deafness and Communication Disorders (NIH) [P30 DC05409]
FX We thank John Housel for collecting the ABR data, and Enza Daugherty for
project assistance, and three anonymous reviewers for very helpful
critiques. This research was funded by NIH Grant P01 AG09524 from the
National Institute on Aging, and P30 DC05409 from the National Institute
on Deafness and Communication Disorders.
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NR 69
TC 11
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2009
VL 249
IS 1-2
BP 44
EP 53
DI 10.1016/j.heares.2009.01.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 426XA
UT WOS:000264740500005
PM 19271313
ER
PT J
AU Chien, W
Rosowski, JJ
Ravicz, ME
Rauch, SD
Smullen, J
Merchant, SN
AF Chien, Wade
Rosowski, John J.
Ravicz, Michael E.
Rauch, Steven D.
Smullen, Jennifer
Merchant, Saumil N.
TI Measurements of stapes velocity in live human ears
SO HEARING RESEARCH
LA English
DT Article
DE Stapes velocity; Middle-ear mechanics; Laser-Doppler vibrometry;
Middle-ear output; Umbo velocity; Round-window velocity
ID DOPPLER VIBROMETER LDV; HUMAN MIDDLE-EAR; INPUT IMMITTANCE; FOOTPLATE;
MOTION; TRANSMISSION; MECHANICS; MOVEMENT; GERBIL
AB Sound-induced stapes velocity (Vs) was measured intraoperatively in 14 patients undergoing cochlear implantation. All 14 patients had no history of middle-ear pathology, and their ossicular chains appeared normal on intraoperative inspection and palpation. The magnitude of the mean Vs (normalized by simultaneously-measured ear-canal sound pressure) was stiffness-dominated at frequencies below 1 kHz, increased up to similar to 4 kHz, and then decreased at higher frequencies. The phase of the mean velocity was +0.2 periods at 0.3 kHz, and gradually became a phase lag at higher frequencies. The mean Vs measured in this study was similar to that of seven ears reported in the only other published study of live human measurements (Huber et al., 2001). We also made measurements of Vs in fresh cadaveric temporal bones using a technique identical to that used in live ears, including similar measurement angles and location. The mean Vs measured in the cadaveric ears under these conditions was similar to the mean Vs measurements in the 14 live ears. This indicates that middle-ear mechanics are similar in live and cadaveric ears. In addition, interspecies comparisons were made between our live human Vs and the Vs reported in different animal studies. There were some clear similarities in Vs across species, as well as differences. The primary interspecies differences were in the magnitude of the Vs as well as in the frequency of transitions in the magnitudes' frequency dependence from rising to flat or falling. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Chien, Wade; Rosowski, John J.; Ravicz, Michael E.; Merchant, Saumil N.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Dept Otolaryngol, Boston, MA 02114 USA.
[Chien, Wade; Rosowski, John J.; Rauch, Steven D.; Smullen, Jennifer; Merchant, Saumil N.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Rosowski, John J.; Merchant, Saumil N.] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02139 USA.
RP Chien, W (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
EM wadechien@hotmail.com
FU NIDCD [R01 DC047998, R01 DC000194, T32 DC000020]; Silverstein Young
Investigator Award
FX We thank Diane Jones, William Peake, Jocelyn Songer, and the staff at
Eaton-Peabody Lab for their support and inputs. Funded in part by NIDCD
(grants R01 DC047998, R01 DC000194, and T32 DC000020), Mr. Axel Eliasen,
Mr. Lakshmi Mittal, and the Silverstein Young Investigator Award.
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NR 27
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2009
VL 249
IS 1-2
BP 54
EP 61
DI 10.1016/j.heares.2008.11.011
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 426XA
UT WOS:000264740500006
PM 19111599
ER
PT J
AU Cohen, LT
AF Cohen, Lawrence T.
TI Practical model description of peripheral neural excitation in cochlear
implant recipients: 5. Refractory recovery and facilitation
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Modeling of neural response; ECAP; Refractory
recovery; Facilitation; Inhibition; NRT
ID AUDITORY-NERVE FIBER; TERM ADAPTATION; RESPONSES; STIMULATION; ARRAY
AB In this paper the neural response to electrical stimulation with short inter-pulse intervals was examined. The refractory recovery of the electrically-evoked compound action potential (ECAP) was recorded using masker pulses with a wide range of currents relative to the probe pulse. The ECAP was recorded in subjects implanted with the Nucleus (R) 24 cochlear implant system (three with straight and two with Contour (TM) electrode arrays), using the Neural Response Telemetry (TM) (NRT (TM)) system. Employing the non-refractory parameters previously obtained in the fourth piper of the series and a two-parameter neural refractory recovery function, the model was fitted to ECAP recovery data for a case where the masker current was high relative to that of the probe and masking assumed to be almost complete. A single pair of refractory parameters, fitted at one probe current, allowed the model to describe quite well the ECAP recovery functions for different probe currents. Facilitatory contributions to the recovery functions, for differing current of masker relative to probe, were quantified by comparing experimental recovery functions with modeled functions that included only refractory behavior. The model should provide the means to improve speech processing algorithms for cochlear implants, by allowing the systematic incorporation of additional information concerning the neural response to electrical stimulation. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Cohen, LT (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM ltcohen@unimelb.edu.au
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NR 30
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 1
EP 14
DI 10.1016/j.heares.2008.11.007
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300001
PM 19110048
ER
PT J
AU Cohen, LT
AF Cohen, Lawrence T.
TI Practical model description of peripheral neural excitation in cochlear
implant recipients: 4. Model development at low pulse rates: General
model and application to individuals
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Modeling of neural response; ECAP; Neural survival;
Spread of neural excitation; Relative spread; NRT; Loudness growth
ID ELECTRICALLY STIMULATED COCHLEA; SENSORINEURAL HEARING-LOSS;
AUDITORY-NERVE; STOCHASTIC-MODEL; ELECTRODE ARRAY; SPATIAL SPREAD;
RESPONSES; PATTERNS; SURVIVAL; MASKING
AB This fourth paper in the series presents the initial development of the model at low pulse rates, where refractory behavior is minimal. This is a necessary developmental stage that makes possible the subsequent incorporation of temporal effects, in the fifth paper. The model comprises a population of neural fibers spread along the cochlear duct, with normally distributed thresholds. Each has a finite dynamic range, allowing stochastic behavior. The fibers are stimulated by a field that is attenuated longitudinally according to a model-based function, scaled to fit an individual FCAP (compound action potential) measure of effective field attenuation. First, the model parameters were tuned to provide general trend m itches to: the observed range of maximum comfortable level (MCL); the relationship between threshold and MCL; and the relationship between curvature of the loudness growth function and MCL. These trend differences between patients are explained by differing percentage of neural survival, although additional parameters clearly influence individual behavior, Second, the model was fitted to three electrodes in each of six subjects implanted with the Nucleus(oo) 24 cochlear implant system (three with straight and three with Contour (TM) electrode arrays). Across the subjects, different values were required for the "relative spread", a measure of neural fiber dynamic range relative to threshold, which indicated differences in neural stochasticity. The consistency of the fittings was assessed by comparing model emulations of the ECAP "spread of excitation" (SOE) measure with experimental findings. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Cohen, LT (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM ltcohen@unimelb.edu.au
FU Commonwealth of Australia; Cochlear Implant and Hearing Aid Innovation;
Department of Otolaryngology; Bionic Ear Institute
FX I acknowledge support provided by the Commonwealth of Australia through
the Co-operative Research Centre for Cochlear Implant and Hearing Aid
Innovation. I acknowledge, also, additional support provided by the
Department of Otolaryngology (University of Melbourne, Australia) and
the Bionic Ear Institute (Melbourne, Australia). Thanks are due to the
subjects, to Cochlear Limited and to the staff of the Cochlear Implant
Clinic at the Royal Victorian Eye and Ear Hospital, Melbourne, for their
assistance. I am grateful for the encouragement of Mark White. I thank
Anthony Burkitt, Barbara Cone-Wesson, Robert Cowan and Ian Jakovenko for
their critical reading of the manuscript, and acknowledge the support of
the following in reading and discussing early versions of this work:
Mark White, Richard van Hoesel and Stephen O'Leary. I am indebted to
Norbert Dillier and Waikong Lai for provision of the data of Appendix A.
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NR 41
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 15
EP 30
DI 10.1016/j.heares.2008.11.008
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300002
PM 19110049
ER
PT J
AU Praetorius, M
Brough, DE
Hsu, C
Plinkert, PK
Pfannenstiel, SC
Staecker, H
AF Praetorius, Mark
Brough, Douglas E.
Hsu, Chi
Plinkert, Peter K.
Pfannenstiel, Susanna C.
Staecker, Hinrich
TI Adenoviral vectors for improved gene delivery to the inner ear
SO HEARING RESEARCH
LA English
DT Article
DE Adenovirus vector; Enhanced delivery; Retargeting; alpha nu integrin;
Heparan sulfate; Gene therapy; Inner ear
ID PENTON BASE; FIBER; RECEPTORS; COCHLEA; CELLS; CAR; TRANSDUCTION;
EXPRESSION; INTEGRINS; BINDING
AB An important requirement for gene therapy in the inner ear is to achieve efficient gene delivery without damaging residual inner ear function. This can be achieved by delivering a high concentration of vector in a minimal volume. Adenovectors are well suited to meet these requirements since high quality concentrated vector with a high capacity for a gene payload can be produced. To reduce the number of vector particles and Volume of delivery to the inner ear, we tested vectors with enhancements in cell binding and cell entry properties. We compared delivery of a marker gene to the inner ear using two different advanced generation serotype 5 adenovector designs. The first adenovector tested, AdRGD, has a restricted tropism of entry into cells. AdRGD is an Ad5 capsid vector with an arg-gly-asp (RGD) motif built into the adenovector fiber that has also been modified to abolish the fiber-CAR and penton-integrin interactions that provide the normal well characterized two-step entry pathway for adenovirus. The AdRGD vector has enhanced binding to alpha nu integrins, The second vector, AdF2K, contains 7 lysine residues within the fiber knob and has been shown to have expanded tropism for cells in vitro and in vivo. AdF2K maintains its normal CAR and integrin receptors interactions and has an additional mechanism of entry via its ability to interact with heparan sulfate. Both vectors demonstrated effective delivery to the inner ear and more uniform labeling of the inner ear sensory epithelia than native capsid vector, when tested in vivo. Analysis of expression efficiency using quantitative PCR was tested in vitro on cultured macular organs and demonstrated that vector delivery with the AdF2K vector design yielded optimal delivery. The present study demonstrates that retargeting strategies can improve delivery to the inner ear. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Pfannenstiel, Susanna C.; Staecker, Hinrich] Univ Kansas, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66160 USA.
[Praetorius, Mark; Plinkert, Peter K.; Pfannenstiel, Susanna C.] Univ Heidelberg, Dept Otolaryngol, D-6900 Heidelberg, Germany.
[Brough, Douglas E.; Hsu, Chi] GenVec Inc, Gaithersburg, MD USA.
RP Staecker, H (reprint author), Univ Kansas, Dept Otolaryngol Head & Neck Surg, Mailstop 3010,3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM hstaecker@kumc.edu
FU National Institutes of Health [R01 DC008424]
FX Ad5 vector capsids that have undergone modification to increase binding
of heparan sulfate increase the transduction efficiency of the vector in
the inner ear, especially when low doses of vector were used. Targeting
the vector to cellular integrins resulted in a similar histologic
distribution of transgene but did not increase transgene delivery. The
AdF2K advanced generation adenovirus vector provides an advantage to
delivery of transgenes to the inner ear. Supported by National
Institutes of Health Grant R01 DC008424.
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NR 22
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 31
EP 38
DI 10.1016/j.heares.2008.11.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300003
PM 19105978
ER
PT J
AU Chen, GD
Li, MN
Tanaka, C
Bielefeld, EC
Hu, BH
Kermany, MH
Salvi, R
Henderson, D
AF Chen, Guang-Di
Li, Manna
Tanaka, Chiemi
Bielefeld, Eric C.
Hu, Bo-Hua
Kermany, Mohammad Habiby
Salvi, Richard
Henderson, Donald
TI Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: Function
and morphology
SO HEARING RESEARCH
LA English
DT Article
DE OHC; Age-related hearing loss; Prestin; Fischer 344 rat
ID AGE-RELATED-CHANGES; MOTOR PROTEIN; HEARING-LOSS;
SUCCINIC-DEHYDROGENASE; PRESTIN; PATHOLOGY; DEGENERATION; PRESBYCUSIS;
EXPRESSION; THRESHOLD
AB As previously reported [Popelar, J., Groh, D., Pelanova, J., Canlon, B., Syka, J., 2006. Age-related changes in cochlear and brainstern auditory functions in Fischer 344 rats. Neurobiol. Aging 27, 490-500; Buckiova, D., Popelar, J., Syka, J., 2007. Aging cochleas in the F344 rat: morphological and functional changes. Exp. Gerontol. 42, 629-638; Bielefeld, E.C., Coling, D., Chen, G.D., Li, M.N., Tanaka, C., Hu, B.H., Henderson, D., 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear. Res. 241, 26-33], aged Fischer 344 (17344) rats with severe hearing loss retain many outer hair cells (OHCs) especially in the middle turn of the cochlea. The current Study confirmed the previous findings showing that aged OHCs were present, but dysfunctional. Distortion product otoacoustic emissions (DPOAE), which are believed to reflect in vivo OHC motility, were absent in the aged rats while the majority of OHCs (>80%) were present and morphologically intact. There was no detectable injury of OHC stereocilia as assessed by actin-staining and examination under the light microscope. Cochlear microphonics (CM) at 12 kHz, recorded from the middle turn, only showed a slight age-related reduction, indicating a normal mechanoelectrical transduction apparatus in the remaining OHCs in the cochlear regions with 10-20% OHC loss. Activities of succinate dehydrogenase (SDH), an enzyme shared by the citric acid cycle and the mitochondrial electron transport chain (METC), were also at normal levels in aged OHCs. Importantly, aged OHCs showed reduced levels of prestin immunolabeling compared to young controls. Together with our previous finding showing that the stria vascularis and endocochlear potential were essentially normal in aged F344 rats [Bielefeld, E.C., Coling, D., Chen, G.D., Li, M.N., Tanaka, C., Hu, B.H., Henderson, D., 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear. Res. 241, 26-33], the results Suggest that disruption of prestin is the major cause of DPOAE loss and loss of cochlear sensitivity. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Chen, Guang-Di; Li, Manna; Tanaka, Chiemi; Bielefeld, Eric C.; Hu, Bo-Hua; Kermany, Mohammad Habiby; Salvi, Richard; Henderson, Donald] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Chen, GD (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main, Buffalo, NY 14214 USA.
EM gchen7@buffalo.edu
RI Bielefeld, Eric/D-2015-2012
FU NIH [1RO1DCO0686201AI]
FX This study was supported by the NIH Grant: #1RO1DCO0686201AI to Donald
Henderson. Part of the results have been presented at the 2008 ARO
Midwinter meeting in Phoenix, AZ (Chen et al., 2008, #645).
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NR 41
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 39
EP 47
DI 10.1016/j.heares.2008.11.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300004
PM 19111601
ER
PT J
AU Ross, B
Tremblay, K
AF Ross, Bernhard
Tremblay, Kelly
TI Stimulus experience modifies auditory neuromagnetic responses in young
and older listeners
SO HEARING RESEARCH
LA English
DT Article
DE Hearing; Auditory plasticity; Perceptual learning; Aging; MEG
ID EVENT-RELATED POTENTIALS; SYNTHETIC-APERTURE MAGNETOMETRY; TEST-RETEST
RELIABILITY; STEADY-STATE RESPONSES; EVOKED-POTENTIALS; SPEECH SOUNDS;
TIME-COURSE; CORTEX; PLASTICITY; MUSICIANS
AB Experiencing repeatedly presented auditory stimuli during magnetoencephalographic (MEG) recording may affect how the sound is processed in the listener's brain and may modify auditory evoked responses over the time course of the experiment. Amplitudes of NI and P2 responses have been proposed as indicators for the outcome of training and learning studies. In this context the effect of merely sound experience on N1 and P2 responses was studied during two experimental sessions on different days with young, middle-aged, and older participants passively listening to speech stimuli and a noise sound. NI and P2 were characterized as functionally distinct responses with P2 sources located more anterior than NI in auditory cortices. N1 amplitudes decreased continuously during each recording session, but completely recovered between sessions. In contrast, P2 amplitudes were fairly constant within a session but increased from the first to the second day of MEG recording. Whereas NI decrease was independent of age, the amount of P2 amplitude increase diminished with age. Temporal dynamics of N1 and P2 amplitudes were interpreted as reflecting neuroplastic changes along different time scales. The long lasting increase in P2 amplitude indicates that the auditory P2 response is potentially an important physiological correlate of perceptual learning, memory, and training. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Ross, Bernhard] Rotman Res Inst, Baycrest Ctr, Toronto, ON M6A 2E1, Canada.
[Ross, Bernhard] Univ Toronto, Toronto, ON M6A 2E1, Canada.
[Tremblay, Kelly] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
RP Ross, B (reprint author), Rotman Res Inst, Baycrest Ctr, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada.
EM bross@rotman-baycrest.on.ca
FU Canadian Institutes for Health Research [81135]; National Institutes of
Health [NIDCD R01 DC007705]; Virginia Merrill Bloedel Hearing Research
Center
FX We are grateful for support by grants from the Canadian Institutes for
Health Research (Grant No. 81135) to BR and the National Institutes of
Health (NIH NIDCD R01 DC007705) awarded to KT as well as the Virginia
Merrill Bloedel Hearing Research Center traveling scholar program for
KT. We like to thank Drs. Claude Alain and Terry Picton for helpful
comments on a previous version of the manuscript.
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NR 63
TC 44
Z9 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 48
EP 59
DI 10.1016/j.heares.2008.11.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300005
PM 19110047
ER
PT J
AU Kolarik, AJ
Culling, JF
AF Kolarik, Andrew J.
Culling, John F.
TI Measurement of the binaural temporal window using a lateralisation task
SO HEARING RESEARCH
LA English
DT Article
DE Binaural hearing; Temporal resolution; Lateralisation
ID INTER-AURAL CORRELATION; CORRELATION DISCRIMINATION; INTENSITY
DIFFERENCES; BAND NOISE; TIME; DETECTABILITY; LEVEL; TONE; SLUGGISHNESS;
FREQUENCY
AB Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 21-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024 mu s were applied to brief probe noises. These probes, with durations of 16 to 362 ms, were placed symmetrically in time within a 500-ms burst of otherwise interaurally uncorrelated noise. Psychometric functions were measured to obtain thresholds and temporal windows fitted to those thresholds. The best-fitting window was a symmetric roex shape (equivalent rectangular duration = 197 ms), an order of magnitude longer than monaural temporal windows and differed substantially from windows reported by Bernstein et al. [Bernstein, L.R., Trahiotis, C., Akeroyd, M.A., Hartung, K., 2001. Sensitivity to brief changes of interaural time and interaural intensity. J. Acoust. Soc. Am. 109, 1604-1615]. Experiment 2, replicated their main experiment, comparing their ITD-detection task with a similar discrimination procedure. Thresholds in the detection conditions were significantly better than those in the discrimination condition, particularly for short probe durations, indicating the use of an additional cue at these durations for the detection task and thus undermining the assumptions made in their window fit. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Kolarik, Andrew J.; Culling, John F.] Cardiff Univ, Sch Psychol, Cardiff CF10 3AT, S Glam, Wales.
RP Culling, JF (reprint author), Cardiff Univ, Sch Psychol, Tower Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales.
EM Cullingj@cf.ac.uk
RI Culling, John/D-1468-2009
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NR 29
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 60
EP 68
DI 10.1016/j.heares.2008.12.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300006
PM 19111600
ER
PT J
AU Reuss, S
Kuhn, I
Windoffer, R
Riemann, R
AF Reuss, Stefan
Kuehn, Inna
Windoffer, Reinhard
Riemann, Randolf
TI Neurochemistry of identified motoneurons of the tensor tympani muscle in
rat middle ear
SO HEARING RESEARCH
LA English
DT Article
DE Nitric oxide synthase; Neuropeptides; Fluoro-Gold; Retrograde tracing
ID NITRIC-OXIDE SYNTHASE; SUPERIOR OLIVARY COMPLEX; LOWER BRAIN-STEM;
RETROGRADE HORSERADISH-PEROXIDASE; IMMUNOREACTIVE CELL-BODIES;
TRIGEMINAL MOTOR NUCLEUS; CENTRAL NERVOUS-SYSTEM; GUINEA-PIG;
SUBSTANCE-P; CHOLINE-ACETYLTRANSFERASE
AB The objective of the present study was to identify efferent and afferent transmitters of motoneurons of the tensor tympani Muscle (MoTTM) to gain more insight into the neuronal regulation of the muscle. To identify MoTTM, we injected the fluorescent neuronal tracer Fluoro-Gold (FG) into the muscle after preparation of the middle ear in adult rats. Upon terminal uptake and retrograde neuronal transport, we observed FG in neurons located lateral and ventrolateral to the motor trigeminal nucleus ipsilateril to the injection site. Immunohistochemical studies of these motoneurons showed that apparently all contained choline acetyltransferase, demonstrating their motoneuronal character. Different portions of these cell bodies were immunoreactive to bombesin (33%), cholecystokinin (37%), endorphin (100%), leuenkephalin (25%) or neuronal nitric oxide synthase (32%). MoTTM containing calcitonin gene-related peptide, tyrosine hydroxylase, substance P, neuropeptide Y or serotonin were not found. While calcitonin gene-related peptide was not detected in the region under study, nerve fibers immunoreactive to tyrosine hydroxylase, substance P, neuropeptide Y or serotonin were observed in close spatial relationship to MoTTM, suggesting that these neurons are under aminergic and neuropeptidergic influence. Our results demonstrating the neurochemistry of motoneuron input and output of the rat tensor tympany muscle may prove useful also for the general understanding of motoneuron function and regulation. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Reuss, Stefan; Kuehn, Inna; Windoffer, Reinhard] Johannes Gutenberg Univ Mainz, Dept Anat & Cell Biol, Sch Med, D-55099 Mainz, Germany.
[Riemann, Randolf] City Hosp Frankfurt Hoechst, Dept Otorhinolaryngol, Frankfurt, Germany.
RP Reuss, S (reprint author), Johannes Gutenberg Univ Mainz, Dept Anat & Cell Biol, Sch Med, Becherweg 13, D-55099 Mainz, Germany.
EM reuss@uni-mainz.de
FU Deutsche Forschungsgerneinschaft [Re 644/3-1]; University Medical
Faculty Science Program (MAIFOR); Schleicher-Stiftung (Baden-Baden)
FX The authors thank U. Disque-Kaiser for excellent technical assistance.
Data in this study are part of a thesis presented by 1. Kuhn in partial
fulfillment of her M.D. degree at the Johannes Gutenberg-University,
Mainz. This work was supported by the Deutsche Forschungsgerneinschaft
(Re 644/3-1), the University Medical Faculty Science Program (MAIFOR)
and the Schleicher-Stiftung (Baden-Baden).
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NR 73
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2009
VL 248
IS 1-2
BP 69
EP 79
DI 10.1016/j.heares.2008.12.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 419QM
UT WOS:000264234300007
PM 19126425
ER
PT J
AU Cohen, LT
AF Cohen, Lawrence T.
TI Practical model description of peripheral neural excitation in cochlear
implant recipients: 1. Growth of loudness and ECAP amplitude with
current
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Modeling of neural response; ECAP; NRT; Loudness
growth; Temporal loudness summation
ID STIMULATED AUDITORY-NERVE; ELECTRODE ARRAYS; STOCHASTIC-MODEL; SPATIAL
SPREAD; MASKING; CONTOUR(TM)
AB This is the first in a series of five papers, presenting the development of a practical mathematical model that describes excitation of the auditory nerve by electrical stimulation from a cochlear implant. Here are presented methods and basic data for the subjects, who were implanted with the Nucleus' 24 cochlear implant system (three with straight and three with Contour (TM) electrode arrays), required as background for all papers. The growth of subjective loudness with stimulus current was studied, for low-rate pulse bursts and for single pulses. The growth of the amplitude of the compound action potential (ECAP) was recorded using the Neural Response Telemetry (TM) (NRT (TM)) system. An approximately linear relationship was demonstrated between ECAP amplitude and burst loudness, although this failed at the lower end of the dynamic range, to an extent that varied with subject and stimulated electrode. Single-pulse stimuli were audible below ECAP threshold, demonstrating that the audibility of burst stimuli at such low currents was not due solely to temporal loudness summation. An approximate function was established relating the curvature of the burst loudness growth function to the maximum comfortable level (MCL). Loudness at threshold was quantified, as a percentage of loudness at MCL. The relationship between loudness and ECAP growth functions, the curvature versus MCL function and the loudness associated with threshold are relevant to the development of a mathematical model of electrically evoked auditory nerve excitation. (c) 2008 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Cohen, LT (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM ltcohen@unimelb.edu.au
FU Commonwealth of Australia through the Co-operative Research Centre for
Cochlear Implant and Hearing Aid Innovation; Department of
Otolaryngology (University of Melbourne, Australia); Bionic Ear
Institute (Melbourne, Australia).
FX I acknowledge support provided by the Commonwealth of Australia through
the Co-operative Research Centre for Cochlear Implant and Hearing Aid
Innovation. I acknowledge, also, additional support provided by the
Department of Otolaryngology (University of Melbourne, Australia) and
the Bionic Ear Institute (Melbourne, Australia). Thanks are due to the
subjects, to Cochlear Limited and to the staff of the Cochlear Implant
Clinic at the Royal Victorian Eye and Ear Hospital, Melbourne, for their
assistance. I am grateful for the encouragement of Mark White. I thank
Anthony Burkitt, David Grayden, Barbara Cone-Wesson, Robert Cowan and
Ian Jakovenko for their critical reading of the manuscript, and
acknowledge the support of the following in reading and discussing early
versions of this work: Mark White, Richard van Hoesel and Stephen
O'Leary.
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NR 34
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN 20
PY 2009
VL 247
IS 2
BP 87
EP 99
DI 10.1016/j.heares.2008.11.003
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 412GZ
UT WOS:000263714500001
PM 19063956
ER
PT J
AU Cohen, LT
AF Cohen, Lawrence T.
TI Practical model description of peripheral neural excitation in cochlear
implant recipients: 2. Spread of the effective stimulation field (ESF),
from ECAP and FEA
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Modeling of neural response; ECAP; NRT; Current
spread; Spread of neural excitation
ID NERVE; ARRAY
AB This second paper of the series considers the spread of the "effective stimulation field" (ESF) produced by monopolar biphasic stimulation of an electrode within scala tympani, in subjects implanted with the Nucleus' 24 cochlear implant system (three with straight and two with Contour (TM) electrode arrays). A novel measure of the ECAP was employed, using the Neural Response Telemetry (TM) (NRT (TM)) system. The ESF provides a patient-specific measure of the "ability" of the stimulation field to excite neurons at differing locations around the cochlea. The results were interpreted with the aid of simple finite element computational models of the electric field. The finite element models were used to generate template field spread functions that differed with radial distance of the stimulated electrode from the modiolus. Relative to a template field function for the appropriate radial distance, the ESF spread on average approximately twice as broadly (a scaling factor of two). The magnitude of this scaling factor was considered to be indicative of the site of excitation on the neural fibers. The relationship between two ECAP measures, the spread of ESF and the "spread of excitation" (SOE), is discussed. (c) 2008 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Cohen, LT (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM ltcohen@unimelb.edu.au
FU Commonwealth of Australia through the Co-operative Research Centre for
Cochlear Implant and Hearing Aid Innovation; Department of
Otolaryngology (University of Melbourne, Australia); Bionic Ear
Institute (Melbourne, Australia)
FX I wish to acknowledge support provided by the Commonwealth of Australia
through the Co-operative Research Centre for Cochlear Implant and
Hearing Aid Innovation. I acknowledge, also, additional support provided
by the Department of Otolaryngology (University of Melbourne, Australia)
and the Bionic Ear Institute (Melbourne, Australia). Thanks are due to
the subjects, to Cochlear Limited and to the staff of the Cochlear
Implant Clinic at the Royal Victorian Eye and Ear Hospital, Melbourne,
for their assistance. I am grateful for the encouragement of Mark White.
I thank David Grayden, Barbara Cone-Wesson, Robert Cowan and lan
Jakovenko for their critical reading of the manuscript, and acknowledge
the support of the following in reading and discussing early versions of
this work: Mark White, Richard van Hoesel and Stephen O'Leary. I am
indebted to Patricia Leake for provision of data that enabled
estimation, in the model, of the influence of the angular offset of
ganglion cells relative to their dendritic sites of origin at the organ
of Corti.
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Cohen LT, 2009, HEARING RES, V247, P87, DOI 10.1016/j.heares.2008.11.003
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NR 26
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN 20
PY 2009
VL 247
IS 2
BP 100
EP 111
DI 10.1016/j.heares.2008.11.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 412GZ
UT WOS:000263714500002
PM 19063955
ER
PT J
AU Cohen, LT
AF Cohen, Lawrence T.
TI Practical model description of peripheral neural excitation in cochlear
implant recipients: 3. ECAP during bursts and loudness as function of
burst duration
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Modeling of neural response; ECAP; NRT; Temporal
loudness summation
ID AUDITORY-NERVE FIBER; TEMPORAL INTEGRATION; SPATIAL SPREAD; NUCLEUS;
STIMULATION; HEARING; MASKING; USERS
AB In this, the third paper of the series, the loudness of low-rate bursts of electrical pulses was measured as a function of the burst duration, in subjects implanted with the Nucleus' 24 cochlear implant system (three with straight and two with Contour (TM) electrode arrays). In order to help distinguish between the contributions of peripheral and more central effects, the ECAP was recorded to the individual pulses comprising the bursts, using the Neural Response Telemetry (TM) (NRT (TM)) system. At a pulse rate of 250 pulses/s, the ECAP amplitude did not decrease greatly during the bursts: the mean reduction factor was 0.89. The time-constant for summation of the loudness contributions from the pulses comprising a burst was found to be larger than that associated with normal hearing. In addition, the first pulse of a pulse train was found to contribute much more to the overall loudness than did the subsequent pulses, although a corresponding difference was not observed in the ECAP recordings. These results establish a necessary connection between the essentially single-pulse model, developed in the fourth and fifth papers of the series, and the psychophysical data for pulse bursts, but they also have broader implications. (c) 2008 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Cohen, LT (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM ltcohen@unimelb.edu.au
CR Abbas PJ, 1999, EAR HEARING, V20, P45, DOI 10.1097/00003446-199902000-00005
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Cohen LT, 2009, HEARING RES, V247, P87, DOI 10.1016/j.heares.2008.11.003
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NR 27
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN 20
PY 2009
VL 247
IS 2
BP 112
EP 121
DI 10.1016/j.heares.2008.11.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 412GZ
UT WOS:000263714500003
PM 19068227
ER
PT J
AU D'Alessandro, LM
Norwich, KH
AF D'Alessandro, Lisa M.
Norwich, Kenneth H.
TI Loudness adaptation measured by the simultaneous dichotic loudness
balance technique differs between genders
SO HEARING RESEARCH
LA English
DT Article
DE Loudness adaptation; Gender differences; Loudness exponent
ID SPONTANEOUS OTOACOUSTIC EMISSIONS; AUDITORY ADAPTATION; SEX-DIFFERENCES;
HEARING; TIME
AB Loudness adaptation was measured using the classic simultaneous, dichotic loudness balance technique. A 6-min continuous tone was introduced using headphones to a participant's adapting ear. Immediately upon presentation of the tone and at 1-min intervals, participants adjusted the sound level of a tone of the same frequency in the contralateral control ear until both tones sounded equally loud. The control ear, which was otherwise retained in silence, measured adaptation in the adapting ear. As the constant-sound level stimulus to the adapting ear continued, the sound level that a participant selected to produce equal loudness between ears decreased, oscillating towards an apparent asymptotic value. This value was used to calculate total decibels of adaptation. The magnitude of female adaptation exceeded that of males at all time points measured following stimulus onset. The ratio total dB of adaptation to dB SL of the test tone may provide an empirical estimate for the loudness exponent, n, seen in Stevens' power law, L = k phi(n). which relates the intensity of a pure tone, phi, to the loudness of the tone, L. Since dB of adaptation for females was greater than that of males, female n-values exceeded those of males, in accordance with previous research. (c) 2008 Elsevier B.V. All rights reserved.
C1 [D'Alessandro, Lisa M.; Norwich, Kenneth H.] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada.
[D'Alessandro, Lisa M.; Norwich, Kenneth H.] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
RP Norwich, KH (reprint author), Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada.
EM l.dalessandro@utoronto.ca; k.norwich@utoronto.ca
FU Natural Sciences and Engineering Research Council of Canada; Ontario
Graduate Scholarship
FX This research was supported by a Discovery Grant from the Natural
Sciences and Engineering Research Council of Canada (to KHN) and by an
Ontario Graduate Scholarship (to LMD). This paper is also in memoriam
Ernest Weiler, who passed away on March 22, 2008.
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NR 33
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN 20
PY 2009
VL 247
IS 2
BP 122
EP 127
DI 10.1016/j.heares.2008.10.009
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 412GZ
UT WOS:000263714500004
PM 19027058
ER
PT J
AU Petermann, M
Kummer, P
Burger, M
Lohscheller, J
Eysholdt, U
Dollinger, M
AF Petermann, Miriam
Kummer, Peter
Burger, Martin
Lohscheller, Joerg
Eysholdt, Ulrich
Doellinger, Michael
TI Statistical detection and analysis of mismatch negativity derived by a
multi-deviant design from normal hearing children
SO HEARING RESEARCH
LA English
DT Article
DE Auditory evoked potentials (AEP); Mismatch negativity (MMN); Children;
Statistical analysis; Multi-deviant paradigm
ID EVENT-RELATED POTENTIALS; AUDITORY-DISCRIMINATION; EVOKED-POTENTIALS;
LANGUAGE IMPAIRMENT; ASPERGER-SYNDROME; SPEECH SOUNDS; MATURATION; MMN;
INFANTS; REPRESENTATION
AB To shorten the time of measurement of mismatch negativity (MMN) and to objectify the analysis of MMN characteristics, auditory evoked potentials (AEP) were recorded and MMNs were statistically examined. AEPs from 16 healthy children between the ages of 5 and 7 were elicited using a multi-deviant design including: frequency, duration, intensity, and gap. For detection of MMN an automatic method was applied based on statistical analysis (t-tests) of AEP sweeps. The incidences found were compared to the incidences of MMNs detected by visual inspection of difference waveforms. MMN features such as peak amplitude, peak latency, onset latency, duration of MMN, and area under the curve were evaluated for MMN intervals identified by statistical analysis. MMN incidences identified by statistical analysis (44) reflected a consistency of 84% to visually identified (52) incidences of MMN. Scalp distribution of MMN was mainly fronto-central. Peak latencies of the duration MMN differed significantly from those of the other deviant MMNs. The multi-deviant paradigm was successfully applied for measuring children's AEPs. The statistical approach proved applicable for analysing the data objectively. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Petermann, Miriam; Burger, Martin; Lohscheller, Joerg; Eysholdt, Ulrich; Doellinger, Michael] Univ Hosp Erlangen, Dept Phoniatr & Paediat Audiol, Sch Med, D-91054 Erlangen, Bavaria, Germany.
[Kummer, Peter] Univ Hosp Munchen, Dept Phoniatr & Paediat Audiol, Sch Med, D-80336 Munich, Germany.
RP Dollinger, M (reprint author), Univ Hosp Erlangen, Dept Phoniatr & Paediat Audiol, Sch Med, Bohlenpl 21, D-91054 Erlangen, Bavaria, Germany.
EM Miriam.ct@gmx.de; Peter.Kummer@med.uni-muenchen.de;
Burger.Martin@vdi.de; Joerg.Lohscheller@uk-erlangen.de;
Ulrich.Eysholdt@uk-erlangen.de; Michael.Doellinger@uk-erlangen.de
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Zeftawi MS, 2005, HEARING RES, V210, P24, DOI 10.1016/j.heares.2005.06.012
NR 49
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN 20
PY 2009
VL 247
IS 2
BP 128
EP 136
DI 10.1016/j.heares.2008.11.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 412GZ
UT WOS:000263714500005
PM 19071204
ER
PT J
AU Abaamrane, L
Raffin, F
Gal, M
Avan, P
Sendowski, I
AF Abaamrane, L.
Raffin, F.
Gal, M.
Avan, P.
Sendowski, I.
TI Long-term administration of magnesium after acoustic trauma caused by
gunshot noise in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE Acoustic trauma; Guinea pig; Impulse noise; Magnesium;
Methylprednisolone; NIHL
ID INDUCED HEARING-LOSS; PRODUCT OTOACOUSTIC EMISSIONS;
GLUCOCORTICOID-RECEPTORS; THERAPEUTIC-EFFICACY; INNER-EAR; EXPOSURE;
COCHLEA; MECHANISMS; SYSTEM; REPAIR
AB In a previous study we observed that a 7-day post-trauma magnesium treatment significantly reduced auditory threshold shifts measured 7 days after gunshot noise exposure. However this improvement was only temporary, suggesting that it could be potentially beneficial to prolong this treatment. The aim of the present study was to evaluate the efficacy of a long-term (I month) magnesium treatment after an impulse noise trauma, in comparison with either a 7-day magnesium treatment, an administration of methylprednisolone (conventional treatment), or a placebo (NaCl). Guinea pigs were exposed to impulse noise (three blank gunshots, 170 dB SPL peak). They received one of the four treatments, I h after the noise exposure. Auditory function was explored by recording the auditory brainstem response (ABR) and measuring the distortion product otoacoustic emissions (DPOAE) over a 3-month recovery period after the gunshot exposure. The functional hearing study was supplemented by a histological analysis. The results showed that a 1-month treatment with magnesium was the most effective treatment in terms of hair cell preservation. The DPOAE confirmed this effectiveness. Methylprednisolone accelerated recovery but its final efficacy remained moderate. It is probable that magnesium acts on the later metabolic processes that occur after noise exposure. Multiple mechanisms could be involved: calcium antagonism, anti-ischaemic effect or NMDA channel blockage. Regardless of the specific mechanism, a 1-month treatment with magnesium clearly attenuates NIHL, and presents the advantage of being safe for use in humans. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Abaamrane, L.; Raffin, F.; Sendowski, I.] Ctr Rech Serv Sante Armees, F-38702 La Tronche, France.
[Gal, M.] Hop Instruct Armees Laveran, Serv ORL, F-13998 Marseille, France.
[Avan, P.] Fac Med, EA 2667, Lab Biophys Sensorielle, F-63001 Clermont Ferrand, France.
RP Sendowski, I (reprint author), Ctr Rech Serv Sante Armees, 24 Ave Maquis Gresivaudan,BP 87, F-38702 La Tronche, France.
EM Labaamrane@crssa.net; Fraffin@crssa.net; metmgal@hotmail.com;
Paul.avan@u-clermont.fr; isendowski@crssa.net
FU French army health service [RC2005-21]
FX The authors thank Dr. J. Viret for his valuable advice. This study was
supported by the French army health service (contract no. RC2005-21).
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NR 39
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN 20
PY 2009
VL 247
IS 2
BP 137
EP 145
DI 10.1016/j.heares.2008.11.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 412GZ
UT WOS:000263714500006
PM 19084059
ER
PT J
AU Holmstrom, L
Kim, S
McNames, J
Portfors, C
AF Holmstrom, Lars
Kim, Sunghan
McNames, James
Portfors, Christine
TI Stimulus design for auditory neuroethology using state space modeling
and the extended Kalman smoother
SO HEARING RESEARCH
LA English
DT Article
DE Stimulus design; Extended Kalman filter; Frequency tracking;
Neuroethology; Vocalization
ID FILTER FREQUENCY TRACKER; TEMPORAL RECEPTIVE-FIELD; MISTUNED COMPLEX
TONES; WHITE-CROWNED SPARROW; INFERIOR COLLICULUS; REVERSE-CORRELATION;
MOUSTACHED BAT; NATURAL SOUNDS; PHASE VOCODER; NERVE FIBERS
AB A new method for designing vocalization based stimuli for experiments in auditory neurophysiology is described. This analysis-synthesis technique leverages a state space statistical signal model and the extended Kalman smoother for tracking the frequency, amplitude, and phase information of harmonically related components in recorded vocalizations. Using the same state space model, these parameters can then be used to synthesize the vocalizations and random or deterministic variants of the vocalizations. This method is shown to outperform short-time Fourier transform based frequency tracking methods in both noisy and noise-free synthetic test signals. It is further shown to accurately track recorded hummingbird, human, and bat vocalizations while removing recording artifacts such as noise, echo, and digital aliasing in the synthesis phase. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Holmstrom, Lars; Kim, Sunghan; McNames, James] Portland State Univ, Biomed Signal Proc Lab, Portland, OR 97207 USA.
[Holmstrom, Lars] Portland State Univ, Dept Syst Sci, Portland, OR 97207 USA.
[Kim, Sunghan; McNames, James] Portland State Univ, Coll Engn & Comp Sci, Portland, OR 97207 USA.
[Portfors, Christine] Washington State Univ, Auditory Neurophysiol Lab, Vancouver, WA 98686 USA.
RP Holmstrom, L (reprint author), Portland State Univ, Biomed Signal Proc Lab, POB 751, Portland, OR 97207 USA.
EM larsh@pdx.edu; sunghan@pdx.edu; mcnames@pdx.edu;
portfors@vancouver.wsu.edu
FU NSF [IOS-0620560]
FX This work supported by NSF IOS-0620560.
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NR 54
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 1
EP 16
DI 10.1016/j.heares.2008.09.012
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600001
PM 18977287
ER
PT J
AU Kawamoto, K
Izumikawa, M
Beyer, LA
Atkin, GM
Raphael, Y
AF Kawamoto, Kohei
Izumikawa, Masahiko
Beyer, Lisa A.
Atkin, Graham M.
Raphael, Yehoash
TI Spontaneous hair cell regeneration in the mouse utricle following
gentamicin ototoxicity
SO HEARING RESEARCH
LA English
DT Article
DE Balance; Cochlea; Mouse; Hair cell; Regeneration; Vestibular; Gentamicin
ID CHINCHILLA CRISTA-AMPULLARIS; SCANNING ELECTRON-MICROSCOPY; MATH1
GENE-TRANSFER; INNER-EAR; POSTNATAL-DEVELOPMENT; BASILAR PAPILLA;
EPITHELIUM; PROLIFERATION; RECOVERY; CHICK
AB Whereas most epithelial tissues turn-over and regenerate after a traumatic lesion, this restorative ability is diminished in the sensory epithelia of the inner ear; it is absent in the cochlea and exists only in a limited capacity in the vestibular epithelium. The extent of regeneration in vestibular hair cells has been characterized for several mammalian species including guinea pig, rat, and chinchilla, but not yet in mouse. As the fundamental model species for investigating hereditary disease, the mouse can be studied using a wide variety of genetic and molecular tools. To design a mouse model for vestibular hair cell regeneration research, an aminoglycoside-induced method of complete hair cell elimination was developed in our lab and applied to the murine utricle. Loss of utricular hair cells was observed using scanning electron microscopy, and corroborated by a loss of fluorescent signal in utricles from transgenic mice with GFP-positive hair cells. Regenerative capability was characterized at several time points up to six months following insult. Using scanning electron microscopy, we observed that as early as two weeks after insult, a few immature hair cells, demonstrating the characteristic immature morphology indicative of regeneration, could be seen in the utricle. As time progressed, larger numbers of immature hair cells could be seen along with some mature cells resembling surface morphology of type II hair cells. By six months post-lesion, numerous regenerated hair cells were present in the utricle, however, neither their number nor their appearance was normal. A BrdU assay suggested that at least some of the regeneration of mouse vestibular hair cells involved mitosis. Our results demonstrate that the vestibular sensory epithelium in mice can spontaneously regenerate, elucidate the time course of this process, and identify involvement of mitosis in some cases. These data establish a road map of the murine vestibular regenerative process, which can be used for elucidating the molecular events that govern this process. (c) 2008 Published by Elsevier B.V.
C1 [Izumikawa, Masahiko; Beyer, Lisa A.; Atkin, Graham M.; Raphael, Yehoash] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Kawamoto, Kohei; Izumikawa, Masahiko] Kansai Med Univ, Dept Otolaryngol, Moriguchi, Osaka 5708506, Japan.
RP Raphael, Y (reprint author), Univ Michigan, Dept Otolaryngol Head & Neck Surg, Kresge Hearing Res Inst, MSRB 3,Rm 9301,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
FU Kansai Medical University; NIH/NIDCD [R01-DC01634, R01-DC05401,
R01-DC03685, P30-DC05188]
FX We thank Jian Zuo for the GFP knock-in mice, Anna Lysakowski for helpful
comments and Donald Swiderski for assistance. Work supported by the A.
Alfred Taubman Medical Research Institute, the Berte and Alan
Hirschfield Foundation, the R. Jamison and Betty Williams Professorship,
a Research Grant from Kansai Medical University, and NIH/NIDCD Grants
R01-DC01634, R01-DC05401, R01-DC03685 and P30-DC05188.
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NR 34
TC 45
Z9 50
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 17
EP 26
DI 10.1016/j.heares.2008.08.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600002
PM 18809482
ER
PT J
AU Wittekindt, A
Gaese, BH
Kossl, M
AF Wittekindt, Anna
Gaese, Bernhard H.
Koessl, Manfred
TI Influence of contralateral acoustic stimulation on the quadratic
distortion product f2-f1 in humans
SO HEARING RESEARCH
LA English
DT Article
DE DPOAE; Medial olivocochlear efferents (MOC); Cochlear mechanics;
Difference tone; Cochlear amplifier
ID COCHLEAR MICROMECHANICAL PROPERTIES; CROSSED OLIVOCOCHLEAR BUNDLE; EAR
MUSCLE-REFLEX; OUTER HAIR CELL; OTOACOUSTIC EMISSIONS; MIDDLE-EAR;
EFFERENT SYSTEM; SOUND STIMULATION; GUINEA-PIG; LOW-LEVEL
AB Contralateral acoustic stimulation is known to activate the medial olivocochlear system which is capable of modulating the amplification process in the outer hair cells of the inner ear. We investigated the influence of different levels of contralateral broadband noise on distortion product otoacoustic emissions in humans, with a particular focus on the quadratic distortion product at f2-f1. The primary stimulus frequency ratio was optimized to yield maximum f2-f1 level. While the cubic distortion product at 2f1-f2 was not significantly affected during contralateral noise stimulation, the level of f2-f1 was reduced by up to 4.8 dB on average (maximum: 10.1 dB), with significant suppression occurring for noise levels as low as 40 dB SPL. In addition, a significant phase lead was observed. Quadratic distortions are minimal at a symmetrical position of the transfer function of the cochlear amplifier. The observed sensitivity of f2-f1 to contralateral noise stimulation could hence be resulting from a shift of the operating state and/or a change in the gain of the cochlear amplification due to contralateral induced efferent modulation of the outer hair cell properties. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Wittekindt, Anna; Gaese, Bernhard H.; Koessl, Manfred] Goethe Univ Frankfurt, Inst Zellbiol & Neurowissensch, D-60323 Frankfurt, Germany.
RP Wittekindt, A (reprint author), Goethe Univ Frankfurt, Inst Zellbiol & Neurowissensch, Siesmayerstr 70A, D-60323 Frankfurt, Germany.
EM Anna.Wittekindt@bio.uni-frankfurt.de; Gaese@bio.uni-frankfurt.de;
Koessl@bio.uni-frankfurt.de
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NR 50
TC 6
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 27
EP 33
DI 10.1016/j.heares.2008.09.011
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600003
PM 18951964
ER
PT J
AU Sepmeijer, JW
Klis, SFL
AF Sepmeijer, Jan Willem
Klis, Sjaak F. L.
TI Distribution of platinum in blood and perilymph in relation to cisplatin
induced ototoxicity in the guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE Cisplatin; Ototoxicity; Perilymph; Plasma; Compound action potential
ID CEREBROSPINAL-FLUID; HEARING-LOSS; PHARMACOKINETICS; PARAMETERS;
INFUSIONS; RECOVERY; PLASMA
AB Cisplatin, a platinum-based chemotherapeutic drug, has severe dose-limiting side effects which include ototoxicity. In this study, we investigate the ototoxic effects of cisplatin in relation to the concentration of platinum in whole blood, plasma and perilymph.
Guinea pigs were equipped with a permanent round window electrode for electrocochleography and treated with cisplatin on a daily basis (1.5 mg/kg/day ip) until a 40 dB shift of the compound action potential (CAP) threshold (3 mu V isoresponse criterion) at 8 kHz stimulation occurred. When this criterion was reached blood and perilymph was sampled and the total platinum concentration was measured.
The number of days necessary to reach criterion threshold shift varied from 6 to 22. At this time, platinum concentration was found to be slightly more than 10 times higher in whole blood and plasma than in perilymph. While a significant correlation became apparent between threshold shift and total platinum concentration in whole blood and plasma, this was not the case for threshold shift and platinum concentration in perilymph. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Sepmeijer, Jan Willem; Klis, Sjaak F. L.] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Otorhinolaryngol, Hearing Res Lab, NL-3508 GA Utrecht, Netherlands.
RP Klis, SFL (reprint author), Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Otorhinolaryngol, Hearing Res Lab, Room G 02-531,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM j.w.sepmeijer@umcutrecht.nl; s.klis@umcutrecht.nl
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NR 25
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 34
EP 39
DI 10.1016/j.heares.2008.10.001
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600004
PM 18955125
ER
PT J
AU Feng, YM
Yin, SK
Wang, J
AF Feng, Yanmei
Yin, Shankai
Wang, Jian
TI Cortical responses to amplitude modulation in guinea pigs and the
effects of general anesthesia by pentobarbital
SO HEARING RESEARCH
LA English
DT Article
DE Auditory cortex; Envelope following response; Evoked potential; Guinea
pigs; Temporal resolution
ID ENVELOPE-FOLLOWING RESPONSE; PRIMARY AUDITORY-CORTEX; SINGLE-UNIT
ACTIVITY; INFERIOR COLLICULUS; FREQUENCY REGION; THALAMOCORTICAL
NEURONS; POSTSYNAPTIC POTENTIALS; POTASSIUM CONDUCTANCE; DETECTION
THRESHOLDS; SINUSOIDAL CARRIERS
AB Test of amplitude modulation detection threshold against modulation frequency (Mf) is one of the major measures in behavior studies for exploring temporal acuity of the auditory system. In this experiment, we recorded cortical responses from implanted electrodes in guinea pigs to generate temporal modulation transfer functions (TMTFs) by calculating the response amplitude changes across a range of Mfs in order to evaluate the temporal resolution in different frequency regions. A -3 dB cutoff frequency was measured from each TMTFs and was used as a single-value index for temporal resolution. We found that the temporal resolution, as represented by this index, did not change significantly with the carrier frequency. This result suggested that the temporal resolution of the auditory system is not simply determined by the bandwidth of peripheral auditory channels. We further evaluated the effects of the general anesthesia by pentobarbital on temporal acuity and found that, in addition to the suppressions of response amplitude, this anesthesia significantly decreases the -3 dB cutoff frequencies of TMTF. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Feng, Yanmei; Yin, Shankai; Wang, Jian] Shanghai Jiao Tong Univ, Otolaryngol Inst, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.
[Wang, Jian] Dalhousie Univ, Sch Human Commun Disorders, Halifax, NS B3H 1R2, Canada.
RP Yin, SK (reprint author), Shanghai Jiao Tong Univ, Otolaryngol Inst, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.
EM yinshankai@china.com; jian.wang@dal.ca
FU The Natural Sciences & Engineering Research Council of Canada
[250088-02]; National Natural Science Foundation of China
[30271410/C030310]
FX This study was supported by a grant from The Natural Sciences &
Engineering Research Council of Canada 250088-02 and a grant from The
National Natural Science Foundation of China 30271410/CO30310.
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NR 61
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 40
EP 46
DI 10.1016/j.heares.2008.10.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600005
PM 18992800
ER
PT J
AU Jeng, FC
Abbas, PJ
Hu, N
Miller, CA
Nourski, KV
Robinson, BK
AF Jeng, Fuh-Cherng
Abbas, Paul J.
Hu, Ning
Miller, Charles A.
Nourski, Kirill V.
Robinson, Barbara K.
TI Effects of temporal properties on compound action potentials in response
to amplitude-modulated electric pulse trains in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Amplitude modulation; Compound action potential;
Guinea pig
ID AUDITORY-NERVE FIBERS; COCHLEAR IMPLANT USERS; BRAIN-STEM RESPONSE;
MONOPHASIC STIMULATION; CAT; PATTERNS; RECORDINGS; MONOPOLAR; MODEL; RAT
AB The electrically evoked compound action potential (ECAP) of the auditory nerve in response to amplitude-modulated pulse trains varies over time, but the response amplitudes are not linearly proportional to the level of stimulus pulses. At least two mechanisms could contribute to the deviations of the ECAP response pattern from that of the stimulus envelope. The first mechanism is time-invariant or stationary that reflects the non-linear growth of response amplitude with changes in stimulus level that is evident in the response to single pulses. This can be considered a time-invariant or stationary effect. The second mechanism is time-variant or non-stationary and reflects neural refractoriness and adaptation. The purpose of this study was to characterize the auditory nerve responses to amplitude-modulated pulse trains and also to evaluate the extent to which the stationary and non-stationary effects may contribute to those responses. ECAP amplitudes were predicted from single-pulse growth functions of the auditory nerve to account for time-invariant effects. Linear regression was performed on the measured vs. predicted ECAP amplitudes to quantify the discrepancies between the two datasets, thereby separating the influence of non-linear growth from time-varying effects on ECAP amplitudes. The results demonstrated a bandpass function of the modulated response amplitudes, with a low-cutoff modulation frequency at 300 Hz and a high-cutoff modulation frequency at 800 Hz, depending on the carrier pulse rate. The relative contribution of the temporal effects on ECAP amplitudes is greatest at low stimulus levels and low modulation depths. Published by Elsevier B.V.
C1 [Jeng, Fuh-Cherng] Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
[Jeng, Fuh-Cherng; Abbas, Paul J.; Hu, Ning; Miller, Charles A.; Nourski, Kirill V.; Robinson, Barbara K.] Univ Iowa, Dept Otolaryngol HNS, Dept Commun Sci & Disorders, Iowa City, IA 52242 USA.
RP Jeng, FC (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
EM jeng@ohio.edu
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NR 35
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 47
EP 59
DI 10.1016/j.heares.2008.10.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600006
PM 19015019
ER
PT J
AU Shepherd, D
Hautus, MJ
AF Shepherd, Daniel
Hautus, Michael J.
TI Negative masking and the units problem in audition
SO HEARING RESEARCH
LA English
DT Article
DE Level discrimination; Negative masking; Difference threshold; The units
problem in audition
ID INTENSITY DISCRIMINATION; STOCHASTIC RESONANCE; WEBERS LAW; PSYCHOMETRIC
FUNCTIONS; SEVERE DEPARTURE; SENSORY ANALYSIS; GAUSSIAN-NOISE;
NEAR-MISS; INFORMATION; THRESHOLD
AB Masking functions constructed from pedestal levels bracketing absolute threshold may exhibit negative masking, particularly when stimuli are defined in terms of amplitude (pressure). Three experimental conditions using 10-ms 1000-Hz tones in quiet, 1000-Hz tones embedded in continuous noise and 6500, Hz tones in quiet, yielded negative masking when amplitudes were used to define the stimulus, with the greatest amount of negative masking occurring with 6500-Hz tones. Two models were applied to the data: the transduction model, which assumes direct coupling, and the sensory analytical model, which assumes differential coupling. Maximum likelihood estimates were derived to indicate goodness-of-fit, and the Akaike information criterion and Bayesian information criterion were utilised to adjust for model complexity. Overall, both models effectively accounted for the data, though the sensory analytic model provided the best fits to the data and has the added quality of being based on underlying physiological processes. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Shepherd, Daniel; Hautus, Michael J.] Univ Auckland, Dept Psychol, Auckland, New Zealand.
RP Shepherd, D (reprint author), Univ Auckland, Dept Psychol, Private Bag 92019, Auckland, New Zealand.
EM daniel.shepherd@auckland.ac.nz; m.hautus@auckland.ac.nz
RI Hautus, Michael/B-5077-2008
OI Hautus, Michael/0000-0003-2936-9023
FU University of Auckland's Research Committee
FX This research was supported by a grant from the University of Auckland's
Research Committee.
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NR 61
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 60
EP 70
DI 10.1016/j.heares.2008.10.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600007
PM 19015018
ER
PT J
AU Riecke, L
Mendelsohn, D
Schreiner, C
Formisano, E
AF Riecke, Lars
Mendelsohn, Daniel
Schreiner, Claudia
Formisano, Elia
TI The continuity illusion adapts to the auditory scene
SO HEARING RESEARCH
LA English
DT Article
DE Continuity illusion; Auditory restoration; Adaptation; Auditory scene
analysis; Hearing
ID INDUCED LOUDNESS REDUCTION; FREQUENCY-MODULATED TONES; INTENSITY
DISCRIMINATION; SELECTIVE ADAPTATION; AMPLITUDE-MODULATION;
BACKWARD-MASKING; PSYCHOPHYSICAL EVIDENCE; PERCEPTUAL RESTORATION;
MASKER DURATION; TIME-COURSE
AB The human auditory system is efficient at restoring sounds of interest. In noisy environments, for example, an interrupted target sound may be illusorily heard as continuing smoothly when a loud noise masks the interruptions. In quiet environments, however, sudden interruptions might signal important events. In that case, restoration of the target sound would be disadvantageous. Achieving useful perceptual stability may require the restoration mechanism to adapt its output to current perceptual demands, a hypothesis which has not yet been fully evaluated. In this study, we investigated whether auditory restoration depends on preceding auditory scenes, and we report evidence that restoration adapts to the perceived continuity of target sounds and to the loudness of interrupting sounds. In the first experiment, listeners adapted to illusory and non-illusory tone sweeps (targets) and interrupting noise, and we observed that the perceived continuity of the target and the loudness of the interrupting noise influenced the extent of subsequent restorations. A second experiment revealed that these adaptation effects were unrelated to the adapted spectra, indicating that non-sensory representations of the perceived auditory scene were involved. We argue that auditory restoration is a dynamic illusory phenomenon which recalibrates continuity hearing to different acoustic environments. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Riecke, Lars; Schreiner, Claudia; Formisano, Elia] Maastricht Univ, Fac Psychol, Dept Cognit Neurosci, NL-6200 MD Maastricht, Netherlands.
[Mendelsohn, Daniel] Univ Western Ontario, Schulich Sch Med & Dent, London, ON N6A 3K7, Canada.
RP Riecke, L (reprint author), Maastricht Univ, Fac Psychol, Dept Cognit Neurosci, POB 616, NL-6200 MD Maastricht, Netherlands.
EM l.riecke@psychology.unimaas.nl
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NR 77
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 71
EP 77
DI 10.1016/j.heares.2008.10.006
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600008
PM 19015017
ER
PT J
AU Alvarado, JC
Fuentes-Santamariia, V
Henkel, CK
AF Carlos Alvarado, Juan
Fuentes-Santamaria, Veronica
Henkel, Craig K.
TI Rapid modifications in calretinin immunostaining in the deep layers of
the superior colliculus after unilateral cochlear ablation
SO HEARING RESEARCH
LA English
DT Article
DE Cross-modal; Calcium-binding proteins; Upregulation; Deafferentation;
Hearing loss
ID AUDITORY BRAIN-STEM; CALCIUM-BINDING PROTEINS; INFERIOR COLLICULUS;
NUCLEUS NEURONS; ADULT FERRETS; UP-REGULATION; CELL-DEATH;
IMMUNOREACTIVE NEURONS; SUPERFICIAL LAYERS; OLIVARY COMPLEX
AB Calretinin (CR) is a calcium-binding protein that plays an important role in the homeostasis of intracellular calcium concentration in the auditory pathway. To test if hearing loss could lead indirectly to modifications in levels of this calcium-binding protein in neurons and neuropilar structures outside of the lemniscal auditory pathway, CR-immunostaining was evaluated in the superior colliculus (SC) in adult ferrets at 1, 20 and 90 days after unilateral cochlear ablation. The results demonstrate that within 24 h there was a significant increase in CR-immunostaining in ablated animals as indicated by an increase in the mean gray level of immunostaining in the deep, multisensory layers of the contralateral SC compared to the ipsilateral side and control ferrets. This upregulation was evident in both neurons and neuropil and did not change at the two subsequent time points. In contrast, there was no change in the superficial layers of the SC which have visual properties but no auditory inputs. These findings suggest that upregulation of CR levels within neurons and neuropil in the contralateral deep SC is subject to modifications by activity in multisynaptic auditory pathways. Therefore, cochlear-driven activity appears to affect calcium-binding protein levels not only in auditory nuclei but also in other neural structures whose response properties may be influenced by auditory-related activity. (c) 2008 Published by Elsevier B.V.
C1 [Carlos Alvarado, Juan; Fuentes-Santamaria, Veronica; Henkel, Craig K.] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA.
[Carlos Alvarado, Juan; Fuentes-Santamaria, Veronica] Univ Castilla La Mancha, Sch Med, Dept Med Sci, Reg Ctr Biomed Res, Albacete, Spain.
RP Alvarado, JC (reprint author), Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM juanCarlos.Alvarado@uclm.es
FU National Institute of Health [DC00813]
FX Funded in part by National Institute of Health; Grant number: DC00813.
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NR 59
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2009
VL 247
IS 1
BP 78
EP 86
DI 10.1016/j.heares.2008.10.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 399CI
UT WOS:000262777600009
PM 19017539
ER
PT J
AU Popper, P
Winkler, J
Erbe, CB
Lerch-Gaggl, A
Siebeneich, W
Wackym, PA
AF Popper, Paul
Winkler, John
Erbe, Christy B.
Lerch-Gaggl, Alexandara
Siebeneich, Wolfgang
Wackym, P. Ashley
TI Distribution of two-pore-domain potassium channels in the adult rat
vestibular periphery
SO HEARING RESEARCH
LA English
DT Article
DE Inner ear; Kcnk; 2P-domain K(+) channel; Real-time RT-PCR;
Immunohistochemistry; Confocal microscopy; Vestibular
ID DOMAIN K+ CHANNELS; INNERVATING SEMICIRCULAR CANALS; BACKGROUND K-2P
CHANNELS; SQUIRREL-MONKEY; INNER-EAR; EXPRESSION; TREK-1; LOCALIZATION;
STIMULATION; NEURONS
AB Constitutively active background or "leak" two-pore-domain potassium (K(+)) channels (Kcnk family), as defined by lack of voltage and time dependency are central to electrical excitability of cells by controlling resting membrane potential and membrane resistance. Inhibition of these channels by several neurotransmitters, e.g. glutamate, or acetylcholine, induces membrane depolarization and subsequent action potential firing as well as increases membrane resistance amplifying responses to synaptic inputs. In contrast, their opening contributes to hyperpolarization. Because of their central role in determining cellular excitability and response to synaptic stimulation, these channels likely play a role in the differential effects of vestibular efferent neurons on afferent discharge. Microarray data from previous experiments showed Kcnk 1, 2, 3, 6, 12 and 15 mRNA in Scarpa's ganglia. Real-time RTPCR showed Kcnk 1, 2. 3, 6, 12 and 15 mRNA expression in Scarpa's ganglia and Kcnk 1, 2, 3, 6, 12 but not 15 mRNA expression in the crista ampullaris. We studied the distribution of two-pore-domain potassium channels K(2p)1.1, 2.1, 3.1 and 6.1 like immunoreactivity (corresponding to Kcnk genes 1, 2, 3 and 6) in the vestibular periphery. K(2P)1.1 (TWIK 1) immunoreactivity was detected along nerve terminals, supporting cells and blood vessels of the crista ampullaris and in the cytoplasm of neurons of the Scarpa's ganglia. K(2p)2.1 (TREK I) immunoreactivity was detected in nerve terminals and transitional cells of the crista ampullaris, in the vestibular dark cells and in neuronal fibers and somata of neurons of Scarpa's ganglia. K(2p)3.1 (TASK 1) immunoreactivity was detected in supporting cells and transitional cells of the crista ampullaris, in vestibular dark cells and in neuron cytoplasm within Scarpa's ganglia. K(2p)6.1 (TWIK 2) immunoreactivity was detected in nerve terminals, blood vessels hair cells and transitional cells of the crista ampullaris and in the somata and neuron fibers of Scarpa's ganglia. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Popper, Paul; Winkler, John; Erbe, Christy B.; Siebeneich, Wolfgang; Wackym, P. Ashley] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
[Wackym, P. Ashley] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
[Popper, Paul; Lerch-Gaggl, Alexandara] Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA.
RP Wackym, PA (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM wackym@alumni.vanderbilt.edu
FU NIH/NIDCD [R01DC02971, R03DC006571]; Toohill Research Fund of the
Department of Otolaryngology and Communication Sciences, Medical College
of Wisconsin, Milwaukee, Wisconsin
FX Supported by NIH/NIDCD Grants R01DC02971 (PAW) and R03DC006571 (PP), and
intramural funds from the Toohill Research Fund of the Department of
Otolaryngology and Communication Sciences, Medical College of Wisconsin,
Milwaukee, Wisconsin.
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WACKYM PA, HEARING BALANCE GENE
NR 51
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 1
EP 8
DI 10.1016/j.heares.2008.09.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500001
PM 18838117
ER
PT J
AU Muller, J
Janssen, T
AF Mueller, Joerg
Janssen, Thomas
TI Impact of occupational noise on pure-tone threshold and distortion
product otoacoustic emissions after one workday
SO HEARING RESEARCH
LA English
DT Article
DE Distortion product otoacoustic emissions; Pure-tone threshold;
Occupational noise; Noise-induced hearing loss; Noise vulnerability;
Medial olivocochlear system
ID INDUCED HEARING-LOSS; CROSSED OLIVOCOCHLEAR BUNDLE; CANAL STANDING
WAVES; FINE-STRUCTURE; ACOUSTIC STIMULATION; RAPID ADAPTATION;
INDUSTRIAL NOISE; GROWTH-BEHAVIOR; GUINEA-PIG; HUMANS
AB The aim of this study was to investigate whether distortion product otoacoustic emissions (DPOAEs) are a suitable means for detecting small changes in cochlear amplifier functionality due to Occupational noise exposure of one workday and whether efferent reflex strength of the media] olivocochlear bundle is able to predict the ear's susceptibility to noise. High-resolution (Delta f(2) = 47 Hz) DPOAEs were recorded between 3.5 and 4.5 kHz at close-to-threshold primary tone levels. For comparison, pure-tone audiometry was conducted. Efferent reflex strength was measured by means of DPOAEs at a specific frequency with and without contralateral acoustic stimulation. A statistically significant change was found for pure-tone thresholds (Delta L(ht) = +1.6 +/- 3.0 dB, n = 155) and DPOAE levels (Delta L(dp) = -1.0 +/- 2.4 dB, n 646; L(2) = 20 dB SPL) in factory workers but not in office workers (Delta L(ht) = -1.3 +/- 3.3 dB, n = 80; Delta L(dp) = 0.0 +/- 1.6 dB, n = 336) (control group). However, the influence of systematic biases due to, e.g. ear probe calibration or measurement sequence effects, has to be considered. Moreover, there was no significant correlation between efferent reflex strength and shifts in pure-tone thresholds or shifts in DPOAE levels. Thus, the applied measures of efferent reflex strength do not seem to be suitable for predicting temporary changes in hearing capability. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Mueller, Joerg; Janssen, Thomas] Tech Univ Munich, Hals Nasen Ohren Klin, D-81675 Munich, Germany.
RP Janssen, T (reprint author), Tech Univ Munich, Hals Nasen Ohren Klin, Ismaningerstr 22, D-81675 Munich, Germany.
EM T.Janssem@lrz.tum.de
FU Deutsche Forschungsgemeinschaft [597/9]
FX This work was supported by Deutsche Forschungsgemeinschaft (Ja 597/9).
We thank Wolfram Weinsheimer, executive company medical officer at Voith
AG (Heidenheim, Germany), for supervision and assistance, as well as
Julia Weinsheimer and Zehra Akkaya for recruiting the subjects and
conducting the measurements as part of their medical doctorate thesis.
We thank the reviewers for their valuable comments on the manuscript.
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NR 70
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 9
EP 22
DI 10.1016/j.heares.2008.09.005
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500002
PM 18848612
ER
PT J
AU Verhulst, S
Harte, JM
Dau, T
AF Verhulst, Sarah
Harte, James M.
Dau, Torsten
TI Temporal suppression and augmentation of click-evoked otoacoustic
emissions
SO HEARING RESEARCH
LA English
DT Article
DE Otoacoustic emission; SOAE; CEOAE; Temporal nonlinearity; Suppression;
Cochlear compression
ID STIMULATED ACOUSTIC EMISSIONS; GUINEA-PIG; BASILAR-MEMBRANE; PURE-TONE;
ENHANCEMENT; COCHLEA; MECHANICS; HEARING; MODEL
AB This study investigates temporal suppression of click-evoked otoacoustic emissions (CEOAEs), occurring when a suppressor-click is presented close in time to a test-click (e.g. 0-8 ms). Various temporal suppression methods for examining temporal changes in cochlear compression were evaluated and measured here for seven subjects, both for short- and long-latency CEOAEs. Long-latency CEOAEs (duration >20 ms) typically indicate the presence of synchronised spontaneous otoacoustic emissions (SSOAEs). Temporal suppression can only be linked to changes in CEOAE-compression if the suppressor-click affects the CEOAE magnitude. Phase changes induced by the suppressor-click were shown to bias suppression in two ways: (i) when a specific asymmetric measurement method was used and (ii) when synchronisation between the CEOAE and the click-stimuli was incomplete. When such biases were eliminated, temporal suppression and augmentation (the opposite effect) were observed and shown to be subject-dependent. This indicates that the nonlinearity underlying temporal suppression can work in a more (i.e., suppressed) or less (i.e., augmented) compressive state, depending on the inter-click interval and the subject under test. Temporal suppression was shown to be comparable for CEOAEs and SSOAEs, indicating similar underlying cochlear nonlinear mechanisms. This study contributes to a better understanding of the temporal properties of cochlear dynamics. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Verhulst, Sarah; Harte, James M.; Dau, Torsten] Tech Univ Denmark, Dept Elect Engn, Ctr Appl Hearing Res, DK-2800 Lyngby, Denmark.
RP Verhulst, S (reprint author), Tech Univ Denmark, Dept Elect Engn, Ctr Appl Hearing Res, DK-2800 Lyngby, Denmark.
EM sv@elektro.dtu.dk
FU Technical University of Denmark (DTU); forskerskolen SNAK and GN ReSound
FX The authors would like to thank the anonymous reviewer for constructive
and helpful comments. This work was supported by the Technical
University of Denmark (DTU), forskerskolen SNAK and GN ReSound.
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NR 30
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 23
EP 35
DI 10.1016/j.heares.2008.09.008
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500003
PM 18926894
ER
PT J
AU Zhou, N
Xu, L
AF Zhou, Ning
Xu, Li
TI Lexical tone recognition with spectrally mismatched envelopes
SO HEARING RESEARCH
LA English
DT Article
DE Mandarin Chinese tones; Tone recognition; Spectral shift; Shallow
insertion; Frequency compression; Cochlear implants
ID FREQUENCY-PLACE COMPRESSION; ELECTRODE INSERTION DEPTH;
COCHLEAR-IMPLANT; SPEECH RECOGNITION; TEMPORAL CUES; PERCEPTION;
HEARING; PROSTHESES; CHILDREN; INTELLIGIBILITY
AB It has been shown that frequency-place mismatch has detrimental effects on English speech recognition. The present study investigated the effects of mismatched spectral distribution of envelopes on Mandarin Chinese tone recognition using a noise-excited vocoder. In Experiment 1, speech samples were processed to simulate a cochlear implant with various insertion depths. The carrier bands were shifted basally relative to the analysis bands by 1-7 mm in the cochlea. Nine normal-hearing Mandarin Chinese listeners participated in this experiment. Basal shift of the carriers only slightly affected tone recognition. The resistance of tone recognition to spectral shift can be attributed to the overall amplitude contour cues that are independent from spectral manipulations. Experiment 2 examined the effects of frequency compression, where widened analysis bands by 2, 6, and 10 mm were compressively allocated to narrower carrier bands. Five of the 9 subjects participated in Experiment 2. It appears that the expanded frequency information especially on the low frequency end can compensate for the distortion from frequency compression. Thus, spectral shift might not pose a severe problem for tone recognition, and allocation of wider frequency range to include more low frequency information might be beneficial for tone recognition. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Zhou, Ning; Xu, Li] Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
RP Xu, L (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
EM XuL@ohio.edu
FU NIH NIDCD [R03-DC006161, R15-DC009504]
FX The authors thank Dr. Qian-Jie Fu for providing data from his previous
publication (1999, JASA) to be re-plotted in Fig. 2. The study was
supported in part by NIH NIDCD Grants R03-DC006161 and R15-DC009504.
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NR 45
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 36
EP 43
DI 10.1016/j.heares.2008.09.006
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500004
PM 18848614
ER
PT J
AU Getzmann, S
AF Getzmann, Stephan
TI Effects of velocity and motion-onset delay on detection and
discrimination of sound motion
SO HEARING RESEARCH
LA English
DT Article
DE Spatial hearing; Motion perception; Motion velocity; Response times
ID AUDIBLE MOVEMENT ANGLE; AUDITORY MOTION; HUMAN BRAIN; REACTION-TIME;
TEMPORAL INTEGRATION; MISMATCH NEGATIVITY; HORIZONTAL PLANE; CORTEX;
HUMANS; PERCEPTION
AB The effect of velocity on auditory motion processing in combination with a motion-onset delay was investigated in two experiments. The detection of motion onset and discrimination of motion direction were studied, employing a psychophysical reaction time task. Listeners were presented with sounds moving along the frontal horizontal plane in a dark anechoic environment. Response times (RTs) were measured, while the velocity (20 degrees/s, 40 degrees/s, 80 degrees/s) and the motion-onset delay (the time between sound onset and start of motion: 0, 200, 500, 1000 ms) were varied. Listeners responded faster with higher velocity and longer motion-onset delay. In particular, with higher velocity, the function relating RT to motion-onset delay had a steeper initial decrease than with lower velocities. The results are in line with psychophysical studies of the minimum audible movement angle and recent electrophysiological data about the role of motion velocity in auditory motion processing. The effect of motion-onset delay is discussed with regard to a dynamic temporal window, in which auditory spatial information is integrated until enough information is accumulated to trigger motion detection. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Getzmann, Stephan] Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany.
[Getzmann, Stephan] Ruhr Univ Bochum, D-44780 Bochum, Germany.
RP Getzmann, S (reprint author), Leibniz Res Ctr Working Environm & Human Factors, Ardeystr 67, D-44139 Dortmund, Germany.
EM stephan.getzmann@rub.de
FU Deutsche Forschungsgerneinschaft [Ge 1920/2-1]
FX The author is especially grateful to Jens Kreitewolf for his help in
running the experiments, and to Joachim Hohnsbein for valuable comments
on an earlier draft of the manuscript. This work was supported by the
Deutsche Forschungsgerneinschaft (Ge 1920/2-1).
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NR 42
TC 8
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 44
EP 51
DI 10.1016/j.heares.2008.09.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500005
PM 18848613
ER
PT J
AU Allen, PD
Schmuck, N
Ison, JR
Walton, JP
AF Allen, Paul D.
Schmuck, Nicholas
Ison, James R.
Walton, Joseph P.
TI Kv1.1 channel subunits are not necessary for high temporal acuity in
behavioral and electrophysiological gap detection
SO HEARING RESEARCH
LA English
DT Article
DE Voltage-gated potassium channel; Kv1.1; Inferior colliculus; Prepulse
inhibition
ID INFERIOR COLLICULUS; PREPULSE INHIBITION; STARTLE REFLEX; BRAIN-STEM;
MICE; MOUSE; PRECISION; YOUNG
AB The Kv1.1 potassium channel subunit, encoded by the Kcna 1 gene, is heavily expressed in the auditory brainstem and is thought to have a critical role in producing the high temporal precision of action potentials characteristic of the auditory system. Our intent was to determine whether temporal acuity was reduced in Kcria1 null-mutant (-/-) mice, compared to wild-type (+/+) and heterozygotic mice (+/-), as measured by the encoding of gaps in the inferior colliculus by near-field auditory evoked potentials (NFAEP) or behavioral gap detection (BCD) using a prepulse inhibition paradigm. NFAEPs were collected at 40, 60 and 80 dB SPL with gap durations from 0.5 to 64 ms. BGD data were collected using silent gaps in 70 dB noise from I to 15 ins in duration. There were no systematic effects of Kcna 1 genotype on NFAEP recovery functions, NFAEP latencies, or the time constant for BCD, but there was a small reduction in asymptotic prepulse inhibition for the longest gap stimuli in -/- mice. Gap thresholds were approximately 1-2 ms across genotypes, stimulus conditions, and paradigms. These data suggest that the neural pathways encoding behaviorally relevant, rapid auditory temporal fluctuations are not limited by the absence of Kv1.1 expression. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Allen, Paul D.; Ison, James R.; Walton, Joseph P.] Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
[Allen, Paul D.; Schmuck, Nicholas; Ison, James R.; Walton, Joseph P.] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
[Allen, Paul D.; Ison, James R.] Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY 14627 USA.
RP Walton, JP (reprint author), Univ Rochester, Sch Med & Dent, Dept Otolaryngol, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM pallen@cvs.rochester.edu; nick.schmuck@gmail.com;
jison@bcs.rochester.edu; joseph_walton@urmc.rochester.edu
RI Allen, Paul/A-1228-2007
FU USPHS [AG009524]
FX This research was supported in part by a USPHS grant AG009524, and in
part by the Schmitt Program on Integrative Brain Research. A preliminary
report of these findings was presented at the Association for Research
in Otolaryngology, St. Petersburg Beach, FL, February 2002. We thank two
anonymous reviewers for their helpful critique of a previous version of
this manuscript.
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NR 32
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 52
EP 58
DI 10.1016/j.heares.2008.09.009
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500006
PM 18926893
ER
PT J
AU Snyder, RL
Bonham, BH
Sinex, DG
AF Snyder, Russell L.
Bonham, Ben H.
Sinex, Donal G.
TI Acute changes in frequency responses of inferior colliculus central
nucleus (ICC) neurons following progressively enlarged restricted spiral
ganglion lesions
SO HEARING RESEARCH
LA English
DT Article
DE Plasticity; Inferior colliculus; Hearing loss; Tonotopic reorganization;
Cochleotopic organization; Cochlear lesions; Auditory; Tonotopy
ID DORSAL COCHLEAR NUCLEUS; COMBINATION-SENSITIVE NEURONS; COMPLEX AUDITORY
RESPONSES; SINGLE-UNIT RESPONSES; INDUCED HEARING-LOSS; ADULT
FLYING-FOX; GUINEA-PIG; RECEPTIVE-FIELDS; SOMATOSENSORY CORTEX; LATERAL
LEMNISCUS
AB Immediate effects of sequential and progressively enlarged spiral ganglion (SG) lesions were recorded from cochleas and inferior colliculi. Small SG-lesions produced modest elevations in cochlear tone-evoked compound action potential (CAP) thresholds across narrow frequency ranges; progressively enlarged lesions produced progressively higher CAP-threshold elevations across progressively wider frequency ranges. No comparable changes in distortion product otoacoustic emissions (DPOAEs) amplitudes were observed consistent with silencing of auditory nerve sectors without affecting organ of Corti function.
Frequency response areas (FRAs) of inferior colliculus (IC) neurons were recorded before and immediately after SG-lesions using multi-site silicon arrays fixed in place with recording sites arrayed along IC frequency gradient. Individual post-lesion FRAs exhibited progressively elevated response thresholds and diminished response amplitudes at lesion frequencies, whereas responses at non-lesion frequencies were either unchanged or enhanced. Characteristic frequencies were shifted and silent areas were introduced within these FRAs. Sequentially larger lesions produced sequentially larger shifts in CF and/or enlarged silent areas within affected FRAs, producing immediate changes in IC frequency organization.
These results contrast with those from the auditory nerve, extend previous reports of experience-induced plasticity in the auditory CNS, and support results indicating afferent convergence onto ICC neurons across broad frequency bands. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Snyder, Russell L.] Univ Calif San Francisco, Epstein Lab, Dept Otolaryngol, San Francisco, CA 94143 USA.
[Snyder, Russell L.; Sinex, Donal G.] Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
RP Snyder, RL (reprint author), Univ Calif San Francisco, Epstein Lab, Dept Otolaryngol, Box 0526,U490, San Francisco, CA 94143 USA.
EM rsnyder@ohns.ucsf.edu
FU NIDCD [DC03549, DC00341]
FX The authors would like to thank Drs. CJ. Sumner, J.H. LaVail and an
anonymous reviewer for their thoughtful reading of and comments on this
manuscript. We would also like to acknowledge Support by NIDCD Grants
DC03549 and DC00341.
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NR 76
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2008
VL 246
IS 1-2
BP 59
EP 78
DI 10.1016/j.heares.2008.09.010
PG 20
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 386AA
UT WOS:000261853500007
PM 18938235
ER
PT J
AU Carmichael, ME
Hall, SE
Phillips, DP
AF Carmichael, Martha E.
Hall, Susan E.
Phillips, Dennis P.
TI Ear and contralateral masker effects on auditory temporal gap detection
thresholds
SO HEARING RESEARCH
LA English
DT Article
DE Temporal gap detection; Ear differences; Temporal processing;
Hemispheric asymmetry; Contralateral masking
ID WORD RECOGNITION; LEFT-HEMISPHERE; NORMAL-HEARING; INTERRUPTED NOISE;
SPEECH-PERCEPTION; CORTEX; FREQUENCY; RESOLUTION; LISTENERS;
SPECIALIZATION
AB A temporal processing advantage is thought to underlie the left hemisphere dominance for language. One measure of a temporal processing advantage is temporal acuity or resolution. A standard paradigm for measuring auditory temporal resolution is gap detection in its "with in-channel" and "between-channel" forms. Previous experiments investigating a right ear advantage for within-channel gap detection have yielded conflicting results, and between-channel gap detection has not previously been studied for ear differences. In the present study, the two types of gap detection task were employed, under each of three contralateral masking conditions (no noise, continuous noise and interrupted noise). An adaptive tracking procedure was used to measure the minimal detectable gap at each ear (and therefore, the temporal acuity of the contralateral hemisphere). A significant effect of masking noise was observed in both of the gap detection tasks. Within-channel gap threshold durations were longer in the interrupted noise condition for both ears. Between-channel gap threshold durations were shorter in the interrupted noise condition at the left ear, with a trend in the same direction at the right ear. The study found no significant difference between the ears in thresholds in either gap detection task in any of the masking conditions. This suggests that if the left cerebral hemisphere has a temporal processing advantage, then it is not in the form of acuity for temporal gap detection. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Carmichael, Martha E.; Hall, Susan E.; Phillips, Dennis P.] Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
RP Phillips, DP (reprint author), Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
EM dennis.phillips@dal.ca
RI Phillips, Dennis/A-6496-2011
FU NSERC of Canada; Killam Trust
FX The general questions posed in this experiment were inspired by a
conversation between Dr. Meagan E. Curtis and DPP at the 2004 meeting of
the American Psychological Association. The research was supported by
Grants to DPP from NSERC of Canada and the Killam Trust. We specially
thank two anonymous reviewers who provided helpful commentary on a
previous version of this report, and the anonymous reviewer who provided
help with the power calculations used in the interpretation of the
statistical data.
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NR 51
TC 6
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 18
EP 23
DI 10.1016/j.heares.2008.08.002
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700004
PM 18761067
ER
PT J
AU Chikar, JA
Colesa, DJ
Swiderski, DL
Di Polo, A
Raphael, Y
Pfingst, BE
AF Chikar, Jennifer A.
Colesa, Deborah J.
Swiderski, Donald L.
Di Polo, Adriana
Raphael, Yehoash
Pfingst, Bryan E.
TI Over-expression of BDNF by adenovirus with concurrent electrical
stimulation improves cochlear implant thresholds and survival of
auditory neurons
SO HEARING RESEARCH
LA English
DT Article
DE Animal psychophysics; EABR; Spiral ganglion cell; Growth factors;
Electrical stimulation; Gene therapy; Adenovirus; Ad.BDNF
ID SPIRAL GANGLION NEURONS; SENSORINEURAL HEARING-LOSS; MEDIATED
GENE-TRANSFER; DEAFENED GUINEA-PIG; NEUROTROPHIC FACTOR;
ETHACRYNIC-ACID; IN-VIVO; NERVE; DEGENERATION; INNERVATION
AB The survival of the auditory nerve in cases of sensorineural hearing loss is believed to be a major factor in effective cochlear implant function. The current study assesses two measures of cochlear implant thresholds following a post-deafening treatment intended to halt auditory nerve degeneration. We used an adenoviral construct containing a gene insert for brain-derived neurotrophic factor (BDNF), a construct that has previously been shown to promote neuronal survival in a number of biological systems. We implanted ototoxically deafened guinea pigs with a multichannel cochlear implant and delivered a single inoculation of an adenovirus suspension coding for BDNF (Ad.BDNF) into the scala tympani at the time of implantation. Thresholds to electrical stimulation were assessed both psychophysically and electrophysiologically over a period of 80 days. Spiral ganglion cell survival was analyzed at the 80 days time point. Compared to the control group, the Ad.BDNF treated group had lower psychophysical and electrophysiological thresholds as well as higher survival of spiral ganglion cells. Electrophysiological, but not psychophysical, thresholds correlated well with the density of spiral ganglion cells. These results indicate that the changes in the anatomy of the auditory nerve induced by the combination of Ad.BDNF inoculation and the electrical stimulation used for testing improved functional measures of Cl performance. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Raphael, Yehoash] Univ Michigan, Kresge Hearing Res Inst, Sch Med, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
[Chikar, Jennifer A.; Raphael, Yehoash; Pfingst, Bryan E.] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA.
[Di Polo, Adriana] Univ Montreal, Dept Pathol & Cell Biol, Montreal, PQ H3C 3J7, Canada.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, Sch Med, Dept Otolaryngol, 1150 W Med Ctr Dr,9301 MSRB 3, Ann Arbor, MI 48109 USA.
EM jchikar@umich.edu; djmorris@umich.edu; dlswider@umich.edu;
adriana.di.polo@umontreal.ca; yoash@umich.edu; bpfingst@umich.edu
FU Royal National Institute for Deaf and Hard of Hearing People (RNID); A.
Alfred Taubman Medical Research Institute; NIH [R01-DC03389,
ROI-DC05401, T32DC00011, P30-DC05188]
FX We thank Jennifer Benson, Lisa Beyer, Matthew Johnson, Kohei Kawamoto,
Chen-Chung Lee, Ryosej Minoda, Toshihiko Nakaizumi, Taha Qazi, and Gina
Su for technical support and assistance in completion of this study.
This work was supported by The Royal National Institute for Deaf and
Hard of Hearing People (RNID), the R. Jamison and Betty Williams
Professorship, a gift from Bette and Alan Hirschfield, the A. Alfred
Taubman Medical Research Institute, and NIH Grants R01-DC03389,
ROI-DC05401, T32DC0001 I and P30-DC05188.
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NR 47
TC 35
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 24
EP 34
DI 10.1016/j.heares.2008.08.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700005
PM 18768155
ER
PT J
AU Aiken, SJ
Picton, TW
AF Aiken, Steven J.
Picton, Terence W.
TI Envelope and spectral frequency-following responses to vowel sounds
SO HEARING RESEARCH
LA English
DT Article
DE Auditory evoked potentials; Frequency-following responses; Speech
envelope; Vowel sounds; Fourier analyzer
ID STEADY-STATE RESPONSES; AUDITORY-EVOKED-POTENTIALS; BRAIN-STEM RESPONSE;
OTOACOUSTIC EMISSIONS; PRESSURE MEASUREMENTS; DISTORTION PRODUCTS;
LEARNING-PROBLEMS; NORMAL-HEARING; SPEECH SOUNDS; NERVE FIBERS
AB Frequency-following responses (FFRs) were recorded to two naturally produced vowels (/a/ and /i/) in normal hearing Subjects. A digitally implemented Fourier analyzer was used to measure response amplitude at the fundamental frequency and at 23 higher harmonics. Response components related to the stimulus envelope ("envelope FFR") were distinguished from components related to the stimulus spectrum ("spectral FFR") by adding or subtracting responses to opposite polarity stimuli. Significant envelope FFRs were detected at the fundamental frequency of both vowels, for all of the subjects. Significant spectral FFRs were detected at harmonics close to formant peaks, and at harmonics corresponding to cochlear intermodulation distortion products, but these were not significant in all subjects, and were not detected above 1500 Hz. These findings indicate that speech-evoked FFRs follow both the glottal pitch envelope as well as spectral Stimulus components. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Aiken, Steven J.] Dalhousie Univ, Sch Human Commun Disorders, Halifax, NS B3H 1R2, Canada.
[Picton, Terence W.] Univ Toronto, Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M5S 1A1, Canada.
RP Aiken, SJ (reprint author), Dalhousie Univ, Sch Human Commun Disorders, 5599 Fenwick St, Halifax, NS B3H 1R2, Canada.
EM steve.aiken@dal.ca
FU Canadian Institutes for Health Research; James Knowles; Patricia Van
Roon
FX This study was supported by a Grant from the Canadian Institutes for
Health Research and by funds donated by James Knowles. Patricia Van Roon
provided technical assistance with the recordings and with the
manuscript.
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NR 63
TC 79
Z9 80
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 35
EP 47
DI 10.1016/j.heares.2008.08.004
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700006
PM 18765275
ER
PT J
AU Hu, BH
Yang, WP
Bielefeld, EC
Li, M
Chen, GD
Henderson, D
AF Hu, Bo Hua
Yang, Wei-Ping
Bielefeld, Eric C.
Li, Manna
Chen, Guang-Di
Henderson, Donald
TI Apoptotic outer hair cell death in the cochleae of aging Fischer
344/NHsd rats
SO HEARING RESEARCH
LA English
DT Article
DE Aging; Apoptosis; Necrosis; Outer hair cell; Fischer 344/NHsd rat
ID NOISE-INDUCED APOPTOSIS; CYTOCHROME-C; CHROMATIN CONDENSATION; INTENSE
NOISE; AGED COCHLEA; CANCER-CELLS; BAX; PATHWAYS; MITOCHONDRIA; CLEAVAGE
AB Apoptotic cell death has been implicated in cochlear degeneration during aging. To better understand the impact and the biological process of outer hair cell (OHC) apoptosis, we investigated the contribution apoptotic cell death to the formation of the OHC lesions, and observed the temporal patterns of the occurrence of apoptotic events associated with the mitochondrial pathway in Fischer 344/NHsd rats, with ages ranging from 20 to 27 months. The results showed that the ratio of apoptotic to necrotic OHCs was 8:1. During the process of cell degeneration, the onset of Bax expression, cytochrome c release, and nuclear DNA fragmentation preceded the onset of nuclear condensation. in contrast, the activation of caspases-3 and -9, as well as the degradation of F-actin, took place after the onset of nuclear condensation. The results of this study suggest that the initiation of nuclear degradation is a caspase-3-indepenclent process. Moreover, the study revealed that OHCs with Bax expression or cytochrome c release could enter either the apoptotic or necrotic pathway, suggesting the presence of a regulatory mechanism that guides degenerating OHCs to die via either the apoptotic or necrotic pathway. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Hu, Bo Hua; Bielefeld, Eric C.; Li, Manna; Chen, Guang-Di; Henderson, Donald] SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
[Yang, Wei-Ping] Peoples Liberat Army Gen Hosp, Inst Otolaryngol, Beijing 100853, Peoples R China.
RP Hu, BH (reprint author), SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM bhu@acsu.buffalo.edu
RI Bielefeld, Eric/D-2015-2012
FU NIDCD [1R01DC0068201A1, 2006BA102BO6]
FX The Study was supported by NIDCD 1R01DC0068201A1 and 2006BA102BO6.
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NR 33
TC 12
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 48
EP 57
DI 10.1016/j.heares.2008.08.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700007
PM 18778762
ER
PT J
AU Sun, W
Hansen, A
Zhang, LY
Lu, JZ
Stolzberg, D
Kraus, KS
AF Sun, Wei
Hansen, Anna
Zhang, Liyan
Lu, Jianzhong
Stolzberg, Daniel
Kraus, Kari Suzanne
TI Neonatal nicotine exposure impairs development of auditory temporal
processing
SO HEARING RESEARCH
LA English
DT Article
DE Nicotine; Startle reflex; Gap detection; Development; Auditory cortex
ID PREPULSE INHIBITION; GAP DETECTION; CORTEX; LANGUAGE; RAT; PREGNANCY;
SYSTEM; AGE; EXPERIENCE; RESPONSES
AB Accurate temporal processing of sound is essential for detecting word structures in speech. Maternal smoking affects speech processing in newborns and may influence child language development; however, it is unclear how neonatal exposure to nicotine, present in cigarettes, affects the normal development of temporal processing. The present study used the gap-induced prepulse inhibition (gap-PPI) of the acoustic startle response to investigate the effects of neonatal nicotine exposure on the normal development of gap detection, a behavioral testing procedure of auditory temporal resolution. Neonatal rats were injected twice per day with saline (control), 1 mg/kg nicotine (N-1 mg) or 5 mg/kg nicotine (N-5 mg) from postnatal day 8-12 (P8-P12). During the first month after birth, rats showed poor gap-PPI in all three groups. At P45 and P60, gap-PPI in control rats improved significantly, whereas rats exposed to nicotine exhibited less improvement. At P60, the gap-detection threshold in the N-5 mg group was significantly higher than in the control group, suggesting that neonatal nicotine exposure affects the normal development of gap-detection acuity. Additionally, 1 h after receiving an acute nicotine injection (I mg/kg), gap-PPI recorded in adult rats from the N-5 mg group showed a temporary significant improvement. These results suggest that neonatal nicotine exposure reduces gap-PPI implying an impairment of the normal development of auditory temporal processing by inducing changes in cholinergic systems. Published by Elsevier B.V.
C1 [Sun, Wei; Hansen, Anna; Zhang, Liyan; Lu, Jianzhong; Stolzberg, Daniel; Kraus, Kari Suzanne] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
[Sun, Wei; Hansen, Anna] SUNY Buffalo, Dept Commun Disorders & Sci, Buffalo, NY 14214 USA.
RP Sun, W (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 3435 Main St, Buffalo, NY 14214 USA.
EM weisun@buffalo.edu; aghansen@buffalo.edu; liyanzhang007@hotmail.com;
jlu6@buffalo.edu; djs32@buffalo.edu; skkraus@buffalo.edu
FU National Institute of Health [DC008685-01]; National Organization for
Hearing Research
FX We thank Dr. Ison and Dr. Allen at the University at Rochester for
generously sharing the custom software for startle reflex testing. This
project is supported by grants from National Institute of Health
(DC008685-01) and National Organization for Hearing Research.
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NR 35
TC 8
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 58
EP 64
DI 10.1016/j.heares.2008.08.009
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700008
PM 18801421
ER
PT J
AU Ehmann, H
Salzig, C
Lang, P
Friauf, E
Nothwang, HG
AF Ehmann, Heike
Salzig, Christian
Lang, Patrick
Friauf, Eckhard
Nothwang, Hans Gerd
TI Minimal sex differences in gene expression in the rat superior olivary
complex
SO HEARING RESEARCH
LA English
DT Article
DE Auditory system; Superior olivary complex; Transcriptome; Sexual
dimorphism
ID AUDITORY BRAIN-STEM; INFERIOR COLLICULUS; OTOACOUSTIC EMISSIONS; GENDER
DIFFERENCES; COCHLEAR NUCLEUS; EAR ASYMMETRIES; PITUITARY-GLAND;
TEMPORAL-ORDER; X-INACTIVATION; AGE
AB A critical issue in large-scale gene expression analysis is the impact of sexually dimorphic genes, which may confound the results when sampling across sexes. Here, we assessed, for the first time, sex differences at the transcriptome level in the auditory brainstem. To this end, microarray experiments covering the whole rat genome were performed in the superior olivary complex (SOC) of 16-day-old Sprague-Dawley rats. Sexually dimorphic genes were identified using two criteria: a >= 2-fold change and a P-value < 0.05. Only 12 out of 41,374 probes (0.03%) showed sexually dimorphic expression. For companson, pituitaries from 60-day-old female and male rats were analyzed, as this gland is known to display many sex-specific features. Indeed, almost 40 times more probes, i.e. 460 (1.1 %), displayed sexual dimorphism. Quantitative RT-PCR confirmed 47 out of 48 microarray results from both tissues. Taking microarray and qRT-PCR data together, the expression of six genes (Prl, Eif2s3y, Gnrhr, Panic, Ddx3y, Akr1c6) was higher in the male SOC, whereas two genes were upregulated in the female SOC (LOC302172, Xist). Four of these genes are sex-chromosome linked (Eif2s3y, Ddx3y, LOC302172, Xist). In summary, our data indicate only minor and negligible sex-specific differences in gene expression within the SOC at P16. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Ehmann, Heike; Friauf, Eckhard; Nothwang, Hans Gerd] Univ Kaiserslautern, Dept Biol, Anim Physiol Grp, D-67653 Kaiserslautern, Germany.
[Salzig, Christian; Lang, Patrick] Fraunhofer Inst Ind Math ITWM, Dept Syst Anal Prognosis & Control, D-67663 Kaiserslautern, Germany.
[Nothwang, Hans Gerd] Carl VonOssietzky Univ Oldenburg, Dept Neurogenet, D-26111 Oldenburg, Germany.
RP Nothwang, HG (reprint author), Univ Kaiserslautern, Dept Biol, Anim Physiol Grp, POB 3049, D-67653 Kaiserslautern, Germany.
EM ehmann@rhrk.uni-kl.de; christian.salzig@itwm.fraunhofer.de;
patrick.lang@itwm.fraunhofer.de; eckhard.friauf@biologie.uni-kl.de;
hans.g.nothwang@uni-oldenburg.de
RI Nothwang, Hans/C-5847-2011; Friauf, Eckhard/D-7529-2012
OI Friauf, Eckhard/0000-0002-1833-1698
FU State Rhineland Palatinate
FX We thank Anja Feistner for excellent technical support, members of the
Kaiserslautern group for comments during the course of this work, and
Karsten Andresen (Institut fiJr Biotechnologie und Wirkstoff-Forschung,
Kaiserslautern) for helpful discussions with the analysis. This work was
supported by an A4 grant of the State Rhineland Palatinate within the
Hochschulprogramm Wissen schafft Zukunft.
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NR 51
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 65
EP 72
DI 10.1016/j.heares.2008.08.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700009
PM 18793710
ER
PT J
AU Hayashi, H
Kunisada, T
Takakura, N
Aoki, M
Mizuta, K
Ito, Y
AF Hayashi, Hisamitsu
Kunisada, Takahiro
Takakura, Nobuyuki
Aoki, Mitsuhiro
Mizuta, Keisuke
Ito, Yatsuji
TI Involvement of platelet-derived growth of mesenchyme and sensory
epithelium factor receptor-beta in maintenance of the neonatal mouse
inner ear
SO HEARING RESEARCH
LA English
DT Article
DE Platelet-derived growth factor receptor; Inner ear; Mesenchymal tissue;
Neonatal mouse; Immunohistochemistry; APB5
ID PROTEASE-ACTIVATED LIGAND; BLOOD-LABYRINTH BARRIER; PDGF-ALPHA-RECEPTOR;
DEFICIENT MICE; CELL-DEVELOPMENT; HAIR-CELLS; RAT; EXPRESSION; COCHLEA;
MORPHOGENESIS
AB Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RTPCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PDGFR-beta antibody, APB5, to investigate the role of PDGFR-beta in the neonatal mouse inner ear. PDGFR-beta was detected immunohistochemically in the mesenchymal tissue adjacent to the sensory epithelium of the inner ear, and a ligand for PDGFR-beta was detected around the sensory epithelium. To determine whether this expression plays a functional role, we injected APB5 into neonates to block the function of PDGFR-beta. Mesenchymal tissue defects and abnormal capillaries with irregular shapes, especially in the cochlear lateral wall, were detected in APB5-treated mice. The results of a TUNEL assay revealed that not only the adjacent mesenchymal cells but also the sensory epithelial cells underwent cell death. These results indicate that PDGFR-beta signals are required for the survival of the capillary and mesenchymal cells in the neonatal mouse inner ear and also indirectly implicate these signals in the survival of the sensory epithelium. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Hayashi, Hisamitsu; Aoki, Mitsuhiro; Mizuta, Keisuke; Ito, Yatsuji] Gifu Univ, Grad Sch Med, Dept Otolaryngol, Gifu 5011194, Japan.
[Kunisada, Takahiro] Gifu Univ, Grad Sch Med, Dept Tissue & Organ Dev, Gifu 5011194, Japan.
[Takakura, Nobuyuki] Osaka Univ, Microbial Dis Res Inst, Dept Signal Transduct, Suita, Osaka 565087, Japan.
RP Hayashi, H (reprint author), Gifu Univ, Grad Sch Med, Dept Otolaryngol, 1-1 Yanagido, Gifu 5011194, Japan.
EM hh@gifu-u.ac.jp; kunisad@gifu-u.ac.jp; ntakaku@biken.osaka-u.ac.jp;
aoki@gifu-u.ac.jp; kmizuta@gifu-u.ac.jp; ity@gifu-u.ac.jp
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NR 43
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 73
EP 81
DI 10.1016/j.heares.2008.08.01
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700010
PM 18817860
ER
PT J
AU Popelar, J
Grecova, J
Rybalko, N
Syka, J
AF Popelar, Jiri
Grecova, Jolana
Rybalko, Natalia
Syka, Josef
TI Comparison of noise-induced changes of auditory brainstem and middle
latency response amplitudes in rats
SO HEARING RESEARCH
LA English
DT Article
DE Noise exposure; Long evans rats; Middle latency responses; Auditory
brainstem responses; Amplitude-intensity functions
ID DORSAL COCHLEAR NUCLEUS; CENTRAL-NERVOUS-SYSTEM; INDUCED HEARING-LOSS;
AWAKE GUINEA-PIGS; INFERIOR COLLICULUS; EVOKED-RESPONSES; ACOUSTIC
TRAUMA; ELECTRICAL-STIMULATION; DISCHARGE PATTERNS; GENERATOR SYSTEMS
AB Auditory brainstem responses (ABRs) and middle latency responses (MLRs) were compared after noise exposure to elucidate the specific effects of a loud sound on the central auditory system in rats. Rats were exposed twice for I h to broad-band noise (BBN) of 118 dB SPL (first exposure) and 122 dB SPL (second exposure) with an interval between the exposures of three weeks. The first noise exposure produced threshold shifts (TSs) amounting to 5-45 dB, and the second exposure resulted in 40-70 dB TSs. The slope of MLR amplitude-intensity functions (AIFs) increased significantly in correlation with the TS, resembling loudness recruitment. However, maximal MLR amplitudes measured at 8 kHz increased after the first and second noise exposures to almost equal values in individual animals regardless of the TS. In addition, maximum MLR amplitude enhancement was dependent on pre-exposure MLR voltage, probably reflecting the level of metabolic activity or neurotransmitter processes in individual animals. In contrast to MLR amplitudes, ABR amplitudes were suppressed after noise exposure without changing the slope of ABR AIFs. The MLR changes reflect the specific effects of noise exposure on the central auditory system. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Popelar, Jiri; Grecova, Jolana; Rybalko, Natalia; Syka, Josef] Acad Sci Czech Republic, Inst Expt Med, VVI, Prague 14220 4, Czech Republic.
RP Popelar, J (reprint author), Acad Sci Czech Republic, Inst Expt Med, VVI, Videnska 1083, Prague 14220 4, Czech Republic.
EM jpopelar@biomed.cas.cz
RI Rybalko, Natalia/H-2629-2014; Popelar, Jiri/H-2558-2014; Syka,
Josef/H-3103-2014
FU Grant Agency of the Czech Republic [AVOZ50390512, 309/07/1336]; Internal
Grant Agency of the Czech Ministry of Health [NR 8113-4]; Center of
Neuroscience [LC 554]
FX The study was supported by Grants AVOZ50390512 and 309/07/1336 from the
Grant Agency of the Czech Republic, NR 8113-4 from the Internal Grant
Agency of the Czech Ministry of Health and LC 554 from the Center of
Neuroscience.
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NR 68
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 82
EP 91
DI 10.1016/j.heares.2008.09.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700011
PM 18812219
ER
PT J
AU Spankovich, C
Hood, LJ
Grantham, DW
Polley, DB
AF Spankovich, Christopher
Hood, Linda J.
Grantham, D. Wesley
Polley, Daniel B.
TI Application of frequency modulated chirp stimuli for rapid and sensitive
ABR measurements in the rat
SO HEARING RESEARCH
LA English
DT Article
DE ABR; Amplitude; Threshold; Chirp; Mouse; Rat
ID BRAIN-STEM RESPONSES; AUDITORY-EVOKED-RESPONSES; TONE BURSTS; SIGNALS;
HUMANS
AB Rodents have proven to be a useful model system to screen genes, ototoxic compounds and sound exposure protocols that may play a role in hearing loss. High-throughput screening depends upon a rapid and reliable functional assay for hearing loss. This study describes the use of a frequency modulated (FM) chirp stimulus as an alternative to the click to derive a rapid assessment of auditory brainstem response (ABR) threshold in the rodent. We designed a rising frequency A-chirp based upon the spatial mapping of preferred frequency along the rat basilar membrane to provide a more synchronous and equipotent input across the length of the cochlea. We observed that the ABR wave I and wave IV amplitudes evoked by the A-chirp were significantly greater than the click and that A-chirp minimum response thresholds were lower than the click. Subsequent analyses compared the efficacy of the A-chirp to linear, time-reversed and amplitude-reversed chirps and confirmed that the A-chirp was most effective chirp configuration. These data suggest that the A-chirp may be optimally suited as a single screening broad-frequency stimulus for rapid ABR threshold estimations in the rodent and could serve to complement more detailed frequency-specific physiologic and behavioral estimates of hearing threshold. (C) 2008 Published by Elsevier B.V.
C1 [Spankovich, Christopher; Hood, Linda J.; Grantham, D. Wesley; Polley, Daniel B.] Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci, Vanderbilt Bill Wilkerson Ctr Otolaryngol & Commu, Nashville, TN 37232 USA.
[Hood, Linda J.; Polley, Daniel B.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37202 USA.
RP Polley, DB (reprint author), Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci, Vanderbilt Bill Wilkerson Ctr Otolaryngol & Commu, 465 21st Ave South,7114C MRB 3, Nashville, TN 37232 USA.
EM daniel.polley@vanderbilt.edu
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NR 20
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 92
EP 97
DI 10.1016/j.heares.2008.09.001
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700012
PM 18812220
ER
PT J
AU Vermeire, K
Nobbe, A
Schleich, P
Nopp, P
Voormolen, MH
Van de Heyning, PH
AF Vermeire, Katrien
Nobbe, Andrea
Schleich, Peter
Nopp, Peter
Voormolen, Maurits H.
Van de Heyning, Paul H.
TI Neural tonotopy in cochlear implants: An evaluation in unilateral
cochlear implant patients with unilateral deafness and tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE Single-sided deafness; Cochlear implants; Tonotopy; Greenwood
ID PITCH PERCEPTION; RESIDUAL HEARING; EAR; MAP
AB In cochlear implants, the signal is filtered into different frequency bands and transmitted to electrodes along the cochlea. In this study the frequency-place function for electric hearing was investigated as a means to possibly improve speech coding by delivering information to the appropriate cochlear place.
Fourteen subjects with functional hearing in the contralateral ear have been provided with a MED-EL cochlear implant in the deaf ear in order to reduce intractable tinnitus. Pitch scaling experiments were performed using single-electrode, constant-amplitude, constant-rate stimuli in the implanted ear, and acoustic sinusoids in the contralateral ear. The frequency-place function was calculated using the electrode position in the cochlea as obtained from postoperative skull radiographs. Individual frequency-place functions were compared to Greenwood's function in normal hearing. Electric stimulation elicited a low pitch in the apical region of the cochlea, and shifting the stimulating electrode towards the basal region elicited increasingly higher pitch. The frequency-place function did not show a significant shift relative to Greenwood's function.
In cochlear implant patients with functional hearing in the non-implanted ear, electrical stimulation produced a frequency-place function that on average resembles Greenwood's function. These results differ from previously derived data. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Vermeire, Katrien] Univ Innsbruck, Inst Ion Phys & Appl Phys, C Doppler Lab Act Implantable Syst, A-6020 Innsbruck, Austria.
[Nobbe, Andrea; Schleich, Peter; Nopp, Peter] MED EL GmbH, A-6020 Innsbruck, Austria.
[Voormolen, Maurits H.] Univ Antwerp, Univ Antwerp Hosp, Dept Radiol, B-2650 Edegem, Belgium.
[Vermeire, Katrien; Van de Heyning, Paul H.] Univ Antwerp, Univ Antwerp Hosp, Dept Otorhinolaryngol & Head & Neck Surg, B-2650 Edegem, Belgium.
RP Vermeire, K (reprint author), Univ Innsbruck, Inst Ion Phys & Appl Phys, C Doppler Lab Act Implantable Syst, Technikerstr 25, A-6020 Innsbruck, Austria.
EM katrien.vermeire@uibk.ac.at; Andrea.nobbe@web.de;
Peter.schleich@medel.com; Peter.nopp@medel.com;
Maurits.voormolen@uza.be; Paul.van.de.heyning@uza.be
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NR 21
TC 23
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2008
VL 245
IS 1-2
BP 98
EP 106
DI 10.1016/j.heares.2008.09.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 381WD
UT WOS:000261565700013
PM 18817861
ER
PT J
AU Markaryan, A
Nelson, EG
Tretiakova, M
Hinojosa, R
AF Markaryan, Adam
Nelson, Erik G.
Tretiakova, Maria
Hinojosa, Raul
TI Technical report: Laser microdissection of cochlear structures from
celloidin embedded human temporal bone tissues and detection of the
mitochondrial DNA common deletion using real time PCR
SO HEARING RESEARCH
LA English
DT Article
DE Laser microdissection; Human temporal bones; Mitochondrial DNA deletions
ID POLYMERASE-CHAIN-REACTION; FORMALDEHYDE; DEGRADATION; SPECIMENS;
PATHOLOGY; FIXATION
AB Laser microdissection (LMD) has been used to isolate groups of cells and single cells from numerous tissues. in this study, we describe a technique for isolating cochlear structures and individual spiral ganglion cells from archival celloidin embedded human temporal bone sections. The specimens isolated are suitable for quantifying the mitochondrial DNA (mtDNA) common deletion (CD) within these tissues using a real time polymerase chain reaction (PCR) assay. The results presented in this manuscript demonstrate the feasibility of using this LMD technique to study the accumulation of mtDNA deletions in diseases of the ear. To our knowledge, this approach to analyzing archival human temporal bone tissues has not been previously reported. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Markaryan, Adam; Nelson, Erik G.; Hinojosa, Raul] Univ Chicago, Dept Surg, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA.
[Tretiakova, Maria] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA.
RP Markaryan, A (reprint author), Univ Chicago, Dept Surg, Sect Otolaryngol Head & Neck Surg, 5841 S Maryland Ave,MC 1035, Chicago, IL 60637 USA.
EM amarkary@surgery.bsd.uchicago.edu
FU Bloom Endowment Fund; American Hearing Research Foundation
FX This research was supported by the Bloom Endowment Fund and in part by
the 2007 Wiley H. Harrison, M.D. Grant from the American Hearing
Research Foundation.
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NR 24
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 1
EP 6
DI 10.1016/j.heares.2008.07.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200001
PM 18706496
ER
PT J
AU Davids, T
Valero, J
Papsin, BC
Harrison, RV
Gordon, KA
AF Davids, Taryn
Valero, Jerome
Papsin, Blake C.
Harrison, Robert V.
Gordon, Karen A.
TI Effects of stimulus manipulation on electrophysiological responses in
pediatric cochlear implant users. Part I: Duration effects
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Electrical stimulation; Duration of stimulation;
Electrophysiological thresholds; Behavioral thresholds
ID AUDITORY BRAIN-STEM; MIDDLE LATENCY RESPONSE; ELECTRICAL-STIMULATION;
TEMPORAL INTEGRATION; CLINICAL IMPLICATIONS; ACTION-POTENTIALS; GROWTH
FUNCTIONS; CHILDREN; NERVE; HEARING
AB Discrepancies between electrophysiological and behavioral thresholds in cochlear implant users might be due to differences in stimuli such as the duration and rate of the electrical pulse train. In the present study, we asked: Is there an effect of stimulus duration on electrophysiological responses of the auditory brainstem, thalamo-cortex, and behavioral thresholds?
In 5 pediatric cochlear implant users, behavioral thresholds in response to electrical pulse trains at 500 pulses per second (pps) were significantly lower for 40 ms than 2 ms duration pulse trains.
Clear electrically evoked auditory brainstern responses (EABR) and electrically evoked middle latency responses (EMLR) were generated by single electrical pulses and 2, 6, and 10 ms pulse trains (500 pps) in 5 children. There was a linear decrease in the inter-wave latency between the eV of the EABR and the Na of the EMLR as duration increased. No significant effect of duration was found on eV latency relative to the last pulse in the train or Na latency relative to the onset of the stimuli.
Behavioral threshold data is consistent with temporal integration of auditory activity. Electrophysiological data indicates that: (a) recognizable EABR and EMLR waveforms can be recorded in response to electrical pulse trains of up to 10 ms; and (b) pulse train stimuli have unique effects on the auditory brainstem compared to thalamo-cortical areas. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Davids, Taryn; Valero, Jerome; Papsin, Blake C.; Harrison, Robert V.; Gordon, Karen A.] Hosp Sick Children, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 1X8, Canada.
[Davids, Taryn; Papsin, Blake C.; Harrison, Robert V.; Gordon, Karen A.] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 2N2, Canada.
RP Davids, T (reprint author), Hosp Sick Children, Dept Otolaryngol Head & Neck Surg, 6th Floor,Elm Wing,555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM taryndavids@hotmail.com
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NR 45
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 7
EP 14
DI 10.1016/j.heares.2008.06.011
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200002
PM 18692121
ER
PT J
AU Davids, T
Valero, J
Papsin, BC
Harrison, RV
Gordon, KA
AF Davids, Taryn
Valero, Jerome
Papsin, Blake C.
Harrison, Robert V.
Gordon, Karen A.
TI Effects of stimulus manipulation on electrophysiological responses of
pediatric cochlear implant users. Part II: Rate effects
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Electrical stimulation; Electrophysiological
thresholds; Behavioral thresholds
ID AUDITORY BRAIN-STEM; ELECTRICAL-STIMULATION; PSYCHOPHYSICAL MEASURES;
FUNCTIONAL-RESPONSES; EVOKED-POTENTIALS; PULSE TRAINS; GUINEA-PIGS;
NERVE; THRESHOLDS; NUCLEUS
AB Electrophysiological thresholds do not accurately predict behavioral thresholds in pediatric cochlear implant users possibly due to differences in rate and duration of pulse presentation. We asked: (1) is there an effect of rate of stimulus presentation on the electrophysiological responses of the auditory brainstem and thalamo-cortex? and (2) can the relationship between electrophysiological and behavioral thresholds be improved by using the same rate of pulse presentation?
Behavioral and electrophysiological (EABR and EMLR) responses were elicited for 14 children to single electrical pulses and pulse trains of 2 ms ranging in rate from 500 to 3600 pulses per second (pps).
Low rate (500 pps) pulse trains resulted in an increase in EABR wave eIII amplitude and a decrease in wave eV amplitude. Further rate increases resulted in smaller EABR wave amplitudes. EMLR amplitudes were unaffected by increases in rate as were EABR and EMLR latencies. Behavioral thresholds decreased with increasing rate, however, there was no associated reduction in electrophysiological thresholds. Correlation between behavioral and electrophysiological thresholds did not improve by using the same rate of electrical pulse stimulation.
Results suggest: (1) higher rates of electrical pulse presentation increase the potential for neural adaptation in the auditory brainstem and (2) using the same rate of electrical pulse presentation does not improve the ability of EABR and EMLR thresholds to predict behavioral thresholds. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Davids, Taryn; Valero, Jerome; Papsin, Blake C.; Harrison, Robert V.; Gordon, Karen A.] Hosp Sick Children, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 1X8, Canada.
[Davids, Taryn; Papsin, Blake C.; Harrison, Robert V.; Gordon, Karen A.] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 2N2, Canada.
RP Davids, T (reprint author), Hosp Sick Children, Dept Otolaryngol Head & Neck Surg, 6th Floor,Elm Wing,555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM taryndavids@hotmail.com
FU Hospital for Sick Children Research Institute
FX This research is supported by the Hospital for Sick Children Research
Institute, there are no conflicts of interest.
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NR 56
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 15
EP 24
DI 10.1016/j.heares.2008.06.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200003
PM 18692122
ER
PT J
AU Agterberg, MJH
Versnel, H
de Groot, JCMJ
Smoorenburg, GF
Albers, FWJ
Klis, SFL
AF Agterberg, Martijn J. H.
Versnel, Huib
de Groot, John C. M. J.
Smoorenburg, Guido F.
Albers, Frans W. J.
Klis, Sjaak F. L.
TI Morphological changes in spiral ganglion cells after intracochlear
application of brain-derived neurotrophic factor in deafened guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE Brain-derived neurotrophic factor; Electron microscopy; Guinea pig;
Perikaryal area; Spiral ganglion cells
ID SENSORINEURAL HEARING-LOSS; CHRONIC ELECTRICAL-STIMULATION; NERVE
GROWTH-FACTOR; COCHLEAR IMPLANTS; AUDITORY NEURONS; INNER-EAR;
TIME-SEQUENCE; IN-VIVO; SURVIVAL; DEGENERATION
AB When guinea pigs are deafened with ototoxic drugs spiral ganglion cells (SGCs) degenerate progressively. Application of neurotrophins can prevent this process. Morphological changes of rescued SGCs have not been quantitatively determined yet. It might be that SGCs treated with neurotrophins are more vulnerable than SGCs in cochleae of normal-hearing guinea pigs. Therefore, the mitochondria. and myelinisation of type-I SGCs were studied and the perikaryal area, cell circularity and electron density were determined. Guinea pigs were deafened with a subcutaneous injection of kanamycin followed by intravenous infusion of furosemide. Brain-derived neurotrophic factor (BDNF) delivery was started two weeks after the deafening procedure and continued for four weeks. Four cohorts of cochleae were studied: (I) cochleae of normal-hearing guinea pigs: (2) of guinea pigs two weeks after deafening; (3) six weeks after deafening; (4) cochleae treated with BDNF after deafening. The deafening procedure resulted in a progressive loss of SGcs. Six weeks after deafening the size of mitochondria, perikaryal area and cell circularity of the remaining untreated SGCs were decreased and the number of layers of the myelin sheath was reduced. In the basal part of the cochlea BDNF treatment rescued SGCs from degeneration. SGCs treated with BDNF were larger than SGCs in normal-hearing guinea pigs, whereas circularity had normal values and electron density was unchanged. The number of layers in the myelin sheath of BDNF-treated SGCs was reduced as compared to the number of layers in the myelin sheath of SGCs in normal-hearing guinea pigs. The morphological changes of SGCs might be related to the rapid loss of SGCs that has been reported to occur after cessation of BDNF treatment. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Agterberg, Martijn J. H.; Versnel, Huib; de Groot, John C. M. J.; Smoorenburg, Guido F.; Albers, Frans W. J.; Klis, Sjaak F. L.] Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands.
RP Agterberg, MJH (reprint author), Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Rudolf Magnus Inst Neurosci, Room G-02-531,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM m.j.h.agterberg@umcutrecht.nl
RI Agterberg, Martijn/K-2956-2012
FU Cochlear(R); Heinsius-Houbolt Foundation
FX The authors thank Kelly Maijoor and Rik Mansvelt-Beck for excellent
technical assistance, Ferry Hendriksen and Frits Meeuwsen for assisting
with histology, and Frank Harriers and Rene van de Vosse for developing
the recording and analysis software. This study was also supported by
Cochlear (R) and the Heinsius-Houbolt Foundation.
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NR 52
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 25
EP 34
DI 10.1016/j.heares.2008.07.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200004
PM 18692557
ER
PT J
AU Marshall, AF
Pearson, JM
Falk, SE
Skaggs, JD
Crocker, WD
Saldana, E
Fitzpatrick, DC
AF Marshall, Allen F.
Pearson, James M.
Falk, Stephanie E.
Skaggs, John D.
Crocker, William D.
Saldana, Enrique
Fitzpatrick, Douglas C.
TI Auditory response properties of neurons in the tectal longitudinal
column of the rat
SO HEARING RESEARCH
LA English
DT Article
DE Midbrain tectum; Inferior colliculus; Superior colliculus;
Periaqueductal gray
ID SUPERIOR OLIVARY COMPLEX; MEDIAL OLIVOCOCHLEAR NEURONS; COCHLEAR ROOT
NEURONS; INFERIOR COLLICULUS NEURONS; AMPLITUDE-MODULATED SOUNDS;
PARAOLIVARY NUCLEUS; LATERAL LEMNISCUS; DORSAL NUCLEUS; CHOLERA-TOXIN;
ALBINO-RAT
AB The newly-discovered tectal longitudinal column (TLC) spans the paramedian region of the mammalian tectum. It has connections with several nuclei of the auditory system. In this report, we provide the first detailed description of the responses of TLC neurons to auditory stimuli, including monaural and binaural tones and amplitude modulated tones. For comparison, responses in the inferior colliculus (IC) were also recorded. Neurons in the TLC were sensitive to similar ranges of frequency as IC neurons, could have comparably low thresholds, and showed primarily excitatory responses to stimulation of the contralateral ear with either phasic or sustained response patterns. Differences of TLC compared to IC neurons included broader frequency tuning, higher average threshold, longer response latencies, little synchronization or rate tuning to amplitude modulation frequency and a smaller degree of inhibition evoked by stimulation of the ipsilateral ear. These features of TLC neurons suggest a role for the TLC in descending auditory pathways. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Marshall, Allen F.; Pearson, James M.; Falk, Stephanie E.; Skaggs, John D.; Crocker, William D.; Fitzpatrick, Douglas C.] Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Neurosci Hosp G0412, Chapel Hill, NC 27599 USA.
[Saldana, Enrique] Univ Salamanca, Dept Pathol & Cell Biol, Neurosci Inst Castilla & Leon INCyL, Lab Neurobiol Hearing, E-37008 Salamanca, Spain.
RP Fitzpatrick, DC (reprint author), Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Neurosci Hosp G0412, CB 7070, Chapel Hill, NC 27599 USA.
EM DCF@med.unc.edu
RI Saldana, Enrique/C-4017-2011; 2008, Ibsal/A-1268-2012
FU NIH [DC-03948]; UNC Medical Alumni Association Endowment Fund; MCyT
[BF12000-1358, BFU2004-05909]; JCyL [SA079/01, SA007C05]
FX Research supported (in part) by NIH Short Term Research Training Grant,
the UNC Medical Alumni Association Endowment Fund, and by NIH Grant
DC-03948 to DCF, and by Grants MCyT (BF12000-1358 and BFU2004-05909) and
JCyL (SA079/01 and SA007CO5) to E.S.
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NR 54
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 35
EP 44
DI 10.1016/j.heares.2008.07.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200005
PM 18662764
ER
PT J
AU Basura, GJ
Abbas, AI
O'Donohue, H
Lauder, JM
Roth, BL
Walker, PD
Manis, PB
AF Basura, Gregory J.
Abbas, Atheir I.
O'Donohue, Heather
Lauder, Jean M.
Roth, Bryan L.
Walker, Paul D.
Manis, Paul B.
TI Ontogeny of serotonin and serotonin(2A) receptors in rat auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE Auditory cortex; High performance liquid chromatography;
Immunocytochemistry; Serotonin; Serotonin(2A) receptors; Autoradiography
ID CENTRAL-NERVOUS-SYSTEM; VISUAL-CORTEX; PREFRONTAL CORTEX;
POSTNATAL-DEVELOPMENT; SOMATOSENSORY CORTEX; INTENSITY DEPENDENCE;
CORTICAL DEVELOPMENT; EVOKED-POTENTIALS; PYRAMIDAL NEURONS;
CEREBRAL-CORTEX
AB Maturation of the mammalian cerebral cortex is, in part, dependent upon multiple coordinated afferent neurotransmitter systems and receptor-mediated cellular linkages during early postnatal development. Given that serotonin (5-HT) is one such system, the present study was designed to specifically evaluate 5-HT tissue content as well as 5-HT2A receptor protein levels within the developing auditory cortex (AC). Using high performance liquid chromatography (HPLC), 5-HT and the metabolite, 5-hydroxyindoleacetic acid (5-HIAA), was measured in isolated AC, which demonstrated a developmental dynamic, reaching young adult levels early during the second week of postnatal development. Radioligand binding of 5-HT2A receptors with the 5-HT2A/2C receptor agonist, I-125-DOI ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl; in the presence of SB206553, a selective 5-HT2C receptor antagonist, also demonstrated a developmental trend, whereby receptor protein levels reached young adult levels at the end of the first postnatal week (138), significantly increased at PI 0 and at PI 7, and decreased back to levels not significantly different from P8 thereafter. Immunocytochemical labeling of 5-HT2A receptors and confocal microscopy revealed that 5-HT2A receptors are largely localized on layer II/III pyramidal cell bodies and apical dendrites within AC. When considered together, the results of the present study suggest that 5-HT, likely through 5-HT2A receptors, may play an important role in early postnatal AC development. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Basura, Gregory J.; O'Donohue, Heather; Manis, Paul B.] Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
[Roth, Bryan L.] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA.
[Lauder, Jean M.] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA.
[Manis, Paul B.] Univ N Carolina, Dept Cell & Mol Physiol & Curriculum Neurobiol, Chapel Hill, NC 27599 USA.
[Walker, Paul D.] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA.
[Abbas, Atheir I.; Roth, Bryan L.] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA.
RP Manis, PB (reprint author), Univ N Carolina, Dept Otolaryngol Head & Neck Surg & Cell & Mol Ph, G127 Phys Off Bldg,CB 7070, Chapel Hill, NC 27599 USA.
EM pmanis@med.unc.edu
RI Roth, Bryan/F-3928-2010
FU Deafness Research Foundation; NIH [T32 GM007250]
FX This work was supported by a grant from the Deafness Research
Foundation. The authors thank Iris Obispo-Peak for performing
5-HT2A immunocytochemistry and confocal imaging and the
reviewers for their helpful comments on an earlier version of this
manuscript. Atheir Abbas was supported in part by NIH T32 GM007250.
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NR 64
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 45
EP 50
DI 10.1016/j.heares.2008.07.009
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200006
PM 18718516
ER
PT J
AU Huang, Y
Huang, Q
Chen, X
Qu, TS
Wu, XH
Li, L
AF Huang, Ying
Huang, Qiang
Chen, Xun
Qu, Tianshu
Wu, Xihong
Li, Liang
TI Perceptual integration between target speech and target-speech
reflection reduces masking for target-speech recognition in younger
adults and older adults
SO HEARING RESEARCH
LA English
DT Article
DE Auditory perception; Energetic masking; Informational masking;
Perceptual integration; Precedence effect; Reverberant environment
ID PERCEIVED SPATIAL SEPARATION; HEARING-LOSS; INFORMATIONAL MASKING; GAP
DETECTION; AUDITORY LOCALIZATION; ENERGETIC MASKING; CHINESE SPEECH;
NEARBY SOURCES; BAND STIMULI; NOISE
AB This study evaluated unmasking functions of perceptual integration of target speech and simulated target-speech reflection, which were presented by two spatially separated loudspeakers. In both younger-adult listeners with normal hearing and older-adult listeners in the early stages of presbycusis, reducing the time interval between target speech and target-reflection simulation (inter-target interval, ITI) from 64 to 0 ms not only progressively enhanced perceptual integration of target-speech signals, but also progressively released target speech from either speech masking or noise masking. When the signal-to-noise ratio was low, the release from speech masking was significantly larger than the release from noise masking in both younger listeners and older listeners, but the longest ITI at which a significant release from speech masking occurred was significantly shorter in older listeners than in younger listeners. These results suggest that in reverberant environments with multi-talker speech, perceptual integration between the direct sound wave and correlated reflections, which facilitates perceptual segregation of various sources, is critical for unmasking attended speech. The age-related reduction of the ITI range for releasing speech from speech masking may be one of the causes for the speech-recognition difficulties experienced by older listeners in such adverse environments. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Huang, Ying; Huang, Qiang; Chen, Xun; Qu, Tianshu; Wu, Xihong; Li, Liang] Peking Univ, Dept Psychol, Speech & Hearing Res Ctr, Key Lab Machine Percept Minist Educ, Beijing 100871, Peoples R China.
RP Li, L (reprint author), Peking Univ, Dept Psychol, Speech & Hearing Res Ctr, Key Lab Machine Percept Minist Educ, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
EM liangli@pku.edu.cn
FU National Natural Science Foundation of China [30711120563, 30670704,
60605016, 60535030, 60435010]; National High Technology Research and
Development Program of China [2006AA01Z196, 2006AA010103]; 2006AA01Z196;
2006AA010103), the Trans-Century Training Program Foundation for the
Talents by the State Education Commission; Peking University
FX This work was supported by the National Natural Science Foundation of
China (30711120563; 30670704; 60605016; 60535030; 60435010), the
National High Technology Research and Development Program of China
(2006AA01Z196; 2006AA010103), the Trans-Century Training Program
Foundation for the Talents by the State Education Commission, and "985"
grants from Peking University.
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NR 44
TC 21
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 51
EP 65
DI 10.1016/j.heares.2008.07.006
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200007
PM 18694813
ER
PT J
AU Morton, KD
Torrione, PA
Throckmorton, CS
Collins, LM
AF Morton, Kenneth D.
Torrione, Peter A., Jr.
Throckmorton, Chandra S.
Collins, Leslie M.
TI Mandarin Chinese tone identification in cochlear implants: Predictions
from acoustic models
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implant; Mandarin Chinese tones; F0 estimation; Particle filter
ID SPEECH CODING STRATEGY; AUDITORY-PERCEPTION; PITCH PERCEPTION;
FINE-STRUCTURE; RECOGNITION; STIMULATION; NOISE; CUES; INFORMATION;
AMPLITUDE
AB It has been established that current cochlear implants do not supply adequate spectral information for perception of tonal languages. Comprehension of a tonal language, such as Mandarin Chinese, requires recognition of lexical tones. New strategies of cochlear stimulation such as variable stimulation rate and current steering may provide the means of delivering more spectral information and thus may provide the auditory fine-structure required for tone recognition. Several cochlear implant signal processing strategies are examined in this study, the continuous interleaved sampling (CIS) algorithm, the frequency amplitude modulation encoding (FAME) algorithm, and the multiple carrier frequency algorithm (MCFA). These strategies provide different types and amounts of spectral information. Pattern recognition techniques can be applied to data from Mandarin Chinese tone recognition tasks using acoustic models as a means of testing the abilities of these algorithms to transmit the changes in fundamental frequency indicative of the four lexical tones. The ability of processed Mandarin Chinese tones to be correctly classified may predict trends in the effectiveness of different signal processing algorithms in cochlear implants. The proposed techniques can predict trends in performance of the signal processing techniques in quiet conditions but fail to do so in noise. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Morton, Kenneth D.; Torrione, Peter A., Jr.; Throckmorton, Chandra S.; Collins, Leslie M.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA.
RP Collins, LM (reprint author), Duke Univ, Dept Elect & Comp Engn, Box 90291, Durham, NC 27708 USA.
EM lcollins@ee.duke.edu
FU NIH [1-R01-DC007994-01]
FX The authors would like to acknowledge Dr. Zeng at the University of
California Irvine for his help in acquiring the speech material used in
this research. They would also like to thank the subjects who
participated in the experiment. This research was supported in part by
NIH Grant 1-R01-DC007994-01.
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NR 54
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 66
EP 76
DI 10.1016/j.heares.2008.07.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200008
PM 18706497
ER
PT J
AU Pretorius, LL
Hanekom, JJ
AF Pretorius, L. L.
Hanekom, J. J.
TI Free field frequency discrimination abilities of cochlear implant users
SO HEARING RESEARCH
LA English
DT Article
DE Cochlear implants; Frequency discrimination; Pure tones; Music
perception
ID NORMALLY HEARING SUBJECTS; DUAL-ELECTRODE STIMULI; PITCH PERCEPTION;
MUSIC PERCEPTION; ELECTRICAL-STIMULATION; TEMPORAL CUES; RECIPIENTS;
RANKING; SPEECH; SOUNDS
AB Poor music perception abilities of cochlear implant users may be attributed to limited pitch resolution afforded by the implant system. We investigated (i) what the typical frequency discrimination thresholds of cochlear implant users would be in free field listening conditions and (ii) whether frequency discrimination behaviour would be influenced by the position of the reference frequency relative to the frequency response of filters selected from the user's map. Frequency discrimination thresholds were determined according to an adaptive two-alternative forced choice (2AFC) method, using pure tones delivered in free field conditions. Results showed that finer frequency resolution than previously thought could be available to cochlear implant users. Results are interpreted in terms of intermediate pitch percepts possibly created by near-simultaneous activation of adjacent electrodes, resulting in overlapping neural populations to be stimulated. The findings may contribute to strategies aiming to improve music perception abilities of cochlear implant users. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Pretorius, L. L.; Hanekom, J. J.] Univ Pretoria, Dept Elect Elect & Comp Engn, ZA-0002 Pretoria, South Africa.
RP Hanekom, JJ (reprint author), Univ Pretoria, Dept Elect Elect & Comp Engn, ZA-0002 Pretoria, South Africa.
EM johan.hanekom@up.ac.za
FU National Research Foundation (South Africa)
FX The authors wish to thank all the participants for their contribution,
P.J. Venter for his contribution towards software development, as well
as two anonymous reviewers for helpful comments. Financial assistance by
the National Research Foundation (South Africa) is acknowledged.
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NR 39
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 77
EP 84
DI 10.1016/j.heares.2008.07.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200009
PM 18692556
ER
PT J
AU Ohlemiller, KK
Rice, MER
Gagnon, PM
AF Ohlemiller, Kevin K.
Rice, Mary E. Rybak
Gagnon, Patricia M.
TI Strial microvascular pathology and age-associated endocochlear potential
decline in NOD congenic mice
SO HEARING RESEARCH
LA English
DT Article
DE Cochlea; Presbycusis; Stria vascularis; Marginal cells; Basal cells;
intermediate cells; Autoimmunity; Capillary
ID NORTH AUTOIMMUNE MOUSE; HEARING-LOSS; INNER-EAR; MRL-FAS(LPR) MOUSE;
AUDITORY DYSFUNCTION; VASCULARIS; DISEASE; HYPERLIPOPROTEINEMIA;
IMMUNOGLOBULIN; CAPILLARIES
AB NOD/ShiLtJ (previously NOD/LtJ) inbred mice show polygenic autoimmune disease and are commonly used to model autoimmune-related type I diabetes, as well as Sjogren's syndrome. They also show rapidly progressing hearing loss, partly due to the combined effects of Cdh23(ahl) and Ahl2. Congenic NOD.NON-H2(nb1)/LtJ mice, which carry corrective alleles within the H2 histocompatibility gene complex, are free from diabetes and other overt signs of autoimmune disease, but still exhibit rapidly progressive hearing loss. Here we show that cochlear pathology in these congenics broadly includes hair cell and neuronal loss, plus endocochlear potential (EP) decline from initially normal values after two months of age. The EP reduction follows often dramatic degeneration of capillaries in stria, vascularis, with resulting strial degeneration. The cochlear modiolus also features perivascular inclusions that resemble those in some mouse autoimmune models. We posit that cochlear hair cell/neural and strial pathology arise independently. While sensory cell loss may be closely tied to Cdh23(ahl) and Ahl2, the strial microvascular pathology and modiolar anomalies we observe may arise from alleles on the NOD background related to immune function. Age-associated EP decline in NOD.NON-H2(nbl) mice may model forms of strial age-related hearing loss caused principally by microvascular disease. The remarkable strial capillary loss in these mice may also be useful for studying the relation between strial vascular insufficiency and strial function. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Ohlemiller, Kevin K.; Gagnon, Patricia M.] Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
[Ohlemiller, Kevin K.; Gagnon, Patricia M.] Washington Univ, Cent Inst Deaf, Fay & Carl Simons Ctr Biol Hearing & Deafness, St Louis, MO 63110 USA.
[Ohlemiller, Kevin K.; Rice, Mary E. Rybak] Washington Univ, Program Audiol & Commun Sci, St Louis, MO 63110 USA.
RP Ohlemiller, KK (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid St, St Louis, MO 63110 USA.
EM kohlemiller@wustl.edu
FU NIH [R01 DC008321, R01 DC03454, P30 DC04665, P30 NS057105]
FX Supported by NIH R01 DC008321 (KKO), R01 DC03454 (KKO), P30 DC04665 (R.
Chole), P30 NS057105 (D. Holtzman), and Washington University Medical
School Department of Otolaryngology. Thanks to Dr. Dennis Trune for
comments on the manuscript.
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NR 52
TC 15
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 85
EP 97
DI 10.1016/j.heares.2008.08.001
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200010
PM 18727954
ER
PT J
AU Berntson, AK
Walmsley, B
AF Berntson, A. K.
Walmsley, B.
TI Characterization of a potassium-based leak conductance in the medial
nucleus of the trapezoid body
SO HEARING RESEARCH
LA English
DT Article
DE Mouse; Two-pore potassium channel; Dynamic clamp; TWIK; Leak
ID DEAFNESS ASSOCIATED CHANGES; MOUSE-BRAIN SLICE; DYNAMIC CLAMP; K+
CHANNEL; EXTRACELLULAR PH; NEURONS; FAMILY; MNTB; EXCITABILITY;
MODULATION
AB Principal neurons of the medial nucleus of the trapezoid body (MNTB) integrate the large, excitatory inputs from anteroventral cochlear nucleus (AVCN) bushy cells with conventional inhibitory inputs to produce an inhibitory output to the lateral and medial superior olive. This circuit is critical in the sound localization pathway of the auditory brainstem. Many ionic currents act in concert to produce the rapid phase-locked firing properties characteristic of MNTB principal neurons. We report here that MNTB neurons of the mouse possess a 2-4 nS instantaneous potassium-based leak current, probably mediated by TWIK two-pore potassium leak channels. The function of the leak current was examined by modulating its magnitude with a dynamic clamp. The leak current modulates the resting voltage by 5 mV/nS, reduces the input resistance of the cell by 5 M Omega/nS and reduces the membrane time constant by 0.075 mu s/nS. The leak current also modulates spike timing. Given leak channels are highly regulated, they are well placed to influence the firing properties, and action potential timing in principal neurons of the MNTB. (C) 2008 Elsevier B.V. All rights reserved
C1 [Berntson, A. K.; Walmsley, B.] Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Acton, ACT 0200, Australia.
RP Berntson, AK (reprint author), Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, GPO Box 4, Acton, ACT 0200, Australia.
EM Amy.Eichner@anu.edu.au
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NR 36
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2008
VL 244
IS 1-2
BP 98
EP 106
DI 10.1016/j.heares.2008.08.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 368XC
UT WOS:000260655200011
PM 18761066
ER
PT J
AU MacDonald, GH
Rubel, EW
AF MacDonald, Glen H.
Rubel, Edwin W.
TI Three-dimensional imaging of the intact mouse cochlea by fluorescent
laser scanning confocal microscopy
SO HEARING RESEARCH
LA English
DT Article
DE fluorescence; confocal; cochlea; refractive index; methyl salicylate;
benzyl benzoate
ID SPIRAL GANGLION NEURONS; MAMMALIAN COCHLEA; ELECTRON-MICROSCOPY; 3D
RECONSTRUCTION; SUPPORTING CELLS; REFRACTIVE-INDEX; HAIR-CELLS;
INNERVATION; ORGAN; CORTI
AB The complex anatomy of the mammalian cochlea is most readily understood by representation in three-dimensions. However, the cochlea is often sectioned to minimize the effects of its anatomic complexity and optical properties on image acquisition by light microscopy. We have found that optical aberrations present in the decalcified cochlea can be greatly reduced by dehydration through graded ethanols followed by clearing with a mixture of five parts methyl salicylate and three parts benzyl benzoate (MSBB). Clearing the cochlea with MSBB enables acquisition of high-resolution images with multiple fluorescent labels, through the full volume of the cochlea by laser scanning confocal microscopy. The resulting images are readily applicable to three-dimensional morphometric analysis and volumetric visualizations. This method promises to be particularly useful for three-dimensional characterization of anatomy, innervation and expression of genes or proteins in the many new animal models of hearing and balance generated by genetic manipulation. Furthermore, the MSBB is compatible with most non-protein fluorophores used for histological labeling, and may be removed with traditional transitional solvents to allow subsequent epoxy embedding for sectioning. (C) 2008 Elsevier B.V. All rights reserved.
C1 [MacDonald, Glen H.; Rubel, Edwin W.] Univ Washington, Virginia Merrill Bloedel Heating Res Ctr, Dept Otolaryngol HNS, Seattle, WA 98195 USA.
RP Rubel, EW (reprint author), Univ Washington, Virginia Merrill Bloedel Heating Res Ctr, Dept Otolaryngol HNS, Box 357923, Seattle, WA 98195 USA.
EM rubel@u.washington.edu
FU NIDCD [DC04661, DC03829]; Foundation Fighting Blindness
[BR-GE-0606-0347]
FX This work was supported by NIDCD grants DC04661 and DC03829, and the
Foundation Fighting Blindness BR-GE-0606-0347.
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NR 31
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2008.05.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900001
PM 18573326
ER
PT J
AU Santi, PA
Rapson, I
Voie, A
AF Santi, Peter A.
Rapson, Ian
Voie, Arne
TI Development of the mouse cochlea database (MCD)
SO HEARING RESEARCH
LA English
DT Article
DE mice; cochlea; atlas; 3D reconstruction; OPFOS
ID MICE
AB The mouse cochlea database (MCD) provides an interactive, image database of the mouse cochlea for learning its anatomy and data mining of its resources. The MCD website is hosted on a centrally maintained, high-speed server at the following URL: http://mousecochlea.umn.edu. The MCD contains two types of image resources, serial 2D image stacks and 3D reconstructions of cochlear structures. Complete image stacks of the cochlea from two different mouse strains were obtained using orthogonal plane fluorescence optical microscopy (OPFOS). 2D images of the cochlea are presented on the MCD website as: viewable images within a stack, 2D atlas of the cochlea, orthogonal sections, and direct volume renderings combined with isosurface reconstructions. In order to assess cochlear structures quantitatively, "true" cross-sections of the scala media along the length of the basilar membrane were generated by virtual resectioning of a cochlea orthogonal to a cochlear structure, such as the centroid of the basilar membrane or the scala media. 3D images are presented on the MCD website as: direct volume renderings, movies, interactive QuickTime VRs, flythrough, and isosurface 3D reconstructions of different cochlear structures. 3D computer models can also be used for solid model fabrication by rapid prototyping and models from different cochleas can be combined to produce an average 3D model. The MCD is the first comprehensive image resource on the mouse cochlea and is a new paradigm for understanding the anatomy of the cochlea, and establishing morphometric parameters of cochlear structures in normal and mutant mice. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Santi, Peter A.; Rapson, Ian] Univ Minnesota, Dept Otolaryngol, Minneapolis, MN 55455 USA.
[Voie, Arne] Spencer Technol, Seattle, WA USA.
RP Santi, PA (reprint author), Univ Minnesota, Dept Otolaryngol, Room 121,Lions Res Bldg,2001 6th St SE, Minneapolis, MN 55455 USA.
EM psanti@umn.edu
FU NIDCD [R21 DC005482, R01 DC007588]; Capita Foundation
FX The authors thank the following students who have worked on the initial
development of the MCD: Viet Pham, Jodi Lukkes, and Ann Schrafnagle, who
did a great deal of structure segmentation. We also thank Tom Forsythe
for work on the Stack Viewer program, and John Purdy for his excellent
work on preliminary development of the 3D coordinate system of the
cochlea. We also thank Dr. Douglas B. Webster of Louisiana State
University the celloidin sections of the mouse cochlea and Dave Hultman
for assistance with the rapid prototyping. Authorship credit follows
ICMJE guidelines (http://www.icmje.org/index.html). Funding for this
research has been provided by the: NIDCD (R21 DC005482; R01 DC007588),
Capita Foundation, and University of Minnesota resources including the:
Digital Technology Center, Supercomputing Institute, and Biomedical
Engineering Institute. P.S. designed the MCD, wrote grants to fund the
project, prepared the images, and wrote the manuscript. AN. performed
the OPFOS imaging and reviewed the manuscript. AN. is an employee of
Spencer Technologies (http://www.spencertechnologies.com).
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NR 19
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 11
EP 17
DI 10.1016/j.heares.2008.04.014
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900002
PM 18603386
ER
PT J
AU Zhang, ZG
Zhang, VW
Chan, SC
McPherson, B
Hu, Y
AF Zhang, Z. G.
Zhang, V. W.
Chan, S. C.
McPherson, B.
Hu, Y.
TI Time-frequency analysis of click-evoked otoacoustic emissions by means
of a minimum variance spectral estimation-based method
SO HEARING RESEARCH
LA English
DT Article
DE click-evoked otoacoustic emissions; minimum variance spectral
estimation; time-frequency analysis; time-frequency resolution; wavelet
transform
ID WAVELET ANALYSIS; NOISE; SYSTEM
AB This paper proposes a new minimum variance spectral estimation (MVSE)-based time-frequency analysis (TFA) technique for click-evoked otoacoustic emissions (CEOAEs). The MVSE is a popular spectrum analysis method which can yield a high frequency resolution compared to other nonparametric spectral analysis procedures. The conventional MVSE is extended to a TFA method by windowing the observation data to obtain a time-frequency representation for the signal under study. Inspired by the adaptive window selection process in wavelet transform and based on the time-frequency characteristics of CECAEs, the window size of the windowed MVSE (WMVSE) is given a small value at high frequencies and a large value at low frequencies. The adaptive window size selection yields the proposed frequency-dependent WMVSE (FDWMVSE). The FDWMVSE method integrates the advantages of the adaptive window selection in wavelet transform with the fine frequency resolution of MVSE. Experimental results show that the FDWMVSE can achieve satisfactory time-frequency resolution and reveal meaningful time-frequency features when applied to synthesized and real CEOAEs. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Zhang, Z. G.; Hu, Y.] Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China.
[Zhang, V. W.; McPherson, B.] Univ Hong Kong, Dept Speech & Hearing Sci, Pokfulam, Hong Kong, Peoples R China.
[Chan, S. C.] Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China.
RP Zhang, ZG (reprint author), Duchess Kent Childrens Hosp, Res Off, 12 Sandy Bay Rd, Pokfulam, Hong Kong, Peoples R China.
EM zgzhang@eee.hku.hk
RI McPherson, Donald/A-3140-2010
FU University Grants Council, Hong Kong [HKU 7434/04M]
FX This study was partially supported by the University Grants Council,
Hong Kong, Grant No. HKU 7434/04M. The authors also thank Dr. C.Q. Chang
for his comments on this manuscript. The authors wish to thank the
reviewers for their useful comments on an earlier version of the
manuscript.
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NR 31
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 18
EP 27
DI 10.1016/j.heares.2008.07.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900003
PM 18662763
ER
PT J
AU Chen, GD
Tanaka, C
Henderson, D
AF Chen, Guang-Di
Tanaka, Chiemi
Henderson, Donald
TI Relation between outer hair cell loss and hearing loss in rats exposed
to styrene
SO HEARING RESEARCH
LA English
DT Article
DE outer hair cell; cochlear amplification; hearing loss; styrene
ototoxicity; rat
ID NOISE-INDUCED HEARING; COCHLEAR AMPLIFIER; CARBON-MONOXIDE; GUINEA-PIG;
MICE; INTERMITTENT; POTENTIATION; OTOTOXICITY; SENSITIVITY; MECHANISMS
AB The relationship between outer hair cell (OHC) loss and cochlear sensitivity is still unclear, because in many animal models there exist surviving but dysfunctional OHCs and also injured/dead inner hair cells (IHC). Styrene is an ototoxic agent, which targets and destroys OHCs starting from the third row to the second and first rows depending on the exposure level. The remaining cells may be less affected. In this experiment, rats were exposed to styrene by gavage at different doses (200-800 mg/kg/day) for varying periods (5 days/week for 3-12 weeks). An interesting finding was that the cochlear sensitivity was not affected in a few rats with all OHCs in the third row being destroyed by styrene. A further loss of OHCs was usually accompanied with a linear input/output (I/O) function of cochlear compound action potentials (CAP), indicating the loss of cochlear amplification. However, normal CAP amplitudes at the highest stimulation level of 90 dB SPL were often observed when all OHCs were destroyed, indicating normal function of the remaining IHCs. The OHC-loss/hearing-loss relation appeared to be a sigmoid-type function. Initially, styrene-induced OHC losses (<33%) did not result in a significant threshold shift. Then CAP threshold shift increased dramatically with OHC loss from 33% to 66%. Then, CAP threshold changed less with OHC loss. The data suggest a tri-modal relationship between OHC loss and cochlear amplification. That is, under the condition that all surviving OHCs are ideally functioning, the cochlear amplifier is not affected until 33% of OHCs are absent, then the gain of the amplifier decreases proportionally with the OHC loss, and at last the amplifier may fail completely when more than 67% of OHCs are lost. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Chen, Guang-Di; Tanaka, Chiemi; Henderson, Donald] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Chen, GD (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM gchen7@buffalo.edu
FU NIOSH [1R0101-1008113-01A1]
FX This study is supported by NIOSH Grant 1R0101-1008113-01A1 The authors
thank Eric Bielefeld for his comments and editorial help.
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NR 35
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 28
EP 34
DI 10.1016/j.heares.2008.05.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900004
PM 18586423
ER
PT J
AU Seluakumaran, K
Mulders, WHAM
Robertson, D
AF Seluakumaran, Kumar
Mulders, Wilhelmina H. A. M.
Robertson, Donald
TI Unmasking effects of olivocochlear efferent activation on responses of
inferior colliculus neurons
SO HEARING RESEARCH
LA English
DT Article
DE guinea pig; auditory midbrain; descending control; masking
ID AUDITORY-NERVE FIBERS; VENTRAL COCHLEAR NUCLEUS; GUINEA-PIG;
ELECTRICAL-STIMULATION; INTENSITY DISCRIMINATION; CONTRALATERAL SOUND;
DECEREBRATE CATS; DYNAMIC-RANGE; MASKED TONES; BRAIN-STEM
AB Behavioural studies suggest a role for the medial olivocochlear (MOC) system in improving detection and discrimination of signals in noise. Physiological studies in the cochlea support this notion, showing unmasking, an improvement of the dynamic range of primary auditory afferents in response to tones in noise after MOC system activation. However, little is known about unmasking effects in higher centres. We investigated the effects of MOC stimulation on the responses of neurons in the guinea pig inferior colliculus to masked tones. In 50% of neurons background noise increased the basal rate and decreased maximum rate, an effect similar to that reported in primary afferents. In 35% of neurons maximum rate was increased by the background noise. Activation of the MOC system caused an increased slope and output dynamic range in the majority of input-output functions. Statistical analysis showed that this increased the discriminability of the tones within the noise. Hence, antimasking effects of olivocochlear activation that have been described in the cochlea can still be observed in the midbrain. However, 27% of neurons showed a variety of effects that have not been described in primary afferents, suggesting involvement of central circuitry in modulating effects of MOC stimulation on higher centres. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Seluakumaran, Kumar; Mulders, Wilhelmina H. A. M.; Robertson, Donald] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Crawley, WA 6009, Australia.
RP Mulders, WHAM (reprint author), Univ Western Australia, Sch Biomed Biomol & Chem Sci, Physiol M311,35 Stirling Highway, Crawley, WA 6009, Australia.
EM kumarselvakumaran@hotmail.com; hmul-ders@cyllene.uwa.edu.au;
drobed@cyllene.uwa.edu.au
RI seluakumaran, kumar/B-3926-2009; SELUAKUMARAN, KUMAR/B-8814-2010
FU National Health and Medical Research Council (Australia); Medical Health
and Research Infrastructure Fund; University of Western Australia
FX K. Seluakumaran was a recipient of an international Postgraduate
Research Scholarship from the Australian government and a University
Postgraduate Award from The University of Western Australia. This work
was supported by grants from the National Health and Medical Research
Council (Australia), the Medical Health and Research Infrastructure Fund
and The University of Western Australia. The authors thank IM Winter for
generous supply of recording microelectrodes and M Lloyd for developing
the Neurosound software.
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NR 63
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 35
EP 46
DI 10.1016/j.heares.2008.05.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900005
PM 18573627
ER
PT J
AU Harris, KC
Mills, JH
He, NJ
Dubno, JR
AF Harris, Kelly C.
Mills, John H.
He, Ning-Ji
Dubno, Judy R.
TI Age-related differences in sensitivity to small changes in frequency
assessed with cortical evoked potentials
SO HEARING RESEARCH
LA English
DT Article
DE aging and cortical potentials; auditory evoked potentials; aging and
frequency discrimination
ID SENSORINEURAL HEARING-LOSS; EVENT-RELATED POTENTIALS; INTENSITY
DISCRIMINATION; NEURAL REPRESENTATION; MISMATCH NEGATIVITY; STIMULUS
FREQUENCY; SPEECH RECOGNITION; ELDERLY PERSONS; OLDER-ADULTS; MODULATION
AB As part of an ongoing study of age-related changes in auditory processing, sensitivity to small changes in frequency were assessed using the cortical auditory evoked potential, P1-N1-132, in younger and older adults with normal hearing. Behavioral measures have shown age-related differences in intensity and frequency discrimination that are larger at lower than higher frequencies. However, substantial individual differences and equivocal results among studies have been reported. This variability may reflect differences in tasks and procedures, as well as subject variables, such as hearing sensitivity and level of attention. To minimize these subject variables, the P1-N1-P2 response was investigated using a passive listening paradigm. Subjects were 10 younger and 10 older adults. The P1-N1-P2 was elicited by a 150-ms change in frequency in otherwise continuous 500-Hz and 3000-Hz pure tones presented at 70dB SPL. P1-N1-P2 threshold was defined as the smallest change in frequency needed to evoke a P1-N1-P2 response. Furthermore, a frequency-dependent aging effect was observed for P1-N1-P2 thresholds, such that older subjects were significantly less sensitive to the frequency change than younger subjects, with significantly larger age-related differences at 500 Hz than at 3000 Hz. Age-related changes in response latencies and amplitude of the P1-N1-P2 response were also evident at 500 and 3000 Hz. These results are consistent with age-related changes in the central auditory system and suggest that changes in frequency discrimination abilities of older adults may be, in part, related to changes in preattentive levels of auditory processing. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Harris, Kelly C.; Mills, John H.; He, Ning-Ji; Dubno, Judy R.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Harris, KC (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA.
EM harriskc@musc.edu
FU NIH/NIDCD [P50 DC00422]; National Center for Research Resources [C06
RR-14516]; National Institutes of Health
FX This investigation was supported by NIH/NIDCD P50 DC00422 and conducted
in a facility constructed with support from Research Facilities
Improvement Program Grant Number C06 RR-14516 from the National Center
for Research Resources, National Institutes of Health. Helpful
contributions from Fu-Shing Lee are gratefully acknowledged. Our
gratitude is also given to the editor Jos Eggermont, Bob Burkard and an
anonymous reviewer for their constructive comments, which greatly
improved this paper.
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NR 51
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 47
EP 56
DI 10.1016/j.heares.2008.05.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900006
PM 18597958
ER
PT J
AU Valero, MD
Pasanen, EG
McFadden, D
Ratnam, R
AF Valero, M. D.
Pasanen, E. G.
McFadden, D.
Ratnam, R.
TI Distortion-product otoacoustic emissions in the common marmoset
(Callithrix jacchus): Parameter optimization
SO HEARING RESEARCH
LA English
DT Article
DE OAE; DPOAE; parameter optimization; primary-tone frequency ratio;
primary-tone level difference; animal model; primate; marmoset
ID MEDIAL BELT REGIONS; ACOUSTIC DISTORTION; AUDITORY-CORTEX; FREQUENCY
RATIO; MACACA-MULATTA; STIMULUS PARAMETERS; BASIC FEATURES;
FINE-STRUCTURE; HUMAN ADULTS; MUTANT MICE
AB Distortion-product otoacoustic emissions (DPOAEs) were measured in a New World primate, the common marmoset (Callithrix jacchus). We determined the optimal primary-tone frequency ratio (f(2)/f(1)) to generate DPOAEs of maximal amplitude between 3 and 24 kHz. The optimal f(2)/f(1), determined by varying f(2)/f(1) from 1.02 to 1.40 using equilevell primary tones, decreased with increasing f(2) frequency between 3 and 17 kHz, and increased at 24 kHz. The optimal f(2)/f(1) ratio increased with increasing primary-tone levels from 50 to 74 dB SPL. When all stimulus parameters were considered, the mean optimal f(2)/f(1) was 1.224-1.226. Additionally, we determined the effect of reducing L(2) below L(1). Decreasing L(2) below L(1) by 0, 5, and 10 dB (f(2)/f(1) = 1.21) minimally affected DPOAE strength. DPOAE levels were stronger in females than males and stronger in the right ear than the left, just as in humans. This study is the first to measure OAEs in the marmoset, and the results indicate that the effect of varying the frequency ratio and primary-tone level difference on marmoset DPOAEs is similar to the reported effects in humans and Old World primates. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Valero, M. D.; Ratnam, R.] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA.
[Pasanen, E. G.; McFadden, D.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
[Pasanen, E. G.; McFadden, D.] Univ Texas Austin, Ctr Perceptual Syst, Austin, TX 78712 USA.
RP Ratnam, R (reprint author), Univ Texas San Antonio, Dept Biol, 1 UTSA Circle, San Antonio, TX 78249 USA.
EM Rama.ratnam@utsa.edu
RI Ratnam, Rama/F-9508-2011
FU Southwest National Primate Research Center (SNPRC); Southwest Foundation
for Biomedical Research in San Antonio; Institute for Aging Research at
UTSA; NIH/NIDCD [R03DC009050]; National Institute of Health/National
Institute of General Medical Sciences Minority Biomedical Research
Support-Research Initiative in Science Enhancement (MBRS-RISE)
[GM60655]; National Institute on Deafness [DC00153]; Communication
Disorders (NIDCD)
FX This work was supported in part by a student internship provided to
M.D.V. at the Southwest National Primate Research Center (SNPRC) at the
Southwest Foundation for Biomedical Research in San Antonio, the
Institute for Aging Research at UTSA, and NIH/NIDCD R03DC009050 (to
R.R). One of the authors (M.D.V) was supported by the National Institute
of Health/National Institute of General Medical Sciences Minority
Biomedical Research Support-Research Initiative in Science Enhancement
(MBRS-RISE) GM60655. Data-acquisition software was written by E.G.P
while supported by research grant DC00153 awarded to D.M. by the
National Institute on Deafness and other Communication Disorders
(NIDCD). We would like to thank the SNPRC for their generous support,
and in particular we thank Donna Layne-Colon and Dr. Suzette Tardif for
their constant encouragement and assistance throughout this work.
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NR 77
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 57
EP 68
DI 10.1016/j.heares.2008.05.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900007
PM 18586424
ER
PT J
AU Stakhovskaya, O
Hradek, GT
Snyder, RL
Leake, PA
AF Stakhovskaya, Olga
Hradek, Gary T.
Snyder, Russell L.
Leake, Patricia A.
TI Effects of age at onset of deafness and electrical stimulation on the
developing cochlear nucleus in cats
SO HEARING RESEARCH
LA English
DT Article
DE onset of deafness; deafening models; cochlear nucleus development;
chronic electrical stimulation
ID AUDITORY BRAIN-STEM; SENSORINEURAL HEARING-LOSS; SPIRAL GANGLION
NEURONS; NEONATAL DEAFNESS; POSTNATAL-DEVELOPMENT;
MORPHOLOGICAL-CHANGES; INFERIOR COLLICULUS; SPEECH-PERCEPTION; GM1
GANGLIOSIDE; CRITICAL PERIOD
AB This study examined the effects of deafness and intracochlear electrical stimulation on the anatomy of the cochlear nucleus (CN) after a brief period of normal auditory development early in life. Kittens were deafened by systemic ototoxic drug injections either as neonates or starting at postnatal day 30. Total CN volume, individual CN subdivision volumes, and cross-sectional areas of spherical cell somata in the anteroventral CN (AVCN) were compared in neonatally deafened and 30-day deafened groups at 8 weeks of age and in young adults after similar to 6 months of electrical stimulation initiated at 8 weeks of age. Both neonatal and early acquired hearing loss resulted in a reduction in CN volume as compared to normal hearing cats. Comparison of 8- and 32-week old groups indicated that the CN continued to grow in both deafened groups despite the absence of auditory input. Preserving normal auditory input for 30 days resulted in a significant increase in both total CN volume and cross-sectional areas of spherical cell somata, as compared to neonatally deafened animals. Restoring auditory input in these developing animals by unilateral intracochlear electrical stimulation did not elicit any difference in CN volume between the two sides, but resulted in 7% larger spherical cell size on the stimulated side. Overall, the brief period of normal auditory development and subsequent electrical stimulation maintained CN volume at 80% of normal and spherical cell size at 86% of normal ipsilateral to the implant as compared to 67% and 74%, respectively, in the neonatally deafened group. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Stakhovskaya, Olga; Hradek, Gary T.; Snyder, Russell L.; Leake, Patricia A.] Univ Calif San Francisco, Epstein Lab, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA.
RP Stakhovskaya, O (reprint author), Univ Calif San Francisco, Epstein Lab, Dept Otolaryngol Head & Neck Surg, 533 Parnassus Ave,Room U490, San Francisco, CA 94143 USA.
EM ostakhovskaya@ohns.ucsf.edu
FU National Institutes of Health, and Hearing Research, Inc [N01-DC-3-1006,
HHS-N-263-2007-000540]; [5R01-DC00160]
FX This research was supported by Grant 5R01-DC00160 and Contracts
N01-DC-3-1006 and #HHS-N-263-2007-000540 C from the National Institute
on Deafness and Other Communication Disorders of the National Institutes
of Health, and Hearing Research, Inc. The authors gratefully acknowledge
the expert technical assistance of Steve Rebscher, who designed and
fabricated the custom feline cochlear implants used in this study, and
Beth Dwan who assisted in animal surgery, daily stimulation, and care of
chronically implanted animals.
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NR 53
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 69
EP 77
DI 10.1016/j.heares.2008.05.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900008
PM 18590947
ER
PT J
AU Dai, C
Gan, RZ
AF Dai, Chenkai
Gan, Rong Z.
TI Change of middle ear transfer function in otitis media with effusion
model of guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE middle ear mechanics; otitis media with effusion; laser measurement;
guinea pig
ID FLACCIDA DISPLACEMENT PATTERN; PARS FLACCIDA; TYMPANIC MEMBRANE; STATIC
PRESSURE; INTERFEROMETRY MEASUREMENTS; MUCOCILIARY PATHOLOGY;
KLEBSIELLA-PNEUMONIAE; TEMPORAL BONES; GERBIL; LIPOPOLYSACCHARIDE
AB Otitis media with effusion (OME) is an inflammatory disease of the middle ear that causes most cases of conductive hearing loss observed in the pediatric population. With the long term goal of evaluating middle ear function with OME, the aim of the current study was to create an animal model of OME in which middle ear transfer functions could be measured. In guinea pigs, OME was created by injecting lipopolysaccharide (LPS) into the middle ear. Evidence of OME was assessed by otoscopy, tympanometry, histology, and by measuring the volume of fluid in the middle ear. Vibrations of the umbo and round window membrane were measured with a laser Doppler vibrometer at frequency range of 200-40 kHz in three groups of 3,7, and 14 days after injection of LPS. Changes in displacement of the umbo and round window membrane in response to 80 dB SPL sound in the ear canal were measured across the frequency range. Displacement of both the umbo and round window membrane was reduced at all time points following LPS injections. Further, the change of the displacement transmission ratio (DTR) from the tympanic membrane to the round window occurred mainly in chronic (e.g. 14 days post-LPS injection) OME ears. This study provides useful data for analyzing the change of middle ear transfer function in OME ears. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Oklahoma, Sch Aerosp & Mech Engn, Norman, OK 73019 USA.
Univ Oklahoma, Ctr Bioengn, Norman, OK 73019 USA.
RP Gan, RZ (reprint author), Univ Oklahoma, Sch Aerosp & Mech Engn, 865 Asp Ave,Room 200, Norman, OK 73019 USA.
EM rgan@ou.edu
RI dai, chenkai/A-8051-2010
FU Oklahoma Center for the Advancement of Science Technology [HR06-036];
NIH/NIDCD [RO1DC006632]
FX This work was supported by Oklahoma Center for the Advancement of
Science & Technology (HR06-036) and NIH/NIDCD RO1DC006632. The authors
thank Don Nakmali at Hough Ear Institute for his expert technical
assistance. We thank Dr. Ann Thompson at Health Sciences Center,
University of Oklahoma for instruction of histology study and many
useful suggestions to improve this paper. The authors want to thank the
anonymous reviewers for their tremendous efforts to make this paper
better understandable.
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NR 22
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 78
EP 86
DI 10.1016/j.heares.2008.05.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900009
PM 18586077
ER
PT J
AU Sha, SH
Kanicki, A
Dootz, G
Talaska, AE
Halsey, K
Dolan, D
Altschuler, R
Schacht, J
AF Sha, Su-Hua
Kanicki, Ariane
Dootz, Gary
Talaska, Andra E.
Halsey, Karin
Dolan, David
Altschuler, Richard
Schacht, Jochen
TI Age-related auditory pathology in the CBA/J mouse
SO HEARING RESEARCH
LA English
DT Article
DE age-related hearing loss; presbycusis; hair cells; stria vascularis;
endocochlear potential; spiral ganglion neurons
ID SENSORINEURAL HEARING-LOSS; INBRED STRAINS; OLD GERBILS; MICE; YOUNG;
DEGENERATION; SENSITIVITY; POTASSIUM; GENOTYPES; C57BL/6J
AB Commercially obtained aged male CBA/J mice presented a complex pattern of hearing loss and morphological changes. A significant threshold shift in auditory brainstem responses (ABR) occurred at 3 months of age at 4 kHz without apparent loss of hair cells, rising slowly at loiter ages accompanied by loss of apical hair cells. A delayed high-frequency deficit started at 24 kHz around the age of 12 months. At 20-26 months, threshold shifts at 12 and 24 kHz and the accompanying hair cell loss at the base of the cochlea were highly variable with some animals appearing almost normal and others showing large deficits. Spiral ganglion cells degenerated by 18 months in all regions of the cochlea, with cell density reduced by approximately 25%. There was no degeneration of the stria vascularis and the endocochlear potential remained stable from 3 to 25 months of age regardless of whether the animals had normal or highly elevated ABR thresholds. The slow high-frequency hearing loss combined with a modest reduction of ganglion cell density and an unchanged endocochlear potential suggest sensorineural presbycusis. The superimposed early hearing loss at low frequencies, which is not seen in animals bred in-house, may complicate the use of these animals as a presbycusis model. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Sha, Su-Hua; Kanicki, Ariane; Dootz, Gary; Talaska, Andra E.; Halsey, Karin; Dolan, David; Altschuler, Richard; Schacht, Jochen] Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
RP Sha, SH (reprint author), Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM shasha@umich.edu
FU National Institute on Aging [AG-025164]; National institute on Deafness
[P30 DC-05188]; Other Communication Disorders, NIH
FX This study was supported by program project grant AG-025164 from the
National Institute on Aging and core grant P30 DC-05188 from the
National institute on Deafness and Other Communication Disorders, NIH.
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NR 32
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 87
EP 94
DI 10.1016/j.heares.2008.06.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900010
PM 18573325
ER
PT J
AU Poznyakovskiy, AA
Zahnert, T
Kalaidzidis, Y
Schmidt, R
Fischer, B
Baumgart, J
Yarin, YM
AF Poznyakovskiy, Anton A.
Zahnert, Thomas
Kalaidzidis, Yannis
Schmidt, Rolf
Fischer, Bjoern
Baumgart, Johannes
Yarin, Yury M.
TI The creation of geometric three-dimensional models of the inner ear
based on micro computer tomography data
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; image reconstruction; anisotropic diffusion; active contours;
3-D visualization
ID GUINEA-PIG; ALGORITHM; COCHLEA; IMAGES; RECONSTRUCTION; SEGMENTATION;
SPACE; ORGAN; CORTI; SNAKE
AB The modeling of the mechanical process of hearing requires an accurate geometrical model of the inner ear (cochlea). The purpose of this study was the creation of a 3-D model of the fluid chambers of Guinea pig cochlea, which could serve as a basis for further mechanical modeling. Micro computer tomography used in this study is a noninvasive method to visualize bony structures. The visualization of the membranous labyrinth was achieved by additional staining of the specimen with OSO4. The resulting stack of images has been transformed into a cylindrical coordinate system. To suppress noise on tomography images, a nonlinear smoothing method, anisotropic diffusion, Were applied. A new approach has been proposed to estimate algorithm parameters automatically. Then, a segmentation using active contours (snakes) was performed. In this study, a new energy linking the contours on adjacent slices has been added to the standard approach. This compensates the inconsistencies between adjacent contours. The images segmented in this way were used as a basis for a 3-D reconstruction of the hearing organ. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Poznyakovskiy, Anton A.; Zahnert, Thomas; Yarin, Yury M.] Univ Klinikum Dresden, Dept Med, Otorhinolaryngol Clin, D-01307 Dresden, Germany.
[Kalaidzidis, Yannis] Max Planck Inst Mol & Cell Biol, D-01307 Dresden, Germany.
[Schmidt, Rolf] Tech Univ Dresden, Dept Mech Engn, Inst Solid Mech, D-01307 Dresden, Germany.
[Fischer, Bjoern] Dresden Branch IZFP, Fraunhofer Inst Nondestruct Testing, D-01109 Dresden, Germany.
[Baumgart, Johannes] Tech Univ Dresden, Dept Mech Engn, Inst Aerosp Engn, D-01307 Dresden, Germany.
[Kalaidzidis, Yannis] Moscow MV Lomonosov State Univ, Belozersky Inst Phys Chem Biol, Moscow 117189, Russia.
RP Yarin, YM (reprint author), Univ Klinikum Dresden, Dept Med, Otorhinolaryngol Clin, Fetscherstr 74, D-01307 Dresden, Germany.
EM kalaidzi@mpi-cbg.de; rolf.schmidt@tu-dres-den.de;
bjoern.fischer@izfp-d.fraunhofer.de; johannes.baumgart@tu-dresden.de;
yury.yarin@uniklinikum-dresden.de
RI Baumgart, Johannes/A-8547-2011
OI Baumgart, Johannes/0000-0001-7384-5715
FU DFG [ZA 249/4-2, HA 2075/9-2, GR 1388/14-2]
FX We would like to acknowledge the kind assitance of Peter Kruger,
Fraunhofer-Institut fur Zerstorungsfreie Pruverfahren (IZFP), with
micro-CT recordings, and Brigitte Harmann, Institut fur Pathologie,
Universitatsklinikum Dresden, with staining of specimens. This work was
supported by the DFG, ZA 249/4-2, HA 2075/9-2, GR 1388/14-2.
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NR 28
TC 20
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 95
EP 104
DI 10.1016/j.heares.2008.06.008
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900011
PM 18625296
ER
PT J
AU Friedland, DR
Eernisse, R
Popper, P
AF Friedland, David R.
Eernisse, Rebecca
Popper, Paul
TI Identification of a novel Vamp1 splice variant in the cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE cochlear nucleus; synaptic vesicle; Vamp1; splice variant; auditory
ID MEMBRANE PROTEIN-1 VAMP-1; GENE-EXPRESSION; NERVOUS-SYSTEM; RAT-BRAIN;
PHOSPHORYLATION; SYNAPTOBREVIN; PATTERNS; ISOFORMS; DORSAL; MICE
AB Cochlear nucleus neurons propagate auditory impulses to higher brain stem centers at rapid firing rates with high fidelity. Intrinsic to synaptic transmission are the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins engaged in vesicle fusion, release and recycling. Herein we report a novel splice variant of the SNARE protein Vamp1 (vesicle-associated membrane protein 1) within the cochlear nucleus. We previously demonstrated, through serial analysis of gene expression and microarray studies, that Vamp1 is differentially expressed among the subdivisions of the rat cochlear nucleus. The 3' end of this transcript, however, was poorly characterized and we could not initially confirm our findings. In this study, we designed RT-PCR primers using conserved 5' regions and the mouse 3' domain to validate the expression of Vamp1. Several species of Vamp] were subsequently amplified from a rat brain cDNA library including a full length clone of Vamp1as and a novel splice variant we termed Vamp1nv. Using regional brain libraries Vamp1nv showed expression in the medulla and lack of expression in the cortex, cerebellum and thalamus. Expression of Vamp1nv was further confirmed and characterized by RT-PCR and real-time PCR in each of the cochlear nucleus subdivisions. The predicted protein sequence for Vamp1nv demonstrates a unique modification of the carboxy-terminal end of the protein as compared to known variants. This includes the appearance of two intra-vesicular serine residues with high predicted potential as kinase phosphorylation sites. Such splice variants of Vamp1 may alter the kinetics of SNARE complex formation and vesicle release and impart unique features to expressing neurons. This may be important for central auditory function and contribute to the distinct physiological properties observed in auditory neurons. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Friedland, David R.; Eernisse, Rebecca; Popper, Paul] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
RP Friedland, DR (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM dfriedla@mcw.edu
FU NIH [K08 DC006227]; National Institute on Deafness and Communication
Disorders
FX The authors thank Dr. Joseph Cioffi for his expertise and assistance
throughout this study. We also thank Christy Erbe for technical
assistance. Supported by NIH Grant K08 DC006227 from the National
Institute on Deafness and Communication Disorders.
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NR 28
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 105
EP 112
DI 10.1016/j.heares.2008.06.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900012
PM 18655825
ER
PT J
AU Remijn, GB
Perez, E
Nakajima, Y
Ito, H
AF Remijn, Gerard B.
Perez, Elvira
Nakajima, Yoshitaka
Ito, Hiroyuki
TI Frequency modulation facilitates (modal) auditory restoration of a gap
SO HEARING RESEARCH
LA English
DT Article
DE frequency modulated sound; steady-state sound; auditory restoration;
sound edge; binding
ID ILLUSORY CONTINUITY; TONE COMPONENTS; CORTEX; SOUNDS; PERCEPTION;
PATTERNS; ONSETS; GLIDES; LEVEL; NOISE
AB In this study we further investigated processes of auditory restoration (AR) in recently described stimulus types: the so-called gap-transfer stimulus, the shared-gap stimulus and the pseudo-continuous stimulus. The stimuli typically consist of two crossing sounds of unequal duration. In the shared-gap and pseudocontinuous stimuli, the two crossing sounds share a gap (<45 ms) at their crossing point. In the gap-transfer stimulus, only the long sound contains a gap (100 ms), whereas the short sound is physically continuous. Earlier research has shown that in these stimuli the long sound is subject to AR, in spite of the gap it contains, whereas the gap is perceived in the short sound. Experiment 1 of the present study showed that AR of the stimuli's long sound was facilitated when its slope increased from 0 to 1 oct/s. Experiment 2 showed that the effect of slope on AIR of the long sound also occurred when the slope relationship between the long and short sound was fixed. Implications for a tentative sound edge-binding explanation of AR as well as alternative explanations for the effect of slope on AR are discussed. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Remijn, Gerard B.] Kanazawa Univ, Fac Letters, Dept Psychol, Kanazawa, Ishikawa 9201192, Japan.
[Perez, Elvira; Nakajima, Yoshitaka] Kyushu Univ, Fac Design, Dept Acoust Design, Fukuoka 8150033, Japan.
[Ito, Hiroyuki] Kyushu Univ, Fac Design, Dept Visual Commun Design, Fukuoka 8150033, Japan.
RP Remijn, GB (reprint author), Kanazawa Univ, Fac Letters, Dept Psychol, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan.
EM remijn@staff.kanazawa-u.ac.jp; perez.elvira@googlemail.com;
nakajima@design.kyushu-u.ac.jp; ito@design.kyushu-u.ac.jp
FU Japan Society for the Promotion of Science [17-81005280, 1806800,
19103003]
FX This study was supported by Grants-in-Aid provided by the Japan Society
for the Promotion of Science (17-81005280 to HI and GBR in fiscal
2006-2007; 1806800 and 19103003 to YN in fiscal 2007). Further support
came from Kyushu University's and Kanazawa University's COE Program. We
thank two anonymous reviewers, Takayuki Sasaki and Gert ten Hoopen for
their comments and advice on the project, and the students at Kyushu
University for their participation in the experiments.
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NR 28
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 113
EP 120
DI 10.1016/j.heares.2008.06.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900013
PM 18620037
ER
PT J
AU Berkingali, N
Warnecke, A
Gomes, P
Paasche, G
Tack, J
Lenarz, T
Stover, T
AF Berkingali, Nurdanat
Warnecke, Athanasia
Gomes, Priya
Paasche, Gerrit
Tack, Jan
Lenarz, Thomas
Stoever, Timo
TI Neurite outgrowth on cultured spiral ganglion neurons induced by
erythropoietin
SO HEARING RESEARCH
LA English
DT Article
DE EPO; BDNF; spiral ganglion neurons; neurite outgrowth; neuroprotection
ID NEUROTROPHIC FACTOR; INDUCED APOPTOSIS; INNER-EAR; SURVIVAL; EXPRESSION
AB The morphological correlate of deafness is the loss of hair cells with subsequent degeneration of spiral ganglion neurons (SGN). Neurotrophic factors have a neuroprotective effect, and especially brain-derived neurotrophic factor (BDNF) has been demonstrated to protect SGN in vitro and after ototoxic trauma in vivo. Erythropoietin (EPO) attenuates hair cell loss in rat cochlea explants that were treated with gentamycin. Recently, it has also been shown that EPO reduces the apoptose rate in hippocampal neurons. Therefore, the aim of the study was to examine the effects of EPO on SGN in vitro. Spiral ganglion cells were isolated from neonatal rats and cultured for 48 h in serum-free medium supplemented with EPO and/or BDNF. Results showed that survival rates of SGN were not significantly improved when cultivated with EPO alone. Also, EPO did not further increase BDNF-induced survival of SGN. However, significant elongation of neurites was determined when SGN were cultivated with EPO alone. Even though a less than additive effect was observed, combined treatment with BDNF and EPO led to a significant elongation of neurites when compared to individual treatment with BDNF or EPO. It can be concluded that EPO induces neurite outgrowth rather than promoting survival. Thus, EPO presents as an interesting candidate to enhance and modulate the regenerative effect of BDNF on SGN. Crown Copyright (C) 2008 Published by Elsevier B.V. All rights reserved.
C1 [Berkingali, Nurdanat; Warnecke, Athanasia; Gomes, Priya; Paasche, Gerrit; Lenarz, Thomas; Stoever, Timo] Hannover Med Sch, Dept Otorhinolaryngol Head & Neck Surg, D-30625 Hannover, Germany.
[Gomes, Priya; Tack, Jan] Katholieke Univ Leuven, Ctr Gastroenterol Res, B-3000 Louvain, Belgium.
[Gomes, Priya] Funds Sci Res FWO, Flanders, Belgium.
RP Stover, T (reprint author), Hannover Med Sch, Dept Otorhinolaryngol Head & Neck Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM warnecke.athanasia@mh-hannover.de; Stoever.Timo@mh-hannover.de
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NR 20
TC 21
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2008
VL 243
IS 1-2
BP 121
EP 126
DI 10.1016/j.heares.2008.07.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 355NF
UT WOS:000259714900014
PM 18672044
ER
PT J
AU Wilson, BS
Dorman, MF
AF Wilson, Blake S.
Dorman, Michael F.
TI Cochlear implants: A remarkable past and a brilliant future
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Cochlear Implants and Related Sciences
CY JUN 14-17, 2006
CL Vienna, AUSTRIA
DE auditory prosthesis; cochlear implant; cortical plasticity; deafness;
electrical stimulation; hearing; neural prosthesis; speech perception
ID SPEECH CODING STRATEGY; ELECTRIC-ACOUSTIC STIMULATION; SPIRAL GANGLION
NEURONS; CROSS-MODAL PLASTICITY; AUDITORY-SYSTEM; PITCH PERCEPTION;
FUNDAMENTAL-FREQUENCY; CORTICAL PLASTICITY; MELODY RECOGNITION;
NERVE-STIMULATION
AB The aims of this paper are to (i) provide a brief history of cochlear implants; (ii) present a status report on the current state of implant: engineering and the levels of speech understanding enabled by that engineering; (iii) describe limitations of current signal processing strategies: and (iv) suggest new directions for research. With current technology the "average" implant patient, when listening to predictable conversations in quiet, is able to communicate with relative ease. However, in an environment typical of a workplace the average patient has a great deal of difficulty. Patients who are "above average" in terms of speech understanding, can achieve 100% correct scores on the most difficult tests of speech understanding in quiet but also have significant difficulty when signals are presented in noise. The major factors in these outcomes appear to be (i) a loss of low-frequency, fine structure information possibly due to the envelope extraction algorithms common to cochlear implant signal processing; (ii) a limitation in the number of effective channels of stimulation due to overlap in electric fields from electrodes; and (iii) central processing deficits, especially for patients with poor speech understanding. Two recent developments, bilateral implants and combined electric and acoustic stimulation, have promise to remediate some of the difficulties experienced by patients in noise and to reinstate low-frequency fine structure information. If other possibilities are realized, e.g., electrodes that emit drugs to inhibit cell death following trauma and to induce the growth of neurites toward electrodes, then the future is very bright indeed. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Wilson, Blake S.] Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Durham, NC 27710 USA.
[Dorman, Michael F.] Arizona State Univ, Dept Speech & Hearing Sci, Tempe, AZ 85287 USA.
RP Wilson, BS (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Durham, NC 27710 USA.
EM blake.wilson@duke.edu
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NR 163
TC 155
Z9 157
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 3
EP 21
DI 10.1016/j.heares.2008.06.005
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000002
PM 18616994
ER
PT J
AU Wise, KD
Bhatti, PT
Wang, JB
Friedrich, CR
AF Wise, Kensall D.
Bhatti, Pamela T.
Wang, Jianbai
Friedrich, Craig R.
TI High-density cochlear implants with position sensing and control
SO HEARING RESEARCH
LA English
DT Article
DE high-density cochlear electrodes; MEMS; cochlear position sensing;
dynamic insertion control; thin-film cochlear arrays
ID CHRONIC ELECTRICAL-STIMULATION; INTRACOCHLEAR POSITION; AUDITORY
PROSTHESES; INSERTION TRAUMA; ELECTRODE ARRAY; TEMPORAL CUES;
RECOGNITION; SYSTEM; PERCEPTION; NERVE
AB Silicon-based thin-film technology has been used to develop high-density cochlear electrode arrays with up to 32 sites and four parallel channels of simultaneous stimulation. The lithographically-defined arrays utilize a silicon-dielectric-metal-parylene structure with 180 mu m-diameter IrO sites on 250 mu m centers. Eight on-board strain gauges allow real-time imaging of array shape during insertion, and a tip sensor measures forces on any structures contacted in the scala tympani (e.g., the basilar membrane). The array can be pre-stressed to hug the modiolus, which provides position reference. Tip position can be resolved to better than 50 mu m. Circuitry mounted on the base of the array generates stimulating currents, records intra-cochlear responses and position information, and interfaces with a custom microcontroller and inductively-coupled wireless interface over an eight-lead ribbon cable. The circuitry delivers biphasic 500 mu A current pulses with 4 mu A resolution and a minimum pulse width of 4 mu s. Multiple sites can be driven in parallel to provide higher current levels. Backing structures and articulated insertion tools are being developed for dynamic closed-loop insertion control. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Wise, Kensall D.; Bhatti, Pamela T.; Wang, Jianbai] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA.
[Wise, Kensall D.; Bhatti, Pamela T.; Wang, Jianbai; Friedrich, Craig R.] Wireless Integrated Microsyst, Engn Res Ctr, Ann Arbor, MI 48109 USA.
[Friedrich, Craig R.] Michigan Technol Univ, Dept Mech Engn & Engn Mech, Houghton, MI 49931 USA.
RP Wise, KD (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, 2401 EECS Bldg,1301 Beal Ave, Ann Arbor, MI 48109 USA.
EM wise@eecs.umich.edu; pamela.bhatti@ece.gate-ch.edu; jianbaiw@ti.com;
craig@mtu.edu
FU National Science Foundation [EEC-9986866]
FX The authors are grateful to S. Lee and I. Bhatti for design support; M.
Gulari, and K. Beach for assistance with array fabrication; A. Sodagar,
B. Casey, and J. Hetke for work on system assembly; R. Tewari for his
work on backing devices; and R. Gordenker, A. Sodagar, C. Ellinger, B.
Pfingst, R. Snyder, and J. Middlebrooks for help with in vitro and in
vivo testing. This work was supported by the National Science Foundation
under cooperative agreement EEC-9986866 and by a gift from the late Ms.
Polly V. Anderson of Cupertino, CA.
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NR 39
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 22
EP 30
DI 10.1016/j.heares.2008.04.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000003
PM 18495392
ER
PT J
AU Anderson, DJ
AF Anderson, David J.
TI Penetrating multichannel stimulation and recording electrodes in
auditory prosthesis research
SO HEARING RESEARCH
LA English
DT Article
DE multichannel electrode arrays; neural stimulation; single unit
recordings; array data processing
ID INDEPENDENT COMPONENT ANALYSIS; STOCHASTIC POINT PROCESSES;
COCHLEAR-IMPLANT STIMULI; NEURONAL SPIKE TRAINS; MICROELECTRODE ARRAYS;
INFERIOR COLLICULUS; CEREBRAL-CORTEX; THIN-FILM; CORTICAL IMAGES; UNIT
RECORDINGS
AB Microelectrode arrays offer the auditory systems physiologists many opportunities through a number of electrode technologies. In particular, silicon substrate electrode arrays offer a large design space including choice of layout plan, range of surface areas for active sites, a choice of site materials and high spatial resolution. Further, most designs can double as recording and stimulation electrodes in the same preparation. Scala tympani auditory prosthesis research has been aided by mapping electrodes in the cortex and the inferior colliculus to assess the CNS responses to peripheral stimulation. More recently silicon stimulation electrodes placed in the auditory nerve, cochlear nucleus and the inferior colliculus have advanced the exploration of alternative stimulation sites for auditory prostheses. Multiplication of results from experimental effort by simultaneously stimulating several locations, or by acquiring several streams of data synchronized to the same stimulation event, is a commonly sought after advantage. Examples of inherently multichannel functions which are not possible with single electrode sites include (I) current steering resulting in more focused stimulation, (2) improved signal-to-noise ratio (SNR) for recording when noise and/or neural signals appear on more than one site and (3) current source density (CSD) measurements. Still more powerful are methods that exploit closely-spaced recording and stimulation sites to improve detailed interrogation of the surrounding neural domain. Here, we discuss thin-film recording/stimulation arrays on silicon substrates. These electrode arrays have been shown to be valuable because of their precision coupled with reproducibility in an ever expanding design space. The shape of the electrode substrate can be customized to accommodate use in cortical, deep and peripheral neural structures while flexible cables. fluid delivery and novel coatings have been added to broaden their application. The use of iridium oxide as the neural interface site material has increased the efficiency of charge transfer for stimulation and lowered impedance for recording electrodes. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Anderson, DJ (reprint author), Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM dja@umich.edu
FU NIH
FX Although this paper was not supported by any specific award, the author
wishes to thank the NIH for the many years of development support for
the Michigan probe through the NINDS's Neuroprosthesis Program and ten
years of P41 support for the University of Michigan Center for Neural
Communications Technology from NCRR and NIBIB. It should be noted that
the author is a principle of NeuroNexus Technologies of Ann Arbor and
stands to benefit financially from investigator use of the electrodes
described herein.
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NR 78
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 31
EP 41
DI 10.1016/j.heares.2008.01.010
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000004
PM 18343062
ER
PT J
AU Richter, CP
Bayon, R
Izzo, AD
Otting, M
Suh, E
Goyal, S
Hotaling, J
Walsh, JT
AF Richter, Claus-Peter
Bayon, Rodrigo
Izzo, Agnella D.
Otting, Margarete
Suh, Eul
Goyal, Sheila
Hotaling, Jeffrey
Walsh, Joseph T., Jr.
TI Optical stimulation of auditory neurons: Effects of acute and chronic
deafening
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; cochlear implants; deafening; optical stimulation; spatial
selectivity
ID ELECTRICAL-STIMULATION; NERVE; EXCITATION; RESOLUTION; COCHLEA
AB In developing neural prostheses, particular success has been realized with cochlear implants. These devices bypass damaged hair cells in the auditory system and electrically stimulate the auditory nerve directly. In contemporary cochlear implants, however, the injected electric current spreads widely along the scala tympani and across turns. Consequently, stimulation of spatially discrete spiral ganglion cell populations is difficult. In contrast to electrical stimulation, it has been shown that extremely spatially selective stimulation is possible using infrared radiation (e.g. [Izzo, A.D., Su, H.S., Pathria, J., Walsh Jr., J.T., Whitlon, D.S., Richter, C.-P., 2007a. Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli. J. Biomed. Opt. 12, 1-7]). Here, we explore the correlation between surviving spiral ganglion cells, following acute and chronic deafness induced by neomycin application into the middle ear, and neural stimulation using optical radiation and electrical current.
In vivo experiments were conducted in gerbils. Before the animals were deafened, acoustic thresholds were obtained and neurons were stimulated with optical radiation at various pulse durations, radiation exposures, and pulse repetition rates. In one group of animals, measurements were made immediately after deafening, while the other group was tested at least four weeks after deafening. Deafness was confirmed by measuring acoustically evoked compound action potentials. Optically and electrically evoked compound action potentials and auditory brainstem responses were determined for different radiation exposures and for different electrical current amplitudes, respectively. After completion of the experiments, the animals were euthanized and the cochleae were harvested for histology.
Acoustically evoked compound action potential thresholds were elevated by more than 40 dB after neomycin application in acutely deaf and more than 60 dB in chronically deaf animals. Compound action potential thresholds, which were determined with optical radiation pulses, were not significantly elevated in acutely deaf animals. However, in chronically deaf animals optically evoked CAP thresholds were elevated. Changes correlated with the number of surviving spiral ganglion cells and the optical parameters that were used for stimulation. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Richter, Claus-Peter] Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol, Chicago, IL 60611 USA.
[Izzo, Agnella D.; Walsh, Joseph T., Jr.] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA.
[Richter, Claus-Peter] Northwestern Univ, Dept Commun Sci & Disorders, Auditory Physiol Lab, Hugh Knowles Ctr, Evanston, IL 60208 USA.
RP Richter, CP (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol, Searle Bldg 12-470,303 E Chicago Ave, Chicago, IL 60611 USA.
EM cri529@northwestern.edu
RI Walsh, Joseph/B-7636-2009
FU National Institute of Deafness and Other Communication Disorders;
National Institutes of Health; Department of Health and Human Services
[HHSN260-2006-00006-C/NIH, No. NO1-DC-6-0006]
FX This project has been funded with Federal funds from the National
Institute of Deafness and Other Communication Disorders, National
Institutes of Health, Department of Health and Human Services, under
Contract Nos. HHSN260-2006-00006-C/NIH No. NO1-DC-6-0006.
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WC Audiology & Speech-Language Pathology; Neurosciences;
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SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000005
PM 18321670
ER
PT J
AU Middlebrooks, JC
Snyder, RL
AF Middlebrooks, John C.
Snyder, Russell L.
TI Intraneural stimulation for auditory prosthesis: Modiolar trunk and
intracranial stimulation sites
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; cat; cochlear implant; cochlear nerve; intracranial;
inferior colliculus
ID PENETRATING ELECTRODE ARRAY; COCHLEAR IMPLANT SUBJECTS; SUPERIOR OLIVARY
COMPLEX; ELECTRICAL-STIMULATION; NERVE-STIMULATION; CHANNEL
INTERACTIONS; GUINEA-PIG; CAT; RECOGNITION; ORGANIZATION
AB We have demonstrated recently in an animal model that stimulation with a penetrating auditory nerve electrode array is a feasible means of activating the ascending auditory pathway for auditory prosthesis. Compared to a conventional intrascalar cochlear implant, intraneural stimulation provides access to fibers serving a broader frequency range, activation of more tonotopically restricted fiber populations, lower thresholds, and reduced interference between simultaneously stimulated channels. The spread of excitation by a single intraneural electrode is broader than that by an acoustic tone but narrower than that by a cochlear-implant electrode. In the present study, we compare in an animal model two sites of intraneural stimulation: the modiolar trunk of the nerve accessed using a transcochlear approach and the intracranial portion of the nerve accessed using a posterior fossa approach. The two stimulation sites offer very similar thresholds, spread of activation, and dynamic ranges. The intracranial site differed in that there was greater between-animal variation in tonotopic patterns. We discuss the implications of these results for possible improvements in hearing prosthesis for human subjects. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Middlebrooks, John C.] Univ Michigan, Dept Otolaryngol & Biomed Engn, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Snyder, Russell L.] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, Epstein Lab, San Francisco, CA 94143 USA.
[Snyder, Russell L.] Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
RP Middlebrooks, JC (reprint author), Univ Michigan, Dept Otolaryngol & Biomed Engn, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM jmidd@umich.edu; rsnyder@ohns.ucsf.edu
FU NIDCD [N01-DC-5-0005, P30-DC05188]
FX We thank Jim Wiler for his expert technical support and Zekiye Onsan for
help with the figures. Dr. Bryan Pfingst and Alana Kirby provided useful
comments on the manuscript. Supported by NIDCD N01-DC-5-0005 and
P30-DC05188.
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NR 40
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 52
EP 63
DI 10.1016/j.heares.2008.04.001
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000006
PM 18485635
ER
PT J
AU McCreery, DB
AF McCreery, D. B.
TI Cochlear nucleus auditory prostheses
SO HEARING RESEARCH
LA English
DT Article
DE cochlear nucleus; central auditory prostheses; humans; cats; electric
stimulation
ID BRAIN-STEM IMPLANT; DEGENERATION FOLLOWING LESIONS; SPIRAL GANGLION
PROJECTIONS; INFERIOR COLLICULUS; ACOUSTIC STRIAE; AMPLITUDE-MODULATION;
CORTICAL IMAGES; CHOPPER UNITS; OCTOPUS CELLS; NERVE FIBERS
AB Persons who lack an auditory nerve cannot benefit from cochlear implants, but a prosthesis utilizing an electrode array implanted on the surface of the cochlear nucleus can restore some hearing. Worldwide, more than 500 persons have received these "auditory brainstem implants," most commonly after removal of the tumors that occur with Type 2 Neurofibromatosis (NF2). Typically, the ABIs provide these individuals with improved speech perception when combined with lip-reading and useful perception of environmental sounds, but little open-set speech recognition. The feasibility of supplementing the array of surface electrodes with penetrating microstimulating electrodes has been investigated in animal studies, and 10 persons with NF2 have received implants that include a surface array and an array of penetrating microelectrodes. Their speech perception is not significantly better than that of the NF2 patients who have only the surface arrays, but the findings do validate the concept of intranuclear stimulation and suggest how such prostheses might be improved by modifying the microstimulating array and also by optimizing the sound processing strategies. Recent publications have described ABI patients with deafness of etiologies other than NF2 who have achieved open-set speech recognition. This suggests that the cochlear nuclei of the NF2 patients are damaged by the disease process or during surgical removal of the tumor. (C) 2007 Published by Elsevier B.V.
C1 Huntington Med Res Inst, Neural Engn Program, Pasadena, CA 91105 USA.
RP McCreery, DB (reprint author), Huntington Med Res Inst, Neural Engn Program, 734 Fairmount Ave, Pasadena, CA 91105 USA.
EM dougmc@hmri.org
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NR 83
TC 42
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 64
EP 73
DI 10.1016/j.heares.2007.11.014
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000007
PM 18207678
ER
PT J
AU Lim, HH
Lenarz, T
Anderson, DJ
Lenarz, M
AF Lim, Hubert H.
Lenarz, Thomas
Anderson, David J.
Lenarz, Minoo
TI The auditory midbrain implant: Effects of electrode location
SO HEARING RESEARCH
LA English
DT Article
DE auditory midbrain implant; auditory brainstem implant; central auditory
pathways; deep brain stimulation; functional zones; inferior colliculus
ID BRAIN-STEM IMPLANT; INFERIOR COLLICULUS; COCHLEAR IMPLANTS;
ELECTRICAL-STIMULATION; GUINEA-PIG; SPEECH RECOGNITION; CENTRAL NUCLEUS;
INTENSITY DISCRIMINATION; FUNCTIONAL-ORGANIZATION; MERIONES-UNGUICULATUS
AB The auditory midbrain implant (AMI) is a new hearing prosthesis designed for stimulation of the inferior colliculus in patients who do not receive sufficient benefit from cochlear or brainstem prostheses. We have begun clinical trials in which three patients have been implanted with the AMI Although the intended target was the central nucleus of the inferior colliculus (ICC), the electrode array was implanted into different locations across patients (i.e., ICC, dorsal cortex of inferior colliculus, lateral lemniscus). In this paper, we will summarize the effects of electrical stimulation of these different midbrain regions on various psychophysical properties and speech perception performance. The patient implanted within the intended target, the ICC, exhibited the greatest improvements in hearing performance. However, this patient has not yet achieved open-set speech perception to the performance level typically observed for cochlear implant patients, which we believe is partially due to the location of the array within the ICC. We will present findings from previous AMI studies in guinea pigs demonstrating the existence of spatially distinct functional output regions within the ICC and suggesting that further improvements in performance may be achieved by stimulating within a rostral-ventral region. Remaining questions include if a similar organization exists in the human ICC and if stimulation of its rostral-ventral region with currently available strategies (i.e., those designed for cochlear implants) can restore sufficient speech perception. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Lim, Hubert H.; Lenarz, Thomas; Lenarz, Minoo] Hannover Med Sch, Dept Otorhinolaryngol, D-30625 Hannover, Germany.
[Lim, Hubert H.; Anderson, David J.] Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Lim, HH (reprint author), HNO Klin, Med Hsch Hannover, Carl Neuberg Str 1,Gebaeude K5,Ebene 1,Raum 4010, D-30625 Hannover, Germany.
EM hubertlim@aol.com; lenarz.thomas@mh-hanno-ver.de; dja@umich.edu;
lenarz.minoo@mh-hannover.de
FU NIH [P41 EB2030, P30 DC05188, T32 DC00011, F31 DC007009]; German
Research Foundation [SFB 599]; Cochlear Ltd.; University of Michigan
FX Human studies: We would like to thank Rolf-Dieter Battmer, Gert Joseph,
Urte Rost, and Joerg Pesch for involvement with AMI patient testing and
fitting; Madjid Samii, Amir Samii, and the International Neuroscience
Institute (Hannover, Germany) for AMI surgery; and James F. Patrick,
Frank Risi, and Cochlear Ltd. (Lane Cove, Australia) for AMI development
and technical assistance. We also thank Hans-Joachim Kretschmann, Martin
Bokemeyer, and the Anatomy and Neuroradiology Departments at Hannover
Medical University for CT-MRI reconstructions and identification of the
AMI array location in each patient. Funding was provided by Cochlear
Ltd. Animal studies: We would like to thank James Wiler, Guenter Reuter,
Alexandru C. Stan, Uta Reich, Gerrit Paasche, Nadine Marquardt, Marc N.
Klingberg, and Anke Neuheiser for involvement with the electrophysiology
and chronic studies; and Jamille Hetke and the University of Michigan
Center for Neural Communication Technology (NIH P41 EB2030) for
multi-site stimulation and recording probes. Funding was provided by NIH
through P41 EB2030, P30 DC05188, T32 DC00011, and F31 DC007009; Cochlear
Ltd.; German Research Foundation (SFB 599); and the University of
Michigan Center for Wireless Integrated MicroSystems (NSF Engineering
Research Center).
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NR 63
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 74
EP 85
DI 10.1016/j.heares.2008.02.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000008
PM 18348902
ER
PT J
AU Altschuler, RA
O'Shea, KS
Miller, JM
AF Altschuler, Richard A.
O'Shea, K. Sue
Miller, Josef M.
TI Stem cell transplantation for auditory nerve replacement
SO HEARING RESEARCH
LA English
DT Article
DE spiral ganglion neurons; cochlea; auditory; deafness; embryonic stem
cells
ID NEONATALLY DEAFENED CATS; INTRACOCHLEAR ELECTRICAL-STIMULATION;
SENSORINEURAL HEARING-LOSS; NEURAL PROGENITOR CELLS; SPIRAL-GANGLION
NEURONS; MOUSE INNER-EAR; COCHLEAR-IMPLANT; GUINEA-PIG; NEUROTROPHIC
FACTORS; GROWTH-FACTOR
AB The successful function of cochlear prostheses depends on activation of auditory nerve. The survival of auditory nerve neurons, however, can vary widely in candidates for cochlear implants and influence implant efficacy. Stem cells offer the potential for improving the function of cochlear prostheses and increasing the candidate pool by replacing lost auditory nerve. The first phase of studies for stem cell replacement of auditory nerve has examined the in vitro survival and differentiation as well as in vivo differentiation and survival of exogenous embryonic and tissue stem cells placed into scala tympani and/or modiolus. These studies are reviewed and new results on in vivo placement of B-5 mouse embryonic stem cells into scala tympani of the guinea pig cochleae with differentiation into a glutamatergic neuronal phenotype are presented. Research on the integration and connections of stem cell derived neurons in the cochlea is described. Finally, an alternative approach is considered, based on the use of endogenous progenitors rather than exogenous stem cells, with a review of promising findings that have identified stem cell-like progenitors in cochlear and vestibular tissues to provide the potential for auditory nerve replacement. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Altschuler, Richard A.; Miller, Josef M.] Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Altschuler, Richard A.; O'Shea, K. Sue] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA.
RP Altschuler, RA (reprint author), Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, 1150W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM shuler@umich.edu
FU NIH [DC03820, GM069985 (KSO), NS04187 (KSO), P30 DC05188]; GM/UAW
FX We would like to thank Mat Velkey, Diane Prieskorn and Noel Wys for
their contributions to generating the new data described in this
manuscript. These studies were supported by NIH grants DC03820 (RAA,
JMM), GM069985 (KSO), NS04187 (KSO), P30 DC05188 and by GM/UAW funds.
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NR 57
TC 24
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 110
EP 116
DI 10.1016/j.heares.2008.06.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000011
PM 18585449
ER
PT J
AU Xu, L
Pfingst, BE
AF Xu, Li
Pfingst, Bryan E.
TI Spectral and temporal cues for speech recognition: Implications for
auditory prostheses
SO HEARING RESEARCH
LA English
DT Article
DE speech recognition; spectral cues; temporal cues; cochlear implants
ID MANDARIN TONE RECOGNITION; DESYNCHRONIZING PULSE TRAINS; COCHLEAR
IMPLANT RECIPIENTS; SENSORINEURAL HEARING-LOSS; CONSONANT RECOGNITION;
ELECTRICAL-STIMULATION; FUNDAMENTAL-FREQUENCY; VOWEL IDENTIFICATION;
PROSODIC PERCEPTION; PHONEME RECOGNITION
AB Features of stimulation important for speech recognition in people with normal hearing and in people using implanted auditory prostheses include spectral information represented by place of stimulation along the tonotopic axis and temporal information represented in low-frequency envelopes of the signal. The relative contributions of these features to speech recognition and their interactions have been studied using vocoder-like simulations of cochlear implant speech processors presented to listeners with normal hearing. In these studies, spectral/place information was manipulated by varying the number of channels and the temporal-envelope information was manipulated by varying the lowpass cutoffs of the envelope extractors. Consonant and vowel recognition in quiet reached plateau at 8 and 12 channels and lowpass cutoff frequencies of 16 Hz and 4 Hz, respectively. Phoneme (especially vowel) recognition in noise required larger numbers of channels. Lexical tone recognition required larger numbers of channels and higher lowpass cutoff frequencies. There was a tradeoff between spectral/place and temporal-envelope requirements. Most current auditory prostheses seem to deliver adequate temporal-envelope information, but the number of effective channels is suboptimal, particularly for speech recognition in noise. lexical tone recognition, and music perception. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Xu, Li] Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
[Xu, Li; Pfingst, Bryan E.] Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Xu, L (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
EM xul@ohio.edu
FU NIH [R01 DC03808, T32 DC00011, F32 DC00470, R03 DC006161, P30 DC05188]
FX We acknowledge the technical assistance from Cathy Thompson, Yuhjung
Tsai, and Yunfang Zheng. Ning Zhou provided valuable comments on an
earlier version of the manuscript. Supported by NIH Grants R01 DC03808,
T32 DC00011, F32 DC00470, R03 DC006161, P30 DC05188, and Ohio University
research awards.
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NR 81
TC 29
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 132
EP 140
DI 10.1016/j.heares.2007.12.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000013
PM 18249077
ER
PT J
AU van Wieringen, A
Macherey, O
Carlyon, RP
Deeks, JM
Wouters, J
AF van Wieringen, Astrid
Macherey, Olivier
Carlyon, Robert P.
Deeks, John M.
Wouters, Jan
TI Alternative pulse shapes in electrical hearing
SO HEARING RESEARCH
LA English
DT Article
DE auditory prosthesis; cochlear implant; asymmetric pulse shapes; pulse
polarity; spatial selectivity
ID COCHLEAR IMPLANT USERS; CENTRAL-NERVOUS-SYSTEM; AUDITORY-NERVE;
ACTION-POTENTIALS; MONOPHASIC STIMULATION; NEURAL STIMULATION;
INTERPHASE GAP; WAVE-FORM; MODEL; DURATION
AB Cochlear implants (CIs) stimulate the auditory nerve with trains of symmetric biphasic (BI) pulses. We review studies showing that more efficient stimulation can be achieved by modifying these pulses by (1) increasing the inter-phase gap (IPG) between the two phases of each pulse, thereby delaying the recovery of charge, (2) increasing the duration and decreasing the amplitude of one phase - so-called "pseudomonophasic (PS)" waveforms, and (3) combining the pseudomonophasic stimulus with an IPG in a "delayed pseudomonophasic" waveform (PS_IPG). These efficiency gains, measured using changes in threshold and loudness, occur at a wide range of pulse rates, including those commonly used in current Cl systems. In monopolar mode, dynamic ranges are larger for PS and for long-IPG pulse shapes than for BI pulses, but this increase in DR is not accompanied by a higher number of discriminable loudness steps, and hence, in a better coding of loudness. Moreover, waveforms with relatively short and long interphase gaps do not yield different patterns of excitation despite the relatively large differences in threshold. Two important findings are that, contrary to data obtained in animal experiments, anodic currents are more effective than cathodic stimulation for human CI patients and that the thresholds decrease with increases in IPG over a much longer time course (more than 3 ms) than for animals. In this review it is discussed how these alternative pulse shapes may be beneficial in terms of reducing power consumption and channel interactions, which issues remain to be addressed, and how models contribute to guiding our research. (C) 2008 Elsevier B.V. All rights reserved.
C1 [van Wieringen, Astrid; Macherey, Olivier; Wouters, Jan] Katholieke Univ Leuven, Dept Neurosci, ExpORL, B-3000 Louvain, Belgium.
[Macherey, Olivier; Carlyon, Robert P.; Deeks, John M.] MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England.
RP van Wieringen, A (reprint author), Katholieke Univ Leuven, Dept Neurosci, ExpORL, Herestr 49,Bus 721, B-3000 Louvain, Belgium.
EM astrid.vanwieringen@med.kuleuven.be
RI Carlyon, Robert/A-5387-2010; Wouters, Jan/D-1800-2015
FU Kath-olieke Universiteit Leuven [OT/99/33, OT/03/58]
FX This article was prepared while the first and second authors were
supported by a Grant from the Research Council of the Kath-olieke
Universiteit Leuven (OT/99/33, OT/03/58).
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VANWIERINGEN A, 2005, C IMPL AUD PROSTH JU
NR 52
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 154
EP 163
DI 10.1016/j.heares.2008.03.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000015
PM 18468821
ER
PT J
AU Turner, CW
Reiss, LAJ
Gantz, BJ
AF Turner, Christopher W.
Reiss, Lina A. J.
Gantz, Bruce J.
TI Combined acoustic and electric hearing: Preserving residual acoustic
hearing
SO HEARING RESEARCH
LA English
DT Article
DE acoustic plus electric (A plus E); cochlear implant; sensorineural
hearing loss
ID COCHLEAR IMPLANT LISTENERS; SPEECH RECOGNITION; IMPAIRED LISTENERS;
AUDITORY-SYSTEM; TEMPORAL CUES; LOW-FREQUENCY; STIMULATION; PERCEPTION;
NOISE; PRESERVATION
AB The topic of this review is the strategy of preserving residual acoustic hearing in the implanted ear to provide combined electrical stimulation and acoustic hearing as a rehabilitative strategy for sensorineural hearing loss. This chapter will concentrate on research done with the Iowa/Nucleus 10 mm Hybrid device, but we will also attempt to summarize strategies and results from other groups around the world who use slightly different approaches. A number of studies have shown that preserving residual acoustic hearing in the implanted ear is a realistic goal for many patients with severe high-frequency hearing loss. The addition of the electric stimulation to their existing acoustic hearing can provide increased speech recognition for these patients. In addition, the preserved acoustic hearing can offer considerable advantages, as compared to a traditional cochlear implant, for tasks such as speech recognition in backgrounds or appreciation of music and other situations where the poor frequency resolution of electric stimulation has been a disadvantage. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Turner, Christopher W.; Reiss, Lina A. J.] Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
[Turner, Christopher W.; Gantz, Bruce J.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
RP Turner, CW (reprint author), Univ Iowa, Dept Speech Pathol & Audiol, 121B SHC Bldg, Iowa City, IA 52242 USA.
EM christopher-turner@uiowa.edu
FU NIDCD [R01 DC000377, P50 DC00242]
FX This research was supported by Grants from the NIDCD (R01 DC000377, P50
DC00242).
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NR 53
TC 51
Z9 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 164
EP 171
DI 10.1016/j.heares.2007.11.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000016
PM 18164883
ER
PT J
AU Pfingst, BE
Burkholder-Juhasz, RA
Zwolan, TA
Xu, L
AF Pfingst, Bryan E.
Burkholder-Juhasz, Rose A.
Zwolan, Teresa A.
Xu, Li
TI Psychophysical assessment of stimulation sites in auditory prosthesis
electrode arrays
SO HEARING RESEARCH
LA English
DT Article
DE auditory prosthesis; cochlear implant; psychophysics; detection
threshold; electrode discrimination; modulation detection; channel
interaction; speech recognition
ID COCHLEAR IMPLANT USERS; MODULATION TRANSFER-FUNCTIONS; BRAIN-STEM
IMPLANT; SPEECH RECOGNITION; STIMULUS LEVEL; ELECTRICAL-STIMULATION;
INTENSITY DISCRIMINATION; NEURAL DEGENERATION; GAP DETECTION;
CONFIGURATION
AB Auditory prostheses use implanted electrode arrays that permit stimulation at many sites along the tonotopic axis of auditory neurons. Psychophysical studies demonstrate that measures of implant function, such as detection and discrimination thresholds, vary considerably across these sites, that the across-site patterns of these measures differ across subjects, and that the likely mechanisms underlying this variability differ across measures. Psychophysical and speech recognition studies suggest that not all stimulation sites contribute equally to perception with the prosthesis and that some sites might have negative effects on perception. Studies that reduce the number of active stimulation sites indicate that most cochlear implant users can effectively utilize a maximum of only about seven sites in their processors. These findings support a strategy for improving implant performance by selecting only the best stimulation sites for the processor map. Another approach is to revise stimulation parameters for ineffective sites in an effort to improve acuity at those sites. In this paper, we discuss data supporting these approaches and some potential pitfalls. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Pfingst, Bryan E.; Burkholder-Juhasz, Rose A.; Zwolan, Teresa A.; Xu, Li] Univ Michigan Hlth Syst, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
[Zwolan, Teresa A.] Univ Michigan Hlth Syst, Dept Otolaryngol, Hearing Rehabil Ctr, Ann Arbor, MI 48108 USA.
[Xu, Li] Ohio Univ, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
RP Pfingst, BE (reprint author), Univ Michigan Hlth Syst, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
EM bpfingst@umich.edu
FU NIH/NIDCD [R01 DC 03808, R01 DC 04312, T32 DC 00011, P30 DC05188]
FX We express appreciation to Cathy Thompson and Gina Su for technical
assistance and to the human subjects for their diligence and hard work
in these experiments. Research reported from our laboratories was
supported primarily by NIH/NIDCD Grants R01 DC 03808, R01 DC 04312, T32
DC 00011, and P30 DC05188.
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NR 77
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 172
EP 183
DI 10.1016/j.heares.2007.11.007
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000017
PM 18178350
ER
PT J
AU Miller, CA
Brown, CJ
Abbas, PJ
Chi, SL
AF Miller, Charles A.
Brown, Carolyn J.
Abbas, Paul J.
Chi, Siu-Ling
TI The clinical application of potentials evoked from the peripheral
auditory system
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; evoked potentials; electric stimulation; compound
action potential (CAP); auditory brainstem response (ABR)
ID COCHLEAR IMPLANT USERS; NERVE ACTION-POTENTIALS; BRAIN-STEM RESPONSE;
MULTICHANNEL ELECTRICAL-STIMULATION; SPIRAL GANGLION-CELLS; GUINEA-PIG;
PSYCHOPHYSICAL MEASURES; CHANNEL INTERACTION; NEURAL EXCITATION;
TEMPORAL INTEGRATION
AB The auditory nerve is the obligatory pathway between the cochlea and the central nervous system. As the fibers of the mammalian auditory nerve share with each other many response properties when stimulated electrically (Kiang, 1965). it is reasonable to assume that the summed, or gross, electrical response of a fiber ensemble can provide researchers with meaningful information about nerve function. This chapter describes the gross responses of the auditory nerve that can be evoked by stimuli delivered by one or more electrodes implanted within the cochlea. Two manifestations of this potential - the electrically evoked compound action potential (ECAP) and the electrically evoked auditory brainstem response (EABR) - are introduced and compared. Some implant devices include systems that allow ECAPs to be routinely recorded from electrodes within the cochlea in clinical settings. While such systems have increased the popularity of the ECAP, unique advantages of the EABR are noted. Both potentials have assisted the clinical management of implant recipients and increase our understanding of how the human auditory system responds to electrical stimulation. The goals of this chapter are to review response characteristics of the whole-nerve response, the extent to which they provide information about underlying auditory nerve fiber activity, and limitations to their interpretation. This report will focus on describing and reviewing data collected from various clinical studies and interpreting these results on the basis of theoretical considerations and pertinent results from animal studies. Future research directions, which will likely involve the integration of various dimensions of the electrically evoked response that have been studied in isolation, are also suggested. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Miller, Charles A.; Brown, Carolyn J.; Abbas, Paul J.; Chi, Siu-Ling] Univ Iowa, Dept Otolaryngol, Iowa City, IA 52242 USA.
[Brown, Carolyn J.; Abbas, Paul J.; Chi, Siu-Ling] Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
RP Miller, CA (reprint author), Univ Iowa, Dept Otolaryngol, Iowa City, IA 52242 USA.
EM charles-miller@uiowa.edu
FU United States National Institute on Deafness and Other Communication
Disorders [P50-DC00242, R01-DC006478]
FX Aspects of this work were supported by grants from the United States
National Institute on Deafness and Other Communication Disorders
(P50-DC00242 and R01-DC006478).
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NR 83
TC 31
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 184
EP 197
DI 10.1016/j.heares.2008.04.005
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000018
PM 18515023
ER
PT J
AU Fu, QJ
Galvin, JJ
AF Fu, Qian-Jie
Galvin, John J., II
TI Maximizing cochlear implant patients' performance with advanced speech
training procedures
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implants; targeted auditory training; auditory rehabilitation
ID SPECTRALLY SHIFTED SPEECH; NORMAL-HEARING LISTENERS; CONSONANT
RECOGNITION; PERCEPTUAL ADAPTATION; TEMPORAL RESOLUTION; PROCESSING
STRATEGY; ELECTRIC HEARING; CODING STRATEGY; USERS; NOISE
AB Advances in implant technology and speech processing have provided great benefit to many cochlear implant patients. However, some patients receive little benefit from the latest technology, even after many years' experience with the device. Moreover, even the best cochlear implant performers have great difficulty understanding speech in background noise, and music perception and appreciation remain major challenges. Recent studies have shown that targeted auditory training can significantly improve cochlear implant patients' speech recognition performance. Such benefits are not only observed in poorly performing patients, but also in good performers under difficult listening conditions (e.g., speech noise, telephone speech, music, etc.). Targeted auditory training has also been shown to enhance performance gains provided by new implant devices and/or speech processing strategies. These studies suggest that cochlear implantation alone may not fully meet the needs of many patients, and that additional auditory rehabilitation may be needed to maximize the benefits of the implant device. Continuing research will aid in the development of efficient and effective training protocols and materials, thereby minimizing the costs (in terms of time, effort and resources) associated with auditory rehabilitation while maximizing the benefits of cochlear implantation for all recipients. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Fu, Qian-Jie; Galvin, John J., II] House Ear Res Inst, Dept Auditory Implants & Percept, Los Angeles, CA 90057 USA.
RP Fu, QJ (reprint author), House Ear Res Inst, Dept Auditory Implants & Percept, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM qfu@hei.org
FU NIDCD [R01DC004792]
FX Research was partially supported by NIDCD Grant R01DC004792.
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NR 76
TC 41
Z9 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2008
VL 242
IS 1-2
BP 198
EP 208
DI 10.1016/j.heares.2007.11.010
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 345TG
UT WOS:000259019000019
PM 18295992
ER
PT J
AU Markaryan, A
Nelson, EG
Tretiakova, M
Hinojosa, R
AF Markaryan, Adam
Nelson, Erik G.
Tretiakova, Maria
Hinojosa, Raul
TI Technical report: Immunofluorescence and TUNEL staining of celloidin
embedded human temporal bone tissues
SO HEARING RESEARCH
LA English
DT Article
DE human temporal bones; immunofluorescence staining; TUNEL staining
ID INNER-EAR; IMMUNOHISTOCHEMISTRY; SECTIONS; PRESBYCUSIS; MEMBRANE; DNA
AB The large archival human temporal bone collections of the world have been fixed in formalin and embedded in celloidin. These treatments have created challenges to the use of contemporary probes, which are routinely used in the evaluation of fresh and frozen tissues, for the analysis of archival temporal bone tissues. Formalin alters the configuration of proteins and can obscure antigens by modifying the epitopes recognized by antibodies. Celloidin embedding provides superior support of the delicate membranous structures of the inner ear to maintain tissue integrity during sectioning, however, inadequate removal of celloidin may limit tissue permeability resulting in poor penetration of large molecules. Methods are described in this manuscript that have allowed reproducible immunofluorescence and TUNEL (terminal deoxynucleotidyl transferase mediated dUTP nick end labeling) staining results in these archival tissues. To our knowledge, successful immunofluorescence staining of type I collagen, immunofluorescence staining of cytochrome c oxidase subunit III (COX 111), and TUNEL staining in archival human temporal bone tissues with confocal microscopy has not been previously reported. These results demonstrate the utility of developing techniques to evaluate the existing collections of archival temporal bones which remain our greatest source of tissue for investigating the causes of ear diseases. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Markaryan, Adam; Nelson, Erik G.; Hinojosa, Raul] Univ Chicago, Dept Surg, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA.
[Tretiakova, Maria] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA.
RP Markaryan, A (reprint author), Univ Chicago, Dept Surg, Sect Otolaryngol Head & Neck Surg, 5841 S Maryland Ave,MC 1035, Chicago, IL 60637 USA.
EM amarkary@surgery.bsd.uchicago.edu
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NR 19
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 1
EP 6
DI 10.1016/j.heares.2008.04.009
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200001
PM 18547759
ER
PT J
AU Farahbakhsh, NA
Narins, PM
AF Farahbakhsh, Nasser A.
Narins, Peter M.
TI Slow motility in hair cells of the frog amphibian papilla: Myosin light
chain-mediated shape change
SO HEARING RESEARCH
LA English
DT Article
DE auditory hair cells; kinase/phosphatase dependence; iso-volumetric
shortening
ID DEPENDENT PROTEIN-KINASES; SMOOTH-MUSCLE MYOSIN; GUINEA-PIG COCHLEA;
INTRACELLULAR CALCIUM; SOMATIC MOTILITY; PHOSPHORYLATION;
ELECTROMOTILITY; ACETYLCHOLINE; INHIBITORS; CALMODULIN
AB Using video, fluorescence and confocal microscopy, quantitative analysis and modeling, we investigated intracellular processes mediating the calcium/calmodulin (Ca2+/CaM)-dependent slow motility in hair cells dissociated from the rostral region of amphibian papilla, one of the two auditory organs in frogs. The time course of shape changes in these hair cells during the period of pretreatment with several specific inhibitors, as well as their response to the calcium ionophore, ionomycin, were recorded and compared. These cells respond to ionomycin with a tri-phasic shape change: an initial phase of iso-volumetric length decrease; a period of concurrent shortening and swelling; and the final phase of increase in both length and volume. We found that both the myosin light chain kinase inhibitor, ML-7, and antagonists of the multifunctional Ca2+/CaM-dependent kinases, KN-62 and KN-93, inhibit the iso-volumetric shortening phase of the response to ionomycin. The type 1 protein phosphatase inhibitors, calyculin A and okadaic acid induce minor shortening on their own, but do not significantly alter phase I response. However, they appear to counter effects of the inhibitors of Ca2+/CaM-dependent kinases. We hypothesize that an active actomyosin-based process mediates the iso-volumetric shortening in the frog rostral amphibian papillar hair cells. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Farahbakhsh, Nasser A.; Narins, Peter M.] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
[Narins, Peter M.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA.
RP Farahbakhsh, NA (reprint author), Univ Calif Los Angeles, Dept Physiol Sci, 621 Charles E Yong Dr S, Los Angeles, CA 90095 USA.
EM farahbak@ucla.edu
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NR 56
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 7
EP 17
DI 10.1016/j.heares.2008.04.007
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200002
PM 18534795
ER
PT J
AU Tan, MN
Robertson, D
Hammond, GR
AF Tan, Michael N.
Robertson, Donald
Hammond, Geoffrey R.
TI Separate contributions of enhanced and suppressed sensitivity to the
auditory attentional filter
SO HEARING RESEARCH
LA English
DT Article
DE auditory; attention; olivocochlear; cuing; detection; antimasking
ID ACTIVE MICROMECHANICAL PROPERTIES; SINGLE OLIVOCOCHLEAR NEURONS;
PROBE-SIGNAL METHOD; UNCERTAIN-FREQUENCY; VISUAL-ATTENTION; GUINEA-PIG;
EVOKED-POTENTIALS; NERVE RESPONSE; MASKED TONES; NOISE
AB Three experiments used a probe-signal method to determine the extent to which exposure-related changes in sensitivity result from an immediate effect of stimulation and from a cumulative effect of repeated stimulation. In the first experiment, a fixed-frequency cue was followed by a same-frequency target (on 75% of trials) or a different-frequency probe (on 25% of trials). In the second experiment, a cue frequency selected randomly from a set of five was followed by a same-frequency target, or one of four different-frequency probes. Targets and probes were randomly selected independently of the cue frequency and all were equiprobable (20%). Target detection showed an average 3.4 dB advantage over probe detection. In the third experiment, tones with a randomly selected frequency were detected better when cued by a tone of the same-frequency than when presented without a prior cue. The cued tones showed an average 2.6 dB advantage over the uncued tones. Together, these results suggest that two mechanisms contribute to changes in sensitivity following auditory stimulation: first, an immediate enhancement of target detection produced by an auditory cue and second, a suppression of non-target frequencies caused by the expectation of a target. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Tan, Michael N.; Robertson, Donald] Univ Western Australia, Auditory Lab, Sch Biomed Biomol & Chem Sci, Nedlands, WA 6009, Australia.
[Hammond, Geoffrey R.] Univ Western Australia, Sch Psychol, Nedlands, WA 6009, Australia.
RP Tan, MN (reprint author), Univ Western Australia, Auditory Lab, Sch Biomed Biomol & Chem Sci, Nedlands, WA 6009, Australia.
EM tanm01@tartarus.uwa.edu.au
RI Hammond, Geoff/H-9343-2014
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NR 43
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 18
EP 25
DI 10.1016/j.heares.2008.04.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200003
PM 18524512
ER
PT J
AU Bielefeld, EC
Coling, D
Chen, GD
Li, M
Tanaka, C
Hu, BH
Henderson, D
AF Bielefeld, Eric C.
Coling, Donald
Chen, Guang-Di
Li, Manna
Tanaka, Chiemi
Hu, Bo-Hua
Henderson, Donald
TI Age-related hearing loss in the Fischer 344/NHsd rat substrain
SO HEARING RESEARCH
LA English
DT Article
DE presbycusis; Fischer 344 rat; endocochlear potential; compound action
potential
ID STRIA VASCULARIS; LATERAL WALL; COCHLEAR; DEGENERATION; PRESBYCUSIS;
POTENTIALS; MICE; NA,K-ATPASE; PATHOLOGY; GENOTYPES
AB Studies of the F344 rat have shown a variety of age-related auditory anatomy and physiology changes. The current study was undertaken to clarify the ARHL in the F344 rat, by examining the auditory pathway of the F344/NHsd substrain that is distributed by Harlan Laboratories for research in the United States. The F344/NHsd rat begins to lose its hearing at about 12 months, and by 24 months, there are 50-60 dB auditory brainstem response threshold shifts at 20 and 40 kHz and 20 dB losses at 5-10 kHz. Distortion product otoacoustic emissions (DPOAE) amplitudes at 1.8-12 kHz stimuli were depressed in the older (18-24 months) rats. Amplitude input-output functions of the compound action potential (CAP) were also depressed across frequency. The endocochlear potential (EP) was 90-100mV in the 3 month old rats. All but one of the 24 month old rats' EPs were in the +75-85 mV range. Tympanometry revealed no differences in middle ear function between the young and older rats. Collectively, these findings suggest damage to the outer hair cells, but anatomical examination of the outer hair cells revealed a relative lack of cell loss compared to the magnitude of the hearing and DPOAE loss. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Bielefeld, Eric C.; Coling, Donald; Chen, Guang-Di; Li, Manna; Tanaka, Chiemi; Hu, Bo-Hua; Henderson, Donald] SUNY Buffalo, Ctr Hearing & Deafness, Dept Commun Disorders & Sci, Buffalo, NY 14214 USA.
RP Bielefeld, EC (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, Dept Commun Disorders & Sci, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM ecb2@buffalo.edu
RI Bielefeld, Eric/D-2015-2012
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NR 33
TC 28
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 26
EP 33
DI 10.1016/j.heares.2008.04.006
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200004
PM 18508213
ER
PT J
AU Musacchia, G
Strait, D
Kraus, N
AF Musacchia, Gabriella
Strait, Dana
Kraus, Nina
TI Relationships between behavior, brainstem and cortical encoding of seen
and heard speech in musicians and non-musicians
SO HEARING RESEARCH
LA English
DT Article
DE language; music; multisensory; auditory; visual; ABR; FFR; plasticity
ID FREQUENCY-FOLLOWING RESPONSE; CORTICOFUGAL MODULATION; AUDITORY-SYSTEM;
INFERIOR COLLICULUS; SELECTIVE ATTENTION; LANGUAGE; PITCH; NONMUSICIANS;
PLASTICITY; CONNECTIONS
AB Musicians have a variety of perceptual and cortical specializations compared to non-musicians. Recent studies have shown that potentials evoked from primarily brainstem structures are enhanced in musicians, compared to non-musicians. Specifically, musicians have more robust representations of pitch periodicity and faster neural timing to sound onset when listening to sounds or both listening to and viewing a speaker. However, it is not known whether musician-related enhancements at the subcortical level are correlated with specializations in the cortex. Does musical training shape the auditory system in a coordinated manner or in disparate ways at cortical and subcortical levels? To answer this question, we recorded simultaneous brainstem and cortical evoked responses in musician and non-musician subjects. Brainstem response periodicity was related to early cortical response timing across all subjects, and this relationship was stronger in musicians. Peaks of the brainstem response evoked by sound onset and timbre cues were also related to cortical timing. Neurophysiological measures at both levels correlated with musical skill scores across all subjects. In addition, brainstem and cortical measures correlated with the age musicians began their training and the years of musical practice. Taken together, these data imply that neural representations of pitch, timing and timbre cues and cortical response timing are shaped in a coordinated manner, and indicate corticofugal modulation of subcortical afferent circuitry. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Musacchia, Gabriella; Strait, Dana; Kraus, Nina] Northwestern Univ, Auditory Neurosci Lab, Dept Commun Sci, Evanston, IL 60208 USA.
[Strait, Dana] Northwestern Univ, Sch Mus, Evanston, IL 60208 USA.
[Kraus, Nina] Northwestern Univ, Dept Neurobiol, Evanston, IL 60208 USA.
[Kraus, Nina] Northwestern Univ, Dept Physiol & Otolaryngol, Evanston, IL 60208 USA.
RP Musacchia, G (reprint author), Northwestern Univ, Auditory Neurosci Lab, Dept Commun Sci, 2240 Campus Dr, Evanston, IL 60208 USA.
EM g-musacchia@northwestern.edu
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TC 70
Z9 74
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 34
EP 42
DI 10.1016/j.heares.2008.04.013
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200005
PM 18562137
ER
PT J
AU Bibikov, NG
Chen, QC
Wu, FJ
AF Bibikov, N. G.
Chen, Q. C.
Wu, F. J.
TI Responses of inferior colliculus neurons to sounds presented at
different rates in anesthetized albino mouse
SO HEARING RESEARCH
LA English
DT Article
DE inferior colliculus; auditory units; duration tuning; stimulus
repetition rate; mouse
ID BIG BROWN BAT; DURATION TUNING CHARACTERISTICS; CAT AUDITORY-CORTEX;
EPTESICUS-FUSCUS; GABAERGIC INHIBITION; REPETITION RATE; HOUSE MOUSE;
SELECTIVITY; THRESHOLD; STIMULI
AB We recorded extracellular activity from 402 single units located in the inferior colliculus (IC) of barbiturate-anesthetized albino mice. The stimuli were pure tones at characteristic frequency (CF) with durations of 10, 40 and 100 ms and intensities ranged from 5 to 25 dB above unit's minimum threshold (MT). The tones were presented with different repetition rates (RRs) ranging from 0.2 to 20.0 Hz. At low intensities (5 dB above MT, determined at RR of 0.5 Hz) the great majority of units exhibited a strong decline of their responses when the stimulus RR was increased. About one-half of the units did not respond to 40 ms tones when they were stimulated with the RR of 3.0 Hz. This effect was even more pronounced for 100 ms tones. Generally, the increase in stimulus intensity led to an increase in the high-frequency border of RR. Nevertheless, even at intensities of 20-30 dB above MT, some units showed no response when the RR exceeded 5.0 Hz. In many cases the band-pass or high-pass duration tuning of the single unit was transformed to low-pass or all-pass when the rate was low enough to guarantee the independence of successive presentations of the stimuli. Responses of a very small group of IC units, however, were enhanced when the RR was increased. Our data have shown that the changes in the RR radically modify many features of the neural response (number of spikes, latency, discharge pattern, duration selectivity). We suggest that long-lasting inhibitory processes may be induced by low intensity stimuli in many units of the IC. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Bibikov, N. G.; Chen, Q. C.; Wu, F. J.] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
[Bibikov, N. G.] NN Andreyev Acoust Inst, Moscow 117036, Russia.
RP Wu, FJ (reprint author), Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
EM wufj@mail.ccnu.edu.cn
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NR 59
TC 2
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 43
EP 51
DI 10.1016/j.heares.2008.04.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200006
PM 18539419
ER
PT J
AU Kulesza, RJ
AF Kulesza, Randy J., Jr.
TI Cytoarchitecture of the human superior olivary complex: Nuclei of the
trapezoid body and posterior tier
SO HEARING RESEARCH
LA English
DT Article
DE auditory; hearing; brainstem; periolivary
ID CALCIUM-BINDING PROTEINS; AUDITORY BRAIN-STEM; SONG CONTROL-SYSTEM;
INFERIOR COLLICULUS; PARAOLIVARY NUCLEUS; PERIOLIVARY CELLS; COCHLEAR
NUCLEUS; MEDIAL NUCLEUS; FINE-STRUCTURE; GUINEA-PIGS
AB The superior olivary complex (SOC) is a cluster of nuclei situated in the caudal brainstem tegmentum that forms an essential component of the auditory pathway. The SOC includes two principal nuclei, the medial and lateral superior olives (MSO and LSO respectively), that have clear roles in sound source localization. Surrounding the principal nuclei are a number of periolivary nuclei (PON) that vary significantly between mammalian species but function in multiple aspects of hearing. Although the PON have been studied in numerous laboratory animals, these nuclei have not been delineated in human. The major goal of this study is to, based on myeloarchitecture, location, neuronal morphology and cytoarchitecture, define the PON within the human SOC and provide estimates of neuronal number within these nuclei. Results from the study of twelve human brainstems provide evidence for six morphologically distinct cell groups: three within the trapezoid body and three along the posterior aspect of the SOC. Based on the analysis of human tissue stained for myelin, Nissl substance, or impregnated with silver, the human PON appear largely homologous to the PON described in other low-frequency hearing animals. (C) 2008 Elsevier B.V. All rights reserved.
C1 Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
RP Kulesza, RJ (reprint author), Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
EM rkulesza@lecom.edu
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NR 60
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 52
EP 63
DI 10.1016/j.heares.2008.04.010
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200007
PM 18547760
ER
PT J
AU Su, GL
Colesa, DJ
Pfingst, BE
AF Su, Gina L.
Colesa, Deborah J.
Pfingst, Bryan E.
TI Effects of deafening and cochlear implantation procedures on
postimplantation psychophysical electrical detection thresholds
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; electrical detection threshold; neomycin deafening;
animal psychophysics; impedance; guinea pig
ID GUINEA-PIG; STIMULATION; PERFUSION; SURVIVAL; NEOMYCIN; TIME
AB Previous studies have shown large decreases in cochlear implant psychophysical detection thresholds during the weeks following the onset of electrical testing. The current study sought to determine the variables underlying these threshold decreases by examining the effects of four deafening and implantation procedures on detection thresholds and implant impedances. Thirty-two guinea pigs were divided into four matched groups. Group I was deafened and implanted Day 0 and began electrical testing Day 1. Group 11 was deafened and implanted Day 0 and began electrical testing Day 45. Group III was deafened Day 0, implanted Day 45 and began electrical testing Day 46. Group IV was not predeafened but was implanted Day 0 and began electrical testing Day 1. All groups showed threshold decreases over time but the magnitude of change, time course and final stable threshold levels depended on the type and time course of treatment. Impedances increased over the first two weeks following the onset of electrical testing except in Group II. Results suggest that multiple mechanisms underlie the observed threshold shifts including (1) recovery of the cochlea from a temporary pathology caused by the deafening and/or implantation procedures, (2) effects of electrical stimulation on the auditory pathway, and (3) tissue growth in the implanted cochlea. They also suggest that surviving hair cells influence electrical threshold levels. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Su, Gina L.; Colesa, Deborah J.; Pfingst, Bryan E.] Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
RP Pfingst, BE (reprint author), Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM bpfingst@umich.edu
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NR 22
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 64
EP 72
DI 10.1016/j.heares.2008.04.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200008
PM 18558467
ER
PT J
AU Bingabr, M
Espinoza-Varas, B
Loizou, PC
AF Bingabr, Mohamed
Espinoza-Varas, Blas
Loizou, Philipos C.
TI Simulating the effect of spread of excitation in cochlear implants
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; monopolar; bipolar; current spread; vocoder
ID SPEECH RECOGNITION; ELECTRODE CONFIGURATION; CURRENT DISTRIBUTIONS;
ELECTRICAL-FIELD; AUDITORY-NERVE; STIMULATION; HEARING; NUMBER;
PERFORMANCE; LISTENERS
AB A model was developed to simulate acoustically the effects of excitation spread in cochlear implants (CI). Based on neurophysiologic data, the proposed model simulates the electrical-current decay rate associated with broad and narrow types of excitation, such as those produced by monopolar and bipolar electrode configurations. The effect of excitation spread on speech intelligibility was simulated in normal-hearing subjects by varying the slopes of the synthesis bands in the noise vocoder. Sentences and monosyllabic words processed via 4-16 channels of stimulation with varying degrees of excitation spread were presented to normal-hearing listeners for identification. Results showed significant interaction between spectral resolution (number of channels) and spread of excitation. The effect of narrowing the excitation spread was minimal when the spectral resolution was sufficiently good (>8 channels) but it was significant when the spectral resolution was poor (4 channels). A significant decrement in performance was observed for extremely narrow excitation spread. This outcome is partly consistent with behavioral data obtained with cochlear implant studies in that Cl users tend to do as well or better with monopolar stimulation than with bipolar stimulation. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Bingabr, Mohamed] Univ Cent Oklahoma, Dept Engn & Phys, Edmond, OK 73034 USA.
[Espinoza-Varas, Blas] Univ Oklahoma, Hlth Sci Ctr, Dept Commun Sci & Disorders, Oklahoma City, OK 73104 USA.
[Loizou, Philipos C.] Univ Texas Dallas, Dept Elect Engn, Richardson, TX 75083 USA.
RP Bingabr, M (reprint author), Univ Cent Oklahoma, Dept Engn & Phys, 100 N Univ Dr, Edmond, OK 73034 USA.
EM mbingabr@ucok.edu; Blas-Espinoza-varas@ouhsc.edu; loizou@utdallas.edu
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NR 27
TC 25
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 73
EP 79
DI 10.1016/j.heares.2008.04.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200009
PM 18556160
ER
PT J
AU Heffner, RS
Koay, G
Heffner, HE
AF Heffner, R. S.
Koay, G.
Heffner, H. E.
TI Sound localization acuity and its relation to vision in large and small
fruit-eating bats: II. Non-echolocating species, Eidolon helvum and
Cynopterus brachyotis
SO HEARING RESEARCH
LA English
DT Article
DE localization acuity; megachiroptera; pteropodidae; yinpterochiroptera;
echolocation; vision; evolution
ID VISUAL-ACUITY; ROUSETTUS-AEGYPTIACUS; GANGLION-CELLS; BINAURAL CUES;
HEARING; SENSITIVITY; EVOLUTION; MAMMALS; CAT
AB Passive sound-localization acuity for 100-msec noise bursts was determined behaviorally for two species of non-echolocating bats: the Straw-colored fruit bat, Eidolon helvum, a large frugivore, and the Dog-faced fruit bat, Cynopterus brachyotis, a small frugivore. The mean minimum audible angle for two E. helvum was 11.7 degrees, and for two C brachyotis was 10.5 degrees. This places their passive sound-localization acuity near the middle of the range for echolocating bats as well as the middle of the range for other mammals. Sound-localization acuity varies widely among mammals, and the best predictor of this auditory function remains the width of the field of best vision (r = .89, p < .0001). Among echolocating and non-echolocating bats, as well as among other mammals, the use of hearing to direct the eyes to the source of a sound still appears to serve as an important selective factor for sound localization. Absolute visual acuity and the magnitude of the binaural locus cues available to a species remain unreliable predictors of sound-localization acuity. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Heffner, R. S.; Koay, G.; Heffner, H. E.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
RP Heffner, RS (reprint author), Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
EM Rickye.Heffner@utoledo.edu
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NR 40
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 80
EP 86
DI 10.1016/j.heares.2008.05.001
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200010
PM 18571883
ER
PT J
AU Loebach, JL
Wickesberg, RE
AF Loebach, Jeremy L.
Wickesberg, Robert E.
TI The psychoacoustics of noise vocoded speech: A physiological means to a
perceptual end
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; noise vocoded speech; spectrally reduced speech; speech
perception
ID NORMAL-HEARING LISTENERS; AUDITORY-NERVE FIBERS; COCHLEAR IMPLANT USERS;
DISCHARGE RATE REPRESENTATION; EVENT-RELATED POTENTIALS; STEADY-STATE
VOWELS; VOICE-ONSET TIME; CONSONANT RECOGNITION; ENVIRONMENTAL SOUNDS;
TEMPORAL CUES
AB Noise vocoded speech tokens produce temporal patterns in the ensemble response of the auditory nerve similar to those of their naturally produced counterparts [Loebach, J.L., Wickesberg, R.E., 2006. The representation of noise vocoded speech in the auditory nerve of the chinchilla: Physiological correlates for the perception of spectrally reduced speech. Hear. Res. 213 (1-2), 130-144]. Moreover, the degree of pattern similarity increased as more noise bands were used to synthesize the vocoded stimuli, suggesting a relationship between the patterns that these stimuli evoke in the auditory nerve and their recognition by human subjects. In order to make a direct comparison between the psychoacoustic and physiological domains, the present study obtained the perceptual identification scores for these stimuli. A set of 120 stimuli containing the 16 tokens of interest was presented to 30 young normal hearing subjects, who identified the tokens in a closed set task. Overall, the perceptual identification of the tokens increased in accuracy with the addition of noise bands. The neural pattern similarity was quantified using dynamic time warping, and correlated with the perceptual identification scores for the target stimuli of interest. A significant linear relationship between the pattern similarity and perceptual identification scores was found, such that as neural pattern similarity increased, the accuracy of stimulus identification also increased. These findings suggest a possible physiological substrate for the recognition of noise vocoded consonants. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Loebach, Jeremy L.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
[Loebach, Jeremy L.; Wickesberg, Robert E.] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA.
RP Loebach, JL (reprint author), Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
EM jeremyloebach@gmail.com; wickesbe@uiuc.edu
RI Imhof, Margarete/F-8471-2011
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NR 58
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 87
EP 96
DI 10.1016/j.heares.2008.05.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200011
PM 18556159
ER
PT J
AU Ishigami, Y
Phillips, DP
AF Ishigami, Yoko
Phillips, Dennis P.
TI Effect of stimulus hemifield on free-field auditory saltation
SO HEARING RESEARCH
LA English
DT Article
DE auditory saltation; spatial misperception; perceptual processing times;
clicks; inter-click interval
ID CUTANEOUS RABBIT; SOUND LOCATION; ILLUSION; LOCALIZATION; PERCEPTION;
TIME; CAT
AB Auditory saltation is the orderly misperception of the spatial location of repetitive click stimuli emitted from two successive locations when the inter-click intervals (ICIs) are sufficiently short. The clicks are perceived as originating not only from the actual source locations, but also from locations between them. In two tasks, the present experiment compared free-field auditory saltation for 90 degrees excursions centered in the frontal, rear, left and right acoustic hemifields, by measuring the ICI at which subjects report 50% illusion strength (subjective task) and the ICI at which subjects could not distinguish real motion from saltation (objective task). A comparison of the saltation illusion for excursions spanning the midline (i.e. for frontal or rear hemifields) with that for stimuli in the lateral hemifields (left or right) revealed that the illusion was weaker for the midline-straddling conditions (i.e. the illusion was restricted to shorter ICIs). This may reflect the contribution of two perceptual channels to the task in the midline conditions (as opposed to one in the lateral hemifield conditions), or the fact that the temporal dynamics of localization differ between the midline and lateral hemifield conditions. A subsidiary comparison of saltation supported in the left and right auditory hemifields, and therefore by the right and left auditory forebrains, revealed no difference. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Ishigami, Yoko; Phillips, Dennis P.] Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4J1, Canada.
RP Phillips, DP (reprint author), Dalhousie Univ, Dept Psychol, 1355 Oxford St, Halifax, NS B3H 4J1, Canada.
EM dennis.phillips@dal.ca
RI Phillips, Dennis/A-6496-2011
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NR 29
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2008
VL 241
IS 1-2
BP 97
EP 102
DI 10.1016/j.heares.2008.05.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 330ZK
UT WOS:000257981200012
PM 18565705
ER
PT J
AU Kaiser, CL
Chapman, BJ
Guidi, JL
Terry, CE
Mangiardi, DA
Cotanche, DA
AF Kaiser, Christina L.
Chapman, Brittany J.
Guidi, Jessica L.
Terry, Caitlin E.
Mangiardi, Dominic A.
Cotanche, Douglas A.
TI Comparison of activated caspase detection methods in the
gentamicin-treated chick cochlea
SO HEARING RESEARCH
LA English
DT Article
DE apoptosis; caspase; avian; aminoglycoside; cochlea; gentamicin; hair
cells
ID HAIR CELL-DEATH; VESTIBULAR SENSORY EPITHELIA; INNER-EAR; IN-VITRO; 2
MODES; APOPTOSIS; REGENERATION; PROGRESSION; NOISE; EXPRESSION
AB Aminoglycoside antibiotics induce caspase-dependent apoptotic death in cochlear hair cells. Apoptosis, a regulated form of cell death, can be induced by many stressors, which activate signaling pathways that result in the controlled dismantling of the affected cell. The caspase family of proteases is activated in the apoptotic signaling pathway and is responsible for cellular destruction. The intiator caspase-9 and the effector caspase-3 are both activated in chick cochlear hair cells following aminoglycoside exposure. We have analyzed caspase activation in the avian cochlea during gentamicin-induced hair cell death of compare two different methods of caspase detection: caspase antibodies and CaspaTag kits. Caspase anti-bodies bind to the cleaved activated form of caspase-9 or caspase-3 in specific locations in fixed tissue. CaspaTag is fluorescent inhibitor that binds to a reactive cysteine residue on the large subunit of the caspase heterodimer in in fixed tissue.
To induce cochlear hair cell loss, 1-2 week-old chickens received a single injection of gentamicin (300 mg/kg.) Chicks were caspase-9 or caspase-3 using either caspase-directed anitbodies or CapaTag kits. Ears were co-labeled with either phalloidin or myosin VI to visualize hair cells and to determine the progression of cochlear damage. The timing of caspase activation was similar for both assays; how-ever, caspase-9 and caspase-3 antibodies labeled only those cells currently undergoing apoptotic cells death. Conversely, CaspaTag-labeled all the cells that have undergone apoptotic cell death and ejection from the sensory epithelium, in addition to those that are currently in the cell death process. This makes CaspaTag ideal for showing an overall pattern or level of cell death over a period of time, while caspase antibodies provide a snapshot of cell death at a specific time point. (C) 2008 Elesvier B.V. All rights reserved.
C1 [Kaiser, Christina L.; Chapman, Brittany J.; Guidi, Jessica L.; Terry, Caitlin E.; Mangiardi, Dominic A.; Cotanche, Douglas A.] Boston Univ, Med Ctr, Dept Otolaryngol, Lab Cellular & Mol Hearing Res, Boston, MA 02118 USA.
[Kaiser, Christina L.; Cotanche, Douglas A.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA.
[Mangiardi, Dominic A.] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
RP Kaiser, CL (reprint author), Boston Univ, Med Ctr, Dept Otolaryngol, Lab Cellular & Mol Hearing Res, Evans 637,715 Albany St, Boston, MA 02118 USA.
EM ckaiser@bu.edu
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NR 32
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 1
EP 11
DI 10.1016/j.heares.2008.03.0003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500001
PM 18487027
ER
PT J
AU Faucher, K
Aas-Hansen, O
Damsgard, B
Stenklev, NC
AF Faucher, K.
Aas-Hansen, O.
Damsgard, B.
Stenklev, N. C.
TI Effects of systemic versus local gentamicin on the inner ear in the
Atlantic cod, Gadus morhua (L.), relevance for fish hearing
investigations
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; hair cells; Atlantic cod Gadus morhua (L.); gentamicin;
intrasaccular injection; intravenous injection
ID LATERAL LINE ORGAN; HAIR-CELLS; AMINOGLYCOSIDE ANTIBIOTICS; DIRECTIONAL
HEARING; DAMAGE; OTOTOXICITY; NEUROMASTS; EXPOSURE; RECOVERY; FIELD
AB Fish models are increasingly being used for hearing research investigations. Aminoglycoside antibiotics that are used for damaging the inner ear hair cells can have systemic side effects leading to death of study animals. This study aimed to compare two methods: (i) systemic (intravenous) and (ii) local (intrasaccular) gentamicin administration for induction of inner ear hair cell damage in the Atlantic cod, Gadus morhua (L.). Hair cell damage was assessed using scanning electron microscopy; hair cell density, prevalence of immature hair cells and kinocilia length were measured. Gentamicin-treated fish were compared with control and sham fish. Intravenous gentamicin led to dose-dependent mortality caused by nephrotoxicity. The only visible effect after treatment was more immature hair cells and shorter kinocilia, the effect on hair cell density was equivocal. Following intrasaccular gentamicin treatment, fish mortality was negligible, and hair cells were damaged regardless of dose. Here, we observed decreased hair cell density, high prevalence of immature hair cells, and significantly shortened kinocilia. Conclusion: intrasaccular injection is preferable to intravenous injection of gentamicin for the study of ototoxicity in the Atlantic cod. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Faucher, K.; Stenklev, N. C.] Univ Tromso, Inst Clin Med, ENT Dept, Tromso, Norway.
[Aas-Hansen, O.; Damsgard, B.] Norwegian Inst Fisheries & Aquaculture Res, N-9291 Tromso, Norway.
RP Faucher, K (reprint author), Univ Tromso, Inst Clin Med, ENT Dept, Tromso, Norway.
EM kfaucher@hotmail.fr
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NR 30
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 12
EP 21
DI 10.1016/j.heares.2008.03.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500002
PM 18485636
ER
PT J
AU Harrington, IA
Stecker, GC
Macpherson, EA
Middlebrooks, JC
AF Harrington, Ian A.
Stecker, G. Christopher
Macpherson, Ewan A.
Middlebrooks, John C.
TI Spatial sensitivity of neurons in the anterior, posterior, and primary
fields of cat auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE sound localization; auditory cortex
ID SOUND-SOURCE LOCATION; CORTICAL-NEURONS; SINGLE NEURONS; SUPERIOR
COLLICULUS; RECEPTIVE-FIELDS; COOLING DEACTIVATION; REPRESENTATION;
LOCALIZATION; ORGANIZATION; RESPONSES
AB We assessed the spatial-tuning properties of units in the cat's anterior auditory field (AAF) and compared them with those observed previously in the primary (A1) and posterior auditory fields (PAF). Multi-channel, silicon-substrate probes were used to record single- and multi-unit activity from the right hemispheres of alpha-chloralose-anesthetized cats. Spatial tuning was assessed using broadband noise bursts that varied in azimuth or elevation. Response latencies were slightly, though significantly, shorter in AAF than A1, and considerably shorter in both of those fields than in PAF. Compared to PAF, spike counts and latencies were more poorly modulated by changes in stimulus location in AAF and A1, particularly at higher sound pressure levels. Moreover, units in AAF and At demonstrated poorer level tolerance than units in PAF with spike rates modulated as much by changes in stimulus intensity as changes in stimulus location. Finally, spike-pattern-recognition analyses indicated that units in AAF transmitted less spatial information, on average, than did units in PAF-an observation consistent with recent evidence that PAF is necessary for sound-localization behavior, whereas AAF is not. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Harrington, Ian A.; Stecker, G. Christopher; Macpherson, Ewan A.; Middlebrooks, John C.] Univ Michigan, Kresge Hearing Res Inst, Cent Syst Lab, Ann Arbor, MI 48109 USA.
[Harrington, Ian A.] Augustana Coll, Dept Psychol, Rock Isl, IL 61201 USA.
[Stecker, G. Christopher] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
RP Middlebrooks, JC (reprint author), Univ Michigan, Kresge Hearing Res Inst, Cent Syst Lab, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM jmidd@umich.edu
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NR 60
TC 24
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 22
EP 41
DI 10.1016/j.heares.2008.02.004
PG 20
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500003
PM 18359176
ER
PT J
AU Basta, D
Goetze, R
Ernst, A
AF Basta, Dietmar
Goetze, Romy
Ernst, Arne
TI Effects of salicylate application on the spontaneous activity in brain
slices of the mouse cochlear nucleus, medial geniculate body and primary
auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus; sodium salicylate; cochlear nucleus; medial geniculate body;
auditory cortex; spontaneous activity; brain slice
ID INFERIOR COLLICULUS NEURONS; SODIUM-SALICYLATE; GUINEA-PIG;
ANIMAL-MODEL; SPINAL-CORD; RATS; TINNITUS; OTOTOXICITY; CAT; EXPRESSION
AB Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upon the changed afferent cochlear input to the central auditory system or in addition by a direct action of salicylate onto neurons within the auditory pathway.
A direct influence of local salicylate application on spontaneous activity of central auditory neurons has already been described for the inferior colliculus (IC) in brain slice preparations. As spontaneous activity within all key structures of the central auditory pathway could play an important role in tinnitus generation, the present study investigated direct effects of salicylate superfusion on the spontaneous activity of the deafferented cochlear nucleus (CN), medial geniculate body (MGB), and auditory cortex (AC) in brain slices.
Out of 72 neurons, 73.4% responded statistically significantly to the superfusate by changing their firing rates. 48.4% of them increased and 51.6% decreased their firing rates, respectively. The mean change of firing rate upon salicylate superfusion was 24.4%. All responses were not significantly different between the brain areas.
The amount of neurons which responded to salicylate and the mean change of firing rate was much higher in the IC than in the CN, MGB and AC. This contributes to the hypothesis that salicylate-induced tinnitus is a phantom auditory perception mainly related to hyperexcitability of IC neurons.
However, the present results suggest that the individual, specific salicylate sensitivity of CN, MGB and AC neurons can modulate the salicylate-induced generation of tinnitus. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Basta, Dietmar; Ernst, Arne] Univ Berlin, Charite Med Sch, Dept Otolaryngol, UKB, D-12683 Berlin, Germany.
[Basta, Dietmar; Goetze, Romy] Humboldt Univ, Inst Biol, D-10115 Berlin, Germany.
RP Basta, D (reprint author), Univ Berlin, Charite Med Sch, Dept Otolaryngol, UKB, Warener Str 7, D-12683 Berlin, Germany.
EM dietmar.basta@rz.hu-berlin.de
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NR 48
TC 12
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 42
EP 51
DI 10.1016/j.heares.2008.02.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500004
PM 18372130
ER
PT J
AU Izumikawa, M
Batts, SA
Miyazawa, T
Swiderski, DL
Raphael, Y
AF Izumikawa, Masahiko
Batts, Shelley A.
Miyazawa, Toru
Swiderski, Donald L.
Raphael, Yehoash
TI Response of the flat cochlear epithelium to forced expression of Atoh1
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; deafness; aminoglycosides; neomycin; adenovirus; guinea pig;
Atoh1; gene transfer
ID DAMAGED CHINCHILLA COCHLEA; MATURE GUINEA-PIGS; HAIR-CELLS; SUPPORTING
CELLS; GENE-TRANSFER; INNER-EAR; IN-VIVO; REGENERATION; ORGAN; CORTI
AB Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix-loop-helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. Forced expression of Atoh1 in the differentiated supporting cell population can induce transdifferentiation leading to hair cell regeneration. Here, we examined the outcome of adenovirus mediated over-expression of Atoh1 in the non-sensory cells of the flat epithelium. We determined that seven days after unilateral elimination of hair cells with neomycin, differentiated supporting cells are absent, replaced by a flat epithelium. Nerve processes were also missing from the auditory epithelium, with the exception of infrequent looping nerve processes above the habenula perforata. We then inoculated an adenovirus vector with Atoh1 insert into the scala media of the deafened cochlea. The inoculation resulted in upregulation of Atoh1 in the flat epithelium. However, two months after the inoculation, Atoh1-treated ears did not exhibit clear signs of hair cell regeneration. Combined with previous data on induction of supporting cell to hair cell transdiffierentiation by forced expression of Atoh1, these results suggest that the presence of differentiated supporting cells in the organ of Corti is necessary for transdifferentiation to occur. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Izumikawa, Masahiko; Batts, Shelley A.; Miyazawa, Toru; Swiderski, Donald L.; Raphael, Yehoash] Univ Michigan, Kresge Hearing Res Inst, Sch Med, Ann Arbor, MI 48109 USA.
[Izumikawa, Masahiko] Kansai Med Univ, Dept Otolaryngol, Osaka 5731191, Japan.
[Miyazawa, Toru] Kanazawa Med Univ, Dept Otolaryngol, Uchinada, Ishikawa 9200293, Japan.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, Sch Med, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
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NR 23
TC 49
Z9 55
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 52
EP 56
DI 10.1016/j.heares.2008.02.007
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500005
PM 18430530
ER
PT J
AU Schaette, R
Kempter, R
AF Schaette, Roland
Kempter, Richard
TI Development of hyperactivity after hearing loss in a computational model
of the dorsal cochlear nucleus depends on neuron response type
SO HEARING RESEARCH
LA English
DT Article
DE dorsal cochlear nucleus; computational model; hearing loss;
hyperactivity; auditory nerve; homeostatic plasticity
ID HAIR CELL LOSS; ENRICHED ACOUSTIC ENVIRONMENT; DEAFNESS ASSOCIATED
CHANGES; DOMAIN POTASSIUM CHANNELS; STEM AUDITORY NUCLEI; INFERIOR
COLLICULUS; INTENSE SOUND; BRAIN-STEM; GUINEA-PIG; HOMEOSTATIC
PLASTICITY
AB Cochlear damage can change the spontaneous firing rates of neurons in the dorsal cochlear nucleus (DCN). Increased spontaneous firing rates (hyperactivity) after acoustic trauma have been observed in the DCN of rodents such as hamsters, chinchillas and rats. This hyperactivity has been interpreted as a neural correlate of tinnitus. In cats, however, the spontaneous firing rates of DCN neurons were not significantly elevated after acoustic trauma. Species-specific spontaneous firing rates after cochlear damage might be attributable to differences in the response types of DCN neurons: In gerbils, type III response characteristics are predominant, whereas in cats type IV responses are more frequent. To address the question of how the development of hyperactivity after cochlear damage depends on the response type of DCN neurons, we use a computational model of the basic circuit of the DCN. By changing the strength of two types of inhibition, we can reproduce salient features of the responses of DCN neurons. Simulated cochlear damage, which decreases the activity of auditory nerve fibers, is assumed to activate homeostatic plasticity in projection neurons (PNs) of the DCN. We find that the resulting spontaneous firing rates depend on the response type of DCN PNs: PNs with type III and type IV-T response characteristics may become hyperactive, whereas type IV PNs do not develop increased spontaneous firing rates after acoustic trauma. This theoretical framework for the mechanisms and circumstances of the development of hyperactivity in central auditory neurons might also provide new insights into the development of tinnitus. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Schaette, Roland; Kempter, Richard] Humboldt Univ, Dept Biol, Inst Theoret Biol, D-10115 Berlin, Germany.
[Schaette, Roland; Kempter, Richard] Bernstein Ctr Computat Neurosci Berlin, D-10115 Berlin, Germany.
[Schaette, Roland; Kempter, Richard] Charite Univ Med Berlin, Neurosci Res Ctr, D-10117 Berlin, Germany.
RP Schaette, R (reprint author), Humboldt Univ, Dept Biol, Inst Theoret Biol, Invalidenstr 43, D-10115 Berlin, Germany.
EM r.schaette@biologie.hu-berlin.de
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NR 58
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 57
EP 72
DI 10.1016/j.heares.2008.02.006
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500006
PM 18396381
ER
PT J
AU Hsieh, IH
Saberi, K
AF Hsieh, I-Hui
Saberi, Kourosh
TI Dissociation of procedural and semantic memory in absolute-pitch
processing
SO HEARING RESEARCH
LA English
DT Article
DE music; absolute-pitch; memory
ID MUSICAL PITCH; CODING STRATEGIES; IDENTIFICATION; POSSESSORS
AB We describe two memory-retrieval systems in absolute-pitch (AP) processing and propose existence of a universal internal pitch template to which subpopulations of musicians selectively gain access through the two systems. In Experiment 1, AP and control musicians adjusted the frequency of a pure tone to match the pitch of a visually displayed randomly selected musical note. In Experiment 11 the same subjects vocally produced within 2 s the pitch associated with a randomly selected musical note label. AP musicians, but not controls, were highly accurate in frequency matching. Surprisingly, both AP and non-AP groups were extremely accurate in voicing the target pitch as determined from an FFT of the recorded voiced notes (i.e., sigma = 0.97, 0.90 semitones, respectively). Spectrogram analysis showed that notes voiced by non-AP musicians are accurate from onset of voicing suggesting that pitch accuracy does not result from an auditory-motor feedback loop. Findings support existence of two memory-retrieval systems for musical pitch: a semantic associative form of memory used by AP musicians, and a more widespread form of procedural memory which allows precise access to internal pitch representations through the vocal-motor system. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Saberi, Kourosh] Univ Calif Irvine, Dept Cognit Sci, Irvine, CA 92697 USA.
Univ Calif Irvine, Ctr Cognit Neurosci, Irvine, CA 92697 USA.
RP Saberi, K (reprint author), Univ Calif Irvine, Dept Cognit Sci, Irvine, CA 92697 USA.
EM saberi@uci.edu
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NR 22
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 73
EP 79
DI 10.1016/j.heares.2008.01.017
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500007
PM 18430531
ER
PT J
AU Ealy, M
Chen, WJ
Ryu, GY
Yoon, JG
Welling, DB
Hansen, M
Madan, A
Smith, RJH
AF Ealy, Megan
Chen, Wenjie
Ryu, Gi-Yung
Yoon, Jae-Geun
Welling, D. Bradley
Hansen, Marlan
Madan, Anup
Smith, Richard J. H.
TI Gene expression analysis of human otosclerotic stapedial footplates
SO HEARING RESEARCH
LA English
DT Article
DE otosclerosis; stapes; microarray; gene expression
ID ALPHA MESSENGER-RNA; MEASLES-VIRUS; HEARING-LOSS; BONE; COL1A1; LOCUS;
TRANSCRIPTION; ASSOCIATION; PROMOTER; ETIOLOGY
AB Otosclerosis is a complex disease that results in a common form of conductive hearing loss due to impaired mobility of the stapes. Stapedial motion becomes compromised secondary to invasion of otosclerotic foci into the stapedio-vestibular joint. Although environmental factors and genetic causes have been implicated in this process, the pathogenesis of otosclerosis remains poorly understood. To identify molecular contributors to otosclerosis we completed a microarray study of otosclerotic stapedial footplates. Stapes footplate samples from otosclerosis and control patients were used in the analysis. One-hundred-and-ten genes were found to be differentially expressed in otosclerosis samples. Ontological analysis of differentially expressed genes in otosclerosis provides evidence for the involvement of a number of pathways in the disease process that include interleukin signaling, inflammation and signal tramsduction, suggesting that aberrant regulation of these pathways leads to abnormal bone remodeling. Functional analyses of genes from this study will enhance our understanding of the pathogenesis of this disease. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Ealy, Megan; Chen, Wenjie; Smith, Richard J. H.] Univ Iowa, Div Nephrol, Dept Otolaryngol Pediat & Internal Med, Mol Otolaryngol Res Labs, Iowa City, IA 52242 USA.
[Ryu, Gi-Yung; Yoon, Jae-Geun; Madan, Anup] Univ Iowa, Dept Neurosurg, Neurogenom Res Lab, Iowa City, IA USA.
[Welling, D. Bradley] Ohio State Univ, Dept Otolaryngol Head & Neck Surg, Columbus, OH 43210 USA.
[Hansen, Marlan] Univ Iowa, Dept Otolaryngol, Iowa City, IA USA.
[Madan, Anup] Inst Syst Biol, Seattle, WA USA.
RP Smith, RJH (reprint author), Univ Iowa, Div Nephrol, Dept Otolaryngol Pediat & Internal Med, Mol Otolaryngol Res Labs, 200 Hawkins Dr,21151 PFP, Iowa City, IA 52242 USA.
EM richard_smith@uiowa.edu
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NR 33
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 80
EP 86
DI 10.1016/j.heares.2008.03.001
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500008
PM 18430532
ER
PT J
AU Matos, TD
Caria, H
Simoes-Teixeira, H
Aasen, T
Dias, O
Andrea, M
Kelsell, DP
Fialho, G
AF Matos, T. D.
Caria, H.
Simoes-Teixeira, H.
Aasen, T.
Dias, O.
Andrea, M.
Kelsell, D. P.
Fialho, G.
TI A novel M163L mutation in connexin 26 causing cell death and associated
with autosomal dominant hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE connexin 26; dominant; GJB2; deafness
ID GENE-MUTATIONS; DEAFNESS; GJB2; PATTERNS
AB Mutations in GJB2 gene (encoding connexin 26) are the most common cause of hereditary non-syndromic sensorineural hearing loss (NSSHL) in different populations. The majority of GJB2 mutations are recessive, but a few dominant mutations have been associated with hearing loss either isolated or associated with skin disease. We describe a novel dominant pathogenic GJB2 mutation, identified in a Portuguese family affected with bilateral mild/moderate high-frequency NSSHL. In vitro functional studies demonstrate that the mutant protein (p.M163L) has defective trafficking to the plasma membrane and is associated with increased cell death. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Matos, T. D.; Aasen, T.; Kelsell, D. P.] Univ London, Barts & London Sch Med & Dent, Inst Cell & Mol Sci, Ctr Cutaneous Res, London E1 4AT, England.
[Matos, T. D.; Caria, H.; Simoes-Teixeira, H.; Fialho, G.] Univ Lisbon, Fac Ciencias, Ctr Genet & Biol Mol, P-1749016 Lisbon, Portugal.
[Caria, H.] Inst Politecn Setubal, Escola Super Saude, P-2914503 Setubal, Portugal.
[Dias, O.; Andrea, M.] Hosp Santa Maria, Serv ORL, P-1649035 Lisbon, Portugal.
RP Kelsell, DP (reprint author), Univ London, Barts & London Sch Med & Dent, Inst Cell & Mol Sci, Ctr Cutaneous Res, London E1 4AT, England.
EM d.p.kelsell@qmul.ac.uk
RI Aasen, Trond/B-5279-2013
OI Aasen, Trond/0000-0003-0763-2695
CR BALLANA E, 2008, CONNEXINS DEAFNESS H
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Zhao HB, 2006, J COMP NEUROL, V499, P506, DOI 10.1002/cne.21113
NR 19
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 87
EP 92
DI 10.1016/j.heares.2008.03.004
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500009
PM 18472371
ER
PT J
AU Vinay
Moore, BCJ
AF Vinay
Moore, Brian C. J.
TI Effects of activation of the efferent system on psychophysical tuning
curves as a function of signal frequency
SO HEARING RESEARCH
LA English
DT Article
DE efferent system; psychophysical tuning curves; contralateral stimulation
ID CROSSED OLIVOCOCHLEAR BUNDLE; BASILAR-MEMBRANE RESPONSES; AUDITORY-NERVE
RESPONSE; GUINEA-PIG COCHLEA; INTENSITY DISCRIMINATION;
ELECTRICAL-STIMULATION; NONLINEAR MECHANICS; CHINCHILLA COCHLEA; HUMANS;
NOISE
AB it has been shown that electrical stimulation of the efferent auditory system can influence neural tuning curves in animals. Here, we examined a psychophysical analog of this effect in humans. All of the 19 normally hearing subjects showed a reduction in the amplitude of otoacoustic emissions in one ear when contralateral broadband noise was presented, indicating a functioning efferent system. Psychophysical tuning curves (PTCs) were measured in simultaneous masking in the absence and presence of contralateral stimulation (CS). The CS was a continuous narrowband noise centered at the signal frequency and presented at a level of 50 or 60 dB SL. The CS had no consistent effect on the masker level at the tips of the PTCs. For the two highest signal frequencies (2000 and 4000 Hz), the CS reduced the masker level required for threshold on both the low- and high-frequency sides of the PTCs, and the sharpness of tuning, as measured by Q10, decreased significantly. For the two lowest signal frequencies (500 and 1000 Hz), the masker level required for threshold on the low-frequency sides of the PTCs increased with CS, and the Q10 values increased significantly. The general pattern of the results was consistent with that observed for electrical stimulation of the efferent system in animals. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Vinay] All India Inst Speech & Hearing, Mysore 570006, Karnataka, India.
[Moore, Brian C. J.] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Vinay (reprint author), 231 Shri Vinyasa,9th Cross,5th Main Vijayanagar 1, Mysore 570017, Karnataka, India.
EM shrivinyasa@gmail.com
RI Moore, Brian/I-5541-2012
CR ANSI, 2004, S362004 ANSI
British Society of Audiology, 2004, PUR TON AIR BON COND
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NR 36
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 93
EP 101
DI 10.1016/j.heares.2008.03.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500010
PM 18440738
ER
PT J
AU Adler, HJ
Sanovich, E
Brittan-Powell, EF
Yan, K
Dooling, RJ
AF Adler, Henry J.
Sanovich, Elena
Brittan-Powell, Elizabeth F.
Yan, Kai
Dooling, Robert J.
TI WDR1 presence in the songbird basilar papilla
SO HEARING RESEARCH
LA English
DT Article
DE RT-PCR; immunocytochemistry; confocal microscopy; Belgian Waterslager
canary; hearing; acoustic trauma; genetic hearing loss
ID ACTIN-INTERACTING PROTEIN-1; HAIR-CELL REGENERATION; CANARIES
SERINUS-CANARIUS; CHICK INNER-EAR; LIGHT-MICROSCOPIC EVIDENCE;
VESTIBULAR OTOLITH ORGANS; SEVERE ACOUSTIC TRAUMA; TECTORIAL MEMBRANE;
INTENSE SOUND; DEPOLYMERIZING FACTOR/COFILIN
AB WD40 repeat 1 protein (WDR1) was first reported in the acoustically injured chicken inner ear, and bio-informatics revealed that WDR1 has numerous WD40 repeats, important for protein-protein interactions. It has significant homology to actin interacting protein 1 (Aip1) in several lower species such as yeast, roundworm, fruitfly and frog. Several studies have shown that Aip1 binds cofilin/actin depolymerizing factor, and that these interactions are pivotal for actin disassembly via actin filament severing and actin monomer capping. However, the role of WDR1 in auditory function has yet to be determined.
WDR1 is typically restricted to hair cells of the normal avian basilar papilla, but is redistributed towards supporting cells after acoustic overstimulation, suggesting that WDR1 may be involved in inner ear response to noise stress. One aim of the present study was to resolve the question as to whether stress factors, other than intense sound, could induce changes in WDR1 presence in the affected avian inner ear. Several techniques were used to assess WDR1 presence in the inner ears of songbird strains, including Belgian Waterslager (BW) canary, an avian strain with degenerative hearing loss thought to have a genetic basis. Reverse transcription, followed by polymerase chain reactions with WDR1-specific primers, confirmed WDR1 presence in the basilar papillae of adult BW, non-BW canaries, and zebra finches. Confocal microscopy examinations, following immunocytochemistry with anti-WDR1 antibody, localized WDR1 to the hair cell cytoplasm along the avian sensory epithelium. In addition, little, if any, staining by anti-WDR1 antibody was observed among supporting cells in the chicken or songbird ear.
The present observations confirm and extend the early findings of WDR1 localization in hair cells, but not in supporting cells, in the normal avian basilar papilla. However, unlike supporting cells in the acoustically damaged chicken basilar papilla, the inner ear of the BW canary showed little, if any, WDR1 upregulation in supporting cells. This may be due to the fact that the BW canary already has established hearing loss and/or to the possibility that the mechanism(s) involved in BW hearing loss may not be related to WDR1. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Adler, Henry J.; Sanovich, Elena; Brittan-Powell, Elizabeth F.; Yan, Kai; Dooling, Robert J.] Univ Maryland, Ctr Comparat & Evolutionary Biol Hearing, College Pk, MD 20742 USA.
[Adler, Henry J.; Yan, Kai] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Sanovich, Elena; Brittan-Powell, Elizabeth F.; Dooling, Robert J.] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
RP Adler, HJ (reprint author), Univ Maryland, Ctr Comparat & Evolutionary Biol Hearing, 4212 Biol Psychol Bldg, College Pk, MD 20742 USA.
EM hadler@umd.edu
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NR 83
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 102
EP 111
DI 10.1016/j.heares.2008.03.008
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500011
PM 18514449
ER
PT J
AU Jump, RL
Ries, DT
AF Jump, Rebecca L.
Ries, Dennis T.
TI Effect of interaural level and phase cues on intervening interference in
auditory working memory for loudness
SO HEARING RESEARCH
LA English
DT Article
DE intensity; loudness; just noticeable difference; auditory working memory
ID SHORT-TERM-MEMORY; RECOGNITION MEMORY; PITCH-MEMORY; RETROACTIVE
INTERFERENCE; TONAL PITCH; TONES; INTENSITY; EAR; REPETITION; INPUT
AB The focus of this study was to gauge the influence of intervening interference on an intensity standard held within auditory working memory through measurement of the just noticeable difference (JND) for intensity. Additionally, the use of interaural phase differences and interaural level differences as spatial cues were employed to identify whether these indicators provided a means for release from interference. A series of tones, both with and without spatial cues, were presented to subjects and responses were obtained using the method of constant stimuli. The JND for intensity was measured in a control condition with a silent inter-comparison interval and three conditions containing intervening tones within the temporal gap between the standard and comparison stimuli. The presence of intervening interference produced a significant increase in the intensity difference needed for discrimination. Further, the provision of spatial cues did not result in a significant release from this interference. These results indicate that a release from interference is not obtained when listeners are required to rely entirely on information used for spatial location (i.e., overall intensity differences and interaural phase/intensity differences) without unique information identifying the sound source to aid in retention of relevant information within auditory working memory. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Jump, Rebecca L.; Ries, Dennis T.] Ohio Univ, Sch Hearing Speech & Language Sci, Auditory Percept Lab, Grover Ctr W241, Athens, OH 45701 USA.
RP Jump, RL (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Auditory Percept Lab, Grover Ctr W241, Athens, OH 45701 USA.
EM rj151000@ohio.edu; ries@ohio.edu
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NR 30
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2008
VL 240
IS 1-2
BP 112
EP 115
DI 10.1016/j.heares.2008.04.004
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 324PW
UT WOS:000257531500012
PM 18514450
ER
PT J
AU Won, JH
Schimmel, SM
Drennan, WR
Souza, PE
Atlas, L
Rubinstein, JT
AF Won, Jong Ho
Schimmel, Steven M.
Drennan, Ward R.
Souza, Pamela E.
Atlas, Les
Rubinstein, Jay T.
TI Improving performance in noise for hearing aids and cochlear implants
using coherent modulation filtering
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 149th Meeting of the Acoustical-Society-of-America
CY MAY 16-20, 2005
CL Vancouver, CANADA
SP Acoust Soc Amer
DE coherent modulation filter; speech enhancement; hearing aids; cochlear
implants
ID AUDITORY-CORTEX; SPEECH RECOGNITION; FREQUENCY; AMPLITUDE; PERIODICITY;
PERCEPTION; LISTENERS; CAT
AB This study evaluated the maximal attainable performance of speech enhancement strategies based on coherent modulation filtering. An optimal adaptive coherent modulation filtering algorithm was designed to enhance known signals from a target talker in two-talker babble noise. The algorithm was evaluated in a closed-set, speech-recognition-in-noise task. The speech reception threshold (SRT) was measured using a one-down, one-up adaptive procedure. Five hearing-impaired subjects and five cochlear implant users were tested in three processing conditions: (1) original sounds; (2) fixed coherent modulation filtered sounds; and (3) optimal coherent modulation filtered sounds. Six normal-hearing subjects were tested with a 6-channel cochlear implant simulation of sounds processed in the same three conditions. Significant improvements in SRTs were observed when the signal was processed with the optimal coherent modulation filtering algorithm. There was no benefit when the signal was processed with the fixed modulation filter. The current study suggested that coherent modulation filtering might be a promising method for front-end processing in hearing aids and cochlear implants. An approach such as hidden Markov models could be used to generalize the optimal coherent modulation filtering algorithm to unknown utterances and to extend it to open-set speech.(c) 2008 Elsevier B.V. All rights reserved.
C1 [Won, Jong Ho; Schimmel, Steven M.; Drennan, Ward R.; Souza, Pamela E.; Atlas, Les; Rubinstein, Jay T.] Univ Washington, VM Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
[Drennan, Ward R.; Rubinstein, Jay T.] Washington Univ, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63130 USA.
[Won, Jong Ho; Rubinstein, Jay T.] Washington Univ, Dept Bioengn, St Louis, MO 63130 USA.
[Schimmel, Steven M.; Atlas, Les] Washington Univ, Dept Elect Engn, St Louis, MO 63130 USA.
[Souza, Pamela E.] Washington Univ, Dept Speech & Hearing Sci, St Louis, MO 63130 USA.
RP Won, JH (reprint author), Univ Washington, VM Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA.
EM jhwon@u.washington.edu
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NR 36
TC 7
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 1
EP 11
DI 10.1016/j.heares.2008.01.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700001
PM 18295993
ER
PT J
AU Jaeger, R
Kondrachuk, AV
Haslwanter, T
AF Jaeger, R.
Kondrachuk, A. V.
Haslwanter, T.
TI The distribution of otolith polarization vectors in mammals: Comparison
between model predictions and single cell recordings
SO HEARING RESEARCH
LA English
DT Article
DE otolith; hair cells; vestibular; modeling
ID PERIPHERAL INNERVATION PATTERNS; VESTIBULAR SENSORY EPITHELIA;
DIRECTIONAL SENSITIVITY; DISCHARGE PROPERTIES; UTRICULAR MACULA;
SQUIRREL-MONKEY; HAIR BUNDLES; CHINCHILLA; ORGANS; NERVE
AB The transformation of head-movements into neural signals represents a multi-stage process. It depends on orientation and movement of the head, the geometry and mechanics of the vestibular sensors, and the ensuing processing of the peripheral vestibular signals. While this process is well understood for the semicircular canals, where each canal transduces the angular velocity in the corresponding canal plane, the contributions of the individual otoliths, our linear acceleration sensors, are still under debate. This is in part due to the complex geometrical structure of the otoliths. To improve our understanding of the otoliths, we have developed a new technique to visualize otolith function: using measured 3D-shapes of human otoliths and the observed 2D patterns of hair cell orientation over the epithelia, morphological polarization vectors are predicted. To visualize the geometric distribution of these vectors, we have created distribution plots which indicate the density of hair cell polarization vectors for the different directions. In many respects, our results closely agree with earlier recordings of polarization vectors of vestibular afferents in squirrel monkeys: for example, hair cells on the saccule do not cover the sagittal plane equally, but show a strong concentration in the dorso-ventral directions. Some discrepancies exist in the density distribution of otolith, which could provide valuable information for future anatomical investigations of the otoliths. (c) 2008 Published by Elsevier B.V.
C1 [Jaeger, R.] Univ Tubingen, Dept Theoret Astrophys, D-72076 Tubingen, Germany.
[Kondrachuk, A. V.] Natl Acad Sci Ukraine, Inst Phys, Dept Theoret Phys, UA-03028 Kiev, Ukraine.
[Haslwanter, T.] Upper Austrian Univ Appl Sci, A-4020 Linz, Austria.
[Haslwanter, T.] Upper Austrian Res, Dept Med Informat, A-4020 Linz, Austria.
RP Jaeger, R (reprint author), Univ Tubingen, Dept Theoret Astrophys, Morgenstelle 10, D-72076 Tubingen, Germany.
EM rudijaeger@yahoo.com; kondr@kondr.kiev.ua; Thomas.Haslwanter@fh-linz.at
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NR 26
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 12
EP 19
DI 10.1016/j.heares.2008.01.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700002
PM 18316166
ER
PT J
AU Ma, KT
Guan, BC
Yang, YQ
Zhao, H
Jiang, ZG
AF Ma, Ke-Tao
Guan, Bing-Cai
Yang, Yu-Qin
Zhao, Hui
Jiang, Zhi-Gen
TI ACh-induced depolarization in inner ear artery is generated by
activation of a TRP-like non-selective cation conductance and
inactivation of a potassium conductance
SO HEARING RESEARCH
LA English
DT Article
DE membrane potential; intracellular recording; whole-cell recording; TRP
channel; inward rectifier potassium channel; arteriole
ID SMOOTH-MUSCLE-CELLS; SPIRAL MODIOLAR ARTERY; RECEPTOR POTENTIAL
CHANNELS; ENDOTHELIAL-CELLS; COCHLEAR ARTERY; RABBIT AORTA; SUBSTANCE-P;
K+ CHANNELS; MYOCYTES; INWARD
AB Adequate cochlear blood supply by the spiral modiolar artery (SMA) is critical for normal hearing. ACh may play a role in neuroregulation of the SMA but several key issues including its membrane action mechanisms remain poorly understood. Besides its well-known endothelium-dependent hyperpolarizing action, ACh can induce a depolarization in vascular cells. Using intracellular and whole-cell recording techniques on cells in guinea pig in vitro SMA, we studied the ionic mechanism underlying the ACh-depolarization and found that: (1) ACh induced a DAMP-sensitive depolarization when intermediate conductance K-Ca channels were blocked by charybdotoxin or nitrendipine. The ACh-depolarization was associated with a decrease in input resistance (R-input) in high membrane potential (V,) (similar to-40 mV) cells but with no change or an increase in R-input in low V-m (similar to 75 mV) cells. ACh-depolarization was attenuated by background membrane depolarization from similar to-70 mV in the majority of cells; (2) ACh-induced inward current in smooth muscle cells embedded in a SMA segment often showed a U-shaped I/V curve, the reversal potential of its two arms being near E-K and 0 mV, respectively; (3) ACh-depolarization was reduced by low Na+, zero K+ or 20 mM K+ bath solutions; (4) ACh-depolarization was inhibited by La3+ in all cells tested, by 4-AP and flufenamic acid in low V-m cells, but was not sensitive to Cd2+, Ni2+, nifedipine, niflumic acid, DIDS, IAA94, linopirdine or amiloride. We conclude that ACh-induced vascular depolarization was generated mainly by activation of a TRP-like nonselective cation channel and by inactivation of an inward rectifier K+ channel. Published by Elsevier B.V.
C1 [Ma, Ke-Tao; Guan, Bing-Cai; Yang, Yu-Qin; Zhao, Hui; Jiang, Zhi-Gen] Oregon Hlth & Sci Univ, Dept Otolaryngol, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
[Ma, Ke-Tao] Shihezi Univ Med Coll, Dept Physiol, Xinjiang, Peoples R China.
[Ma, Ke-Tao] Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Wuhan, Hubei, Peoples R China.
[Zhao, Hui] Fudan Univ, Eye Ear Nose & Throat Hosp, Dept Otolaryngol, Shanghai 200433, Peoples R China.
RP Jiang, ZG (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
EM jiangz@ohsu.edu
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NR 51
TC 2
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 20
EP 33
DI 10.1016/j.heares.2008.01.005
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700003
PM 18313244
ER
PT J
AU Lineton, B
Kuponiyi, O
Thornton, ARD
AF Lineton, Ben
Kuponiyi, Omolara
Thornton, A. Roger D.
TI The effect of stimulus rate and time-separation on Volterra slices of
otoacoustic emissions
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; maximum length sequences; non-linearity temporal
interaction; Volterra series
ID MAXIMUM LENGTH SEQUENCES; ACOUSTIC EMISSIONS; AUDITORY-SYSTEM;
NONLINEARITIES; HEARING; SERIES; CLICKS
AB Volterra slices (VSs) of otoacoustic emissions are temporal non-linear interaction components which can be measured using the maximum length sequence technique of stimulation. Previous studies have found, but not explained, non-monotonic variations in the amplitude of VSs when stimulus rate is increased. In this study, a simple phenomenological model is investigated which provided possible insights into the effect of rate on VS amplitudes. Resulting theoretical considerations suggest that the effect of rate on VS amplitude is best examined when the time-separation parameter of the VS is held constant. To test these suggestions, data on VSs of order 2 and 3 were measured in 24 normal hearing ears in which the rate is varied while holding constant the time-separation. Under these conditions, the results reveal a monotonic reduction in the amplitude of the VSs with increasing rate. The phenomenological model offers a possible explanation of some of these results in terms of the derivatives of the input-output function of the non-linearity. In addition, measured cross-correlations between waveforms of VS of different order and slice number were obtained, revealing a complex dependence on time-separation that has not been explained. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Lineton, Ben; Kuponiyi, Omolara; Thornton, A. Roger D.] Royal S Hants Hosp, MRC Inst Hearing Res, Southampton SO14 0YG, Hants, England.
RP Lineton, B (reprint author), Royal S Hants Hosp, MRC Inst Hearing Res, Southampton SO14 0YG, Hants, England.
EM b.lineton@soton.ac.uk
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NR 20
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 34
EP 53
DI 10.1016/j.heares.2008.01.006
PG 20
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700004
PM 18328651
ER
PT J
AU Patel, MR
Stamat, JC
Zdanski, CJ
Ebert, CS
Prazma, J
AF Patel, Mihir R.
Stamat, Jocelyn C.
Zdanski, Carlton J.
Ebert, Charles S., Jr.
Prazma, Jiri
TI Nitric oxide in glutamate-induced compound action potential threshold
shifts
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; excitatory amino acids; glutamate; nitric oxide;
7-nitroindazole; excitotoxicity
ID KAINIC ACID; SODIUM-NITROPRUSSIDE; COCHLEAR POTENTIALS;
CEREBRAL-ISCHEMIA; GUINEA-PIG; SYNTHASE; CELLS; EXCITOTOXICITY;
PHARMACOLOGY; SUPEROXIDE
AB Objective: Investigate the role of NO as a neuro transmitter in the gerbil cochlea and the effects of (7-NI) on compound action potential (CAP) threshold elevations induced by L-glutamate, an agonist at the NMDA glutamate receptor subtype, to further elucidate the role of NO in cochlear excitotoxicity.
Method: In anesthetized gerbils, CAP thresholds were recorded before and after cochlear perfusions with a control solution of artificial perilymph (APS) and a test solution Of L-glutamate (GA) in three experimental groups.
Results: The control group showed no CAP threshold elevations (p < 0.05) when APS was perfused after systemic pre-treatment with 7-NI. GA perfusion alone caused significant elevation (p < 0.05) of the mean cochlear CAP threshold (25 dB SPL +/- 5.8 dB to 78 dB SPL +/- 19.5 dB). The CAP threshold elevation was prevented (p < 0.05) when the animals were pretreated with 7-NI before GA perfusion (24 dB SPL +/- 4.2 dB to 27 dB SPL +/- 6.7 dB).
Conclusion: NO mediates excitotoxicity when the cochlea is perfused with L-glutamate. (c) 2008 Published by Elsevier B.V.
C1 [Patel, Mihir R.; Zdanski, Carlton J.; Ebert, Charles S., Jr.; Prazma, Jiri] Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
[Stamat, Jocelyn C.] Northwestern Univ, Mcgaw Med Ctr, Chicago, IL 60611 USA.
RP Zdanski, CJ (reprint author), Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Bioinformat Bldg CB 7070, Chapel Hill, NC 27599 USA.
EM carlton_zdanski@med.unc.edu
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NR 25
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 54
EP 59
DI 10.1016/j.heares.2008.01.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700005
PM 18434048
ER
PT J
AU Gnansia, D
Jourdes, V
Lorenzi, C
AF Gnansia, Dan
Jourdes, Vincent
Lorenzi, Christian
TI Effect of masker modulation depth on speech masking release
SO HEARING RESEARCH
LA English
DT Article
DE speech intelligibility; background noise; masking release; glimpsing;
modulation depth; temporal fine structure
ID NORMAL-HEARING LISTENERS; COCHLEAR IMPLANT USERS; NERVE FIBER RESPONSES;
FLUCTUATING NOISE; CONSONANT IDENTIFICATION; RECEPTION THRESHOLD;
FINE-STRUCTURE; INTELLIGIBILITY INDEX; INTERFERING SPEECH; TEMPORAL DIPS
AB Consonant identification was measured for normal-hearing listeners using nonsense Vowel-Consonant-Vowel (VCV) stimuli embedded in a steady-state or fluctuating noise masker and presented at a fixed, global signal-to-noise ratio (SNR) yielding 50% correct identification for steady noise. Fluctuations in the masker were obtained by applying sinusoidal amplitude modulation to the noise. VCVs and noise were either left intact (unprocessed) or degraded by removing temporal fine structure (TFS) cues within 32 frequency bands with bandwidths chosen to match psychophysical estimates of auditory filter bandwidth. For unprocessed stimuli, masking release (MR) - that is better identification in fluctuating than in steady noise - was observed at both masker frequencies tested (8 and 32 Hz). MR increased monotonically and similarly with the modulation depth in of the noise masker (from m = 12.5% to 100%) at both masker modulation frequencies. The effect of masker modulation depth on release was different for reception of place of articulation and reception of voicing and manner. The effect of masker modulation depth on release was also significantly affected when TFS cues were removed. These data provide evidence that listeners "glimpse" into noise valleys where maximum SNR may be as low as -5 dB (m = 12.5%), and suggest a specific contribution of TFS cues to the glimpsing process. (c) 2008 Elsevier B. V. All rights reserved.
C1 [Gnansia, Dan; Lorenzi, Christian] Ecole Normale Super, Dept Etud Cognit, Equipe Audit, F-75005 Paris, France.
[Gnansia, Dan; Lorenzi, Christian] Univ Paris 05, UMR CNRS 8158, Lab Psychol Percept, F-75006 Paris, France.
[Gnansia, Dan; Jourdes, Vincent; Lorenzi, Christian] ENS, GDR CNRS GRAEC 2967, F-75005 Paris, France.
[Gnansia, Dan; Jourdes, Vincent] Sophia Antipolis, MXM Neurelec, F-06224 Vallauris, France.
RP Gnansia, D (reprint author), Ecole Normale Super, Dept Etud Cognit, Equipe Audit, 29 Rue Ulm, F-75005 Paris, France.
EM dan.gnansia@ens.fr
RI Lorenzi, Christian/F-5310-2012
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NR 49
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 60
EP 68
DI 10.1016/j.heares.2008.01.012
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700006
PM 18434049
ER
PT J
AU Bektas, D
Martin, GK
Stagner, BB
Lonsbury-Martin, BL
AF Bektas, Devrim
Martin, Glen K.
Stagner, Barden B.
Lonsbury-Martin, Brenda L.
TI Noise-induced hearing loss in mice treated with antiretroviral drugs
SO HEARING RESEARCH
LA English
DT Article
DE CBA/CaJ mice; HIV; AIDS; ototoxicity; nucleoside reverse transcriptase
inhibitors; zidovudine; lamivudine; distortion product otoacoustic
emissions; octave-band noise exposure; auditory brainstem responses;
synergistic effects
ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; REVERSE-TRANSCRIPTASE INHIBITORS;
MITOCHONDRIAL RIBOSOMAL-RNA; INFECTED PATIENTS; AUDITORY FUNCTION;
INDUCED DEAFNESS; TEMPORAL BONE; OTOTOXICITY; VIRUS; INHERITANCE
AB The results reported here for CBA/CaJ mice describe the effects of regular dosing with a common antiretroviral drug combination on outer hair cell (OHC) function using measures of 2f(1)-f(2) distortion product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABRs). Specifically, experimental mice were treated daily over a 3-mo period with the nucleoside reverse transcriptase inhibitors (NRTIs), zidovudine (ZDV) and lamivudine (3TC), dissolved in their drinking water, while their control counterparts received untreated water. DPOAE levels and ABR detection thresholds prior to and after 12 wk of NRTI treatment did not differ between experimental and control groups. To assess whether NRTI treatment potentiates the adverse effects of noise over-exposure on OHC function, both experimental and control mice were exposed I wk later, while still on the drug regimen, to a 10-kHz octave-band noise (OBN) at 105-dB SPL for I h. A major outcome of the sound over-exposure episode was that the NRTI-pretreated mice showed significantly greater permanent OBN-induced reductions in DPOAE levels at 2 wk postexposure than were observed for the untreated control animals. These findings support the notion that a synergistic relationship exists between certain NRTls and intense sounds in that such pre-exposure drug treatments produced greater noise-induced decreases in DPOAE activity than did noise exposure alone. This drug/noise interaction is consistent with the known harmful effects of NRTls on cellular mitochondrial activity. (c) 2008 Elsevier B. V. All rights reserved.
C1 [Martin, Glen K.; Stagner, Barden B.; Lonsbury-Martin, Brenda L.] VA Loma Linda Healthcare Syst, Res Serv 151, Loma Linda, CA 92357 USA.
[Bektas, Devrim] Karadeniz Tech Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Trabzon, Turkey.
[Martin, Glen K.; Lonsbury-Martin, Brenda L.] Loma Linda Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Loma Linda, CA USA.
RP Martin, GK (reprint author), VA Loma Linda Healthcare Syst, Res Serv 151, 11201 Benton St, Loma Linda, CA 92357 USA.
EM glen.martin2@va.gov
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NR 52
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 69
EP 78
DI 10.1016/j.heares.2008.01.016
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700007
PM 18384985
ER
PT J
AU Guthrie, OW
Li-Korotky, HS
Durrant, JD
Balaban, C
AF Guthrie, O'neil W.
Li-Korotky, Ha-Sheng
Durrant, John D.
Balaban, Carey
TI Cisplatin induces cytoplasmic to nuclear translocation of nucleotide
excision repair factors among spiral ganglion neurons
SO HEARING RESEARCH
LA English
DT Article
DE nucleotide excision repair; cisplatin; spiral ganglion neurons;
xeroderma pigmentosum; ototoxicity; DNA adduct
ID TEMPORAL BONE HISTOPATHOLOGY; PLATINUM-BASED CHEMOTHERAPY;
GLUTATHIONE-S-TRANSFERASE; DNA-REPAIR; GENE-EXPRESSION; CANCER-PATIENTS;
HUMAN-CELLS; ADDUCTS; DAMAGE; XPA
AB Genomic DNA is a high-affinity target for the antineoplastic molecule cisplatin. Cell survival from cisplatin DNA damage is dependent on removal of cisplatin-DNA adducts by nucleotide excision repair (NER) pathways. The rate-limiting steps in the NER pathways are DNA damage identification and verification. These steps are accomplished by xeroderma pigmentosum complementation group C and A (XPC and XPA) and RNA polymerase II. Unlike RNA polymerase 11, XPC and XPA have no known cellular function beyond DNA repair. Cisplatin is known to damage spiral ganglion neurons at the basal coil of the cochlea therefore it was posited that cisplatin may target their DNA and mobilize XPC and XPA. Female Fisher344 rats were given two, four day cycles of cisplatin (2 mg/kg) or saline, separated by a 10 day rest period. A 2 x 3 x 2 factorial design, consisting of two treatment conditions (cisplatin and saline treatment), three survival times (5, 19 and 22 days) and two analysis methods (quantitative RT-PCR and immunohistochemistry) was employed to evaluate the expression and distribution of XPC and XPA. Quantitative RT-PCR revealed statistically significant differerices in cochlear XPC and XPA mRNA levels after cisplatin treatment at all times except day 22 for XPA. Immunohistochemistry revealed that a proportion (similar to 50%) of spiral ganglion neurons in control rats showed cytoplasmic expression of XPC and XPA. After cisplatin treatment, a similar proportion (similar to 50%) of spiral ganglion neurons showed increased nuclear expression of XPC and XPA, which appears to represent translocation from the cytoplasm. Basal coil spiral ganglion neurons translocated XPC and XPA at later treatment cycles and with less magnitude than apical coil neurons after cisplatin treatment. Therefore, it is suggested that cisplatin treatment induces nuclear translocation of NER proteins among spiral ganglion neurons and that this nuclear translocation is less efficient at the base relative to the apex. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Guthrie, O'neil W.] Duke Univ, French Family Sci Ctr, Dev Cell & Mol Biol Grp, Dept Biol, Durham, NC 27708 USA.
[Guthrie, O'neil W.; Li-Korotky, Ha-Sheng; Durrant, John D.; Balaban, Carey] Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA 15260 USA.
[Guthrie, O'neil W.; Li-Korotky, Ha-Sheng; Durrant, John D.; Balaban, Carey] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15213 USA.
[Balaban, Carey] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15213 USA.
RP Guthrie, OW (reprint author), Duke Univ, French Family Sci Ctr, Dev Cell & Mol Biol Grp, Dept Biol, Sci Dr,Rm 4337,POB 90338, Durham, NC 27708 USA.
EM owg@duke.edu
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NR 53
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 79
EP 91
DI 10.1016/j.heares.2008.01.013
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700008
PM 18329831
ER
PT J
AU Ito, M
Hatano, M
Okoyama, S
Kelly, JB
AF Ito, Makoto
Hatano, Miyako
Okoyama, Shigeo
Kelly, Jack B.
TI Anatomical plasticity in brainstem auditory nuclei following unilateral
ablation of the inferior colliculus in neonatal rats
SO HEARING RESEARCH
LA English
DT Article
DE inferior colliculus (IC); superior olivary complex (SOC); retrograde
transport; [H-3]-glycine; fluoro-gold (FG)
ID SUPERIOR OLIVARY COMPLEX; FERRET MUSTELA-PUTORIUS; NORTH-AMERICAN
OPOSSUM; KAINIC ACID LESIONS; SOUND LOCALIZATION; LATERAL LEMNISCUS;
ALBINO-RAT; ASCENDING PROJECTIONS; AFFERENT-PROJECTIONS; BINAURAL
RESPONSES
AB Anatomical plasticity of projections from brainstem auditory structures to the inferior colliculus (IC) was examined in albino rats to determine the effects of unilateral destruction of the IC during early development. The IC in the right hemisphere was destroyed by aspiration on postnatal day 3. Upon reaching adulthood, the rats were examined by retrograde tract tracing methods with fluoro-gold (FG) and [H-3]-glycine to determine patterns of brainstem projections to the undamaged left IC. In our FG experiments, the results confirmed the presence of aberrant crossed projections from the right medial superior olive (MSO) to the undamaged left IC. Following injections of [H-3]-glycine or FG into the undamaged left IC, however, no other aberrant projections were found in the superior olive, including those from the ipsilateral lateral superior olive (LSO) or the superior paraolivary nucleus (SPN). These results suggest that projections from the MSO to the IC may have the latent ability to create aberrant crossed projections during development. On the other hand, the neurons in LSO and SPN do not form aberrant projections following early unilateral IC lesions. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Ito, Makoto; Hatano, Miyako] Kanazawa Univ, Grad Sch Med Sci, Div Neurosci, Dept Otolaryngol, Kanazawa, Ishikawa 9208640, Japan.
[Okoyama, Shigeo] Kanazawa Univ, Grad Sch Med Sci, Div Neuroanat, Ctr Biomed Res & Educ, Kanazawa, Ishikawa 9208640, Japan.
[Kelly, Jack B.] Carleton Univ, Dept Psychol, Lab Sensory Neurosci, Ottawa, ON K1S 5B6, Canada.
RP Ito, M (reprint author), Kanazawa Univ, Grad Sch Med Sci, Div Neurosci, Dept Otolaryngol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208640, Japan.
EM makoto@med.kanazawa-u.ac.jp
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NR 40
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 92
EP 98
DI 10.1016/j.heares.2008.01.014
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700009
PM 18343611
ER
PT J
AU Hamernik, RP
Qiu, W
Davis, B
AF Hamernik, Roger P.
Qiu, Wei
Davis, Bob
TI The effectiveness of N-acetyl-L-CySteine (L-NAC) in the prevention of
severe noise-induced hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE L-NAC; hearing loss; noise trauma
ID CHINCHILLA; ACETYLCYSTEINE; PROTECTION; EXPOSURES; COCHLEA
AB Three groups of chinchillas were exposed to a nonGaussian continuous broadband noise at an Leq = 105 dB SPL, 8 h/d for 5 d. One group (N = 6) received only the noise. A second group (N = 6) received the noise and was additionally treated with L-NAC (325 mg/kg, i.p.). Treatment was administered twice daily for 2 d prior to exposure and for 2 d following the exposure. During exposure the animals received the L-NAC just prior to and immediately after each daily exposure. The third group (N = 4) was exposed to the noise and received saline injections on the same schedule as the L-NAC treated animals. Auditory evoked potential recordings from the inferior colliculus were used to estimate pure tone thresholds and surface preparations of the organ of Corti quantified the sensory cell population. In all three groups PTS exceeded 50 dB at 2.0 kHz and above with severe sensory cell loss in the basal half of the cochlea. There was no statistically significant difference among the three groups in all measures of noise-induced trauma. Treatment with L-NAC did not reduce the trauma produced by a high-level, long duration, broadband noise exposure. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Hamernik, Roger P.; Qiu, Wei; Davis, Bob] SUNY Coll Plattsburgh, Audit Res Lab, Plattsburgh, NY 12901 USA.
RP Hamernik, RP (reprint author), SUNY Coll Plattsburgh, Audit Res Lab, 107 Beaumont Hall,101 Broad St, Plattsburgh, NY 12901 USA.
EM roger.hamernik@plattsburgh.edu
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NR 17
TC 12
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 99
EP 106
DI 10.1016/j.heares.2008.02.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700010
PM 18329204
ER
PT J
AU Yin, SK
Feng, YM
Chen, ZN
Wang, J
AF Yin, Shan-Kai
Feng, Yan-Mei
Chen, Zheng-Nong
Wang, Jian
TI The effect of noise-induced sloping high-frequency hearing loss on the
gap-response in the inferior colliculus and auditory cortex of guinea
pigs
SO HEARING RESEARCH
LA English
DT Article
DE gap-evoked response; high-frequency hearing loss; acoustic
over-stimulation; inferior colliculus; auditory cortex; guinea pig
ID STARLING STURNUS-VULGARIS; ACUTE COCHLEAR DAMAGE; EAR OSSICLE REMOVAL;
VOICE ONSET TIME; BRAIN-STEM; IMPAIRED LISTENERS; ACOUSTIC TRAUMA;
INTENSITY DISCRIMINATION; TEMPORAL RESOLUTION; UNILATERAL COCHLEAR
AB Gap detection has been used as an evaluation tool for temporal processing in subjects with sensorineural hearing loss (SNHL). However, the results from other reports are varied making it difficult to clearly define the impact of SNHL on the temporal processing ability of the auditory system. Specifically, we do not know if and how a high-frequency hearing loss impacts, presumably through off-channel interaction, the temporal processing in low-frequency channels where hearing sensitivity is virtually normal. In this experiment, gap-evoked responses in a low-frequency band (0.5-8 kHz) were recorded in the inferior colliculus (IC) and auditory cortex (AC) of guinea pigs through implanted electrodes, before and after a slopping high-frequency hearing loss, which was induced by over- stimulation using a 12-kHz-tone. The results showed that the gap thresholds in the low-frequency region increased gradually and became significantly higher 8 weeks after the induced high-frequency hearing loss. In addition, the response latency was slightly increased in the IC but this was not true for the AC. These results strongly indicate that a high-frequency hearing loss exerted an off-channel impact on temporal processing in the low-frequency region of the auditory system. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Yin, Shan-Kai; Feng, Yan-Mei; Chen, Zheng-Nong; Wang, Jian] Shanghai Jiao Tong Univ, Otorhinolaryngol Inst, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.
[Wang, Jian] Dalhousie Univ, Sch Human Commun Disorder, Halifax, NS B3H 1R2, Canada.
RP Wang, J (reprint author), Shanghai Jiao Tong Univ, Otorhinolaryngol Inst, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.
EM jian.wang@dal.ca
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NR 85
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2008
VL 239
IS 1-2
BP 126
EP 140
DI 10.1016/j.heares.2008.02.002
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 307KB
UT WOS:000256316700012
PM 18348901
ER
PT J
AU Manley, GA
Koppl, C
AF Manley, Geoffrey A.
Koeppl, Christine
TI What have lizard ears taught us about auditory physiology?
SO HEARING RESEARCH
LA English
DT Article
DE lizard; hearing; evolution of hearing; otoacoustic emission; tuning;
cochlear prosthesis
ID SPONTANEOUS OTOACOUSTIC EMISSIONS; HAIR-CELLS; ALLIGATOR LIZARD; BOBTAIL
LIZARD; TONOTOPIC ORGANIZATION; BASILAR PAPILLA; GEKKO-GECKO; TOKAY
GECKO; FREQUENCY-SELECTIVITY; COCHLEAR AMPLIFIER
AB The structure of the basilar papilla of the inner ear of lizards is the most diverse among all vertebrates. Research on a variety of lizard ears, animals that are remarkably robust under laboratory conditions, has provided the field of auditory research with valuable information, particularly on the minimum structural requirements for sensitive, selective hearing and on the importance of the tectorial membrane and active processes in this regard. Despite the absence of a tuned basilar membrane, lizard ears produce highly frequency selective hearing through micromechanical tuning of small, resonant hair-cell-tectorial units or of free-standing hair bundles. These units are driven by an active process that also underlies spontaneous and other otoacoustic emissions. Lizard ears provided the first in vivo evidence that the active process is calcium-sensitive and ties within the stereovillar bundles of the hair cells. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Manley, Geoffrey A.] Tech Univ Munich, Lehrstuhl Zool, D-85747 Garching, Germany.
[Koeppl, Christine] Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia.
RP Manley, GA (reprint author), Tech Univ Munich, Lehrstuhl Zool, Lichtenbergstr 4, D-85747 Garching, Germany.
EM geoffrey.manley@wzw.tum.de
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NR 50
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 3
EP 11
DI 10.1016/j.heares.2007.09.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400002
PM 17983712
ER
PT J
AU Brugge, JF
Volkov, IO
Oya, H
Kawasaki, H
Reale, RA
Fenoy, A
Steinschneider, M
Howard, MA
AF Brugge, John F.
Volkov, Igor O.
Oya, Hiroyuki
Kawasaki, Hiroto
Reale, Richard A.
Fenoy, Albert
Steinschneider, Mitchell
Howard, Matthew A., III
TI Functional localization of auditory cortical fields of human:
Click-train stimulation
SO HEARING RESEARCH
LA English
DT Article
DE human auditory cortex; Heschl's gyrus; auditory evoked potential
ID SUPERIOR TEMPORAL GYRUS; TIME PHONETIC PARAMETER; EVOKED-POTENTIALS;
HUMAN BRAIN; TONOTOPIC ORGANIZATION; EEG RECORDINGS; HESCHLS GYRUS;
HUMAN CORTEX; AREAS; MONKEY
AB Averaged auditory evoked potentials (AEPs) to bilaterally presented 100 Hz click trains were recorded from multiple sites simultaneously within Heschl's gyrus (HG) and on the posterolateral surface of the superior temporal gyrus (STG) in epilepsy-surgery patients. Three auditory fields were identified based on AEP waveforms and their distribution. Primary (core) auditory cortex was localized to posteromedial HG. Here the AEP was characterized by a robust polyphasic low-frequency field potential having a short onset latency and on which was superimposed a smaller frequency-following response to the click train. Core AEPs exhibited the lowest response threshold and highest response amplitude at one HG site with threshold rising and amplitude declining systematically on either side of it. The AEPs recorded anterolateral to the core, if present, were typically of low amplitude, with little or no evidence of short-latency waves or the frequency-following response that characterized core AEPs. We suggest that this area is part of a lateral auditory belt system. Robust AEPs, with waveforms demonstrably different from those of the core or lateral belt, were localized to the posterolateral surface of the STG and conform to previously described field PLST. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Brugge, John F.; Reale, Richard A.] Univ Wisconsin, Dept Psychol, Madison, WI 53705 USA.
[Brugge, John F.; Volkov, Igor O.; Oya, Hiroyuki; Kawasaki, Hiroto; Reale, Richard A.; Fenoy, Albert; Howard, Matthew A., III] Univ Iowa, Coll Med, Dept Neurosurg, Iowa City, IA 52242 USA.
[Brugge, John F.] Univ Wisconsin, Dept Physiol, Madison, WI 53705 USA.
[Steinschneider, Mitchell] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA.
[Steinschneider, Mitchell] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA.
RP Brugge, JF (reprint author), Univ Wisconsin, Dept Psychol, Brogden Hall,1210 W Johnson St, Madison, WI 53705 USA.
EM Brugge@physiology.wisc.edu
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NR 55
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 12
EP 24
DI 10.1016/j.heares.2007.11.012
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400003
PM 18207680
ER
PT J
AU Heil, P
Neubauer, H
Brown, M
Irvine, DRF
AF Heil, Peter
Neubauer, Heinrich
Brown, Mel
Irvine, Dexter R. F.
TI Towards a unifying basis of auditory thresholds: Distributions of the
first-spike latencies of auditory-nerve fibers
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; spike timing; ribbon synapse; hair cell; Poisson
process; variability; latency; distribution; absolute threshold;
rate-level function
ID TEMPORAL INTEGRATION; HEARING-LOSS; GUINEA-PIG; ABSOLUTE THRESHOLD;
LEVEL FUNCTIONS; COMPUTER-MODEL; HAIR-CELLS; CAT; RESPONSES; DEPENDENCE
AB Detecting sounds in quiet is the simplest task performed by the auditory system, but the neural mechanisms underlying perceptual detection thresholds for sounds in quiet are still not understood. Heil and Neubauer [Heil, P., Neubauer, H., 2003. A unifying basis of auditory thresholds based on temporal summation. Proc. Natl. Acad. Sci. USA 100, 6151-6156] have provided evidence for a simple probabilistic model according to which the stimulus, at any point in time, has a certain probability of exceeding threshold and being detected. Consequently, as stimulus duration increases, the cumulative probability of detection events increases, performance improves, and threshold amplitude decreases. The origin of these processes was traced to the first synapse in the auditory system, between the inner hair cell and the afferent auditory-nerve fiber (ANF). Here we provide further support for this probabilistic "continuous-look" model. It is derived from analyses of the distributions of the latencies of the first spikes of cat ANFs with very low spontaneous discharge rates to tones of different amplitudes. The first spikes in these fibers can be considered detection events. We show that, as predicted, the distributions can be explained by the joint probability of the occurrence of three independent sub-events, where the probability of each of those occurring is proportional to the low-pass filtered stimulus amplitude. The "temporal integration" functions of individual ANFs, derived from their first-spike latencies, are remarkably similar in shape to "temporal integration" functions, which relate threshold sound pressure level at the perceptual level to stimulus duration. This further supports a close link between the mechanisms determining the timing of the first (and other) evoked spikes at the level of the auditory nerve and detection thresholds at the perceptual level. The possible origin and some functional consequences of the expansive power-law non-linearity are discussed. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Heil, Peter; Neubauer, Heinrich] Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany.
[Brown, Mel; Irvine, Dexter R. F.] Monash Univ, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia.
RP Heil, P (reprint author), Leibniz Inst Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany.
EM peter.heil@ifn-magdeburg.de; Heinrich.neubauer@ifn-magdeburg.de;
melbrown40@hotmail.com; Dexter.Irvine@med.monash.edu.au
RI Irvine, Dexter/F-7474-2011
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NR 61
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 25
EP 38
DI 10.1016/j.heares.2007.09.014
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400004
PM 18077116
ER
PT J
AU Sinex, DG
AF Sinex, Donal G.
TI Responses of cochlear nucleus neurons to harmonic and mistuned complex
tones
SO HEARING RESEARCH
LA English
DT Article
DE cochlear nucleus; chinchilla; complex sounds; spectral segregation;
auditory scene analysis
ID AUDITORY-NERVE FIBERS; CONCURRENT VOWEL IDENTIFICATION; FUNDAMENTAL
FREQUENCIES; PERCEPTUAL SEGREGATION; INFERIOR COLLICULUS; DISCHARGE
PATTERNS; PITCH; REPRESENTATION; COMPONENTS; SOUNDS
AB Preliminary measurements of the representation in the cochlear nucleus (CN) of harmonic tones, harmonic tones with mistuned components, and double harmonic tones are reported. These data indicate that, unlike auditory nerve fibers and IC neurons, neurons in the CN may exhibit one of several qualitatively different response patterns when stimulated with mistuned tones. Primary-like neurons synchronized their discharges to 2-3 individual stimulus components, much like auditory nerve fibers do. Chopper neurons tended to respond with the periodicity of envelopes produced by interactions between adjacent stimulus components but exhibited little or no response synchronized to individual stimulus components. A small proportion of CN neurons exhibited complex slowly-modulated discharge patterns similar to those that are commonly observed in the inferior colliculus (IC). The patterns obtained from CN neurons with different pure tone discharge patterns were generally consistent with expectations based on previous studies with other stimuli. The measurements provided additional insight into the hierarchical processing stages that result in the highly patterned responses of IC neurons to harmonic and mistuned tones. (C) 2007 Elsevier B.V. All rights reserved.
C1 Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
RP Sinex, DG (reprint author), Utah State Univ, Dept Psychol, 2810 Old Main Hill, Logan, UT 84322 USA.
EM don.sinex@usu.edu
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NR 43
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 39
EP 48
DI 10.1016/j.heares.2007.11.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400005
PM 18078726
ER
PT J
AU Joris, PX
Michelet, P
Franken, TP
Mc Laughlin, M
AF Joris, Philip X.
Michelet, Pascal
Franken, Tom P.
Mc Laughlin, Myles
TI Variations on a Dexterous theme: Peripheral time-intensity trading
SO HEARING RESEARCH
LA English
DT Article
DE time-intensity trading; phase-locking; temporal; correlogram;
fine-structure; binaural
ID LATERAL SUPERIOR OLIVE; AUDITORY-NERVE FIBERS; LOW-FREQUENCY NEURONS;
COCHLEAR NUCLEAR COMPLEX; INTERAURAL TIME; INFERIOR COLLICULUS; BINAURAL
INTERACTION; PHASE-LOCKING; LEVEL DISCRIMINATION; SOUND LOCALIZATION
AB Sound pressure level changes can affect the timing of spiketrains. Timing of spiketrains is critical for sensitivity to interaural timing differences (ITDs). Interaural level differences (ILDs) can therefore affect the ITD cue. It has been hypothesized that ILDs may be coded indirectly through a peripheral conversion of level to time (but it should be cautioned that the changes in phase with SPL in low-CF AN fibers of the cat are more complicated) (Jeffress, L.A., 1948. A place theory of sound localization. J. Comp. Physiol. Psychol. 41, 35-39). We tested this conversion by recording from auditory nerve fibers to broadband noise at different SPLs. For each fiber, correlograms were constructed to compare timing to tine-structure across SPLs. We find generally a decrease in the time delay between spikes and the stimulus with increasing SPL. However, the magnitudes of the shift in time are surprisingly small, and dependent on characteristic frequency (CF): the largest shifts are approximately 10 mu s/dB and occur at the lowest Us. Nevertheless, the effects of level on spike timing are systematic and of a magnitude to which the binaural system is sensitive. Thus, even though the results indicate that ILD is not traded for ITD in a simple way, the possibility that low-frequency ILDs affect the binaural percept via a peripheral level-to-time conversion cannot be excluded. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Joris, Philip X.; Michelet, Pascal; Franken, Tom P.; Mc Laughlin, Myles] Katholieke Univ Leuven, Sch Med, Lab Auditory Neurophysiol, B-3000 Louvain, Belgium.
RP Joris, PX (reprint author), Katholieke Univ Leuven, Sch Med, Lab Auditory Neurophysiol, Campus Gasthuisberg O&N2,Herestr 49,Bus 1021, B-3000 Louvain, Belgium.
EM philip.joris@med.kuleuven.be; pascal.michelet@student.kuleuven.be;
tom.franken@student.kuleuven.be; myles.mclaughlin@med.kuleuven.be
RI Joris, Philip/D-9608-2011
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NR 65
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 49
EP 57
DI 10.1016/j.heares.2007.11.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400006
PM 18187277
ER
PT J
AU Park, TJ
Brand, A
Koch, U
Ikebuchi, M
Grothe, B
AF Park, Thomas J.
Brand, Antje
Koch, Ursula
Ikebuchi, Maki
Grothe, Benedikt
TI Dynamic changes in level influence spatial coding in the lateral
superior olive
SO HEARING RESEARCH
LA English
DT Article
DE binaural; sound localization; interaural level difference
ID INFERIOR COLLICULUS NEURONS; BINAURAL RESPONSE PROPERTIES; INTERAURAL
PHASE DISPARITY; PRIMARY AUDITORY-CORTEX; DORSAL NUCLEUS; COCHLEAR
NUCLEUS; GABAERGIC INHIBITION; SOUND LOCALIZATION; RECEPTIVE-FIELDS; CAT
AB It is well established that the responses of binaural auditory neurons can adapt and change dramatically depending on the nature of a preceding sound. Examples of how the effects of ensuing stimuli play a functional role in auditory processing include motion sensitivity and precedence-like effects. To date, these types of effects have been documented at the level of the midbrain and above. Little is known about sensitivity to ensuing stimuli below in the superior olivary nuclei where binaural response properties are first established. Here we report on single cell responses in the gerbil lateral superior olive, the initial site where sensitivity to interaural level differences is established. In contrast to our expectations we found a robust sensitivity to ensuing stimuli. The majority of the cells we tested (86%), showed substantial suppression and/or enhancement to a designated target stimulus, depending on the nature of a preceding stimulus. Hence, sensitivity to ensuing stimuli is already established at the first synaptic station of binaural processing. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Park, Thomas J.] Univ Illinois, Dept Biol Sci, Lab Integrat Neurosci, Chicago, IL 60607 USA.
[Park, Thomas J.; Brand, Antje; Koch, Ursula; Ikebuchi, Maki; Grothe, Benedikt] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany.
[Koch, Ursula; Grothe, Benedikt] Univ Munich, Div Neurobiol, Dept Biol 2, D-82152 Martinsried, Germany.
[Ikebuchi, Maki] Univ Tokyo, Dept Cognit & Behav Sci, Tokyo 1538902, Japan.
RP Park, TJ (reprint author), Univ Illinois, Dept Biol Sci, Lab Integrat Neurosci, Chicago, IL 60607 USA.
EM Tpark@uic.edu
RI Grothe, Benedikt/A-7877-2010
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NR 54
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 58
EP 67
DI 10.1016/j.heares.2007.10.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400007
PM 18162347
ER
PT J
AU Kitzes, L
AF Kitzes, Leonard
TI Binaural interactions shape binaural response structures and frequency
response functions in primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE frequency response function; binaural interactions; cortex; azimuth;
localization
ID SOUND PRESSURE LEVEL; SPECTROTEMPORAL RECEPTIVE-FIELDS; INTERAURAL
INTENSITY DIFFERENCES; UNIT AZIMUTH SENSITIVITY; SPATIAL SENSITIVITY;
INFERIOR COLLICULUS; CAT; NEURONS; REPRESENTATION; AI
AB The overall purpose of this study is to examine the behavior of primary auditory cortex (AI) units in the three-dimensional stimulus space that resembles normal listening conditions, viz., level at the two ears and frequency. A binaural-level response area (LRA) is the response to a matrix of contralateral and ipsilateral stimuli presented at a single frequency. LRAs have been examined in the inferior colliculus and AI and found to be highly organized response patterns that are shaped by binaural interactions. The aggregate of LRAs across frequency is the binaural response structure (BRS), a new concept that captures unit behavior in this three-dimensional stimulus space. Since binaural interactions contribute greatly to configuring component LRAs, it is clear that binaural interactions help shape the aggregate BRS. The BRS contains the data required to generate binaural frequency response functions. The frequency range and magnitude of these functions depend on the level of the stimulus at each ear and the configuration of the BRS. Changing either level can greatly alter the binaural frequency response function. Thus, in addition to their classic role in localization, binaural interactions play a fundamentally important role in determining the frequency domain of units in AI. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA.
RP Kitzes, L (reprint author), Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA.
EM lmkitzes@uci.edu
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NR 43
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 68
EP 76
DI 10.1016/j.heares.2008.01.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400008
PM 18295994
ER
PT J
AU May, BJ
Anderson, M
Roos, M
AF May, Bradford J.
Anderson, Michael
Roos, Matthew
TI The role of broadband inhibition in the rate representation of spectral
cues for sound localization in the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
DE head-related transfer function; spatial tuning; spectral integration;
level tolerance; monaural hearing
ID DORSAL COCHLEAR NUCLEUS; AUDITORY-NERVE FIBERS; LATERAL SUPERIOR OLIVE;
TEMPORAL RECEPTIVE-FIELD; FREQUENCY-RESPONSE AREAS; SINGLE-UNIT
RESPONSES; STEADY-STATE VOWELS; DISCHARGE RATE; DECEREBRATE CATS;
BASILAR-MEMBRANE
AB Previous investigations have shown that a subset of inferior colliculus neurons, which have been designated type 0 units, respond selectively to isolated features of the cat's head-related transfer functions (HRTFs: the directional transformation of a free-field sound as it propagates from the head to the eardrum). Based on those results, it was hypothesized that type 0 units would show enhanced spatial tuning in a virtual sound field that conveyed the full complement of HRTF-based localization cues. As anticipated, a number of neurons produced representations of virtual sound source locations that were spatially tuned, level tolerant, and effective under monaural conditions. Preferred locations were associated with spectral cues that complemented the highly individualized broadband inhibitory patterns of tuned neurons. That is, higher response magnitudes were achieved when spectral peaks coincided with excitatory influences at best frequency (BF: the most sensitive frequency) and spectral notches fell within flanking inhibitory regions. The directionally dependent modulation of narrowband ON-BF excitation by broadband OFF-BF inhibition was not a unique property of type 0 units. (C) 2008 Elsevier B.V. All rights reserved.
C1 [May, Bradford J.] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Ctr Hearing & Balance, Baltimore, MD 21205 USA.
[Anderson, Michael] Johns Hopkins Univ, Dept Biomed Engn, Ctr Hearing & Balance, Baltimore, MD 21205 USA.
[Roos, Matthew] Johns Hopkins Univ, Dept Neurosci, Ctr Hearing & Balance, Baltimore, MD 21205 USA.
RP May, BJ (reprint author), Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Ctr Hearing & Balance, Traylor Bldg,Room 521,720 Rutland Ave, Baltimore, MD 21205 USA.
EM bmay@jhu.edu
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NR 98
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 77
EP 93
DI 10.1016/j.heares.2008.01.008
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400009
PM 18295420
ER
PT J
AU Moore, JM
Tollin, DJ
Yin, TCT
AF Moore, Jordan M.
Tollin, Daniel J.
Yin, Tom C. T.
TI Can measures of sound localization acuity be related to the precision of
absolute location estimates?
SO HEARING RESEARCH
LA English
DT Article
DE minimum audible angle (MAA); auditory space map; cat
ID MINIMUM AUDIBLE ANGLE; AUDITORY SPATIAL ACUITY; DORSAL COCHLEAR NUCLEUS;
CAT SUPERIOR COLLICULUS; BARN OWLS; RECEPTIVE-FIELDS; VERTICAL PLANES;
HUMAN LISTENERS; SPECTRAL CUES; EYE POSITION
AB Studies of sound localization use relative or absolute psychoacoustic paradigms. Relative tasks assess acuity by determining the smallest angle separating two sources that subjects can discriminate, the minimum audible angle (MAA), whereas absolute tasks measure subjects' abilities to indicate sound location. It is unclear whether or how measures from the two tasks are related, though the belief that the MAA is specifically related to the precision of absolute localization is common. The present study aimed to investigate the basis of this relationship by comparing the precision of absolute location estimates with a measure of spatial acuity computed from the same data. Three cats were trained to indicate apparent sound source locations that varied in azimuth and elevation via orienting gaze shifts (combined eye and head movements). The precision of these absolute responses, as measured by their standard deviation, was compared with acuity thresholds derived from receiver operating characteristic (ROC) analyses of the cumulative distributions. Surprisingly, the acuity measures were occasionally very poor indicators of absolute localization precision. Incongruent results were attributed to errors in mean accuracy, which are disregarded in analyses of traditional relative tasks. Discussion focuses on the potential for internal biases to affect measures of localization acuity. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Moore, Jordan M.; Tollin, Daniel J.; Yin, Tom C. T.] Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
RP Moore, JM (reprint author), Cornell Univ, Dept Neurobiol & Behav, W345 Mudd Hall,Tower Rd, Ithaca, NY 14853 USA.
EM jmm256@cornell.edu; Daniel.Tollin@UCHSC.edu; yin@physiology.wisc.edu
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NR 59
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 94
EP 109
DI 10.1016/j.heares.2007.11.006
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400010
PM 18178351
ER
PT J
AU Martin, RL
McAnally, KI
AF Martin, Russell L.
McAnally, Ken I.
TI Spectral integration time of the auditory localisation system
SO HEARING RESEARCH
LA English
DT Article
DE sound localisation; time window; temporal window
ID SOUND LOCALIZATION; TEMPORAL WINDOW; THRESHOLDS; AUDIO; PLANE; SHAPE;
AGE
AB For the elevation and front-versus-back hemifield of a sound source to be accurately determined, the sound must contain a broad range of frequencies.
Experiment 1 of this study examined the spectral integration time of the auditory localisation system by measuring the accuracy with which frequency-modulated (FM) tones of modulation periods ranging from 0.5 to 200 ms can be localised. For each of the four participants, judgements of sound-source elevation and front-back hemifield were most accurate for a modulation period of 5 ms. Accuracy levels for the 5 ms modulation period approached those for a pink-noise stimulus. This suggests that the spectral integration time of the auditory localisation system is around 5 ms.
Supporting evidence for this conclusion was sought in experiment 2, in which two participants localised noise stimuli that had magnitude spectra identical to those of 5 ms equivalent-rectangular-duration samples of the FM tones from experiment 1. For both participants, functions relating localisation error measures (i.e., elevation error and frequency of front-back confusion) to modulation period for spectrally matched noises were similar to those for FM tones. Crown Copyright (C) 2007 Published by Elsevier B.V. All rights reserved.
C1 [Martin, Russell L.; McAnally, Ken I.] Def Sci & Technol Org, Air Operat Div, Melbourne, Vic 3001, Australia.
RP Martin, RL (reprint author), Def Sci & Technol Org, Air Operat Div, POB 4331, Melbourne, Vic 3001, Australia.
EM russell.martin@dsto.defence.gov.au; ken.mcanally@dsto.defence.gov.au
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NR 19
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 118
EP 123
DI 10.1016/j.heares.2007.08.006
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400012
PM 17996410
ER
PT J
AU Phillips, DP
AF Phillips, Dennis P.
TI A perceptual architecture for sound lateralization in man
SO HEARING RESEARCH
LA English
DT Article
DE sound lateralization; sound localization; neural models; mammalian
hearing; psychophysics
ID PRIMARY AUDITORY-CORTEX; INTERAURAL TIME DIFFERENCES; SPATIAL
RECEPTIVE-FIELDS; SUPERIOR OLIVARY COMPLEX; LOW-FREQUENCY NEURONS; OWLS
BRAIN-STEM; INFERIOR COLLICULUS; DELAY-LINES; BINAURAL INTERACTIONS;
INTENSITY DIFFERENCES
AB There are two general neurophysiological models of sound lateralization mechanisms which may be active in man. Both of the models are derived from studies in animals (one in barn owls, and one in mammals), and both have displayed some weakness in generalizability. One model advocates a population of neurons narrowly tuned to different interaural disparity values across the behaviorally relevant range, so that the cue value, and therefore the source azimuth, is represented by which neurons of the array are activated by the stimulus. The second model posits the existence of only two neural channels, each broadly tuned to interaural cue values favoring one acoustic hemifield, so that, especially for sources near the midline, cue value and therefore source azimuth is encoded by the relative activation of the two neural populations. The present article reviews three recent psychophysical studies, each using selective adaptation paradigms to probe sound lateralization mechanisms based on interaural disparities in normal human listeners. These experiments provided evidence on the frequency-specificity of interaural disparity coding and revealed its sensitivity to recent stimulus history. The data from those studies, however, also help distinguish the two lateralization models, and favor a perceptual architecture for sound lateralization in man based on the activity of two, hemifield-tuned azimuthal channels. (C) 2007 Elsevier B.V. All rights reserved.
C1 Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
RP Phillips, DP (reprint author), Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
EM dennis.phillips@dal.ca
RI Phillips, Dennis/A-6496-2011
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NR 65
TC 18
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 124
EP 132
DI 10.1016/j.heares.2007.09.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400013
PM 17980984
ER
PT J
AU Wester, K
AF Wester, Knut
TI Auditory based neuropsychology in neurosurgery
SO HEARING RESEARCH
LA English
DT Article
DE arachnoid cyst; auditory system; cognition; dichotic listening;
Parkinson's disease; thalamus
ID INTRACRANIAL ARACHNOID CYSTS; DEEP BRAIN-STIMULATION; DECOMPRESSION;
LATERALITY; HEMORRHAGE; DISORDERS; ASYMMETRY; ATTENTION; LANGUAGE;
THALAMUS
AB In this article, an account is given on the author's experience with auditory based neuropsychology in a clinical, neurosurgical setting. The patients that were included in the studies are patients with traumatic or vascular brain lesions, patients undergoing brain surgery to alleviate symptoms of Parkinson's disease, or patients harbouring an intracranial arachnoid cyst affecting the temporal or the frontal lobe. The aims of these investigations were to collect information about the location of cognitive processes in the human brain, or to disclose dyscognition in patients with an arachnoid cyst. All the patients were tested with the DL technique. In addition, the cyst patients were subjected to a number of non-auditory, standard neuropsychological tests, such as Benton Visual Retention Test, Street Gestalt Test, Stroop Test and Trails Test A and B. The neuropsychological tests revealed that arachnoid cysts in general cause dyscognition that also includes auditory processes, and more importantly, that these cognition deficits normalise after surgical removal of the cyst. These observations constitute strong evidence in favour of surgical decompression. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Wester, Knut] Univ Bergen, Dept Surg Sci, Neurosurg Sect, N-5021 Bergen, Norway.
[Wester, Knut] Haukeland Hosp, Dept Neurosurg, N-5021 Bergen, Norway.
RP Wester, K (reprint author), Univ Bergen, Dept Surg Sci, Neurosurg Sect, N-5021 Bergen, Norway.
EM kgwe@helse-bergen.no
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NR 24
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 133
EP 138
DI 10.1016/j.heares.2007.09.012
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400014
PM 18024027
ER
PT J
AU Eramudugolla, R
McAnally, KI
Martin, RL
Irvine, DRF
Mattingley, JB
AF Eramudugolla, Ranmalee
McAnally, Ken I.
Martin, Russell L.
Irvine, Dexter R. F.
Mattingley, Jason B.
TI The role of spatial location in auditory search
SO HEARING RESEARCH
LA English
DT Article
DE auditory perception; change detection; head-related transfer function;
attention
ID COCKTAIL PARTY PHENOMENON; SPEECH-INTELLIGIBILITY; FREQUENCY; ATTENTION;
AUDIO; CUES; ADVANTAGE; SOUNDS; TIME; TASK
AB The majority of research findings to date indicate that spatial cues play a minor role in enhancing listeners' ability to parse and detect a sound of interest when it is presented in a complex auditory scene comprising multiple simultaneous sounds. Frequency and temporal differences between sound streams provide more reliable cues for scene analysis as well as for directing attention to relevant auditory 'objects' in complex displays. The present study used naturalistic sounds with varying spectro-temporal profiles to examine whether spatial separation of sound sources can enhance target detection in an auditory search paradigm. The arrays of sounds were presented in virtual auditory space over headphones. The results of Experiment I suggest that target detection is enhanced when sound sources are spatially separated relative to when they are presented at the same location. Experiment 2 demonstrated that this effect is most prominent within the first 250 ms of exposure to the array of sounds. These findings suggest that spatial cues may be effective for enhancing early processes such as stream segregation, rather than simply directing attention to objects that have already been segmented. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Eramudugolla, Ranmalee; Mattingley, Jason B.] Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
[Eramudugolla, Ranmalee; Mattingley, Jason B.] Univ Queensland, Queensland Brian Inst, Cognit Neurosci Lab, Brisbane, Qld 4072, Australia.
[McAnally, Ken I.; Martin, Russell L.] Def Sci & Technol Org, Air Operat Div, Port Melbourne, Vic 3207, Australia.
[Irvine, Dexter R. F.] Monash Univ, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia.
RP Eramudugolla, R (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
EM ranmalee@psy.uq.edu.au
RI Irvine, Dexter/F-7474-2011; Mattingley, Jason/J-1537-2014
OI Mattingley, Jason/0000-0003-0929-9216
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NR 39
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 139
EP 146
DI 10.1016/j.heares.2007.10.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400015
PM 18082346
ER
PT J
AU Moore, DR
Ferguson, MA
Halliday, LF
Riley, A
AF Moore, David R.
Ferguson, Melanie A.
Halliday, Lorna F.
Riley, Alison
TI Frequency discrimination in children: Perception, learning and attention
SO HEARING RESEARCH
LA English
DT Article
DE auditory processing; vision; development; training; mainstream school
ID PSYCHOMETRIC FUNCTIONS; MASKING; SPEECH
AB It is generally believed that both sensory immaturity and inattention contribute to the poor listening of some children. However, the relative contribution of each factor, within and between individuals, and the nature of the inattention are poorly understood. In three experiments we examined the threshold and response variability of 6-11 y.o. children on pure tone frequency discrimination (1713) tasks. We first confirmed that younger children had both higher thresholds and greater within- and between-listener variability than older children and adults. Higher thresholds were mostly attributed to high response variability due to poor sustained attention. We next compared performance on the auditory FD task with that on visual spatial FD. No correlation was found between the thresholds or variability of individuals on the two tasks, suggesting involvement of modality-specific attention. Finally, we found lower thresholds for 8-9 y.o. children performing auditory FD training in a classroom than in the laboratory, possibly due to training session length or to a more familiar, motivating and focussed training environment. The adult-like performance of many younger children at times during their testing or training, together with the high response variability of immature performers, suggested that most elevated FD thresholds in children are due to inattention. (C) 2007 Published by Elsevier B.V.
C1 [Moore, David R.; Ferguson, Melanie A.; Halliday, Lorna F.; Riley, Alison] MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Moore, DR (reprint author), MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
EM davem@ihr.mrc.ac.uk
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NR 19
TC 35
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 147
EP 154
DI 10.1016/j.heares.2007.11.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400016
PM 18222053
ER
PT J
AU Cainer, KE
James, C
Rajan, R
AF Cainer, Kathryn E.
James, C.
Rajan, R.
TI Learning speech-in-noise discrimination in adult humans
SO HEARING RESEARCH
LA English
DT Article
DE speech; speech-in-noise discrimination; noise type; learning
ID GAP DURATION DISCRIMINATION; AGE-RELATED-CHANGES; HEARING-LOSS; ELDERLY
LISTENERS; WORD RECOGNITION; TIME-COURSE; RECEPTION THRESHOLD;
COGNITIVE-FACTORS; OLDER ADULTS; INTELLIGIBILITY
AB This manuscript reports the results of two studies on development of a test bank of sentences for use in study of learning of speeeb-in-noise (SIN) discrimination. Sentences were derived from the sentence lists of Bench et al., 1979 [Bench, J., Kowal, angstrom., Bamford, J., 1979. The BKB (Bamford-Kowal-Bench) sentence lists for partially-hearing children. Brit. J. Audiol. 13, 108-112]. In the first study these sentences were grouped into three different lists (each of 40 sentences) based on their previously-determined speech reception thresholds (SRTs), and used to study SIN discrimination. In each test with 40 sentences in the SIN task, within-session performance asymptoted rapidly, independent of masker type, sex of subjects, and type of sentence. Then, in a second study, six lists of sentences were created to study learning of SIN discrimination, in a new group of subjects. It was found that across-session learning was rapid regardless of noise type, and the same general pattern of learning occurred regardless of noise type; however the amount of learning differed, with a slightly greater amount of learning occurring in the condition with the more difficult noise masker. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Cainer, Kathryn E.; James, C.; Rajan, R.] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia.
RP Rajan, R (reprint author), Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia.
EM ramesh.rajan@med.monash.edu.au
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NR 70
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2008
VL 238
IS 1-2
BP 155
EP 164
DI 10.1016/j.heares.2007.10.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 293HD
UT WOS:000255325400017
PM 18024026
ER
PT J
AU Hutson, KA
Durham, D
Imig, T
Tucci, DL
AF Hutson, K. A.
Durham, D.
Imig, T.
Tucci, D. L.
TI Consequences of unilateral hearing loss: Cortical adjustment to
unilateral deprivation
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; medial geniculate; inferior colliculus; 2-deoxyglucose;
conductive hearing loss; cochlear ablation; gerbil
ID PRIMARY AUDITORY-CORTEX; GERBIL MERIONES-UNGUICULATUS; MEDIAL
GENICULATE-BODY; FREQUENCY-MODULATED TONES; VENTRAL COCHLEAR NUCLEUS;
MIDDLE-EAR DESTRUCTION; INFERIOR COLLICULUS; MONGOLIAN GERBIL;
FUNCTIONAL-ORGANIZATION; RESPONSE PROPERTIES
AB The effect of unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied in postnatal day 21 gerbils. Three weeks following a unilateral conductive hearing loss (CHL) or cochlear ablation (CA), animals were injected with 2-DG and exposed to an alternating auditory stimulus (I and 2 kHz tones). Uptake of 2-DG was measured in the inferior colliculus (IC), medial geniculate (MG), and auditory cortex (fields AI and AAF) of both sides of the brain in experimental animals and in anesthesia-only sham animals (SH). Significant differences in uptake, compared to SH, were found in the IC contralateral to the manipulated ear (CHL or CA) and in AAF contralateral to the CHL ear. We hypothesize that these findings may result from loss of functional inhibition in the IC contralateral to CA, but not CHL. Altered states of inhibition at the IC may affect activity in pathways ascending to auditory cortex, and ultimately activity in auditory cortex itself. Altered levels of activity in auditory cortex may explain some auditory processing deficits experienced by individuals with CHL. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Hutson, K. A.; Tucci, D. L.] Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Durham, NC 27710 USA.
[Durham, D.] Univ Kansas, Med Ctr, Dept Otolaryngol, Kansas City, KS 66160 USA.
[Imig, T.] Univ Kansas, Med Ctr, Dept Physiol, Kansas City, KS 66160 USA.
RP Tucci, DL (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Box 3805, Durham, NC 27710 USA.
EM tucci001@mc.duke.edu
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NR 90
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 19
EP 31
DI 10.1016/j.heares.2007.12.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000002
PM 18261867
ER
PT J
AU Yin, SK
Chen, ZN
Yu, DZ
Feng, YM
Wang, J
AF Yin, Shankai
Chen, Zhengnong
Yu, Dongzhen
Feng, Yanmel
Wang, Jian
TI Local inhibition shapes duration tuning in the inferior colliculus of
guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE gamma-aminobutyric acid; glycine; auditory; duration coding; inferior
colliculus; guinea pigs
ID BIG BROWN BAT; INTERAURAL TIME DIFFERENCES; SOUND-DURATION;
EPTESICUS-FUSCUS; RESPONSE PROPERTIES; AUDITORY-CORTEX; BRAIN-STEM;
GLYCINERGIC INHIBITION; TEMPORAL INTEGRATION; IDENTIFIED NEURONS
AB Neural tuning to sound durations is a useful filter for the identification of a variety of sounds. Previous studies have shown that the interaction between excitatory and inhibitory inputs plays a role in duration selectivity in echolocating bats. However, this has not been investigated in non-echolocating mammals. In the inferior colliculus (IC) of these mammals, it is recognized that the excitatory responses to sounds are mediated through AMPA and NMDA receptors while the inhibitory input is mediated through gamma-aminobutyric acid (GABA) and glycine receptors. The present study explores the potential interplay between inhibitory and excitatory inputs and its role in the duration selectivity of IC neurons in guinea pigs. It was found that the application of bicuculline (BIC, a GABA(A) blocker) and/or strychnine (STRY, a glycine blocker) eliminated or reduced duration tuning in most units that were duration tuned (32 out of 39 for BIC, 50 out of 64 for STRY, respectively). The inhibitory input (either by GABA or by glycine) appeared to have a stronger regulating effect on the early excitation mediated by AMPA than on later excitation by NMDA. This is more distinguishable in neurons that show duration selectivity. In conclusion, the inhibitory effect on the early responses appears to be the main contributor for the duration selectivity of the IC in guinea pigs; potential mechanisms for this duration selectivity are also discussed. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Yin, Shankai; Chen, Zhengnong; Yu, Dongzhen; Feng, Yanmel; Wang, Jian] Shanghai Jiao Tong Univ, Otolaryngol Inst, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.
[Wang, Jian] Dalhousie Univ, Sch Human Commun Disorders, Halifax, NS, Canada.
RP Wang, J (reprint author), Shanghai Jiao Tong Univ, Otolaryngol Inst, Affiliated Peoples Hosp 6, 600 Yishan Rd,7th Bldg Rm220, Shanghai 200233, Peoples R China.
EM jian.wang@dal.ca
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NR 73
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 32
EP 48
DI 10.1016/j.heares.2007.12.008
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000003
PM 18255245
ER
PT J
AU Jonsson, R
Hanekom, T
Hanekom, JJ
AF Joensson, R.
Hanekom, T.
Hanekom, J. J.
TI Initial results from a model of ephaptic excitation in the electrically
excited peripheral auditory nervous system
SO HEARING RESEARCH
LA English
DT Article
DE Hodgkin-Huxley model; ephaptic excitation; cochlear implant; spread of
neural excitation
ID SPIRAL GANGLION; INFERIOR COLLICULUS; STIMULATION; CELLS; CAT
AB This article reports on a study performed to investigate the occurrence and effect of ephaptic excitation in electrical stimulation of the auditory system. The objective of the study was to quantify the influence of ephaptic excitation on nerve stimulation and determine whether it is a necessary factor in neuromodeling. It was shown with a simple model that ephaptic excitation could be important at stimulus intensities close to threshold. The results show that the contribution of ephaptic excitation is significant up to at least 6-7 dB above threshold. Cochlear implant patients normally have a small dynamic range (average of 7 dB), indicating that the ephaptic effect might be important in models of the implanted cochlea. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Joensson, R.; Hanekom, T.; Hanekom, J. J.] Univ Pretoria, Elect Elect & Computer Engn Bioengn Grp, ZA-0002 Pretoria, Gauteng, South Africa.
RP Hanekom, T (reprint author), Univ Pretoria, Elect Elect & Computer Engn Bioengn Grp, Lynnwood Rd, ZA-0002 Pretoria, Gauteng, South Africa.
EM tania.hanekom@up.ac.za
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NR 18
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 49
EP 56
DI 10.1016/j.heares.2007.12.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000004
PM 18255244
ER
PT J
AU Williamson, RE
Darrow, KN
Giersch, ABS
Resendes, BL
Huang, M
Conrad, GW
Chen, ZY
Liberman, MC
Morton, CC
Tasheva, ES
AF Williamson, Robin E.
Darrow, Keith N.
Giersch, Anne B. S.
Resendes, Barbara L.
Huang, Mingqian
Conrad, Gary W.
Chen, Zheng-Yi
Liberman, M. Charles
Morton, Cynthia C.
Tasheva, Elena S.
TI Expression studies of osteoglycin/mimecan (OGN) in the cochlea and
auditory phenotype of Ogn-deficient mice
SO HEARING RESEARCH
LA English
DT Article
DE mimecan/osteoglycin; proteoglycan; hearing loss
ID RECESSIVE ALPORT SYNDROME; PROGRESSIVE HEARING-LOSS; COL4A5 COLLAGEN
GENE; AUTOSOMAL-DOMINANT; INNER-EAR; STICKLER-SYNDROME; OSTEOGENESIS
IMPERFECTA; NONSYNDROMIC DEAFNESS; MENIERES-DISEASE; CDNA LIBRARY
AB Genes involved in the hearing process have been identified through both positional cloning efforts following genetic linkage studies of families with heritable deafness and by candidate gene approaches based on known functional properties or inner ear expression. The latter method of gene discovery may employ a tissue- or organ-specific approach. Through characterization of a human fetal cochlear cDNA library, we have identified transcripts that are preferentially and/or highly expressed in the cochlea. High expression in the cochlea may be suggestive of a fundamental role for a transcript in the auditory system. Herein we report the identification and characterization of a transcript from the cochlear cDNA library with abundant cochlear expression and unknown function that was subsequently determined to represent osteoglycin (OGN). Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Giersch, Anne B. S.; Resendes, Barbara L.; Morton, Cynthia C.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.
[Williamson, Robin E.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
[Darrow, Keith N.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
[Darrow, Keith N.] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA USA.
[Morton, Cynthia C.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA.
[Chen, Zheng-Yi] Massachusetts Gen Hosp, Ctr Nervous Syst Repair, Neurol Serv, Boston, MA 02114 USA.
[Conrad, Gary W.] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA.
[Tasheva, Elena S.] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA.
RP Morton, CC (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, NRB 160,77 Ave Louis Pasteur, Boston, MA 02115 USA.
EM cmorton@partners.org
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NR 46
TC 7
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 57
EP 65
DI 10.1016/j.heares.2007.12.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000005
PM 18243607
ER
PT J
AU Sun, XM
AF Sun, Xiao-Ming
TI Contralateral suppression of distortion product otoacoustic emissions
and the middle-ear muscle reflex in human ears
SO HEARING RESEARCH
LA English
DT Article
DE distortion product otoacoustic emission; DPOAE contralateral
suppression; medial olivocochlear bundle; middle-ear muscle; acoustic
reflex; contralateral acoustic stimulation
ID COCHLEAR MICROMECHANICAL PROPERTIES; ACOUSTIC-REFLEX; ENERGY
REFLECTANCE; SOUND STIMULATION; FREQUENCY; ADAPTATION; SYSTEM;
THRESHOLDS; 2F(1)-F(2); IMPEDANCE
AB Distortion product otoacoustic emissions (DPOAEs) were measured in the absence and presence of contralateral noise at five levels-below, equal to, and above the middle-car muscle (MEM) reflex threshold. The resultant changes in DPOAE level and phase were dependent on stimulus frequency and noise level. Both low-level noise, believed to elicit the medial olivocochlear (MOC) reflex, and high-level noise, thought to activate both MOC and MEM reflexes, significantly decreased the DPOAE level. However, the shift from sole MOC effect to mixed MOC and MEM effects was not as dramatic as we thought. While low-level noise resulted in a minimum DPOAE phase change, high-level noise caused a substantial phase lead for 1 and 2 kHz. With increasing frequency, phase lag became more notable. The present study suggests the following: (1) DPOAE contralateral suppression by low-level sound most likely does not involve the effect of the MEM reflex and signal crossover; and (2) combined analysis of DPOAE level and phase changes warrants further investigations to overcome the difficulty in separating the effects of MOC efferents and MEM contraction. The results also imply that OAE measurement has the potential for being used to investigate the effect of the MEM reflex on sound transmission. (C) 2007 Elsevier B.V. All rights reserved.
C1 Wichita State Univ, Dept Commun Sci & Disorders, Wichita, KS 67260 USA.
RP Sun, XM (reprint author), Wichita State Univ, Dept Commun Sci & Disorders, 1845 Fairmt St, Wichita, KS 67260 USA.
EM xiao-ming.sun@wichita.edu
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NR 43
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 66
EP 75
DI 10.1016/j.heares.2007.12.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000006
PM 18258398
ER
PT J
AU Marcon, S
Patuzzi, R
AF Marcon, Simon
Patuzzi, Robert
TI Changes in cochlear responses in guinea pig with changes in
perilymphatic K+. Part 1: Summating potentials, compound action
potentials and DPOAEs
SO HEARING RESEARCH
LA English
DT Article
DE potassium; compound action potential; summating potential; distortion
product; tinnitus; deafness
ID OUTER HAIR-CELLS; AUDITORY-NERVE FIBERS; POTASSIUM CONCENTRATION; VOLUME
REGULATION; CAT; ACETYLCHOLINE; MECHANISM; PERFUSION; RUBIDIUM
AB We have measured the effects of changing perilymphatic K+ by perfusing Scala tympani in guinea pigs with salt solutions high or low in K+, while monitoring the distortion product otoacoustic emissions (DPOAEs) in the ear canal (a measure of mechanical vibration of the organ of Corti), the summating potential (SP) evoked by high-frequency tone-bursts (taken to be a measure of pre-synaptic electrical activity of the inner hair cells) and the compound action potential (CAP) of the auditory nerve (taken to be a measure of post-synaptic neural activity). We have attempted to investigate the osmotic effects of our perfusates by comparison with simple hyperosmotic sucrose perfusates and iso-osmotic versions of perfusates, and for the effects of changes in other ions (e.g. Na+ and Cl-) by keeping these constant in some perfusates while elevating K+. We have found that changing the K+ concentration over the range 0-30 mM elevated the SP and CAP thresholds almost equally in normal animals, and not at all in animals devoid of outer hair cells (OHCs), showing that OHCs are sensitive to the perfusates we have used, but the inner hair cells (IHCs) and the type I afferent dendrites are not, presumably because IHCs are shielded from perilymph by supporting cells, and the membranes of the afferent dendrite membranes exposed directly to our perfusates are dominated by Cl- permeability, rather than by K+ permeability. This view is supported by experiments in which the perilymphatic Cl- concentration was reduced, producing a large elevation in CAP threshold, but a much smaller elevation of SP threshold, suggesting disruption of action potential initiation. The view that threshold elevations with changes in perilymphatic K+ are due almost solely to a disruption of OHC function and a consequent change in the mechanical sensitivity of the organ of Corti was supported by measurements of amplitude of the 2f(1)-f(2) distortion product otoacoustic emission. During elevations in K+, DPOAEs followed a similar time-course to that for SP and CAP, although the changes were less for DPOAEs. The lack of a 1:1 relationship between DPOAEs and SP and CAP is probably because the iso-input DPOAE measure used is a more complex indicator of mechanical sensitivity than the iso-output measure used by others. Taken together, these results suggest that changes in K+ in pathological conditions probably produce a hearing loss by disrupting IHCs rather than OHC or neurotics, and that OHC disruption in our experiments was due to a mixture of osmotic, K+ and possibly Cl- effects. (C) 2008 Elsevier B.V. All rights reserved.
C1 Univ Western Australia, Sch Biomed Biomol & Chem Sci, Nedlands, WA 6009, Australia.
RP Patuzzi, R (reprint author), Univ Western Australia, Sch Biomed Biomol & Chem Sci, 35 Stirling Highway, Nedlands, WA 6009, Australia.
EM rpatuzzi@cyllene.uwa.edu.au
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NR 36
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 76
EP 89
DI 10.1016/j.heares.2007.12.011
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000007
PM 18262371
ER
PT J
AU Megerian, CA
Semaan, MT
Aftab, S
Kisley, LB
Zheng, QY
Pawlowski, KS
Wright, CG
Alagramam, KN
AF Megerian, Cliff A.
Semaan, Maroun T.
Aftab, Saba
Kisley, Lauren B.
Zheng, Qing Yin
Pawlowski, Karen S.
Wright, Charles G.
Alagramam, Kumar N.
TI A mouse model with postnatal endolymphatic hydrops and hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE endolymphatic hydrops; Meniere's disease; Phex mutant
ID INNER-EAR; MENIERES-DISEASE; COCHLEAR NEURONS; MICE; DEAFNESS; DEFECTS;
GENE; DEGENERATION; PATHOGENESIS; MUTATION
AB Endolymphatic hydrops (ELH), hearing loss and neuronal degeneration occur together in a variety of clinically significant disorders, including Meniere's disease (MD). However, the sequence of these pathological changes and their relationship to each other are not well understood. In this regard, an animal model that spontaneously develops these features postnatally would be useful for research purposes. A search for such a model led us to the Phex(Hyp-Duk) mouse, a mutant allele of the Phex gene causing X-linked hypophosphatemic rickets. The hemizygous male (Phex(Hyp-Duk)/Y) was previously reported to exhibit various abnormalities during adulthood, including thickening of bone, ELH and hearing loss. The reported inner-ear phenotype was suggestive of progressive pathology and spontaneous development of ELH postnatally, but not conclusive. The main focuses of this report are to further characterize the inner ear phenotype in Phex(Hyp-Duk)/Y mice and to test the hypotheses that (a) the Phex(Hyp-Duk)/Y mouse develops ELH and hearing loss postnatally, and (b) the development of ELH in the Phex(Hyp-Duk)/Y mouse is associated with obstruction of the endolymphatic duct (ED) due to thickening of the surrounding bone. Auditory brainstem response (ABR) recordings at various times points and histological analysis of representative temporal bones reveal that Phex(Hyp-Duk)/Y mice typically develop adult onset, asymmetric, progressive hearing loss closely followed by the onset of ELH. ABR and histological data show that functional degeneration precedes structural degeneration. The major degenerative correlate of hearing loss and ELH in the mutants is the primary loss of spiral ganglion cells. Further, Phex(Hyp-Duk)/Y mice develop ELH without evidence of ED obstruction, supporting the idea that ELH can be induced by a mechanism other than the blockade of longitudinal flow of endolymphatic fluid, and occlusion of ED is not a prerequisite for the development of ELH in patients. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Megerian, Cliff A.; Semaan, Maroun T.; Aftab, Saba; Kisley, Lauren B.; Zheng, Qing Yin; Wright, Charles G.; Alagramam, Kumar N.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Cleveland, OH 44106 USA.
[Pawlowski, Karen S.; Wright, Charles G.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
RP Alagramam, KN (reprint author), Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM cliff.megerian@uhhospitals.org; maroun.semaan@uhhospitals.org;
saba.aftab@uhhospi-tals.org; lauren.kisley@case.edu; qyz@case.edu;
Pawlowski@UTSouthwestern.edu; cgwrigh@utdallas.edu; kna3@cwru.edu
RI Zheng, Qing/C-1731-2012
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NR 30
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2008
VL 237
IS 1-2
BP 90
EP 105
DI 10.1016/j.heares.2008.01.002
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 289IU
UT WOS:000255049000008
PM 18289812
ER
PT J
AU Breuskin, I
Bodson, M
Thelen, N
Thiry, M
Nguyen, L
Belachew, S
Lefebvre, PP
Malgrange, B
AF Breuskin, Ingrid
Bodson, Morgan
Thelen, Nicolas
Thiry, Marc
Nguyen, Laurent
Belachew, Shibeshih
Lefebvre, Philippe P.
Malgrange, Brigitte
TI Strategies to regenerate hair cells: Identification of progenitors and
critical genes
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; cochlea; development; regeneration
ID MAMMALIAN INNER-EAR; CYCLIN-DEPENDENT KINASES; NOTCH SIGNALING PATHWAY;
EMBRYONIC STEM-CELLS; MATURE GUINEA-PIGS; HEARING-LOSS; RETINOBLASTOMA
PROTEIN; SENSORY EPITHELIUM; MUTANT MICE; IN-VIVO
AB Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the auditory part of the inner ear. There are currently no treatments designed to halt or reverse the progression of hearing loss. A key goal in developing therapy for sensorineural deafness is the identification of strategies to replace lost hair cells. In amphibians and birds, a spontaneous post-injury regeneration of all inner ear sensory hair cells occurs. In contrast, in the mammalian cochlea, hair cells are only produced during embryogenesis.
Many studies have been carried out in order to demonstrate the persistence of endogenous progenitors. The present review is first focused on the occurrence of spontaneous supernumerary hair cells and on nestin positive precursors found in the organ of Corti. A second approach to regenerating hair cells would be to find genes essential for their differentiation. This review will also focus on critical genes for embryonic hair cell formation such as the cell cycle related proteins, the Atoh1 gene and the Notch signaling pathway. Understanding mechanisms that underlie hair cell production is an essential prerequisite to defining therapeutic strategies to regenerate hair cells in the mature inner ear. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Breuskin, Ingrid; Bodson, Morgan; Nguyen, Laurent; Belachew, Shibeshih; Lefebvre, Philippe P.; Malgrange, Brigitte] Univ Liege, Dev Neurobiol Unit, Ctr Cellular & Mol Neurosci, B-4000 Liege, Belgium.
[Breuskin, Ingrid; Lefebvre, Philippe P.] Univ Liege, Dept Otorhinolaryngol, B-4000 Liege, Belgium.
[Thelen, Nicolas; Thiry, Marc] Univ Liege, Cell Biol Unit, Ctr Cellular & Mol Neurosci, B-4000 Liege, Belgium.
[Belachew, Shibeshih] Univ Liege, Dept Neurol, B-4000 Liege, Belgium.
RP Malgrange, B (reprint author), Univ Liege, Dev Neurobiol Unit, Ctr Cellular & Mol Neurosci, B-4000 Liege, Belgium.
EM bmalgrange@ulg.ac.be
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NR 83
TC 9
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2007.08.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300001
PM 17920797
ER
PT J
AU Hu, BH
Henderson, D
Yang, WP
AF Hu, Bo Hua
Henderson, Donald
Yang, Wei Ping
TI The impact of mitochondrial energetic dysfunction on apoptosis in outer
hair cells of the cochlea following exposure to intense noise
SO HEARING RESEARCH
LA English
DT Article
DE apoptosis; necrosis; mitochondria; impulse noise; outer hair cell;
succinate dehydrogenase
ID INDUCED HEARING-LOSS; ATP-DEPENDENT STEPS; SUCCINATE-DEHYDROGENASE;
GUINEA-PIG; CHINCHILLA COCHLEA; IMPULSE NOISE; DEATH; NECROSIS;
3-NITROPROPIONATE; PATHWAY
AB Previous studies have shown that exposure to intense noise causes outer hair cells (OHCs) to die, primarily through the process of apoptotic degeneration. The current study was designed to examine the regulatory role of mitochondrial bioenergetic function in controlling the initiation and execution of the apoptotic process of OHCs. Chinchilla cochleae were treated with 3-nitropropionic acid (3-NP, 20 or 50 mM), an irreversible inhibitor of succinate dehydrogenase (SDH), to inhibit the mitochondrial energy production before and after exposure to 75 pairs of impulses at 155 dB pSPL. Comparison of the noise-exposed cochleae treated with and without 3-NP revealed that the inhibition of SDH activity delayed nuclear degradation in apoptotic OHCs. However, the initiation of apoptosis appeared to be undeterred. There was no major shift of cell death pathways from apoptosis to necrosis, although a small portion of OHCs showed signs of secondary necrosis. Collectively, the results of the study suggest that, while the mitochondrial energetic function plays an important role in regulating the apoptotic process, its dysfunction has a limited influence on the suppression of apoptotic induction in OHCs following exposure to intense noise. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Hu, Bo Hua; Henderson, Donald] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
[Yang, Wei Ping] Peoples Liberat Army Gen Hosp, Inst Otolaryngol, Beijing 1000853, Peoples R China.
RP Hu, BH (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM bhu@acsu.buffalo.edu; donald@acsu.buffalo.edu; yangwp2002@yahoo.com
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NR 33
TC 13
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 11
EP 21
DI 10.1016/j.heares.2007.11.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300002
PM 18082984
ER
PT J
AU Dai, C
Wood, MW
Gan, RZ
AF Dai, Chenkal
Wood, Mark W.
Gan, Rong Z.
TI Combined effect of fluid and pressure on middle ear function
SO HEARING RESEARCH
LA English
DT Article
DE laser vibrometer; middle ear mechanics; otitis media; temporal bone;
tympanometry
ID STATIC PRESSURE; PARS FLACCIDA; INTERFEROMETRY MEASUREMENTS; TYMPANIC
MEMBRANE; OTITIS-MEDIA; GERBIL; TYMPANOMETRY; DISPLACEMENT; EFFUSION
AB In our previous studies, the effects of effusion and pressure on sound transmission were investigated separately. The aim of this study is to investigate the combined effect of fluid and pressure on middle ear function. An otitis media with effusion model was created by injecting saline solution and air pressure simultaneously into the middle ear of human temporal bones. Tympanic membrane displacement in response to 90 dB SPL sound input was measured by a laser vibrometer and the compliance of the middle ear was measured by a tympanometer. The movement of the tympanic membrane at the umbo was reduced up to 17 dB by the combination of fluid and pressure in the middle ear over the auditory frequency range. The fluid and pressure effects on the umbo movement in the fluid-pressure combination are not additive. The combined effect of fluid and pressure on the umbo movement is different compared with that of only fluid or pressure change in the middle ear. Negative pressure in fluid-pressure combination had more effect on middle ear function than positive pressure. Tympanometry can detect the middle ear pressure of the fluid pressure combination. This study provides quantitative information for analysis of the combined effect of fluid and pressure on tympanic membrane movement. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Dai, Chenkal; Gan, Rong Z.] Univ Oklahoma, Sch Aerosp & Mech Engn, Norman, OK 73019 USA.
[Dai, Chenkal; Gan, Rong Z.] Univ Oklahoma, Ctr Bioengn, Norman, OK 73019 USA.
[Wood, Mark W.] House Ear Res Inst, Oklahoma City, OK 73112 USA.
RP Gan, RZ (reprint author), Univ Oklahoma, Sch Aerosp & Mech Engn, 865 Asp Ave,Room 200, Norman, OK 73019 USA.
EM rgan@ou.edu
RI dai, chenkai/A-8051-2010
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NR 15
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 22
EP 32
DI 10.1016/j.heares.2007.11.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300003
PM 18162348
ER
PT J
AU Severinsen, SA
Raarup, MK
Ulfendahl, M
Wogensen, L
Nyengaard, JR
Kirkegaard, M
AF Severinsen, Stig A.
Raarup, Merete K.
Ulfendahl, Mats
Wogensen, Lise
Nyengaard, Jens R.
Kirkegaard, Mette
TI Type I hair cell degeneration in the utricular macula of the waltzing
guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; waltzing guinea pig; stereology; utricular macula
ID UNBIASED STEREOLOGICAL ESTIMATION; POSTNATAL-DEVELOPMENT; COCHLEAR
POTENTIALS; STRAIN; MOUSE; PATHOLOGY; ACTIN; MORPHOLOGY; DEAFNESS;
NUMBER
AB Waltzing guinea pigs are an inbred guinea pig strain with a congenital and progressive balance and hearing disorder. A unique rod-shaped structure is found in the type I vestibular hair cells, that traverses the cell in an axial direction, extending towards the basement membrane. The present study estimates the total number of utricular hair cells and supporting cells in waltzing guinea pigs and age-matched control animals using the optical fractionator method. Animals were divided into four age groups (1, 7, 49 and 343 day-old). The Dumber of type I hair cells decreased by 20% in the 343 day-old waltzing guinea pigs compared to age-matched controls and younger animals. Two-photon confocal laser scanning microscopy using antibodies against fimbrin and beta III-tubulin showed that the rods were exclusive to type I hair cells. There was no significant change in the length of the filament rods with age. Taken together, our data show that despite rod formation in the type I hair cells and deformation of hair bundles being present at birth, the type I hair cell population is not affected quantitatively until a year after birth. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Ulfendahl, Mats; Kirkegaard, Mette] Karolinska Inst, Dept Clin Neurosci, Ctr Hearing & Commun Res, Stockholm, Sweden.
[Severinsen, Stig A.; Raarup, Merete K.; Nyengaard, Jens R.] Univ Aarhus, Inst Clin Med, Mind Ctr, DK-8000 Aarhus C, Denmark.
[Severinsen, Stig A.; Raarup, Merete K.; Nyengaard, Jens R.] Univ Aarhus, Inst Clin Med, Stereol & Electron Microscopy Res Lab, DK-8000 Aarhus, Denmark.
[Ulfendahl, Mats; Kirkegaard, Mette] Karolinska Univ Hosp, Dept Otolaryngol, SE-17176 Stockholm, Sweden.
[Wogensen, Lise] Aarhus Univ, Inst Clin Med, Res Lab Biochem Pathol, DK-8000 Aarhus C, Denmark.
RP Kirkegaard, M (reprint author), Karolinska Inst, Dept Clin Neurosci, Ctr Hearing & Commun Res, Stockholm, Sweden.
EM mette.kirkegaard@ki.se
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NR 38
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 33
EP 41
DI 10.1016/j.heares.2007.11.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300004
PM 18191927
ER
PT J
AU Wang, HT
Luo, B
Huang, YN
Zhou, KQ
Chen, L
AF Wang, Hai-Tao
Luo, Bin
Huang, Yi-Na
Zhou, Ke-Qing
Chen, Lin
TI Sodium salicylate suppresses serotonin-induced enhancement of GABAergic
spontaneous inhibitory postsynaptic currents in rat inferior colliculus
in vitro
SO HEARING RESEARCH
LA English
DT Article
DE serotonin; GABAergic spontaneous inhibitory postsynaptic current;
tinnitus; sodium salicylate; brain slice; inferior colliculus
ID PREFRONTAL CORTEX; AUDITORY-CORTEX; CEREBRAL-CORTEX; INDUCED TINNITUS;
5-HT3 RECEPTORS; NEURAL ACTIVITY; ANIMAL-MODEL; NEURONS; INTERNEURONS;
GABA
AB Available evidence suggests that sodium salicylate (SS) may produce tinnitus through altering the balance between inhibition and excitation in the central auditory system. Since serotonin (5-hydroxytryptamine, 5-HT) containing fibers preferentially innervate inhibitory GABA neurons, there exists a possibility that SS causes the imbalance between inhibition and excitation through influencing serotonergic modulation of the GABAergic synaptic transmission. In the present study, we examined the effects of SS on 5-HT-mediated GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) from neurons of the central nucleus of rat inferior colliculus with whole-cell patch-clamp technique and brain slice preparation. Perfusion of 40 mu M 5-HT robustly enhanced both frequency and amplitude of GABAergic sIPSCs and this 5-HT-induced enhancement of GABAergic sIPSCs could be suppressed by 1.4 mM SS. Tetrodotoxin at 0.5 mu M produced a similar effect as SS did, suggesting that SS suppresses the 5-HT-induced enhancement of GABAergic sIPSCs through depressing spontaneous action potentials of GABA neurons. Our findings suggest that SS may preferentially target GABA neurons and consequently interrupt a normal level of GABAergic synaptic transmissions maintained by the serotonergic system in SS-induced tinnitus. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Wang, Hai-Tao; Luo, Bin; Huang, Yi-Na; Chen, Lin] Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China.
[Wang, Hai-Tao; Luo, Bin; Huang, Yi-Na; Chen, Lin] Univ Sci & Technol China, Hefei Nat Lab Phys Sci Microscale, Hefei 230027, Peoples R China.
[Zhou, Ke-Qing] Univ Sci & Technol China, Lab Receptor Pharmacol, Hefei 230027, Peoples R China.
RP Chen, L (reprint author), Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China.
EM linchen@ustc.edu.cn
RI Chen, Lin/N-8327-2013
OI Chen, Lin/0000-0002-5847-2989
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NR 53
TC 25
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 42
EP 51
DI 10.1016/j.heares.2007.11.015
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300005
PM 18222054
ER
PT J
AU Qi, WD
Ding, DL
Salvi, RJ
AF Qi, Weidong
Ding, Dalian
Salvi, Richard J.
TI Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic
cultures
SO HEARING RESEARCH
LA English
DT Article
DE dimethyl sulphoxide; hair cells; cochlear organotypic culture;
apoptosis; caspase-8; caspase-9; mitochondria; TUNEL
ID HAIR CELL ELECTROMOTILITY; INDUCED HEARING-LOSS; INTRACELLULAR CALCIUM;
PROTECTS COCHLEAR; INDUCED APOPTOSIS; LYMPHOMA-CELLS; ION-TRANSPORT;
DIMETHYLSULFOXIDE; CISPLATIN; DEATH
AB The amphipathic molecule dimethyl sulphoxide (DMSO) is a solvent often used to dissolve compounds applied to the inner ear; however, little is known about its potential cytotoxic side effects. To address this question, we applied 0.1-6% DMSO for 24 h to cochlear organotypic cultures from postnatal day 3 rats and examined its cytotoxic effects. DMSO concentrations of 0.1% and 0.25% caused little or no damage. However, concentrations between 0.5% and 6% resulted in stereocilia damage, hair cell swelling and a dose-dependent loss of hair cells. Hair cell damage began in the basal turn of the cochlea and spread towards the apex with increasing concentration. Surprisingly, DMSO-induced damage was greater for inner hair cells than outer hair cell whereas nearby supporting cells were largely unaffected. Most hair cell death was associated with nuclear shrinkage and fragmentation, morphological features consistent with apoptosis. DMSO treatment induced TUNEL-positive staining in many hair cells and activated both initiator caspase-9 and caspase-8 and executioner caspase-3; this suggests that apoptosis is initiated by both intrinsic mitochondrial and extrinsic membrane cell death signaling pathways. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Qi, Weidong; Ding, Dalian; Salvi, Richard J.] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
[Qi, Weidong; Ding, Dalian] Fudan Univ, Huashan Hosp, Dept Otolaryngol Head & Neck Surg, Shanghai 200040, Peoples R China.
RP Salvi, RJ (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall, Buffalo, NY 14214 USA.
EM salvi@buffalo.edu
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NR 46
TC 45
Z9 52
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 52
EP 60
DI 10.1016/j.heares.2007.12.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300006
PM 18207679
ER
PT J
AU Sussman, E
Stemschneider, M
Gumenyuk, V
Grushko, J
Lawson, K
AF Sussman, E.
Stemschneider, M.
Gumenyuk, V.
Grushko, J.
Lawson, K.
TI The maturation of human evoked brain potentials to sounds presented at
different stimulus rates
SO HEARING RESEARCH
LA English
DT Article
DE auditory; event-related potentials (ERPs); maturation; cortex; children;
adolescents
ID AUDITORY-SYSTEM ACTIVITY; EVENT-RELATED POTENTIALS; AGE-RELATED-CHANGES;
DEVELOPMENTAL-CHANGES; LANGUAGE-DEVELOPMENT; GAP DETECTION; N1 WAVE;
CHILDREN; COMPONENT; RESPONSES
AB The current study assessed the normal development of cortical auditory evoked potentials (CAEPs) in humans presented with pure tone stimuli at relatively fast stimulus rates. Traditionally, maturation of sound processing indexed by CAEPs has been studied in paradigms using inter-stimulus intervals (ISIs) generally slower than 1 Hz. While long ISIs may enhance the amplitude of CAEP components, speech information generally occurs at more rapid rates. These slower rates of sound presentation may not accurately assess auditory cortical functions in more realistic sound environments. We examined the effect of temporal rate on the elicitation of the P1-N1-P2-N2 components to unattended sounds at four levels of stimulus onset asynchrony (SOA, onset to onset, 200, 400, 600, and 800 ms) in children grouped separately by year (ages 8, 9, 10, 11 years), in adolescents (age 16 years) and in one group of young adults (ages 22-40 years). We found that both age and stimulus rate produced profound changes in CAEP morphology. Between the ages of 8-11 years, the P1 and N2 components dominated the ERP waveform at all stimulus rates. N1, the dominant CAEP component in adults, appeared as a bifurcation in a broad positive peak at earlier ages, and did not emerge as a separate component until adolescence. While the P1-N1-P2 components are more "adult-like" than "child-like" in the adolescent subjects, the N2 component, a hallmark of the child obligatory response, was still present. Faster rates resulted in the suppression of discrete components such that by 200 ms, only P1 in the adults and adolescents, and both P1 and N2 in the youngest children were discernable. We conclude that both age and ISI are important variables in the assessment of auditory cortex function and maturation. The presence of N2 in adolescents indicates that auditory cortical maturation persists into teen years. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Sussman, E.; Stemschneider, M.; Gumenyuk, V.; Grushko, J.] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA.
[Sussman, E.] Albert Einstein Coll Med, Dept Otorhinolaryngol HNS, Bronx, NY 10461 USA.
[Stemschneider, M.] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA.
[Lawson, K.] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.
RP Sussman, E (reprint author), Albert Einstein Coll Med, Dept Neurosci, 1410 Pelham Pkwy S, Bronx, NY 10461 USA.
EM esussman@aecom.yu.edu
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NR 59
TC 76
Z9 82
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2008
VL 236
IS 1-2
BP 61
EP 79
DI 10.1016/j.heares.2007.12.001
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 277WL
UT WOS:000254245300007
PM 18207681
ER
PT J
AU Torkos, A
Wissel, K
Warnecke, A
Lenarz, T
Stover, T
AF Torkos, Attila
Wissel, Kirsten
Warnecke, Athanasia
Lenarz, Thomas
Stoever, Timo
TI Technical report: Laser microdissection and pressure catapulting is
superior to conventional manual dissection for isolating pure spiral
ganglion fractions from the cochlea
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; gene expression analysis; laser microdissection pressure
catapulting; manual dissection; spiral ganglion cells
ID POLYMERASE CHAIN-REACTION; MATURE RAT COCHLEA; OUTER HAIR-CELLS;
NEUROTROPHIC FACTOR; INNER-EAR; CAPTURE MICRODISSECTION; EXPRESSION;
NEUROFILAMENT; TISSUE; PROTEINS
AB Isolating cells from the cochlea to perform molecular biology assessment presents a challenge, because it is not possible to dissect pure cell pools by conventional methods. Thus, we set out to demonstrate that laser microdissection and pressure catapulting (LMPC) is superior to conventional manual cochlea dissection for this purpose. Spiral ganglions (SG) were isolated from neonatal rat cochleae by manual dissection and LMPC. Also, modioli were manually dissected. Total RNA was isolated from all three cell pools. In order to demonstrate contamination of the dissected cell pool, we determined the expression of type II iodothyronine deiodinase (D2), claudin 11 (Cld-11), neurofilament light chain (NF-L) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) transcripts by RT-PCR. The results showed that LMPC is not only a suitable method for selectively dissecting cochlear tissues, but in addition the molecular markers confirmed pure spiral ganglion cell pools without indication for any contamination by other cells. This indicates that LMPC is capable of providing a pure SG cell pool in contrast to conventional manual dissection. Therefore, LMPC presents a new technique for cochlear tissue separation improving the validity of molecular biological studies of the inner ear. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Torkos, Attila; Wissel, Kirsten; Warnecke, Athanasia; Lenarz, Thomas; Stoever, Timo] Hannover Med Sch, Dept Otorhinolaryngol, D-30625 Hannover, Germany.
[Torkos, Attila] Univ Szeged, Dept Otorhinolaryngol & Head & Neck Surg, H-6725 Szeged, Hungary.
RP Wissel, K (reprint author), Hannover Med Sch, Dept Otorhinolaryngol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kirsten.wissel@gmx.de
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NR 19
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 8
EP 14
DI 10.1016/j.heares.2007.09.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000002
PM 17980526
ER
PT J
AU Avallone, B
Fascio, U
Balsamo, G
Marino, F
AF Avallone, Bice
Fascio, Umberto
Balsamo, Giuseppe
Marino, Francesco
TI Gentamicin ototoxicity in the saccule of the lizard Podarcis Sicula
induces hair cell recovery and regeneration
SO HEARING RESEARCH
LA English
DT Article
DE aminoglycoside antibiotics; calbindin; BrdU; inner ear; recovery
ID PERIPHERAL VESTIBULAR SYSTEM; AVIAN INNER-EAR; ACOUSTIC TRAUMA;
AMINOGLYCOSIDE TOXICITY; CRISTA-AMPULLARIS; BASILAR PAPILLA; OTOLITH
ORGANS; CHICK COCHLEA; GUINEA-PIG; LOCALIZATION
AB There is little information available on the susceptibility of reptilian saccule hair cells to ototoxin-induced sensory damage. In this study, we report morphological evidence of hair cell recovery and regeneration after damage induced by gentamicin in the saccule of a lizard. We perform morphological analysis using scanning electron microscopy and confocal laser scanning microscopy with actin and calbindin as markers for hair cells and tubulin as a marker for supporting cells. The data were consistent: gentamicin induced damage in the hair cells, and the damage increased with increasing duration of treatment. Initially, the saccule appeared unhealthy. Subsequently, the sensory hair cells became compromised, with fused stereovilli, followed by widespread loss of hair cell bundles from the hair cells. Finally, numerous hair cells were lost. Morphologically, the saccule appeared normal 28 days after gentamicin treatment. Using a mitogenic marker, we tested whether or not there is hair cell regeneration following administration of gentamicin. We found evidence of bromodeoxyuridine incorporation first in supporting cell nuclei and subsequently in hair cell nuclei. This indicates that a process of sensory epithelium repair and hair cell regeneration occurred, in both extrastriolar and striolar regions, and that the recovery was due to both the proliferation of supporting cells and, as seems likely, self-repair of hair cell bundles. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Avallone, Bice; Balsamo, Giuseppe; Marino, Francesco] Univ Naples Federico 2, Dept Biol Sci, Mol Genet & Mol Biol, I-80134 Naples, Italy.
[Fascio, Umberto] Univ Milan, CIMA, I-20133 Milan, Italy.
RP Avallone, B (reprint author), Univ Naples Federico 2, Dept Biol Sci, Mol Genet & Mol Biol, Via Mezzocannone 8, I-80134 Naples, Italy.
EM bice.avallone@unina.it
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NR 36
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 15
EP 22
DI 10.1016/j.heares.2007.09.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000003
PM 17980524
ER
PT J
AU Snyder, RL
Middlebrooks, JC
Bonham, BH
AF Snyder, Russell L.
Middlebrooks, John C.
Bonham, Ben H.
TI Cochlear implant electrode configuration effects on activation threshold
and tonotopic selectivity
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; cochlear prosthesis; deafness; auditory nervous
system; multichannel recording; auditory prosthesis; inferior colliculus
ID INTRACOCHLEAR ELECTRICAL-STIMULATION; ROTATIONALLY SYMMETRICAL MODEL;
AUDITORY-NERVE; EXCITATION PATTERNS; NEURAL EXCITATION; PITCH RANKING;
INFERIOR COLLICULUS; SPEECH-RECOGNITION; INSERTION TRAUMA; TEMPORAL BONE
AB The multichannel design of contemporary cochlear implants (CIs) is predicated on the assumption that each channel activates a relatively restricted and independent sector of the deaf auditory nerve array, just as a sound within a restricted frequency band activates a restricted region of the normal cochlea The independence of CI channels, however, is limited; and the factors that determine their independence, the relative overlap of the activity patterns that they evoke, are poorly understood. In this study, we evaluate the spread of activity evoked by cochlear implant channels by monitoring activity at 16 sites along the tonotopic axis of the guinea pig inferior colliculus (IC). "Spatial tuning curves" (STCs) measured in this way serve as an estimate of activation spread within the cochlea and the ascending auditory pathways. We contrast natural stimulation using acoustic tones with two kinds of electrical stimulation either (1) a loose fitting banded array consisting of a cylindrical silicone elastomer carrier with a linear series of ring contacts; or (2) a space-filling array consisting of a tapered silicone elastomer carrier that is designed to fit snugly into the guinea pig scala tympani with a linear series of ball contacts positioned along it Spatial tuning curves evoked by individual acoustic tones, and by activation of each contact of each array as a monopole, bipole or tripole were recorded. Several channel configurations and a wide range of electrode separations were tested for each array, and their thresholds and selectivity were estimated.
The results indicate that the tapered space-filling arrays evoked more restricted activity patterns at lower thresholds than did the banded arrays. Monopolar stimulation (one intracochlear contact activated with an extracochlear return) using either array evoked broad activation patterns that involved the entire recording array at current levels <6 dB SL, but at relatively low thresholds. Bi- and tri-polar configurations of both array types evoked more restricted activity patterns, but their thresholds were higher than those of monopolar configurations. Bipolar and tripolar configurations with closely spaced contacts evoked activity patterns that were comparable to those evoked by pure tones. As the spacing of bipolar electrodes was increased (separations >1 mm), the activity patterns became broader and evoked patterns with two distinct threshold minima, one associated with each contact. Published by Elsevier B.V.
C1 [Snyder, Russell L.; Bonham, Ben H.] Univ Calif San Francisco, Dept Otolaryngol HNS, Epstein Lab, San Francisco, CA 94143 USA.
[Middlebrooks, John C.] Univ Michigan, Kresge Hearing Res Inst, Neurosci Program, Ann Arbor, MI 48109 USA.
[Snyder, Russell L.] Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
RP Snyder, RL (reprint author), Univ Calif San Francisco, Dept Otolaryngol HNS, Epstein Lab, Box 0526,U490, San Francisco, CA 94143 USA.
EM rsnyder@itsa.ucsf.edu
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NR 62
TC 41
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 23
EP 38
DI 10.1016/j.heares.2007.09.013
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000004
PM 18037252
ER
PT J
AU Miko, IJ
Henkemeyer, M
Cramer, KS
AF Miko, Ilona J.
Henkemeyer, Mark
Cramer, Karina S.
TI Auditory brainstem responses are impaired in EphA4 and ephrin-B2
deficient mice
SO HEARING RESEARCH
LA English
DT Article
DE brainstem; ABR; Eph receptor; ephrin; mouse
ID MOUSE INNER-EAR; AXONAL GROWTH; CELL BEHAVIOR; HEARING-LOSS; MUTANT
MICE; GUINEA-PIG; RECEPTORS; EPHB2; EXPRESSION; SYSTEM
AB The Eph receptor tyrosine kinases and their membrane-anchored ligands, ephrins, are signaling proteins that act as axon guidance molecules during chick auditory brainstem development. We recently showed that Eph proteins also affect patterns of neural activation in the mammalian brainstem. However, functional deficits in the brainstems of mutant mice have not been assessed physiologically. The present study characterizes neural activation in Eph protein deficient mice in the auditory brainstem response (ABR). We recorded the A BR of EphA4 and ephrin-B2 mutant mice, aged postnatal day 18-20, and compared them to wild type controls. The peripheral hearing threshold of EphA4(-/-) mice was 75% higher than that of controls. Waveform amplitudes of peak 1 (P1) were 54% lower in EphA4(-/-) mice than in controls. The peripheral hearing thresholds in ephrin-B2(lacZI+) mice were also elevated, with a mean value 20% higher than that of controls. These ephrin-B2(lacZI+) mice showed a 38% smaller P1 amplitude. Significant differences in latency to waveform peaks were also observed. These elevated thresholds and reduced peak amplitudes provide evidence for hearing deficits in both of these mutant mouse lines, and further emphasize an important role for Eph family proteins in the formation of functional auditory circuitry. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Miko, Ilona J.; Cramer, Karina S.] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA.
[Henkemeyer, Mark] UT SW Med Ctr, Dept Dev Biol, Dallas, TX USA.
RP Cramer, KS (reprint author), Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA.
EM cramerk@uci.edu
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NR 45
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 39
EP 46
DI 10.1016/j.heares.2007.09.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000005
PM 17967521
ER
PT J
AU Smith, JL
Sterns, AR
Prieve, BA
Woods, CI
AF Smith, Joseph L., II
Sterns, Anita R.
Prieve, Beth A.
Woods, Charles I.
TI Effects of anesthesia on DPOAE level and phase in rats
SO HEARING RESEARCH
LA English
DT Article
DE DPOAEs; DPOAE onset adaptation; contralateral suppression; middle ear
muscle reflex; rat; anesthesia; medial olivocochlear reflex
ID PRODUCT OTOACOUSTIC EMISSIONS; SINGLE OLIVOCOCHLEAR NEURONS; COMPOUND
ACTION-POTENTIALS; GUINEA-PIG; INFERIOR COLLICULUS; MIDDLE-EAR; RESPONSE
PROPERTIES; ACOUSTIC REFLEX; ADAPTATION; SOUND
AB Many studies of the auditory system are performed on animals under general anesthesia. A concern for researchers is that these agents may significantly alter the underlying neurophysio logic mechanisms being studied. The effects may very across species, and even among individuals within a species. An investigation was undertaken to study whether DPOAE measures differ using three different anesthetic regimens: acetylpromazine-ketamine, xylazine-ketamine, and sodium pentobarbital. The same rat was anesthetized in three consecutive weeks using a different anesthetic regimen each week. DPOAE magnitude and phase temporal responses were recorded from which several measures were taken: DPOAE levels at the onset of the primaries, changes in DPOAE level as a function of time during presentation of the primaries (Delta LI) and changes in DPOAE level (Delta LC) and phase (Delta PC) during presentation of a broad-band noise presented contralateral to the probe. Each week the same measurements were repeated with the rat anesthetized using a different regimen and at the end of the third week, the middle ear muscles were sectioned and the measurements repeated once again. Results showed that the anesthetic regimens did not differentially alter the DPOAE onset levels. When sodium pentobarbital was used as the anesthetic regimen, Delta LC and Delta PC were significantly smaller relative to those measured when the rats were anesthetized with acetylpromazine-ketamine and xylazine-ketamine. Based on the assumption that large, positive (Delta PC) values are related to middle ear muscle activation, the middle ear muscle reflex remained at least partially active in some rats under sodium pentobarbital anesthesia. The Delta LI measures were significantly smaller when the animals were anesthetized with xylazine-ketamine and sodium pentobarbital than when they were anesthetized with acetylpromazine-ketamine. Recordings taken after sectioning the middle ear muscles suggested that the middle ear muscle reflex substantially contributes to Delta LC and Delta PC measures under the anesthetic regimens xylazine-ketamine and acetylpromazine-ketamine. Data indicated that anesthetic agents variably alter neurophysiologic mechanisms involved with the complex control of the auditory signal even among individuals in the same species. Extreme care should be taken when comparing Delta LI, Delta LC and Delta PC across studies when different anesthetic regimens are used within and across species. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Sterns, Anita R.; Prieve, Beth A.; Woods, Charles I.] Syracuse Univ, Inst Sensory Res, Syracuse, NY 13244 USA.
[Smith, Joseph L., II; Woods, Charles I.] Upstate Med Univ, Dept Otolaryngol & Commun Sci, Syracuse, NY USA.
[Prieve, Beth A.] Dept Commun Sci & Disorders, Syracuse, NY USA.
RP Prieve, BA (reprint author), Syracuse Univ, Inst Sensory Res, 621 Skytop Rd, Syracuse, NY 13244 USA.
EM baprieve@syr.edu
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NR 41
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 47
EP 59
DI 10.1016/j.heares.2007.09.010
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000006
PM 18023304
ER
PT J
AU Willott, JF
VandenBosche, J
Shimizu, T
Ding, DL
Salvi, R
AF Willott, James F.
VandenBosche, Justine
Shimizu, Toru
Ding, Da-Lian
Salvi, Richard
TI Effects of exposing C57BL/6J mice to high- and low-frequency augmented
acoustic environments: Auditory brainstem response thresholds,
cytocochleograms, anterior cochlear nucleus morphology and the role of
gonadal hormones
SO HEARING RESEARCH
LA English
DT Article
DE mouse; ABR; augmented acoustic environment; hearing loss; cochleograms;
hair cells; gonadal hormones; sex differences
ID PRODUCT OTOACOUSTIC EMISSIONS; INDUCED HEARING-LOSS; AGING C57BL-6J
MICE; SEX-DIFFERENCES; PROLONGED EXPOSURE; IMPULSE NOISE; MOUSE MODELS;
DBA/2J MICE; AGE; ESTRADIOL
AB Gonadectomized and intact adult C57BL/6J (136) mice of both sexes were exposed for 12 It nightly to an augmented acoustic environment (AAE): repetitive bursts of a 70 dB SPL noise band. The high-frequency AAE (HAAE) was a half-octave band centered at 20 kHz; the low-frequency AAE (LAAE) was a 2-8 kHz band. The effects of sex, gonadectomy, and AAE treatment on genetic progressive hearing loss (a trait of B6 mice) were evaluated by obtaining auditory brainstem response (ABR) thresholds at ages 3-, 6-, and 9-months. At 9-months of age, hair cell counts (cytocochleograms) were obtained, and morphometric measures of the anteroventral cochlear nucleus (AVCN) were obtained. LAAE treatment caused elevation in ABR thresholds (8-24 kHz), with the highest thresholds occurring in intact females. LAAE treatment caused some loss of outer hair cells in the basal half of the cochlea (in addition to losses normally occurring in 136 mice), with intact females losing more cells than intact males. The loss of AWN neurons and shrinkage of tissue volume that typically occur in 9-month-old B6 mice was lessened by LAAE treatment in intact (but not gonadectomized) male mice, whereas the degenerative changes were exacerbated in intact (but not gonadectomized) females. These LAAE effects were prominent in, but not restricted to, the tonotopic low-frequency (ventral) AWN. HAAE treatment resulted in some loss of neurons in the high-frequency (dorsal) AWN. In general, LAAE treatment plus male gonadal hormones (intact males) had an ameliorative effect whereas HAAE or LAAE treatment plus ovarian hormones (intact females) had a negative effect on age-related changes in the B6 auditory system. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Willott, James F.; VandenBosche, Justine; Shimizu, Toru] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA.
[Willott, James F.] Jackson Lab, Bar Harbor, ME 04609 USA.
[Ding, Da-Lian] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Willott, JF (reprint author), Univ S Florida, Dept Psychol, 4202 E Fowler Ave PCD4118G, Tampa, FL 33620 USA.
EM jimw@niu.edu
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NR 42
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 60
EP 71
DI 10.1016/j.heares.2007.10.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000007
PM 18077117
ER
PT J
AU Eckrich, T
Foeller, E
Stuermer, IW
Gaese, BH
Kossl, M
AF Eckrich, Tobias
Foeller, Elisabeth
Stuermer, Ingo W.
Gaese, Bernhard H.
Koessl, Manfred
TI Strain-dependence of age-related cochlear hearing loss in wild and
domesticated Mongolian gerbils
SO HEARING RESEARCH
LA English
DT Article
DE DPOAE; Otoacoustic emission; cochlear mechanics; Meriones unguiculatus
ID PRODUCT OTOACOUSTIC EMISSIONS; AUDITORY-EVOKED POTENTIALS;
MERIONES-UNGUICULATUS; MOUSTACHED BAT; PTERONOTUS-PARNELLII; LABORATORY
GERBILS; F1-HYBRID STRAINS; CBA MICE; SENSITIVITY; QUIET
AB The Mongolian gerbil (Meriones unguiculatus) is one of the animal models in auditory research that has been used in several studies on age-related hearing loss. The standard laboratory strain is domesticated as it was bred in captivity for more than 70 years. We compared properties of distortion product otoacoustic emissions (DPOAEs) in domesticated gerbils with wild-type gerbils from F6-F7 generations of a strain originating from animals trapped in Central Asia in 1995. Up to an age of 9 months, DPOAE thresholds were comparable between both strains and were below 10 dB SPL for f2 frequencies between 4 and 44 kHz. In older domesticated animals, the thresholds were increased by up to 12 dB. Significant increases were found at stimulus frequencies of 2 kHz, 12-20 kHz, and 5660 kHz. The best frequency ratio f2/f1 to evoke maximum DPOAE amplitude was larger in domesticated animals at the age of 9 months or older. While these data show that there is a deterioration of cochlear sensitivity due to domestication, the magnitude of the described changes is small. Thus, the general suitability of domesticated gerbils for auditory research seems not to be affected. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Eckrich, Tobias; Foeller, Elisabeth; Gaese, Bernhard H.; Koessl, Manfred] Univ Frankfurt, Inst Zellbiol & Neurowissenschaft, D-60323 Frankfurt, Germany.
[Stuermer, Ingo W.] Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Dept Morphol Syst & Biol Evolut, Mammalian Res Grp, D-37073 Gottingen, Germany.
RP Gaese, BH (reprint author), Univ Frankfurt, Inst Zellbiol & Neurowissenschaft, Siesmayerstr 70A, D-60323 Frankfurt, Germany.
EM gaese@bio.uni-frankfurt.de
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NR 40
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 72
EP 79
DI 10.1016/j.heares.2007.10.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000008
PM 18037594
ER
PT J
AU Jedrzejczak, WW
Smurzynski, J
Blinowska, KJ
AF Jedrzejczak, W. Wiktor
Smurzynski, Jacek
Blinowska, Katarzyna J.
TI Origin of suppression of otoacoustic emissions evoked by two-tone bursts
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; two-tone suppression; time-frequency
distribution; adaptive approximations
ID FREQUENCY; PERCEPTION; MECHANICS; NOISE; MODEL; EARS
AB Otoacoustic emission (OAE) data recorded for tone bursts presented separately and as a two-tone burst complex, that had been reported previously [Yoshikawa, H., Smurzynski, J., Probst R., 2000. Suppression of tone burst evoked otoacoustic emissions in relation to frequency separation. Hear. Res. 148, 95-106], were re-processed using the method of adaptive approximations by matching pursuit (MP). Two types of stimuli were applied to record tone burst OAEs (TBOAEs): (a) cosine-windowed tone bursts of 5-ms duration with center frequencies of 1, 1.5, 2 and 3 kHz, (b) complex stimuli consisting of a digital addition of the 1 -kHz tone burst together with either the 1.5-, 2- or 3-kHz tone burst. The MP method allowed decomposition of signals into waveforms of defined frequency, latency, time span, and amplitude. This approach provided a high time-frequency (t-f) resolution and identified patterns of resonance modes that were characteristic for TBOAEs recorded in each individual ear. Individual responses to single-tone bursts were processed off-line to form,sum of singles' responses. The results confirmed linear superposition behavior for a frequency separation of two-tone bursts of 2 kHz (the 1-kHz and 3-kHz condition). For the 1, 1.5-kHz condition, the MP results revealed the existence of closely positioned resonance modes associated with responses recorded individually with the stimuli differing in frequency by 500 Hz. Then, the differences between t-f distributions calculated for dual (two-tone bursts) and sum-of-singles conditions exhibited mutual suppression of resonance modes common to both stimuli. The degree of attenuation depended on the individual pattern of characteristic resonance modes, i.e., suppression occurred when two resonant modes excited by both stimuli overlapped. It was postulated that the suppression observed in case of dual stimuli with closely-spaced components is due to mutual attenuation of the overlapping resonance modes. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Jedrzejczak, W. Wiktor] Inst Physiol & Pathol Hearing, PL-01943 Warsaw, Poland.
[Smurzynski, Jacek] E Tennessee State Univ, Dept Commun Disorders, Johnson City, TN 37614 USA.
[Blinowska, Katarzyna J.] Warsaw Univ, Inst Expt Phys, Dept Biomed Phys, PL-00681 Warsaw, Poland.
RP Jedrzejczak, WW (reprint author), Inst Physiol & Pathol Hearing, Ul Zgrupowania AK Kampinos 1, PL-01943 Warsaw, Poland.
EM w.jedrzejczak@ifps.org.pl
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NR 26
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 80
EP 89
DI 10.1016/j.heares.2007.10.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000009
PM 18082347
ER
PT J
AU Tan, XD
Wang, X
Yang, WG
Xiao, ZJ
AF Tan, Xiaodong
Wang, Xiao
Yang, Weiguo
Xiao, Zhonju
TI First spike latency and spike count as functions of tone amplitude and
frequency in the inferior colliculus of mice
SO HEARING RESEARCH
LA English
DT Article
DE spike rate; neuron; auditory system
ID PRIMARY AUDITORY-CORTEX; SINGLE-UNIT RESPONSES; MEDIAL GENICULATE-BODY;
DORSAL COCHLEAR NUCLEUS; RATE-LEVEL FUNCTIONS; NERVE FIBERS; DISCHARGE
CHARACTERISTICS; LATERAL LEMNISCUS; BASILAR-MEMBRANE; ECHOLOCATING BAT
AB Spike counts (SC) or, spike rate and first spike latency (FSL), are both used to evaluate the responses of neurons to amplitudes and frequencies of acoustic stimuli. However, it is unclear which one is more suitable as a parameter for evaluating the responses of neurons to acoustic amplitudes and frequencies, since systematic comparisons between SC and FSL tuned to different amplitudes and frequencies, are scarce. This study systematically compared the precision and stability (i.e., the resolution and the coefficient variation, CV) of SC- and FSL-function as frequencies and amplitudes in the inferior colliculus of mice. The results showed that: (1) the SC-amplitude functions were of diverse shape (monotonic, nonmonotonic and saturated) whereas the FSL-amplitude functions were in close registration, in which FSL decreased with the increase of amplitude and no paradoxical (an increase in FSL with increasing amplitude) or constant (an independence of FSL on amplitude) neuron was observed; (2) the discriminability (resolution) of differences in amplitude and frequency based on FSL are higher than those based on SC; (3) the CVs of FSL for low amplitude stimuli were smaller than those of SC; (4) the fraction of neurons for which BF = CF (within +/-500 Hz) obtained from FSL was higher than that from SC at any amplitude of sound. Therefore, SC and FSL may vary, independent from each other and represent different parameters of an acoustic stimulus, but FSL with its precision and stability appears to be a better parameter than SC in evaluation of the response of a neuron to frequency and amplitude in mouse inferior colliculus. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Tan, Xiaodong; Wang, Xiao; Yang, Weiguo; Xiao, Zhonju] So Med Univ, Basic Med Sch, Dept Physiol, Guangzhou 510515, Guangdong, Peoples R China.
RP Xiao, ZJ (reprint author), So Med Univ, Basic Med Sch, Dept Physiol, Guangzhou 510515, Guangdong, Peoples R China.
EM xiaozj@fimmu.com
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NR 82
TC 11
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 90
EP 104
DI 10.1016/j.heares.2007.10.002
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000010
PM 18037595
ER
PT J
AU Menard, M
Gallego, S
Berger-Vachon, C
Collet, L
Thai-Van, H
AF Menard, Mikael
Gallego, Stephane
Berger-Vachon, Christian
Collet, Lionel
Thai-Van, Hung
TI Relationship between loudness growth function and auditory steady-state
response in normal-hearing subjects
SO HEARING RESEARCH
LA English
DT Article
DE objective responses; psychoacoustic measures; loudness level
ID BRAIN-STEM RESPONSE; OTOACOUSTIC EMISSIONS; OBJECTIVE ESTIMATION;
EVOKED-POTENTIALS; MODULATED TONES; 80 HZ; FREQUENCY; THRESHOLDS;
AMPLITUDE; AUDIOMETRY
AB The present study investigates the relationship between auditory steady-state responses (ASSRs) and loudness growth function. ASSR amplitudes were compared to the perceived loudness level at frequencies of 500 and 2000 Hz in 11 normal-hearing subjects. As a first step, loudness growth function was estimated for the two test frequencies. Then ASSR amplitude was recorded for each of the two frequencies at different stimulus intensities, each corresponding to a loudness level as given by the first part of the study. Normalized results show that the ASSR amplitude correlates well with the loudness function (R-2 = 0.81). A stepwise multiple linear regression confirmed these results with loudness explaining almost all the ASSR amplitude (loudness R 2 = 0.81,p < 0.001, f = 562 and for intensity f = 1.1, p = 0.29). The non-linearity of the ASSR amplitude for low loudness levels can be explained by both the active amplification in the cochlea and the noise in the recording. The results suggest that ASSRs can be used for "objective" loudness measurement. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Menard, Mikael; Berger-Vachon, Christian; Collet, Lionel; Thai-Van, Hung] Univ Lyon, F-69003 Lyon, France.
[Menard, Mikael; Berger-Vachon, Christian; Collet, Lionel; Thai-Van, Hung] Univ Lyon 1, F-69003 Lyon, France.
[Gallego, Stephane; Berger-Vachon, Christian; Collet, Lionel; Thai-Van, Hung] Hop Edouard Herriot, Hosp Civils Lyon, Serv Audiol & Explorat Orofaciales, F-69003 Lyon, France.
[Menard, Mikael; Berger-Vachon, Christian; Collet, Lionel; Thai-Van, Hung] CNRS, UMR 5020, F-69007 Lyon, France.
[Menard, Mikael; Berger-Vachon, Christian; Collet, Lionel; Thai-Van, Hung] Inst Fed Neurosci Lyon, F-69677 Bron, France.
[Menard, Mikael] Lab MXM, F-06224 Vallauris, France.
RP Menard, M (reprint author), Hop Edouard Herriot, CNRS, UMR 5020, Pavillon U,Pl Arsonval, F-69437 Lyon 03, France.
EM mmenard@olfac.univ-lyon
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NR 43
TC 13
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 105
EP 113
DI 10.1016/j.heares.2007.10.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000011
PM 18093768
ER
PT J
AU Dai, CF
Steyger, PS
AF Dai, Chun Fu
Steyger, Peter S.
TI A systemic gentamicin pathway across the stria vascularis
SO HEARING RESEARCH
LA English
DT Article
DE blood-labyrinth barrier; ototoxicity; aminoglycosides; cochlea; hair
cells; stria vascularis
ID INNER-EAR DYSFUNCTION; COCHLEAR HAIR-CELLS; AMINOGLYCOSIDE ANTIBIOTICS;
ETHACRYNIC-ACID; GUINEA-PIG; CELLULAR UPTAKE; SENSORY CELLS;
LATERAL-LINE; IN-VIVO; OTOTOXICITY
AB The mechanism(s) by which systemically-administered aminoglycosides enter the cochlea remain poorly understood. To elucidate which mechanisms may be involved, we co-administered different molar ratios of gentamicin and fluorescent gentamicin (GTTR) to mice in three different regimens: (1) gentamicin (150, 300 or 600 mg/kg) containing a constant 300:1 molar ratio of gentamicin:GTTR; (2) 300 mg/kg gentamicin containing a variable molar ratio of gentamicin:GTTR (150:1-600:1), or (3) an increasing dose of gentamicin (150-900 mg/kg), each dose containing 1.7 mg/kg GTTR. Three hours later, cochleae were fixed and examined by confocal microscopy. First, increasing doses of a constant molar ratio of gentamicin:GTTR, resulted in increasing intensities of GTTR fluorescence in hair cells and strial tissues. Second, a fixed gentamicin dose with increasing molar dilution of GTTR led to decreasing GTTR fluorescence in hair cells and strial tissues. Third, a fixed GTTR dose with increasing molar dilution by gentamicin led to decreased GTTR uptake in hair cells and marginal cells, but not intra-strial tissues and capillaries. Thus, only hair cell and marginal cell uptake of GTTR is competitively inhibited by gentamicin, suggesting that a regulatable barrier for gentamicin entry into endolymph exists at the interface between marginal cells, the intra-strial space and intermediate cells. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Dai, Chun Fu; Steyger, Peter S.] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
[Dai, Chun Fu] Fudan Univ, Eye Ear Nose & Throat Hosp, Dept Otolaryngol, Shanghai 200031, Peoples R China.
RP Steyger, PS (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM steygerp@ohsu.edu
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NR 46
TC 25
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 114
EP 124
DI 10.1016/j.heares.2007.10.010
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000012
PM 18082985
ER
PT J
AU Ozimek, E
Konleczny, J
Sone, T
AF Ozimek, Edward
Konleczny, Jacek
Sone, Toshio
TI Binaural perception of the modulation depth of AM signals
SO HEARING RESEARCH
LA English
DT Article
DE binaural perception; AM signals; loudness summation
ID INTENSITY DISCRIMINATION; SPEECH-INTELLIGIBILITY; TEMPORAL INTEGRATION;
AMPLITUDE-MODULATION; LOUDNESS FUNCTION; PURE-TONES; SUMMATION;
RESPONSES; SOUNDS; LEVEL
AB The purpose of this study was to determine the binaurally perceived modulation depth (m) of the low rate amplitude modulated (AM) signals, under conditions of their dichotic presentation, i.e., when the AM signals presented to the left and the right ear had different modulation depths. The modulation depth was determined as a point of subjective equality between the sensations of the modulation depth of AM signals presented to the left and right ear, using a one-up, one-down adaptive procedure. Measurements were made for the carrier frequencies (f(c)) of 250, 1000, and 4000 Hz, and the modulation frequency (f(m)) of 4 Hz. Experimental data showed that, for sufficiently small interaural difference in modulation depth (Delta m), the perceived modulation approximated the mean of the modulation depths presented to the left and the right ear. However, for moderate and large Delta m, the binaurally perceived modulation was lower than the mean of m(l) and m(r) and the steepness of the function m =f(Delta m) gradually decreased with an increase of Delta m. Results of the calculation of the binaurally perceived modulation depth, obtained on the assumption of binaural loudness summation, were found to be consistent within the limit of standard deviation, with the experimental data for relatively wide range of Delta m. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Ozimek, Edward; Konleczny, Jacek] Adam Mickiewicz Univ Poznan, Inst Acoust, PL-61614 Poznan, Poland.
[Sone, Toshio] Akita Prefectural Univ, Fac Elect & Informat Syst, Tsuchiya, Honjo 0150055, Japan.
RP Ozimek, E (reprint author), Adam Mickiewicz Univ Poznan, Inst Acoust, Umultowska 85, PL-61614 Poznan, Poland.
EM ozimaku@amu.edu.pl; komaku@amu.edu.pl; tsoiie@akita-pu.ae.jp
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NR 49
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 125
EP 133
DI 10.1016/j.heares.2007.10.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000013
PM 18082983
ER
PT J
AU Ebert, CS
Blanks, DA
Patel, MR
Coffey, CS
Marshall, AF
Fitzpatrick, DC
AF Ebert, Charles S., Jr.
Blanks, Deldra A.
Patel, Mihir R.
Coffey, Charles S.
Marshall, Allen F.
Fitzpatrick, Douglas C.
TI Behavioral sensitivity to interaural time differences in the rabbit
SO HEARING RESEARCH
LA English
DT Article
DE sound localization; animal psychoacoustics; neural discrimination
ID SUPERIOR OLIVARY COMPLEX; INFERIOR COLLICULUS; SOUND-LOCALIZATION;
UNANESTHETIZED RABBIT; AUDITORY-CORTEX; PSYCHOMETRIC FUNCTION; CHANGING
FREQUENCY; JEFFRESS MODEL; HEARING-LOSS; SPATIAL CUE
AB An important cue for sound localization and separation of signals from noise is the interaural time difference (ITD). Humans are able to localize sounds within 1-2 degrees and can detect very small changes in the ITD (10-20 mu s). In contrast, many animals localize sounds with less precision than humans. Rabbits, for example, have sound localization thresholds of similar to 22 degrees. There is only limited information about behavioral ITD discrimination in animals with poor sound localization acuity that are typically used for the neural recordings. For this study, we measured behavioral discrimination of ITDs in the rabbit for a range of reference ITDs from 0 to +/- 300 mu s. The behavioral task was conditioned avoidance and the stimulus was band-limited noise (500-1500 Hz). Across animals, the average discrimination threshold was 50-60 mu s for reference ITDs of 0 to +/-200 mu s. There was no trend in the thresholds across this range of reference ITDs. For a reference ITD of +/-300 mu s, which is near the limit of the physiological window defined by the head width in this species, the discrimination threshold increased to similar to 100 mu s. The ITD discrimination in rabbits less acute than in cats, which have a similar head size. This result supports the suggestion that ITD discrimination, like sound localization [see Heffner, 1997. Acta Otolaryngol. 532 (Suppl.), 46-53] is determined by factors other than head size. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Ebert, Charles S., Jr.; Blanks, Deldra A.; Patel, Mihir R.; Coffey, Charles S.; Marshall, Allen F.; Fitzpatrick, Douglas C.] Univ N Carolina, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
RP Fitzpatrick, DC (reprint author), Univ N Carolina, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, CB 7070, Chapel Hill, NC 27599 USA.
EM dcf@med.unc.edu
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NR 53
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 134
EP 142
DI 10.1016/j.heares.2007.11.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000014
PM 18093767
ER
PT J
AU Chatterjee, M
Peng, SC
AF Chatterjee, Monita
Peng, Shu-Chen
TI Processing F0 with cochlear implants: Modulation frequency
discrimination and speech intonation recognition
SO HEARING RESEARCH
LA English
DT Article
DE modulation frequency discrimination; speech intonation; prosody;
cochlear implants; voice pitch
ID CURRENT PULSE TRAINS; TEMPORAL CUES; VOWEL IDENTIFICATION; PITCH
PERCEPTION; ENVELOPE; LISTENERS; STIMULATION; SIMULATIONS; HEARING;
STRESS
AB Fundamental frequency (F0) processing by cochlear implant (CI) listeners was measured using a psychophysical task and a speech intonation recognition task. Listeners' Weber fractions for modulation frequency discrimination were measured using an adaptive, 3-interval, forced-choice paradigm: stimuli were presented through a custom research interface. In the speech intonation recognition task, listeners were asked to indicate whether resynthesized bisyllabic words, when presented in the free field through the listeners' everyday speech processor, were question-like or statement-like. The resynthesized tokens were systematically manipulated to have different initial-F0s to represent male vs. female voices, and different F0 contours (i.e. falling, flat, and rising) Although the CI listeners showed considerable variation in performance on both tasks, significant correlations were observed between the CI listeners' sensitivity to modulation frequency in the psychophysical task and their performance in intonation recognition. Consistent with their greater reliance on temporal cues, the CI listeners' performance in the intonation recognition task was significantly poorer with the higher initial-F0 stimuli than with the lower initial-F0 stimuli. Similar results were obtained with normal hearing listeners attending to noiseband-vocoded CI simulations with reduced spectral resolution. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Chatterjee, Monita; Peng, Shu-Chen] Univ Maryland, Dept Speech & Hearing Sci, Cochlear Implants & Psychophys Lab, College Pk, MD 20742 USA.
RP Chatterjee, M (reprint author), Univ Maryland, Dept Speech & Hearing Sci, Cochlear Implants & Psychophys Lab, 0100 LeFrak Hall, College Pk, MD 20742 USA.
EM mchatterjee@hesp.umd.edu
RI Imhof, Margarete/F-8471-2011
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NR 47
TC 45
Z9 46
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2008
VL 235
IS 1-2
BP 143
EP 156
DI 10.1016/j.heares.2007.11.004
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 263WA
UT WOS:000253246000015
PM 18093766
ER
PT J
AU Heffner, RS
Koay, G
Heffner, HE
AF Heffner, R. S.
Koay, G.
Heffner, H. E.
TI Sound-localization acuity and its relation to vision in large and small
fruit-eating bats: I. Echolocating species, Phyllostomus hastatus and
Carollia perspicillata
SO HEARING RESEARCH
LA English
DT Article
DE sound localization; vision; echolocation
ID SUPERIOR OLIVARY COMPLEX; LEAF-NOSED BATS; BINAURAL CUES; VISUAL-ACUITY;
EPTESICUS-FUSCUS; GANGLION-CELLS; HEARING; ORIENTATION; CAT; CHIROPTERA
AB Passive sound-localization acuity for 100-ms noise bursts was determined behaviorally for two species of bats: Phyllostomus hastatus, a large bat that eats fruit and vertebrates, and Carollia perspicillata, a small species that eats fruit and nectar. The mean minimum audible angle for two P. hastatus was 9 degrees, and that for two C perspicillata was 14.8 degrees. This places their passive sound-localization acuity near the middle of the range for mammals. Sound localization varies widely among mammals and the best predictor of a species' acuity remains the width of the field of best vision (r =.89, p < .0001). The five echolocating bats that have been tested do not deviate from this relationship suggesting that despite their specialization for echolocation, the use of hearing to direct the eyes to the source of a sound still serves as an important selective factor for sound localization. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Heffner, R. S.; Koay, G.; Heffner, H. E.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
RP Heffner, RS (reprint author), Univ Toledo, Dept Psychol, 2801 W Bancroft St, Toledo, OH 43606 USA.
EM Rickye.Heffner@utoledo.edu
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NR 46
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2007
VL 234
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2007.06.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 244WK
UT WOS:000251895800001
PM 17630232
ER
PT J
AU Noben-Trauth, K
Neely, H
Brady, RO
AF Noben-Trauth, Konrad
Neely, Harold
Brady, Roscoe O.
TI Normal hearing in alpha-galactosidase A-deficient mice, the mouse model
for Fabry disease
SO HEARING RESEARCH
LA English
DT Article
DE alpha-galactosidase A; Fabry disease; hearing
ID STRAINS
AB Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the alpha-galactosidase gene (Gla). Loss of Gla activity leads to the abnormal accumulation of glycosphingolipids in lysosomes of predominantly vascular endothelial cells. Clinically the disorder presents with angiokeratomas, clouding of the cornea, and renal, cardiac, and cerebrovascular complications. In addition, there is an increased incidence of sensorineural hearing loss in Fabry patients. In this study, we investigated the loss of alpha-galactosidase A activity on hearing function in Gla-deficient mice (Gla(tm1Kul)). Gla mRNA was readily detected in the cochlea of 2- and 12-month old C57BL/6J and C3HeB/FeJ mice. The targeted allele was introgressed to the normal hearing C3HeB/FeJ strain to eliminate confounding genetic background effects. Auditory brain stem responses (ABR) to click, 8-, 16-, and 32 kHz stimuli measured at regular intervals from animals at the N4 backcross generation and from N4F1 hybrids demonstrated normal hearing in hemizygous and homozygous mutant mice up to 76 weeks of age. By histological criteria, the cyto-architecture of the mutant cochlea showed a normal appearance. The data demonstrate that in the mouse the loss of alpha-galactosidase A activity is genetically or biochemically buffered and not sufficient per se to cause an appreciable degree of hearing impairment. Published by Elsevier B.V.
C1 [Noben-Trauth, Konrad; Neely, Harold] Natl Inst Deafness & Other Commun Disorders, Neurogenet Sect, Mol Biol Lab, NIH, Rockville, MD 20855 USA.
[Brady, Roscoe O.] NINDS, Dev & Metab Neurol Branch, NIH, Bethesda, MD 20892 USA.
RP Noben-Trauth, K (reprint author), Natl Inst Deafness & Other Commun Disorders, Neurogenet Sect, Mol Biol Lab, NIH, 5 Res Court, Rockville, MD 20855 USA.
EM nobentk@nidcd.nih.gov
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NR 18
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2007
VL 234
IS 1-2
BP 10
EP 14
DI 10.1016/j.heares.2007.08.009
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 244WK
UT WOS:000251895800002
PM 17933476
ER
PT J
AU DiGiovanni, JJ
Nair, P
AF DiGiovanni, Jeffrey J.
Nair, Padmaja
TI Response growth using a low-frequency suppressor
SO HEARING RESEARCH
LA English
DT Article
DE suppression; psychoacoustics; psychophysics; basilar membrane; forward
masking; masking
ID 2-TONE SUPPRESSION; AUDITORY-NERVE
AB Numerous psychophysical studies on two-tone suppression have been carried out. More recently, researchers have attempted to relate the magnitude of suppression to the level of suppressee. [Wojtczak, M., Viemeister, N.F., 2005. Psychophysical response growth under suppression. In: Pressnitzer, D., de Cheveigne, A., McAdams, S., Collet, L. (Eds.), Auditory Signal Processing: Physiology, Psychoaccoustics, and Models. Springer, New York, pp. 67-74] demonstrated that the magnitude of suppression for a higher-frequency, fixed-level suppressor decreases with increasing level of the suppressee. This suggests a linearization of the basilar membrane response in presence of a high-frequency suppressor. The present study expands these results to a low-frequency suppressor of varying intensity levels. Detection of a 10-ms, 4.0-kHz probe was measured under different forward-masking conditions: one with a 200-ms, 4.0-kHz masker (suppressee) presented with no suppressor and another with the same masker paired with a 2.2-kHz, 200-ms suppressor. The 4.0-kHz masker level was varied adaptively and a range of probe levels was used to measure the growth of suppression. Results indicate that (1) the magnitude of suppression increases with increasing suppressor level and (2) generally, the probe level was not related to the magnitude of suppression. (C) 2007 Elsevier B.V. All rights reserved.
C1 [DiGiovanni, Jeffrey J.; Nair, Padmaja] Ohio Univ, Auditory Psychophys & Signal Proc Lab, Sch Hearing Speech & Language Sci, Athens, OH 45701 USA.
RP DiGiovanni, JJ (reprint author), Ohio Univ, Auditory Psychophys & Signal Proc Lab, Sch Hearing Speech & Language Sci, W151A Grover Ctr, Athens, OH 45701 USA.
EM digiovan@ohio.edu
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Wojtczak M, 2005, AUDITORY SIGNAL PROCESSINGP: PHYSIOLOGY, PSYCHOACOUSTICS, AND MODELS, P67, DOI 10.1007/0-387-27045-0_9
NR 8
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2007
VL 234
IS 1-2
BP 15
EP 20
DI 10.1016/j.heares.2007.08.008
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 244WK
UT WOS:000251895800003
PM 17923348
ER
PT J
AU Longo-Guess, C
Gagnon, LH
Bergstrom, DE
Johnson, KR
AF Longo-Guess, Chantal
Gagnon, Leona H.
Bergstrom, David E.
Johnson, Kenneth R.
TI A missense mutation in the conserved C2B domain of otoferlin causes
deafness in a new mouse model of DFNB9
SO HEARING RESEARCH
LA English
DT Article
DE otoferlin; mutation; deafness; mouse; ABR; VsEP
ID RECESSIVE AUDITORY NEUROPATHY; GRAVITY RECEPTOR FUNCTION; HAIR-CELLS;
ENCODING OTOFERLIN; HEARING-LOSS; MUTANT MICE; OTOF; STRAINS; GENE; FORM
AB Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypic characterization of a new ENU-induced missense mutation of the mouse otoferlin gene designated Otof(deaf5Jcs). The mutation is a single T to A base substitution in exon 10 of Otof that causes a non-conservative amino acid change of isoleucine to asparagine in the C2B domain of the protein. Although strong immunoreactivity with an otoferlin-specific antibody was detected in cochlear hair cells of wildtype mice, no expression was detected in mutant mice, indicating that the missense mutation has a severe effect on the stability of the protein and potentially its localization. Auditory brainstem response (ABR) analysis demonstrated that mice homozygous for the missense mutation are profoundly deaf, consistent with an essential role for otoferlin in inner hair cell neurotransmission. Vestibular-evoked potentials (VsEPs) of mutant mice, however, were equivalent to those of wildtype mice, indicating that otoferlin is unnecessary for vestibular function even though it is highly expressed in both vestibular and cochlear hair cells. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Longo-Guess, Chantal; Gagnon, Leona H.; Bergstrom, David E.; Johnson, Kenneth R.] Jackson Lab, Bar Harbor, ME 04609 USA.
RP Johnson, KR (reprint author), Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
EM ken.johnson@jax.org
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NR 26
TC 27
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2007
VL 234
IS 1-2
BP 21
EP 28
DI 10.1016/j.heares.2007.09.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 244WK
UT WOS:000251895800004
PM 17967520
ER
PT J
AU Wang, X
Jia, SP
Currall, B
Yang, SM
He, DZZ
AF Wang, Xiang
Jia, Shuping
Currall, Benjamin
Yang, Shiming
He, David Z. Z.
TI Streptomycin and gentamicin have no immediate effect on outer hair cell
electromotility
SO HEARING RESEARCH
LA English
DT Article
DE ototoxicity; outer hair cells; somatic motility; gerbils
ID RIBOSOMAL-RNA GENE; AMINOGLYCOSIDE ANTIBIOTICS; BULLFROGS SACCULUS;
VOLTAGE SENSOR; BUNDLE MOTION; MOTOR PROTEIN; MOTILITY; CHANNELS;
DEAFNESS; PRESTIN
AB The cochlear outer hair cell (OHC), which plays a crucial role in mammalian hearing through its unique voltage-dependent motility, has been established as a primary target of the ototoxicity of aminoglycoside antibiotics. These polycationic drugs are also known to block a wide variety of ion channels, purinergic ionotropic channels, and nicotinic ACh receptors in hair cells in vitro. The OHC motor protein, prestin, is a voltage-sensitive transmembrane protein containing several negatively charged residues on both intra- and extracellular surface. The acidic sites may be susceptible to polycationic-charged aminoglycoside binding, which may result in disruption of motility. We attempted to examine whether aminoglycosides such as streptomycin and gentamicin could affect OHC motility and its electrical signature, the nonlinear capacitance (NLC) in adult gerbil OHCs. Somatic motility and NLC were measured under the whole-cell voltage-clamp mode. Streptomycin and gentamicin were applied extracellularly or intracellularly. Results show that streptomycin and gentamicin did not change either the magnitude of motility or the NLC. Theses results suggest that, although streptomycin and gentamicin can block mechanotransduction channels as well as ACh receptors in hair cells, they have no direct affect on OHC somatic motility. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Wang, Xiang; Jia, Shuping; Currall, Benjamin; He, David Z. Z.] Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA.
[Yang, Shiming] Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China.
RP He, DZZ (reprint author), Creighton Univ, Sch Med, Dept Biomed Sci, 2500 Calif Plaza, Omaha, NE 68178 USA.
EM hed@creighton.edu
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NR 40
TC 4
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2007
VL 234
IS 1-2
BP 52
EP 58
DI 10.1016/j.heares.2007.09.001
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 244WK
UT WOS:000251895800006
PM 17964097
ER
PT J
AU Martin, GK
Vazquez, AE
Jimenez, AM
Stagner, BB
Howard, MA
Lonsbury-Martin, BL
AF Martin, Glen K.
Vazquez, Ana E.
Jimenez, Ana M.
Stagner, Barden B.
Howard, MacKenzie A.
Lonsbury-Martin, Brenda L.
TI Comparison of distortion product otoacoustic emissions in 28 inbred
strains of mice
SO HEARING RESEARCH
LA English
DT Article
DE inbred mouse strains; distortion product otoacoustic emissions; cochlea;
outer hair cell; age-related hearing loss; mouse hearing screening
ID HEARING-LOSS; COCHLEAR FUNCTION; NOISE EXPOSURE; CBA/J MOUSE; AHL;
MECHANICS; GENETICS; MODEL; MAP
AB Cochlear function was evaluated in a longitudinal study of 28 inbred strains of mice at 3 and 5 mo of age using measures of distortion product otoacoustic emissions (DPOAEs) in response to a federal initiative to develop rapid mouse phenotyping methodologies. DP-grams at f(2) frequencies ranging from 6.3 to 54.2 kHz were obtained in about 3 min/ear by eliciting 2f(1) - f(2) DPOAEs in 0.1-octave steps of f(2) with primary tones at L-1 = L-2 = 55, 65, and 75 dB SPL. CBA/CaJ mice exhibited average levels of similar to 26 dB SPL and this strain was selected as the normal reference strain against which the others were compared. Based upon the configurations of their DP-grams, the 28 mouse strains could be categorized into four distinct groups. That is, nine of the strains including the CBA were designated as the CBA-like group because these mice displayed robust DPOAE levels across frequency. In contrast, the remaining three groups all exhibited irregular DP-gram patterns. Specifically, eight of the remaining 19 strains showed a progressive high- to low-frequency reduction in DPOAE levels that was typical of age-related hearing loss (AHL) associated with mouse strains homozygous for the ahl allele and were labeled as AHL-like strains. Seven strains demonstrating relatively even patterns of reduced DPOAE levels across the frequency-test range were designated as Flat-loss strains. Finally, the remaining four strains exhibited no measurable DPOAEs at either 3 or 5 mo of age and thus were classified as Absent strains. Extending the f(2) test frequencies up to similar to 54 kHz led to the detection of very early-onset reductions in cochlear function in non-CBA-like groups so that all strains could be categorized by 3 mo of age. Predictably, the AHL-like strains showed more pronounced DPOAE losses at 5 mo than at 3 mo. A similar deterioration in DPOAE levels was not apparent for the Flat-loss strains. Both the AHL-like and Flat-loss strains showed considerably more variability in DPOAE levels than did the CBA-like strains. Together, these findings indicate that DP-grams adequately reveal both frequency-specific loss patterns and details of inbred strain variability. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Martin, Glen K.; Stagner, Barden B.; Lonsbury-Martin, Brenda L.] Jerry L Pettis Mem Vet Adm Med Ctr, Res Serv, Loma Linda, CA 92357 USA.
[Vazquez, Ana E.] Loma Linda Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Loma Linda, CA USA.
[Vazquez, Ana E.] Univ Calif Davis, Dept Otolaryngol, Davis, CA 95616 USA.
[Vazquez, Ana E.] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
[Jimenez, Ana M.] Nova SE Univ, Coll Med Sci, Hlth Profess Div, Ft Lauderdale, FL 33314 USA.
[Howard, MacKenzie A.] Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
RP Martin, GK (reprint author), Jerry L Pettis Mem Vet Adm Med Ctr, Res Serv, 11201 Benton St, Loma Linda, CA 92357 USA.
EM glen.martin2@va.gov
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NR 29
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2007
VL 234
IS 1-2
BP 59
EP 72
DI 10.1016/j.heares.2007.09.002
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 244WK
UT WOS:000251895800007
PM 17997239
ER
PT J
AU Thai-Van, H
Micheyl, C
Norena, A
Veuillet, E
Gabriel, D
Collet, L
AF Thai-Van, Hung
Micheyl, Christophe
Norena, Arnaud
Veuillet, Evelyne
Gabriel, Damien
Collet, Lionel
TI Enhanced frequency discrimination in hearing-impaired individuals: A
review of perceptual correlates of central neural plasticity induced by
cochlear damage
SO HEARING RESEARCH
LA English
DT Article
DE auditory plasticity; hearing loss; frequency discrimination; cochlear
dead regions; hearing aids
ID PRIMARY AUDITORY-CORTEX; ENRICHED ACOUSTIC ENVIRONMENT; DEAD REGIONS;
PITCH PERCEPTION; BRAILLE READERS; ADULT CATS; CORTICAL REPRESENTATION;
TONOTOPIC ORGANIZATION; LOSS CUTOFF; LESIONS
AB Cochlear damages have been shown to induce changes in tonotopic maps in the central auditory system of animals; neurons deprived from peripheral inputs start to respond to stimuli with frequencies close to the cutoff frequency (Fc) or "edge" of the hearing loss, which then become over-represented at the neural level. Here, we review findings, which reveal a possible psychophysical correlate of such central over-representation in human listeners with sensorineural hearing loss. These findings concur to demonstrate a local improvement in difference limens for frequency (DLFs) at or near Fc. This effect has now been observed in several studies and subjects with varied audiometric characteristics, including high- and low-frequency, and symmetric and asymmetric hearing losses. The presence of cochlear dead region or a steeply sloping hearing loss appear as a necessary condition for its occurrence. The effect cannot be explained simply by more prominent loudness cues or spontaneous otoacoustic emissions (SOAEs) near the audiogram edge. Overall, the data are consistent with local changes in pitch discrimination performance near the hearing-loss cutoff frequency being a result of the neural over-representation of that frequency region in the central auditory system. Further work is needed to confirm this hypothesis, and investigate other possible perceptual correlates of injury-related cortical plasticity in both humans and animals. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Lyon 1, F-69003 Lyon, France.
CNRS, UMR Neurosci Sensorielles Comportement Cognit 502, F-69007 Lyon, France.
Hop Edouard Herriot, Serv Audiol & Explorat Orofaciales, Hosp Civils Lyon, F-69003 Lyon, France.
Inst Federat Neurosci Lyon, F-69677 Lyon, France.
Univ Minnesota, Dept Psychol, Auditory Percept & Cognit Grp, Minneapolis, MN 55455 USA.
Univ Aix Marseille 1, F-13331 Marseille 03, France.
CNRS, UMR Neurobiol Integrat & Adaptat 6149, F-13331 Marseille 03, France.
RP Thai-Van, H (reprint author), CHU Edouard Herriot, Audiol Grp, CNRS, Serv Audiol & Explorat Orofaciales,UMR 5020, Pavillon U,Pl Arsonval, F-69437 Lyon 03, France.
EM hung.thai-van@chu-lyon.fr
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NR 55
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 14
EP 22
DI 10.1016/j.heares.2007.06.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000002
PM 17658232
ER
PT J
AU Chen, W
Cacclabue-Rivolta, DI
Moore, HD
Rivolta, MN
AF Chen, Wei
Cacclabue-Rivolta, Daniela I.
Moore, Harry D.
Rivolta, Marcelo N.
TI The human fetal cochlea can be a source for auditory progenitors/stem
cells isolation
SO HEARING RESEARCH
LA English
DT Article
DE human fetal cochlea; human auditory stem cells; regeneration
ID MAMMALIAN INNER-EAR; PLURIPOTENT STEM-CELLS; HAIR-CELLS; RETINOIC ACID;
IN-VITRO; GROWTH-FACTOR; HEARING-LOSS; GUINEA-PIG; MOUSE;
DIFFERENTIATION
AB The development of new stem cell-based technologies is creating new hopes in regenerative medicine. Hearing-impaired individuals should benefit greatly from the development of a cell-based regenerative strategy to treat deafness. An important achievement would be to develop a human-based system that could bring the advances made in animal models closer to clinical application. In this work, we have explored the suitability of the developing fetal cochlea to be used as a source for the extraction of auditory progenitor/stem cells. We have established cultures that express critical markers such as NESTIN, SOX2, GATA3 and PAX2. These cultures can be expanded in vitro for several months and differentiating markers such as ATOH1/HATH1 and POU4F3/BRN3C can be induced by manipulating the culture conditions using specific growth factors such as bFGF, EGF and retinoic acid. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Sheffield, Dept Biomed Sci, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England.
RP Rivolta, MN (reprint author), Univ Sheffield, Dept Biomed Sci, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England.
EM m.n.rivolta@sheffield.ac.uk
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NR 45
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 23
EP 29
DI 10.1016/j.heares.2007.06.006
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000003
PM 17646067
ER
PT J
AU Traboulsi, R
Avan, P
AF Traboulsi, Raghida
Avan, Paul
TI Transmission of infrasonic pressure waves from cerebrospinal to
intralabyrinthine fluids through the human cochlear aqueduct:
Non-invasive measurements with otoacoustic emissions
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; distortion; intralabyrinthine pressure;
respiration; cochlear aqueduct; cerebrospinal fluid
ID INTRACRANIAL-PRESSURE; GUINEA-PIG; DEHISCENCE; FREQUENCY; DYNAMICS;
STAPES
AB The cochlear aqueduct connecting intralabyrinthine and cerebrospinal fluids (CSF) acts as a low-pass filter that should be able to transmit infrasonic pressure waves from CSF to cochlea. Recent experiments have shown that otoacoustic emissions generated at 1 kHz respond to pressure-related stapes impedance changes with a change in phase relative to the generator tones, and provide a non-invasive means of assessing intracochlear pressure changes. In order to characterize the transmission to the cochlea of CSF pressure waves due to respiration, the distortion-product otoacoustic emissions (DPOAE) of 12 subjects were continuously monitored around I kHz at a rate of 6.25 epochs/s, and their phase relative to the stimulus tones was extracted. The subjects breathed normally, in different postures, while thoracic movements were recorded so as to monitor respiration. A correlate of respiration was found in the time variation of DPOAE phase, with an estimated mean amplitude of 10 degrees, i.e. 60 mm water, suggesting little attenuation across the aqueduct. Its phase lag, relative to thoracic movements varied between 0 degrees and -270 degrees. When fed into a two-compartment model of CSF and labyrinthine spaces, these results suggest that respiration rate at rest is just above the resonance frequency of the CSF compartment, and just below the corner frequency of the cochlear-aqueduct low-pass filter, in line with previous estimates from temporal bone and intracranial measurements. The fact that infrasonic CSF waves can be monitored through the cochlea opens diagnostic possibilities in neurology. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Auvergne, Sch Med, Lab Sensory Biophys, F-63000 Clermont Ferrand, France.
RP Traboulsi, R (reprint author), Univ Auvergne, Sch Med, Lab Sensory Biophys, 28 Pl Henri Dunant, F-63000 Clermont Ferrand, France.
EM rtraboulsi@yahoo.fr; paul.avan@u-clermontl.fr
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NR 26
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 30
EP 39
DI 10.1016/j.heares.2007.06.012
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000004
PM 17716844
ER
PT J
AU Spicer, SS
Qu, C
Smythe, N
Schulte, BA
AF Spicer, Samuel S.
Qu, Chunyan
Smythe, Nancy
Schulte, Bradley A.
TI Mitochondria-activated cisternae generate the cell specific vesicles in
auditory hair cells
SO HEARING RESEARCH
LA English
DT Article
DE vesiculogenesis; hearing; cochlea; granular reticulum; ATPase;
mitochondria
ID LIPID ASYMMETRY; MEMBRANE; GERBIL
AB A dense population of vesicles largely fills the infranuclear compartment of gerbil inner hair cells (IHCs). Although the nature of the cargo in these vesicles has not been determined, the absence of a Golgi apparatus from the IHC's basal compartment suggests that the vesicles lack the glycosylated protein that Golgi cisternae would provide. Instead, they likely possess neurotransmitter and function as synaptic vesicles. The morphologic mechanism for generating the vesicles also remains unexplained. Ultrastructural examination revealed a few discrete clusters of mitochondria in the IHC's basal compartment. The clustered mitochondria made contact either with intermingling single cisternae or with one end of an unique set of polarized parallel cisternae. Both of these cisternal forms belong to a novel, mitochondria-activated category of cisternae which transforms into aligned segments where contactin mitochondria. Mitochondria-activated cisternae also envelope the vesicles in Hensen bodies of outer hair cells (OHCs). Coexistence of the mitochondria-activated cisternae with a specialized population of cytoplasmic vesicles in both IHCs and OHCs implicated this type of cisterna in synthesis of the cell specific vesicles. Assumedly, the mitochondria-activated cisternae possess an ATPase of the Class IV type. This class of enzymes, also designated flippases, translocates aminophospholipid from the outer to inner leaflet of the lipid bilayer and appears thereby to induce a lipid asymmetry which leads to cisternal segmentation and then vesiculation. In support of such an interpretation, RT-PCR analysis demonstrated the presence of Class IV ATPase in the Organ of Corti. (C) 2007 Elsevier B.V. All Fights reserved.
C1 Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Spicer, SS (reprint author), Med Univ S Carolina, Dept Pathol & Lab Med, 165 Ashley Ave,Suite 309,POB 250908, Charleston, SC 29425 USA.
EM schulteb@musc.edu
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NR 18
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 40
EP 45
DI 10.1016/j.heares.2007.07.005
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000005
PM 17825509
ER
PT J
AU Ou, HC
Raible, DW
Rubel, EW
AF Ou, Henry C.
Raible, David W.
Rubel, Edwin W.
TI Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line
SO HEARING RESEARCH
LA English
DT Article
DE hair cell; cisplatin; zebrafish; ototoxicity; cell death; lateral line
ID INDUCED OTOTOXICITY; D-METHIONINE; IN-VITRO; UNCHANGED CISPLATIN;
ANIMAL-MODEL; GUINEA-PIGS; DEATH; PHARMACOKINETICS; CARBOPLATIN;
GENTAMICIN
AB We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death occurred Much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was established that cisplatin causes hair cell loss in the lateral line in a dose-dependent fashion. The kinetics of hair cell loss during exposure to different concentrations of cisplatin was also assessed and it was found that the onset of hair cell loss correlated with the accumulated dose of cisplatin. These data demonstrate the feasibility and repeatability of cisplatin damage protocols in the zebrafish lateral line and set the stage for future evaluations of modulation of cisplatin-induced hair cell death. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA.
Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA.
RP Ou, HC (reprint author), Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA.
EM henrylou@u.washington.edu
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NR 38
TC 58
Z9 60
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 46
EP 53
DI 10.1016/j.heares.2007.07.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000006
PM 17709218
ER
PT J
AU Dammeijer, PFM
Van Dijk, P
Chenault, MN
Manni, JJ
Van Maineren, H
AF Dammeijer, Patrick F. M.
Van Dijk, Paul
Chenault, Michelene N.
Manni, Johannes J.
Van Maineren, Henk
TI Stapedius muscle fibre characterization in the noise exposed and
auditory deprived rat
SO HEARING RESEARCH
LA English
DT Article
DE stapedius; myosin ATPase liability; myosin heavy chain; noise exposure;
auditory deprivation; rat
ID MYOSIN HEAVY-CHAINS; SKELETAL-MUSCLE; FAST-TWITCH; SOUND-TRANSMISSION;
INNER-EAR; REFLEX; EXPRESSION; ATPASE; RESPONSES; IDENTIFICATION
AB In skeletal muscle, interventions that unload the muscle cause slow-to-fast myosin heavy chain (MHC) conversions, whereas fast-to-slow conversions are seen when the muscles are engaged in resistance training and endurance exercise. The stapedius muscle (SM) is reported to prevent cochlear damage by noise. This theory may be supported by showing comparable changes of muscle fibre composition when ears are exposed to longstanding noise (SM training). Comparable changes after sound deprivation (SM unloading) would suggest that the SM needs a certain degree of daily activity evoked by environmental sound to sustain its normal composition.
We investigated the difference in myosin composition of SM fibres from rats exposed to noise, from auditory deprived rats and from rats exposed to low level ambient noise (control group). Consecutive complete SM cross-sections were processed by enzymehistochemistry to determine acid/alkali lability of myofibrillar adenosine triphosphatase (mATPase) and by immunohistochemistry using MHC antibodies. Fibres were assigned to mATPase type I, IIA, IIX or 'Miscellaneous' categories. Per mATPase category, the fibres were attributed to groups with specific MHC isoform compositions. Auditory deprivation lasting nine weeks was accomplished by closure of the external meatus at the age of three weeks. A slow-to-fast shift was seen in these rats when compared to the control group.
The noise exposed group was exposed to 65-90 dB sound pressure level during a period lasting nine weeks from the age of three weeks onwards. A shift from an overwhelming presence of type mATPase IIX, as seen in the control group, to type mATPase IIA occurred in the noise exposed group. Also, more MHC IIA/IIX hybrid fibres were found in the mATPase IIX category. An adaptive response to the acoustic environment in the characteristics of the fibres of the SM, comparable to the response in skeletal muscles on unloading and training activity, can be ascertained. This supports the theory that the SM plays an active role in modulating external acoustic energy on entry to the cochlea. Our results are also in favour of another postulated function of the SM, the unmasking of high-frequency signals in low-frequency background noise. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Hosp Maastricht, Dept Otolaryngol Head & Neck Surg, NL-6202 AZ Maastricht, Netherlands.
Univ Maastricht, Dept Anat Embryol, NL-6200 MD Maastricht, Netherlands.
Dept Methodol & Stat, NL-6200 MD Maastricht, Netherlands.
RP Dammeijer, PFM (reprint author), VieCuri Teaching Hosp, Dept Otolaryngol Head & Neck Surg, POB 1926, NL-5900 BX Venlo, Netherlands.
EM pdammeijer@viecuri.nl; p.vandijk@ae.unimaas.ni; mche@skno.azm.nl;
jman@skno.azm.nl; h.vanmameren@ae.unimaas.nl
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NR 54
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 54
EP 66
DI 10.1016/j.lieares.2007.07.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000007
PM 17890031
ER
PT J
AU Hensel, J
Scholz, G
Hurttig, U
Mrowinski, D
Janssen, T
AF Hensel, Johannes
Scholz, Guenther
Hurttig, Ulrike
Mrowinski, Dieter
Janssen, Thomas
TI Impact of infrasound on the human cochlea
SO HEARING RESEARCH
LA English
DT Article
DE infrasound biasing; modulated DPOAEs; human cochlear mechanics
ID PRODUCT OTOACOUSTIC EMISSIONS; LOW-FREQUENCY MODULATION; MASKING-PERIOD
PATTERNS; AMPLIFIER; LEVEL; NOISE; DIAGNOSTICS; DEPENDENCE; 2F(1)-F(2);
RESPONSES
AB Low-frequency tones were reported to modulate the amplitude of distortion product otoacoustic emissions (DPOAEs) indicating periodic changes of the operating point of the cochlear amplifier. The present study investigates potential differences between infrasound and low-frequency sounds in their ability to modulate human DPOAEs. DPOAEs were recorded in 12 normally hearing subjects in the presence of a biasing tone with f(B) = 6 Hz and a level L-B = 130 dB SPL. Primary frequencies were fixed at f(1) = 1.6 and f(2) = 2.0 kHz with fixed levels L-1 = 51 and L-2 = 30 dB SPL. A new measure, the modulation index (MI), was devised to characterise the degree of DPOAE modulation. In subsequent measurements with biasing tones of f(B) = 12, 24 and 50 Hz, L-B was adjusted to maintain the MI as obtained individually at 6 Hz. Modulation patterns lagged with increasing f(B). The necessary L-B decreased by 12 dB/octave with increasing f(B) and ran almost parallel to the published infrasound detection threshold. No signs of an abrupt change in transmission into the cochlea were found between infra- and low-frequency sounds. The results show clearly that infrasound enters the inner ear, and can alter cochlear processing. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Med Berlin, Charite, Dept Otolaryngol, D-10117 Berlin, Germany.
Tech Univ Munich, Dept Otolaryngol, D-81675 Munich, Germany.
RP Hensel, J (reprint author), Univ Med Berlin, Charite, Dept Otolaryngol, Schumannstr 20, D-10117 Berlin, Germany.
EM johannes.hensel@charite.de; scholz@charite.de; uli_hurttig@web.de;
dieter.mrowinski@t-online.de; T.Janssen@lrz.tu-muenchen.de
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NR 32
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 67
EP 76
DI 10.1016/j.heares.2007.07.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000008
PM 17761395
ER
PT J
AU Uzun-Coruhlu, H
Curthoys, IS
Jones, AS
AF Uzun-Coruhlu, Hilal
Curthoys, Ian S.
Jones, Allan S.
TI Attachment of the utricular and saccular maculae to the temporal bone
SO HEARING RESEARCH
LA English
DT Article
DE utricular; saccular; otolith; inner ear; labyrinth; axial; x-ray;
micro-tomography
ID 3-DIMENSIONAL ANALYSIS; MORPHOLOGICAL ASPECTS; OTOLITH RESPONSES;
INNER-EAR; TOMOGRAPHY; STIMULATION
AB The present investigation concerns the true morphology of the attachment of the two otolith receptor organs the utricular and the saccular maculae in two and three dimensions. By applying a new visualization method, which utilized the application of X-ray microtomography and a method of contrast enhancement based on en-bloc staining in osmium tetroxide, we were able to overcome problems of artefact production such as tissue distortion and loss of valuable information that was present in previous studies. A series of more than 1000 axial sections were obtained for each of the specimens, which subsequently formed the basis for detailed 2D and 3D visualizations. Our interpretations of these data reveal that the saccular maculae are closely attached to the curved bony surface of the temporal bone as traditionally believed, but the utricular macula is attached to the temporal bone only at the anterior region of the macula. Crown Copyright (C) 2007 Published by Elsevier B.V. All rights reserved.
C1 Univ Sydney, Australian Key Ctr Microscopy & Microanal, Sydney, NSW 2006, Australia.
Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
RP Uzun-Coruhlu, H (reprint author), Univ Sydney, Australian Key Ctr Microscopy & Microanal, Madsen Bldg F09, Sydney, NSW 2006, Australia.
EM hilal@emu.usyd.edu.au; ianc@psych.usyd.edu.an;
allan.jones@emu.usyd.edu.au
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NR 25
TC 33
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 77
EP 85
DI 10.1016/j.heares.2007.07.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000009
PM 17919861
ER
PT J
AU De Boer, J
Brennan, S
Lineton, B
Stevens, J
Thornton, ARD
AF De Boer, Jessica
Brennan, Siobhan
Lineton, Ben
Stevens, John
Thornton, A. Roger D.
TI Click-evoked otoacoustic emissions (CEOAEs) recorded from neonates under
13 hours old using and maximum length sequence (MLS) conventional
stimulation
SO HEARING RESEARCH
LA English
DT Article
DE evoked otoacoustic emissions; neonatal screening; maximum length
sequence
ID EAR; SUPPRESSION; NONLINEARITIES; HUMANS; INFANT
AB Maximum length sequence (MLS) stimulation allows click evoked otoacoustic emissions (CEOAEs) to be averaged at very high stimulation rates. This enables a faster reduction of noise contamination of the response, and has been shown to improve the signal-to-noise ratio (SNR) of CEOAEs recorded from adult subjects. This study set out to investigate whether MLS averaging can enhance the SNR of CEOAEs recorded in newborns within the first day after birth, and so improve the pass rates for OAE screening in this period, when false alarm rates are very high. CEOAEs were recorded in a neonatal ward from 57 ears in 37 newborns ranging from 6 to 13 h old, using both conventional (50/s) and high rate (5000/s) MLS averaging. SNR values and pass rates were compared for responses obtained within equal recording times at both rates. MLS averaging produced an SNR improvement of up to 3.8 dB, with the greatest improvement found in higher frequency bands. This SNR advantage resulted in pass rate improvement between 5% and 10%, depending on pass criterion. A significant effect of age was found on both SNR and pass rate, with newborns between 6 and 10 h old showing significantly lower values than those tested between 10 and 13 h after birth, as well as a much greater improvement due to MLS averaging. The findings show that MLS averaging can reduce false alarm rates by up to 15% in very young neonates in a neonatal ward setting. (C) 2007 Published by Elsevier B.V.
C1 Royal S Hants Hosp, MRC Inst Hearing Res, Southhampton Outstn, Southampton SO14 0YG, Hants, England.
Cent Sheffield Univ Hosp, Dept Med Phys, Sheffield, S Yorkshire, England.
Univ Southampton, Inst Sound & Vibrat Res, Southampton SO9 5NH, Hants, England.
RP De Boer, J (reprint author), Royal S Hants Hosp, MRC Inst Hearing Res, Southhampton Outstn, Brintons Terrace,Mailpoint OAU, Southampton SO14 0YG, Hants, England.
EM jdb@soton.ac.uk
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NR 29
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 86
EP 96
DI 10.1016/j.heares.2007.07.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000010
PM 17850998
ER
PT J
AU Gordon, KA
Valero, J
Papsin, BC
AF Gordon, K. A.
Valero, J.
Papsin, B. C.
TI Auditory brainstem activity in children with 9-30 months of bilateral
cochlear implant use
SO HEARING RESEARCH
LA English
DT Article
DE deafness; auditory brainstem response; binaural interaction component;
binaural difference response; evoked potential; auditory development and
plasticity
ID DELAY-DEPENDENT CHANGES; CROSS-MODAL PLASTICITY; BINAURAL INTERACTION
COMPONENT; EVOKED-POTENTIALS; CLICK LATERALIZATION; CRITICAL PERIOD;
MULTIPLE-SCLEROSIS; SPEECH-PERCEPTION; MIDDLE-LATENCY; DEAF-CHILDREN
AB Bilateral cochlear implants aim to restore binaural processing along the auditory pathways in children with bilateral deafness. We assessed auditory brainstem activity evoked by single biphasic pulses delivered by an apical or basal electrode from the left, right and both cochlear implants in 13 children. Repeated measures were made over the first 9-30 months of bilateral implant use. In children with short or long periods of unilateral implant use prior to the second implantation, Wave eV of the auditory brainstem response was initially prolonged when evoked by the naive versus experienced side. These differences tended to resolve in children first implanted <3 years of age but not in children implanted at older ages with long delays between implants. Latency differences were projected to persist for longer periods in children with long delays between implants compared with children with short delays. No differences in right versus left evoked eV latency were found in 2 children receiving bilateral implants simultaneously and their response latencies decreased over time. Binaural interaction responses showed effects of stimulating electrode position (responses were more detectable when evoked by an apical than basal pair of implant electrodes), and duration of delay between implants (measured by latency delays). The trends shown here suggest a negative impact of unilateral implant use on bilateral auditory brainstem plasticity. (C) 2007 Elsevier B.V. All rights reserved.
C1 Hosp Sick Children, Cochlear Implant Lab, Toronto, ON M5G 1X8, Canada.
Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 2N2, Canada.
Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada.
RP Gordon, KA (reprint author), Hosp Sick Children, Cochlear Implant Lab, Room 6 D08,555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM karen.gordon@utoronto.ca
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NR 38
TC 30
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 97
EP 107
DI 10.1016/j.heares.2007.08.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000011
PM 17850999
ER
PT J
AU Hsieh, IH
Saberi, K
AF Hsieh, I-Hui
Saberi, Kourosh
TI Temporal integration in absolute identification of musical pitch
SO HEARING RESEARCH
LA English
DT Article
DE pitch; music; memory; temporal integration; psychophysics
ID HEARING-IMPAIRED LISTENERS; ITERATED RIPPLED NOISE; FREQUENCY
DISCRIMINATION; SHORT-DURATION; VIRTUAL PITCH; MODEL; TONES; PERCEPTION;
SIGNALS; SINGLE
AB The effect of stimulus duration on absolute identification of musical pitch was measured in a single-interval 12-alternative forced-choice task. Stimuli consisted of pure tones selected randomly on each trial from a set of 60 logarithmically spaced musical note frequencies from 65.4 to 1975.5 Hz (C2-B6). Stimulus durations were 5, 10, 25, 50, 100, and 1000 ins. Six absolute-pitch musicians identified the pitch of pure tones without feedback, reference sounds, or practice trials. Results showed that a 5 ins stimulus is sufficient for producing statistically significant above chance performance. Performance monotonically increased up to the longest duration tested (1000 ms). Higher octave stimuli produced better performance, though the rate of improvement declined with increasing octave number. Normalization by the number of waveform cycles showed that 4 cycles are sufficient for absolute-pitch identification. Restricting stimuli to a fixed-cycle waveform instead of a fixed-duration still produced monotonic improvements in performance as a function of stimulus octave, demonstrating that better performance at higher frequencies does not exclusively result from a larger number of waveform cycles. Several trends in the data were well predicted by an autocorrelation model of pitch extraction, though the model outperformed observed performance at short durations suggesting an inability to make optimal use of available periodicity information in very brief tones. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Cognit Sci, Ctr Cognit Neurosci, Irvine, CA 92697 USA.
RP Saberi, K (reprint author), Univ Calif Irvine, Dept Cognit Sci, Ctr Cognit Neurosci, Irvine, CA 92697 USA.
EM saberi@uci.edu
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NR 48
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 108
EP 116
DI 10.1016/j.heares.2007.08.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000012
PM 17919863
ER
PT J
AU De Boer, J
Thornton, ARD
AF De Boer, Jessica
Thornton, A. Roger D.
TI Effect of subject task on contralateral suppression of click evoked
otoacoustic emissions
SO HEARING RESEARCH
LA English
DT Article
DE medial olivocochlear bundle; otoacoustic emission; contralateral
suppression; subject task
ID PERIPHERAL AUDITORY LATERALIZATION; MEDIAL OLIVOCOCHLEAR SYSTEM;
INFERIOR COLLICULUS; SELECTIVE ATTENTION; EFFERENT ACTIVITY;
NON-MUSICIANS; HUMANS; NOISE; ASYMMETRY; COCHLEA
AB Contralateral suppression of click evoked otoacoustic emissions (CEOAEs) is widely used as a non-invasive measure of the activity of the (uncrossed) medial olivocochlear bundle (MOCB). There is evidence that the uMOCB receives descending input from the cortex, potentially mediating top-down control during higher order processing. This study investigated whether the contralateral suppression measure is affected by top-down influences during different tasks performed by the participants during recording. Suppression of CEOAEs evoked at 50 and 60 dB SPL was measured under four different task conditions: (1) no task; (2) passive visual (watching a silent subtitled DVD); (3) active visual (responding to visually presented sums); (4) active auditory (detecting tone pips embedded in the evoking click train). The most significant effect of task was found on the recording noise, with both the passive visual and the active auditory task producing significantly lower noise levels than the no task condition. In the passive visual task, this was associated with a reduced inter-subject variability, which enhanced the effect size relative to the no task condition. A main effect of subject task was also found on the change in CEOAE I/O slope due to contralateral noise. This effect reflected a significantly smaller suppression during the active auditory task compared to the no task condition, leading to a reduced effect size. No significant difference in suppression strength between the no task condition and the two non-auditory tasks was observed, suggesting that the main effect of task reflects a specific effect of auditory attention. The data suggest that MOCB activity is inhibited due to top-down influences when selective attention is focussed on the ipsilateral ear. (C) 2007 Elsevier B.V. All rights reserved.
C1 Royal S Hants Hosp, MRC Inst Hearing Res, Southampton SO14 0YG, Hants, England.
RP De Boer, J (reprint author), Royal S Hants Hosp, MRC Inst Hearing Res, Brintons Terrace,Mailpoint OAU, Southampton SO14 0YG, Hants, England.
EM jdb@soton.ac.uk
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NR 32
TC 31
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 117
EP 123
DI 10.1016/j.heares.2007.08.002
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000013
PM 17910996
ER
PT J
AU Hutson, KA
Durham, D
Tucci, DL
AF Hutson, K. A.
Durham, D.
Tucci, D. L.
TI Consequences of unilateral hearing loss: Time dependent regulation of
protein synthesis in auditory brainstem nuclei
SO HEARING RESEARCH
LA English
DT Article
ID VENTRAL COCHLEAR NUCLEUS; SUPERIOR OLIVARY COMPLEX; EAR OSSICLE REMOVAL;
GUINEA-PIG; AFFERENT INFLUENCES; INFERIOR COLLICULUS; MONGOLIAN GERBIL;
ACOUSTIC CHIASM; CELL-SIZE; DIRECTIONAL RESPONSES
AB Conductive hearing impairment results in marked changes in neuronal activity in the central auditory system, particularly in young animals [Tucci, D-L.. Cant, N.B., Durham. D., 1999. Conductive hearing loss results in a decrease in central auditory system activity in the young gerbil. Laryngoscope 109, 1359-1371]. To better understand the effects of conductive hearing loss (CHL) on cellular metabolism, incorporation of H-3-leucine was used as a measure of protein synthesis in immature postnatal day 21 gerbils subjected to either unilateral CHL by malleus removal or profound sensorineural hearing loss by cochlear ablation. H-3-leucine uptake was measured after survival times of 6 or 48 h. Protein synthesis values were standardized to measurements from the abducens nucleus and compared with measurements from sham animals at similar age/survival times. Protein synthesis in the media] superior olive (MSO) was found to be significantly down-regulated (bilaterally) after CHL in animals surviving 48 h. However, 6 h after CHL manipulation, protein synthesis is up-regulated in MSO (bilaterally) and in the ipsilateral medial nucleus of the trapezoid body. (C) 2007 Elsevier B.V. All rights reserved.
C1 Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Durham, NC 27710 USA.
Univ Kansas, Med Ctr, Dept Otolaryngol, Kansas City, KS 66160 USA.
RP Tucci, DL (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Box 3805, Durham, NC 27710 USA.
EM tucci001@mc.duke.edu
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NR 80
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2007
VL 233
IS 1-2
BP 124
EP 134
DI 10.1016/j.heares.2007.08.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 228QG
UT WOS:000250744000014
PM 17919862
ER
PT J
AU Hordichok, AJ
Steyger, PS
AF Hordichok, Andrew J.
Steyger, Peter S.
TI Closure of supporting cell scar formations requires dynamic actin
mechanisms
SO HEARING RESEARCH
LA English
DT Article
DE hair cell; extrusion; cell death; actin; myosin; microtubules;
supporting cells; inner ear; saccule; vestibular system; in vitro
ID VESTIBULAR SENSORY EPITHELIA; CHICK BASILAR PAPILLA; OUTER HAIR-CELLS;
INNER-EAR; ACOUSTIC TRAUMA; AMINOGLYCOSIDE TOXICITY; CARCINOSARCOMA
CELLS; COCHLEAR EPITHELIUM; OTOLITH ORGANS; IN-VITRO
AB In many vertebrate inner ear sensory epithelia, dying sensory hair cells are extruded, and the apices of surrounding supporting cells converge to re-seal the epithelial barrier between the electrochemically-distinct endolymph and perilymph. These cellular mechanisms remain poorly understood. Dynamic microtubular mechanisms have been proposed for hair cell extrusion; while contractile actomyosin-based mechanisms are required for cellular extrusion and closure in epithelial monolayers. The hypothesis that cytoskeletal mechanisms are required for hair cell extrusion and supporting cell scar formation was tested using bullfrog saccules incubated with gentamicin (6 h), and allowed to recover (18 h). Explants were then fixed, labeled for actin and cytokeratins, and viewed with confocal microscopy. To block dynamic cytoskeletal processes, disruption agents for microtubules (colchicine, paclitaxel) myosin (Y-27632, ML-9) or actin (cytochalasin D, latrunctilin A) were added during treatment and recovery. Microtubule disruption agents had no effect on hair cell extrusion or supporting cell scar formation. Myosin disruption agents appeared to slow down scar formation but not hair cell extrusion. Actin disruption agents blocked scar formation, and largely prevented hair cell extrusion. These data Suggest that actin-based cytoskeletal processes are required for hair cell extrusion and supporting cell scar formation in bullfrog saccules. (C) 2007 Elsevier B.V. All rights reserved.
C1 Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
RP Steyger, PS (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM steygerp@ohsu.edu
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NR 66
TC 16
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 1
EP 19
DI 10.1016/j.heares.2007.06.011
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900001
PM 17716843
ER
PT J
AU Li, H
Lim, KM
AF Li, Hailong
Lim, Kian-Meng
TI Contribution of outer hair cell bending to stereocilium deflection in
the cochlea
SO HEARING RESEARCH
LA English
DT Article
DE outer hair cell; vibration modes; bending; stereocilium deflection
ID MECHANICAL RESPONSES; CORTI KINEMATICS; FORCE GENERATION; GUINEA-PIG;
ORGAN; AMPLIFIER; MOTILITY; MODEL; TRANSDUCTION; MEMBRANE
AB The outer hair cell (OHC) in the cochlea is believed to actively enhance the cochlear sensitivity and frequency selectivity. Besides the well-known axial length change of the OHC, the bending mode of the OHC may also contribute to the stereocilium deflection. To investigate the contribution of the OHC bending to the stereocilium deflection, and the active process in the cochlea, we develop a simple kinematic model of the organ of Corti, consisting of the reticular lamina, the stereocilia and tectorial membrane. The electrically evoked axial length change and bending of the OHC are simulated, and their contributions to the stereocilium deflection are obtained. At the apical turn of the cochlea, the bending mode of the OHC results in stereocilium deflection comparable to that due to the axisymmetric length change of the OHC. At the basal turn, the contribution of the bending mode to the stereocilium deflection becomes insignificant compared to that of the axisymmetric mode. (C) 2007 Elsevier B.V. All rights reserved.
C1 Natl Univ Singapore, Dept Mech Engn, Singapore 117576, Singapore.
Singapore MIT Alliance, Singapore 117576, Singapore.
RP Li, H (reprint author), Natl Univ Singapore, Dept Mech Engn, 9 Engn Dr 1, Singapore 117576, Singapore.
EM g0306044@nus.edu.sg; limkm@nus.edu.sg
RI Lim, Kian-Meng/B-2556-2010
OI Lim, Kian-Meng/0000-0003-4311-9223
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NR 36
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 20
EP 28
DI 10.1016/j.heares.2007.05.012
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900002
PM 17629426
ER
PT J
AU Parker, MA
Corliss, DA
Gray, B
Anderson, JK
Bobbin, RP
Snyder, EY
Cotanche, DA
AF Parker, Mark A.
Corliss, Deborah A.
Gray, Brianna
Anderson, Julia K.
Bobbin, Richard P.
Snyder, Evan Y.
Cotanche, Douglas A.
TI Neural stem cells injected into the sound-damaged cochlea migrate
throughout the cochlea and express markers of hair cells, supporting
cells, and spiral ganglion cells
SO HEARING RESEARCH
LA English
DT Article
DE stem cell; hearing loss; spiral ganglion; hair cell
ID INNER-EAR; ACOUSTIC TRAUMA; MOUSE COCHLEA; GENE-THERAPY; GUINEA-PIGS;
NEURONS; REPLACEMENT; TRANSPLANTATION; REGENERATION; REPAIR
AB Most cases of hearing loss are caused by the death or dysfunction of one of the many cochlear cell types. We examined whether cells from a neural stem cell line could replace cochlear cell types lost after exposure to intense noise. For this purpose, we transplanted a clonal stem cell line into the scala tympani of sound damaged mice and guinea pigs. Utilizing morphological, protein expression and genetic criteria, stem cells were found with characteristics of both neural tissues (satellite, spiral ganglion, and Schwann cells) and cells of the organ of Corti (hair cells, supporting cells). Additionally, noise-exposed, stem cell-injected animals exhibited a small but significant increase in the number of satellite cells and Type I spiral ganglion neurons compared to non-injected noise-exposed animals. These results indicate that cells of this neural stem cell line migrate from the scala tympani to Rosenthal's canal and the organ of Corti. Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea. (C) 2007 Elsevier B.V. All rights reserved.
C1 Emerson Coll, Dept Commun Sci & Disorders, Boston, MA 02116 USA.
Childrens Hosp, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
LSU Hlth Sci Ctr, Dept Otolaryngol, Kresge Hearing Res Labs, New Orleans, LA USA.
Burnham Inst, La Jolla, CA 92037 USA.
Hlth Sci & Technol Program, Boston, MA USA.
RP Parker, MA (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM Mark_Parker@meei.harvard.edu
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NR 44
TC 38
Z9 49
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 29
EP 43
DI 10.1016/j.heares.2007.06.007
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900003
PM 17659854
ER
PT J
AU Minoda, R
Izumikawa, M
Kawamoto, K
Zhang, H
Raphael, Y
AF Minoda, Ryosei
Izumikawa, Masahiko
Kawamoto, Kohei
Zhang, Hui
Raphael, Yehoash
TI Manipulating cell cycle regulation in the mature cochlea
SO HEARING RESEARCH
LA English
DT Article
DE adenovirus; gene transfer; p27Kip1; Atoh1; Skp2; guinea pig; hair cell;
supporting cell; BrdU
ID MAMMALIAN INNER-EAR; HAIR-CELLS; ACOUSTIC TRAUMA; CHICK COCHLEA;
GENE-TRANSFER; HEARING-LOSS; IN-VIVO; PROLIFERATION; REGENERATION;
P27(KIP1)
AB Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cells that remain in the deaf ear and induce transdifferentiation of some of these cells into the hair cell phenotype. Several genes, including p27(kipl), have been shown to regulate proliferation and differentiation in the developing auditory epithelium. The role of p27(Kipl) in the mature ear is not well characterized. We now show that p2(Kipl) is present in the nuclei of nonsensory cells of the mature auditory epithelium. We determined that forced expression of Skp2 using a recombinant adenovirus vector, resulted in presence of BrdU-positive cells in the auditory epithelium. When SKP2 over-expression was combined with forced expression of Atohl, ectopic hair cells were found in the auditory epithelium in greater numbers than were seen with Atohl alone. Skp2 over-expression alone did not result in ectopic hair cells. These findings suggest that the p271(Kipl) protein remains in the mature auditory epithelium and therefore P27(Kipl) can serve as a target for gene manipulation. The data also suggest that induced proliferation, by itself, does not generate new hair cells in the cochlea. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Kumamoto Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kumamoto 8608556, Japan.
Kansai Med Univ, Dept Otolaryngol Head & Neck Surg, Osaka 5708506, Japan.
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, MSRB 3,Rm 9303 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
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NR 36
TC 22
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 44
EP 51
DI 10.1016/j.heares.2007.06.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900004
PM 17658230
ER
PT J
AU Buchholz, JM
AF Buchholz, Joerg M.
TI Characterizing the monaural and bincaural processes underlying
reflection masking
SO HEARING RESEARCH
LA English
DT Article
DE auditory masking; binaural hearing; models of auditory function;
precedence effect
ID SIGNAL-DEPENDENT COMPRESSION; REPRODUCED SOUND; TIMBRAL ASPECTS; SMALL
ROOMS; MODEL; COLORATION; PERCEPTION; FIELDS
AB Reflection masked thresholds (RMTs) for the simple scenario of a test reflection masked by the direct sound (200 ms long broadband noise) were measured as a function of reflection delay for diotic and dichotic stimulus presentations. In order to discriminate between contributions to reflection masking from simultaneous versus forward masking, the simultaneous RMT was measured in addition to the traditional RMT. Simultaneous RM was realized by truncating the offset of the test reflection such that the test reflection and the direct sound had a common offset. By comparing the experimental results for the two RMTs, it is shown that forward masking effects only have a significant effect on reflection masking for delays above 7-10 ms. Moreover, binaural mechanisms were revealed which deteriorate auditory detection of test reflections for delays below 7-10 ms and enhance detection for larger delays. The monaural and binaural processes that may underlie reflection masking are discussed in terms of auditory-modelling concepts. (C) 2007 Elsevier B.V. All rights reserved.
C1 Ctr Appl Hearing Res Acoust Technol, DK-2800 Lyngby, Denmark.
RP Buchholz, JM (reprint author), Ctr Appl Hearing Res Acoust Technol, Bldg 352, DK-2800 Lyngby, Denmark.
EM jb@oersted.dtu.dk
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NR 38
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 52
EP 66
DI 10.1016/j.heares.2007.06.008
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900005
PM 17664048
ER
PT J
AU Peterson, DC
Schofield, BR
AF Peterson, Diana Coomes
Schofield, Brett R.
TI Projections from auditory cortex contact ascending pathways that
originate in the superior olive and inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
DE medial geniculate; corticofugal; feedback loops; efferent system;
descending pathways
ID BIG BROWN BAT; GUINEA-PIG; CORTICOFUGAL MODULATION; EPTESICUS-FUSCUS;
PARAOLIVARY NUCLEUS; COCHLEAR NUCLEUS; MOUSTACHED BAT; RAT; NEURONS;
COMPLEX
AB The superior olivary complex (SOC) and inferior colliculus (IC) are targets of cortical projections as well as sources of major ascending auditory pathways. This study examines whether the cortical projections contact cells in the SOC or IC that project to higher levels. First, we placed an anterograde tracer into the auditory cortex to label cortico-olivary axons and a retrograde tracer into the IC to label olivocollicular cells in guinea pigs. Cortical axons contacted many labeled cells in the ipsilateral SOC and fewer labeled cells in the contralateral SOC. Contacted cells projected to the ipsilateral or contralateral IC. In a second experiment, we labeled corticocollicular axons with an anterograde tracer and injected retrograde tracers into the medial geniculate (MG) to label colliculogeniculate cells. In the IC ipsilateral to the cortical injection, many cortical axons contacted colliculogeniculate cells in the dorsal cortex and external cortex of the IC. The contacted cells projected to the ipsilateral MG or, less often, to the contralateral MG. The results indicate that cortical projections are likely to contact cells in the SOC and IC that project to higher centers. This suggests that auditory cortex can modulate the ascending auditory pathways at multiple levels of the brainstem. (C) 2007 Elsevier B.V. All rights reserved.
C1 Northeastern Ohio Univ Coll Med & Pharm, Dept Neurobiol, Rootstown, OH 44272 USA.
RP Peterson, DC (reprint author), Northeastern Ohio Univ Coll Med & Pharm, Dept Neurobiol, 4209 State Route 44,POB 95, Rootstown, OH 44272 USA.
EM dcoomes@neoucom.edu; bschofie@ncoucom.edu
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NR 52
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 67
EP 77
DI 10.1016/j.heares.2007.06.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900006
ER
PT J
AU Salt, AN
Sirjani, DB
Hartsock, JJ
Gill, RM
Plontke, SK
AF Salt, Alec N.
Sirjani, Davud B.
Hartsock, Jared J.
Gill, Ruth M.
Plontke, Stefan K.
TI Marker retention in the cochlea following injections through the round
window membrane
SO HEARING RESEARCH
LA English
DT Article
DE drug delivery; round window membrane; perilymph; pharmacokinetics; inner
ear
ID GUINEA-PIG; SCALA TYMPANI; INNER-EAR; INTRACOCHLEAR INFUSION;
CONCENTRATION GRADIENT; DRUG-DELIVERY; GENE-TRANSFER; NEUROTROPHINS;
COCHLEOSTOMY; GENTAMICIN
AB Local delivery of drugs to the inner ear is increasingly being used in both clinical and experimental studies. Although direct injection of drugs into perilymph appears to be the most promising way of administering drugs quantitatively, no studies have yet demonstrated the pharmacokinetics in perilymph following direct injections. In this study, we have investigated the retention of substance in perilymph following a single injection into the basal turn of scala tympani (ST). The substance injected was a marker, trimethylphenylammonium (TMPA) that can be detected in low concentrations with ion-selective microelectrodes. Perilymph pharmacokinetics of TMPA was assessed using sequential apical sampling to obtain perilymph for analysis. The amount of TMPA retained in perilymph was compared for different injection and sampling protocols. TMPA concentrations measured in fluid samples were close to those predicted by simulations when the injection pipette was sealed into the bony wall of ST but were systematically lower when the injection pipette was inserted through the round window membrane (RWM). In the latter condition, it was estimated that over 60% of the injected TMPA was lost due to leakage of perilymph around the injection pipette at a rate estimated to be 0.09 mu L/min. The effects of leakage during and after injections through the RWM were dramatically reduced when the round window niche was filled with 1% sodium hyaluronate gel before penetrating the RWM with the injection pipette. The findings demonstrate that in order to perform quantitative drug injections into perilymph, even small rates of fluid leakage at the injection site must be controlled. (C) 2007 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
Univ Tubingen, Dept Otolaryngol Head & Neck Surg, D-72076 Tubingen, Germany.
Univ Tubingen, Tubingen Hearing Res Ctr, D-72076 Tubingen, Germany.
RP Salt, AN (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA.
EM salta@msnotes.wustl.edu
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NR 23
TC 11
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 78
EP 86
DI 10.1016/j.heares.2007.06.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900007
PM 17662546
ER
PT J
AU Nourski, KV
Abbas, PJ
Miller, CA
Robinson, BK
Jeng, FC
AF Nourski, Kirill V.
Abbas, Paul J.
Miller, Charles A.
Robinson, Barbara K.
Jeng, Fuh-Cherng
TI Acoustic-electric interactions in the guinea pig auditory nerve:
Simultaneous and forward masking of the electrically evoked compound
action potential
SO HEARING RESEARCH
LA English
DT Article
DE adaptation; cochlear implant; deafening; electric-acoustic stimulation;
guinea pig; recovery
ID SHORT-TERM ADAPTATION; PULSE TRAINS; COCHLEAR IMPLANTATION; FIBER
RESPONSES; HEARING-LOSS; HAIR-CELLS; STIMULATION; FUROSEMIDE;
OTOTOXICITY; RECORDINGS
AB The Study investigated the time course of the effects of acoustic and electric stimulation on the electrically evoked compound action potential (ECAP). Adult guinea pigs were used in acute experimental sessions. Bursts of acoustic noise and high-rate (5000 pulses/s) electric pulse trains were used as maskers. Biphasic electric pulses were used as probes. ECAPs were recorded from the auditory nerve trunk. Simultaneous masking of the ECAP with acoustic noise featured an onset effect and a decrease in the amount of masking to a steady state. It was characterized by a two-component exponential function. The amount of masking increased with masker level and decreased with probe level. Post-stimulatory ECAP recovery often featured a non-monotonic time course, described by a three-component exponent. Electric maskers produced similar post-stimulatory effects in hearing and acutely deafened subjects. Acoustic stimulation affects the ECAP in a level- and time-dependent manner. Simultaneous masking follows a time course comparable to that of adaptation to an acoustic stimulus. Refractoriness, spontaneous activity, and adaptation are suggested to play a role in ECAP recovery. Post-stimulatory changes in synchrony, possibly due to recovery of spontaneous activity and an additional hair-cell independent mechanism, are hypothesized to contribute to the observed non-monotonicity of recovery. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
RP Nourski, KV (reprint author), Univ Iowa, Dept Neurosurg, 3024 Boyd Tower, Iowa City, IA 52242 USA.
EM kirill-nourski@uiowa.edu
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NR 60
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2007
VL 232
IS 1-2
BP 87
EP 103
DI 10.1016/j.heares.2007.07.001
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 223JA
UT WOS:000250364900008
PM 17723284
ER
PT J
AU Versnel, H
Agterberg, MJH
de Groot, JCMJ
Smoorenburg, GF
Klis, SFL
AF Versnel, Huib
Agterberg, Martijn J. H.
de Groot, John C. M. J.
Smoorenburg, Guido F.
Klis, Sjaak F. L.
TI Time course of cochlear electrophysiology and morphology after combined
administration of kanamycin and furosemide
SO HEARING RESEARCH
LA English
DT Article
DE deafness; ototoxicity; recovery; cochlear hair cells; spiral ganglion
cells; electrocochleography
ID ALBINO GUINEA-PIG; SPIRAL GANGLION NEURONS; HAIR CELL LOSS;
ETHACRYNIC-ACID; NEUROTROPHIC FACTOR; HEARING-LOSS;
ELECTRICAL-STIMULATION; CISPLATIN OTOTOXICITY; SURVIVAL; DEGENERATION
AB In animal models of deafness, administration of an aminoglycoside in combination with a loop diuretic is often applied to produce a rapid loss of cochlear hair cells. However, the extent to which surviving hair cells remain functional after such a deafening procedure varies. In a longitudinal electrocochleographical study, we investigated the variability of cochlear function between and within guinea pigs after combined administration of kanamycin and furosemide. Concurrently, histological data were obtained at 1, 2, 4 and 8 weeks after deafening treatment. The main measures in our study were compound action potential (CAP) thresholds, percentage of surviving hair cells and packing density of spiral ganglion cells (SGCs). One day after deafening treatment, we found threshold shifts widely varying among animals from 0 to 100 dB. The variability decreased after 2 days, and in 18 out of 20 animals threshold shifts greater than 55 dB were found 4-7 days after deafening. Remarkably, in the majority of animals, thresholds decreased by up to 25 dB after 7 days indicating functional recovery. As expected, final thresholds were negatively correlated to the percentage of surviving hair cells. Notably, the percentage of surviving hair cells might be predicted on the basis of thresholds observed one day after deafening. SGC packing density, which rapidly decreased with the period after deafening treatment and correlated to the percentage of surviving inner hair cells, was not a determining factor for the CAP thresholds. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Otorhinolaryngol, NL-3508 GA Utrecht, Netherlands.
RP Versnel, H (reprint author), Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Otorhinolaryngol, POB 85500, NL-3508 GA Utrecht, Netherlands.
EM h.versnel@umcutrecht.nl; M.J.H.Agterberg@umcutrecht.nl;
J.C.M.J.deGroot@umcutrecht.nl; guido.smoorenburg@wanadoo.fr
RI Agterberg, Martijn/K-2956-2012
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NR 30
TC 36
Z9 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 1
EP 12
DI 10.1016/j.heares.2007.03.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300001
PM 17475424
ER
PT J
AU Sellick, PM
AF Sellick, Peter M.
TI Long term effects of BAPTA in scala media on cochlear function
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; tip links; BAPTA; outer hair cells; permanent threshold shifts
ID PRODUCT OTOACOUSTIC EMISSIONS; SENSORY HAIR BUNDLES; CELL TRANSDUCTION
CHANNELS; TEMPORARY THRESHOLD SHIFT; GUINEA-PIG; TIP LINKS; CALCIUM
CHELATION; MECHANICAL TRANSDUCTION; LOUD SOUND; LOW-LEVEL
AB BAPTA was iontophoresed or allowed to diffuse into the scala media of the first turn of the guinea pig cochlea via pipettes inserted through the round window and basilar membrane. Cochlear action potential (CAP) thresholds for basal turn frequencies were elevated, scala media cochlear microphonic in response to a 207 Hz tone were drastically reduced and the distortion products 2f1-f2 and f2-f2 in response to primaries set at 18 and 21.6 kHz were eliminated or severely reduced. The animals were recovered and the above measurements repeated between 24 and 240 It after the application of BAPTA. In all animals thresholds for basal turn frequencies remained elevated, and the distortion components were severely reduced. The endolymphatic potential (EP), measured through the basilar membrane on recovery, was not significantly different from the values measured before BAPTA was applied. If the effect of BAPTA, in lowering endolymphatic Ca2+ concentration, is restricted to the destruction of tip links, as has been shown in many other preparations, then these results suggest that this effect has permanent consequences, either because the tip links failed to regenerate or because their destruction precipitated the degeneration of OHCs. These results may have a bearing on the mechanisms behind permanent threshold shift. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Western Australia, Sch Biomed Biomol & Chem Sci, Discipline Physiol, Auditory Lab, Nedlands, WA 6009, Australia.
RP Sellick, PM (reprint author), Univ Western Australia, Sch Biomed Biomol & Chem Sci, Discipline Physiol, Auditory Lab, Nedlands, WA 6009, Australia.
EM psellick@cyllene.uwa.edu.au
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NR 30
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 13
EP 22
DI 10.1016/j.heares.2007.04.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300002
PM 17509783
ER
PT J
AU Zheng, QY
Tong, YCI
Alagramam, KN
Yu, HP
AF Zheng, Qing Yin
Tong, Yi-Cai Isaac
Alagramam, Kumar N.
Yu, Heping
TI Tympanometry assessment of 61 inbred strains of mice
SO HEARING RESEARCH
LA English
DT Article
DE tympanometry; mouse models; middle ear; otitis media
ID ACUTE OTITIS-MEDIA; BRAIN-STEM RESPONSES; MIDDLE-EAR; LP/J MICE;
TYMPANIC MEMBRANE; HEARING-LOSS; MOUSE MODEL; ABORIGINAL CHILDREN; GENE;
EFFUSION
AB Otitis media (OM) accounts for more than 20 million clinic visits in the United States every year. Resistance to antibiotics has hampered current management of the disease. Identification of genetic factors underlying susceptibility to OM is greatly needed in order to develop alternative treatment strategies. Genetically defined inbred mouse strains offer a powerful tool for dissecting genetic and environmental factors that may lead to OM in mice. Here, we report a study of middle ear function of 61 genetically diverse inbred strains of mice using tympanometry. Of the 61 inbred strains tested, the 129PI/ReJ, 129P3/J, 129SI/SvImJ, 129XI/SvJ, A/HeJ, BALB/0, BUB/BnJ, C57L/3, EL/SuzSeyFrkJ, FVB/NJ, I/LnJ, LP/J, NZB/BINJ, PL/J and YBR/Ei strains exhibited tympanograms that were statistically different from other healthy strains according to parameters including middle ear pressure, volume and compliance. These differences are most likely the result of genetic factors that, when understood, will facilitate prevention and treatment of otitis media in humans. In addition, a negative correlation between age and compliance of the tympanic membrane was discovered. This is the first report to successfully use tympanometry to measure mouse middle ear function, which has been a challenge for the hearing research field because of the mouse's tiny ear size. (c) 2007 Elsevier B.V. All rights reserved.
C1 Case Western Reserve Univ, Dept Otolaryngol Head & Neck Surg, Cleveland, OH 44106 USA.
Jackson Lab, Bar Harbor, ME 04609 USA.
RP Zheng, QY (reprint author), Case Western Reserve Univ, Dept Otolaryngol Head & Neck Surg, 11100 Euclid Ave,LKS 5045, Cleveland, OH 44106 USA.
EM qyz@case.edu
RI Zheng, Qing/C-1731-2012
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NR 57
TC 8
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 23
EP 31
DI 10.1016/j.heares.2007.05.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300003
PM 17611057
ER
PT J
AU Gaudrain, E
Grimault, N
Healy, EW
Bera, JC
AF Gaudrain, Etienne
Grimault, Nicolas
Healy, Eric W.
Bera, Jean-Christophe
TI Effect of spectral smearing on the perceptual segregation of vowel
sequences
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 12th International Symposium on Audiological Medicine
CY MAR, 2005
CL Lyon, FRANCE
DE streaming; vowel sequences; hearing impairment; spectral smearing
ID AUDITORY STREAM SEGREGATION; HEARING-IMPAIRED LISTENERS; COMPLEX-TONE
SEQUENCES; FUNDAMENTAL-FREQUENCY; NORMALLY HEARING; TEMPORAL ORDER;
SPEECH; ORGANIZATION; DISCRIMINATION; SELECTIVITY
AB Although segregation of both simultaneous and sequential speech items may be involved in the reception of speech in noisy environments, research on the latter is relatively sparse. Further, previous studies examining the ability of hearing-impaired listeners to form distinct auditory streams have produced mixed results. Finally, there is little work investigating streaming in cochlear implant recipients, who also have poor frequency resolution. The present study focused on the mechanisms involved in the segregation of vowel sequences and potential limitations to segregation associated with poor frequency resolution. An objective temporal-order paradigm was employed in which listeners reported the order of constituent vowels within a sequence. In Experiment 1, it was found that fundamental frequency based mechanisms contribute to segregation. In Experiment 2, reduced frequency tuning often associated with hearing impairment was simulated in normal-hearing listeners. In that experiment, it was found that spectral smearing of the vowels increased accurate identification of their order, presumably by reducing the tendency to form separate auditory streams. These experiments suggest that a reduction in spectral resolution may result in a reduced ability to form separate auditory streams, which may contribute to the difficulties of hearing-impaired listeners, and probably cochlear implant recipients as well, in multi-talker cocktail-party situations. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Lyon 1, CNRS, UMR 5020, Lyon, France.
Univ S Carolina, Dept Commun Sci & Disorders, Speech Psychoacoust Lab, Columbia, SC 29208 USA.
INSERM, U556, F-69008 Lyon, France.
RP Grimault, N (reprint author), Univ Lyon 1, CNRS, UMR 5020, Lyon, France.
EM ngrimault@olfac.univ-lyon1.fr
RI Gaudrain, Etienne/C-6713-2013
OI Gaudrain, Etienne/0000-0003-0490-0295
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NR 46
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 32
EP 41
DI 10.1016/j.heares.2007.05.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300004
PM 17597319
ER
PT J
AU Carroll, J
Zeng, FG
AF Carroll, Jeff
Zeng, Fan-Gang
TI Fundamental frequency discrimination and speech perception in noise in
cochlear implant simulations
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 28th Midwinter Meeting of the Association-of-Research-in-Otolaryngology
CY FEB 19-24, 2005
CL New Orleans, LA
SP Assoc Res Otolaryngol
DE speech in noise; segregation; vocoder; spectral resolution
ID ACOUSTIC HEARING; INSTANTANEOUS-FREQUENCY; VOWEL IDENTIFICATION;
TEMPORAL CUES; RECOGNITION; PITCH; STIMULATION; AMPLITUDE; NUMBER;
PROCESSORS
AB Increasing the number of channels at low frequencies improves discrimination of fundamental frequency (170) in cochlear implants (Geurts, L., Wouters, J., 2004. Better place-coding of the fundamental frequency in cochlear implants. J. Acoust. Soc. Am. 115 (2), 844-852). We conducted three experiments to test whether improved F0 discrimination can be translated into increased speech intelligibility in noise in a cochlear implant simulation. The first experiment measured F0 discrimination and speech intelligibility in quiet as a function of channel density over different frequency regions. The results from this experiment showed a tradeoff in performance between F0 discrimination and speech intelligibility with a limited number of channels. The second experiment tested whether improved F0 discrimination and optimizing this tradeoff could improve speech performance with a competing talker. However, improved F0 discrimination did not improve speech intelligibility in noise. The third experiment identified the critical number of channels needed at low frequencies to improve speech intelligibility in noise. The result showed that, while 16 channels below 500 Hz were needed to observe any improvement in speech intelligibility in noise, even 32 channels did not achieve normal performance. Theoretically, these results suggest that without accurate spectral coding, F0 discrimination and speech perception in noise are two independent processes. Practically, the present results illustrate the need to increase the number of independent channels in cochlear implants. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Biomed Engn, Hearing & Speech Res Lab, Irvine, CA 92697 USA.
Univ Calif Irvine, Dept Anat & Neurobiol, Hearing & Speech Res Lab, Irvine, CA 92697 USA.
Univ Calif Irvine, Dept Cognit Sci, Hearing & Speech Res Lab, Irvine, CA 92697 USA.
Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Hearing & Speech Res Lab, Irvine, CA 92697 USA.
RP Carroll, J (reprint author), Univ Calif Irvine, Dept Biomed Engn, Hearing & Speech Res Lab, Irvine, CA 92697 USA.
EM carrollj@uci.edu; fzeng@uci.edu
RI Zeng, Fan-Gang/G-4875-2012
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NR 45
TC 20
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 42
EP 53
DI 10.1016/j.heares.2007.05.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300005
PM 17604581
ER
PT J
AU Jedrzejczak, WW
Hatzopoulos, S
Martini, A
Blinowska, KJ
AF Jedrzejczak, W. Wiktor
Hatzopoulos, Stavros
Martini, Alessandro
Blinowska, Katarzyna J.
TI Otoacoustic emissions latency difference between full-term and preterm
neonates
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; preterm newborn; time-frequency distribution;
adaptive approximations
ID TIME-FREQUENCY ANALYSIS; DISTORTION-PRODUCT; LONGITUDINAL MEASUREMENTS;
MIDDLE-EAR; INFANTS; IDENTIFICATION; NOISE
AB Transiently evoked otoacoustic emissions (TEOAEs) were recorded from full-term and preterm neonates. The responses were decomposed, by means of an adaptive approximation method, into waveforms of defined frequencies, amplitudes, latencies and time spans. Statistically significant differences in the latency values were found between the tested groups. Differences were also found in the time spans of the TEOAEs components. For the preterm neonates the contribution of long-duration components (i.e. long-time span) was higher. Those components were characterized by narrow frequency band and contrary to the short-time span components their latencies did not depend on frequency. The removal of the long-duration components, from the pool of analyzed data, decreased the latency differences between the tested groups. The results indicate that the origin of the longer latency values for preterm. neonates (with a post conceptional age up to 33 weeks) in respect to full-term neonates can be attributed to the presence of long-lasting components. The correspondence, which was found between frequencies of long-duration components and the spectral peaks of spontaneous otoacoustic emissions (SOAEs), suggests that those components may be connected with SOAEs. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Warsaw, Inst Expt Phys, Dept Biomed Phys, PL-00681 Warsaw, Poland.
Inst Physiol & Pathol Hearing, PL-01943 Warsaw, Poland.
Univ Ferrara, Dept Audiol, I-44100 Ferrara, Italy.
RP Jedrzejczak, WW (reprint author), Univ Warsaw, Inst Expt Phys, Dept Biomed Phys, Ul Hoza 69, PL-00681 Warsaw, Poland.
EM wieslaw.jedrzejczak@fuw.edu.pl
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NR 32
TC 16
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 54
EP 62
DI 10.1016/j.heares.2007.05.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300006
PM 17606343
ER
PT J
AU Caicci, F
Burighel, P
Manni, L
AF Caicci, F.
Burighel, P.
Manni, L.
TI Hair cells in an ascidian (Tunicata) and their evolution in chordates
SO HEARING RESEARCH
LA English
DT Article
DE ascidians; coronal organ; neural placodes; oral siphon; sensory system;
tentacles
ID NERVOUS-SYSTEM; NEURAL CREST; SENSORY CELLS; LATERAL-LINE; PLACODES;
ORIGIN; ORGAN; ORGANIZATION
AB In ascidians, mechanoreceptors of the oral area are involved in monitoring the incoming water flow. Sensory cells are represented by scattered, ciliated primary cells (sending their own axons to the cerebral ganglion) or secondary sensory cells (axonless cells forming afferent and efferent synapses with neurons, whose somata are located in the ganglion) of the coronal organ. Coronal cells have varying morphologies: in species of the Enterogona order, they are multiciliate, whereas those of Pleurogona possess an apical apparatus composed of one or two cilia accompanied by stereovilli, in some cases also graded in length. The coronal organ has been proposed as a homologue to the vertebrate octavo-lateralis system, because coronal cells resemble vertebrate hair cells for morphology, embryonic origin and arrangement. In the ascidian Molgula socialis (Pleurogona), we now describe the morphology of the coronal organ, which contains a few associated rows of sensory cells that run the whole length of the oral velum and the branched tentacles. Three kinds of sensory cells, accompanied by specialised supporting cells, are present. Comparisons between the coronal organ and other chordate mechanosensory structures suggest that hair cells originated in the common ancestor of chordates. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Padua, Dept Biol, I-35131 Padua, Italy.
RP Manni, L (reprint author), Univ Padua, Dept Biol, Via U Bassi 58-B, I-35131 Padua, Italy.
EM federico.caicci@unipd.it; paolo.burighel@unipd.it; lucia.manni@unipd.it
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NR 33
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 63
EP 72
DI 10.1016/j.heares.2007.05.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300007
PM 17611058
ER
PT J
AU Mazurek, B
Haupt, H
Amarjargal, N
Yarin, YM
Machulik, A
Gross, J
AF Mazurek, Birgit
Haupt, Heidemarle
Amarjargal, Nyamaa
Yarin, Yuri M.
Machulik, Astrid
Gross, Johann
TI Up-regulation of prestin mRNA expression in the organs of corti of
guinea pigs and rats following unilateral impulse noise exposure
SO HEARING RESEARCH
LA English
DT Article
DE guinea pig; impulse noise-induced hearing loss; otoacoustic emission;
outer hair cell; prestin mRNA; rat
ID OUTER HAIR-CELLS; INDUCED HEARING-LOSS; ACUTE ACOUSTIC TRAUMA; MOTOR
PROTEIN; GENE-EXPRESSION; OTOACOUSTIC EMISSIONS; COCHLEA; ACETYLCHOLINE;
TINNITUS; ELECTROMOTILITY
AB Prestin is the motor protein of the outer hair cells (OHCs) and is required for both their electromotility and for cochlear amplification. We investigated the prestin mRNA expression in guinea pigs and rats in relation to the degree of noise-induced hearing loss (NIHL) induced by unilateral impulse noise exposure (167 dB peak SPL) for 2.5-5 min. Distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses were recorded before and one week post exposure. Prestin mRNA was examined by quantitative reverse transcription-polymerase chain reaction. Either the whole organs of Corti or the apical, middle and basal parts were examined separately. The specimens were pooled and grouped according to the degree of NIHL measured in the exposed ears. In rats, the number of hair cells was counted. A clear base-to-apex gradient in the prestin mRNA expression was found to exist in guinea pig and rat controls. In both species, there was an increase in the number of prestin RNA transcripts at a mean NIHL of about 15-25 dB indicating an upregulation in the remaining intact cells. In rats, this degree of NIHL corresponded to an OHC loss of about 40%. Interestingly, the contralateral ears also revealed an up-regulation of prestin mRNA accompanied by significant DPOAE improvements. (c) 2007 Elsevier B.V. All rights reserved.
C1 Charite Univ Med Berlin, Dept Otorhinolaryngol, Mol Biol Res Lab, D-10117 Berlin, Germany.
Univ Hosp Dresden, Dept Otorhinolaryngol, D-01307 Dresden, Germany.
RP Mazurek, B (reprint author), Charite Univ Med Berlin, Dept Otorhinolaryngol, Mol Biol Res Lab, Campus Charite Mitte,Charitepl 1, D-10117 Berlin, Germany.
EM birgit.mazurek@charite.de
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NR 53
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 73
EP 83
DI 10.1016/j.heares.2007.05.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300008
PM 17592749
ER
PT J
AU Hof-Duin, NJ
Wit, HP
AF Hof-Duin, Nanda J.
Wit, Hero P.
TI Evaluation of low-frequency biasing as a diagnostic tool in Meniere
patients
SO HEARING RESEARCH
LA English
DT Article
DE Meniere; endolymphatic hydrops; low frequency biasing; modulation depth;
cochlear amplifier
ID ENDOLYMPHATIC HYDROPS; IN-VIVO; BASILAR-MEMBRANE; MASKING; MODULATION;
COCHLEA; HEARING; DISEASE; TONES
AB Although it is generally accepted that endolymphatic hydrops is the cause of complaints in patients suffering from Meniere's disease, it has not been possible up to now to prove the presence of an endolymphatic hydrops in living humans. This study evaluated the psychophysical method introduced by Mrowinski et al. [Mrowinski D., Gerull G., Nubel K., Scholz G., 1995. Masking and pitch shift of tone bursts and clicks by low-frequency tones. Hear. Res. 85, 95-102; Mrowinski D., Scholz G., Krompass S., Nubel K., 1996. Diagnosis of endolymphatic hydrops by low-frequency masking. Audiol. Neurootol. 1, 125-134] to diagnose endolymphatic hydrops. These authors used low frequency biasing to differentiate between individuals with and individuals without Meniere's disease. In the present study no statistically significant differences in masking parameters could be found between a large number (n = 91) of ears with Meniere's disease and ears (n = 52) with comparable sensorineural hearing losses, but without symptoms of Meniere's disease. Our results support the idea that results deviating from normal in low frequency biasing measurements are not due to endolymphatic hydrops itself, but to other pathological changes of the inner ear. An explanation could be that with increasing hearing loss the gain of the cochlear amplifier decreases, leading to smaller modulation depths. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Groningen, Fac Med, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, NL-9700 RB Groningen, Netherlands.
RP Hof-Duin, NJ (reprint author), Univ Groningen, Fac Med, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM nj.hof@kno.umcg.nl
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NR 21
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 84
EP 89
DI 10.1016/j.heares.2007.06.004
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300009
PM 17658231
ER
PT J
AU Cooke, JE
Zhang, HM
Kelly, JB
AF Cooke, James E.
Zhang, Huiming
Kelly, Jack B.
TI Detection of sinusoidal amplitude modulated sounds: Deficits after
bilateral lesions of auditory cortex in the rat
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; temporal coding; amplitude modulation; central
processing disorders; cortical damage; behavioral thresholds
ID INFERIOR COLLICULUS; GAP-DETECTION; TEMPORAL CORTEX; NEURONAL RESPONSES;
CORTICAL-LESIONS; NEURAL RESPONSES; ALBINO-RAT; CBA MOUSE; CAT;
FREQUENCY
AB The ability of rats to detect the presence of sinusoidal amplitude modulation (AM) of a broadband noise carrier was determined before and after bilateral ablation of auditory cortex. The rats were trained to withdraw from a drinking spout to avoid a shock when they detected a modulation of the sound. Sensitivity was evaluated by testing the rats at progressively smaller depths of modulation. Psychophysical curves were produced to describe the limits of detection at modulation rates of 10, 100 and 1000 Hz. Performance scores were based on the probability of withdrawal from the spout during AM (warning periods) relative to withdrawal during the un-modulated noise (safe periods). A threshold was defined as the depth of modulation that produced a score halfway between perfect avoidance and no avoidance (performance score = 0.5). Bilateral auditory cortical lesions resulted in significant elevations in threshold for detection of AM at rates of 100 and 1000 Hz. No significant shift was found at a modulation rate of 10 Hz. The magnitude of the deficit for AM rates of 100 and 1000 Hz was positively correlated with the size of the cortical lesion. Substantial deficits were found only in animals with lesions that included secondary as well as primary auditory cortical areas. The results show that the rat's auditory cortex is important for processing sinusoidal AM and that its contribution is most apparent at high modulation rates. The data suggest that the auditory cortex is a crucial structure for maintaining normal sensitivity to temporal modulation of an auditory stimulus. (c) 2007 Elsevier B.V. All rights reserved.
C1 Carleton Univ, Dept Psychol, Lab Sensory Neurosci, Ottawa, ON K1S 5B6, Canada.
RP Kelly, JB (reprint author), Carleton Univ, Dept Psychol, Lab Sensory Neurosci, Ottawa, ON K1S 5B6, Canada.
EM jkelly@ccs.carleton.ca
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NR 77
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2007
VL 231
IS 1-2
BP 90
EP 99
DI 10.1016/j.heares.2007.06.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 208NU
UT WOS:000249327300010
PM 17629425
ER
PT J
AU Andrianov, GN
Nozdrachev, AD
Ryzhova, IV
AF Andrianov, G. N.
Nozdrachev, A. D.
Ryzhova, I. V.
TI The role of defensins in the excitability of the peripheral vestibular
system in the frog: Evidence for the presence of communication between
the immune and nervous systems
SO HEARING RESEARCH
LA English
DT Article
DE defensins; neuromodulation afferent synapse; hair cells; semicircular
canal; frog
ID METABOTROPIC GLUTAMATE RECEPTORS; HAIR-CELLS; OPIOID RECEPTORS;
ANTIMICROBIAL PEPTIDES; TRANSMITTER RELEASE; MEDIATED RESPONSE;
RANA-PIPIENS; ORGANS; INTERFERON; RAT
AB Defensins are one of the major groups of endogenous peptides that are considered to be important antibiotic-like effectors of host innate and adaptive antimicrobial immunity. The current study investigated the electrophysiological effects of externally applied human and rabbit defensins (HNP-1 and RNP-1, correspondingly) on afferent neurotransmission in the frog semicircular canals (SCC). Application of HNP-1 and RNP-1 induces a concentration-dependent decrease in resting activity. Threshold concentrations for both substances were of the order of 0.0001 nM. The firing evoked by L-glutamate (L-Glu) and its agonists alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), kainate and N-methyl-D-aspartate (NMDA) and (1S, 3R)-1-aminocyclopentane-trans- 1,3-dicarboxilic acid (ACPD) could be inhibited by HNP-1, suggesting that defensins exert inhibitory control over both ionotropic and metabotropic glutamate receptors. HNP-1 considerably inhibited the L-glutamate/high Mg2+- induced increase in frequency, thus, demonstrating its postsynaptic site of action. Acetylcholine (ACh) responses under HNP-1 did not differ from the frequency increase induced by ACh alone, and the ACh antagonist atropine left the response to HNP-1 intact. The specific opioid receptor antagonist naloxone (Nal) antagonized the inhibitory response evoked by HNP-1. The results obtained support the evidence for the recruitment of defensins in communication between the immune and nervous systems, and on the potential of sensory receptors to participate in the inflammatory response. (c) 2007 Elsevier B.V. All rights reserved.
C1 Russian Acad Sci, IP Pavlov Physiol Inst, Lab Physiol Recept, St Petersburg 199034, Russia.
RP Andrianov, GN (reprint author), Russian Acad Sci, IP Pavlov Physiol Inst, Lab Physiol Recept, Nab Makarova 6, St Petersburg 199034, Russia.
EM andryu@infran.ru
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NR 39
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 1
EP 8
DI 10.1016/j.heares.2007.05.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000001
PM 17606342
ER
PT J
AU Aarnisalo, AA
Pietola, L
Joensuu, J
Isosomppi, J
Aarnisalo, P
Dinculescu, A
Lewin, AS
Flannery, J
Hauswirth, WW
Sankila, EM
Jero, J
AF Aarnisalo, A. A.
Pietola, L.
Joensuu, J.
Isosomppi, J.
Aarnisalo, P.
Dinculescu, A.
Lewin, A. S.
Flannery, J.
Hauswirth, W. W.
Sankila, E.-M.
Jero, J.
TI Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse
cochlea
SO HEARING RESEARCH
LA English
DT Article
DE clarin-1; Usher type 3; organ of corti; apoptosis
ID SYNDROME TYPE-III; RECOMBINANT ADENOASSOCIATED VIRUS; GUINEA-PIG
COCHLEA; GENE-THERAPY; TRANSGENE EXPRESSION; PHOTORECEPTOR CELLS;
AUDITORY FUNCTION; CHROMOSOME 3Q; USH3 GENE; PROTEIN
AB Usher syndrome type 3 is caused by mutations in the USH3A gene, which encodes the protein clarin-1. Clarin-1 is a member of the tetraspanin superfamily (TM4SF) of transmembrane proteins, expressed in the organ of Corti and spiral ganglion cells of the mouse ear. We have examined whether the AAV-mediated anti-clarin ribozyme delivery causes apoptotic cell death in vivo in the organ of Corti. We used an AAV-2 vector delivered hammerhead ribozyme, AAV-CBA-Rz, which specifically recognizes and cleaves wild type mouse clarin-1 mRNA. Cochleae of CD-1 mice were injected either with 1 mu l of the AAV-CBA-Rz, or control AAV vectors containing the green fluorescent protein (GFP) marker gene (AAV-CBA-GFP). Additional controls were performed with saline only. At one-week and one-month post-injection, the animals were sacrificed and the cochleae were studied by histology and fluorescence imaging.
Mice injected with AAV-CBA-GFP displayed GFP reporter expression of varying fluorescence intensity throughout the length of the cochlea in the outer and inner hair cells and stria vascularis, and to a lesser extent, in vestibular epithelial cells. GFP expression was not detectable in the spiral ganglion. The pro-apoptotic effect of AAV-CBA-delivered anti-clarin-1 ribozymes was evaluated by TUNEL-staining. We observed in the AAV-CBA-Rz, AAV-CBA-GFP and saline control groups apoptotic nuclei in the outer and inner hair cells and in the stria vascularis one week after the microinjection. The vestibular epithelium was also observed to contain apoptotic cells. No TUNEL-positive spiral ganglion neurons were detected. After one-month post-injection, the AAV-CBA-Rz-injected group had significantly more apoptotic outer and inner hair cells and cells of the stria vascularis than the AAV-CBA-GFP group.
In this study, we demonstrate that AAV-CBA mediated clarin-1 ribozyme may induce apoptosis of the cochlear hair cells and cells of the stria vascularis. Surprisingly, we did not observe apoptosis in spiral ganglion cells, which should also be susceptible to clarin-1 mRNA cleavage. This result may be due to the injection technique, the promoter used, or tropism of the AAV serotype 2 viral vector. These results suggest the role of apoptosis in the progression of USH3A hearing loss warrants further evaluation. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Helsinki, Dept Otorhinolaryngol, Helsinki, Finland.
Biomed Helsinki Folkhalsan Inst Genet, Helsinki, Finland.
Univ Helsinki, Dept Clin Chem, SF-00100 Helsinki, Finland.
Univ Florida, Dept Ophthalmol & Mol Genet, Gainesville, FL USA.
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA.
Univ Helsinki, Dept Ophthalmol, Helsinki, Finland.
RP Aarnisalo, AA (reprint author), Univ Helsinki, Dept Otorhinolaryngol, Helsinki, Finland.
EM antti.aarnisalo@hus.fi
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NR 32
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 9
EP 16
DI 10.1016/j.heares.2007.03.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000002
PM 17493778
ER
PT J
AU Vieira, M
Christensen, BL
Wheeler, BC
Feng, AS
Kollmar, R
AF Vieira, Mauricio
Christensen, Barbara L.
Wheeler, Bruce C.
Feng, Albert S.
Kollmar, Richard
TI Survival and stimulation of neurite outgrowth in a serum-free culture of
spiral ganglion neurons from adult mice
SO HEARING RESEARCH
LA English
DT Article
DE adult; cell culture techniques; mice; neurites; neurons; spiral ganglion
ID VOLTAGE-DEPENDENT CURRENTS; AUDITORY NEURONS; IN-VITRO;
HIPPOCAMPAL-NEURONS; HAIR-CELLS; INNER-EAR; COCHLEA; MOUSE; NERVE;
NEUROTROPHINS
AB We have developed a reliable protocol for the serum-free dissociation and culture of spiral ganglion neurons from adult mice, an important animal model for patients with post-lingual hearing loss. Pilot experiments indicated that the viability of spiral ganglion cells in vitro depended critically on the use of Hibernate medium with B27 supplement. With an optimized protocol, we obtained 2 x 10(3) neurons immediately after dissociation, or about one-fifth of those present in the intact spiral ganglion. After four days in culture, 4% of the seeded neurons survived without any exogenous growth factors other than insulin. This yield was highly reproducible in five independent experiments and enabled us to measure systematically the numbers and lengths of the regenerating neurites. Furthermore, the survival rate compared well to the few published protocols for culturing adult spiral ganglion neurons from other species. Enhanced survival and neurite outgrowth upon the addition of brain-derived neurotrophic factor and leukemia inhibitory factor demonstrated that both are potent stimulants for damaged spiral ganglion neurons in adults. This responsiveness to exogenous growth factors suggested that our culture protocol will facilitate the screening of molecular compounds as potential treatments for sensorineural hearing loss. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA.
Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA.
Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA.
Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA.
RP Kollmar, R (reprint author), Univ Illinois, Dept Mol & Integrat Physiol, 407 S Goodwin Ave,MC-114, Urbana, IL 61801 USA.
EM vieira@uiuc.edu; bichris@uiuc.edu; bwheeler@uiuc.edu; afeng1@uiuc.edu;
rkollmar@uiuc.edu
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NR 49
TC 22
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 17
EP 23
DI 10.1016/j.heares.2007.03.005
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000003
PM 17521837
ER
PT J
AU Dai, C
Cheng, T
Wood, MW
Gan, RZ
AF Dai, Chenkal
Cheng, Tao
Wood, Mark W.
Gan, Rong Z.
TI Fixation and detachment of superior and anterior malleolar ligaments in
human middle ear: Experiment and modeling
SO HEARING RESEARCH
LA English
DT Article
DE middle ear ligament; laser interferometry; temporal bone; finite element
model; middle ear mechanics
ID MALLEUS FIXATION; DIAGNOSIS; SOUND
AB The aim of this study is to investigate the function of the superior malleolar ligament (SML) and the anterior malleolar ligament (AML) in human middle ear for sound transmission through simulations of fixation and detachment of these ligaments in human temporal bones and a finite element (FE) ear model. Two laser vibrometers were used to measure the vibrations of the tympanic membrane (TM) and stapes footplate. A 3-D FE ear model was used to predict the transfer function of the middle ear with ligament fixation and detachment. The results demonstrate that fixations and detachments of the SML and AML had different effects on TM and stapes footplate movements. Fixation of the SML resulted in a reduction of displacement of the TM (umbo) and the footplate at low frequencies (f < 1000 Hz), but also caused a shift of displacement peak to higher frequencies. Fixation of both SML and ANIL caused a reduction of 15 dB at umbo or stapes at low frequencies. Detachment of the SML had almost no effect on TM and footplate mobility, but AML detachment had a minor effect on TM and footplate movement. The FE model was able to predict the effects of SML and AML fixation and detachment. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Oklahoma, Sch Aerosp & Mech Engn, Norman, OK 73019 USA.
House Ear Res Inst, Oklahoma City, OK 73112 USA.
RP Gan, RZ (reprint author), Univ Oklahoma, Sch Aerosp & Mech Engn, 865 Asp Ave,Room 200, Norman, OK 73019 USA.
EM rgan@ou.edu
RI dai, chenkai/A-8051-2010
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NR 15
TC 14
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 24
EP 33
DI 10.1016/j.heares.2007.03.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000004
PM 17517484
ER
PT J
AU Lataye, R
Maguin, K
Campo, P
AF Lataye, Robert
Maguin, Katy
Campo, Pierre
TI Increase in cochlear microphonic potential after toluene administration
SO HEARING RESEARCH
LA English
DT Article
DE cochlear microphonic potential; toluene; solvent; auditory efferent
system
ID HAIR CELL-FUNCTION; OCCUPATIONAL EXPOSURE; HEARING FUNCTION;
GUINEA-PIGS; ALBINO-RAT; NOISE; STYRENE; OTOTOXICITY; GENTAMICIN;
METABOLISM
AB Human and animal studies have shown that toluene can cause hearing loss. In the rat, the outer hair cells are first disrupted by the ototoxicant. Because of their particular sensitivity to toluene, the cochlear microphonic potential (CMP) was used for monitoring the cochlea activity of anesthetized rats exposed to both noise (band noise centered at 4 kHz) and toluene. In the present experiment, the conditions were specifically designed to study the toluene effects on CMP and not those of its metabolites. To this end, 100-mu L injections of a vehicle containing different concentrations of solvent were made into the carotid artery connected to the tested cochlea. Interestingly, an injection of 116.2-mM toluene dramatically increased in the CMP amplitude (similar to 4 dB) in response to an 85-dB SPL noise. Moreover, the rise in CMP magnitude was intensity dependent at this concentration suggesting that toluene could inhibit the auditory efferent system involved in the inner-ear or/and middle-ear acoustic reflexes. Because acetylcholine is the neurotransmitter mediated by the auditory efferent bundles, injections of antagonists of cholinergic receptors (AchRs) such as atropine, 4-diphenylacetoxy-N-methylpiperidine-methiodide (mAchR antagonist) and dihydro-beta-erythroidine (nAchR antagonist) were also tested in this investigation. They all provoked rises in CMP having amplitudes as large as those obtained with toluene. The results showed for the first time in an in vivo study that toluene mimics the effects of AchR antagonists. It is likely that toluene might modify the response of protective acoustic reflexes. (c) 2007 Elsevier B.V. All rights reserved.
C1 Inst Natl Rech & Secur, Lab Neurotoxicite, F-54501 Vandoeuvre Les Nancy, France.
RP Campo, P (reprint author), Inst Natl Rech & Secur, Lab Neurotoxicite, Ave Bourgogne,BP 27, F-54501 Vandoeuvre Les Nancy, France.
EM Pierre.campo@mrs.fr
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NR 37
TC 14
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 34
EP 42
DI 10.1016/j.heares.2007.04.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000005
PM 17555896
ER
PT J
AU Roehm, P
Hoffer, M
Balaban, CD
AF Roehm, Pamela
Hoffer, Michael
Balaban, Carey D.
TI Gentamicin uptake in the chinchilla inner ear
SO HEARING RESEARCH
LA English
DT Article
DE spiral ganglion; vestibular ganglion; cochlear aqueduct; transtympanic
gentamicin; uptake
ID VESTIBULAR HAIR-CELLS; COCHLEAR GENE-TRANSFER; ADENOASSOCIATED VIRUS;
GUINEA-PIGS; KANAMYCIN CHALLENGE; DEPENDENT RESPONSE; SPIRAL GANGLION;
AMINOGLYCOSIDES; STREPTOMYCIN; OTOTOXICITY
AB Studies of transtympanic gentamicin have focused oil clinical use and outcomes. This study presents evidence of bilateral uptake and retention of gentamicin in certain inner ear cells and structures following transtympanic gentamicin application. Middle ear application of gentamicin was performed by either minipump (Alza model, 2002) or transtympanic injection in a chinchilla model. Histological sections of decalcified temporal bones were stained to identify the distribution of gentamicin. Using both anti-gentamicin immunohistochemistry and autoradiography of tracer amounts of tritiated gentamicin, Scarpa's and spiral ganglion cells, stria vascularis, and vestibular dark cells of the injected ear were found to have higher levels of gentamicin and retain it within cell bodies while staining levels fell to background levels in the rest of the injected ear over the course of 14 days. There was no evidence of an apical to basal gradient of anti-gentamicin staining within the spiral ganglion. Contralateral inner ear cells showed light anti-gentamicin staining. Cell bodies in the ipsilateral dorsal cochlear nucleus bordering tile cochlear aqueduct (CA) showed a lateral to medial gradient of gentamicin staining, suggesting the CA as a potential site of transfer of gentamicin to the contralateral ear. Direct effects of aminoglycosides oil ganglion cells may have implications oil both the success of cochlear implantation in patients deafened following systemic aminoglycoside therapy and oil the advisability of clinical practices of transtympanic gentamicin therapy and ototopic aminoglycoside treatment. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Pittsburgh, Sch Med, Dept Otolaryngol, Pittsburgh, PA 15213 USA.
NYU, Sch Med, Dept Otolaryngol, New York, NY 10003 USA.
Natl Naval Med Ctr, Dept Otolaryngol, Bethesda, MD USA.
Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15213 USA.
Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA 15213 USA.
Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15213 USA.
RP Balaban, CD (reprint author), Univ Pittsburgh, Sch Med, Dept Otolaryngol, 107 Eye & Ear Inst,203Lothrop St, Pittsburgh, PA 15213 USA.
EM cbalaban@pitt.edu
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NR 36
TC 16
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 43
EP 52
DI 10.1016/j.heares.2007.04.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000006
PM 17616288
ER
PT J
AU Mckay, SM
Oleskevich, S
AF Mckay, Sarah M.
Oleskevich, Sharon
TI The role of spontaneous activity in development of the endbulb of Held
synapse
SO HEARING RESEARCH
LA English
DT Article
DE endbulb of held; auditory; development; AMPA; dn/dn; spontaneous
ID ANTEROVENTRAL COCHLEAR NUCLEUS; AUDITORY BRAIN-STEM; CONGENITALLY DEAF
MICE; RELEASE PROBABILITY; POSTSYNAPTIC EXPRESSION; HOMEOSTATIC
PLASTICITY; HEARING-LOSS; BUSHY CELLS; TIME-COURSE; NEURONS
AB In the mouse brainstem cochlear nucleus, the auditory nerve to bushy cell synapse (endbulb of Held) is specialised for rapid, high-fidelity transmission. Development of this synapse is modulated by auditory nerve activity. Here we investigate the role of spontaneous auditory nerve activity in synaptic transmission using deafness (dn/dn) mutant mice that have abnormal hair cells and lack spontaneous auditory nerve activity. Evoked and miniature alpha amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor-mediated excitatory post-synaptic currents (eEPSCs, mEPSCs) were compared in deafness and normal mice before the age of hearing onset (postnatal day 7-11: P7-11) using variance-mean, miniature event and tetanic depression analyses. Amplitudes were significantly greater in deafness mice for eEPSCs (2.1-fold), mEPSCs (1.4-fold) and quantal amplitudes (1.5-fold). eEPSCs in deafness mice decayed more rapidly with increasing age, indicating an input-independent transition in post-synaptic AMPA receptor properties. A comparison of normal mice before and after the onset of hearing showed a change in synaptic parameters with an increase in eEPSC (1.7-fold), mEPSC (1.6-fold) and quantal amplitude (1.7-fold) after hearing onset while release probability remained constant (0.5). Overall, the results in deafness mice suggest that synaptic strength is altered in the absence of spontaneous auditory nerve activity. Crown Copyright (c) 2007 Published by Elsevier B.V. All rights reserved.
C1 Garvan Inst Med Res, Neurosci Res Program, Sydney, NSW 2010, Australia.
Univ New S Wales, Sydney, NSW 2052, Australia.
RP Oleskevich, S (reprint author), Garvan Inst Med Res, Neurosci Res Program, Sydney, NSW 2010, Australia.
EM s.mckay@garvan.org.au; s.oleskevich@garvan.org.au
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NR 58
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 53
EP 63
DI 10.1016/j.heares.2007.05.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000007
PM 17590547
ER
PT J
AU Ries, DT
DiGiovanni, JJ
AF Ries, Dennis T.
DiGiovanni, Jeffery J.
TI Release from interference in auditory working memory for pitch
SO HEARING RESEARCH
LA English
DT Article
DE pitch; difference limen; auditory; working memory; frequency
ID SHORT-TERM-MEMORY; INTERAURAL TIME DIFFERENCES; RECOGNITION MEMORY;
OCTAVE-ILLUSION; RETROACTIVE INTERFERENCE; PREFRONTAL CORTEX; TONAL
PITCH; TONES; ATTENTION; EAR
AB The purpose of this study was to quantify the effect of interpolated tones upon a pitch standard held within auditory working memory through measurement of the difference limen Oust noticeable difference) for frequency and the usefulness of "Where" cues to ameliorate the interference produced by these intervening stimuli. To this end, we measured the degree to which tones, containing identical and disparate localization cues, presented within the retention interval altered differential sensitivity for frequency via the method of constant stimuli. The difference limen for frequency nearly tripled when tones were presented within the retention interval and sound localization cues produced a significant partial release from interference within the short-term pitch store. Interference produced by "Where" cues ranged from 4.0 to 5.2 Hz. These findings indicate that there is a possible integrative use of the "What" and "Where" pathways in forming and maintaining pitch information within the pitch array within auditory working memory. (c) 2007 Elsevier B.V. All rights reserved.
C1 Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W241, Auditory Precept Lab, Athens, OH 45701 USA.
Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W151a, Auditory Psychophys & Signal Proc Lab, Athens, OH 45701 USA.
RP Ries, DT (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W221, Athens, OH 45701 USA.
EM ries@ohio.edu; digiovan@ohio.edu
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NR 47
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 64
EP 72
DI 10.1016/j.heares.2007.04.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000008
PM 17574355
ER
PT J
AU Thornton, ARD
Harmer, M
Lavoie, BA
AF Thornton, A. Roger D.
Harmer, Matthew
Lavoie, Brigitte A.
TI Selective attention increases the temporal precision of the auditory
N-100 event-related potential
SO HEARING RESEARCH
LA English
DT Article
DE correlation; latency jitter; neural dynamics; single trial;
synchronization
ID CAT VISUAL-CORTEX; ADAPTIVE FILTER; RESPONSES; CHILDREN; OSCILLATIONS;
MODULATION; DYNAMICS; ADULTS
AB Selective attention increases the amplitude of the averaged N-100 event-related potential (ERP). This increase may result from more neurons responding to the stimulus or from the same number of neurons better synchronised with the stimulus, or both. We investigated the synchronization mechanism using a new response latency jitter measurement algorithm that performed well for all the signal-to-noise ratios obtained in the experiment. We found that the significantly increased N100 amplitude is accounted for by a significantly decreased latency jitter variance for the attended stimuli. (c) 2007 Elsevier B.V. All rights reserved.
C1 Royal S Hants Hosp, MRC Inst Hearing Res, Southampton SO14 0YG, Hants, England.
Univ Southampton, Southampton SO9 5NH, Hants, England.
RP Thornton, ARD (reprint author), Royal S Hants Hosp, MRC Inst Hearing Res, Southampton SO14 0YG, Hants, England.
EM ardt@soton.ac.uk
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NR 26
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 73
EP 79
DI 10.1016/j.heares.2007.04.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000009
PM 17606341
ER
PT J
AU Sucher, CM
McDermott, HJ
AF Sucher, Catherine M.
McDermott, Hugh J.
TI Pitch ranking of complex tones by normally hearing subjects and cochlear
implant users
SO HEARING RESEARCH
LA English
DT Article
DE pitch perception; cochlear implants; normal hearing
ID MUSIC PERCEPTION; ELECTRIC HEARING; TEMPORAL PITCH; STIMULATION;
RECOGNITION; DIMENSIONS; RECIPIENTS; INTERVAL; TIMBRE; LISTENERS
AB The ability of 10 normally hearing (NH) adults and eight cochlear implant (CI) users to pitch-rank pairs of complex tones was assessed. The acoustically presented stimuli differed in fundamental frequency (F0) by either one or six semitones (F0 range: 98 to 740 Hz). The NH group obtained significantly higher mean scores for both experiments: (NH: one semitone - 81.2%, six semitones 89.0%; CI: one semitone - 49.0%, six semitones - 60.2%; p < 0.001). Prior musical experience was found to be associated with higher pitch-ranking scores for the NH subjects. Those with musical experience ratings <3 obtained significantly lower scores for both interval sizes (p < 0.001) than those with higher ratings. Nevertheless, the scores obtained by the musically inexperienced, NH adults were significantly higher than those obtained by the CI group for both the one-semitone (p = 0.022) and six-semitone (p = 0.0 18) intervals. These results suggest that the pitch information CI users obtain from their implant systems is less accurate than that obtained by NH listeners when listening to the same complex sounds. Furthermore, the relatively poor pitch-ranking ability of at least some CI users may be associated with a more-limited experience of music in general. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Sucher, CM (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM csucher@bionicear.org; hughm@unimelb.edu.au
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NR 37
TC 23
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 80
EP 87
DI 10.1016/j.heares.2007.05.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000010
PM 17604582
ER
PT J
AU Fakhry, N
Rostain, JC
Cazals, Y
AF Fakhry, Nicolas
Rostain, Jean Claude
Cazals, Yves
TI Hyperbaric oxygenation with corticoid in experimental acoustic trauma
SO HEARING RESEARCH
LA English
DT Article
DE acute acoustic trauma; hearing loss; hyperbaric oxygen; corticoid;
guinea pigs
ID INDUCED HEARING-LOSS; PIG INNER-EAR; THERAPY; METHYLPREDNISOLONE
AB Among possible therapies after acute acoustic trauma, hyperbaric oxygenation (HBO) combined with corticoid was found effective in several animal studies. Such evidence was obtained for moderate 20-25 dB losses. The aim of this study was to further assess this therapy for noise-induced hearing losses greater than previously examined. Sixty-five ears from thirty-six adult guinea pigs were used. Acoustically evoked responses from intracranial electrodes chronically implanted bilaterally into the ventral cochlear nucleus were used to assess acoustic sensitivity alterations. Trauma sound was a third-octave noise-band around 8 kHz presented bilaterally at 115 dB SPL for 45 min. One control group received no treatment, one group was treated with HBO only and another with corticoid only both starting within one day post-trauma, two groups were treated with both HBO and corticoid starting for one group within one day post-trauma, and for the second group at 6 days post-trauma. Acoustic thresholds were measured between the 6th and the 16th days after acoustic trauma. Animals treated with HBO alone or corticoid alone did not differ from controls. Combined HBO and corticoid therapy provided significant protection from noise-induced loss of auditory thresholds, especially when started one day post-exposure. Hearing loss reduction induced by HBO combined with corticoid was of similar magnitude (about 10-15 dB) as in previous studies although the induced hearing loss was considerably greater (about 40 dB instead of 20-25 dB). (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ P Cezanne, Fac Sci & Tech, CNRS, UMR 6153,Lab Physiol Neurovegetat, F-13397 Marseille 20, France.
Univ CHU La Timone, Ctr Hosp, Serv ORL & Chirurg Cervico Faciale, F-13385 Marseille, France.
Univ Aix Marseille 2, EA 3280, Lab Physiopathol & Therapeut Gaz Press, F-13916 Marseille 20, France.
IMNSSA, Fac Med Nord, F-13916 Marseille 20, France.
RP Cazals, Y (reprint author), Univ P Cezanne, Fac Sci & Tech, CNRS, UMR 6153,Lab Physiol Neurovegetat, Campus St Jerome,Ave Normandie Niemen, F-13397 Marseille 20, France.
EM yves.cazals@univ-cezanne.fr
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NR 19
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2007
VL 230
IS 1-2
BP 88
EP 92
DI 10.1016/j.heares.2007.05.005
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 203KH
UT WOS:000248973000011
PM 17590548
ER
PT J
AU Winer, JA
Lee, CC
AF Winer, Jeffery A.
Lee, Charles C.
TI The distribution auditory cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE auditory cortex; parallel processing; thalamocortical; corticothalamic;
corticofugal
ID MEDIAL GENICULATE-BODY; POSTERIOR ECTOSYLVIAN GYRUS; LARGE BASKET CELLS;
INFERIOR COLLICULUS; AXON TERMINALS; VISUAL-CORTEX;
FUNCTIONAL-ORGANIZATION; TONOTOPIC ORGANIZATION; MODULAR ORGANIZATION;
CORTICAL PROJECTIONS
AB A synthesis of cat auditory cortex (AC) organization is presented in which the extrinsic and intrinsic connections interact to derive a unified profile of the auditory stream and use it to direct and modify cortical and subcortical information flow. Thus. file thalamocortical input provides essential sensory information about peripheral stimulus events, which AC redirects locally for feature extraction. and then conveys to parallel auditory, multisensory, premotor, limbic, and cognitive centers for further analysis. The corticofugal output influences areas as remote as the pons and the cochlear nucleus. Structures whose effects upon AC are entirely indirect, and it has diverse roles in the transmission of information through the medial geniculate body and inferior colliculus. The distributed AC is thus construed as a functional network in which the auditory percept is assembled for Subsequent redistribution in sensory, premotor, and cognitive streams contingent on the derived interpretation of the acoustic events. The confluence of auditory and multisensory streams likely precedes cognitive processing of sound. The distributed AC constitutes the largest and arguably the most complete representation of the auditory world. Many facets of this scheme may apply in rodent and primate AC as well. We propose that the distributed auditory cortex contributes to local processing regimes in regions as disparate as the frontal pole and the cochlear nucleus to construct the acoustic percept. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Calif Berkeley, Div Neurobiol, Dept Mol & Cell Biol, Berkeley, CA 94720 USA.
RP Winer, JA (reprint author), Univ Calif Berkeley, Div Neurobiol, Dept Mol & Cell Biol, Room 289, Berkeley, CA 94720 USA.
EM jaw@berkeley.edu
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NR 104
TC 72
Z9 72
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 3
EP 13
DI 10.1016/j.heares.2007.01.017
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100002
PM 17329049
ER
PT J
AU Poremba, A
Mishkin, M
AF Poremba, Amy
Mishkin, Mortimer
TI Exploring the extent and function of higher-order auditory cortex in
rhesus monkeys
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC Inst Hearing Res
DE monkey; vocalization; lateralization; multisensory; temporal pole;
superior temporal gyrus
ID SUPERIOR TEMPORAL SULCUS; PRIMATE PREFRONTAL CORTEX; CORTICAL
CONNECTIONS; MACAQUE MONKEYS; WORKING-MEMORY; COMPLEX SOUNDS; VISUAL
AREAS; NEURONS; REPRESENTATION; SUBDIVISIONS
AB Just as cortical visual processing continues far beyond the boundaries of early visual areas, so too does cortical auditory processing continue far beyond the limits of early auditory areas. In passively listening rhesus monkeys examined with metabolic mapping techniques. cortical areas reactive to auditory stimulation were found to include the entire length of the superior temporal gyrus (STG) as well as several other regions within the temporal, parietal, and frontal lobes. Comparison of these widespread activations with those from an analogous study in vision Supports the notion that audition, like vision, is served by several cortical processing streams, each specialized for analyzing a different aspect of sensory input, such as stimulus quality, location, or motion. Exploration with different classes of acoustic stimuli demonstrated that most portions of STG show greater activation on the right than on the left regardless of stimulus class. However, there is a striking shift to left-hemisphere "dominance" during passive listening to species-specific vocalizations, though this reverse asymmetry is observed only in the region of temporal pole. The mechanism for this left temporal pole "dominance'" appears to be suppression of the right temporal pole by the left hemisphere, as demonstrated by a comparison of the results in normal monkeys with those in split-brain monkeys. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Iowa, Dept Psychol, Iowa City, IA 52240 USA.
NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA.
RP Poremba, A (reprint author), Univ Iowa, Dept Psychol, E124 SSH, Iowa City, IA 52240 USA.
EM amy-poremba@uiowa.edu; mm@ln.nimh.nih.gov
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NR 54
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 14
EP 23
DI 10.1016/j.heares.2007.01.003
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100003
PM 17321703
ER
PT J
AU Zatorre, RJ
AF Zatorre, Robert J.
TI There's more to auditory cortex than meets the ear
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE functional neuroimaging
ID SELECTIVE ATTENTION; SPEECH-PERCEPTION; MUSICAL IMAGERY; VISUAL EVENTS;
MODULATION; PLASTICITY; MEMORY; BRAIN; EXPERIENCE; STIMULI
AB The auditory cortex is typically defined as that portion of the cortex containing neurons that respond to sound. This definition is adequate in a narrow context, but does not take into account sufficiently the subtleties associated with more complex behaviors and cognitive processes. Thus, it is easy to demonstrate that cortical regions essentially unrelated to sound processing may nevertheless be activated by an auditory stimulus; conversely, it is possible to demonstrate responses within classical auditory cortical regions in the complete absence of sound. We give several examples that indicate that responses in auditory cortex cannot be predicted based solely on knowledge of stimulus features. Rather, factors such as memory, attention, and mental imagery can be shown to play a major role in modulating or producing neural responses within auditory cortex. We argue that the interactions between classically defined auditory regions and other sensory, motor, and cognitive systems underlie many behaviors of interest; and that a more complete understanding of these processes will emerge from a consideration of the distributed nature of auditory cortical function. (c) 2007 Elsevier B.V. All rights reserved.
C1 McGill Univ, Montreal Neurol Inst, BRAMS Lab, Montreal, PQ, Canada.
RP Zatorre, RJ (reprint author), McGill Univ, Montreal Neurol Inst, BRAMS Lab, Montreal, PQ, Canada.
EM robert.zatorre@mcgill.ca
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NR 39
TC 19
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 24
EP 30
DI 10.1016/j.heares.2007.01.018
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100004
PM 17341441
ER
PT J
AU Lomber, SG
Malhotra, S
Hall, AJ
AF Lomber, Stephen G.
Malhotra, Shveta
Hall, Amee J.
TI Functional specialization in non-primary auditory cortex of the cat:
Areal and laminar contributions to sound localization
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE reversible deactivation; superior colliculus; posterior auditory field;
dorsal zone; anterior ectosylvian sulcus
ID ANTERIOR ECTOSYLVIAN SULCUS; SUPERIOR COLLICULUS; CEREBRAL-CORTEX;
COOLING DEACTIVATION; UNILATERAL ABLATION; RESPONSE PROPERTIES;
CORTICAL-NEURONS; RETINOTOPIC ORGANIZATION; SPATIAL SENSITIVITY;
CORTICOTECTAL CELLS
AB The purpose of this study is to: (1) examine the relative contributions of the 13 acoustically-responsive regions of the cerebral cortex to sound localization: (2) examine the laminar contributions to spatial localization behavior for each of the cortical areas identified to be critical for accurately determining the position of a sound source: and (3) synthesize the findings from sound localization studies and the underlying corticocortical and corticotectal connections to develop a processing system for Sound localization information within and between the cerebral cortex and the superior colliculus. First, we examined performance on a sound localization task before, during, and after unilateral or bilateral reversible cooling deactivation of each region of acoustically-responsive cortex. Overall, unilateral deactivation of primary auditory cortex and the dorsal zone (AI/DZ), the posterior auditory field (PAF). or the auditory field of the anterior ectosylvian sulcus (AES) yielded profound sound localization deficits in the contralateral field. Bilateral deactivations of the same regions yielded bilateral sound localization deficits. Second, graded cooling of AI/DZ or PAF showed that deactivation of only the superficial layers was required to elicit Sound localization deficits. However. graded cooling of AES revealed that cooling of the superficial layers alone does not cause significant sound localization deficits. Profound deficits were identified only when cooling extended through the full thickness of AES cortex. Therefore. we propose that the superficial layers of AI/DZ or PAF and the deeper layers of AES are necessary for determining the precise location of a sound source. Finally, when these results are combined with data on corticocortical and corticotectal projections, we propose that signals processed in the superficial layers of AI, DZ, or PAF feed forward to the auditory field of AES. In turn. neurons ill the deeper layers of AES project to the intermediate and deeper layers of the superior colliculus. Therefore. we propose that sound localization signals processed in primary and non-primary auditory cortex are transmitted to the superior colliculus by means of the auditory field of the AES. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Western Ontario, Dept Physiol & Pharmacol, Ctr Brain & Mind, London, ON N6A 5K8, Canada.
Univ Western Ontario, Dept Psychol, N London, ON N6A 5C2, Canada.
RP Lomber, SG (reprint author), Univ Western Ontario, Dept Physiol & Pharmacol, Ctr Brain & Mind, 100 Perth Dr, London, ON N6A 5K8, Canada.
EM steve.lomber@uwo.ca
RI Lomber, Stephen/B-6820-2015
OI Lomber, Stephen/0000-0002-3001-7909
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NR 88
TC 31
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 31
EP 45
DI 10.1016/j.heares.2007.01.013
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100005
PM 17329050
ER
PT J
AU Griffiths, TD
Kumar, S
Warren, JD
Stewart, L
Stephan, KE
Friston, KJ
AF Griffiths, Timothy D.
Kumar, Sukhbinder
Warren, Jason D.
Stewart, Lauren
Stephan, Klaas Enno
Friston, Karl J.
TI Approaches to the cortical analysis of auditory objects
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC Inst Hearing Res
DE auditory cortex; functional imaging; neurology; lesion
ID MODEL SELECTION; BALLOON MODEL; CORTEX; BRAIN; FMRI; RESPONSES; MUSIC;
AREAS; PITCH
AB We describe work that addresses the cortical basis for the analysis of auditory objects using 'generic' sounds that do not correspond to any particular events or sources (like vowels or voices) that have semantic association. The experiments involve the manipulation of synthetic sounds to produce systematic changes of stimulus features, such as spectral envelope.
Conventional analyses of normal functional imaging data demonstrate that the analysis of spectral envelope and perceived timbral change involves a network consisting of planum temporale (PT) bilaterally and the right superior temporal sulcus (STS). Further analysis of imaging data using dynamic causal modelling (DCM) and Bayesian model selection was carried out in the right hemisphere areas to determine the effective connectivity between these auditory areas. Specifically, the objective was to determine if the analysis of spectral envelope in the network is done in a serial fashion (that is from HG to PT to STS) or parallel fashion (that is PT and STS receives input from HG simultaneously). Two families of models, serial and parallel (16 in total) that represent different hypotheses about the connectivity between HG, PT and STS were selected. The models within a family differ with respect to the pathway that is modulated by the analysis of spectral envelope. After the models are identified, Bayesian model selection procedure is then used to select the 'optimal' model from the specified models. The data strongly support a particular serial model containing modulation of the HG to PT effective connectivity during spectral envelope variation.
Parallel work in neurological subjects addresses the effect of lesions to different parts of this network. We have recently studied in detail subjects with 'dystimbria': an alteration in the perceived quality of auditory objects distinct from pitch or loudness change. The subjects have lesions of the normal network described above with normal perception of pitch strength but abnormal perception of the analysis of spectral envelope change. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Newcastle Upon Tyne, Sch Med, Auditory Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
UCL, Inst Neurol, Wellcome Dept Imaging Neurosci, London WC1N 6BT, England.
RP Griffiths, TD (reprint author), Univ Newcastle Upon Tyne, Sch Med, Auditory Grp, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
EM t.d.griffiths@ncl.ac.uk
RI Friston, Karl/D-9230-2011
OI Friston, Karl/0000-0001-7984-8909
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NR 26
TC 12
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 46
EP 53
DI 10.1016/j.heares.2007.01.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100006
PM 17321704
ER
PT J
AU Weinberger, NM
AF Weinberger, Norman M.
TI Auditory associative memory and representational plasticity in the
primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE acetylcholine; conditioning; receptive field
ID RECEPTIVE-FIELD PLASTICITY; MEDIAL GENICULATE-NUCLEUS; LEARNING-INDUCED
PLASTICITY; TONE-EVOKED RESPONSES; BASAL FOREBRAIN; GUINEA-PIG;
CHOLINERGIC MODULATION; SINGLE NEURONS; FREQUENCY DISCRIMINATION;
PHYSIOLOGICAL PLASTICITY
AB Historically. the primary auditory cortex has been largely ignored as a substrate of auditory memory, perhaps because studies of associative learning Could not reveal the plasticity of receptive fields (RFs). The use of a unified experimental design, in which RFs are obtained before and after standard training (e.g., classical and instrumental conditioning) revealed associative representational plasticity, characterized by facilitation of responses to tonal conditioned stimuli (CSs) at the expense of other frequencies, producing CS-specific tuning shifts. Associative representational plasticity (ARP) possesses the major attributes of associative memory: it is highly specific, discriminative, rapidly acquired, consolidates over hours and days and can be retained indefinitely. The nucleus basalis cholinergic system is sufficient both For the induction of ARP and for the induction of specific auditory memory, including control of the amount of remembered acoustic details. Extant controversies regarding the form. function and neural substrates of ARP appear largely to reflect different assumptions, which are explicitly discussed. The view that the forms of plasticity are task dependent is supported by ongoing studies in which auditory learning involves CS-specific decreases in threshold or bandwidth without affecting frequency tuning. Future research needs to focus on the factors that determine ARP and their functions in hearing and in auditory memory. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Neurobiol & Behav, Ctr Neurobiol Learning & Memory, Irvine, CA 92797 USA.
RP Weinberger, NM (reprint author), Univ Calif Irvine, Dept Neurobiol & Behav, Ctr Neurobiol Learning & Memory, Irvine, CA 92797 USA.
EM nmweinbe@uci.edu
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NR 80
TC 81
Z9 83
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 54
EP 68
DI 10.1016/j.heares.2007.01.004
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100007
PM 17344002
ER
PT J
AU Eggermont, JJ
AF Eggermont, Jos J.
TI Correlated neural activity as the driving force for functional changes
in auditory cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE electrode arrays; spectro-temporal receptive field; coincidence
detection; cat; plasticity
ID CAT VISUAL-CORTEX; ENRICHED ACOUSTIC ENVIRONMENT; NEOCORTICAL PYRAMIDAL
NEURONS; RECEPTIVE-FIELD PROPERTIES; INDUCED HEARING-LOSS; MONKEY MOTOR
CORTEX; PRECISION GRIP TASK; VOICE ONSET TIME; CROSS-CORRELATION; NOISE
TRAUMA
AB The functional role of neural synchrony is reflected in cortical tonotopic map reorganization and in the emergence of pathological phenomena such as tinnitus. First of all experimenter-centered and subject-centered views of neural activity will be contrasted; this argues against the use of stimulus-correction procedures and favors the use of a correction procedure based on neural activity without reference to stimulus timing. Within a cortical column neurons fired synchronously with on average about 6 % of their spikes in a 1 ms bin and occasionally showing 30 % or more of such coincident spikes. For electrode separations exceeding 200 mu m the average peak correlation strength only occasionally reached 3 %. The experimental evidence for coincidence of neural activity, neural correlation and neural synchrony shows that horizontal fibers activity can induce strong neural correlations. Cortico- cortical connections for a large part connect cell groups with characteristic frequencies differing by more than one octave. Such neurons have generally non-overlapping receptive fields but still can have sizeable peak cross-correlations. Correlated neural activity and heterotopic neural interconnections are presented as the substrates for cortical reorganization; increased neural synchrony and tonotopic map reorganization go hand in hand. This links cortical reorganization with hypersynchrony that can be considered as an important driving force underlying tinnitus. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Calgary, Dept Phys & Biophys, Calgary, AB T2N 1N4, Canada.
Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Phys & Biophys, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM eggermon@ucalgary.ca
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NR 89
TC 38
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 69
EP 80
DI 10.1016/j.heares.2007.01.008
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100008
PM 17296278
ER
PT J
AU Wang, XQ
AF Wang, Xiaoqin
TI Neural coding strategies in auditory cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE auditor cortex; marmoset; temporal processing; neural coding
ID AMPLITUDE-MODULATED SOUNDS; MEDIAL GENICULATE-BODY; ANTEROVENTRAL
COCHLEAR NUCLEUS; CALLITHRIX-JACCHUS-JACCHUS; SINGLE-FORMANT STIMULI;
PHASE-LOCKED RESPONSES; CORTICAL-NEURONS; INFERIOR COLLICULUS; NERVE
FIBERS; COMMON MARMOSET
AB In contrast to the visual system, the auditory system has longer subcortical pathways and more spiking synapses between the peripheral receptors and the cortex. This unique organization reflects the needs of the auditory system to extract behaviorally relevant information from a complex acoustic environment using strategies different from those used by other sensory systems. The neural representations of acoustic information in auditory cortex can be characterized by three types: (1) isomorphic (faithful) representations of acoustic structures; (2) non-isomorphic transformations of acoustic features and (3) transformations from acoustical to perceptual dimensions. The challenge facing auditory neurophysiologists is to understand the nature of the latter two transformations. In this article, I will review recent Studies front our laboratory regarding temporal discharge patterns in auditory cortex of awake marmosets and cortical representations of time-varying signals. Findings from these studies show that (1) firing patterns of neurons in auditory cortex are dependent on stimulus optimality and context and (2) the auditory cortex forms internal representations of sounds that are no longer faithful replicas of their acoustic structures. (c) 2007 Published by Elsevier B.V.
C1 Johns Hopkins Univ, Sch Med, Lab Auditory Neurophysiol, Dept Biomed Engn, Baltimore, MD 21205 USA.
RP Wang, XQ (reprint author), Johns Hopkins Univ, Sch Med, Lab Auditory Neurophysiol, Dept Biomed Engn, 720 Rutland Ave,Traylor 410, Baltimore, MD 21205 USA.
EM xiaoqin.wang@jhu.edu
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NR 69
TC 45
Z9 47
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 81
EP 93
DI 10.1016/j.heares.2007.01.019
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100009
PM 17346911
ER
PT J
AU Nelken, I
Chechik, G
AF Nelken, Israel
Chechik, Gal
TI Information theory in auditory research
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE auditory system; information theory; entropy; mutual information;
variance decomposition; neural code
ID INFERIOR COLLICULUS; POPULATION CODES; NEURONS; RESPONSES; CORTEX; TIME;
TRANSMISSION; REDUNDANCY; STIMULI; CAT
AB Mutual information (MI) is in increasing use as a way of quantifying neural responses. However, it is still considered with some doubts by many researchers, because it is not always clear what MI really measures. and because MI is hard to calculate in practice. This paper aims to clarify these issues. First, it provides an interpretation of mutual information as variability decomposition, similar to standard variance decomposition routinely used in statistical evaluations of neural data, except that the measure of variability is entropy rather than variance. Second, it discusses those aspects of the MI that makes its calculation difficult. The goal of this paper is to clarify when and how information theory can be used informatively and reliably in auditory neuroscience. (c) 2007 Elsevier B.V. All rights reserved.
C1 Hebrew Univ Jerusalem, Dept Neurobiol, Silberman Inst Life Sci, IL-91904 Jerusalem, Israel.
Hebrew Univ Jerusalem, Interdisciplinary Ctr Neural Computat, Silberman Inst Life Sci, IL-91904 Jerusalem, Israel.
Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.
RP Nelken, I (reprint author), Hebrew Univ Jerusalem, Dept Neurobiol, Silberman Inst Life Sci, Safra Campus, IL-91904 Jerusalem, Israel.
EM israel@cc.huji.ac.il
RI Nelken, Israel/B-7753-2011
OI Nelken, Israel/0000-0002-6645-107X
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NR 27
TC 27
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 94
EP 105
DI 10.1016/j.heares.2007.01.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100010
PM 17300891
ER
PT J
AU King, AJ
Bajo, VM
Bizley, JK
Campbell, RAA
Nodal, FR
Schulz, AL
Schnupp, JWH
AF King, Andrew J.
Bajo, Victoria M.
Bizley, Jennifer K.
Campbell, Robert A. A.
Nodal, Fernando R.
Schulz, Andreas L.
Schnupp, Jan W. H.
TI Physiological and behavioral studies of spatial coding in the auditory
cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC Inst Hearing Res
DE auditory localization; ferret; reversible inactivation; corticofugal
pathway; virtual acoustic space; binaural; plasticity; training
ID SOUND-LOCALIZATION BEHAVIOR; EAR TRANSFER-FUNCTIONS;
INDIVIDUAL-DIFFERENCES; INDUCED PLASTICITY; CORTICAL-NEURONS; PRESSURE
LEVEL; CAT; SPACE; CUES; SENSITIVITY
AB Despite extensive subcortical processing, the auditory cortex is believed to be essential for normal sound localization. However, we still have a poor understanding of how auditory spatial information is encoded in the cortex and of the relative contribution of different cortical areas to spatial hearing. We investigated the behavioral consequences of inactivating ferret primary auditory cortex (A1) on auditory localization by implanting a sustained release polymer containing the GABA(A) agonist muscimol bilaterally over A1. Silencing A1 led to a reversible deficit in the localization of brief noise bursts in both the horizontal and vertical planes. In other ferrets, large bilateral lesions of the auditory cortex, which extended beyond A1, produced more severe and persistent localization deficits.
To investigate the processing of spatial information by high-frequency A1 neurons, we measured their binaural-level functions and used individualized virtual acoustic space stimuli to record their spatial receptive fields (SRFs) in anesthetized ferrets. We observed the existence of a continuum of response properties, with most neurons preferring contralateral sound locations. In many cases, the SRFs could be explained by a simple linear interaction between the acoustical properties of the head and external ears and the binaural frequency tuning of the neurons. Azimuth response profiles recorded in awake ferrets were very similar and further analysis suggested that the slopes of these functions and location-dependent variations in spike timing are the main information-bearing parameters.
Studies of sensory plasticity can also provide valuable insights into the role of different brain areas and the way in which information is represented within them. For example, stimulus-specific training allows accurate auditory localization by adult ferrets to be relearned after manipulating binaural cues by occluding one ear. Reversible inactivation of A1 resulted in slower and less complete adaptation than in normal controls, whereas selective lesions of the descending corticocollicular pathway prevented any improvement in performance. These results reveal a role for auditory cortex in training-induced plasticity of auditory localization, which could be mediated by descending cortical pathways. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England.
RP King, AJ (reprint author), Univ Oxford, Dept Physiol Anat & Genet, Sherrington Bldg,Pk Rd, Oxford OX1 3PT, England.
EM andrew.king@physiol.ox.ac.uk
RI schnupp, jan/A-3006-2012; King, Andrew/M-6708-2013
OI King, Andrew/0000-0001-5180-7179
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NR 57
TC 41
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 106
EP 115
DI 10.1016/j.heares.2007.01.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100011
PM 17314017
ER
PT J
AU Micheyl, C
Carlyon, RP
Gutschalk, A
Melcher, JR
Oxenham, AJ
Rauschecker, JP
Tian, B
Wilson, EC
AF Micheyl, Christophe
Carlyon, Robert P.
Gutschalk, Alexander
Melcher, Jennifer R.
Oxenham, Andrew J.
Rauschecker, Josef P.
Tian, Biao
Wilson, E. Courtenay
TI The role of auditory cortex in the formation of auditory streams
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC Inst Hearing Res
DE auditory cortex; auditory scene analysis; single-unit recordings;
magnetoencephalography; functional magnetic resonance imaging
ID STARLINGS STURNUS-VULGARIS; GOLDFISH CARASSIUS-AURATUS; MIDDLE LATENCY
COMPONENTS; TONE SEQUENCES; SCENE ANALYSIS; PERCEPTUAL ORGANIZATION;
FUNDAMENTAL-FREQUENCY; SONGBIRD FOREBRAIN; EVOKED-POTENTIALS; TIME
INTERVALS
AB Auditory streaming refers to the perceptual parsing of acoustic sequences into "streams", which makes it possible for a listener to follow the sounds from a given source amidst other sounds. Streaming is currently regarded as an important function of the auditory system in both humans and animals, crucial for survival in environments that typically contain multiple sound sources. This article reviews recent findings concerning the possible neural mechanisms behind this perceptual phenomenon at the level of the auditory cortex. The first part is devoted to intra-cortical recordings, which provide insight into the neural "micromechanisms" of auditory streaming in the primary auditory cortex (A1). In the second part, recent results obtained using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in humans, which suggest a contribution from cortical areas other than A1, are presented. Overall, the findings concur to demonstrate that many important features of sequential streaming can be explained relatively simply based on neural responses in the auditory cortex. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA.
MIT, Elect Res Lab, Cambridge, MA 02139 USA.
MRC, Cognit & Brain Sci Unit, Cambridge, England.
Univ Heidelberg, Dept Neurol, D-6900 Heidelberg, Germany.
Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Georgetown Inst Cognit & Computat Sci, Washington, DC 20007 USA.
Harvard Univ, MIT, Speech & Hearing Biosci & Technol Program, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
RP Micheyl, C (reprint author), Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA.
EM cmicheyl@umn.edu
RI Carlyon, Robert/A-5387-2010; Rauschecker, Josef/A-4120-2013
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NR 88
TC 93
Z9 94
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 116
EP 131
DI 10.1016/j.heares.2007.01.007
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100012
PM 17307315
ER
PT J
AU Davis, MH
Johnsrude, IS
AF Davis, Matthew H.
Johnsrude, Ingrid S.
TI Hearing speech sounds: Top-down influences on the interface between
audition and speech perception
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC Inst Hearing Res
DE speech perception; perceptual grouping; lexical segmentation; perceptual
learning; categorical perceptions; fMRI; auditory cortex; temporal lobe;
frontal lobe; feedback
ID SUPERIOR TEMPORAL SULCUS; PRECATEGORICAL ACOUSTIC STORAGE; PARABELT
AUDITORY-CORTEX; PRIMATE CEREBRAL-CORTEX; SHORT-TERM-MEMORY; LEXICAL
ACCESS; RHESUS-MONKEY; CORTICAL CONNECTIONS; PREFRONTAL CORTEX; LANGUAGE
COMPREHENSION
AB This paper focuses on the cognitive and neural mechanisms of speech perception: the rapid, and highly automatic processes by which complex time-varying speech signals are perceived as sequences of meaningful linguistic units. We will review four processes that contribute to the perception of speech: perceptual grouping, lexical segmentation, perceptual learning and categorical perception, in each case presenting perceptual evidence to support highly interactive processes with top-down information flow driving and constraining interpretations of spoken input. The cognitive and neural underpinnings of these interactive processes appear to depend on two distinct representations of heard speech: an auditory, echoic representation of incoming speech, and a motoric/somatotopic representation of speech as it would be produced. We review the neuroanatomical system supporting these two key properties of speech perception and discuss how this system incorporates interactive processes and two parallel echoic and somato-motoric representations, drawing on evidence from functional neuroimaging studies in humans and from comparative anatomical studies. We propose that top-down interactive mechanisms within auditory networks play an important role in explaining the perception of spoken language. (c) 2007 Elsevier B.V. All rights reserved.
C1 MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England.
Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
RP Davis, MH (reprint author), MRC, Cognit & Brain Sci Unit, 15 Chaucer Rd, Cambridge CB2 7EF, England.
EM matt.davis@mrc-cbu.cam.ac.uk
RI Davis, Matthew/F-6039-2010; Johnsrude, Ingrid/G-4694-2011
OI Johnsrude, Ingrid/0000-0002-7810-1333
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NR 176
TC 106
Z9 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 132
EP 147
DI 10.1016/j.heares.2007.01.014
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100013
PM 17317056
ER
PT J
AU Palmer, AR
Hall, DA
Sumner, C
Barrett, DJK
Jones, S
Nakamoto, K
Moore, DR
AF Palmer, A. R.
Hall, D. A.
Sumner, C.
Barrett, D. J. K.
Jones, S.
Nakamoto, K.
Moore, D. R.
TI Some investigations into non-passive listening
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE auditory cortex; attention; corticofugal
ID PRIMARY AUDITORY-CORTEX; MEDIAL GENICULATE-BODY; SINGLE-UNIT ACTIVITY;
GUINEA-PIG; CORTICOFUGAL MODULATION; SELECTIVE ATTENTION; BEHAVIORAL
DEPENDENCY; INFERIOR COLLICULUS; CORTICAL ACTIVATION; COCHLEAR NUCLEUS
AB Our knowledge of the function of the auditory nervous system is based upon a wealth of data obtained, for the most part, in anaesthetised animals. More recently, it has been generally acknowledged that factors such as attention profoundly modulate the activity of sensory systems and this can take place at many levels of processing. Imaging studies, in particular, have revealed the greater activation of auditory areas and areas outside of sensory processing areas when attending to a stimulus. We present here a brief review of the consequences of such non-passive listening and go on to describe some of the experiments we are conducting to investigate them. In imaging studies, using fMRI, we can demonstrate the activation of attention networks that are non-specific to the sensory modality as well as greater and different activation of the areas of the supra-temporal plane that includes primary and secondary auditory areas. The profuse descending connections of the auditory system seem likely to be part of the mechanisms subserving attention to sound. These are generally thought to be largely inactivated by anaesthesia. However, we have been able to demonstrate that even in an anaesthetised preparation, removing the descending control from the cortex leads to quite profound changes in the temporal patterns of activation by sounds in thalamus and inferior colliculus. Some of these effects seem to be specific to the ear of stimulation and affect interaural processing. To bridge these observations we are developing an awake behaving preparation involving freely moving animals in which it will be possible to investigate the effects of consciousness (by contrasting awake and anaesthetized), passive and active listening. (c) 2006 Elsevier B.V. All rights reserved.
C1 MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Palmer, AR (reprint author), MRC, Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England.
EM arp@ihr.mrc.ac.uk
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NR 61
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 148
EP 157
DI 10.1016/j.heares.2006.12.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100014
PM 17275232
ER
PT J
AU Irvine, DRF
AF Irvine, Dexter R. F.
TI Auditory cortical plasticity: Does it provide evidence for cognitive
processing in the auditory cortex?
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE cholinergic modulation; classical conditioning; cochlear lesion;
perceptual learning; receptive field; tonotopic organization
ID PRIMARY VISUAL-CORTEX; EXPERIENCE-DEPENDENT PLASTICITY; FREQUENCY
RECEPTIVE-FIELDS; INTRACOCHLEAR ELECTRICAL-STIMULATION; PRIMARY
SOMATOSENSORY CORTEX; INFERIOR COLLICULUS NEURONS; PARTIAL COCHLEAR
LESIONS; ADULT FLYING-FOX; CHOLINERGIC MODULATION; HEARING-LOSS
AB The past 20 years have seen substantial changes in our view of the nature of the processing carried out in auditory cortex. Some processing of a cognitive nature, previously attributed to higher-order "association" areas, is now considered to take place in auditory cortex itself. One argument adduced in support of this view is the evidence indicating a remarkable degree of plasticity in the auditory cortex of adult animals. Such plasticity has been demonstrated in a wide range of paradigms, in which auditory input or the behavioural significance of particular inputs is manipulated. Changes over the same time period in our conceptualization of the receptive fields of cortical neurons, and well-established mechanisms for use-related changes in synaptic function, can account for many forms of auditory cortical plasticity. On the basis of a review of auditory cortical plasticity and its probable mechanisms, it is argued that only plasticity associated with learning tasks provides a strong case for cognitive processing in auditory cortex. Even in this case the evidence is indirect, in that it has not yet been established that the changes in auditory cortex are necessary for behavioural learning and memory. Although other lines of evidence provide convincing support for cognitive processing in auditory cortex, that provided by auditory cortical plasticity remains equivocal. (c) 2007 Elsevier B.V. All rights reserved.
C1 Monash Univ, Fac Med Nursing & Hlth Sci, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia.
Bion Ear Inst, Melbourne, Vic 3002, Australia.
RP Irvine, DRF (reprint author), Monash Univ, Fac Med Nursing & Hlth Sci, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia.
EM d.irvine@med.monash.edu.au
RI Irvine, Dexter/F-7474-2011
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NR 113
TC 29
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 158
EP 170
DI 10.1016/j.heares.2007.01.006
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100015
PM 17303356
ER
PT J
AU Kilgard, MP
Vazquez, JL
Engineer, ND
Pandya, PK
AF Kilgard, M. P.
Vazquez, J. L.
Engineer, N. D.
Pandya, P. K.
TI Experience dependent plasticity alters cortical synchronization
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE synchrony; cross-correlation; sensory coding; acetylcholine; cholinergic
ID PRIMARY AUDITORY-CORTEX; CAT VISUAL-CORTEX; FOREBRAIN CHOLINERGIC
SYSTEM; RECEPTIVE-FIELD PROPERTIES; CROSS-CORRELATION ANALYSIS; INDUCED
HEARING-LOSS; ADULT OWL MONKEYS; NUCLEUS BASALIS; OSCILLATORY RESPONSES;
NEURAL ACTIVITY
AB Theories of temporal coding by cortical neurons are supported by observations that individual neurons can respond to sensory stimulation with millisecond precision and that activity in large populations is often highly correlated. Synchronization is highest between neurons with overlapping receptive fields and modulated by both sensory stimulation and behavioral state. It is not yet clear whether cortical synchronization is an epiphenomenon or a critical component of efficient information transmission. Experimental manipulations that generate receptive field plasticity can be used to test the relationship between synchronization and receptive fields. Here we demonstrate that increasing receptive field size in primary auditory cortex by repeatedly pairing a train of tones with nucleus basalis (NB) stimulation increases synchronization, and decreasing receptive field size by pairing different tone frequencies with NB stimulation decreases synchronization. These observations seem to support the conclusion that neural synchronization is simply an artifact caused by common inputs. However. pairing tone trains of different carrier frequencies with NB stimulation increases receptive field size without increasing synchronization. and environmental enrichment increases synchronization without increasing receptive field size. The observation that receptive fields and synchronization can be manipulated independently suggests that common inputs are only one of many factors sharing the strength and temporal precision of cortical synchronization and supports the hypothesis that precise neural synchronization contributes to sensory information processing. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Texas, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
Univ Illinois, Dept Speech & Hearing Sci, Champaign, IL 61820 USA.
RP Kilgard, MP (reprint author), Univ Texas, Sch Behav & Brain Sci, 2601 N Floyd Rd, Richardson, TX 75083 USA.
EM kilgard@utdallas.edu
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NR 77
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 171
EP 179
DI 10.1016/j.heares.2007.01.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100016
PM 17317055
ER
PT J
AU Hromadka, T
Zador, AM
AF Hromadka, Tomas
Zador, Anthony M.
TI Toward the mechanisms of auditory attention
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE auditory cortex; attention; rat; rodent
ID SPECTROTEMPORAL RECEPTIVE-FIELDS; VISUAL-ATTENTION; UNANESTHETIZED CATS;
EVOKED-POTENTIALS; CORTEX; PLASTICITY; MONKEYS; TASK; EVENTS
AB Since the earliest studies of auditory cortex, it has been clear that an animal's behavioral or attentional state can play a crucial role in shaping the response characteristics of single neurons. Much of what has been learned about attention has been made using human and animal models, but little is known about the cellular and synaptic mechanisms by which attentional modulation of neuronal responses occurs. The use of rodent experimental models allows us to exploit the full armamentarium of modern cellular and molecular neuroscience techniques. Here we present our program for studying auditory attention, specifically for development of rodent models of attention and finding the neural correlates of attention. (c) 2007 Elsevier B.V. All rights reserved.
C1 Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
RP Zador, AM (reprint author), Cold Spring Harbor Lab, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA.
EM zador@cshl.edu
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NR 26
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 180
EP 185
DI 10.1016/j.heares.2007.01.002
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100017
PM 17307316
ER
PT J
AU Fritz, JB
Elhilali, M
David, SV
Shamma, SA
AF Fritz, Jonathan B.
Elhilali, Mounya
David, Stephen V.
Shamma, Shihab A.
TI Does attention play a role in dynamic receptive field adaptation to
changing acoustic salience in Al?
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE auditory cortex; receptive field; STRF; plasticity; attention; acoustic
salience; ferret; Al
ID PRIMARY AUDITORY-CORTEX; PRIMARY VISUAL-CORTEX; TOP-DOWN INFLUENCES;
MACAQUE AREA V4; SELECTIVE ATTENTION; PHYSIOLOGICAL PLASTICITY; CORTICAL
PLASTICITY; TEMPORAL PLASTICITY; PREFRONTAL CORTEX; SPATIAL ATTENTION
AB Acoustic filter properties of A1 neurons can dynamically adapt to stimulus statistics, classical conditioning, instrumental learning and the changing auditory attentional focus. We have recently developed an experimental paradigm that allows us to view cortical receptive field plasticity on-line as the animal meets different behavioral challenges by attending to salient acoustic cues and changing its cortical filters to enhance performance. We propose that attention is the key trigger that initiates a cascade of events leading to the dynamic receptive field changes that we observe. In our paradigm, ferrets were initially trained, using conditioned avoidance training techniques, to discriminate between background noise stimuli (temporally orthogonal ripple combinations) and foreground tonal target stimuli. They learned to generalize the task for a wide variety of distinct background and foreground target stimuli. We recorded cortical activity in the awake behaving animal and computed on-line spectrotemporal receptive fields (STRFs) of single neurons in A1. We observed clear, predictable task-related changes in STRF shape while the animal performed spectral tasks (including single tone and multi-tone detection, and two-tone discrimination) with different tonal targets. A different set of task-related changes occurred when the animal performed temporal tasks (including gap detection and click-rate discrimination). Distinctive cortical STRF changes may constitute a "task-specific signature". These spectral and temporal changes in cortical filters occur quite rapidly, within 2 min of task onset, and fade just as quickly after task completion, or in some cases, persisted for hours. The same cell could multiplex by differentially changing its receptive field in different task conditions. On-line dynamic task-related changes, as well as persistent plastic changes, were observed at a single-unit, multi-unit and population level. Auditory attention is likely to be pivotal in mediating these task-related changes since the magnitude of STRF changes correlated with behavioral performance on tasks with novel targets. Overall, these results suggest the presence of an attention-triggered plasticity algorithm in A1 that can swiftly change STRF shape by transforming receptive fields to enhance figure/ground separation, by using a contrast matched filter to filter out the background, while simultaneously enhancing the salient acoustic target in the foreground. These results favor the view of a nimble, dynamic, attentive and adaptive brain that can quickly reshape its sensory filter properties and sensori-motor links on a moment-to-moment basis, depending upon the current challenges the animal faces. In this review, we summarize our results in the context of a broader survey of the field of auditory attention, and then consider neuronal networks that could give rise to this phenomenon of attention-driven receptive field plasticity in A1. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Maryland, Ctr Auditory & Acoust Res, College Pk, MD 20742 USA.
RP Fritz, JB (reprint author), Univ Maryland, Ctr Auditory & Acoust Res, College Pk, MD 20742 USA.
EM ripple@isr.umd.edu
RI Elhilali, Mounya/A-3396-2010; Shamma, Shihab/F-9852-2012
OI Elhilali, Mounya/0000-0003-2597-738X;
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NR 170
TC 75
Z9 76
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 186
EP 203
DI 10.1016/j.heares.2007.01.009
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100018
PM 17329048
ER
PT J
AU Russ, BE
Lee, YS
Cohen, YE
AF Russ, Brian E.
Lee, Yune-Sang
Cohen, Yale E.
TI Neural and behavioral correlates of auditory categorization
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE categorization; rhesus macaques; audition; prefrontal cortex
ID PRIMATE PREFRONTAL CORTEX; INFERIOR TEMPORAL CORTEX; FIELD PLAYBACK
EXPERIMENTS; VOICE ONSET TIME; SPEECH-PERCEPTION; RHESUS-MONKEYS;
ENHANCED DISCRIMINABILITY; CATEGORICAL PERCEPTION; SEMANTIC
COMMUNICATION; VISUAL CATEGORIZATION
AB Goal-directed behavior is the essence of adaptation because it allows humans and other animals to respond dynamically to different environmental scenarios. Goal-directed behavior can be characterized as the formation of dynamic links between stimuli and actions. One important attribute of goal-directed behavior is that linkages can be formed based on how a stimulus is categorized. That is, links are formed based on the membership of a stimulus in a particular functional category. In this review, we review categorization with an emphasis on auditory categorization. We focus on the role of categorization in language and non-human vocalizations. We present behavioral data indicating that non-human primates categorize and respond to vocalizations based on differences in their putative meaning and not differences in their acoustics. Finally, we present evidence suggesting that the ventrolateral prefrontal cortex plays an important role in processing auditory objects and has a specific role in the representation of auditory categories. (c) 2006 Elsevier B.V. All rights reserved.
C1 Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA.
Dartmouth Coll, Ctr Cognit Neurosci, Hanover, NH 03755 USA.
RP Cohen, YE (reprint author), Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA.
EM yec@dartmouth.edu
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NR 131
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 204
EP 212
DI 10.1016/j.heares.2006.10.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100019
PM 17208397
ER
PT J
AU Scheich, H
Brechmann, A
Brosch, M
Budinger, E
Ohl, FW
AF Scheich, Henning
Brechmann, Andre
Brosch, Michael
Budinger, Eike
Ohl, Frank W.
TI The cognitive auditory cortex: Task-specificity of stimulus
representations
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC Inst Hearing Res
DE anatomy; behaviour; categorization; discrimination; functional magnetic
resonance imaging
ID GERBIL MERIONES-UNGUICULATUS; FREQUENCY-MODULATED TONES; SHORT-TERM
MEMORY; MONGOLIAN GERBIL; WORKING-MEMORY; FUNCTIONAL-ORGANIZATION;
VISUAL-CORTEX; SENSORY SYSTEMS; CONNECTIONS; NEOCORTEX
AB Auditory cortex (AC), like subcortical auditory nuclei, represents properties of auditory stimuli by spatiotemporal activation patterns across neurons. A tacit assumption of AC research has been that the multiplicity of functional maps in primary and secondary areas serves a refined continuation of subcortical stimulus processing, i.e. a parallel orderly analysis of distinct properties of a complex sound. This view. which was mainly derived from exposure to parametric sound variation, may not fully capture the essence of cortical processing. Neocortex, in spite of its parcellation into diverse sensory, motor, associative, and cognitive areas, exhibits a rather stereotyped local architecture. The columnar arrangement of the neocortex and the quantitatively dominant connectivity with numerous other cortical areas are two of its key Features. This suggests that cortex has a rather common function which lies beyond those usually leading to the distinction of functional areas. We propose that task-relatedness of the way, how any information can be represented in cortex, is one general consequence of the architecture and corticocortical connectivity. Specifically, this hypothesis predicts different spatiotemporal representations of auditory stimuli when concepts and strategies how these stimuli are analysed do change. We will describe, in an exemplary fashion, cortical patterns of local field potentials in gerbil, of unit spiking activity in monkey, and of fMRI signals in human AC during the execution of different tasks mainly in the realm of category formation of sounds. We demonstrate that the representations reflect context- and memory-related. conceptual and executional aspects of a task and that they can predict the behavioural outcome. (c) 2007 Elsevier B.V. All rights reserved.
C1 Leibniz Inst Neurobiol, Dept Auditory Learning & Speech, D-39118 Magdeburg, Germany.
Leibniz Inst Neurobiol, Special Lab Noninvas Brain Imaging, D-39118 Magdeburg, Germany.
Univ Magdeburg, Neurol Clin 2, D-39120 Magdeburg, Germany.
Univ Magdeburg, Inst Biol, D-39106 Magdeburg, Germany.
Leibniz Inst Neurobiol, Res Grp Neuroprosthet, D-39118 Magdeburg, Germany.
RP Budinger, E (reprint author), Leibniz Inst Neurobiol, Dept Auditory Learning & Speech, Brenneckestr 6, D-39118 Magdeburg, Germany.
EM scheich@ifn-magdeburg.de; brechmann@ifn-magdeburg.de;
brosch@ifn-magdeburg.de; budinger@ifn-magdeburg.de;
frank.ohl@ifn-magdeburg.de
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NR 72
TC 48
Z9 48
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 213
EP 224
DI 10.1016/j.heares.2007.01.025
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100020
PM 17368987
ER
PT J
AU Alain, C
AF Alain, Claude
TI Breaking the wave: Effects of attention and learning on concurrent sound
perception
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Auditory Cortex - Listening Brain
CY SEP, 2006
CL Nottingham, ENGLAND
SP MIC inst Hearing Res
DE streaming; speech; ERP; attention; auditory; perception
ID AUDITORY SCENE ANALYSIS; STARLINGS STURNUS-VULGARIS; RECEPTIVE-FIELD
PLASTICITY; AGE-RELATED-CHANGES; ADULT OWL MONKEYS; VOWEL SEGREGATION;
COMPLEX TONES; FUNDAMENTAL FREQUENCIES; HARMONIC COMPLEXES; STREAM
SEGREGATION
AB The auditory surrounding is often complex with many sound sources active simultaneously. Yet listeners are proficient in breaking apart the composite acoustic wave reaching the ears. This achievement is thought to be the result of bottom-up as well as top-down processes that reflect listeners' experience and knowledge of the auditory environment. Here, specific findings concerning the role of bottom-up and top-down (schema-driven) processes on concurrent sound perception are reviewed, with particular emphasis on studies that have used scalp recording of event-related brain potentials. Findings from several studies indicate that frequency periodicity, upon which Concurrent sound perception partly depends, is quickly and automatically registered in primary auditory cortex. Moreover, success in identifying concurrent vowels is accompanied by enhanced neural activity, as revealed by functional magnetic resonance imaging, in thalamus, primary auditory cortex and planum temporale. Lastly, listeners' ability to segregate concurrent vowels improves with training and these neuroplastic changes occur rapidly, demonstrating the flexibility of human speech segregation mechanisms. Together. these studies suggest that the primary auditory cortex and the planum temporale play an important role in concurrent sound perception, and reveal a link between thalamo-cortical activation and the successful separation and identification of speech sounds presented simultaneously. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Toronto, Dept Psychol, Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6A 2E1, Canada.
RP Alain, C (reprint author), Univ Toronto, Dept Psychol, Baycrest Ctr Geriatr Care, Rotman Res Inst, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada.
EM calain@rotman-baycrest.on.ca
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NR 66
TC 50
Z9 50
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2007
VL 229
IS 1-2
BP 225
EP +
DI 10.1016/j.heares.2007.01.011
PG 48
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 191PI
UT WOS:000248143100021
PM 17303355
ER
EF