FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Clipperton-Allen, AE
Page, DT
AF Clipperton-Allen, Amy E.
Page, Damon T.
TI Pten haploinsufficient mice show broad brain overgrowth but selective
impairments in autism-relevant behavioral tests
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID TUMOR-SUPPRESSOR GENE; SPECTRUM DISORDERS; SYNAPTIC PLASTICITY; HEAD
CIRCUMFERENCE; TENSIN HOMOLOG; KNOCKOUT MICE; MOUSE MODEL;
NEURODEVELOPMENTAL DISORDERS; SOCIAL INFORMATION; DOPAMINE NEURONS
AB Accelerated head and brain growth (macrocephaly) during development is a replicated biological finding in a subset of individuals with autism spectrum disorder (ASD). However, the relationship between brain overgrowth and the behavioral and cognitive symptoms of ASD is poorly understood. The PI3K-Akt-mTOR pathway regulates cellular growth; several genes encoding negative regulators of this pathway are ASD risk factors, including PTEN. Mutations in PTEN have been reported in individuals with ASD and macrocephaly. We report that brain overgrowth is widespread in Pten germline haploinsufficient (Pten(+/-)) mice, reflecting Pten mRNA expression in the developing brain. We then ask if broad brain overgrowth translates into general or specific effects on the development of behavior and cognition by testing Pten(+/-) mice using assays relevant to ASD and comorbidities. Deficits in social behavior were observed in both sexes. Males also showed abnormalities related to repetitive behavior and mood/anxiety. Females exhibited circadian activity and emotional learning phenotypes. Widespread brain overgrowth together with selective behavioral impairments in Pten(+/-) mice raises the possibility that most brain areas and constituent cell types adapt to an altered trajectory of growth with minimal impact on the behaviors tested in our battery; however, select areas/cell types relevant to social behavior are more vulnerable or less adaptable, thus resulting in social deficits. Probing dopaminergic neurons as a candidate vulnerable cell type, we found social behavioral impairments in mice with Pten conditionally inactivated in dopaminergic neurons that are consistent with the possibility that desynchronized growth in key cell types may contribute to ASD endophenotypes.
C1 [Clipperton-Allen, Amy E.; Page, Damon T.] Scripps Res Inst, Dept Neurosci, Jupiter, FL 33458 USA.
RP Page, DT (reprint author), Scripps Res Inst, Dept Neurosci, 130 Scripps Way, Jupiter, FL 33458 USA.
EM paged@scripps.edu
FU Scripps Research Institute
FX We are grateful for gift funds from Mrs Nancy Lurie Marks and startup
funds from The Scripps Research Institute for support.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
American Psychiatric Association, 2005, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Backman CM, 2006, GENESIS, V44, P383, DOI 10.1002/dvg.20228
Baskerville TA, 2010, CNS NEUROSCI THER, V16, pe92, DOI 10.1111/j.1755-5949.2010.00154.x
Benvenuto A, 2013, BRAIN DEV-JPN, V35, P119, DOI 10.1016/j.braindev.2012.03.015
Boccone L, 2006, AM J MED GENET A, V140A, P1965, DOI 10.1002/ajmg.a.31396
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Bryant DN, 2006, ENDOCRINE, V29, P199, DOI 10.1385/ENDO:29:2:199
Busch RM, 2013, GENET MED, V15, P548, DOI 10.1038/gim.2013.1
Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493
Choleris E, 2007, P NATL ACAD SCI USA, V104, P4670, DOI 10.1073/pnas.0700670104
Choleris E, 2011, NEUROPSYCHOPHARMACOL, V36, P1689, DOI 10.1038/npp.2011.50
Choleris E, 2003, P NATL ACAD SCI USA, V100, P6192, DOI 10.1073/pnas.0631699100
Conti S, 2012, J CHILD NEUROL, V27, P392, DOI 10.1177/0883073811420296
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
Crawley JN, 2007, NEUROPEPTIDES, V41, P145, DOI 10.1016/j.npep.2007.02.002
de la Mora MP, 2010, PROG NEUROBIOL, V90, P198, DOI 10.1016/j.pneurobio.2009.10.010
Deruelle C, 2008, AUTISM RES, V1, P91, DOI 10.1002/aur.13
de Vries PJ, 2010, NEUROTHERAPEUTICS, V7, P275, DOI 10.1016/j.nurt.2010.05.001
Diaz-Ruiz O, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007027
Di Matteo V, 2001, TRENDS PHARMACOL SCI, V22, P229, DOI 10.1016/S0165-6147(00)01688-6
Donaldson ZR, 2008, SCIENCE, V322, P900, DOI 10.1126/science.1158668
Dunlop BW, 2007, ARCH GEN PSYCHIAT, V64, P327, DOI 10.1001/archpsyc.64.3.327
Enter D, 2012, GENES BRAIN BEHAV, V11, P671, DOI 10.1111/j.1601-183X.2012.00791.x
Ernst M, 1997, LANCET, V350, P638, DOI 10.1016/S0140-6736(05)63326-0
Farmer C, 2013, DRUGS, V73, P303, DOI 10.1007/s40265-013-0021-7
Fox MA, 2013, PSYCHOPHARMACOLOGY, V227, P685, DOI 10.1007/s00213-013-2988-x
Fraser MM, 2008, NEUROSCIENCE, V151, P476, DOI 10.1016/j.neuroscience.2007.10.048
Gaigg SB, 2008, NEUROPSYCHOLOGIA, V46, P2336, DOI 10.1016/j.neuropsychologia.2008.03.008
Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012
Gimm O, 2000, HUM MOL GENET, V9, P1633, DOI 10.1093/hmg/9.11.1633
Goffin A, 2001, AM J MED GENET, V105, P521, DOI 10.1002/ajmg.1477
Groszer M, 2001, SCIENCE, V294, P2186, DOI 10.1126/science.1065518
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
Herman GE, 2007, AM J MED GENET A, V143A, P589, DOI 10.1002/ajmg.a.31619
Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
Insel TR, 2004, ANNU REV NEUROSCI, V27, P697, DOI 10.1146/annurev.neuro.27.070203.144148
Jay TM, 2003, PROG NEUROBIOL, V69, P375, DOI 10.1016/S0301-0082(03)00085-6
Ji SP, 2006, NAT MED, V12, P324, DOI 10.1038/nm1349
Jiang H, 2005, CELL, V120, P123, DOI 10.1016/j.cell.2004.12.033
Jurado S, 2010, EMBO J, V29, P2827, DOI 10.1038/emboj.2010.160
Kaidanovich-Beilin O, 2011, J VIS EXP, V48, P2473
Kalueff AV, 2010, NEUROSCI BIOBEHAV R, V34, P373, DOI 10.1016/j.neubiorev.2009.08.003
Kotagal S, 2012, PEDIATR NEUROL, V47, P242, DOI 10.1016/j.pediatrneurol.2012.05.007
Krishnan V, 2008, BIOL PSYCHIAT, V64, P691, DOI 10.1016/j.biopsych.2008.06.003
Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
Kwon CH, 2001, NAT GENET, V29, P404, DOI 10.1038/ng781
Lachyankar MB, 2000, J NEUROSCI, V20, P1404
Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
Lee TL, 2012, GENE, V496, P88, DOI 10.1016/j.gene.2012.01.020
Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453
Lesche R, 2002, GENESIS, V32, P148, DOI 10.1002/gene.10036
Lian ZL, 2006, J CELL PHYSIOL, V208, P255, DOI 10.1002/jcp.20681
Luukko K, 1999, MECH DEVELOP, V83, P187, DOI 10.1016/S0925-4773(99)00050-7
Malow B., 2008, SLEEP MED CLIN, V3, P479, DOI 10.1016/j.jsmc.2008.04.004
Maras KL, 2012, EMOTION, V12, P1118, DOI 10.1037/a0026679
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
McBride KL, 2010, AUTISM RES, V3, P137, DOI 10.1002/aur.132
Miano S, 2007, SLEEP MED, V9, P64, DOI 10.1016/j.sleep.2007.01.014
Miles JH, 2000, AM J MED GENET, V95, P339, DOI 10.1002/1096-8628(20001211)95:4<339::AID-AJMG9>3.0.CO;2-B
Mozhui K, 2010, J NEUROSCI, V30, P5357, DOI 10.1523/JNEUROSCI.5017-09.2010
Mulholland DJ, 2006, ONCOGENE, V25, P329, DOI 10.1038/sj.onc.1209020
Musatov S, 2004, P NATL ACAD SCI USA, V101, P3627, DOI 10.1073/pnas.0308289101
Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
Neuhaus E., 2010, CLIN PSYCHOL REV, V30, P773
Neumann ID, 2012, TRENDS NEUROSCI, V35, P649, DOI 10.1016/j.tins.2012.08.004
Ning K, 2004, J NEUROSCI, V24, P4052, DOI 10.1523/JNEUROSCI.5449-03.2004
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Orrico A, 2009, CLIN GENET, V75, P195, DOI 10.1111/j.1399-0004.2008.01074.x
Page DT, 2009, P NATL ACAD SCI USA, V106, P1989, DOI 10.1073/pnas.0804428106
Page DT, 2011, ANAT REC, V294, P1671, DOI 10.1002/ar.21473
Perandones C, 2004, MOL BRAIN RES, V128, P8, DOI 10.1016/j.molbrainres.2004.05.021
Perou Ruth, 2013, MMWR Surveill Summ, V62 Suppl 2, P1
Pinal N, 2006, CURR BIOL, V16, P140, DOI 10.1016/j.cub.2005.11.068
PIVEN J, 1995, AM J PSYCHIAT, V152, P1145
Podsypanina K, 1999, P NATL ACAD SCI USA, V96, P1563, DOI 10.1073/pnas.96.4.1563
Raznahan A, 2013, BIOL PSYCHIAT, V74, P563, DOI 10.1016/j.biopsych.2013.03.022
Skokauskas N, 2010, PSYCHOPATHOLOGY, V43, P8, DOI 10.1159/000255958
South M, 2011, AUTISM RES, V4, P412, DOI 10.1002/aur.221
South M, 2008, J INT NEUROPSYCH SOC, V14, P42, DOI 10.1017/S1355617708080107
Sparks BF, 2002, NEUROLOGY, V59, P184
Sperow M, 2012, J PHYSIOL-LONDON, V590, P777, DOI 10.1113/jphysiol.2011.220236
Staal WG, 2012, J AUTISM DEV DISORD, V42, P885, DOI 10.1007/s10803-011-1312-z
Stein MT, 2010, J DEV BEHAV PEDIATR, V31, P632, DOI 10.1097/DBP.0b013e3181ef422a
Sulis ML, 2003, TRENDS CELL BIOL, V13, P478, DOI 10.1016/S0962-8924(03)00175-2
Takayanagi Y, 2010, BIOCHEM BIOPH RES CO, V396, P703, DOI 10.1016/j.bbrc.2010.04.165
Takeuchi K, 2013, P NATL ACAD SCI USA, V110, P4738, DOI 10.1073/pnas.1222803110
Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
Van Diepen MT, 2008, DEV NEUROSCI-BASEL, V30, P59, DOI 10.1159/000109852
Varea O, 2013, BBA-MOL CELL RES, V1833, P1052, DOI 10.1016/j.bbamcr.2012.12.019
Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762
Vriend JL, 2011, J PEDIATR PSYCHOL, V36, P1017, DOI 10.1093/jpepsy/jsr044
Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709
World Health Organisation, 1992, ICD 10 CLASS MENT BE
Xin L, 2006, P NATL ACAD SCI USA, V103, P7789, DOI 10.1073/pnas.0602567103
Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
Zhou J, 2012, CURR OPIN NEUROBIOL, V22, P873, DOI 10.1016/j.conb.2012.05.004
Zweifel LS, 2011, NAT NEUROSCI, V14, P620, DOI 10.1038/nn.2808
NR 102
TC 5
Z9 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD JUL
PY 2014
VL 23
IS 13
BP 3490
EP 3505
DI 10.1093/hmg/ddu057
PG 16
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AK0ST
UT WOS:000338126300012
PM 24497577
ER
PT J
AU Sinzig, J
Vinzelberg, I
Evers, D
Lehmkuhl, G
AF Sinzig, Judith
Vinzelberg, Isabella
Evers, Dagmar
Lehmkuhl, Gerd
TI Executive function and attention profiles in preschool and elementary
school children with autism spectrum disorders or ADHD
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE ADHD; attention; autism; executive functions; neuropsychology; preschool
age
ID DEFICIT-HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL DISORDER;
DEFICIT/HYPERACTIVITY DISORDER; SUSTAINED ATTENTION;
PSYCHIATRIC-DISORDERS; COMORBIDITY; PERFORMANCE; SYMPTOMS;
METHYLPHENIDATE; BEHAVIOR
AB Both autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) show executive function and attention problems. By now, these are well described in school children and adolescents, but not in preschool or elementary school children. The goal of this study was to compare the neuropsychological profiles of executive and attention functions in an ADHD, an ASD, and a typically-developing group. Eighty-five children aged 4-9 years old with ADHD (n=30) or ASD (n=26) and healthy children (n=29) were included consecutively. Psychopathology was evaluated using the KIDDIE-SADS, the Child Behaviour Checklist (CBCL), and symptom checklists for ADHD according to DSM-IV. Assessment of neuropsychological functioning included tasks from the Amsterdam Neuropsychological Tasks (ANT), namely, inhibition (GoNoGo), flexibility (shifting attentional set visual), and sustained attention (sustained attention objects). A MANOVA with age and IQ as covariates revealed statistically significant group effects for the variable 'flexibility errors compatible'. Effect sizes showed clear deficits of children with ASD and ADHD in inhibition and, furthermore, impairments in sustained attention in ASD children. Pearson correlations revealed associations between social problems and aggressive behaviour with all three tasks in the ADHD group and between thought problems and sustained attention in the ASD group. Our hypothesis was partly confirmed as ADHD children showed more deficits in inhibition tasks than healthy children. However, there was no evidence that children with ASD have a specific profile in comparison to ADHD children.
C1 [Sinzig, Judith; Evers, Dagmar; Lehmkuhl, Gerd] Univ Cologne, Dept Child & Adolescent Psychiat, Cologne, Germany.
[Sinzig, Judith; Vinzelberg, Isabella] LVR Klin Bonn, Dept Child & Adolescent Psychiat, D-53111 Bonn, Germany.
[Evers, Dagmar] LVR Klin Viersen, Dept Child & Adolescent Psychiat, Viersen, Germany.
RP Sinzig, J (reprint author), LVR Klin Bonn, Dept Child & Adolescent Psychiat, Kaiser Karl Ring 10, D-53111 Bonn, Germany.
EM judith.sinzig@lvr.de
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Antshel KM, 2013, EXPERT REV NEUROTHER, V13, P1117, DOI 10.1586/14737175.2013.840417
Boelte S, 2006, DIAGNOSTISCHES INTER
Breckenridge K, 2013, BRIT J DEV PSYCHOL, V31, P271, DOI 10.1111/bjdp.12004
Buhler E, 2011, J AUTISM DEV DISORD, V41, P1718, DOI 10.1007/s10803-011-1205-1
Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50
Di Trani M, 2011, BRAIN DEV-JPN, V33, P462, DOI 10.1016/j.braindev.2010.06.002
Doepfner M., 2002, DIAGNOSTIC CHECKLIST
Doepfner M., 2002, DIAGNOSTIK SYSTEM PS
DuPaul GJ, 1998, J APPL BEHAV ANAL, V31, P579, DOI 10.1901/jaba.1998.31-579
Elsabbagh M, 2013, BIOL PSYCHIAT, V74, P189, DOI 10.1016/j.biopsych.2012.11.030
FARAONE SV, 1995, J ABNORM PSYCHOL, V104, P334, DOI 10.1037//0021-843X.104.2.334
GARRETSON HB, 1990, J AUTISM DEV DISORD, V20, P101, DOI 10.1007/BF02206860
Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P1437, DOI 10.1111/j.1469-7610.2004.00326.x
Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
Hanisch C, 2004, J NEURAL TRANSM, V111, P865, DOI 10.1007/s00702-003-0056-0
Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
Herpertz SC, 2001, BIOL PSYCHIAT, V50, P292, DOI 10.1016/S0006-3223(01)01075-7
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Howell G. S., 2000, DISS ABSTR INT, V62, P4788
Jensen VK, 1997, CLIN PEDIATR, V36, P555, DOI 10.1177/000992289703601001
Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019
Kaufman J, 2000, J AM ACAD CHILD PSY, V39, P1208, DOI 10.1097/00004583-200010000-00002
Kochhar P, 2011, CHILD CARE HLTH DEV, V37, P103, DOI 10.1111/j.1365-2214.2010.01123.x
Konrad K, 2004, J AM ACAD CHILD PSY, V43, P191, DOI 10.1097/01.chi.000010372.03068.15
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Mahone EM, 2012, NEUROPSYCHOL REV, V22, P361, DOI 10.1007/s11065-012-9217-y
Melchers P., 2009, KAUFMAN ASSESSMENT B
Nigg JT, 2005, BIOL PSYCHIAT, V57, P1424, DOI 10.1016/j.biopsych.2004.11.011
Nijmeijer JS, 2008, CLIN PSYCHOL REV, V28, P692, DOI 10.1016/j.cpr.2007.10.003
Nyden A., 1999, AUTISM, V3, P213, DOI 10.1177/1362361399003003002
Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
Pauli-Pott U, 2011, CLIN PSYCHOL REV, V31, P626, DOI 10.1016/j.cpr.2011.02.005
Pellicano E, 2013, AUTISM RES, V6, P258, DOI 10.1002/aur.1286
Ruehl D., 2004, DIAGNOSTISCHE BEOBAC
Serra M, 2003, J AUTISM DEV DISORD, V33, P303, DOI 10.1023/A:1024458618172
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Sinzig J, 2008, ACTA NEUROPSYCHIATR, V20, P207, DOI 10.1111/j.1601-5215.2008.00292.x
Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4
Skogan AH, 2014, CHILD NEUROPSYCHOL, V20, P607, DOI 10.1080/09297049.2013.838213
Slaats-Willemse D, 2003, J AM ACAD CHILD PSY, V42, P1242, DOI 10.1097/01.chi.0000081825.25107.f2
Smithson PE, 2013, J AUTISM DEV DISORD, V43, P1967, DOI 10.1007/s10803-012-1747-x
Stins JF, 2005, CHILD NEUROPSYCHOL, V11, P285, DOI 10.1080/09297040490916938
Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
Tye C., 2013, PSYCHOL MED, V15, P1
von Doepfner M., 1998, EINF ANL HAND DTSCH
Willcutt EG, 2005, BIOL PSYCHIAT, V57, P1336, DOI 10.1016/j.biopsych.2005.02.006
Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1
NR 50
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 2047-3869
EI 2047-3877
J9 INT J DEV DISABIL
JI Int. J. Dev. Disabil.
PD JUL
PY 2014
VL 60
IS 3
BP 144
EP 154
DI 10.1179/2047387714Y.0000000040
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK4YG
UT WOS:000338429900004
ER
PT J
AU Geurts, H
Sinzig, J
Booth, R
Happe, F
AF Geurts, Hilde
Sinzig, Judith
Booth, Rhonda
Happe, Francesca
TI Neuropsychological heterogeneity in executive functioning in autism
spectrum disorders
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; heterogeneity; executive functions; ADHD
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL
DISORDERS; DEFICIT HYPERACTIVITY DISORDER; ASPERGER-SYNDROME; CENTRAL
COHERENCE; CHILDREN; ADHD; PSYCHOPATHOLOGY; INDIVIDUALS; IMPAIRMENTS
AB In most research it is common to report results on a group level. For example, various studies report that children and adults with autism show executive function deficits. However, studies often differ in the pattern of findings. We believe this might be partly due to the heterogeneity of the autism population. Put differently, some people with autism might indeed have executive dysfunctions, but this does not mean that everybody with autism has such a deficit. In the current study we re-analysed published data from children with autism, children with Attention Deficit/Hyperactivity Disorder (also associated with executive dysfunction) and children without a clinical diagnosis. A surprisingly small number of children did indeed have executive function deficits. However, children with a clinical diagnosis had executive function deficits more often than those without a diagnosis. These findings show us that besides reporting findings on a group level, researchers need to report findings on an individual level. Understanding the differences between individuals with autism might help us in pinpointing differences in etiology, prognosis, and treatment response.
Different subsets of autism symptoms might be genetically partly independent. With respect to cognition, this may imply that one cognitive theory is unlikely to explain all symptoms and that there will be large individual differences in cognitive deficits/assets between individuals with autism. However, most journal articles report only group differences, treating individual differences more or less as 'noise' in the data. In the current study, we reanalyzed data from three independent studies (totaling 93 children with autism spectrum disorders (ASDs), 104 children with attention deficit hyperactivity disorder (ADHD), and 93 typically developing children) to examine the degree of heterogeneity in executive function deficits. The three main findings were that (1) only a small percentage of children with ASD had a significant deficit in measured executive function; (2) there is not just heterogeneity within ASD groups, but also across studies, and (3) in line with Nigg and colleagues (2005), only a small number of children with ADHD showed a significant inhibitory control deficit. Executive (dys)function cannot be a marker for ASD as defined in the DSM, but might have potential as a specifier like IQ and language. This is in line with the idea that the executive function account cannot be a sole explanation for ASD. The findings do suggest that an individual differences approach might give us more information on potential subtypes within the autism spectrum. Future research is needed to define and test neuropsychological subtypes and their external correlates, including etiology, prognosis, and treatment response.
C1 [Geurts, Hilde] Univ Amsterdam, Dept Psychol, Dutch Autism & ADHD Res Ctr dArc, Amsterdam, Netherlands.
[Geurts, Hilde] Dr Leo Kannerhuis, Autism Clin, Amsterdam, Netherlands.
[Sinzig, Judith] LVR Klin, Dept Child & Adolescent Psychiat, Bonn, Germany.
[Booth, Rhonda] UCL, Inst Child Hlth, London WC1E 6BT, England.
[Happe, Francesca] Kings Coll London, Inst Psychiat, Med Res Council Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
RP Geurts, H (reprint author), Univ Amsterdam, Dept Psychol, Dutch Autism & ADHD Res Ctr dArc, Amsterdam, Netherlands.
EM H.M.Geurts@uva.nl
CR Adamo N., 2013, EUROPEAN CHILD ADOLE, P1
Ambery FZ, 2006, AUTISM, V10, P551, DOI 10.1177/1362361306068507
American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Andersen PN, 2014, AUTISM, DOI [10.1177/1362361314524844, DOI 10.1177/1362361314524844]
Antshel KM, 2013, EXPERT REV NEUROTHER, V13, P1117, DOI 10.1586/14737175.2013.840417
(APA) APA, 2000, DIAGN STAT MAN MENT
Barendse EM, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-14
Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
Berger HJC, 2003, J CLIN EXP NEUROPSYC, V25, P502, DOI 10.1076/jcen.25.4.502.13870
Brunsdon VEA, 2014, AUTISM, V18, P17, DOI 10.1177/1362361313499456
Cambridge C, 2002, CANTABI
Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256
Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
Durston S, 2009, NEUROSCI BIOBEHAV R, V33, P674, DOI 10.1016/j.neubiorev.2008.08.009
Friedman NP, 2006, PSYCHOL SCI, V17, P172, DOI 10.1111/j.1467-9280.2006.01681.x
Geurts H. M., 2011, J AUTISM DEV DISORD
Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
Hannay H. J., 2004, NEUROPSYCHOLOGICAL A
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
Huizenga HM, 2007, NEUROPSYCHOLOGIA, V45, P2534, DOI 10.1016/j.neuropsychologia.2007.03.011
Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lin Y., 2013, PSYCHOL MED, P1
Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
Nigg JT, 2005, BIOL PSYCHIAT, V57, P1224, DOI 10.1016/j.biopsych.2004.08.025
Ogilvie JM, 2011, CRIMINOLOGY, V49, P1063, DOI 10.1111/j.1745-9125.2011.00252.x
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Russell J., 1997, AUTISM EXECUTIVE DIS
Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
Sergeant JA, 2002, BEHAV BRAIN RES, V130, P3, DOI 10.1016/S0166-4328(01)00430-2
Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4
Sonuga-Barke EJS, 2010, J AM ACAD CHILD PSY, V49, P345, DOI 10.1016/j.jaac.2009.12.018
Sturm H, 2004, DEV MED CHILD NEUROL, V46, P444, DOI 10.1017/S0012162204000738
Swanson J., 2012, RES AUTISM SPECT DIS, V7, P235
Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
Tye C., 2013, PSYCHOL MED, V15, P1
van der Meer JMJ, 2012, J AM ACAD CHILD PSY, V51, P1160, DOI 10.1016/j.jaac.2012.08.024
Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5
Viding E, 2007, BEHAV GENET, V37, P51, DOI 10.1007/s10519-006-9105-4
Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x
White SJ, 2011, J AUTISM DEV DISORD, V41, P1565, DOI 10.1007/s10803-011-1182-4
World Health Organization, 2008, ICD 10 INT STAT CLAS
NR 55
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 2047-3869
EI 2047-3877
J9 INT J DEV DISABIL
JI Int. J. Dev. Disabil.
PD JUL
PY 2014
VL 60
IS 3
BP 155
EP 162
DI 10.1179/2047387714Y.0000000047
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK4YG
UT WOS:000338429900005
ER
PT J
AU Willfors, C
Poltrago, L
Berggren, S
Coco, C
Anckarsater, H
Lichtenstein, P
Ronald, A
Bolte, S
AF Willfors, Charlotte
Poltrago, Lina
Berggren, Steve
Coco, Christina
Anckarsater, Henrik
Lichtenstein, Paul
Ronald, Angelica
Bolte, Sven
TI On the role of non-shared environment for executive functioning in ADHD:
a twin-differences design study
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Neurodevelopmental disorders; NDD; attention deficit hyperactivity
disorder; neuropsychology; neuropsychiatry; discordant twin pair design;
autism spectrum disorders; impulsivity; inhibition; concordance;
discordance; monozygotic twin pairs
ID DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; CARD SORTING TEST; EARLY ADOLESCENCE; BIRTH-WEIGHT; CHILDREN;
INHIBITION; CHILDHOOD; METAANALYSIS; SPECIFICITY
AB Introduction: The study of differences between monozygotic (MZ) twin pairs with respect to ADHD may provide novel leads to disentangle the environmental contribution driving its phenotypes.
Objectives: To examine non-shared environmental influences on executive function in dimensionally defined ADHD.
Methods: This study included 27 MZ twin pairs (7 female) aged 11-20 years being moderately to substantially discordant for ADHD traits as assessed by the Attention Problem (AP) scale of the Child Behavior Checklist/Adult Behavior Checklist. The twins completed the Wisconsin Card Sorting Test (WCST) for cognitive flexibility and the Tower Test (TT) for foresighted planning. Two statistical approaches were used to analyze the data. First, correlations between ADHD trait intra-pair differences and WCST and TT scores were calculated. Second, the significance of those intra-pair differences on WCST and TT, using ADHD as categorical variable in clinically discordant pairs, was tested.
Results: Both analysing strategies revealed a link between ADHD on one hand, and foresighted planning and inhibitory control on the other hand mediated by non-shared environmental factors. The first statistical approach yielded positive correlations between intra-pairs differences on the AP scale and intra-pair differences on two subscales of the TT: total rule violation (r(s)=0.41) and rule-violation-per-item-ratio (r(s)=0.38). Findings in categorically discordant pairs were consistent, showing within-pair differences on the same subtests (z-1.63, P=0.05, one-tailed and z=-1.60, P=0.05, one-tailed).
Conclusions: Findings confirm previous research suggesting ADHD to be a quantitative extreme on a continuum with executive functions being a cognitive marker of ADHD traits. Non-shared environmental factors appear to influence planning skills and inhibitory control.
C1 [Willfors, Charlotte; Poltrago, Lina; Berggren, Steve; Bolte, Sven] Karolinska Inst, Ctr Neurodev Disorders, Pediat Neuropsychiat Unit, Dept Womens & Childrens Hlth, Stockholm, Sweden.
[Poltrago, Lina] Prima Barn & Vuxenpsykiatri AB, Stockholm, Sweden.
[Berggren, Steve; Coco, Christina; Bolte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden.
[Anckarsater, Henrik] Univ Gothenburg, Gothenburg, Sweden.
[Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Ronald, Angelica] Birkbeck Univ London, Dept Psychol Sci, London, England.
RP Bolte, S (reprint author), Karolinska Inst, Ctr Neurodev Disorders, Neuropsychiat Unit, Stockholm, Sweden.
EM sven.bolte@ki.se
RI Ronald, Angelica/C-7812-2009
OI Ronald, Angelica/0000-0002-9576-2176
CR Achenbach T., 2003, MANUAL FOR THE ASEBA
Achenbach TM, 2001, MANUAL FOR THE ASEBA
Aman CJ, 1998, DEV PSYCHOL, V34, P956, DOI 10.1037//0012-1649.34.5.956
American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
Anokhin AP, 2010, NEUROSCI LETT, V472, P119, DOI 10.1016/j.neulet.2010.01.067
Ardila A, 2005, DEV NEUROPSYCHOL, V28, P539, DOI 10.1207/s15326942dn2801_5
Barkley R. A., 1998, ATTENTION DEFICITS H
Barkley Russell A, 2010, J Clin Psychiatry, V71, pe17, DOI 10.4088/JCP.9066tx1c
Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
Biederman J, 2008, J CLIN PSYCHIAT, V69, P1150
Burt SA, 2012, BEHAV GENET, V42, P711, DOI 10.1007/s10519-012-9545-y
Castellanos FX, 2003, AM J PSYCHIAT, V160, P1693, DOI 10.1176/appi.ajp.160.9.1693
Chou LN, 2010, BEHAV GENET, V40, P22, DOI 10.1007/s10519-009-9299-3
Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
Dean D. C., 2001, D KEFS EXAMINERS MAN
De Paepe ME, 2013, PEDIATR DEVEL PATHOL, V16, P237, DOI 10.2350/13-03-1315-MISC.1
Derks EM, 2006, COMPR PSYCHIAT, V47, P116, DOI 10.1016/j.comppsych.2005.05.006
Galeria C., 2013, J PEDIATR IN PRESS
Greven CU, 2011, J ABNORM CHILD PSYCH, V39, P265, DOI 10.1007/s10802-010-9451-9
Groen-Blokhuis MM, 2011, J AM ACAD CHILD PSY, V50, P1247, DOI 10.1016/j.jaac.2011.09.007
Happe F., 2006, BRAIN COGNITION, V61, P26
Heaton S. K., 1993, WISCONSIN CARD SORTI
Hultman CM, 2007, J AM ACAD CHILD PSY, V46, P370, DOI 10.1097/01.chi.0000246059.62706.22
Johnson S, 2010, J AM ACAD CHILD PSY, V49, P453, DOI 10.1016/j.jaac.2010.02.002
Jurado MB, 2007, NEUROPSYCHOL REV, V17, P213, DOI 10.1007/s11065-007-9040-z
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
Klorman R, 1999, J AM ACAD CHILD PSY, V38, P1148, DOI 10.1097/00004583-199909000-00020
Larsson B, 1999, EUR CHILD ADOLES PSY, V8, P24
Larsson H, 2012, J CHILD PSYCHOL PSYC, V53, P73, DOI 10.1111/j.1469-7610.2011.02467.x
Lehn M., 2007, J AM ACAD CHILD ADOL, V46, P83
Mann JR, 2011, J ATTEN DISORD, V15, P667, DOI 10.1177/1087054710370566
Nomura Y, 2012, ARCH PEDIAT ADOL MED, V166, P337, DOI 10.1001/archpediatrics.2011.784
Muriel Lezak D, 2004, NEUROPSYCHOLOGICAL A
Nikolas MA, 2010, J ABNORM PSYCHOL, V119, P1, DOI 10.1037/a0018010
Pearsall-Jones J. G., 2008, Journal of Pediatric Neurology, V6, P209
Pearsall-Jones JG, 2009, TWIN RES HUM GENET, V12, P381, DOI 10.1375/twin.12.4.381
PENNINGTON BF, 1993, DEV PSYCHOL, V29, P511, DOI 10.1037/0012-1649.29.3.511
Plommin R., 1987, INT J EPIDEMIOL, V40, P563
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
Preacher K. J., 2002, CALCULATION FOR THE
Romine CB, 2004, ARCH CLIN NEUROPSYCH, V19, P1027, DOI 10.1016/j.acn.2003.12.009
Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
Sarsour K, 2011, J INT NEUROPSYCH SOC, V17, P120, DOI 10.1017/S1355617710001335
Sergeant JA, 2002, BEHAV BRAIN RES, V130, P3, DOI 10.1016/S0166-4328(01)00430-2
Sharp WS, 2003, J AM ACAD CHILD PSY, V42, P93, DOI 10.1097/01.CHI.0000024903.60748.F4
Simon V, 2009, BRIT J PSYCHIAT, V194, P204, DOI 10.1192/bjp.bp.107.048827
Smalley SL, 2005, AM J MED GENET B, V135B, P79, DOI 10.1002/ajmg.b.30141
Sonuga-Barke EJS, 2010, J AM ACAD CHILD PSY, V49, P345, DOI 10.1016/j.jaac.2009.12.018
Steinmetz JP, 2011, CLIN NEUROPSYCHOL, V25, P652, DOI 10.1080/13854046.2011.568525
Thaper A., 2011, ARCH DIS CHILD, V97, P260
Tripp G, 2009, NEUROPHARMACOLOGY, V57, P579, DOI 10.1016/j.neuropharm.2009.07.026
Turkheimer E, 2000, PSYCHOL BULL, V126, P78, DOI 10.1037//0033-2909.126.1.78
van 't Ent D, 2009, NEUROSCIENCE, V164, P16, DOI 10.1016/j.neuroscience.2009.01.056
Wechsler D., 2004, THE WECHSLER INTELLI
Wechsler D., 2008, THE WECHSLER ADULT I
Wiers RW, 1998, J ABNORM CHILD PSYCH, V26, P415, DOI 10.1023/A:1022643617017
Wilcutt E. G., 2012, NEUROTHERAPEUTICS, V9, P490, DOI DOI 10.1007/S13311-012-0135-8
Wyendt L., 1994, DEVELOP NEUROPSYCHOL, V10, P27
Zook NA, 2004, BRAIN COGNITION, V56, P286, DOI 10.1016/j.bandc.2004.07.003
NR 60
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 2047-3869
EI 2047-3877
J9 INT J DEV DISABIL
JI Int. J. Dev. Disabil.
PD JUL
PY 2014
VL 60
IS 3
BP 163
EP 173
DI 10.1179/2047387714Y.0000000041
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK4YG
UT WOS:000338429900006
ER
PT J
AU Kretschmer, A
Lampmann, SA
Altgassen, M
AF Kretschmer, Anett
Lampmann, Sara-Ann
Altgassen, Mareike
TI Relations between moral reasoning, theory of mind and executive
functions in children with autism spectrum disorders
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE moral reasoning; executive functioning; autism spectrum disorders
ID PERVASIVE DEVELOPMENTAL DISORDERS; WORKING-MEMORY;
INDIVIDUAL-DIFFERENCES; INHIBITORY CONTROL; ASPERGER-SYNDROME;
SOCIAL-BEHAVIOR; EMPATHY; JUDGMENT; ADULTS; COGNITION
AB The aims of the present study were to investigate relations between moral reasoning, executive functioning and Theory of Mind in children with autism spectrum disorders (ASD) compared to typically developing children and to apply the dual aspect theory of Lind (1978, 2008) to moral reasoning in individuals with and without ASD. Overall, 21 children with ASD (age: M=10.22, SD=1.55) and 21 controls (age: M=9.83, SD=2.36) participated and completed the Moral Reasoning Test for children from Zierer (2006), which tests affective and cognitive aspects of moral reasoning. In addition, participants completed two Theory of Mind tasks, a working memory and an inhibition test. Correlational analyses revealed significant relations between cognitive moral reasoning and inhibitory control as well as between Theory of Mind and inhibition for the ASD group. Thus, inhibitory control, but not working memory and Theory of Mind, might be one key mechanism underlying moral reasoning, and possibly ToM development in children with ASD. Analyses of variance revealed no significant differences in cognitive and affective aspects of moral reasoning between individuals with ASD and typically developing children. Both groups did also not differ in Theory of Mind and executive functioning. Findings are discussed in light of the heterogeneous literature.
C1 [Kretschmer, Anett; Lampmann, Sara-Ann; Altgassen, Mareike] Tech Univ Dresden, Dresden, Germany.
[Altgassen, Mareike] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
RP Kretschmer, A (reprint author), Tech Univ Dresden, Dresden, Germany.
EM anett.kretschmer@tu-dresden.de
RI Altgassen, Mareike/J-3048-2012
CR American Psychiatric Association (APA), 2000, DIAGNOSTIC AND STATI
Baird JA, 2004, NEW DIR CHILD ADOLES, V103, P37, DOI 10.1002/cd.96
Barnes JL, 2009, AUTISM RES, V2, P148, DOI 10.1002/aur.79
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Blair J. R. J., 1996, J AUTISM DEVELOP DIS, V26, P571, DOI DOI 10.1007/BF02172277
Bolte S, 2006, DIAGNOSTISCHES INTER
Bolte S., 2006, FRAGEBOGEN ZUR SOZIA
Carlson SM, 2004, J EXP CHILD PSYCHOL, V87, P299, DOI 10.1016/j.jecp.2004.01.002
Carlson SM, 2002, INFANT CHILD DEV, V11, P73, DOI 10.1002/icd.298
Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
Cottone J, 2007, J SCI STUD RELIG, V46, P37, DOI 10.1111/j.1468-5906.2007.00339.x
Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0
Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X
Golan O, 2006, SOC NEUROSCI-UK, V1, P111, DOI 10.1080/17470910600980986
Grant CM, 2005, AUTISM, V9, P317, DOI 10.1177/1362361305055418
Happe F., 1994, AUTISM AN INTRODUCTI
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Hilton C., 2007, RES AUTISM SPECT DIS, V1, P146
Hughes C, 1997, EUR CHILD ADOLES PSY, V6, P191
Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x
Joseph RM, 2004, DEV PSYCHOPATHOL, V16, P137, DOI 10.1017/S095457940404444X
Kleinhans N, 2005, DEV NEUROPSYCHOL, V27, P379, DOI 10.1207/s15326942dn2703_5
Kohlberg L., 1984, PSYCHOLOGY OF MORAL
Kohlberg L., 1964, REV CHILD DEV RES, V1, P381
Kohlberg L., 1981, THE PHILOSOPHY OF MO
Leslie AM, 2006, SOC NEUROSCI, V1, P270, DOI 10.1080/17470910600992197
Lind G, 1978, SOZIALISATION MORAL, P171
Lind G., 2008, CONTEMPORARY PHILOSO
Mathersul D, 2013, J CLIN EXP NEUROPSYC, V35, P655, DOI 10.1080/13803395.2013.809700
Moore AB, 2008, PSYCHOL SCI, V19, P549, DOI 10.1111/j.1467-9280.2008.02122.x
Moran JM, 2011, P NATL ACAD SCI USA, V108, P2688, DOI 10.1073/pnas.1011734108
Ozonoff S, 2001, J AUTISM DEV DISORD, V31, P257, DOI 10.1023/A:1010794902139
OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x
Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7
Perner J., 1991, UNDERSTANDING THE RE
Petermann F, 2008, HAMBURG WECHSLER INT
Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
Roth-Hanania R, 2000, INFANT YOUNG CHILD, V13, P1
Ruhl D, 2004, DIAGNOSTISCHE BEOBAC
Russell J., 1997, AUTISM EXECUTIVE DIS, P256
Scambler DJ, 2007, J AUTISM DEV DISORD, V37, P553, DOI 10.1007/s10803-006-0186-y
Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x
Shulman C, 2012, J AUTISM DEV DISORD, V42, P1364, DOI 10.1007/s10803-011-1369-8
Smetana JG, 2012, DEV PSYCHOL, V48, P1144, DOI 10.1037/a0025891
Takeda T, 2007, PSYCHIAT CLIN NEUROS, V61, P407, DOI 10.1111/j.1440-1819.2007.01678.x
WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
Young L, 2007, P NATL ACAD SCI USA, V104, P8235, DOI 10.1073/pnas.0701408104
Zalla T, 2011, COGNITION, V121, P115, DOI 10.1016/j.cognition.2011.06.004
Zierer K., 2006, KONNEN KINDER MORAL
Zimmermann P., 2007, TESTBATTERIE ZUR AUF
NR 55
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 2047-3869
EI 2047-3877
J9 INT J DEV DISABIL
JI Int. J. Dev. Disabil.
PD JUL
PY 2014
VL 60
IS 3
BP 174
EP 183
DI 10.1179/2047387714Y.0000000045
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK4YG
UT WOS:000338429900007
ER
PT J
AU Altgassen, M
Koch, A
AF Altgassen, Mareike
Koch, Andrea
TI Impact of inhibitory load on remembering delayed intentions in autism
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; PDD; prospective memory; executive function; inhibition
ID PROSPECTIVE MEMORY; SPECTRUM DISORDER; EXECUTIVE FUNCTIONS;
RETROSPECTIVE-MEMORY; FUNCTIONING AUTISM; ASPERGERS-SYNDROME; ADULTS;
CHILDREN; RECOGNITION; RETRIEVAL
AB Objective: Research on prospective memory (PM) in autism spectrum disorders (ASD) is scarce and inconsistent. Differences in results have been attributed to differences in executive control demands of the respective PM tasks. However, so far no study has systematically and experimentally manipulated executive control load. The present study set out to explore the impact of varying inhibitory control demands on PM performance in ASD.
Method: Twenty-two adults with ASD and 22 age-, gender- and cognitive ability-matched controls were asked to work on a computerised word categorization task into which an event-based PM task was embedded. In addition, they were required to work on a task that put either low or high load on inhibitory resources.
Results: With regards to the event-based PM task, no significant effects emerged. Controls outperformed individuals with ASD on the ongoing task performance and ongoing task performance varied with inhibition load. Similarly, inhibition load affected performance on the inhibition task; here, no group effects were found.
Conclusion: Findings suggest spared event-based PM performance in ASD regardless of inhibition load. However, results might be limited by ceiling effects and future studies are needed to investigate to explore inhibition effects using more difficult tasks.
C1 [Altgassen, Mareike] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6500 HE Nijmegen, Netherlands.
[Altgassen, Mareike; Koch, Andrea] Tech Univ Dresden, Dept Psychol, Dresden, Germany.
RP Altgassen, M (reprint author), Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, POB 9104, NL-6500 HE Nijmegen, Netherlands.
EM a.altgassen@donders.ru.nl
RI Altgassen, Mareike/J-3048-2012
CR Altgassen M., J ATTENT DISOR
Altgassen M, 2012, J AUTISM DEV DISORD, V42, P2141, DOI 10.1007/s10803-012-1466-3
Altgassen M, 2010, J NEURODEV DISORD, V2, P2, DOI 10.1007/s11689-009-9030-y
Altgassen M, 2009, BRAIN IMPAIR, V10, P52
Altgassen M, 2008, J CLIN EXP NEUROPSYC, V30, P777, DOI 10.1080/13803390701779552
(APA) APA, 2000, DIAGN STAT MAN MENT
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bowler DA, 2008, NEUROPSYCHOLOGIA, V46, P993, DOI 10.1016/j.neuropsychologia.2007.12.004
Bowler DM, 1997, NEUROPSYCHOLOGIA, V35, P65, DOI 10.1016/S0028-3932(96)00054-1
Bowler DM, 2000, J AUTISM DEV DISORD, V30, P295, DOI 10.1023/A:1005575216176
Bowler DM, 2000, J ABNORM PSYCHOL, V109, P663, DOI 10.1037//0021-843X.109.4.663
Brandimonte MA, 2011, MEMORY, V19, P56, DOI 10.1080/09658211.2010.535657
Bull R, 2008, COGNITION, V107, P663, DOI 10.1016/j.cognition.2007.07.015
Burgess PW, 2011, NEUROPSYCHOLOGIA, V49, P2246, DOI 10.1016/j.neuropsychologia.2011.02.014
Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
Einstein G. O., 1996, PROSPECTIVE MEMORY T, P115
Ellis J., 1996, PROSPECTIVE MEMORY T, P1
Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Kliegel M, 2011, NEUROPSYCHOLOGIA, V49, P2166, DOI 10.1016/j.neuropsychologia.2011.01.024
Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
Mackinlay R, 2006, BRAIN COGNITION, V61, P14, DOI 10.1016/j.bandc.2005.12.006
Mannhaupt H.-R., 1994, HDB DEUTSCHSPRACHIGE, P86
Marsh RL, 2002, J EXP PSYCHOL LEARN, V28, P652, DOI 10.1037//0278-7393.28.4.652
McDaniel MA, 2000, APPL COGNITIVE PSYCH, V14, pS127, DOI 10.1002/acp.775
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
Ozonoff S, 1997, J AUTISM DEV DISORD, V27, P59, DOI 10.1023/A:1025821222046
OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x
Ozonoff S, 2004, J AUTISM DEV DISORD, V34, P139, DOI 10.1023/B:JADD.0000022605.81989.cc
Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Schopler E., 1995, LEARNING COGNITION A, V243-267
SIMON JR, 1990, ACTA PSYCHOL, V73, P159, DOI 10.1016/0001-6918(90)90077-S
Smith RE, 2004, J EXP PSYCHOL LEARN, V30, P756, DOI 10.1037/0278-7393.30.4.756
Von Aster M. G., 2006, WESCHSLER INTELLIGEN
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
West R, 2005, NEUROPSYCHOLOGIA, V43, P418, DOI 10.1016/j.neuropsychologia.2004.06.012
West R, 2011, NEUROPSYCHOLOGIA, V49, P2233, DOI 10.1016/j.neuropsychologia.2010.12.028
WILLIAMS D, 2013, CHEM IND LONDON, V77, P43
NR 39
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 2047-3869
EI 2047-3877
J9 INT J DEV DISABIL
JI Int. J. Dev. Disabil.
PD JUL
PY 2014
VL 60
IS 3
BP 198
EP 204
DI 10.1179/2047387714Y.0000000042
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK4YG
UT WOS:000338429900009
ER
PT J
AU Martin, J
Cooper, M
Hamshere, ML
Pocklington, A
Scherer, SW
Kent, L
Gill, M
Owen, MJ
Williams, N
O'Donovan, MC
Thapar, A
Holmans, P
AF Martin, Joanna
Cooper, Miriam
Hamshere, Marian L.
Pocklington, Andrew
Scherer, Stephen W.
Kent, Lindsey
Gill, Michael
Owen, Michael J.
Williams, Nigel
O'Donovan, Michael C.
Thapar, Anita
Holmans, Peter
TI Biological Overlap of Attention-Deficit/Hyperactivity Disorder and
Autism Spectrum Disorder: Evidence From Copy Number Variants
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE ADHD; ASD; pathway analysis; CNVs; comorbidity
ID DEFICIT-HYPERACTIVITY-DISORDER; GENOME-WIDE ANALYSIS;
MENTAL-RETARDATION; TWIN SAMPLE; ADHD; DUPLICATIONS; ASSOCIATION;
RELIABILITY; INTERVIEW; DELETIONS
AB Objective: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share biological underpinnings. Method: We compared copy number variant (CNV) data from 727 children with ADHD and 5,081 population controls to data from 996 individuals with ASD and an independent set of 1,287 controls. Using pathway analyses, we investigated whether CNVs observed in individuals with ADHD have an impact on genes in the same biological pathways as on those observed in individuals with ASD. Results: The results suggest that the biological pathways affected by CNVs in ADHD overlap with those affected by CNVs in ASD more than would be expected by chance. Moreover, this was true even when specific CNV regions common to both disorders were excluded from the analysis. After correction for multiple testing, genes involved in 3 biological processes (nicotinic acetylcholine receptor signalling pathway, cell division, and response to drug) showed significant enrichment for case CNV hits in the combined ADHD and ASD sample. Conclusion: The results of this study indicate the presence of significant overlap of shared biological processes disrupted by large rare CNVs in children with these 2 neurodevelopmental conditions.
C1 [Martin, Joanna; Cooper, Miriam; Hamshere, Marian L.; Pocklington, Andrew; Owen, Michael J.; Williams, Nigel; O'Donovan, Michael C.; Thapar, Anita; Holmans, Peter] Cardiff Univ, MRC, Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci,Sch Med, Cardiff CF24 4HQ, S Glam, Wales.
[Scherer, Stephen W.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Scherer, Stephen W.] Univ Toronto, Toronto, ON M5S 1A1, Canada.
[Kent, Lindsey] Univ St Andrews, Bute Med Sch, St Andrews KY16 9AJ, Fife, Scotland.
[Gill, Michael] Trinity Ctr Hlth Sci, Dublin, Ireland.
RP Martin, J (reprint author), Cardiff Univ, MRC, Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci,Sch Med, Hadyn Ellis Bldg,Maindy Rd, Cardiff CF24 4HQ, S Glam, Wales.
RI Scherer, Stephen /B-3785-2013; Holmans, Peter/F-4518-2015
OI Scherer, Stephen /0000-0002-8326-1999; Holmans,
Peter/0000-0003-0870-9412
FU Medical Research Council (UK); Baily Thomas Charitable Trust; Wellcome
Trust and Action Research; University of Toronto McLaughlin Centre;
Canadian Institutes of Health Research; Genome Canada
FX This work has been supported by the Medical Research Council (UK), Baily
Thomas Charitable Trust, the Wellcome Trust and Action Research, the
University of Toronto McLaughlin Centre, the Canadian Institutes of
Health Research, and Genome Canada.
CR Angold A, 2000, J AM ACAD CHILD PSY, V39, P39, DOI 10.1097/00004583-200001000-00015
Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
Bult CJ, 2008, NUCLEIC ACIDS RES, V36, pD724, DOI 10.1093/nar/gkm961
Burton PR, 2007, NATURE, V447, P661, DOI 10.1038/nature05911
Conners CK, 1998, J ABNORM CHILD PSYCH, V26, P279, DOI 10.1023/A:1022606501530
Cooper M, 2014, EUR CHILD ADOLES PSY, V23, P23, DOI 10.1007/s00787-013-0398-6
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Girirajan S, 2011, PLOS GENET, V7, P11
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
Hannes FD, 2009, J MED GENET, V46, P223, DOI 10.1136/jmg.2007.055202
Harris MA, 2004, NUCLEIC ACIDS RES, V32, pD258, DOI 10.1093/nar/gkh036
Holmes J, 2004, BRIT J PSYCHIAT, V184, P74, DOI 10.1192/bjp.184.1.74
Irtgason A, 2009, MOL PSYCHIATR, V16, P17
Kanehisa M, 2012, NUCLEIC ACIDS RES, V40, pD109, DOI 10.1093/nar/gkr988
Kirov G, 2011, MOL PSYCHIATR, V17, P142
Lee SH, 2013, NAT GENET, V45, P984, DOI 10.1038/ng.2711
Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Mi HY, 2013, NUCLEIC ACIDS RES, V41, pD377, DOI 10.1093/nar/gks1118
Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Raychaudhuri S, 2010, PLOS GENET, V6, P9
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Sharp AJ, 2008, NAT GENET, V40, P322, DOI 10.1038/ng.93
Stergiakouli E, 2012, AM J PSYCHIAT, V169, P186, DOI 10.1176/appi.ajp.2011.11040551
Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
Ullmann R, 2007, HUM MUTAT, V28, P674, DOI 10.1002/humu.20546
Wechsler D., 1992, WECHSLER INTELLIGENC
Wechsler D., 2004, WECHSLER INTELLIGENC
Williams NM, 2012, AM J PSYCHIAT, V169, P195, DOI 10.1176/appi.ajp.2011.11060822
Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
NR 41
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD JUL
PY 2014
VL 53
IS 7
BP 761
EP 770
DI 10.1016/j.jaac.2014.03.004
PG 10
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AK2SI
UT WOS:000338269400009
PM 24954825
ER
PT J
AU Szatkiewicz, JP
O'Dushlaine, C
Chen, G
Chambert, K
Moran, JL
Neale, BM
Fromer, M
Ruderfer, D
Akterin, S
Bergen, SE
Kahler, A
Magnusson, PKE
Kim, Y
Crowley, JJ
Rees, E
Kirov, G
O'Donovan, MC
Owen, MJ
Walters, J
Scolnick, E
Sklar, P
Purcell, S
Hultman, CM
McCarroll, SA
Sullivan, PF
AF Szatkiewicz, J. P.
O'Dushlaine, C.
Chen, G.
Chambert, K.
Moran, J. L.
Neale, B. M.
Fromer, M.
Ruderfer, D.
Akterin, S.
Bergen, S. E.
Kaehler, A.
Magnusson, P. K. E.
Kim, Y.
Crowley, J. J.
Rees, E.
Kirov, G.
O'Donovan, M. C.
Owen, M. J.
Walters, J.
Scolnick, E.
Sklar, P.
Purcell, S.
Hultman, C. M.
McCarroll, S. A.
Sullivan, P. F.
TI Copy number variation in schizophrenia in Sweden
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; DE-NOVO CNVS; BIPOLAR DISORDER;
PSYCHIATRIC-DISORDERS; GENES; GENETICS; RISK; VARIANTS; DISEASE;
PARTICIPATION
AB Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetrance and pleiotropic effects. Identification of additional recurrent CNVs and biological pathways enriched for SCZ CNVs requires greater sample sizes. We conducted a genome-wide survey for CNVs associated with SCZ using a Swedish national sample (4719 cases and 5917 controls). High-confidence CNV calls were generated using genotyping array intensity data, and their effect on risk of SCZ was measured. Our data confirm increased burden of large, rare CNVs in SCZ cases as well as significant associations for recurrent 16p11.2 duplications, 22q11.2 deletions and 3q29 deletions. We report a novel association for 17q12 duplications (odds ratio = 4.16, P = 0.018), previously associated with autism and mental retardation but not SCZ. Intriguingly, gene set association analyses implicate biological pathways previously associated with SCZ through common variation and exome sequencing (calcium channel signaling and binding partners of the fragile X mental retardation protein). We found significantly increased burden of the largest CNVs (>500 kb) in genes present in the postsynaptic density, in genomic regions implicated via SCZ genome-wide association studies and in gene products localized to mitochondria and cytoplasm. Our findings suggest that multiple lines of genomic inquiry-genome-wide screens for CNVs, common variation and exonic variation-are converging on similar sets of pathways and/or genes.
C1 [Szatkiewicz, J. P.; Chen, G.; Kim, Y.; Crowley, J. J.; Sullivan, P. F.] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
[O'Dushlaine, C.; Chambert, K.; Moran, J. L.; Neale, B. M.; Bergen, S. E.; Scolnick, E.; Purcell, S.; McCarroll, S. A.] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA.
[Fromer, M.; Ruderfer, D.; Sklar, P.; Purcell, S.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Akterin, S.; Bergen, S. E.; Kaehler, A.; Magnusson, P. K. E.; Hultman, C. M.; Sullivan, P. F.] Karolinska Inst, Dept Med Epidemiol, Stockholm, Sweden.
[Rees, E.; Kirov, G.; O'Donovan, M. C.; Owen, M. J.; Walters, J.] Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales.
[McCarroll, S. A.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
RP Sullivan, PF (reprint author), Univ N Carolina, Dept Genet, CB 7264,5097 Genom Med Bldg, Chapel Hill, NC 27599 USA.
EM pfsulliv@med.unc.edu
FU NIMH [R01 MH077139, R01 MH095034, K01 MH093517]; Stanley Center for
Psychiatric Research; Stanley Medical Research Institute; Sylvan Herman
Foundation; Karolinska Institutet; Karolinska University Hospital;
Swedish Research Council; Swedish County Council; Soderstrom Konigska
Foundation; Netherlands Scientific Organization [NWO 645-000-003];
Medical Research Council (MRC) Centre Grant [G0800509]; Medical Research
Council (MRC) Program Grant [G0801418]; European Community
[HEALTH-F2-2010-241909]; MRC; MRC/Welsh Assembly Government; British
Medical Association
FX We are deeply grateful for the participation of all subjects
contributing to this research and to the team that conducted the
fieldwork (Emma Flordal-Thelander, Ann-Britt Holmgren, Marie Hallin,
Marie Lundin, Ann-Kristin Sundberg, Christina Pettersson, Radja
Satgunanthan-Dawoud, Sonja Hassellund, Malin Radstrom, Birgitta
Ohlander, Leila Nyren and Isabelle Kizling). Funding support was
provided by NIMH R01 MH077139 (Sullivan), NIMH R01 MH095034 (Sklar),
NIMH K01 MH093517 Szatklewicz), the Stanley Center for Psychiatric
Research, the Stanley Medical Research Institute, the Sylvan Herman
Foundation, the Karolinska Institutet, Karolinska University Hospital,
the Swedish Research Council, the Swedish County Council, the Soderstrom
Konigska Foundation and the Netherlands Scientific Organization (NWO
645-000-003). The work at UK was funded by Medical Research Council
(MRC) Centre (G0800509) and Program Grants (G0801418), the European
Community's Seventh Framework Programme (HEALTH-F2-2010-241909 (Project
EU-GEI), an MRC PhD Studentship to ER, a clinical research fellowship to
JTRW from the MRC/Welsh Assembly Government and the Margaret Temple
Award from the British Medical Association. The UK samples were
genotyped at the Broad Institute, USA, funded by a philanthropic gift to
the Stanley Center for Psychiatric Research. The funders had no role in
study design, execution, analysis and manuscript preparation. We thank
two anonymous reviewers for their helpful comments. All authors reviewed
and approved the final version of the manuscript. The corresponding
authors had access to the full data set.
CR Andersson RE, 2001, NEW ENGL J MED, V344, P808, DOI 10.1056/NEJM200103153441104
Bergen SE, 2012, MOL PSYCHIATR, V17, P880, DOI 10.1038/mp.2012.73
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Blake JA, 2011, NUCLEIC ACIDS RES, V39, pD842, DOI 10.1093/nar/gkq1008
Buizer-Voskamp JE, 2011, BIOL PSYCHIAT, V70, P655, DOI 10.1016/j.biopsych.2011.02.015
Chiurazzi P, 2008, EUR J HUM GENET, V16, P422, DOI 10.1038/sj.ejhg.5201994
Consortium TIS, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
COX DR, 1970, BIOMETRIKA, V57, P217, DOI 10.2307/2334957
Craddock N, 2013, LANCET, V381, P1654, DOI 10.1016/S0140-6736(13)60855-7
Croning MDR, 2009, NUCLEIC ACIDS RES, V37, pD846, DOI 10.1093/nar/gkn700
Dalman C, 2002, SOC PSYCH PSYCH EPID, V37, P527, DOI 10.1007/s00127-002-0582-3
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
Flicek P, 2013, NUCLEIC ACIDS RES, V41, pD48, DOI 10.1093/nar/gks1236
Hamshere ML, 2012, MOL PSYCHIATR, V18, P708
Handsaker RE, 2011, NAT GENET, V43, P269, DOI 10.1038/ng.768
Hansson LE, 1996, NEW ENGL J MED, V335, P242, DOI 10.1056/NEJM199607253350404
Hartge P, 2006, EPIDEMIOLOGY, V17, P252, DOI 10.1097/01.ede.0000209441.24307.92
HOLM S, 1979, SCAND J STAT, V6, P65
Hultman CM, 1999, BRIT MED J, V318, P421
Inlow JK, 2004, GENETICS, V166, P835, DOI 10.1534/genetics.166.2.835
Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
Jupe S, 2012, J THROMB HAEMOST, V10, P2399, DOI 10.1111/j.1538-7836.2012.04930.x
Kanehisa M, 2012, NUCLEIC ACIDS RES, V40, pD109, DOI 10.1093/nar/gkr988
Kendler Kenneth S., 1990, Psychiatric Genetics, V1, P45
Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
Knapp M, 2004, SCHIZOPHRENIA BULL, V30, P279
Korn JM, 2008, NAT GENET, V40, P1253, DOI 10.1038/ng.237
Kristjansson E, 1987, NORD PSYKIATR TIDSSK, V41, P229, DOI DOI 10.3109/08039488709103182
Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
Lewis BP, 2005, CELL, V120, P15, DOI 10.1016/j.cell.2004.12.035
Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
Lichtenstein P, 2006, TWIN RES HUM GENET, V9, P875, DOI 10.1375/183242706779462444
Maddatu TP, 2011, NUCLEIC ACIDS RES, V37, pD720
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
Manji H, 2012, NAT REV NEUROSCI, V13, P293, DOI 10.1038/nrn3229
McCarroll SA, 2008, NAT GENET, V40, P1166, DOI 10.1038/ng.238
McKusick VA, 2007, AM J HUM GENET, V80, P588, DOI 10.1086/514346
Mi HY, 2010, NUCLEIC ACIDS RES, V38, pD204, DOI 10.1093/nar/gkp1019
Morton LM, 2006, AM J EPIDEMIOL, V163, P197, DOI 10.1093/aje/kwj036
Murray RM, 2003, EPIDEMIOLOGY SCHIZOP
Najmabadi H, 2011, NATURE, V478, P57, DOI 10.1038/nature10423
Pagliarini DJ, 2008, CELL, V134, P112, DOI 10.1016/j.cell.2008.06.016
Project GO, 2012, NUCLEIC ACIDS RES, V40, pD559
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Purcell SM, 2014, NATURE, V506, P185, DOI 10.1038/nature12975
R Development Core Team, 2011, R LANG ENV STAT COMP
Raychaudhuri S, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001097
Rees E, 2013, MOL PSYCHIATR, V19, P37
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Robicsek O, 2013, MOL PSYCHIATR, V18, P1067, DOI 10.1038/mp.2013.67
Ruano D, 2010, AM J HUM GENET, V86, P113, DOI 10.1016/j.ajhg.2009.12.006
Ruderfer DM, 2013, EUR J HUM GENET, V21, P1007, DOI 10.1038/ejhg.2012.287
Saha S, 2005, PLOS MED, V2, P413, DOI 10.1371/journal.pmed.0020141
Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Schwartz S, 2010, PSYCHOL MED, V41, P1
Storey JD, 2003, P NATL ACAD SCI USA, V100, P9440, DOI 10.1073/pnas.1530509100
Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
Szatkiewicz JP, 2013, MOL PSYCHIATR, V18, P1178, DOI 10.1038/mp.2013.98
The Schizophrenia Psychiatric Genome-Wide Association Study C, 2011, NAT GENET, V43, P969
Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
WHO, 2008, GLOB BURD DIS 2004 U
Zammit S, 2003, AM J PSYCHIAT, V160, P2216, DOI 10.1176/appi.ajp.160.12.2216
NR 68
TC 11
Z9 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2014
VL 19
IS 7
BP 762
EP 773
DI 10.1038/mp.2014.40
PG 12
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AK1OV
UT WOS:000338185300005
PM 24776740
ER
PT J
AU Toma, C
Torrico, B
Hervas, A
Valdes-Mas, R
Tristan-Noguero, A
Padillo, V
Maristany, M
Salgado, M
Arenas, C
Puente, XS
Bayes, M
Cormand, B
AF Toma, C.
Torrico, B.
Hervas, A.
Valdes-Mas, R.
Tristan-Noguero, A.
Padillo, V.
Maristany, M.
Salgado, M.
Arenas, C.
Puente, X. S.
Bayes, M.
Cormand, B.
TI Exome sequencing in multiplex autism families suggests a major role for
heterozygous truncating mutations
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism spectrum disorder; exome sequencing; multiplex families; novel
candidate genes; rare genetic variants; truncating mutations
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; DEVELOPMENTAL DELAY; GENES;
SCHIZOPHRENIA; IDENTIFICATION; PHENOTYPES; 17P13.3; RISK; BTK
AB Autism is a severe neurodevelopmental disorder, the aetiology of which remains mainly unknown. Family and twin studies provide strong evidence that genetic factors have a major role in the aetiology of this disease. Recently, whole exome sequencing (WES) efforts have focused mainly on rare de novo variants in singleton families. Although these studies have provided pioneering insights, de novo variants probably explain only a small proportion of the autism risk variance. In this study, we performed exome sequencing of 10 autism multiplex families with the aim of investigating the role of rare variants that are coinherited in the affected sibs. The pool of variants selected in our study is enriched with genes involved in neuronal functions or previously reported in psychiatric disorders, as shown by Gene Ontology analysis and by browsing the Neurocarta database. Our data suggest that rare truncating heterozygous variants have a predominant role in the aetiology of autism. Using a multiple linear regression model, we found that the burden of truncating mutations correlates with a lower non- verbal intelligence quotient (NVIQ). Also, the number of truncating mutations that were transmitted to the affected sibs was significantly higher (twofold) than those not transmitted. Protein-protein interaction analysis performed with our list of mutated genes revealed that the postsynaptic YWHAZ is the most interconnected node of the network. Among the genes found disrupted in our study, there is evidence suggesting that YWHAZ and also the X-linked DRP2 may be considered as novel autism candidate genes.
C1 [Toma, C.; Torrico, B.; Tristan-Noguero, A.; Cormand, B.] Univ Barcelona, Dept Genet, Barcelona 08028, Spain.
[Toma, C.; Torrico, B.; Cormand, B.] Biomed Network Res Ctr Rare Dis CIBERER, Barcelona, Spain.
[Hervas, A.] Hosp Univ Mutua Terrassa, Child & Adolescent Mental Hlth Unit, Barcelona, Spain.
[Valdes-Mas, R.; Puente, X. S.] Univ Oviedo IUOPA, Dept Biochem & Mol Biol, Barcelona, Spain.
[Padillo, V.; Maristany, M.] Hosp San Juan Dios, Dev Disorders Unit UETD, Barcelona, Spain.
[Arenas, C.] Univ Barcelona, Dept Stat, Barcelona 08028, Spain.
[Bayes, M.] Natl Ctr Genom Anal CNAG, Barcelona, Spain.
[Cormand, B.] Univ Barcelona, Inst Biomed, Barcelona 08028, Spain.
RP Cormand, B (reprint author), Univ Barcelona, Fac Biol, Dept Genet, Avinguda Diagonal 643,Edifici Prevosti,3a Planta, Barcelona 08028, Spain.
EM bcormand@ub.edu
RI Toma, Claudio/L-7853-2014
OI Toma, Claudio/0000-0003-3901-7507
FU European Union [PIEF-GA-2009-254930]; AGAUR [2009SGR00971]; Fundacio La
Marato de TV3 [092010]; Fundacion Alicia Koplowitz; Ministerio de
Economia y Competitividad, Spain [SAF2012-33484, SAF2010-21165]
FX We are grateful to all families for their participation in our study. We
thank Patricia Romaris (Hospital Universitari Mutua de Terrassa) for
contributing to clinical delineation of patients and Lara Nonell and
Eulalia Puigdecanet (Servei d'Analisi de Micorarrays, IMIM-Hospital del
Mar, Parc de Recerca Biomedica de Barcelona) for their contribution to
the CNV studies. Exome sequencing services were provided by the National
Centre for Genomic Analysis (CNAG). CT was supported by the European
Union (Marie Curie, PIEF-GA-2009-254930) and BT by AGAUR (FI grant).
Financial support was received from 'Fundacio La Marato de TV3'
(092010), 'Fundacion Alicia Koplowitz', AGAUR (2009SGR00971) and
'Ministerio de Economia y Competitividad, Spain' (SAF2012-33484,
SAF2010-21165).
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
Arai T, 2011, J HUM GENET, V56, P577, DOI 10.1038/jhg.2011.61
BAILEY A, 1995, PSYCHOL MED, V25, P63
Brooks-Kayal A, 2010, BRAIN DEV-JPN, V32, P731, DOI 10.1016/j.braindev.2010.04.010
Bruno DL, 2010, J MED GENET, V47, P299, DOI 10.1136/jmg.2009.069906
Capra V, 2012, BMC MED GENET, V13, DOI 10.1186/1471-2350-13-93
Cardoso C, 2003, AM J HUM GENET, V72, P918, DOI 10.1086/374320
Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
Cheah PS, 2012, MOL PSYCHIATR, V17, P451, DOI 10.1038/mp.2011.158
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
English JA, 2011, BIOL PSYCHIAT, V69, P163, DOI 10.1016/j.biopsych.2010.06.031
Fajardo KVF, 2012, HUM MUTAT, V33, P609, DOI 10.1002/humu.22033
Foote Molly, 2012, Int J Biochem Mol Biol, V3, P152
Grover D, 2009, AM J MED GENET B, V150B, P977, DOI 10.1002/ajmg.b.30927
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
He Wen-zhi, 2012, Zhonghua Yixue Yichuanxue Zazhi, V29, P266, DOI 10.3760/cma.j.issn.1003-9406.2012.03.004
Ikeda M, 2008, HUM MOL GENET, V17, P3212, DOI 10.1093/hmg/ddn217
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jyonouchi H, 2008, EUR J PEDIATR, V167, P317, DOI 10.1007/s00431-007-0493-0
Kleppe R, 2011, SEMIN CELL DEV BIOL, V22, P713, DOI 10.1016/j.semcdb.2011.08.008
Kumar P, 2009, NAT PROTOC, V4, P1073, DOI 10.1038/nprot.2009.86
Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
Lord C, 2012, J CHILD PSYCHOL PSYC, V53, P490, DOI 10.1111/j.1469-7610.2012.02547.x
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Medina I, 2010, NUCLEIC ACIDS RES, V38, pW210, DOI 10.1093/nar/gkq388
Middleton FA, 2005, NEUROPSYCHOPHARMACOL, V30, P974, DOI 10.1038/sj.npp.1300674
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
Pers TH, 2011, GENET EPIDEMIOL, V35, P318, DOI 10.1002/gepi.20580
Puente XS, 2011, NATURE, V475, P101, DOI 10.1038/nature10113
Puffenberger EG, 2012, HUM MUTAT, V33, P1639, DOI 10.1002/humu.22237
Ramocki MB, 2010, AM J HUM GENET, V87, P857, DOI 10.1016/j.ajhg.2010.10.019
Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Sediva A, 2007, J CLIN IMMUNOL, V27, P640, DOI 10.1007/s10875-007-9123-x
Sherman DL, 2012, J NEUROSCI, V32, P9419, DOI 10.1523/JNEUROSCI.1220-12.2012
NR 45
TC 6
Z9 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2014
VL 19
IS 7
BP 784
EP 790
DI 10.1038/mp.2013.106
PG 7
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AK1OV
UT WOS:000338185300007
PM 23999528
ER
PT J
AU Zaits, MN
Rennert, OM
AF Zaits, M. N.
Rennert, O. M.
TI Identification of differentially expressed microRNAs across the
developing human brain
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE brain development; gene expression; microRNA; sex differences
ID SEX-DIFFERENCES; TRANSCRIPTION FACTORS; GENE-REGULATION; DISEASE;
NEUROSCIENCE; ANNOTATION; EVOLUTION; ROLES; RNA
AB We present a spatio-temporal assessment of microRNA (miRNA) expression throughout early human brain development. We assessed the prefrontal cortex, hippocampus and cerebellum of 18 normal human donor brains spanning infancy through adolescence by RNA-seq. We discovered differentially expressed miRNAs and broad miRNA patterns across both temporal and spatial dimensions, and between male and female prefrontal cortex. Putative target genes of the differentially expressed miRNAs were identified, which demonstrated functional enrichment for transcription regulation, synaptogenesis and other basic intracellular processes. Sex-biased miRNAs also targeted genes related to Wnt and transforming growth factor-beta pathways. The differentially expressed miRNA targets were highly enriched for gene sets related to autism, schizophrenia, bipolar disorder and depression, but not neurodegenerative diseases, epilepsy or other adult-onset psychiatric diseases. Our results suggest critical roles for the identified miRNAs in transcriptional networks of the developing human brain and neurodevelopmental disorders.
C1 [Zaits, M. N.; Rennert, O. M.] NICHHD, NIH, Bethesda, MD 20814 USA.
[Zaits, M. N.] Univ Cambridge, NIH, Biomed Scholars Program, Cambridge, England.
[Zaits, M. N.] Baylor Coll Med MSTP, Houston, TX USA.
RP Zaits, MN (reprint author), NICHHD, NIH, 49 Convent Dr,Bldg 49,Room 2C08, Bethesda, MD 20814 USA.
EM ziatsm@mail.nih.gov; rennerto@mail.nih.gov
FU National Institute of Child Health and Human Development, NIH; Baylor
College of Medicine Medical Scientist Training Program (MSTP);
NIH-Oxford/Cambridge Biomedical Scholars Program
FX We thank the Allen Institute for Brain Science. This work was supported
by the Intramural Research Program (IRP) of the National Institute of
Child Health and Human Development, NIH. MNZ was also supported by the
Baylor College of Medicine Medical Scientist Training Program (MSTP) and
the NIH-Oxford/Cambridge Biomedical Scholars Program. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Abel KM, 2010, INT REV PSYCHIATR, V22, P417, DOI 10.3109/09540261.2010.515205
Anders S, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-10-r106
Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
Button KS, 2013, NAT REV NEUROSCI, V14, P365, DOI 10.1038/nrn3475
Chen K, 2007, NAT REV GENET, V8, P93, DOI 10.1038/nrg1990
Freese JL, 2010, NEUROBIOL DIS, V38, P148, DOI 10.1016/j.nbd.2009.09.003
Hobert O, 2008, SCIENCE, V319, P1785, DOI 10.1126/science.1151651
Hu HY, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002327
Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
Jazin E, 2010, NAT REV NEUROSCI, V11, P9, DOI 10.1038/nrn2754
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Krieglstein K, 2011, TRENDS NEUROSCI, V34, P421, DOI 10.1016/j.tins.2011.06.002
Lewis BP, 2005, CELL, V120, P15, DOI 10.1016/j.cell.2004.12.035
Oldham MC, 2008, NAT NEUROSCI, V11, P1271, DOI 10.1038/nn.2207
Qureshi IA, 2012, NAT REV NEUROSCI, V13, P528, DOI 10.1038/nrn3234
Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
Robles JA, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-484
Shao NY, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-409
Somel M, 2010, GENOME RES, V20, P1207, DOI 10.1101/gr.106849.110
Somel M, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001214
Wall DP, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-50
Wang XW, 2008, RNA, V14, P1012, DOI 10.1261/rna.965408
Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
NR 23
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2014
VL 19
IS 7
BP 848
EP 852
DI 10.1038/mp.2013.93
PG 5
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AK1OV
UT WOS:000338185300014
ER
PT J
AU Lucas, R
Norbury, CF
AF Lucas, Rebecca
Norbury, Courtenay Frazier
TI Orthography facilitates vocabulary learning for children with autism
spectrum disorders (ASD)
SO QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
LA English
DT Article
DE Orthography; Reading; Vocabulary; Word learning; Autism spectrum
disorder
ID PICTURE BOOKS; COMPREHENSION DIFFICULTIES; WORD-RECOGNITION; LANGUAGE;
CONSOLIDATION; SPEECH; SLEEP; INFORMATION; ACQUISITION; INTEGRATION
AB This study investigated the extent to which children with autism spectrum disorders (ASD) can use orthography to facilitate vocabulary learning, as is the case for typically developing (TD) children. Forty-one children aged 7-12 years, 20 with a formal diagnosis of ASD and 21 TD peers, were taught 16 low-frequency concrete science words, such as "breccia". Half of the stimuli had the written word presented alongside a picture of the target item (orthography present: OP) while the remaining items were taught with orthography absent (OA). During the learning phase, eye movements were recorded; there were no group differences in the time spent fixating the written form. Production, comprehension, and recognition of orthographic forms of new words were assessed immediately after learning and again after a 24-hour delay. The vocabulary learning of both groups was facilitated by the presence of orthography. Overall, the groups did not differ in comprehension of new words or recognition of new orthographic forms, although the children with ASD demonstrated superior phonological learning (as measured by a picture naming task) relative to TD peers. Additionally, both groups retained or increased new knowledge after 24 hours. The results suggest that presenting the written form during oral vocabulary teaching will enhance learning and provide a mechanism for children with ASD to increase word knowledge despite potential limitations in social learning.
C1 [Lucas, Rebecca; Norbury, Courtenay Frazier] Univ London, Dept Psychol, Egham TW20 0EX, Surrey, England.
RP Lucas, R (reprint author), Univ London, Dept Psychol, Egham TW20 0EX, Surrey, England.
EM rebecca.lucas.2010@rhul.ac.uk
FU Royal Holloway, University of London
FX This research was funded by a Reid Scholarship from Royal Holloway,
University of London.
CR Akechi H, 2011, RES AUTISM SPECT DIS, V5, P1230, DOI 10.1016/j.rasd.2011.01.013
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
[Anonymous], 1992, INT STAT CLASS DIS R
BaronCohen S, 1997, CHILD DEV, V68, P48
Brown H, 2012, J EXP CHILD PSYCHOL, V112, P56, DOI 10.1016/j.jecp.2011.11.010
Brown HM, 2013, J AUTISM DEV DISORD, V43, P932, DOI 10.1007/s10803-012-1638-1
Cain K, 2003, J CHILD LANG, V30, P681, DOI 10.1017/S0305000903005713
CARNINE D, 1984, READ RES QUART, V19, P188, DOI 10.2307/747362
Cunningham A., 2001, TEACHING LEARNING VO, P45
de Marchena A, 2011, COGNITION, V119, P96, DOI 10.1016/j.cognition.2010.12.011
Dumay N, 2007, PSYCHOL SCI, V18, P35, DOI 10.1111/j.1467-9280.2007.01845.x
Ehri L. C., 1998, READING WRITING Q, V14, P135, DOI [10.1080/1057356980140202, DOI 10.1080/1057356980140202]
Ehri L. C., 1992, READING RES Q, V27, P13
Ehri LC, 2005, SCI STUD READ, V9, P167, DOI 10.1207/s1532799xssr0902_4
Frost L. A., 1994, PICTURE EXCHANGE COM
Gardner M., 1990, RECEPTIVE ONE WORLD
Gardner M., 1990, EXPRESSIVE ONE WORLD
Gliga T, 2012, CHILD DEV, V83, P926, DOI 10.1111/j.1467-8624.2012.01750.x
Henderson L, 2013, J EXP CHILD PSYCHOL, V116, P572, DOI 10.1016/j.jecp.2013.07.004
Henderson L., DEV SCI IN PRESS
Henderson LM, 2012, DEVELOPMENTAL SCI, V15, P674, DOI 10.1111/j.1467-7687.2012.01172.x
HERMAN PA, 1987, READ RES QUART, V22, P263, DOI 10.2307/747968
Hudry K, 2010, INT J LANG COMM DIS, V45, P681, DOI 10.3109/13682820903461493
Hulme C, 2007, J EXP CHILD PSYCHOL, V96, P150, DOI 10.1016/j.jecp.2006.09.002
JENKINS JR, 1984, AM EDUC RES J, V21, P767, DOI 10.3102/00028312021004767
Jones CRG, 2009, NEUROPSYCHOLOGY, V23, P718, DOI 10.1037/a0016360
Kelly DJ, 2013, DEVELOPMENTAL SCI, V16, P56, DOI 10.1111/j.1467-7687.2012.01188.x
Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x
Kuhl PK, 2007, DEVELOPMENTAL SCI, V10, P110, DOI 10.1111/j.1467-7687.2007.00572.x
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luyster R, 2009, DEV PSYCHOL, V45, P1774, DOI 10.1037/a0016223
McDuffie A., 2006, 1 LANGUAGE, V26, P421, DOI 10.1177/0142723706067438
Mengoni SE, 2013, J CHILD LANG, V40, P221, DOI 10.1017/S0305000912000396
Muneaux M, 2004, LANG COGNITIVE PROC, V19, P641, DOI 10.1080/016909604444000052
NAGY WE, 1985, READ RES QUART, V20, P233, DOI 10.2307/747758
Nation K., 2007, ADV SPEECH LANGUAGE, V9, P131, DOI [10.1080/14417040601145166, DOI 10.1080/14417040601145166]
Nation K, 1998, J MEM LANG, V39, P85, DOI 10.1006/jmla.1998.2564
Nation K, 2006, J AUTISM DEV DISORD, V36, P911, DOI 10.1007/s10803-006-0130-1
Nelson J. R., 2005, WRITTEN LANGUAGE LIT, V8, P25, DOI DOI 10.1075/WLL.8.2.04NEL
NICHD, 2010, PUT READ 1 KIND GRAD
Norbury C, 2011, SCI STUD READ, V15, P191, DOI 10.1080/10888431003623553
Norbury CF, 2010, NEUROPSYCHOLOGIA, V48, P4012, DOI 10.1016/j.neuropsychologia.2010.10.015
Parish-Morris J, 2007, CHILD DEV, V78, P1265, DOI 10.1111/j.1467-8624.2007.01065.x
POTTS GR, 1989, COGNITIVE PSYCHOL, V21, P303, DOI 10.1016/0010-0285(89)90011-X
Preissler MA, 2008, AUTISM, V12, P231, DOI 10.1177/1362361307088753
Preissler MA, 2005, COGNITION, V97, pB13, DOI 10.1016/j.cognition.2005.01.008
Randi J, 2010, J AUTISM DEV DISORD, V40, P890, DOI 10.1007/s10803-010-0938-6
Rastle K, 2011, J EXP PSYCHOL LEARN, V37, P1588, DOI 10.1037/a0024833
REITSMA P, 1983, J EXP CHILD PSYCHOL, V36, P321, DOI 10.1016/0022-0965(83)90036-X
Remington AM, 2012, J ABNORM PSYCHOL, V121, P544, DOI 10.1037/a0027670
Ricketts J, 2009, Q J EXP PSYCHOL, V62, P1948, DOI 10.1080/17470210802696104
Ricketts J, 2008, J RES READ, V31, P117, DOI 10.1111/j.1467-9817.2007.00365.x
Rosenthal J, 2008, J EDUC PSYCHOL, V100, P175, DOI 10.1037/0022-0663.100.1.175
Sadoski M., 2005, READ WRIT Q, V21, P221, DOI [10.1080/10573560590949359, DOI 10.1080/10573560590949359]
Schneider W., 2002, E PRIME USERS GUIDE
Simcock G, 2008, INFANCY, V13, P687, DOI 10.1080/15250000802459102
Simcock G, 2006, DEV PSYCHOL, V42, P1352, DOI 10.1037/0012-1649.42.6.1352
Smith V, 2007, J SPEECH LANG HEAR R, V50, P149, DOI 10.1044/1092-4388(2007/013)
Snowling M., 2008, DOWN SYNDROME RES PR, V13, P62, DOI [10.3104/reviews/2066, DOI 10.3104/REVIEWS/2066]
Tamminen J, 2010, J NEUROSCI, V30, P14356, DOI 10.1523/JNEUROSCI.3028-10.2010
Tare M, 2010, J APPL DEV PSYCHOL, V31, P395, DOI 10.1016/j.appdev.2010.06.005
Torgesen J., 1999, TEST WORD READING EF
Wang HC, 2012, Q J EXP PSYCHOL, V65, P856, DOI 10.1080/17470218.2012.672996
Wechsler D, 1999, WECHSLER ABBREVIATED
NR 65
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1747-0218
EI 1747-0226
J9 Q J EXP PSYCHOL
JI Q. J. Exp. Psychol.
PD JUL
PY 2014
VL 67
IS 7
BP 1317
EP 1334
DI 10.1080/17470218.2013.859714
PG 18
WC Psychology, Biological; Physiology; Psychology; Psychology, Experimental
SC Psychology; Physiology
GA AJ9FP
UT WOS:000338013400005
PM 24313313
ER
PT J
AU Birnbaum, R
Jaffe, AE
Hyde, TM
Kleinman, JE
Weinberger, DR
AF Birnbaum, Rebecca
Jaffe, Andrew E.
Hyde, Thomas M.
Kleinman, Joel E.
Weinberger, Daniel R.
TI Prenatal Expression Patterns of Genes Associated With Neuropsychiatric
Disorders
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID OBSTETRIC COMPLICATIONS; HUMAN BRAIN; SCHIZOPHRENIA; RISK;
NEUROPATHOLOGY; TRANSCRIPTOME; METAANALYSIS; DISRUPTION; MUTATIONS;
ISOFORM
AB Objective: Neurodevelopmental disorders presumably involve events that occur during brain development. The authors hypothesized that neuropsychiatric disorders considered to be developmental in etiology are associated with susceptibility genes that are relatively upregulated during fetal life (i.e., differentially expressed).
Method: The authors investigated the presence of prenatal expression enrichment of susceptibility genes systematically, as composite gene sets associated with six neuropsychiatric disorders in the microarray-based "BrainCloud" dorsolateral prefrontal cortex transcriptome.
Results: Using a fetal/postnatal log2-fold change threshold of 0.5, genes associated with syndromic neurodevelopmental disorders (N=31 genes, p=3.37x10(-3)), intellectual disability (N=88 genes, p=5.53x10(-3)), and autism spectrum disorder (N=242 genes, p=3.45x10(-4)) were relatively, enriched in prenatal transcript abundance, compared with the overall transcriptome. Genes associated with schizophrenia by genome-wide association studies were not preferentially fetally expressed (N=106 genes, p=0.46), nor were genes associated with schizophrenia by exome sequencing (N=2.12 genes, p=0.21), but specific genes within copy-number variant regions associated with schizophrenia were relatively enriched in prenatal transcript abundance, and genes associated with schizophrenia by meta-analysis were functionally enriched for some neurodevelopmental processes. In contrast, genes associated with neurode-generative disorders were significantly underexpressed during fetal life (N=46 genes, p=1.67x10(-3)).
Conclusions: The authors found evidence for relative prenatal enrichment of putative susceptibility genes for syndromic neurodevelopmental disorders, intellectual disability, and autism spectrum disorder. Future transcriptome-level association studies should evaluate regions other than the dorsolateral prefrontal cortex, at other time points, and incorporate further RNA sequencing analyses.
C1 [Weinberger, Daniel R.] Lieber Inst Brain Dev, Baltimore, MD 21205 USA.
Johns Hopkins Sch Med, Dept Psychiat, Balitmore, MD USA.
Johns Hopkins Sch Med, Dept Neurol, Balitmore, MD USA.
Johns Hopkins Sch Med, Dept Neurosci, Balitmore, MD USA.
Johns Hopkins Sch Med, Inst Med Genet, Baltimore, MD 21205 USA.
RP Weinberger, DR (reprint author), Lieber Inst Brain Dev, Baltimore, MD 21205 USA.
EM drweinberger@libd.org
FU NIH [5T32MH015330-36]
FX Dr. Birnbaum receives support from an NIH T32, 5T32MH015330-36
CR Allen Institute for Brain Science, 2011, BRAINSP ATL DEV HUM
Brown Alan S, 2011, Front Psychiatry, V2, P63, DOI 10.3389/fpsyt.2011.00063
Buka SL, 1999, SCHIZOPHR RES, V39, P113, DOI 10.1016/S0920-9964(99)00109-7
Buka S. L., 1999, SCHIZOPHR RES, V39, P160
Cannon TD, 2008, BIOL PSYCHIAT, V64, P797, DOI 10.1016/j.biopsych.2008.04.012
Colantuoni C, 2011, NATURE, V478, P519, DOI 10.1038/nature10524
Davidson M, 1999, AM J PSYCHIAT, V156, P1328
DONE DJ, 1994, BRIT MED J, V309, P699
FEINBERG I, 1983, J PSYCHIAT RES, V17, P319, DOI 10.1016/0022-3956(82)90038-3
Geddes JR, 1995, BRIT J PSYCHIAT, V167, P786, DOI 10.1192/bjp.167.6.786
Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
Huffaker SJ, 2009, NAT MED, V15, P509, DOI 10.1038/nm.1962
Hyde TM, 2011, J NEUROSCI, V31, P11088, DOI 10.1523/JNEUROSCI.1234-11.2011
Jaaro-Peled H, 2009, TRENDS NEUROSCI, V32, P485, DOI 10.1016/j.tins.2009.05.007
Johnson MB, 2009, NEURON, V62, P494, DOI 10.1016/j.neuron.2009.03.027
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Kang YH, 2012, P NATL ACAD SCI USA, V109, P6042, DOI 10.1073/pnas.1203734109
Kao WT, 2010, P NATL ACAD SCI USA, V107, P15619, DOI 10.1073/pnas.1005410107
Kleinman JE, 2011, BIOL PSYCHIAT, V69, P140, DOI 10.1016/j.biopsych.2010.10.032
Lavin A, 2005, NEUROPSYCHOPHARMACOL, V30, P1426, DOI 10.1038/sj.npp.1300696
LEWIS SW, 1987, J PSYCHIAT RES, V21, P413, DOI 10.1016/0022-3956(87)90088-4
LIPSKA BK, 1993, DEV BRAIN RES, V75, P213, DOI 10.1016/0165-3806(93)90026-7
Lodge DJ, 2009, BEHAV BRAIN RES, V204, P306, DOI 10.1016/j.bbr.2009.01.031
MURRAY RM, 1987, BRIT MED J, V295, P681
Nakata K, 2009, P NATL ACAD SCI USA, V106, P15873, DOI 10.1073/pnas.0903413106
Nicodemus KK, 2008, MOL PSYCHIATR, V13, P873, DOI 10.1038/sj.mp.4002153
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
Susser E, 1996, ARCH GEN PSYCHIAT, V53, P25
Tan W, 2007, J BIOL CHEM, V282, P24343, DOI 10.1074/jbc.M702953200
Tao R, JAMA PSYCHI IN PRESS
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
WALKER EF, 1994, SCHIZOPHRENIA BULL, V20, P453
Weinberg SM, 2007, SCHIZOPHR RES, V89, P72, DOI 10.1016/j.schres.2006.09.002
WEINBERGER DR, 1987, ARCH GEN PSYCHIAT, V44, P660
Woodberry KA, 2008, AM J PSYCHIAT, V165, P579, DOI 10.1176/appi.ajp.2008.07081242
Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
Zhang ZH, 2013, J BIOL CHEM, V288, P42, DOI 10.1074/jbc.M112.427740
NR 38
TC 6
Z9 6
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD JUL
PY 2014
VL 171
IS 7
BP 758
EP 767
DI 10.1176/appi.ajp.2014.13111452
PG 10
WC Psychiatry
SC Psychiatry
GA AJ9AD
UT WOS:000337998300015
PM 24874100
ER
PT J
AU Skakkebk, A
Bojesen, A
Kristensen, MK
Cohen, A
Hougaard, DM
Hertz, JM
Fedder, J
Laurberg, P
Wallentin, M
Ostergaard, JR
Pedersen, AD
Gravholt, CH
AF Skakkebk, A.
Bojesen, A.
Kristensen, M. K.
Cohen, A.
Hougaard, D. M.
Hertz, J. M.
Fedder, J.
Laurberg, P.
Wallentin, M.
Ostergaard, J. R.
Pedersen, A. D.
Gravholt, C. H.
TI Neuropsychology and brain morphology in Klinefelter syndrome - the
impact of genetics
SO ANDROLOGY
LA English
DT Article
DE brain morphology; Epigenetics; Klinefelter syndrome; neuropsychology;
testosterone
ID ANDROGEN RECEPTOR GENE; X-CHROMOSOME INACTIVATION; CAG REPEAT
POLYMORPHISM; PERSONALITY-TRAITS; COGNITIVE FUNCTION; CANDIDATE GENES;
OLDER MEN; TESTOSTERONE; PHENOTYPE; ASSOCIATION
AB Klinefelter syndrome (KS, 47,XXY) is associated with increased psychiatric morbidity and cognitive disabilities, although the neuropsychological phenotype shows great variability. Androgen receptor polymorphism (CAG repeat length), skewed X-chromosome inactivation and parent-of-origin of the extra X-chromosome have been suggested to influence cognitive function and psychological traits. These issues have not been clarified for KS patients. We studied X-chromosome inactivation pattern, CAG repeat length and parent-of-origin in relation to educational and cohabitation status, personality and autism traits, psychological distress, cognitive function and brain volumes in 73 KS patients and 73 controls. Grey matter (GM) volume of left insula was significantly decreased in KS patients with skewed X-inactivation (z=5.78) and we observed a borderline significant difference in global brain matter volume where KS patients with skewed X-chromosome inactivation tended to have smaller brains. Skewed X-inactivation, CAG repeat length and parent-of-origin were not correlated with educational and marital status, personality traits, autism traits, and psychological distress, prevalence of depression and anxiety or cognitive function. Interestingly our results regarding brain volumes indicate that X-inactivation has an influence on GM volume in left insula and might also be related to global GM volume, indicating a possible effect of X-linked genes on the development of GM volume in KS patient. Skewed X-inactivation, CAG repeat length and parent-of-origin have no impact on the neuropsychological phenotype in KS (http://www.clinicaltrials.gov (Clinical trial NCT00999310)).
C1 [Skakkebk, A.; Gravholt, C. H.] Aarhus Univ Hosp, Dept Endocrinol & Internal Med MEA, DK-8000 Aarhus C, Denmark.
[Bojesen, A.] Sygehus Lillebaelt, Vejle Hosp, Dept Clin Genet, Vejle, Denmark.
[Kristensen, M. K.] Odense Univ Clin, Dept Mental Hlth, Odense, Denmark.
[Cohen, A.; Hougaard, D. M.] Statens Serum Inst, Dept Clin Biochem Immunol & Genet, Sect Neonatal Screening & Hormones, DK-2300 Copenhagen, Denmark.
[Hertz, J. M.] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark.
[Laurberg, P.] Odense Univ Hosp, Dept Gynecol & Obstet, Fertil Clin, DK-5000 Odense, Denmark.
[Laurberg, P.] Aalborg Univ Hosp, Dept Endocrinol, Aalborg, Denmark.
[Wallentin, M.] Aarhus Univ Hosp, Ctr Functionally Integrat Neurosci, DK-8000 Aarhus, Denmark.
[Wallentin, M.] Aarhus Univ, Ctr Semiot, Aarhus, Denmark.
[Ostergaard, J. R.] Aarhus Univ Hosp, Dept Pediat, Ctr Rare Dis, DK-8000 Aarhus, Denmark.
[Pedersen, A. D.] Vejleford Rehabil Ctr, Stouby, Denmark.
[Pedersen, A. D.] Aarhus Univ, Dept Psychol & Behav Sci, Aarhus, Denmark.
[Gravholt, C. H.] Aarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark.
RP Skakkebk, A (reprint author), Aarhus Univ Hosp, Dept Endocrinol & Internal Med MEA, DK-8000 Aarhus C, Denmark.
EM asj@ki.au.dk
FU Lundbeck Foundation; Augustinus Foundation; Aase and Einar Danielsen
Foundation; University of Aarhus; Novo Nordisk Foundation
FX This study was supported by grants from the Lundbeck Foundation, the
Augustinus Foundation and Aase and Einar Danielsen Foundation. A. S.
received a research fellowship from the University of Aarhus. C. H. G.
was supported by a personal clinical research grant from the Novo
Nordisk Foundation. We would like to thank Eva Schriver, Merete Moller,
Dorte Wulff, Susanne Sorensen, Lone Kvist Dora Zeidler, Michael Geneser
and Kaja Skovgard Jensen for their technical assistance.
CR Aluja A, 2011, PSYCHIAT GENET, V21, P229, DOI 10.1097/YPG.0b013e328345465e
Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
BARTSCH W, 1980, MATURITAS, V2, P109, DOI 10.1016/0378-5122(80)90044-4
Bender BG, 2001, GENET MED, V3, P187, DOI 10.1097/00125817-200105000-00007
Berube NG, 2005, J CLIN INVEST, V115, P258, DOI 10.1172/JCI200522329
Bojesen A, 2011, INT J ANDROL, V34, pE642, DOI 10.1111/j.1365-2605.2011.01223.x
Bojesen A, 2003, J CLIN ENDOCR METAB, V88, P622, DOI 10.1210/jc.2002-021491
Boks MPM, 2007, SCHIZOPHR RES, V93, P399, DOI 10.1016/j.schres.2007.03.015
Boone KB, 2001, J INT NEUROPSYCH SOC, V7, P446, DOI 10.1017/S1355617701744013
Bruining H, 2010, BIOL PSYCHIAT, V68, P1156, DOI 10.1016/j.biopsych.2010.08.034
Bruining H, 2009, PEDIATRICS, V123, pE865, DOI 10.1542/peds.2008-1954
Cohen JD, 2010, J PSYCHIATR RES, V44, P81, DOI 10.1016/j.jpsychires.2009.07.001
Comings DE, 1999, NEUROREPORT, V10, P1589, DOI 10.1097/00001756-199905140-00036
Comings DE, 2000, CLIN GENET, V58, P375, DOI 10.1034/j.1399-0004.2000.580508.x
Geschwind DH, 2000, MENT RETARD DEV D R, V6, P107, DOI 10.1002/1098-2779(2000)6:2<107::AID-MRDD4>3.0.CO;2-2
Hickey T, 2002, J CLIN ENDOCR METAB, V87, P161, DOI 10.1210/jc.87.1.161
Huhtaniemi IT, 2009, J CLIN ENDOCR METAB, V94, P277, DOI 10.1210/jc.2008-0848
Jacobs P, 1989, Prog Clin Biol Res, V311, P135
Jonsson EG, 2001, PSYCHIATR GENET, V11, P19, DOI 10.1097/00041444-200103000-00004
Klein A, 2009, NEUROIMAGE, V46, P786, DOI 10.1016/j.neuroimage.2008.12.037
Klinefelter HF, 1942, J CLIN ENDOCRINOL, V2, P615
Kovacs D, 2009, PSYCHONEUROENDOCRINO, V34, P947, DOI 10.1016/j.psyneuen.2009.01.007
Lanfranco F, 2004, LANCET, V364, P273, DOI 10.1016/S0140-6736(04)16678-6
Lee DM, 2010, EUR J ENDOCRINOL, V162, P1155, DOI 10.1530/EJE-09-0970
Lepage JF, 2013, J NEUROSCI, V33, P8567, DOI 10.1523/JNEUROSCI.5810-12.2013
LORDASANCHEZ I, 1992, HUM GENET, V89, P524
Nagai M, 2007, EUR PSYCHIAT, V22, P387, DOI 10.1016/j.eurpsy.2007.02.006
Nicholls RD, 1998, TRENDS GENET, V14, P194, DOI 10.1016/S0168-9525(98)01432-2
Nielsen J, 1990, Birth Defects Orig Artic Ser, V26, P209
Orstavik KH, 2006, ACTA PAEDIATR, V95, P24, DOI 10.1080/08035320600618783
Plenge RM, 2002, AM J HUM GENET, V71, P168, DOI 10.1086/341123
Prichard ZM, 2007, PSYCHIAT GENET, V17, P299, DOI 10.1097/YPG.0b013e32816ebc9e
Ratcliffe S G, 1990, Birth Defects Orig Artic Ser, V26, P1
Ross JL, 2008, AM J MED GENET A, V146A, P708, DOI 10.1002/ajmg.a.32232
Rubinow DR, 1996, AM J PSYCHIAT, V153, P974
Sankar JS, 2012, GENDER MED, V9, P232, DOI 10.1016/j.genm.2012.05.001
Seidman SN, 2001, BIOL PSYCHIAT, V50, P371, DOI 10.1016/S0006-3223(01)01148-9
Skakkebaek A, 2014, NEUROIMAGE-CLIN, V4, P1, DOI 10.1016/j.nicl.2013.10.013
Skuse DH, 1997, NATURE, V387, P705, DOI 10.1038/42706
Stemkens D, 2006, CLIN GENET, V70, P43, DOI 10.1111/j.1399-0004.2006.00635.x
Talebizadeh Z, 2005, J AUTISM DEV DISORD, V35, P675, DOI 10.1007/s10803-005-0011-z
Tartaglia NR, 2012, J DEV BEHAV PEDIATR, V33, P309, DOI 10.1097/DBP.0b013e31824501c8
Thornton GK, 2009, TRENDS GENET, V25, P501, DOI 10.1016/j.tig.2009.09.011
Thouin MM, 2003, CURR PROTOC HUM GENE, DOI [10.1002/0471142905.hg0907s35., DOI 10.1002/0471142905.HG0907S35]
Tuttelmann F, 2010, MOL HUM REPROD, V16, P386, DOI 10.1093/molehr/gaq019
Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
van Rijn S, 2008, J AUTISM DEV DISORD, V38, P1634, DOI 10.1007/s10803-008-0542-1
Vermeersch H, 2010, EUR J ENDOCRINOL, V163, P319, DOI 10.1530/EJE-10-0090
Westberg L, 2009, J PSYCHIATR NEUROSCI, V34, P205
Wilkinson LS, 2007, NAT REV NEUROSCI, V8, P832, DOI 10.1038/nrn2235
Yaffe K, 2003, BIOL PSYCHIAT, V54, P943, DOI 10.1016/S0006-3223(03)00115-X
Zeger MPD, 2008, J PEDIATR, V152, P716, DOI 10.1016/j.jpeds.2007.10.019
Zitzmann M, 2003, INT J ANDROL, V26, P76, DOI 10.1046/j.1365-2605.2003.00393.x
Zitzmann M, 2004, J CLIN ENDOCR METAB, V89, P6208, DOI 10.1210/jc.2004-1424
NR 55
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD JUL
PY 2014
VL 2
IS 4
BP 632
EP 640
DI 10.1111/j.2047-2927.2014.00229.x
PG 9
WC Andrology
SC Endocrinology & Metabolism
GA AJ9NM
UT WOS:000338038400018
PM 24865607
ER
PT J
AU Prasodjo, A
Pfeiffer, CM
Fazili, Z
Xu, YY
Liddy, S
Yolton, K
Savitz, DA
Lanphear, BP
Braun, JM
AF Prasodjo, Adila
Pfeiffer, Christine M.
Fazili, Zia
Xu, Yingying
Liddy, Stacey
Yolton, Kimberly
Savitz, David A.
Lanphear, Bruce P.
Braun, Joseph M.
TI Serum cotinine and whole blood folate concentrations in pregnancy
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Epidemiology; Folic acid; Pregnancy; Tobacco smoke pollution; Smoking
ID ENVIRONMENTAL TOBACCO-SMOKE; INFANT BIRTH-WEIGHT; PERICONCEPTIONAL
FOLIC-ACID; AUTISM SPECTRUM DISORDERS; TANDEM MASS-SPECTROMETRY;
DIETARY-SUPPLEMENT USE; UNITED-STATES; ELIMINATION KINETICS; TOTAL
HOMOCYSTEINE; MATERNAL SMOKING
AB Purpose: Prenatal tobacco smoke exposure may be associated with low maternal folate levels that increase the risk of adverse infant and child health outcomes by reducing folate availability during fetal development.
Methods: Using data from the Health Outcomes and Measures of the Environment Study, we examined the relationship between secondhand or active tobacco smoke exposure and whole blood folate concentrations in pregnant women from Cincinnati, Ohio (n = 362) at approximately 16-week gestation. We used multivariable linear regression to examine the association between continuous or categorical serum cotinine levels and whole blood folate levels, adjusting for sociodemographic, dietary, and perinatal variables.
Results: After adjustment for potential confounders, an interquartile range increases in serum cotinine concentration (0.012-0.224 ng/mL) was suggestively associated with decreased whole blood folate levels (beta, -23 nmol/L; 95% confidence interval (Cl), -49, 3; P value = .08). Compared with unexposed women, reductions in mean whole blood folate were observed among active smokers (beta, -94, 95% Cl, 195, 6 nmol/L; P value = .40); smaller reductions were observed among women with secondhand exposure (0, 26; Cl. 84, 32 nmol/L; P value = .07).
Conclusions: Consistent with prior studies, active smoking was associated with reduced whole blood folate levels among these pregnant women. Secondhand tobacco smoke exposures were associated with small and imprecise reductions in whole blood folate levels. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Prasodjo, Adila; Savitz, David A.; Braun, Joseph M.] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA.
[Pfeiffer, Christine M.; Fazili, Zia] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Nutr Biomarkers Branch, Atlanta, GA USA.
[Xu, Yingying; Liddy, Stacey; Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA.
[Lanphear, Bruce P.] Simon Fraser Univ, Fac Hlth & Sci, Burnaby, BC V5A 1S6, Canada.
[Lanphear, Bruce P.] BC Childrens & Womens Hosp, Child & Family Res Inst, Vancouver, BC, Canada.
RP Braun, JM (reprint author), Brown Univ, Sch Publ Hlth, Dept Epidemiol, Box G-S121-2, Providence, RI 02912 USA.
EM joseph_braun_1@brown.edu
FU National Institute of Environmental Health Sciences [R00 ES020346, PO1
ES11261, R01 ES020349]
FX This work was supported by National Institute of Environmental Health
Sciences grants R00 ES020346, PO1 ES11261, and R01 ES020349.
CR Adgent MA, 2006, BIRTH DEFECTS RES B, V77, P69, DOI 10.1002/bdrb.20068
Ananth CV, 1999, OBSTET GYNECOL, V93, P622, DOI 10.1016/S0029-7844(98)00408-6
Anderka M, 2010, ACTA OBSTET GYN SCAN, V89, P505, DOI 10.3109/00016341003692261
[Anonymous], 2012, TOBACCO USE TARGETIN
Bailey L. B., 2009, FOLATE HLTH DIS
Beck A. T., 1996, BECK DEPRESSION INVE, V2nd
Benowitz NL, 2009, AM J EPIDEMIOL, V169, P236, DOI 10.1093/aje/kwn301
Berry RJ, 2013, JAMA-J AM MED ASSOC, V309, P611, DOI 10.1001/jama.2013.198
Branum AM, 2013, J NUTR, V143, P486, DOI 10.3945/jn.112.169987
Braun JM, 2010, ENVIRON HEALTH-GLOB, V9, DOI 10.1186/1476-069X-9-53
Braun JM, 2010, PAEDIATR PERINAT EP, V24, P524, DOI 10.1111/j.1365-3016.2010.01146.x
Brough L, 2010, BRIT J NUTR, V104, P437, DOI 10.1017/S0007114510000747
Chen CI, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-359
Cole SR, 2009, INT J EPIDEMIOL, V38, P1674, DOI 10.1093/ije/dyp269
DeLorenze GN, 2002, ENVIRON RES, V90, P21, DOI 10.1006/enrs.2001.4380
Dempsey D, 2000, CLIN PHARMACOL THER, V67, P458, DOI 10.1067/mcp.2000.106129
De-Regil LM, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007950.pub2
DiFranza JR, 2004, PEDIATRICS, V113, P1007
England LJ, 2001, AM J EPIDEMIOL, V153, P954, DOI 10.1093/aje/153.10.954
Eskenazi B, 1999, ENVIRON HEALTH PERSP, V107, P991
Fazili Z, 2004, CLIN CHEM, V50, P2378, DOI 10.1373/clinchem.2004.036541
Fazili Z, 2012, CLIN CHIM ACTA, V413, P966, DOI 10.1016/j.cca.2012.02.003
Fekete K, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-75
Haynes BM, 2013, J NUTR, V143, p1001S
Jaakkola MS, 1997, EUR RESPIR J, V10, P2384, DOI 10.1183/09031936.97.10102384
Jirtle RL, 2007, NAT REV GENET, V8, P253, DOI 10.1038/nrg2045
Julvez J, 2009, PAEDIATR PERINAT EP, V23, P199, DOI 10.1111/j.1365-3016.2009.01032.x
Kalkbrenner AE, 2010, J EXPO SCI ENV EPIDE
Kleinbaum D, 1998, APPL REGRESSION ANAL, V3rd
Leonardi-Bee J, 2008, ARCH DIS CHILD-FETAL, V93, pF351, DOI 10.1136/adc.2007.133553
Li D, 2013, EPIDEMIOLOGY, V24, P921, DOI 10.1097/EDE.0b013e3182a671e4
Ma J, 2000, AM J CLIN NUTR, V71, P774
Mannino DM, 2001, ARCH PEDIAT ADOL MED, V155, P36
McDonald SD, 2002, AM J OBSTET GYNECOL, V187, P620, DOI 10.1067/mob.2002.125239
Oken E, 2008, INT J OBESITY, V32, P201, DOI 10.1038/sj.ijo.0803760
Ozerol E, 2004, FETAL DIAGN THER, V19, P145, DOI 10.1159/000075139
Pagan K, 2001, CLIN CHIM ACTA, V306, P103, DOI 10.1016/S0009-8981(01)00402-8
Pfeiffer CM, 2012, J NUTR, V142, P886, DOI 10.3945/jn.111.156919
Pfeiffer CM, 2004, CLIN CHEM, V50, P423, DOI 10.1373/clinchem.2003.026955
Pfeiffer CM, 2013, J NUTR, V143, p957S, DOI 10.3945/jn.112.173021
PHILLIPS DL, 1989, ARCH ENVIRON CON TOX, V18, P495
Pietrzik K, 2007, AM J CLIN NUTR, V86, P1414
Pirkle JL, 2006, ENVIRON HEALTH PERSP, V114, P853, DOI 10.1289/ehp.8850
Schmidt RJ, 2012, AM J CLIN NUTR, V96, P80, DOI 10.3945/ajcn.110.004416
Shi M, 2007, AM J HUM GENET, V80, P76, DOI 10.1086/510518
Tamura T, 2005, PEDIATRICS, V116, P703, DOI 10.1542/peds.2004-2189
Tong Van T., 2009, Morbidity and Mortality Weekly Report, V58, P1
Ulvik A, 2010, CLIN CHEM, V56, P755, DOI 10.1373/clinchem.2009.137513
United States. Public Health Service. Office of the Surgeon General, 2006, HLTH CONS INV EXP TO
van Wersch JWJ, 2002, EUR J OBSTET GYN R B, V103, P18, DOI 10.1016/S0301-2115(02)00013-1
Wang MJ, 2014, BIOINFORMATICS, V30, P71, DOI 10.1093/bioinformatics/btt603
West AA, 2012, AM J CLIN NUTR, V96, P789, DOI 10.3945/ajcn.112.037523
NR 52
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUL
PY 2014
VL 24
IS 7
BP 498
EP 503
DI 10.1016/j.annepidem.2014.04.004
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AJ7AW
UT WOS:000337850400002
PM 24854185
ER
PT J
AU Burnell, L
Verchere, C
Pugash, D
Loock, C
Robertson, S
Lehman, A
AF Burnell, Lindsay
Verchere, Cynthia
Pugash, Denise
Loock, Christine
Robertson, Sandra
Lehman, Anna
TI Additional post-natal diagnoses following antenatal diagnosis of
isolated cleft lip plus /- palate
SO ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
LA English
DT Article
ID HARD PALATE; ULTRASOUND; ANOMALIES; ABNORMALITIES; FETUSES
AB Introduction Cleft lip with or without palate (CLP) can be diagnosed antenatally through ultrasound, and may be categorised as apparently isolated versus associated with other malformations. Limited data exist on the long-term outcomes following antenatal diagnosis of apparently isolated CLP.
Aim This study examined the long-term post-natal outcomes of CLP when found in isolation antenatally, in order to determine the rates of unexpected additional anomalies, developmental delay or genetic syndromes.
Patients and methods A retrospective chart review of antenatal and post-natal medical charts was completed for a ten-year period between January 2000 and December 2009. At least 2 years of available post-natal clinical information was required for inclusion in the study.
Results A total of 97 cases of antenatally isolated CLP were ascertained. Fifteen pregnancies were terminated. Follow-up data were available for 81 liveborns, though 4 were lost to follow-up prior to 2 years of age. Twelve of the 77 children meeting study criteria were identified to have other major malformations and/or developmental disability either later in the pregnancy or post-natally. Findings included familial clefting syndromes, trisomy 21, autism spectrum disorders, brain malformations, fetal alcohol syndrome and Kabuki syndrome, among other findings. Another 11 children had additional anomalies of minor impact. Examples of findings include a perimembranous ventricular septal defect, mild unilateral optic nerve hypoplasia, mild pulmonary artery stenosis with a small atrial septal defect, and transient delays in fine and gross motor skills. No children with clefting of the lip only had major additional diagnoses.
Conclusions The frequency of an associated complex developmental disorder following an otherwise reassuring fetal ultrasound is around 15%. A few diagnoses could be suspected at the antenatal assessment based on family history or exposures. Our study is lacking comprehensive assessment on the yield of genomic microarray testing for this population.
C1 [Burnell, Lindsay; Lehman, Anna] Univ British Columbia, Dept Med Genet, Vancouver, BC V6H3N1, Canada.
[Burnell, Lindsay; Verchere, Cynthia; Loock, Christine; Robertson, Sandra; Lehman, Anna] British Columbia Childrens Hosp, Vancouver, BC V6H3N1, Canada.
[Verchere, Cynthia; Robertson, Sandra] Univ British Columbia, Dept Surg, Vancouver, BC V6H3N1, Canada.
[Pugash, Denise] Univ British Columbia, Dept Radiol, Vancouver, BC V6H3N1, Canada.
[Pugash, Denise] British Columbia Womens Hosp, Vancouver, BC, Canada.
[Loock, Christine] Univ British Columbia, Dept Pediat, Vancouver, BC V6H3N1, Canada.
RP Lehman, A (reprint author), Univ British Columbia, Dept Med Genet, C234 4500 Oak St, Vancouver, BC V6H3N1, Canada.
EM alehman@cw.bc.ca
CR Baumler M, 2011, ULTRASOUND OBST GYN, V38, P440, DOI 10.1002/uog.8933
Berge SJ, 2001, ULTRASOUND OBST GYN, V18, P422, DOI 10.1046/j.0960-7692.2001.00575.x
Chmait R, 2006, ULTRASOUND OBST GYN, V27, P173, DOI 10.1002/uog.2593
de Milly MN, 2013, PRENATAL DIAG, V33, P273, DOI 10.1002/pd.4058
Gillham JC, 2009, ULTRASOUND OBST GYN, V34, P410, DOI 10.1002/uog.6447
Jones MC, 2000, P GREENW GEN CTR, V19, P122
Maarse W, 2011, ULTRASOUND OBST GYN, V38, P434, DOI 10.1002/uog.8895
Murray JC, 2002, CLIN GENET, V61, P248, DOI 10.1034/j.1399-0004.2002.610402.x
NYBERG DA, 1995, RADIOLOGY, V195, P677
Perrotin F, 2001, EUR J OBSTET GYN R B, V99, P19, DOI 10.1016/S0301-2115(01)00347-5
Shaffer LG, 2012, PRENATAL DIAG, V32, P986, DOI 10.1002/pd.3943
Sommerlad M, 2010, ULTRASOUND OBST GYN, V36, P596, DOI 10.1002/uog.7739
NR 12
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1359-2998
EI 1468-2052
J9 ARCH DIS CHILD-FETAL
JI Arch. Dis. Child.-Fetal Neonatal Ed.
PD JUL
PY 2014
VL 99
IS 4
BP F286
EP F290
DI 10.1136/archdischild-2013-305390
PG 5
WC Pediatrics
SC Pediatrics
GA AJ7XU
UT WOS:000337915600009
PM 24625434
ER
PT J
AU Hezel, DM
McNally, RJ
AF Hezel, Dianne M.
McNally, Richard J.
TI Theory of Mind Impairments in Social Anxiety Disorder
SO BEHAVIOR THERAPY
LA English
DT Article
DE social anxiety disorder; theory of mind; social cognition; anxiety
disorders
ID COMORBIDITY SURVEY REPLICATION; NEGATIVE SELF-IMAGERY; DSM-IV DISORDERS;
COGNITIVE REMEDIATION; MEMORY BIAS; PHOBIA; SCHIZOPHRENIA; EMOTION;
AUTISM; SCALE
AB Social anxiety disorder (SAD) is a common psychiatric disorder characterized by a persistent, excessive fear and avoidance of social and performance situations. Research on cognitive biases indicates individuals with SAD may lack an accurate view of how they are perceived by others, especially in social situations when they allocate important attentional resources to monitoring their own actions as well as external threat. In the present study, we explored whether socially anxious individuals also have impairments in theory of mind (ToM), or the ability to comprehend others' mental states, including emotions, beliefs, and intentions. Forty socially anxious and 40 non-socially-anxious comparison participants completed two ToM tasks: the Reading the Mind in the Eyes and the Movie for the Assessment of Social Cognition. Participants with SAD performed worse on ToM tasks than did non-socially-anxious participants. Relative to comparison participants, those with SAD were more likely to attribute more intense emotions and greater meaning to what others were thinking and feeling. These group differences were not due to interpretation bias. The ToM impairments in people with SAD are in the opposite direction of those in people with autism spectrum conditions whose inferences about the mental states of other people are absent or very limited. This association between SAD and ToM may have important implications for our understanding of both the maintenance and treatment of social anxiety disorder.
C1 [Hezel, Dianne M.; McNally, Richard J.] Harvard Univ, Cambridge, MA 02138 USA.
RP Hezel, DM (reprint author), Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA.
EM dhezel@fas.harvard.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Amir N, 1998, J ABNORM PSYCHOL, V107, P285, DOI 10.1037//0021-843X.107.2.285
Arrais KC, 2010, J PSYCHIATR RES, V44, P535, DOI 10.1016/j.jpsychires.2009.11.003
Baker SL, 2002, BEHAV RES THER, V40, P701, DOI 10.1016/S0005-7967(01)00060-2
Baron-Cohen S, 1997, ADV INFANCY RES, V11, P193
Baron-Cohen S., 2005, UNDERSTANDING OTHER, P3
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Brune M, 2005, SCHIZOPHRENIA BULL, V31, P21, DOI 10.1093/schbul/sbi002
Charman T, 2002, SOC DEV, V11, P1, DOI 10.1111/1467-9507.00183
Constans JI, 1999, BEHAV RES THER, V37, P643, DOI 10.1016/S0005-7967(98)00180-6
Corcoran R., 2000, UNDERSTANDING OTHER, V2, P391
Couture SM, 2006, SCHIZOPHRENIA BULL, V32, pS44, DOI 10.1093/schbul/sb1029
CRAWFORD JR, 1989, BRIT J CLIN PSYCHOL, V28, P267
Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
Eaton W. W., 2004, USE PSYCHOL TESTING, V3, P363
Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
Foa EB, 2000, J ANXIETY DISORD, V14, P501, DOI 10.1016/S0887-6185(00)00036-0
Fresco DM, 2001, PSYCHOL MED, V31, P1025
FRITH U, 1989, BRIT J DISORD COMMUN, V24, P123
GILBERT DT, 1989, J PERS SOC PSYCHOL, V57, P940
Harkness KL, 2005, COGNITION EMOTION, V19, P999, DOI 10.1080/02699930541000110
Hirsch C, 1997, BEHAV RES THER, V35, P1123, DOI 10.1016/S0005-7967(97)00069-7
Hirsch C, 2004, MEMORY, V12, P496, DOI 10.1080/09658210444000106
Hirsch CR, 2004, CLIN PSYCHOL REV, V24, P799, DOI 10.1016/j.cpr.2004.07.005
Hirsch CR, 2000, J ABNORM PSYCHOL, V109, P705, DOI 10.1037//0021-843X.109.4.705
Hope D. A., 1990, J COGNITIVE PSYCHOTH, V4, P185
HOPE DA, 1990, COGNITIVE THER RES, V14, P177, DOI 10.1007/BF01176208
Inoue Y, 2006, J AFFECT DISORDERS, V95, P125, DOI 10.1016/j.jad.2006.04.018
Inoue Y, 2004, J AFFECT DISORDERS, V82, P403, DOI 10.1016/j.jad.2004.04.004
Kashdan TB, 2011, CLIN PSYCHOL REV, V31, P786, DOI 10.1016/j.cpr.2011.03.012
Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
Kim S, 2004, INT J PSYCHOL, V39, P63
Lee L, 2005, J AFFECT DISORDERS, V86, P247, DOI 10.1016/j.jad.2005.02.007
Lysaker PH, 2010, SCHIZOPHR RES, V124, P81, DOI 10.1016/j.schres.2010.06.019
Makkar SR, 2011, BEHAV RES THER, V49, P654, DOI 10.1016/j.brat.2011.07.004
Mathews A, 2005, ANNU REV CLIN PSYCHO, V1, P167, DOI 10.1146/annurev.clinpsy.1.102803.143916
McGurk SR, 2007, AM J PSYCHIAT, V164, P1791, DOI 10.1176/appi.ajp.2007.07060906
Mellings TMB, 2000, BEHAV RES THER, V38, P243, DOI 10.1016/S0005-7967(99)00040-6
Mennin DS, 2002, J ANXIETY DISORD, V16, P661, DOI 10.1016/S0887-6185(02)00134-2
MERCKELBACH H, 1989, BEHAV RES THER, V27, P289, DOI 10.1016/0005-7967(89)90048-X
Niels Christensen P, 2003, Behav Res Ther, V41, P1355, DOI 10.1016/S0005-7967(03)00064-0
Philippot P, 2005, BEHAV RES THER, V43, P639, DOI 10.1016/j.brat.2004.05.005
PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
Rapee RM, 1997, BEHAV RES THER, V35, P741, DOI 10.1016/S0005-7967(97)00022-3
Rytwinski NK, 2009, DEPRESS ANXIETY, V26, P34, DOI 10.1002/da.20503
Sabbagh MA, 2004, BRAIN COGNITION, V55, P209, DOI 10.1016/j.banc.2003.04.002
Samson AC, 2012, J BEHAV THER EXP PSY, V43, P625, DOI 10.1016/j.jbtep.2011.08.007
Seeley-Wait Elizabeth, 2009, Prim Care Companion J Clin Psychiatry, V11, P231, DOI 10.4088/PCC.07m00576
Sharp C., 2001, J AM ACAD CHILD ADOL, V50, P563
Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
Stopa L, 2000, BEHAV RES THER, V38, P273, DOI 10.1016/S0005-7967(99)00043-1
Surcinelli P, 2006, J ANXIETY DISORD, V20, P110, DOI 10.1016/j.janxdis.2004.11.010
Tibi-Elhanany Y, 2011, ISR J PSYCHIATR REL, V48, P98
Vallante M., 2013, COGNITIVE NEUROPSYCH, V18, P326
van den Bos K, 2006, J EXP SOC PSYCHOL, V42, P273, DOI 10.1016/j.jesp.2005.04.003
Voncken MJ, 2003, BEHAV RES THER, V41, P1481, DOI 10.1016/S0005-7967(03)00143-8
Washburn D., 2012, THESIS
Wechsler D., 2008, WECHSLER ADULT INTEL
Wells A, 1999, BEHAV RES THER, V37, P653, DOI 10.1016/S0005-7967(98)00150-8
Wykes T, 2011, AM J PSYCHIAT, V168, P472, DOI 10.1176/appi.ajp.2010.10060855
NR 65
TC 1
Z9 1
PU ASSOC ADV BEHAVIOR THERAPY
PI NEW YORK
PA 305 7TH AVE #16A, NEW YORK, NY 10001-6008 USA
SN 0005-7894
EI 1878-1888
J9 BEHAV THER
JI Behav. Therapy
PD JUL
PY 2014
VL 45
IS 4
BP 530
EP 540
PG 11
WC Psychology, Clinical
SC Psychology
GA AJ7EQ
UT WOS:000337860400007
PM 24912465
ER
PT J
AU Parma, V
Bulgheroni, M
Tirindelli, R
Castiello, U
AF Parma, Valentina
Bulgheroni, Maria
Tirindelli, Roberto
Castiello, Umberto
TI Facilitation of action planning in children with autism: The
contribution of the maternal body odor
SO BRAIN AND COGNITION
LA English
DT Article
DE Action planning; Autism; Automatic imitation; Maternal odor; Visuomotor
priming
ID HIGH-FUNCTIONING AUTISM; MIRROR NEURON SYSTEM; SPECTRUM-DISORDERS;
DEVELOPMENTAL DISORDERS; COGNITIVE NEUROSCIENCE; MOTOR FACILITATION;
SOCIAL-BEHAVIOR; YOUNG-ADULTS; IMITATION; MOVEMENT
AB Imitation is a key socio-cognitive skill impaired in individuals with Autism Spectrum Conditions (ASC). It is known that the familiarity with an actor facilitates the appearance of imitative abilities. Here, we explore whether a highly familiar and socially relevant stimulus presented in the olfactory modality is able to improve spontaneous imitation as early as at the level of action planning. A group of 20 children with ASC and 20 controls observed their own mother or the mother of another child performing a reach-to-grasp action towards an object, under the exposure to their maternal odor, the odor of the mother of another child or no odor. Subsequently, children acted upon the same object with no specific instruction to imitate. Child's movement initiation time (MIT) served as an indicator of motor planning facilitation induced by action observation. Results suggest that for children with ASC (but not controls) MIT was significantly lower when exposed to the maternal odor both when interacting with a familiar or an unfamiliar model. In the former case, the performance is comparable to controls. The familiar model in the absence of any olfactory cue is able to induce a facilitation effect, but the maximal facilitation on MIT is evident when maternal odor and familiar model are paired. We hypothesize that for children with ASC the maternal odor provides relevant social motivation for taking advantage of others' actions when planning movements in an imitative context. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Parma, Valentina; Castiello, Umberto] Univ Padua, Dept Gen Psychol, I-35131 Padua, Italy.
[Bulgheroni, Maria] Ab Acus Srl, I-20155 Milan, Italy.
[Tirindelli, Roberto] Univ Parma, Dept Neurosci, I-43100 Parma, Italy.
RP Parma, V (reprint author), Monell Chem Senses Ctr, Philadelphia, PA 19146 USA.
EM valentina.parma@unipd.it
FU UC from the Ministero dell'Istruzione, dell'Universita e della Ricerca,
Italy
FX This research was supported by a Grant to UC from the Ministero
dell'Istruzione, dell'Universita e della Ricerca, Italy. The funding
source did not have any involvement in the study design, in data
collection, analysis and interpretation, in the writing and
dissemination process. We are especially grateful to the children that
participated in this research and their parents as well as the
colleagues and the students who helped with data gathering. The authors
report no conflict of interest.
CR Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
Aglioti SM, 2011, TRENDS COGN SCI, V15, P47, DOI 10.1016/j.tics.2010.12.003
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Avikainen S, 2003, CURR BIOL, V13, P339, DOI 10.1016/S0960-9822(03)00087-3
Bailenson JN, 2005, PSYCHOL SCI, V16, P814, DOI 10.1111/j.1467-9280.2005.01619.x
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Berardi N, 2000, CURR OPIN NEUROBIOL, V10, P138, DOI 10.1016/S0959-4388(99)00047-1
BERNARDOPITZ V, 1982, J SPEECH HEAR DISORD, V47, P99
Bernier R, 2007, BRAIN COGNITION, V64, P228, DOI 10.1016/j.bandc.2007.03.004
Bird G, 2006, NEUROIMAGE, V31, P1614, DOI 10.1016/j.neuroimage.2006.02.037
Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
Brass M, 2001, NEUROIMAGE, V14, P1416, DOI 10.1006/nimg.2001.0944
Brass M, 2000, BRAIN COGNITION, V44, P124, DOI 10.1006/brcg.2000.1225
Cameron EL, 2013, INT J PEDIATR OTORHI, V77, P346, DOI 10.1016/j.ijporl.2012.11.022
Castiello U, 2002, ATTENTION PERFORM, V19, P315
Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893
Cook J. L, 2011, J AUTISM DEV DISORD, V42, P1045
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Dapretto M, 2006, NAT REV NEUROSCI, V7, P942, DOI DOI 10.1038/NRN2024
Dinstein I, 2010, NEURON, V66, P461, DOI 10.1016/j.neuron.2010.03.034
Donnellan A. M, 2013, FRONT INTEGR NEUROSC, V6, P1
DOTY RL, 1984, PHYSIOL BEHAV, V32, P489, DOI 10.1016/0031-9384(84)90269-5
Edwards MG, 2003, BRAIN COGNITION, V53, P495, DOI 10.1016/S0278-2626(03)00210-0
Frijda NH, 2009, COGNITION EMOTION, V23, P1444, DOI 10.1080/02699930903093276
Fujita S, 2010, HORM BEHAV, V58, P264, DOI 10.1016/j.yhbeh.2010.03.007
Glazebrook C. M., 2007, J AUTISM DEV DISORD, V38, P114
Glazebrook CM, 2006, MOTOR CONTROL, V10, P244
Glazebrook CM, 2009, AUTISM, V13, P411, DOI 10.1177/1362361309105659
Gowen E, 2008, NEUROPSYCHOLOGIA, V46, P1060, DOI 10.1016/j.neuropsychologia.2007.11.004
Hamilton A, 2012, J AUTISM DEV DISORD, V43, P323
Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Harries M. H., 2007, J COGNITIVE NEUROSCI, V3, P9
Heyes C, 2011, PSYCHOL BULL, V137, P463, DOI 10.1037/a0022288
Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8
Hollingshead A. A., 1975, 4 FACTOR INDEX UNPUB
Ingersoll B., 2006, J AUTISM DEV DISORD, V37, P1446
Jacob S, 2001, PHYSIOL BEHAV, V74, P15, DOI 10.1016/S0031-9384(01)00537-6
Jasmin E, 2008, J AUTISM DEV DISORD, V39, P231
KASARI C, 1993, DEV PSYCHOPATHOL, V5, P403, DOI 10.1017/S0954579400004491
Kilner JM, 2006, SOC COGN AFFECT NEUR, V1, P143, DOI 10.1093/scan/nsl017
KNOTT F, 1995, J CHILD PSYCHOL PSYC, V36, P965, DOI 10.1111/j.1469-7610.1995.tb01343.x
Lakatos P, 2009, NEURON, V64, P419, DOI 10.1016/j.neuron.2009.10.014
Lakin JL, 2003, PSYCHOL SCI, V14, P334, DOI 10.1111/1467-9280.14481
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Leary MR, 1996, MENT RETARD, V34, P39
Leighton J, 2008, NEUROPSYCHOLOGIA, V46, P1041, DOI 10.1016/j.neuropsychologia.2007.11.013
Leighton J, 2010, J EXP SOC PSYCHOL, V46, P905, DOI 10.1016/j.jesp.2010.07.001
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lundstrom JN, 2009, HUM BRAIN MAPP, V30, P2571, DOI 10.1002/hbm.20686
Lundstrom JN, 2008, CEREB CORTEX, V18, P1466, DOI 10.1093/cercor/bhm178
Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
Marlier L, 1998, CHILD DEV, V69, P611, DOI 10.1111/j.1467-8624.1998.00611.x
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
Meltzoff AN, 2003, PHILOS T R SOC B, V358, P491, DOI 10.1098/rstb.2002.1261
Molenberghs P, 2009, NEUROSCI BIOBEHAV R, V33, P975, DOI 10.1016/j.neubiorev.2009.03.010
Moriceau S, 2006, J NEUROSCI, V26, P6737, DOI 10.1523/JNEUROSCI.0499-06.2006
Moriceau S, 2006, NAT NEUROSCI, V9, P1004, DOI 10.1038/nn1733
Mujica-Parodi LR, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006415
Nair A, 2013, BRAIN, V136, P1942, DOI 10.1093/brain/awt079
Nazarali N, 2009, J AUTISM DEV DISORD, V39, P1401, DOI 10.1007/s10803-009-0756-x
Nishitani N, 2004, ANN NEUROL, V55, P558, DOI 10.1002/ana.20031
Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Okabe S, 2012, ANIM SCI J, V83, P446, DOI 10.1111/j.1740-0929.2012.01014.x
Parma V, 2013, BIOL PSYCHIAT, V74, P220, DOI 10.1016/j.biopsych.2013.01.010
Partan SR, 2005, AM NAT, V166, P231, DOI 10.1086/431246
Pause BM, 2012, CHEMOSENS PERCEPT, V5, P55, DOI 10.1007/s12078-011-9108-2
Pierno AC, 2008, NEUROPSYCHOLOGIA, V46, P448, DOI 10.1016/j.neuropsychologia.2007.08.020
Pierno AC, 2006, NEUROPSYCHOLOGIA, V44, P1483, DOI 10.1016/j.neuropsychologia.2005.11.013
Porter RH, 1999, GENETICA, V104, P259
Press C, 2010, NEUROPSYCHOLOGIA, V48, P3291, DOI 10.1016/j.neuropsychologia.2010.07.012
Reisenzein R, 2012, GOALS COGNITION ESSA
Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
Rossi S, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001702
Schaal B, 2000, CHEM SENSES, V25, P729, DOI 10.1093/chemse/25.6.729
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
SELTZER B, 1994, J COMP NEUROL, V343, P445, DOI 10.1002/cne.903430308
Spengler S, 2010, BIOL PSYCHIAT, V68, P1148, DOI 10.1016/j.biopsych.2010.09.017
Sridapa C. S., 2014, INT J PHARMACEUT, V16, P255
Sullivan RM, 1998, BIOL NEONATE, V74, P402, DOI 10.1159/000014061
SULLIVAN RM, 1990, DEV BRAIN RES, V53, P243, DOI 10.1016/0165-3806(90)90013-O
Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
Tubaldi F, 2011, SOC NEUROSCI-UK, V6, P31, DOI 10.1080/17470911003691089
van Baaren RB, 2004, PSYCHOL SCI, V15, P71, DOI 10.1111/j.0963-7214.2004.01501012.x
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
Vrticka P., 2012, FRONT HUM NEUROSCI, V6, P1, DOI [10.3389/fnhum.2012.00358, DOI 10.3389/FNHUM.2012.00358]
Wechsler D., 1991, WISC 3 WECHSLER INTE
Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
Yamasue H, 2013, BRAIN DEV-JPN, V35, P111, DOI 10.1016/j.braindev.2012.08.010
Zald DH, 1997, P NATL ACAD SCI USA, V94, P4119, DOI 10.1073/pnas.94.8.4119
Zoia S., 2006, EXP BRAIN RES, V176, P217
NR 97
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0278-2626
EI 1090-2147
J9 BRAIN COGNITION
JI Brain Cogn.
PD JUL
PY 2014
VL 88
BP 73
EP 82
DI 10.1016/j.bandc.2014.05.002
PG 10
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AJ6CQ
UT WOS:000337777700010
PM 24861501
ER
PT J
AU Kadak, MT
Demirel, OF
Yavuz, M
Demir, T
AF Kadak, Muhammed Tayyib
Demirel, Omer Faruk
Yavuz, Mesut
Demir, Turkay
TI Recognition of emotional facial expressions and broad autism phenotype
in parents of children diagnosed with autistic spectrum disorder
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID QUOTIENT AQ; FUNCTIONING AUTISM; FACES; INDIVIDUALS; RELATIVES;
PERSONALITY; INFORMATION; SIBLINGS; FAMILIES
AB Objective: Research findings debate about features of broad autism phenotype. In this study, we tested whether parents of children with autism have problems recognizing emotional facial expression and the contribution of such an impairment to the broad phenotype of autism.
Method: Seventy-two parents of children with autistic spectrum disorder and 38 parents of control group participated in the study. Broad autism features was measured with Autism Quotient (AQ). Recognition of Emotional Face Expression Test was assessed with the Emotion Recognition Test, consisting a set of photographs from Ekman & Friesen's.
Results: In a two-tailed analysis of variance of AQ, there was a significant difference for social skills (F(1, 106) = 6.095; p < .05). Analyses of variance revealed significant difference in the recognition of happy, surprised and neutral expressions (F(1, 106) = 4.068, p = .046; F(1, 106) = 4.068, p = .046; F(1, 106) = 6.064, p = .016).
Conclusion: According to our findings, social impairment could be considered a characteristic feature of BAP. ASD parents had difficulty recognizing neutral expressions, suggesting that ASD parents may have impaired recognition of ambiguous expressions as do autistic children. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Kadak, Muhammed Tayyib; Demir, Turkay] Istanbul Univ, Cerrahpasa Med Sch, Dept Child & Adolescent Psychiat, TR-34100 Istanbul, Turkey.
[Demirel, Omer Faruk] Siverek State Hosp, Dept Psychiat, Sanliurfa, Turkey.
[Yavuz, Mesut] Kanuni State Hosp, Dept Child & Adolescent Psychiat, Istanbul, Turkey.
RP Kadak, MT (reprint author), Istanbul Univ, Cerrahpasa Med Sch, Dept Child & Adolescent Psychiat, TR-34100 Istanbul, Turkey.
EM tayyibkadak@gmail.com
CR Adolphs R, 2008, CURR BIOL, V18, P1090, DOI 10.1016/j.cub.2008.06.073
Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
(APA) APA, 2000, DIAGN STAT MAN MENT
Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Batty M, 2006, DEVELOPMENTAL SCI, V9, P207, DOI 10.1111/j.1467-7687.2006.00480.x
Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
Bolte S, 2003, PSYCHOL MED, V33, P907, DOI 10.1017/S0033291703007438
Bolte S, 2008, J AUTISM DEV DISORD, V38, P776, DOI 10.1007/s10803-007-0443-8
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
Dursun P, 2009, ANATOL J PSYCHIAT, V10, P71
Ekman P., 1976, PICTURES FACIAL AFFE
Gross TF, 2004, J ABNORM CHILD PSYCH, V32, P469, DOI 10.1023/B:JACP.0000037777.17698.01
Grossman RB, 2008, RES AUTISM SPECT DIS, V2, P681, DOI 10.1016/j.rasd.2008.02.004
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020
Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kose S, 2010, ANADOLU PSIKIYATR DE, V11, P253
Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
Lainhart JE, 1999, INT REV PSYCHIATR, V11, P278, DOI 10.1080/09540269974177
Palermo MT, 2006, AUTISM, V10, P353, DOI 10.1177/1362361306064431
Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D
Piven J, 1997, AM J PSYCHIAT, V154, P185
Rutter M, 2000, J ABNORM CHILD PSYCH, V28, P3, DOI 10.1023/A:1005113900068
Scheeren AM, 2008, J AUTISM DEV DISORD, V38, P276, DOI 10.1007/s10803-007-0389-x
Senju A, 2003, COGNITION, V89, P43
Shioiri T, 1999, PSYCHIAT CLIN NEUROS, V53, P45, DOI 10.1046/j.1440-1819.1999.00469.x
Starr E, 2001, J AUTISM DEV DISORD, V31, P89, DOI 10.1023/A:1005669915105
van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055
Wakabayashi A, 2006, J AUTISM DEV DISORD, V36, P263, DOI 10.1007/s10803-005-0061-2
Wallace S, 2010, AUTISM RES, V3, P345, DOI 10.1002/aur.161
Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
Wilson CE, 2010, PLOS ONE, V5
NR 38
TC 1
Z9 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
EI 1532-8384
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD JUL
PY 2014
VL 55
IS 5
BP 1146
EP 1151
DI 10.1016/j.comppsych.2014.03.004
PG 6
WC Psychiatry
SC Psychiatry
GA AJ7AV
UT WOS:000337850300013
PM 24742718
ER
PT J
AU Slane, MM
Lusk, LG
Boomer, KB
Hare, AE
King, MK
Evans, DW
AF Slane, Mylissa M.
Lusk, Laina G.
Boomer, K. B.
Hare, Abby E.
King, Margaret K.
Evans, David W.
TI Social cognition, face processing, and oxytocin receptor single
nucleotide polymorphisms in typically developing children
SO DEVELOPMENTAL COGNITIVE NEUROSCIENCE
LA English
DT Article
DE Social cognition; Oxytocin; Autism spectrum disorder; Typically
developing children; Event-related potential-N170
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; GENE OXTR; SPECTRUM
DISORDERS; MIND; ASSOCIATION; ATTRIBUTION; BEHAVIOR; ADULTS;
SCHIZOPHRENIA
AB Recent research has provided evidence of a link between behavioral measures of social cognition (SC) and neural and genetic correlates. Differences in face processing and variations in the oxytocin receptor (OXTR) gene have been associated with SC deficits and autism spectrum disorder (ASD) traits. Much work has examined the qualitative differences between those with ASD and typically developing (TD) individuals, but very little has been done to quantify the natural variation in ASD-like traits in the typical population. The present study examines this variation in TD children using a multidimensional perspective involving behavior assessment, neural electroencephalogram (EEG) testing, and OXTR genotyping. Children completed a series of neurocognitive assessments, provided saliva samples for sequencing, and completed a face processing task while connected to an EEG. No clear pattern emerged for EEG covariates or genotypes for individual OXTR single nucleotide polymorphisms (SNPs). However, SNPs rs2254298 and rs53576 consistently interacted such that the AG/GG allele combination of these SNPs was associated with poorer performance on neurocognitive measures. These results suggest that neither SNP in isolation is risk-conferring, but rather that the combination of rs2254298(A/G) and rs53576(G/G) confers a deleterious effect on SC across several neurocognitive measures. (C) 2014 Published by Elsevier Ltd.
C1 [Slane, Mylissa M.; Lusk, Laina G.; Evans, David W.] Bucknell Univ, Dept Psychol, Program Neurosci, Lewisburg, PA 17837 USA.
[Boomer, K. B.] Bucknell Univ, Dept Math, Lewisburg, PA 17837 USA.
[Hare, Abby E.; King, Margaret K.] Geisinger Bucknell Autism & Dev Med Ctr, Lewisburg, PA 17837 USA.
RP Evans, DW (reprint author), Geisinger Bucknell Autism & Dev Med Ctr, 120 Hamm Dr,Suite 2, Lewisburg, PA 17837 USA.
EM dwevans@bucknell.edu
FU Bucknell University Graduate Summer Research Stipend
FX This work was supported by a Bucknell University Graduate Summer
Research Stipend.
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Anagnostou E., 2014, BRAIN RES
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Bakermans-Kranenburg MJ, 2008, SOC COGN AFFECT NEUR, V3, P128, DOI 10.1093/scan/nsn004
Bakermans-Kranenburg MJ, 2014, PSYCHIAT GENET, V24, P45, DOI 10.1097/YPG.0b013e3283643684
Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
Bartz JA, 2010, PSYCHOL SCI, V21, P1426, DOI 10.1177/0956797610383439
Beaumont R, 2006, AUTISM, V10, P365, DOI 10.1177/1362361306064416
Bell MD, 2010, SCHIZOPHR RES, V122, P164, DOI 10.1016/j.schres.2010.03.024
Bookheimer S., 2012, INT M AUT RES TOR CA
Brent E, 2004, AUTISM, V8, P283, DOI 10.1177/1362361304045217
BROTHERS L, 1990, MOTIV EMOTION, V14, P81, DOI 10.1007/BF00991637
Campbell DB, 2011, J NEURODEV DISORD, V3, P101, DOI 10.1007/s11689-010-9071-2
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Chan RCK, 2011, RES AUTISM SPECT DIS, V5, P1538, DOI 10.1016/j.rasd.2011.02.017
Chen FS, 2012, SOC PSYCHOL PERS SCI, V3, P93, DOI 10.1177/1948550611410325
Chen FS, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00200
Cheung CHM, 2010, SOC NEUROSCI-UK, V5, P351, DOI 10.1080/17470911003597377
Constantino J. N., 2012, SOCIAL RESPONSIVENES, Vsecond
Constantino JN, 2011, PEDIATR RES, V69, p55R, DOI 10.1203/PDR.0b013e318212ec6e
Costa B, 2009, PSYCHONEUROENDOCRINO, V34, P1506, DOI 10.1016/j.psyneuen.2009.05.006
Frith CD, 2007, CURR BIOL, V17, pR724, DOI 10.1016/j.cub.2007.05.068
Frith CD, 2012, ANNU REV PSYCHOL, V63, P287, DOI 10.1146/annurev-psych-120710-100449
Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
Gordon I, 2013, P NATL ACAD SCI USA, V110, P20953, DOI 10.1073/pnas.1312857110
Guastella AJ, 2008, BIOL PSYCHIAT, V63, P3, DOI 10.1016/j.biopsych.2007.06.026
Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
Herrington JD, 2011, NEUROIMAGE, V56, P2348, DOI 10.1016/j.neuroimage.2011.03.072
Hileman CM, 2011, DEV NEUROPSYCHOL, V36, P214, DOI 10.1080/87565641.2010.549870
Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
Kim HS, 2011, SOC PSYCHOL PERS SCI, V2, P665, DOI 10.1177/1948550611405854
Kim HS, 2010, P NATL ACAD SCI USA, V107, P15717, DOI 10.1073/pnas.1010830107
Klin A, 2006, BRAIN COGNITION, V61, P40, DOI 10.1016/j.bandc.2005.12.016
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
Kogan A, 2011, P NATL ACAD SCI USA, V108, P19189, DOI 10.1073/pnas.1112658108
Krueger F, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00004
Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140
Lucht MJ, 2009, PROG NEURO-PSYCHOPH, V33, P860, DOI 10.1016/j.pnpbp.2009.04.004
McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
Michalska K.J., 2014, FRONT BEHAV NEUROSCI, V3, P1
Montag C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051882
Moreno-De-Luca A, 2013, LANCET NEUROL, V12, P406, DOI 10.1016/S1474-4422(13)70011-5
Park J, 2010, PROG NEURO-PSYCHOPH, V34, P697, DOI 10.1016/j.pnpbp.2010.03.029
Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
Rodrigues SM, 2009, P NATL ACAD SCI USA, V106, P21437, DOI 10.1073/pnas.0909579106
Saphire-Bernstein S, 2011, P NATL ACAD SCI USA, V108, P15118, DOI 10.1073/pnas.1113137108
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Shimoni HN, 2012, PSYCHIAT RES, V197, P85, DOI 10.1016/j.psychres.2012.02.021
Shipley W. C., 2009, SHIPLEY 2 MANUAL
Skuse DH, 2014, P NATL ACAD SCI USA, V111, P1987, DOI 10.1073/pnas.1302985111
Tabak B.A., 2013, SOC COGN AFFECT NEUR
Thompson RJ, 2011, PSYCHONEUROENDOCRINO, V36, P144, DOI 10.1016/j.psyneuen.2010.07.003
Tost H, 2010, P NATL ACAD SCI USA, V107, P13936, DOI 10.1073/pnas.1003296107
Walum H, 2012, BIOL PSYCHIAT, V71, P419, DOI 10.1016/j.biopsych.2011.09.002
Wang JP, 2013, NEUROIMAGE, V81, P199, DOI 10.1016/j.neuroimage.2013.05.029
Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x
Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
NR 64
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1878-9293
EI 1878-9307
J9 DEV COGN NEUROS-NETH
JI Dev. Cogn. Neurosci.
PD JUL
PY 2014
VL 9
BP 160
EP 171
DI 10.1016/j.dcn.2014.04.001
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA AJ8XB
UT WOS:000337990300014
PM 24814480
ER
PT J
AU O'Reilly, K
Peterson, CC
Wellman, HM
AF O'Reilly, Karin
Peterson, Candida C.
Wellman, Henry M.
TI Sarcasm and Advanced Theory of Mind Understanding in Children and Adults
With Prelingual Deafness
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE deafness; theory of mind; sarcasm understanding; second-order false
belief; life span social cognition
ID FALSE-BELIEF; COCHLEAR IMPLANTS; ASPERGER SYNDROME; DISCOURSE IRONY;
NORMAL-HEARING; SIGN-LANGUAGE; AUTISM; COMMUNICATION; CHILDHOOD;
ABILITIES
AB Two studies addressed key theoretical debates in theory of mind (ToM) development by comparing (a) deaf native signers (n = 18), (b) deaf late signers (n = 59), and (c) age-matched hearing persons (n = 74) in childhood (Study 1: n = 81) and adulthood (Study 2: n = 70) on tests of first- and second-order false belief and conversational sarcasm. Results showed ToM development to be a life span phenomenon for deaf and hearing people alike. Native and late signers were outperformed by hearing peers on advanced ToM in childhood (M = 9 years), but in adulthood (M = 40 years), native signers had caught up, whereas late signers had not. Findings highlight the extended importance of conversational interaction for ToM growth.
C1 [O'Reilly, Karin; Peterson, Candida C.] Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
[Wellman, Henry M.] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
RP O'Reilly, K (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
EM candi@psy.uq.edu.au
CR BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Bryant GA, 2005, LANG SPEECH, V48, P257
Carty B., 1990, CROSS CULTURAL COMMU, P233
Courtin C., 1998, PSYCHOL PERSPECTIVES, V2, P79
Creusere MA, 1999, DEV REV, V19, P213, DOI 10.1006/drev.1998.0474
Devine RT, 2013, CHILD DEV, V84, P989, DOI 10.1111/cdev.12017
Dews S, 1996, CHILD DEV, V67, P3071, DOI 10.1111/j.1467-8624.1996.tb01903.x
Edmondson P., 2006, ED PSYCHOL PRACTICE, V22, P159, DOI 10.1080/02667360600720146
Falkman KW, 2007, EUR J DEV PSYCHOL, V4, P178, DOI 10.1080/17405620600574867
Fellinger J, 2005, SOC PSYCH PSYCH EPID, V40, P737, DOI 10.1007/s00127-005-0936-8
Filippova E, 2010, CHILD DEV, V81, P913, DOI 10.1111/j.1467-8624.2010.01442.x
Filippova E, 2008, CHILD DEV, V79, P126, DOI 10.1111/j.1467-8624.2007.01115.x
Gregory S., 1995, DEAF YOUNG PEOPLE TH
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Hughes C, 2000, J CHILD PSYCHOL PSYC, V41, P483, DOI 10.1017/S0021963099005533
Johnston T., 1992, SOCIAL SEMIOTICS, V2, P1, DOI [10.1080/10350339209360346, DOI 10.1080/10350339209360346]
Johnston Trevor, 2007, AUSTR SIGN LANGUAGE, DOI [10.1017/CBO9780511607479, DOI 10.1017/CBO9780511607479]
Ketelaar L, 2012, J PEDIATR PSYCHOL, V37, P1041, DOI 10.1093/jpepsy/jss086
Langdon R, 2004, PSYCHIAT RES, V125, P9, DOI 10.1016/j.psychres.2003.10.005
Marsten A., 1986, CHILD DEV, V57, P461
Meristo M, 2007, DEV PSYCHOL, V43, P1156, DOI 10.1037/0012-1649.43.5.1156
Moeller MP, 2006, CHILD DEV, V77, P751, DOI 10.1111/j.1467-8624.2006.00901.x
Morgan G, 2006, J CHILD PSYCHOL PSYC, V47, P811, DOI 10.1111/j.1469-7610.2006.01621.x
Ong KKL, 2000, BRIT MED J, V320, P967, DOI 10.1136/bmj.320.7240.967
OVERHOLSER JC, 1992, PERS INDIV DIFFER, V13, P799, DOI 10.1016/0191-8869(92)90053-R
PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7
Peterson CC, 2005, CHILD DEV, V76, P502, DOI 10.1111/j.1467-8624.2005.00859.x
Peterson CC, 2009, SCAND J PSYCHOL, V50, P475, DOI 10.1111/j.1467-9450.2009.00750.x
Peterson CC, 2002, CHILD DEV, V73, P1442, DOI 10.1111/1467-8624.00482
Peterson CC, 1999, PSYCHOL SCI, V10, P126, DOI 10.1111/1467-9280.00119
Peterson CC, 2012, CHILD DEV, V83, P469, DOI 10.1111/j.1467-8624.2011.01728.x
Peterson CC, 2000, MIND LANG, V15, P123, DOI 10.1111/1468-0017.00126
Peterson CC, 2004, J CHILD PSYCHOL PSYC, V45, P1096, DOI 10.1111/j.1469-7610.2004.t01-1-00302.x
Preisler G, 2005, AM ANN DEAF, V150, P260, DOI 10.1353/aad.2005.0034
Pyers JE, 2009, PSYCHOL SCI, V20, P805, DOI 10.1111/j.1467-9280.2009.02377.x
Rajendran G, 2005, J AUTISM DEV DISORD, V35, P429, DOI 10.1007/s10803-005-5033-z
Ruffman T, 2002, CHILD DEV, V73, P734, DOI 10.1111/1467-8624.00435
Russell PA, 1998, J CHILD PSYCHOL PSYC, V39, P903, DOI 10.1017/S0021963098002844
Schick B, 2007, CHILD DEV, V78, P376, DOI 10.1111/j.1467-8624.2007.01004.x
Siegal M., 2008, SOCIAL COGNITION DEV, P81, DOI DOI 10.1093/MED/9780198569183
Vaccari C, 1997, J CHILD PSYCHOL PSYC, V38, P793, DOI 10.1111/j.1469-7610.1997.tb01597.x
Van Eldik T, 2005, AM ANN DEAF, V150, P11
van Gent T, 2007, J CHILD PSYCHOL PSYC, V48, P950, DOI 10.1111/j.1469-7610.2007.01775.x
Wanzer M, 1996, COMMUNICATION Q, V44, P42
Wanzer Melissa Bekelja, 2006, COMMUN EDUC, V55, P178, DOI DOI 10.1080/03634520600566132
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Wellman HM, 2013, DEV PSYCHOL, V49, P2357, DOI 10.1037/a0032419
Wellman HM, 2004, CHILD DEV, V75, P523, DOI 10.1111/j.1467-8624.2004.00691.x
Wellman HM, 2011, CHILD DEV, V82, P780, DOI 10.1111/j.1467-8624.2011.01583.x
Wellman HM, 2001, CHILD DEV, V72, P655, DOI 10.1111/1467-8624.00304
Wiig E. H., 1992, CELF P CLIN EVALUATI
WINNER E, 1991, BRIT J DEV PSYCHOL, V9, P257
Woolfe T, 2002, CHILD DEV, V73, P768, DOI 10.1111/1467-8624.00437
NR 53
TC 3
Z9 3
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
EI 1939-0599
J9 DEV PSYCHOL
JI Dev. Psychol.
PD JUL
PY 2014
VL 50
IS 7
BP 1862
EP 1877
DI 10.1037/a0036654
PG 16
WC Psychology, Developmental
SC Psychology
GA AJ8HC
UT WOS:000337942900003
PM 24798505
ER
PT J
AU Chen, YW
Bundy, A
Cordier, R
Einfeld, S
AF Chen, Yu-Wei
Bundy, Anita
Cordier, Reinie
Einfeld, Stewart
TI Feasibility and usability of experience sampling methodology for
capturing everyday experiences of individuals with autism spectrum
disorders
SO DISABILITY AND HEALTH JOURNAL
LA English
DT Article
DE Asperger's syndrome; Ecological momentary assessment; Client-centered
practice; Social experience
ID ECOLOGICAL MOMENTARY ASSESSMENT; HIGH-FUNCTIONING CHILDREN; ASPERGER
SYNDROME; DAILY-LIFE; TIME-USE; ADOLESCENTS; VALIDITY; ADULTS;
SCHIZOPHRENIA; INTERVENTIONS
AB Background: Understanding experiences from the perspective of adults with autism spectrum disorders (ASD), in the myriad of circumstances in which they find themselves every day, is crucial for developing client-centered interventions. However, capturing these experiences can be difficult.
Objective: To investigate the feasibility and usability of experience sampling method (ESM), an ecological momentary assessment, for studying individuals with ASD.
Methods: Four participants (2 males) with Asperger's syndrome or high functioning autism aged 16-32 years carried an iPod touch or iPhone with a pre-installed ESM survey exploring the situation and their perceived internal experiences. Participants were asked to respond to the survey 7 times daily, at random times generated by the device, for 7 days.
Results: A high signal response rate (mean = 71%) and a short average time required for survey completion (mean = 1 min 42 s) supported feasibility of the ESM for use in research with individuals with ASD. Participants reported that the questions were straightforward and that survey completion interfered very little with everyday activities, supporting acceptability of the method. Results of a split-week analysis revealed consistency of experiences; correlations among experiences that are linked logically provided evidence of the internal logic of data gathered using the ESM. Through graphic analysis, we illustrated the usability of ESM for capturing the influence of everyday contexts on internal experiences/perceptions.
Conclusions: The ESM holds promise for examining the impact of social context on the everyday experiences of individuals with ASD. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Chen, Yu-Wei; Bundy, Anita; Einfeld, Stewart] Univ Sydney, Fac Hlth Sci, Lidcombe, NSW 2141, Australia.
[Cordier, Reinie] Curtin Univ, Sch Occupat Therapy & Social Work, Perth, WA 6845, Australia.
[Einfeld, Stewart] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
RP Chen, YW (reprint author), Univ Sydney, Fac Hlth Sci, Lidcombe, NSW 2141, Australia.
EM yu-wei.chen@sydney.edu.au
FU Faculty of Health Sciences, University of Sydney
FX The study was completed by the first author as part of the requirements
for the completion of PhD under supervision of the other authors. The
authors would like to acknowledge the Faculty of Health Sciences,
University of Sydney for the Mary Frances Stephens Scholarship and
Postgraduate Research Support Scheme. The authors also wish to express
their gratitude to the people who participated in the research, Autism
Spectrum Australia (Aspect) and other autism related associations in
Australia for assistance in research advertisement and recruitment.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Barrett LF, 2009, SOCIAL PERSONALITY P, V3, P292, DOI DOI 10.1111/J.1751-9004.2009.00170.X
Barrett LF, 2001, SOC SCI COMPUT REV, V19, P175
Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
Begeer S, 2008, DEV REV, V28, P342, DOI 10.1016/j.dr.2007.09.001
Bouisson J., 2003, J GERONTOL B-PSYCHOL, V5, P280
Bowling A, 2005, J PUBLIC HEALTH-UK, V27, P281, DOI 10.1093/pubmed/fdi031
Bray P, 2010, PHYS OCCUP THER PEDI, V30, P43, DOI 10.3109/01942630903294687
Cappadocia MC, 2011, RES AUTISM SPECT DIS, V5, P70, DOI 10.1016/j.rasd.2010.04.001
Chen Y-W, 2013, DEV NEUROREHABIL, P4
COUGHLIN SS, 1990, J CLIN EPIDEMIOL, V43, P87, DOI 10.1016/0895-4356(90)90060-3
CSIKSZENTMIHALYI M, 1987, J NERV MENT DIS, V175, P526, DOI 10.1097/00005053-198709000-00004
Daniel LS, 2010, FOCUS AUTISM DEV DIS, V25, P220, DOI 10.1177/1088357610378290
Dingfelder HE, 2011, J AUTISM DEV DISORD, V41, P597, DOI 10.1007/s10803-010-1081-0
Granholm E, 2008, SCHIZOPHRENIA BULL, V34, P507, DOI 10.1093/schbul/sbm113
Hektner J.M., 2007, EXPERIENCE SAMPLING
Hintzen A, 2010, PSYCHIAT RES, V179, P75, DOI 10.1016/j.psychres.2010.06.014
HURLBURT RT, 1994, PSYCHOL MED, V24, P385
Jessup G, 2012, MANUAL PIEL SURVEY A
Kasari C, 2010, CURR OPIN NEUROL, V23, P137, DOI 10.1097/WCO.0b013e32833775cd
Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
Kielhofner G, 2005, AM J OCCUP THER, V59, P487
Kimhy D, 2006, J PSYCHIAT RES, V40, P221, DOI 10.1016/j.jpsychires.2005.09.007
Kincaid J.P., 1975, DERIVATION NEW READA
Larson R., 1984, BEING ADOLESCENT CON
LARSON R, 1989, J YOUTH ADOLESCENCE, V18, P511, DOI 10.1007/BF02139071
Lauritsen MB, 2013, EUR CHILD ADOLES PSY, V22, pS37, DOI 10.1007/s00787-012-0359-5
LOCANDER W, 1976, J AM STAT ASSOC, V71, P269, DOI 10.2307/2285297
Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809
Muller E, 2008, AUTISM, V12, P173, DOI 10.1177/1362361307086664
Myin-Germeys I, 2003, ACTA PSYCHIAT SCAND, V107, P124, DOI 10.1034/j.1600-0447.2003.02025.x
Myin-Germeys I, 2009, PSYCHOL MED, V39, P1533, DOI 10.1017/S0033291708004947
Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
Orsmond GI, 2011, AUTISM, V15, P579, DOI 10.1177/1362361310386503
Palmen A, 2012, RES AUTISM SPECT DIS, V6, P602, DOI 10.1016/j.rasd.2011.10.001
Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
Rowntree D, 1991, STAT TEARS
Shiffman S, 2008, ANNU REV CLIN PSYCHO, V4, P1, DOI 10.1146/annurev.clinpsy.3.022806.091415
Simpson RL, 2005, FOCUS AUTISM OTHER D, V20, P140, DOI 10.1177/10883576050200030201
Trull TJ, 2009, PSYCHOL ASSESSMENT, V21, P457, DOI 10.1037/a0017653
Whalen CK, 2002, CHILD DEV, V73, P209, DOI 10.1111/1467-8624.00401
Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0
Woodcock R. W., 2011, WOODCOCK READING MAS
NR 44
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-6574
EI 1876-7583
J9 DISABIL HEALTH J
JI Disabil. Health J.
PD JUL
PY 2014
VL 7
IS 3
BP 361
EP 366
DI 10.1016/j.dhjo.2014.04.004
PG 6
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health; Rehabilitation
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Rehabilitation
GA AJ8UR
UT WOS:000337983800015
PM 24947579
ER
PT J
AU Ruthsatz, J
Ruthsatz, K
Stephens, KR
AF Ruthsatz, Joanne
Ruthsatz, Kyle
Stephens, Kimberly Ruthsatz
TI Putting practice into perspective: Child prodigies as evidence of innate
talent
SO INTELLIGENCE
LA English
DT Article
DE Child prodigy; Intelligence; Working memory; Autism
ID FAMILY-HISTORY; AUTISM; MEMORY; INTELLIGENCE; PERFORMANCE; ABILITIES;
PHENOTYPE; EXPERT
AB The debate over whether exceptional abilities are primarily the product of nature or nurture began centuries ago - and continues to this day. Recently, much of this debate took place within the context of considering the abilities of exceptional musicians. Several of such studies suggested that general intelligence and domain specific skills, both of which fall on the nature side of the spectrum, play a significant role in the development of musical abilities. In this paper, the author demonstrates that those studies which attempted to argue for a purely nurture-driven account of such musical talent, moreover, merely showed that practice has some role to play in the development of talent; they failed to rule out the possibility that factors such as general intelligence and domain specific skills also contribute to the development of exceptional performance abilities. If the evidence generated by studies of exceptional musicians provides a strong basis for believing that nature is the primary driver of exceptional talent, that evidence receives a powerful boost from recent studies of child prodigies. Child prodigies provide a particularly fascinating view on the nature versus nurture debate because of the extremely young age at which the prodigies demonstrate their remarkable abilities, thus, limiting the extent to which their abilities can be solely the result of extreme dedication to practice. Despite this fact, some have still argued that child prodigies' abilities are nurture-driven. Recent research, however, demonstrates that child prodigies' skills are highly dependent on a few features of their cognitive profiles, including elevated general IQs, exceptional working memories, and elevated attention to detail. Other innate characteristics of the child prodigies predict the domain in which the prodigies will excel. Music prodigies, for example, tend to score better with respect to their general IQs, visual spatial abilities, and working memories, than art prodigies. This new research on a group of exceptional - and exceptionally young - performers strongly supports nature as the primary driver of extreme talent. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ruthsatz, Joanne; Ruthsatz, Kyle] Ohio State Univ, Mansfield, OH 44906 USA.
[Stephens, Kimberly Ruthsatz] Brown Univ, Providence, RI 02912 USA.
RP Ruthsatz, J (reprint author), Ohio State Univ, Mansfield, OH 44906 USA.
CR Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bently A., 1966, MUSIC ABILITY CHILDR
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
BOUCHARD TJ, 1981, SCIENCE, V212, P1055, DOI 10.1126/science.7195071
Davidson JW, 1996, BRIT J DEV PSYCHOL, V14, P399
Detterman DK, 1999, J EDUC GIFTED, V22, P148
DIGIAMMARINO M, 1990, J MUSIC THER, V27, P209
ERICSSON KA, 1993, PSYCHOL REV, V100, P363, DOI 10.1037/0033-295X.100.3.363
Ericsson K. A., 1996, ROAD EXCELLENCE ACQU
Feldman D., 2011, CAMBRIDGE HDB INTELL, P210
Feldman D., 1986, NATURES GAMBIT CHILD
Howard RW, 2008, HIGH ABIL STUD, V19, P117, DOI 10.1080/13598130802503991
Howe M. J. A., 1995, PSYCHOL MUSIC, V23, P162, DOI 10.1177/0305735695232004
Howe MJA, 1998, BEHAV BRAIN SCI, V21, P399, DOI 10.1017/S0140525X9800123X
LYNN R, 1989, PERS INDIV DIFFER, V10, P25, DOI 10.1016/0191-8869(89)90173-6
Lynn R., 1986, RES EDUC, V36, P59
McPherson G, 2006, CHILD MUSICIAN HDB M
Piven J, 1997, AM J PSYCHIAT, V154, P185
Ruthsatz J, 2003, INTELLIGENCE, V31, P509, DOI 10.1016/S0160-2896(03)00050-3
Ruthsatz J., COGNITIVE PROF UNPUB
Ruthsatz J, 2008, INTELLIGENCE, V36, P330, DOI 10.1016/j.intell.2007.08.003
Ruthsatz J., 2000, THESIS
Ruthsatz J, 2012, INTELLIGENCE, V40, P419, DOI 10.1016/j.intell.2012.06.002
Shuter R., 1968, PSYCHOL MUSICAL ABIL
SLOBODA JA, 1985, MUSIC PERCEPT, V3, P155
Vandervert LR, 2009, J MIND BEHAV, V30, P15
Winner E, 1996, ROAD TO EXCELLENCE, P271
YOUNG RL, 1995, J AUTISM DEV DISORD, V25, P231, DOI 10.1007/BF02179286
NR 29
TC 3
Z9 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0160-2896
EI 1873-7935
J9 INTELLIGENCE
JI Intelligence
PD JUL-AUG
PY 2014
VL 45
SI SI
BP 60
EP 65
DI 10.1016/j.intell.2013.08.003
PG 6
WC Psychology, Multidisciplinary
SC Psychology
GA AJ6BD
UT WOS:000337773800007
ER
PT J
AU Hallerback, MU
Lugnegard, T
Gillberg, C
AF Hallerback, Maria Unenge
Lugnegard, Tove
Gillberg, Christopher
TI ADHD and Nicotine Use in Schizophrenia or Asperger Syndrome: A
Controlled Study
SO JOURNAL OF ATTENTION DISORDERS
LA English
DT Article
DE ADHD; adult ADHD; comorbidity; Wender-Reimherr Adult Attention Deficit
Disorder Scale
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; EXTENDED-RELEASE
METHYLPHENIDATE; AUTISM SPECTRUM DISORDERS; LOW-PREVALENCE; SUBSTANCE
USE; SYMPTOMS; ADULTS; CHILDREN; SMOKING; DEPENDENCE
AB Objective: To examine ADHD prevalence, rating scales, and relationship to nicotine use in adults with schizophrenia or Asperger syndrome. Method: Ninety-five individuals, 41 with schizophrenia and 54 with Asperger syndrome, were included. Self-rating of adult ADHD symptoms with the Wender-Reimherr Adult Attention Deficit Diagnostic Rating Scale (WRAADDS), parent rating of proband's ADHD childhood and adult life symptoms using the Swanson, Nolan, and Pelham Questionnaire (SNAP), and report of clinical ADHD diagnosis were included as ADHD measures. Nicotine use data were compared with data from a population sample. Results: In all, 10% of the schizophrenia group and 30% of the Asperger syndrome group had a clinical ADHD diagnosis. Nicotine dependency in the whole sample was closely linked to ADHD. Conclusion: The prevalence of comorbid ADHD was high in schizophrenia and Asperger syndrome. The WRAADDS self-rating scale for ADHD can be one useful tool for assessing comorbid ADHD in these patient groups.
C1 [Hallerback, Maria Unenge; Lugnegard, Tove; Gillberg, Christopher] Cent Hosp Karlstad, S-65185 Karlstad, Sweden.
[Hallerback, Maria Unenge; Lugnegard, Tove] Univ Gothenburg, Gothenburg, Sweden.
RP Hallerback, MU (reprint author), Cent Hosp Karlstad, Dept Child & Adolescent Psychiat, S-65185 Karlstad, Sweden.
EM maria.hallerback@liv.se
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Arne M, 2009, SCAND J PRIM HEALTH, V27, P141, DOI 10.1080/02813430902808643
Aubin HJ, 2012, NEUROSCI BIOBEHAV R, V36, P271, DOI 10.1016/j.neubiorev.2011.06.007
Bejerot S, 1999, COMPR PSYCHIAT, V40, P268, DOI 10.1016/S0010-440X(99)90126-8
Bejerot S, 2003, PSYCHIAT RES, V119, P177, DOI 10.1016/S0165-1781(03)00123-9
Berrettini Wade H, 2004, Psychiatry (Edgmont), V1, P12
Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
Charach A, 2011, J AM ACAD CHILD PSY, V50, P9, DOI 10.1016/j.jaac.2010.09.019
de Leon J, 2005, SCHIZOPHR RES, V76, P135, DOI 10.1016/j.schres.2005.02.010
FAGERSTROM KO, 1989, J BEHAV MED, V12, P159, DOI 10.1007/BF00846549
First MB, 2004, COMPREHENSIVE HDB PS, V2
Gehricke JG, 2009, PSYCHOL ADDICT BEHAV, V23, P644, DOI 10.1037/a0017441
George TP, 2009, CAN J PSYCHIAT, V54, P353
GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x
Ginsberg Y, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-112
Hallerback M. U., 2012, PSYCHIAT RES
Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
Keshaven MS, 2003, SCHIZOPHR RES, V59, P85, DOI 10.1016/S0920-9964(01)00400-5
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
Marchant Barrie K, 2011, Atten Defic Hyperact Disord, V3, P237, DOI 10.1007/s12402-011-0054-2
McRae-Clark AL, 2011, J ATTEN DISORD, V15, P539, DOI 10.1177/1087054710371171
Milberger S, 1997, J AM ACAD CHILD PSY, V36, P37, DOI 10.1097/00004583-199701000-00015
Molarius A, 2007, EUR J PUBLIC HEALTH, V17, P125, DOI 10.1093/eurpub/ckl070
Niemi LT, 2003, SCHIZOPHR RES, V60, P239, DOI 10.1016/S0920-9964(02)00234-7
Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
Owen MJ, 2011, BRIT J PSYCHIAT, V198, P173, DOI 10.1192/bjp.bp.110.084384
Peralta V, 2011, SCHIZOPHR RES, V126, P28, DOI 10.1016/j.schres.2010.09.010
Pomerleau C S, 1989, J Subst Abuse, V1, P471
Rapoport JL, 2005, MOL PSYCHIATR, V10, P434, DOI 10.1038/sj.mp.4001642
Reimherr F. W., 2008, WENDER REIMHERR ADUL
Reimherr F. W., 2003, WENDER REIMHERR ADUL
Retz W, 2012, WORLD J BIOL PSYCHIA, V13, P48, DOI 10.3109/15622975.2010.540257
Rosler M, 2009, EUR ARCH PSY CLIN N, V259, P120, DOI 10.1007/s00406-008-0845-4
Rosler M, 2006, EUR ARCH PSY CLIN N, V256, P3, DOI 10.1007/s00406-006-1001-7
Rosler M, 2010, WORLD J BIOL PSYCHIA, V11, P709, DOI 10.3109/15622971003624197
Sibley MH, 2012, J CONSULT CLIN PSYCH, V80, P139, DOI 10.1037/a0026577
Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
Swanson JM, 2001, J AM ACAD CHILD PSY, V40, P168, DOI 10.1097/00004583-200102000-00011
Swendsen J, 2010, ADDICTION, V105, P1117, DOI 10.1111/j.1360-0443.2010.02902.x
Wender PH, 2011, J ATTEN DISORD, V15, P36, DOI 10.1177/1087054709356188
Wender PH, 2001, ANN NY ACAD SCI, V931, P1
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
NR 45
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0547
EI 1557-1246
J9 J ATTEN DISORD
JI J. Atten. Disord.
PD JUL
PY 2014
VL 18
IS 5
BP 425
EP 433
DI 10.1177/1087054712439099
PG 9
WC Psychology, Developmental; Psychiatry
SC Psychology; Psychiatry
GA AJ5GD
UT WOS:000337709800004
PM 22498753
ER
PT J
AU Adamo, N
Di Martino, A
Esu, L
Petkova, E
Johnson, K
Kelly, S
Castellanos, FX
Zuddas, A
AF Adamo, Nicoletta
Di Martino, Adriana
Esu, Lidia
Petkova, Eva
Johnson, Katherine
Kelly, Simon
Castellanos, Francisco Xavier
Zuddas, Alessandro
TI Increased Response-Time Variability Across Different Cognitive Tasks in
Children With ADHD
SO JOURNAL OF ATTENTION DISORDERS
LA English
DT Article
DE ADHD; childhood psychiatric symptoms; cognitive control; neurobiology
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
DEFICIT-HYPERACTIVITY-DISORDER; INTRA-SUBJECT VARIABILITY;
INTRAINDIVIDUAL VARIABILITY; SUSTAINED ATTENTION; ITALIAN CHILDREN;
FLUCTUATIONS; PERFORMANCE; SUBTYPES; AUTISM
AB Objective: Increased response-time (RT) fluctuations below 0.2 Hz have been reported as characteristic of ADHD in some but not all studies, possibly due to methodological differences. Accordingly, We contrasted two tasks and two analytical approaches in the same sample of children with ADHD. Method: Fifty-two children with ADHD and 49 typically developing children completed an Eriksen Flanker Task and a fixed-sequence version of the sustained attention to response task. RT fluctuations with two different frequency analyses were examined. Results: Robust ADHD-related increases of slow RT fluctuations within all frequencies were found in both tasks. Tasks were significantly correlated in both groups for frequencies above 0.07 Hz. RT fluctuations across all frequencies were greatest in children with ADHD with abnormally elevated omissions. Conclusion: We observed significantly increased fluctuations of RT in children with ADHD across two different tasks and methods supporting the hypothesis that slow frequency RT fluctuations reflect neurophysiological processes underlying ADHD.
C1 [Adamo, Nicoletta; Di Martino, Adriana; Castellanos, Francisco Xavier] NYU, Ctr Child Study, Inst Pediat Neurosci, New York, NY 10016 USA.
[Esu, Lidia] Univ Cagliari, Cagliari, Italy.
[Zuddas, Alessandro] Univ Cagliari, Dept Neurosci, Cagliari, Italy.
[Petkova, Eva] NYU, Ctr Child Study, Div Biostat, New York, NY 10016 USA.
[Johnson, Katherine] Univ Melbourne, Melbourne, Vic 3010, Australia.
[Kelly, Simon] CUNY City Coll, Dept Biomed Engn, New York, NY USA.
[Petkova, Eva; Castellanos, Francisco Xavier] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
RP Di Martino, A (reprint author), NYU, Ctr Child Study, Inst Pediat Neurosci, 215 Lexington Ave,14th Floor, New York, NY 10016 USA.
EM Adriana.Dimartino@nyumc.org
RI Di Martino, Adriana/L-2497-2014
FU Leon Levy Foundation; NIMH [K23MH087770]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This work
was supported in part by The Leon Levy Foundation and NIMH (K23MH087770)
awarded to Adriana Di Martino.
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bellgrove MA, 2005, NEUROPSYCHOLOGIA, V43, P1847, DOI 10.1016/j.neuropsychologia.20.05.03.01
Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
Castellanos FX, 2005, BIOL PSYCHIAT, V57, P1416, DOI 10.1016/j.biopsych.2004.12.005
Castellanos FX, 2006, TRENDS COGN SCI, V10, P117, DOI 10.1016/j.tics.2006.01.011
Castellanos FX, 2008, BIOL PSYCHIAT, V63, P332, DOI 10.1016/j.biopsych.2007.06.025
Conners C. K., 1997, CONNERS RATING SCALE
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2005, SOCIAL RESPONSIVENES
Di Martino A, 2008, BIOL PSYCHIAT, V64, P607, DOI 10.1016/j.biopsych.2008.03.008
Fornito A, 2011, J NEUROSCI, V31, P3261, DOI 10.1523/JNEUROSCI.4858-10.2011
Fox MD, 2007, NEURON, V56, P171, DOI 10.1016/j.neuron.2007.08.023
Frigerio A, 2004, EUR J PSYCHOL ASSESS, V20, P124, DOI 10.1027/1015-5759.20.2.124
Geurts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030, DOI 10.1016/j.neuropsychologia.2008.06.013
Grzadzinski R., 2010, J AUTISM DEV DISORD, V41, P1178
Halperin JM, 2008, J CHILD PSYCHOL PSYC, V49, P958, DOI 10.1111/j.1469-7610.2008.01926.x
Helps SK, 2011, NEUROPSYCHOLOGY, V25, P711, DOI 10.1037/a0024479
Hervey AS, 2006, CHILD NEUROPSYCHOL, V12, P125, DOI 10.1080/09297040500499081
Ickowicz A, 2006, CAN J PSYCHIAT, V51, P325
Johnson K. A., 2008, AM J MED GENET B, V147B, P927
Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P630, DOI 10.1016/j.neuropsychologia.2006.03.034
Johnson KA, 2008, NEUROPSYCHOLOGIA, V46, P1532, DOI 10.1016/j.neuropsychologia.2008.01.002
Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019
Kelly AMC, 2008, NEUROIMAGE, V39, P527, DOI 10.1016/j.neuroimage.2007.08.008
Klein C, 2006, BIOL PSYCHIAT, V60, P1088, DOI 10.1016/j.biopsych.2006.04.003
Kuntsi J, 2001, J CHILD PSYCHOL PSYC, V42, P199, DOI 10.1017/S0021963001006709
Leth-Steensen C, 2000, ACTA PSYCHOL, V104, P167, DOI 10.1016/S0001-6918(00)00019-6
Nigg JT, 2002, J AM ACAD CHILD PSY, V41, P59, DOI 10.1097/00004583-200201000-00012
Nigg JT, 2004, J ABNORM PSYCHOL, V113, P614, DOI 10.1037/0021-843X.113.4.614
Nigg JT, 2005, BIOL PSYCHIAT, V57, P1224, DOI 10.1016/j.biopsych.2004.08.025
Nobile M, 2007, CONNERS RATING SCALE
Penttonen Markku, 2003, Thalamus & Related Systems, V2, P145, DOI 10.1016/S1472-9288(03)00007-4
Prado J, 2011, NEUROIMAGE, V54, P541, DOI 10.1016/j.neuroimage.2010.08.022
Reiersen Angela M, 2008, Expert Rev Neurother, V8, P657, DOI 10.1586/14737175.8.4.657
Roid G., 1997, LEITER INT PERFORMAN
Rubia K, 2001, BRIT J PSYCHIAT, V179, P138, DOI 10.1192/bjp.179.2.138
Ruskin DN, 2001, BIOL PSYCHIAT, V49, P340, DOI 10.1016/S0006-3223(00)00987-2
Schachar R., 1996, PARENT INTERVIEW CHI
Scheres A, 2001, J CHILD PSYCHOL PSYC, V42, P347, DOI 10.1111/1469-7610.00728
SHAFFER D, 1983, ARCH GEN PSYCHIAT, V40, P1228
Sonuga-Barke EJS, 2007, NEUROSCI BIOBEHAV R, V31, P977, DOI 10.1016/j.neubiorev.2007.02.005
Vaurio RG, 2009, NEUROPSYCHOLOGIA, V47, P2389, DOI 10.1016/j.neuropsychologia.2009.01.022
Walters J R, 2001, Adv Neurol, V85, P133
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Weissman DH, 2006, NAT NEUROSCI, V9, P971, DOI 10.1038/nn1727
Yordanova J, 2011, BRAIN, V134, P1740, DOI 10.1093/brain/awr107
Zuddas A., 2010, SOCIAL RESPONSIVENES
Zuddas A, 2006, EUR PSYCHIAT, V21, P410, DOI 10.1016/j.eurpsy.2005.08.001
Zuo XN, 2010, NEUROIMAGE, V49, P1432, DOI 10.1016/j.neuroimage.2009.09.037
NR 50
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0547
EI 1557-1246
J9 J ATTEN DISORD
JI J. Atten. Disord.
PD JUL
PY 2014
VL 18
IS 5
BP 434
EP 446
DI 10.1177/1087054712439419
PG 13
WC Psychology, Developmental; Psychiatry
SC Psychology; Psychiatry
GA AJ5GD
UT WOS:000337709800005
PM 22508759
ER
PT J
AU Schaaf, RC
Benevides, T
Mailloux, Z
Faller, P
Hunt, J
van Hooydonk, E
Freeman, R
Leiby, B
Sendecki, J
Kelly, D
AF Schaaf, Roseann C.
Benevides, Teal
Mailloux, Zoe
Faller, Patricia
Hunt, Joanne
van Hooydonk, Elke
Freeman, Regina
Leiby, Benjamin
Sendecki, Jocelyn
Kelly, Donna
TI An Intervention for Sensory Difficulties in Children with Autism: A
Randomized Trial
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Intervention; Sensory functions
ID OCCUPATIONAL-THERAPY; SPECTRUM DISORDERS; MODULATION DISORDER;
YOUNG-CHILDREN; INTEGRATION; FIDELITY; BEHAVIOR; OUTCOMES;
RESPONSIVENESS; ASSOCIATION
AB This study evaluated a manualized intervention for sensory difficulties for children with autism, ages 4-8 years, using a randomized trial design. Diagnosis of autism was confirmed using gold standard measures. Results show that the children in the treatment group (n = 17) who received 30 sessions of the occupational therapy intervention scored significantly higher (p = 0.003, d = 1.2) on Goal Attainment Scales (primary outcome), and also scored significantly better on measures of caregiver assistance in self-care (p = 0.008 d = 0.9) and socialization (p = 0.04, d = 0.7) than the Usual Care control group (n = 15). The study shows high rigor in its measurement of treatment fidelity and use of a manualized protocol, and provides support for the use of this intervention for children with autism. Findings are discussed in terms of their implications for practice and future research.
C1 [Schaaf, Roseann C.] Thomas Jefferson Univ, Fac Farber Inst Neurosci, Dept Occupat Therapy, Philadelphia, PA 19107 USA.
[Benevides, Teal] Jefferson Sch Hlth Profess, Dept Occupat Therapy, Philadelphia, PA 19107 USA.
[Mailloux, Zoe] Pediat Therapy Network, Torrance, CA USA.
[Faller, Patricia; van Hooydonk, Elke; Freeman, Regina] Childrens Specialized Hosp, Toms River, NJ 08755 USA.
[Hunt, Joanne] Childrens Specialized Hosp, Mountainside, NJ 07092 USA.
[Leiby, Benjamin; Sendecki, Jocelyn] Thomas Jefferson Univ, Div Biostat, Philadelphia, PA 19107 USA.
[Kelly, Donna] Childrens Specialized Hosp, New Brunswick, NJ USA.
RP Schaaf, RC (reprint author), Thomas Jefferson Univ, Fac Farber Inst Neurosci, Dept Occupat Therapy, 901 Walnut St,Suite 605, Philadelphia, PA 19107 USA.
EM Roseann.schaaf@jefferson.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
[Anonymous], 2012, PSYCHIAT NEWS
Ashburner J, 2008, AM J OCCUP THER, V62, P564
Ayres A. J., 1989, SENSORY INTEGRATION
Ayres A. J., 1972, SENSORY INTEGRATION
Ayres A. J., 2005, SENSORY INTEGRATION, V25th
Ayres AJ, 1979, SENSORY INTEGRATION
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Bellg AJ, 2004, HEALTH PSYCHOL, V23, P443, DOI 10.1037/0278-6133.23.5.443
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Case-Smith J, 2008, AM J OCCUP THER, V62, P416
Center for Disease Control and Prevention, 2009, MMWR SURVEILL SUMM, V58, pSS
Cohen IL, 2003, J AUTISM DEV DISORD, V33, P31, DOI 10.1023/A:1022226403878
Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
Dunn W., 1999, SENSORY PROFILE
Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
Elliott C., 2007, DIFFERENTIAL ABILITY
Fazlioglu Y, 2008, PERCEPT MOTOR SKILL, V106, P415, DOI 10.2466/PMS.106.2.4t5-422
Goin-Kochel RP, 2009, RES AUTISM SPECT DIS, V3, P528, DOI 10.1016/j.rasd.2008.11.001
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
Haley SM, 1992, PEDIAT EVALUATION DI
Hilton C, 2007, RES AUTISM SPECT DIS, V1, P164, DOI 10.1016/j.rasd.2006.10.002
Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8
Hochhauser M, 2010, RES AUTISM SPECT DIS, V4, P746, DOI 10.1016/j.rasd.2010.01.015
Kiresuk T, 1994, GOAL ATTAINMENT SCAL
KIRESUK TJ, 1968, COMMUNITY MENT HLT J, V4, P443, DOI 10.1007/BF01530764
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Lecavalier L., 2006, J INFORM, V111, P3
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2002, AUTISM DIAGNOSTIC OB
Mailloux Z., 2010, COMPREHENSIVE OCCUPA, P215
Mailloux Z, 2007, AM J OCCUP THER, V61, P254
Mandell D. S., 2005, FREQUENCY CORRELATES
Melnyk B., 2012, INTERVENTION RES
Miller LJ, 2007, AM J OCCUP THER, V61, P228
Miller LJ, 2007, AM J OCCUP THER, V61, P161
Nichols D. S., 1996, PEDIAT PHYS THER, V8, P15
OTTENBACHER KJ, 1990, AM J OCCUP THER, V44, P519
PALISANO RJ, 1992, PHYS THER, V72, P432
Parham D., 2007, AM J OCCUPATIONAL TH, V61, P216
Parham L. D., 2010, OCCUPATIONAL THERAPY, P356
Parham LD, 2011, AM J OCCUP THER, V65, P133, DOI 10.5014/ajot.2011.000745
Patient-Centered Outcomes Research Institute (PCORI), 2013, NAT PRIOR RES RES AG
Pfeiffer BA, 2011, AM J OCCUP THER, V65, P76, DOI 10.5014/ajot.2011.09205
Reynolds S, 2011, J AUTISM DEV DISORD, V41, P1496, DOI 10.1007/s10803-010-1173-x
Roid G. H., 2003, STANFORD BINET INTEL
Ruble L., 2012, J AUTISM DEV DISORD, V42, P1
Ruble LA, 2010, J EARLY INTERVENTION, V32, P286, DOI 10.1177/1053815110382973
Schaaf R. C., 2009, FRAMES REFERENCE PED, P99
Schaaf R. C., BETHESDA AM OC UNPUB
Schaaf R. C., AM J OCCUPATIONAL TH
Schaaf RC, 2015, J AUTISM DEV DISORD, V45, P461, DOI 10.1007/s10803-013-1924-6
Schaaf R. C., 2011, UNPUB
Schaaf RC, 2012, AM J OCCUP THER, V66, P503, DOI 10.5014/ajot.2012.006114
Schaaf RC, 2012, AUTISM, V16, P321, DOI 10.1177/1362361311435157
Schaaf RC, 2011, AUTISM, V15, P373, DOI 10.1177/1362361310386505
Schaaf RC, 2007, AM J OCCUP THER, V61, P239
Schaaf RC, 2012, AM J OCCUP THER, V66, P547, DOI 10.5014/ajot.2012.004473
Schaaf RC, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P245, DOI 10.1007/978-1-4419-6975-0_9
Shonkoff J. P., 2000, NEURONS NEIGHBORHOOD
Smith Roley S., AM J OCCUPATIONAL TH
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stahmer AC, 2011, BRAIN RES, V1380, P229, DOI 10.1016/j.brainres.2010.09.043
Watling R, 1999, AM J OCCUP THER, V53, P498
Watling R, 2011, OCCUPATIONAL THERAPY
Watson LR, 2011, J SPEECH LANG HEAR R, V54, P1562, DOI 10.1044/1092-4388(2011/10-0029)
Weschler D, 2003, WECHSLER INTELLIGENC
Wong VCN, 2010, ALTERN MED REV, V15, P136
NR 69
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1493
EP 1506
DI 10.1007/s10803-013-1983-8
PG 14
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800001
PM 24214165
ER
PT J
AU Pierce, NP
O'Reilly, MF
Sorrells, AM
Fragale, CL
White, PJ
Aguilar, JM
Cole, HA
AF Pierce, Nigel P.
O'Reilly, Mark F.
Sorrells, Audrey M.
Fragale, Christina L.
White, Pamela J.
Aguilar, Jeannie M.
Cole, Heather A.
TI Ethnicity Reporting Practices for Empirical Research in Three
Autism-Related Journals
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Ethnicity; Race; Demographics; Autism spectrum disorder; Reporting
practices
ID SPECTRUM DISORDERS; SPECIAL-EDUCATION; YOUNG-CHILDREN; LANGUAGE
LEARNERS; MOTHERS; HEALTH; ADOLESCENTS; DIAGNOSIS; SERVICES; STRESS
AB This review examines ethnicity reporting in three autism-related journals (Autism, Focus on Autism and Other Developmental Disabilities, and Journal of Autism and Developmental Disorders) over a 6-year period. A comprehensive multistep search of articles is used to identify ethnicity as a demographic variable in these three journals. Articles that identified research participants' ethnicity were further analyzed to determine the impact of ethnicity as a demographic variable on findings of each study. The results indicate that ethnicity has not been adequately reported in these three autism related journals even though previous recommendations have been made to improve inadequacies of descriptive information of research participants in autism research (Kistner and Robbins in J Autism Dev Disord 16:77-82, 1986). Implications for the field of autism spectrum disorders are discussed in addition to further recommendations for future research.
C1 [Pierce, Nigel P.] Univ N Carolina, Chapel Hill, NC USA.
[Pierce, Nigel P.; O'Reilly, Mark F.; Sorrells, Audrey M.; Fragale, Christina L.; White, Pamela J.; Aguilar, Jeannie M.; Cole, Heather A.] Univ Texas Austin, Austin, TX 78712 USA.
[Pierce, Nigel P.] Frank Porter Graham Child Dev Inst, Carrboro, NC 27510 USA.
RP Pierce, NP (reprint author), Frank Porter Graham Child Dev Inst, 517 S Greensboro St, Carrboro, NC 27510 USA.
EM nigel.pierce@utexas.edu
CR Abedi J, 2004, REV EDUC RES, V74, P1, DOI 10.3102/00346543074001001
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Artiles A. J., 1997, LEARNING DISABILITIE, V12, P82
Artiles AJ, 2005, EXCEPT CHILDREN, V71, P283
Beatson J. E., 2002, FOCUS AUTISM OTHER D, V17, P48, DOI 10.1177/108835760201700106
Begeer S, 2009, J AUTISM DEV DISORD, V39, P142, DOI 10.1007/s10803-008-0611-5
Bieberich AA, 2004, J AUTISM DEV DISORD, V34, P439, DOI 10.1023/B:JADD.0000037420.16169.28
Bornman J, 2010, J POLICY PRACT INTEL, V7, P111, DOI 10.1111/j.1741-1130.2010.00254.x
Bos C. S., 1997, LEARNING DISABILITIE, V12, P92
Bryson SA, 2008, AUTISM, V12, P65, DOI 10.1177/1362361307085214
Callahan K, 2008, J AUTISM DEV DISORD, V38, P678, DOI 10.1007/s10803-007-0434-9
Chiang HM, 2008, J INTELL DISABIL RES, V52, P966, DOI 10.1111/j.1365-2788.2008.01042.x
Cohen IL, 2006, J AUTISM DEV DISORD, V36, P1077, DOI 10.1007/s10803-006-0145-7
Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
Dyches TT, 2004, J AUTISM DEV DISORD, V34, P211, DOI 10.1023/B:JADD.0000022611.80478.73
Estrem T. L., 2010, MULTIPLE VOICES ETHN, V12, P5
Fisch GS, 2002, J AUTISM DEV DISORD, V32, P107, DOI 10.1023/A:1014888505185
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1710, DOI 10.1007/s10803-008-0556-8
Ganz JB, 2004, J AUTISM DEV DISORD, V34, P395, DOI 10.1023/B:JADD.0000037416.59095.d7
Hampton E. O., 2002, ASSESSMENT EFFECTIVE, V27, P49, DOI [10.1177/073724770202700406, DOI 10.1177/073724770202700406]
Hilton CL, 2010, J AUTISM DEV DISORD, V40, P633, DOI 10.1007/s10803-009-0905-2
Hoffman C. D., 2006, FOCUS AUTISM OTHER D, V21, P146, DOI [10.1177/10883576060210030301, DOI 10.1177/1088357]
Hoffman CD, 2008, FOCUS AUTISM DEV DIS, V23, P155, DOI 10.1177/1088357608316271
Horowitz CR, 2009, AM J PREV MED, V37, pS195, DOI 10.1016/j.amepre.2009.08.006
Ibanez LV, 2008, AUTISM, V12, P473, DOI 10.1177/1362361308094504
Jarquin VG, 2011, J DEV BEHAV PEDIATR, V32, P179, DOI 10.1097/DBP.0b013e31820b4260
Jegatheesan B, 2010, FOCUS AUTISM DEV DIS, V25, P98, DOI 10.1177/1088357610361344
Kalb LG, 2010, J AUTISM DEV DISORD, V40, P1389, DOI 10.1007/s10803-010-0998-7
Kao B, 2011, J PEDIATR PSYCHOL, V36, P1093, DOI 10.1093/jpepsy/jsr030
KISTNER J, 1986, J AUTISM DEV DISORD, V16, P77, DOI 10.1007/BF01531580
Klingner J. K., 2007, EVIDENCE BASED READI, P223
Lin SS, 2000, EPIDEMIOL REV, V22, P187
Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
Machalicek W, 2008, RES AUTISM SPECT DIS, V2, P395, DOI 10.1016/j.rasd.2007.07.001
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Mandell DS, 2008, J AUTISM DEV DISORD, V38, P1059, DOI 10.1007/s10803-007-0481-2
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
McCray A., 2002, INT J QUALITATIVE ST, V15, P599, DOI [10.1080/0951839022000014330, DOI 10.1080/0951839022000014330]
Morrier M. J., 2008, MULTICULTURAL ED, V16, P31
MORRIS R, 1994, LEARN DISABILITY Q, V17, P106
Murray M. M., 2011, SCH COMMUNITY J, V21, P19
Nissenbaum M. S., 2002, FOCUS AUTISM OTHER D, V17, P30, DOI [10.1177/108835760201700103, DOI 10.1177/108835760201700103]
Overton S., 2002, FOCUS AUTISM OTHER D, V17, P11, DOI [10.1177/108835760201700102, DOI 10.1177/108835760201700102]
Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402
Parette P., 2004, FOCUS AUTISM OTHER D, V19, P114, DOI 10.1177/10883576040190020701
Pugach MC, 2001, EXCEPT CHILDREN, V67, P439
Raad JM, 2008, J PEDIATR PSYCHOL, V33, P688, DOI 10.1093/jpepsy/jsm130
Reed DK, 2013, LEARN DISABILITY Q, V36, P131, DOI 10.1177/0731948712451976
Rivers JW, 2008, J AUTISM DEV DISORD, V38, P1740, DOI 10.1007/s10803-008-0560-z
Rodriguez D., 2009, CHILDHOOD ED, V85, P313
Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1
Ruble LA, 2010, J AUTISM DEV DISORD, V40, P1459, DOI 10.1007/s10803-010-1003-1
Sansosti FJ, 2012, FOCUS AUTISM DEV DIS, V27, P81, DOI 10.1177/1088357612446860
Shanawani H, 2006, J MED ETHICS, V32, P724, DOI 10.1136/jme.2005.014456
Sifers SK, 2002, J PEDIATR PSYCHOL, V27, P19, DOI 10.1093/jpepsy/27.1.19
Simpson R. L., 1992, FOCUS AUTISTIC BEHAV, V7, P1
Skiba R, 2006, TEACH COLL REC, V108, P1424, DOI 10.1111/j.1467-9620.2006.00699.x
Smith LE, 2008, J AUTISM DEV DISORD, V38, P876, DOI 10.1007/s10803-007-0461-6
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
Smith T., 2007, AUTISM SPECTRUM DISO, P1
Sorrells A. M., 2012, J BILINGUAL ED INSTR, V14, P7
Stahmer AC, 2007, ADM POLICY MENT HLTH, V34, P29, DOI 10.1007/s10488-006-0060-4
Stone WL, 2004, J AUTISM DEV DISORD, V34, P691, DOI 10.1007/s10803-004-5289-8
Sullivan AL, 2011, URBAN EDUC, V46, P1526, DOI 10.1177/0042085911416014
Symes W., 2011, J RES SPECIAL ED NEE, V11, P153, DOI 10.1111/j.1471-3802.2011.01196.x
Tek S, 2012, J AUTISM DEV DISORD, V42, P1967, DOI 10.1007/s10803-012-1445-8
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Trembath D, 2005, J INTELLECT DEV DIS, V30, P240, DOI 10.1080/13668250500349458
Twyman J. S., 2008, J EVIDENCE BASED PRA, V9, P86
Vasquez E, 2011, LEARN DISABIL RES PR, V26, P84, DOI 10.1111/j.1540-5826.2011.00328.x
Volker MA, 2010, J AUTISM DEV DISORD, V40, P188, DOI 10.1007/s10803-009-0849-6
Volkmar FR, 2006, CURR OPIN PSYCHIATR, V19, P361, DOI 10.1097/01.yco.0000228754.64743.66
Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
Wallis KE, 2008, ACTA PAEDIATR, V97, P539, DOI 10.1111/j.1651-2227.2008.00720.x
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
Wetherby AM, 2008, AUTISM, V12, P487, DOI 10.1177/1362361308094501
Wilder L. K., 2004, FOCUS AUTISM OTHER D, V19, P105, DOI 10.1177/10883576040190020601
Wing Lorna, 1988, DIAGNOSIS ASSESSMENT, P91
NR 81
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1507
EP 1519
DI 10.1007/s10803-014-2041-x
PG 13
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800002
PM 24488183
ER
PT J
AU Butterworth, TW
Hodge, MAR
Sofronoff, K
Beaumont, R
Gray, KM
Roberts, J
Horstead, SK
Clarke, KS
Howlin, P
Taffe, JR
Einfeld, SL
AF Butterworth, Thomas W.
Hodge, M. Antoinette Redoblado
Sofronoff, Kate
Beaumont, Renae
Gray, Kylie M.
Roberts, Jacqueline
Horstead, Sian K.
Clarke, Kristina S.
Howlin, Patricia
Taffe, John R.
Einfeld, Stewart L.
TI Validation of the Emotion Regulation and Social Skills Questionnaire for
Young People with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ERSSQ; Social skills; Autism Spectrum Disorders; ASD; Validation
ID PERVASIVE DEVELOPMENTAL DISORDERS; RANDOMIZED CONTROLLED-TRIAL;
ASPERGER-SYNDROME; RESPONSIVENESS SCALE; DIAGNOSTIC INTERVIEW; CHILDREN;
INTERVENTION; ADOLESCENTS; MANAGEMENT; BEHAVIOR
AB The current study aims to evaluate the psychometric properties of the Emotion Regulation and Social Skills Questionnaire (ERSSQ), a rating scale designed specifically to assess the social skills of young people with Autism Spectrum Disorder (ASD). The participants were 84 children and young adolescents with ASD, aged between 7.97 and 14.16 years with a mean IQ score of 90.21 (SD = 18.82). The results provide evidence for the concurrent and criterion validity of the ERSSQ Parent form, and the concurrent validity of the ERSSQ Teacher form. The clinical and theoretical implications are discussed, including the necessity of ratings across multiple contexts and the potential use of the ERSSQ in identifying individuals most in need of intervention and for planning and assessing the outcomes of social skills interventions.
C1 [Butterworth, Thomas W.] Univ New S Wales, Sch Psychol, Sydney, NSW, Australia.
[Hodge, M. Antoinette Redoblado] Childrens Hosp Westmead, Child Dev Unit, Westmead, NSW, Australia.
[Sofronoff, Kate; Beaumont, Renae] Univ Queensland, Sch Psychol, Brisbane, Qld, Australia.
[Gray, Kylie M.; Taffe, John R.] Monash Univ, Southern Clin Sch, Dept Psychiat, Ctr Dev Psychiat & Psychol, Clayton, Vic, Australia.
[Roberts, Jacqueline] Griffith Univ, Sch Educ & Profess Studies, Autism Ctr Excellence, Mt Gravatt, Qld 4122, Australia.
[Horstead, Sian K.; Clarke, Kristina S.; Howlin, Patricia; Einfeld, Stewart L.] Univ Sydney, Brain & Mind Res Inst, Camperdown, NSW 2050, Australia.
[Horstead, Sian K.; Clarke, Kristina S.; Howlin, Patricia; Einfeld, Stewart L.] Univ Sydney, Ctr Disabil Res & Policy, Lidcombe, NSW, Australia.
RP Einfeld, SL (reprint author), Univ Sydney, Brain & Mind Res Inst, 94 Mallett St, Camperdown, NSW 2050, Australia.
EM stewart.einfeld@sydney.edu.au
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
(APA) APA, 2000, DIAGN STAT MAN MENT
Australian Bureau of Statistics (ABS), 2008, CENS POP HOUS SOC EC
Bacon AL, 1998, J AUTISM DEV DISORD, V28, P129, DOI 10.1023/A:1026040615628
Barnhill G. P., 2001, J POSIT BEHAV INTERV, V3, P175, DOI 10.1177/109830070100300305
Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Booker K. W., 2011, ASSESSMENT EFFECTIVE, V36, P192
Broderick C, 2002, AUTISM, V6, P427, DOI 10.1177/1362361302006004008
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
Farrugia S., 2006, FOCUS AUTISM OTHER D, V21, P25, DOI DOI 10.1177/10883576060210010401
Gresham F. M., 2008, SOCIAL SKILLS IMPROV
Gresham F. M., 1990, SOCIAL SKILLS RATING
Gresham FM, 2010, PSYCHOL ASSESSMENT, V22, P157, DOI 10.1037/a0018124
Gresham FM, 2011, SCHOOL PSYCHOL QUART, V26, P27, DOI 10.1037/a0022662
Howlin P., 1998, AUTISM PERVASIVE DEV, P209
Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Renk K, 2004, CLIN PSYCHOL REV, V24, P239, DOI 10.1016/j.cpr.2004.01.004
Rutter M., 2003, SOCIAL COMMUNICATION
Sigman M., 1999, MONOGRAPHS SOC RES C, V64, pv, DOI DOI 10.1111/1540-5834.00010
Sofronoff K, 2004, AUTISM, V8, P301, DOI 10.1177/136261304045215
Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
Spence S. H., 2003, CHILD ADOLESCENT MEN, V8, P84, DOI 10.1111/1475-3588.00051
Spence S. H., 1995, SOCIAL SKILLS TRAINI
Tantam D, 2003, CHILD ADOL PSYCH CL, V12, P143, DOI 10.1016/S1056-4993(02)00053-6
Wechsler D, 1999, WECHSLER ABBREVIATED
White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 30
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1535
EP 1545
DI 10.1007/s10803-013-2014-5
PG 11
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800004
PM 24337829
ER
PT J
AU Lyall, K
Ashwood, P
Van de Water, J
Hertz-Picciotto, I
AF Lyall, Kristen
Ashwood, Paul
Van de Water, Judy
Hertz-Picciotto, Irva
TI Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and
Developmental Delay
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autoimmune disease; Asthma; Allergy; Autism; Developmental delay;
Maternal risk factors
ID AUTOIMMUNE-DISEASES; CHILDREN; AUTOANTIBODIES; ANTIBODIES; PREGNANCY;
BEHAVIOR; FAMILY; RISK
AB The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).
C1 [Lyall, Kristen; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Ashwood, Paul; Van de Water, Judy; Hertz-Picciotto, Irva] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
RP Lyall, K (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, Med Sci 1C,One Shields Ave, Davis, CA 95616 USA.
EM kdodge@ucdavis.edu
CR An B. A., 2002, 25827 SAS I INC, V27
Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445
Bandini LG, 2010, J PEDIATR-US, V157, P259, DOI 10.1016/j.jpeds.2010.02.013
Blalock JE, 2007, BRAIN BEHAV IMMUN, V21, P23, DOI 10.1016/j.bbi.2006.09.004
Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
Boyce GC, 1999, J GENET PSYCHOL, V160, P261
Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
Braunschweig D, 2012, ARCH NEUROL-CHICAGO, V69, P693, DOI 10.1001/archneurol.2011.2506
Braunschweig D, 2012, J AUTISM DEV DISORD, V42, P1435, DOI 10.1007/s10803-011-1378-7
Carvalheiras G, 2012, AUTOIMMUN REV, V11, pA520, DOI 10.1016/j.autrev.2011.12.002
Comi A. M., 1999, J CHILD NEUROL, V14, P384
Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Hertzmark E., 2009, SAS MEDIATE MACRO BR
Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
JONES WR, 1994, AUST NZ J OBSTET GYN, V34, P251, DOI 10.1111/j.1479-828X.1994.tb01067.x
Keil A, 2010, EPIDEMIOLOGY, V21, P805, DOI 10.1097/EDE.0b013e3181f26e3f
Kerstjens JM, 2012, DEV MED CHILD NEUROL, V54, P1096, DOI 10.1111/j.1469-8749.2012.04423.x
LAHITA RG, 1988, PSYCHONEUROENDOCRINO, V13, P385, DOI 10.1016/0306-4530(88)90045-5
Lin DY, 1997, STAT MED, V16, P1515, DOI 10.1002/(SICI)1097-0258(19970715)16:13<1515::AID-SIM572>3.3.CO;2-T
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
McAllister D L, 1997, J Int Neuropsychol Soc, V3, P370
MONEY J, 1971, J AUTISM CHILD SCHIZ, V1, P146, DOI 10.1007/BF01537954
Mouridsen SE, 2007, DEV MED CHILD NEUROL, V49, P429
Mullen E, 1995, MULLEN SCALES EARLY
Ross G, 2003, ARCH PEDIAT ADOL MED, V157, P397, DOI 10.1001/archpedi.157.4.397
Rutter M., 2003, SOCIAL COMMUNICATION
Song YW, 2010, QJM-INT J MED, V103, P139, DOI 10.1093/qjmed/hcp165
Sparrow S, 1984, VINELAND ADAPTIVE BE
Sweeten TL, 2003, PEDIATRICS, V112, pE420, DOI 10.1542/peds.112.5.e420
Wootla B, 2011, J AUTOIMMUN, V37, P144, DOI 10.1016/j.jaut.2011.05.007
Zaretsky MV, 2004, OBSTET GYNECOL, V103, P546, DOI 10.1097/01.AOG.0000114980.40445.83
Zimmerman AW, 2007, BRAIN BEHAV IMMUN, V21, P351, DOI 10.1016/j.bbi.2006.08.005
NR 34
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1546
EP 1555
DI 10.1007/s10803-013-2017-2
PG 10
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800005
PM 24337796
ER
PT J
AU Ronconi, L
Facoetti, A
Bulf, H
Franchin, L
Bettoni, R
Valenza, E
AF Ronconi, Luca
Facoetti, Andrea
Bulf, Hermann
Franchin, Laura
Bettoni, Roberta
Valenza, Eloisa
TI Paternal Autistic Traits are Predictive of Infants Visual Attention
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Broader autism phenotype; Spatial attention; Temporal attention;
Frontoparietal network; Right temporoparietal junction; Social brain
development
ID EVENT-RELATED POTENTIALS; SPECTRUM DISORDERS; GENERAL-POPULATION; HUMAN
BRAIN; CHILDREN; PERCEPTION; NETWORKS; MECHANISMS; PHENOTYPE; QUOTIENT
AB Since subthreshold autistic social impairments aggregate in family members, and since attentional dysfunctions appear to be one of the earliest cognitive markers of children with autism, we investigated in the general population the relationship between infants' attentional functioning and the autistic traits measured in their parents. Orienting and alerting attention systems were measured in 8-month-old infants using a spatial cueing paradigm. Results showed that only paternal autistic traits were linked to their children's: (1) attentional disengagement; (2) rapid attentional orienting and (3) alerting. Our findings suggest that an early dysfunction of orienting and alerting systems might alter the developmental trajectory of future ability in social cognition and communication.
C1 [Ronconi, Luca; Facoetti, Andrea; Bettoni, Roberta] Univ Padua, Dept Gen Psychol, Dev & Cognit Neurosci Lab, I-35131 Padua, Italy.
[Facoetti, Andrea] Sci Inst E Medea, Dev Neuropsychol Unit, Bosisio Parini, Italy.
[Bulf, Hermann] Univ Milano Bicocca, Dept Psychol, Milan, Italy.
[Franchin, Laura; Valenza, Eloisa] Univ Padua, Dept Dev & Socializat Psychol, Infant Cognit Lab, I-35131 Padua, Italy.
[Valenza, Eloisa] Univ Padua, Interdept Ctr Cognit Sci CISC, I-35131 Padua, Italy.
[Valenza, Eloisa] Univ Padua, Dipartimento Psicol Sviluppo & Socializzaz, I-35131 Padua, Italy.
RP Valenza, E (reprint author), Univ Padua, Dipartimento Psicol Sviluppo & Socializzaz, Via Venezia 8, I-35131 Padua, Italy.
EM eloisa.valenza@unipd.it
RI Facoetti, Andrea/C-2876-2009
CR Almeida RA, 2010, NEUROPSYCHOLOGIA, V48, P374, DOI 10.1016/j.neuropsychologia.2009.09.024
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
American Psychiatric Association, 1994, TASK FORC DSM IV DSM
Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Bayliss AP, 2011, J AUTISM DEV DISORD, V41, P1573, DOI 10.1007/s10803-010-1159-8
Belmonte MK, 2010, J CHILD PSYCHOL PSYC, V51, P259, DOI 10.1111/j.1469-7610.2009.02153.x
Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
Bruneau N, 2003, INT J PSYCHOPHYSIOL, V51, P17, DOI 10.1016/S0167-8760(03)00149-1
BUTTERWORTH G, 1991, BRIT J DEV PSYCHOL, V9, P55
BUTTERWORTH G, 1990, ATTENTION PERFORM, V8, P605
Callejas A, 2004, BRAIN COGNITION, V54, P225, DOI 10.1016/j.bandc.2004.02.012
Carpenter M., 1998, MONOGR SOC RES CHILD, V63, P1, DOI DOI 10.2307/1166214
Chawarska K, 2013, BIOL PSYCHIAT, V74, P195, DOI 10.1016/j.biopsych.2012.11.022
CIESIELSKI KT, 1990, ELECTROEN CLIN NEURO, V75, P207, DOI 10.1016/0013-4694(90)90174-I
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755
Corbetta M, 2011, ANNU REV NEUROSCI, V34, P569, DOI 10.1146/annurev-neuro-061010-113731
COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
COURCHESNE E, 1985, J AUTISM DEV DISORD, V15, P55, DOI 10.1007/BF01837899
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Dawson G., 1989, AUTISM NATURE DIAGNO, P49
Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103
Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x
Elsabbagh M, 2013, BIOL PSYCHIAT, V74, P189, DOI 10.1016/j.biopsych.2012.11.030
Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
FISCHER B, 1987, NEUROPSYCHOLOGIA, V25, P73, DOI 10.1016/0028-3932(87)90044-3
GOLD MS, 1975, CHILD PSYCHIAT HUM D, V6, P68, DOI 10.1007/BF01438301
Grinter EJ, 2009, J AUTISM DEV DISORD, V39, P1278, DOI 10.1007/s10803-009-0740-5
Hood BM, 1995, ADV INFANCY RES, V10, P163
Hutman T, 2013, BIOL PSYCHIAT, V74, P162, DOI 10.1016/j.biopsych.2013.05.018
Johnson MH, 2011, DEV COGN NEUROS-NETH, V1, P7, DOI 10.1016/j.dcn.2010.07.003
Johnson MH, 1996, J EXP CHILD PSYCHOL, V63, P171, DOI 10.1006/jecp.1996.0046
JOHNSON MH, 1991, J COGNITIVE NEUROSCI, V3, P335, DOI 10.1162/jocn.1991.3.4.335
Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
Karmiloff-Smith A, 1998, TRENDS COGN SCI, V2, P389, DOI 10.1016/S1364-6613(98)01230-3
Keehn B, 2013, NEUROSCI BIOBEHAV R, V37, P164, DOI 10.1016/j.neubiorev.2012.11.014
Keehn B, 2010, J CHILD PSYCHOL PSYC, V51, P1251, DOI 10.1111/j.1469-7610.2010.02257.x
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272
Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
Mann TA, 2003, J CHILD PSYCHOL PSYC, V44, P274, DOI 10.1111/1469-7610.00120
McCleery JP, 2009, BIOL PSYCHIAT, V66, P950, DOI 10.1016/j.biopsych.2009.07.031
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165
Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x
Orekhova EV, 2009, CLIN NEUROPHYSIOL, V120, P520, DOI 10.1016/j.clinph.2008.12.034
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009
Petersen SE, 2012, ANNU REV NEUROSCI, V35, P73, DOI 10.1146/annurev-neuro-062111-150525
POSNER MI, 1990, ANNU REV NEUROSCI, V13, P25, DOI 10.1146/annurev.neuro.13.1.25
POSNER MI, 1980, Q J EXP PSYCHOL, V32, P3, DOI 10.1080/00335558008248231
Richards JE, 2001, DEV COGN NEUROSCI, P321
Richards JE, 2005, DEVELOPMENTAL SCI, V8, P255, DOI 10.1111/j.1467-7687.2005.00414.x
Richards JE, 1997, J EXP PSYCHOL HUMAN, V23, P667, DOI 10.1037/0096-1523.23.3.667
Richards JE, 2003, DEVELOPMENTAL SCI, V6, P312, DOI 10.1111/1467-7687.00287
Ronconi L, 2013, CORTEX, V49, P1025, DOI 10.1016/j.cortex.2012.03.005
Ronconi L, 2014, CEREB CORTEX, V24, P396, DOI 10.1093/cercor/bhs319
Ronconi L, 2013, BRAIN COGNITION, V82, P213, DOI 10.1016/j.bandc.2013.04.006
Ronconi L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049019
Saalmann YB, 2007, SCIENCE, V316, P1612, DOI 10.1126/science.1139140
Sacrey LAR, 2013, BEHAV BRAIN RES, V256, P441, DOI 10.1016/j.bbr.2013.08.028
Sucksmith E, 2011, NEUROPSYCHOL REV, V21, P360, DOI 10.1007/s11065-011-9183-9
Sutherland A, 2010, BRAIN, V133, P2089, DOI 10.1093/brain/awq122
Townsend J, 1996, DEV PSYCHOPATHOL, V8, P563
WAINWRIGHTSHARP JA, 1993, J AUTISM DEV DISORD, V23, P1, DOI 10.1007/BF01066415
Wass S, 2011, CURR BIOL, V21, P1543, DOI 10.1016/j.cub.2011.08.004
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 72
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1556
EP 1564
DI 10.1007/s10803-013-2018-1
PG 9
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800006
PM 24356849
ER
PT J
AU Sun, X
Allison, C
Auyeung, B
Matthews, FE
Norton, S
Baron-Cohen, S
Brayne, C
AF Sun, Xiang
Allison, Carrie
Auyeung, Bonnie
Matthews, Fiona E.
Norton, Samuel
Baron-Cohen, Simon
Brayne, Carol
TI Psychometric Properties of the Mandarin Version of the Childhood Autism
Spectrum Test (CAST): An Exploratory Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum conditions; Categorical data factor analysis; Item
response theory; CAST; China
ID CONFIRMATORY FACTOR-ANALYSIS; ADULT ASPERGER ASSESSMENT; ITEM RESPONSE
THEORY; SCREENING QUESTIONNAIRE; GENERAL-POPULATION; RATING-SCALE;
TRAITS; CHILDREN; ASSOCIATION; VALIDITY
AB Limited studies have investigated the latent autistic traits in the mainland Chinese population for autism spectrum conditions (ASC). This study explored the psychometric properties of a Mandarin Chinese version of the CAST in a sample consisting of 737 children in mainstream schools and 50 autistic cases. A combination of categorical data factor analysis and item response theory suggested a good-fit model of a two-factor solution for 28 items on the Mandarin CAST including social and communication, and inflexible/stereotyped language and behaviours (Goodness-of-fit indices: RMSEA = 0.029, CFI = 0.957, TLI = 0.950, SRMR = 0.064). The correlation between the two factors was moderate (GFC = 0.425). This study provided evidence for the CAST as a multidimensional measure for ASC screening in a Chinese population and also showed that the symptom manifestation of ASC in Chinese children shares similarity with western populations.
C1 [Sun, Xiang; Brayne, Carol] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England.
[Sun, Xiang; Allison, Carrie; Auyeung, Bonnie; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 2AH, England.
[Sun, Xiang] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
[Auyeung, Bonnie] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
[Matthews, Fiona E.] Cambridge Inst Publ Hlth, Biostat Unit, MRC, Cambridge CB2 0SR, England.
[Norton, Samuel] Kings Coll London, Inst Psychiat, Dept Psychol, London SE1 9RT, England.
RP Sun, X (reprint author), Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Forvie Site,Robinson Way, Cambridge CB2 0SR, England.
EM xs227@medschl.cam.ac.uk
CR Allison C, 2008, J AUTISM DEV DISORD, V38, P1414, DOI 10.1007/s10803-007-0509-7
Allison C., 2009, QUANTITATIVE CHECKLI
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Angold A, 2002, J CHILD PSYCHOL PSYC, V43, P1052, DOI 10.1111/1469-7610.00232
Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
Bandalos DL, 2009, STATISTICAL AND METHODOLOGICAL MYTHS AND URBAN LEGENDS: DOCTRINE, VERITY AND FABLE IN THE ORGANIZATIONAL AND SOCIAL SCIENCES, P61
Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
Bartholomew D. J., 2002, ANAL INTERPRETATION
Bolte S, 2011, J AUTISM DEV DISORD, V41, P66, DOI 10.1007/s10803-010-1024-9
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
BROWNE MW, 1992, SOCIOL METHOD RES, V21, P230, DOI 10.1177/0049124192021002005
Conson M, 2011, NEUROCASE, V17, P353, DOI 10.1080/13554794.2010.509325
Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
DeCoster J., 1998, OVERVIEW FACTOR ANAL
Edelen MO, 2007, QUAL LIFE RES, V16, P5, DOI 10.1007/s11136-007-9198-0
Flora DB, 2004, PSYCHOL METHODS, V9, P466, DOI 10.1037/1082-989X.9.4.466
Floyd FJ, 1995, PSYCHOL ASSESSMENT, V7, P286, DOI 10.1037//1040-3590.7.3.286
Frazier TW, 2008, J AUTISM DEV DISORD, V38, P474, DOI 10.1007/s10803-007-0415-z
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Gau SSF, 2011, RES AUTISM SPECT DIS, V5, P809, DOI 10.1016/j.rasd.2010.09.010
Georgiades S, 2007, J AM ACAD CHILD PSY, V46, P188, DOI 10.1097/01.chi.0000242236.90763.7f
Ghaziuddin M, 2010, J AUTISM DEV DISORD, V40, P1146, DOI 10.1007/s10803-010-0969-z
Glanzman M, 2010, J AUTISM DEV DISORD, V40, P266, DOI 10.1007/s10803-009-0819-z
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
James I, 2010, MATH INTELL, V32, P56
Kamio Yoko, 2007, Nihon Rinsho, V65, P477
Kanne S. M., 2011, J AUTISM DEV DISORD, V42, P769
Khalid M. N., 2011, INT J ED PSYCHOL ASS, V8, P69
Kline P., 2000, HDB PYSCHOMETRIC TES
Kuenssberg R, 2011, RES DEV DISABIL, V32, P2183, DOI 10.1016/j.ridd.2011.06.018
Kuenssberg R, 2011, RES DEV DISABIL, V32, P2321, DOI 10.1016/j.ridd.2011.07.034
Lau W. Y., 2012, RES DEV DISABIL, V34, P294
Lecavalier L, 2006, AM J MENT RETARD, V111, P199, DOI 10.1352/0895-8017(2006)111[199:VOTADI]2.0.CO;2
Lecavalier L, 2005, J AUTISM DEV DISORD, V35, P795, DOI 10.1007/s10803-005-0025-6
Lord F. M, 1980, APPL ITEM RESPONSE T
Magyar CI, 2007, J AUTISM DEV DISORD, V37, P1787, DOI 10.1007/s10803-006-0313-9
Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
McCabe H, 2003, RES PRACT PERS SEV D, V28, P16, DOI 10.2511/rpsd.28.1.16
McDonald RP, 1999, TEST THEORY UNIFIED
Muthen B., 1997, PSYCHOMETRI IN PRESS
MUTHEN B, 1989, BRIT J MATH STAT PSY, V42, P55
Muthen L. K., 2010, MPLUS USERS GUIDE VE
Muthen LK, 2009, MPLUS SHORT COURSES
Pandolfi V, 2009, J AUTISM DEV DISORD, V39, P986, DOI 10.1007/s10803-009-0716-5
Posserud B, 2008, AUTISM, V12, P99, DOI 10.1177/1362361307085268
Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x
Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
Sevik AE, 2010, TURK PSIKIYATR DERG, V21, P249
Sharp C, 2006, J ABNORM CHILD PSYCH, V34, P379, DOI 10.1007/s10802-006-9027-x
Shuster J., 2013, J AUTISM DEV DISORD, V44, P90
Snow AV, 2009, J CHILD PSYCHOL PSYC, V50, P734, DOI 10.1111/j.1469-7610.2008.02018.x
Spiker D, 2002, AM J MED GENET, V114, P129, DOI 10.1002/ajmg.10188
Stewart M. E., 2010, PERSONALITY INDIVIDU, V47, P224
Sun X., 2012, RES DEV DISABIL, V34, P469
Sun X., 2012, RES DEV DISABIL, V34, P440
van Lang NDJ, 2006, J CHILD PSYCHOL PSYC, V47, P37, DOI 10.1111/j.1469-7610.2005.01434.x
WHO, 1993, ICD 10 CLASS MENT BE
Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029
Williams J., 2003, SCREENING AUTISM SPE
NR 64
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1565
EP 1576
DI 10.1007/s10803-013-2024-3
PG 12
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800007
PM 24522967
ER
PT J
AU Chiang, HM
Tsai, LY
Cheung, YK
Brown, A
Li, HC
AF Chiang, Hsu-Min
Tsai, Luke Y.
Cheung, Ying Kuen
Brown, Alice
Li, Huacheng
TI A Meta-Analysis of Differences in IQ Profiles Between Individuals with
Asperger's Disorder and High-Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger syndrome; Asperger's disorder; High-functioning autism; IQ;
Cognitive profile; DSM; Meta-analysis; Autistic disorder
ID PERVASIVE DEVELOPMENTAL DISORDERS; COGNITIVE PROFILES; SPECTRUM
DISORDERS; SOCIAL ATTRIBUTION; WAIS-III; CHILDREN; ADULTS; MOTOR;
DISABILITIES; ADOLESCENTS
AB A meta-analysis was performed to examine differences in IQ profiles between individuals with Asperger's disorder (AspD) and high-functioning autism (HFA). Fifty-two studies were included for this study. The results showed that (a) individuals with AspD had significantly higher full-scale IQ, verbal IQ (VIQ), and performance IQ (PIQ) than did individuals with HFA; (b) individuals with AspD had significantly higher VIQ than PIQ; and (c) VIQ was similar to PIQ in individuals with HFA. These findings seem to suggest that AspD and HFA are two different subtypes of Autism. The implications of the present findings to DSM-5 Autism Spectrum Disorder are discussed.
C1 [Chiang, Hsu-Min; Brown, Alice] Columbia Univ, Dept Hlth & Behav Studies, Teachers Coll, New York, NY 10027 USA.
[Chiang, Hsu-Min] Columbia Univ, Intellectual Disabil Autism Program, Teachers Coll, New York, NY 10027 USA.
[Tsai, Luke Y.] Univ Michigan, Sch Med, Ann Arbor, MI USA.
[Cheung, Ying Kuen] Columbia Univ, Dept Biostat, Sch Publ Hlth, New York, NY 10027 USA.
[Li, Huacheng] Columbia Univ, Dept Human Dev, Teachers Coll, Measurement Evaluat & Stat Program, New York, NY 10027 USA.
RP Chiang, HM (reprint author), Columbia Univ, Intellectual Disabil Autism Program, Teachers Coll, 525 West 120th St,Box 223, New York, NY 10027 USA.
EM hchiang@tc.columbia.edu
CR American Psychiatric Association, 2000, DIAG STAT MAN MENT D
BARTAK L, 1976, J AUTISM CHILD SCHIZ, V6, P109, DOI 10.1007/BF01538054
Borenstein M., 2005, COMPREHENSIVE METAAN
Chan RCK, 2011, RES AUTISM SPECT DIS, V5, P1538, DOI 10.1016/j.rasd.2011.02.017
Dahlgren SO, 1996, J CHILD PSYCHOL PSYC, V37, P759, DOI 10.1111/j.1469-7610.1996.tb01469.x
DEMYER MK, 1975, J AUTISM CHILD SCHIZ, V5, P109, DOI 10.1007/BF01537928
DEMYER MK, 1974, J AUTISM CHILD SCHIZ, V4, P42, DOI 10.1007/BF02104999
Ehlers S, 1997, J CHILD PSYCHOL PSYC, V38, P207, DOI 10.1111/j.1469-7610.1997.tb01855.x
Enticott PG, 2009, DEV MED CHILD NEUROL, V51, P787, DOI 10.1111/j.1469-8749.2009.03270.x
FINE J, 1994, J AUTISM DEV DISORD, V24, P315, DOI 10.1007/BF02172230
Fiorello CA, 2001, LEARN INDIVID DIFFER, V13, P115, DOI 10.1016/S1041-6080(02)00075-4
Foley-Nicpon M, 2012, GIFTED CHILD QUART, V56, P77, DOI 10.1177/0016986211433199
Ghaziuddin M, 2005, J AUTISM DEV DISORD, V35, P177, DOI 10.1007/s10803-005-1996-z
Ghaziuddin M, 1995, J INTELL DISABIL RES, V39, P538
Ghaziuddin M, 2004, J AUTISM DEV DISORD, V34, P279, DOI 10.1023/B:JADD.0000029550.19098.77
Gilchrist A, 2001, J CHILD PSYCHOL PSYC, V42, P227, DOI 10.1017/S0021963001006631
GILLBERG C, 1987, DEV MED CHILD NEUROL, V29, P641
Gras-Vincendon A, 2007, AUTISM, V11, P523, DOI 10.1177/1362361307083257
Holdnack J, 2011, ASSESSMENT, V18, P192, DOI 10.1177/1073191110394771
Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
Iwanaga R, 2000, J AUTISM DEV DISORD, V30, P169, DOI 10.1023/A:1005467807937
Jolliffe T, 2000, PSYCHOL MED, V30, P1169, DOI 10.1017/S003329179900241X
Jou RJ, 2010, J CHILD NEUROL, V25, P1462, DOI 10.1177/0883073810368311
Kamio Y, 2007, J AUTISM DEV DISORD, V37, P867, DOI 10.1007/s10803-006-0214-y
Kanai C, 2012, RES AUTISM SPECT DIS, V6, P58, DOI 10.1016/j.rasd.2011.09.004
Kaufman A. S., 1994, INTELLIGENT TESTING
Kenworthy LE, 2005, DEV NEUROPSYCHOL, V28, P809, DOI 10.1207/s15326942dn2803_4
KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
Koyama T, 2007, PSYCHIAT CLIN NEUROS, V61, P99, DOI 10.1111/j.1440-1819.2007.01617.x
LINCOLN AJ, 1988, J AUTISM DEV DISORD, V18, P505, DOI 10.1007/BF02211870
Lotspeich L, 2004, ARCH GEN PSYCHIAT, V61, P291, DOI 10.1001/archpsyc.61.3.291
Macintosh K, 2006, J AUTISM DEV DISORD, V36, P1065, DOI 10.1007/s10803-006-0139-5
MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
May T, 2011, J AUTISM DEV DISORD, V41, P837, DOI 10.1007/s10803-010-1101-0
Mazefsky CA, 2007, J AUTISM DEV DISORD, V37, P1086, DOI 10.1007/s10803-006-0251-6
Miller JN, 2000, J ABNORM PSYCHOL, V109, P227, DOI 10.1037/0021-843X.109.2.227
Muller E, 2006, J AUTISM DEV DISORD, V36, P1089, DOI 10.1007/s10803-006-0146-6
Nihei Setsuko, 2008, Tohoku Psychologica Folia, V67, P6
Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
Noterdaeme M, 2010, EUR CHILD ADOLES PSY, V19, P475, DOI 10.1007/s00787-009-0057-0
Ozonoff S., 2000, AUTISM, V4, P29, DOI DOI 10.1177/1362361300041003
Papadopoulos N, 2012, RES AUTISM SPECT DIS, V6, P286, DOI 10.1016/j.rasd.2011.05.010
Papadopoulos N, 2012, AUTISM, V16, P627, DOI 10.1177/1362361311418692
Pijnacker J, 2009, J AUTISM DEV DISORD, V39, P607, DOI 10.1007/s10803-008-0661-8
Planche P, 2012, RES AUTISM SPECT DIS, V6, P939, DOI 10.1016/j.rasd.2011.12.009
Prifitera A., 2005, WISC 4 CLIN USE INTE
Ray-Subramanian CE, 2011, J AUTISM DEV DISORD, V41, P679, DOI 10.1007/s10803-010-1083-y
Rinehart NJ, 2008, AUTISM, V12, P249, DOI 10.1177/1362361307088754
Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
Sahyoun CP, 2009, J AUTISM DEV DISORD, V39, P1014, DOI 10.1007/s10803-009-0712-9
Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6
Scott JA, 2009, AUTISM RES, V2, P246, DOI 10.1002/aur.97
Seung HK, 2007, CLIN LINGUIST PHONET, V21, P247, DOI 10.1080/02699200701195081
Siegel DJ, 1996, J AUTISM DEV DISORD, V26, P389, DOI 10.1007/BF02172825
SIMON EW, 1995, J INTELL DISABIL RES, V39, P326
South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3
Speirs S, 2011, AUTISM, V15, P307, DOI 10.1177/1362361310386501
Spek AA, 2010, J AUTISM DEV DISORD, V40, P280, DOI 10.1007/s10803-009-0860-y
Spek AA, 2008, J AUTISM DEV DISORD, V38, P782, DOI 10.1007/s10803-007-0446-5
Spek AA, 2011, J AUTISM DEV DISORD, V41, P859, DOI 10.1007/s10803-010-1106-8
Stanley-Cary C, 2011, CEREBELLUM, V10, P70, DOI 10.1007/s12311-010-0229-y
Starr E, 2003, J AUTISM DEV DISORD, V33, P15, DOI 10.1023/A:1022222202970
Szatmari P, 2009, J CHILD PSYCHOL PSYC, V50, P1459, DOI 10.1111/j.1469-7610.2009.02123.x
Tsermentseli S, 2008, J AUTISM DEV DISORD, V38, P1201, DOI 10.1007/s10803-007-0500-3
Verte S, 2006, AUTISM, V10, P266, DOI 10.1177/1362361306063299
Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5
Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
Williams DL, 2008, RES AUTISM SPECT DIS, V2, P353, DOI 10.1016/j.rasd.2007.08.005
NR 70
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1577
EP 1596
DI 10.1007/s10803-013-2025-2
PG 20
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800008
PM 24362849
ER
PT J
AU Jimenez, L
Lorda, MJ
Mendez, C
AF Jimenez, Luis
Jose Lorda, Maria
Mendez, Castor
TI Emulation and Mimicry in School Students with Typical Development and
with High Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Imitation; Mimicry; Emulation; Automatic imitation; Overimitation
ID SPECTRUM DISORDER; IMITATION; CHILDREN; COMPATIBILITY; HYPOTHESIS;
RESPONSES; QUOTIENT; VERSION; MOTOR; TASK
AB Two samples of participants with typical development (TD) and high functioning autism performed an imitation task where the goal was of high or low salience, and where the modeled action complied with or was contrary to the end-state comfort (ESC) effect. Imitation was affected by the ESC effect in both groups, and participants with autism reproduced high salient goals as frequently as did participants with TD, but they reproduced less of the low salient goals. Participants with autism showed a reduced tendency to reproduce those actions which were relatively inefficient to reach the goals. The results are discussed in terms of either a relative imbalance between emulation and mimicry in autism, or a reduced tendency to overimitate.
C1 [Jimenez, Luis; Jose Lorda, Maria; Mendez, Castor] Univ Santiago de Compostela, Fac Psicol, Santiago De Compostela 15782, Spain.
[Jose Lorda, Maria] Adapta Consultores, Santiago De Compostela 15705, Spain.
RP Jimenez, L (reprint author), Univ Santiago de Compostela, Fac Psicol, Santiago De Compostela 15782, Spain.
EM luis.jimenez@usc.es; marialordasanchez@gmail.com; castor.mendez@usc.es
RI Jimenez, Luis/C-6050-2011
OI Jimenez, Luis/0000-0002-0763-4220
CR Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
Cook JL, 2012, J AUTISM DEV DISORD, V42, P1045, DOI 10.1007/s10803-011-1341-7
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Giganti F., 2009, CURRENT PSYCHOL LETT, V25
Hamilton A. F., 2007, ATTENTION PERFORMANC, V22
Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
Hamilton AFDC, 2008, Q J EXP PSYCHOL, V61, P101, DOI 10.1080/17470210701508798
Helt MS, 2010, CHILD DEV, V81, P1620, DOI 10.1111/j.1467-8624.2010.01495.x
Heyes C, 2011, PSYCHOL BULL, V137, P463, DOI 10.1037/a0022288
Hobson J. A., 2006, IMITATION SOCIAL MIN, P198
Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481
Horner V, 2005, ANIM COGN, V8, P164, DOI 10.1007/s10071-004-0239-6
Hughes C, 1996, J AUTISM DEV DISORD, V26, P99, DOI 10.1007/BF02276237
Jimenez L, 2012, ACTA PSYCHOL, V141, P96, DOI 10.1016/j.actpsy.2012.07.007
Jimenez L., AUTOMATIC IMIT UNPUB
Magnee MJCM, 2007, J CHILD PSYCHOL PSYC, V48, P1122, DOI 10.1111/j.1469-7610.2007.01779.x
Marsh L, 2013, CURR BIOL, V23, pR266, DOI 10.1016/j.cub.2013.02.036
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
Nielsen M, 2013, AUTISM RES, V6, P23, DOI 10.1002/aur.1261
Nielsen M, 2006, DEV PSYCHOL, V42, P555, DOI 10.1037/0012-1649.42.3.555
Press C, 2010, NEUROPSYCHOLOGIA, V48, P3291, DOI 10.1016/j.neuropsychologia.2010.07.012
Proctor RW, 2003, Q J EXP PSYCHOL-A, V56, P309, DOI 10.1080/02724980244000350
Raven J., 2003, MANUAL RAVENS PROGRE
Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
Rogers S. J., 2006, IMITATION SOCIAL MIN, P277
Rogers SJ, 2010, DEV PSYCHOPATHOL, V22, P71, DOI 10.1017/S0954579409990277
ROSENBAUM DA, 1990, ATTENTION PERFORM, V8, P321
Senju A, 2007, BIOLOGY LETT, V3, P706, DOI 10.1098/rsbl.2007.0337
Senju A, 2013, BRAIN DEV-JPN, V35, P96, DOI 10.1016/j.braindev.2012.08.002
Spengler S, 2010, BIOL PSYCHIAT, V68, P1148, DOI 10.1016/j.biopsych.2010.09.017
Thibaut JP, 2010, J EXP CHILD PSYCHOL, V105, P116, DOI 10.1016/j.jecp.2009.10.003
TOMASELLO M, 1993, BEHAV BRAIN SCI, V16, P495
van Swieten LM, 2010, J EXP PSYCHOL HUMAN, V36, P493, DOI 10.1037/a0017177
Vivanti G, 2008, J EXP CHILD PSYCHOL, V101, P186, DOI 10.1016/j.jecp.2008.04.008
Want SC, 2002, DEVELOPMENTAL SCI, V5, P1, DOI 10.1111/1467-7687.00194
Weigelt M, 2010, EXP PSYCHOL, V57, P476, DOI 10.1027/1618-3169/a000059
WHITEN A, 1992, ADV STUD BEHAV, V21, P239
Wild KS, 2012, J AUTISM DEV DISORD, V42, P1739, DOI 10.1007/s10803-011-1417-4
Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
Wohlschlager A, 2003, PHILOS T R SOC B, V358, P501, DOI 10.1098/rstb.2002.1257
NR 44
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1597
EP 1608
DI 10.1007/s10803-013-2027-0
PG 12
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800009
PM 24362850
ER
PT J
AU Rivard, M
Terroux, A
Parent-Boursier, C
Mercier, C
AF Rivard, Melina
Terroux, Amelie
Parent-Boursier, Claudel
Mercier, Celine
TI Determinants of Stress in Parents of Children with Autism Spectrum
Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Preschoolers; Parental stress; Early intervention
ID PERVASIVE DEVELOPMENTAL DISORDERS; BEHAVIOR PROBLEMS;
INTELLECTUAL-DISABILITY; FAMILY STRESS; MENTAL-HEALTH; DOWN-SYNDROME;
CHILDHOOD AUTISM; SYMPTOM SEVERITY; MATERNAL STRESS; FATHERS
AB Parents of children with autism spectrum disorder are known to experience more stress than parents of children with any other conditions. The current study describes the parental stress of 118 fathers and 118 mothers at the onset of their children's Early Intensive Behavioral Intervention program. The objectives of the study were to compare and analyze each parent's stress and to identify factors that might predict their stress. Results indicated that fathers reported higher levels of stress than mothers. Correlations indicated that the stress levels of both parents were associated with their child's age, intellectual quotient, severity of autistic symptoms, and adaptive behaviors. Paternal stress, but not maternal stress, was predicted by severity of autistic symptoms and child's gender. Results are discussed in terms of their implications for services and early interventions.
C1 [Rivard, Melina; Parent-Boursier, Claudel] Univ Quebec, Dept Psychol, Montreal, PQ H3C 3P8, Canada.
[Terroux, Amelie] Ctr Readaptat Deficience Intellectuelle & Trouble, Quebec City, PQ, Canada.
[Mercier, Celine] Univ Montreal, Dept Med Sociale & Prevent, Montreal, PQ, Canada.
RP Rivard, M (reprint author), Univ Quebec, Dept Psychol, CP 8888 Succursale Ctr Ville, Montreal, PQ H3C 3P8, Canada.
EM rivard.melina@uqam.ca
CR Abidin RR, 1995, PARENTING STRESS IND
American Association on Intellectual and Developmental Disabilities, 2011, INTELLECTUAL DISABIL
American Psychiatric Association, 2000, DIAG STAT MAN MENT D
Anthony LG, 2005, INFANT CHILD DEV, V14, P133, DOI 10.1002/icd.385
Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
Ballard K., 1997, INT J DISABIL DEV ED, V44, P229, DOI [10.1080/0156655970440305, DOI 10.1080/0156655970440305]
BEBKO JM, 1987, J AUTISM DEV DISORD, V17, P565, DOI 10.1007/BF01486971
Bendixen RM, 2011, AM J OCCUP THER, V65, P679, DOI 10.5014/ajot.2011.001271
Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6
Briggs-Gowan MJ, 1998, INF MENTAL HLTH J, V19, P422, DOI 10.1002/(SICI)1097-0355(199824)19:4<422::AID-IMHJ5>3.0.CO;2-U
Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488
Crnic KA, 2005, INFANT CHILD DEV, V14, P117, DOI 10.1002/icd.384
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
Flippin M, 2011, J EARLY INTERVENTION, V33, P24, DOI 10.1177/1053815111400415
FREEMAN NL, 1991, J CHILD PSYCHOL PSYC, V32, P1025, DOI 10.1111/j.1469-7610.1991.tb01927.x
Griffith GM, 2010, J AUTISM DEV DISORD, V40, P610, DOI 10.1007/s10803-009-0906-1
Hall Heather R, 2011, Issues Compr Pediatr Nurs, V34, P4, DOI 10.3109/01460862.2011.555270
Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2
Hastings RP, 2005, AUTISM, V9, P377, DOI 10.1177/1362361305056078
Hastings RP, 2001, J AUTISM DEV DISORD, V31, P327, DOI 10.1023/A:1010799320795
Herbert E., 1994, CHILDREN SOC, V8, P31, DOI [10.1111/j.1099-0860.1994.tb00412.x, DOI 10.1111/J.1099-0860.1994.TB00412.X]
Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
HOLROYD J, 1976, AM J MENT DEF, V80, P431
Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017
Kasari C, 1997, J AUTISM DEV DISORD, V27, P39, DOI 10.1023/A:1025869105208
Kayfitz AD, 2010, J APPL RES INTELLECT, V23, P337, DOI 10.1111/j.1468-3148.2009.00539.x
KOESKE GF, 1990, AM J ORTHOPSYCHIAT, V60, P440, DOI 10.1037/h0079164
KONSTANTAREAS MM, 1989, J CHILD PSYCHOL PSYC, V30, P459, DOI 10.1111/j.1469-7610.1989.tb00259.x
KONSTANTAREAS MM, 1992, J AUTISM DEV DISORD, V22, P217, DOI 10.1007/BF01058152
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
MacDonald E. E., 2010, ROLE FATHER CHILD DE, V5th, P486
Marsiglio W, 2000, J MARRIAGE FAM, V62, P1173, DOI 10.1111/j.1741-3737.2000.01173.x
MILGRAM NA, 1988, J AUTISM DEV DISORD, V18, P415, DOI 10.1007/BF02212196
Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
Osborne LA, 2008, RES AUTISM SPECT DIS, V2, P707, DOI 10.1016/j.rasd.2008.02.005
Peters-Scheffer N, 2012, RES AUTISM SPECT DIS, V6, P696, DOI 10.1016/j.rasd.2011.10.003
Phetrasuwan S, 2009, J SPEC PEDIATR NURS, V14, P157, DOI 10.1111/j.1744-6155.2009.00188.x
Pleck J., 2004, ROLE FATHER CHILD DE, V4th, P222
RODRIGUE JR, 1992, J AUTISM DEV DISORD, V22, P249, DOI 10.1007/BF01058154
Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02
Schalock RL, 2007, INTELLECT DEV DISAB, V45, P116, DOI 10.1352/1934-9556(2007)45[116:TROMRU]2.0.CO;2
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shannon JD, 2002, PARENT-SCI PRACT, V2, P77, DOI 10.1207/S15327922PAR0202_01
Sparrow S. S., 2005, VINELAND
Strauss K, 2012, RES DEV DISABIL, V33, P688, DOI 10.1016/j.ridd.2011.11.008
SZATMARI P, 1994, J AUTISM DEV DISORD, V24, P703, DOI 10.1007/BF02172281
Tobing LE, 2002, RES DEV DISABIL, V23, P211, DOI 10.1016/S0891-4222(02)00099-9
Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
Williford AP, 2007, J ABNORM CHILD PSYCH, V35, P251, DOI 10.1007/s10802-006-9082-3
WOLF LC, 1989, J AUTISM DEV DISORD, V19, P157, DOI 10.1007/BF02212727
NR 58
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1609
EP 1620
DI 10.1007/s10803-013-2028-z
PG 12
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800010
PM 24384673
ER
PT J
AU Windham, GC
Smith, KS
Rosen, N
Anderson, MC
Grether, JK
Coolman, RB
Harris, S
AF Windham, Gayle C.
Smith, Karen S.
Rosen, Nila
Anderson, Meredith C.
Grether, Judith K.
Coolman, Richard B.
Harris, Stephen
TI Autism and Developmental Screening in a Public, Primary Care Setting
Primarily Serving Hispanics: Challenges and Results
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Developmental screening; M-CHAT; ASQ;
Hispanics; Children's health
ID SPECTRUM DISORDERS; MODIFIED CHECKLIST; YOUNG-CHILDREN; TODDLERS;
QUESTIONNAIRES; PREVALENCE; COMMUNITY; RISK
AB We implemented screening of children 16-30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2-2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population.
C1 [Windham, Gayle C.; Grether, Judith K.] Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Richmond, CA 94804 USA.
[Smith, Karen S.; Rosen, Nila; Anderson, Meredith C.] Impact Assessment Inc, La Jolla, CA USA.
[Coolman, Richard B.; Harris, Stephen] Santa Clara Cty Hlth & Hosp Syst, San Jose, CA USA.
[Rosen, Nila] Univ Calif, Berkeley, CA USA.
RP Windham, GC (reprint author), Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, 850 Marina Bay Pkwy,Bldg P, Richmond, CA 94804 USA.
EM gayle.windham@cdph.ca.gov
CR Albores-Gallo L, 2012, ISRN NEUROL, V2012, DOI [DOI 10.5402/2012/408694, 10.5402/2012/408694]
BARONCOHEN S, 1996, BRIT J PSYCHIAT, V168, P158, DOI DOI 10.1192/BJP.168.2.158
Bryson SE, 2003, CAN J PSYCHIAT, V48, P506
California Department of Developmental Services (CA DDS), 2003, AUT SPECTR DIS CHANG
Canal-Bedia R, 2011, J AUTISM DEV DISORD, V41, P1342, DOI 10.1007/s10803-010-1163-z
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Centers for Disease Control and Prevention, 2007, MMWR SURVEILL SUMM, V56, P12
Chlebowski C, 2013, PEDIATRICS, V131, pE1121, DOI 10.1542/peds.2012-1525
Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
Dawson G., 1997, EFFECTIVENESS EARLY, P307
Dobrez D, 2001, PEDIATRICS, V108, P913, DOI 10.1542/peds.108.4.913
Durkin MS, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011551
Fujiwara T, 2014, J AUTISM DEV DISORD, V44, P1323, DOI 10.1007/s10803-013-1988-3
Glascoe F. P., 2010, PARENTS EVALUATION D
Guzman B., 2001, C2KBR013 US CENS BUR
Kakooza-Mwesige A, 2014, AUTISM, V18, P447, DOI 10.1177/1362361313475848
King TM, 2010, PEDIATRICS, V125, P350, DOI 10.1542/peds.2009-0388
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Mandell DS, 2005, MENT RETARD DEV D R, V11, P110, DOI 10.1002/mrdd.20061
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Miller JS, 2011, PEDIATRICS, V127, P866, DOI 10.1542/peds.2010-0136
Pandey J, 2008, AUTISM, V12, P513, DOI 10.1177/1362361308094503
Pedersen A, 2012, PEDIATRICS, V129, pE629, DOI 10.1542/peds.2011-1145
Perera H, 2009, J TROP PEDIATRICS, V55, P402, DOI 10.1093/tropej/fmp031
Pinto-Martin JA, 2008, J DEV BEHAV PEDIATR, V29, P345, DOI 10.1097/DBP.0b013e31818914cf
Robins D. L., 1999, FOLLOW INTERVIEW MOD
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Rydz D, 2006, PEDIATRICS, V118, pE1178, DOI 10.1542/peds.2006-0466
Sand N, 2005, PEDIATRICS, V116, P174, DOI 10.1542/peds.2004-1809
Scarpa A, 2013, J AUTISM DEV DISORD, V43, P2269, DOI 10.1007/s10803-013-1779-x
Sices L, 2003, J DEV BEHAV PEDIATR, V24, P409, DOI 10.1097/00004703-200312000-00002
Squires J, 1997, J PEDIATR PSYCHOL, V22, P313, DOI 10.1093/jpepsy/22.3.313
Tek S, 2012, J AUTISM DEV DISORD, V42, P1967, DOI 10.1007/s10803-012-1445-8
U.S. Census Bureau, 2012, HISP POP US 2012
Wetherby A. M., 2002, CSBS DP MANUAL COMMU
Windham GC, 2011, J AUTISM DEV DISORD, V41, P1362, DOI 10.1007/s10803-010-1160-2
Yama B, 2012, J AUTISM DEV DISORD, V42, P23, DOI 10.1007/s10803-011-1211-3
Zuckerman KE, 2013, PEDIATRICS, V132, P445, DOI 10.1542/peds.2013-0383
NR 43
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1621
EP 1632
DI 10.1007/s10803-014-2032-y
PG 12
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800011
PM 24408091
ER
PT J
AU Xiao, Z
Qiu, T
Ke, XY
Xiao, X
Xiao, T
Liang, FJ
Zou, B
Huang, HQ
Fang, H
Chu, KK
Zhang, JP
Liu, YJ
AF Xiao, Zhou
Qiu, Ting
Ke, Xiaoyan
Xiao, Xiang
Xiao, Ting
Liang, Fengjing
Zou, Bing
Huang, Haiqing
Fang, Hui
Chu, Kangkang
Zhang, Jiuping
Liu, Yijun
TI Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence
from the Brain Imaging Abnormalities in 2-3 Years Old Toddlers
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Toddler; Magnetic resonance imaging; Voxel
based morphometry; Diffusion tensor imaging
ID CORPUS-CALLOSUM MICROSTRUCTURE; EMPATHY QUOTIENT EQ; WHITE-MATTER;
SEX-DIFFERENCES; REPETITIVE BEHAVIOR; FETAL TESTOSTERONE; HEAD
CIRCUMFERENCE; YOUNG-CHILDREN; GRAY-MATTER; GENDER
AB Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3 years of life, which is marked by social skills and communication deficits along with stereotyped repetitive behavior. Although great efforts have been made to clarify the underlying neuroanatomical abnormalities and brain-behavior relationships in adolescents and adults with ASD, literature is still limited in information about the neurobiology of ASD in the early age of life. Brain images of 50 toddlers with ASD and 28 age, gender, and developmental quotient matched toddlers with developmental delay (DD) (control group) between ages 2 and 3 years were captured using combined magnetic resonance-based structural imaging and diffusion tensor imaging (DTI). Structural magnetic resonance imaging was applied to assess overall gray matter (GM) and white matter (WM) volumes, and regional alterations were assessed by voxel-based morphometry. DTI was used to investigate the white matter tract integrity. Compared with DD, significant increases were observed in ASD, primarily in global GM and WM volumes and in right superior temporal gyrus regional GM and WM volumes. Higher fractional anisotropy value was also observed in the corpus callosum, posterior cingulate cortex, and limbic lobes of ASD. The converging findings of structural and white matter abnormalities in ASD suggest that alterations in neural-anatomy of different brain regions may be involved in behavioral and cognitive deficits associated with ASD, especially in an early age of 2-3 years old toddlers.
C1 [Xiao, Zhou; Qiu, Ting; Ke, Xiaoyan; Xiao, Xiang; Xiao, Ting; Liang, Fengjing; Zou, Bing; Fang, Hui; Chu, Kangkang; Zhang, Jiuping] Nanjing Med Univ, Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing 210029, Jiangsu, Peoples R China.
[Huang, Haiqing; Liu, Yijun] Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32601 USA.
RP Ke, XY (reprint author), Nanjing Med Univ, Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing GuangZhou Rd 264, Nanjing 210029, Jiangsu, Peoples R China.
EM kexynj@hotmail.com
CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Aoki Y., 2013, MOL AUTISM, V22, P25, DOI DOI 10.1186/2040-2392-4-25
Badaruddin DH, 2007, CHILD PSYCHIAT HUM D, V38, P287, DOI 10.1007/s10578-007-0065-6
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Barnea G. N., 2004, BIOL PSYCHIAT, V55, P323
Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Billeci L, 2012, BMC NEUROL, V12, DOI 10.1186/1471-2377-12-148
Brown WS, 2005, BRAIN LANG, V93, P135, DOI 10.1016/j.bandl.2004.09.003
Brown WS, 2005, NEUROPSYCHOLOGIA, V43, P906, DOI 10.1016/j.neuropsychologia.2004.09.008
Brynska A, 2012, PSYCHIATR POL, V46, P1053
Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099
Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
Cheng YW, 2010, NEUROIMAGE, V50, P873, DOI 10.1016/j.neuroimage.2010.01.011
Cosgrove KP, 2007, BIOL PSYCHIAT, V62, P847, DOI 10.1016/j.biopsych.2007.03.001
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
Courchesne E, 2004, CURR OPIN NEUROL, V17, P489, DOI 10.1097/01.wco.0000137542.14610.b4
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8
Gillberg C, 2006, J AUTISM DEV DISORD, V36, P429, DOI 10.1007/s10803-006-0081-6
Good CD, 2001, NEUROIMAGE, V14, P685, DOI 10.1006/nimg.2001.0857
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
Huster RJ, 2009, HUM BRAIN MAPP, V30, P383, DOI 10.1002/hbm.20509
Inano S, 2011, AM J NEURORADIOL, V32, P2103, DOI 10.3174/ajnr.A2785
Jones DK, 2010, NMR BIOMED, V23, P803, DOI 10.1002/nbm.1543
Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
Knickmeyer RC, 2006, J CHILD NEUROL, V21, P825, DOI 10.2310/7010.2006.00213
Liu F, 2010, BRAIN RES, V1343, P37, DOI 10.1016/j.brainres.2010.04.064
Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
Luders E, 2005, NEUROIMAGE, V26, P493, DOI 10.1016/j.neuroimage.2005.02.010
Menzler K, 2011, NEUROIMAGE, V54, P2557, DOI 10.1016/j.neuroimage.2010.11.029
Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
Muratori F, 2012, RES AUTISM SPECT DIS, V6, P442, DOI 10.1016/j.rasd.2011.07.004
Nordahl CW, 2012, ARCH GEN PSYCHIAT, V69, P53, DOI 10.1001/archgenpsychiatry.2011.145
Oh JS, 2007, NEUROIMAGE, V36, P606, DOI 10.1016/j.neuroimage.2007.03.020
Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
Shou Y., 1993, CHINESE J CLIN PSYCH, V1, P71
Sparks BF, 2002, NEUROLOGY, V59, P184
Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099
Ulay HT, 2009, TURK PSIKIYATR DERG, V20, P164
Vos SB, 2011, NEUROIMAGE, V55, P1566, DOI 10.1016/j.neuroimage.2011.01.048
Wakabayashi A, 2007, J AUTISM DEV DISORD, V37, P1823, DOI 10.1007/s10803-006-0316-6
Walker L, 2012, BIOL PSYCHIAT, V72, P1043, DOI 10.1016/j.biopsych.2012.08.001
Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042
Westerhausen R, 2011, NEUROIMAGE, V56, P874, DOI 10.1016/j.neuroimage.2011.03.013
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
NR 51
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1633
EP 1640
DI 10.1007/s10803-014-2033-x
PG 8
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800012
PM 24419870
ER
PT J
AU Bekele, E
Crittendon, J
Zheng, Z
Swanson, A
Weitlauf, A
Warren, Z
Sarkar, N
AF Bekele, Esubalew
Crittendon, Julie
Zheng, Zhi
Swanson, Amy
Weitlauf, Amy
Warren, Zachary
Sarkar, Nilanjan
TI Assessing the Utility of a Virtual Environment for Enhancing Facial
Affect Recognition in Adolescents with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Virtual reality; Facial expressions; Adaptive
systems
ID SPECTRUM DISORDERS; REALITY ENVIRONMENTS; EMOTION RECOGNITION;
SOCIAL-INTERACTION; YOUNG-CHILDREN; EXPRESSIONS; DESIGN; FACES;
INTERVENTION; TECHNOLOGIES
AB Teenagers with autism spectrum disorder (ASD) and age-matched controls participated in a dynamic facial affect recognition task within a virtual reality (VR) environment. Participants identified the emotion of a facial expression displayed at varied levels of intensity by a computer generated avatar. The system assessed performance (i.e., accuracy, confidence ratings, response latency, and stimulus discrimination) as well as how participants used their gaze to process facial information using an eye tracker. Participants in both groups were similarly accurate at basic facial affect recognition at varied levels of intensity. Despite similar performance characteristics, ASD participants endorsed lower confidence in their responses and substantial variation in gaze patterns in absence of perceptual discrimination deficits. These results add support to the hypothesis that deficits in emotion and face recognition for individuals with ASD are related to fundamental differences in information processing. We discuss implications of this finding in a VR environment with regards to potential future applications and paradigms targeting not just enhanced performance, but enhanced social information processing within intelligent systems capable of adaptation to individual processing differences.
C1 [Bekele, Esubalew; Zheng, Zhi; Sarkar, Nilanjan] Vanderbilt Univ, Dept Elect Engn & Comp Sci, Nashville, TN 37212 USA.
[Crittendon, Julie; Weitlauf, Amy; Warren, Zachary] Vanderbilt Univ, Dept Pediat & Psychiat, Nashville, TN 37212 USA.
[Crittendon, Julie; Swanson, Amy; Weitlauf, Amy; Warren, Zachary] Vanderbilt Univ, Treatment & Res Inst Autism Spectrum Disorders, Vanderbilt Kennedy Ctr, Nashville, TN 37212 USA.
[Warren, Zachary] Vanderbilt Univ, Dept Special Educ, Nashville, TN 37212 USA.
[Sarkar, Nilanjan] Vanderbilt Univ, Dept Mech Engn, Nashville, TN 37212 USA.
RP Bekele, E (reprint author), Vanderbilt Univ, Dept Elect Engn & Comp Sci, 518 Olin Hall 2400 Highland Ave, Nashville, TN 37212 USA.
EM esubalew.bekele@vanderbilt.edu
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
Anderson CJ, 2006, J CLIN EXP NEUROPSYC, V28, P1238, DOI 10.1080/13803390500376790
Bekele E, 2013, IEEE T VIS COMPUT GR, V19, P711, DOI 10.1109/TVCG.2013.42
Blocher K., 2002, SOCIALLY INTELLIGENT, P1
Bolte S, 2010, AUTISM, V14, P155, DOI 10.1177/1362361310365028
Bolte S, 2006, BEHAV NEUROSCI, V120, P211, DOI 10.1037/0735-7044.120.1.211
CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
Constantino JN, 2005, SOCIAL RESPONSIVENES
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x
EKMAN P, 1993, AM PSYCHOL, V48, P384, DOI 10.1037//0003-066X.48.4.384
Elliott C., 2007, DIFFERENTIAL ABILITY
Golan Ofer, 2010, J Autism Dev Disord, V40, P269, DOI 10.1007/s10803-009-0862-9
Golan O., 2006, DEV PSYCHOPATHOL, V18, P589
Goodwin MS, 2008, FOCUS AUTISM DEV DIS, V23, P125, DOI 10.1177/1088357608316678
HOBSON RP, 1988, PSYCHOL MED, V18, P911
HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
Interagency Autism Coordinating Committee (IACC), 2012, IACC STRAT PLAN AUT
Kandalaft MR, 2013, J AUTISM DEV DISORD, V43, P34, DOI 10.1007/s10803-012-1544-6
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Lacava PG, 2010, AUTISM, V14, P161, DOI 10.1177/1362361310362085
Lahiri U., 2012, IEEE T NEUR SYS REH, V19, P443
Lahiri U, 2013, IEEE T NEUR SYS REH, V21, P55, DOI 10.1109/TNSRE.2012.2218618
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mitchell P, 2007, J AUTISM DEV DISORD, V37, P589, DOI 10.1007/s10803-006-0189-8
Parsons S, 2004, J AUTISM DEV DISORD, V34, P449, DOI 10.1023/B:JADD.0000037421.98517.8d
Parsons S, 2002, J INTELL DISABIL RES, V46, P430, DOI 10.1046/j.1365-2788.2002.00425.x
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Ploog BO, 2013, J AUTISM DEV DISORD, V43, P301, DOI 10.1007/s10803-012-1571-3
Ploog BO, 2010, J AUTISM DEV DISORD, V40, P1332, DOI 10.1007/s10803-010-0990-2
Rold G., 2003, STANFORD BINET INTEL
Rutter M., 2003, SOCIAL COMMUNICATION
Wechlser D., 2003, WECHSLER INTELLIGENC
Wechsler D, 1999, WECHSLER ABBREVIATED
WEEKS SJ, 1987, J CHILD PSYCHOL PSYC, V28, P137, DOI 10.1111/j.1469-7610.1987.tb00658.x
Welch KC, 2010, ADV MED BIOL, V8, P297
Welch KC, 2009, LECT NOTES COMPUT SC, V5612, P703, DOI 10.1007/978-3-642-02580-8_77
Welch KC, 2010, INT J SOC ROBOT, V2, P391, DOI 10.1007/s12369-010-0063-x
Wilms M, 2010, SOC COGN AFFECT NEUR, V5, P98, DOI 10.1093/scan/nsq024
NR 42
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1641
EP 1650
DI 10.1007/s10803-014-2035-8
PG 10
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800013
PM 24419871
ER
PT J
AU Bockler, A
Timmermans, B
Sebanz, N
Vogeley, K
Schilbach, L
AF Bockler, Anne
Timmermans, Bert
Sebanz, Natalie
Vogeley, Kai
Schilbach, Leonhard
TI Effects of Observing Eye Contact on Gaze Following in High-Functioning
Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Gaze following; Joint attention; Social cognition; High-functioning
autism
ID JOINT ATTENTION; CHILDREN; CONSCIOUSNESS; COMPETENCE; PERCEPTION;
INFANTS; FACE; MIND
AB Observing eye contact between others enhances the tendency to subsequently follow their gaze and has been suggested to function as a social signal that adds meaning to an upcoming action or event. The present study investigated effects of observed eye contact in high-functioning autism (HFA). Two faces on a screen either looked at or away from each other before providing congruent or incongruent gaze cues to one of two target locations. In contrast to control participants, HFA participants did not depict enhanced gaze following after observing eye contact. Individuals with autism, hence, do not seem to process observed mutual gaze as a social signal indicating the relevance of upcoming (gaze) behaviour. This may be based on the reduced tendency of individuals with HFA to engage in social gaze behavior themselves, and might underlie some of the characteristic deficiencies in social communicative behaviour in autism.
C1 [Bockler, Anne; Sebanz, Natalie] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
[Timmermans, Bert; Vogeley, Kai; Schilbach, Leonhard] Univ Hosp Cologne, Cologne, Germany.
[Sebanz, Natalie] Cent European Univ, Dept Cognit Sci, Budapest, Hungary.
[Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med Cognit Neurosci INM3, Julich, Germany.
RP Bockler, A (reprint author), Max Planck Inst Human Cognit & Brain Sci, Dept Social Neurosci, Stephanstr 1, D-04103 Leipzig, Germany.
EM aboeckler@cbs.mpg.de
CR BAKEMAN R, 1984, CHILD DEV, V55, P1278, DOI 10.2307/1129997
Baldwin D. A., 1995, JOINT ATTENTION ITS, p131
Baron- Cohen S., 1989, DEV PSYCHOPATHOL, V1, P185, DOI 10.1017/ S0954579400000377
Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
Baron-Cohen S., 1991, NATURAL THEORIES MIN, P233
Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Barresi J, 1996, BEHAV BRAIN SCI, V19, P107
Bayliss AP, 2005, Q J EXP PSYCHOL-A, V58, P631, DOI 10.1080/02724980443000124
Beck A. T., 1987, BECK DEPRESSION INVE
Bockler A, 2011, COGNITION, V120, P292, DOI 10.1016/j.cognition.2011.05.002
Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x
Bristow D, 2007, SOC COGN AFFECT NEUR, V2, P52, DOI 10.1093/scan/nsl036
Carhart-Harris RL, 2010, BRAIN, V133, P1265, DOI 10.1093/brain/awq010
Chawarska K, 2003, CHILD DEV, V74, P1108, DOI 10.1111/1467-8624.00595
Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
Clark A, 2013, BEHAV BRAIN SCI, V36, P233, DOI [10.1017/S0140525X12000477, 10.1017/S0140525X12002440]
Clark HH, 2004, J MEM LANG, V50, P62, DOI 10.1016/j.jml.2003.08.004
Csibra G., 2010, MIND LANG, V25, P141, DOI DOI 10.1111/J.1468-0017.2009.01384.X
Csibra G, 2009, TRENDS COGN SCI, V13, P148, DOI 10.1016/j.tics.2009.01.005
Driver J, 1999, VIS COGN, V6, P509
Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
Friesen CK, 1998, PSYCHON B REV, V5, P490, DOI 10.3758/BF03208827
Greene DJ, 2011, NEUROIMAGE, V56, P354, DOI 10.1016/j.neuroimage.2011.02.031
Ham J, 2006, ANN NY ACAD SCI, V1094, P297, DOI 10.1196/annals.1376.038
HAPPE FGE, 1993, COGNITION, V48, P101, DOI 10.1016/0010-0277(93)90026-R
Hill EL, 2003, PHILOS T R SOC B, V358, P281, DOI 10.1098/rstb.2002.1209
Kuzmanovic B, 2011, RES AUTISM SPECT DIS, V5, P604, DOI 10.1016/j.rasd.2010.07.005
Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
Kylliainen A, 2004, J CHILD PSYCHOL PSYC, V45, P435, DOI 10.1111/j.1469-7610.2004.00235.x
LOFTUS GR, 1994, PSYCHON B REV, V1, P476, DOI 10.3758/BF03210951
Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165
MUNDY P, 1994, DEV PSYCHOPATHOL, V6, P389, DOI 10.1017/S0954579400006003
Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
Pierno AC, 2006, J COGNITIVE NEUROSCI, V18, P2130, DOI 10.1162/jocn.2006.18.12.2130
Reddy V, 2003, TRENDS COGN SCI, V7, P397, DOI 10.1016/S1364-6613(03)00191-8
Richardson DC, 2005, COGNITIVE SCI, V29, P1045, DOI 10.1207/s15516709cog0000_29
Schilbach L, 2010, J COGNITIVE NEUROSCI, V22, P2702, DOI 10.1162/jocn.2009.21401
Schilbach L, 2012, AUTISM, V16, P151, DOI 10.1177/1362361311409258
Schilbach Leonhard, 2010, Nat Rev Neurosci, V11, P449, DOI 10.1038/nrn2805-c1
Schilbach L, 2013, BEHAV BRAIN SCI, V36, P393, DOI 10.1017/S0140525X12000660
Schilbach L., 2012, PLOS ONE
Schilbach L., 2010, SOC COGN AFFECT NEUR, V6, P393
Sebanz N, 2006, TRENDS COGN SCI, V10, P70, DOI 10.1016/j.tics.2005.12.009
Sebanz N, 2005, COGN NEUROPSYCHOL, V22, P433, DOI 10.1080/02643290442000121
Senju A, 2008, CURR BIOL, V18, P668, DOI 10.1016/j.cub.2008.03.059
Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
Striano T, 2006, EUR J NEUROSCI, V23, P2819, DOI 10.1111/j.1460-9568.2006.04822.x
Timmermans B, 2012, PHILOS T R SOC B, V367, P1412, DOI 10.1098/rstb.2011.0421
Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
Tomasello M, 2007, DEVELOPMENTAL SCI, V10, P121, DOI 10.1111/j.1467-7687.2007.00573.x
Wang Y, 2011, BIOL LETTERS, V7, P7, DOI 10.1098/rsbl.2010.0279
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
Yoon JMD, 2008, P NATL ACAD SCI USA, V105, P13690, DOI 10.1073/pnas.0804388105
Zwickel J., 2010, SOCIAL COGNITIVE AFF, V6, P564
NR 58
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1651
EP 1658
DI 10.1007/s10803-014-2038-5
PG 8
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800014
PM 24442835
ER
PT J
AU Nijmeijer, JS
Arias-Vasquez, A
Rommelse, NNJ
Altink, ME
Buschgens, CJM
Fliers, EA
Franke, B
Minderaa, RB
Sergeant, JA
Buitelaar, JK
Hoekstra, PJ
Hartman, CA
AF Nijmeijer, Judith S.
Arias-Vasquez, Alejandro
Rommelse, Nanda N. J.
Altink, Marieke E.
Buschgens, Cathelijne J. M.
Fliers, Ellen A.
Franke, Barbara
Minderaa, Ruud B.
Sergeant, Joseph A.
Buitelaar, Jan K.
Hoekstra, Pieter J.
Hartman, Catharina A.
TI Quantitative Linkage for Autism Spectrum Disorders Symptoms in
Attention-Deficit/Hyperactivity Disorder: Significant Locus on
Chromosome 7q11
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; ADHD; Comorbidity; Genetics
ID DEFICIT HYPERACTIVITY DISORDER; WILLIAMS-BEUREN-SYNDROME;
GENERAL-POPULATION; GENETIC INFLUENCES; SOCIAL-BEHAVIOR; TWIN SAMPLE;
SIB PAIRS; GENOME; TRAITS; SCAN
AB We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.
C1 [Minderaa, Ruud B.; Hoekstra, Pieter J.; Hartman, Catharina A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9700 AR Groningen, Netherlands.
[Nijmeijer, Judith S.] Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, NL-9700 AR Groningen, Netherlands.
[Arias-Vasquez, Alejandro; Altink, Marieke E.; Fliers, Ellen A.; Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands.
[Arias-Vasquez, Alejandro; Buschgens, Cathelijne J. M.; Fliers, Ellen A.; Franke, Barbara; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
[Rommelse, Nanda N. J.; Buschgens, Cathelijne J. M.; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
[Rommelse, Nanda N. J.; Altink, Marieke E.; Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Med Ctr, Nijmegen, Netherlands.
[Rommelse, Nanda N. J.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands.
[Fliers, Ellen A.] Parnassia BAVO Grp, Youth Dept, Rotterdam, Netherlands.
[Sergeant, Joseph A.] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands.
RP Nijmeijer, JS (reprint author), Univ Groningen, Dept Child & Adolescent Psychiat, Hanzepl 1,POB 660, NL-9700 AR Groningen, Netherlands.
EM j.nijmeijer@accare.nl
RI Hoekstra, Pieter/O-4396-2014; Franke, Barbara/D-4836-2009
OI Franke, Barbara/0000-0003-4375-6572
CR Abecasis GR, 2005, AM J HUM GENET, V77, P754, DOI 10.1086/497345
Abecasis GR, 2002, NAT GENET, V30, P97, DOI 10.1038/ng786
Allen-Brady K, 2009, MOL PSYCHIATR, V14, P590, DOI 10.1038/mp.2008.14
Almasy L, 1998, AM J HUM GENET, V62, P1198, DOI 10.1086/301844
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Asherson P, 2008, MOL PSYCHIATR, V13, P514, DOI 10.1038/sj.mp.4002140
Bakker SC, 2003, AM J HUM GENET, V72, P1251, DOI 10.1086/375143
Berg JS, 2007, GENET MED, V9, P427, DOI 10.1097/GIM.0b013e3180986192
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Brookes K, 2006, MOL PSYCHIATR, V11, P934, DOI 10.1038/sj.mp.4001869
Conners K., 1996, RATING SCLAES ADHD
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2011, PEDIATR RES, V69, p55R, DOI 10.1203/PDR.0b013e318212ec6e
Constantino JN, 2000, AM J PSYCHIAT, V157, P2043, DOI 10.1176/appi.ajp.157.12.2043
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Depienne C, 2007, J MED GENET, V44, P452, DOI 10.1136/jmg.2006.047092
Epstein MP, 2000, AM J HUM GENET, V67, P1219
Faraone SV, 2008, AM J MED GENET B, V147B, P1387, DOI 10.1002/ajmg.b.30631
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Hartman C. A., 2007, VRAGENLIJST VOOR INV
Hartman CA, 2006, J AUTISM DEV DISORD, V36, P325, DOI 10.1007/s10803-005-0072-z
Kong A, 2002, NAT GENET, V31, P241, DOI 10.1038/ng917
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Kuntsi Jonna, 2006, Behav Brain Funct, V2, P27, DOI 10.1186/1744-9081-2-27
LANDER E, 1995, NAT GENET, V11, P241, DOI 10.1038/ng1195-241
Ligthart L, 2008, AM J MED GENET B, V147B, P1186, DOI 10.1002/ajmg.b.30749
Luteijn EF, 2000, EUR CHILD ADOLES PSY, V9, P168
Neale BM, 2008, AM J MED GENET B, V147B, P1337, DOI 10.1002/ajmg.b.30866
Nijmeijer J. S., 2008, J ABNORMAL CHILD PSY, V37, P443, DOI DOI 10.1007/S10802-008-9282-0
Nijmeijer JS, 2008, CLIN PSYCHOL REV, V28, P692, DOI 10.1016/j.cpr.2007.10.003
O'Connell JR, 1998, AM J HUM GENET, V63, P259, DOI 10.1086/301904
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Sham PC, 2002, AM J HUM GENET, V71, P238, DOI 10.1086/341560
Spiker D, 2002, AM J MED GENET, V114, P129, DOI 10.1002/ajmg.10188
Sultana R, 2002, GENOMICS, V80, P129, DOI 10.1006/geno.2002.6810
TAYLOR E, 1986, BRIT J PSYCHIAT, V149, P760, DOI 10.1192/bjp.149.6.760
Vandeweyer G, 2012, AM J HUM GENET, V90, P1071, DOI 10.1016/j.ajhg.2012.04.020
Waldman ID, 2006, CLIN PSYCHOL REV, V26, P396, DOI 10.1016/j.cpr.2006.01.007
Wigginton JE, 2005, BIOINFORMATICS, V21, P3445, DOI 10.1093/bioinformatics/bti529
Yang MS, 2007, INT J DEV NEUROSCI, V25, P69, DOI 10.1016/j.ijdevneu.2006.12.002
Zhou KX, 2008, BIOL PSYCHIAT, V64, P571, DOI 10.1016/j.biopsych.2008.02.024
Zhou KX, 2008, AM J MED GENET B, V147B, P1392, DOI 10.1002/ajmg.b.30878
NR 49
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1671
EP 1680
DI 10.1007/s10803-014-2039-4
PG 10
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800016
PM 24526336
ER
PT J
AU Suh, J
Eigsti, IM
Naigles, L
Barton, M
Kelley, E
Fein, D
AF Suh, Joyce
Eigsti, Inge-Marie
Naigles, Letitia
Barton, Marianne
Kelley, Elizabeth
Fein, Deborah
TI Narrative Performance of Optimal Outcome Children and Adolescents with a
History of an Autism Spectrum Disorder (ASD)
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Outcome; Optimal; Narrative; Language; Pragmatics; Dysfluency
ID HIGH-FUNCTIONING AUTISM; LANGUAGE DISORDERS; ASPERGER-SYNDROME;
BEHAVIORAL TREATMENT; INDIVIDUALS; IMPAIRMENTS; ADULTS; DISCOURSE;
ABILITY; AGE
AB Autism Spectrum Disorders (ASDs) have traditionally been considered a lifelong condition; however, a subset of people makes such significant improvements that they no longer meet diagnostic criteria for an ASD. The current study examines whether these "optimal outcome" (OO) children and adolescents continue to have subtle pragmatic language deficits. The narratives of 15 OO individuals, 15 high-functioning individuals with an ASD (HFA), and 15 typically developing (TD) peers were evaluated. Despite average cognitive functioning, the ASD group produced narratives with fewer central "gist" descriptions, more ambiguous pronominal referents, idiosyncratic language, speech dysfluency (more repetitions and self-corrections), and were less likely to name story characters. The OO participants displayed only very subtle pragmatic and higher-level language deficits (idiosyncratic language and self-correction dysfluency).
C1 [Suh, Joyce; Eigsti, Inge-Marie; Naigles, Letitia; Barton, Marianne; Fein, Deborah] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
[Kelley, Elizabeth] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
[Fein, Deborah] Univ Connecticut, Dept Pediat, Farmington, CT USA.
RP Suh, J (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd,Unit 1020, Storrs, CT 06269 USA.
EM joyce.suh@uconn.edu
CR Association Psychiatric Assocaition, 2000, DIAGN STAT MAN MENT
Baldwin D., 2007, LANGUAGE DEV
Barnes JL, 2012, J AUTISM DEV DISORD, V42, P1557, DOI 10.1007/s10803-011-1388-5
Beaumont R, 2006, AUTISM, V10, P365, DOI 10.1177/1362361306064416
Belardi K. M., 2009, INT M AUT RES CHIC
Bortfeld H, 2001, LANG SPEECH, V44, P123
Botting N, 2002, CHILD LANG TEACH THE, V18, P1, DOI 10.1191/0265659002ct224oa
Capps L., 2000, J ABNORMAL CHILD PSY, V28, P193
Clark H. H., 1996, USING LANGUAGE
Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
Diehl JJ, 2006, J ABNORM CHILD PSYCH, V34, P87, DOI 10.1007/s10802-005-9003-x
Edelson L. R., 2012, CUES PRONOMIAL REFER
Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2
Engelhardt PE, 2013, ACTA PSYCHOL, V144, P424, DOI 10.1016/j.actpsy.2013.08.002
Fein D, 2005, J AUTISM DEV DISORD, V35, P525, DOI 10.1007/s10803-005-5066-3
Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037
Geurts H, 2010, INT J LANG COMM DIS, V45, P436, DOI 10.3109/13682820903165685
Ghaziuddin M, 1996, J AUTISM DEV DISORD, V26, P585, DOI 10.1007/BF02172348
Goldman S, 2008, J AUTISM DEV DISORD, V38, P1982, DOI 10.1007/s10803-008-0588-0
Grice H., 1975, SYNTAX SEMANTICS, V3
Heeman P. A., 2010, 11 ANN M SPEC INT GR
Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
HUNT E, 1965, J VERB LEARN VERB BE, V4, P211, DOI 10.1016/S0022-5371(65)80022-6
Karmiloff-Smith A., 1985, ARCH PSYCHOL, V53, P113
Kelley E, 2010, RES AUTISM SPECT DIS, V4, P526, DOI 10.1016/j.rasd.2009.12.001
Kelley E, 2006, J AUTISM DEV DISORD, V36, P807, DOI 10.1007/s10803-006-0111-4
Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
Lake JK, 2011, PSYCHON B REV, V18, P135, DOI 10.3758/s13423-010-0037-x
LANDA R, 1991, J SPEECH HEAR RES, V34, P1339
LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
Lord C., 2000, AUTISM DIAGNOSTIC OB
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
LOVELAND KA, 1990, BRIT J DEV PSYCHOL, V8, P9
MacWhinney B., 2000, CHILDES PROJECT TOOL
Mayo J, 2013, J AUTISM DEV DISORD, V43, P253, DOI 10.1007/s10803-012-1558-0
Naigles LR, 2013, J AUTISM DEV DISORD, V43, P2048, DOI 10.1007/s10803-012-1754-y
Naigles LR, 2011, AUTISM RES, V4, P422, DOI 10.1002/aur.223
Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
Perneger TV, 1998, BRIT MED J, V316, P1236
PERRY R, 1995, J AM ACAD CHILD PSY, V34, P232, DOI 10.1097/00004583-199502000-00019
Petersen DB, 2010, J SPEECH LANG HEAR R, V53, P961, DOI 10.1044/1092-4388(2009/09-0001)
Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
Piven J, 1997, AM J PSYCHIAT, V154, P185
Rapin I, 2009, DEV NEUROPSYCHOL, V34, P66, DOI 10.1080/87565640802564648
Rapin I, 2003, BRAIN DEV-JPN, V25, P166, DOI 10.1016/S0387-7604(02)00191-2
RATNER NB, 1987, J SPEECH HEAR DISORD, V52, P278
Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
Schuh J. M., 2012, PRAGMATIC LANGUAGE A
Sherratt S, 2007, APHASIOLOGY, V21, P375, DOI 10.1080/02687030600911435
SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420
Sparrow S, 1984, VINELAND ADAPTIVE BE
Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842
Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335
TAGERFLUSBERG H, 1992, CHILD DEV, V63, P161, DOI 10.1111/j.1467-8624.1992.tb03604.x
Tager-Flusberg H, 2001, INT REV RES MENT RET, V23, P185
TAGERFLUSBERG H, 1995, APPL PSYCHOLINGUIST, V16, P241, DOI 10.1017/S0142716400007281
Tree JEF, 2001, MEM COGNITION, V29, P320
Wechsler D, 1999, WECHSLER ABBREVIATED
Wiesner D., 1991, TUESDAY
Young EC, 2005, LANG SPEECH HEAR SER, V36, P62, DOI 10.1044/0161-1461(2005/006)
Zappella M, 2010, BRAIN DEV-JPN, V32, P739, DOI 10.1016/j.braindev.2010.05.004
NR 64
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1681
EP 1694
DI 10.1007/s10803-014-2042-9
PG 14
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800017
PM 24500659
ER
PT J
AU Moss, AHB
Gordon, JE
O'Connell, A
AF Moss, Alicia H. B.
Gordon, Jocelynne E.
O'Connell, Annie
TI Impact of Sleepwise: An Intervention for Youth with Developmental
Disabilities and Sleep Disturbance
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Children; Adolescents; Sleep problem; Treatment; Developmental
disabilities; Parent
ID AUTISM SPECTRUM DISORDERS; RANDOMIZED CONTROLLED-TRIAL;
PLACEBO-CONTROLLED TRIAL; INDEX-SHORT FORM; NEURODEVELOPMENTAL
DISORDERS; ASPERGER-SYNDROME; CONDUCT PROBLEMS; YOUNG-CHILDREN;
DOWN-SYNDROME; INTELLECTUAL DISABILITY
AB The prevalence of sleep disturbance among children with developmental disabilities is known to be considerably higher than the typical population. The current study examined the effectiveness of the Sleepwise intervention program (O'Connell and Vannan in Aust Occup Ther J 55:212-214, 2008): a parent-assisted group-based treatment for sleep disturbance which was recently adapted for older children and adolescents with DD. Twenty-six families with children aged 8-17 years participated. The study compared a treatment and a wait-list control group at baseline, post-treatment and 2 months post-treatment on measures of child and parent functioning. Results demonstrated that the Sleepwise approach was effective in reducing sleep disturbance and parent stress. Limitations and future research directions are discussed.
C1 [Moss, Alicia H. B.; Gordon, Jocelynne E.] Monash Univ, Fac Educ, Melbourne, Vic 3800, Australia.
[O'Connell, Annie] Govt South Australia, Dept Commun & Social Inclus, Disabil Serv, Adelaide, SA, Australia.
RP Gordon, JE (reprint author), Monash Univ, Fac Educ, Bldg 6, Melbourne, Vic 3800, Australia.
EM jocelynne.gordon@monash.edu
CR Abidin R. R., 1995, PARENTING STREES IND
Allik H, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-18
Allik H, 2006, J AUTISM DEV DISORD, V36, P585, DOI 10.1007/s10803-006-0099-9
American Academy of Sleep Medicine, 2005, INT CLASS SLEEP DIS, V2nd
Appleton RE, 2012, HEALTH TECHNOL ASSES, V16, P1, DOI 10.3310/hta16400
Balfour A. M., 1988, HLTH VISITOR, V6, P316
Bartlet L., 1998, CLIN CHILD PSYCHOL P, V3, P591, DOI [10.1177/1359104598034010, DOI 10.1177/1359104598034010]
Szyndler J, 1992, Health Visit, V65, P277
BRIGHTMAN RP, 1982, J BEHAV THER EXP PSY, V13, P113, DOI 10.1016/0005-7916(82)90051-9
Carpenter A, 1990, Health Visit, V63, P305
Chadwick O, 2001, BEHAV COGN PSYCHOTH, V29, P151, DOI 10.1017/S135246580100203X
Chu J, 2009, RES DEV DISABIL, V30, P1512, DOI 10.1016/j.ridd.2009.07.007
Churchill SS, 2012, SLEEP MED REV, V16, P477, DOI 10.1016/j.smrv.2011.10.003
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Cortesi F, 2010, SLEEP MED, V11, P659, DOI 10.1016/j.sleep.2010.01.010
Cortesi F, 2012, J SLEEP RES, V21, P700, DOI 10.1111/j.1365-2869.2012.01021.x
Cotton S, 2006, RES DEV DISABIL, V27, P151, DOI 10.1016/j.ridd.2004.12.003
CUNNINGHAM CE, 1995, J CHILD PSYCHOL PSYC, V36, P1141, DOI 10.1111/j.1469-7610.1995.tb01362.x
Dekker MC, 2002, J INTELL DISABIL RES, V46, P285
De Leersnyder H, 2011, PEDIATR NEUROL, V45, P23, DOI 10.1016/j.pediatrneurol.2011.02.001
Didden R, 2001, RES DEV DISABIL, V22, P255, DOI 10.1016/S0891-4222(01)00071-3
Didden R, 2002, J INTELL DISABIL RES, V46, P537, DOI 10.1046/j.1365-2788.2002.00404.x
Drugli MB, 2010, J CHILD PSYCHOL PSYC, V51, P559, DOI 10.1111/j.1469-7610.2009.02178.x
Einfeld S. L., 2002, MANUAL DEV BEHAV CHE
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Gallagher S, 2010, J PEDIATR PSYCHOL, V35, P728, DOI 10.1093/jpepsy/jsp093
Goldman SE, 2012, J INTELL DISABIL RES, V56, P600, DOI 10.1111/j.1365-2788.2011.01499.x
Goldman SE, 2012, J AUTISM DEV DISORD, V42, P531, DOI 10.1007/s10803-011-1270-5
Gringras P, 2012, BRIT MED J, V345, DOI 10.1136/bmj.e6664
Hagen KA, 2011, J CLIN CHILD ADOLESC, V40, P165, DOI 10.1080/15374416.2011.546050
Hare DJ, 2006, AUTISM, V10, P565, DOI 10.1177/1362361306068S09
Haskett ME, 2006, J CLIN CHILD ADOLESC, V35, P302, DOI 10.1207/s15374424jccp3502_14
Hoffman C. D., 2006, FOCUS AUTISM OTHER D, V21, P146, DOI [10.1177/10883576060210030301, DOI 10.1177/1088357]
Hoffman CD, 2008, FOCUS AUTISM DEV DIS, V23, P155, DOI 10.1177/1088357608316271
Honomichl RD, 2002, J AUTISM DEV DISORD, V32, P553, DOI 10.1023/A:1021254914276
Hudson AM, 2003, J INTELL DISABIL RES, V47, P238, DOI 10.1046/j.1365-2788.2003.00486.x
Jalali M., 2008, J FAMILY RES, V4, P353
Jan JE, 2008, PEDIATRICS, V122, P1343, DOI 10.1542/peds.2007-3308
Kjobli J, 2013, BEHAV RES THER, V51, P113, DOI 10.1016/j.brat.2012.11.006
Koegel RL, 2002, J POSIT BEHAV INTERV, V4, P88, DOI 10.1177/109830070200400204
Kotagal S, 2012, PEDIATR NEUROL, V47, P242, DOI 10.1016/j.pediatrneurol.2012.05.007
Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x
Lach LM, 2009, DISABIL REHABIL, V31, P607, DOI 10.1080/09638280802242163
Larsson B, 2009, EUR CHILD ADOLES PSY, V18, P42, DOI 10.1007/s00787-008-0702-z
Limoges E, 2005, BRAIN, V128, P1049, DOI 10.1093/brain/awh425
Lopez-Wagner MC, 2008, J GENET PSYCHOL, V169, P245, DOI 10.3200/GNTP.169.3.245-260
Manning-Courtney P, 2013, CURR PROB PEDIATR AD, V43, P2, DOI 10.1016/j.cppeds.2012.08.001
Matson JL, 2008, J MENT HEALTH RES IN, V1, P129, DOI 10.1080/19315860801988210
Maulik PK, 2011, RES DEV DISABIL, V32, P419, DOI 10.1016/j.ridd.2010.12.018
McDonald J., 2012, AUSTR ED DEV PSYCHOL, V29, P52, DOI [10.1017/edp.2012.9, DOI 10.1017/EDP.2012.9]
Meltzer LJ, 2008, J PEDIATR PSYCHOL, V33, P380, DOI 10.1093/jpepsy/jsn005
Mindell JA, 2008, ANN ACAD MED SINGAP, V37, P722
Mindell JA, 2006, SLEEP, V29, P1263
Minjarez MB, 2011, J AUTISM DEV DISORD, V41, P92, DOI 10.1007/s10803-010-1027-6
Miodrag N, 2010, CURR OPIN PSYCHIATR, V23, P407, DOI 10.1097/YCO.0b013e32833a8796
Montgomery P, 2004, ARCH DIS CHILD, V89, P125, DOI 10.1136/adc.2002.017202
Moore P. S., 2004, BRIT J LEARN DISABIL, V32, P133, DOI 10.1111/j.1468-3156.2004.00278.x
O'Connell A., 2005, SLEEPWISE POSITIVE S
O'Connell A, 2008, AUST OCCUP THER J, V55, P212, DOI 10.1111/j.1440-1630.2007.00717.x
Owens JA, 2000, SLEEP, V23, P1043
Oyane NMF, 2005, AUTISM, V9, P83, DOI 10.1177/1362361305049031
Reed HE, 2009, J CHILD NEUROL, V24, P936, DOI 10.1177/0883073808331348
Reitman D, 2002, J CLIN CHILD ADOLESC, V31, P384, DOI 10.1207/153744202760082649
Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
Sadeh A, 2008, J PEDIATR PSYCHOL, V33, P406, DOI 10.1093/jpepsy/jsn018
Schlarb Angelika A, 2011, Nat Sci Sleep, V3, P13, DOI 10.2147/NSS.S14493
Schlarb Angelika A, 2011, Nat Sci Sleep, V3, P1, DOI 10.2147/NSS.S15254
Spiegel K, 2009, NAT REV ENDOCRINOL, V5, P253, DOI 10.1038/nrendo.2009.23
Stores R, 2004, J APPL RES INTELLECT, V17, P61, DOI 10.1111/j.1360-2322.2004.00174.x
Tietze AL, 2012, SLEEP MED REV, V16, P117, DOI 10.1016/j.smrv.2011.03.006
Turner KS, 2013, TOP EARLY CHILD SPEC, V33, P144, DOI 10.1177/0271121412446204
Van Cauter E, 2008, EUR J ENDOCRINOL, V159, pS59, DOI 10.1530/EJE-08-0298
Vriend JL, 2011, J PEDIATR PSYCHOL, V36, P1017, DOI 10.1093/jpepsy/jsr044
Wiggs L, 2004, DEV MED CHILD NEUROL, V46, P372
Wiggs L., 2005, INT J BEHAV CONSULT, V1, P165
Williams J, 2010, DEV MED CHILD NEUROL, V52, P227, DOI 10.1111/j.1469-8749.2010.03622.x
Williams PG, 2004, J SLEEP RES, V13, P265
NR 78
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1695
EP 1707
DI 10.1007/s10803-014-2040-y
PG 13
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800018
PM 24442795
ER
PT J
AU Zuckerman, KE
Hill, AP
Guion, K
Voltolina, L
Fombonne, E
AF Zuckerman, Katharine E.
Hill, Alison P.
Guion, Kimberly
Voltolina, Lisa
Fombonne, Eric
TI Overweight and Obesity: Prevalence and Correlates in a Large Clinical
Sample of Children with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Obesity; Overweight; Children
ID BODY-MASS INDEX; SCHOOL-AGED CHILDREN; CHILDHOOD OBESITY; SLEEP
PROBLEMS; RISK-FACTORS; ADOLESCENTS; POPULATION; MORTALITY; DEPRESSION;
WEIGHT
AB Autism Spectrum Disorders (ASDs) and childhood obesity (OBY) are rising public health concerns. This study aimed to evaluate the prevalence of overweight (OWT) and OBY in a sample of 376 Oregon children with ASD, and to assess correlates of OWT and OBY in this sample. We used descriptive statistics, bivariate, and focused multivariate analyses to determine whether socio-demographic characteristics, ASD symptoms, ASD cognitive and adaptive functioning, behavioral problems, and treatments for ASD were associated with OWT and OBY in ASD. Overall 18.1 % of children met criteria for OWT and 17.0 % met criteria for OBY. OBY was associated with sleep difficulties, melatonin use, and affective problems. Interventions that consider unique needs of children with ASD may hold promise for improving weight status among children with ASD.
C1 [Zuckerman, Katharine E.] Oregon Hlth & Sci Univ, Div Gen Pediat, Portland, OR 97239 USA.
[Zuckerman, Katharine E.] Oregon Hlth & Sci Univ, Child & Adolescent Hlth Measurement Initiat, Dept Pediat, Portland, OR 97239 USA.
[Hill, Alison P.] Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, Portland, OR 97239 USA.
[Hill, Alison P.; Guion, Kimberly; Voltolina, Lisa; Fombonne, Eric] Oregon Hlth & Sci Univ, Inst Dev & Disabil, Portland, OR 97239 USA.
[Guion, Kimberly] Oregon Hlth & Sci Univ, Div Child Psychol, Portland, OR 97239 USA.
[Voltolina, Lisa] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA.
RP Zuckerman, KE (reprint author), Oregon Hlth & Sci Univ, Div Gen Pediat, 707 SW Gaines Rd,Mail Code CDRC P, Portland, OR 97239 USA.
EM zuckerma@ohsu.edu
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Bethell C, 2010, HEALTH AFFAIR, V29, P347, DOI 10.1377/hlthaff.2009.0762
Bixler EO, 2009, SLEEP, V32, P731
Bjorge T, 2008, AM J EPIDEMIOL, V168, P30, DOI 10.1093/aje/kwn096
Blumberg S. J., 2013, CHANGES PARENT REPOR
Chen AY, 2010, OBESITY, V18, P210, DOI 10.1038/oby.2009.185
Curtin Carol, 2005, BMC Pediatr, V5, P48, DOI 10.1186/1471-2431-5-48
Curtin C, 2010, BMC PEDIATR, V10, DOI 10.1186/1471-2431-10-11
de Vinck-Baroody O., 2013, PED AC SOC C WASH DC
Dev DA, 2013, CHILD OBES, V9, P399, DOI 10.1089/chi.2012.0150
Dietz WH, 2005, NEW ENGL J MED, V352, P2100, DOI 10.1056/NEJMcp043052
Dreyer M., 2008, OBESITY, V16, P284
Egan AM, 2013, CHILD OBES, V9, P125, DOI 10.1089/chi.2012.0028
Evans EW, 2012, RES AUTISM SPECT DIS, V6, P399, DOI 10.1016/j.rasd.2011.06.014
Faraone SV, 2008, J AM ACAD CHILD PSY, V47, P994, DOI 10.1097/CHI.ObO13e31817eOea7
Fishman L, 2004, J PEDIATR-US, V145, P253, DOI 10.1016/j.jpeds.2004.04.022
Friedemann C, 2012, BRIT MED J, V345, DOI 10.1136/bmj.e4759
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
Goodman E, 2002, PEDIATRICS, V110, P497, DOI 10.1542/peds.110.3.497
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Hellings JA, 2001, J CHILD ADOL PSYCHOP, V11, P229, DOI 10.1089/10445460152595559
Ho H. H., 1997, FOCUS AUTISM OTHER D, V12, P187
Hus V, 2014, J AUTISM DEV DISORD, V44, P2400, DOI 10.1007/s10803-012-1719-1
Hyman Susan L, 2012, Pediatrics, V130 Suppl 2, pS145, DOI 10.1542/peds.2012-0900L
Katz T. F., 2013, INT M AUST RES SAN S
Kipping RR, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a1824
Krebs NF, 2007, PEDIATRICS, V120, pS193, DOI 10.1542/peds.2007-2329D
Kuczmarski RJ, 2000, ADV DATA, V314, P1
Lee LC, 2008, J AUTISM DEV DISORD, V38, P1147, DOI 10.1007/s10803-007-0491-0
Lord C., 1999, AUTISM DIAGNOSTIC OB
Maenner MJ, 2010, PEDIATRICS, V126, pE1018, DOI 10.1542/peds.2010-1023
Miller D. T., 2009, 16P11 2 MICRODELETIO
Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
Minihan PM, 2007, J LAW MED ETHICS, V35, P61, DOI 10.1111/j.1748-720X.2007.00113.x
Mullen E, 1995, MULLEN SCALES EARLY
Must A, 2012, J PEDIATR-US, V160, P743, DOI 10.1016/j.jpeds.2011.10.037
Ogden CL, 2002, JAMA-J AM MED ASSOC, V288, P1728, DOI 10.1001/jama.2012.40
Owens JA, 2000, SLEEP, V23, P1043
PinhasHamiel O, 1996, J PEDIATR-US, V128, P608, DOI 10.1016/S0022-3476(96)80124-7
Reynolds AM, 2011, PEDIATR CLIN N AM, V58, P685, DOI 10.1016/j.pcl.2011.03.009
Richdale AL, 1999, DEV MED CHILD NEUROL, V41, P60, DOI 10.1017/S0012162299000122
Rimmer JH, 2010, J INTELL DISABIL RES, V54, P787, DOI 10.1111/j.1365-2788.2010.01305.x
Roid G. H., 2003, STANFORD BINET INTEL
Schreck KA, 2004, RES DEV DISABIL, V25, P57, DOI 10.1016/j.ridd.2003.04.007
Sjoberg RL, 2005, PEDIATRICS, V116, pE389, DOI 10.1542/peds.2005-0170
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Taylor ED, 2006, PEDIATRICS, V117, P2167, DOI 10.1542/peds.2005-1832
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
UNGER R, 1990, CLIN PEDIATR, V29, P368, DOI 10.1177/000992289002900701
van Dam RM, 2006, ANN INTERN MED, V145, P91
Verhulst SL, 2007, ARCH DIS CHILD, V92, P205, DOI 10.1136/adc.2006.101089
Wardle J, 2005, BEST PRACT RES CL EN, V19, P421, DOI 10.1016/j.beem.2005.04.006
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
WILLIAMS DP, 1992, AM J PUBLIC HEALTH, V82, P358, DOI 10.2105/AJPH.82.3.358
Windham GC, 2011, J AUTISM DEV DISORD, V41, P1362, DOI 10.1007/s10803-010-1160-2
Zimmer MH, 2012, J AUTISM DEV DISORD, V42, P549, DOI 10.1007/s10803-011-1268-z
NR 57
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1708
EP 1719
DI 10.1007/s10803-014-2050-9
PG 12
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800019
PM 24488158
ER
PT J
AU Siller, M
Swanson, M
Gerber, A
Hutman, T
Sigman, M
AF Siller, Michael
Swanson, Meghan
Gerber, Alan
Hutman, Ted
Sigman, Marian
TI A Parent-Mediated Intervention That Targets Responsive Parental
Behaviors Increases Attachment Behaviors in Children with ASD: Results
from a Randomized Clinical Trial
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Randomized clinical trial; Parent child communication;
Attachment; Intervention
ID AUTISM SPECTRUM DISORDER; AT-RISK MOTHERS; JOINT ATTENTION;
DEVELOPMENTAL DISORDERS; IRRITABLE INFANTS; YOUNG-CHILDREN;
DOWN-SYNDROME; MISSING DATA; COMMUNICATION; LANGUAGE
AB The current study is a randomized clinical trial evaluating the efficacy of Focused Playtime Intervention (FPI) in a sample of 70 children with Autism Spectrum Disorder. This parent-mediated intervention has previously been shown to significantly increase responsive parental communication (Siller et al. in J Autism Dev Disord 43:540-555, 2013a). The current analyses focus on children's attachment related outcomes. Results revealed that children who were randomly assigned to FPI showed bigger increases in attachment-related behaviors, compared to children assigned to the control condition. Significant treatment effects of FPI were found for both an observational measure of attachment-related behaviors elicited during a brief separation-reunion episode and a questionnaire measure evaluating parental perceptions of child attachment. The theoretical and clinical implications of these findings are discussed.
C1 [Siller, Michael; Hutman, Ted; Sigman, Marian] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
[Siller, Michael; Swanson, Meghan; Gerber, Alan] CUNY, Hunter Coll, Dept Psychol, New York, NY 10065 USA.
RP Siller, M (reprint author), CUNY, Hunter Coll, Dept Psychol, RM 611 HN,695 Pk Ave, New York, NY 10065 USA.
EM msiller@hunter.cuny.edu
CR Ainsworth M. S., 1978, PATTERNS ATTACHMENT
AINSWORTH MDS, 1979, AM PSYCHOL, V34, P932, DOI 10.1037//0003-066X.34.10.932
Atkinson L, 1999, MONOGR SOC RES CHILD, V64, P45, DOI 10.1111/1540-5834.00033
Bernabei P., 1998, AUTISM, V2, P243, DOI 10.1177/1362361398023003
Bono MA, 2004, J AUTISM DEV DISORD, V34, P495, DOI 10.1007/s10803-004-2545-x
Bowlby J., 1969, ATTACHMENT LOSS, V1
CAPPS L, 1994, DEV PSYCHOPATHOL, V6, P249, DOI 10.1017/S0954579400004569
Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
Cassidy J, 1999, HDB ATTACHMENT THEOR
Claussen AH, 2002, DEV PSYCHOPATHOL, V14, P279
Collins LM, 2001, PSYCHOL METHODS, V6, P330, DOI 10.1037//1082-989X.6.4.330
DeWolff MS, 1997, CHILD DEV, V68, P571, DOI 10.2307/1132107
Duncan GJ, 2003, CHILD DEV, V74, P1454
Enders CK, 2010, APPL MISSING DATA AN
Fitzmaurice GM, 2004, APPL LONGITUDINAL AN
Goodman SJ, 2012, J AUTISM DEV DISORD, V42, P2056, DOI 10.1007/s10803-012-1453-8
Graham J. W., 2007, PREVENTATIVE SCI, V8, P208, DOI DOI 10.1007/S11121-007-0070-9
Heinicke CM, 1999, INF MENTAL HLTH J, V20, P349, DOI 10.1002/(SICI)1097-0355(199924)20:4<349::AID-IMHJ1>3.0.CO;2-X
Heinicke CM, 2001, INF MENTAL HLTH J, V22, P431, DOI 10.1002/imhj.1010
HOPPES K, 1990, J CLIN CHILD PSYCHOL, V19, P365, DOI 10.1207/s15374424jccp1904_8
Juffer F., 2008, PROMOTING POSITIVE P
Koren-Karie N, 2009, J CHILD PSYCHOL PSYC, V50, P643, DOI 10.1111/j.1469-7610.2008.02043.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mullen E, 1995, MULLEN SCALES EARLY
Naber FBA, 2007, J ABNORM CHILD PSYCH, V35, P899, DOI 10.1007/s10802-007-9142-3
Naber FBA, 2007, J AUTISM DEV DISORD, V37, P1123, DOI 10.1007/s10803-006-0255-2
Powell B., 2007, ATTACHMENT THEORY CL, P172
ROGERS SJ, 1991, J AM ACAD CHILD PSY, V30, P483, DOI 10.1097/00004583-199105000-00021
Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
Seibert J. M., 1982, INFANT MENT HEALTH J, V3, P244, DOI DOI 10.1002/1097-0355(198224)3:4<244::AID-IMHJ2280030406>3.0.CO;2-R
SIGMAN M, 1989, J AM ACAD CHILD PSY, V28, P74, DOI 10.1097/00004583-198901000-00014
Siller M, 2013, J AUTISM DEV DISORD, V43, P540, DOI 10.1007/s10803-012-1584-y
Siller M, 2014, AUTISM, V18, P433, DOI 10.1177/1362361313476766
Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
Siller M., 2006, NATURE INDIVID UNPUB
Sroufe LA, 2010, DEV REV, V30, P36, DOI 10.1016/j.dr.2009.12.002
vandenBoom DC, 1995, CHILD DEV, V66, P1798, DOI 10.2307/1131911
VANDENBOOM DC, 1994, CHILD DEV, V65, P1457, DOI 10.2307/1131511
van IJzendoorn MH, 2007, CHILD DEV, V78, P597, DOI 10.1111/j.1467-8624.2007.01016.x
VAN IJZENDOORN MH, 1995, SOC DEV, V4, P115
Woods JJ, 2011, TOP LANG DISORD, V31, P235, DOI 10.1097/TLD.0b013e318227fde4
NR 44
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1720
EP 1732
DI 10.1007/s10803-014-2049-2
PG 13
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800020
PM 24488157
ER
PT J
AU Bauminger-Zviely, N
Agam-Ben-Artzi, G
AF Bauminger-Zviely, Nirit
Agam-Ben-Artzi, Galit
TI Young Friendship in HFASD and Typical Development: Friend Versus
Non-friend Comparisons
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE High-functioning children with autism spectrum disorder (ASD);
Preschool; Friendship; Dyads; Peer relations; Peer interaction
ID HIGH-FUNCTIONING CHILDREN; AUTISM SPECTRUM DISORDER; ASPERGER-SYNDROME;
PEER INTERACTION; SCHOOL; ADOLESCENTS; BEHAVIOR; BOYS; LONELINESS;
ADJUSTMENT
AB This study conducted comparative assessment of friendship in preschoolers with high-functioning autism spectrum disorder (HFASD, n = 29) versus preschoolers with typical development (n = 30), focusing on interactions with friends versus acquaintances. Groups were matched on SES, verbal/nonverbal MA, IQ, and CA. Multidimensional assessments included: mothers' and teachers' reports about friends' and friendship characteristics and observed individual and dyadic behaviors throughout interactions with friends versus non-friends during construction, drawing, and free-play situations. Findings revealed group differences in peer interaction favoring the typical development group, thus supporting the neuropsychological profile of HFASD. However, both groups' interactions with friends surpassed interactions with acquaintances on several key socio-communicative and intersubjective capabilities, thus suggesting that friendship may contribute to enhancement and practice of social interaction in HFASD.
C1 [Bauminger-Zviely, Nirit; Agam-Ben-Artzi, Galit] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
RP Bauminger-Zviely, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM nirit.bauminger@biu.ac.il
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4
Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
Baron-Cohen S, 2003, J AUTISM DEV DISORD, V33, P509, DOI 10.1023/A:1025879411971
Barry CM, 2006, DEV PSYCHOL, V42, P153, DOI 10.1037/0012-1649.42.1.153
Bauminger N, 2008, J AUTISM DEV DISORD, V38, P1211, DOI 10.1007/s10803-007-0501-2
Bauminger N, 2008, J ABNORM CHILD PSYCH, V36, P135, DOI 10.1007/s10802-007-9156-x
Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
Bauminger N, 2003, AUTISM, V7, P81, DOI 10.1177/1362361303007001007
Bauminger N., 2005, FRIENDSHIP OBS UNPUB
BRACHFELD-CHILD S, 1990, Journal of Genetic Psychology, V151, P45
Buysse V., 1991, EARLY CHILDHOOD FRIE
Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Chamberlain B, 2007, J AUTISM DEV DISORD, V37, P230, DOI 10.1007/s10803-006-0164-4
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
Daniel LS, 2010, FOCUS AUTISM DEV DIS, V25, P220, DOI 10.1177/1088357610378290
Dunn J, 2002, CHILD DEV, V73, P621, DOI 10.1111/1467-8624.00427
Dunn J., 2004, CHILDRENS FRIENDSHIP
Dunn J, 1999, SOC DEV, V8, P201, DOI 10.1111/1467-9507.00091
Dunn J., 1993, YOUNG CHILDRENS CLOS
Embregts P, 2009, J INTELL DISABIL RES, V53, P922, DOI 10.1111/j.1365-2788.2009.01204.x
Engle JM, 2011, INFANT CHILD DEV, V20, P365, DOI 10.1002/icd.706
FIELD T, 1992, DEV PSYCHOL, V28, P242, DOI 10.1037//0012-1649.28.2.242
FOOT HC, 1977, J PERS SOC PSYCHOL, V35, P401, DOI 10.1037//0022-3514.35.6.401
HARTUP WW, 1988, CHILD DEV, V59, P1590, DOI 10.1111/j.1467-8624.1988.tb03686.x
Hobson P., 2005, HDB AUTISM PERVASIVE, P406
HOWES C, 1994, J SOC PERS RELAT, V11, P401, DOI 10.1177/0265407594113006
Howes C., 1992, COLLABORATIVE CONSTR
HOWES C, 1983, CHILD DEV, V54, P1041, DOI 10.1111/j.1467-8624.1983.tb00525.x
Howes C., 1996, CO THEY KEEP FRIENDS, P66
Howes C., 2009, HDB PEER INTERACTION, P180
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Humphrey N, 2011, AUTISM, V15, P397, DOI 10.1177/1362361310387804
Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
Jones CD, 2009, J AUTISM DEV DISORD, V39, P432, DOI 10.1007/s10803-008-0642-y
Kanner L, 1943, NERV CHILD, V2, P217
Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
Koning C, 2001, AUTISM, V5, P23, DOI 10.1177/1362361301005001003
Ladd GW, 1996, CHILD DEV, V67, P1103, DOI 10.1111/j.1467-8624.1996.tb01785.x
Lemerise EA, 2000, CHILD DEV, V71, P107, DOI 10.1111/1467-8624.00124
Locke J., 2010, J RES SPECIAL ED NEE, V10, P74, DOI DOI 10.1111/J.1471-3802.2010.01148.X
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1995, DEV PSYCHOPATHOL, V7, P611
Macintosh Kathleen, 2006, Autism, V10, P199, DOI 10.1177/1362361306062026
Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
Mullen E, 1995, MULLEN SCALES EARLY
Myers BJ, 2013, MONOGR SOC RES CHILD, V78, P26, DOI 10.1111/mono.12019
Nadig A, 2010, NEUROPSYCHOLOGIA, V48, P2730, DOI 10.1016/j.neuropsychologia.2010.05.020
NEWCOMB AF, 1995, PSYCHOL BULL, V117, P306, DOI 10.1037//0033-2909.117.2.306
NEWCOMB AF, 1982, CHILD DEV, V53, P392, DOI 10.1111/j.1467-8624.1982.tb01328.x
Orsmond G. I., 2011, AUTISM, V15, P1
Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
Pedersen S, 2007, CHILD DEV, V78, P1037, DOI 10.1111/j.1467-8624.2007.01051.x
Rogers J. S., 1991, DEV PSYCHOPATHOL, V3, P137
Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
Siperstein GN, 1997, AM J MENT RETARD, V102, P111, DOI 10.1352/0895-8017(1997)102<0111:TQOFBC>2.0.CO;2
Solish A, 2010, J APPL RES INTELLECT, V23, P226, DOI 10.1111/j.1468-3148.2009.00525.x
Stern D., 1985, INTERPERSONAL WORLD
Szatmari P., 2011, AUTISM SPECTRUM DISO, P330
Tager-Flusberg H, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P173
Vitaro F., 2009, HDB PEER INTERACTION, P568
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
Wechsler D., 1998, WECHSLER SCALES INTE
NR 67
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1733
EP 1748
DI 10.1007/s10803-014-2052-7
PG 16
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800021
PM 24488120
ER
PT J
AU Deschamps, PKH
Been, M
Matthys, W
AF Deschamps, Peter K. H.
Been, Marieke
Matthys, Walter
TI Empathy and Empathy Induced Prosocial Behavior in 6-and 7-Year-Olds with
Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Children; Cognitive empathy; Affective
empathy; Empathy induced prosocial behavior
ID HIGH-FUNCTIONING AUTISM; EMOTION RECOGNITION; ASPERGER-SYNDROME; COMPLEX
EMOTION; FUTURE-RESEARCH; FILMS TASK; CHILDREN; INDIVIDUALS; ADULTS;
MIND
AB The present study aimed to assess empathy and prosocial behavior in 6-7 year old children with autism spectrum disorders (ASDs). Results showed, first, lower levels of parent- and teacher-rated cognitive empathy, and similar levels of affective empathy in children with ASD compared to typically developing (TD) children. Second, emotion recognition for basic emotions, one aspect of cognitive empathy, in a story task was adequate in ASD children, but ASD children with severe impairments in social responsiveness had difficulties in recognizing fear. Third, prosocial behavior in response to signals of distress of a peer in a computer task was similar in ASD as in TD children. In conclusion, early elementary school children with ASD show specific impairments in cognitive empathy.
C1 [Deschamps, Peter K. H.; Been, Marieke; Matthys, Walter] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, NL-3508 GA Utrecht, Netherlands.
[Matthys, Walter] Univ Utrecht, Dept Child & Adolescent Studies, Utrecht, Netherlands.
RP Deschamps, PKH (reprint author), Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, HP A01-468,Postbus 85500, NL-3508 GA Utrecht, Netherlands.
EM p.k.h.deschamps@umcutrecht.nl
CR Albiero P., 2001, CONSTRUCTIVE DESTRUC, P205, DOI 10.1037/10433-010
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Auyeung B, 2012, J AUTISM DEV DISORD, V42, P2225, DOI 10.1007/s10803-012-1454-7
Barnes JL, 2009, AUTISM RES, V2, P148, DOI 10.1002/aur.79
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Bolte S, 2003, PSYCHOL MED, V33, P907, DOI 10.1017/S0033291703007438
Bons D, 2013, J ABNORM CHILD PSYCH, V41, P425, DOI 10.1007/s10802-012-9689-5
BRYANT BK, 1982, CHILD DEV, V53, P413, DOI 10.1111/j.1467-8624.1982.tb01331.x
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2005, SOCIAL RESPONSIVENES
Dadds M. R., 2004, INTERPERSONAL REPONS
Dadds MR, 2008, CHILD PSYCHIAT HUM D, V39, P111, DOI 10.1007/s10578-007-0075-4
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Deschamps PKH, 2015, J AUTISM DEV DISORD, V45, P354, DOI 10.1007/s10803-013-1890-z
de Waal FBM, 2010, PHILOS T R SOC B, V365, P2711, DOI 10.1098/rstb.2010.0119
Eisenberg N, 2010, SOC ISS POLICY REV, V4, P143, DOI 10.1111/j.17512409.2010.01020.x
Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
FESHBACH ND, 1968, CHILD DEV, V39, P133, DOI 10.1111/j.1467-8624.1968.tb04412.x
Frankel FD, 2011, J CHILD PSYCHOL PSYC, V52, P571, DOI 10.1111/j.1469-7610.2010.02318.x
Gaigg Sebastian B, 2012, Front Integr Neurosci, V6, P113, DOI 10.3389/fnint.2012.00113
Golan O, 2006, SOC NEUROSCI-UK, V1, P111, DOI 10.1080/17470910600980986
Golan O, 2008, J AUTISM DEV DISORD, V38, P1534, DOI 10.1007/s10803-007-0533-7
Greimel E, 2011, Z KINDER JUG-PSYCH, V39, P113, DOI 10.1024/1422-4917/a000097
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Hu VW, 2009, AUTISM RES, V2, P67, DOI 10.1002/aur.72
Humphreys K, 2007, NEUROPSYCHOLOGIA, V45, P685, DOI 10.1016/j.neuropsychologia.2006.08.003
Iizuka C, 2010, BRAIN DEV-JPN, V32, P609, DOI 10.1016/j.braindev.2009.09.009
Johnson SA, 2009, J AUTISM DEV DISORD, V39, P1706, DOI 10.1007/s10803-009-0809-1
Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x
Jones AP, 2010, J AUTISM DEV DISORD, V40, P1094, DOI 10.1007/s10803-010-0957-3
Kort W., 2005, WECHSLER INTELLIGENC
Liebal K, 2008, J AUTISM DEV DISORD, V38, P224, DOI 10.1007/s10803-007-0381-5
Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
McDonald NM, 2012, J AUTISM DEV DISORD, V42, P1566, DOI 10.1007/s10803-011-1390-y
Murray MJ, 2011, J AUTISM DEV DISORD, V41, P1586, DOI 10.1007/s10803-011-1178-0
Piggot J, 2004, J AM ACAD CHILD PSY, V43, P473, DOI 10.1097/01.chi.0000111363.94169.37
Pouw LBC, 2013, RES DEV DISABIL, V34, P1256, DOI 10.1016/j.ridd.2012.12.022
Roeyers H., 2012, SCHITTEKATTE M NEDER
Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
Russell G, 2012, J CHILD PSYCHOL PSYC, V53, P735, DOI 10.1111/j.1469-7610.2011.02490.x
Sattler J.M., 1992, ASSESSMENT CHILDREN
Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x
Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
Travis L, 2001, J AUTISM DEV DISORD, V31, P119, DOI 10.1023/A:1010705912731
Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
NR 49
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1749
EP 1758
DI 10.1007/s10803-014-2048-3
PG 10
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800022
PM 24488118
ER
PT J
AU Schwartz, C
Dratsch, T
Vogeley, K
Bente, G
AF Schwartz, Caroline
Dratsch, Thomas
Vogeley, Kai
Bente, Gary
TI Brief Report: Impression Formation in High-Functioning Autism: Role of
Nonverbal Behavior and Stereotype Activating Information
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE High-functioning autism (HFA); Impression formation; Nonverbal behavior;
Stereotype; Virtual characters
ID ASPERGER-SYNDROME; PERCEPTION
AB Little is known about whether stereotypes influence social judgments of autistic individuals, in particular when they compete with tacit face-to-face cues. We compared impression formation of 17 subjects with high-functioning autism (HFA) and 17 age-, gender- and IQ-matched controls. Information about the profession of a job applicant served as stereotype activating information. The target person's nonverbal behavior was presented as a computer animation showing two virtual characters in interaction. Contrary to our hypothesis, HFA participants were as sensitive to nonverbal cues as controls. Moreover, HFA showed a tendency to evaluate persons more positively. This might indicate a routine HFA apply in impression formation in order to compensate for their deficit in intuitive understanding of nonverbal communication cues.
C1 [Schwartz, Caroline; Dratsch, Thomas; Bente, Gary] Univ Cologne, Dept Social Psychol, D-50931 Cologne, Germany.
[Schwartz, Caroline] Klinikum Univ Munchen, Klin Psychiat & Psychotherapie, D-80336 Munich, Germany.
[Vogeley, Kai] Univ Hosp Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany.
[Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med, Julich, Germany.
RP Schwartz, C (reprint author), Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
EM caroline.schwartz@gmx.de
CR ASCH SE, 1946, J ABNORM SOC PSYCH, V41, P258, DOI 10.1037/h0055756
BANAJI MR, 1993, J PERS SOC PSYCHOL, V65, P272, DOI 10.1037/0022-3514.65.2.272
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Bente G, 2010, CONSCIOUS COGN, V19, P762, DOI 10.1016/j.concog.2010.06.006
Bente G, 2001, J NONVERBAL BEHAV, V25, P151, DOI 10.1023/A:1010690525717
DePaulo B. M., 1998, HDB SOCIAL PSYCHOL, V2, P3
Georgescu AL, 2014, HUM BRAIN MAPP, V35, P1362, DOI 10.1002/hbm.22259
Heavey L, 2000, J AUTISM DEV DISORD, V30, P225, DOI 10.1023/A:1005544518785
Hirschfeld L., 2007, CURR BIOL, V17, P451
KUNDA Z, 1993, PERS SOC PSYCHOL B, V19, P90, DOI 10.1177/0146167293191010
Kuzmanovic B, 2011, RES AUTISM SPECT DIS, V5, P604, DOI 10.1016/j.rasd.2010.07.005
Kuzmanovic B, 2012, NEUROIMAGE, V60, P179, DOI 10.1016/j.neuroimage.2011.12.046
Morsanyi K, 2010, J AUTISM DEV DISORD, V40, P1378, DOI 10.1007/s10803-010-0993-z
Nackaerts E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044473
OSGOOD CE, 1966, SCAND J PSYCHOL, V7, P1, DOI 10.1111/j.1467-9450.1966.tb01334.x
Saygin AP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013491
Schwartz C, 2010, J AUTISM DEV DISORD, V40, P100, DOI 10.1007/s10803-009-0843-z
Tewes U., 1991, HAMBURG WECHSLER INT
Uleman JS, 1996, ADV EXP SOC PSYCHOL, V28, P211, DOI 10.1016/S0065-2601(08)60239-7
White S, 2006, BRAIN COGNITION, V61, P69, DOI 10.1016/j.bande.2005.12.007
NR 22
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1759
EP 1765
DI 10.1007/s10803-013-2021-6
PG 7
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800023
PM 24362848
ER
PT J
AU Samson, AC
Phillips, JM
Parker, KJ
Shah, S
Gross, JJ
Hardan, AY
AF Samson, Andrea C.
Phillips, Jennifer M.
Parker, Karen J.
Shah, Shweta
Gross, James J.
Hardan, Antonio Y.
TI Emotion Dysregulation and the Core Features of Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Core features; Emotion regulation;
Restricted/repetitive behaviors; Social/communication deficits; Sensory
abnormalities
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC
INTERVIEW; REPETITIVE BEHAVIOR; ASPERGERS SYNDROME; SENSORY PROFILE;
YOUNG-PEOPLE; CHILDREN; COMMUNICATION; INDIVIDUALS
AB The aim of this study was to examine the relationship between emotion dysregulation and the core features of Autism Spectrum Disorder (ASD), which include social/communication deficits, restricted/repetitive behaviors, and sensory abnormalities. An 18-item Emotion Dysregulation Index was developed on the basis of expert ratings of the Child Behavior Checklist. Compared to typically developing controls, children and adolescents with ASD showed more emotion dysregulation and had significantly greater symptom severity on all scales. Within ASD participants, emotion dysregulation was related to all core features of the disorder, but the strongest association was with repetitive behaviors. These findings may facilitate the development of more effective therapeutic strategies targeting emotion dysregulation in order to optimize long-term outcomes for individuals with ASD.
C1 [Samson, Andrea C.; Shah, Shweta; Gross, James J.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
[Phillips, Jennifer M.; Parker, Karen J.; Hardan, Antonio Y.] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA.
RP Samson, AC (reprint author), Stanford Univ, Dept Psychol, 450 Serra Mall,Bldg 420, Stanford, CA 94305 USA.
EM andrea.samson@stanford.edu
CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
Cole PM, 2004, CHILD DEV, V75, P317, DOI 10.1111/j.1467-8624.2004.00673.x
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Constantino JN, 2005, SOCIAL RESPONSIVENES
Geller L., 2005, AUTISM SPECTRUM Q, P14, DOI [10.1037/a0027975, DOI 10.1037/A0027975]
Goldin PR, 2008, BIOL PSYCHIAT, V63, P577, DOI 10.1016/j.biopsych.2007.05.031
Jahromi LB, 2012, J CHILD PSYCHOL PSYC, V53, P1250, DOI 10.1111/j.1469-7610.2012.02560.x
Jahromi LB, 2013, RES AUTISM SPECT DIS, V7, P235, DOI 10.1016/j.rasd.2012.08.012
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
Kientz MA, 1997, AM J OCCUP THER, V51, P530
Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4
Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
Laurent AC, 2004, TOP LANG DISORD, V24, P286
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mazefsky CA, 2012, CHILD DEV PERSPECT, V6, P92, DOI 10.1111/j.1750-8606.2011.00229.x
McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
Ochsner KN, 2008, CURR DIR PSYCHOL SCI, V17, P153, DOI 10.1111/j.1467-8721.2008.00566.x
Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
Prizant B. M., 2011, AUTISM SPECTRUM Q, V1, P29
Prizant BM, 2003, INFANT YOUNG CHILD, V16, P296
Quek LH, 2012, J CLIN PSYCHOL, V68, P1142, DOI 10.1002/jclp.21888
Roid GH, 2003, STANFORD BINETS INTE
Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975
Scarpa A, 2011, BEHAV COGN PSYCHOTH, V39, P495, DOI 10.1017/S1352465811000063
Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
NR 34
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1766
EP 1772
DI 10.1007/s10803-013-2022-5
PG 7
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800024
PM 24362795
ER
PT J
AU Choque Olsson, N
Bolte, S
AF Choque Olsson, Nora
Bolte, Sven
TI Brief Report: "Quick and (not so) Dirty" Assessment of Change in Autism:
Cross-Cultural Reliability of the Developmental Disabilities CGAS and
the OSU Autism CGI
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Intervention; Outcome; Longitudinal; Asperger syndrome; Psychometrics
ID GLOBAL ASSESSMENT SCALE; SOCIAL RESPONSIVENESS SCALE; STANDARDIZED ADOS
SCORES; SPECTRUM DISORDERS; SEVERITY; SRS; CHILDREN; ADULTS
AB There are few evaluated economic tools to assess change in autism. This study examined the inter-rater reliability of the Developmental Disabilities Children's Global Assessment Scale (DD-CGAS), and the OSU Autism Clinical Global Impression (OSU Autism CGI) in a European setting. Using these scales, 16 clinicians with multidisciplinary background and varying experience independently rated eight vignettes of autism spectrum disorder for severity and general psychosocial functioning at referral and discharge. Intraclass correlation coefficient (ICCs) for experienced clinicians were .75 for the DD-CGAS and .72 for the OSU Autism CGI. In inexperienced clinicians these ICCs were .58 and .59. Results confirm previous North American studies, and further extents the reliability of the instruments to untrained, less experienced clinicians with different professions.
C1 [Choque Olsson, Nora; Bolte, Sven] Karolinska Inst, Ctr Neurodev Disorders KIND, Pediat Neuropsychiat Unit, Dept Womens & Childrens Hlth,CAP Res Ctr, S-11330 Stockholm, Sweden.
[Choque Olsson, Nora; Bolte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden.
RP Bolte, S (reprint author), Karolinska Inst, Ctr Neurodev Disorders KIND, Pediat Neuropsychiat Unit, Dept Womens & Childrens Hlth,CAP Res Ctr, Gavlegatan 22, S-11330 Stockholm, Sweden.
EM nora.choque-olsson@ki.se; sven.bolte@ki.se
CR Abel KM, 2013, AM J PSYCHIAT, V170, P391, DOI 10.1176/appi.ajp.2012.12040543
American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
Arnold LE, 2000, J AUTISM DEV DISORD, V30, P99, DOI 10.1023/A:1005451304303
Bolte S, 2008, AUTISM RES, V1, P354, DOI 10.1002/aur.49
Bolte S, 2012, J AUTISM DEV DISORD, V42, P1998, DOI 10.1007/s10803-011-1424-5
Charman T, 2013, CHILD ADOL MENT H-UK, V18, P52, DOI 10.1111/j.1475-3588.2012.00664.x
Constantino J. N., 2012, SOCIAL RESPONSIVENES, Vsecond
Constantino JN, 2013, J CHILD PSYCHOL PSYC, V54, P695, DOI 10.1111/jcpp.12064
de Bildt A, 2011, J AUTISM DEV DISORD, V41, P311, DOI 10.1007/s10803-010-1057-0
Dyrborg J, 2000, EUR CHILD ADOLES PSY, V9, P195
Gotham K, 2012, PEDIATRICS, V130, pE1278, DOI 10.1542/peds.2011-3668
Guy W, 1976, ECDEU ASSESSMENT MAN, P218
Howlin P, 2012, CAN J PSYCHIAT, V57, P275
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
Lord C, 2012, J CONSULT CLIN PSYCH, V80, P477, DOI 10.1037/a0027214
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2013, ED S INT M AUT RES S
Lundh A, 2010, PSYCHIAT RES, V177, P206, DOI 10.1016/j.psychres.2010.02.006
Lundh A, 2012, ADM POLICY MENT HLTH, V39, P458, DOI 10.1007/s10488-011-0369-5
Magnusson PKE, 2013, TWIN RES HUM GENET, V16, P317, DOI 10.1017/thg.2012.104
Oono IP, 2013, COCHRANE DB SYST REV, V4
Reichow B, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008511.pub2
Rutter M., 2003, AUTISM DIAGNOSTIC IN
SHAFFER D, 1983, ARCH GEN PSYCHIAT, V40, P1228
The OSU Research Unit on Pediatric Psychopharmacology, 2005, OSU AUT RAT SCAL
Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
Wagner A, 2007, BIOL PSYCHIAT, V61, P504, DOI 10.1016/j.biopsych.2007.01.001
Wood JJ, 2009, J AUTISM DEV DISORD, V39, P1608, DOI 10.1007/s10803-009-0791-7
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 30
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1773
EP 1778
DI 10.1007/s10803-013-2029-y
PG 6
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800025
PM 24379174
ER
PT J
AU Evers, K
de-Wit, L
Van der Hallen, R
Haesen, B
Steyaert, J
Noens, I
Wagemans, J
AF Evers, Kris
de-Wit, Lee
Van der Hallen, Ruth
Haesen, Birgitt
Steyaert, Jean
Noens, Ilse
Wagemans, Johan
TI Brief Report: Reduced Grouping Interference in Children with ASD:
Evidence from a Multiple Object Tracking Task
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Attention; Autism spectrum disorder (ASD); Global interference;
Grouping; Multiple object tracking; Weak central coherence
ID AUTISM SPECTRUM DISORDERS; PERCEPTUAL ORGANIZATION; VISUAL-PERCEPTION;
SPATIAL PROXIMITY; WEAK COHERENCE; MOTION; ATTENTION; INDIVIDUALS;
INTEGRATION; COLLINEARITY
AB This study was inspired by the more locally oriented processing style in autism spectrum disorders (ASD). A modified multiple object tracking (MOT) task was administered to a group of children with and without ASD. Participants not only had to distinguish moving targets from distracters, but they also had to track targets when they were visually grouped to distracters, a manipulation which has a detrimental effect on tracking performance in adults. MOT performance in the ASD group was also affected by grouping, but this effect was significantly reduced. This result highlights how the reduced bias towards more global processing in ASD could influence further stages of cognition by altering the way in which attention selects information for further processing.
C1 [Evers, Kris; de-Wit, Lee; Van der Hallen, Ruth; Haesen, Birgitt; Wagemans, Johan] Katholieke Univ Leuven, Expt Psychol Lab, B-3000 Leuven, Belgium.
[Evers, Kris; Steyaert, Jean] UPC KU Leuven, Dept Child Psychiat, Leuven, Belgium.
[Evers, Kris; Van der Hallen, Ruth; Haesen, Birgitt; Steyaert, Jean; Noens, Ilse; Wagemans, Johan] Katholieke Univ Leuven, Leuven Autism Res LAuRes, B-3000 Leuven, Belgium.
[Steyaert, Jean] Univ Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands.
[Noens, Ilse] Katholieke Univ Leuven, Parenting & Special Educ Res Unit, B-3000 Leuven, Belgium.
[Noens, Ilse] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
RP Evers, K (reprint author), Katholieke Univ Leuven, Expt Psychol Lab, Tiensestr 102,Box 3711, B-3000 Leuven, Belgium.
EM kris.evers@psy.kuleuven.be
RI Steyaert, Jean/B-5326-2015
OI Steyaert, Jean/0000-0003-2512-4694
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150
Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x
Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x
Carey S, 2001, COGNITION, V80, P179, DOI 10.1016/S0010-0277(00)00154-2
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65
Del Viva MM, 2006, VISION RES, V46, P1242, DOI 10.1016/j.visres.2005.10.018
Driver J, 2001, COGNITION, V80, P61, DOI 10.1016/S0010-0277(00)00151-7
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Falter CM, 2010, AUTISM RES, V3, P128, DOI 10.1002/aur.134
Farran EK, 2011, AUTISM RES, V4, P283, DOI 10.1002/aur.202
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Hadad B, 2010, VISION RES, V50, P772, DOI 10.1016/j.visres.2010.01.021
Hadad BS, 2006, PERCEPT PSYCHOPHYS, V68, P1264, DOI 10.3758/BF03193726
Hadad BS, 2010, J EXP CHILD PSYCHOL, V106, P163, DOI 10.1016/j.jecp.2010.02.003
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Happe FGE, 2008, Q J EXP PSYCHOL, V61, P50, DOI 10.1080/17470210701508731
Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
Hulleman J, 2005, VISION RES, V45, P2298, DOI 10.1016/j.visres.2005.02.016
Kimchi R, 2005, PSYCHOL SCI, V16, P282, DOI 10.1111/j.0956-7976.2005.01529.x
Koldewyn K, 2013, J AUTISM DEV DISORD, V43, P1394, DOI 10.1007/s10803-012-1694-6
Koldewyn K, 2013, J AUTISM DEV DISORD, V43, P2329, DOI 10.1007/s10803-013-1777-z
Kovacs I, 2000, VISION RES, V40, P1301, DOI 10.1016/S0042-6989(00)00055-9
Loth E, 2010, NEUROPSYCHOLOGIA, V48, P1227, DOI 10.1016/j.neuropsychologia.2009.12.023
Manning C, 2013, AUTISM RES, V6, P531, DOI 10.1002/aur.1309
Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018
Mitchell P, 2010, AUTISM RES, V3, P113, DOI 10.1002/aur.130
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mottron L, 2013, NEUROSCI BIOBEHAV R, V37, P209, DOI 10.1016/j.neubiorev.2012.11.016
Mottron L, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P131
O'Hearn K, 2013, J EXP PSYCHOL HUMAN, V39, P494, DOI 10.1037/a0029400
O'Hearn K, 2010, DEVELOPMENTAL SCI, V13, P430, DOI 10.1111/j.1467-7687.2009.00893.x
PALMER S, 1994, PSYCHON B REV, V1, P29, DOI 10.3758/BF03200760
Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
PYLYSHYN Z W, 1988, Spatial Vision, V3, P179, DOI 10.1163/156856888X00122
Quinn P. C., 2013, OXFORD HDB PERCEPTUA
Reed P, 2011, PERS INDIV DIFFER, V51, P732, DOI 10.1016/j.paid.2011.06.016
Roeyers H., 2012, SRS SCREENINGLIJST A
Samson F, 2012, HUM BRAIN MAPP, V33, P1553, DOI 10.1002/hbm.21307
SAS Institute, 2011, SAS SOFTW VERS 9 3 S
Sattler J. M., 2001, ASSESSMENT CHILDREN
SCAIFE M, 1975, NATURE, V253, P265, DOI 10.1038/253265a0
Scholl BJ, 2001, COGNITION, V80, P159, DOI 10.1016/S0010-0277(00)00157-8
SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031
Trick LM, 2005, COGNITIVE DEV, V20, P373, DOI 10.1016/j.cogdev.2005.05.009
Tsatsanis KD, 2011, J AUTISM DEV DISORD, V41, P135, DOI 10.1007/s10803-010-1139-z
Wechsler D., 1992, WECHSLER INTELLIGENC
White SJ, 2011, J AUTISM DEV DISORD, V41, P1565, DOI 10.1007/s10803-011-1182-4
NR 56
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1779
EP 1787
DI 10.1007/s10803-013-2031-4
PG 9
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800026
PM 24398878
ER
PT J
AU Waterhouse, L
Gillberg, C
AF Waterhouse, Lynn
Gillberg, Christopher
TI Why Autism Must be Taken Apart
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ASD; Brain dysfunction; DSM-5; Pathophysiology; RDoC
ID TUBEROUS SCLEROSIS COMPLEX; SPECTRUM DISORDERS; CLASSIFICATION;
METAANALYSIS; CEREBELLUM; HYPOPLASIA; CHILDREN; INFANTS; FUTURE; CORTEX
AB Although accumulated evidence has demonstrated that autism is found with many varied brain dysfunctions, researchers have tried to find a single brain dysfunction that would provide neurobiological validity for autism. However, unitary models of autism brain dysfunction have not adequately addressed conflicting evidence, and efforts to find a single unifying brain dysfunction have led the field away from research to explore individual variation and micro-subgroups. Autism must be taken apart in order to find neurobiological treatment targets. Three research changes are needed. The belief that there is a single defining autism spectrum disorder brain dysfunction must be relinquished. The noise caused by the thorny brain-symptom inference problem must be reduced. Researchers must explore individual variation in brain measures within autism.
C1 [Waterhouse, Lynn] Coll New Jersey, Global Grad Programs, Child Behav Study, Ewing, NJ 08628 USA.
[Gillberg, Christopher] Gothenburg Univ, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
RP Waterhouse, L (reprint author), Coll New Jersey, Global Grad Programs, Child Behav Study, Ewing, NJ 08628 USA.
EM lynwater@tcnj.edu; christopher.gillberg@pediat.gu.se
CR Allely C. S., 2013, BEHAV NEUROL, DOI [10.3233/BEN-130350, DOI 10.3233/BEN-130350]
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Aoki Y, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-25
Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
Campbell MG, 2013, BMC MED GENOMICS, V6, DOI 10.1186/1755-8794-6-34
Chaste P, 2013, BIOL PSYCHIAT, V74, P576, DOI 10.1016/j.biopsych.2013.04.018
Ciesielski KT, 1997, NEUROPSYCHOLOGIA, V35, P643, DOI 10.1016/S0028-3932(96)00119-4
CIESIELSKI KT, 1994, ACTA NEUROBIOL EXP, V54, P151
Coleman M., 2012, AUTISMS
COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
Cuthbert BN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-126
Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
Di Martino A, 2014, MOL PSYCHIATR, V19, P659, DOI 10.1038/mp.2013.78
Dove D, 2012, PEDIATRICS, V130, P717, DOI 10.1542/peds.2012-0683
Doyle Carolyn A, 2012, Dialogues Clin Neurosci, V14, P263
Fatemi SH, 2013, CEREBELLUM, V12, P778, DOI 10.1007/s12311-013-0484-9
Gillberg G., 2010, RES DEV DISABIL, V31, P1543, DOI [10.1016/j.ridd.2010.06.002, DOI 10.1016/J.RIDD.2010.06.002]
Gordon I, 2013, P NATL ACAD SCI USA, V110, P20953, DOI 10.1073/pnas.1312857110
Horder J, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.53
Insel T., 2013, TRANSFORMING DIAGNOS
Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
Kell A. J., 2013, J VISION, V13, P832, DOI [10.1167/13.9.832, DOI 10.1167/13.9.832]
Kupfer DJ, 2011, AM J PSYCHIAT, V168, P672, DOI 10.1176/appi.ajp.2011.11020219
Lai MC, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001544
Lee M, 2002, BRAIN, V125, P1483, DOI 10.1093/brain/awf160
Levitt J. G., 2013, MR SPECTROSCOPY PEDI, P213
Licinio J, 2013, MOL PSYCHIATR, V18, P846, DOI 10.1038/mp.2013.90
Marcotte L, 2012, ACTA NEUROPATHOL, V123, P685, DOI 10.1007/s00401-012-0950-3
Jonas RK, 2014, BIOL PSYCHIAT, V75, P351, DOI 10.1016/j.biopsych.2013.07.019
Moreno-De-Luca A, 2013, LANCET NEUROL, V12, P406, DOI 10.1016/S1474-4422(13)70011-5
Murdoch JD, 2013, CURR OPIN GENET DEV, V23, P310, DOI 10.1016/j.gde.2013.02.003
Peters JM, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-54
Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
Pina-Camacho L, 2012, J AUTISM DEV DISORD, V42, P1326, DOI 10.1007/s10803-011-1360-4
Raznahan A, 2013, BIOL PSYCHIAT, V74, P563, DOI 10.1016/j.biopsych.2013.03.022
Redcay E., 2013, FRONTIERS HUMAN NEUR, V7, P2013, DOI 10.3389%2Ffnhum.00573
Roullet FI, 2013, NEUROTOXICOL TERATOL, V36, P47, DOI 10.1016/j.ntt.2013.01.004
Saygin AP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013491
Schumann CM, 2011, BRAIN RES, V1380, P175, DOI 10.1016/j.brainres.2010.09.061
Shen MD, 2013, BRAIN, V136, P2825, DOI 10.1093/brain/awt166
Silver WG, 2012, PEDIATR CLIN N AM, V59, P45, DOI 10.1016/j.pcl.2011.10.010
Skudlarski P, 2013, AM J PSYCHIAT, V170, P886, DOI 10.1176/appi.ajp.2013.12111448
Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076
Tye C, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-55
Tyszka J. M., 2013, CEREB CORTEX, DOI [10.1093/cercor/bht040, DOI 10.1093/CERCOR/BHT040]
Unwin L. M., 2013, FRONTIERS HUMAN NEUR, V7, DOI 10.3389%2Ffnhum.00606
Vasa RA, 2012, J AUTISM DEV DISORD, V42, P1662, DOI 10.1007/s10803-011-1407-6
Washington SD, 2014, HUM BRAIN MAPP, V35, P1284, DOI 10.1002/hbm.22252
Waterhouse L, 2013, RETHINKING AUTISM: VARIATION AND COMPLEXITY, P1
Waterhouse L, 2008, NEUROPSYCHOL REV, V18, P273, DOI 10.1007/s11065-008-9074-x
Weisenfeld NI, 2013, PEDIATR NEUROL, V48, P105, DOI 10.1016/j.pediatrneurol.2012.10.011
Ziats MN, 2013, CEREBELLUM, V12, P776, DOI 10.1007/s12311-013-0483-x
NR 52
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUL
PY 2014
VL 44
IS 7
BP 1788
EP 1792
DI 10.1007/s10803-013-2030-5
PG 5
WC Psychology, Developmental
SC Psychology
GA AJ5TY
UT WOS:000337752800027
PM 24390538
ER
PT J
AU O'Nions, E
Christie, P
Gould, J
Viding, E
Happe, F
AF O'Nions, Elizabeth
Christie, Phil
Gould, Judith
Viding, Essi
Happe, Francesca
TI Development of the "Extreme Demand Avoidance Questionnaire' (EDA-Q):
preliminary observations on a trait measure for Pathological Demand
Avoidance
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; ASD; pathological demand avoidance; PDA;
pervasive developmental disorder; conduct problems; oppositional defiant
disorder; ODD; disruptive behaviour
ID DIFFICULTIES QUESTIONNAIRE; DISORDERS; STRENGTHS
AB Background Pathological Demand Avoidance (PDA) is a term increasingly used in the United Kingdom to describe children who obsessively resist everyday demands, going to extreme lengths to avoid these. There is debate about its relationship with both autism spectrum disorder (ASD) and oppositional defiant disorder (ODD). Unlike ASD, children with PDA are said to use socially manipulative avoidance strategies; and unlike ODD, they resort to extreme, embarrassing or age-inappropriate behaviour. To date, there has been little research into PDA, and it remains contentious. Currently, there are no questionnaire instruments available to aid consistency in description. This study reports the development and preliminary validation of the Extreme Demand Avoidance Questionnaire' (EDA-Q), designed to quantify PDA traits based on parent-reported information. Methods The validation study involved data from 326 parents of children aged 5-17 allocated to six groups based on information reported by parents about received diagnoses and behavioural difficulties: (a) typically developing children (N=102), (b) children with ASD without disruptive behaviour (N=36), (c) children with ASD with disruptive behaviour (N=48), (d) children for whom PDA was suspected by parents (irrespective of other diagnoses) (N=67), (e) children who had, according to parents, been identified as having PDA by a health professional, irrespective of other diagnoses (N=50), and (6) disruptive behaviour or behavioural problems without suspected/identified ASD or PDA (N=23). Results Although the Strengths and Difficulties Questionnaire (SDQ) did not differentiate PDA from those with ASD plus disruptive behaviour; score on the EDA-Q was significantly higher in PDA than all comparison groups. ROC analysis indicated good sensitivity (.80) and specificity (.85). Across all case groups, females scored higher than males on the EDA-Q. Separate cut-off scores were identified for older and younger age-groups. Conclusions Our findings highlight the potential utility of the EDA-Q to assist the identification of this unusual profile for future research.
C1 [O'Nions, Elizabeth; Happe, Francesca] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
[Christie, Phil] Sutherland House Childrens Serv NORSACA, Elizabeth Newson Ctr, Southwold, Notts, England.
[Gould, Judith] NAS Lorna Wing Ctr Autism, Bromley, Kent, England.
[Viding, Essi] UCL, Dev Risk & Resilience Unit, Div Psychol & Language Sci, Clin Educ & Hlth Psychol Res Dept, London, England.
RP O'Nions, E (reprint author), Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat, Denmark Hill, London SE5 8AF, England.
EM elizabeth.onions@kcl.ac.uk
FU ESRC
FX E. O'N is supported by an ESRC PhD studentship. P. C. receives payment
for consultancy and training from voluntary and statutory bodies. The
authors have declared that they have no competing or potential conflicts
of interest. The authors are very grateful to the clinicians who
assisted in developing the measure. They are also very grateful to the
parents who took part in this study; and to the schools, parent groups
and web groups who assisted with recruitment and supported this
research.
CR Christie P., 2007, GOOD AUTISM PRACTICE, V8, P3
Frick P J, 1999, Clin Child Fam Psychol Rev, V2, P149, DOI 10.1023/A:1021803005547
Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Gould J., 2011, GOOD AUTISM PRACTICE, V12, P34
Kopp S, 2011, RES DEV DISABIL, V32, P2875, DOI 10.1016/j.ridd.2011.05.017
Newson E, 2003, ARCH DIS CHILD, V88, P595, DOI 10.1136/adc.88.7.595
O'Nions E., AUTISM INT IN PRESS
Viding E, 2012, J ROY SOC MED, V105, P195, DOI 10.1258/jrsm.2011.110223
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
NR 10
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUL
PY 2014
VL 55
IS 7
BP 758
EP 768
DI 10.1111/jcpp.12149
PG 11
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AJ9DW
UT WOS:000338008300003
PM 24117718
ER
PT J
AU Musser, ED
Hawkey, E
Kachan-Liu, SS
Lees, P
Roullet, JB
Goddard, K
Steiner, RD
Nigg, JT
AF Musser, Erica D.
Hawkey, Elizabeth
Kachan-Liu, Svetlana S.
Lees, Paul
Roullet, Jean-Baptiste
Goddard, Katrina
Steiner, Robert D.
Nigg, Joel T.
TI Shared familial transmission of autism spectrum and
attention-deficit/hyperactivity disorders
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Attention-deficit; hyperactivity disorder; autism spectrum disorder;
shared familial transmission
ID DEFICIT-HYPERACTIVITY DISORDER; PSYCHIATRIC-DISORDERS; GENETIC
INFLUENCES; TWIN SAMPLE; CHILDREN; SYMPTOMS; ADHD; ADOLESCENTS;
PREVALENCE; PSYCHOPATHOLOGY
AB Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n=35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6-12years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR=5.02, p<.0001) and at 2.5-fold risk of ASD alone (OR=2.52, p<.01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis.
C1 [Musser, Erica D.; Hawkey, Elizabeth; Roullet, Jean-Baptiste; Nigg, Joel T.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Musser, Erica D.] Univ Oregon, Eugene, OR 97403 USA.
[Kachan-Liu, Svetlana S.] Johns Hopkins Sch Med, Baltimore, MD USA.
[Lees, Paul; Goddard, Katrina] Kaiser Permanente Northwest, Portland, OR USA.
[Steiner, Robert D.] Univ Wisconsin, Marshfield Clin Res Fdn, Marshfield, WI USA.
RP Musser, ED (reprint author), Coll Arts & Sci, Dept Psychol, 11200 SW 8th St,AHC4-455, Miami, FL 33199 USA.
EM mussere@ohsu.edu
FU NIMH [R01-MH59105]
FX This research was supported in part by NIMH R01-MH59105, awarded to
J.T.N. E.D.M co-conceptualized the study, carried out the analyses,
drafted the initial manuscript; E. H assisted with data assembly and
data set preparation; S. S. K assisted in analysis, reviewed the
manuscript; P. L assisted with the retrieval and organization of the
data; J-B.R assisted in conceptualization of the study; K. G assisted
with the retrieval and organization of the data; R. D. S assisted in
conceptualization of the study, helped obtain the data; J.T.N
co-conceptualized the study, oversaw the analyses, critically reviewed
and helped draft the manuscript. The authors thank Jennifer Stubbs and
Oregon Clinical & Translational Research for regulatory assistance, as
well as Kaiser Permanente Northwest for their support and access to the
data. All the authors critically reviewed and approved the final
manuscript. All authors declare that they have no potential or competing
conflicts of interest.
CR Akinbami L. J., 2011, CTR DIS CONTROL, V70, P1
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bakker SC, 2003, AM J HUM GENET, V72, P1251, DOI 10.1086/375143
Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x
CANTWELL DP, 1988, J AM ACAD CHILD PSY, V27, P521, DOI 10.1097/00004583-198809000-00001
Centers for Disease Control, 2013, STAT BAS PREV DAT PA
Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50
Erskine HE, 2013, J CHILD PSYCHOL PSYC, V54, P1263, DOI 10.1111/jcpp.12144
Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69
Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x
Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
Gaub M, 1997, J AM ACAD CHILD PSY, V36, P1036, DOI 10.1097/00004583-199708000-00011
Gershon J, 2002, J Atten Disord, V5, P143, DOI 10.1177/108705470200500302
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Mulligan A, 2009, J AUTISM DEV DISORD, V39, P197, DOI 10.1007/s10803-008-0621-3
Muthen & Muthen, 2012, M PLUS VERS 6 11
Nijmeijer JS, 2009, J ABNORM CHILD PSYCH, V37, P443, DOI 10.1007/s10802-008-9282-0
Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
Pamplona FA, 2009, PROG NEURO-PSYCHOPH, V33, P1153, DOI 10.1016/j.pnpbp.2009.06.012
Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Reiersen AM, 2008, J AM ACAD CHILD PSY, V47, P662, DOI 10.1097/CHI.0b013e31816bff88
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Rowlandson PH, 2009, CHILD CARE HLTH DEV, V35, P681, DOI 10.1111/j.1365-2214.2009.00956.x
Sandin S, 2012, J AM ACAD CHILD PSY, V51, P477, DOI 10.1016/j.jaac.2012.02.018
Santosh PJ, 2004, EUR CHILD ADOLES PSY, V13, P141, DOI 10.1007/s00787-004-0372-4
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
Smalley SL, 1997, AM J HUM GENET, V60, P1276, DOI 10.1086/515485
Stone JL, 2004, AM J HUM GENET, V75, P1117, DOI 10.1086/426034
van Steijn DJ, 2012, J CHILD PSYCHOL PSYC, V53, P954, DOI 10.1111/j.1469-7610.2012.02556.x
Weiss LA, 2009, EXPERT REV MOL DIAGN, V9, P795, DOI [10.1586/erm.09.59, 10.1586/ERM.09.59]
NR 40
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUL
PY 2014
VL 55
IS 7
BP 819
EP 827
DI 10.1111/jcpp.12201
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AJ9DW
UT WOS:000338008300011
PM 24444366
ER
PT J
AU Belling, R
McLaren, S
Paul, M
Ford, T
Kramer, T
Weaver, T
Hovish, K
Islam, Z
White, S
Singh, SP
AF Belling, Ruth
McLaren, Susan
Paul, Moli
Ford, Tamsin
Kramer, Tami
Weaver, Tim
Hovish, Kimberly
Islam, Zoebia
White, Sarah
Singh, Swaran P.
TI The effect of organisational resources and eligibility issues on
transition from child and adolescent to adult mental health services
SO JOURNAL OF HEALTH SERVICES RESEARCH & POLICY
LA English
DT Article
DE resources; transition from child/adolescent to adult mental health
services
ID CARE
AB Objectives: To investigate the organisational factors that impede or facilitate transition of young people from child and adolescent (CAMHS) to adult mental health services (AMHS).
Methods: Thirty-four semi-structured interviews were conducted with health and social care professionals working in child and adult services in four English NHS Mental Health Trusts and voluntary organisations. Data were analysed thematically using a structured framework.
Results: Findings revealed a lack of clarity on service availability and the operation of different eligibility criteria between child and adult mental health services, with variable service provision for young people with attention deficit hyperactivity disorder, autism spectrum disorders and learning disabilities. High workloads and staff shortages were perceived to influence service thresholds and eligibility criteria.
Conclusions: A mutual lack of understanding of services and structures together with restrictive eligibility criteria exacerbated by perceived lack of resources can impact negatively on the transition between CAMHS and AMHS, disrupting continuity of care for young people.
C1 [Belling, Ruth] Evaluat Works, Bedford, England.
[McLaren, Susan] London S Bank Univ, Fac Hlth & Social Care, London SE1 0AA, England.
[Paul, Moli; Singh, Swaran P.] Univ Warwick, Warwick Med Sch, Div Mental Hlth & Well Being, Coventry CV4 7AL, W Midlands, England.
[Ford, Tamsin] Univ Exeter, Sch Med, Exeter EX4 4QJ, Devon, England.
[Kramer, Tami; Weaver, Tim] Imperial Coll London, Fac Med, London, England.
[Hovish, Kimberly] Univ London, Inst Educ, Dept Childhood Families & Hlth, London WC1E 7HU, England.
[Islam, Zoebia] Leicestershire & Rutland & Birmingham & Solihull, LOROS Hosp Care Leicester, Birmingham, W Midlands, England.
[White, Sarah] Univ London, Sect Mental Hlth, Div Populat Hlth Sci & Educ, London WC1E 7HU, England.
RP McLaren, S (reprint author), London S Bank Univ, Fac Hlth & Social Care, London SE1 0AA, England.
EM mclaresm@lsbu.ac.uk
CR American Academy of Pediatrics American Academy of Family Physicians & American College of Physicians-American Society of Internal Medicine., 2002, PEDIATRICS, V110, P1304
Audit Commission, 1999, CHILDR MIND
Burns T., 2007, EXPERIENCES CONTINUI
Crawley R, 2011, ARCH DIS CHILD, V96, P548
Davis M, 2006, PSYCHIAT SERV, V57, P1594, DOI 10.1176/appi.ps.57.11.1594
Davis M, 2009, TRANSITION YOUTH YOU
Department of Health, 2004, NAT SERV FRAM CHILDR
Department of Health, 2010, MOD MULT SERV TRANS
Department of Health Partnerships for Children Families and Maternity/CNO Directorate, 2008, TRANS MOV WELL GOOD
Freeman G, 2002, PROMOTING CONTINUITY
Harpaz Rotem I, 2004, PSYCHIAT SERV, V55, P1022
Hovish K, 2012, PSYCHIATR REHABIL J, V35, P251, DOI 10.2975/35.3.2012.251.257
Joint Commissioning Panel for Mental Health, 2012, GUID COMM MENT HLTH
McGorry PD, 2007, MED J AUSTRALIA, V187, pS53
McLaren S, 2013, BMC HEALTH SERV RES, V13, DOI 10.1186/1472-6963-13-254
National CAMHS Review, 2008, CHILDR YOUNG PEOPL M
Nutt DJ, 2007, J PSYCHOPHARMACOL, V21, P10, DOI 10.1177/0269881106073219
Paul M, 2013, BR J PSYCHIAT S54, V202, ps36, DOI DOI 10.1192/BJP.BP.112.119198
Ritchie J, 1994, ANAL QUALITATIVE DAT
Singh SP, 2008, BMC HEALTH SERV RES, V8, DOI 10.1186/1472-6963-8-135
Singh SP, 2005, PSYCHIAT B, V29, P292, DOI 10.1192/pb.29.8.292
Singh SP, 2009, 081613117 NETSCC SDO
Singh SP, 2010, BRIT J PSYCHIAT, V197, P305, DOI 10.1192/bjp.bp.109.075135
Singh SP, 2009, CURR OPIN PSYCHIATR, V22, P386, DOI 10.1097/YCO.0b013e32832c9221
Social Exclusion Unit, 2005, TRANS YOUNG AD COMPL
Treasure J, 2005, BRIT J PSYCHIAT, V187, P398, DOI 10.1192/bjp.187.5.398
Vloet Melissa A, 2011, Healthc Q, V14 Spec No, P32
NR 27
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1355-8196
EI 1758-1060
J9 J HEALTH SERV RES PO
JI J. Health Serv. Res. Policy
PD JUL
PY 2014
VL 19
IS 3
BP 169
EP 176
DI 10.1177/1355819614527439
PG 8
WC Health Policy & Services
SC Health Care Sciences & Services
GA AJ8MK
UT WOS:000337958800007
ER
PT J
AU Casanova, MF
AF Casanova, Manuel F.
TI Autism as a sequence: From heterochronic germinal cell divisions to
abnormalities of cell migration and cortical dysplasias
SO MEDICAL HYPOTHESES
LA English
DT Article
ID LEMLI-OPITZ-SYNDROME; PERIVENTRICULAR NODULAR HETEROTOPIA; TUBEROUS
SCLEROSIS COMPLEX; PRENATAL COCAINE EXPOSURE; EHLERS-DANLOS-SYNDROME;
FINAL COMMON PATHWAY; SPECTRUM DISORDERS; NEURONAL MIGRATION; PREFRONTAL
CORTEX; BRAIN
AB The considerable heterogeneity in the number and severity of symptoms observed in autism spectrum disorders (ASD) has been regarded as an obstacle to any future research. Some authors believe that clinical heterogeneity results from the complex interplay of the many genetic and environmental factors that themselves define a condition as multifactorial. However, it is important to note that neuropathological findings in both idiopathic and syndromic autism suggests a single pathophysiological mechanism acting during brain development: the heterochronic division of germinal cells and subsequent migrational abnormalities of daughter cells to their target fields. Multiple exogenous (e.g., viruses, drugs) and endogenous (e.g., genetic mutations) factors are known to disrupt the division of germinal cells and provide for an autism phenotype. The variety of endogenous and exogenous factors, their timing of action during brain development, and the genetic susceptibility of affected individuals (a Triple Hit hypothesis) may all account for the clinical heterogeneity of ASD. Published by Elsevier Ltd.
C1 Univ Louisville, Dept Psychiat, Louisville, KY 40202 USA.
RP Casanova, MF (reprint author), Univ Louisville, Dept Psychiat, 500 South Preston St,Bldg A,Room 217, Louisville, KY 40202 USA.
EM m0casa02@louisville.edu
FU National Institutes of Health [R01 MH-86784]
FX The author received funding from National Institutes of Health grant R01
MH-86784 "Building a selective inhibitory control tone in autism: an
rTMS study".
CR AIELLO LC, 1995, CURR ANTHROPOL, V36, P199, DOI 10.1086/204350
American Psychiatric Association, 2013, DIAGN STA MAN MENT D
Ang ESBC, 2006, P NATL ACAD SCI USA, V103, P12903, DOI 10.1073/pnas.0605294103
Avino TA, 2010, BRAIN RES, V1360, P138, DOI 10.1016/j.brainres.2010.08.091
Bae MH, 2010, EXP NEUROL, V221, P129, DOI 10.1016/j.expneurol.2009.10.011
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
BALL MJ, 1985, LANCET, V1, P14
Ball MJ, 2006, ALZHEIMER'S DISEASE: A CENTURY OF SCIENTIFIC AND CLINICAL RESEARCH, P29
Ballabh P, 2010, PEDIATR RES, V67, P1, DOI 10.1203/PDR.0b013e3181c1b176
Bandim JM, 2003, ARQ NEURO-PSIQUIAT, V61, P181, DOI 10.1590/S0004-282X2003000200004
Bauman ML, 1994, NEUROBIOLOGY AUTISM, P119
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P187
Bellak L, 1958, SCHIZOPHRENIA REV SY
Berger NE, 2011, BMC PUBLIC HEALTH, V11, P340
Bissonette GB, 2014, BEHAV BRAIN RES, V259, P143, DOI 10.1016/j.bbr.2013.10.051
Bolton PF, 2002, BRAIN, V125, P1247, DOI 10.1093/brain/awf124
Boucher J., 2011, NEUROPSYCHOLOGY AUTI, P469
Casanova MF, 2012, NEUROSCIENCE AUTISM, P327
Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x
Casanova MF, 2002, NEUROLOGY, V58, P428
Casanova Manuel F, 2013, Acta Neuropathol Commun, V1, P67, DOI 10.1186/2051-5960-1-67
Casanova MF, 2010, BRAIN PATHOL, V20, P451, DOI 10.1111/j.1750-3639.2009.00319.x
Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
Casanova MF, 2008, NEUROSCIENTIST, V14, P101, DOI 10.1177/1073858407309091
Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
Chang BS, 2005, NEUROLOGY, V64, P799
CHERSTVOY ED, 1984, VIRCHOWS ARCH A, V404, P413, DOI 10.1007/BF00695225
CHERSTVOY ED, 1975, CLIN GENET, V7, P382
Coleman M., 2011, AUTISMS
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
Cunha Carla, 2010, Front Mol Neurosci, V3, P1, DOI 10.3389/neuro.02.001.2010
CUPO LN, 1981, AM J MED, V71, P1051, DOI 10.1016/0002-9343(81)90341-7
DARBY JK, 1992, AM J PSYCHIAT, V149, P146
DARBY JK, 1976, J AUTISM CHILD SCHIZ, V6, P339, DOI 10.1007/BF01537911
Fatemi SH, 2001, NEUROREPORT, V12, P3209, DOI 10.1097/00001756-200110290-00014
Fatemi SH, 2001, J AUTISM DEV DISORD, V31, P529, DOI 10.1023/A:1013234708757
Feinstein Adam, 2010, HIST AUTISM CONVERSA
Fry AE, 2013, J NEUROPSYCH CLIN N, V25, P26, DOI 10.1176/appi.neuropsych.11110336
George Mark S., 2007, TRANSCRANIAL MAGNETI
Gomez-Garre P, 2006, J MED GENET, V43, P232, DOI 10.1136/jmg.2004.029173
Griffiths PD, 1998, ACTA RADIOL, V39, P482
Holt R, 2011, EMBO MOL MED, V3, P438, DOI 10.1002/emmm.201100157
Howes OD, 2009, SCHIZOPHRENIA BULL, V35, P549, DOI 10.1093/schbul/sbp006
Hutsler JJ, 2007, BIOL PSYCHIAT, V61, P449, DOI 10.1016/j.biopsych.2006.01.015
Jacot-Descombes S, 2012, ACTA NEUROPATHOL, V124, P67, DOI 10.1007/s00401-012-0976-6
KANKIRAWATANA P, 1993, PEDIATR NEUROL, V9, P71, DOI 10.1016/0887-8994(93)90016-6
Kanner L, 1943, NERV CHILD, V2, P217
Kennedy H, 2012, PROG BRAIN RES, V195, P341, DOI 10.1016/B978-0-444-53860-4.00016-7
Limperopoulos C, 2009, CLIN PERINATOL, V36, P791, DOI 10.1016/j.clp.2009.07.010
Lyall K, 2013, INT J ENV RES PUB HE, V10, P3715, DOI 10.3390/ijerph10083715
Mattson MP, 2006, NAT REV NEUROSCI, V7, P278, DOI 10.1038/nrn1886
McClintic AM, 2014, AUTISM RES, V7, P295, DOI 10.1002/aur.1349
Monuki ES, 2004, DEV NEUROPATHOLOGY, P52
Movsas TZ, 2013, J PEDIATR-US, V163, P73, DOI 10.1016/j.jpeds.2012.12.084
Mukaetova-Ladinska EB, 2004, NEUROPATH APPL NEURO, V30, P615, DOI 10.1111/j.1365-2990.2004.00574.x
Noorbakhsh S., 2010, Iranian Journal of Clinical Infectious Diseases, V5, P9
NOWELL MA, 1990, MAGN RESON IMAGING, V8, P811, DOI 10.1016/0730-725X(90)90018-W
Patel DA, 2012, INT J DEV NEUROSCI, V30, P1, DOI 10.1016/j.ijdevneu.2011.11.001
Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
Peters A, 2004, NEUROSCI BIOBEHAV R, V28, P143, DOI 10.1016/j.neubiorev.2004.03.002
Ren JQ, 2004, INT J DEV NEUROSCI, V22, P309, DOI 10.1016/j.ijdevneu.2004.05.003
Ringstedt T, 1998, NEURON, V21, P305, DOI 10.1016/S0896-6273(00)80540-1
Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
Schmitz C, 2008, NEUROPATH APPL NEURO, V34, P4, DOI 10.1111/j.1365-2990.2007.00872.x
Scott R., 2013, AUTISMS SNOWFLAKE DO
SHACKELFORD GD, 1983, RADIOLOGY, V149, P117
Sheen Volney L, 2005, Clin Med Res, V3, P229
Sikora DM, 2006, AM J MED GENET A, V140A, P1511, DOI 10.1002/ajmg.a.31294
Simms ML, 2009, ACTA NEUROPATHOL, V118, P673, DOI 10.1007/s00401-009-0568-2
Smalley SL, 1998, J AUTISM DEV DISORD, V28, P407, DOI 10.1023/A:1026052421693
Stanton MT, 2001, LIFE SCI, V68, P1471, DOI 10.1016/S0024-3205(01)00940-7
Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773
STUBBS EG, 1978, J AUTISM CHILD SCHIZ, V8, P37, DOI 10.1007/BF01550276
Volpe JJ, 1997, CLIN PERINATOL, V24, P567
Waterhouse L, 2013, RETHINKING AUTISM: VARIATION AND COMPLEXITY, P1
Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
Williams EL, 2010, MED HYPOTHESES, V75, P53, DOI 10.1016/j.mehy.2010.01.027
Williams EL, 2011, TRANSL NEUROSCI, V2, P106, DOI 10.2478/s13380-011-0016-3
Williams EL, 2010, MED HYPOTHESES, V74, P59, DOI 10.1016/j.mehy.2009.08.003
Yamshita Y, 2003, J AUTISM DEV DISORD, V33, P455
Zhang Y, 2012, J CHILD NEUROL, V27, P975, DOI 10.1177/0883073811430163
Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 82
TC 1
Z9 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2014
VL 83
IS 1
BP 32
EP 38
DI 10.1016/j.mehy.2014.04.014
PG 7
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AJ7NW
UT WOS:000337884400007
PM 24780284
ER
PT J
AU Uddin, M
Tammimies, K
Pellecchia, G
Alipanahi, B
Hui, PZ
Wang, ZZ
Pinto, D
Lau, L
Nalpathamkalam, T
Marshall, CR
Blencowe, BJ
Frey, BJ
Merico, D
Yuen, RKC
Scherer, SW
AF Uddin, Mohammed
Tammimies, Kristiina
Pellecchia, Giovanna
Alipanahi, Babak
Hui, Pingzhao
Wang, Zhuozhi
Pinto, Dalila
Lau, Lynette
Nalpathamkalam, Thomas
Marshall, Christian R.
Blencowe, Benjamin J.
Frey, Brendan J.
Merico, Daniele
Yuen, Ryan K. C.
Scherer, Stephen W.
TI Brain-expressed exons under purifying selection are enriched for de novo
mutations in autism spectrum disorder
SO NATURE GENETICS
LA English
DT Article
ID COPY-NUMBER VARIATION; INTELLECTUAL DISABILITY; FUNCTIONAL IMPACT;
VARIANTS; EXOMES; SCHIZOPHRENIA; EVOLUTION; DELETIONS; PATHWAYS;
PARADIGM
AB A universal challenge in genetic studies of autism spectrum disorders (ASDs) is determining whether a given DNA sequence alteration will manifest as disease. Among different population controls, we observed, for specific exons, an inverse correlation between exon expression level in brain and burden of rare missense mutations. For genes that harbor de novo mutations predicted to be deleterious, we found that specific critical exons were significantly enriched in individuals with ASD relative to their siblings without ASD (P < 1.13 x 10(-38); odds ratio (OR) = 2.40). Furthermore, our analysis of genes with high exonic expression in brain and low burden of rare mutations demonstrated enrichment for known ASD-associated genes (P < 3.40 x 10(-11); OR = 6.08) and ASD-relevant fragile-X protein targets (P < 2.91 x 10(-157); OR = 9.52). Our results suggest that brain-expressed exons under purifying selection should be prioritized in genotype-phenotype studies for ASD and related neurodevelopmental conditions.
C1 [Uddin, Mohammed; Tammimies, Kristiina; Pellecchia, Giovanna; Hui, Pingzhao; Wang, Zhuozhi; Lau, Lynette; Nalpathamkalam, Thomas; Marshall, Christian R.; Merico, Daniele; Yuen, Ryan K. C.; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada.
[Tammimies, Kristiina] Karolinska Inst, Dept Womens & Childrens Hlth, Neuropsychiat Unit, Ctr Neurodev Disorders KIND, Stockholm, Sweden.
[Alipanahi, Babak; Frey, Brendan J.] Univ Toronto, Dept Elect & Comp Engn, Toronto, ON, Canada.
[Pinto, Dalila] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[Pinto, Dalila] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
[Pinto, Dalila] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
[Marshall, Christian R.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON, Canada.
[Blencowe, Benjamin J.; Frey, Brendan J.] Univ Toronto, Donnelly Ctr, Toronto, ON, Canada.
[Blencowe, Benjamin J.; Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
RP Scherer, SW (reprint author), Hosp Sick Children, Ctr Appl Genom, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM stephen.scherer@sickkids.ca
RI Scherer, Stephen /B-3785-2013; Yuen, Ryan/J-4876-2012
OI Scherer, Stephen /0000-0002-8326-1999;
FU University of Toronto McLaughlin Centre, NeuroDevNet, Genome Canada;
Ontario Genomics Institute [4445]; Canadian Institutes for Health
Research (CIHR) [FEN 74527, FRNXGG818]; Canadian Institute for Advanced
Research; Canada Foundation for Innovation; government of Ontario
[GL2-01-013]; Ontario Brain Institute; Autism Speaks Meixner; Swedish
Research Council
FX We thank the Centre for Applied Genomics for informatics support, the
Allen Institute of Brain Science, the National Heart, Lung, and Blood
Institute (NHLBI) and the Autism Genome Project for sharing data. We
thank J. Buchanan for critical review and editing of the manuscript.
This work was supported by grants from the University of Toronto
McLaughlin Centre, NeuroDevNet, Genome Canada and the Ontario Genomics
Institute (project 4445), the Canadian Institutes for Health Research
(CIHR) (FEN 74527 and FRNXGG818), the Canadian Institute for Advanced
Research, the Canada Foundation for Innovation, the government of
Ontario (GL2-01-013), the Ontario Brain Institute and Autism Speaks.
R.K.C.Y. holds an Autism Speaks Meixner Fellowship in Translational
Research. K.T. holds a fellowship from the Swedish Research Council.
S.W.S. holds the GlaxoSmithKline-CIHR Chair in Genome Sciences at the
University of Toronto and the Hospital for Sick Children.
CR Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
Barash Y, 2010, NATURE, V465, P53, DOI 10.1038/nature09000
Bayes A, 2011, NAT NEUROSCI, V14, P19, DOI 10.1038/nn.2719
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Beunders G, 2013, AM J HUM GENET, V92, P210, DOI 10.1016/j.ajhg.2012.12.011
Crepel A, 2011, AM J MED GENET B, V156B, P243, DOI 10.1002/ajmg.b.31163
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Fu WQ, 2013, NATURE, V493, P216, DOI 10.1038/nature11690
Gratten J, 2013, NAT GENET, V45, P234, DOI 10.1038/ng.2555
Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Khurana E, 2013, SCIENCE, V342, P84, DOI 10.1126/science.1235587
Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
Lionel AC, 2014, HUM MOL GENET, V23, P2752, DOI 10.1093/hmg/ddt669
lossifov I., 2012, NEURON, V74, P285
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
Petrovski S, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003709
Pinto D, 2014, AM J HUM GENET, V94, P677, DOI 10.1016/j.ajhg.2014.03.018
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Tennessen JA, 2012, SCIENCE, V337, P64, DOI 10.1126/science.1219240
Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
NR 35
TC 17
Z9 18
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
EI 1546-1718
J9 NAT GENET
JI Nature Genet.
PD JUL
PY 2014
VL 46
IS 7
BP 742
EP 747
DI 10.1038/ng.2980
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AK0HP
UT WOS:000338093800017
PM 24859339
ER
PT J
AU Ezegwui, IR
Lawrence, L
Aghaji, AE
Okoye, OI
Okoye, O
Onwasigwe, EN
Ebigbo, PO
AF Ezegwui, I. R.
Lawrence, L.
Aghaji, A. E.
Okoye, O. I.
Okoye, O.
Onwasigwe, E. N.
Ebigbo, P. O.
TI Refractive errors in children with autism in a developing country
SO NIGERIAN JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE Autism; developing country; refractive error
ID DISORDERS; NEEDS
AB Background: In a resource-limited country visual problems of mentally challenged individuals are often neglected. Aim: The present study aims to study refractive errors in children diagnosed with autism in a developing country.
Materials and Methods: Ophthalmic examination was carried out on children diagnosed with autism attending a school for the mentally challenged in Enugu, Nigeria between December 2009 and May 2010. Visual acuity was assessed using Lea symbols. Anterior and posterior segments were examined. Cycloplegic refraction was performed. Data was entered on the protocol prepared for the study and analyzed using Statistical Package for the Social Sciences version 17 (Chicago IL, USA).
Results: A total of 21 children with autism were enrolled in the school; 18 of whom were examined giving coverage of 85.7%. The age range was 5-15 years, with a mean of 10.28 years (standard deviation +/- 3.20). There were 13 boys and 5 girls. One child had bilateral temporal pallor of the disc and one had bilateral maculopathy with diffuse chorioretinal atrophy. Refraction revealed 4 children (22.2%) had astigmatism and 2 children (11.1%) had hypermetropia.
Conclusion: Significant refractive error mainly astigmatism was noted in the children with autism. Identifying refractive errors in these children early and providing appropriate corrective lenses may help optimize their visual functioning and impact their activities of daily life in a positive way.
C1 [Ezegwui, I. R.; Aghaji, A. E.; Okoye, O. I.; Okoye, O.; Onwasigwe, E. N.] Univ Nigeria, Teaching Hosp, Dept Ophthalmol, Enugu, Nigeria.
[Ebigbo, P. O.] Univ Nigeria, Teaching Hosp, Dept Psychol Med, Enugu, Nigeria.
RP Ezegwui, IR (reprint author), Univ Nigeria, Teaching Hosp, Dept Ophthalmol, Enugu, Nigeria.
EM ifeoma.ezegwui@unn.edu.ng
CR Aghaji AE, 2013, EUR J OPHTHALMOL, V23, P394, DOI 10.5301/ejo.5000222
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
[Anonymous], 2011, P WORKSH US DAT EV C
Autism Speaks, WHAT IS AUT
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Denis D, 1997, J FR OPHTALMOL, V20, P103
Eze BI, 2009, HUM RESOUR HEALTH, V7, DOI 10.1186/1478-4491-7-38
Ezegwui IR, 2011, INT J OPHTHALMOL-CHI, V4, P66, DOI 10.3980/j.issn.2222-3959.2011.01.15
Gogate P, 2011, INDIAN J OPHTHALMOL, V59, P223, DOI 10.4103/0301-4738.81036
Ikeda J, 2013, J AUTISM DEV DISORD, V43, P1447, DOI 10.1007/s10803-012-1475-2
Kemner C, 1998, J AUTISM DEV DISORD, V28, P61, DOI 10.1023/A:1026015120128
Miller Marilyn T, 2004, Trans Am Ophthalmol Soc, V102, P107
Miller M T, 1998, Trans Am Ophthalmol Soc, V96, P369
Nowinski CV, 2005, PSYCHIAT RES, V137, P11, DOI 10.1016/j.psychres.2005.07.005
Odusote K A, 1998, West Afr J Med, V17, P1
Omoti A E, 2007, Niger Postgrad Med J, V14, P310
Pensiero S, 2009, FUNCT NEUROL, V24, P153
SCHARRE JE, 1992, OPTOMETRY VISION SCI, V69, P433, DOI 10.1097/00006324-199206000-00004
Stanley-Cary C, 2011, CEREBELLUM, V10, P70, DOI 10.1007/s12311-010-0229-y
Trachtman Joseph N, 2008, Optometry, V79, P391, DOI 10.1016/j.optm.2007.10.015
NR 20
TC 0
Z9 0
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
INDIA
SN 1119-3077
J9 NIGER J CLIN PRACT
JI Niger. J. Clin. Pract.
PD JUL-AUG
PY 2014
VL 17
IS 4
BP 467
EP 470
DI 10.4103/1119-3077.134042
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA AJ7YW
UT WOS:000337919200013
PM 24909471
ER
PT J
AU Elmose, M
Trillingsgaard, A
Jorgensen, M
Nielsen, A
Bruhn, SS
Sorensen, EU
AF Elmose, Mette
Trillingsgaard, Anegen
Jorgensen, Meta
Nielsen, Asta
Bruhn, Susanne S.
Sorensen, Ester U.
TI Follow-up at mid-school age (9-13 years) of children assessed for autism
spectrum disorder before the age of four
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; Diagnostic stability; Follow-up; Outcome;
Prediction
ID DIAGNOSTIC-OBSERVATION-SCHEDULE; PERVASIVE DEVELOPMENTAL DISORDERS;
BEHAVIORAL INTERVENTION; REVISED ALGORITHMS; YOUNG-CHILDREN; PRESCHOOL;
PREDICTORS; STABILITY; VALIDITY; TIME
AB Background : Studies of diagnosis and outcome in mid-school age children (9-13 years) referred early in life for a suspected autism spectrum disorder (ASD) are scarce.
Aims : This study aimed to describe outcome, developmental change and the stability of the early diagnosis in mid-school age.
Methods : Children consecutively referred to a specialized autism unit at a regional psychiatric diagnostic centre in Denmark before the age of 4 were contacted in mid-school age (9-13 years). 14 children with ASD and 9 children diagnosed outside the spectrum were included. Current clinical diagnosis, autism characteristics, intellectual abilities and adaptive functioning were assessed at follow-up, and investigated in relation to early measures of intellectual abilities and difficulties in social and communicative situations.
Results : The stability of an early ASD diagnosis was confirmed. However, a high degree of change into the autism spectrum was found for children who were initially diagnosed with another developmental disorder. A positive change with regard to IQ level was evident at the individual level. At group level, there was a tendency for lower functioning in the children diagnosed early with ASD. Early measures of intellectual abilities, and of social and communicative difficulties, predicted between 16% and 50% of the variance in intellectual abilities and adaptive functioning.
Conclusions: The findings are in line with follow-up studies in preschool and early school age but highlight the need to monitor early diagnostic decisions, and the need for more nuanced baseline and outcome measures that may help increase our prognostic understanding.
C1 [Elmose, Mette] Univ Southern Denmark, Dept Psychol, DK-5230 Odense M, Denmark.
[Elmose, Mette; Trillingsgaard, Anegen] Univ Aarhus, Dept Psychol, Aarhus C, Denmark.
[Trillingsgaard, Anegen; Jorgensen, Meta; Nielsen, Asta; Bruhn, Susanne S.; Sorensen, Ester U.] Aarhus Univ Hosp, Reg Ctr Child & Adolescent Psychiat, Risskov, Denmark.
RP Elmose, M (reprint author), Univ Southern Denmark, Dept Psychol, Campusvej 55, DK-5230 Odense M, Denmark.
EM melandersen@health.sdu.dk
CR Baghdadli A, 2007, ACTA PSYCHIAT SCAND, V115, P403, DOI 10.1111/j.1600-0447.2006.00898.x
Ben-Itzchak E, 2007, RES DEV DISABIL, V28, P287, DOI 10.1016/j.ridd.2006.03.002
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488
DILAVORE PC, 1995, J AUTISM DEV DISORD, V25, P355, DOI 10.1007/BF02179373
Eaves LC, 2004, J AUTISM DEV DISORD, V34, P367, DOI 10.1023/B:JADD.0000037414.33270.a8
Freeman BJ, 1999, J AUTISM DEV DISORD, V29, P379, DOI 10.1023/A:1023078827457
Gabriels RL, 2001, AUTISM, V5, P407, DOI 10.1177/1362361301005004006
GILLBERG C, 1990, J CHILD PSYCHOL PSYC, V31, P921, DOI 10.1111/j.1469-7610.1990.tb00834.x
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Jonsdottir SL, 2007, J AUTISM DEV DISORD, V37, P1361, DOI 10.1007/s10803-006-0282-z
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P606, DOI 10.1007/s10803-007-0427-8
Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
Liss M, 2001, J AUTISM DEV DISORD, V31, P219, DOI 10.1023/A:1010707417274
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
Magiati I, 2001, AUTISM, V5, P399, DOI 10.1177/1362361301005004005
Minshew NJ, 2005, J AUTISM DEV DISORD, V35, P45, DOI 10.1007/s10803-004-1030-x
Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018
Mullen E, 1995, MULLEN SCALES EARLY
Sigman M, 1999, MONOGRAPHS SOC RES C, V64, pv, DOI 10.1111/1540-5834.00001
Sigman M, 2005, J AUTISM DEV DISORD, V35, P15, DOI 10.1007/s10803-004-1027-5
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370
Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
Szatmari P, 2003, J CHILD PSYCHOL PSYC, V44, P520, DOI 10.1111/1469-7610.00141
Trillingsgaard A, 2005, EUR CHILD ADOLES PSY, V14, P65, DOI 10.1007/s00787-005-0433-3
Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
Turner LM, 2006, AUTISM, V10, P243, DOI 10.1177/1362361306063296
Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
Wechsler D., 2004, WECHSLER INTELLIGENC
Wechsler D, 1999, WECHSLER PRESCHOOL P
NR 38
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD JUL
PY 2014
VL 68
IS 5
BP 362
EP 368
DI 10.3109/08039488.2013.846411
PG 7
WC Psychiatry
SC Psychiatry
GA AJ5WN
UT WOS:000337761100012
PM 24199947
ER
PT J
AU Kim, TG
Yao, RQ
Monnell, T
Cho, JH
Vasudevan, A
Koh, A
Kumar, TP
Moon, MH
Datta, D
Bolshakov, VY
Kim, KS
Chung, SM
AF Kim, Tae-Gon
Yao, Ruiqin
Monnell, Travis
Cho, Jun-Hyeong
Vasudevan, Anju
Koh, Alice
Kumar, Peeyush T.
Moon, Minho
Datta, Debkanya
Bolshakov, Vadim Y.
Kim, Kwang-Soo
Chung, Sangmi
TI Efficient Specification of Interneurons from Human Pluripotent Stem
Cells by Dorsoventral and Rostrocaudal Modulation
SO STEM CELLS
LA English
DT Article
DE Pluripotent stem cells; Medial ganglionic eminence; Interneurons;
Differentiation
ID SONIC HEDGEHOG; FUNCTIONAL MATURATION; CORTICAL INTERNEURONS; NEURAL
DEVELOPMENT; GENE-FUNCTION; MOUSE MODEL; HUMAN ES; DIFFERENTIATION;
SCHIZOPHRENIA; EXPRESSION
AB GABAergic interneurons regulate cortical neural networks by providing inhibitory inputs, and their malfunction, resulting in failure to intricately regulate neural circuit balance, is implicated in brain diseases such as Schizophrenia, Autism, and Epilepsy. During early development, GABAergic interneuron progenitors arise from the ventral telencephalic area such as medial ganglionic eminence (MGE) and caudal ganglionic eminence (CGE) by the actions of secreted signaling molecules from nearby organizers, and migrate to their target sites where they form local synaptic connections. In this study, using combinatorial and temporal modulation of developmentally relevant dorsoventral and rostrocaudal signaling pathways (SHH, Wnt, and FGF8), we efficiently generated MGE cells from multiple human pluripotent stem cells. Most importantly, modulation of FGF8/FGF19 signaling efficiently directed MGE versus CGE differentiation. Human MGE cells spontaneously differentiated into Lhx6-expressing GABAergic interneurons and showed migratory properties. These human MGE-derived neurons generated GABA, fired action potentials, and displayed robust GABAergic postsynaptic activity. Transplantation into rodent brains results in well-contained neural grafts enriched with GABAergic interneurons that migrate in the host and mature to express somatostatin or parvalbumin. Thus, we propose that signaling modulation recapitulating normal developmental patterns efficiently generate human GABAergic interneurons. This strategy represents a novel tool in regenerative medicine, developmental studies, disease modeling, bioassay, and drug screening.
C1 [Kim, Tae-Gon; Yao, Ruiqin; Monnell, Travis; Koh, Alice; Moon, Minho; Datta, Debkanya; Kim, Kwang-Soo; Chung, Sangmi] Harvard Univ, Sch Med, McLean Hosp, Mol Neurobiol Lab,Dept Psychiat, Belmont, MA 02178 USA.
[Kim, Tae-Gon; Yao, Ruiqin; Monnell, Travis; Koh, Alice; Moon, Minho; Datta, Debkanya; Kim, Kwang-Soo; Chung, Sangmi] Harvard Univ, Sch Med, McLean Hosp, Program Neurosci, Belmont, MA 02178 USA.
[Kim, Tae-Gon; Yao, Ruiqin; Monnell, Travis; Koh, Alice; Moon, Minho; Datta, Debkanya; Kim, Kwang-Soo; Chung, Sangmi] Harvard Univ, Sch Med, McLean Hosp, Harvard Stem Cell Inst, Belmont, MA 02178 USA.
[Cho, Jun-Hyeong; Bolshakov, Vadim Y.] Harvard Univ, Sch Med, McLean Hosp, Cellular Neurobiol Lab,Dept Psychiat, Belmont, MA 02178 USA.
[Vasudevan, Anju; Kumar, Peeyush T.] Harvard Univ, Sch Med, McLean Hosp, Angiogenesis & Brain Dev Lab,Dept Psychiat, Belmont, MA 02178 USA.
RP Kim, KS (reprint author), Harvard Univ, Sch Med, McLean Hosp, 115 Mill St, Belmont, MA 02178 USA.
EM kskim@mclean.harvard.edu; schung@mclean.harvard.edu
FU NIH [NS079977, MH048866, MH087903, NS070577]; Harvard Stem Cell
Institute
FX We thank Dr. Pachnis for kindly providing us with anti-Lhx6 antibodies.
This study was supported by NIH grants (NS079977, MH048866, MH087903,
and NS070577) and Harvard Stem Cell Institute Seed Grant.
CR Aguilar-Valles A, 2011, PSYCHONEUROENDOCRINO, V36, P634, DOI 10.1016/j.psyneuen.2010.09.006
Alvarez-Dolado M, 2006, J NEUROSCI, V26, P7380, DOI 10.1523/JNEUROSCI.1540-06.2006
Aoto K, 2002, DEV BIOL, V251, P320, DOI 10.1006/dbio.2002.0811
Arber CE, 2013, FRONT CELL NEUROSCI, P7
Baraban SC, 2009, P NATL ACAD SCI USA, V106, P15472, DOI 10.1073/pnas.0900141106
Bellin M, 2012, NAT REV MOL CELL BIO, V13, P713, DOI 10.1038/nrm3448
Borello U, 2008, NEURAL DEV, V3, DOI 10.1186/1749-8104-3-17
Braz JM, 2012, NEURON, V74, P663, DOI 10.1016/j.neuron.2012.02.033
Brennand KJ, 2011, NATURE, V473, P221, DOI 10.1038/nature09915
Cambray S, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1817
Castiglioni V, 2012, NEUROBIOL DIS, V46, P30, DOI 10.1016/j.nbd.2011.12.032
Chambers SM, 2009, NAT BIOTECHNOL, V27, P275, DOI 10.1038/nbt.1529
Chiang C, 1996, NATURE, V383, P407, DOI 10.1038/383407a0
Chung S, 2011, P NATL ACAD SCI USA, V108, P9703, DOI 10.1073/pnas.1016443108
Chung S, 2009, CELL STEM CELL, V5, P646, DOI 10.1016/j.stem.2009.09.015
Danjo T, 2011, J NEUROSCI, V31, P1919, DOI 10.1523/JNEUROSCI.5128-10.2011
Egawa N, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004052
Flames N, 2007, J NEUROSCI, V27, P9682, DOI 10.1523/JNEUROSCI.2750-07.2007
Fuccillo M, 2004, DEVELOPMENT, V131, P5031, DOI 10.1242/dev.01349
Fukuchi-Shimogori T, 2001, SCIENCE, V294, P1071, DOI 10.1126/science.1064252
Garel S, 2003, DEVELOPMENT, V130, P1903, DOI 10.1242/dev.00416
Gilman SR, 2012, NAT NEUROSCI, V15, P1723, DOI 10.1038/nn.3261
Gimeno L, 2007, DEV DYNAM, V236, P2285, DOI 10.1002/dvdy.21237
Gulacsi A, 2006, CEREB CORTEX S1, pi89, DOI DOI 10.1093/CERCOR/BHK018
Gunhaga L, 2003, NAT NEUROSCI, V6, P701, DOI 10.1038/nn1068
Gunhaga L, 2000, DEVELOPMENT, V127, P3283
Hebert JM, 2008, NAT REV NEUROSCI, V9, P678, DOI 10.1038/nrn2463
Houart C, 2002, NEURON, V35, P255, DOI 10.1016/S0896-6273(02)00751-1
Hu BY, 2009, NAT PROTOC, V4, P1614, DOI 10.1038/nprot.2009.186
Ishibashi M, 2002, DEVELOPMENT, V129, P4807
Johnson MA, 2007, J NEUROSCI, V27, P3069, DOI 10.1523/JNEUROSCI.4562-06.2007
Krencik R, 2011, NAT BIOTECHNOL, V29, P528, DOI 10.1038/nbt.1877
Kriks S, 2011, NATURE, V480, P547, DOI 10.1038/nature10648
Lee G, 2012, NAT BIOTECHNOL, V30, P1244, DOI 10.1038/nbt.2435
Li Q, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006354
Li XJ, 2009, DEVELOPMENT, V136, P4055, DOI 10.1242/dev.036624
Lin MY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023356
Liodis P, 2007, J NEUROSCI, V27, P3078, DOI 10.1523/JNEUROSCI.3055-06.2007
Liu Y, 2013, NAT BIOTECHNOL, V31, P440, DOI 10.1038/nbt.2565
Ma T, 2013, NAT NEUROSCI, V16, P1588, DOI 10.1038/nn.3536
Mariani J, 2012, P NATL ACAD SCI USA, V109, P12770, DOI 10.1073/pnas.1202944109
Maroof AM, 2013, CELL STEM CELL, V12, P559, DOI 10.1016/j.stem.2013.04.008
Martinez-Cerdeno V, 2010, CELL STEM CELL, V6, P238, DOI 10.1016/j.stem.2010.01.004
Matsui T., 2012, EXP NEUROL
Nicholas CR, 2013, CELL STEM CELL, V12, P573, DOI 10.1016/j.stem.2013.04.005
Nordstrom U, 2002, NAT NEUROSCI, V5, P525, DOI 10.1038/nn854
Piper M, 2012, PSYCHIAT CLIN N AM, V35, P571, DOI 10.1016/j.psc.2012.06.002
Rallu M, 2002, DEVELOPMENT, V129, P4963
Ruiz i Altaba A, 2002, NAT REV NEUROSCI, V3, P24, DOI DOI 10.1038/NRN704
Sussel L, 1999, DEVELOPMENT, V126, P3359
Tamamaki N, 2003, J COMP NEUROL, V467, P60, DOI 10.1002/cne.10905
Wang S, 2013, CELL STEM CELL, V12, P252, DOI 10.1016/j.stem.2012.12.002
Wichterle H, 1999, NAT NEUROSCI, V2, P461, DOI 10.1038/8131
Wonders CP, 2006, NAT REV NEUROSCI, V7, P687, DOI 10.1038/nrn1954
Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
NR 55
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1066-5099
EI 1549-4918
J9 STEM CELLS
JI Stem Cells
PD JUL
PY 2014
VL 32
IS 7
BP 1789
EP 1804
DI 10.1002/stem.1704
PG 16
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology;
Oncology; Cell Biology; Hematology
SC Cell Biology; Biotechnology & Applied Microbiology; Oncology; Hematology
GA AJ6FI
UT WOS:000337785200009
PM 24648391
ER
PT J
AU Levenson, D
AF Levenson, Deborah
TI NF1 PATIENTS' AUTISTIC TRAITS FALL SHORT OF AUTISM SPECTRUM DISORDERS
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUL
PY 2014
VL 164
IS 7
DI 10.1002/ajmg.a.36645
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ4HB
UT WOS:000337633300003
ER
PT J
AU Guilherme, RS
Soares, KC
Simioni, M
Vieira, TP
Gil-da-Silva-Lopes, VL
Kim, CA
Brunoni, D
Spinner, NB
Conlin, LK
Christofolini, DM
Kulikowski, LD
Steiner, CE
Melaragno, MI
AF Guilherme, Roberta Santos
Soares, Karina Cunha
Simioni, Milena
Vieira, Tarsis Paiva
Gil-da-Silva-Lopes, Vera Lucia
Kim, Chong Ae
Brunoni, Decio
Spinner, Nancy Bettina
Conlin, Laura Kathleen
Christofolini, Denise Maria
Kulikowski, Leslie Domenici
Steiner, Carlos Eduardo
Melaragno, Maria Isabel
TI Clinical, cytogenetic, and molecular characterization of six patients
with ring chromosomes 22, including one with concomitant 22q11.2
deletion
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE ring chromosome 22; 22q11; 2 deletion; 22q13 deletion; speech delay and
SNP array
ID SUBTELOMERIC SEQUENCES; AUTISTIC SYNDROME; 22Q13.3; FISH; DISORDERS
AB We report here on six patients with a ring chromosome 22 and the range of cytogenetic and phenotypic features presented by them. Genomic analysis was carried out using classical and molecular cytogenetics, MLPA (Multiplex Ligation-dependent Probe Amplification) and genome-wide SNP-array analysis. The ring was found in all patients, but Patient 6 displayed constitutional mosaicism with a normal cell line. Five patients had deletions in the ring chromosome 22, and in four of them the breakpointsunique for each patientcould be identified by genome-wide SNP-array analysis. One patient presented with a 22q11.2 deletion concomitant with the deletion caused by the ring formation. Common phenotypic features included autism, speech delay and seizures, as previously reported for individuals with r(22) and/or 22q13.3 deletions. Investigation of the genes within the deletions revealed multiple genes related to development of the central nervous system, psychomotor delay, severe language impairment, hypotonia, and autistic symptoms. There was no clear correlation between the severity of clinical features and the size of the deleted segment. This study underscores the variability in ring structure and clinical presentation of the r(22) and adds information to the limited literature on this rare disorder. (c) 2014 Wiley Periodicals, Inc.
C1 [Guilherme, Roberta Santos; Brunoni, Decio; Melaragno, Maria Isabel] Univ Fed Sao Paulo, Div Genet, Dept Morphol & Genet, BR-04023900 Sao Paulo, Brazil.
[Soares, Karina Cunha; Simioni, Milena; Vieira, Tarsis Paiva; Gil-da-Silva-Lopes, Vera Lucia; Steiner, Carlos Eduardo] Univ Estadual Campinas UNICAMP, Dept Med Genet, Campinas, SP, Brazil.
[Kim, Chong Ae] Univ Sao Paulo, Dept Pediat, Inst Crianca HC FMUSP, Sao Paulo, Brazil.
[Spinner, Nancy Bettina; Conlin, Laura Kathleen] Univ Penn, Childrens Hosp Philadelphia, Dept Pathol, Philadelphia, PA 19104 USA.
[Spinner, Nancy Bettina; Conlin, Laura Kathleen] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Christofolini, Denise Maria] ABC, Fac Med, Div Obstet & Gynecol, Sao Paulo, Brazil.
[Kulikowski, Leslie Domenici] Univ Sao Paulo, Dept Pathol, Lab Citogenom, Sao Paulo, Brazil.
RP Guilherme, RS (reprint author), Univ Fed Sao Paulo, Dept Morphol & Genet, Rua Botucatu 740, BR-04023900 Sao Paulo, Brazil.
EM robertaguilherme@hotmail.com
RI Kulikowski, Leslie/F-4524-2012; Vieira, Tarsis/A-2551-2015
OI Kulikowski, Leslie/0000-0003-2236-3956;
FU FAPESP, Brazil [2012/51150-0, 2012/15572-7]
FX Grant sponsor: FAPESP, Brazil; Grant numbers: 2012/51150-0,
2012/15572-7.
CR Anderlid BM, 2002, HUM GENET, V110, P439, DOI 10.1007/s00439-002-0713-7
Assumpcao FB, 1998, J AUTISM DEV DISORD, V28, P253
Baumer A, 1998, HUM MOL GENET, V7, P887, DOI 10.1093/hmg/7.5.887
Cusmano-Ozog K, 2007, AM J MED GENET C, V145C, P393, DOI 10.1002/ajmg.c.30155
De Mas P, 2002, J Med Genet, V39, pe17, DOI 10.1136/jmg.39.4.e17
Delahaye A, 2009, EUR J MED GENET, V52, P328, DOI 10.1016/j.ejmg.2009.05.004
Devriendt K, 1998, J MED GENET, V35, P789, DOI 10.1136/jmg.35.9.789-a
Dhar SU, 2010, AM J MED GENET A, V152A, P573, DOI 10.1002/ajmg.a.33253
FUNDERBURK SJ, 1979, CLIN GENET, V16, P305
Giza J, 2010, J NEUROSCI, V30, P14805, DOI 10.1523/JNEUROSCI.1161-10.2010
Goizet C, 2000, AM J MED GENET, V96, P839, DOI 10.1002/1096-8628(20001204)96:6<839::AID-AJMG29>3.0.CO;2-R
Guilherme RS, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-171
Guilherme RS, 2010, AM J MED GENET A, V152A, P2865, DOI 10.1002/ajmg.a.33689
HUNTER AGW, 1977, CLIN GENET, V12, P239
Ishmael HA, 2003, CLIN GENET, V63, P410, DOI 10.1034/j.1399-0004.2003.00064.x
Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
Jeffries AR, 2005, AM J MED GENET A, V137A, P139, DOI 10.1002/ajmg.a.30780
Kosho T, 2005, GENET COUNSEL, V16, P65
Le Caignec C, 2004, ANN GENET-PARIS, V47, P289, DOI 10.1016/j.anngen.2003.10.005
LEJEUNE J, 1968, ANN GENET-PARIS, V11, P71
Luciani JJ, 2003, J MED GENET, V40, P690, DOI 10.1136/jmg.40.9.690
MacLean JE, 2000, AM J MED GENET, V90, P382, DOI 10.1002/(SICI)1096-8628(20000228)90:5<382::AID-AJMG7>3.0.CO;2-T
NESSLINGER NJ, 1994, AM J HUM GENET, V54, P464
Phelan K, 2012, MOL SYNDROMOL, V2-5, P186, DOI DOI 10.1159/000334260
Prasad C, 2000, CLIN GENET, V57, P103, DOI 10.1034/j.1399-0004.2000.570203.x
Precht KS, 1998, J MED GENET, V35, P939, DOI 10.1136/jmg.35.11.939
RITTER CL, 1990, AM J MED GENET, V35, P14, DOI 10.1002/ajmg.1320350104
Saitta SC, 2004, HUM MOL GENET, V13, P417, DOI 10.1093/hmg/ddh041
Sarasua SM, 2011, J MED GENET, V48, P761, DOI 10.1136/jmedgenet-2011-100225
Sarasua SM, 2013, GENET MED, V31, P144
Schinzel A., 2001, CATALOGUE UNBALANCED
Sovner R, 1996, J INTELL DISABIL RES, V40, P82, DOI 10.1111/j.1365-2788.1996.tb00607.x
Vermeesch JR, 2002, CLIN GENET, V62, P415, DOI 10.1034/j.1399-0004.2002.620511.x
NR 33
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUL
PY 2014
VL 164
IS 7
BP 1659
EP 1665
DI 10.1002/ajmg.a.36512
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ4HB
UT WOS:000337633300010
PM 24700634
ER
PT J
AU Tinker, J
Carbone, PS
Viskochil, D
Mathiesen, A
Ma, KN
Stevenson, DA
AF Tinker, Jade
Carbone, Paul S.
Viskochil, David
Mathiesen, Amber
Ma, Khe-Ni
Stevenson, David A.
TI Screening children with neurofibromatosis type 1 for autism spectrum
disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE neurofibromatosis type 1; autism spectrum disorders; Modified Checklist
for Autism in Toddlers; Childhood Autism Spectrum Test
ID CAST CHILDHOOD ASPERGER; MODIFIED CHECKLIST; BEHAVIORAL-PHENOTYPE;
TODDLERS; ADOLESCENTS; POPULATION; DIAGNOSIS
AB Autism spectrum disorder (ASD) is reported to be increased in neurofibromatosis type 1 (NF1), but it's unknown if ASD screening tools are sensitive and specific for NF1. This study compared the rate at which children with NF1 screen-positive for two ASD screening tools [Modified Checklist for Autism in Toddlers (M-CHAT) and Childhood Autism Spectrum Test (CAST)] to the screen-positive rate of the general population. A retrospective cross-sectional observational design to investigate the association between children with NF1 and at risk status for ASD was used. Medical records of children between 16 months and 11 years of age seen in an NF Clinic were reviewed for an ASD screening questionnaire. There were no statistically significant differences in the screen-positive rate for ASD in NF1 compared to published controls, but mean CAST scores were higher in NF1. (c) 2014 Wiley Periodicals, Inc.
C1 [Tinker, Jade; Carbone, Paul S.; Viskochil, David; Mathiesen, Amber; Ma, Khe-Ni; Stevenson, David A.] Univ Utah, Dept Pediat, Salt Lake City, UT 84132 USA.
RP Stevenson, DA (reprint author), Univ Utah, Div Med Genet, 2C412 SOM, Salt Lake City, UT 84132 USA.
EM david.stevenson@hsc.utah.edu
FU University of Utah Genetic Counseling Master's Program; Thrasher
Research Fund; Department of Defense [W81XWH-11-1-0250]
FX Grant sponsor: University of Utah Genetic Counseling Master's Program;
Grant sponsor: Thrasher Research Fund; Grant sponsor: Department of
Defense; Grant number: DOD Award W81XWH-11-1-0250.
CR Adviento B, 2013, J MED GENET, DOI [10.1136/jmedgeneti-2013-101951, DOI 10.1136/JMEDGENETI-2013-101951]
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Barton B, 2004, DEV MED CHILD NEUROL, V46, P553, DOI 10.1017/S0012162204000921
Boyd KP, 2009, J AM ACAD DERMATOL, V61, P1, DOI 10.1016/j.jaad.2008.12.051
Carbone PS, 2013, J AUTISM DEV DISORD, V43, P964, DOI 10.1007/s10803-012-1640-7
Clements-Stephens AM, 2008, NEUROPSYCHOLOGIA, V46, P690, DOI 10.1016/j.neuropsychologia.2007.09.013
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dilts CV, 1996, J DEV BEHAV PEDIATR, V17, P229
Eaves LC, 2006, AUTISM, V10, P229, DOI 10.1177/1362361306063288
ELDRIDGE R, 1989, AM J DIS CHILD, V143, P833
Garg S, 2013, PEDIATRICS, V132, pE1642, DOI 10.1542/peds.2013-1868
Garg S, 2013, DEV MED CHILD NEUROL, V55, P139, DOI 10.1111/dmcn.12043
GILLBERG C, 1984, J AUTISM DEV DISORD, V14, P1, DOI 10.1007/BF02408551
Huijbregts S, 2010, DEV MED CHILD NEUROL, V52, P620, DOI 10.1111/j.1469-8749.2010.03639.x
Huijbregts SCJ, 2011, BEHAV GENET, V41, P430, DOI 10.1007/s10519-010-9430-5
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kayl AE, 2000, MENT RETARD DEV D R, V6, P117, DOI 10.1002/1098-2779(2000)6:2<117::AID-MRDD5>3.0.CO;2-X
Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
Miller JS, 2011, PEDIATRICS, V127, P866, DOI 10.1542/peds.2010-0136
Nunley KS, 2009, ARCH DERMATOL, V145, P883, DOI 10.1001/archdermatol.2009.169
Ozonoff S, 1999, AM J MED GENET, V89, P45, DOI 10.1002/(SICI)1096-8628(19990326)89:1<45::AID-AJMG9>3.0.CO;2-J
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Robins DL, 2006, J DEV BEHAV PEDIATR, V27, pS111, DOI 10.1097/00004703-200604002-00009
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
Smith T, 1999, CLIN PSYCHOL-SCI PR, V6, P33, DOI 10.1093/clipsy/6.1.33
Thompson HL, 2010, AM J MED GENET A, V152A, P284, DOI 10.1002/ajmg.a.33235
Walsh KS, 2013, DEV MED CHILD NEUROL, V55, P131, DOI 10.1111/dmcn.12038
Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029
Williams PG, 1998, J AUTISM DEV DISORD, V28, P567, DOI 10.1023/A:1026012414193
Zafeiriou DI, 2007, BRAIN DEV-JPN, V29, P257, DOI 10.1016/j.braindev.2006.09.003
NR 33
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUL
PY 2014
VL 164
IS 7
BP 1706
EP 1712
DI 10.1002/ajmg.a.36549
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ4HB
UT WOS:000337633300016
PM 24715629
ER
PT J
AU Andersen, EF
Baldwin, EE
Ellingwood, S
Smith, R
Lamb, AN
AF Andersen, Erica F.
Baldwin, Erin E.
Ellingwood, Sara
Smith, Rosemarie
Lamb, Allen N.
TI Xq28 duplication overlapping the int22h-1/int22h-2 region and including
RAB39B and CLIC2 in a family with intellectual and developmental
disability
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE Xq28 duplication; Xp22.33 deletion; int22h; RAB39B; CLIC2
ID COPY NUMBER VARIANTS; MENTAL-RETARDATION; AUTISM; GENE; MUTATIONS;
PHENOTYPE; DELETION; GTPASES; EXOME; TMLHE
AB Duplications involving terminal Xq28 are a known cause of intellectual disability (ID) in males and in females with unfavorable X-inactivation patterns. Within Xq28, functional disomy of MECP2 causes a severe ID syndrome, however the dosage sensitivity of other Xq28 duplicated genes is less certain. Duplications involving the int22h-1/int22h-2 LCR-flanked region in distal Xq28 have recently been linked to a novel ID-associated phenotype. While evidence for the dosage sensitivity of this region is emerging, the phenotypic contribution of individual genes within the int22h-1/int22h-2-flanked region has yet to be determined. We report a familial case of a novel 774kb Xq28-qter duplication, detected by cytogenomic microarray analysis, that partially overlaps the int22h-1/int22h-2-flanked region. This duplication and a 570kb Xpter-p22.33 loss within the pseudoautosomal region were identified in three siblings, one female and two males, who presented with developmental delays/intellectual disability, mild dysmorphic features and short stature. Although unconfirmed, these results are suggestive of maternal inheritance of a recombinant X. We compare our clinical findings to patients with int22h-1/int22h-2-mediated duplications and discuss the potential pathogenicity of genes within the duplicated region, including those within the shared region of overlap, RAB39B and CLIC2. (c) 2014 Wiley Periodicals, Inc.
C1 [Andersen, Erica F.; Baldwin, Erin E.; Lamb, Allen N.] ARUP Labs, Salt Lake City, UT 84108 USA.
[Andersen, Erica F.; Lamb, Allen N.] Univ Utah, Dept Pathol, Salt Lake City, UT USA.
[Ellingwood, Sara; Smith, Rosemarie] Maine Med Ctr, Div Genet, Dept Pediat, Portland, ME 04102 USA.
RP Andersen, EF (reprint author), ARUP Labs, 500 Chipeta Way, Salt Lake City, UT 84108 USA.
EM erica.f.andersen@aruplab.com
CR Binder G, 2011, HORM RES PAEDIAT, V75, P81, DOI 10.1159/000324105
Casana P, 2012, BRIT J HAEMATOL, V158, P138, DOI 10.1111/j.1365-2141.2012.09092.x
Celestino-Soper PBS, 2011, HUM MOL GENET, V20, P4360, DOI 10.1093/hmg/ddr363
Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
Dulhunty AF, 2011, DRUG METAB REV, V43, P236, DOI 10.3109/03602532.2010.549134
El-Hattab AW, 2011, J MED GENET, V48, P840, DOI 10.1136/jmedgenet-2011-100125
Giannandrea M, 2010, AM J HUM GENET, V86, P185, DOI 10.1016/j.ajhg.2010.01.011
Isrie M, 2012, EUR J MED GENET, V55, P577, DOI 10.1016/j.ejmg.2012.05.005
Lannoy N, 2013, EUR J HUM GENET, V21, P970, DOI 10.1038/ejhg.2012.275
Munns C., 2008, GENEREVIEWS
Nava C, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.102
Ng EL, 2008, BRAIN RES REV, V58, P236, DOI 10.1016/j.brainresrev.2008.04.006
Piton A, 2013, AM J HUM GENET, V93, P368, DOI 10.1016/j.ajhg.2013.06.013
Ramocki MB, 2010, AM J MED GENET A, V152A, P1079, DOI 10.1002/ajmg.a.33184
Sanlaville D, 2009, ORPHANET J RARE DIS, V4, DOI 10.1186/1750-1172-4-4
Stenmark H, 2009, NAT REV MOL CELL BIO, V10, P513, DOI 10.1038/nrm2728
Takano K, 2012, HUM MOL GENET, V21, P4497, DOI 10.1093/hmg/dds292
Van Esch H, 2012, MOL SYNDROMOL, V2, P128, DOI DOI 10.1159/000329580
Van Esch H, 1993, GENEREVIEWS
Vanmarsenille L, 2014, HUM MUTAT, V35, P377, DOI 10.1002/humu.22497
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
NR 21
TC 1
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUL
PY 2014
VL 164
IS 7
BP 1795
EP 1801
DI 10.1002/ajmg.a.36524
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ4HB
UT WOS:000337633300028
PM 24700761
ER
PT J
AU Schwartzberg, ET
Silverman, MJ
AF Schwartzberg, Edward T.
Silverman, Michael J.
TI Music therapy song repertoire for children with autism spectrum
disorder: A descriptive analysis by treatment areas, song types, and
presentation styles
SO ARTS IN PSYCHOTHERAPY
LA English
DT Article
DE Autism; Music therapy; Music; Songs; Repertoire
ID SCERTS MODEL; RESPONSIVENESS; INTERVENTIONS; BEHAVIORS
AB The purpose of this descriptive study was to identify the song types, presentation styles, and song repertoire utilized within specific treatment areas with children with autism spectrum disorder (ASD). The researchers sent surveys to 257 music therapists who worked with children between the ages of birth through 19 years diagnosed with ASD. Ninety-one music therapists participated in the survey, resulting in a 35% return rate. The number of participants responding to each question ranged from 72 to 91. Overall, the majority of respondents indicated they utilized more pre-existing songs, followed by original compositions and lyric replacement (piggyback) songs. However, when asked questions about song types used to address specific treatment areas, respondents indicated they utilized live original compositions across all treatment domains more frequently than live pre-existing and live lyric replacement songs. Developing protocols to choose song types may be helpful for the acceptance of music therapy as an evidence-based treatment modality for children with ASD. Future research is warranted to determine the type of songs most conducive to facilitating improvement in specific treatment areas. Implications for clinical practice, educational preparation, and limitations of this study are provided. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Schwartzberg, Edward T.; Silverman, Michael J.] Univ Minnesota, Minneapolis, MN 55455 USA.
RP Schwartzberg, ET (reprint author), Univ Minnesota, Sch Mus, 100 Ferguson Hall,2106 Fourth St South, Minneapolis, MN 55455 USA.
EM schwa155@umn.edu
CR American Music Therapy Association, 2013, WORKF AN
Autism Society, 2013, AUT DIAGN
Brownell MD, 2002, J MUSIC THER, V39, P117
Buday E. M., 1995, J MUSIC THER, V32, P373
Buysse V., 2006, ZERO 3, V27, P50
Cevasco A. M., 2010, MUSIC THERAPY PERSPE, V28, P37
Finnigan E, 2010, AUTISM, V14, P321, DOI 10.1177/1362361309357747
Gadberry AL, 2011, J MUSIC THER, V48, P74
GIBBONS AC, 1977, J MUSIC THER, V14, P180
Kaplan R. S., 2005, J MUSIC THER, V25, P73
Kern Petra, 2006, J Music Ther, V43, P270
Kern P., 2007, MUSIC THERAPY PERSPE, V25, P43
Kern P, 2007, J AUTISM DEV DISORD, V37, P1264, DOI 10.1007/s10803-006-0272-1
Kim J, 2009, AUTISM, V13, P389, DOI 10.1177/1362361309105660
Kim J, 2008, J AUTISM DEV DISORD, V38, P1758, DOI 10.1007/s10803-008-0566-6
Kogen M. D., 2009, PEDIATRICS, V124, P1395
Lim HA, 2010, J MUSIC THER, V47, P2
Lim HA, 2011, J MUSIC THER, V48, P532
National Autism Center, 2009, NAT STAND PROJ FIND
Pasiali V., 2004, MUSIC THERAPY PERSPE, V22, P11
Register D., 2007, MUSIC THERAPY PERSPE, V25, P25
Reschke-Hernandez AE, 2011, J MUSIC THER, V48, P169
Robb S. L., 2010, J HEALTH PSYCHOL, V20, P1
Schwartzberg ET, 2012, ART PSYCHOTHER, V39, P314, DOI 10.1016/j.aip.2012.05.001
Simpson K, 2010, J DEV PHYS DISABIL, V22, P165, DOI 10.1007/s10882-009-9173-5
Simpson K, 2011, J AUTISM DEV DISORD, V41, P1507, DOI 10.1007/s10803-010-1172-y
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
VanWeeldon K., 2007, MUSIC THERAPY PERSPE, V25, P4
Walworth DD, 2007, J MUSIC THER, V44, P2
Walworth DD, 2009, J MUSIC THER, V46, P204
Whipple J., 2012, MUSIC THERAPY AUTISM, P58
Whipple J, 2004, J MUSIC THER, V41, P90
WIMPORY D, 1995, J AUTISM DEV DISORD, V25, P541, DOI 10.1007/BF02178299
NR 33
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-4556
EI 1873-5878
J9 ART PSYCHOTHER
JI Arts Psychother.
PD JUL
PY 2014
VL 41
IS 3
BP 240
EP 249
DI 10.1016/j.aip.2014.03.007
PG 10
WC Psychology, Clinical; Rehabilitation
SC Psychology; Rehabilitation
GA AJ4QB
UT WOS:000337659800002
ER
PT J
AU Chandler, F
Dissanayake, C
AF Chandler, Felicity
Dissanayake, Cheryl
TI An investigation of the security of caregiver attachment during middle
childhood in children with high-unctioning autistic disorder
SO AUTISM
LA English
DT Article
DE attachment; high-functioning autism; security
ID PERVASIVE DEVELOPMENTAL DISORDERS; PEER ATTACHMENT; YOUNG-CHILDREN;
MOTHER; PARENT; ASSOCIATIONS; METAANALYSIS; ADOLESCENCE; PERCEPTIONS;
BEHAVIORS
AB Previous research has investigated caregiver attachment relationships in children with autism during early childhood, with few differences found from matched control groups. However, little is known of this relationship during middle childhood (ages 8-12 years). In this study, the aim was to establish whether there are differences in the security of attachment in children with high-functioning autism compared to typically developing children. A secondary aim was to establish whether caregivers' perceptions of their child's attachment to them accorded with the children's own reports. Twenty-one children with high-functioning autism and 17 typically developing children were administered the Kerns Security Scale and the Inventory of Parent and Peer Attachment-Revised, and caregivers completed the same questionnaires from the viewpoint of their child. There were no differences between the groups in the children's and parents' reports of attachment security. Parents' and children's reports were moderately correlated on the Kerns Security Scale but were not correlated on the Inventory of Parent and Peer Attachment-Revised. The results indicate that levels of attachment security in children with high-functioning autism are not different from those in typically developing children.
C1 [Chandler, Felicity; Dissanayake, Cheryl] La Trobe Univ, Melbourne, Vic 3086, Australia.
RP Dissanayake, C (reprint author), La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Melbourne, Vic 3086, Australia.
EM c.dissanayake@latrobe.edu.au
CR Ainsworth M. S., 1978, PATTERNS ATTACHMENT
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Ammaniti M, 2000, Attach Hum Dev, V2, P328, DOI 10.1080/14616730010001587
ARMSDEN GC, 1987, J YOUTH ADOLESCENCE, V16, P427, DOI 10.1007/BF02202939
Bakermans-Kranenburg MJ, 2009, ATTACH HUM DEV, V11, P223, DOI 10.1080/14616730902814762
Bakermans-Kranenburg MJ, 2009, BEHAV BRAIN SCI, V32, P22, DOI 10.1017/S0140525X0900003X
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Bauminger N, 2010, J AUTISM DEV DISORD, V40, P751, DOI 10.1007/s10803-009-0928-8
Bowlby J., 1969, ATTACHMENT LOSS ATTA, V1
Bowlby J, 1973, ANXIETY ANGER, V2
Bretherton I., 2005, ATTACHMENT INFANCY A, P13
BRETHERTON I, 1985, MONOGR SOC RES CHILD, V50, P3, DOI 10.2307/3333824
Bretherton I., 1999, HDB ATTACHMENT THEOR, P89, DOI DOI 10.2307/1166187
Brumariu L. E., 2008, J APPL DEV PSYCHOL, V29, P393, DOI [10.1016/j.appdev.2008.06.002, DOI 10.1016/J.APPDEV.2008.06.002]
BUITELAAR JK, 1995, BEHAVIOUR, V132, P319, DOI 10.1163/156853995X00595
Del Giudice M, 2010, CHILD DEV PERSPECT, V4, P97
DeWolff MS, 1997, CHILD DEV, V68, P571, DOI 10.2307/1132107
Dissanayake C, 1996, J CHILD PSYCHOL PSYC, V37, P149, DOI 10.1111/j.1469-7610.1996.tb01386.x
Dissanayake C, 2001, INT REV RES MENT RET, V23, P239
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
George C., 1996, ADULT ATTACHME UNPUB, V3rd
Granot D, 2001, INT J BEHAV DEV, V25, P530
Gullone E, 2005, CLIN PSYCHOL PSYCHOT, V12, P67, DOI 10.1002/cpp.433
Haltigan JD, 2011, J AUTISM DEV DISORD, V41, P962, DOI 10.1007/s10803-010-1107-7
HARTER S, 1982, CHILD DEV, V53, P87, DOI 10.1111/j.1467-8624.1982.tb01295.x
Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8
Kanner L, 1943, NERV CHILD, V2, P217
Kerns K. A., 2008, HDB ATTACHMENT THEOR, P366
Kerns KA, 1996, DEV PSYCHOL, V32, P457, DOI 10.1037/0012-1649.32.3.457
Kerns KA, 2006, SOC DEV, V15, P1, DOI 10.1111/j.1467-9507.2006.00327.x
Kerns KA, 2007, ATTACH HUM DEV, V9, P33, DOI 10.1080/14616730601151441
Kerns KA, 2001, J FAM PSYCHOL, V15, P69, DOI 10.1037//0893-3200.15.1.69
Kerns KA, 2005, ATTACHMENT IN MIDDLE CHILDHOOD, P46
KRAEMER GW, 1992, BEHAV BRAIN SCI, V15, P493, DOI 10.1017/S0140525X00069752
Lieberman M, 1999, CHILD DEV, V70, P202, DOI 10.1111/1467-8624.00015
Lord C., 2002, AUTISM DIAGNOSTIC OB
Main M., 1990, ATTACHMENT PRESCHOOL, P121
Marvin RS, 2008, HDB ATTACHMENT THEOR, P44
Mayseless O, 2005, ATTACHMENT IN MIDDLE CHILDHOOD, P1
Naber FBA, 2007, J AUTISM DEV DISORD, V37, P1123, DOI 10.1007/s10803-006-0255-2
ROGERS SJ, 1991, J AM ACAD CHILD PSY, V30, P483, DOI 10.1097/00004583-199105000-00021
ROGERS SJ, 1993, J AM ACAD CHILD PSY, V32, P1274, DOI 10.1097/00004583-199311000-00023
Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
Rutter M., 1978, AUTISM REAPPRAISAL C, P1
Rutter M., 2003, SCQ SOCIAL COMMUNICA
SIGMAN M, 1984, J AUTISM DEV DISORD, V14, P231, DOI 10.1007/BF02409576
Taylor EL, 2008, ATTACH HUM DEV, V10, P143, DOI 10.1080/14616730802113687
Thompson RA, 2003, DEV PSYCHOPATHOL, V15, P691, DOI 10.1017/S0954579403000348
VAN IJZENDOORN MH, 1992, CHILD DEV, V63, P840, DOI 10.2307/1131237
van IJzendoorn MH, 2010, CHILD DEV PERSPECT, V4, P109
van Laerhoven H, 2004, ACTA PAEDIATR, V93, P830, DOI 10.1080/08035250410026572
Wechsler D, 1999, WECHSLER ABBREVIATED
Willemsen-Swinkels SHN, 2000, J CHILD PSYCHOL PSYC, V41, P759, DOI 10.1111/1469-7610.00663
NR 53
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 485
EP 492
DI 10.1177/1362361313486205
PG 8
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700002
PM 24072664
ER
PT J
AU Mazefsky, CA
Schreiber, DR
Olino, TM
Minshew, NJ
AF Mazefsky, Carla A.
Schreiber, Dana R.
Olino, Thomas M.
Minshew, Nancy J.
TI The association between emotional and behavioral problems and
gastrointestinal symptoms among children with high-functioning autism
SO AUTISM
LA English
DT Article
DE abdominal pain; autism spectrum disorder; behavior; Child Behavior
Checklist; gastrointestinal
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; YOUNG-PEOPLE;
PREVALENCE; INDIVIDUALS; ADOLESCENTS; ASDS
AB This study investigated the association between gastrointestinal symptoms and a broad set of emotional and behavioral concerns in 95 children with high-functioning autism and IQ scores >= 80. Gastrointestinal symptoms were assessed via the Autism Treatment Network's Gastrointestinal Symptom Inventory, and data were gathered on autism symptom severity, adaptive behavior, and multiple internalizing and externalizing problems. The majority (61%) of children had at least one reported gastrointestinal symptom. Emotional and behavioral problems were also common but with a high degree of variability. Children with and without gastrointestinal problems did not differ in autism symptom severity, adaptive behavior, or total internalizing or externalizing problem scores. However, participants with gastrointestinal problems had significantly higher levels of affective problems. This finding is consistent with a small body of research noting a relationship between gastrointestinal problems, irritability, and mood problems in autism spectrum disorder. More research to identify the mechanisms underlying this relationship in autism spectrum disorder is warranted. Future research should include a medical assessment of gastrointestinal concerns, longitudinal design, and participants with a range of autism spectrum disorder severity in order to clarify the directionality of this relationship and to identify factors that may impact heterogeneity in the behavioral manifestation of gastrointestinal concerns.
C1 [Mazefsky, Carla A.; Schreiber, Dana R.; Olino, Thomas M.; Minshew, Nancy J.] Univ Pittsburgh, Pittsburgh, PA 15213 USA.
RP Mazefsky, CA (reprint author), Univ Pittsburgh, Dept Psychiat, 3811 OHara St,Webster Hall,Suite 300, Pittsburgh, PA 15213 USA.
EM mazefskyca@upmc.edu
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Adamson J., 2011, BMC COMPLEM ALTERN M, V11, P1
ALFVEN G, 1993, ACTA PAEDIATR, V82, P484, DOI 10.1111/j.1651-2227.1993.tb12728.x
Autism Treatment Network, 2005, AUT TREATM NETW GI S
Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D
Carr EG, 2007, J AUTISM DEV DISORD, V37, P413, DOI 10.1007/s10803-006-0176-0
Constantino JN, 2005, SOCIAL RESPONSIVENES
Ebesutani C, 2010, J PSYCHOPATHOL BEHAV, V32, P373, DOI 10.1007/s10862-009-9174-9
Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
Internet System for Assessing Autistic Children (ISAAC), 2003, DAT ENTR FORMS TEMPL
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Maenner MJ, 2012, J AUTISM DEV DISORD, V42, P1520, DOI 10.1007/s10803-011-1379-6
Mannion A, 2013, RES AUTISM SPECT DIS, V7, P35, DOI 10.1016/j.rasd.2012.05.002
Mazefsky CA, 2012, PERSPECTIVES LANGUAG, V19, P38
Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
McAtee M, 2004, J POSIT BEHAV INTERV, V6, P148, DOI 10.1177/10983007040060030301
Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8
Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
Saps M, 2009, J PEDIATR-US, V154, P322, DOI 10.1016/j.jpeds.2008.09.047
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a
Wechsler D, 1999, WECHSLER ABBREVIATED
NR 28
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 493
EP 501
DI 10.1177/1362361313485164
PG 9
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700003
PM 24104507
ER
PT J
AU McStay, RL
Dissanayake, C
Scheeren, A
Koot, HM
Begeer, S
AF McStay, Rebecca L.
Dissanayake, Cheryl
Scheeren, Anke
Koot, Hans M.
Begeer, Sander
TI Parenting stress and autism: The role of age, autism severity, quality
of life and problem behaviour of children and adolescents with autism
SO AUTISM
LA English
DT Article
DE age; autism; autism severity; parenting stress; problem behaviour;
quality of life
ID DOUBLE ABCX MODEL; SPECTRUM DISORDERS; INTELLECTUAL DISABILITY;
PRESCHOOL-CHILDREN; SYMPTOM SEVERITY; MENTAL-HEALTH; CHALLENGING
BEHAVIORS; SOCIAL SUPPORT; RISK MARKERS; MOTHERS
AB While stress is a common experience for parents caring for a child with a developmental disability, current measures fail to distinguish between general stress in parents and the demands of parenting and perceptions of parenting skills (parenting stress). This study examined differences in 'parenting stress' reported by parents of children with autism and typically developing children. This study examined the role of child characteristics (age, autism severity, child quality of life and problem behaviour) on parenting stress in 150 parents of cognitively able children and adolescents with autism. The results revealed that child hyperactivity was the only factor significantly related to parenting stress in parents of children with autism, overruling measures of autism severity and child quality of life. This finding indicates the significant influence of problematic behaviours on parenting demands and perceptions of parenting skills in parents of children with autism, over other child characteristics conceived as within the parent's control. Study implications for future research are discussed.
C1 [McStay, Rebecca L.; Dissanayake, Cheryl] La Trobe Univ, Bundoora, Vic 3086, Australia.
[Scheeren, Anke; Koot, Hans M.; Begeer, Sander] Vrije Univ Amsterdam, Amsterdam, Netherlands.
[Begeer, Sander] Univ Sydney, Sydney, NSW 2006, Australia.
RP Begeer, S (reprint author), Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
EM sander.begeer@sydney.edu.au
CR Abidin R. R., 1983, PARENTING STRESS IND
Abidin RR, 1995, PARENTING STRESS IND
American Psychiatric Association, 2013, DIAGN STAT MAN MENT, P461
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Anthony LG, 2005, INFANT CHILD DEV, V14, P133, DOI 10.1002/icd.385
(APA) APA, 2000, DIAGN STAT MAN MENT
Ashford J, 2008, J CHILD PSYCHOL PSYC, V49, P774, DOI 10.1111/j.1469-7610.2008.01889.x
Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268
Bauminger N, 2010, AUTISM RES, V3, P101, DOI 10.1002/aur.131
Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2
Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
Burbidge C, 2010, J INTELL DISABIL RES, V54, P1078, DOI 10.1111/j.1365-2788.2010.01338.x
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2005, SOCIAL RESPONSIVENES
Davies LE, 2008, J INTELL DISABIL RES, V52, P662
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
De Brock A., 1992, NOSI NIJMEEGSE OUDER
DeaterDeckard K, 1996, J FAM PSYCHOL, V10, P45, DOI 10.1037/0893-3200.10.1.45
Dunn LM, 2004, PEABODY PICTURE VOCA
Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
Fitzgerald M, 2002, IRISH J PSYCHOL, V23, P2
Gray DE, 2002, J INTELLECT DEV DIS, V27, P215, DOI 10.1080/1366825021000008639
Graziano PA, 2011, J ABNORM CHILD PSYCH, V39, P1073, DOI 10.1007/s10802-011-9528-0
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Hastings RP, 2001, J AUTISM DEV DISORD, V31, P327, DOI 10.1023/A:1010799320795
Johnston C, 2001, CLIN CHILD FAM PSYCH, V4, P183, DOI 10.1023/A:1017592030434
Kabot S, 2003, PROF PSYCHOL-RES PR, V34, P26, DOI 10.1037/0735-7028.34.1.26
Kazak AE, 1997, J PEDIATR PSYCHOL, V22, P749, DOI 10.1093/jpepsy/22.5.749
KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151
KOESKE GF, 1990, AM J ORTHOPSYCHIAT, V60, P440, DOI 10.1037/h0079164
KONSTANTAREAS MM, 1989, J CHILD PSYCHOL PSYC, V30, P459, DOI 10.1111/j.1469-7610.1989.tb00259.x
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Lounds J, 2007, AM J MENT RETARD, V112, P401, DOI 10.1352/0895-8017(2007)112[401:TACIAA]2.0.CO;2
Lyons AM, 2010, J CHILD FAM STUD, V19, P516, DOI 10.1007/s10826-009-9323-5
Manning MM, 2011, J AUTISM DEV DISORD, V41, P320, DOI 10.1007/s10803-010-1056-1
Matson JL, 2007, RES DEV DISABIL, V28, P567, DOI 10.1016/j.ridd.2006.08.001
McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
Mesman J, 2000, J ABNORM PSYCHOL, V109, P428, DOI 10.1037//0021-843X.109.3.428
MORGAN SB, 1988, J AUTISM DEV DISORD, V18, P263, DOI 10.1007/BF02211952
Oosterlaan J, 2008, DISRUPTIVE BEHAV DIS
ORR RR, 1993, MENT RETARD, V31, P171
Orsmond GI, 2006, AM J MENT RETARD, V111, P121, DOI 10.1352/0895-8017(2006)111[121:MRQAAA]2.0.CO;2
PELHAM WE, 1992, J AM ACAD CHILD PSY, V31, P210, DOI 10.1097/00004583-199203000-00006
Peterson J, 1998, FAM RELAT, V47, P221, DOI 10.2307/584970
Peters-Scheffer N, 2012, RES AUTISM SPECT DIS, V6, P696, DOI 10.1016/j.rasd.2011.10.003
Pisula E, 2010, J AUTISM DEV DISORD, V40, P1485, DOI 10.1007/s10803-010-1001-3
Reiersen Angela M, 2008, Expert Rev Neurother, V8, P657, DOI 10.1586/14737175.8.4.657
Roeyers H., 2011, SRS SCREENINGSLIJST
Saloviita T, 2003, J INTELL DISABIL RES, V47, P300, DOI 10.1046/j.1365-2788.2003.00492.x
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Smith LE, 2008, J AUTISM DEV DISORD, V38, P876, DOI 10.1007/s10803-007-0461-6
Tahmassian K, 2011, INT P ECON DEV RES, V5, P190
Tehee E, 2009, J APPL RES INTELLECT, V22, P34, DOI 10.1111/j.1468-3148.2008.00437.x
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006
NR 59
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 502
EP 510
DI 10.1177/1362361313485163
PG 9
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700004
PM 24104515
ER
PT J
AU Patterson, SY
Elder, L
Gulsrud, A
Kasari, C
AF Patterson, Stephanie Y.
Elder, Lauren
Gulsrud, Amanda
Kasari, Connie
TI The association between parental interaction style and children's joint
engagement in families with toddlers with autism
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; joint engagement; parental directiveness;
parental responsivity; social initiations; toddlers
ID ATTENTION
AB Purpose: This study examines the relationship between parental interaction style (responsive vs directive) and child-initiated joint engagement within caregiver-child interactions with toddlers diagnosed with autism spectrum disorders.
Method: Videotaped interactions of 85 toddler-caregiver dyads were coded for child engagement and both parental responsiveness and directiveness.
Results: Altogether, children spent less than one-third of the interaction jointly engaged. After controlling for child characteristics, parental style was associated with the initiator (child or parent) of joint engagement. Specifically, responsiveness predicted total time in child-initiated joint engagement, while directiveness predicted total time in parent-initiated joint engagement. Children's social behaviours were associated with child-initiated joint engagement.
Discussion: Social initiations are a key target for children with autism spectrum disorders. Results demonstrate that child initiations and global social behaviour ratings are associated with parental responsivity. Responsivity may be a critical factor to facilitate children's initiations.
C1 [Patterson, Stephanie Y.] Univ Calif Los Angeles, Los Angeles, CA 90095 USA.
[Elder, Lauren] Autism Speaks, New York, NY USA.
[Gulsrud, Amanda; Kasari, Connie] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Los Angeles, CA 90095 USA.
RP Patterson, SY (reprint author), Univ Calif Los Angeles, Grad Sch Educ & Informat Studies, Moore Hall,2027,Box 951521, Los Angeles, CA 90095 USA.
EM sypatterson@ucla.edu
CR Adamson LB, 2004, CHILD DEV, V75, P1171, DOI 10.1111/j.1467-8624.2004.00732.x
Adamson LB, 2001, J APPL DEV PSYCHOL, V22, P439, DOI 10.1016/S0193-3973(01)00089-2
Adamson LB, 2009, J AUTISM DEV DISORD, V39, P84, DOI 10.1007/s10803-008-0601-7
Fey ME, 2006, J SPEECH LANG HEAR R, V49, P526, DOI 10.1044/1092-4388(2006/039)
Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Lord C., 1999, AUTISM DIAGNOSTIC OB
Mahoney G, 2003, TOPICS EARLY CHILD S, V23, P74, DOI DOI 10.1177/02711214030230020301
Mullen E, 1995, MULLEN SCALES EARLY
Ruble LA, 2007, J AUTISM DEV DISORD, V37, P1457, DOI 10.1007/s10803-006-0222-y
Tomasello M., 2001, LANG ACQUIS, P133
Warren SF, 2007, MENT RETARD DEV D R, V13, P330, DOI 10.1002/mrdd.20177
NR 12
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 511
EP 518
DI 10.1177/1362361313483595
PG 8
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700005
PM 24104518
ER
PT J
AU Freuler, AC
Baranek, GT
Tashjian, C
Watson, LR
Crais, ER
Turner-Brown, LM
AF Freuler, Ashley C.
Baranek, Grace T.
Tashjian, Christene
Watson, Linda R.
Crais, Elizabeth R.
Turner-Brown, Lauren M.
TI Parent reflections of experiences of participating in a randomized
controlled trial of a behavioral intervention for infants at risk of
autism spectrum disorders
SO AUTISM
LA English
DT Article
DE autism; early intervention; parent experience; qualitative
ID CHILDREN; STRESS; DIAGNOSIS; MOTHERS
AB Background: Despite the mounting evidence of efficacy of early intervention for children with autism spectrum disorders, there is little research that considers the various perceptions and resources with which parents respond to the pressures and opportunities associated with participation in early intervention. Research is particularly lacking surrounding experiences of parents with infants who are at risk of autism spectrum disorders but do not (yet) have a diagnosed condition.
Objectives: This qualitative study aimed to explore the experiences of caregivers following their participation in a randomized controlled trial of Adapted Responsive Teaching, a parent-infant relationship-focused intervention for infants at risk of autism spectrum disorders in a community sample. Parents were randomized into either the treatment group, in which they participated in the Adapted Responsive Teaching intervention, or the community services group, in which they were provided with information regarding local early intervention services and were encouraged, but not required to, seek community services as part of their inclusion in the randomized controlled trial.
Methods: Semistructured interviews were conducted with families following the completion of the randomized controlled trial. Participants consisted of 13 mothers and 4 fathers. Five dyads were interviewed together for a total of 14 families. Child ages ranged from 39 to 46 months at the time of interview. Analysis was conducted on 14 interviews from 10 families who were randomized into the treatment group and 4 families randomized into the community services group. Analysis was informed by a thematic analysis approach, which involved a systematic process of coding and theme identification both across and within groups.
Results: Themes that emerged across groups included Working against all odds, Value of the personal relationship, Getting the ball rolling, and Getting dad on board. One broad theme represented the data within the groups: Win-win (Adapted Responsive Teaching group) and Navigating amidst ambiguity (community services group).
Conclusions: This study illuminates the personal experiences and contextual influences affecting families who are participating in the randomized controlled trial through early identification of "risk" status for autism spectrum disorders in their infants. Insights gained from these interviews may serve to refine and enhance intervention models and to enhance early intervention services for families.
C1 [Freuler, Ashley C.; Baranek, Grace T.; Tashjian, Christene; Watson, Linda R.; Crais, Elizabeth R.; Turner-Brown, Lauren M.] Univ N Carolina, Chapel Hill, NC 27599 USA.
RP Freuler, AC (reprint author), Univ N Carolina, Div Occupat Sci & Occupat Therapy, Dept Allied Hlth Sci, Bondurant Hall,CB 7122, Chapel Hill, NC 27599 USA.
EM afreuler@med.unc.edu
CR Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
Baranek GT, 2003, 1 YEAR INVENTORY FYI
Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2
Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
DeGrace BW, 2004, AM J OCCUP THER, V58, P543
Dumville JC, 2006, CONTEMP CLIN TRIALS, V27, P1, DOI 10.1016/j.cct.2005.08.003
Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
Hsieh HF, 2005, QUAL HEALTH RES, V15, P1277, DOI 10.1177/1049732305276687
Hutton A. M., 2005, FOCUS AUTISM OTHER D, V20, P180, DOI [10.1177/10883576050200030601, DOI 10.1177/10883576050200030601]
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Liptak Gregory S, 2006, J Pediatr Health Care, V20, P245, DOI 10.1016/j.pedhc.2005.12.008
Mahoney G., 2007, AUTISM DEV DELAYS YO
Mansell W, 2004, AUTISM, V8, P387, DOI 10.1177/1362361304045213
Morse J. M., 1995, QUALITATIVE RES METH, V2nd
Myers BJ, 2009, RES AUTISM SPECT DIS, V3, P670, DOI 10.1016/j.rasd.2009.01.004
Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
Osborne LA, 2009, EXCEPT CHILDREN, V76, P54
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Reznick JS, 2007, J AUTISM DEV DISORD, V37, P1691, DOI 10.1007/s10803-006-0303-y
Turner-Brown LM, 2013, AUTISM, V17, P527, DOI 10.1177/1362361312439633
Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
Zhang Y., 2009, APPL SOCIAL RES METH
NR 25
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 519
EP 528
DI 10.1177/1362361313483928
PG 10
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700006
PM 24104508
ER
PT J
AU Engelhardt, CR
Mazurek, MO
AF Engelhardt, Christopher R.
Mazurek, Micah O.
TI Video game access, parental rules, and problem behavior: A study of boys
with autism spectrum disorder
SO AUTISM
LA English
DT Article
DE autism; in-room media; oppositional behavior; video game rules; video
games
ID MEDIA USE; CHILDREN; TELEVISION; ADOLESCENTS; BEDROOM; OVERWEIGHT;
HABITS; RISK; TIME; AGE
AB Environmental correlates of problem behavior among individuals with autism spectrum disorder remain relatively understudied. The current study examined the contribution of in-room (i.e. bedroom) access to a video game console as one potential correlate of problem behavior among a sample of 169 boys with autism spectrum disorder (ranging from 8 to 18 years of age). Parents of these children reported on (1) whether they had specific rules regulating their child's video game use, (2) whether their child had in-room access to a variety of screen-based media devices (television, computer, and video game console), and (3) their child's oppositional behaviors. Multivariate regression models showed that in-room access to a video game console predicted oppositional behavior while controlling for in-room access to other media devices (computer and television) and relevant variables (e. g. average number of video game hours played per day). Additionally, the association between in-room access to a video game console and oppositional behavior was particularly large when parents reported no rules on their child's video game use. The current findings indicate that both access and parental rules regarding video games warrant future experimental and longitudinal research as they relate to problem behavior in boys with autism spectrum disorder.
C1 [Engelhardt, Christopher R.; Mazurek, Micah O.] Univ Missouri, Columbia, MO 65203 USA.
RP Engelhardt, CR (reprint author), Univ Missouri, Dept Psychol Sci, 210 McAlester Hall, Columbia, MO 65203 USA.
EM cre8f9@mail.missouri.edu
CR Adachi-Mejia AM, 2007, INT J OBESITY, V31, P644, DOI 10.1038/sj.ijo.0803455
Bar-on ME, 2001, PEDIATRICS, V107, P423
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Borzekowski DLG, 2005, ARCH PEDIAT ADOL MED, V159, P607, DOI 10.1001/archpedi.159.7.607
Chan Philip A, 2006, Ann Gen Psychiatry, V5, P16, DOI 10.1186/1744-859X-5-16
Christakis DA, 2004, J PEDIATR-US, V145, P652, DOI 10.1016/j.jpeds.2005.06.078
Dennison BA, 2002, PEDIATRICS, V109, P1028, DOI 10.1542/peds.109.6.1028
DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gentile DA, 2011, CHILD DEV PERSPECT, V5, P75, DOI 10.1111/j.1750-8606.2011.00159.x
Gentile DA, 2004, J ADOLESCENCE, V27, P5, DOI 10.1016/j.adolescence.2003.10.002
Gentile DA, 2002, J APPL DEV PSYCHOL, V23, P157, DOI 10.1016/S0193-3973(02)00102-8
Gentile DA, 2012, PSYCHOL POPULAR MEDI, V1, P62, DOI DOI 10.1037/A0026969
LARSON R, 1995, J YOUTH ADOLESCENCE, V24, P535, DOI 10.1007/BF01537055
Livingstone S., 2002, YOUNG PEOPLE NEW MED
Lopata C, 2010, J ABNORM CHILD PSYCH, V38, P765, DOI 10.1007/s10802-010-9406-1
Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P1, DOI 10.1016/j.rasd.2011.08.001
Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
Mazurek MO, 2012, J AUTISM DEV DISORD, V42, P1757, DOI 10.1007/s10803-011-1413-8
Mazurek MO, 2013, RES AUTISM SPECT DIS, V7, P316, DOI 10.1016/j.rasd.2012.09.008
Mazurek MO, 2013, J AUTISM DEV DISORD, V43, P1258, DOI 10.1007/s10803-012-1659-9
Nally B, 2000, AUTISM, V4, P331, DOI DOI 10.1177/1362361300004003008
Olson CK, 2007, J ADOLESCENT HEALTH, V41, P77, DOI 10.1016/j.jadohealth.2007.01.001
Orsmond GI, 2011, AUTISM, V15, P579, DOI 10.1177/1362361310386503
Osborne LA, 2009, EXCEPT CHILDREN, V76, P54
Patterson G. R., 1982, COERCIVE FAMILY PROC
Patterson GR, 2002, ANTISOCIAL BEHAV CHI, P25, DOI DOI 10.1037/10468-002
Pottie CG, 2009, J PEDIATR PSYCHOL, V34, P419, DOI 10.1093/jpepsy/jsn094
Rideout V. J., 2010, GENERATION M2 MEDIA
Roberts D., 2005, GENERATION M MEDIA L
Roberts DF, 2000, J ADOLESCENT HEALTH, V27, P8, DOI 10.1016/S1054-139X(00)00128-2
Roberts DF, 2008, FUTURE CHILD, V18, P11
Shane HC, 2008, J AUTISM DEV DISORD, V38, P1499, DOI 10.1007/s10803-007-0527-5
Strasburger VC, 1999, PEDIATRICS, V103, P129, DOI 10.1542/peds.103.1.129
Truglio RT, 1996, J APPL DEV PSYCHOL, V17, P475, DOI 10.1016/S0193-3973(96)90012-X
Van den Bulck J, 2004, SLEEP, V27, P101
Wolraich ML, 2003, J PEDIATR PSYCHOL, V28, P559, DOI 10.1093/jpepsy/jsg046
Wolraich ML, 1998, J DEV BEHAV PEDIATR, V19, P162, DOI 10.1097/00004703-199806000-00003
Zimmerman FJ, 2005, ARCH PEDIAT ADOL MED, V159, P619, DOI 10.1001/archpedi.159.7.619
NR 40
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 529
EP 537
DI 10.1177/1362361313482053
PG 9
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700007
PM 24104510
ER
PT J
AU O'Nions, E
Viding, E
Greven, CU
Ronald, A
Happe, F
AF O'Nions, Elizabeth
Viding, Essi
Greven, Corina U.
Ronald, Angelica
Happe, Francesca
TI Pathological demand avoidance: Exploring the behavioural profile
SO AUTISM
LA English
DT Article
DE atypical autism; autism spectrum disorder; conduct problems and
callous-unemotional traits; pathological demand avoidance; phenotype
ID CONDUCT PROBLEMS; CHILDREN; DISORDERS; CHILDHOOD; AUTISM;
PSYCHOPATHOLOGY; ADHD; TWIN
AB 'Pathological Demand Avoidance' is a term increasingly used by practitioners in the United Kingdom. It was coined to describe a profile of obsessive resistance to everyday demands and requests, with a tendency to resort to 'socially manipulative' behaviour, including outrageous or embarrassing acts. Pathological demand avoidance is thought to share aspects of social impairment with autism spectrum disorders, but autism spectrum disorder-appropriate strategies, such as routine and repetition, are described as unhelpful. Outrageous acts and lack of concern for their effects draw parallels with conduct problems and callous-unemotional traits. However, reward-based techniques, effective with conduct problems and callous-unemotional traits, seem not to work in pathological demand avoidance. Despite increasing interest and controversy over the pathological demand avoidance label, there is only one published study to date. We present the first systematic comparison of the behavioural profile of children receiving the term pathological demand avoidance (N = 25) to children with autism spectrum disorders (N = 39) or conduct problems and callous-unemotional traits (N = 28), using parent-report indices of psychopathology. The pathological demand avoidance group displayed comparable levels of autistic traits and peer problems to the autism spectrum disorders group and anti-social traits approaching those seen in the conduct problems and callous-unemotional traits group. Emotional symptoms in pathological demand avoidance exceeded both comparison groups. Findings highlight the extreme behavioural impairment associated with pathological demand avoidance and the need to explore whether behavioural overlap reflects a similar neurocognitive basis to existing groups.
C1 [O'Nions, Elizabeth; Viding, Essi; Greven, Corina U.; Happe, Francesca] Kings Coll London, London SE5 8AF, England.
[Viding, Essi] UCL, London WC1E 6BT, England.
[Greven, Corina U.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Ronald, Angelica] Birkbeck, London, England.
RP O'Nions, E (reprint author), Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat, Denmark Hill, London SE5 8AF, England.
EM elizabeth.onions@kcl.ac.uk
RI Ronald, Angelica/C-7812-2009
OI Ronald, Angelica/0000-0002-9576-2176
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
American Psychiatric Association, 1980, DIAGN STAT MAN MENT
Budhani S, 2005, J CHILD PSYCHOL PSYC, V46, P972, DOI 10.1111/j.1469-7610.2004.00398.x
Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
Frick P., 2001, ANTISOCIAL PROCESS S
Frick PJ, 2003, J ABNORM CHILD PSYCH, V31, P457, DOI 10.1023/A:1023899703866
Frick PJ, 2010, PROPOSAL DSM 5 CHILD, P1
Frick PJ, 2009, DEV PSYCHOPATHOL, V21, P1111, DOI 10.1017/S0954579409990071
FRITH U, 1991, TRENDS NEUROSCI, V14, P433, DOI 10.1016/0166-2236(91)90041-R
Goodman R, 2000, J CHILD PSYCHOL PSYC, V41, P645, DOI 10.1111/j.1469-7610.2000.tb02345.x
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Greven CU, 2011, J ABNORM CHILD PSYCH, V39, P265, DOI 10.1007/s10802-010-9451-9
Hanscombe KB, 2010, LEARN INDIVID DIFFER, V20, P549, DOI 10.1016/j.lindif.2010.06.005
Jones AP, 2011, J CHILD PSYCHOL PSYC, V11, P1188
Kunce L, 1998, ASPERGER SYNDROME HI, P227
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
Matthys W, 1999, J AM ACAD CHILD PSY, V38, P311, DOI 10.1097/00004583-199903000-00019
Newson E, 2003, ARCH DIS CHILD, V88, P595, DOI 10.1136/adc.88.7.595
OBrien BS, 1996, J ABNORM CHILD PSYCH, V24, P223, DOI 10.1007/BF01441486
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
Taylor S., 2000, CLIN CHILD PSYCHOL P, V5, P23, DOI 10.1177/1359104500005001004
Viding E, 2008, Q J EXP PSYCHOL, V61, P171, DOI 10.1080/17470210701508889
Weil AP, 1953, PSYCHOANAL STUD CHIL, V8, P271
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
Wing L, 1991, AUTISM ASPERGER SYND, P93, DOI DOI 10.1017/CB09780511526770.003
WOLFF S, 1979, J CHILD PSYCHOL PSYC, V20, P29, DOI 10.1111/j.1469-7610.1979.tb01704.x
World Health Organization, 1992, INT CLASS DIS
NR 29
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 538
EP 544
DI 10.1177/1362361313481861
PG 7
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700008
PM 24104509
ER
PT J
AU Parr, AD
Hunter, ST
AF Parr, Alissa D.
Hunter, Samuel T.
TI Enhancing work outcomes of employees with autism spectrum disorder
through leadership: Leadership for employees with autism spectrum
disorder
SO AUTISM
LA English
DT Article
DE autism; job attitudes; leadership; performance
ID TRANSFORMATIONAL LEADERSHIP; CHARISMATIC LEADERSHIP; TRANSACTIONAL
LEADERSHIP; TASK PREFERENCES; ADULTS; EMPLOYMENT; CONSEQUENCES;
ORGANIZATION; METAANALYSIS; ANTECEDENTS
AB The focus of this study was to identify leader behaviors that elicit successful engagement of employees with autism spectrum disorder, a population that is powerfully emerging into the workplace. The ultimate goal was to improve the quality of life of employees with autism spectrum disorder by facilitating an environment leading to their success. Through a series of interviews with 54 employees with autism spectrum disorder, results indicated that leadership has a great effect on employee attitudes and performance, and that the notion of leadership preferences is quite complex culminating in several important behaviors rather than one superior leadership theory. Implications and future research directions are discussed.
C1 [Parr, Alissa D.; Hunter, Samuel T.] Penn State Univ, University Pk, PA 16802 USA.
RP Parr, AD (reprint author), Penn State Univ, 506 Keller Bldg, University Pk, PA 16802 USA.
EM aparr@psu.edu
CR ALLEN NJ, 1990, J OCCUP PSYCHOL, V63, P1
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Avolio BJ, 2009, ANNU REV PSYCHOL, V60, P421, DOI 10.1146/annurev.psych.60.110707.163621
Barling J., 2010, APA HDB IND ORG PSYC, P183
Bass B. M., 1985, LEADERSHIP PERFORMAN
Bass BM, 1997, AM PSYCHOL, V52, P130, DOI 10.1037/0003-066X.52.2.130
Bass BM, 1990, TRANSFORMATION LEADE
Bennett K, 2010, FOCUS AUTISM DEV DIS, V25, P173, DOI 10.1177/1088357610371636
Brown DJ, 2005, LEADERSHIP QUART, V16, P245, DOI 10.1016/j.leaqua.2005.01.003
Burke RV, 2010, RES DEV DISABIL, V31, P1223, DOI 10.1016/j.ridd.2010.07.023
Burns J, 1978, LEADERSHIP
BURT DB, 1991, J AUTISM DEV DISORD, V21, P237, DOI 10.1007/BF02284763
Cammann C., 1979, MICHIGAN ORG A UNPUB
DeGroot T, 2000, CAN J ADM SCI, V17, P356
Dulebohn JH, 2012, J MANAGE, V38, P1715, DOI 10.1177/0149206311415280
Fleishman EA, 1953, J APPL PSYCHOL, V37, P1, DOI 10.1037/h0056314
Greer T, 2006, J APPL PSYCHOL, V91, P1351, DOI 10.1037/0021-9010.91.6.1351
Hagner D, 2005, FOCUS AUTISM OTHER D, V20, P91, DOI DOI 10.1177/10883576050200020501
Hendricks D, 2010, J VOCATIONAL REHABIL, V32, P125, DOI DOI 10.3233/JVR-2010-0502
Hillier A, 2007, CAREER DEV EXCEPTION, V30, P35, DOI DOI 10.1177/08857288070300010501
HOWELL JM, 1993, J APPL PSYCHOL, V78, P891, DOI 10.1037/0021-9010.78.6.891
Howell JM, 2005, ACAD MANAGE REV, V30, P96
Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
Hunt JG, 1999, LEADERSHIP QUART, V10, P129, DOI 10.1016/S1048-9843(99)00015-6
Hunter ST, 2007, LEADERSHIP QUART, V18, P435, DOI 10.1016/j.leaqua.2007.07.001
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
Judge TA, 2004, J APPL PSYCHOL, V89, P36, DOI 10.1037/0021-9010.89.1.36
Judge TA, 2004, J APPL PSYCHOL, V89, P755, DOI 10.1037/0021-9010.89.5.755
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Lattimore LP, 2003, BEHAV INTERVENT, V18, P161, DOI 10.1002/bin.138
Lattimore LP, 2002, J APPL BEHAV ANAL, V35, P85, DOI 10.1901/jaba.2002.35-85
Lawer L, 2009, J AUTISM DEV DISORD, V39, P487, DOI 10.1007/s10803-008-0649-4
Luthans F., 2003, POSITIVE ORG SCHOLAR, P241
Mank D, 1997, MENT RETARD, V35, P185, DOI 10.1352/0047-6765(1997)035<0185:AOTTOS>2.0.CO;2
Padilla A, 2007, LEADERSHIP QUART, V18, P176, DOI 10.1016/j.leaqua.2007.03.001
Rafferty AE, 2004, LEADERSHIP QUART, V15, P329, DOI 10.1016/j.leaqua.2004.02.009
Schaufeli WB, 2006, EDUC PSYCHOL MEAS, V66, P701, DOI 10.1177/0013164405282471
Schleicher DJ, 2010, AM PSYCHOL ASS HDB I, P183
Smith M, 1995, GUIDE SUCCESSFUL EMP
Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027
Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
STOGDILL RM, 1950, PSYCHOL BULL, V47, P1, DOI 10.1037/h0053857
Unger DD, 2003, FOCUS AUTISM OTHER D, V17, P2
Volker MA, 2008, SCHOOL PSYCHOL QUART, V23, P258, DOI 10.1037/1045-3830.23.2.258
Walumbwa FO, 2008, J MANAGE, V34, P89, DOI 10.1177/0149206307308913
WAYNE SJ, 1990, J APPL PSYCHOL, V75, P487, DOI 10.1037//0021-9010.75.5.487
Yukl G, 1999, LEADERSHIP QUART, V10, P285, DOI 10.1016/S1048-9843(99)00013-2
Yukl G. A., 2010, LEADERSHIP ORG
NR 48
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 545
EP 554
DI 10.1177/1362361313483020
PG 10
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700009
PM 23886575
ER
PT J
AU Swanson, AR
Warren, ZE
Stone, WL
Vehorn, AC
Dohrmann, E
Humberd, Q
AF Swanson, Amy R.
Warren, Zachary E.
Stone, Wendy L.
Vehorn, Alison C.
Dohrmann, Elizabeth
Humberd, Quentin
TI The diagnosis of autism in community pediatric settings: Does advanced
training facilitate practice change?
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; diagnosis; screening
ID SPECTRUM DISORDERS; MODIFIED CHECKLIST; CHILDREN; TODDLERS; STAT; AGE
AB The increased prevalence of autism spectrum disorder and documented benefits of early intensive intervention have created a need for flexible systems for determining eligibility for autism-specific services. This study evaluated the effectiveness of a training program designed to enhance autism spectrum disorder identification and assessment within community pediatric settings across the state. Twenty-seven pediatric providers participated in regional trainings across a 3.5-year period. Trainings provided clinicians with strategies for conducting relatively brief within-practice interactive assessments following positive autism spectrum disorder screenings. Program evaluation was measured approximately 1.5 years following training through (a) clinician self-reports of practice change and (b) blind diagnostic verification of a subset of children assessed. Pediatric providers participating in the training reported significant changes in screening and consultation practices following training, with a reported 85% increase in diagnostic identification of children with autism spectrum disorder within their own practice setting. In addition, substantial agreement (86%-93%) was found between pediatrician diagnostic judgments and independent, comprehensive blinded diagnostic evaluations. Collaborative training methods that allow autism spectrum disorder identification within broader community pediatric settings may help translate enhanced screening initiatives into more effective and efficient diagnosis and treatment.
C1 [Swanson, Amy R.; Warren, Zachary E.; Vehorn, Alison C.; Dohrmann, Elizabeth] Vanderbilt Univ, Nashville, TN 37203 USA.
[Stone, Wendy L.] Univ Washington, Seattle, WA 98195 USA.
[Humberd, Quentin] Blanchfield Army Community Hosp, Fort Campbell, KY 42223 USA.
RP Warren, ZE (reprint author), Vanderbilt Univ, Dept Pediat Psychiat & Special Educ, PMB 74,230 Appleton Pl, Nashville, TN 37203 USA.
EM zachary.warren@vanderbilt.edu
CR Al-Qabandi M, 2011, PEDIATRICS, V128, P211
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bailey K, 2008, AUTISM SPECTRUM DISO, P300
Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
Belamarich PF, 2006, PEDIATRICS, V118, pE964, DOI 10.1542/peds.2006-0652
Brogan CA, 2003, AUTISM, V7, P31, DOI 10.1177/1362361303007001004
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
Foss-Feig J, 2007, INT M AUT RES IMFAR
Goin-Kochel RP, 2006, AUTISM, V10, P439, DOI 10.1177/1362361306066601
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2006, SOCIAL COMMUNICATION, P35
Marvin RS, 1996, J CLIN CHILD PSYCHOL, V25, P436, DOI 10.1207/s15374424jccp2504_8
Mullen E, 1995, MULLEN SCALES EARLY
Nicholas JS, 2009, ANN EPIDEMIOL, V19, P808, DOI 10.1016/j.annepidem.2009.04.005
Pinto-Martin JA, 2008, J DEV BEHAV PEDIATR, V29, P345, DOI 10.1097/DBP.0b013e31818914cf
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stahmer AC, 2007, ADM POLICY MENT HLTH, V34, P29, DOI 10.1007/s10488-006-0060-4
Stone WL, 2004, J AUTISM DEV DISORD, V34, P691, DOI 10.1007/s10803-004-5289-8
Stone WL, 2008, AUTISM, V12, P557, DOI 10.1177/1362361308096403
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
Warren Z, 2009, J DEV BEHAV PEDIATR, V30, P442, DOI 10.1097/DBP.0b013e3181ba0e4e
Warren ZE, 2011, PEDIATRICS, V127, P1303
Warren ZE, 2011, AUTISM SPECTRUM DISO, P1271
Zwaigenbaum L, 2006, SOCIAL COMMUNICATION, P88
NR 29
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 555
EP 561
DI 10.1177/1362361313481507
PG 7
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700010
PM 23847130
ER
PT J
AU Anderson, KA
Shattuck, PT
Cooper, BP
Roux, AM
Wagner, M
AF Anderson, Kristy A.
Shattuck, Paul T.
Cooper, Benjamin P.
Roux, Anne M.
Wagner, Mary
TI Prevalence and correlates of postsecondary residential status among
young adults with an autism spectrum disorder
SO AUTISM
LA English
DT Article
DE adult; autism; residence; transition
ID EMERGING ADULTHOOD; UNITED-STATES; TRANSITION; CHILDREN; HOME;
POPULATION; PATTERNS; SCHOOL; YOUTH; LIFE
AB This study examined the prevalence and correlates of three living arrangements (with a parent or guardian, independently or with a roommate, or in a supervised setting) among a nationally representative sample of postsecondary young adults with an autism spectrum disorder. We assessed living arrangements since leaving high school. Compared with young adults with other disability types (learning disabilities, intellectual disabilities, or emotional disturbances), those with an autism spectrum disorder were more likely to have lived with a parent or guardian and least likely ever to have lived independently since leaving high school. Members of the autism spectrum disorder group were less likely to have ever lived elsewhere and more likely to live under supervision since leaving high school compared to persons with emotional disturbances and learning disabilities. Group differences persisted after controlling for functional ability and demographic characteristics. Correlates of residential independence included being White, having better conversation ability and functional skills, and having a higher household income. Further research is needed to investigate how these residential trends relate to the quality of life among families and young adults.
C1 [Anderson, Kristy A.] Univ Wisconsin, Madison, WI 53705 USA.
[Anderson, Kristy A.; Shattuck, Paul T.; Cooper, Benjamin P.; Roux, Anne M.] Washington Univ, St Louis, MO USA.
[Wagner, Mary] SRI Int, Menlo Pk, CA USA.
RP Anderson, KA (reprint author), Univ Wisconsin, IDDRC Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM kaanderson8@wisc.edu
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
AQUILINO WS, 1990, J MARRIAGE FAM, V52, P405, DOI 10.2307/353035
Arnett JJ, 2000, AM PSYCHOL, V55, P469, DOI 10.1037//0003-066X.55.5.469
Aud S., 2011, AM YOUTH TRANSITIONS
Autism and Developmental Disabilities Monitoring Network (ADDM), 2012, MMWR SURVEILL SUMM, V61, P1
Berry B, 2006, J FAM ISSUES, V27, P1583, DOI 10.1177/0192513X06291498
Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
Centers for Disease Control and Prevention (CDC), 2012, COMM REP AUT DEV DIS
Cote J, 2008, J YOUTH STUD, V11, P251, DOI 10.1080/13676260801946464
De Marco AC, 2008, FAM SOC, V89, P208, DOI 10.1606/1044-3894.3736
Donovan M. S., 2002, MINORITY STUDENTS SP
Furstenberg FF, 2010, FUTURE CHILD, V20, P67
HALPERN AS, 1993, EXCEPT CHILDREN, V59, P486
Hendricks DR, 2009, FOCUS AUTISM DEV DIS, V24, P77, DOI 10.1177/1088357608329827
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Interagency Autism Coordinating Committee (IACC), 2011, IACC STRAT PLAN AUT
Kins E, 2009, DEV PSYCHOL, V45, P1416, DOI 10.1037/a0015580
Leiter V, 2009, MARRIAGE FAM REV, V45, P519
Levy SE, 2010, J DEV BEHAV PEDIATR, V31, P267, DOI 10.1097/DBP.0b013e3181d5d03b
Myktyta L, 2012, SHARING HOUSEHOLD HO
Newman L, 2011, POST HIGH SCH OUTCOM
Osgood W, 2010, FUTURE CHILD, V20, P209, DOI DOI 10.7208/CHICAG0/9780226637853.001.0001
Osgood W., 2005, YOUR OWN NET TRANSIT
Raghunathan T, 2001, SURV METHODOL, V27, P85
Ruble L, 1996, FOCUS AUTISM OTHER D, V11, P1088
Sassler S, 2008, SOCIOL FORUM, V23, P670, DOI 10.1111/j.1573-7861.2008.00090.x
Shanahan MJ, 2000, ANNU REV SOCIOL, V26, P667, DOI 10.1146/annurev.soc.26.1.667
Shattuck PT, 2012, CAN J PSYCHIAT, V57, P284
Shattuck PT, 2011, PLOS ONE, V6, P141
Shattuck PT, 2012, ARCH PEDIAT ADOL MED, V165, P141
Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
Smith T, 2004, AGEING INT, V29, P136, DOI 10.1007/s12126-004-1014-3
SRI International, 2000, NAT LONG TRANS STUD
Wagner M., 1993, TRANSITION EXPERIENC
Wagner M, 2005, J EMOT BEHAV DISORD, V13, P25, DOI 10.1177/10634266050130010301
Wells T, 2003, SOC FORCES, V82, P803, DOI 10.1353/sof.2004.0029
Williamson R. L., 2010, J VOCATIONAL REHABIL, V33, P101
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 40
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 562
EP 570
DI 10.1177/1362361313481860
PG 9
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700011
PM 23996904
ER
PT J
AU Frazier, TW
Youngstrom, EA
Embacher, R
Hardan, AY
Constantino, JN
Law, P
Findling, RL
Eng, C
AF Frazier, Thomas W.
Youngstrom, Eric A.
Embacher, Rebecca
Hardan, Antonio Y.
Constantino, John N.
Law, Paul
Findling, Robert L.
Eng, Charis
TI Demographic and clinical correlates of autism symptom domains and autism
spectrum diagnosis
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; autism symptoms; diagnosis; prediction
ID SOCIAL RESPONSIVENESS SCALE; GENERAL-POPULATION; CHILDREN; TRAITS;
DISORDERS; VALIDATION; VALIDITY; CRITERIA; TWIN; AGE
AB Demographic and clinical factors may influence assessment of autism symptoms. This study evaluated these correlates and also examined whether social communication and interaction and restricted/repetitive behavior provided unique prediction of autism spectrum disorder diagnosis. We analyzed data from 7352 siblings included in the Interactive Autism Network registry. Social communication and interaction and restricted/repetitive behavior symptoms were obtained using caregiver-reports on the Social Responsiveness Scale. Demographic and clinical correlates were covariates in regression models predicting social communication and interaction and restricted/repetitive behavior symptoms. Logistic regression and receiver operating characteristic curve analyses evaluated the incremental validity of social communication and interaction and restricted/repetitive behavior domains over and above global autism symptoms. Autism spectrum disorder diagnosis was the strongest correlate of caregiver-reported social communication and interaction and restricted/repetitive behavior symptoms. The presence of comorbid diagnoses also increased symptom levels. Social communication and interaction and restricted/repetitive behavior symptoms provided significant, but modest, incremental validity in predicting diagnosis beyond global autism symptoms. These findings suggest that autism spectrum disorder diagnosis is by far the largest determinant of quantitatively measured autism symptoms. Externalizing (attention deficit hyperactivity disorder) and internalizing (anxiety) behavior, low cognitive ability, and demographic factors may confound caregiver-report of autism symptoms, potentially necessitating a continuous norming approach to the revision of symptom measures. Social communication and interaction and restricted/repetitive behavior symptoms may provide incremental validity in the diagnosis of autism spectrum disorder.
C1 [Frazier, Thomas W.; Embacher, Rebecca; Eng, Charis] Cleveland Clin, Cleveland, OH 44104 USA.
[Youngstrom, Eric A.] Univ N Carolina, Chapel Hill, NC USA.
[Hardan, Antonio Y.] Stanford Univ, Stanford, CA 94305 USA.
[Constantino, John N.] Washington Univ, St Louis, MO USA.
[Law, Paul] Kennedy Krieger Inst, Baltimore, MD 21205 USA.
[Findling, Robert L.] Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
RP Frazier, TW (reprint author), Cleveland Clin, Ctr Autism CRS10, 2801 Martin Luther King Jr Dr, Cleveland, OH 44104 USA.
EM fraziet2@ccf.org
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2011, DSM 5 DEV 299 00 AUT
Bryk A. S., 1992, HIERARCHICAL LINEAR
Carter AS, 2007, J AUTISM DEV DISORD, V37, P86, DOI 10.1007/s10803-006-0331-7
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
Cohen J, 1987, STAT POWER ANAL BEHA
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Constantino JN, 2005, SOCIAL RESPONSIVENES
Frazier TW, 2008, J AUTISM DEV DISORD, V38, P474, DOI 10.1007/s10803-007-0415-z
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
Kalb LG, 2010, J AUTISM DEV DISORD, V40, P1389, DOI 10.1007/s10803-010-0998-7
KREFT IGG, 1995, J EDUC BEHAV STAT, V20, P109, DOI 10.3102/10769986020002109
Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
LORD C, 1982, J AUTISM DEV DISORD, V12, P317, DOI 10.1007/BF01538320
Lord C., 2002, AUTISM DIAGNOSTIC OB
Lundstrom S, 2011, PSYCHOL MED, V41, P2423, DOI 10.1017/S0033291711000377
Mandy W, 2012, J AUTISM DEV DISORD, V42, P1304, DOI 10.1007/s10803-011-1356-0
Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
Mayes SD, 2010, RES AUTISM SPECT DIS, V5, P749
Mayes SD, 2009, J AUTISM DEV DISORD, V39, P1682, DOI 10.1007/s10803-009-0812-6
Mildenberger K, 2001, EUR CHILD ADOLES PSY, V10, P248
Moss J, 2008, J AUTISM DEV DISORD, V38, P1081, DOI 10.1007/s10803-007-0487-9
Peugh JL, 2005, EDUC PSYCHOL MEAS, V65, P717, DOI DOI 10.1177/0013164405278558
Piven J, 1997, AM J PSYCHIAT, V154, P185
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
Snow AV, 2009, J CHILD PSYCHOL PSYC, V50, P734, DOI 10.1111/j.1469-7610.2008.02018.x
Szatmari P, 2002, J AM ACAD CHILD PSY, V41, P467, DOI 10.1097/00004583-200204000-00020
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
NR 36
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 571
EP 582
DI 10.1177/1362361313481506
PG 12
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700012
PM 24104512
ER
PT J
AU Bekele, E
Crittendon, JA
Swanson, A
Sarkar, N
Warren, ZE
AF Bekele, Esubalew
Crittendon, Julie A.
Swanson, Amy
Sarkar, Nilanjan
Warren, Zachary E.
TI Pilot clinical application of an adaptive robotic system for young
children with autism
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; joint attention; robotics; technology
ID SPECTRUM DISORDERS; JOINT ATTENTION; MOBILE ROBOT; INTERVENTIONS;
IMITATION
AB It has been argued that clinical applications of advanced technology may hold promise for addressing impairments associated with autism spectrum disorders. This pilot feasibility study evaluated the application of a novel adaptive robot-mediated system capable of both administering and automatically adjusting joint attention prompts to a small group of preschool children with autism spectrum disorders (n = 6) and a control group (n = 6). Children in both groups spent more time looking at the humanoid robot and were able to achieve a high level of accuracy across trials. However, across groups, children required higher levels of prompting to successfully orient within robot-administered trials. The results highlight both the potential benefits of closed-loop adaptive robotic systems as well as current limitations of existing humanoid-robotic platforms.
C1 [Bekele, Esubalew; Crittendon, Julie A.; Swanson, Amy; Sarkar, Nilanjan; Warren, Zachary E.] Vanderbilt Univ, Nashville, TN 37203 USA.
RP Warren, ZE (reprint author), Vanderbilt Univ, Vanderbilt Kennedy Ctr, Treatment & Res Inst Autism Spectrum Disorders TR, PMB 74,230 Appleton Pl, Nashville, TN 37203 USA.
EM zachary.e.warren@vanderbilt.edu
CR Annaz D, 2012, J AUTISM DEV DISORD, V42, P401, DOI 10.1007/s10803-011-1256-3
(APA) APA, 2000, DIAGN STAT MAN MENT
Bekele E, 2011, P 20 IEEE INT S ROB, P276
Bellani M, 2011, EPIDEMIOL PSYCH SCI, V20, P235, DOI 10.1017/S2045796011000448
Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019
Constantino J. N., 2009, SOCIAL RESPONSIVENES
Dautenhahn K, 2003, ROBOTICA, V21, P443, DOI 10.1017/S0263574703004922
Dautenhahn K, 2004, PRAGMAT COGN, V12, P1, DOI DOI 10.1075/PC.12.1.03DAU
Dautenhahn K, 2002, MU S ART SOC SIM ORG, V3, P117
Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
Duquette A, 2008, AUTON ROBOT, V24, P147, DOI 10.1007/s10514-007-9056-5
Feil-Seifer D., 2011, Proceedings of the 2011 6th ACM/IEEE International Conference on Human-Robot Interaction (HRI 2011), DOI 10.1145/1957656.1957785
Francois Michaud and Catherine Theberge-Turmel, 2002, SOCIALLY INTELLIGENT, P125
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Goodwin MS, 2008, FOCUS AUTISM DEV DIS, V23, P125, DOI 10.1177/1088357608316678
Gotham K, 2007, J AUTISM DEV DISORD, V37, P400, DOI DOI 10.1007/S10803-006-0280-1
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Kozima H., 2005, ROB HUM INT COMM 200, P341, DOI 10.1109/ROMAN.2005.1513802
Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
Liu CC, 2008, IEEE T ROBOT, V24, P883, DOI 10.1109/TRO.2008.2001362
Lord C, 2000, J AUTISM DEV DISORD, V30, P2055
Mullen E, 1995, MULLEN SCALES EARLY
Mundy P, 2001, INT REV RES MENT RET, V23, P139
Peacock G, 2012, J DEV BEHAV PEDIATR, V33, P2, DOI 10.1097/DBP.0b013e31823969de
Pierno AC, 2008, NEUROPSYCHOLOGIA, V46, P448, DOI 10.1016/j.neuropsychologia.2007.08.020
Poon KK, 2012, J AUTISM DEV DISORD, V42, P1064, DOI 10.1007/s10803-011-1349-z
Robins B, 2009, ADV COMPUTER HUMAN I, P205
Robins B, 2004, P CAMBR WORKSH UN AC, P225
Robins B, 2004, INTERACT STUD, V5, P161, DOI 10.1075/is.5.2.02rob
Robins B, 2006, INTERACT STUD, V7, P479
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Rutter M., 2003, SOCIAL COMMUNICATION
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
Yoder PJ, 2006, SOCIAL COMMUNICATION, P88
NR 39
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JUL
PY 2014
VL 18
IS 5
BP 598
EP 608
DI 10.1177/1362361313479454
PG 11
WC Psychology, Developmental
SC Psychology
GA AJ3JP
UT WOS:000337562700014
PM 24104517
ER
PT J
AU Latta, A
Rampton, T
Rosemann, J
Peterson, M
Mandleco, B
Dyches, T
Roper, S
AF Latta, A.
Rampton, T.
Rosemann, J.
Peterson, M.
Mandleco, B.
Dyches, T.
Roper, S.
TI Snapshots reflecting the lives of siblings of children with autism
spectrum disorders
SO CHILD CARE HEALTH AND DEVELOPMENT
LA English
DT Article
DE autism spectrum disorder; qualitative; siblings
ID BEHAVIORAL-ADJUSTMENT; PHOTO-ELICITATION; DEVELOPMENTAL-DISABILITIES;
COPING STRATEGIES; INDIVIDUALS; PHOTOGRAPHY; PERCEPTIONS; STRESS; LIFE;
EXPERIENCES
AB Background Past research focused on the effects of raising a child with autism spectrum disorder on families. However, most research examined parents' perspectives rather than siblings' perspectives. Therefore, the purpose of this qualitative descriptive design was to use photo elicitation to capture perspectives of siblings living with a child with autism spectrum disorder. Methods Fourteen siblings (nine male) of 13 children with autism spectrum disorder received disposable cameras with 24-27 colour exposures, and were asked to photograph what was important to them within 2 weeks. After developing snapshots, investigators interviewed siblings about their photographs, and used open, axial and selective coding to determine photograph categories and subcategories. Results Two major categories were found: people (family members, non-family members) and non-people (personal items/objects, animals, buildings, scenery). Interviews about photographs reflected experiences siblings had with people/non-people in the snapshots and their normal everyday activities. Most photographs revealed family life and activities any sibling would experience whether or not they lived in a family raising a child with autism spectrum disorder. Conclusions Photo elicitation facilitates communication between children and health-care professionals, and provides information about living with a child with autism spectrum disorder from the sibling's perspective. This information contributes to our knowledge base and allows development of specific intervention plans for siblings of these children.
C1 [Latta, A.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Rampton, T.] Alaska Hlth Fairs, Anchorage, AK USA.
[Rosemann, J.] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA.
[Peterson, M.] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
[Mandleco, B.] Brigham Young Univ, Coll Nursing, Provo, UT 84602 USA.
[Dyches, T.] Brigham Young Univ, Dept Counseling Psychol & Special Educ, Provo, UT 84602 USA.
[Roper, S.] Brigham Young Univ, Coll Family Home & Social Sci, Provo, UT 84602 USA.
RP Mandleco, B (reprint author), Brigham Young Univ, Coll Nursing, 474 SWKT, Provo, UT 84602 USA.
EM barbara-mandleco@byu.edu
FU College of Nursing, at Brigham Young University, Provo, UT; Family
Studies Center, at Brigham Young University, Provo, UT
FX This project was funded by the College of Nursing, and the Family
Studies Center, at Brigham Young University, Provo, UT.
CR AITKEN SC, 1993, PROF GEOGR, V45, P65, DOI 10.1111/j.0033-0124.1993.00065.x
Banister E., 2006, QUALITATIVE MARKET R, V8, P157
Barak-Levy Y, 2010, J FAM STUD, V16, P155
Benderix Ylva, 2007, J Pediatr Nurs, V22, P410, DOI 10.1016/j.pedn.2007.08.013
Berman H, 2001, Can J Nurs Res, V32, P21
Boucher J., 2006, BRIT J DEV DISABIL, V52, P19
Brody GH, 1998, ANNU REV PSYCHOL, V49, P1, DOI 10.1146/annurev.psych.49.1.1
Bruce BS, 2009, INT J INJ CONTROL SA, V16, P189, DOI 10.1080/17457300903306914
Cappello M., 2005, FIELD METHOD, V17, P170, DOI DOI 10.1177/1525822X05274553
Cicirelli V. G., 1995, SIBLING RELATIONSHIP
Clark-Ibanez M, 2004, AM BEHAV SCI, V47, P1507, DOI 10.1177/0002764204266236
Cox A., 2003, J FAMILY NURSING, V9, P397, DOI 10.1177/1074840703258328
Croghan R, 2008, INT J SOC RES METHOD, V11, P345, DOI 10.1080/13645570701605707
Denzin N. K., 2000, HDB QUALITATIVE RES
Dickie J, 2011, LITERACY, V45, P25, DOI 10.1111/j.1741-4369.2011.00574.x
Docherty S, 1999, RES NURS HEALTH, V22, P177, DOI 10.1002/(SICI)1098-240X(199904)22:2<177::AID-NUR9>3.0.CO;2-H
Drew SE, 2010, QUAL HEALTH RES, V20, P1677, DOI 10.1177/1049732310377455
Dyches T. T., 2013, HUMAN EXCEPTIONALITY, P266
Dyches TT, 2004, RES PRACT PERS SEV D, V29, P172, DOI 10.2511/rpsd.29.3.172
Einarsdottir J., 2005, EARLY CHILD DEV CARE, V175, P523, DOI DOI 10.1080/03004430500131320
Epstein T, 2008, CHILD CARE HLTH DEV, V34, P503, DOI 10.1111/j.1365-2214.2008.00834.x
Ferraioli S. J., 2010, SOCIAL WORK MENTAL H, V8, P41
Gamliel I, 2009, J AUTISM DEV DISORD, V39, P1131, DOI 10.1007/s10803-009-0727-2
Glover-Graf N. M., 2000, REHABILITATION ED, V14, P285
Guerrero AL, 2010, ANTHROPOL EDUC QUART, V41, P55, DOI 10.1111/j.1548-1492.2010.01067.x
Hanna K M, 1993, Issues Compr Pediatr Nurs, V16, P155, DOI 10.3109/01460869309078272
Hanna K M, 1995, J Pediatr Nurs, V10, P321, DOI 10.1016/S0882-5963(05)80050-8
Hastings RP, 2003, J AUTISM DEV DISORD, V33, P99, DOI 10.1023/A:1022290723442
Hastings RP, 2007, J AUTISM DEV DISORD, V37, P1485, DOI 10.1007/s10803-006-0230-y
Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
Hwang SK, 2010, DISABIL SOC, V25, P579, DOI 10.1080/09687599.2010.489305
Isenberg J. P., 2003, MAJOR TRENDS ISSUSES
Kaminsky L, 2001, J AUTISM DEV DISORD, V31, P399, DOI 10.1023/A:1010664603039
Kaminsky L, 2002, J CHILD PSYCHOL PSYC, V43, P225, DOI 10.1111/1469-7610.00015
Lassetter JH, 2007, QUAL HEALTH RES, V17, P456, DOI 10.1177/1049732306298804
Lorenz LS, 2009, HEALTH EXPECT, V12, P262, DOI 10.1111/j.1369-7625.2009.00560.x
Macks RJ, 2007, J AUTISM DEV DISORD, V37, P1060, DOI 10.1007/s10803-006-0249-0
Mavropoulou S., 2007, 8 INT C AUT EUR OSL
Melson GF, 2003, AM BEHAV SCI, V47, P31, DOI 10.1177/0002764203255210
Meyer KA, 2011, RES AUTISM SPECT DIS, V5, P1413, DOI 10.1016/j.rasd.2011.01.027
Moss G., 2001, J RES READ, V24, P279, DOI 10.1111/1467-9817.00149
National Institute of Mental Health (NIMH), 2013, WHAT ARE AUT SPECTR
Hema DA, 2009, CHILD CARE HLTH DEV, V35, P330, DOI 10.1111/j.1365-2214.2009.00937.x
Newman M., 2006, CHILDRENS GEOGRAPHIE, V4, P289, DOI 10.1080/14733280601005617
O' Brien Irene, 2009, Br J Nurs, V18, P1360
Opperman S, 2003, DISABIL REHABIL, V25, P441, DOI 10.1080/0963828031000069735
Orsmond GI, 2007, MENT RETARD DEV D R, V13, P313, DOI 10.1002/mrdd.20171
Orsmond GI, 2009, AUTISM, V13, P59, DOI 10.1177/1362361308097119
Pelchat Diane, 2007, J Child Health Care, V11, P112, DOI 10.1177/1367493507076064
Petalas MA, 2009, AUTISM, V13, P471, DOI 10.1177/1362361309335721
Petalas MA, 2009, INT J DISABIL DEV ED, V56, P381, DOI 10.1080/10349120903306715
Pilowsky T, 2004, J CHILD PSYCHOL PSYC, V45, P855, DOI 10.1111/j.1469-7610.2004.00277.x
Polit D. F., 2010, ESSENTIALS NURSING R, V7th
Rampton TB, 2007, J FAM NURS, V13, P420, DOI 10.1177/1074840707308580
Rhea P., 2009, J AUTISM DEV DISORD, V39, P115
Riley RG, 2004, J ADV NURS, V48, P397, DOI 10.1111/j.1365-2648.2004.03208.x
Rivers JW, 2003, J AUTISM DEV DISORD, V33, P383, DOI 10.1023/A:1025006727395
Ross P, 2006, J INTELLECT DEV DIS, V31, P77, DOI 10.1080/13668250600710864
Sage KD, 2010, J INTELLECT DEV DIS, V35, P92, DOI 10.3109/13668251003712788
Samuels J, 2004, AM BEHAV SCI, V47, P1528, DOI 10.1177/0002764204266238
Smith Laura O, 2010, J Child Adolesc Psychiatr Nurs, V23, P189, DOI 10.1111/j.1744-6171.2010.00240.x
Percy M S, 1995, Holist Nurs Pract, V9, P24
Sontag S., 1977, PHOTOGRAPHY
Spence LJ, 2002, WESTERN J NURS RES, V24, P639, DOI 10.1177/019394502236637
Stone WL, 2007, ARCH PEDIAT ADOL MED, V161, P384, DOI 10.1001/archpedi.161.4.384
Thupayagale-Tshweneagae Gloria, 2011, Issues Ment Health Nurs, V32, P355, DOI 10.3109/01612840.2011.576128
Tiegerman-Farber E., 2009, LANG COMMUN, P314
Verte S, 2003, CHILD CARE HLTH DEV, V29, P193, DOI 10.1046/j.1365-2214.2003.00331.x
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
White A, 2010, QUAL RES, V10, P143, DOI 10.1177/1468794109356735
NR 70
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1862
EI 1365-2214
J9 CHILD CARE HLTH DEV
JI Child Care Health Dev.
PD JUL
PY 2014
VL 40
IS 4
BP 515
EP 524
DI 10.1111/cch.12100
PG 10
WC Psychology, Developmental; Pediatrics
SC Psychology; Pediatrics
GA AJ3EC
UT WOS:000337547500008
PM 23952538
ER
PT J
AU Huber, S
Fieder, M
AF Huber, Susanne
Fieder, Martin
TI Advanced paternal age is associated with lower facial attractiveness
SO EVOLUTION AND HUMAN BEHAVIOR
LA English
DT Article
DE Paternal age; Education; Early life; Attractiveness; Wisconsin
Longitudinal Study
ID DE-NOVO MUTATIONS; PHYSICAL ATTRACTIVENESS; EVOLUTIONARY PSYCHOLOGY;
RISK; SCHIZOPHRENIA; POPULATION; DEPRESSION; AUTISM; COHORT
AB In view of disease risk, Kong et al. (2012) demonstrated that most of the new mutations are explained by the age of the father at conception. Accordingly, paternal age effects have been found for a variety of offspring traits, from physical and mental health to intelligence. Here, we investigated whether facial attractiveness is significantly associated with paternal age. We used the Wisconsin Longitudinal Study (n = 4018 male and 4416 female high school graduates) to analyze the association between an individual's father's age at birth and that individual's facial attractiveness (estimated by rating the high school yearbook photographs from 1957), controlling for sex, age as well as mother's age. We find that subject's facial attractiveness decreased with advancing paternal but not maternal age, suggesting that facial attractiveness might be a cue of an individual's new mutation load. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Huber, Susanne; Fieder, Martin] Univ Vienna, Dept Anthropol, A-1090 Vienna, Austria.
RP Huber, S (reprint author), Univ Vienna, Dept Anthropol, Althanstr 14, A-1090 Vienna, Austria.
EM susanne.huber@univie.ac.at
FU National Institute of Aging [AG-9775, AG-21079, AG-033285]; Vilas Estate
Trust; National Science Foundation; Spencer Foundation; Graduate School
of the University of Wisconsin-Madison
FX We thank Geoffrey Miller and the other anonymous reviewers for their
constructive and helpful comments and suggestions. This research uses
data from the Wisconsin Longitudinal Study (WLS) of the University of
Wisconsin-Madison. Since 1991, the WLS has been supported principally by
the National Institute of Aging (AG-9775 AG-21079 and AG-033285), with
additional support from the Vilas Estate Trust, the National Science
Foundation, the Spencer Foundation, and the Graduate School of the
University of Wisconsin-Madison. A public use file of data from the
Wisconsin Longitudinal Study is available from the Wisconsin
Longitudinal Study, University of Wisconsin-Madison, 1180 Observatory
Drive, Madison, Wisconsin 53706 and at
http://www.ssc.wisc.edu/wlsresearch/data/. The opinions expressed herein
are those of the authors.
CR Arden R, 2009, INTELLIGENCE, V37, P581, DOI 10.1016/j.intell.2009.03.008
Bray I, 2006, J EPIDEMIOL COMMUN H, V60, P851, DOI 10.1136/jech.2005.045179
Brown AS, 2002, AM J PSYCHIAT, V159, P1528, DOI 10.1176/appi.ajp.159.9.1528
Cannon M, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000042
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Crow JF, 2000, NAT REV GENET, V1, P40, DOI 10.1038/35049558
Eriksen W, 2013, AM J HUM BIOL, V25, P29, DOI 10.1002/ajhb.22333
Fink B, 2002, CURR DIR PSYCHOL SCI, V11, P154, DOI 10.1111/1467-8721.00190
Frans EM, 2008, ARCH GEN PSYCHIAT, V65, P1034, DOI 10.1001/archpsyc.65.9.1034
Granados JAT, 2009, P NATL ACAD SCI USA, V106, P17290, DOI 10.1073/pnas.0904491106
Haselton MG, 2006, HUM NATURE-INT BIOS, V17, P50, DOI 10.1007/s12110-006-1020-0
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Hume DK, 2001, EVOL HUM BEHAV, V22, P93, DOI 10.1016/S1090-5138(00)00065-9
Jokela M, 2009, EVOL HUM BEHAV, V30, P342, DOI 10.1016/j.evolhumbehav.2009.03.006
Keller M. C., 2008, MATING INTELLIGENCE, P173
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Lee A. J., 2013, PSYCHOL SCI
Liu F, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002932
Malaspina D, 2001, SCHIZOPHRENIA BULL, V27, P379
McGovern RJ, 1996, J PSYCHOL, V130, P209
Miller G, 2000, ANN NY ACAD SCI, V907, P62
Mitchem D. G., 2013, BEHAV GENETICS
Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
Rhodes G, 2006, ANNU REV PSYCHOL, V57, P199, DOI 10.1146/annurev.psych.57.102904.190208
ROWE DC, 1987, BEHAV GENET, V17, P191, DOI 10.1007/BF01065997
Saha S, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000040
Sefcek J. A., 2007, J PSYCHOL HUMAN SEXU, V18, P125, DOI 10.1300/J056v18n02_05
Sipos A, 2004, BRIT MED J, V329, P1070, DOI 10.1136/bmj.38243.672396.55
Thornhill R, 1999, TRENDS COGN SCI, V3, P452, DOI 10.1016/S1364-6613(99)01403-5
Vestergaard M, 2005, EUR J EPIDEMIOL, V20, P1003, DOI 10.1007/s10654-005-4250-2
Weeden J, 2005, PSYCHOL BULL, V131, P635, DOI 10.1037/0033-2909.131.5.635
NR 31
TC 3
Z9 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1090-5138
EI 1879-0607
J9 EVOL HUM BEHAV
JI Evol. Hum. Behav.
PD JUL
PY 2014
VL 35
IS 4
BP 298
EP 301
DI 10.1016/j.evolhumbehav.2014.02.011
PG 4
WC Psychology, Biological; Behavioral Sciences; Social Sciences, Biomedical
SC Psychology; Behavioral Sciences; Biomedical Social Sciences
GA AJ5IB
UT WOS:000337714800007
ER
PT J
AU Gizzonio, V
Avanzini, P
Fabbri-Destro, M
Campi, C
Rizzolatti, G
AF Gizzonio, Valentina
Avanzini, Pietro
Fabbri-Destro, Maddalena
Campi, Cristina
Rizzolatti, Giacomo
TI Cognitive abilities in siblings of children with autism spectrum
disorders
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Siblings; Cognitive profile; Endophenotype; WISC
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS; SOCIAL
RESPONSIVENESS SCALE; SCHIZOPHRENIC CHILDREN; 1ST-DEGREE RELATIVES;
ASPERGER-SYNDROME; FOLLOW-UP; PATTERNS; PROFILES; INDIVIDUALS
AB The aim of the present study was to assess the cognitive profiles of children with autistic spectrum disorder and of their healthy siblings (Siblings). With the term cognitive profile, we indicate the relationship extant among the values of verbal and performance subtests of the Wechsler Intelligence Scale. The conducted statistical analyses indicated that, although siblings showed a normal intelligent quotient and did not differ in this aspect from typically developing group, their cognitive profile was amazingly similar to that of their relatives affected by autism. A k-means clustering analysis on the values of single subtests further confirmed this result, showing a clear separation between typically developing children on the one side, and autistics and their siblings on the other. We suggest that the common cognitive profile observed in autistic children and their siblings could represent a marker of liability to autism and, thus, a possible intermediate phenotype of this syndrome.
C1 [Gizzonio, Valentina; Avanzini, Pietro; Campi, Cristina; Rizzolatti, Giacomo] Univ Parma, Dipartimento Neurosci, Sez Fisiol, I-43100 Parma, Italy.
[Fabbri-Destro, Maddalena; Rizzolatti, Giacomo] Italian Inst Technol, Brain Ctr Social & Motor Cognit, I-43100 Parma, Italy.
RP Rizzolatti, G (reprint author), Univ Parma, Dipartimento Neurosci, Sez Fisiol, Via Volturno 39-E, I-43100 Parma, Italy.
EM giacomo.rizzolatti@unipr.it
FU ERC [250013]
FX VG, PA and CC were supported by ERC Grant Cogsystem to GR, contract no.
250013. We thank Dr. Fabio Sambataro and Sonia Boria for critical
reading and for their remarks on previous versions of the manuscript. A
special thanks to the staff of the Pediatric Neuropsychiatry of Empoli,
of the rehabilitation center for autism "Centro Mai Soli" in Genova, of
the Institute of Rehabilitation "Village Eugenio Litta," Grottaferrata,
Roma, and of the Autism Center of Parma for their invaluable
collaboration in data collection. We also thank the staff and families
of IV Circolo "Risorgimento - San Berardo" primary school in Teramo for
providing the control group. Last but not least, thanks to all the
children and their families for the availability and patience.
CR ALLEN MH, 1991, J AUTISM DEV DISORD, V21, P483, DOI 10.1007/BF02206872
Almasy L, 2001, AM J MED GENET, V105, P42, DOI 10.1002/1096-8628(20010108)105:1<42::AID-AJMG1055>3.0.CO;2-9
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Anderberg MR, 1973, CLUSTER ANAL APPL
Ankenman K, 2014, AJIDD-AM J INTELLECT, V119, P84, DOI 10.1352/1944-7558-119.1.84
ASARNOW RF, 1987, J CHILD PSYCHOL PSYC, V28, P273, DOI 10.1111/j.1469-7610.1987.tb00210.x
AUGUST GJ, 1981, BRIT J PSYCHIAT, V138, P416, DOI 10.1192/bjp.138.5.416
Buitelaar JK, 1999, DEV PSYCHOPATHOL, V11, P39, DOI 10.1017/S0954579499001947
Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075
Constantino JN, 2013, J CHILD PSYCHOL PSYC, V54, P695, DOI 10.1111/jcpp.12064
Constantino JN, 2005, SOCIAL RESPONSIVENES
Delorme R, 2007, EUR PSYCHIAT, V22, P32, DOI 10.1016/j.eurpsy.2006.05.002
Dennis M, 1999, J AUTISM DEV DISORD, V29, P5, DOI 10.1023/A:1025962431132
Ehlers S, 1997, J CHILD PSYCHOL PSYC, V38, P207, DOI 10.1111/j.1469-7610.1997.tb01855.x
Folstein SE, 1999, J CHILD PSYCHOL PSYC, V40, P1117, DOI 10.1017/S0021963099004461
Fombonne E, 1997, J CHILD PSYCHOL PSYC, V38, P667, DOI 10.1111/j.1469-7610.1997.tb01694.x
FREEMAN BJ, 1985, J AM ACAD CHILD PSY, V24, P459, DOI 10.1016/S0002-7138(09)60565-3
FREEMAN BJ, 1989, AM J PSYCHIAT, V146, P361
Girardot AM, 2012, ENCEPHALE, V38, P488, DOI 10.1016/j.encep.2012.01.013
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P1461, DOI 10.1111/j.1469-7610.1994.tb01287.x
Hughes C, 1999, J CHILD PSYCHOL PSYC, V40, P705, DOI 10.1017/S0021963099004023
Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P698, DOI 10.1111/jcpp.12065
Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
Kaland N, 2007, AUTISM, V11, P81, DOI 10.1177/1362361307070988
Kawakubo Y, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006881
Kendler KS, 2010, MOL PSYCHIATR, V15, P789, DOI 10.1038/mp.2010.8
LEBOYER M, 1995, DEV NEUROPSYCHOL, V11, P139
LINCOLN AJ, 1988, J AUTISM DEV DISORD, V18, P505, DOI 10.1007/BF02211870
LOCKYER L, 1970, BRIT J SOC CLIN PSYC, V9, P152
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
MINTON J, 1982, J AM ACAD CHILD PSY, V21, P256, DOI 10.1016/S0002-7138(09)60880-3
Narita T, 1987, ADV BIOL PSYCHIAT, V16, P156
Neves Maila de Castro Lourenço das, 2011, Rev. Bras. Psiquiatr., V33, P261, DOI 10.1590/S1516-44462011000300009
Oerlemans AM, 2014, EUR CHILD ADOLES PSY, V23, P257, DOI 10.1007/s00787-013-0446-2
OHTA M, 1987, J AUTISM DEV DISORD, V17, P45, DOI 10.1007/BF01487259
Orsini L, 2006, WESCHSLER INTELLIGEN
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
OZONOFF S, 1993, J AUTISM DEV DISORD, V23, P429, DOI 10.1007/BF01046049
Pilowsky T, 2007, J AUTISM DEV DISORD, V37, P537, DOI 10.1007/s10803-006-0185-z
Piven J, 1997, AM J PSYCHIAT, V154, P185
Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748
SCHNEIDER SG, 1987, J ABNORM CHILD PSYCH, V15, P29, DOI 10.1007/BF00916464
SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
Siegel DJ, 1996, J AUTISM DEV DISORD, V26, P389, DOI 10.1007/BF02172825
SZATMARI P, 1993, J AM ACAD CHILD PSY, V32, P1264, DOI 10.1097/00004583-199311000-00022
SZATMARI P, 1990, J AM ACAD CHILD PSY, V29, P130, DOI 10.1097/00004583-199001000-00021
Waldman ID, 2005, BIOL PSYCHIAT, V57, P1347, DOI 10.1016/j.biopsych.2005.03.002
Wechsler D., 1974, MANUAL WECHSLER INTE
Wechsler D., 2003, WISC 4 TECHNICAL INT
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
NR 56
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
EI 1432-1106
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD JUL
PY 2014
VL 232
IS 7
BP 2381
EP 2390
DI 10.1007/s00221-014-3935-8
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AJ6GK
UT WOS:000337788600031
PM 24710667
ER
PT J
AU Hunsaker, MR
Scott, JA
Bauman, MD
Schumann, CM
Amaral, DG
AF Hunsaker, Michael R.
Scott, Julia A.
Bauman, Melissa D.
Schumann, Cynthia M.
Amaral, David G.
TI Postnatal development of the hippocampus in the Rhesus macaque (Macaca
mulatta): A longitudinal magnetic resonance imaging study
SO HIPPOCAMPUS
LA English
DT Article
DE Rhesus macaque; magnetic resonance imaging; hippocampus; longitudinal
development; primate model
ID NEONATAL AMYGDALA LESIONS; BRAIN-DEVELOPMENT; QUANTITATIVE-ANALYSIS;
DENTATE GYRUS; TEMPORAL-LOBE; GENDER-DIFFERENCES; NONHUMAN PRIMATE;
MONKEYS; CHILDREN; AUTISM
AB Nonhuman primates are widely used models to investigate the neural substrates of human behavior, including the development of higher cognitive and affective function. Due to their neuroanatomical and behavioral homologies with humans, the rhesus macaque monkey (Macaca mulatta) provides an excellent animal model in which to characterize the maturation of brain structures from birth through adulthood and into senescence. To evaluate hippocampal development in rhesus macaques, structural magnetic resonance imaging scans were obtained longitudinally at 9 time points between 1 week and 260 weeks (5 years) of age on 24 rhesus macaque monkeys (12 males, 12 females). In our sample, the hippocampus reaches 50% of its adult volume by 13 weeks of age and reaches an adult volume by 52 weeks in both males and females. The hippocampus appears to be slightly larger at 3 years than at 5 years of age. Male rhesus macaques have larger hippocampi than females from 8 weeks onward by approximately 5%. Interestingly, there was increased variability in hemispheric asymmetry for hippocampus volumes at younger ages than at later ages. These data provide a comprehensive evaluation of the longitudinal development of male and female rhesus macaque hippocampus across development from 1 week to 5 years of age. (c) 2014 Wiley Periodicals, Inc.
C1 [Hunsaker, Michael R.; Scott, Julia A.; Bauman, Melissa D.; Schumann, Cynthia M.; Amaral, David G.] Univ Calif Davis, Dept Psychiat & Behav Sci, Med Ctr, Sacramento, CA 95817 USA.
[Hunsaker, Michael R.; Bauman, Melissa D.; Schumann, Cynthia M.; Amaral, David G.] Univ Calif Davis, Med Ctr, MIND Inst, Sacramento, CA 95817 USA.
[Scott, Julia A.] Univ Calif Davis, Program Neurosci, MIND Inst, Sacramento, CA 95817 USA.
[Bauman, Melissa D.; Amaral, David G.] Univ Calif Davis, Calif Natl Primate Res Ctr, MIND Inst, Sacramento, CA 95817 USA.
RP Amaral, DG (reprint author), Univ Calif Davis, Dept Psychiat & Behav Sci, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM dgamaral@ucdavis.edu
FU NIH [R01 NS016980, R37 MH57502]
FX Grant sponsor: NIH; Grant number: R01 NS016980 and R37 MH57502.
CR Alvarado MC, 2005, HIPPOCAMPUS, V15, P118, DOI 10.1002/hipo.20037
Bauman MD, 2006, BEHAV NEUROSCI, V120, P749, DOI 10.1037/0735-7044.120.4.749
Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x
Avants BB, 2010, NEUROIMAGE, V49, P2457, DOI 10.1016/j.neuroimage.2009.09.062
Avants BB, 2011, NEUROIMAGE, V54, P2033, DOI 10.1016/j.neuroimage.2010.09.025
Bachevalier J, 1999, BIOL PSYCHIAT, V46, P329, DOI 10.1016/S0006-3223(99)00123-7
Bachevalier J, 2006, BEHAV NEUROSCI, V120, P989, DOI 10.1037/0735-7044.120.4.989
Bachevalier J, 1999, BEHAV NEUROSCI, V113, P1127, DOI 10.1037/0735-7044.113.6.1127
BAUMAN M, 1985, NEUROLOGY, V35, P866
Bauman MD, 2004, J COGNITIVE NEUROSCI, V16, P1388, DOI 10.1162/0898929042304741
Bauman MD, 2008, BEHAV NEUROSCI, V122, P1005, DOI 10.1037/a0012600
Bauman MD, 2004, J NEUROSCI, V24, P711, DOI 10.1523/JNEUROSCI.3263-03.2004
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Casey BJ, 2000, BIOL PSYCHOL, V54, P241, DOI 10.1016/S0301-0511(00)00058-2
Caviness VS, 1999, BRAIN DEV-JPN, V21, P289
Caviness VS, 1996, CEREB CORTEX, V6, P726, DOI 10.1093/cercor/6.5.726
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2000, RADIOLOGY, V216, P672
Csernansky JG, 1998, P NATL ACAD SCI USA, V95, P11406, DOI 10.1073/pnas.95.19.11406
DeBoer T, 2007, BEHAV BRAIN FUNCT, V3, DOI 10.1186/1744-9081-3-54
Dierssen M, 1996, DEV BRAIN RES, V95, P122, DOI 10.1016/0165-3806(96)00071-5
ECKENHOFF MF, 1991, DEV BRAIN RES, V64, P129, DOI 10.1016/0165-3806(91)90216-6
ECKENHOFF MF, 1988, J NEUROSCI, V8, P2729
FILIPEK PA, 1994, CEREB CORTEX, V4, P344, DOI 10.1093/cercor/4.4.344
Franklin MS, 2000, BRAIN RES, V852, P263, DOI 10.1016/S0006-8993(99)02093-4
Giedd JN, 2010, NEUROPSYCHOL REV, V20, P349, DOI 10.1007/s11065-010-9151-9
Giedd JN, 1996, J COMP NEUROL, V366, P223, DOI 10.1002/(SICI)1096-9861(19960304)366:2<223::AID-CNE3>3.0.CO;2-7
Giedd Jay N, 2008, Novartis Found Symp, V289, P101
Giedd JN, 1997, PROG NEURO-PSYCHOPH, V21, P1185, DOI 10.1016/S0278-5846(97)00158-9
Giedd JN, 2009, J AM ACAD CHILD PSY, V48, P465, DOI 10.1097/CHI.0b013e31819f2715
Giedd JN, 2012, BIOL SEX DIFFER, V3, DOI 10.1186/2042-6410-3-19
Harrison PJ, 1999, BRAIN, V122, P593, DOI 10.1093/brain/122.4.593
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
Huppi PS, 1998, ANN NEUROL, V43, P224, DOI 10.1002/ana.410430213
Huppi PS, 2006, SEMIN FETAL NEONAT M, V11, P489, DOI 10.1016/j.siny.2006.07.006
Jabes A, 2011, J COMP NEUROL, V519, P1051, DOI 10.1002/cne.22549
Jabes A, 2010, EUR J NEUROSCI, V31, P273, DOI 10.1111/j.1460-9568.2009.07061.x
Jack CR, 2000, NEUROLOGY, V55, P484
Jenkinson M, 2012, NEUROIMAGE, V62, P782, DOI 10.1016/j.neuroimage.2011.09.015
Kalin Ned H, 2004, Psychopharmacol Bull, V38 Suppl 1, P8
KALIN NH, 1989, SCIENCE, V243, P1718, DOI 10.1126/science.2564702
Keuker JIH, 2003, NEUROBIOL AGING, V24, P157, DOI 10.1016/S0197-4580(02)00062-3
Knickmeyer RC, 2008, J NEUROSCI, V28, P12176, DOI 10.1523/JNEUROSCI.3479-08.2008
Lavenex P, 2011, HIPPOCAMPUS, V21, P142, DOI 10.1002/hipo.20730
Lavenex P, 2007, DEV NEUROSCI-BASEL, V29, P179, DOI 10.1159/000096222
Lavenex PB, 2006, J NEUROSCI, V26, P4546, DOI 10.1523/JNEUROSCI.5412-05.2006
Lenroot RK, 2008, DEV PSYCHOPATHOL, V20, P1161, DOI 10.1017/S0954579408000552
Leverenz JB, 1998, EXP NEUROL, V150, P296, DOI 10.1006/exnr.1997.6777
Lipska BK, 2002, NEUROTOX RES, V4, P469, DOI 10.1080/1029842021000022089
Machado CJ, 2003, J CHILD PSYCHOL PSYC, V44, P64, DOI 10.1111/1469-7610.00103
Malkova L, 2006, EUR J NEUROSCI, V24, P3204, DOI 10.1111/j.1460-9568.2006.05175.x
Payne C, 2010, HIPPOCAMPUS, V20, P922, DOI 10.1002/hipo.20688
Pfluger T, 1999, EPILEPSIA, V40, P414, DOI 10.1111/j.1528-1157.1999.tb00735.x
Rawlins R. G., 1986, CAYO SANTIAGO MACAQU
RAWLINS RG, 1984, J MED PRIMATOL, V13, P247
Raymond GV, 1996, ACTA NEUROPATHOL, V91, P117
Saitoh O, 2001, BRAIN, V124, P1317, DOI 10.1093/brain/124.7.1317
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
Schumann CM, 2007, HIPPOCAMPUS, V17, P486, DOI 10.1002/hipo.20282
Seress L, 1992, Epilepsy Res Suppl, V7, P3
Shamy JLT, 2006, NEUROBIOL AGING, V27, P1405, DOI 10.1016/j.neurobiolaging.2005.07.019
Sowell ER, 2004, NEUROSCIENTIST, V10, P372, DOI 10.1177/1073858404263960
Sowell ER, 2004, J NEUROSCI, V24, P8223, DOI 10.1523/JNEUROSCI.1798-04.2004
Tanaka C, 2012, DEV NEUROSCI-BASEL, V34, P477, DOI 10.1159/000345152
Thompson DK, 2009, HIPPOCAMPUS, V19, P118, DOI 10.1002/hipo.20492
Tustison NJ, 2010, IEEE T MED IMAGING, V29, P1310, DOI 10.1109/TMI.2010.2046908
UECKER A, 1993, BRAIN COGNITION, V22, P42, DOI 10.1006/brcg.1993.1023
Utsunomiya H, 1999, AM J NEURORADIOL, V20, P717
Wallace GL, 2006, J CHILD PSYCHOL PSYC, V47, P987, DOI 10.1111/j.1469-7610.2006.01676.x
Yushkevich PA, 2006, NEUROIMAGE, V31, P1116, DOI 10.1016/j.neuroimage.2006.01.015
NR 70
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1050-9631
EI 1098-1063
J9 HIPPOCAMPUS
JI Hippocampus
PD JUL
PY 2014
VL 24
IS 7
BP 794
EP 807
DI 10.1002/hipo.22271
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA AJ4TD
UT WOS:000337668200008
PM 24648155
ER
PT J
AU Tan, RJ
Wang, YD
Kleinstein, SE
Liu, YZ
Zhu, XL
Guo, HZ
Jiang, QH
Allen, AS
Zhu, MF
AF Tan, Renjie
Wang, Yadong
Kleinstein, Sarah E.
Liu, Yongzhuang
Zhu, Xiaolin
Guo, Hongzhe
Jiang, Qinghua
Allen, Andrew S.
Zhu, Mingfu
TI An Evaluation of Copy Number Variation Detection Tools from Whole-Exome
Sequencing Data
SO HUMAN MUTATION
LA English
DT Article
DE copy number variation; whole-exome sequencing; whole-genome sequencing;
evaluation studies
ID STRUCTURAL VARIATION; HUMAN GENOME; COMPUTATIONAL METHODS;
POPULATION-SCALE; DISCOVERY; AUTISM; SPECTRUM; DISEASE; POLYMORPHISM;
ALGORITHM
AB Copy number variation (CNV) has been found to play an important role in human disease. Next-generation sequencing technology, including whole-genome sequencing (WGS) and whole-exome sequencing (WES), has become a primary strategy for studying the genetic basis of human disease. Several CNV calling tools have recently been developed on the basis of WES data. However, the comparative performance of these tools using real data remains unclear. An objective evaluation study of these tools in practical research situations would be beneficial. Here, we evaluated four well-known WES-based CNV detection tools (XHMM, CoNIFER, ExomeDepth, and CONTRA) using real data generated in house. After evaluation using six metrics, we found that the sensitive and accurate detection of CNVs in WES data remains challenging despite the many algorithms available. Each algorithm has its own strengths and weaknesses. None of the exome-based CNV calling methods performed well in all situations; in particular, compared with CNVs identified from high coverage WGS data from the same samples, all tools suffered from limited power. Our evaluation provides a comprehensive and objective comparison of several well-known detection tools designed for WES data, which will assist researchers in choosing the most suitable tools for their research needs.
C1 [Tan, Renjie; Wang, Yadong; Liu, Yongzhuang; Guo, Hongzhe; Jiang, Qinghua] Harbin Inst Technol, Sch Comp Sci & Technol, Ctr Biomed Informat, Harbin 150001, Heilongjiang, Peoples R China.
[Tan, Renjie; Kleinstein, Sarah E.; Liu, Yongzhuang; Zhu, Xiaolin; Guo, Hongzhe; Allen, Andrew S.; Zhu, Mingfu] Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC USA.
[Kleinstein, Sarah E.] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Durham, NC USA.
[Allen, Andrew S.] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA.
[Zhu, Mingfu] Tute Genom, Provo, UT USA.
RP Wang, YD (reprint author), Harbin Inst Technol, Sch Comp Sci & Technol, Ctr Biomed Informat, Harbin 150001, Heilongjiang, Peoples R China.
EM ydwang@hit.edu.cn; mingfu@tutegenomics.com
FU Natural Science Foundation of China [61102149, 61173085]; China
Scholarship Council
FX Contract grant sponsors: The Natural Science Foundation of China
(61102149 and 61173085); The China Scholarship Council.
CR Abyzov A, 2011, GENOME RES, V21, P974, DOI 10.1101/gr.114876.110
Alkan C, 2009, NAT GENET, V41, P1061, DOI 10.1038/ng.437
Alkan C, 2011, NAT REV GENET, V12, P363, DOI 10.1038/nrg2958
Bochukova EG, 2010, NATURE, V463, P666, DOI 10.1038/nature08689
Boeva V, 2012, BIOINFORMATICS, V28, P423, DOI 10.1093/bioinformatics/btr670
Boeva V, 2011, BIOINFORMATICS, V27, P268, DOI 10.1093/bioinformatics/btq635
Chen K, 2009, NAT METHODS, V6, P677, DOI [10.1038/nmeth.1363, 10.1038/NMETH.1363]
Coin LJM, 2012, BIOINFORMATICS, V28, pI370, DOI 10.1093/bioinformatics/bts379
Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
Deng XT, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-267
Fromer M, 2012, AM J HUM GENET, V91, P597, DOI 10.1016/j.ajhg.2012.08.005
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Guo Y, 2013, BIOMED RES INT, V2013, P7
Hach F, 2010, NAT METHODS, V7, P576, DOI 10.1038/nmeth0810-576
Handsaker RE, 2011, NAT GENET, V43, P269, DOI 10.1038/ng.768
Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
Hinrichs AS, 2006, NUCLEIC ACIDS RES, V34, pD590, DOI 10.1093/nar/gkj144
Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
Itsara A, 2010, GENOME RES, V20, P1469, DOI 10.1101/gr.107680.110
Klambauer G, 2012, NUCLEIC ACIDS RES, V40, DOI 10.1093/nar/gks003
Koboldt DC, 2012, GENOME RES, V22, P568, DOI 10.1101/gr.129684.111
Krumm N, 2012, GENOME RES, V22, P1525, DOI 10.1101/gr.138115.112
Krumm N, 2013, AM J HUM GENET, V93, P595, DOI 10.1016/j.ajhg.2013.07.024
Langmead B, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-3-r25
Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
Li J, 2012, BIOINFORMATICS, V28, P1307, DOI 10.1093/bioinformatics/bts146
Liu BA, 2013, ONCOTARGET, V4, P1868
Magi A, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r120
McCarroll SA, 2008, NAT GENET, V40, P1166, DOI 10.1038/ng.238
Medvedev P, 2009, NAT METHODS, V6, pS13, DOI [10.1038/nmeth.1374, 10.1038/NMETH.1374]
Mills RE, 2011, NATURE, V470, P59, DOI 10.1038/nature09708
Ng SB, 2009, NATURE, V461, P272, DOI 10.1038/nature08250
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Plagnol V, 2012, BIOINFORMATICS, V28, P2747, DOI 10.1093/bioinformatics/bts526
Poultney CS, 2013, AM J HUM GENET, V93, P607, DOI 10.1016/j.ajhg.2013.09.001
Ramachandran A, 2011, BIOINF BIOM WORKSH B
Rigaill GJ, 2012, BIOINFORMATICS, V28, P2357, DOI 10.1093/bioinformatics/bts448
Sathirapongsasuti JF, 2011, BIOINFORMATICS, V27, P2648, DOI 10.1093/bioinformatics/btr462
Sebat J, 2004, SCIENCE, V305, P525, DOI 10.1126/science.1098918
Shi YH, 2013, BIOINFORMATICS, V29, P1461, DOI 10.1093/bioinformatics/btt151
Stankiewicz P, 2010, ANNU REV MED, V61, P437, DOI 10.1146/annurev-med-100708-204735
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
Xi R, 2012, CURR PROTOC HUM GENE, DOI [10.1002/0471142905.hg0719s75, DOI 10.1002/0471142905.HG0719S75]
Zhu MF, 2012, AM J HUM GENET, V91, P408, DOI 10.1016/j.ajhg.2012.07.004
NR 46
TC 9
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1059-7794
EI 1098-1004
J9 HUM MUTAT
JI Hum. Mutat.
PD JUL
PY 2014
VL 35
IS 7
BP 899
EP 907
DI 10.1002/humu.22537
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ5EQ
UT WOS:000337705500016
PM 24599517
ER
PT J
AU El Khatib, AA
El Tekeya, MM
El Tantawi, MA
Omar, T
AF El Khatib, Amira A.
El Tekeya, Magda M.
El Tantawi, Maha A.
Omar, Tarek
TI Oral health status and behaviours of children with Autism Spectrum
Disorder: a case-control study
SO INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
LA English
DT Article
ID DENTAL PATIENTS; MANAGEMENT
AB Background. Autism Spectrum Disorder (ASD) is a lifelong neuro-developmental disorder characterized by abnormalities in social interactions and communication and by stereotyped, repetitive activities.
Purpose. Assess the oral health status and behaviours of children with ASD.
Methods. The study included 100 children with ASD and 100 healthy children from Alexandria, Egypt. Data were collected using a questionnaire and clinical examination. Questionnaire assessed socio-demographics, medical history, dental history, oral hygiene, dietary habits, and presence of self-injurious behaviours. Clinical examination assessed behaviour during examination, gingival condition, plaque accumulation, caries, and other oral conditions.
Results. Children with ASD had significantly poorer oral hygiene and gingival condition than healthy children (P < 0.001 for both). No significant differences were found in caries prevalence or experience in primary or permanent dentition. More children with ASD behaved 'negatively' or 'definitely negatively' (37% and 11%) than did healthy controls (11% and 2%) (P < 0.0001). Self-injurious behaviour and bruxism were more practised by children with ASD (32% of children with ASD and 2% of healthy children, P < 0.001). More children with ASD had difficulty in accessing dental care (P = 0.002).
Conclusions. The oral condition of children with ASD might increase the risk of developing dental diseases. Their behaviour and life factors may complicate provision of services and limit access to dental care. Therefore, individualized oral health education programmes should be implemented for those children.
C1 [El Khatib, Amira A.] Univ Alexandria, Fac Dent, Dept Pediat Dent, Alexandria 21121, Egypt.
[El Tekeya, Magda M.; El Tantawi, Maha A.] Univ Alexandria, Fac Dent, Dent Publ Hlth Dept, Alexandria 21121, Egypt.
[Omar, Tarek] Univ Alexandria, Fac Med, Dept Pediat, Alexandria 21121, Egypt.
RP El Khatib, AA (reprint author), Univ Alexandria, Fac Dent, Dept Pediat Dent, Meroza Compound Villa 11B, Alexandria 21121, Egypt.
EM amira.a.h@hotmail.com
RI El Tantawi, Maha/K-4336-2014
OI El Tantawi, Maha/0000-0003-4989-6584
CR Altun C, 2010, PEDIATR DENT, V32, P343
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Bassoukou IH, 2009, CLIN ORAL INVEST, V13, P23, DOI 10.1007/s00784-008-0209-5
Centers for Disease Control and Prevention, CDV FEAT CDC STUD AV
DeMattei R, 2007, J Dent Hyg, V81, P65
Dias GG, 2010, J AUTISM DEV DISORD, V40, P704, DOI 10.1007/s10803-009-0918-x
Dover CJ, 2007, ARCH DIS CHILD, V92, P540, DOI 10.1136/adc.2005.086280
Fahlvik-Planefeldt C, 2001, SWED DENT J, V25, P113
Frankl S. N, 1962, J DENT CHILD, V29, P150
Friedlander AH, 2006, J AM DENT ASSOC, V137, P1517
Ghadi BA, 2010, THESIS FACULTY DENTI
Hernandez P, 2011, J AM DENT ASSOC, V142, P281
Hulland S, 2000, Spec Care Dentist, V20, P131, DOI 10.1111/j.1754-4505.2000.tb01149.x
Jaber MA, 2010, J INVEST CLIN DENT, V1, P1
Karande Sunil, 2006, Indian J Med Sci, V60, P205
Kirakowski J, 1997, LIST FREQUENCY ASKED
Knight DJ, 1997, AM J ORTHOD DENTOFAC, V112, P194, DOI 10.1016/S0889-5406(97)70246-4
Loe H., 1967, J PERIODONTAL, V41, P41
Loo CY, 2008, J AM DENT ASSOC, V139, P1518
LOWE O, 1985, J DENT CHILD, V52, P29
Marshall J, 2008, PEDIATR DENT, V30, P400
Marshall J, 2010, PEDIATR DENT, V32, P69
Marshall J, 2007, PEDIATR DENT, V29, P369
Mendoza RL, 2010, AM J EC BUSINESS ADM, V2, P12
Murshid EZ, 2005, SAUDI DENT J, V17, P132
Murshid EZ, 2011, J AUTISM DEV DISORD, V41, P1629, DOI 10.1007/s10803-011-1188-y
Namal Necmi, 2007, J Indian Soc Pedod Prev Dent, V25, P97
Purohit Bharathi M, 2010, Spec Care Dentist, V30, P235, DOI 10.1111/j.1754-4505.2010.00160.x
Rada RE, 2010, J AM DENT ASSOC, V141, P947
Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
Schreck KA, 2000, J AUTISM DEV DISORD, V30, P127, DOI 10.1023/A:1005407622050
Silness J., 1964, ACTA ODONTOL SCAND, V22, P112
Waldman H Barry, 2008, J Calif Dent Assoc, V36, P662
Weddell JA, 2004, DENT CHILD ADOLESCEN, P460
WHO, 1997, OR HLTH SURV BAS MET
NR 35
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0960-7439
EI 1365-263X
J9 INT J PAEDIATR DENT
JI Int. J. Paediatr. Dent.
PD JUL
PY 2014
VL 24
IS 4
BP 314
EP 323
DI 10.1111/ipd.12067
PG 10
WC Dentistry, Oral Surgery & Medicine; Pediatrics
SC Dentistry, Oral Surgery & Medicine; Pediatrics
GA AJ5CR
UT WOS:000337699400008
PM 24750459
ER
PT J
AU Froehlich-Santino, W
Tobon, AL
Cleveland, S
Torres, A
Phillips, J
Cohen, B
Torigoe, T
Miller, J
Fedele, A
Collins, J
Smith, K
Lotspeich, L
Croen, LA
Ozonoff, S
Lajonchere, C
Grether, JK
O'Hara, R
Hallmayer, J
AF Froehlich-Santino, Wendy
Tobon, Amalia Londono
Cleveland, Sue
Torres, Andrea
Phillips, Jennifer
Cohen, Brianne
Torigoe, Tiffany
Miller, Janet
Fedele, Angie
Collins, Jack
Smith, Karen
Lotspeich, Linda
Croen, Lisa A.
Ozonoff, Sally
Lajonchere, Clara
Grether, Judith K.
O'Hara, Ruth
Hallmayer, Joachim
TI Prenatal and perinatal risk factors in a twin study of autism spectrum
disorders
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Autism; Prenatal; Perinatal; Pregnancy complications; Twins; Environment
ID TRAUMATIC BRAIN-INJURY; LOW-BIRTH-WEIGHT; SEX-DIFFERENCES; COMPREHENSIVE
METAANALYSIS; COGNITIVE RECOVERY; MATERNAL AGE; FETAL SEX; HYPOXIA;
PROGESTERONE; OUTCOMES
AB Introduction: Multiple studies associate prenatal and perinatal complications with increased risks for autism spectrum disorders (ASDs). The objectives of this study were to utilize a twin study design to 1) Investigate whether shared gestational and perinatal factors increase concordance for ASDs in twins, 2) Determine whether individual neonatal factors are associated with the presence of ASDs in twins, and 3) Explore whether associated factors may influence males and females differently.
Methods: Data from medical records and parent response questionnaires from 194 twin pairs, in which at least one twin had an ASD, were analyzed.
Results: Shared factors including parental age, prenatal use of medications, uterine bleeding, and prematurity did not increase concordance risks for ASDs in twins. Among the individual factors, respiratory distress demonstrated the strongest association with increased risk for ASDs in the group as a whole (OR 2.11, 95% CI 1.27-3.51). Furthermore, respiratory distress (OR 2.29, 95% CI 1.12-4.67) and other markers of hypoxia (OR 1.99, 95% CI 1.04-3.80) were associated with increased risks for ASDs in males, while jaundice was associated with an increased risk for ASDs in females (OR 2.94, 95% CI 1.28-6.74).
Conclusions: Perinatal factors associated with respiratory distress and other markers of hypoxia appear to increase risk for autism in a subgroup of twins. Future studies examining potential gender differences and additional prenatal, perinatal and postnatal environmental factors are required for elucidating the etiology of ASDs and suggesting new methods for treatment and prevention. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Froehlich-Santino, Wendy; Tobon, Amalia Londono; Cleveland, Sue; Torres, Andrea; Phillips, Jennifer; Lotspeich, Linda; O'Hara, Ruth; Hallmayer, Joachim] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA.
[Cohen, Brianne; Torigoe, Tiffany; Miller, Janet; Fedele, Angie; Lajonchere, Clara] Autism Speaks, Autism Genet Resource Exchange, Los Angeles, CA USA.
[Collins, Jack; Croen, Lisa A.] Kaiser Permanente No Calif, Div Res, Oakland, CA USA.
[Smith, Karen] Impact Assessment Inc, La Jolla, CA USA.
[Ozonoff, Sally] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
[Grether, Judith K.] Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA USA.
RP Froehlich-Santino, W (reprint author), Stanford Univ, 401 Quarry Rd, Stanford, CA 94305 USA.
EM wendyf@stanford.edu
FU National Institute of Mental Health, United States [R01MH067005]; Autism
Speaks, United States
FX a. Grant Sponsor: National Institute of Mental Health, United States;
Grant number: R01MH067005,b. Grant Sponsor: Autism Speaks, United
States; Grant number: N/A
CR Aibar L, 2012, J PERINAT MED, V40, P271, DOI 10.1515/jpm-2011-0137
Amin SB, 2011, J AUTISM DEV DISORD, V41, P1455, DOI 10.1007/s10803-010-1169-6
Boksa P, 2003, NEUROSCI BIOBEHAV R, V27, P91, DOI 10.1016/S0149-7634(03)00012-5
Burstyn I, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-2
Di Renzo GC, 2007, GENDER MED, V4, P19, DOI 10.1016/S1550-8579(07)80004-0
Donders J, 2002, NEUROPSYCHOLOGY, V16, P491, DOI 10.1037//0894-4105.16.4.491
Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Grether JK, 2009, AM J EPIDEMIOL, V170, P1118, DOI 10.1093/aje/kwp247
GUALTIERI T, 1985, BEHAV BRAIN SCI, V8, P427
Guinchat V, 2012, ACTA OBSTET GYN SCAN, V91, P287, DOI 10.1111/j.1600-0412.2011.01325.x
Haglund NGS, 2011, AUTISM, V15, P163, DOI 10.1177/1362361309353614
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hill CA, 2011, DEV NEUROSCI-BASEL, V33, P494, DOI 10.1159/000331651
Hill CA, 2011, INT J DEV NEUROSCI, V29, P381, DOI 10.1016/j.ijdevneu.2011.03.005
Hill CA, 2012, NEUROL RES INT, V2012, DOI DOI 10.1155/2012/867531
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Knight SR, 2012, J NEUROENDOCRINOL, V24, P1135, DOI 10.1111/j.1365-2826.2012.02319.x
Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
Lampi KM, 2012, J PEDIATR-US, V161, P830, DOI 10.1016/j.jpeds.2012.04.058
Lan WCJ, 2011, PEDIATR RES, V70, P15, DOI 10.1038/pr.2011.240
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P926, DOI DOI 10.1093/AJE/KWI123
Lauterbach MD, 2001, NEUROPSYCHOLOGY, V15, P411, DOI 10.1037//0894-4105.15.3.411
Liu K, 2010, DEMOGRAPHY, V47, P327
Lord C., 1999, AUTISM DIAGNOSTIC OB
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Maramara LA, 2014, J CHILD NEUROL
Mayoral SR, 2009, PEDIATR RES, V66, P248, DOI 10.1203/PDR.0b013e3181b1bc34
Newman TB, 2011, PEDIATRICS, V127, pE858, DOI 10.1542/peds.2010-3769A
Nishino H, 1998, NEUROSCI RES, V30, P303, DOI 10.1016/S0168-0102(98)00010-8
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Pinto-Martin JA, 2011, PEDIATRICS, V128, P883, DOI 10.1542/peds.2010-2846
Previc FH, 2007, MED HYPOTHESES, V68, P46, DOI 10.1016/j.mehy.2006.06.041
RAZ S, 1995, DEV PSYCHOL, V31, P958, DOI 10.1037//0012-1649.31.6.958
Raz S, 2010, J INT NEUROPSYCH SOC, V16, P169, DOI 10.1017/S1355617709991147
Reddy DS, 2002, J NEUROSCI, V22, P3795
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Sandin S, 2012, J AM ACAD CHILD PSY, V51, P477, DOI 10.1016/j.jaac.2012.02.018
Sayeed I, 2006, ANN EMERG MED, V47, P381, DOI 10.1016/j.annemergmed.2005.12.011
Schumacher M, 2007, ENDOCR REV, V28, P387, DOI 10.1210/er.2006-0050
Stein DG, 2008, BRAIN RES REV, V57, P386, DOI 10.1016/j.brainresrev.2007.06.012
Stevenson DK, 2000, ARCH DIS CHILD, V83, pF182, DOI 10.1136/fn.83.3.F182
Vatten LJ, 2004, EARLY HUM DEV, V76, P47, DOI 10.1016/j.earlhumdev.2003.10.006
Xiao GM, 2008, CRIT CARE, V12, DOI 10.1186/cc6887
Yaniv SS, 2011, ARCH GYNECOL OBSTET, V283, P755, DOI 10.1007/s00404-010-1459-4
NR 49
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL
PY 2014
VL 54
BP 100
EP 108
DI 10.1016/j.jpsychires.2014.03.019
PG 9
WC Psychiatry
SC Psychiatry
GA AJ4MA
UT WOS:000337649300013
PM 24726638
ER
PT J
AU Kuriakose, S
AF Kuriakose, Sarah
TI Concurrent Validity of the WISC-IV and DAS-II in Children With Autism
Spectrum Disorder
SO JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
LA English
DT Article
DE cognitive assessment; autism; DAS-II; WISC-IV; concurrent validity;
autism spectrum disorder
ID HIGH-FUNCTIONING AUTISM; EARLY INTERVENTION PROGRAMS; BEHAVIORAL
TREATMENT; INTELLIGENCE SCALES; PRESCHOOL-CHILDREN; PROFILES; LEVEL;
AGE; ADOLESCENTS; DIAGNOSIS
AB Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad range of cognitive abilities. Participants achieved significantly higher overall scores on the DAS-II and nearly half the sample achieved a higher classification label on the DAS-II. The difference between overall scores is suggested to be attributable to a relative weakness in processing speed, which is assessed on the WISC-IV but not the DAS-II. Autistic symptomatology was not associated with cognitive scores, while adaptive behavior was positively associated. Neither was associated with the magnitude of difference between overall scores. Choice of assessment should be considered carefully given the systematic differences in overall scores produced in this population.
C1 [Kuriakose, Sarah] NYU, New York, NY 10016 USA.
RP Kuriakose, S (reprint author), NYU, Ctr Child Study, Langone Med Ctr, One Pk Ave 7th Floor, New York, NY 10016 USA.
EM sarah.kuriakose@nyumc.org
CR Akshoomoff N, 2006, CHILD NEUROPSYCHOL, V12, P269, DOI 10.1080/09297040500473714
American Psychiatric Association, 2013, DIAGNOSTIC STAT MANU
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Barnhill G., 2000, FOCUS AUTISM OTHER D, V15, P146, DOI [10.1177/108835760001500303, DOI 10.1177/108835760001500303]
Barona A., 2000, J PYSCHOEDUCATIONAL, V18, P344, DOI [10.1177/073428290001800404, DOI 10.1177/073428290001800404]
Barona A., 2000, DROP, V18, P344, DOI [10.1177/073428290001800404, DOI 10.1177/073428290001800404]
Black DO, 2009, J AUTISM DEV DISORD, V39, P1613, DOI 10.1007/s10803-009-0795-3
Bolte S, 2009, J AUTISM DEV DISORD, V39, P678, DOI 10.1007/s10803-008-0667-2
Coolican J, 2008, J AUTISM DEV DISORD, V38, P190, DOI 10.1007/s10803-007-0368-2
Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
Deutsch CK, 2003, J AUTISM DEV DISORD, V33, P209, DOI 10.1023/A:1022903913547
Dumont R, 1996, PSYCHOL SCHOOLS, V33, P203, DOI 10.1002/(SICI)1520-6807(199607)33:3<203::AID-PITS3>3.0.CO;2-Q
Dumont R., 2009, ESSENTIALS DAS 2 ASS
Elliott C., 2007, DIFFERENTIAL ABILITY
Elliott C. D., 1990, DIFFERENTIAL ABILITY
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Fiorello C. A., 2002, LEARN INDIVID DIFFER, V13, P115, DOI [10.1016/S1041-6080(02)00075-4, DOI 10.1016/S1041-6080(02)00075-4]
Flanagan DP, 2004, ESSENTIALS WISC 4 AS
Floyd RG, 2008, PROF PSYCHOL-RES PR, V39, P414, DOI 10.1037/0735-7028.39.4.414
Gilliam JE, 2006, GILLIAM AUTISM RATIN
Gresham FM, 1998, J AUTISM DEV DISORD, V28, P5, DOI 10.1023/A:1026002717402
HARRIS SL, 1991, J AUTISM DEV DISORD, V21, P281, DOI 10.1007/BF02207325
Kamphaus R. W., 2009, ASSESSING CHILDHOOD, P91, DOI 10.1007/978-0-387-09528-8_4
Kanne SM, 2008, NEUROPSYCHOL REV, V18, P367, DOI 10.1007/s11065-008-9072-z
LORD C, 1989, J AUTISM DEV DISORD, V19, P483, DOI 10.1007/BF02212853
Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Magiati I, 2001, AUTISM, V5, P399, DOI 10.1177/1362361301005004005
Matson JL, 2007, RES DEV DISABIL, V28, P207, DOI 10.1016/j.ridd.2005.07.006
Mayes SD, 2003, AUTISM, V7, P65, DOI 10.1177/1362361303007001006
Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4
Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
Minshew NJ, 2005, J AUTISM DEV DISORD, V35, P45, DOI 10.1007/s10803-004-1030-x
Montgomery J. M., 2008, WISC 4 CLIN ASSESSME, P299
Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
Ozonoff S, 2005, J CLIN CHILD ADOLESC, V34, P523, DOI 10.1207/s15374424jccp3403_8
Perry A., 2002, J DEV DISABILITIES, V9, P61
Raiford S. E., 2005, 4 WISC4
Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
Siegel DJ, 1996, J AUTISM DEV DISORD, V26, P389, DOI 10.1007/BF02172825
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Wechsler D., 2003, WECHSLER INTELLIGENC
NR 43
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0734-2829
EI 1557-5144
J9 J PSYCHOEDUC ASSESS
JI J. Psychoeduc. Assess.
PD JUL
PY 2014
VL 32
IS 4
BP 283
EP 294
DI 10.1177/0734282913511051
PG 12
WC Psychology, Educational
SC Psychology
GA AJ3VV
UT WOS:000337596900001
ER
PT J
AU Ghaleiha, A
Ghyasvand, M
Mohammadi, MR
Farokhnia, M
Yadegari, N
Tabrizi, M
Hajiaghaee, R
Yekehtaz, H
Akhondzadeh, S
AF Ghaleiha, Ali
Ghyasvand, Mohammad
Mohammadi, Mohammad-Reza
Farokhnia, Mehdi
Yadegari, Noorollah
Tabrizi, Mina
Hajiaghaee, Reza
Yekehtaz, Habibeh
Akhondzadeh, Shahin
TI Galantamine efficacy and tolerability as an augmentative therapy in
autistic children: A randomized, double-blind, placebo-controlled trial
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE Acetylcholinesterase inhibitor; autism; cholinergic; galantamine;
irritability; nicotinic receptor; randomized controlled trial;
risperidone; social withdrawal
ID NICOTINIC ACETYLCHOLINE-RECEPTORS; ALLOSTERIC POTENTIATING LIGAND;
SPECTRUM DISORDERS; ABERRANT BEHAVIOR; RISPERIDONE; BRAIN;
ABNORMALITIES; ATTENTION; SYSTEMS; DYSFUNCTION
AB The role of cholinergic abnormalities in autism was recently evidenced and there is a growing interest in cholinergic modulation, emerging for targeting autistic symptoms. Galantamine is an acetylcholinesterase inhibitor and an allosteric potentiator of nicotinic receptors. This study aimed to evaluate the possible effects of galantamine as an augmentative therapy to risperidone, in autistic children. In this randomized, double-blind, placebo-controlled, parallel-group study, 40 outpatients aged 4-12 years whom had a diagnosis of autism (DSM IV-TR) and a score of 12 or higher on the Aberrant Behavior Checklist-Community (ABC-C) Irritability subscale were equally randomized to receive either galantamine (up to 24 mg/day) or placebo, in addition to risperidone (up to 2 mg/day), for 10 weeks. We rated participants by ABC-C and a side effects checklist, at baseline and at weeks 5 and 10. By the study endpoint, the galantamine-treated patients showed significantly greater improvement in the Irritability (P = 0.017) and Lethargy/Social Withdrawal (P = 0.005) subscales than the placebo group. The difference between the two groups in the frequency of side effects was not significant. In conclusion, galantamine augmentation was shown to be a relatively effective and safe augmentative strategy for alleviating some of the autism-related symptoms.
C1 [Ghaleiha, Ali] Hamadan Univ Med Sci, Res Ctr Behav Disorders & Substance Abuse, Hamadan, Iran.
[Ghyasvand, Mohammad; Mohammadi, Mohammad-Reza; Farokhnia, Mehdi; Yadegari, Noorollah; Yekehtaz, Habibeh; Akhondzadeh, Shahin] Univ Tehran Med Sci, Roozbeh Hosp, Psychiat Res Ctr, Tehran 13337, Iran.
[Tabrizi, Mina] Univ Tehran Med Sci, Dept Med Genet, Tehran 13337, Iran.
[Hajiaghaee, Reza] Inst Med Plants, Med Plants Res Ctr, Karaj, Iran.
RP Akhondzadeh, S (reprint author), Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, South Kargar St, Tehran 13337, Iran.
EM s.akhond@neda.net
FU Tehran University of Medical Sciences [13216]
FX This work was supported by Tehran University of Medical Sciences (grant
number 13216 to SA). The funding organization had no role in the design
and conduct of the study; nor in the collection, analysis and
interpretation of the data; nor in the preparation, review or approval
of the manuscript; nor in the decision to submit the paper for
publication.
CR Abreu-Villaca Y, 2011, BEHAV BRAIN RES, V221, P367, DOI 10.1016/j.bbr.2009.12.049
Ago Y, 2011, J PHARMACOL SCI, V116, P6, DOI 10.1254/jphs.11R01CR
Akhondzadeh S, 2010, PROG NEURO-PSYCHOPH, V34, P32, DOI 10.1016/j.pnpbp.2009.09.012
AMAN MG, 1985, AM J MENT DEF, V89, P485
American Psychiatric Association, 2000, DIAGN CRIT DSM 4 TR
Asadabadi M, 2013, PSYCHOPHARMACOLOGY, V225, P51, DOI 10.1007/s00213-012-2796-8
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Belluardo N, 2000, ADV RES NEURODEGENER, V8, P227
Bentley P, 2003, NEUROIMAGE, V20, P58, DOI 10.1016/S1053-8119(03)00302-1
Blaylock RL, 2009, CURR MED CHEM, V16, P157
Bruel-Jungerman E, 2011, BEHAV BRAIN RES, V221, P379, DOI 10.1016/j.bbr.2011.01.021
Chilian B, 2013, CLIN GENET, V8
Clementi F, 2000, EUR J PHARMACOL, V393, P3, DOI 10.1016/S0014-2999(00)00066-2
Craig D, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004746.pub2
Dajas-Bailador FA, 2003, MOL PHARMACOL, V64, P1217, DOI 10.1124/mol.64.5.1217
De Souza FM, 2011, SCI REP, V1
Deutsch SI, 2010, CLIN NEUROPHARMACOL, V33, P114, DOI 10.1097/WNF.0b013e3181d6f7ad
Friedman SD, 2003, NEUROLOGY, V60, P100
Ghaemi SN, 2009, J CLIN PSYCHOPHARM, V29, P291, DOI 10.1097/JCP.0b013e3181a497d7
Ghaleiha A, 2013, INT J NEUROPSYCHOPH, V16, P783, DOI 10.1017/S1461145712000880
Hasanzadeh E, 2012, CHILD PSYCHIAT HUM D, V43, P674, DOI 10.1007/s10578-012-0292-3
Hertzman M, 2003, INT J PSYCHIAT MED, V33, P395, DOI 10.2190/JE5Q-1NFT-FL40-7PMW
Kumar B, 2012, PHARMACOL REP, V64, P1291
Lam KSL, 2006, RES DEV DISABIL, V27, P254, DOI 10.1016/j.ridd.2005.03.003
Lee M, 2002, BRAIN, V125, P1483, DOI 10.1093/brain/awf160
Litvinenko I V, 2008, Neurosci Behav Physiol, V38, P937, DOI 10.1007/s11055-008-9077-3
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Loy C, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001747.pub3
Madaan V, 2006, EXPERT REV NEUROTHER, V6, P1375, DOI 10.1586/14737175.6.9.1375
Maelicke A, 2001, BIOL PSYCHIAT, V49, P279, DOI 10.1016/S0006-3223(00)01109-4
Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003
Mudo G, 2007, J NEURAL TRANSM, V114, P135, DOI 10.1007/s00702-006-0561-z
Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
Nicolson R, 2006, PSYCHIAT RES-NEUROIM, V148, P11, DOI 10.1016/j.pscychresns.2006.02.005
Nicolson R, 2006, J CHILD ADOL PSYCHOP, V16, P621, DOI 10.1089/cap.2006.16.621
Niederhofer H, 2002, BRIT MED J, V325, P1422
Noda Y, 2010, INT J NEUROPSYCHOPH, V13, P1343, DOI 10.1017/S1461145710000222
Ochoa ELM, 2006, HUM PSYCHOPHARM CLIN, V21, P127, DOI 10.1002/hup.751
Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058
Petersen AK, 2013, EUR J MED GENET, V56, P118, DOI 10.1016/j.ejmg.2012.11.003
Ray MA, 2005, NEUROBIOL DIS, V19, P366, DOI 10.1016/j.nbd.2005.01.017
Rezaei V, 2010, PROG NEURO-PSYCHOPH, V34, P1269, DOI 10.1016/j.pnpbp.2010.07.005
Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Santos MD, 2002, MOL PHARMACOL, V61, P1222, DOI 10.1124/mol.61.5.1222
Schilstrom B, 2007, NEUROPSYCHOPHARMACOL, V32, P43, DOI 10.1038/sj.npp.1301087
Schubert MH, 2006, BIOL PSYCHIAT, V60, P530, DOI 10.1016/j.biopsych.2006.04.006
Sharp BM, 2004, J PHARMACOL EXP THER, V309, P1116, DOI 10.1124/jpet.103.063586
Sokol DK, 2002, J CHILD NEUROL, V17, P245, DOI 10.1177/088307380201700401
Wang DY, 2007, NEUROPHARMACOLOGY, V52, P1179, DOI 10.1016/j.neuropharm.2006.12.007
Wiker C, 2008, INT J NEUROPSYCHOPH, V11, P845, DOI 10.1017/S1461145708008730
Wilens TE, 2000, J CHILD ADOL PSYCHOP, V10, P217, DOI 10.1089/10445460050167322
WOOLF NJ, 1991, PROG NEUROBIOL, V37, P475, DOI 10.1016/0301-0082(91)90006-M
Yasui DH, 2011, HUM MOL GENET, V20, P4311, DOI 10.1093/hmg/ddr357
NR 54
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD JUL
PY 2014
VL 28
IS 7
BP 677
EP 685
DI 10.1177/0269881113508830
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AJ3PX
UT WOS:000337580300008
ER
PT J
AU Feinstein, NW
AF Feinstein, Noah Weeth
TI Making sense of autism: Progressive engagement with science among
parents of young, recently diagnosed autistic children
SO PUBLIC UNDERSTANDING OF SCIENCE
LA English
DT Article
DE engagement mapping; lay expertise; public engagement; public
understanding of science; scientific literacy; sociology of health and
illness
ID PARTICIPATION; BEHAVIOR
AB This exploratory study examines the significance of science to parents whose children were recently diagnosed with an autism spectrum disorder. It asks: (1) In what manner did science emerge in parents' concerns and resources as they attempted to understand and advocate for their children? (2) Did some parents engage with science in a qualitatively deeper or more intense manner? Using longitudinal data from interviews and a novel data collection strategy called engagement mapping, it shows that parents asked questions and used resources that were strongly associated with science, but these were vastly outnumbered by "near-science" concerns and resources that mingled meanings from science and daily life. Several parents in the study wove together concerns and resources in an iterative pattern referred to here as progressive engagement with science.
C1 [Feinstein, Noah Weeth] Univ Wisconsin, Dept Curriculum & Instruct, Madison, WI 53706 USA.
[Feinstein, Noah Weeth] Univ Wisconsin, Dept Community & Environm Sociol, Madison, WI 53706 USA.
RP Feinstein, NW (reprint author), Univ Wisconsin, Dept Curriculum & Instruct, 225 North Mills St, Madison, WI 53706 USA.
EM nfeinstein@wisc.edu
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
Barbour RS, 2001, BMJ-BRIT MED J, V322, P1115, DOI 10.1136/bmj.322.7294.1115
Brown P, 2006, SCI TECHNOL HUM VAL, V31, P499, DOI 10.1177/0162243906289610
Carpini MXD, 2004, ANNU REV POLIT SCI, V7, P315, DOI 10.1146/annurev.polisci.7.121003.091630
Casiday R, 2006, VACCINE, V24, P177, DOI 10.1016/j.vaccine.2005.07.063
Clarke C, 2010, PUBLIC UNDERST SCI, V20, P609, DOI DOI 10.1177/0963662509359490
Epstein S., 1998, IMPURE SCI AIDS ACTI
Epstein S., 2008, HDB SCI TECHNOLOGY S, P499
Galison Peter, 1997, IMAGE LOGIC MAT CULT
Gieryn Thomas F., 1999, CULTURAL BOUNDARIES
Gorman M. E., 2010, TRADING ZONES INTERA
Gray D, 1998, AUTISM FAMILY PROBLE
Gray D E, 1995, Med Anthropol, V16, P99
Heinrichs N, 2005, PREV SCI, V6, P275, DOI 10.1007/s11121-005-0006-1
Irwin A, 2003, SCI SOCIAL THEORY PU
Jenkins EW, 1999, INT J SCI EDUC, V21, P703, DOI 10.1080/095006999290363
King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
Laslo E, 2011, JOURNALISM, V12, P847, DOI 10.1177/1464884911412709
Latour B., 1987, SCI ACTION FOLLOW SC
Layton D., 1993, INARTICULATE SCI PER
Maslach C, 2001, ANNU REV PSYCHOL, V52, P397, DOI 10.1146/annurev.psych.52.1.397
Michael M, 1996, MISUNDERSTANDING SCI, P107, DOI 10.1017/CBO9780511563737.006
Moscovici S, 2008, PSYCHOANALYSIS ITS I
National Science Board, 2008, SCI ENG IND 2008
Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
Snow AV, 2011, J AUTISM DEV DISORD, V41, P302, DOI 10.1007/s10803-010-1054-3
STAR SL, 1989, SOC STUD SCI, V19, P387, DOI 10.1177/030631289019003001
Strauss A., 2008, BASICS QUALITATIVE R
WEINBERG AM, 1972, MINERVA, V10, P209, DOI 10.1007/BF01682418
Wynne B., 1992, PUBLIC UNDERST SCI, V1, P281, DOI [DOI 10.1088/0963-6625/1/3/004, DOI 10.1017/CB09780511563737.002]
NR 30
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0963-6625
EI 1361-6609
J9 PUBLIC UNDERST SCI
JI Public Underst. Sci.
PD JUL
PY 2014
VL 23
IS 5
BP 592
EP 609
DI 10.1177/0963662512455296
PG 18
WC Communication; History & Philosophy Of Science
SC Communication; History & Philosophy of Science
GA AJ3PA
UT WOS:000337577800007
PM 25414924
ER
PT J
AU Sarasua, SM
Boccuto, L
Sharp, JL
Dwivedi, A
Chen, CF
Rollins, JD
Rogers, RC
Phelan, K
DuPont, BR
AF Sarasua, Sara M.
Boccuto, Luigi
Sharp, Julia L.
Dwivedi, Alka
Chen, Chin-Fu
Rollins, Jonathan D.
Rogers, R. Curtis
Phelan, Katy
DuPont, Barbara R.
TI Clinical and genomic evaluation of 201 patients with Phelan-McDermid
syndrome
SO HUMAN GENETICS
LA English
DT Article
ID 22Q13.3 DELETION SYNDROME; AUTISM SPECTRUM DISORDERS; INVERTED
DUPLICATION; TERMINAL DELETION; SHANK3; GENE; MUTATIONS; IDENTIFICATION;
BREAKPOINT; GROWTH
AB This study is the first to describe age-related changes in a large cohort of patients with Phelan-McDermid syndrome (PMS), also known as 22q13 deletion syndrome. Over a follow-up period of up to 12 years, physical examinations and structured interviews were conducted for 201 individuals diagnosed with PMS, 120 patients had a focused, high-resolution 22q12q13 array CGH, and 92 patients' deletions were assessed for parent-of-origin. 22q13 genomic anomalies include terminal deletions of 22q13 (89 %), terminal deletions and interstitial duplications (9 %), and interstitial deletions (2 %). Considering different age groups, in older patients, behavioral problems tended to subside, developmental abilities improved, and some features such as large or fleshy hands, full or puffy eyelids, hypotonia, lax ligaments, and hyperextensible joints were less frequent. However, the proportion reporting an autism spectrum disorder, seizures, and cellulitis, or presenting with lymphedema or abnormal reflexes increased with age. Some neurologic and dysmorphic features such as speech and developmental delay and macrocephaly correlated with deletion size. Deletion sizes in more recently diagnosed patients tend to be smaller than those diagnosed a decade earlier. Seventy-three percent of de novo deletions were of paternal origin. Seizures were reported three times more often among patients with a de novo deletion of the maternal rather than paternal chromosome 22. This analysis improves the understanding of the clinical presentation and natural history of PMS and can serve as a reference for the prevalence of clinical features in the syndrome.
C1 [Sarasua, Sara M.; Boccuto, Luigi; Dwivedi, Alka; Chen, Chin-Fu; Rollins, Jonathan D.; Rogers, R. Curtis; DuPont, Barbara R.] Greenwood Genet Ctr, Off Bioinformat & Epidemiol, Greenwood, SC 29646 USA.
[Sharp, Julia L.] Clemson Univ, Dept Math Sci, Clemson, SC 29634 USA.
[Phelan, Katy] Tulane Univ, Sch Med, Hayward Genet Ctr, New Orleans, LA 70112 USA.
[Phelan, Katy] Tulane Univ, Sch Med, Dept Pediat, New Orleans, LA 70112 USA.
RP Sarasua, SM (reprint author), Greenwood Genet Ctr, Off Bioinformat & Epidemiol, 101 Gregor Mendel Circle, Greenwood, SC 29646 USA.
EM ssarasua@ggc.org
FU Phelan-McDermid Syndrome Foundation; Genetics Endowment of South
Carolina; South Carolina Department of Disabilities and Special Needs
FX This work was supported, in part, by a fellowship to SMS from the
Phelan-McDermid Syndrome Foundation; the Genetics Endowment of South
Carolina; and the South Carolina Department of Disabilities and Special
Needs.
CR Aldinger KA, 2013, AM J MED GENET A, V161A, P131, DOI 10.1002/ajmg.a.35700
Anderlid BM, 2002, HUM GENET, V110, P439, DOI 10.1007/s00439-002-0713-7
Ballif BC, 2003, HUM MOL GENET, V12, P2153, DOI 10.1093/hmg/ddg231
Betancur C, 2009, TRENDS NEUROSCI, V32, P402, DOI 10.1016/j.tins.2009.04.003
Boccuto L, 2013, EUR J HUM GENET, V21, P310, DOI 10.1038/ejhg.2012.175
Bonaglia MC, 2010, MONOGR HUM GENET, V18, P137
Bonaglia MC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002173
Bonaglia MC, 2006, J MED GENET, V43, P822, DOI 10.1136/jmg.2005.038604
Bonaglia MC, 2001, AM J HUM GENET, V69, P261, DOI 10.1086/321293
Capurro MI, 2005, CANCER RES, V65, P6245, DOI 10.1158/0008-5472.CAN-04-4244
Chen CP, 2005, AM J MED GENET A, V139A, P146, DOI 10.1002/ajmg.a.30997
Delahaye A, 2009, EUR J MED GENET, V52, P328, DOI 10.1016/j.ejmg.2009.05.004
Denayer A, 2012, MOL SYNDROMOL, V3, P14, DOI DOI 10.1159/000339119
Dhar SU, 2010, AM J MED GENET A, V152A, P573, DOI 10.1002/ajmg.a.33253
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
Grabrucker AM, 2011, TRENDS CELL BIOL, V21, P594, DOI 10.1016/j.tcb.2011.07.003
Hannachi H, 2013, CYTOGENET GENOME RES, V140, P1, DOI 10.1159/000350785
Collins FS, 2004, NATURE, V431, P931, DOI 10.1038/nature03001
Jeffries AR, 2005, AM J MED GENET A, V137A, P139, DOI 10.1002/ajmg.a.30780
Kent WJ, 2002, GENOME RES, V12, P996, DOI 10.1101/gr.229102
Kuczmarski R. J., 2002, VITAL HLTH STAT, V11, P1
Lindquist SG, 2005, CLIN DYSMORPHOL, V14, P55, DOI 10.1097/00019605-200504000-00001
Luciani JJ, 2003, J MED GENET, V40, P690, DOI 10.1136/jmg.40.9.690
Luedi PP, 2007, GENOME RES, V17, P1723, DOI 10.1101/gr.6584707
Manning MA, 2004, PEDIATRICS, V114, P451, DOI 10.1542/peds.114.2.451
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Misceo D, 2011, AM J MED GENET A, V155A, P403, DOI 10.1002/ajmg.a.33798
Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
Morison IM, 2001, NUCLEIC ACIDS RES, V29, P275, DOI 10.1093/nar/29.1.275
Phelan K, 2012, MOL SYNDROMOL, V2-5, P186, DOI DOI 10.1159/000334260
Phelan MC, 2001, AM J MED GENET, V101, P91, DOI 10.1002/1096-8628(20010615)101:2<91::AID-AJMG1340>3.0.CO;2-C
Philippe A, 2008, PEDIATRICS, V122, pE376, DOI 10.1542/peds.2007-2584
Pilia G, 1996, NAT GENET, V12, P241, DOI 10.1038/ng0396-241
Rollins JD, 2011, GROWTH REFERENCES
Rollins JD, 2010, J PEDIATR-US, V156, P907, DOI 10.1016/j.jpeds.2010.01.009
Rollins JD, 2011, AM J MED GENET A, V155A, P2324, DOI 10.1002/ajmg.a.34158
Rowe LR, 2009, J MED GENET, V46, P694, DOI 10.1136/jmg.2008.065052
Sarasua SM, 2011, J MED GENET, V48, P761, DOI 10.1136/jmedgenet-2011-100225
Sarasua SM, 2013, GEN MED IN PRESS
SAS Institute, 2009, SAS, V9.2
Soorya L, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-18
Wang JC, 2008, AM J MED GENET A, V146A, P1173, DOI 10.1002/ajmg.a.32246
Wilson HL, 2008, EUR J HUM GENET, V16, P1301, DOI 10.1038/ejhg.2008.107
Wilson HL, 2003, J MED GENET, V40, P575, DOI 10.1136/jmg.40.8.575
World Health Organization, 2006, WHO CHILD GROWTH STA
NR 46
TC 3
Z9 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD JUL
PY 2014
VL 133
IS 7
BP 847
EP 859
DI 10.1007/s00439-014-1423-7
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA AI7QD
UT WOS:000337088600002
PM 24481935
ER
PT J
AU Martoccio, TL
Brophy-Herb, HE
Onaga, EE
AF Martoccio, Tiffany L.
Brophy-Herb, Holly E.
Onaga, Esther E.
TI Road to Readiness Pathways From Low-Income Children's Early Interactions
to School Readiness Skills
SO INFANTS & YOUNG CHILDREN
LA English
DT Article
DE joint attention; low-income; parent-child interaction; school readiness
ID EARLY LITERACY DEVELOPMENT; INFANT JOINT ATTENTION; EARLY HEAD-START;
INDIVIDUAL-DIFFERENCES; PRESCHOOL-CHILDREN; EMOTION REGULATION;
LANGUAGE; AUTISM; PREDICTORS; TODDLERS
AB This study utilized data from the Michigan component of the National Early Head Start Research and Evaluation study to examine toddlers' joint attention at 14 months (parent report measure of toddlers' initiating behaviors, e. g., extends arm to show you something he or she is holding, reaches out and gives you a toy he or she has been holding, and points at something interesting) as a mediator of the relations between early mother-child interactions (e. g., mother and child behaviors in response to one another's cues) and later school readiness skills in a low-income sample (N = 127 mother-child dyads). Understanding relations between early parent-child interactions, joint attention, and later school readiness skills is critical to identifying developmental paths of economically at-risk children. Results showed that toddlers' joint attention behaviors at 14 months partially mediated the path between mother-child interaction at 14 months and later school readiness, measured by children's emotion regulation, social-cognition, language development, and literacy and mathematics academic outcomes, at approximately 5 years of age. Results suggest the important roles of early mother-child interactions in low-income families and joint attention in promoting school readiness skills.
C1 [Martoccio, Tiffany L.; Brophy-Herb, Holly E.; Onaga, Esther E.] Michigan State Univ, E Lansing, MI 48824 USA.
RP Martoccio, TL (reprint author), Michigan State Univ, 552 W Circle Dr,7 Human Ecol Bldg, E Lansing, MI 48824 USA.
EM martocc1@msu.edu
CR Adamson L.B., 1991, ANN CHILD DEV, V8, P1
AKHTAR N, 1991, J CHILD LANG, V18, P41
Assel M. A., 2003, APPL DEV SCI, V7, P27, DOI DOI 10.1207/S1532480XADS0701_3
Baumwell L, 1997, INFANT BEHAV DEV, V20, P247, DOI 10.1016/S0163-6383(97)90026-6
Bayley N, 1993, BAYLEY SCALES INFANT
Bentler PM, 1996, ANNU REV PSYCHOL, V47, P563, DOI 10.1146/annurev.psych.47.1.563
Bocknek EL, 2009, INFANT MENT HEALTH J, V30, P452, DOI 10.1002/imhj.20224
Brophy-Herb H. E., 2013, J SOC SOCIAL WORK RE, V4, P2, DOI [10.5243/jsswr.2013.1, DOI 10.5243/JSSWR.2013.1]
Brophy-Herb HE, 2013, FAM RELAT, V62, P326, DOI 10.1111/fare.12001
Brophy-Herb HE, 2012, EARLY CHILD RES Q, V27, P352, DOI 10.1016/j.ecresq.2011.11.005
Buss A. H., 1984, TEMPERAMENT EARLY DE
Carpenter M., 2000, AUTISM SPECTRUM DISO, P31
Carpenter M., 1998, MONOGRAPHS SOC RES C, V63
Ceballo R, 2002, CHILD DEV, V73, P1310, DOI 10.1111/1467-8624.00473
Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830
Chase-Lansdale P. L., 1995, ESCAPE POVERTY WHAT
Chazan-Cohen R, 2007, INFANT MENT HEALTH J, V28, P151, DOI 10.1002/imhj.20127
Claussen AH, 2002, DEV PSYCHOPATHOL, V14, P279
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Davidov M, 2006, CHILD DEV, V77, P44, DOI 10.1111/j.1467-8624.2006.00855.x
DeTemple J. M., 2001, PARENTS CHILDREN REA
Dodici BJ, 2003, TOP EARLY CHILD SPEC, V23, P124, DOI 10.1177/02711214030230030301
Dunn L. M., 1981, PEABODY PICTURE VOCA
TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
Fenson L, 2000, APPL PSYCHOLINGUIST, V21, P95
Gauvain M, 2005, INT CULT PSYCHOL, P11, DOI 10.1007/0-387-27550-9_2
Gibson E., 1979, ATTENTION COGNITIVE, P103
Gross D, 2009, PREV SCI, V10, P54, DOI 10.1007/s11121-008-0116-7
Hustedt JT, 2002, INT J BEHAV DEV, V26, P113, DOI 10.1080/01650250042000636
Joreskog K. G., 1996, LISREL 8 USERS REFER
Kline R. B., 2005, PRINCIPLES PRACTICE, V2nd
Kochanska G, 1997, CHILD DEV, V68, P94, DOI 10.2307/1131928
Lee R, 2014, DEV PSYCHOL, V50, P202, DOI 10.1037/a0032280
Love JM, 2005, DEV PSYCHOL, V41, P885, DOI 10.1037/0012-1649.41.6.885
Markus J, 2000, SOC DEV, V9, P302, DOI 10.1111/1467-9507.00127
McDonald RP, 1996, MULTIVAR BEHAV RES, V31, P239, DOI 10.1207/s15327906mbr3102_5
McDonald RP, 2002, PSYCHOL METHODS, V7, P64, DOI 10.1037//1082-989X.7.1.64
McGroder SM, 2000, CHILD DEV, V71, P752, DOI 10.1111/1467-8624.00183
Morales M, 2005, INT J BEHAV DEV, V29, P259, DOI 10.1080/01650250444000432
Mundy P., 2006, DEV PSYCHOPATHOL, V1, P293
Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
Mundy P., 2003, MANUAL ABRIDGED EARL
Musil CM, 1998, RES NURS HEALTH, V21, P271
Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
Raver CC, 1996, EARLY DEV PARENTING, V5, P225
Rheingold H., 1976, CHILD DEV, V83, P898
Risley T. R., 1995, MEANINGFUL DIFFERENC
Rogoff B., 1984, NEW DIR CHILD ADOLES, V23, P31
Roid G., 1997, LEITER INT PERFORMAN
Rollins PR, 1998, J CHILD LANG, V25, P653
Rush KL, 1999, TOP EARLY CHILD SPEC, V19, P3, DOI 10.1177/027112149901900101
Schertz HH, 2007, J AUTISM DEV DISORD, V37, P1562, DOI 10.1007/s10803-006-0290-z
Schiffman R. F., 1996, PATHWAYS PROJE UNPUB
Shimpi P., 2007, J CHILD LANG, V34, P1
Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
Smith V, 2007, J SPEECH LANG HEAR R, V50, P149, DOI 10.1044/1092-4388(2007/013)
Striano T, 2007, INFANT BEHAV DEV, V30, P529, DOI 10.1016/j.infbeh.2006.12.010
Sumner G., 1994, NCAST CAREGIVER PARE
Tamis-LeMonda CS, 2001, CHILD DEV, V72, P748, DOI 10.1111/1467-8624.00313
Tomasello M, 1996, J CHILD LANG, V23, P157
Van Hecke AV, 2007, CHILD DEV, V78, P53
Vaughan A, 2003, INFANCY, V4, P603, DOI 10.1207/S15327078IN0404_11
Woodcock R. W., 2001, W JOHNSON 3 TESTS AC
NR 64
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0896-3746
EI 1550-5081
J9 INFANT YOUNG CHILD
JI Infants Young Child.
PD JUL-SEP
PY 2014
VL 27
IS 3
BP 193
EP 206
DI 10.1097/IYC.0000000000000014
PG 14
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AI9YF
UT WOS:000337303100001
ER
PT J
AU Vilaseca, R
Ferrer, F
Olmos, JG
AF Vilaseca, Rosa
Ferrer, Fina
Guardia Olmos, Joan
TI Gender differences in positive perceptions, anxiety, and depression
among mothers and fathers of children with intellectual disabilities: a
logistic regression analysis
SO QUALITY & QUANTITY
LA English
DT Article
DE Positive perceptions; Anxiety; Depression; Children with intellectual
disabilities; Families; Logistic regression
ID SCHOOL-AGED CHILDREN; MENTAL-HEALTH; DEVELOPMENTAL-DISABILITIES;
BEHAVIOR PROBLEMS; HOSPITAL ANXIETY; PARENTAL STRESS; EARLY
INTERVENTION; SOCIAL SUPPORT; AUTISM; POPULATION
AB This study explores gender differences in positive perceptions, anxiety, and depression among mothers and fathers of children with intellectual disabilities (IDs). We examined the relationship between these variables and certain characteristics of both the child (age and severity of disability) and the parents (age, educational level, and employment status). A sample of 60 mother/father couples who had children with IDs completed the Positive Contributions Scale to measure their positive perceptions, and the Hospital Anxiety and Depression Scale to assess their level of anxiety and depression. Bivariate analyses were used to determine differences between fathers and mothers as regards their positive perceptions and levels of anxiety and depression. A logistic regression model was then applied to identify which of the variables might be significant predictors of the gender differences observed among parents. Both mothers and fathers had positive perceptions of their children with IDs that co-existed with symptoms of anxiety and depression, with scores being higher among mothers. The predictive analysis of gender showed that individual variables (such as the employment status of both parents) may explain these differences.
C1 [Vilaseca, Rosa; Ferrer, Fina] Univ Barcelona, Dept Dev & Educ Psychol, Barcelona 08035, Spain.
[Guardia Olmos, Joan] Univ Barcelona, Dept Methodol Behav Sci, Inst Res Brain Cognit & Behav IR3C, Barcelona, Spain.
RP Vilaseca, R (reprint author), Univ Barcelona, Dept Dev & Educ Psychol, Pg Vall dHebron 171, Barcelona 08035, Spain.
EM rosavilaseca@ub.edu; fferrer@ub.edu; jguardia@ub.edu
CR Abele A. E., 2001, KLIN PSYCHOL FRAU, P559
Behr S., 1992, USERS MANUAL KANSAS
Blacher J., 2002, BEST AAMR FAMILIES M
Blackledge JT, 2006, CHILD FAM BEHAV THER, V28, P1, DOI 10.1300/J019v28n01_01
BYRNE EA, 1985, J CHILD PSYCHOL PSYC, V26, P847, DOI 10.1111/j.1469-7610.1985.tb00602.x
Caro I., 1992, B PSICOL, V36, P43
Dyson LL, 1997, AM J MENT RETARD, V102, P267, DOI 10.1352/0895-8017(1997)102<0267:FAMOSC>2.0.CO;2
DYSON LL, 1993, AM J MENT RETARD, V98, P207
Field A., 2009, DISCOVERING STAT USI
Folkman S, 2000, AM PSYCHOL, V55, P647, DOI 10.1037//0003-066X.55.6.647
Gine C., 2010, QUALITY LIFE PEOPLE
Gine C., 2013, J INTELLECT DEV DIS, V38, P1
Glidden L. M., 2006, J POLICY PRACT INTEL, V3, P139, DOI 10.1111/j.1741-1130.2006.00067.x
Glidden LM, 2009, J INTELL DISABIL RES, V53, P998, DOI 10.1111/j.1365-2788.2009.01217.x
Gray David E., 1992, Australia and New Zealand Journal of Developmental Disabilities, V18, P83
Guralnick M, 2001, INFANT YOUNG CHILD, V14, P1
Guralnick M. J., 2006, J POLICY PRACT INTEL, V3, P49, DOI DOI 10.1111/J.1741-1130.2006.00052.X
Guralnick MJ, 2005, J APPL RES INTELLECT, V18, P313, DOI 10.1111/j.1468-3148.2005.00270.x
Hastings Richard P, 2005, J Intellect Disabil, V9, P155, DOI 10.1177/1744629505053930
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2
Hastings RP, 2002, AM J MENT RETARD, V107, P116, DOI 10.1352/0895-8017(2002)107<0116:PPIFOC>2.0.CO;2
Hauser-Cram P, 2001, MONOGR SOC RES CHILD, V66, P1, DOI 10.1111/1540-5834.00151
Helbig S, 2006, SOC PSYCH PSYCH EPID, V41, P889, DOI 10.1007/s00127-006-0113-8
Helff C.M., 1998, FAM RELAT, V36, P263
Herrero MJ, 2003, GEN HOSP PSYCHIAT, V25, P277, DOI 10.1016/S0163-8343(03)00043-4
Hosmer D.W., 2004, WILEY SERIES PROBABI
Kayfitz AD, 2010, J APPL RES INTELLECT, V23, P337, DOI 10.1111/j.1468-3148.2009.00539.x
Keller D, 2004, AM J ORTHOPSYCHIAT, V74, P337, DOI 10.1037/0002-9432.74.3.337
Kleinbaum D. G., 2002, LOGISTIC REGRESSION
Lloyd T, 2008, J INTELL DISABIL RES, V52, P37, DOI 10.1111/j.1365-2788.2007.00974.x
Lowe B, 2004, J AFFECT DISORDERS, V78, P131, DOI 10.1016/S0165-0327(02)00237-9
MacDonald EE, 2010, J APPL RES INTELLECT, V23, P27, DOI 10.1111/j.1468-3148.2009.00546.x
MOES D, 1992, PSYCHOL REP, V71, P1272, DOI 10.2466/PR0.71.8.1272-1274
Olsson MB, 2002, J INTELL DISABIL RES, V46, P548, DOI 10.1046/j.1365-2788.2002.00414.x
PIVEN J, 1991, J AM ACAD CHILD PSY, V30, P471, DOI 10.1097/00004583-199105000-00019
Poole NA, 2006, GEN HOSP PSYCHIAT, V28, P55, DOI 10.1016/j.genhosppsych.2005.08.004
Pozo M.P, 2010, ADAPTACION PSICOLOGI
Rowbotham M, 2011, INT J DISABIL DEV ED, V58, P223, DOI 10.1080/1034912X.2011.598396
Saloviita T, 2003, J INTELL DISABIL RES, V47, P300, DOI 10.1046/j.1365-2788.2003.00492.x
Schreiber JB, 2006, J EDUC RES, V99, P323, DOI 10.3200/JOER.99.6.323-338
Skok A, 2006, J INTELLECT DEV DIS, V31, P53, DOI 10.1080/13668250600561929
Summers J. A., 1989, SUPPORT CAREGIVING F, P27
Summers J.A., 2007, INT J DISABIL DEV ED, V54, P319, DOI 10.1080/10349120701488848
Terol MC, 2007, ANSIEDAD ESTRES, V13, P163
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
Turnbull A. P., 2006, FAMILIES PROFESSIONA
Turnbull A.P., 1993, COGNITIVE COPING FAM
ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 50
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0033-5177
EI 1573-7845
J9 QUAL QUANT
JI Qual. Quant.
PD JUL
PY 2014
VL 48
IS 4
BP 2241
EP 2253
DI 10.1007/s11135-013-9889-2
PG 13
WC Social Sciences, Interdisciplinary; Statistics & Probability
SC Social Sciences - Other Topics; Mathematics
GA AI9JF
UT WOS:000337248200025
ER
PT J
AU de Boer, M
Spek, AA
Lobbestael, J
AF de Boer, Marion
Spek, Annelies A.
Lobbestael, Jill
TI Comparing cognitive functioning in schizophrenia and autism using
WAIS-III
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Schizophrenia; Autism; Cognitive functioning; WAIS-III; Processing speed
ID WORKING-MEMORY IMPAIRMENTS; ONSET SCHIZOPHRENIA; DISORDER; ADULTS;
NEUROCOGNITION; METAANALYSIS; INDIVIDUALS; PERFORMANCE; INTERVIEW;
DEFICITS
AB The main goal of this study was to investigate differences and similarities in general cognitive functioning between adults with schizophrenia and autism, because this has not been systematically investigated. We used a cross-sectional design to compare adults with schizophrenia (n = 27), with autism (n = 114) and a healthy control group (n = 30). Schizophrenia diagnoses were based on the Structured Clinical Interview for the DSM-IV Axis I (SCID-I) and behavioral symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Autism was diagnosed with a DSM-IV questionnaire for autism spectrum disorders and the Autistic Diagnostic Interview, revised version. The Wechsler Adult Intelligence Scale, third version (WAIS-III) was used to assess cognitive functions. All participants were between 18 and 65 years of age and had a minimum full scale intelligence of 80. Results showed that patients with schizophrenia scored significantly lower on processing speed than patients with autism and the healthy control group. Differences on other index scales were not found. In participants with schizophrenia a correlation was found between processing speed impairment and negative symptoms. Diagnosis could be predicted correctly with WAIS-III profile in 70.4% of the cases with schizophrenia compared to 56.7% of the healthy control group and 22.8% of the autism group. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [de Boer, Marion] Mental Hlth Inst GGZ Eindhoven, NL-5600 AX Eindhoven, Netherlands.
[Spek, Annelies A.] Mental Hlth Inst GGZ Eindhoven, Autism Dept, NL-5600 AX Eindhoven, Netherlands.
[Lobbestael, Jill] Maastricht Univ, Fac Psychol & Neurosci, NL-6200 MD Maastricht, Netherlands.
RP de Boer, M (reprint author), Mental Hlth Inst GGZ Eindhoven, POB 909,Dr Poletlaan 40, NL-5600 AX Eindhoven, Netherlands.
EM m.de.boer@ggze.nl; aa.spek@ggze.nl;
jill.lobbestael@maastrichtuniversity.nl
CR Allen DN, 2009, APPL NEUROPSYCHOL, V16, P262, DOI 10.1080/09084280903297727
Arnau RC, 2000, ASSESSMENT, V7, P237, DOI 10.1177/107319110000700304
Barch DA, 2003, CURR DIR PSYCHOL SCI, V12, P146, DOI 10.1111/1467-8721.01251
Bolte S, 2002, COMPR PSYCHIAT, V43, P325, DOI 10.1053/comp.2002.33490
Burbach JPH, 2009, TRENDS NEUROSCI, V32, P69, DOI 10.1016/j.tins.2008.11.002
Cohen JD, 1999, J ABNORM PSYCHOL, V108, P120, DOI 10.1037/0021-843X.108.1.120
de Ruiter C., 2000, M HANDLEIDING SCOREN
Den Boer J. A., 2002, BIOL PSYCHIAT
Dibben CRM, 2009, PSYCHOL MED, V39, P381, DOI 10.1017/S0033291708003887
Dickinson D, 2009, SCHIZOPHRENIA BULL, V35, P403, DOI 10.1093/schbul/sbn097
Dominguez MD, 2009, PSYCHOL BULL, V135, P157, DOI 10.1037/a0014415
DYKENS E, 1991, J AUTISM DEV DISORD, V21, P291, DOI 10.1007/BF02207326
Goldstein G, 2002, ARCH CLIN NEUROPSYCH, V17, P461, DOI 10.1016/S0887-6177(01)00129-9
Groenestijn M., 1999, GESTRUCTUREERD KLIN
Hallerback MU, 2012, PSYCHIAT RES, V198, P12, DOI 10.1016/j.psychres.2012.01.016
Happe F, 2012, GERONTOLOGY, V58, P70, DOI 10.1159/000329720
Holdnack J, 2011, ASSESSMENT, V18, P192, DOI 10.1177/1073191110394771
Horan WP, 2008, SCHIZOPHR RES, V103, P218, DOI 10.1016/j.schres.2008.02.014
Joyce M. E., 2005, BRIT J PSYCHIAT, V187, P516
Kanai C, 2012, RES AUTISM SPECT DIS, V6, P58, DOI 10.1016/j.rasd.2011.09.004
Kay S. R., 1987, POSITIVE NEGATIVE SY
King BH, 2011, BRAIN RES, V1380, P34, DOI 10.1016/j.brainres.2010.11.031
KOLVIN I, 1971, BRIT J PSYCHIAT, V118, P381, DOI 10.1192/bjp.118.545.381
Konstantareas MM, 2001, J AUTISM DEV DISORD, V31, P19, DOI 10.1023/A:1005605528309
Lee JH, 2005, J ABNORM PSYCHOL, V114, P599, DOI 10.1037/0021-843X.114.4.599
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
McGurk SR, 2004, J CLIN EXP NEUROPSYC, V26, P153, DOI 10.1076/jcen.26.2.153.28079
Medalia A, 1988, Arch Clin Neuropsychol, V3, P249, DOI 10.1016/0887-6177(88)90018-2
Peuskens J., 2002, TIJDSCHR PSYCHIAT, V44, P733
Pukrop R, 2003, SCHIZOPHR RES, V62, P259, DOI 10.1016/S0920-9964(02)00427-9
Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63
RUTTER M, 1972, J AUTISM CHILD SCHIZ, V2, P315, DOI 10.1007/BF01537622
Ryan JJ, 2001, ARCH CLIN NEUROPSYCH, V16, P151, DOI 10.1016/S0887-6177(99)00061-X
SKRE I, 1991, ACTA PSYCHIAT SCAND, V84, P167, DOI 10.1111/j.1600-0447.1991.tb03123.x
Spek A. A., 2009, GZ PSYCHOL, V1, P24
Spek AA, 2010, RES AUTISM SPECT DIS, V4, P709, DOI 10.1016/j.rasd.2010.01.009
Spek AA, 2008, J AUTISM DEV DISORD, V38, P782, DOI 10.1007/s10803-007-0446-5
SPOHN HE, 1989, J ABNORM PSYCHOL, V98, P367, DOI 10.1037/0021-843X.98.4.367
Tabares-Seisdedos R, 2009, MOL PSYCHIATR, V14, P563, DOI 10.1038/mp.2009.2
Tam WCC, 2004, J NERV MENT DIS, V192, P464, DOI 10.1097/01.nmd.0000131805.728552.a3
Tordjman S, 2008, BEHAV BRAIN SCI, V31, P278, DOI 10.1017/S0140525X08004391
VOLKMAR FR, 1991, AM J PSYCHIAT, V148, P1705
Wechsler D., 2012, WAIS 4 NL AFNAME SCO
Wechsler D, 2000, WAIS 3 NEDERLANDSTAL
Wechsler D, 2005, WAIS 3 NEDERLANDSTAL
Wilk CM, 2005, NEUROPSYCHOLOGY, V19, P778, DOI 10.1037/0894-4105.19.6.778
Wouters SGM, 2011, RES AUTISM SPECT DIS, V5, P1169, DOI 10.1016/j.rasd.2011.01.002
Zilles D, 2010, EUR ARCH PSY CLIN N, V260, P519, DOI 10.1007/s00406-010-0107-0
NR 48
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 737
EP 745
DI 10.1016/j.rasd.2014.03.001
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600001
ER
PT J
AU Ploog, BO
Brooks, PJ
Scharf, A
Aum, S
AF Ploog, Bertram O.
Brooks, Patricia J.
Scharf, Alexa
Aum, SangWeon
TI Perception of the prosody and content of sentences in an unfamiliar
language in children with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Receptive prosody; Language; Computer game; Attention;
Prioritization deficit hypothesis
ID HIGH-FUNCTIONING AUTISM; STIMULUS OVERSELECTIVITY; FACIAL EXPRESSIONS;
ADOLESCENTS; CUES; DISCRIMINATION; COMMUNICATION; COMPREHENSION;
PERFORMANCE; ATTENTION
AB Prior research suggests that children with autism spectrum disorders (ASD) show atypical patterns of attention to the prosody (intonation and emotional tone of voice) and content (words) of spoken sentences. Using a discrimination-choice procedure embedded in a custom-made videogame, we examined attention to these features of sentences in 15 children with ASD (ages 5 years, 5 months-18 years) and 15 age-matched typical controls (TYP). Using an unfamiliar language (German) to remove semantics, we assessed the role of meaning in promoting attention to content over prosody. As in a previous study with English sentences, TYP children attended to content to a greater extent than children with ASD while maintaining equivalent levels of discrimination based on prosody. However, in contrast to previous results, TYP children did not show a preference for enthusiastic over grouchy tone of voice, which suggests that the unfamiliar language rendered affective valence less salient. The results confirm intact perception of prosody in children with ASD, and a more selective pattern of attention to content in TYP children. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ploog, Bertram O.; Brooks, Patricia J.] CUNY Coll Staten Isl, Staten Isl, NY 10314 USA.
[Ploog, Bertram O.; Brooks, Patricia J.] CUNY, Grad Ctr, New York, NY USA.
[Scharf, Alexa] Columbia Univ, Teachers Coll, New York, NY 10027 USA.
[Aum, SangWeon] Eden II Sch Autist Children Inc, Staten Isl, NY USA.
RP Ploog, BO (reprint author), CUNY Coll Staten Isl, Dept Psychol, 4S-108,2800 Victory Blvd, Staten Isl, NY 10314 USA.
EM bertram.ploog@csi.cuny.edu; patricia.brooks@csi.cuny.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Arciuli J, 2012, Q J EXP PSYCHOL, V65, P1288, DOI 10.1080/17470218.2012.655700
Bhatara A, 2010, AUTISM RES, V3, P214, DOI 10.1002/aur.147
Boersma P., 2011, PRAAT DOING PHONETIC
Brennand R, 2011, RES AUTISM SPECT DIS, V5, P1567, DOI 10.1016/j.rasd.2011.03.002
Brooks PJ, 2013, RES AUTISM SPECT DIS, V7, P845, DOI 10.1016/j.rasd.2013.03.003
Chevallier C, 2010, J AUTISM DEV DISORD, V40, P1104, DOI 10.1007/s10803-010-0960-8
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
de Sonneville L M. J., 2013, EUROPEAN CHILD ADOLE
Doi H, 2013, J AUTISM DEV DISORD, V43, P2099, DOI 10.1007/s10803-013-1760-8
Dube WV, 1999, J APPL BEHAV ANAL, V32, P25, DOI 10.1901/jaba.1999.32-25
Eigsti IM, 2012, CHILD NEUROPSYCHOL, V18, P600, DOI 10.1080/09297049.2011.639757
Etzel B. C., 1981, BEHAV MODIFICATION C, P3
FLESHLER M, 1962, J EXP ANAL BEHAV, V5, P529, DOI 10.1901/jeab.1962.5-529
Grossman RB, 2012, RES AUTISM SPECT DIS, V6, P1150, DOI 10.1016/j.rasd.2012.03.006
Grossman RB, 2012, J AUTISM DEV DISORD, V42, P2546, DOI 10.1007/s10803-012-1511-2
Grossman RB, 2010, J SPEECH LANG HEAR R, V53, P778, DOI 10.1044/1092-4388(2009/08-0127)
HERRNSTEIN RJ, 1961, J EXP ANAL BEHAV, V4, P267, DOI 10.1901/jeab.1961.4-267
Jarvinen-Pasley A, 2008, DEVELOPMENTAL SCI, V11, P109, DOI 10.1111/j.1467-7687.2007.00644.x
KOEGEL RL, 1977, J EXP CHILD PSYCHOL, V24, P299, DOI 10.1016/0022-0965(77)90008-X
Li JPW, 2013, CLIN LINGUIST PHONET, V27, P18, DOI 10.3109/02699206.2012.734893
LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015
MCILVANE WJ, 1992, BEHAV ANALYST, V15, P89
SAHLEN B, 1993, EUR J DISORDER COMM, V28, P117
O'Connor K, 2012, NEUROSCI BIOBEHAV R, V36, P836, DOI 10.1016/j.neubiorev.2011.11.008
Paul R, 2005, J AUTISM DEV DISORD, V35, P861, DOI 10.1007/s10803-005-0031-8
Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
Ploog BO, 2009, RES AUTISM SPECT DIS, V3, P743, DOI 10.1016/j.rasd.2009.02.004
Ploog BO, 2007, J AUTISM DEV DISORD, V37, P1514, DOI 10.1007/s10803-006-0244-5
PLOOG BO, 1995, LEARN MOTIV, V26, P161, DOI 10.1016/0023-9690(95)90003-9
Ploog BO, 2011, BEHAV PROCESS, V87, P115, DOI 10.1016/j.beproc.2010.12.015
Ploog BO, 2010, J AUTISM DEV DISORD, V40, P1332, DOI 10.1007/s10803-010-0990-2
REYNOLDS GS, 1961, J EXP ANAL BEHAV, V4, P203, DOI 10.1901/jeab.1961.4-203
Samuelsson C., 2005, CHILD LANG TEACH THE, V21, P279, DOI 10.1191/0265659005ct293oa
SCHREIBMAN L, 1986, ANAL INTERVEN DEVEL, V6, P109, DOI 10.1016/0270-4684(86)90009-1
SCHREIBMAN L, 1975, J APPL BEHAV ANAL, V8, P91, DOI 10.1901/jaba.1975.8-91
Volkmar F. R., 2012, ENCY AUTISM SPECTRUM, P1
NR 37
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 775
EP 787
DI 10.1016/j.rasd.2014.03.014
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600005
ER
PT J
AU Nopprapun, M
Holloway, J
AF Nopprapun, Michael
Holloway, Jennifer
TI A comparison of fluency training and discrete trial instruction to teach
letter sounds to children with ASD: Acquisition and learning outcomes
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Fluency training (FT); Discrete trial instruction (DTI); Autism; Phonics
instruction
ID AUTISM SPECTRUM DISORDERS; BEHAVIORAL FLUENCY; OSHIELDS 2004; LITERACY;
INTERVENTIONS; INDIVIDUALS; KNOWLEDGE; STUDENTS; DOUGHTY; CHASE
AB The study investigated the efficacy of fluency training (FT) and discrete trial instruction (DTI) to teach phonic reading to individuals with Autism Spectrum Disorder (ASD), with particular emphasis on the acquisition of correct letter-sound correspondence and the learning outcomes of behavioural fluency instruction. An alternating-treatment design was employed to compare the treatment effects of FT versus DTI for the acquisition, retention, stability, endurance, and application of phonics in four children with ASD. The results showed that for two participants, FT was more efficient for the acquisition of correct letter-sound correspondence. For the remaining two participants, DTI resulted in more rapid acquisition. For all four participants, FT produced better results during post-test retention, endurance, stability, and application checks. The implications of these findings are discussed in relation to reading instruction, as well as the use of rate-building procedures with individuals with ASD. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Nopprapun, Michael; Holloway, Jennifer] Natl Univ Ireland, Galway, Ireland.
RP Holloway, J (reprint author), Natl Univ Ireland, Galway, Ireland.
EM jennifer.holloway@nuigalway.ie
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
BARLOW DH, 1979, J APPL BEHAV ANAL, V12, P199, DOI 10.1901/jaba.1979.12-199
Binder C, 2004, BEHAV ANALYST, V27, P281
Binder C, 1996, BEHAV ANALYST, V19, P163
Caravolas M, 2001, J MEM LANG, V45, P751, DOI 10.1006/jmla.2000.2785
Chall JS, 1997, ANN DYSLEXIA, V47, P257, DOI 10.1007/s11881-997-0029-3
Crosland K, 2012, BEHAV MODIF, V36, P251, DOI 10.1177/0145445512442682
Daneman M., 1991, HDB READING RES, P512
Dickinson DK, 2003, J EDUC PSYCHOL, V95, P465, DOI 10.1037/0022-0663.95.3.465
Doughty SS, 2004, BEHAV ANALYST, V27, P7
Fabrizio M. A., 2003, EUROPEAN J BEHAV ANA, V4, P23
Georgiou G. K., 2012, READ WRIT, P1
Gilliam JE, 2006, GILLIAM AUTISM RATIN
GOLDSTEIN G, 1994, J CLIN EXP NEUROPSYC, V16, P671, DOI 10.1080/01688639408402680
Gough PB, 1996, READING COMPREHENSION DIFFICULTIES, P1
Hanratty T., 2000, IS IT RATE NUM UNPUB
Happe FGE, 1997, BRIT J DEV PSYCHOL, V15, P1
Holding E, 2011, PSYCHOL SCHOOLS, V48, P166, DOI 10.1002/pits.20535
Huemer SV, 2010, J AUTISM DEV DISORD, V40, P485, DOI 10.1007/s10803-009-0892-3
Johnson KR, 1996, BEHAV ANALYST, V19, P281
JOHNSON KR, 1992, AM PSYCHOL, V47, P1475, DOI 10.1037//0003-066X.47.11.1475
Kazdin A. E., 1982, SINGLE CASE RES DESI
Kelly R. L., 1995, THESIS COLUMBIA U NE
Kerr K., 2003, EARLY CHILD DEV CARE, V173, P399, DOI 10.1080/0300443032000079087
Kubina RM, 2002, BEHAV INTERVENT, V17, P233, DOI 10.1002/bin.122
Kubina RM, 2009, INTERV SCH CLIN, V44, P131, DOI 10.1177/1053451208326054
Kubina RM, 2005, BEHAV ANALYST, V28, P73
Leaf R., 1999, WORK PROGR
Lindsley OR, 1996, BEHAV ANALYST, V19, P199
Lonigan CJ, 2000, DEV PSYCHOL, V36, P596, DOI 10.1037//0012-1649.36.5.596
MARTENS BK, 1985, PROF PSYCHOL-RES PR, V16, P191, DOI 10.1037/0735-7028.16.2.191
McBride-Chang C, 1999, MERRILL PALMER QUART, V45, P285
National Reading Panel, 2000, NIH PUB, V00-4754
Newman Bobby, 2009, Anal Verbal Behav, V25, P67
Roest E. R., 2008, COMP STUDY FLUENCY T
Scott J, 2000, STUDENTS AUTISM CHAR
Scruggs T. E., 2001, EXCEPTIONALITY, V9, P227, DOI DOI 10.1207/S15327035EX0904_5
Semel E., 2003, CLIN EVALUATION LANG, V4th
Singer-Dudek J., 2010, PSYCHOL REC, V55, P2
Weiss M. J., 2001, BEHAV ANAL TODAY, V2, P182
Weiss M. J., 2008, J PRECISION TEACHING, V24, P28
Weiss M. J., 2010, BEHAV ANAL TODAY, V11, P245
Weiss MJ, 2008, PRACT RESOUR MENT, P33, DOI 10.1016/B978-012373606-2.50004-8
Whalon KJ, 2009, FOCUS AUTISM DEV DIS, V24, P3, DOI 10.1177/1088357608328515
NR 44
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 788
EP 802
DI 10.1016/j.rasd.2014.03.015
PG 15
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600006
ER
PT J
AU Anzalone, SM
Tilmont, E
Boucenna, S
Xavier, J
Jouen, AL
Bodeau, N
Maharatna, K
Chetouani, M
Cohen, D
AF Anzalone, Salvatore Maria
Tilmont, Elodie
Boucenna, Sofiane
Xavier, Jean
Jouen, Anne-Lise
Bodeau, Nicolas
Maharatna, Koushik
Chetouani, Mohamed
Cohen, David
CA MICHELANGELO Study Grp
TI How children with autism spectrum disorder behave and explore the
4-dimensional (spatial 3D+time) environment during a joint attention
induction task with a robot
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Development; Social engagement; Joint
attention; Social robots
ID YOUNG-CHILDREN; SOCIAL ROBOTS; INDIVIDUALS; PEOPLE; CAREGIVERS;
IMITATION; TODDLERS; THERAPY; SPEECH; ORIENT
AB We aimed to compare, during a joint attention (JA) elicitation task, how children with autism spectrum disorder (ASD) and children with typical development (TD) behave and explore their 4 dimensional (meaning spatial 3D + time) when interacting with a human or with a robotic agent.
We built a system that employed a Nao robot and a perception system based on a RGB-D sensor (Kinect) to capture social engagement cues. A JA induction experiment was performed in which children with ASD (N = 16) and matched TD children (N = 16) had a 3-mm interaction with the robot or with a therapist. Nao induced JA by gazing; by gazing and pointing; and by gazing, pointing and vocalizing at pictures. Both groups of children performed well with the therapist. However, with Nao, both groups had lower JA scores, and the children with ASD had a significantly lower score than the TD children. We found that (i) multimodal JA induction was more efficient in both groups; (ii) the 3D spatial world gaze exploration showed less accuracy; and (iii) the trunk position in ASD showed less stability in the 4 dimensions compared to TD controls.
We conclude that, in ASD, JA skill depends on the interaction partner, and implies a higher motor and cognitive cost. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Anzalone, Salvatore Maria; Tilmont, Elodie; Boucenna, Sofiane; Jouen, Anne-Lise; Chetouani, Mohamed; Cohen, David] Univ Paris 06, Inst Syst Intelligents & Robot, F-75005 Paris, France.
[Tilmont, Elodie; Xavier, Jean; Bodeau, Nicolas; Cohen, David] Grp Hosp Pitie Salpetriere, AP HP, Dept Child & Adolescent Psychiat, F-75013 Paris, France.
[Tilmont, Elodie; Xavier, Jean; Bodeau, Nicolas; Cohen, David] Univ Paris 06, F-75013 Paris, France.
[Maharatna, Koushik] Univ Southampton, Southampton, Hants, England.
RP Anzalone, SM (reprint author), Univ Paris 06, Inst Syst Intelligents & Robot, Pyramide Tour 55,4 Pl Jussieu, F-75005 Paris, France.
EM anzalone@isir.upmc.fr
CR Bekele E., 2013, AUTISM
Boucenna S., 2014, COGNITIVE COMPUTATIO
Boucenna S., 2014, IEEE T AUTONOMOUS ME
Carpenter M., 1998, MONOGR SOC RES CHILD, V63, P1, DOI DOI 10.2307/1166214
Catarino A, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-1
Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
Cohen D, 2012, ANN MED-PSYCHOL, V170, P517, DOI 10.1016/j.amp.2012.06.019
Cohen D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061402
Crittendon J., 2013, J AUTISM DEV DISORDE
Dautenhahn K, 2003, ROBOTICA, V21, P443, DOI 10.1017/S0263574703004922
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
Dominey PF, 2004, J NEUROLINGUIST, V17, P121, DOI 10.1016/S0911-6044(03)00056-3
Doniec M. W., 2006, 6 IEEE RAS INT C HUM, P34
Duquette A, 2008, AUTON ROBOT, V24, P147, DOI 10.1007/s10514-007-9056-5
Emery NJ, 2000, NEUROSCI BIOBEHAV R, V24, P581, DOI 10.1016/S0149-7634(00)00025-7
Feil-Seifer D., 2011, EXPT ROBOTICS
Feil-Seifer D., 2011, 2011 6 ACM IEEE INT, P323
Fong T, 2003, ROBOT AUTON SYST, V42, P143, DOI 10.1016/S0921-8890(02)00372-X
Fujimoto I, 2011, INT J SOC ROBOT, V3, P349, DOI 10.1007/s12369-011-0116-9
Guinchat V, 2012, RES AUTISM SPECT DIS, V6, P589, DOI 10.1016/j.rasd.2011.10.005
Howlin P, 2013, J AM ACAD CHILD PSY, V52, P572, DOI 10.1016/j.jaac.2013.02.017
Jamal W., 2013, 35 ANN INT C IEEE EN, P2539
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Kozima H, 2009, INT J SOC ROBOT, V1, P3, DOI 10.1007/s12369-008-0009-8
Lanyi C. S., 2004, COMPUTERS HELPING PE, P625
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Maestro S, 2005, CHILD PSYCHIAT HUM D, V35, P383, DOI 10.1007/s10578-005-2695-x
Matson JL, 2012, RES AUTISM SPECT DIS, V6, P573, DOI 10.1016/j.rasd.2011.10.009
Meltzoff AN, 2010, NEURAL NETWORKS, V23, P966, DOI 10.1016/j.neunet.2010.09.005
Mundy P., 2003, EARLY SOCIAL COMMUNI
Nadel J, 2006, P 6 INT WORKSH EP RO
Nadel J., 2006, IMITATION SOCIAL MIN, P118
Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
Picard RW, 2010, EMOT REV, V2, P250, DOI 10.1177/1754073910364256
Pioggia G, 2005, IEEE T NEUR SYS REH, V13, P507, DOI 10.1109/TNSRE.2005.856076
Pioggia G, 2008, J CYBERTHERAPY REHAB, V1, P49
PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
Rogers S. J., 2009, EARLY SART DENVER MO
Roux AM, 2013, J AM ACAD CHILD PSY, V52, P931, DOI 10.1016/j.jaac.2013.05.019
Saint-Georges C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022393
Saint-Georges C., 2013, NEUROPSYCHIAT ENFAN, V61, P400
Saint-Georges C, 2010, RES AUTISM SPECT DIS, V4, P355, DOI 10.1016/j.rasd.2009.10.017
Scassellati B, 2007, SPR TRA ADV ROBOT, V28, P552
Scassellati B, 2012, ANNU REV BIOMED ENG, V14, P275, DOI 10.1146/annurev-bioeng-071811-150036
Serret S., 2012, NEUROPSYCHIAT ENFAN, V60, P59
Shotton J, 2011, PROC CVPR IEEE, P1297, DOI 10.1109/CVPR.2011.5995316
SIGMAN M, 1986, J CHILD PSYCHOL PSYC, V27, P647, DOI 10.1111/j.1469-7610.1986.tb00189.x
Szafir D., 2012, ACM CHI, P11
Tapus A, 2007, IEEE ROBOT AUTOM MAG, V14, P35, DOI 10.1109/MRA.2007.339605
Tomasello M., 1995, JOINT ATTENTION ITS, P103
Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
Warren Z. E., 2000, J AUTISM DEV DISORDE
Welch KC, 2010, INT J SOC ROBOT, V2, P391, DOI 10.1007/s12369-010-0063-x
NR 55
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 814
EP 826
DI 10.1016/j.rasd.2014.03.002
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600008
ER
PT J
AU Kristen, S
Rossmann, F
Sodian, B
AF Kristen, Susanne
Rossmann, Franziska
Sodian, Beate
TI Theory of own mind and autobiographical memory in adults with ASD
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Theory of mind; Autobiographical memory; Autism Spectrum Disorder
ID AUTISM SPECTRUM DISORDER; HIGH-FUNCTIONING AUTISM; STRANGE STORIES TEST;
ASPERGER-SYNDROME; EPISODIC MEMORY; AUTONOETIC CONSCIOUSNESS;
SELF-AWARENESS; QUOTIENT AQ; CHILDREN; ADOLESCENTS
AB While there is solid evidence of other-related theory of mind (TOM) deficits in autism, there is less research addressing self-related ToM impairments. To date, relations between self-related ToM and other cognitive skills related to representing own mental states such as autobiographical memory have scarcely been investigated. Thus, the purpose of this study was to investigate the differential relations of self-and other-related theory of mind skills and autobiographical memory in n = 20 adults with Autism Spectrum Disorder and n = 20 matched controls using standardized measures. The overall results indicated a specific relation between recalled episodic autobiographical memories on the episodic and semantic autobiographical memory interview and the performance on the mind-mindedness for oneself task in adults with ASD, which proved to be largely independent of verbal and nonverbal IQ. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Kristen, Susanne; Rossmann, Franziska; Sodian, Beate] Univ Munich, D-80802 Munich, Germany.
RP Kristen, S (reprint author), Univ Munich, Dept Psychol, Leopoldstr 13, D-80802 Munich, Germany.
EM susanne.kristen@psy.lmu.de
CR Adler N, 2010, PSYCHIAT RES, V178, P214, DOI 10.1016/j.psychres.2009.11.015
Baddeley A. D., 1992, THEORETICAL PERSPECT, V65, P13
Bamberg M, 2011, THEOR PSYCHOL, V21, P3, DOI 10.1177/0959354309355852
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
Baron-Cohen S., 2001, INT REV MENTAL RETAR, V23, P1
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Bauminger N, 2004, J DEV PHYS DISABIL, V16, P193, DOI 10.1023/B:JODD.0000026616.24896.c8
Bolte S, 2006, DIAGNOSTISCHES INTER
Bolte S., 2005, READING THE MIND IN
Bolte S., 2006, FRAGEBOGEN SOZIALEN
Boucher J, 2008, MEMORY AUTISM THEORY
Brent E, 2004, AUTISM, V8, P283, DOI 10.1177/1362361304045217
Carruthers P, 2009, BEHAV BRAIN SCI, V32, P121, DOI 10.1017/S0140525X09000545
Conway MA, 2000, PSYCHOL REV, V107, P261, DOI 10.1037//0033-295X.107.2.261
Crane L, 2012, J AUTISM DEV DISORD, V42, P2100, DOI 10.1007/s10803-012-1459-2
Crane L., 2014, AUTISM INT IN PRESS
Damon W., 1988, SELF UNDERSTANDING C
Dimaggio G., 2012, FRONT PSYCHOL, V3
DRITSCHEL BH, 1992, MEM COGNITION, V20, P133, DOI 10.3758/BF03197162
Fivush R, 2005, DEVELOPMENT OF SOCIAL COGNITION AND COMMUNICATION, P315
Fivush R, 2005, J COGN DEV, V6, P455, DOI 10.1207/s15327647jcd0604_1
Fletcher L, 2012, PHILOS T R SOC B, V367, P1366, DOI 10.1098/rstb.2011.0413
Freitag CM, 2007, Z KL PSYCH PSYCHOTH, V36, P280, DOI 10.1026/1616-3443.36.4.280
Frith U, 1999, MIND LANG, V14, P1
Goddard L, 2007, J AUTISM DEV DISORD, V37, P291, DOI 10.1007/s10803-006-0168-0
Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
Goldman A., 2006, SIMULATING MINDS PHI
Happe F, 2003, ANN NY ACAD SCI, V1001, P134, DOI 10.1196/annals.1279.008
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Harting C., 2000, WECHSLER GEDACHTNIS
Jolliffe T, 1999, J AUTISM DEV DISORD, V29, P395, DOI 10.1023/A:1023082928366
Kaland N, 2008, J AUTISM DEV DISORD, V38, P1112, DOI 10.1007/s10803-007-0496-8
Kaland N, 2005, EUR CHILD ADOLES PSY, V14, P73, DOI 10.1007/s00787-005-0434-2
Klein SB, 1999, SOC COGNITION, V17, P413, DOI 10.1521/soco.1999.17.4.413
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kopelman MD, 1990, AUTOBIOGRAPHICAL MEM
Lee A, 1998, J CHILD PSYCHOL PSYC, V39, P1131, DOI 10.1111/1469-7610.00417
Lehrl S., 2005, MEHRFACHWAHL WORTSCH
Lind SE, 2010, J ABNORM PSYCHOL, V119, P896, DOI 10.1037/a0020631
Lind SE, 2010, AUTISM, V14, P430, DOI 10.1177/1362361309358700
Lind SE, 2009, J AUTISM DEV DISORD, V39, P1231, DOI 10.1007/s10803-009-0735-2
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
McAdams D. P., 2001, REV GEN PSYCHOL, V5, P100, DOI DOI 10.1037/1089-2680.5.2.100
Meins E., 2010, MIND MINDEDNES UNPUB
Meins E, 2006, BRIT J DEV PSYCHOL, V24, P181, DOI 10.1348/026151005X80174
Millward C, 2000, J AUTISM DEV DISORD, V30, P15, DOI 10.1023/A:1005455926727
Moriguchi Y, 2006, NEUROIMAGE, V32, P1472, DOI 10.1016/j.neuroimage.2006.04.186
Naito M, 2003, J EXP CHILD PSYCHOL, V85, P312, DOI 10.1016/S0022-0965(03)00075-4
Nelson KD, 2004, PSYCHOL REV, V111, P486, DOI 10.1037/0033-295X.111.2.486
Nichols Shaun, 2003, MINDREADING INTEGRAT
O'Hare AE, 2009, J AUTISM DEV DISORD, V39, P916, DOI 10.1007/s10803-009-0699-2
Pennebaker J. W, 1997, OPENING HEALING POWE
Perner J, 2007, INFANT CHILD DEV, V16, P471, DOI 10.1002/icd.517
PERNER J, 1990, INTERACTIONS AMONG APTITUDES, STRATEGIES, AND KNOWLEDGE IN COGNITIVE PERFORMANCE, P3
PERNER J, 1995, J EXP CHILD PSYCHOL, V59, P516, DOI 10.1006/jecp.1995.1024
Piolino P, 2007, CONSCIOUS COGN, V16, P84, DOI 10.1016/j.concog.2005.09.010
Ruhl D, 2004, DIAGNOSTISCHE BEOBAC
Tanweer T, 2010, NEUROPSYCHOLOGIA, V48, P900, DOI 10.1016/j.neuropsychologia.2009.11.007
Tulving E., 1985, CAN PSYCHOL, V1, P1
Tulving E., 1972, ORG MEMORY, P381
Uddin LQ, 2011, NEUROCASE, V17, P201, DOI 10.1080/13554794.2010.509320
Vogeley K, 2001, NEUROIMAGE, V14, P170, DOI 10.1006/nimg.2001.0789
Wechsler D, 1987, MANUAL WECHSLER MEMO
Weiss RH., 2006, GRUNDINTELLIGENZTEST
Wheeler MA, 1997, PSYCHOL BULL, V121, P331, DOI 10.1037/0033-2909.121.3.331
White S, 2009, CHILD DEV, V80, P1097, DOI 10.1111/j.1467-8624.2009.01319.x
Williams D, 2010, DEVELOPMENTAL SCI, V13, P307, DOI 10.1111/j.1467-7687.2009.00885.x
Williams D, 2009, J AUTISM DEV DISORD, V39, P251, DOI 10.1007/s10803-008-0619-x
Williams DM, 2009, J AUTISM DEV DISORD, V39, P865, DOI 10.1007/s10803-009-0695-6
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 71
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 827
EP 837
DI 10.1016/j.rasd.2014.03.009
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600009
ER
PT J
AU Kuo, CC
Liang, KC
Tseng, CC
Gau, SSF
AF Kuo, Ching-Chih
Liang, Keng-Chen
Tseng, Christine Chifen
Gau, Susan Shur-Fen
TI Comparison of the cognitive profiles and social adjustment between
mathematically and scientifically talented students and students with
Asperger's syndrome
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Mathematically and scientifically talented; Asperger's syndrome;
Cognitive profiles; Social adjustment; Overexcitability traits
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; PSYCHOMETRIC PROPERTIES;
RESPONSIVENESS SCALE; DIAGNOSTIC INTERVIEW; CHINESE VERSION; CHILDREN;
INDIVIDUALS; ADOLESCENTS; OTHERS
AB This study compared the cognitive profiles and social adjustment of mathematically and scientifically talented (MST) students and students with Asperger's syndrome (AS) as compared to typically developing students. The applied instruments were the Wechsler Adult Intelligence Scale, 3rd version, Me Scale II, Social Responsiveness Scale (SRS), Adult Autism Spectrum Quotient (AQ), and autism diagnostic interview-revised. Eighty-four male students, aged 16-26, were assigned to four groups according to a talent in mathematics and science, diagnosis of AS, and the IQ level. The results showed that the high-IQ MST group exhibited balanced development in cognitive and affective aspects, the average-IQ MST group demonstrated weakness in perceptual organization and working memory, and problems with social awareness and socialness, and the AS group had weakness in performance IQ particularly in digit symbol-coding and symbol search and a wide-range of autistic-like social deficits (SRS) and autistic trait (AQ), and reported lower empathetic and higher emotional and creative overexcitability. Our findings support differential cognitive profiles and social adjustment between the MST and AS groups, and the influence of IQ on these manifestations in MST students. More attention should be paid to the social difficulty of average-IQ MST students in addition to AS students. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Kuo, Ching-Chih] Natl Taiwan Normal Univ, Dept Special Educ, Taipei 106, Taiwan.
[Liang, Keng-Chen; Gau, Susan Shur-Fen] Natl Taiwan Univ, Neurobiol & Cognit Sci Ctr, Dept Psychol, Taipei 100, Taiwan.
[Liang, Keng-Chen; Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Taipei 100, Taiwan.
[Tseng, Christine Chifen] Natl Taichung Univ Sci & Technol, Dept Appl English, Taichung 403, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, Taipei 100, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Sch Occupat Therapy, Coll Med, Taipei 100, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei 100, Taiwan.
RP Gau, SSF (reprint author), Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM gaushufe@ntu.edu.tw
CR Altman R., 1983, ROEPER REV, V6, P65
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen S., 2004, DEV NEUROREHABIL, V7, P73, DOI DOI 10.1080/13638490310001654790
Baska L. K., 1989, EXCELLENCE ED GIFTED, P15
BLACKBURN AC, 1986, J COUNS DEV, V64, P552
Buescher T. M., 1985, ROEPER REV, V8, P10
Chang H.-J., 2001, RES OVEREXCITABILITI
Chang HJ, 2013, LEARN INDIVID DIFFER, V23, P53, DOI 10.1016/j.lindif.2012.10.010
Chang H.-J., 2011, STUDY OVER EXCITABIL
Chang Y.-P., 2003, EMOTIONAL DEV LEVELS
Chen Y.-H., 2002, MANUAL WECHSLER ADUL
Chien WH, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-26
Chien WH, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-23
Chou MC, 2012, RES AUTISM SPECT DIS, V6, P665, DOI 10.1016/j.rasd.2011.09.010
Clark B., 1992, GROWING GIFTED DEV P
Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2005, SOCIAL RESPONSIVENES
Cowen T., 2009, CHRON HIGHER EDUC, V55
Cross T., 1996, GIFTED CHILD TODAY, V19, P22
Cross T., 1996, GIFTED CHILD TODAY, V19, P50
Dabrowski K., 1964, POSITIVE DISINTEGRAT
Dabrowski K., 1938, B I HIG PSYCHICZNEJ, V1, P3
Dabrowski K., 1970, MENTAL GROWTH POSITI
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Davis G. A., 1998, ED GIFTED TALENTED
Ehlers S, 1997, J CHILD PSYCHOL PSYC, V38, P207, DOI 10.1111/j.1469-7610.1997.tb01855.x
Gagne F., 2000, INT HDB GIFTEDNESS T, V2, P67, DOI DOI 10.1016/B978-008043796-5/50005-X
Gallagher S. A., 1986, ROEPER REV, V8, P115
Gau SSF, 2013, RES AUTISM SPECT DIS, V7, P349, DOI 10.1016/j.rasd.2012.10.004
Gau SSF, 2011, RES AUTISM SPECT DIS, V5, P809, DOI 10.1016/j.rasd.2010.09.010
Ghaziuddin M, 2004, J AUTISM DEV DISORD, V34, P279, DOI 10.1023/B:JADD.0000029550.19098.77
Gilchrist A, 2001, J CHILD PSYCHOL PSYC, V42, P227, DOI 10.1017/S0021963001006631
Gorsuch R. L., 1983, FACTOR ANAL
Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377
Happe F., 2010, AUTISM TALENT, V364
Huang P.-H., 2005, STUDY OVEREXCITABILI
Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
Kaland N, 2002, J CHILD PSYCHOL PSYC, V43, P517, DOI 10.1111/1469-7610.00042
Koyama T, 2007, PSYCHIAT CLIN NEUROS, V61, P99, DOI 10.1111/j.1440-1819.2007.01617.x
Kuo C.-C., 2012, J RES ED SCI, V57, P25
LARSEN RJ, 1986, J PERS SOC PSYCHOL, V51, P803, DOI 10.1037//0022-3514.51.4.803
Lewis R. B., 1992, ROEPER REV, V15, P25
Lewis WD, 1943, PEDAGOG SEMIN J GEN, V62, P301
Lin M.-H., 2003, OVEREXCITABILITIES P
Liu M.-J., 2008, B SPECIAL ED, V33, P73
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lovecky D., 1993, COUNSELING GIFTED TA, P29
Lovecky D. V., 1992, ROEPER REV, V15, P18
McLeod LD, 2001, TEST SCORING, P189
Mendaglio S., 1998, ANN C SOC ADV GIFT E, P17
MILLER NB, 1994, J EDUC GIFTED, V18, P20
Morrison I, 2007, CEREB CORTEX, V17, P2214, DOI 10.1093/cercor/bhl129
Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
Noterdaeme M, 2010, EUR CHILD ADOLES PSY, V19, P475, DOI 10.1007/s00787-009-0057-0
Ozonoff S., 2000, AUTISM, V4, P29, DOI DOI 10.1177/1362361300041003
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
Parker WD, 1997, AM EDUC RES J, V34, P545, DOI 10.3102/00028312034003545
Piirto J., 1994, TALENTED CHILDREN AD
Planche P, 2012, RES AUTISM SPECT DIS, V6, P939, DOI 10.1016/j.rasd.2011.12.009
Robinson N. M., 1991, HDB SPECIAL ED RES P, P57
Roedell W. C., 1984, ROEPER REV, V6, P127, DOI DOI 10.1080/02783198409552782
Roeper A., 1982, ROEPER REV, V5, P21
RUMSEY JM, 1990, J AUTISM DEV DISORD, V20, P155, DOI 10.1007/BF02284715
RUMSEY JM, 1988, J CLIN EXP NEUROPSYC, V10, P201, DOI 10.1080/01688638808408236
Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6
HARKNESS J, 1998, ZUMANACHRICHTEN SPEZ, V0003
SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
Siegel DJ, 1996, J AUTISM DEV DISORD, V26, P389, DOI 10.1007/BF02172825
Silverman L. K., 1990, ROEPER REV, V12, P171
Silverman L K., 1983, PRACTICAL GUIDE COUN, P6
Silverman L. K., 1993, COUNSELING GIFTED TA, P51
SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
Tsai L.-W., 2006, STUDY INFLUENTIAL FA
Volkmar F. R., 2005, HDB AUTISM PERVASIVE, V1
Vuilleumier P, 2007, NEUROPSYCHOLOGIA, V45, P174, DOI 10.1016/j.neuropsychologia.2006.06.003
Whitmore J. R., 1980, GIFTEDNESS CONFLICT
Xie Y. C., 2005, STUDY OVEREXCITABILI
NR 80
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 838
EP 850
DI 10.1016/j.rasd.2014.04.004
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600010
ER
PT J
AU Hagenmuller, F
Rossler, W
Wittwer, A
Haker, H
AF Hagenmuller, Florence
Roessler, Wulf
Wittwer, Amrei
Haker, Helene
TI Empathic resonance in Asperger syndrome
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Salivation; Autism spectrum disorder; Perception-action link; Contagion;
Coping; Empathy
ID TORONTO-ALEXITHYMIA-SCALE; SPECTRUM DISORDER; SEX-DIFFERENCES; AUTISM;
INDIVIDUALS; SALIVATION; IMITATION; VOLUNTARY; CHILDREN; DEFICITS
AB Reports on theory-of-mind deficits have led to the common belief that autism spectrum disorders (ASD) are associated with a lack of empathy. Resonance is a basic empathy-related process, linking two interacting individuals at the physiological level. Findings in ASD have been inconclusive regarding basic empathy. We investigated resonance at the autonomic level - the salivation-inducing effect of watching a person eating a lemon. Salivation-induction was assessed in 29 individuals with ASD and 28 control participants. Cotton rolls placed in the mouth were weighed before and after the video stimulation. Orientation to the stimulus was assessed with eye-tracking, autistic and empathic traits through self-reports. Group comparisons revealed lower salivation-induction in individuals with ASD. Linear regressions revealed different predictors of induction in each group: self-reported empathic fantasizing and age in ASD versus self-reported empathic concern plus orientation to the stimulus' face in the control. In both groups the social component was relevant: in ASD in terms of intellectual involvement with social contents and in controls in terms of the mere presence of a social vis-A-vis. Individuals with ASD may use explicitly acquired intellectual strategies whereas individuals with typical development can rely on intuitive processes for social responsivity. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Hagenmuller, Florence] Univ Zurich, Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, CH-8021 Zurich, Switzerland.
[Hagenmuller, Florence; Roessler, Wulf; Wittwer, Amrei; Haker, Helene] Univ Zurich, Coll Helveticum, CH-8021 Zurich, Switzerland.
[Hagenmuller, Florence; Roessler, Wulf; Wittwer, Amrei; Haker, Helene] ETH, Zurich, Switzerland.
[Haker, Helene] Univ Zurich, Inst Biomed Engn, Translat Neuromodeling Unit, CH-8021 Zurich, Switzerland.
[Roessler, Wulf] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil.
RP Hagenmuller, F (reprint author), Univ Zurich, Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, POB 1930, CH-8021 Zurich, Switzerland.
EM florence.hagenmuller@dgsp.uzh.ch
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bastiaansen JA, 2011, BIOL PSYCHIAT, V69, P832, DOI 10.1016/j.biopsych.2010.11.007
Bernhardt BC, 2012, ANNU REV NEUROSCI, V35, P1, DOI 10.1146/annurev-neuro-062111-150536
CACIOPPO JT, 1986, J PERS SOC PSYCHOL, V50, P260, DOI 10.1037//0022-3514.50.2.260
Davis M. H., 1980, CATALOG SELECTED DOC, V10, P85
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
DOPPELT JE, 1956, J CONSULT PSYCHOL, V20, P63, DOI 10.1037/h0044293
EISENBERG N, 1983, PSYCHOL BULL, V94, P100, DOI 10.1037/0033-2909.94.1.100
Falck-Ytter T, 2011, PROG BRAIN RES, V189, P209, DOI 10.1016/B978-0-444-53884-0.00026-9
Fink G. R., 2013, SOCIAL COGNITIVE AND
Gonzalez-Liencres C, 2013, NEUROSCI BIOBEHAV R, V37, P1537, DOI 10.1016/j.neubiorev.2013.05.001
Hagenmuller F., 1985, JUICY LEMONS FOR MEA
Haker Helene, 2010, Neuropsychiatr, V24, P151
Happe F, 1996, BRIT J DEV PSYCHOL, V14, P385
Klin A., 2002, AMERICAN JOURNAL OF, V159, P895
LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
LEVENSON RW, 1992, J PERS SOC PSYCHOL, V63, P234, DOI 10.1037/0022-3514.63.2.234
Morelli SA, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00160
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Magnee MJCM, 2007, J CHILD PSYCHOL PSYC, V48, P1122, DOI 10.1111/j.1469-7610.2007.01779.x
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216
NEMIAH JC, 1977, PSYCHOTHER PSYCHOSOM, V28, P199
NIRENBERG TD, 1982, BEHAV RES THER, V20, P405, DOI 10.1016/0005-7967(82)90102-4
Norscia I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028472
Pavlov I., 1927, CONDITIONED REFLEXES
Platek SM, 2003, COGNITIVE BRAIN RES, V17, P223, DOI 10.1016/S0926-6410(03)00109-5
POWER RP, 1970, BRIT J PSYCHOL, V61, P91
Preston SD, 2002, BEHAV BRAIN SCI, V25, P1
Provine RR, 2005, BEHAV BRAIN SCI, V28, P142
Schultz R., 2002, ARCH GEN PSYCHIAT, V59, P809
Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x
Senju A, 2009, J AUTISM DEV DISORD, V39, P1598, DOI 10.1007/s10803-009-0785-5
Senju A, 2007, BIOLOGY LETT, V3, P706, DOI 10.1098/rsbl.2007.0337
Senju A, 2013, BRAIN DEV-JPN, V35, P96, DOI 10.1016/j.braindev.2012.08.002
Thioux Marc, 2010, Dialogues Clin Neurosci, V12, P546
Wechsler D., 1981, MANUAL FOR THE WECHS
WHITE KD, 1978, PSYCHOPHYSIOLOGY, V15, P196, DOI 10.1111/j.1469-8986.1978.tb01363.x
Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
Papoiu A D P, 2011, Br J Dermatol, V164, P1299, DOI 10.1111/j.1365-2133.2011.10318.x
NR 44
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 851
EP 859
DI 10.1016/j.rasd.2014.04.008
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600011
ER
PT J
AU Lang, R
Machalicek, W
Rispoli, M
O'Reilly, M
Sigafoos, J
Lancioni, G
Peters-Scheffer, N
Didden, R
AF Lang, Russell
Machalicek, Wendy
Rispoli, Mandy
O'Reilly, Mark
Sigafoos, Jeff
Lancioni, Giulio
Peters-Scheffer, Nienke
Didden, Robert
TI Play skills taught via behavioral intervention generalize, maintain, and
persist in the absence of socially mediated reinforcement in children
with autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Play; Stereotypy; Lag schedules; Behavioral intervention
ID YOUNG-CHILDREN; PRETEND PLAY; VERBAL RESPONSIVENESS; SPECTRUM DISORDERS;
SYMBOLIC PLAY; DISABILITIES; STEREOTYPY; LEISURE; LIFE; PRESCHOOLERS
AB We measured generalization, maintenance and parent reports of child happiness in the context of a behavioral intervention to teach toy-play skills to three young children with autism. Lag schedules of reinforcement were implemented for two participants whose play did not initially generalize. The play skills intervention was conducted within the participants' early childhood classroom and the utility of teaching play as a means to reduce stereotypy within this setting was also evaluated. A multiple baseline design across participants demonstrated that play taught via behavioral intervention may be maintained after programmed reinforcement is discontinued, generalize across settings and toys (i.e., response and stimulus generalization), and occasion a decrease in stereotypy. Further, the occurrence of play in the absence of socially mediated reinforcement suggested that play taught via behavioral interventions may come to be automatically reinforced. Finally, parent responses on rating scales suggested that two of the participants were happier, in a better mood, and were more interested in appropriate toy-play following behavioral intervention. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Lang, Russell] SW Texas State Univ, Clin Autism Res Evaluat & Support, San Marcos, TX 78666 USA.
[Machalicek, Wendy] Univ Oregon, Coll Educ, Eugene, OR 97403 USA.
[Rispoli, Mandy] Texas A&M Univ, Dept Educ Psychol, College Stn, TX 77843 USA.
[Lang, Russell; O'Reilly, Mark] Univ Texas Austin, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
[Sigafoos, Jeff] Victoria Univ Wellington, Sch Educ Psychol, Wellington, New Zealand.
[Lancioni, Giulio] Univ Bari, Dept Neurosci & Sense Organs, Bari, Italy.
[Peters-Scheffer, Nienke; Didden, Robert] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands.
RP Lang, R (reprint author), Dept Curriculum & Instruct, 601 Univ Dr, San Marcos, TX 78666 USA.
EM russlang@txstate.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Barton EE, 2010, EXCEPT CHILDREN, V77, P85
Barton EE, 2008, TOP EARLY CHILD SPEC, V28, P109, DOI 10.1177/0271121408318799
Billstedt E, 2011, AUTISM, V15, P7, DOI 10.1177/1362361309346066
Bruckner CT, 2007, AUTISM, V11, P161, DOI 10.1177/1362361307075709
Camilleri A. P., 2005, J APPL BEHAV ANAL, V38, P111
Carr EG, 2003, AM J MENT RETARD, V108, P32, DOI 10.1352/0895-8017(2003)108<0032:UMRAMI>2.0.CO;2
Cooper J. O., 2007, APPL BEHAV ANAL
Venker CE, 2012, AUTISM, V16, P568, DOI 10.1177/1362361311413396
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Frost J. L., 2011, PLAY CHILD DEV
Hine JF, 2006, TOP EARLY CHILD SPEC, V26, P83, DOI 10.1177/02711214060260020301
Jobling A., 1988, EXCEPT CHILDREN, V35, P119
Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
Kazdin A. E., 1982, SINGLE CASE RES DESI
Kennedy CH, 2002, BEHAV MODIF, V26, P594, DOI 10.1177/014544502236652
Kleiber DA, 2002, LEISURE SCI, V24, P219, DOI 10.1080/01490400252900167
Koegel RL, 2009, J AUTISM DEV DISORD, V39, P1240, DOI 10.1007/s10803-009-0732-5
KOEGEL RL, 1974, J APPL BEHAV ANAL, V7, P521, DOI 10.1901/jaba.1974.7-521
Lang R, 2009, EDUC TRAIN DEV DISAB, V44, P481
Lang R, 2009, J APPL BEHAV ANAL, V42, P889, DOI 10.1901/jaba.2009.42-889
Lang R, 2011, RES AUTISM SPECT DIS, V5, P1296, DOI 10.1016/j.rasd.2011.02.012
Lang R, 2010, BEHAV MODIF, V34, P267, DOI 10.1177/0145445510370713
Lang R, 2010, DEV NEUROREHABIL, V13, P153, DOI 10.3109/17518421003607597
Lee R, 2007, PSYCHOL REC, V57, P429
Lee R, 2006, J AUTISM DEV DISORD, V36, P421, DOI 10.1007/s10803-006-0080-7
Licciardello C. C., 2008, ED TREATMENT CHILDRE, V31, P27, DOI DOI 10.1353/ETC.0.0010
Lifter K, 2005, J EARLY INTERVENTION, V27, P247, DOI 10.1177/105381510502700405
LIFTER K, 1993, J EARLY INTERVENTION, V17, P139
Lifter K, 2011, J EARLY INTERVENTION, V33, P281, DOI 10.1177/1053815111429465
Lifter K, 2011, INFANT YOUNG CHILD, V24, P225, DOI 10.1097/IYC.0b013e31821e995c
Luckett T, 2007, AUTISM, V11, P365, DOI 10.1177/1362361307078135
Lydon S, 2012, J DEV PHYS DISABIL, V24, P301, DOI 10.1007/s10882-012-9267-3
Manning MM, 2010, J AUTISM DEV DISORD, V40, P523, DOI 10.1007/s10803-009-0899-9
Martinez CK, 2013, J APPL BEHAV ANAL, V46, P549, DOI 10.1002/jaba.38
Mattell Inc, 2012, LITTL PEOPL PLAY SET
Mavropoulou S, 2011, J AUTISM DEV DISORD, V41, P913, DOI 10.1007/s10803-010-1116-6
McDuffie A, 2010, J SPEECH LANG HEAR R, V53, P1026, DOI 10.1044/1092-4388(2009/09-0023)
Mommy P. R., 2010, POP PALS AMUSEMENT P
Napolitano DA, 2010, J APPL BEHAV ANAL, V43, P265, DOI 10.1901/jaba.2010.43-265
Ninci J, 2013, DEV NEUROREHABIL, V16, P301, DOI 10.3109/17518423.2012.730557
Palmen A, 2011, DEV NEUROREHABIL, V14, P297, DOI 10.3109/17518423.2011.595433
Piaget J, 1962, PLAY DREAMS IMITATIO
Pierce-Jordan S, 2005, TOP EARLY CHILD SPEC, V25, P34, DOI 10.1177/02711214050250010401
Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
Rutherford MD, 2003, J AUTISM DEV DISORD, V33, P289, DOI 10.1023/A:1024406601334
Skinner B. F, 1953, SCI HUMAN BEHAV
STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
TILTON JR, 1964, PSYCHOL REP, V15, P967
Ullenhag A, 2012, DEV NEUROREHABIL, V15, P369, DOI 10.3109/17518423.2012.694915
Van Berckelaer-Onnes IA, 2003, AUTISM, V7, P415, DOI 10.1177/1362361303007004007
Volkert VM, 2009, J APPL BEHAV ANAL, V42, P145, DOI 10.1901/jaba.2009.42-145
Watson A. L., 2001, COMMUNICATION DISORD, V22, P135, DOI 10.1177/152574010102200303
WING L, 1977, J CHILD PSYCHOL PSYC, V18, P167, DOI 10.1111/j.1469-7610.1977.tb00426.x
NR 55
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 860
EP 872
DI 10.1016/j.rasd.2014.04.007
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600012
ER
PT J
AU Mishaal, RA
Ben-Itzchak, E
Zachor, DA
AF Mishaal, Ram A.
Ben-Itzchak, Esther
Zachor, Ditza A.
TI Age of autism spectrum disorder diagnosis is associated with child's
variables and parental experience
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder (ASD); Age of diagnosis; Social impairments;
Restricted and repetitive behaviors; Developmental regression; Adaptive
functioning; First born child
ID YOUNG-CHILDREN; FOLLOW-UP; REGRESSION; IDENTIFICATION; RECOGNITION;
RECURRENCE; BEHAVIORS; SEVERITY; SAMPLE; RISK
AB Early diagnosis of autism spectrum disorder (ASD) is highly important as it enables an early start to intervention. The current study examined familial (parental ages; education; having an older sibling) and child (gender; reported and observed autism symptoms severity; adaptive skills) related variables that might predict the age of ASD diagnosis. The study included 551 participants, age range 15-72 months, diagnosed with ASD who underwent comprehensive medical and behavioral assessment using standardized tests. Of the child's examined variables, the severity of the social interaction impairment reported by the parents and having a history of developmental regression was associated with an earlier age of ASD diagnosis. In contrast, the severity of the restricted and repetitive behaviors was associated with delayed age of ASD diagnosis. Vineland Adaptive Behavior Scales scores lower or higher than the group's mean (70 points) were associated with a relatively delayed age of ASD diagnosis. Of the familial variables, only having an older sibling was associated with an earlier diagnosis. Professionals should be aware that subtle signs of ASD, developmental delay and close to normal adaptive functioning might delay age of ASD diagnosis. Educating parents on "red flags" for ASD and periodic surveillance in early childhood are important. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Mishaal, Ram A.; Ben-Itzchak, Esther; Zachor, Ditza A.] Assaf Harofeh Med Ctr, Dept Pediat, Autism Ctr, IL-70300 Zerifin, Israel.
[Ben-Itzchak, Esther] Ariel Univ, Dept Commun Disorders, IL-40700 Ariel, Israel.
[Zachor, Ditza A.] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
RP Zachor, DA (reprint author), 12 Hatizmoret St, IL-55556 Kiryat Ono, Israel.
EM dzachor@asaf.health.gov.il
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baghdadli A, 2003, EUR CHILD ADOLES PSY, V12, P122, DOI 10.1007/s00787-003-0314-6
Ben-Itzchak E, 2013, AUTISM RES, V6, P596, DOI 10.1002/aur.1319
Ben Itzchak E, 2011, RES AUTISM SPECT DIS, V5, P345, DOI 10.1016/j.rasd.2010.04.018
Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
Chawarska K, 2007, J AUTISM DEV DISORD, V37, P62, DOI 10.1007/s10803-006-0330-8
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
Fountain C, 2011, J EPIDEMIOL COMMUN H, V65, P503, DOI 10.1136/jech.2009.104588
Gardiner E, 2012, RES DEV DISABIL, V33, P2177, DOI 10.1016/j.ridd.2012.06.014
Giarelli E, 2010, DISABIL HEALTH J, V3, P107, DOI 10.1016/j.dhjo.2009.07.001
Goin-Kochel RP, 2006, AUTISM, V10, P439, DOI 10.1177/1362361306066601
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Guinchat V, 2012, RES AUTISM SPECT DIS, V6, P589, DOI 10.1016/j.rasd.2011.10.005
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kishore MT, 2011, RES AUTISM SPECT DIS, V5, P157, DOI 10.1016/j.rasd.2010.03.005
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Latif AHA, 2007, AUTISM, V11, P479, DOI 10.1177/1362361307083256
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Lord C., 1999, AUTISM DIAGNOSTIC OB
Lord C., 2012, J AUTISM DEV DISORD, P1719
Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
MacDonald R, 2007, RES DEV DISABIL, V28, P266, DOI 10.1016/j.ridd.2006.01.004
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P1319, DOI 10.1016/j.rasd.2011.03.006
Mooney EL, 2006, EUR CHILD ADOLES PSY, V15, P12, DOI 10.1007/s00787-006-0499-6
Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
Parr JR, 2011, J AUTISM DEV DISORD, V41, P332, DOI 10.1007/s10803-010-1055-2
Pinto-Martin J., 2004, CURR TREAT OPTION NE, V6, P391, DOI 10.1007/s11940-996-0030-x
ROGERS SJ, 1990, J AM ACAD CHILD PSY, V29, P863, DOI 10.1097/00004583-199011000-00004
Rhoades Rachel A, 2007, BMC Pediatr, V7, P37, DOI 10.1186/1471-2431-7-37
Schopler E, 2002, CHILDHOOD AUTISM RAT
Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
Shumway S, 2011, J AUTISM DEV DISORD, V41, P1727, DOI 10.1007/s10803-011-1203-3
Sparrow S., 2005, VINELAND 2 ADAPTIVE, V2nd
Sparrow S, 1984, VINELAND ADAPTIVE BE
Stefanatos GA, 2008, NEUROPSYCHOL REV, V18, P305, DOI 10.1007/s11065-008-9073-y
Turygin N, 2014, RES AUTISM SPECT DIS, V8, P53, DOI 10.1016/j.rasd.2013.10.008
Watt N, 2008, J AUTISM DEV DISORD, V38, P1518, DOI 10.1007/s10803-007-0532-8
Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
Zachor DA, 2011, RES DEV DISABIL, V32, P2950, DOI 10.1016/j.ridd.2011.05.007
NR 45
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 873
EP 880
DI 10.1016/j.rasd.2014.04.001
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600013
ER
PT J
AU Chien, YL
Gau, SSF
Chiu, YN
Tsai, WC
Shang, CY
Wu, YY
AF Chien, Yi-Ling
Gau, Susan Shur-Fen
Chiu, Yen-Nan
Tsai, Wen-Che
Shang, Chi-Yung
Wu, Yu-Yu
TI Impaired sustained attention, focused attention, and vigilance in youths
with autistic disorder and Asperger's disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autistic disorder; Asperger's disorder; ADHD; Oppositional symptoms;
Attention performance; Continuous performance test
ID DEFICIT HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
HIGH-FUNCTIONING AUTISM; CONTINUOUS PERFORMANCE-TEST;
DEFICIT/HYPERACTIVITY DISORDER; PSYCHOMETRIC PROPERTIES; SPECTRUM
DISORDERS; CHINESE VERSION; EXECUTIVE FUNCTIONS; CHILDREN
AB The study compared the attention-deficit/hyperactivity disorder (ADHD) related clinical symptoms and a wide-ranging attention performance in 216 youths with autistic disorder (autism), 138 youths with Asperger's disorder (AD) and 255 typically-developing youths. The diagnosis of autism and AD were made based on the clinical assessments according to the DSM-IV criteria and confirmed by the Autism Diagnostic Interview-Revised. All the participants were assessed with the Conners' Continuous Performance Test (CCPT) and the questionnaires about ADHD, oppositional, and autistic symptoms. All indices of the CCPT were analyzed based on a recently developed factor structure, including focused attention, cognitive impulsivity, sustained attention, and vigilance. We found that compared with typically-developing youths, youths with autism and AD showed more inattentive, hyperactive/impulsive, and oppositional symptoms, and performed worse in focused attention and sustained attention as assessed by the CCPT. Youths with AD also showed more oppositional symptoms than youths with autism. Moreover, youths with autism had poorer focused attention than youths with AD; but, youths with AD had more impaired sustained attention. Our results validate different manifestations of ADHD-related symptoms and attention performance between youths with autism and youths with AD and suggest intervention for youths with autism spectrum disorders should consider these specific measures. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Chien, Yi-Ling; Gau, Susan Shur-Fen; Chiu, Yen-Nan; Tsai, Wen-Che; Shang, Chi-Yung] Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, Taipei 10002, Taiwan.
[Chien, Yi-Ling; Gau, Susan Shur-Fen] Natl Taiwan Univ, Coll Med, Grad Inst Brain & Mind Sci, Taipei 10764, Taiwan.
[Chien, Yi-Ling; Gau, Susan Shur-Fen] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 10764, Taiwan.
[Wu, Yu-Yu] Chang Gung Univ, Coll Med, Linkou Med Ctr, Dept Psychiat,Chang Gung Mem Hosp, Taoyuan, Taiwan.
RP Gau, SSF (reprint author), Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM gaushufe@ntu.edu.tw
CR Allen G, 2003, AM J PSYCHIAT, V160, P262, DOI 10.1176/appi.ajp.160.2.262
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
Buchmann J, 2011, WORLD J BIOL PSYCHIA, V12, P35, DOI 10.3109/15622975.2011.600354
Chiang HL, 2013, RES DEV DISABIL, V34, P2986, DOI 10.1016/j.ridd.2013.06.020
Chien WH, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-26
Chien WH, 2010, PROG NEURO-PSYCHOPH, V34, P189, DOI 10.1016/j.pnpbp.2009.11.004
Chien WH, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-23
Chien YL, 2012, PSYCHIAT GENET, V22, P46, DOI 10.1097/YPG.0b013e32834915ae
Conners C., 2000, CONNERS CONTINUOUS P
Cornblatt BA, 2001, AM J MED GENET, V105, P11, DOI 10.1002/1096-8628(20010108)105:1<11::AID-AJMG1045>3.0.CO;2-G
COURCHESNE E, 1989, J AUTISM DEV DISORD, V19, P1, DOI 10.1007/BF02212714
Egeland J, 2010, J ATTEN DISORD, V13, P347, DOI 10.1177/1087054709332477
Epstein JN, 2003, J ABNORM CHILD PSYCH, V31, P543, DOI 10.1023/A:1025405216339
Fombonne E, 2001, J AM ACAD CHILD PSY, V40, P820, DOI 10.1097/00004583-200107000-00017
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3
GARRETSON HB, 1990, J AUTISM DEV DISORD, V20, P101, DOI 10.1007/BF02206860
Gau SSF, 2005, AM J PSYCHIAT, V162, P1344, DOI 10.1176/appi.ajp.162.7.1344
Gau SSF, 2008, INT J METH PSYCH RES, V17, P35, DOI 10.1002/mpr.237
Gau SSF, 2010, INT J NEUROPSYCHOPH, V13, P243, DOI 10.1017/S1461145709990836
Gau SSF, 2013, RES AUTISM SPECT DIS, V7, P349, DOI 10.1016/j.rasd.2012.10.004
Gau SSF, 2011, RES AUTISM SPECT DIS, V5, P809, DOI 10.1016/j.rasd.2010.09.010
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
GILLBERG C, 1989, DEV MED CHILD NEUROL, V31, P520
Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
Gu SLH, 2013, RES DEV DISABIL, V34, P3709, DOI 10.1016/j.ridd.2013.07.025
Guttmann-Steinmetz S, 2009, J AUTISM DEV DISORD, V39, P976, DOI 10.1007/s10803-009-0706-7
Huang W. L., 2013, PSYCHOL MED, V8, P1
Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019
Kanaka N, 2008, PSYCHIAT CLIN NEUROS, V62, P135, DOI 10.1111/j.1440-1819.2008.01746.x
Kilincaslan A, 2010, TURK PSIKIYATR DERG, V21, P289
Lau WYP, 2013, RES DEV DISABIL, V34, P294, DOI 10.1016/j.ridd.2012.08.005
Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
Lin H. Y., 2013, PSYCHOL MED, P1
Tsai FJ, 2013, J FORMOS MED ASSOC, V112, P396, DOI 10.1016/j.jfma.2011.08.022
Lo YC, 2013, AUTISM RES, V6, P561, DOI 10.1002/aur.1315
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lundervold A. J., 2012, J ATTENTION DISORDER
Markovska-Simoska S, 2009, Prilozi, V30, P167
Murray MJ, 2010, CURR PSYCHIAT REP, V12, P382, DOI 10.1007/s11920-010-0145-3
Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
Ozonoff S., 2000, AUTISM, V4, P29, DOI DOI 10.1177/1362361300041003
Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650
Posey DJ, 2007, BIOL PSYCHIAT, V61, P538, DOI 10.1016/j.biopsych.2006.09.028
Rinehart NJ, 2002, AUST NZ J PSYCHIAT, V36, P762, DOI 10.1046/j.1440-1614.2002.01097.x
Schatz AM, 2002, J AUTISM DEV DISORD, V32, P333, DOI 10.1023/A:1016339104165
Shang CY, 2011, PROG NEURO-PSYCHOPH, V35, P421, DOI 10.1016/j.pnpbp.2010.08.016
Shang CY, 2013, PSYCHOL MED, V43, P1093, DOI 10.1017/S0033291712001869
SIEGEL BV, 1995, SCHIZOPHR RES, V17, P85, DOI 10.1016/0920-9964(95)00033-I
Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
Swaab-Barneveld H, 2000, J AM ACAD CHILD PSY, V39, P651, DOI 10.1097/00004583-200005000-00020
Swanson JM, 2001, J AM ACAD CHILD PSY, V40, P168, DOI 10.1097/00004583-200102000-00011
Thede LL, 2007, J AUTISM DEV DISORD, V37, P847, DOI 10.1007/s10803-006-0212-0
Tonge B. J., 1999, AUTISM, V3, P117, DOI DOI 10.1177/1362361399003002003
Willcutt EG, 2005, BIOL PSYCHIAT, V57, P1336, DOI 10.1016/j.biopsych.2005.02.006
Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
Wu YH, 2014, HUM BRAIN MAPP, V35, P199, DOI 10.1002/hbm.22169
Yang HN, 2013, RES DEV DISABIL, V34, P3168, DOI 10.1016/j.ridd.2013.06.011
Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1
NR 63
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 881
EP 889
DI 10.1016/j.rasd.2014.04.006
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600014
ER
PT J
AU Goin-Kochel, RP
Esler, AN
Kanne, SM
Hus, V
AF Goin-Kochel, Robin P.
Esler, Amy N.
Kanne, Stephen M.
Hus, Vanessa
TI Developmental regression among children with autism spectrum disorder:
Onset, duration, and effects on functional outcomes
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Regression; Skill loss; Cognition; Adaptive
functioning; Outcomes
ID LANGUAGE; PHENOTYPE; PATTERNS
AB Studies using varied methods report that developmental regression occurs in a sizeable proportion of children with autism spectrum disorder (ASD). Findings are equivocal as to whether regression is associated with poorer cognitive and adaptive functioning. This study examined retrospective parent report in 2105 Simons Simplex Collection participants with ASD. Children were classified as having "full" or "subthreshold" losses on language and/or other skills using items from the Autism Diagnostic Interview-Revised (ADI-R) and a supplemental interview to capture more subtle regressions. Overall, 36.9% of children had some type of regression (27.8% language, 27.0% other-skill loss), with the supplemental interview capturing 11.7% of losses that would have been missed using the ADI-R alone. This figure is consistent with previous parent-report studies but lower than clinician-observed rates in prospective investigations. Early language losses either full or subthreshold and full other-skill losses appear to be associated with more deleterious outcomes by middle childhood. Findings may signify the need for more immediate and/or intense therapies for children who have even minor skill losses, particularly in language skills. Results further demonstrate the utility of an expanded set of additional queries with slightly modified criteria to capture such early, subtle losses. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Goin-Kochel, Robin P.; Kanne, Stephen M.] Texas Childrens Hosp, Baylor Coll Med, Autism Ctr, Houston, TX 77054 USA.
[Esler, Amy N.] Univ Minnesota, Autism Spectrum & Neurodev Disorders Clin, Minneapolis, MN 55414 USA.
[Hus, Vanessa] Univ Michigan, Dept Psychol, Ann Arbor, MI USA.
RP Goin-Kochel, RP (reprint author), Texas Childrens Hosp, Autism Ctr, 8080 N,Stadium Dr,Suite 180, Houston, TX 77054 USA.
EM kochel@bcm.edu; esle0007@umn.edu; kannest@health.missouri.edu;
vhus@umich.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baird G, 2008, J AUTISM DEV DISORD, V38, P1827, DOI 10.1007/s10803-008-0571-9
Barger BD, 2013, J AUTISM DEV DISORD, V43, P817, DOI 10.1007/s10803-012-1621-x
Bernabei P, 2007, J AUTISM DEV DISORD, V37, P580, DOI 10.1007/s10803-006-0201-3
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Deprey L, 2011, J AUTISM DEV DISORD, V41, P1727
Elliott C., 2007, DIFFERENTIAL ABILITY
Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
Fombonne E, 2001, PEDIATRICS, V8, P991
Giannotti F, 2008, J AUTISM DEV DISORD, V38, P1888, DOI 10.1007/s10803-008-0584-4
Goin-Kochel R. P., 2005, FOCUS AUTISM OTHER D, V20, P169, DOI 10.1177/10883576050200030501
Goldberg WA, 2003, J AUTISM DEV DISORD, V33, P607, DOI 10.1023/B:JADD.0000005998.47370.ef
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Hansen RL, 2008, AMBUL PEDIATR, V8, P25, DOI 10.1016/j.ambp.2007.08.006
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
Hus V, 2011, J CHILD PSYCHOL PSYC, V52, P753, DOI 10.1111/j.1469-7610.2011.02398.x
Kalb LG, 2010, J AUTISM DEV DISORD, V40, P1389, DOI 10.1007/s10803-010-0998-7
Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
Lord C., 1999, AUTISM DIAGNOSTIC OB
Lord C, 2004, J CHILD PSYCHOL PSYC, V45, P936, DOI 10.1111/j.1469-7610.2004.t01-1-00287.x
Matson JL, 2010, DEV NEUROREHABIL, V13, P37, DOI 10.3109/17518420903107984
Meilleur AAS, 2009, J INTELL DISABIL RES, V53, P115, DOI 10.1111/j.1365-2788.2008.01134.x
Mullen E, 1995, MULLEN SCALES EARLY
Ozonoff S, 2005, AUTISM, V9, P461, DOI 10.1177/1362361305057880
Ozonoff S, 2011, J AM ACAD CHILD PSY, V50, P796, DOI 10.1016/j.jaac.2011.03.012
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Parr JR, 2011, J AUTISM DEV DISORD, V41, P332, DOI 10.1007/s10803-010-1055-2
Pickles A, 2009, J CHILD PSYCHOL PSYC, V50, P843, DOI 10.1111/j.1469-7610.2008.02032.x
Richler J, 2006, J AUTISM DEV DISORD, V36, P299, DOI 10.1007/s10803-005-0070-1
Rogers SJ, 2004, MENT RETARD DEV D R, V10, P139, DOI 10.1002/mrdd.20027
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stefanatos GA, 2008, NEUROPSYCHOL REV, V18, P305, DOI 10.1007/s11065-008-9073-y
Wechsler D., 2003, WECHSLER INTELLIGENC
Wechsler D, 1999, WECHSLER ABBREVIATED
Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6
Wiggins LD, 2009, AUTISM, V13, P357, DOI 10.1177/1362361309105662
Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
NR 40
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 890
EP 898
DI 10.1016/j.rasd.2014.04.002
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600015
ER
PT J
AU Hanley, M
Riby, DM
McCormack, T
Carty, C
Coyle, L
Crozier, N
Robinson, J
McPhillips, M
AF Hanley, Mary
Riby, Deborah M.
McCormack, Teresa
Carty, Clare
Coyle, Lisa
Crozier, Naomi
Robinson, Johanna
McPhillips, Martin
TI Attention during social interaction in children with autism: Comparison
to specific language impairment, typical development, and links to
social cognition
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Specific language impairment; Eye-tracking; Social interaction;
Implicit mentalising
ID SPECTRUM DISORDERS; WILLIAMS-SYNDROME; EYE-MOVEMENTS; COMMUNICATION
IMPAIRMENTS; ATYPICAL DEVELOPMENT; GAZE AVERSION; TRACKING; FACES; MIND;
INDIVIDUALS
AB Eye-tracking studies have shown how people with autism spend significantly less time looking at socially relevant information on-screen compared to those developing typically. This has been suggested to impact on the development of socio-cognitive skills in autism. We present novel evidence of how attention atypicalities in children with autism extend to real-life interaction, in comparison to typically developing (TD) children and children with specific language impairment (SLI). We explored the allocation of attention during social interaction with an interlocutor, and how aspects of attention (awareness checking) related to traditional measures of social cognition (false belief attribution). We found divergent attention allocation patterns across the groups in relation to social cognition ability. Even though children with autism and SLI performed similarly on the socio-cognitive tasks, there were syndrome-specific atypicalities of their attention patterns. Children with SLI were most similar to TD children in terms of prioritising attention to socially pertinent information (eyes, face, awareness checking). Children with autism showed reduced attention to the eyes and face, and slower awareness checking. This study provides unique and timely insight into real-world social gaze (a)typicality in autism, SLI and typical development, its relationship to socio-cognitive ability, and raises important issues for intervention. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Hanley, Mary; Riby, Deborah M.] Univ Durham, Dept Psychol, Durham DH1 3LE, England.
[McCormack, Teresa; Carty, Clare; Coyle, Lisa; Crozier, Naomi; Robinson, Johanna; McPhillips, Martin] Queens Univ Belfast, Sch Psychol, Belfast BT7 1NN, Antrim, North Ireland.
RP Hanley, M (reprint author), Univ Durham, Dept Psychol, Sci Labs, S Rd, Durham DH1 3LE, England.
EM mary.hanley@durham.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P131, DOI 10.1007/s10803-005-0046-1
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
Bishop DVM, 2005, AUTISM, V9, P7, DOI 10.1177/1362361305049027
Boraston Z, 2007, J PHYSIOL-LONDON, V581, P893, DOI 10.1113/jphysiol.2007.133587
Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007
Burack JA, 2004, J AUTISM DEV DISORD, V34, P65, DOI 10.1023/B:JADD.0000018076.90715.00
Celani G, 2002, AUTISM, V6, P93, DOI 10.1177/1362361302006001007
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Doherty-Sneddon G, 2013, RES DEV DISABIL, V34, P616, DOI 10.1016/j.ridd.2012.09.022
Doherty-Sneddon G, 2012, J CHILD PSYCHOL PSYC, V53, P420, DOI 10.1111/j.1469-7610.2011.02481.x
DohertySneddon G, 1996, J CHILD PSYCHOL PSYC, V37, P949, DOI 10.1111/j.1469-7610.1996.tb01492.x
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Falck-Ytter T, 2010, DEVELOPMENTAL SCI, V13, P864, DOI 10.1111/j.1467-7687.2009.00942.x
Farrant BM, 2006, CHILD DEV, V77, P1842, DOI 10.1111/j.1467-8624.2006.00977.x
Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
Franchak JM, 2011, CHILD DEV, V82, P1738, DOI 10.1111/j.1467-8624.2011.01670.x
Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2
Frith CD, 2006, NEURON, V50, P531, DOI 10.1016/j.neuron.2006.05.001
Hanley M., 2012, AUTISM, V17, P754, DOI [10.1177/1362361312456746, DOI 10.1177/1362361312456746]
Harris P., 1989, COGNITION EMOTION, V3, P379, DOI DOI 10.1080/02699938908412713
Hosozawa M., 2012, PEDIATRICS, V129, P1453
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Hughes C, 2000, J CHILD PSYCHOL PSYC, V41, P483, DOI 10.1017/S0021963099005533
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Kelly DJ, 2013, DEVELOPMENTAL SCI, V16, P56, DOI 10.1111/j.1467-7687.2012.01188.x
KLEINKE CL, 1986, PSYCHOL BULL, V100, P78, DOI 10.1037//0033-2909.100.1.78
Klin A, 2008, J AM ACAD CHILD PSY, V47, P362, DOI 10.1097/CHI.0b013e3181648dd1
Klin A, 2008, DEVELOPMENTAL SCI, V11, P40, DOI 10.1111/j.1467-7687.2007.00608.x
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
Kuhn G, 2010, PSYCHOL SCI, V21, P1487, DOI 10.1177/0956797610383435
MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
Mundy P., 2003, MANUAL ABRIDGED EARL
Nadig A, 2010, NEUROPSYCHOLOGIA, V48, P2730, DOI 10.1016/j.neuropsychologia.2010.05.020
Nakano T, 2010, P ROY SOC B-BIOL SCI, V277, P2935, DOI 10.1098/rspb.2010.0587
Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
Paynter J, 2010, RES AUTISM SPECT DIS, V4, P377, DOI 10.1016/j.rasd.2009.10.005
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7
Pruett JR, 2011, J AUTISM DEV DISORD, V41, P715, DOI 10.1007/s10803-010-1090-z
Riby D, 2009, J INTELL DISABIL RES, V53, P169, DOI 10.1111/j.1365-2788.2008.01142.x
Riby DM, 2012, DEVELOPMENTAL SCI, V15, P281, DOI 10.1111/j.1467-7687.2011.01125.x
Riby DM, 2012, J CLIN EXP NEUROPSYC, V34, P385, DOI 10.1080/13803395.2011.645019
Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z
Rice K, 2012, J AM ACAD CHILD PSY, V51, P238, DOI 10.1016/j.jaac.2011.12.017
Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
Sasson NJ, 2008, AUTISM RES, V1, P31, DOI 10.1002/aur.4
Semel E., 2006, CLIN EVALUATION LANG, V4th
Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Striano T., 2009, SOCIAL COGNITION DEV, P237
van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055
Varghese LA, 2012, JARO-J ASSOC RES OTO, V13, P359, DOI 10.1007/s10162-012-0314-7
Volkmar F., 1997, HDB AUTISM PERVASIVE, P173
Wechsler D., 2006, WECHSLER NONVERBAL S
WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
WIMMER H, 1991, BRIT J DEV PSYCHOL, V9, P125
Yarbus A. L., 1967, EYE MOVEMENTS VISION
NR 63
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 908
EP 924
DI 10.1016/j.rasd.2014.03.020
PG 17
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600017
ER
PT J
AU Jang, JN
Matson, JL
Cervantes, PE
Konst, MJ
AF Jang, Jina
Matson, Johnny L.
Cervantes, Paige E.
Konst, Matthew J.
TI The relationship between ethnicity and age of first concern in toddlers
with autism spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; First concern; Ethnicity/race
ID INTENSIVE BEHAVIORAL INTERVENTION; PERVASIVE DEVELOPMENTAL DISORDER;
YOUNG-CHILDREN; FOLLOW-UP; PDD-NOS; DIAGNOSIS; INFANTS; RECOGNITION;
ASD; DISABILITIES
AB The current study examined the relationship between ethnicity and the age at which parents first become concerned about their children's development in 1478 toddlers with autism spectrum disorder (ASD) and atypical development. Based on the current findings, there were no racial/ethnic differences in age of parent's first concerns. Caregivers of toddlers with ASD first developed concerns around the same time independent of which ethnic groups they belong to. In addition, the age of caregivers' first concerns was significantly younger for those with ASD compared to those who are atypically developing without an ASD diagnosis. Implications regarding these findings are discussed. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Jang, Jina; Matson, Johnny L.; Cervantes, Paige E.; Konst, Matthew J.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Jang, JN (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM jinajang87@gmail.com
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baghdadli A, 2003, EUR CHILD ADOLES PSY, V12, P122, DOI 10.1007/s00787-003-0314-6
Centers for Disease Control and Prevention, 2007, PREV AUT SPECTR DIS
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Chawarska K, 2007, J AUTISM DEV DISORD, V37, P62, DOI 10.1007/s10803-006-0330-8
Dawson G., 2010, PEDIATRICS, V125, P17
De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
Eikeseth S, 2012, RES AUTISM SPECT DIS, V6, P829, DOI 10.1016/j.rasd.2011.09.002
Eikeseth S, 2007, BEHAV MODIF, V31, P264, DOI 10.1177/0145445506291396
Fava L, 2011, RES AUTISM SPECT DIS, V5, P1479, DOI 10.1016/j.rasd.2011.02.009
Feinberg E, 2011, J DEV BEHAV PEDIATR, V32, P284, DOI 10.1097/DBP.0b013e3182142fbd
FENSKE EC, 1985, ANAL INTERVEN DEVEL, V5, P49, DOI 10.1016/S0270-4684(85)80005-7
Fernell E, 2010, RES DEV DISABIL, V31, P680, DOI 10.1016/j.ridd.2010.01.007
Fernell E, 2011, RES DEV DISABIL, V32, P2092, DOI 10.1016/j.ridd.2011.08.002
Fodstad JC, 2009, DEV NEUROREHABIL, V12, P152, DOI 10.1080/17518420902936748
Giannoni PP, 2010, RES DEV DISABIL, V31, P848, DOI 10.1016/j.ridd.2010.02.014
Granpeesheh D, 2009, RES AUTISM SPECT DIS, V3, P1014, DOI 10.1016/j.rasd.2009.06.007
Granpeesheh D, 2009, ANN CLIN PSYCHIATRY, V21, P162
Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
Horovitz M, 2012, RES AUTISM SPECT DIS, V6, P466, DOI 10.1016/j.rasd.2011.06.017
Horovitz M, 2010, DEV NEUROREHABIL, V13, P390, DOI 10.3109/17518423.2010.501431
Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
Inglese Melissa Dodd, 2009, J Pediatr Nurs, V24, P41, DOI 10.1016/j.pedn.2007.12.006
Kozlowski AM, 2012, RES AUTISM SPECT DIS, V6, P385, DOI 10.1016/j.rasd.2011.06.012
Kozlowski AM, 2011, DEV NEUROREHABIL, V14, P72, DOI 10.3109/17518423.2010.539193
Krakowiak P, 2012, J SLEEP RES, V21, P231, DOI 10.1111/j.1365-2869.2012.01012.x
LoVullo SV, 2009, RES DEV DISABIL, V30, P1288, DOI 10.1016/j.ridd.2009.05.004
Magana S, 2012, INTELLECT DEV DISAB, V50, P287, DOI 10.1352/1934-9556-50.4.287
Makrygianni MK, 2010, RES AUTISM SPECT DIS, V4, P577, DOI 10.1016/j.rasd.2010.01.014
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
Matson J. L., 2008, J INTELLECT DEV DIS, V33, P313
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P1319, DOI 10.1016/j.rasd.2011.03.006
Matson JL, 2010, RES AUTISM SPECT DIS, V4, P633, DOI 10.1016/j.rasd.2009.12.007
Matson JL, 2009, RES AUTISM SPECT DIS, V3, P252, DOI 10.1016/j.rasd.2008.06.005
Matson JL, 2009, RES DEV DISABIL, V30, P1317, DOI 10.1016/j.ridd.2009.05.008
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P75, DOI 10.1016/j.rasd.2007.03.002
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P60, DOI 10.1016/j.rasd.2007.03.003
Matson JL, 2003, J DEV PHYS DISABIL, V15, P57, DOI 10.1023/A:1021404304361
Matson JL, 2012, RES AUTISM SPECT DIS, V6, P271, DOI 10.1016/j.rasd.2011.05.008
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
Matson JL, 2012, RES AUTISM SPECT DIS, V6, P1412, DOI 10.1016/j.rasd.2012.02.010
Matson JL, 2009, RES AUTISM SPECT DIS, V3, P196, DOI 10.1016/j.rasd.2008.05.005
Matson JL, 2009, RES DEV DISABIL, V30, P249, DOI 10.1016/j.ridd.2008.04.002
Matson JL, 2010, DEV NEUROREHABIL, V13, P72, DOI 10.3109/17518420903213576
Matson JL, 2010, RES AUTISM SPECT DIS, V4, P300, DOI 10.1016/j.rasd.2009.10.001
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P696, DOI 10.1016/j.rasd.2008.02.003
Matson JL, 2012, DEV NEUROREHABIL, V15, P185, DOI 10.3109/17518423.2012.672341
Matson JL, 2009, RES DEV DISABIL, V30, P1203, DOI 10.1016/j.ridd.2009.04.001
Newborg J., 2007, J PSYCHOEDUCATIONAL, V25, P409, DOI DOI 10.1177/0734282907300382
Newborg J, 2005, BATTELLE DEV INVENTO
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Peters-Scheffer N, 2012, RES DEV DISABIL, V33, P1763, DOI 10.1016/j.ridd.2012.04.006
Poon KK, 2012, RES DEV DISABIL, V33, P578, DOI 10.1016/j.ridd.2011.10.025
Rivet TT, 2011, RES AUTISM SPECT DIS, V5, P957, DOI 10.1016/j.rasd.2010.12.003
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Schieve L. A., 2006, Morbidity and Mortality Weekly Report, V55, P481
Smith KRM, 2010, RES DEV DISABIL, V31, P743, DOI 10.1016/j.ridd.2010.01.016
Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
NR 65
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL
PY 2014
VL 8
IS 7
BP 925
EP 932
DI 10.1016/j.rasd.2014.04.003
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AI8UX
UT WOS:000337203600018
ER
PT J
AU Klein, BY
Tamir, H
Hirschberg, DL
Glickstein, SB
Ludwig, RJ
Welch, MG
AF Klein, Benjamin Y.
Tamir, Hadassah
Hirschberg, David L.
Glickstein, Sara B.
Ludwig, Robert J.
Welch, Martha G.
TI Oxytocin modulates markers of the unfolded protein response in Caco2BB
gut cells
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Autism spectrum disorder; Inflammatory bowel disease (IBD); Crohn's
disease; Ulcerative colitis; Signaling; Translation factors; X-box
protein 1; Simon
ID ENDOPLASMIC-RETICULUM STRESS; INITIATION-FACTOR EIF2-ALPHA;
INFLAMMATORY-BOWEL-DISEASE; ER STRESS; TRANSLATIONAL CONTROL; MAMMALIAN
TARGET; MESSENGER-RNA; INTESTINAL EPITHELIUM; TRANSCRIPTION FACTOR;
AUTISTIC DISORDER
AB We have shown that oxytocin receptor (OTR) expression in neonatal rat enterocytes is robust from birth to weaning, but OTR function during this period is unknown. We previously reported that oxytocin (OT) stimulation of Caco2BB cells (enterocytes in vitro) inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling. The unfolded protein response (UPR) is known to protectively reduce translation during endoplasmic reticulum (ER) stress. Because the mTORC1 pathway is linked to cellular stress, we investigated markers of UPR in OT-stimulated Caco2BB cells. We report that OT modulates several factors involved in sensing and translation of ER stress. High OT (62.5 nM) reduced translation initiation factor 4E-BP1 phosphorylation (Ser65), which is known to inhibit cap-dependent translation via its rate-limiting eukaryotic translation initiation factor 4E (eIF4E). Importantly, high OT increased phosphorylation of eukaryotic translation initiation factor 2a (eIF2a) phospho-Ser51, which inhibits eIF2a. High OT also increased protein kinase RNA-like endoplasmic reticulum kinase phosphorylation, a sensor of ER stress and a kinase of eIF2a. Both high and low OT activated inositol requiring enzyme1 (IRE1), which generates the transcription factor X-box binding protein 1 (XBP1) and induces the UPR. We also show that OT modulates XBP1 splicing and induces tribbles 3 (TRIB3; a negative regulator of Akt and protein involved in autophagy) and immunoglobulin binding protein (BiP; ER-chaperone). Taken together, these results indicate that OT modulates sensors of ER stress and autophagy. These findings support our hypothesis that transiently elevated OTR expression in neonatal gut may serve a protective function during a critical postnatal developmental period.
C1 [Klein, Benjamin Y.; Ludwig, Robert J.; Welch, Martha G.] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA.
[Tamir, Hadassah; Hirschberg, David L.; Welch, Martha G.] Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA.
[Hirschberg, David L.] Columbia Univ Coll Phys & Surg, Ctr Infect & Immunol, New York, NY 10032 USA.
[Tamir, Hadassah] New York State Psychiat Inst & Hosp, Div Mol Imaging & Neuropathol, New York, NY 10032 USA.
[Glickstein, Sara B.] EB Sci, Oakland, CA 94611 USA.
[Klein, Benjamin Y.; Welch, Martha G.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
RP Klein, BY (reprint author), New York State Psychiat Inst & Hosp, 1051 Riverside Dr,Unit 40, New York, NY 10032 USA.
EM bk2348@columbia.edu; mgw13@columbia.edu
FU Einhorn Family Charitable Trust [UL1 RR024156]
FX We thank Chris Heger for Simon (TM) automated western blotting
consultation and analysis, as well as with help in manuscript
preparation. We thank Maurice Manning for supplying the oxytocin
antagonist. The research was funded by the Einhorn Family Charitable
Trust (UL1 RR024156).
CR Amico JA, 2004, J NEUROENDOCRINOL, V16, P319, DOI 10.1111/j.0953-8194.2004.01161.x
B'Chir W, 2013, NUCL ACIDS RES
Bartz JA, 2008, PROG BRAIN RES, V170, P451, DOI 10.1016/S0079-6123(08)00435-4
Bernales S, 2006, ANNU REV CELL DEV BI, V22, P487, DOI 10.1146/annurev.cellbio.21.122303.120200
Bertolotti A, 2000, NAT CELL BIOL, V2, P326
Brunton PJ, 2008, PROG BRAIN RES, V170, P365, DOI 10.1016/S0079-6123(08)00430-5
Calfon M, 2002, NATURE, V415, P92, DOI 10.1038/415092a
Cetinel S, 2010, REGUL PEPTIDES, V160, P146, DOI 10.1016/j.regpep.2009.11.011
Corradetti MN, 2006, ONCOGENE, V25, P6347, DOI 10.1038/sj.onc.1209885
Costa-Mattioli M, 2009, PROG MOL BIOL TRANSL, V90, P293, DOI 10.1016/S1877-1173(09)90008-4
Du KY, 2003, SCIENCE, V300, P1574, DOI 10.1126/science.1079817
Dunlop EA, 2009, CELL SIGNAL, V21, P827, DOI 10.1016/j.cellsig.2009.01.012
Dunlop EA, 2011, AUTOPHAGY, V7, P737, DOI 10.4161/auto.7.7.15491
Foster KG, 2010, J BIOL CHEM, V285, P14071, DOI 10.1074/jbc.R109.094003
Gingras AC, 1999, GENE DEV, V13, P1422, DOI 10.1101/gad.13.11.1422
Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
Gonzalez R, 2002, J THEOR BIOL, V214, P529, DOI 10.1006/jtbi.2001.2478
Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
Hetz C, 2009, MOL CELL, V35, P551, DOI 10.1016/j.molcel.2009.08.021
Hetz C, 2011, PHYSIOL REV, V91, P1219, DOI 10.1152/physrev.00001.2011
Hodin CM, 2011, J PATHOL, V225, P276, DOI 10.1002/path.2917
Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1
Horvath Karoly, 2002, Curr Gastroenterol Rep, V4, P251, DOI 10.1007/s11894-002-0071-6
Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
Kang DW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068322
Kaser A, 2008, CELL, V134, P743, DOI 10.1016/j.cell.2008.07.021
Kaser A, 2010, CURR OPIN GASTROEN, V26, P318, DOI 10.1097/MOG.0b013e32833a9ff1
Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
Kimball SR, 1998, J BIOL CHEM, V273, P12841, DOI 10.1074/jbc.273.21.12841
Klein BY, 2013, BIOCH BIOPHYSICAL RE
Klein BY, 2011, J CELL BIOCHEM, V112, P3216, DOI 10.1002/jcb.23243
Koumenis C, 2002, MOL CELL BIOL, V22, P7405, DOI 10.1128/MCB.22.21.7405-7416.2002
Lee AH, 2003, MOL CELL BIOL, V23, P7448, DOI 10.1128/MCB.23.21.7448-7459.2003
Ma XJM, 2009, NAT REV MOL CELL BIO, V10, P307, DOI 10.1038/nrm2672
Ma YJ, 2003, J BIOL CHEM, V278, P34864, DOI 10.1074/jbc.M301107200
MANNING M, 1995, INT J PEPT PROT RES, V46, P244
Margolis KG, 2013, DIG DIS WEEK ORL FL
Martinon F, 2011, CURR OPIN IMMUNOL, V23, P35, DOI 10.1016/j.coi.2010.10.016
Martinon F, 2010, NAT IMMUNOL, V11, P411, DOI 10.1038/ni.1857
Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
Noiseux N, 2012, ENDOCRINOLOGY, V153, P5361, DOI 10.1210/en.2012-1402
Ohoka N, 2005, EMBO J, V24, P1243, DOI 10.1038/sj.emboj.7600596
Onaka T, 2012, J NEUROENDOCRINOL, V24, P587, DOI 10.1111/j.1365-2826.2012.02300.x
Pinto D, 2005, EXP CELL RES, V306, P357, DOI 10.1016/j.yexcr.2005.02.022
Rong L, 2008, RNA, V14, P1318, DOI 10.1261/rna.950608
Sato Y, 2011, CELL STRUCT FUNCT, V36, P35, DOI 10.1247/csf.10010
Song JQ, 2009, MOL MED, V15, P316, DOI 10.2119/molmed.2009.00048
TAKEDA S, 1986, ENDOCRINOL JAPON, V33, P821
Todd DJ, 2009, J EXP MED, V206, P2151, DOI 10.1084/jem.20090738
Tu BP, 2000, SCIENCE, V290, P1571, DOI 10.1126/science.290.5496.1571
Wang HS, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00028
Welch MG, 2010, NEUROGASTROENT MOTIL, V22, P654, DOI 10.1111/j.1365-2982.2010.01477.x
Welch MG, 2009, J COMP NEUROL, V512, P256, DOI 10.1002/cne.21872
Yoshida H, 2006, J CELL BIOL, V172, P565, DOI 10.1083/jcb.200508145
Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
Zhang KZ, 2004, J BIOL CHEM, V279, P25935, DOI 10.1074/jbc.R400008200
NR 56
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD JUL
PY 2014
VL 19
IS 4
BP 465
EP 477
DI 10.1007/s12192-013-0473-4
PG 13
WC Cell Biology
SC Cell Biology
GA AI6IK
UT WOS:000336976100002
PM 24198165
ER
PT J
AU Modi, ME
Connor-Stroud, F
Landgraf, R
Young, LJ
Parr, LA
AF Modi, Meera E.
Connor-Stroud, Fawn
Landgraf, Rainer
Young, Larry J.
Parr, Lisa A.
TI Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus
macaques
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Oxytocin; Vasopressin; Social cognition; Intranasal; Autism; Rhesus
monkey
ID AUTISM SPECTRUM DISORDERS; INTRANASAL OXYTOCIN; VASOPRESSIN RELEASE;
PLASMA OXYTOCIN; SOCIAL-BEHAVIOR; BRAIN; NASAL; BLOOD; NEUROPEPTIDES;
INTRANUCLEAR
AB Intranasal (IN) administration is a widely used method for examining the effect of oxytocin (OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT in humans enhances trust, emotional perception, and empathetic behavior and is under investigation as a potential pharmacotherapy to enhance social functioning in a variety of neuropsychiatric disorders, including autism spectrum disorders (ASD). Nonhuman primates (NHP) are an important model for understanding the effect of OT on social cognition, its neural mechanisms, and the development of IN-OT as a pharmacotherapy for treating social deficits in humans. However, NHP and even some human populations, such as very young infants and children, cannot easily follow the detailed self-administration protocol used in the majority of human IN-OTstudies. Therefore, we evaluated the efficacy of several OT-administration routes for elevating central OT concentrations in rhesus macaques. First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF. Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route. All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT. No route affected concentrations of AVP in plasma or CSF. This study confirms that the AE route is the most effective method for increasing central OT concentrations in monkeys, and may also be an effective route, alternative to IN, for administering OT to some human populations. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Modi, Meera E.; Young, Larry J.; Parr, Lisa A.] Emory Univ, Silvio O Conte Ctr Oxytocin & Social Cognit, Ctr Translat Social Neurosci, Dept Psychiat & Behav Sci, Atlanta, GA USA.
[Modi, Meera E.; Connor-Stroud, Fawn; Young, Larry J.; Parr, Lisa A.] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA USA.
[Landgraf, Rainer] Max Planck Inst Psychiat, D-80804 Munich, Germany.
RP Modi, ME (reprint author), 610 Main St, Cambridge, MA 02139 USA.
EM meera.modi@pfizer.com
FU NSF Center for Behavioral Neuroscience Pilot Grant (LAP); Emory
Neuroscience Initiative Seed Grant; Center for Translational Social
Neuroscience Pilot Grant; NIH [MH068791, MH064692, P50MH100023];
National Center for Research Resources YNPRC [P51RR165]; Office of
Research Infrastructure Programs/OD [P510D11132]
FX The authors would like to thank the YNPRC veterinary staff for their
vital participation in the collection of samples and Dr. Mar Sanchez for
her advice and assistance. We would also like to acknowledge funding
support from NSF Center for Behavioral Neuroscience Pilot Grant (LAP),
Emory Neuroscience Initiative Seed Grant (MEM, LJY, LAP), Center for
Translational Social Neuroscience Pilot Grant (LAP, LJY), NIH MH068791
(LAP) and MH064692 (LJY), P50MH100023 (LJY and LAP) and National Center
for Research Resources P51RR165 to YNPRC, which is currently supported
by the Office of Research Infrastructure Programs/OD P510D11132.
CR ALTNER H, 1974, CELL TISSUE RES, V154, P51
Anagnostou E, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-16
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Bartz JA, 2008, PROG BRAIN RES, V170, P451, DOI 10.1016/S0079-6123(08)00435-4
Born J, 2002, NAT NEUROSCI, V5, P514, DOI 10.1038/nn849
Burri A, 2008, PSYCHONEUROENDOCRINO, V33, P591, DOI 10.1016/j.psyneuen.2008.01.014
Chang SWC, 2012, P NATL ACAD SCI USA, V109, P959, DOI 10.1073/pnas.1114621109
Churchland PS, 2012, HORM BEHAV, V61, P392, DOI 10.1016/j.yhbeh.2011.12.003
Dhuria SV, 2009, J PHARM SCI-US, V98, P2501, DOI 10.1002/jps.21604
Domes G, 2010, PSYCHONEUROENDOCRINO, V35, P83, DOI 10.1016/j.psyneuen.2009.06.016
Donaldson ZR, 2008, SCIENCE, V322, P900, DOI 10.1126/science.1158668
Ebitz RB, 2013, P NATL ACAD SCI USA, V110, P11630, DOI 10.1073/pnas.1305230110
ERMISCH A, 1985, ENDOCRINOL EXP, V19, P29
Frank D. O., 2011, OTOLARYNGOL HEAD NEC, V146, P313
Freeman S. M., 2014, PSYCHONEURO IN PRESS
FreundMercier MJ, 1995, ADV EXP MED BIOL, V395, P185
Guastella Adam J, 2012, Horm Behav, V61, P410, DOI 10.1016/j.yhbeh.2012.01.002
Guastella AJ, 2008, BIOL PSYCHIAT, V63, P3, DOI 10.1016/j.biopsych.2007.06.026
Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
Guastella AJ, 2013, PSYCHONEUROENDOCRINO, V38, P612, DOI 10.1016/j.psyneuen.2012.11.019
HARKEMA JR, 1990, ENVIRON HEALTH PERSP, V85, P231, DOI 10.2307/3430686
Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
Klein JT, 2009, CURR BIOL, V19, pR958, DOI 10.1016/j.cub.2009.08.010
Kosfeld M, 2005, NATURE, V435, P673, DOI 10.1038/nature03701
Landgraf R, 2004, FRONT NEUROENDOCRIN, V25, P150, DOI 10.1016/j.yfrne.2004.05.001
LANDGRAF R, 1985, EXP CLIN ENDOCRINOL, V85, P245
Landis Margaret S, 2012, Ther Deliv, V3, P195
Lochhead J. J., 2011, ADV DRUG DELIV REV, V64, P614, DOI DOI 10.1016/J.ADDR.2011.11.002
MENS WBJ, 1983, BRAIN RES, V262, P143, DOI 10.1016/0006-8993(83)90478-X
Modi ME, 2012, HORM BEHAV, V61, P340, DOI 10.1016/j.yhbeh.2011.12.010
NEUMANN I, 1994, ENDOCRINOLOGY, V134, P141, DOI 10.1210/en.134.1.141
NEUMANN I, 1993, NEUROENDOCRINOLOGY, V58, P637, DOI 10.1159/000126604
Neumann ID, 2006, AM J PHYSIOL-REG I, V291, pR29, DOI 10.1152/ajpregu.00763.2005
Neumann ID, 2013, PSYCHONEUROENDOCRINO, V38, P1985, DOI 10.1016/j.psyneuen.2013.03.003
Neumann ID, 2012, TRENDS NEUROSCI, V35, P649, DOI 10.1016/j.tins.2012.08.004
Parr LA, 2013, PSYCHONEUROENDOCRINO, V38, P1748, DOI 10.1016/j.psyneuen.2013.02.011
Rimmele U, 2009, J NEUROSCI, V29, P38, DOI 10.1523/JNEUROSCI.4260-08.2009
Ross HE, 2009, FRONT NEUROENDOCRIN, V30, P534, DOI 10.1016/j.yfrne.2009.05.004
Savaskan E, 2008, PSYCHONEUROENDOCRINO, V33, P368, DOI 10.1016/j.psyneuen.2007.12.004
Striepens N, 2013, SCI REP-UK, V3, DOI 10.1038/srep03440
Suman JD, 1999, PHARMACEUT RES, V16, P1648, DOI 10.1023/A:1011933410898
Tachibana M, 2013, J CHILD ADOL PSYCHOP, V23, P123, DOI 10.1089/cap.2012.0048
Young LJ, 2012, HORM BEHAV, V61, P227, DOI 10.1016/j.yhbeh.2012.02.019
NR 44
TC 5
Z9 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2014
VL 45
BP 49
EP 57
DI 10.1016/j.psyneuen.2014.02.011
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AI8WY
UT WOS:000337208900006
PM 24845176
ER
PT J
AU Freeman, SM
Inoue, K
Smith, AL
Goodman, MM
Young, LJ
AF Freeman, Sara M.
Inoue, Kiyoshi
Smith, Aaron L.
Goodman, Mark M.
Young, Larry J.
TI The neuroanatomical distribution of oxytocin receptor binding and mRNA
in the male rhesus macaque (Macaca mulatta)
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Oxytocin receptor; Neuropeptide; Neuroanatomy; Nonhuman primate; Autism
ID PEDUNCULOPONTINE TEGMENTAL NUCLEUS; GUIDED SACCADE TASKS; SUPERIOR
COLLICULUS; SOCIAL-BEHAVIOR; MICROTUS-OCHROGASTER; INTRANASAL OXYTOCIN;
PRIMATE BRAIN; VASOPRESSIN; NEURONS; EXPRESSION
AB The rhesus macaque (Macaca mulatta) is an important primate model for social cognition, and recent studies have begun to explore the impact of oxytocin on social cognition and behavior. Macaques have great potential for elucidating the neural mechanisms by which oxytocin modulates social cognition, which has implications for oxytocin-based pharmacotherapies for psychiatric disorders such as autism and schizophrenia. Previous attempts to localize oxytocin receptors (OXTR) in the rhesus macaque brain have failed due to reduced selectivity of radioligands, which in primates bind to both OXTR and the structurally similar vasopressin la receptor (AVPR1A). We have developed a pharmacologically-informed competitive binding autoradiography protocol that selectively reveals OXTR and AVPR1A binding sites in primate brain sections. Using this protocol, we describe the neuroanatomical distribution of OXTR in the macaque. Finally, we use in situ hybridization to localize OXTR mRNA. Our results demonstrate that OXTR expression in the macaque brain is much more restricted than AVPR1A. OXTR is largely limited to the nucleus basalis of Meynert, pedunculopontine tegmental nucleus, the superficial gray layer of the superior colliculus, the trapezoid body, and the ventromedial hypothalamus. These regions are involved in a variety of functions relevant to social cognition, including modulating visual attention, processing auditory and multimodal sensory stimuli, and controlling orienting responses to visual stimuli. These results provide insights into the neural mechanisms by which oxytocin modulates social cognition and behavior in this species, which, like humans, uses vision and audition as the primary modalities for social communication. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Freeman, Sara M.; Inoue, Kiyoshi; Smith, Aaron L.; Young, Larry J.] Emory Univ, Yerkes Natl Primate Res Ctr, Silvio O Conte Ctr Oxytocin & Social Cognit, Dept Psychiat & Behav Sci,Ctr Translat Social Neu, Atlanta, GA 30029 USA.
[Smith, Aaron L.; Goodman, Mark M.] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30029 USA.
RP Freeman, SM (reprint author), Univ Calif Davis, Calif Natl Primate Res Ctr BMB, One Shields Ave, Davis, CA 95616 USA.
EM smfreem@ucdavis.edu
FU NIH grants [MH090776, 1P50MH100023]; Office of Research Infrastructure
Programs/OD [P510D011132, P51RR000165]; [T32MH073525-06]
FX This work was supported by NIH grants MH090776 and 1P50MH100023 to
L.J.Y. Training support for S.M.F was provided by T32MH073525-06.
Additional support was provided by Office of Research Infrastructure
Programs/OD P510D011132 (formerly NCRR P51RR000165) to YNPRC.
CR Acher R, 1995, ADV EXP MED BIOL, V395, P615
Ala Y, 1997, EUR J PHARMACOL, V331, P285, DOI 10.1016/S0014-2999(97)01021-2
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Bakermans-Kranenburg MJ, 2012, SOC COGN AFFECT NEUR, V7, P951, DOI 10.1093/scan/nsr067
Bale TL, 2001, J NEUROSCI, V21, P2546
Beery AK, 2008, J COMP NEUROL, V507, P1847, DOI 10.1002/cne.21638
Boccia ML, 2013, NEUROSCIENCE, V253, P155, DOI 10.1016/j.neuroscience.2013.08.048
Boccia ML, 2001, NEUROREPORT, V12, P1723, DOI 10.1097/00001756-200106130-00041
Borst JGG, 2012, ANNU REV PHYSIOL, V74, P199, DOI 10.1146/annurev-physiol-020911-153236
Burbach JPH, 2006, KNOBIL AND NEILL'S PHYSIOLOGY OF REPRODUCTION, VOLS 1 AND 2, 3RD EDITON, P3055
Chang SWC, 2012, P NATL ACAD SCI USA, V109, P959, DOI 10.1073/pnas.1114621109
Dolen G, 2013, NATURE, V501, P179, DOI 10.1038/nature12518
Domes G, 2013, BIOL PSYCHIAT, V74, P164, DOI 10.1016/j.biopsych.2013.02.007
Ebitz RB, 2013, P NATL ACAD SCI USA, V110, P11630, DOI 10.1073/pnas.1305230110
Ferguson JN, 2001, J NEUROSCI, V21, P8278
Freeman SM, 2013, OXYTOCIN, VASOPRESSIN AND RELATED PEPTIDES IN THE REGULATION OF BEHAVIOR, P128
Fritz JB, 2007, CURR OPIN NEUROBIOL, V17, P437, DOI 10.1016/j.conb.2007.07.011
Gal C.S.-L., 1993, J CLIN INVEST
Gamer M, 2010, P NATL ACAD SCI USA, V107, P9400, DOI 10.1073/pnas.1000985107
Garrison JL, 2012, SCIENCE, V338, P540, DOI 10.1126/science.1226201
GOLDBERG ME, 1972, J NEUROPHYSIOL, V35, P542
Gothard KM, 2007, J NEUROPHYSIOL, V97, P1671, DOI 10.1152/jn.00714.2006
Gruber CW, 2010, CURR PHARM DESIGN, V16, P3071
Guastella Adam J, 2012, Horm Behav, V61, P410, DOI 10.1016/j.yhbeh.2012.01.002
Hawley ML, 2004, J ACOUST SOC AM, V115, P833, DOI 10.1121/1.1639908
Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
Inoue K, 2013, NEUROSCIENCE, V244, P122, DOI 10.1016/j.neuroscience.2013.03.035
Kobayashi Y, 2002, J NEUROPHYSIOL, V88, P715, DOI 10.1152/jn.00484.2001
Kobayashi Y, 2001, BRAIN DEV-JPN, V23, pS24, DOI 10.1016/S0387-7604(01)00330-8
Leng G, 2008, PROG BRAIN RES, V170, P137, DOI 10.1016/S0079-6123(08)00413-5
Lim MM, 2004, NATURE, V429, P754, DOI 10.1038/nature02539
Lim MM, 2004, J COMP NEUROL, V468, P555, DOI 10.1002/cne.10973
LOUP F, 1991, BRAIN RES, V555, P220, DOI 10.1016/0006-8993(91)90345-V
MA TP, 1991, EXP BRAIN RES, V85, P21
Manning M, 2012, J NEUROENDOCRINOL, V24, P609, DOI 10.1111/j.1365-2826.2012.02303.x
MCCARTHY MM, 1994, NEUROENDOCRINOLOGY, V59, P432, DOI 10.1159/000126689
Modi ME, 2012, HORM BEHAV, V61, P340, DOI 10.1016/j.yhbeh.2011.12.010
Modi M.E., 2014, PSYCHONEUROENDOCRINO
MUIR JL, 1993, BEHAV BRAIN RES, V57, P123, DOI 10.1016/0166-4328(93)90128-D
Okada KI, 2009, EUR J NEUROSCI, V30, P2211, DOI 10.1111/j.1460-9568.2009.07009.x
Olazabal DE, 2006, HORM BEHAV, V49, P681, DOI 10.1016/j.yhbeh.2005.12.010
Owen SF, 2013, NATURE, V500, P458, DOI 10.1038/nature12330
Parr L.A., 2013, PSYCHONEUROENDOCRINO
Paxinos G, 1999, RHESUS MONKEY BRAIN
Riem MME, 2012, NEUROPSYCHOPHARMACOL, V37, P1257, DOI 10.1038/npp.2011.313
Salvatore CA, 1998, J RECEPT SIGNAL TR R, V18, P15, DOI 10.3109/10799899809039162
Scheele D, 2013, P NATL ACAD SCI USA, V110, P20308, DOI 10.1073/pnas.1314190110
Scheele D, 2012, J NEUROSCI, V32, P16074, DOI 10.1523/JNEUROSCI.2755-12.2012
Schneggenburger R, 2006, CELL TISSUE RES, V326, P311, DOI 10.1007/s00441-006-0272-7
Schorscher-Petcu A, 2009, NEUROSCI LETT, V461, P217, DOI 10.1016/j.neulet.2009.06.016
Schorscher-Petcu A, 2010, J NEUROSCI, V30, P8274, DOI 10.1523/JNEUROSCI.1594-10.2010
Skuse D.H., 2013, P NATL ACAD SCI
Smith AL, 2013, BIOORG MED CHEM LETT, V23, P5415, DOI 10.1016/j.bmcl.2013.07.045
Smith AS, 2010, HORM BEHAV, V57, P255, DOI 10.1016/j.yhbeh.2009.12.004
Snowdon CT, 2010, HORM BEHAV, V58, P614, DOI 10.1016/j.yhbeh.2010.06.014
Song E.Z., 2013, SOC NEUR ANN M SAN D
Terenzi MG, 2005, NEUROSCIENCE, V134, P345, DOI 10.1016/j.neuroscience.2005.04.004
Toloczko DM, 1997, ANN NY ACAD SCI, V807, P506, DOI 10.1111/j.1749-6632.1997.tb51953.x
Tops Mattie, 2011, Front Psychiatry, V2, P60, DOI 10.3389/fpsyt.2011.00060
Wagenaar DA, 2010, CURR BIOL, V20, P487, DOI 10.1016/j.cub.2010.02.027
Walum H, 2012, BIOL PSYCHIAT, V71, P419, DOI 10.1016/j.biopsych.2011.09.002
Wilson BC, 2005, NEUROPEPTIDES, V39, P403, DOI 10.1016/j.npep.2005.04.001
Winn P, 2006, J NEUROL SCI, V248, P234, DOI 10.1016/j.jns.2006.05.036
WURTZ RH, 1972, INVEST OPHTH VISUAL, V11, P441
Yoshida M, 2009, J NEUROSCI, V29, P2259, DOI 10.1523/JNEUROSCI.5593-08.2009
Young LJ, 2012, HORM BEHAV, V61, P227, DOI 10.1016/j.yhbeh.2012.02.019
Young LJ, 2004, NAT NEUROSCI, V7, P1048, DOI 10.1038/nn1327
Young LJ, 1999, J NEUROENDOCRINOL, V11, P291
Zehr JL, 1998, HORM BEHAV, V33, P95, DOI 10.1006/hbeh.1998.1440
Zink CF, 2012, HORM BEHAV, V61, P400, DOI 10.1016/j.yhbeh.2012.01.016
NR 70
TC 9
Z9 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2014
VL 45
BP 128
EP 141
DI 10.1016/j.psyneuen.2014.03.023
PG 14
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AI8WY
UT WOS:000337208900014
PM 24845184
ER
PT J
AU Renoux, AJ
Sala-Hamrick, KJ
Carducci, NM
Frazer, M
Halsey, KE
Sutton, MA
Dolan, DF
Murphy, GG
Todd, PK
AF Renoux, A. J.
Sala-Hamrick, K. J.
Carducci, N. M.
Frazer, M.
Halsey, K. E.
Sutton, M. A.
Dolan, D. F.
Murphy, G. G.
Todd, P. K.
TI Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation
model mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Fragile X; Premutation carrier; Prepulse inhibition; Sensorimotor gating
ID PREPULSE INHIBITION; STARTLE RESPONSE; HEARING-LOSS;
BEHAVIORAL-PHENOTYPE; MENTAL-RETARDATION; C57BL/6J MICE; MOUSE MODEL;
AUTISM; ABNORMALITIES; PLASTICITY
AB Fragile X syndrome (FXS) is a common inherited cause of intellectual disability that results from a CGG repeat expansion in the FMR1 gene. Large repeat expansions trigger both transcriptional and translational suppression of Fragile X protein (FMRP) production. Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is an allelic neurodegenerative disease caused by smaller "pre-mutation" CGG repeat expansions that enhance FMR1 transcription but lead to translational inefficiency and reduced FMRP expression in animal models. Sensorimotor gating as measured by pre-pulse inhibition (PPI) is altered in both FXS patients and Fmr1 knock out (KO) mice. Similarly, FXTAS patients have demonstrated PPI deficits. Recent work suggests there may be overlapping synaptic defects between Fmr1 KO and CGG knock-in premutation mouse models (CGG KI). We therefore sought to interrogate PPI in CGG 10 mice. Using a quiet PPI protocol more akin to human testing conditions, we find that Fmr1 KO animals have significantly impaired PPI. Using this same protocol, we find CGG KI mice demonstrate an age-dependent impairment in PPI compared to wild type (WT) controls. This study describes a novel phenotype in CGG KI mice that can be used in future therapeutic development targeting premutation associated symptoms. Published by Elsevier B.V.
C1 [Halsey, K. E.; Dolan, D. F.] Kresge Hearing Res Inst, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI USA.
[Sutton, M. A.; Murphy, G. G.] Mol & Behav Neurosci Inst, Ann Arbor, MI USA.
RP Todd, PK (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA.
EM petertod@umich.edu
FU National Institutes of Mental Health [F31MH097451]; National Fragile X
Foundation
FX We thank Peter Ghisleni for technical assistance. CGG KI mice were
donated by Karen Usdin (NIH). Fmr1 KO mice were obtained from Cara
Westmark (University of Wisconsin) and Jim Malter (UT Southwestern).
This work was supported by the National Institutes of Mental Health
(F31MH097451) to AJR; the National Fragile X Foundation student
fellowship to MF; core testing facilities provided by NIH (P30 DC05188)
to KEH and DFD; National Institute on Aging (R01AG028488) to GGM; and by
the Veterans Administration (BLRD #1I01BX001689) and NIH (1K08NS069809)
to PKT.
CR [Anonymous], 1994, CELL, V78, P23
Baker KB, 2010, GENES BRAIN BEHAV, V9, P562, DOI 10.1111/j.1601-183X.2010.00585.x
Chen L, 2001, NEUROSCIENCE, V103, P1043, DOI 10.1016/S0306-4522(01)00036-7
Clifford S, 2007, J AUTISM DEV DISORD, V37, P738, DOI 10.1007/s10803-006-0205-z
de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002
Dolan DF, 2012, ASS RES OT M ARO
Farzin F, 2006, J DEV BEHAV PEDIATR, V27, pS137, DOI 10.1097/00004703-200604002-00012
FENG Y, 1995, SCIENCE, V268, P731, DOI 10.1126/science.7732383
Frankland PW, 2004, MOL PSYCHIATR, V9, P417, DOI 10.1038/sj.mp.4001432
Hessl D, 2009, AM J MED GENET B, V150B, P545, DOI 10.1002/ajmg.b.30858
Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
Iliff AJ, 2013, HUM MOL GENET, V22, P1180, DOI 10.1093/hmg/dds525
Ison JR, 2007, JARO-J ASSOC RES OTO, V8, P539, DOI 10.1007/s10162-007-0098-3
Johnson KR, 1997, HEARING RES, V114, P83, DOI 10.1016/S0378-5955(97)00155-X
Karolyi IJ, 2007, MAMM GENOME, V18, P596, DOI 10.1007/s00335-007-9038-0
Ludwig AL, 2014, HUM MOL GENET
Nelson DL, 2013, NEURON, V77, P825, DOI 10.1016/j.neuron.2013.02.022
Nielsen DM, 2002, BRAIN RES, V927, P8, DOI 10.1016/S0006-8993(01)03309-1
Paylor R, 2008, BEHAV NEUROSCI, V122, P1371, DOI 10.1037/a0013047
Powell Susan B, 2012, Curr Top Behav Neurosci, V12, P251, DOI 10.1007/7854_2011_195
Pretto DI, 2014, NEUROBIOL AGING, V35, P1189, DOI 10.1016/j.neurobiolaging.2013.11.009
Qin M, 2011, NEUROBIOL DIS, V42, P85, DOI 10.1016/j.nbd.2011.01.008
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
Schneider A, 2012, NEUROBIOL AGING, V33, P1045, DOI 10.1016/j.neurobiolaging.2010.09.002
Taberner AM, 2005, J NEUROPHYSIOL, V93, P557, DOI 10.1152/jn.00574.2004
Todd PK, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001240
Veeraragavan S, 2012, BEHAV BRAIN RES, V228, P1, DOI 10.1016/j.bbr.2011.11.018
WILLOTT JF, 1994, BEHAV NEUROSCI, V108, P703, DOI 10.1037/0735-7044.108.4.703
NR 28
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 1
PY 2014
VL 267
BP 42
EP 45
DI 10.1016/j.bbr.2014.03.013
PG 4
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AI2UK
UT WOS:000336713400007
PM 24657592
ER
PT J
AU Dejanovic, BL
Lal, D
Catarino, CB
Arjune, S
Belaidi, AA
Trucks, H
Vollmar, C
Surges, R
Kunz, WS
Motameny, S
Altmuller, J
Kohler, A
Neubauer, BA
Nurnberg, P
Noachtar, S
Schwarz, G
Sander, T
AF Dejanovic, Boris Lav
Lal, Dennis
Catarino, Claudia B.
Arjune, Sita
Belaidi, Abdel A.
Trucks, Holger
Vollmar, Christian
Surges, Rainer
Kunz, Wolfram S.
Motameny, Susanne
Altmueller, Janine
Koehler, Anna
Neubauer, Bernd A.
Nuernberg, Peter
Noachtar, Soheyl
Schwarz, Gunter
Sander, Thomas
CA EPICURE Consortium
TI Exonic microdeletions of the gephyrin gene impair GABAergic synaptic
inhibition in patients with idiopathic generalized epilepsy
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE Idiopathic generalized epilepsy; Microdeletion; GPHN; Gephyrin
ID MOLYBDENUM COFACTOR DEFICIENCY; TRANSCRANIAL MAGNETIC STIMULATION;
CLUSTERING PROTEIN GEPHYRIN; MOTOR CORTEX EXCITABILITY; GABA(A) RECEPTOR
SUBTYPES; DIRECT BINDING; NEURODEVELOPMENTAL DISEASE; 16P13.11
PREDISPOSE; GAMMA-2 SUBUNIT; DOWN-REGULATION
AB Gephyrin is a postsynaptic scaffolding protein, essential for the clustering of glycine and gamma-aminobutyric acid type-A receptors (GABA(A)Rs) at inhibitory synapses. An impairment of GABAergic synaptic inhibition represents a key pathway of epileptogenesis. Recently, exonic microdeletions in the gephyrin (GPHN) gene have been associated with neurodevelopmental disorders including autism spectrum disorder, schizophrenia and epileptic seizures. Here we report the identification of novel exonic GPHN microdeletions in two patients with idiopathic generalized epilepsy (ICE), representing the most common group of genetically determined epilepsies. The identified GPHN microdeletions involve exons 5-9 (Delta 5-9) and 2-3 (Delta 2-3), both affecting the gephyrin G-domain. Molecular characterization of the GPHN Delta 5-9 variant demonstrated that it perturbs the clustering of regular gephyrin at inhibitory synapses in cultured mouse hippocampal neurons in a dominant-negative manner, resulting in a significant loss of gamma(2)-subunit containing GABAARs. GPHN Delta 2-3 causes a frameshift resulting in a premature stop codon (p.V22Gfs*7) leading to haplo-insufficiency of the gene. Our results demonstrate that structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission. (C) 2014 Published by Elsevier Inc.
C1 [Dejanovic, Boris Lav; Arjune, Sita; Belaidi, Abdel A.; Koehler, Anna; Schwarz, Gunter] Univ Cologne, Inst Biochem, Dept Chem, D-50674 Cologne, Germany.
[Lal, Dennis; Trucks, Holger; Motameny, Susanne; Altmueller, Janine; Nuernberg, Peter; Sander, Thomas] Univ Cologne, CCG, D-50931 Cologne, Germany.
[Lal, Dennis; Schwarz, Gunter] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany.
[Lal, Dennis; Neubauer, Bernd A.] Univ Med Ctr Giessen & Marburg, Dept Neuropediat, D-35392 Giessen, Germany.
[Vollmar, Christian; Noachtar, Soheyl] Univ Munich, Dept Neurol, Epilepsy Ctr, D-81377 Munich, Germany.
[Surges, Rainer; Kunz, Wolfram S.] Univ Clin Bonn, Dept Epileptol, D-53105 Bonn, Germany.
[Nuernberg, Peter; Schwarz, Gunter] Univ Cologne, Ctr Mol Med CMMC, D-50931 Cologne, Germany.
RP Schwarz, G (reprint author), Univ Cologne, Inst Biochem, Zulpicher Str 47, D-50674 Cologne, Germany.
EM gschwarz@uni-koeln.de; thomas.sander@uni-koeln.de
RI baykan, betul/J-5307-2014; Catarino, Claudia/A-7719-2010
OI Catarino, Claudia/0000-0002-6528-7570
FU European Community [LSHM-CT-2006-037315]; German Research Foundation
(DFG) [NE416/5-1, SA434/5-1, NU50/8-1]; German Federal Ministry of
Education and Research; National Genome Research Network [NGENplus:
EMINet] [01GS08120, 01GS08121, 01DL12011]; PopGenbiobank; Center for
Molecular Medicine Cologne; Fonds der Chemischen Industrie; Helmholtz
Zentrum Munchen-German Research Center for Environmental Health; State
of Bavaria; Munich Center of Health Sciences (MC Health) as part of
LMUinnovativ; [SFB635]
FX This work was supported by grants from the European Community [FP6
Integrated Project EPICURE, grant LSHM-CT-2006-037315 to T.S.], the
German Research Foundation (DFG) within the EUROCORES Programme
EuroEPINOMICS [grants NE416/5-1 to B.N., SA434/5-1 to T.S., NU50/8-1 to
P.N.], the SFB635 [grant All to G.S.]; the German Federal Ministry of
Education and Research, National Genome Research Network [NGENplus:
EMINet, grants 01GS08120 to T.S., and 01GS08121 to P.N.; IntenC, grant
01DL12011 to T.S.]: the PopGen biobank [grant to A.F.],the Center for
Molecular Medicine Cologne [to G.S.] and the Fonds der Chemischen
Industrie [to G.S.]. The PopGen project received infrastructure support
through the German Research Foundation excellence cluster "Inflammation
at Interfaces". The KORA research platform (KORA, Cooperative Research
in the Region of Augsburg) was initiated and financed by the Helmholtz
Zentrum Munchen-German Research Center for Environmental Health, which
is funded by the German Federal Ministry of Education and Research and
by the State of Bavaria; this research was supported within the Munich
Center of Health Sciences (MC Health) as part of LMUinnovativ.
CR Alldred MJ, 2005, J NEUROSCI, V25, P594, DOI 10.1523/JNEUROSCI.4011-04.2005
Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
BAMFORTH FJ, 1990, CLIN BIOCHEM, V23, P537, DOI 10.1016/0009-9120(90)80046-L
Belaidi AA, 2013, BIOCHEM J, V450, P149, DOI 10.1042/BJ20121078
Chang YF, 2007, ANNU REV BIOCHEM, V76, P51, DOI 10.1146/annurev.biochem.76.050106.093909
Coe BP, 2012, CURR OPIN NEUROBIOL, V22, P829, DOI 10.1016/j.conb.2012.04.007
Coe BP, 2012, AM J MED GENET C, V160C, P118, DOI 10.1002/ajmg.c.31327
Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005
Commission on Classification and Terminology of the International League Against Epilepsy, 1989, EPILEPSIA, V30, P389
Cossette P., 2012, JASPERS BASIC MECH E
de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
Dibbens LM, 2007, GENES BRAIN BEHAV, V6, P593, DOI 10.1111/j.1601-183X.2007.00333.x
Essrich C, 1998, NAT NEUROSCI, V1, P563
Fang M, 2011, SYNAPSE, V65, P1006, DOI 10.1002/syn.20928
Forstera B, 2010, BRAIN, V133, P3778, DOI 10.1093/brain/awq298
Fritschy JM, 2008, TRENDS NEUROSCI, V31, P257, DOI 10.1016/j.tins.2008.02.006
Gonzalez MI, 2013, EPILEPSIA, V54, P616, DOI 10.1111/epi.12063
HAUSER WA, 1993, EPILEPSIA, V34, P453, DOI 10.1111/j.1528-1157.1993.tb02586.x
Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
Herweg J, 2012, J BIOL CHEM, V287, P12645, DOI 10.1074/jbc.M112.341826
Jallon P, 2001, EPILEPSIA, V42, P464, DOI 10.1046/j.1528-1157.2001.31400.x
Kasai H, 2003, TRENDS NEUROSCI, V26, P360, DOI 10.1016/S0166-2236(03)00162-0
KIRSCH J, 1993, NATURE, V366, P745, DOI 10.1038/366745a0
Kowalczyk S, 2013, EUR J NEUROSCI, V37, P544, DOI 10.1111/ejn.12078
Lal D, 2013, EPILEPSIA, V54, P265, DOI 10.1111/epi.12084
Lardi-Studler B, 2007, J CELL SCI, V120, P1371, DOI 10.1242/jcs.003905
Lionel AC, 2013, HUM MOL GENET, V22, P2055, DOI 10.1093/hmg/ddt056
Lynch JW, 2004, PHYSIOL REV, V84, P1051, DOI 10.1152/physrev.00042.2003
Macdonald RL, 2010, J PHYSIOL-LONDON, V588, P1861, DOI 10.1113/jphysiol.2010.186999
Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
Mefford HC, 2011, ANN NEUROL, V70, P974, DOI 10.1002/ana.22645
Moller RS, 2013, EPILEPSIA, V54, P256, DOI 10.1111/epi.12078
Mukherjee J, 2011, J NEUROSCI, V31, P14677, DOI 10.1523/JNEUROSCI.2001-11.2011
Nicoletti P, 2012, ONCOLOGIST, V17, P279, DOI 10.1634/theoncologist.2011-0202
Noebels JL, 2003, ANNU REV NEUROSCI, V26, P599, DOI 10.1146/annurev.neuro.26.010302.081210
Nordli DR, 2005, EPILEPSIA, V46, P48, DOI 10.1111/j.1528-1167.2005.00313.x
Reiss J, 2001, AM J HUM GENET, V68, P208, DOI 10.1086/316941
REUTENS DC, 1992, LANCET, V339, P362, DOI 10.1016/0140-6736(92)91679-3
Schwarz G, 2001, J MOL BIOL, V312, P405, DOI 10.1006/jmbi.2001.4952
Stallmeyer B, 1999, P NATL ACAD SCI USA, V96, P1333, DOI 10.1073/pnas.96.4.1333
Tretter V, 2008, J NEUROSCI, V28, P1356, DOI 10.1523/JNEUROSCI.5050-07.2008
Tretter V, 2011, J BIOL CHEM, V286, P37702, DOI 10.1074/jbc.M111.291336
Veldman A, 2010, PEDIATRICS, V125, pE1249, DOI 10.1542/peds.2009-2192
Vlachos A., 2012, CEREB CORTEX
Vollmar C, 2012, NEUROLOGY, V78, P1555, DOI 10.1212/WNL.0b013e3182563b44
Werhahn KJ, 2000, EPILEPSY RES, V41, P179, DOI 10.1016/S0920-1211(00)00136-4
Ziemann U, 1996, ANN NEUROL, V40, P367, DOI 10.1002/ana.410400306
NR 48
TC 5
Z9 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
EI 1095-953X
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD JUL
PY 2014
VL 67
BP 88
EP 96
DI 10.1016/j.nbd.2014.02.001
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA AH9PU
UT WOS:000336475100010
PM 24561070
ER
PT J
AU Ben-Sasson, A
Gill, SV
AF Ben-Sasson, Ayelet
Gill, Simone V.
TI Motor and language abilities from early to late toddlerhood: Using
formalized assessments to capture continuity and discontinuity in
development
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE MSEL; Developmental tests; Developmental change; Toddler; Discontinuity;
ASD
ID AUTISM SPECTRUM DISORDER; FOLLOW-UP; CHILDREN; INFANTS; STABILITY;
CHILDHOOD; VARIABILITY; OUTCOMES; RISK
AB Developmental tests reflect the premise that decreases in skills over time should be a sign of atypical development. In contrast, from a psychological perspective, discontinuity may be viewed as a normal part of typical development. This study sought to describe the variability in patterns of continuity and discontinuity in developmental scores over time. Seventy-six toddlers (55% boys) from a larger screening study were evaluated at 13 and 30 months using the Mullen Scales of Early Development (MSEL) in five areas: gross motor, fine motor, visual perception, receptive language, and expressive language. Parents completed the First Year Inventory (FYI) at 12 months as well. At 30 months, 23.68% of the sample received a clinical diagnosis (e.g., developmental delay, autism spectrum disorder [ASD]). Toddlers were classified as stable, increasing, or decreasing by at least 1.5 standard deviations (SD) on their scores in each of the five MSEL areas from 13 to 30 months. Between 3.9% and 51.3% of the sample was classified as increasing and 0-23.7% as decreasing across areas. Decreases in motor areas were associated with increases in language areas. None of the toddlers showed decreases greater than 1.5 SD on their MSEL composite scores. There was no single pattern that characterized a certain diagnosis. Higher FYI sensory-regulatory risk was associated with decreases in gross motor. Lower FYI risk was linked with increases in receptive language. Developmental discontinuity in specific developmental areas was the rule rather than the exception. Interpretations of decreases in developmental levels must consider concurrent increases in skill during this emerging period. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ben-Sasson, Ayelet] Univ Haifa, Fac Social Welf & Hlth Sci, Dept Occupat Therapy, IL-31905 Haifa, Israel.
[Gill, Simone V.] Boston Univ, Coll Hlth & Rehabil Sci, Sargent Coll, Dept Occupat Therapy, Boston, MA 02215 USA.
RP Ben-Sasson, A (reprint author), Univ Haifa, Fac Social Welf & Hlth Sci, Dept Occupat Therapy, IL-31905 Haifa, Israel.
EM asasson@univ.haifa.ac.il
CR Adolph KE, 2008, PSYCHOL REV, V115, P527, DOI 10.1037/0033-295X.115.3.527
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baranek GT, 2003, 1 YEAR INVENTORY FYI
Begovac I, 2009, PSYCHIAT DANUB, V21, P310
Ben-Sasson A., 2013, J DEV NEUROREHABILIT
Ben-Sasson A, 2012, J AUTISM DEV DISORD, V42, P1906, DOI 10.1007/s10803-011-1436-1
Berger SE, 2010, CHILD DEV, V81, P1367, DOI 10.1111/j.1467-8624.2010.01478.x
Bornman J, 2010, J POLICY PRACT INTEL, V7, P111, DOI 10.1111/j.1741-1130.2010.00254.x
Center for Disease Control, 2013, AUST SPECTR DIS ASDS
Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
Clegg J, 2005, J CHILD PSYCHOL PSYC, V46, P128, DOI 10.1111/j.1469-7610.2004.00342.x
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Darrah J, 2003, EARLY HUM DEV, V72, P97, DOI 10.1016/S0378-3782(03)00027-6
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Dietz C, 2007, EUR CHILD ADOLES PSY, V16, P405, DOI 10.1007/s00787-007-0614-3
Dix T, 2007, CHILD DEV, V78, P1204, DOI 10.1111/j.1467-8624.2007.01061.x
Duffield TC, 2013, J CLIN EXP NEUROPSYC, V35, P867, DOI 10.1080/13803395.2013.827156
Hack M, 2005, PEDIATRICS, V116, P333, DOI 10.1542/peds.2005-0173
Horovitz M, 2010, DEV NEUROREHABIL, V13, P390, DOI 10.3109/17518423.2010.501431
Kantzer AK, 2013, RES DEV DISABIL, V34, P2900, DOI 10.1016/j.ridd.2013.06.016
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
Kuhl PK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064967
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Macari SL, 2012, J AUTISM DEV DISORD, V42, P2636, DOI 10.1007/s10803-012-1521-0
Mitchell CM, 2011, DEV PSYCHOL, V47, P991, DOI 10.1037/a0024011
Mullen E, 1995, MULLEN SCALES EARLY
Rea L. M., 1992, DESIGNING CONDUCTING
Reynolds S, 2009, AM J OCCUP THER, V63, P433
Reznick JS, 2007, J AUTISM DEV DISORD, V37, P1691, DOI 10.1007/s10803-006-0303-y
SLOMKOWSKI CL, 1992, DEV PSYCHOL, V28, P1090, DOI 10.1037/0012-1649.28.6.1090
Thelen E, 1998, NEUROSCI BIOBEHAV R, V22, P507, DOI 10.1016/S0149-7634(97)00037-7
Tittnich E., 1990, J CHILD CONT SOC, V21, P15
Turner-Brown L. M., 2012, AUTISM, V17, P527
van Dijk M, 2007, INFANT CHILD DEV, V16, P7, DOI 10.1002/icd.506
Vereijken B, 2010, PHYS THER, V90, P1850, DOI 10.2522/ptj.20100019
Yang P, 2011, J INTELL DISABIL RES, V55, P453, DOI 10.1111/j.1365-2788.2011.01396.x
Yang PC, 2010, RES DEV DISABIL, V31, P895, DOI 10.1016/j.ridd.2010.02.011
NR 38
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1425
EP 1432
DI 10.1016/j.ridd.2014.03.036
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500001
PM 24751905
ER
PT J
AU Ouyang, LJ
Grosse, SD
Riley, C
Bolen, J
Bishop, E
Raspa, M
Bailey, DB
AF Ouyang, Lijing
Grosse, Scott D.
Riley, Catharine
Bolen, Julie
Bishop, Ellen
Raspa, Melissa
Bailey, Donald B., Jr.
TI A comparison of family financial and employment impacts of fragile X
syndrome, autism spectrum disorders, and intellectual disability
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Fragile X syndrome; Intellectual disability; Autism spectrum disorders;
Caregiver impacts
ID NATIONAL PROFILE; CHILDHOOD AUTISM; UNITED-STATES; DOWN-SYNDROME;
CHILDREN; HEALTH; CARE; BURDEN; POPULATION; VARIABLES
AB This study compares the family financial and employment impacts of having a child with fragile X syndrome (FXS), autism spectrum disorder (ASD), or intellectual disabilities (ID). Data from a 2011 national survey of families of children with FXS were matched with data from the National Survey of Children with Special Health Care Needs 2009-2010 to form four analytic groups: children with FXS (n = 189), children with special health care needs with ASD only (n = 185), ID only (n= 177), or both ASD and ID (n = 178). Comparable percentages of parents of children with FXS (60%) and parents of children with both ASD and ID (52%) reported that their families experienced a financial burden as a result of the condition, both of which were higher than the percentages of parents of children with ASD only (39%) or ID only (29%). Comparable percentages of parents of children with FXS (40%) and parents of children with both ASD and ID (46%) reported quitting employment because of the condition, both of which were higher than the percentages of parents of children with ID only (25%) or ASD only (25%). In multivariate analyses controlling for co-occurring conditions and functional difficulties and stratified by age, adjusted odds ratios for the FXS group aged 12-17 years were significantly elevated for financial burden (2.73, 95% CI 1.29-5.77), quitting employment (2.58, 95% CI 1.18-5.65) and reduced hours of work (4.34, 95% CI 2.08-9.06) relative to children with ASD only. Among children aged 5 11 years, the adjusted odds ratios for the FXS group were elevated but statistically insignificant for financial burden (1.63, 95% CI 0.85-3.14) and reducing hours of work (1.34, 95% CI 0.68-2.63) relative to children with ASD only. Regardless of condition, co-occurring anxiety or seizures, limits in thinking, reasoning, or learning ability, and more irritability were significantly associated with more caregiver financial and employment impacts. Proper management of anxiety or seizures and functional difficulties of children with FXS or other developmental disabilities may be important in alleviating adverse family caregiver impacts. Published by Elsevier Ltd.
C1 [Ouyang, Lijing; Grosse, Scott D.; Riley, Catharine; Bolen, Julie] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Bishop, Ellen; Raspa, Melissa; Bailey, Donald B., Jr.] RTI Int, Res Triangle Pk, NC USA.
RP Ouyang, LJ (reprint author), 1600 Clifton Rd NE,Mail Stop E-88, Atlanta, GA 30329 USA.
EM louyang@cdc.gov
CR Aman M., 1994, ABERRANT BEHAV CHECK
Bailey D. B., 2011, AJIDD-AM J INTELLECT, V115, P447
Bailey DB, 2012, J DEV BEHAV PEDIATR, V33, P705, DOI 10.1097/DBP.0b013e318272dcbc
Bailey DB, 2008, AM J MED GENET A, V146A, P720, DOI 10.1002/ajmg.a.32240
Berry-Kravis E, 2010, AJIDD-AM J INTELLECT, V115, P461, DOI [10.1352/1944-7558-115.6.461, 10.1352/194475581156461]
Bethell CD, 2002, AMBUL PEDIATR, V2, P38, DOI 10.1367/1539-4409(2002)002<0038:ICWSHC>2.0.CO;2
Blackwell M, 2009, STATA J, V9, P524
Centers for Disease Control and Prevention National Center for Health Statistics, 2011, 2009 2010 NAT SURV C
Cidav Z, 2012, PEDIATRICS, V129, P617, DOI 10.1542/peds.2011-2700
Coffee B, 2009, AM J HUM GENET, V85, P503, DOI 10.1016/j.ajhg.2009.09.007
Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
Cornish K, 2008, J INTELL DISABIL RES, V52, P469, DOI 10.1111/j.1365-2788.2008.01056.x
Iacus SM, 2012, POLIT ANAL, V20, P1, DOI 10.1093/pan/mpr013
Irazabal M, 2012, RES DEV DISABIL, V33, P796, DOI 10.1016/j.ridd.2011.12.002
Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
Lewis P, 2006, J INTELL DISABIL RES, V50, P532, DOI 10.1111/j.1365-2788.2006.00803.x
Lollar DJ, 2012, PEDIATRICS, V129, pE714, DOI 10.1542/peds.2011-0780
Maes B, 2003, J INTELL DISABIL RES, V47, P447, DOI 10.1046/j.1365-2788.2003.00513.x
Martorell A, 2011, RES DEV DISABIL, V32, P2847, DOI 10.1016/j.ridd.2011.05.021
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
McGrath RJ, 2011, J PEDIATR-US, V159, P535, DOI 10.1016/j.jpeds.2011.04.019
Montes G, 2008, PEDIATRICS, V122, pE202, DOI 10.1542/peds.2007-3037
Montes G, 2008, PEDIATRICS, V121, pE821, DOI 10.1542/peds.2007-1594
Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
Okumura Megumi J, 2009, Pediatrics, V124 Suppl 4, pS392, DOI 10.1542/peds.2009-1255J
Ouyang L, 2010, J INTELL DISABIL RES, V54, P918, DOI 10.1111/j.1365-2788.2010.01320.x
Peacock G, 2012, J DEV BEHAV PEDIATR, V33, P2, DOI 10.1097/DBP.0b013e31823969de
Peprah E, 2012, ANN HUM GENET, V76, P178, DOI 10.1111/j.1469-1809.2011.00694.x
Saul RA, 1993, GENEREVIEWS
Schieve LA, 2011, DISABIL HEALTH J, V4, P68, DOI 10.1016/j.dhjo.2010.06.001
NR 30
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1518
EP 1527
DI 10.1016/j.ridd.2014.04.009
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500008
PM 24755230
ER
PT J
AU Poon, KK
Ooi, N
Bull, R
Bailey, DB
AF Poon, Kenneth K.
Ooi, Nona
Bull, Rebecca
Bailey, Donald B., Jr.
TI Psychometric validation of the Family Outcome Survey-Revised in
Singapore
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Early childhood intervention; Family Outcomes Survey-Revised; Singapore
ID AUTISM SPECTRUM DISORDERS; EARLY INTERVENTION; CHILDREN; DISABILITIES;
DIAGNOSIS; SERVICES; PARENTS; FATHERS; MOTHERS; STRESS
AB This study sought to examine the construct validity of the Family Outcomes Survey-Revised (FOS-R) in Singapore, describe the extent to which family outcomes of early childhood intervention (ECI) are attained, and obtain caregivers perception on the extent to which ECI has served their needs. The FOS-R was translated into Chinese (simplified) and Malay for use in Singapore. Bilingual (i.e., English-Chinese and English-Malay) versions of the instrument were distributed to caregivers of young children with disabilities receiving ECI in four centers in Singapore. A total of 291 surveys were available for analyses (response rate of 43.1%). Confirmatory factor analyses indicated that there was a fit between the current data set and the FOS-R structure proposed by the developers. Overall, the participants reported moderately high attainment of family outcomes. They also reported that the ECI programs were mostly helpful. Other aspects of the cross-cultural application of instruments were considered and implications for local service provision as well as directions for future research were discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Poon, Kenneth K.; Ooi, Nona; Bull, Rebecca] Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore.
[Bailey, Donald B., Jr.] RTI Int, Durham, NC USA.
RP Poon, KK (reprint author), Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore.
EM kenpoon@gmail.com
CR BAILEY DB, 1988, J SPEC EDUC, V22, P117
Bailey D. B., 2006, FAMILY OUTCOMES SURV
Bailey D. B., 2001, J EARLY INTERVENTION, V24, P1
Bailey DB, 2011, J EARLY INTERVENTION, V33, P6, DOI 10.1177/1053815111399441
Bailey DB, 2006, J EARLY INTERVENTION, V28, P227, DOI 10.1177/105381510602800401
Bailey DB, 2008, INFANT YOUNG CHILD, V21, P194
Berry J. W., 1992, CROSS CULTURAL PSYCH
Brooks-Gunn J., 2000, HDB EARLY CHILDHOOD, P549
Bruder MB, 2010, EXCEPT CHILDREN, V76, P339
Byrne BM, 2005, J PERS ASSESS, V85, P17, DOI 10.1207/s15327752jpa8501_02
Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
Dunst C., 1988, ENABLING EMPOWERING
Dunst C. J., 2006, FAMILY CHILD BENEFIT
Dunst CJ, 2007, MENT RETARD DEV D R, V13, P370, DOI 10.1002/mrdd.20176
Enabling Masterplan 2012-2016 Steering Committee, 2012, EN MAST 2012 2016 MA
Enriquez M., 2009, DIABETES ED, V35, P428
Epley PH, 2011, J EARLY INTERVENTION, V33, P201, DOI 10.1177/1053815111425929
Ghosh S, 2009, INT REV RES MENT RET, V37, P179, DOI 10.1016/S0074-7750(09)37006-8
Goin-Kochel RP, 2006, AUTISM, V10, P439, DOI 10.1177/1362361306066601
Hamamura T, 2008, PERS INDIV DIFFER, V44, P932, DOI 10.1016/j.paid.2007.10.034
Hoffman L, 2006, J MARRIAGE FAM, V68, P1069, DOI 10.1111/j.1741-3737.2006.00314.x
King G, 1999, J PEDIATR PSYCHOL, V24, P41, DOI 10.1093/jpepsy/24.1.41
Kline R. B., 2010, PRINCIPLES PRACTICE, V3rd
Moh TA, 2012, RES AUTISM SPECT DIS, V6, P293, DOI 10.1016/j.rasd.2011.05.011
Muthen L. K., 1998, MPLUS USERS GUIDE
Piotrowski CC, 2009, J DEV BEHAV PEDIATR, V30, P91, DOI 10.1097/DBP.0b013e3181976a95
Poon K. K., 2012, INFANTS YOUNG CHILDR, V25, P1
Poon KK, 2013, AJIDD-AM J INTELLECT, V118, P95, DOI 10.1352/1944-7558-118.2.95
Sameroff A.J., 2009, T MODEL DEV CHILDREN
Siklos S, 2007, RES DEV DISABIL, V28, P9, DOI 10.1016/j.ridd.2005.09.003
Simeonsson RJ, 1991, ABILITIES INDEX
Singapore Department of Statistics, 2011, CENS POP 2010 STAT R
Trivette C. M., 2005, DEC RECOMMENDED PRAC, P107
Turnbull A., 2000, HDB EARLY CHILDHOOD, P618
Ueda K., 2013, 3 INT ASS SCI STUD I
UPSHUR CC, 1991, J EARLY INTERVENTION, V15, P345
NR 36
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1534
EP 1543
DI 10.1016/j.ridd.2014.03.047
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500010
PM 24763378
ER
PT J
AU Tsai, WH
Hwang, YS
Hung, TY
Weng, SF
Lin, SJ
Chang, WT
AF Tsai, Wen-Hui
Hwang, Yea-Shwu
Hung, Te-Yu
Weng, Shih-Feng
Lin, Shio-Jean
Chang, Wen-Tsan
TI Association between mechanical ventilation and neurodevelopmental
disorders in a nationwide cohort of extremely low birth weight infants
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Attention-deficit/hyperactivity disorder; Autism spectrum disorder;
Cerebral palsy; Extremely low birth weight infants; Intellectual
disability; Mechanical ventilation
ID DEFICIT-HYPERACTIVITY DISORDER; NEONATAL RESEARCH NETWORK; POSITIVE
AIRWAY PRESSURE; CEREBRAL-PALSY; PRETERM INFANTS; RISK-FACTORS;
BRONCHOPULMONARY DYSPLASIA; INTELLECTUAL DISABILITY; SEX
STRATIFICATIONS; HEALTH-INSURANCE
AB Mechanical ventilation for preterm infants independently contributes to poor neurodevelopmental performance. However, few studies have investigated the association between the duration of mechanical ventilation and the risk for various developmental disorders in extremely low birth weight (ELBW) (<1000 g) infants. Using a large nationwide database, we did a 10-year retrospective follow-up study to explore the effect of mechanical ventilation on the incidence of cerebral palsy (CP), autism spectrum disorder (ASD), intellectual disability (ID), and attention-deficit/hyperactivity disorder (ADHD) in ELBW infants born between 1998 and 2001. Seven hundred twenty-eight ELBW infants without diagnoses of brain insults or focal brain lesions in the initial hospital stay were identified and divided into three groups (days on ventilator: <= 2, 3-14, >= 15 days). After adjusting for demographic and medical factors, the infants in the 15 days group had higher risks for CP (adjusted hazard ratio: 2.66; 95% confidence interval: 1.50-4.59; p < 0.001) and ADHD (adjusted hazard ratio: 1.95; 95% confidence interval: 1.02-3.76; p < 0.05), than did infants in the 2 days group. The risk for ASD or ID was not significantly different between the three groups. We conclude that mechanical ventilation for 15 days increased the risk for CP and ADHD in ELBW infants even without significant neonatal brain damage. Developing a brain-protective respiratory support strategy in response to real-time cerebral hemodynamic and oxygenation changes has the potential to improve neurodevelopmental outcomes in ELBW infants. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Tsai, Wen-Hui] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 701, Taiwan.
[Tsai, Wen-Hui] Chi Mei Med Ctr, Div Neonatol, Tainan 710, Taiwan.
[Hwang, Yea-Shwu] Natl Cheng Kung Univ, Coll Med, Dept Occupat Therapy, Tainan 701, Taiwan.
[Hung, Te-Yu; Lin, Shio-Jean] Chi Mei Med Ctr, Dept Pediat, Tainan 710, Taiwan.
[Weng, Shih-Feng] Chi Mei Med Ctr, Dept Med Res, Tainan 710, Taiwan.
[Chang, Wen-Tsan] Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, Tainan 701, Taiwan.
[Chang, Wen-Tsan] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan.
RP Chang, WT (reprint author), Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, 1 Univ Rd, Tainan 701, Taiwan.
EM wtchang@mail.ncku.edu.tw
CR Alexandrou G, 2014, ACTA PAEDIATR, V103, P48, DOI 10.1111/apa.12445
Bilder DA, 2013, AJIDD-AM J INTELLECT, V118, P156, DOI 10.1352/1944-7558-118.2.156
BOZYNSKI MEA, 1987, PEDIATRICS, V79, P670
Brown NC, 2006, PEDIATRICS, V118, P2461, DOI 10.1542/peds.2006-0880
Buck C., 2003, 2001 ICD 9 CM 1 3
Chen CY, 2007, PEDIATRICS, V119, pE435, DOI 10.1542/peds.2006-1477
Chen HF, 2010, HEPATOLOGY, V52, P155, DOI 10.1002/hep.23641
Cheng TM, 2003, HEALTH AFFAIR, V22, P61, DOI 10.1377/hlthaff.22.3.61
Chiang TL, 1997, HEALTH POLICY, V39, P225, DOI 10.1016/S0168-8510(96)00877-9
Chien IC, 2012, SOC PSYCH PSYCH EPID, V47, P1885, DOI 10.1007/s00127-012-0501-1
Collins MP, 2001, PEDIATR RES, V50, P712, DOI 10.1203/00006450-200112000-00014
COWAN F, 1987, ACTA PAEDIATR SCAND, V76, P239, DOI 10.1111/j.1651-2227.1987.tb10454.x
Dammann O, 2008, CLIN PERINATOL, V35, P643, DOI 10.1016/j.clp.2008.07.011
Drougia A, 2007, EARLY HUM DEV, V83, P541, DOI 10.1016/j.earlhumdev.2006.10.004
Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250
Gustafsson P, 2011, DEV MED CHILD NEUROL, V53, P263, DOI 10.1111/j.1469-8749.2010.03820.x
Hack M, 2009, J DEV BEHAV PEDIATR, V30, P122, DOI 10.1097/DBP.0b013e31819e6a16
Hansen BM, 2004, ACTA PAEDIATR, V93, P185, DOI 10.1080/08035250310008230
Hintz SR, 2005, PEDIATRICS, V115, P696, DOI 10.1542/peds.2004-0569
Indredavik MS, 2010, J DEV BEHAV PEDIATR, V31, P286, DOI 10.1097/DBP.0b013e3181d7b1d3
Johnson S, 2010, J AM ACAD CHILD PSY, V49, P453, DOI 10.1016/j.jaac.2010.02.002
Kobaly K, 2008, PEDIATRICS, V121, P73, DOI 10.1542/peds.2007-1444
KORNER AF, 1993, J DEV BEHAV PEDIATR, V14, P106
Lau C, 2013, PEDIATRICS, V131, P855, DOI 10.1542/peds.2012-2471
Lemons JA, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.1.e1
Limperopoulos C, 2008, PEDIATRICS, V122, pE1006, DOI 10.1542/peds.2008-0768
Loeliger M, 2006, PEDIATRICS, V118, P1640, DOI 10.1542/peds.2006-0653
Lu JFR, 2003, HEALTH AFFAIR, V22, P77, DOI 10.1377/hlthaff.22.3.77
Miller SP, 2005, J PEDIATR-US, V147, P609, DOI 10.1016/j.jpeds.2005.06.033
Neufeld Michael D, 2005, J Perinatol, V25, P108, DOI 10.1038/sj.jp.7211219
O'Leary C, 2013, DEV MED CHILD NEUROL, V55, P271, DOI 10.1111/dmcn.12029
Pogribna U, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072974
Powell K, 2006, J MATERN-FETAL NEO M, V19, P43, DOI 10.1080/14767050500363519
Saldir M, 2010, AM J PERINAT, V27, P121, DOI 10.1055/s-0029-1224863
SHAH AR, 1992, J PEDIATR-US, V120, P769, DOI 10.1016/S0022-3476(05)80246-X
Sun Y, 2012, DIABETES CARE, V35, P1047, DOI 10.2337/dc11-1511
Thomas CW, 2012, INDIAN J PEDIATR, V79, P218, DOI 10.1007/s12098-011-0535-5
Tran U, 2005, EARLY HUM DEV, V81, P555, DOI 10.1016/j.earthumdev.2004.12.009
Trittmann JK, 2013, EUR J PEDIATR, V172, P1173, DOI 10.1007/s00431-013-2016-5
van Kooij BJM, 2012, AM J NEURORADIOL, V33, P188, DOI 10.3174/ajnr.A2723
Vohr BR, 2005, PEDIATRICS, V116, P635, DOI 10.1542/peds.2004-2247
Vohr BR, 2000, PEDIATRICS, V105, P1216, DOI 10.1542/peds.105.6.1216
Wilson-Costello D, 1998, PEDIATRICS, V102, P315, DOI 10.1542/peds.102.2.315
NR 43
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1544
EP 1550
DI 10.1016/j.ridd.2014.03.048
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500011
PM 24769371
ER
PT J
AU Hsu, CF
AF Hsu, Ching-Fen
TI Modality effect on contextual integration in people with Williams
syndrome
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Modality effect; Contextual integration; Central coherence;
Syndrome-general deficiency; Williams syndrome
ID INFORMATION INTEGRATION; COHERENCE; AUTISM; WEAK
AB In this study meaningful social stimuli were used as probes in a task requiring the judgment of semantic appropriateness to investigate contextual integration ability to test the ability of people with Williams syndrome (WS) to integrate information, as opposed to the use of meaningless syllables in audiovisual studies (the McGurk effect). Participants were presented with background auditory primes followed by targets that were either congruent or incongruent with the prime. Two modes of target were presented: a visual target (AV task) or an auditory target (AA task). Participants were asked to respond yes to contextually appropriate pairs and no to those that were contextually inappropriate. The congruency effect was measured as an index of successful central coherence. Similar to normally developing controls, people with WS showed shorter response latencies and greater accuracy in recognizing congruent pairs compared with incongruent pairs. Their performance did not differ from that of controls matched by mental age, but was inferior to that of controls matched by chronological age. The results revealed generalized contextual integration for auditory primes in both tasks, consistent with previous studies using visual presentation of social-related stimuli in people with WS (Hsu, 2013a, 2013c). Further demonstration of the presence of a modality effect on contextual coherence implies that cross-modal learning may be advantageous compared with unimodal learning. (C) 2014 Elsevier Ltd. All rights reserved.
C1 Huafan Univ, Dept Foreign Languages & Literature, Taipei 22301, Taiwan.
RP Hsu, CF (reprint author), Huafan Univ, Dept Foreign Languages & Literature, 1 Huafan Rd, Taipei 22301, Taiwan.
EM chinghsu@cc.hfu.edu.tw
CR Atkinson J, 1997, NEUROREPORT, V8, P1919, DOI 10.1097/00001756-199705260-00025
Bellugi U, 2000, J COGNITIVE NEUROSCI, V12, P7, DOI 10.1162/089892900561959
Bohning M., 2001, NEUROPSYCHOLOGIA, V1349, P1
Chen R. H., 2007, WECHSLER SCALE INTEL
Chen R. H., 2002, WECHSLER ADULT INTEL
Frith U., 1989, AUTISM EXPLAINING EN
Gothelf D, 2006, NEUROLOGY, V66, P390, DOI 10.1212/01.wnl.0000196643.35395.5f
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Hsu C. F., 2007, P 6 IEEE INT C DEV L, V6, P48
Hsu CF, 2013, RES DEV DISABIL, V34, P932, DOI 10.1016/j.ridd.2012.11.015
Hsu CF, 2011, RES DEV DISABIL, V32, P781, DOI 10.1016/j.ridd.2010.11.001
Hsu CF, 2013, RES DEV DISABIL, V34, P3332, DOI 10.1016/j.ridd.2013.06.031
Hsu CF, 2013, RES DEV DISABIL, V34, P4319, DOI 10.1016/j.ridd.2013.09.002
Jarvinen-Pasley A, 2010, NEUROPSYCHOLOGIA, V48, P456, DOI 10.1016/j.neuropsychologia.2009.10.003
Korenberg J. R., 2000, JOURNEY COGNITION BR, P147
Lense M. D., 2014, SOCIAL COGN IN PRESS
Majerus S, 2003, NEUROCASE, V9, P390, DOI 10.1076/neur.9.5.390.16558
Stromme P, 2002, J CHILD NEUROL, V17, P269, DOI 10.1177/088307380201700406
Thornton-Wells TA, 2010, AJIDD-AM J INTELLECT, V115, P172, DOI 10.1352/1944-7588-115.172
Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
NR 20
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1571
EP 1578
DI 10.1016/j.ridd.2014.03.049
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500014
PM 24769430
ER
PT J
AU Pratt, ML
Leonard, HC
Adeyinka, H
Hill, EL
AF Pratt, Michelle L.
Leonard, Hayley C.
Adeyinka, Hanna
Hill, Elisabeth L.
TI The effect of motor load on planning and inhibition in developmental
coordination disorder
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Executive function; Developmental coordination disorder; Planning;
Inhibition; Motor development
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; EXECUTIVE FUNCTION DEFICITS;
AUTISM SPECTRUM DISORDERS; WORKING-MEMORY; CHILDREN; PROFILES;
PERFORMANCE; DYSFUNCTION; LANGUAGE; ABILITY
AB Previous research has reported mixed findings regarding executive function (EF) abilities in developmental coordination disorder (DCD), which is diagnosed on the basis of significant impairments in motor skills. The current study aimed to assess whether these differences in study outcomes could result from the relative motor loads of the tasks used to assess EF in DCD. Children with DCD had significant difficulties on measures of inhibition and planning compared to a control group, although there were no significant correlations between motor skills and EF task performance in either group. The complexity of the response, as well as the component skills required in EF tasks, should be considered in future research to ensure easier comparison across studies and a better understanding of EF in DCD over development. (C )2014 Elsevier Ltd. All rights reserved.
C1 [Pratt, Michelle L.; Leonard, Hayley C.; Adeyinka, Hanna; Hill, Elisabeth L.] Univ London, Dept Psychol, London SE14 6NW, England.
RP Hill, EL (reprint author), Univ London, Dept Psychol, London SE14 6NW, England.
EM h.leonard@gold.ac.uk
CR Alloway TP, 2011, CHILD NEUROPSYCHOL, V17, P483, DOI 10.1080/09297049.2011.553590
Alloway TP, 2008, J LEARN DISABIL-US, V41, P251, DOI 10.1177/0022219408315815
Alloway TP, 2007, J EXP CHILD PSYCHOL, V96, P20, DOI 10.1016/j.jecp.2006.07.002
Altshuler L, 2007, PSYCHIAT SERV, V58, P1441, DOI 10.1176/appi.ps.58.11.1441
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Anderson P, 2002, CHILD NEUROPSYCHOL, V8, P71
Best JR, 2010, CHILD DEV, V81, P1641, DOI 10.1111/j.1467-8624.2010.01499.x
Biederman J, 2004, J CONSULT CLIN PSYCH, V72, P757, DOI 10.1037/0022-006X.72.5.757
Diamond A, 2013, ANNU REV PSYCHOL, V64, P135, DOI 10.1146/annurev-psych-113011-143750
Garcia-Villamisar D, 2007, J INTELL DISABIL RES, V51, P142, DOI 10.1111/j.1365-2788.2006.00854.x
Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504
Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
Hill E. L, 1998, CHILDREN DEV DISORDE
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Korkman M., 1998, NEPSY DEV NEUROPSYCH
Livesey D, 2006, HUM MOVEMENT SCI, V25, P50, DOI 10.1016/j.humov.2005.10.008
Mandich A, 2002, BRAIN COGNITION, V50, P150, DOI 10.1016/S0278-2626(02)00020-9
Michel E, 2011, CHILD NEUROPSYCHOL, V17, P151, DOI 10.1080/09297049.2010.525501
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
Nigg JT, 2000, PSYCHOL BULL, V126, P220, DOI 10.1037//0033-2909.126.2.220
Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
Piek JP, 2004, ARCH CLIN NEUROPSYCH, V19, P1063, DOI 10.1016/j.acn.2003.12.007
Piek JP, 2007, DEV MED CHILD NEUROL, V49, P678
Querne L, 2008, BRAIN RES, V1244, P89, DOI 10.1016/j.brainres.2008.07.066
Rigoli D, 2012, DEV MED CHILD NEUROL, V54, P1025, DOI 10.1111/j.1469-8749.2012.04403.x
ROSENBAUM DA, 1990, ATTENTION PERFORM, V8, P321
Smyth MM, 1997, J CHILD PSYCHOL PSYC, V38, P1023, DOI 10.1111/j.1469-7610.1997.tb01619.x
Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/h0054651
van Swieten L. M., 2009, J EXPT PSYCHOL HUMAN, V36, P493
Wechsler D., 2004, WECHSLER INTELLIGENC
Wilson PH, 2012, DEV MED CHILD NEUROL, V55, P217
Wisdom SN, 2007, EUR CHILD ADOLES PSY, V16, P178, DOI 10.1007/s00787-006-0586-8
Wright D. B., 2011, J EXPT PSYCHOPATHOLO, V2, P252
Wuang YP, 2011, RES DEV DISABIL, V32, P1669, DOI 10.1016/j.ridd.2011.02.021
NR 36
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1579
EP 1587
DI 10.1016/j.ridd.2014.04.008
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500015
PM 24770468
ER
PT J
AU Sun, X
Allison, C
Auyeung, B
Matthews, FE
Zhang, ZX
Baron-Cohen, S
Brayne, C
AF Sun, Xiang
Allison, Carrie
Auyeung, Bonnie
Matthews, Fiona E.
Zhang, Zhixiang
Baron-Cohen, Simon
Brayne, Carol
TI Comparison between a Mandarin Chinese version of the Childhood Autism
Spectrum Test and the Clancy Autism Behaviour Scale in mainland China
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Screening; Diagnosis; Epidemiology; CAST; CABS; China
ID PERVASIVE DEVELOPMENTAL DISORDERS; ASPERGER-SYNDROME TEST; DIAGNOSTIC
INTERVIEW; MENTAL-RETARDATION; TEST CAST; PREVALENCE; CHILDREN;
IDENTIFICATION; QUOTIENT; UK
AB A Mandarin Chinese version of the Childhood Autism Spectrum Test (CAST) and Clancy Autism Behaviour Scale (CABS) were applied to 150 children aged 4-11 years old from clinical settings and mainstream schools in Beijing. All the children were further assessed using the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview-Revised (ADI-R). The validity of two instruments on screening of ASC was examined and compared using receiver operating characteristic (ROC) curve analysis. The validity of CAST (sensitivity: 89%, specificity: 80%, PPV: 70%) was better than the CABS (sensitivity: 58%, specificity: 84%, PPV: 65%). The area under the curve (AUC) of the CAST (AUC = 0.90) was significantly higher than the CABS (AUC = 0.79, p = 0.0002). The Mandarin CAST demonstrated a better validity in distinguishing children with ASC from children without ASC. It is an acceptable candidate as a screening instrument for ASC in large epidemiological study in Chinese population. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Sun, Xiang; Brayne, Carol] Univ Cambridge, Sch Clin Med, Cambridge Inst Publ Hlth, Cambridge CB2 0SR, England.
[Sun, Xiang; Allison, Carrie; Auyeung, Bonnie; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 2AH, England.
[Sun, Xiang] Chinese Univ Hong Kong, Prince Wales Hosp, Jockey Club Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
[Auyeung, Bonnie] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
[Matthews, Fiona E.] Cambridge Inst Publ Hlth, MRC Biostat Unit, Cambridge CB2 0SR, England.
[Zhang, Zhixiang] Peking Univ, Hosp 1, Dept Paediat, Beijing, Peoples R China.
RP Sun, X (reprint author), Univ Cambridge, Sch Clin Med, Cambridge Inst Publ Hlth, Forvie Site,Cambridge Biomed Campus, Cambridge CB2 0SR, England.
EM xs227@medschl.cam.ac.uk
CR Allison C., 2007, AUTISM, V11, P177
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2012, AUST SPECTR DIS
[Anonymous], 1993, INT STAT CLASS DIS R
Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
Auyeung B, 2009, J AUTISM DEV DISORD, V39, P1509, DOI 10.1007/s10803-009-0772-x
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
Baron-Cohen S, 2000, J ROY SOC MED, V93, P521
Berument SK, 2005, J AUTISM DEV DISORD, V35, P821, DOI 10.1007/s10803-005-0027-4
Blaxill MF, 2004, PUBLIC HEALTH REP, V119, P536, DOI 10.1016/j.phr.2004.09.003
Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
Chen Y., 2007, GUANGDONG MED J, V28, P376
CLANCY H, 1969, DEV MED CHILD NEUROL, V11, P432
COHEN J, 1968, PSYCHOL BULL, V70, P213, DOI 10.1037/h0026256
Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
KANNER L, 1957, Psychiatr Res Rep Am Psychiatr Assoc, P55
Ketelaars C, 2008, J AUTISM DEV DISORD, V38, P176, DOI 10.1007/s10803-007-0358-4
King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
Li D., 1989, CHINESE RAVEN TEST
Li J., 2005, CHINESE J CONT PEDIA, V7, P59
Li N, 2011, EPILEPSY BEHAV, V22, P786, DOI 10.1016/j.yebeh.2011.10.002
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2001, AUTISM DIAGNOSTIC OB
Papanikolaou K, 2009, J AUTISM DEV DISORD, V39, P414, DOI 10.1007/s10803-008-0639-6
Raven JC, 1938, STANDARD PROGRESSIVE
Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
Rutter M, 2003, AUSTIM DIAGNOSTIC IN
Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
South M, 2002, J AUTISM DEV DISORD, V32, P593, DOI 10.1023/A:1021211232023
Sun X., 2014, EXPLORATION UN UNPUB
Sun X., 2009, RES AUTISM SPECT DIS, V4, P156
Sun X, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-7
Sun X, 2013, RES AUTISM SPECT DIS, V7, P579, DOI 10.1016/j.rasd.2012.11.003
Tantam D, 2009, BRIT MED BULL, V89, P41, DOI 10.1093/bmb/ldp006
王瑜, 2003, [山东大学学报. 医学版, Journal of Shandong University], V41, P213
Wang Y., 2003, CHINESE J CHILD HLTH, V11, P133
Webb P, 2005, ESSENTIAL EPIDEMIOLO
Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029
Williams J., 2003, SCREENING AUSTIM SPE
Williams J, 2006, AUTISM, V10, P415, DOI 10.1177/1362361306066612
Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083
Williams JG, 2008, J AUTISM DEV DISORD, V38, P1731, DOI 10.1007/s10803-008-0558-6
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
Wu X., 2010, J MODERN MED HYGIENE, V26, P3724
张枫, 2011, [江苏医药, Jiangsu Medical Journal], V37, P1704
Zhang Q., 2006, J MED THEORY PRACTIC, V19, P586
Zhang X, 2005, BIOMED ENVIRON SCI, V18, P334
Zhang Z., 1995, J CHINA CLIN PSYCHOL, V3, P12
NR 57
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1599
EP 1608
DI 10.1016/j.ridd.2014.02.005
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500017
PM 24769432
ER
PT J
AU Hodge, D
Carollo, TM
Lewin, M
Hoffman, CD
Sweeney, DP
AF Hodge, Danelle
Carollo, Tanner M.
Lewin, Michael
Hoffman, Charles D.
Sweeney, Dwight P.
TI Sleep patterns in children with and without autism spectrum disorders:
Developmental comparisons
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Sleep; Melatonin; Development
ID HABITS QUESTIONNAIRE; TYPICAL DEVELOPMENT; AGE-CHILDREN; MELATONIN;
ADOLESCENTS; CHILDHOOD; ADULTS; DELAY
AB The present study examined age-related changes in the sleep of children with autism spectrum disorders (ASD) compared to age-related changes in the sleep of typically developing (TD) children. Participants were 108 mothers of children with ASD and 108 mothers of TD children. Participants completed a questionnaire on children's overall sleep quality that also tapped specific sleep-domains (i.e., bedtime resistance, sleep onset delay, sleep duration, sleep anxiety, night wakings, parasomnias, disordered breathing, daytime sleepiness). Results confirm significantly poorer sleep quantity and quality in children with ASD, particularly children age 6-9 years. Unlike TD children, the sleep problems of children with ASD were unlikely to diminish with age. Our findings suggest that it is important to exam specific domains of sleep as well as overall sleep patterns. Finding of significant age-related interactions suggests that the practice of combining children from wide age-ranges into a single category obfuscates potentially important developmental differences. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Hodge, Danelle; Carollo, Tanner M.; Lewin, Michael; Hoffman, Charles D.; Sweeney, Dwight P.] Calif State Univ San Bernardino, Dept Psychol, San Bernardino, CA 92407 USA.
RP Hodge, D (reprint author), Calif State Univ San Bernardino, Dept Psychol, 5500 Univ Pkwy, San Bernardino, CA 92407 USA.
EM dhodge@csusb.edu
CR Allik H, 2008, J AUTISM DEV DISORD, V38, P1625, DOI 10.1007/s10803-008-0543-0
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Arendt J, 2005, J BIOL RHYTHM, V20, P291, DOI 10.1177/0748730405277492
Arendt J., 1995, MELATONIN MAMMALIAN, p[201, 27]
Autism Society of America, 2003, DEFINING AUTISM
Arbelle S, 2001, RESEARCH BASIS FOR AUTISM INTERVENTION, P219
Didden R, 2001, RES DEV DISABIL, V22, P255, DOI 10.1016/S0891-4222(01)00071-3
Gilliam J. E., 2005, GILLIAM AUTISM RATIN
Goldman SE, 2012, J AUTISM DEV DISORD, V42, P531, DOI 10.1007/s10803-011-1270-5
Goodlin-Jones B, 2009, J AM ACAD CHILD PSY, V48, P847, DOI 10.1097/CHI.0b013e3181a8135a
Goodlin-Jones BL, 2008, J DEV BEHAV PEDIATR, V29, P82, DOI 10.1097/DBP.0b013e318163c39a
Goodlin-Jones BL, 2008, J AM ACAD CHILD PSY, V47, P930, DOI [10.1097/CHI.ObO13e3181799f7c, 10.1097/CHI.0b013e3181799f7c]
Gregory AM, 2002, J AM ACAD CHILD PSY, V41, DOI 10.1097/00004583-200208000-00015
Hering E, 1999, J AUTISM DEV DISORD, V29, P143, DOI 10.1023/A:1023092627223
Hodge D, 2012, RES AUTISM SPECT DIS, V6, P1337, DOI 10.1016/j.rasd.2012.05.009
Hodge D, 2013, J AUTISM DEV DISORD, V43, P956, DOI 10.1007/s10803-012-1639-0
Hoffman C. D., 2006, FOCUS AUTISM OTHER D, V21, P146, DOI [10.1177/10883576060210030301, DOI 10.1177/1088357]
Hoffman C. D., 2005, FOCUS AUTISM OTHER D, V20, P194, DOI [10.1177/10883576050200040101, DOI 10.1177/10883576050200040101]
Hollway JA, 2011, RES DEV DISABIL, V32, P1399, DOI 10.1016/j.ridd.2011.04.001
Honomichl RD, 2002, CHILD PSYCHIAT HUM D, V33, P107, DOI 10.1023/A:1020778108068
Inanuma K., 1984, JAPANESE J CHILD ADO, V25, P205
Ivanenko A, 2009, CHILD ADOL PSYCH CL, V18, P839, DOI 10.1016/j.chc.2009.04.005
Johnson C. R., 1996, SLEEP DISORDERS, V5, P673
Kulman G, 2000, NEUROENDOCRINOL LETT, V21, P31
Mayes SD, 2009, RES AUTISM SPECT DIS, V3, P931, DOI 10.1016/j.rasd.2009.04.002
Miller VA, 2003, HEADACHE, V43, P362, DOI 10.1046/j.1526-4610.2003.03071.x
Nir I, 1995, J AUTISM DEV DISORD, V25, P641, DOI 10.1007/BF02178193
Owens Judith A, 2005, Behav Sleep Med, V3, P18, DOI 10.1207/s15402010bsm0301_4
Owens JA, 2000, SLEEP, V23, P1043
Patzold LM, 1998, J PAEDIATR CHILD H, V34, P528
Richdale A., 2001, SLEEP DISTURBANCE CH, P181
RICHDALE AL, 1995, EUR CHILD ADOLES PSY, V4, P175
Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
Schreck KA, 2004, RES DEV DISABIL, V25, P57, DOI 10.1016/j.ridd.2003.04.007
Schreck KA, 2000, J AUTISM DEV DISORD, V30, P127, DOI 10.1023/A:1005407622050
Seifer R., 1996, INT C INF STUD PROV
Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
Sivertsen B, 2012, AUTISM, V16, P139, DOI 10.1177/1362361311404255
Souders MC, 2009, SLEEP, V32, P1566
Stores G, 1998, AUTISM, V2, P157, DOI 10.1177/1362361398022004
Tordjman S, 2005, BIOL PSYCHIAT, V57, P134, DOI 10.1016/j.biopsych.2004.11.003
Wiggs L, 2004, DEV MED CHILD NEUROL, V46, P372
Williams PG, 2004, J SLEEP RES, V13, P265
NR 44
TC 5
Z9 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1631
EP 1638
DI 10.1016/j.ridd.2014.03.037
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500020
PM 24780146
ER
PT J
AU Samadi, SA
McConkey, R
Bunting, B
AF Samadi, Sayyed Ali
McConkey, Roy
Bunting, Brendan
TI Parental wellbeing of Iranian families with children who have
developmental disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Intellectual disability; Autism spectrum disorder; Iran; Parents;
Health; Stress; Family functioning
ID AUTISM SPECTRUM DISORDERS; BEHAVIOR PROBLEMS; YOUNG-CHILDREN;
INTELLECTUAL DISABILITIES; DOWN-SYNDROME; STRESS; MOTHERS; IMPACT;
SUPPORT; ADJUSTMENT
AB To date, most research with families who have a child with developmental disabilities has been undertaken in English speaking countries. Poorer health, allied with increased levels of stress has been commonly reported for mothers but less is known about the impact on fathers and on overall family functioning. This study aimed to document the correlates of these parental impacts with Iranian mothers and fathers who had children with either intellectual disabilities (ID) or with autism spectrum disorders (ASD). In all 121 parents (69 mothers and 52 fathers from 94 families) who had a child with a diagnosis of ADS, along with 115 parents of children with ID (83 mothers and 32 fathers from 101 families) volunteered to take part in the study. Each participant completed through interview standardised rating scales of parenting stress, emotional well-being, family functioning and satisfaction with caring role along with demographic information and details of informal supports. Structural Equation Modeling identified that family functioning was much poorer in families whose child had ASD and both mothers and fathers reported higher levels of stress. Poorer emotional well-being contributed to higher stress and was more frequent among mothers, single parents and those whose children had behaviour problems. Having other dependents living at home and more sources of informal support improved the emotional wellbeing of parents but not their stress or family functioning. Parents who derived greater satisfaction from their caring role tended to have better emotional health and less stress. Although the impact on Iranian parents of having a child with developmental disabilities is broadly similar to those of parents in other cultures, there are indications that children with ASD present distinct challenges to these families. The model derived in this study is a useful guide both for further research as well as family-centred interventions. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Samadi, Sayyed Ali; McConkey, Roy] Univ Ulster, Inst Nursing & Hlth Res, Coleraine BT52 1SA, Londonderry, North Ireland.
[Bunting, Brendan] Univ Ulster, Psychol Res Inst, Coleraine BT52 1SA, Londonderry, North Ireland.
RP McConkey, R (reprint author), Univ Ulster, Inst Nursing & Hlth Res, Coleraine BT52 1SA, Londonderry, North Ireland.
EM r.mcconkey@ulster.ac.uk
CR Abidin R., 1990, PARENTAL STRESS INDE
Azar M, 2010, J PEDIATR NURS, V25, P46, DOI 10.1016/j.pedn.2008.11.001
Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
Bilgin Hulya, 2010, J Child Adolesc Psychiatr Nurs, V23, P92, DOI 10.1111/j.1744-6171.2010.00228.x
Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2
Boyd B. A., 2002, FOCUS AUTISM OTHER D, V17, P208, DOI DOI 10.1177/10883576020170040301
Crabtree SA, 2007, DISABIL SOC, V22, P49, DOI 10.1080/09687590601056618
Dababnah S, 2013, CHILD YOUTH SERV REV, V35, P1670, DOI 10.1016/j.childyouth.2013.07.007
Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
Davis N. O., 2008, J AUTISM DEV DISORD, V38, P278
Dempsey I, 2009, RES DEV DISABIL, V30, P558, DOI 10.1016/j.ridd.2008.08.005
Duvdevany I, 2003, J INTELL DISABIL RES, V47, P264, DOI 10.1046/j.1365-2788.2003.00488.x
Dyches TT, 2004, J AUTISM DEV DISORD, V34, P211, DOI 10.1023/B:JADD.0000022611.80478.73
EPSTEIN NB, 1983, J MARITAL FAM THER, V9, P171, DOI 10.1111/j.1752-0606.1983.tb01497.x
Fairthorne J., 2013, PREEXISTING DIFFEREN
Gau SSF, 2012, RES AUTISM SPECT DIS, V6, P263, DOI 10.1016/j.rasd.2011.05.007
Ghosh S, 2009, INT REV RES MENT RET, V37, P179, DOI 10.1016/S0074-7750(09)37006-8
Goldberg D., 1991, USERS GUIDE GEN HLTH
Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
Hastings RP, 2002, AM J MENT RETARD, V107, P116, DOI 10.1352/0895-8017(2002)107<0116:PPIFOC>2.0.CO;2
Homan A., 1998, NORMALIZING GEN HLTH
Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017
Jones L, 2013, J AUTISM DEV DISORD, V43, P2090, DOI 10.1007/s10803-012-1756-9
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
McConkey R, 2008, INT J NURS STUD, V45, P65, DOI 10.1016/j.ijnurstu.2006.08.007
McConkey R, 2013, DISABIL REHABIL, V35, P775, DOI 10.3109/09638288.2012.707744
Mori K, 2009, PEDIATR INT, V51, P364, DOI 10.1111/j.1442-200X.2008.02728.x
Muthen L. K., 1998, MPLUS USERS GUIDE
Norizan A, 2010, J INTELL DISABIL RES, V54, P992, DOI 10.1111/j.1365-2788.2010.01324.x
Ogston PL, 2011, RES AUTISM SPECT DIS, V5, P1378, DOI 10.1016/j.rasd.2011.01.020
Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
Pisula E., 2011, COMPREHENSIVE BOOK A
Rimmerman A, 2003, J INTELLECT DEV DIS, V28, P188, DOI 10.1080/1366825031000147111
Samadi S., 2011, AUTISM RES TREATMENT, DOI DOI 10.1155/2011/145359
Samadi SA, 2008, J POLICY PRACT INTEL, V5, P129, DOI 10.1111/j.1741-1130.2008.00160.x
Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
Special Interest Research Group of IASSIDD, 2013, J APPL RES INTELLECT
Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
Totsika V, 2013, AUTISM RES, V6, P201, DOI 10.1002/aur.1279
Welterlin A, 2007, DISABIL SOC, V22, P747, DOI 10.1080/09687590701659600
NR 42
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1639
EP 1647
DI 10.1016/j.ridd.2014.04.001
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500021
PM 24814475
ER
PT J
AU Gadow, KD
Pinsonneault, JK
Perlman, G
Sadee, W
AF Gadow, Kenneth D.
Pinsonneault, Julia K.
Perlman, Greg
Sadee, Wolfgang
TI Association of dopamine gene variants, emotion dysregulation and ADHD in
autism spectrum disorder
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Autism spectrum disorder; Depression; Emotion dysregulation;
ADHD; DAT1; DRD2
ID DEFICIT HYPERACTIVITY DISORDER; CHILD SYMPTOM INVENTORY-4; SCORING
ALGORITHMS; NUCLEUS-ACCUMBENS; CLINICAL UTILITY; DEPRESSION; EXPRESSION;
ANXIETY; SAMPLES; SYSTEM
AB The aim of the present study was to evaluate the association of dopaminergic gene variants with emotion dysregulation (EMD) and attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD). Three dopamine transporter gene (SLC6A3/DAT1)polymorphisms (intron8 5/6 VNTR, 3'-UTR 9/10 VNTR, rs27072 in the 3'-UTR) and one dopamine D2 receptor gene (DRD2) variant (rs2283265) were selected for genotyping based on a priori evidence of regulatory activity or, in the case of DAT1 9/10 VNTR, commonly reported associations with ADHD. A sample of 110 children with ASD Was assessed with a rigorously validated DSM-IV-referenced rating scale. Global EMD severity (parents' ratings) was associated with DAT1 intron8 (eta p(2)=.063) and rs2283265 (eta p(2)=.044). Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (eta p(2)=.065) and depression (eta p(2)=.059), and for DRD2 rs2283265, depression (eta p(2)=.053). DRD2 rs2283265 was associated with teachers' global ratings of ADHD (eta p(2) =.052). DAT1 intron8 was associated with parent-rated hyperactivity (eta p(2) =.045) and both DAT1 9/10 VNTR (eta p(2)=.105) and DRD2 rs2283265 (eta p(2)=.069) were associated with teacher-rated inattention. These findings suggest that dopaminergic gene polymorphisms may modulate EMD and ADHD symptoms in children with ASD but require replication with larger independent samples. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Gadow, Kenneth D.; Perlman, Greg] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA.
[Pinsonneault, Julia K.; Sadee, Wolfgang] Ohio State Univ, Wexner Med Ctr, Ctr Pharmacogen, Dept Pharmacol, Columbus, OH 43210 USA.
RP Gadow, KD (reprint author), SUNY Stony Brook, Dept Psychiat, Putnam Hall, Stony Brook, NY 11794 USA.
EM kenneth.gadow@stonybrook.edu; pinsonneault.2@osu.edu;
gperlman@gmail.com; Wolfgang.Sadee@osumc.edu
CR Alcaro A, 2007, BRAIN RES REV, V56, P283, DOI 10.1016/j.brainresrev.2007.07.014
Badgaiyan RD, 2009, NEUROIMAGE, V47, P2041, DOI 10.1016/j.neuroimage.2009.06.008
Beiderbeck DI, 2012, PSYCHONEUROENDOCRINO, V37, P1969, DOI 10.1016/j.psyneuen.2012.04.011
Belsky J, 2009, MOL PSYCHIATR, V14, P746, DOI 10.1038/mp.2009.44
Cohen IL, 2011, CLIN GENET, V79, P355, DOI 10.1111/j.1399-0004.2010.01471.x
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
DeVincent CJ, 2009, AUTISM RES, V2, P312, DOI 10.1002/aur.106
Felten A, 2011, BRAIN BEHAV, V1, P109, DOI 10.1002/brb3.20
Gadow K. D., 2008, ADOLESCENT SYMPTOM I
Gadow K. D., 2002, CHILD SYMPTOM INVENT
Gadow K. D., 2014, COGNITIVE B IN PRESS
Gadow K. D., 1997, EARLY CHILDHOOD INVE
Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gadow KD, 2012, J AUTISM DEV DISORD, V42, P1353, DOI 10.1007/s10803-011-1367-x
Gadow KD, 2011, SYMPTOM INVENTORIES
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P419, DOI 10.1007/s10803-007-0408-y
Gadow KD, 2012, J ABNORM CHILD PSYCH, V40, P1073, DOI 10.1007/s10802-012-9637-4
Gadow KD, 2013, PROG NEURO-PSYCHOPH, V40, P292, DOI 10.1016/j.pnpbp.2012.10.019
Garcia-Garcia M, 2010, NEUROPSYCHOLOGIA, V48, P1483, DOI 10.1016/j.neuropsychologia.2010.01.018
Gizer IR, 2009, HUM GENET, V126, P51, DOI 10.1007/s00439-009-0694-x
Guerini F. R., 2011, PHARM RES, V64, P83
Guttmann-Steinmetz S, 2009, J AUTISM DEV DISORD, V39, P976, DOI 10.1007/s10803-009-0706-7
Guttmann-Steinmetz S, 2010, J AUTISM DEV DISORD, V40, P1006, DOI 10.1007/s10803-010-0950-x
Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA
Kaat AJ, 2013, J ABNORM CHILD PSYCH, V41, P959, DOI 10.1007/s10802-013-9739-7
Klimek V, 2002, BIOL PSYCHIAT, V52, P740, DOI 10.1016/S0006-3223(02)01383-5
Kuepper Y, 2012, GENES BRAIN BEHAV, V11, P643, DOI 10.1111/j.1601-183X.2012.00783.x
Lecavalier L, 2009, J AUTISM DEV DISORD, V39, P278, DOI 10.1007/s10803-008-0622-2
Levita L, 2002, BEHAV BRAIN RES, V137, P115, DOI 10.1016/S0166-4328(02)00287-5
LEVY F, 1991, AUST NZ J PSYCHIAT, V25, P277, DOI 10.3109/00048679109077746
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Meyer JH, 2001, NEUROREPORT, V12, P4121, DOI 10.1097/00001756-200112210-00052
Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
Moyer RA, 2011, NEUROPSYCHOPHARMACOL, V36, P753, DOI 10.1038/npp.2010.208
Opmeer EM, 2010, PROG NEUROBIOL, V92, P112, DOI 10.1016/j.pneurobio.2010.06.003
Pinsonneault JK, 2011, NEUROPSYCHOPHARMACOL, V36, P1644, DOI 10.1038/npp.2011.45
Roohi J, 2009, J AUTISM DEV DISORD, V39, P67, DOI 10.1007/s10803-008-0600-8
ROY A, 1992, ARCH GEN PSYCHIAT, V49, P447
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Salgado-Pineda P, 2005, CLIN NEUROPHARMACOL, V28, P228, DOI 10.1097/01.wnf.0000185824.57690.f0
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Sullivan D, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2012.146
Wender P, 1971, MINIMAL BRAIN DYSFUN
Zhang Y, 2007, P NATL ACAD SCI USA, V104, P20552, DOI 10.1073/pnas.0707106104
NR 47
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1658
EP 1665
DI 10.1016/j.ridd.2014.04.007
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500023
PM 24780147
ER
PT J
AU Li, XM
Wang, K
Wu, JX
Hong, YF
Zhao, JP
Feng, XJ
Xu, M
Wang, M
Ndasauka, Y
Zhang, XC
AF Li, Xiaoming
Wang, Kai
Wu, Jianxian
Hong, Yongfeng
Zhao, Jingpu
Feng, Xiaojun
Xu, Mei
Wang, Min
Ndasauka, Yamikani
Zhang, Xiaochu
TI The link between impaired theory of mind and executive function in
children with cerebral palsy
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Cerebral palsy; Theory of mind; Executive function
ID AUTISM SPECTRUM DISORDERS; LATENT VARIABLE ANALYSIS; WORKING-MEMORY;
ASPERGER-SYNDROME; PERFORMANCE; BELIEFS; SCHIZOPHRENIA; COMPREHENSION;
PRESCHOOLERS; DISABILITIES
AB The aim of the study was to explore the relationship between theory of mind (ToM) deficits and executive function (EF) impairments in children with cerebral palsy (CP), 42 CP with children and 42 typically developing (TD) children, acting as controls, were assessed on the tasks of ToM (false belief and faux pas) and EF (inhibition, updating and shifting). Results showed that CP children had deficits both in ToM and EF tasks. The correlation analyses showed that two EF components (inhibition and updating) were strongly related to false belief and faux pas in both two groups. We also found correlation between shifting and false belief and faux pas. However, this correlation was only found in TD children and not in children with CP. These findings suggest that children with CP lag behind TD children in both ToM and EF. Further, the results reveal, interestingly, that ToM deficits in CP children might be related to their inhibition and updating impairments, but not to shifting impairments. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Li, Xiaoming; Zhang, Xiaochu] Univ Sci & Technol China, CAS Key Lab Brain Funct & Dis, Hefei 230027, Anhui Province, Peoples R China.
[Li, Xiaoming; Zhang, Xiaochu] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui Province, Peoples R China.
[Li, Xiaoming; Wang, Kai] Anhui Med Univ, Dept Med Psychol, Hefei 230032, Anhui Province, Peoples R China.
[Wu, Jianxian; Hong, Yongfeng; Zhao, Jingpu; Feng, Xiaojun; Xu, Mei] Anhui Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Hefei 230032, Anhui Province, Peoples R China.
[Wang, Min] Anhui Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Hefei 230032, Anhui Province, Peoples R China.
[Ndasauka, Yamikani; Zhang, Xiaochu] Univ Sci & Technol China, Sch Humanities & Social Sci, Hefei 230026, Anhui, Peoples R China.
RP Li, XM (reprint author), Univ Sci & Technol China, CAS Key Lab Brain Funct & Dis, Hefei 230027, Anhui Province, Peoples R China.
EM psyxiaoming@126.com; zxcustc@ustc.edu.cn
RI Zhang, Xiaochu/O-9592-2014
OI Zhang, Xiaochu/0000-0002-7541-0130
CR Abbeduto L, 2004, J INTELL DISABIL RES, V48, P150, DOI 10.1111/j.1365-2788.2004.00524.x
Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
Bottcher L, 2010, CHILD NEUROPSYCHOL, V16, P209, DOI 10.1080/09297040903559630
Brocki KC, 2006, INFANT CHILD DEV, V15, P19, DOI 10.1002/icd.413
Brydges CR, 2012, INTELLIGENCE, V40, P458, DOI 10.1016/j.intell.2012.05.006
Bull R, 2008, COGNITION, V107, P663, DOI 10.1016/j.cognition.2007.07.015
Caillies S, 2012, RES DEV DISABIL, V33, P1380, DOI 10.1016/j.ridd.2012.03.012
Carroll DJ, 2012, J EXP CHILD PSYCHOL, V112, P312, DOI 10.1016/j.jecp.2012.03.001
Christ SE, 2003, NEUROPSYCHOLOGY, V17, P171, DOI 10.1037/0894-4105.17.1.171
Cornish K, 2005, J INTELL DISABIL RES, V49, P372, DOI 10.1111/j.1365-2788.2005.00678.x
Courtin C, 2005, DEVELOPMENTAL SCI, V8, P16, DOI 10.1111/j.1467-7687.2005.00389.x
Dahlgren S, 2010, RES DEV DISABIL, V31, P617, DOI 10.1016/j.ridd.2009.12.010
Dahlgren S, 2003, EUR J COGN PSYCHOL, V15, P129, DOI 10.1080/09541440244000030
Englander ZA, 2013, NEUROIMAGE-CLIN, V2, P440, DOI 10.1016/j.nicl.2013.03.006
Ettenhofer ML, 2006, NEUROPSYCHOLOGY, V20, P607, DOI 10.1037/0894-4105.20.5.607
Falkman K. W., 2005, INT J DISABIL DEV ED, V52, P139, DOI 10.1080/10349120500086397
Garon N, 2008, PSYCHOL BULL, V134, P31, DOI 10.1037/0033-2909.134.1.31
GERSTADT CL, 1994, COGNITION, V53, P129, DOI 10.1016/0010-0277(94)90068-X
Gong Y. X., 1993, WECHSLER INTELLIGENC
Greig TC, 2004, J NERV MENT DIS, V192, P12, DOI 10.1097/01.nmd.0000105995.67947.fc
Henning A, 2011, J EXP CHILD PSYCHOL, V108, P513, DOI 10.1016/j.jecp.2010.10.006
Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
Jenks KM, 2009, J CHILD PSYCHOL PSYC, V50, P824, DOI 10.1111/j.1469-7610.2008.02031.x
Jersild A. T., 1927, ARCH PSYCHOL, V14, P81
Kimberg DY, 1997, CURR DIR PSYCHOL SCI, V6, P185, DOI 10.1111/1467-8721.ep10772959
Leslie AM, 2005, COGNITIVE PSYCHOL, V50, P45, DOI 10.1016/j.cogpsych.2004.06.002
Li XM, 2013, INT J PSYCHOL, V48, P715, DOI 10.1080/00207594.2012.673724
Li ZH, 2004, NEUROIMAGE, V21, P181, DOI 10.1016/j.neuroimage.2003.08.043
Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018
Meristo M, 2012, DEVELOPMENTAL SCI, V15, P633, DOI 10.1111/j.1467-7687.2012.01155.x
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
MORRIS N, 1990, BRIT J PSYCHOL, V81, P111
Muller U, 2012, J EXP CHILD PSYCHOL, V111, P331, DOI 10.1016/j.jecp.2011.08.014
Nadeau L, 2008, DEV NEUROREHABIL, V11, P134, DOI 10.1080/17518420701688607
Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
Pennington L, 2001, INT J LANG COMM DIS, V36, P371
Perner R. W. J., 1985, J EXPT CHILD PSYCHOL, V39, P437
Peron J, 2009, NEUROPSYCHOLOGIA, V47, P406, DOI 10.1016/j.neuropsychologia.2008.09.008
Phillips LH, 2011, COGNITION, V120, P236, DOI 10.1016/j.cognition.2011.05.003
Raven J. C., 1986, RAVENS PROGR MATRICE
Rosenbaum P, 2007, DEV MED CHILD NEUROL, V49, P8
Rothmayr C, 2011, NEUROIMAGE, V56, P1705, DOI 10.1016/j.neuroimage.2010.12.052
Schenkel LS, 2005, J PSYCHIAT RES, V39, P499, DOI 10.1016/j.jpsychires.2005.01.001
Schneider D, 2013, COGNITION, V129, P410, DOI 10.1016/j.cognition.2013.08.004
Shamay-Tsoory SG, 2007, NEUROPSYCHOLOGIA, V45, P3054, DOI 10.1016/j.neuropsychologia.2007.05.021
St Clair-Thompson HL, 2006, Q J EXP PSYCHOL, V59, P745, DOI 10.1080/17470210500162854
SULLIVAN K, 1994, DEV PSYCHOL, V30, P395, DOI 10.1037//0012-1649.30.3.395
Sylvester CYC, 2003, NEUROPSYCHOLOGIA, V41, P357, DOI 10.1016/S0028-3932(02)00167-7
Tager-Flusberg H, 2000, COGNITION, V76, P59, DOI 10.1016/S0010-0277(00)00069-X
Tajmirriyahi M, 2013, RES AUTISM SPECT DIS, V7, P1543, DOI 10.1016/j.rasd.2013.08.007
Thirion-Marissiaux AF, 2008, RES DEV DISABIL, V29, P547, DOI 10.1016/j.ridd.2007.09.004
Voorman JM, 2010, DEV MED CHILD NEUROL, V52, P441, DOI 10.1111/j.1469-8749.2009.03399.x
Warschausky S, 2003, REHABIL PSYCHOL, V48, P250, DOI 10.1037/0090-5550.48.4.250
WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
NR 56
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1686
EP 1693
DI 10.1016/j.ridd.2014.03.017
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500026
PM 24685096
ER
PT J
AU Machalicek, W
McDuffie, A
Oakes, A
Ma, M
Thurman, AJ
Rispoli, MJ
Abbeduto, L
AF Machalicek, Wendy
McDuffie, Andrea
Oakes, Ashley
Ma, Monica
Thurman, Angela John
Rispoli, Mandy J.
Abbeduto, Leonard
TI Examining the operant function of challenging behavior in young males
with fragile X syndrome: A summary of 12 cases
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Challenging behavior; Fragile X syndrome; Functional analysis;
Functional behavior assessment
ID SELF-INJURIOUS-BEHAVIOR; AUTISM SPECTRUM DISORDERS; ABERRANT BEHAVIOR;
CHILDREN; INDIVIDUALS; PHENOTYPE; ATTENTION; TOPOGRAPHIES; DISABILITIES;
QUESTIONS
AB This study used experimental functional analyses to examine the operant function of challenging behaviors exhibited by 12 males (ages 27-51 months) with fragile X syndrome (FXS). Eight children met criteria for negatively reinforced challenging behavior in the form of escape from demands and/or escape from social interactions. Nine children met criteria for positively reinforced challenging behavior in the form of obtaining access to highly preferred items. Attention was identified as a maintaining consequence for three children. The functional analysis was inconclusive for one child. Results suggest that, for young males with FXS, challenging behaviors may more likely be tangibly and escape maintained than attention maintained. Our findings affirm past research suggesting a unique behavioral phenotype for this population. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Machalicek, Wendy] Univ Oregon, Eugene, OR 97403 USA.
[McDuffie, Andrea; Oakes, Ashley; Ma, Monica; Thurman, Angela John; Abbeduto, Leonard] Univ Calif Davis, MIND Inst, Davis, CA USA.
[Rispoli, Mandy J.] Texas A&M Univ, College Stn, TX 77843 USA.
RP Machalicek, W (reprint author), Univ Oregon, Dept Special Educ & Clin Sci, 901 East 18th Ave, Eugene, OR 97403 USA.
EM wmachali@uoregon.edu
CR ANDERSON L, 1978, J CONSULT CLIN PSYCH, V46, P529
Bailey DB, 2008, AM J MED GENET A, V146A, P2060, DOI 10.1002/ajmg.a.32439
Bailey DB, 1998, J AUTISM DEV DISORD, V28, P499
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
BAUMGARDNER TL, 1995, PEDIATRICS, V95, P744
BREGMAN JD, 1988, J AUTISM DEV DISORD, V18, P343, DOI 10.1007/BF02212191
COHEN IL, 1988, AM J MENT RETARD, V92, P436
Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
Cornish K, 2007, CORTEX, V43, P672, DOI 10.1016/S0010-9452(08)70497-0
Crawford DC, 2001, GENET MED, V3, P359, DOI 10.1097/00125817-200109000-00006
Crnic K, 2004, INFANT YOUNG CHILD, V17, P223
Demark JL, 2003, AM J MENT RETARD, V108, P314, DOI 10.1352/0895-8017(2003)108<314:BRBAAF>2.0.CO;2
DERBY KM, 1994, J APPL BEHAV ANAL, V27, P267, DOI 10.1901/jaba.1994.27-267
DERBY KM, 1992, J APPL BEHAV ANAL, V25, P713, DOI 10.1901/jaba.1992.25-713
Derby KM, 2000, J APPL BEHAV ANAL, V33, P113, DOI 10.1901/jaba.2000.33-113
Gast D. L., 2010, SINGLE SUBJECT RES M
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Hagerman R. J., 2002, FRAGILE X SYNDROME D
HAGERMAN RJ, 1986, AM J MED GENET, V23, P241, DOI 10.1002/ajmg.1320230119
Hagopian LP, 2001, J APPL BEHAV ANAL, V34, P229, DOI 10.1901/jaba.2001.34-229
Hagopian LP, 1997, J APPL BEHAV ANAL, V30, P313, DOI 10.1901/jaba.1997.30-313
Hall S, 2001, DEV MED CHILD NEUROL, V43, P745, DOI 10.1017/S0012162201001360
Hall S, 2006, J AUTISM DEV DISORD, V36, P935, DOI 10.1007/s10803-006-0132-z
Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
Hall SS, 2008, AM J MENT RETARD, V113, P44, DOI 10.1352/0895-8017(2008)113[44:CSAABI]2.0.CO;2
Hanley GP, 2003, J APPL BEHAV ANAL, V36, P147, DOI 10.1901/jaba.2003.36-147
Harris SW, 2008, AM J MENT RETARD, V113, P427, DOI 10.1352/2008.113:427-438
Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286
Healy O, 2013, RES AUTISM SPECT DIS, V7, P66, DOI 10.1016/j.rasd.2012.05.006
Hus V., 2013, J AUTISM DEV DISORDE
Iwata Brian A, 2008, Behav Anal Pract, V1, P3
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Kahng SW, 1999, J APPL BEHAV ANAL, V32, P149, DOI 10.1901/jaba.1999.32-149
Kau A. S. M., 2000, AM J MENT RETARD, V105, P266
Langthorne P, 2011, AJIDD-AM J INTELLECT, V116, P65, DOI 10.1352/1944-7558-116.1.65
Langthorne P., 2012, J AUTISM DEV DISORD, V16, P65
Leigh M. J., 2012, NEURODEVELOPMENTAL D
Lesniak-Karpiak K, 2003, J AUTISM DEV DISORD, V33, P55, DOI 10.1023/A:1022230504787
Lewis P, 2006, J INTELL DISABIL RES, V50, P532, DOI 10.1111/j.1365-2788.2006.00803.x
Lohrmann-O'Rourke S, 1998, AM J MENT RETARD, V103, P146, DOI 10.1352/0895-8017(1998)103<0146:EBMTAT>2.0.CO;2
Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
Love JR, 2009, J AUTISM DEV DISORD, V39, P363, DOI 10.1007/s10803-008-0633-z
Martin NT, 1999, RES DEV DISABIL, V20, P125, DOI 10.1016/S0891-4222(98)00037-7
Matson J. L., 1995, USERS GUIDE QUESTION
McWilliam R. A., 2003, RBI REPORT FORM
Mullen E, 1995, MULLEN SCALES EARLY
NORTHUP J, 1991, J APPL BEHAV ANAL, V24, P509, DOI 10.1901/jaba.1991.24-509
O'Neill R. E., 1997, FUNCTIONAL ASSESSMEN, V2nd
OLIVER C, 1993, J AUTISM DEV DISORD, V23, P91, DOI 10.1007/BF01066421
O'Reilly MF, 2006, J APPL BEHAV ANAL, V39, P239, DOI 10.1901/jaba.2006.160-04
Sabaratnam M., 2003, EUROPEAN CHILD ADOLE, V12, P171
Scerif G, 2012, J CHILD PSYCHOL PSYC, V53, P641, DOI 10.1111/j.1469-7610.2011.02515.x
Sloneem J, 2009, J INTELL DISABIL RES, V53, P590, DOI 10.1111/j.1365-2788.2009.01183.x
Smith LE, 2012, AJIDD-AM J INTELLECT, V117, P1, DOI 10.1352/1944-7558-117.1.1
Symons FJ, 2003, AM J MED GENET A, V118A, P115, DOI 10.1002/ajmg.a.10078
Symons FJ, 2010, AJIDD-AM J INTELLECT, V115, P473, DOI [10.1352/1944-7558-115.6.473, 10.1352/194475581156473]
TAYLOR AK, 1994, JAMA-J AM MED ASSOC, V271, P507, DOI 10.1001/jama.271.7.507
Taylor L, 2008, J INTELL DISABIL RES, V52, P830, DOI 10.1111/j.1365-2788.2008.01066.x
Turk J, 1998, J APPL RES INTELLECT, V11, P175
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
WACKER DP, 1994, J APPL BEHAV ANAL, V27, P405, DOI 10.1901/jaba.1994.27-405
Watkins N, 2013, RES DEV DISABIL, V34, P11, DOI 10.1016/j.ridd.2012.08.003
Williams JR, 2008, B WORLD HEALTH ORGAN, V86, P650, DOI 10.2471/BLT.08.050955
Woodcock K, 2009, J INTELL DISABIL RES, V53, P265, DOI 10.1111/j.1365-2788.2008.01122.x
Zimmerman I. L., 2011, PRESCHOOL LANGUAGE S
NR 65
TC 2
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1694
EP 1704
DI 10.1016/j.ridd.2014.03.014
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500027
PM 24679547
ER
PT J
AU Greer, J
Hamiliton, C
Riby, DM
Riby, LM
AF Greer, Joanna
Hamiliton, Colin
Riby, Deborah M.
Riby, Leigh M.
TI Deeper processing is beneficial during episodic memory encoding for
adults with Williams syndrome
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Williams Syndrome; Ageing; Cognition; Episodic memory; Semantic memory;
Depths of processing; Encoding
ID LONG-TERM-MEMORY; AGE-DIFFERENCES; DOWN-SYNDROME; OLDER-ADULTS;
RECOLLECTION; FAMILIARITY; TASK; INDIVIDUALS; RECOGNITION; PERFORMANCE
AB Previous research exploring declarative memory in Williams syndrome (WS) has revealed impairment in the processing of episodic information accompanied by a relative strength in semantic ability. The aim of the current study was to extend this literature by examining how relatively spared semantic memory may support episodic remembering. Using a level of processing paradigm, older adults with WS (aged 35-61 years) were compared to typical adults of the same chronological age and typically developing children matched for verbal ability. In the study phase, pictures were encoded using either a deep (decide if a picture belongs to a particular category) or shallow (perceptual based processing) memory strategy. Behavioural indices (reaction time and accuracy) at retrieval were suggestive of an overall difficulty in episodic memory for WS adults. Interestingly, however, semantic support was evident with a greater recall of items encoded with deep compared to shallow processing, indicative of an ability to employ semantic encoding strategies to maximise the strength of the memory trace created. Unlike individuals with autism who find semantic elaboration strategies problematic, the pattern of findings reported here suggests in those domains that are relatively impaired in WS, support can be recruited from relatively spared cognitive processes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Greer, Joanna; Hamiliton, Colin; Riby, Leigh M.] Northumbria Univ, Dept Psychol, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England.
[Riby, Deborah M.] Univ Durham, Dept Psychol, Durham DH1 3HP, England.
RP Riby, LM (reprint author), Northumbria Univ, Dept Psychol, Northumberland Bldg, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England.
EM leigh.riby@northumbria.ac.uk
CR BELLEZZA FS, 1981, REV EDUC RES, V51, P247, DOI 10.3102/00346543051002247
Brock J, 2007, DEV PSYCHOPATHOL, V19, P97, DOI 10.1017/S095457940707006X
Broman S., 1994, ATYPICAL COGNITIVE D
Costanzo F, 2013, CORTEX, V49, P232, DOI 10.1016/j.cortex.2011.06.007
CRAIK FIM, 1972, J VERB LEARN VERB BE, V11, P671, DOI 10.1016/S0022-5371(72)80001-X
Deruelle C, 2006, RES DEV DISABIL, V27, P243, DOI 10.1016/j.ridd.2005.03.002
Devenny DA, 2004, DEV NEUROPSYCHOL, V26, P691, DOI 10.1207/s15326942dn2603_3
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Gallo DA, 2004, J EXP PSYCHOL LEARN, V30, P120, DOI 10.1037/0278-7393.30.1.120
Gardiner JM, 2006, COGN NEUROPSYCHOL, V23, P930, DOI 10.1080/02643290600588442
Grady CL, 2000, CURR OPIN NEUROBIOL, V10, P224, DOI 10.1016/S0959-4388(00)00073-8
Greer J, 2013, RES DEV DISABIL, V34, P4170, DOI 10.1016/j.ridd.2013.08.041
Jarrold C, 2007, CORTEX, V43, P233, DOI 10.1016/S0010-9452(08)70478-7
Jarrold C., 2000, COGNITIVE NEUROPSYCH, V5, P293
Luo L, 2007, PSYCHOL AGING, V22, P269, DOI 10.1037/0882-7974.22.2.269
Meyer-Lindenberg A., 2006, NATURE REV NEUROSCIE, V7, P389
Meyer-Lindenberg A, 2005, J CLIN INVEST, V115, P1888, DOI 10.1172/JCI24892
Morris CA, 2000, ANNU REV GENOM HUM G, V1, P461
Naveh-Benjamin M, 2000, J EXP PSYCHOL LEARN, V26, P1170, DOI 10.1037//0278-7393.26.2.1170
Pennington BF, 2003, CHILD DEV, V74, P75, DOI 10.1111/1467-8624.00522
Rhodes SM, 2011, J CLIN EXP NEUROPSYC, V33, P147, DOI 10.1080/13803395.2010.495057
Rhodes SM, 2010, NEUROPSYCHOLOGIA, V48, P1216, DOI 10.1016/j.neuropsychologia.2009.12.021
Riby LA, 2004, Q J EXP PSYCHOL-A, V57, P241, DOI 10.1080/02724980343000206
Searcy YM, 2004, AM J MENT RETARD, V109, P231, DOI 10.1352/0895-8017(2004)109<231:TRBAAI>2.0.CO;2
Smith AD, 2009, PERCEPTION, V38, P694, DOI 10.1068/p6050
SNODGRASS JG, 1980, J EXP PSYCHOL-HUM L, V6, P174, DOI 10.1037/0278-7393.6.2.174
Thomas MSC, 2006, LANG COGNITIVE PROC, V21, P721, DOI 10.1080/01690960500258528
Toichi M, 2002, NEUROPSYCHOLOGIA, V40, P964, DOI 10.1016/S0028-3932(01)00163-4
Troyer AK, 2006, J GERONTOL B-PSYCHOL, V61, pP67
Tyler LK, 1997, CORTEX, V33, P515, DOI 10.1016/S0010-9452(08)70233-8
UDWIN O, 1987, J CHILD PSYCHOL PSYC, V28, P297, DOI 10.1111/j.1469-7610.1987.tb00212.x
Vicari S, 2005, DEV MED CHILD NEUROL, V47, P305, DOI 10.1017/S0012162205000599
Yonelinas AP, 2002, J MEM LANG, V46, P441, DOI 10.1006/jmla.2002.2864
NR 33
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1720
EP 1726
DI 10.1016/j.ridd.2014.03.004
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500030
PM 24679545
ER
PT J
AU Mertz, LGB
Thaulov, P
Trillingsgaard, A
Christensen, R
Vogel, I
Hertz, JM
Ostergaard, JR
AF Mertz, Line Granild Bie
Thaulov, Per
Trillingsgaard, Anegen
Christensen, Rikke
Vogel, Ida
Hertz, Jens Michael
Ostergaard, John R.
TI Neurodevelopmental outcome in Angelman syndrome: Genotype-phenotype
correlations
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Angelman syndrome; 15q11.2-q13; Language skills; Autism; ADDS; Mullen;
Intellectual disability
ID AUTISM SPECTRUM DISORDERS; DISTINCT PHENOTYPES; DELETION; DIAGNOSIS;
FEATURES
AB Angelman syndrome (AS) is a neurogenetic disorder characterized by intellectual disability, developmental delay, lack of speech, and epileptic seizures. Previous studies have indicated that children with AS due to 15q11.2-q13 deletions have a more severe developmental delay and present more often autistic features than those with AS caused by other genetic etiologies. The present study investigated the neurodevelopmental profiles of the different genetic etiologies of AS, and examined the evolution of mental development and autistic features over a 12-year period in children with a 15q11.2-q13 deletion. This study included 42 children with AS. Twelve had a Class I deletion, 18 had Class II deletions, three showed atypical large deletions, five had paternal uniparental disomy (pUPD) and four had UBE3A mutations. Children with a deletion (Class I and Class II) showed significantly reduced developmental age in terms of visual perception, receptive language, and expressive language when compared to those with a UBE3A mutation and pUPD. Within all subgroups, expressive language performance was significantly reduced when compared to the receptive performance. A follow-up study of seven AS cases with 15q11.2-q13 deletions revealed that over 12 years, the level of autistic features did not change, but both receptive and expressive language skills improved. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Mertz, Line Granild Bie; Ostergaard, John R.] Aarhus Univ Hosp, Dept Pediat, Ctr Rare Dis, Aarhus, Denmark.
[Thaulov, Per] Aarhus Univ Hosp, Psychiat Hosp Children & Adolescents, Aarhus, Denmark.
[Trillingsgaard, Anegen] Aarhus Univ, Dept Psychol, DK-8000 Aarhus C, Denmark.
[Christensen, Rikke; Vogel, Ida] Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark.
[Hertz, Jens Michael] Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.
RP Mertz, LGB (reprint author), Aarhus Univ Hosp, Dept Pediat, Ctr Rare Dis, Aarhus, Denmark.
EM linebiemertz@dadlnet.dk
CR Akshoomoff N, 2006, CHILD NEUROPSYCHOL, V12, P269, DOI 10.1080/09297040500473714
Andersen TF, 1999, DAN MED BULL, V46, P263
Bonati MT, 2007, NEUROGENETICS, V8, P169, DOI 10.1007/s10048-007-0086-0
Conant KD, 2009, EPILEPSIA, V50, P2497, DOI 10.1111/j.1528-1167.2009.02109.x
Gentile JK, 2010, J DEV BEHAV PEDIATR, V31, P592, DOI 10.1097/DBP.0b013e3181ee408e
Kim SJ, 2012, EUR J HUM GENET, V20, P283, DOI 10.1038/ejhg.2011.187
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lossie AC, 2001, J MED GENET, V38, P834, DOI 10.1136/jmg.38.12.834
Mertz LGB, 2013, AM J MED GENET A, V161, P2197, DOI 10.1002/ajmg.a.36058
Moss J, 2013, AJIDD-AM J INTELLECT, V118, P262, DOI 10.1352/1944-7558-118.4.262
Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
Mullen E, 1995, MULLEN SCALES EARLY
Oliver C, 2007, J CHILD PSYCHOL PSYC, V48, P571, DOI 10.1111/j.1469-7610.2007.01736.x
Peters SU, 2004, CLIN GENET, V66, P530, DOI 10.1111/j.1399-0004.2004.00362.x
Peters SU, 2012, J CHILD PSYCHOL PSYC, V53, P152, DOI 10.1111/j.1469-7610.2011.02455.x
Sahoo T, 2006, J MED GENET, V43, P512, DOI 10.1136/jmg.2005.036913
Sahoo T, 2007, EUR J HUM GENET, V15, P943, DOI 10.1038/sj.ejhg.5201859
Sahoo T, 2005, AM J MED GENET A, V139A, P106, DOI 10.1002/ajmg.a.31000
Tan WH, 2011, AM J MED GENET A, V155A, P81, DOI 10.1002/ajmg.a.33775
Trillingsgaard A, 2004, AUTISM, V8, P163, DOI 10.1177/1362361304042720
Varela MC, 2004, EUR J HUM GENET, V12, P987, DOI 10.1038/sj.ejhg.5201264
Williams CA, 2010, AM J MED GENET C, V154C, P432, DOI 10.1002/ajmg.c.30278
NR 22
TC 1
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1742
EP 1747
DI 10.1016/j.ridd.2014.02.018
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500033
PM 24656292
ER
PT J
AU Tureck, K
Matson, JL
Cervantes, P
Konst, MJ
AF Tureck, Kim
Matson, Johnny L.
Cervantes, Paige
Konst, Matthew J.
TI An examination of the relationship between autism spectrum disorder,
intellectual functioning, and comorbid symptoms in children
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Intellectual functioning; Comorbid symptoms;
Autism Spectrum Disorders-Comorbidity for; Children (ASD-CC)
ID PSYCHIATRIC-DISORDERS; PDD-NOS; CHALLENGING BEHAVIORS; REPETITIVE
BEHAVIORS; DIAGNOSTIC FIDELITY; ANXIETY SYMPTOMS; INFANT SCREEN; ASD-CC;
ADULTS; DEPRESSION
AB There is a deficiency of research looking at how rates of comorbid psychopathology are effected by autism spectrum disorder (ASD) and intellectual functioning level. The present study aimed to extend the literature in this area by evaluating how ASD and IQ scores are related to ratings on a measure of comorbid symptoms. Twenty-three children with ASD and 87 children without ASD participated in this study. Rates of tantrum behavior, avoidant behavior, worry/depressed, repetitive behavior, under-eating, over-eating, and conduct behavior were examined utilizing the Autism Spectrum Disorders-Comorbidity for Children (ASD-CC). Correlational and multiple regression analyses were then conducted. ASD diagnosis significantly predicted rates of tantrum behavior, avoidant behavior, and repetitive behavior. Children with ASD tended to have higher rates of all three of these comorbid symptoms than children without ASD. Although not statistically significant, there was a negative correlation between IQ and rates of comorbid symptoms, such that children with higher IQ scores tended to have lower rates of comorbid symptoms. The implications of these findings on assessment and intervention are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Tureck, Kim; Matson, Johnny L.; Cervantes, Paige; Konst, Matthew J.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Tureck, K (reprint author), LSU, Dept Psychol, Baton Rouge, LA 70803 USA.
EM kim.tureck@gmail.com
CR Adams HL, 2014, RES AUTISM SPECT DIS, V8, P193, DOI 10.1016/j.rasd.2013.11.008
[Anonymous], 2002, WISC 4 TECHN MAN 2
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Davis TE, 2010, RES AUTISM SPECT DIS, V4, P305, DOI 10.1016/j.rasd.2009.10.002
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Flanagan D., 2009, ESSENTIALS WISC 4 AS, VSecond
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348
Ghaziuddin M, 1998, J AUTISM DEV DISORD, V28, P111, DOI 10.1023/A:1026036514719
Goldin RL, 2013, RES DEV DISABIL, V34, P2669, DOI 10.1016/j.ridd.2013.04.022
Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9
Kaufman A. S., 2006, J PSYCHOEDUCATIONAL, V24, P278, DOI DOI 10.1177/0734282906288389
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
LoVullo SV, 2009, RES DEV DISABIL, V30, P1288, DOI 10.1016/j.ridd.2009.05.004
Matson J, 2008, J INTELLECT DEV DIS, V33, P323, DOI 10.1080/13668250802492600
Matson J, 2009, J MENT HEALTH RES IN, V2, P169, DOI 10.1080/19315860902725875
Matson J. L., 2007, AUTISM SPECTRUM DISO
Matson JL, 2008, RES DEV DISABIL, V29, P341, DOI 10.1016/j.ridd.2007.06.006
Matson JL, 2007, BEHAV MODIF, V31, P682, DOI 10.1177/0145445507301650
Matson JL, 2009, RES AUTISM SPECT DIS, V3, P924, DOI 10.1016/j.rasd.2009.04.001
Matson JL, 2009, RES DEV DISABIL, V30, P1317, DOI 10.1016/j.ridd.2009.05.008
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
Matson JL, 2009, RES AUTISM SPECT DIS, V3, P345, DOI 10.1016/j.rasd.2008.08.002
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
Matson JL, 2008, J DEV PHYS DISABIL, V20, P155, DOI 10.1007/s10882-007-9086-0
Matson JL, 2009, RES AUTISM SPECT DIS, V3, P196, DOI 10.1016/j.rasd.2008.05.005
Matson JL, 2010, DEV NEUROREHABIL, V13, P72, DOI 10.3109/17518420903213576
Matson JL, 2009, RES DEV DISABIL, V30, P961, DOI 10.1016/j.ridd.2009.01.009
Matson JL, 2010, RES AUTISM SPECT DIS, V4, P300, DOI 10.1016/j.rasd.2009.10.001
Matson JL, 2012, DEV NEUROREHABIL, V15, P185, DOI 10.3109/17518423.2012.672341
Matson JL, 2011, DEV NEUROREHABIL, V14, P129, DOI 10.3109/17518423.2011.557029
Matson ML, 2009, RES AUTISM SPECT DIS, V3, P868, DOI 10.1016/j.rasd.2009.02.003
Matson ML, 2011, RES DEV DISABIL, V32, P2304, DOI 10.1016/j.ridd.2011.07.036
Mattila ML, 2010, J AUTISM DEV DISORD, V40, P1080, DOI 10.1007/s10803-010-0958-2
Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P749, DOI 10.1016/j.rasd.2010.09.002
Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P1, DOI 10.1016/j.rasd.2011.08.001
Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P474, DOI 10.1016/j.rasd.2010.06.012
Newton JH, 2008, PSYCHOL SCHOOLS, V45, P523, DOI 10.1002/pits.20321
Reaven JA, 2009, FOCUS AUTISM DEV DIS, V24, P27, DOI 10.1177/1088357608327666
Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
Rieske RD, 2012, J DEV PHYS DISABIL, V24, P167, DOI 10.1007/s10882-011-9264-y
Roid G. H, 2004, ESSENTIALS STANFORD, V39
Roid G. H., 2003, STANFORD BINET INTEL
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Smith KRM, 2010, RES DEV DISABIL, V31, P743, DOI 10.1016/j.ridd.2010.01.016
Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015
Stratis EA, 2013, RES AUTISM SPECT DIS, V7, P757, DOI 10.1016/j.rasd.2013.02.017
The Psychological Corporation, 2002, WPPSI 3 TECHN INT MA
Thorson RT, 2012, RES AUTISM SPECT DIS, V6, P556, DOI 10.1016/j.rasd.2011.07.016
Turygin NC, 2013, DEV NEUROREHABIL, V16, P277, DOI 10.3109/17518423.2013.769281
VOLKMAR FR, 1991, AM J PSYCHIAT, V148, P1705
Wechsler D., 2003, WECHSLER INTELLIGENC
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
WING L, 1981, PSYCHOL MED, V11, P115
Witwer AN, 2010, J DEV PHYS DISABIL, V22, P367, DOI 10.1007/s10882-010-9194-0
NR 60
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1766
EP 1772
DI 10.1016/j.ridd.2014.02.013
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500036
PM 24656807
ER
PT J
AU Turygin, N
Matson, JL
Adams, H
AF Turygin, Nicole
Matson, Johnny L.
Adams, Hilary
TI Prevalence of co-occurring disorders in a sample of adults with mild and
moderate intellectual disabilities who reside in a residential treatment
setting
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Intellectual disability; Developmental disabilities; Dual diagnosis;
Comorbidity; Co-occurring conditions; Adults
ID PERVASIVE DEVELOPMENTAL DISORDER; ABERRANT BEHAVIOR CHECKLIST; PROFOUND
MENTAL-RETARDATION; AUTISM SPECTRUM DISORDERS; SELF-INJURIOUS-BEHAVIOR;
II DASH-II; DIAGNOSTIC-ASSESSMENT; SOCIAL-SKILLS; COMORBID
PSYCHOPATHOLOGY; PSYCHIATRIC-DISORDERS
AB The presence of an intellectual disability (ID) is associated with a myriad of co-occurring conditions, including psychiatric and genetic disorders, behavior problems, physical disabilities, and seizure disorders. Often the most severely affected individuals reside in residential treatment facilities, where they may obtain specialized treatment and management of their challenging behavior. The present study examines the prevalence of psychiatric disorders, seizures, and ID within the context of demographic categories in a sample of 101 individuals with mild to moderate ID living in a long-term residential treatment facility. Autism spectrum disorders (ASDs) were more prevalent among individuals with moderate ID, whereas personality disorders were more likely to be diagnosed in individuals with mild ID. Impulse disorders were more frequently observed in females. Further research is needed in order to determine appropriate treatment for such individuals, which should include therapies that are targeted to the specific problems of this population. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Turygin, Nicole; Matson, Johnny L.; Adams, Hilary] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Turygin, N (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM nturyg1@tigers.lsu.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
BORTHWICKDUFFY SA, 1987, AM J MENT RETARD, V92, P24
Cooper SA, 2007, SOC PSYCH PSYCH EPID, V42, P530, DOI 10.1007/s00127-007-0197-9
Cooper SA, 2007, BRIT J PSYCHIAT, V190, P27, DOI 10.1192/bjp.bp.106.022483
Dankner N., 2013, RES DEV DISABIL, V42, P57
Deb S, 2001, J INTELL DISABIL RES, V45, P495
Duncan D, 1999, RES DEV DISABIL, V20, P441, DOI 10.1016/S0891-4222(99)00024-4
Emerson E, 2001, CHALLENGING BEHAV AN
Fodstad JC, 2009, DEV NEUROREHABIL, V12, P152, DOI 10.1080/17518420902936748
Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x
Hermans H, 2013, J AFFECT DISORDERS, V144, P94, DOI 10.1016/j.jad.2012.06.011
Holwerda A, 2013, RES DEV DISABIL, V34, P1982, DOI 10.1016/j.ridd.2013.03.018
Horovitz M, 2014, RES DEV DISABIL, V35, P137, DOI 10.1016/j.ridd.2013.10.014
Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
Kim S, 2001, J INTELLECT DEV DIS, V26, P35, DOI 10.1080/13668250020032750
Lahey BB, 1999, J CHILD PSYCHOL PSYC, V40, P669, DOI 10.1017/S0021963099004047
LARSON SA, 1989, J ASSOC PERS SEVERE, V14, P324
Luckasson R., 2002, MENTAL RETARDATION D
Lunsky Y, 2003, J INTELL DISABIL RES, V47, P417, DOI 10.1046/j.1365-2788.2003.00516.x
Matson J. L., 2005, J EDUC PSYCHOL, V25, P151, DOI DOI 10.1080/0144341042000301148
Matson J. L, 2001, RES DEV DISABIL, V22, P165
Matson J. L, 1999, BEHAV MODIF, V23, P647
Matson J. L., 1997, RES DEV DISABIL, V18, P198
Matson JL, 1998, J INTELLECT DEV DIS, V23, P137, DOI 10.1080/13668259800033641
Matson JL, 1998, RES DEV DISABIL, V19, P493, DOI 10.1016/S0891-4222(98)00020-1
Matson JL, 1999, RES DEV DISABIL, V20, P305, DOI 10.1016/S0891-4222(99)00012-8
Matson JL, 2014, RES DEV DISABIL, V35, P234, DOI 10.1016/j.ridd.2013.09.043
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
Matson JL, 1997, RES DEV DISABIL, V18, P39, DOI 10.1016/S0891-4222(96)00036-4
Matson JL, 2013, RES AUTISM SPECT DIS, V7, P1318, DOI 10.1016/j.rasd.2013.07.018
Matson JL, 2008, LANCET, V371, P9, DOI 10.1016/S0140-6736(08)60046-X
Matson JL, 1997, RES DEV DISABIL, V18, P457, DOI 10.1016/S0891-4222(97)00022-X
Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
Maughan B, 2004, J CHILD PSYCHOL PSYC, V45, P609, DOI 10.1111/j.1469-7610.2004.00250.x
McDermott S, 2005, AM J MENT RETARD, V110, P48, DOI 10.1352/0895-8017(2005)110<48:POEIAW>2.0.CO;2
McGrother CW, 2006, SEIZURE-EUR J EPILEP, V15, P376, DOI 10.1016/j.seizure.2006.04.002
Mohr C, 2005, J INTELL DISABIL RES, V49, P469, DOI 10.1111/j.1365-2788.2005.00701.x
Morgan VA, 2008, BRIT J PSYCHIAT, V193, P364, DOI 10.1192/bjp.bp.107.044461
Moss S, 2001, INT REV RES MENT RET, V 24, P211, DOI 10.1016/S0074-7750(01)80010-0
Moss S, 2000, BRIT J PSYCHIAT, V177, P452, DOI 10.1192/bjp.177.5.452
Myrbakk E, 2008, RES DEV DISABIL, V29, P316, DOI 10.1016/j.ridd.2007.06.002
Paclawskyj TR, 1997, RES DEV DISABIL, V18, P289, DOI 10.1016/S0891-4222(97)00010-3
Rojahn J, 2003, RES DEV DISABIL, V24, P391, DOI 10.1016/S0891-4222(03)00055-6
Rojahn J, 2004, AM J MENT RETARD, V109, P21, DOI 10.1352/0895-8017(2004)109<21:RBPCAB>2.0.CO;2
Singh AN, 2005, RES DEV DISABIL, V26, P203, DOI 10.1016/j.ridd.2004.07.001
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Tonge BJ, 2003, INT REV RES MENT RET, V26, P61, DOI 10.1016/S0074-7750(03)01002-4
Tsakanikos E, 2011, RES AUTISM SPECT DIS, V5, P803, DOI 10.1016/j.rasd.2010.09.009
Turygin NC, 2013, J DEV PHYS DISABIL, V25, P475, DOI 10.1007/s10882-012-9321-1
Vereenooghe L, 2013, RES DEV DISABIL, V34, P4085, DOI 10.1016/j.ridd.2013.08.030
Vig S, 1999, J AUTISM DEV DISORD, V29, P235, DOI 10.1023/A:1023084106559
Wehmeyer ML, 2001, J INTELL DISABIL RES, V45, P371, DOI 10.1046/j.1365-2788.2001.00342.x
NR 53
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL
PY 2014
VL 35
IS 7
BP 1802
EP 1808
DI 10.1016/j.ridd.2014.01.027
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3GK
UT WOS:000336011500040
PM 24656808
ER
PT J
AU O'Dwyer, L
Tanner, C
van Dongen, EV
Greven, CU
Braten, J
Zwiersl, MP
Franke, B
Oosterlaan, J
Heslenfeld, D
Hoekstra, P
Hartman, CA
Rommelse, N
Buitelaar, JK
AF O'Dwyer, Laurence
Tanner, Colby
van Dongen, Eelco V.
Greven, Corina U.
Braten, Janita
Zwiersl, Marcel P.
Franke, Barbara
Oosterlaan, Jaap
Heslenfeld, Dirk
Hoekstra, Pieter
Hartman, Catharina A.
Rommelse, Nanda
Buitelaar, Jan K.
TI Brain Volumetric Correlates of Autism Spectrum Disorder Symptoms in
Attention Deficit/Hyperactivity Disorder
SO PLOS ONE
LA English
DT Article
ID DEFICIT HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
BEHAVIOR QUESTIONNAIRE CSBQ; LARGE MULTICENTER ADHD; REPETITIVE
BEHAVIORS; DIAGNOSTIC-APPROACH; LANGUAGE DISORDER; CORPUS-CALLOSUM;
CAUDATE-NUCLEUS; FAMILIAL TRAIT
AB Autism spectrum disorder (ASD) symptoms frequently occur in subjects with attention deficit/hyperactivity disord (ADHD). While there is evidence that both ADHD and ASD have differential structural correlates, no study to date has nvestigated these structural correlates within a framework that robustly accounts for the phenotypic overlap between the two disorders. The presence of ASD symptoms was measured by the parent-reported Children's Social and Behavioural Questionnaire (CSBQ) in ADHD subject n = 180) their unaffected siblings (n = 118) and healthy controls (n = 146). ADHD symptoms were assessed by a structured interview K-SADS-PL) and the Conners' ADHD questionnaires. Whole brain T1 Weighted MPRAGE images were acquired and the structural MRI correlates of ASD symptom scores were analysed by modelling ASD symptom scores against white matter (WM) and grey matter (GM) volumes using mixed effects models which controlled for ADHD symptom levels. ASD symptoms were significantly elevated in ADHD subjects relative to bot h controls and unaffected siblings. ASD scores were predicted by the interaction between WM and GM volumes. Increasing ASD score was associated with greater GM volume. Equivocal results from previous structural studies in ADHD and ASD may be due to the fact that comorbidity has not been taken into account in studies to date. The current findings stress he need. to account for issues of ASD comorbidity ADHD.
C1 [O'Dwyer, Laurence; van Dongen, Eelco V.; Greven, Corina U.; Braten, Janita; Zwiersl, Marcel P.; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
[Tanner, Colby] Univ Lausanne, Dept Ecol & Evolut, Lausanne, Switzerland.
[Greven, Corina U.] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, London WC2R 2LS, England.
[Braten, Janita; Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
[Franke, Barbara; Rommelse, Nanda] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands.
[Oosterlaan, Jaap; Heslenfeld, Dirk] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands.
[Heslenfeld, Dirk] Vrije Univ Amsterdam, Dept Cognit Psychol, Amsterdam, Netherlands.
[Hoekstra, Pieter; Hartman, Catharina A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
[Rommelse, Nanda; Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Ctr Nij, Nijmegen, Netherlands.
RP O'Dwyer, L (reprint author), Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
EM larodwyer@gmail.com
RI Zwiers, Marcel/D-2968-2009; Franke, Barbara/D-4836-2009
OI Zwiers, Marcel/0000-0001-5483-2935; Franke, Barbara/0000-0003-4375-6572
FU National Institutes of Health [RO1MH62873]; NWO Large Investment Grant
[1750102007010]; Radboud University Nijmegen Medical Center; University
Medical Center Groningen and Accare; Vrije Universiteit Amsterdam;
European Community's Seventh Framework Programme [278948]; Innovative
Medicines Initiative Joint Undertaking (IMI) under (EU-AIMS)
[115300-01]; Irish Research Council for Science, Engineering and
Technology (IRCSET)
FX The NeuroIMAGE study was supported by National Institutes of Health
grant RO1MH62873 (to Stephen V. Faraone), NWO Large Investment Grant
1750102007010 (to Jan Buitelaar) and matching grants from Radboud
University Nijmegen Medical Center, University Medical Center Groningen
and Accare, and Vrije Universiteit Amsterdam. The research leading to
these results also received support from the European Community's
Seventh Framework Programme (FP7/2007-2013) under grant agreement number
278948 (TACTICS), and from the Innovative Medicines Initiative Joint
Undertaking (IMI) under grant agreement number 115300-01 (EU-AIMS). CT
was supported by a fellowship from the Irish Research Council for
Science, Engineering and Technology (IRCSET). The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR AKAIKE H, 1979, BIOMETRIKA, V66, P237
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
Ames CS, 2011, J AUTISM DEV DISORD, V41, P357, DOI 10.1007/s10803-010-1049-0
Anderson D.R, 2002, MODEL SELECTION MULT
Asato MR, 2010, CEREB CORTEX, V20, P2122, DOI 10.1093/cercor/bhp282
Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
Association AP, 2000, DIAGNOTIC STAT MANUA
Bates D, IME4 LINEAR MIXED EF
Booth R, 2010, J EXP CHILD PSYCHOL, V107, P377, DOI 10.1016/j.jecp.2010.06.003
Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x
Bussing Regina, 2002, World J Biol Psychiatry, V3, P216, DOI 10.3109/15622970209150624
Carmona S, 2005, NEUROSCI LETT, V389, P88, DOI 10.1016/j.neulet.2005.07.020
Castellanos FX, 2002, NAT REV NEUROSCI, V3, P617, DOI 10.1038/nrn896
Chabernaud C, 2012, BIOL PSYCHIAT, V71, P434, DOI 10.1016/j.biopsych.2011.08.013
Chung MK, 2004, NEUROIMAGE, V23, P242, DOI 10.1016/j.neuroimage.2004.04.037
Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
Crawley M.J., 2007, R BOOK
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
de Bildt A, 2009, J AUTISM DEV DISORD, V39, P1464, DOI 10.1007/s10803-009-0764-x
DIVAC I, 1967, J COMP PHYSIOL PSYCH, V63, P184, DOI 10.1037/h0024348
Dosenbach NUF, 2010, SCIENCE, V329, P1358, DOI 10.1126/science.1194144
Durston S, 2004, J AM ACAD CHILD PSY, V43, P332, DOI 10.1097/01.chi.0000107729.75340.f3
Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P57, DOI 10.1007/s10803-008-0599-x
Fine JG, 2008, J AUTISM DEV DISORD, V38, P1797, DOI 10.1007/s10803-008-0570-x
Freitag CM, 2009, BIOL PSYCHIAT, V66, P316, DOI 10.1016/j.biopsych.2009.03.011
Frodl T, 2012, ACTA PSYCHIAT SCAND, V125, P114, DOI 10.1111/j.1600-0447.2011.01786.x
Geluk CAML, 2012, J CHILD PSYCHOL PSYC, V53, P160, DOI 10.1111/j.1469-7610.2011.02456.x
Geurts HM, 2008, J CHILD PSYCHOL PSYC, V49, P848, DOI 10.1111/j.1469-7610.2008.01916.x
Geurts HM, 2013, J AUTISM DEV DISORD, V43, P1630, DOI 10.1007/s10803-012-1708-4
Grahn JA, 2009, BEHAV BRAIN RES, V199, P53, DOI 10.1016/j.bbr.2008.11.020
Greaves-Lord K, 2013, J AUTISM DEV DISORD, V43, P1784, DOI 10.1007/s10803-012-1724-4
Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
't Hart-Kerkhoffs LA, 2009, J CLIN PSYCHIAT, V70, P266
Hartman CA, 2006, J AUTISM DEV DISORD, V36, P325, DOI 10.1007/s10803-005-0072-z
Heimer L, 2003, AM J PSYCHIAT, V160, P1726, DOI 10.1176/appi.ajp.160.10.1726
Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
Herbert MR, 2005, NEUROSCIENTIST, V11, P417, DOI 10.1177/0091270005278866
Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
Hesslinger B, 2002, NEUROSCI LETT, V328, P319, DOI 10.1016/S0304-3940(02)00554-2
Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
HYND GW, 1990, ARCH NEUROL-CHICAGO, V47, P919
Jaspers M, 2013, J ABNORM CHILD PSYCH, V41, P71, DOI 10.1007/s10802-012-9653-4
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
KIRKBY RJ, 1969, PHYSIOL BEHAV, V4, P451, DOI 10.1016/0031-9384(69)90135-8
Kleinhans NM, 2012, BRAIN RES, V1479, P1, DOI 10.1016/j.brainres.2012.07.056
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Luteijn EF, 2000, EUR CHILD ADOLES PSY, V9, P168
Lyoo IK, 1996, BIOL PSYCHIAT, V40, P1060
Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
Mostofsky SH, 2002, BIOL PSYCHIAT, V52, P785, DOI 10.1016/S0006-3223(02)01412-9
Muller UC, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-55
Muller UC, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-54
Mulligan A, 2009, J AUTISM DEV DISORD, V39, P197, DOI 10.1007/s10803-008-0621-3
Nakao T, 2011, AM J PSYCHIAT, V168, P1154, DOI 10.1176/appi.ajp.2011.11020281
Nickl-Jockschat T, 2012, HUM BRAIN MAPP, V33, P1470, DOI 10.1002/hbm.21299
Nijmeijer JS, 2014, J AUTISM DEV DISORD, V44, P1671, DOI 10.1007/s10803-014-2039-4
Nijmeijer JS, 2009, J ABNORM CHILD PSYCH, V37, P443, DOI 10.1007/s10802-008-9282-0
O'Dwyer L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048895
PFEFFERBAUM A, 1994, ARCH NEUROL-CHICAGO, V51, P874
Piven J, 1996, J AM ACAD CHILD PSY, V35, P530, DOI 10.1097/00004583-199604000-00020
R Development Core Team, 2010, R LANG ENV STAT COMP
Radua J, 2011, PSYCHOL MED, V41, P1539, DOI 10.1017/S0033291710002187
Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Scarpa A, 2011, BEHAV COGN PSYCHOTH, V39, P495, DOI 10.1017/S1352465811000063
Schultz W, 2000, CEREB CORTEX, V10, P272, DOI 10.1093/cercor/10.3.272
Seidman LJ, 2011, BIOL PSYCHIAT, V69, P857, DOI 10.1016/j.biopsych.2010.09.053
Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
Shaw P, 2010, HUM BRAIN MAPP, V31, P917, DOI 10.1002/hbm.21028
Shaw P, 2011, AM J PSYCHIAT, V168, P143, DOI 10.1176/appi.ajp.2010.10030385
Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
STETTNER LJ, 1967, SCIENCE, V155, P1689, DOI 10.1126/science.155.3770.1689
Sze KM, 2008, BEHAV COGNITIVE PSYC, V36
Taylor JL, 2010, J AUTISM DEV DISORD, V40, P1431, DOI 10.1007/s10803-010-1005-z
THOMPSON RL, 1959, J COMP PHYSIOL PSYCH, V52, P650, DOI 10.1037/h0038893
Vaccarino FM, 2009, J AUTISM DEV DISORD, V39, P511, DOI 10.1007/s10803-008-0653-8
Valera EM, 2007, BIOL PSYCHIAT, V61, P1361, DOI 10.1016/j.biopsych.2006.06.011
van der Meer JMJ, 2012, J AM ACAD CHILD PSY, V51, P1160, DOI 10.1016/j.jaac.2012.08.024
van Steijn DJ, 2012, J CHILD PSYCHOL PSYC, V53, P954, DOI 10.1111/j.1469-7610.2012.02556.x
Via E, 2011, ARCH GEN PSYCHIAT, V68, P409, DOI 10.1001/archgenpsychiatry.2011.27
Waiter GD, 2005, NEUROIMAGE, V24, P455, DOI 10.1016/j.neuroimage.2004.08.049
NR 91
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 30
PY 2014
VL 9
IS 6
AR e101130
DI 10.1371/journal.pone.0101130
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK5ZO
UT WOS:000338506400083
PM 24979066
ER
PT J
AU Kuypers, KPC
de la Torre, R
Farre, M
Yubero-Lahoz, S
Dziobek, I
Van den Bos, W
Ramaekers, JG
AF Kuypers, Kim P. C.
de la Torre, Rafael
Farre, Magi
Yubero-Lahoz, Samanta
Dziobek, Isabel
Van den Bos, Wouter
Ramaekers, Johannes G.
TI No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is
Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; SOCIAL-BEHAVIOR;
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; INTRANASAL OXYTOCIN; PROSOCIAL
FEELINGS; HEALTHY-VOLUNTEERS; VERBAL MEMORY; BETA-BLOCKER; ECSTASY;
HUMANS
AB The present study aimed at investigating the effect of MDMA on measures of empathy and social interaction, and the roles of oxytocin and the 5-HT1A receptor in these effects. The design was placebo-controlled within-subject with 4 treatment conditions: MDMA (75 mg), with or without pindolol (20 mg), oxytocin nasal spray (40 IU+16 IU) or placebo. Participants were 20 healthy poly-drug MDMA users, aged between 18-26 years. Cognitive and emotional empathy were assessed by means of the Reading the Mind in the Eyes Test and the Multifaceted Empathy Test. Social interaction, defined as trust and reciprocity, was assessed by means of a Trust Game and a Social Ball Tossing Game. Results showed that MDMA selectively affected emotional empathy and left cognitive empathy, trust and reciprocity unaffected. When combined with pindolol, these effects remained unchanged. Oxytocin did not affect measures of empathy and social interaction. Changes in emotional empathy were not related to oxytocin plasma levels. It was concluded that MDMA (75 mg) selectively enhances emotional empathy in humans. While the underlying neurobiological mechanism is still unknown, it is suggested that peripheral oxytocin does not seem to be the main actor in this; potential candidates are the serotonin 2A and the vasopressin 1A receptors.
C1 [Kuypers, Kim P. C.; Ramaekers, Johannes G.] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands.
[de la Torre, Rafael; Farre, Magi; Yubero-Lahoz, Samanta] Hosp Mar, IMIM, Res Inst, Human Pharmacol & Clin Neurosci Res Grp, Barcelona, Spain.
[Dziobek, Isabel] Free Univ Berlin, Berlin, Germany.
[Van den Bos, Wouter] Max Planck Inst Human Dev, Ctr Adapt Rational ARC, Berlin, Germany.
RP Kuypers, KPC (reprint author), Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands.
EM k.kuypers@maastrichtuniversity.nl
FU Netherlands Organization for Scientific Research (NWO) [400-07-2013]
FX This work was supported by the Netherlands Organization for Scientific
Research (NWO), Grant number: 400-07-2013, awarded to JR and KK. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Bankson MG, 2001, J PHARMACOL EXP THER, V297, P846
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Bartels A, 2012, NEUROPSYCHOPHARMACOL, V37, P1795, DOI 10.1038/npp.2012.71
Bedi G, 2009, PSYCHOPHARMACOLOGY, V207, P73, DOI 10.1007/s00213-009-1635-z
Bedi G, 2010, BIOL PSYCHIAT, V68, P1134, DOI 10.1016/j.biopsych.2010.08.003
Born J, 2002, NAT NEUROSCI, V5, P514, DOI 10.1038/nn849
Bright P, 2002, J INT NEUROPSYCH SOC, V8, P847, DOI 10.1017/S1355617702860131
Bull EJ, 2004, NEUROPHARMACOLOGY, V46, P202, DOI 10.1016/j.neuropharm.2003.08.004
Campbell A, 2010, PERS SOC PSYCHOL REV, V14, P281, DOI 10.1177/1088868310363594
Crawford JR, 2001, PSYCHOL MED, V31, P451
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Declerck CH, 2010, HORM BEHAV, V57, P368, DOI 10.1016/j.yhbeh.2010.01.006
de Wit H, 2002, NEUROPSYCHOPHARMACOL, V27, P813, DOI 10.1016/S0893-133X(02)00343-3
Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015
Dumont GJH, 2006, J PSYCHOPHARMACOL, V20, P176, DOI 10.1177/0269881106063271
Dumont GJH, 2009, SOC NEUROSCI-UK, V4, P359, DOI 10.1080/17470910802649470
Emanuele E, 2006, MED HYPOTHESES, V67, P1250, DOI 10.1016/j.mehy.2006.05.021
Fertuck EA, 2009, PSYCHOL MED, V39, P1979, DOI 10.1017/S003329170900600X
Frye CG, 2014, PHARMACOL BIOCHEM BE, V117, P1, DOI 10.1016/j.pbb.2013.11.030
Gossen A, 2012, NEUROPEPTIDES, V46, P211, DOI 10.1016/j.npep.2012.07.001
Guroglu B, 2010, SOC COGN AFFECT NEUR, V5, P414, DOI 10.1093/scan/nsq013
Harkness KL, 2005, COGNITION EMOTION, V19, P999, DOI 10.1080/02699930541000110
Hasler F, 2009, J PSYCHOPHARMACOL, V23, P923, DOI 10.1177/0269881108094650
HOLM S, 1979, SCAND J STAT, V6, P65
Hurlemann R, 2010, J NEUROSCI, V30, P4999, DOI 10.1523/JNEUROSCI.5538-09.2010
Hysek CM, 2014, SOC COGN AFFECT NEUR, V9, P1645, DOI 10.1093/scan/nst161
Hysek CM, 2012, PSYCHOPHARMACOLOGY, V222, P293, DOI 10.1007/s00213-012-2645-9
Hysek CM, 2010, EMERG MED J, V27, P586, DOI 10.1136/emj.2009.079905
Jorgensen H, 2003, J NEUROENDOCRINOL, V15, P242, DOI 10.1046/j.1365-2826.2003.00978.x
Kirkpatrick MG, 2014, NEUROPSYCHOPHARMACOL, V39, P1654, DOI 10.1038/npp.2014.12
Kosfeld M, 2005, NATURE, V435, P673, DOI 10.1038/nature03701
Kuypers KPC, 2013, BRIT J PHARMACOL, V168, P607, DOI 10.1111/j.1476-5381.2012.02196.x
McElrath K, 2002, J PSYCHOACTIVE DRUGS, V34, P199
Mithoefer MC, 2013, J PSYCHOPHARMACOL, V27, P28, DOI 10.1177/0269881112456611
Mulder-Hajonides van der Meulen W.R.E.H., 1980, 5 EUR C SLEEP RES AM
Nejtek VA, 2002, PSYCHONEUROENDOCRINO, V27, P337, DOI 10.1016/S0306-4530(01)00055-5
Peroutka SJ, 1988, NEUROPSYCHOPHARMACOL, V1, P1
Pizarro N, 2002, J ANAL TOXICOL, V26, P157
Rabiner EA, 2000, NEUROPSYCHOPHARMACOL, V23, P285, DOI 10.1016/S0893-133X(00)00109-3
Ramos L, 2013, NEUROPSYCHOPHARMACOL, V38, P2249, DOI 10.1038/npp.2013.125
Rey A., 1958, CLIN EXAMINATION PSY
Scahill L, 2010, BIOL PSYCHIAT, V68, P1082, DOI 10.1016/j.biopsych.2010.10.020
Schmand B, 1991, Tijdschr Gerontol Geriatr, V22, P15
Shamay-Tsoory SG, 2009, BIOL PSYCHIAT, V66, P864, DOI 10.1016/j.biopsych.2009.06.009
Singer T, 2008, EMOTION, V8, P781, DOI 10.1037/a0014195
Striepens N, 2013, SCI REP-UK, V3, DOI 10.1038/srep03440
Sumnall HR, 2006, J PSYCHOPHARMACOL, V20, P670, DOI 10.1177/0269881106060764
Thompson MR, 2007, NEUROSCIENCE, V146, P509, DOI 10.1016/j.neuroscience.2007.02.032
van den Bos W, 2014, SOC COGN AFFECT NEUR, V9, P2059, DOI 10.1093/scan/nsu003
van Wel JHP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040187
van den Bos W, 2011, PSYCHOL SCI, V22, P60, DOI 10.1177/0956797610391102
van den Bos W, 2009, SOC COGN AFFECT NEUR, V4, P294, DOI 10.1093/scan/nsp009
van Wel JHP, 2011, NEUROPSYCHOPHARMACOL, V36, P1932, DOI 10.1038/npp.2011.80
NR 54
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 27
PY 2014
VL 9
IS 6
AR e100719
DI 10.1371/journal.pone.0100719
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK6BK
UT WOS:000338512200053
PM 24972084
ER
PT J
AU Caruana, N
Brock, J
AF Caruana, Nathan
Brock, Jon
TI No association between autistic traits and contextual influences on
eye-movements during reading
SO PEERJ
LA English
DT Article
DE Autism; Autistic traits; Eye-movements; Reading; Sentence context;
Reading comprehension; Semantic processing; Central coherence
ID LEXICAL AMBIGUITY RESOLUTION; SPECTRUM QUOTIENT AQ; CENTRAL COHERENCE;
VISUAL-SEARCH; FIXATION TIMES; PERCEPTION; CHILDREN; MIND;
COMPREHENDERS; INDIVIDUALS
AB Individuals with autism spectrum disorders are claimed to show a local cognitive bias, termed "weak central coherence", which manifests in a reduced influence of contextual information on linguistic processing. Here, we investigated whether this bias might also be demonstrated by individuals who exhibit sub-clinical levels of autistic traits, as has been found for other aspects of autistic cognition. The eye-movements of 71 university students were monitored as they completed a reading comprehension task. Consistent with previous studies, participants made shorter fixations on words that were highly predicted on the basis of preceding sentence context. However, contrary to the weak central coherence account, this effect was not reduced amongst individuals with high levels of autistic traits, as measured by the Autism Spectrum Quotient (AQ). Further exploratory analyses revealed that participants with high AQ scores fixated longer on words that resolved the meaning of an earlier homograph. However, this was only the case for sentences where the two potential meanings of the homograph result in different pronunciations. The results provide tentative evidence for differences in reading style that are associated with autistic traits, but fail to support the notion of weak central coherence extending into the non-autistic population.
C1 [Caruana, Nathan; Brock, Jon] Macquarie Univ, Dept Cognit Sci, Sydney, NSW 2109, Australia.
[Brock, Jon] Macquarie Univ, Dept Psychol, Sydney, NSW 2109, Australia.
EM jon.brock@mq.edu.au
FU Australian Research Council Australian Research Fellowship [DP098466];
Australian Research Council Centre of Excellence in Cognition and its
Disorders [CE110001021]
FX Jon Brock was supported by an Australian Research Council Australian
Research Fellowship (Grant DP098466). He is a Chief Investigator at the
Australian Research Council Centre of Excellence in Cognition and its
Disorders (Grant CE110001021). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
CR Almeida RA, 2010, NEUROPSYCHOLOGIA, V48, P374, DOI 10.1016/j.neuropsychologia.2009.09.024
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baayen R. H., 2010, INT J PSYCHOL RES, V3, P12
Baayen RH, 2008, J MEM LANG, V59, P390, DOI 10.1016/j.jml.2007.12.005
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Barr DJ, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00328
Barr DJ, 2013, J MEM LANG, V68, P255, DOI 10.1016/j.jml.2012.11.001
Bates D., 2005, R NEWS, V5, P27, DOI DOI 10.1111/J.1523-1739.2005.00280.X
Brock J, 2014, COMMUNICATION AUTISM, P121
Brock J, 2013, Q J EXP PSYCHOL, V66, P1764, DOI 10.1080/17470218.2013.766221
Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007
Brock J, 2011, PERCEPTION, V40, P739, DOI 10.1068/p6953
Burnette CP, 2005, J AUTISM DEV DISORD, V35, P63, DOI 10.1007/s10803-004-1035-5
DUFFY SA, 1988, J MEM LANG, V27, P429, DOI 10.1016/0749-596X(88)90066-6
Ehrlich MF, 1996, READING COMPREHENSION DIFFICULTIES, P221
Ehrlich MF, 1999, READ WRIT, V11, P29, DOI 10.1023/A:1007996502372
EHRLICH SF, 1981, J VERB LEARN VERB BE, V20, P641, DOI 10.1016/S0022-5371(81)90220-6
Frith U., 1983, BRIT J DEV PSYCHOL, V1, P329, DOI 10.1111/j.2044-835X.1983.tb00906.x
Frith U., 1989, AUTISM EXPLAINING EN
Gregory BL, 2013, J AUTISM DEV DISORD, DOI [10.1007/s10803-013-1951-3, DOI 10.1007/S10803-013-1951-3]
Happe FGE, 1997, BRIT J DEV PSYCHOL, V15, P1
Henderson LM, 2011, J CHILD PSYCHOL PSYC, V52, P964, DOI 10.1111/j.1469-7610.2011.02393.x
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Hohenstein S, 2010, J EXP PSYCHOL LEARN, V36, P1150, DOI 10.1037/a0020233
Jolliffe T, 1999, COGNITION, V71, P149, DOI 10.1016/S0010-0277(99)00022-0
KALIKOW DN, 1977, J ACOUST SOC AM, V61, P1337, DOI 10.1121/1.381436
Kliegl R, 2006, J EXP PSYCHOL GEN, V135, P12, DOI 10.1037/0096-3445.135.1.12
Lopez B, 2003, J CHILD PSYCHOL PSYC, V44, P285, DOI 10.1111/1469-7610.00121
Milne E, 2013, NEUROPSYCHOLOGIA, V51, P1109, DOI 10.1016/j.neuropsychologia.2013.03.002
Norbury CF, 2005, J EXP CHILD PSYCHOL, V90, P142, DOI 10.1016/j.jecp.2004.11.003
Oakhill J., 1991, CHILDRENS PROBLEMS T
R Development Core Team, 2012, R LANG ENV STAT COMP
Rayner K, 1996, PSYCHON B REV, V3, P504, DOI 10.3758/BF03214555
RAYNER K, 1986, MEM COGNITION, V14, P191, DOI 10.3758/BF03197692
Rayner K, 2009, Q J EXP PSYCHOL, V62, P1457, DOI 10.1080/17470210902816461
Shipley W. C., 2009, SHIPLEY 2 MANUAL
SNOWLING M, 1986, J EXP CHILD PSYCHOL, V42, P392, DOI 10.1016/0022-0965(86)90033-0
SR Research, 2004, EXP BUILD VERS 1 10
Stewart ME, 2008, COGNITION, V109, P157, DOI 10.1016/j.cognition.2008.07.010
van der Schoot M, 2009, J EDUC PSYCHOL, V101, P21, DOI 10.1037/a0013382
Voracek M, 2006, HUM REPROD, V21, P1329, DOI 10.1093/humrep/dei464
Zubrucky K, 1989, READING RES Q, V24, P336, DOI [10.2307/747773, DOI 10.2307/747773]
NR 42
TC 0
Z9 0
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD JUN 26
PY 2014
VL 2
AR e466
DI 10.7717/peerj.466
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AY5KP
UT WOS:000347611300010
PM 25024927
ER
PT J
AU Wu, XY
Bai, YR
Tan, T
Li, HJ
Xia, ST
Chang, XX
Zhou, ZK
Zhou, WH
Li, TY
Wang, YT
Dong, ZF
AF Wu, Xiaoyan
Bai, Yanrui
Tan, Tao
Li, Hongjie
Xia, Shuting
Chang, Xinxia
Zhou, Zikai
Zhou, Weihui
Li, Tingyu
Wang, Yu Tian
Dong, Zhifang
TI Lithium ameliorates autistic-like behaviors induced by neonatal
isolation in rats
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE neonatal isolation; autism spectrum disorder; social deficit;
neurogenesis; spontaneous inhibitory postsynaptic current
ID GLYCOGEN-SYNTHASE KINASE-3; MATERNAL SEPARATION; SPECTRUM DISORDERS;
FEMALE RATS; MOUSE MODELS; HIPPOCAMPAL NEUROGENESIS;
PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; NEUROPEPTIDE-Y; DENTATE GYRUS
AB Neonatal isolation is a widely accepted model to study the long-term behavioral changes produced by the early life events. However, it remains unknown whether neonatal isolation can induce autistic-like behaviors, and if so, whether pharmacological treatment can overcome it. Here, we reported that newborn rats subjected to individual isolations from their mother and nest for 1 h per day from postnatal days 1-9 displayed apparent autistic-like symptoms including social deficits, excessive repetitive self-grooming behavior, and increased anxiety- and depressive-like behaviors tested in young adult (postnatal days 42-56) compared to normal reared controls. Furthermore, these behavioral changes were accompanied by impaired adult hippocampal neurogenesis and reduced the ratio of excitatory/inhibitory synaptic transmissions, as reflected by an increase in spontaneous inhibitory postsynaptic current (sIPSC) and normal spontaneous excitatory postsynaptic current (sEPSC) in the hippocampal CA1 pyramidal neuron. More importantly, chronic administration of lithium, a clinically used mood stabilizer, completely overcame neonatal isolation-induced autistic-like behaviors, and restored adult hippocampal neurogenesis as well as the balance between excitatory and inhibitory activities to physiological levels. These findings indicate that neonatal isolation may produce autistic-like behaviors, and lithium may be a potential therapeutic agent against autism spectrum disorders (ASD) during development.
C1 [Wu, Xiaoyan; Bai, Yanrui; Tan, Tao; Li, Hongjie; Zhou, Weihui; Li, Tingyu; Wang, Yu Tian; Dong, Zhifang] Chongqing Med Univ, Minist Educ, Key Lab Child Dev & Disorders, Childrens Hosp, Chongqing 400014, Peoples R China.
[Wu, Xiaoyan; Bai, Yanrui; Tan, Tao; Li, Hongjie; Zhou, Weihui; Li, Tingyu; Dong, Zhifang] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R China.
[Xia, Shuting; Chang, Xinxia; Zhou, Zikai] Southeast Univ, Inst Life Sci, Minist Educ, Key Lab Dev Genes & Human Dis, Nanjing, Jiangsu, Peoples R China.
[Wang, Yu Tian] Univ British Columbia, Brain Res Ctr, Vancouver, BC V5Z 1M9, Canada.
RP Dong, ZF (reprint author), Chongqing Med Univ, Minist Educ, Key Lab Child Dev & Disorders, Childrens Hosp, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China.
EM zfdong@cqmu.edu.cn
FU Ministry of Science and Technology of China [2012CB517903,
2014CB548100]; National Natural Science Foundation of China [81271221,
31040085, 31200805, 81070269, 81161120498]; Chongqing International
Science and technology Cooperation Foundation [cstc201110003]
FX We thank Dr. Loren W. Oschipok for his excellent editorial assistance.
This work was supported by 973 Program of the Ministry of Science and
Technology of China (2012CB517903 to Zhifang Dong and Weihui Zhou,
2014CB548100 to Zhifang Dong), the National Natural Science Foundation
of China (81271221 and 31040085 to Zhifang Dong, 31200805 to Zikai Zhou,
81070269 to Weihui Zhou and 81161120498 to Tingyu Li), and the Chongqing
International Science and technology Cooperation Foundation
(cstc201110003 to Zhifang Dong). Yu Tian Wang is the holder of the
HSFBC/Y chair in stroke research.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, P66
Arndt TL, 2005, INT J DEV NEUROSCI, V23, P189, DOI 10.1016/j.ijdevneu.2004.11.001
BAILEY A, 1995, PSYCHOL MED, V25, P63
Beaulieu JM, 2004, P NATL ACAD SCI USA, V101, P5099, DOI 10.1073/pnas.0307921101
Bianchi P, 2010, BRAIN PATHOL, V20, P106, DOI 10.1111/j.1750-3639.2008.00246.x
Bishop SL, 2011, AUTISM RES, V4, P317, DOI 10.1002/aur.216
Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
Brown JP, 2003, J COMP NEUROL, V467, P1, DOI 10.1002/cne.10874
Chen G, 2000, J NEUROCHEM, V75, P1729, DOI 10.1046/j.1471-4159.2000.0751729.x
Christensen J, 2013, JAMA-J AM MED ASSOC, V309, P1696, DOI 10.1001/jama.2013.2270
CHRISTIANSON AL, 1994, DEV MED CHILD NEUROL, V36, P361
Contestabile A, 2013, J CLIN INVEST, V123, P348, DOI 10.1172/JCI64650
De Ferrari GV, 2003, MOL PSYCHIATR, V8, P195, DOI 10.1038/sj.mp.4001208
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006
Francis DD, 2002, J NEUROSCI, V22, P7840
Guo WX, 2011, NAT MED, V17, P559, DOI 10.1038/nm.2336
Haider S, 2006, AMINO ACIDS, V31, P421, DOI 10.1007/s00726-005-0310-x
Hansel DE, 2001, NATURE, V410, P940, DOI 10.1038/35073601
Husum H, 2002, NEUROPSYCHOPHARMACOL, V27, P756, DOI 10.1016/S0893-133X(02)00363-9
Jope RS, 1999, MOL PSYCHIATR, V4, P117, DOI 10.1038/sj.mp.4000494
Jope RS, 2003, TRENDS PHARMACOL SCI, V24, P441, DOI 10.1016/S0165-6147(03)00206-2
Kehoe P, 1996, BEHAV NEUROSCI, V110, P1435, DOI 10.1037/0735-7044.110.6.1435
KEHOE P, 1995, EXP NEUROL, V136, P89, DOI 10.1006/exnr.1995.1086
Kikusui T, 2009, PSYCHONEUROENDOCRINO, V34, P762, DOI 10.1016/j.psyneuen.2008.12.009
Kosten TA, 2007, NEUROBIOL LEARN MEM, V88, P167, DOI 10.1016/j.nlm.2007.03.011
Kosten TA, 2006, NEUROPSYCHOPHARMACOL, V31, P70, DOI 10.1038/sj.npp.1300779
KUHN CM, 1990, DEV PSYCHOBIOL, V23, P395, DOI 10.1002/dev.420230503
Lewis CS, 2013, ALLEGORY OF LOVE: A STUDY IN MEDIEVAL TRADITION, P55
Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Li HF, 2011, J CEREBR BLOOD F MET, V31, P2106, DOI 10.1038/jcbfm.2011.75
Makena N, 2012, METAB BRAIN DIS, V27, P377, DOI 10.1007/s11011-012-9298-6
Manji HK, 2000, BIOL PSYCHIAT, V48, P740, DOI 10.1016/S0006-3223(00)00979-3
Marco EM, 2013, NEUROPHARMACOLOGY, V68, P223, DOI 10.1016/j.neuropharm.2012.08.014
Mazefsky CA, 2010, AUTISM RES, V3, P120, DOI 10.1002/aur.133
Monroy E, 2010, J CHEM NEUROANAT, V40, P93, DOI 10.1016/j.jchemneu.2010.05.005
Mulvihill B., 2009, MMWR SURVEILL SUMM, V58, P1
Nonaka S, 1998, NEUROREPORT, V9, P2081, DOI 10.1097/00001756-199806220-00031
O'Brien WT, 2004, J NEUROSCI, V24, P6791, DOI 10.1523/JNEUROSCI.4753-03.2004
Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025
Perveen T, 2013, PHARMACOL REP, V65, P336
Pizzarelli R, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00085
Plotsky PM, 2005, NEUROPSYCHOPHARMACOL, V30, P2192, DOI 10.1038/sj.npp.1300769
Porter RJ, 2003, PSYCHOL MED, V33, P41, DOI 10.1017/S0033291702006906
Qing H, 2008, J EXP MED, V205, P2781, DOI 10.1084/jem.20081588
Racekova E, 2009, CELL MOL NEUROBIOL, V29, P811, DOI 10.1007/s10571-009-9362-x
Ren M, 2003, P NATL ACAD SCI USA, V100, P6210, DOI 10.1073/pnas.0937423100
Rhees RW, 2001, BEHAV BRAIN RES, V123, P1, DOI 10.1016/S0166-4328(00)00381-8
Rizzi S, 2007, HIPPOCAMPUS, V17, P78, DOI 10.1002/hipo.20247
Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
Ryves WJ, 2001, BIOCHEM BIOPH RES CO, V280, P720, DOI 10.1006/bbrc.2000.4169
Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
Senatorov VV, 2004, MOL PSYCHIATR, V9, P371, DOI 10.1038/sj.mp.4001463
Shin WJ, 2012, CHILD NERV SYST, V28, P191, DOI 10.1007/s00381-011-1627-2
Silva R, 2008, NEUROSCIENCE, V152, P656, DOI 10.1016/j.neuroscience.2007.12.026
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Son H, 2003, J NEUROCHEM, V85, P872, DOI 10.1046/j.1471-4159.2003.01725.x
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
Takatsuru Y, 2009, BRAIN RES, V1294, P45, DOI 10.1016/j.brainres.2009.07.092
Tsuda MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033028
Weaver SA, 2007, J PAIN, V8, P962, DOI 10.1016/j.jpain.2007.07.001
Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
Zhang F, 2003, J BIOL CHEM, V278, P33067, DOI 10.1074/jbc.M212635200
NR 68
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD JUN 26
PY 2014
VL 8
AR 234
DI 10.3389/fnbeh.2014.00234
PG 12
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AK1SC
UT WOS:000338195200001
PM 25018711
ER
PT J
AU Chen, CH
Huang, CC
Cheng, MC
Chiu, YN
Tsai, WC
Wu, YY
Liu, SK
Gau, SSF
AF Chen, Chia-Hsiang
Huang, Chia-Chun
Cheng, Min-Chih
Chiu, Yen-Nan
Tsai, Wen-Che
Wu, Yu-Yu
Liu, Shih-Kai
Gau, Susan Shur-Fen
TI Genetic analysis of GABRB3 as a candidate gene of autism spectrum
disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorders; GABRB3; Rare variants; Genetics; Case-control
association
ID RECEPTOR SUBUNIT GENES; AMINOBUTYRIC-ACID RECEPTOR; INTERNATIONAL
NEUROPSYCHIATRIC INTERVIEW; PERVASIVE DEVELOPMENTAL DISORDERS; CHILDHOOD
ABSENCE EPILEPSY; MESSENGER-RNA LEVELS; GABA(A) RECEPTOR;
LINKAGE-DISEQUILIBRIUM; CHROMOSOME 15Q11-Q13; PSYCHOMETRIC PROPERTIES
AB Background: GABRB3 is a position candidate gene at chromosome 15q12 that has been implicated in the neurobiology of autism spectrum disorders (ASD). The aim of this study was to examine the genetic association of GABRB3 with ASD.
Methods: The sample consisted of 356 patients with clinical diagnosis of ASD according to the DSM-IV diagnostic criteria and confirmed by the Autism Diagnostic Interview-Revised and 386 unrelated controls. We searched for mutations at all the exonic regions and 1.6 Kb of the 5' region of GABRB3 in the genomic DNA of all the participants using the Sanger sequencing. We implemented a case-control association analysis of variants detected in this sample, and conducted a reporter gene assay to assess the functional impact of variants at the 5' regulatory region.
Results: We detected six known common SNPs; however, they were not associated with ASD. Besides, a total of 22 rare variants (12 at 5' regulatory, 4 at intronic, and 6 at exonic regions) were detected in 18 patients and 6 controls. The frequency of rare variants was significantly higher in the patient group than in the control group (18/356 versus 6/386, odds ratio = 3.37, P = 0.007). All the 12 rare variants at the 5' regulatory region were only detected in 7 patients, but not in any of the controls (7/356 versus 0/386, Fisher's exact test, P = 0.006). Two patients carried multiple rare variants. Family studies showed that most of these rare variants were transmitted from their parents. Reporter gene assays revealed that four rare variants at the 5' regulatory region and 1 at exon 1a untranslated region had elevated reporter gene activities compared to two wild type alleles.
Conclusions: Our data suggest rare variants of GABRB3 might be associated with ASD, and increased GABRB3 expression may contribute to the pathogenesis of ASD in some patients.
C1 [Chen, Chia-Hsiang; Wu, Yu-Yu] Chang Gung Mem Hosp Linkou, Dept Psychiat, Taoyuan, Taiwan.
[Chen, Chia-Hsiang] Chang Gung Univ, Dept & Grad Inst Biomed Sci, Taoyuan, Taiwan.
[Chen, Chia-Hsiang; Chiu, Yen-Nan; Tsai, Wen-Che; Gau, Susan Shur-Fen] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan.
[Chen, Chia-Hsiang; Chiu, Yen-Nan; Tsai, Wen-Che; Gau, Susan Shur-Fen] Coll Med, Taipei 10002, Taiwan.
[Huang, Chia-Chun] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan.
[Cheng, Min-Chih] Yuli Vet Hosp, Yuli Mental Hlth Res Ctr, Dept Psychiat, Hualien, Taiwan.
[Liu, Shih-Kai] Minist Hlth & Welf, Taoyaun Psychiat Ctr, Dept Child & Adolescent Psychiat, Taoyuan, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Taipei 10764, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.
RP Gau, SSF (reprint author), Natl Taiwan Univ Hosp, Dept Psychiat, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM gaushufe@ntu.edu.tw
FU National Science Council [NSC96-3112-B-002-033, NSC97-3112-B-002-009,
NSC98-3112-B-002-004, NSC 99-3112-B-002-036]; National Taiwan University
[10R81918-03, 101R892103, 102R892103]
FX This work was supported by grants from National Science Council
(NSC96-3112-B-002-033, NSC97-3112-B-002-009, NSC98-3112-B-002-004, and
NSC 99-3112-B-002-036 to SSG) and National Taiwan University (AIM for
Top University Excellent Research Project: 10R81918-03, 101R892103,
102R892103 to SSG). This work was approved by the Research Ethics
Committee of National Taiwan University Hospital (approved number:
9561709027), Taipei, Taiwan; Chang Gung Memorial Hospital (approved
number, 93-6244), Taoyuan, Taiwan; and Taoyuan Mental Hospital (approved
number C20060905), Taoyuan, Taiwan.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Anitha A, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-12
Ashley-Koch AE, 2006, ANN HUM GENET, V70, P281, DOI 10.1111/j.1469-1809.2006.00253.x
BAILEY A, 1995, PSYCHOL MED, V25, P63
Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
Battaglia A, 2008, ORPHANET J RARE DIS, V3, DOI 10.1186/1750-1172-3-30
Buhr A, 2002, HUM GENET, V111, P154, DOI 10.1007/s00439-002-0766-7
Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
Chien YL, 2011, COMPR PSYCHIAT, V52, P195, DOI 10.1016/j.comppsych.2010.03.009
Chien YL, 2011, PROG NEURO-PSYCHOPH, V35, P1512, DOI 10.1016/j.pnpbp.2011.04.010
Collinson N, 2002, J NEUROSCI, V22, P5572
Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832
Crestani F, 2002, P NATL ACAD SCI USA, V99, P8980, DOI 10.1073/pnas.142288699
CULIAT CT, 1994, P NATL ACAD SCI USA, V91, P2815, DOI 10.1073/pnas.91.7.2815
Delahanty RJ, 2011, MOL PSYCHIATR, V16, P86, DOI 10.1038/mp.2009.118
DeLorey TM, 1998, J NEUROSCI, V18, P8505
Delorey TM, 2005, INT REV NEUROBIOL, V71, P359, DOI 10.1016/S0074-7742(05)71015-1
DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009
Fatemi SH, 2014, J AUTISM DEV DISORD
Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Gabriel SB, 2002, SCIENCE, V296, P2225, DOI 10.1126/science.1069424
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Gau SSF, 2013, RES AUTISM SPECT DIS, V7, P349, DOI 10.1016/j.rasd.2012.10.004
Gau SSF, 2011, RES AUTISM SPECT DIS, V5, P809, DOI 10.1016/j.rasd.2010.09.010
Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014
Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
Kim SA, 2006, NEUROPSYCHOBIOLOGY, V54, P160, DOI 10.1159/000098651
Lachance-Touchette P, 2010, EPILEPSIA, V51, P1894, DOI 10.1111/j.1528-1167.2010.02642.x
Lau WYP, 2013, RES DEV DISABIL, V34, P294, DOI 10.1016/j.ridd.2012.08.005
LEWONTIN RC, 1964, GENETICS, V49, P49
Liu JJ, 2001, AM J HUM GENET, V69, P327, DOI 10.1086/321980
Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
Macdonald RL, 2012, JASPERS BASIC MECH E
Maestrini E, 1999, AM J MED GENET, V88, P492, DOI 10.1002/(SICI)1096-8628(19991015)88:5<492::AID-AJMG11>3.0.CO;2-X
Martin ER, 2000, AM J MED GENET, V96, P43, DOI 10.1002/(SICI)1096-8628(20000207)96:1<43::AID-AJMG9>3.0.CO;2-3
McCauley JL, 2004, AM J MED GENET B, V131B, P51, DOI 10.1002/ajmg.b.30038
Menold MM, 2001, J NEUROGENET, V15, P245
Mori T, 2012, BRAIN DEV-JPN, V34, P648, DOI 10.1016/j.braindev.2011.10.007
Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
Nurmi EL, 2003, J AM ACAD CHILD PSY, V42, P856, DOI 10.1097/01.CHI.0000046868.56865.0F
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Pizzarelli R, 2011, NEURAL PLAST, DOI 10.1155/2011/297153
Salmon B, 1999, AM J MED GENET, V88, P551, DOI 10.1002/(SICI)1096-8628(19991015)88:5<551::AID-AJMG21>3.0.CO;2-#
Scoles HA, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-19
Sesarini CV, 2014, AUTISM RES, V7, P162, DOI 10.1002/aur.1353
Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846
Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
Shi YY, 2005, CELL RES, V15, P97
Sutcliffe JS, 2003, J AM ACAD CHILD PSY, V42, P253, DOI 10.1097/01.CHI.0000037006.34553.D2
Tanaka M, 2012, EPILEPSIA, V53, P1450, DOI 10.1111/j.1528-1167.2012.03572.x
Tanaka M, 2012, JASPERS BASIC MECH E
Tanaka M, 2008, AM J HUM GENET, V82, P1249, DOI 10.1016/j.ajhg.2008.04.020
Tavassoli T, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-6
Tochigi M, 2007, J HUM GENET, V52, P985, DOI 10.1007/s10038-007-0207-5
Urak L, 2006, HUM MOL GENET, V15, P2533, DOI 10.1093/hmg/ddl174
Warrier V, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-48
Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62
Yoo HK, 2009, YONSEI MED J, V50, P304, DOI 10.3349/ymj.2009.50.2.304
Zafeiriou DI, 2013, AM J MED GENET B, V162B, P327, DOI 10.1002/ajmg.b.32152
NR 68
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUN 25
PY 2014
VL 5
AR 36
DI 10.1186/2040-2392-5-36
PG 13
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AK8HY
UT WOS:000338669700001
PM 24999380
ER
PT J
AU Carver, AR
Andrikopoulou, M
Lei, J
Tamayo, E
Gamble, P
Hou, ZP
Zhang, JY
Mori, S
Saade, GR
Costantine, MM
Burd, I
AF Carver, Alissa R.
Andrikopoulou, Maria
Lei, Jun
Tamayo, Esther
Gamble, Phyllis
Hou, Zhipeng
Zhang, Jiangyang
Mori, Susumu
Saade, George R.
Costantine, Maged M.
Burd, Irina
TI Maternal Pravastatin Prevents Altered Fetal Brain Development in a
Preeclamptic CD-1 Mouse Model
SO PLOS ONE
LA English
DT Article
ID COA REDUCTASE INHIBITORS; NEONATAL HYPOXIA-ISCHEMIA; AUTISM SPECTRUM
DISORDER; SEX-DIFFERENCES; IN-UTERO; CARDIOVASCULAR FUNCTION; PRENATAL
EXPOSURE; GENE-TRANSFER; BIRTH-WEIGHT; MURINE MODEL
AB Objective: Using an animal model, we have previously shown that preeclampsia results in long-term adverse neuromotor outcomes in the offspring, and this phenotype was prevented by antenatal treatment with pravastatin. This study aims to localize the altered neuromotor programming in this animal model and to evaluate the role of pravastatin in its prevention.
Materials and Methods: For the preeclampsia model, pregnant CD-1 mice were randomly allocated to injection of adenovirus carrying sFlt-1 or its control virus carrying mFc into the tail vein. Thereafter they received pravastatin (sFlt-1-pra "experimental group'') or water (sFlt-1 "positive control'') until weaning. The mFc group ("negative control'') received water. Offspring at 6 months of age were sacrificed, and whole brains underwent magnetic resonance imaging (MRI). MRIs were performed using an 11.7 Tesla vertical bore MRI scanner. T2 weighted images were acquired to evaluate the volumes of 28 regions of interest, including areas involved in adaptation and motor, spatial and sensory function. Cytochemistry and cell quantification was performed using neuron-specific Nissl stain. One-way ANOVA with multiple comparison testing was used for statistical analysis.
Results: Compared with control offspring, male sFlt-1 offspring have decreased volumes in the fimbria, periaquaductal gray, stria medullaris, and ventricles and increased volumes in the lateral globus pallidus and neocortex; however, female sFlt-1 offspring showed increased volumes in the ventricles, stria medullaris, and fasciculus retroflexus and decreased volumes in the inferior colliculus, thalamus, and lateral globus pallidus. Neuronal quantification via Nissl staining exhibited decreased cell counts in sFlt-1 offspring neocortex, more pronounced in males. Prenatal pravastatin treatment prevented these changes.
Conclusion: Preeclampsia alters brain development in sex-specific patterns, and prenatal pravastatin therapy prevents altered neuroanatomic programming in this animal model.
C1 [Carver, Alissa R.; Tamayo, Esther; Gamble, Phyllis; Saade, George R.; Costantine, Maged M.] Univ Texas Med Branch, Dept Obstet & Gynecol, Div Maternal Fetal Med, Galveston, TX 77555 USA.
[Andrikopoulou, Maria; Lei, Jun; Burd, Irina] Johns Hopkins Univ, Dept Gynecol & Obstet, Integrated Res Ctr Fetal Med, Div Maternal Fetal Med, Baltimore, MD USA.
[Hou, Zhipeng; Zhang, Jiangyang; Mori, Susumu] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA.
RP Carver, AR (reprint author), Univ Texas Med Branch, Dept Obstet & Gynecol, Div Maternal Fetal Med, Galveston, TX 77555 USA.
EM arcarver@utmb.edu
FU NICHD [K08 HD073315]; NIH [RO1 EB003543]; Brain Science Institute, Johns
Hopkins
FX This work was supported by NICHD K08 HD073315 (www.nichd.nih.gov), NIH
RO1 EB003543 (www.nih.gov) and grant support from Brain Science
Institute, Johns Hopkins (www.brainscienceinstitute.org). The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
CR American College of Obstetricians and Gynecologists, 2002, OBSTET GYNECOL, V99, P159
Bajo VM, 2013, FRONT NEURAL CIRCUIT, V6, DOI 10.3389/fncir.2012.00114
Beckmann H, 1999, EUR ARCH PSY CLIN N, V249, P44
Brosda J, 2011, NEUROBIOL DIS, V44, P239, DOI 10.1016/j.nbd.2011.07.008
Bushnell CD, 2006, STROKE, V37, P1427, DOI 10.1161/01.STR.0000221315.60282.ca
Bytautiene E, 2010, AM J PHYSIOL-HEART C, V298, pH189, DOI 10.1152/ajpheart.00792.2009
Carver AR, 2014, INT J DEV NEUROSCI, V33, P33, DOI 10.1016/j.ijdevneu.2013.11.004
Cassel JC, 1997, PROG NEUROBIOL, V51, P663, DOI 10.1016/S0301-0082(97)00009-9
Chagraoui H, 2001, EUR CYTOKINE NETW, V12, P561
Chau V, 2013, NEUROLOGY, V81, P2082, DOI 10.1212/01.wnl.0000437298.43688.b9
Costantine M, 2008, AM J OBSTET GYNECOL, V199, pS40, DOI 10.1016/j.ajog.2008.09.117
Costantine MM, 2013, OBSTET GYNECOL, V121, P349, DOI [http://10.1097/AOG.0b013e31827d8ad5, 10.1097/AOG.0b013e31827d8ad5]
Costantine MM, 2010, OBSTET GYNECOL, V116, P114, DOI 10.1097/AOG.0b013e3181e10ebd
Dada T, 2014, BRAIN BEHAV IMMUN, V38, P142, DOI 10.1016/j.bbi.2014.01.014
Davies LA, 2008, MOL THER, V16, P812, DOI 10.1038/mt.2008.25
Edison RJ, 2004, AM J MED GENET A, V131A, P287, DOI 10.1002/ajmg.a.30386
Ehrenstein V, 2009, AM J EPIDEMIOL, V170, P1025, DOI 10.1093/aje/kwp223
Elahi MM, 2008, HYPERTENSION, V51, P939, DOI 10.1161/HYPERTENSIONAHA.107.100982
ELLISON G, 1994, BRAIN RES REV, V19, P223, DOI 10.1016/0165-0173(94)90012-4
Folsom TD, 2013, NEUROPHARMACOLOGY, V68, P122, DOI 10.1016/j.neuropharm.2012.08.015
Fox KA, 2011, AM J OBSTET GYNECOL, V205
Gabory A, 2013, BIOL SEX DIFFER, V4, DOI 10.1186/2042-6410-4-5
Gebhart GF, 2004, NEUROSCI BIOBEHAV R, V27, P729, DOI 10.1016/j.neubiorev.2003.11.008
Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
Golan MH, 2009, NEUROPHARMACOLOGY, V57, P511, DOI 10.1016/j.neuropharm.2009.07.028
Gutierrez J, 2012, ARCH INTERN MED, V172, P909, DOI 10.1001/archinternmed.2012.2145
Hatanaka T, 2000, CLIN PHARMACOKINET, V39, P397, DOI 10.2165/00003088-200039060-00002
Herson PS, 2013, TRANSL STROKE RES, V4, P413, DOI 10.1007/s12975-012-0238-x
Hill CA, 2012, NEUROL RES INT, V2012, DOI DOI 10.1155/2012/867531
Hoglund K, 2007, CNS DRUGS, V21, P449
Huang H, 2013, CEREB CORTE IN PRESS
Infante SK, 2013, INT J DEV NEUROSCI, V31, P398, DOI 10.1016/j.ijdevneu.2013.02.003
Ingalhalikar M, 2014, P NATL ACAD SCI USA, V111, P823, DOI 10.1073/pnas.1316909110
Kazmin Aleksey, 2007, J Obstet Gynaecol Can, V29, P906
Kikuchi N, 2002, GENE THER, V9, P1529, DOI 10.1038/sj.gt.3301818
Kikuchi R, 2004, J PHARMACOL EXP THER, V311, P1147, DOI 10.1124/jpet.104.071621
KLOOSTER J, 1995, BRAIN RES, V688, P34, DOI 10.1016/0006-8993(95)00497-E
Kumar A, 2012, BRAIN RES, V1471, P13, DOI 10.1016/j.brainres.2012.06.050
Kumasawa K, 2011, P NATL ACAD SCI USA, V108, P1451, DOI 10.1073/pnas.1011293108
Leung KK, 2013, NEUROLOGY, V80, P648, DOI 10.1212/WNL.0b013e318281ccd3
Levine RJ, 2004, NEW ENGL J MED, V350, P672, DOI 10.1056/NEJMoa031884
Li AP, 2010, NEUROL RES, V32, P945, DOI 10.1179/016164110X12670144737774
Li H, 2005, ANN NEUROL, V58, P317, DOI 10.1002/ana.20538
Liao JK, 2005, AM J CARDIOL, V96, p24F, DOI 10.1016/j.amjcard.2005.06.009
Lu F, 2007, AM J OBSTET GYNECOL, V196
Lu F, 2007, AM J OBSTET GYNECOL, V197
Machon RA, 1997, ARCH GEN PSYCHIAT, V54, P322
Mahmood A, 2009, NEUROSURGERY, V65, P187, DOI 10.1227/01.NEU.0000343540.24780.D6
Mann JR, 2010, J AUTISM DEV DISORD, V40, P548, DOI 10.1007/s10803-009-0903-4
Mann JR, 2011, J ATTEN DISORD, V15, P667, DOI 10.1177/1087054710370566
Many A, 2003, HYPERTENS PREGNANCY, V22, P25, DOI 10.1081/PRG-120016791
Maynard SE, 2003, J CLIN INVEST, V111, P649, DOI 10.1172/JCI200317189
McCarthy MM, 2009, J NEUROSCI, V29, P12815, DOI 10.1523/JNEUROSCI.3331-09.2009
McDonnold M, 2014, AM J OBSTET GYNECOL, V210
McDonnold M, 2013, AM J OBSTET GYNECOL, V208, pS28
Mooradian AD, 2005, DIABETES, V54, P2977, DOI 10.2337/diabetes.54.10.2977
Movsas TZ, 2013, J PEDIATR-US, V163, P73, DOI 10.1016/j.jpeds.2012.12.084
Nanovskaya TN, 2013, AM J OBSTET GYNECOL, V209, p373 e1
Ofori B, 2007, BRIT J CLIN PHARMACO, V64, P496, DOI 10.1111/j.1365-2125.2007.02905.x
Paintlia AS, 2009, GLIA, V57, P182, DOI 10.1002/glia.20745
Paul MJ, 2011, EUR J NEUROSCI, V34, P478, DOI 10.1111/j.1460-9568.2011.07762.x
Paxino G, 2001, MOUSE BRAIN STEREOTA
Peacock JL, 2012, PEDIATR RES, V71, P305, DOI 10.1038/pr.2011.50
Petersen EE, 2008, AM J MED GENET A, V146A, P2701, DOI 10.1002/ajmg.a.32493
Prevosto Vincent, 2013, Front Syst Neurosci, V7, P56, DOI 10.3389/fnsys.2013.00056
Redman CW, 2005, SCIENCE, V308, P1592, DOI 10.1126/science.1111726
Saad AF, 2014, REPROD SCI, V21, P138, DOI 10.1177/1933719113492207
Sacco RL, 2005, NAT CLIN PRACT CARD, V2, P576, DOI 10.1038/ncpcardio0348
Senoo M, 2000, MOL GENET METAB, V69, P269, DOI 10.1006/mgme.2000.2984
Sierra S, 2011, J ALZHEIMERS DIS, V23, P307, DOI 10.3233/JAD-2010-101179
Singh J, 2011, HYPERTENSION, V58, P716, DOI 10.1161/HYPERTENSIONAHA.111.175919
Stephenson-Jones M, 2013, P NATL ACAD SCI USA, V110, pE3670, DOI 10.1073/pnas.1314815110
Suren P, 2012, PEDIATRICS, V130, pE152, DOI 10.1542/peds.2011-3217
Taguchi N, 2008, REPROD TOXICOL, V26, P175, DOI 10.1016/j.reprotox.2008.06.009
Wagner AK, 2005, CRIT CARE MED, V33, P407, DOI 10.1097/01.CCM.0000153931.23488.DD
Wei K, 2007, J MOL MED, V86, P161
Westera J, 2011, AM J OBSTET GYNECOL, V204
Whitehouse AJO, 2012, PAEDIATR PERINAT EP, V26, P101, DOI 10.1111/j.1365-3016.2011.01257.x
Wilde EA, 2005, J NEUROTRAUM, V22, P333, DOI 10.1089/neu.2005.22.333
Winterfeld U, 2013, BJOG-INT J OBSTET GY, V120, P463, DOI 10.1111/1471-0528.12066
Zarek J, 2013, PLACENTA, V34, P719, DOI 10.1016/j.placenta.2013.05.002
Zhan Y, 2014, NAT NEUROSCI, V17, P400, DOI 10.1038/nn.3641
Zhang JY, 2010, NEUROIMAGE, V49, P2340, DOI 10.1016/j.neuroimage.2009.10.027
Zhu CL, 2006, J NEUROCHEM, V96, P1016, DOI 10.1111/j.1471-4159.2005.03639.x
NR 84
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 25
PY 2014
VL 9
IS 6
AR e100873
DI 10.1371/journal.pone.0100873
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK8WO
UT WOS:000338709500093
PM 24963809
ER
PT J
AU Austin, G
Groppe, K
Elsner, B
AF Austin, Gina
Groppe, Karoline
Elsner, Birgit
TI The reciprocal relationship between executive function and theory of
mind in middle childhood: a 1-year longitudinal perspective
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE executive function; theory of mind; longitudinal; middle childhood;
attention shifting; inhibition; working memory updating
ID INDIVIDUAL-DIFFERENCES; INHIBITORY CONTROL; CHILDRENS THEORY;
WORKING-MEMORY; BELIEF; PRESCHOOLERS; AUTISM; ADULTS; TASKS; LINKS
AB There is robust evidence showing a link between executive function (EF) and theory of mind (ToM) in 3-to 5-year-olds. However, it is unclear whether this relationship extends to middle childhood. In addition, there has been much discussion about the nature of this relationship. Whereas some authors claim that ToM is needed for EF, others argue that ToM requires EF. To date, however, studies examining the longitudinal relationship between distinct sub components of EF [i.e., attention shifting, working memory (WM) updating, inhibition] and ToM in middle childhood are rare. The present study examined (1) the relationship between three EF subcomponents (attention shifting, WM updating, inhibition) and ToM in middle childhood, and (2) the longitudinal reciprocal relationships between the EF subcomponents and ToM across a 1-year period. EF and ToM measures were assessed experimentally in a sample of 1,657 children (aged 6-11 years) at time point one (t1) and 1 year later at time point two (t2). Results showed that the concurrent relationships between all three EF subcomponents and ToM pertained in middle childhood at t1 and t2, respectively, even when age, gender, and fluid intelligence were partialle dout. Moreover, cross-lagged structural equation modeling (again, controlling for age, gender, and fluid intelligence, as well as for the earlier levels of the target variables), revealed partial support for the view that early ToM predictslater EF, but stronger evidence for the assumption that early EF predictslater ToM. The latter was found for attention shifting and WM updating, but not for inhibition. This reveals the importance of studying the exact interplay of ToM and EF across childhood development, especially with regard to different EF subcomponents. Most likely, understanding others' mental states at different levels of perspective-taking requires specific EF subcomponents, suggesting developmental change in the relations between EF and ToM across childhood.
C1 [Austin, Gina; Groppe, Karoline; Elsner, Birgit] Univ Potsdam, Dept Psychol, D-14476 Potsdam, Germany.
RP Austin, G (reprint author), Univ Potsdam, Dept Psychol, Karl Liebknecht St 24-25, D-14476 Potsdam, Germany.
EM gina.austin@uni-potsdam.de
CR Archibald SJ, 1999, CHILD NEUROPSYCHOL, V5, P115, DOI 10.1076/chin.5.2.115.3167
Benson JE, 2013, DEV PSYCHOL, V49, P1615, DOI 10.1037/a0031056
Bradley RH, 2002, ANNU REV PSYCHOL, V53, P371, DOI 10.1146/annurev.psych.53.100901.135233
Calderon J, 2010, DEV MED CHILD NEUROL, V52, P1139, DOI 10.1111/j.1469-8749.2010.03735.x
Carlson SM, 2001, CHILD DEV, V72, P1032, DOI 10.1111/1467-8624.00333
Carlson SM, 2004, DEV PSYCHOL, V40, P1105, DOI 10.1037/0012-1649.40.6.1105
Carruthers P., 1996, THEORIES THEORIES MI, P257
Charman T., 2001, J EMOT BEHAV DISORD, V6, P31, DOI [10.1080/13632750100507654, DOI 10.1080/13632750100507654]
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
C-Y Yu, 2002, EVALUATING CUTOFF CR
DAVIS HL, 1995, AUST J PSYCHOL, V47, P25, DOI 10.1080/00049539508258765
Doherty M. J., 2009, THEORY MIND CHILDREN
Farrant BM, 2012, CHILD DEV, V83, P223, DOI 10.1111/j.1467-8624.2011.01681.x
Flynn E, 2004, DEVELOPMENTAL SCI, V7, P103, DOI 10.1111/j.1467-7687.2004.00326.x
Flynn E, 2007, INFANT CHILD DEV, V16, P53, DOI 10.1002/icd.500
Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692
Frye D, 1995, COGNITIVE DEV, V10, P483, DOI 10.1016/0885-2014(95)90024-1
Garnham WA, 2001, DEVELOPMENTAL SCI, V4, P94, DOI 10.1111/1467-7687.00153
Geiser C., 2010, DATENANALYSE MPLUS, DOI [10.1007/978-3-531-92042-9, DOI 10.1007/78-3-531-92042-9]
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Henning A., 2012, EXTENDED THEORY OF M
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Hollebrandse B, 2014, SYNTHESE, V191, P321, DOI 10.1007/s11229-012-0169-9
Hughes C, 2011, INFANT CHILD DEV, V20, P251, DOI 10.1002/icd.736
Hughes C, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P255
Hughes C, 1998, BRIT J DEV PSYCHOL, V16, P233
HUGHES C, 1993, DEV PSYCHOL, V29, P498, DOI 10.1037/0012-1649.29.3.498
Hughes C, 1998, DEV PSYCHOL, V34, P1326, DOI 10.1037/0012-1649.34.6.1326
Hughes C, 2007, DEV PSYCHOL, V43, P1447, DOI 10.1037/0012-1649.43.6.1447
Jahromi LB, 2008, MERRILL PALMER QUART, V54, P125, DOI 10.1353/mpq.2008.0007
Keenan T, 1998, AUST J PSYCHOL, V50, P76, DOI 10.1080/00049539808257537
Kerr A, 2004, BRAIN COGNITION, V55, P148, DOI 10.1016/s0278-2626(03)00275-6
Kloo D, 2003, CHILD DEV, V74, P1823, DOI 10.1046/j.1467-8624.2003.00640.x
Lalonde CE, 2002, NEW IDEAS PSYCHOL, V20, P163, DOI 10.1016/S0732-118X(02)00007-7
McAlister A, 2007, COGNITIVE DEV, V22, P258, DOI 10.1016/j.cogdev.2006.10.009
Miller SA, 2009, PSYCHOL BULL, V135, P749, DOI 10.1037/a0016854
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
Moses LJ, 2001, CHILD DEV, V72, P688, DOI 10.1111/1467-8624.00306
Muller U, 2012, J EXP CHILD PSYCHOL, V111, P331, DOI 10.1016/j.jecp.2011.08.014
Muthen L. K., 1998, MPLUS USERS GUIDE
Pacherie E., 1997, AUTISM EXECUTIVE DIS, P215
Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7
Perner J, 1999, TRENDS COGN SCI, V3, P337, DOI 10.1016/S1364-6613(99)01362-5
Perner J, 2002, INFANT CHILD DEV, V11, P141, DOI 10.1002/icd.302
Perner J., 2000, UNDERSTANDING OTHER, P150
Perner J, 1998, LANGUAGE THOUGHT, P270
Petermann F., 2007, HAMBURG WECHSLER INT
Putko A, 2009, POL PSYCHOL B, V40, P156, DOI [10.2478/s10059-009-0010-6, DOI 10.2478/S10059-009-0010-6]
Razza RA, 2009, J APPL DEV PSYCHOL, V30, P332, DOI 10.1016/j.appdev.2008.12.020
Rothlisberger M, 2010, Z ENTWICKL PADAGOGIS, V42, P99, DOI 10.1026/0049-8637/a000010
Russell J., 1996, AGENCY ITS ROLE MENT
Russell J., 1997, AUTISM EXECUTIVE DIS, P256
Sabbagh MA, 2006, PSYCHOL SCI, V17, P74, DOI 10.1111/j.1467-9280.2005.01667.x
Schermelleh-Engel K., 2003, METHODS PSYCHOL RES, V8, P23
Schneider W, 2005, YOUNG CHILDREN'S COGNITIVE DEVELOPMENT: INTERRELATIONSHIPS AMONG EXECUTIVE FUNCTIONING, WORKING MEMORY, VERBAL ABILITY, AND THEORY OF MIND, P259
Sebastian CL, 2012, SOC COGN AFFECT NEUR, V7, P53, DOI 10.1093/scan/nsr023
Stevens J., 2001, APPL MULTIVARIATE ST
TagerFlusberg H, 1997, DEV NEUROPSYCHOL, V13, P487
Vetter NC, 2013, DEV NEUROPSYCHOL, V38, P114, DOI 10.1080/87565641.2012.733786
Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022
WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
Yang J, 2009, CHILD PSYCHIAT HUM D, V40, P169, DOI 10.1007/s10578-008-0119-4
Zelazo PD, 2012, CHILD DEV PERSPECT, V6, P354, DOI 10.1111/j.1750-8606.2012.00246.x
Zimmermann P., 2002, KITAP TESTBATTERIE A
NR 65
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUN 24
PY 2014
VL 5
AR 655
DI 10.3389/fpsyg.2014.00655
PG 11
WC Psychology, Multidisciplinary
SC Psychology
GA AK9CG
UT WOS:000338724500001
PM 25009527
ER
PT J
AU Kessler, K
Cao, LY
O'Shea, KJ
Wang, HF
AF Kessler, Klaus
Cao, Liyu
O'Shea, Kieran J.
Wang, Hongfang
TI A cross-culture, cross-gender comparison of perspective taking
mechanisms
SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE perspective taking; embodied transformation; line of sight; culture
differences; gender differences; egocentric bias
ID SOCIAL COGNITION; SPECIES FOLLOW; CHILDREN; HUMANS; GAZE; DISSOCIATION;
PERCEPTION; AUTISM; ADULTS; SKILLS
AB Being able to judge another person's visuo-spatial perspective is an essential social skill, hence we investigated the generalizability of the involved mechanisms across cultures and genders. Developmental, cross-species, and our own previous research suggest that two different forms of perspective taking can be distinguished, which are subserved by two distinct mechanisms. The simpler form relies on inferring another's line-of-sight, whereas the more complex form depends on embodied transformation into the other's orientation in form of a simulated body rotation. Our current results suggest that, in principle, the same basic mechanisms are employed by males and females in both, East-Asian (EA; Chinese) and Western culture. However, we also confirmed the hypothesis that Westerners show an egocentric bias, whereas EAs reveal an other-oriented bias. Furthermore, Westerners were slower overall than EAs and showed stronger gender differences in speed and depth of embodied processing. Our findings substantiate differences and communalities in social cognition mechanisms across genders and two cultures and suggest that cultural evolution or transmission should take gender as a modulating variable into account.
C1 [Kessler, Klaus; Cao, Liyu; O'Shea, Kieran J.; Wang, Hongfang] Univ Glasgow, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland.
[Kessler, Klaus; Wang, Hongfang] Aston Univ, Aston Brain Ctr, Birmingham B4 7ET, W Midlands, England.
RP Kessler, K (reprint author), Univ Glasgow, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland.
EM k.kessler@aston.ac.uk
FU ESRC [RES-000-22-4325]
FX This research was supported by ESRC funding to K.K. (RES-000-22-4325).
CR Baker Colin, 2001, FDN BILINGUAL ED BIL, V3rd
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Barr DJ, 2013, FRONT HUM NEUROSCI, V7, P822, DOI [10.3389/fnhum.2013.00822, DOI 10.3389/FNHUM.2013.00822]
Braithwaite JJ, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00719
Brauer J, 2005, J COMP PSYCHOL, V119, P145, DOI 10.1037/0735-7036.119.2.145
Brauer J, 2006, J COMP PSYCHOL, V120, P38, DOI 10.1037/0735-7036.120.1.38
Brauer J, 2007, ANIM COGN, V10, P439, DOI 10.1007/s10071-007-0088-1
Bugnyar T, 2004, P ROY SOC B-BIOL SCI, V271, P1331, DOI 10.1098/rspb.2004.2738
Call J, 2008, TRENDS COGN SCI, V12, P187, DOI 10.1016/j.tics.2008.02.010
Call J, 2003, J COMP PSYCHOL, V117, P257, DOI 10.1037/0735-7036.117.3.257
Chua HF, 2005, P NATL ACAD SCI USA, V102, P12629, DOI 10.1073/pnas.0506162102
Emery NJ, 2009, ANNU REV PSYCHOL, V60, P87, DOI 10.1146/annurev.psych.60.110707.163526
FLAVELL JH, 1981, DEV PSYCHOL, V17, P99, DOI 10.1037/0012-1649.17.1.99
Frith CD, 2007, CURR BIOL, V17, pR724, DOI 10.1016/j.cub.2007.05.068
Grabowski J., 1999, SPAT COGN COMPUT, V1, P349, DOI DOI 10.1023/A:1010031428440
GZESH SM, 1985, CHILD DEV, V56, P1204, DOI 10.1111/j.1467-8624.1985.tb00189.x
Hamilton AFD, 2009, COGNITION, V113, P37, DOI 10.1016/j.cognition.2009.07.007
Hegarty M, 2005, CAMBRIDGE HDB VISUOS, P121, DOI DOI 10.1017/CBO9780511610448
Henrich J, 1998, EVOL HUM BEHAV, V19, P215, DOI 10.1016/S1090-5138(98)00018-X
Kessler K, 2012, SPAT COGN COMPUT, V12, P133, DOI 10.1080/13875868.2011.634533
Kessler K, 2010, FRONT PSYCHOL, V1, DOI [10.3389/fphys.2010.00213, 10.3389/fpsyg.2010.00213]
Kessler K, 2010, COGNITION, V114, P72, DOI 10.1016/j.cognition.2009.08.015
Keysar B, 2003, COGNITION, V89, P25, DOI 10.1016/S0010-0277(03)00064-7
Kozhevnikov M, 2001, MEM COGNITION, V29, P745, DOI 10.3758/BF03200477
MARKUS HR, 1991, PSYCHOL REV, V98, P224, DOI 10.1037/0033-295X.98.2.224
May M, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00549
McGuire LMM, 2009, NAT NEUROSCI, V12, P1056, DOI 10.1038/nn.2357
Michelon P, 2006, PERCEPT PSYCHOPHYS, V68, P327, DOI 10.3758/BF03193680
Moll H, 2006, BRIT J DEV PSYCHOL, V24, P603, DOI 10.1348/026151005X55370
Pack Adam A., 2006, Aquatic Mammals, V32, P443, DOI 10.1578/AM.32.4.2006.443
Piaget J, 1956, REPRESENTATION ESPAC
Scheumann M, 2004, ANIM COGN, V7, P224, DOI 10.1007/s10071-004-0216-0
Surtees A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00698
Surtees ADR, 2012, BRIT J DEV PSYCHOL, V30, P75, DOI 10.1111/j.2044-835X.2011.02063.x
Tomasello M., 2005, BEHAV BRAIN SCI, V28, P691, DOI [10.1017/S0140525X05000129, DOI 10.1017/S0140525X05000129)]
Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
Tomasello M, 1998, ANIM BEHAV, V55, P1063, DOI 10.1006/anbe.1997.0636
Varnum MEW, 2010, CURR DIR PSYCHOL SCI, V19, P9, DOI 10.1177/0963721409359301
Wang RXF, 2006, PSYCHON B REV, V13, P281, DOI 10.3758/BF03193844
Wu SL, 2007, PSYCHOL SCI, V18, P600, DOI 10.1111/j.1467-9280.2007.01946.x
Zacks Jeffrey M, 2005, Behav Cogn Neurosci Rev, V4, P96, DOI 10.1177/1534582305281085
NR 42
TC 2
Z9 2
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8452
EI 1471-2954
J9 P ROY SOC B-BIOL SCI
JI Proc. R. Soc. B-Biol. Sci.
PD JUN 22
PY 2014
VL 281
IS 1785
AR 20140388
DI 10.1098/rspb.2014.0388
PG 9
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology
GA AH0LT
UT WOS:000335812100020
PM 24807256
ER
PT J
AU Zerbo, O
Yoshida, C
Grether, JK
Van de Water, J
Ashwood, P
Delorenze, GN
Hansen, RL
Kharrazi, M
Croen, LA
AF Zerbo, Ousseny
Yoshida, Cathleen
Grether, Judith K.
Van de Water, Judy
Ashwood, Paul
Delorenze, Gerald N.
Hansen, Robin L.
Kharrazi, Marty
Croen, Lisa A.
TI Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder:
the Early Markers for Autism (EMA) study: a case-control study
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Newborn; Cytokines; Chemokines; Autism spectrum disorders
ID HISTORIC BIRTH COHORT; IMMUNE-RESPONSE; CHILDREN; BRAIN; DYSFUNCTION;
PREGNANCY; IMMUNOGLOBULIN; PREVALENCE; ACTIVATION; INFECTION
AB Background: Biologic markers of infection and inflammation have been associated with Autism Spectrum Disorders (ASD) but prior studies have largely relied on specimens taken after clinical diagnosis. Research on potential biologic markers early in neurodevelopment is required to evaluate possible causal pathways and screening profiles.
Objective: To investigate levels of cytokines and chemokines in newborn blood specimens as possible early biologic markers for autism.
Methods: We conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, California, USA. The study population included children ascertained from the California Department of Developmental Services with Autism Spectrum Disorder (ASD, n = 84), or developmental delay but not ASD (DD, n = 49), and general population controls randomly sampled from the birth certificate files and frequency matched to ASD cases on sex, birth month and birth year (GP, n = 159). Cytokine and chemokine concentrations were measured in archived neonatal blood specimens collected for routine newborn screening.
Results: Cytokines were not detected in the vast majority of newborn samples regardless of case or control status. However, the chemokine monocyte chemotactic protein-1 (MCP-1) was elevated and the chemokine Regulated upon Activation Normal T-Cell Expressed and Secreted (RANTES) was decreased in ASD cases compared to GP controls. The chemokines macrophage inflammatory protein-1alpha (MIP-1 alpha) and RANTES were decreased in children with DD compared to GP controls.
Conclusion: Measurement of immune system function in the first few days of life may aid in the early identification of abnormal neurodevelopment and shed light on the biologic mechanisms underlying normal neurodevelopment.
C1 [Zerbo, Ousseny; Yoshida, Cathleen; Grether, Judith K.; Delorenze, Gerald N.; Croen, Lisa A.] Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
[Grether, Judith K.; Kharrazi, Marty] Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA 94804 USA.
[Van de Water, Judy] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA.
[Van de Water, Judy; Ashwood, Paul; Hansen, Robin L.] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
[Ashwood, Paul] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA.
[Hansen, Robin L.] Dept Pediat, Sacramento, CA 95817 USA.
RP Zerbo, O (reprint author), Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
EM ousseny.x.zerbo@kp.org
FU National Institute of Environmental Health Sciences [3R01ES016669];
National Institute of Mental Health [5R01MH072565]
FX The study was supported by grants 3R01ES016669 from National Institute
of Environmental Health Sciences; 5R01MH072565 from the National
Institute of Mental Health.
CR Abdallah MW, 2013, CYTOKINE, V61, P370, DOI 10.1016/j.cyto.2012.11.015
Abdallah MW, 2012, J NEUROIMMUNOL, V252, P75, DOI 10.1016/j.jneuroim.2012.07.013
Abdallah MW, 2012, BRAIN BEHAV IMMUN, V26, P170, DOI 10.1016/j.bbi.2011.09.003
Abdallah MW, 2013, WORLD J BIOL PSYCHIA, V14, P528, DOI 10.3109/15622975.2011.639803
AL-Ayadhi LY, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-158
Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P840, DOI 10.1016/j.bbi.2010.09.002
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Bauer S, 2007, NAT REV NEUROSCI, V8, P221, DOI 10.1038/nrn2054
Blumberg SJ, 2013, NATL CTR HLTH STAT, V2013, P65
Brown AS, 2014, MOL PSYCHIATR, V19, P259, DOI 10.1038/mp.2012.197
CHESS S, 1971, J AUTISM CHILD SCHIZ, V1, P33, DOI 10.1007/BF01537741
Croen LA, 2005, PEDIATRICS, V115, pE135, DOI 10.1542/peds.2004-1870
Croen LA, 2008, AUTISM RES, V1, P130, DOI 10.1002/aur.14
Dammann O, 2008, CLIN PERINATOL, V35, P643, DOI 10.1016/j.clp.2008.07.011
de Jager W, 2009, BMC IMMUNOL, V10, DOI 10.1186/1471-2172-10-52
DEYKIN EY, 1979, AM J EPIDEMIOL, V109, P628
Dinarello CA, 2000, CHEST, V118, P503, DOI 10.1378/chest.118.2.503
Enstrom A, 2009, BRAIN BEHAV IMMUN, V23, P389, DOI 10.1016/j.bbi.2008.12.005
Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
Goines PE, 2013, NEUROTOXICOL TERATOL, V36, P67, DOI 10.1016/j.ntt.2012.07.006
Grether JK, 2010, AUTISM RES, V3, P323, DOI 10.1002/aur.160
Heuer L, 2008, AUTISM RES, V1, P275, DOI 10.1002/aur.42
Heuer LS, 2012, J NEUROIMMUNOL, V251, P94, DOI 10.1016/j.jneuroim.2012.07.001
Jyonouchi H, 2001, J NEUROIMMUNOL, V120, P170, DOI 10.1016/S0165-5728(01)00421-0
KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
Manzardo AM, 2012, INT J DEV NEUROSCI, V30, P121, DOI 10.1016/j.ijdevneu.2011.12.003
Nelson PG, 2006, INT J DEV NEUROSCI, V24, P73, DOI 10.1016/j.ijdevneu.2005.10.003
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Pardo Carlos A, 2005, Int Rev Psychiatry, V17, P485, DOI 10.1080/02646830500381930
Ponzio NM, 2007, ANN NY ACAD SCI, V1107, P118, DOI 10.1196/annals.1381.013
Rostene W, 2011, FRONT NEUROENDOCRIN, V32, P10, DOI 10.1016/j.yfrne.2010.07.001
Rostene W, 2007, NAT REV NEUROSCI, V8, P895, DOI 10.1038/nrn2255
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Suzuki K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020470
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
Zerbo O., 2013, J AUTISM DEV DISORD, DOI [10.1007/s10803-013-2016-3, DOI 10.1007/S10803-013-2016-3]
Zerbo O, 2012, J AUTISM DEV DISORD, DOI [10.1007/s10803-012-1540-x, DOI 10.1007/S10803-012-1540-X]
NR 45
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD JUN 20
PY 2014
VL 11
AR 113
DI 10.1186/1742-2094-11-113
PG 9
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA AL0AR
UT WOS:000338790200001
PM 24951035
ER
PT J
AU Lorenz, T
Heinitz, K
AF Lorenz, Timo
Heinitz, Kathrin
TI Aspergers - Different, Not Less: Occupational Strengths and Job
Interests of Individuals with Asperger's Syndrome
SO PLOS ONE
LA English
DT Article
ID SELF-EFFICACY; AUTISM; ADULTS; WORK; METAANALYSIS; EXPERIENCES;
THINKING; ABILITY; TALENT; FIT
AB Rooted in the neurodiversity approach, this study provides an overview of the strengths and interests of individuals with Asperger's Syndrome. We interviewed136 individuals with Asperger's Syndrome and 155 neurotypical individuals via an online survey with regards to (a) demography, (b) occupational strengths, (c) general self-efficacy, (d) occupational self-efficacy, and (e) the job interest profile according to Holland. The vocational and educational fields of the individuals with Asperger's in the sample are more diverse than and surpass those classical fields stated in research and biographical literature. The comparison of both groups in cross-tables showed that the indicated strengths differ in several areas (Phi(Cramer) =.02-.47), which means that a specific strength profile can be derived, and this profile goes beyond the clinical view of the diagnostic criteria. Individuals with Asperger's indicate lower self-efficacy, both general and occupational. Furthermore, a high concentration of individuals with Asperger's can be found in the areas I (Investigative) and C (Conventional) of Holland's RIASEC model.
C1 [Lorenz, Timo; Heinitz, Kathrin] Free Univ Berlin, Dept Psychol, Berlin, Germany.
RP Lorenz, T (reprint author), Free Univ Berlin, Dept Psychol, Berlin, Germany.
EM timo.lorenz@fu-berlin.de
CR Alexander C, 2013, IT CONSULTANTS AUTIS
Allison C, 2011, J AM ACAD CHILD PSY, V51, p[202, e207]
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Amt fur Statistik Berlin-Brandenburg, 2013, B 3 1 J 2012 STUD HO
[Anonymous], 2011, KLASS BER 2010
Armstrong T., 2010, NEURODIVERSITY DISCO
Asperger H, 1944, EUR ARCH PSY CLIN N, V117, P76
Attwood T., 1998, ASPERGERS SYNDROME G
Attwood Tony, 2006, COMPLETE GUIDE ASPER
Bandura A, 1997, SELF EFFICACY EXERCI
Bandura A., 1994, ENCY HUMAN BEHAV, V4, P71
Benford P., 2009, J ASSISTIVE TECHNOLO, V3, P44, DOI DOI 10.1108/17549450200900015
Bergmann C., 2005, ALLGEMEINER INTERESS
Chown N, 2011, J FURTHER HIGHER ED, P1
Clifton D. O., 2003, POSITIVE ORG SCHOLAR, P111
Grandin T, 2009, PHILOS T R SOC B, V364, P1437, DOI 10.1098/rstb.2008.0297
Grandin T, 2006, THINKING PICTURES OT
Griffin E, 2009, DYSLEXIA, V15, P23, DOI 10.1002/dys.383
Griffith GM, 2012, AUTISM, V16, P532, DOI 10.1177/1362361311405223
Happe F, 2009, PHILOS T R SOC B, V364, P1369, DOI 10.1098/rstb.2008.0332
Harter JK, 2010, OXFORD HDB POSITIVE, P121
Hendricks D, 2010, J VOCATIONAL REHABIL, V32, P125, DOI DOI 10.3233/JVR-2010-0502
Hillier A, 2007, CAREER DEV EXCEPTION, V30, P35, DOI DOI 10.1177/08857288070300010501
Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
Holland J. L., 1997, MAKING VOCATIONAL CH
Howlin P, 2013, J AM ACAD CHILD PSY, V52, P897, DOI 10.1016/j.jaac.2013.06.010
Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
Jaarsma P, 2012, HEALTH CARE ANAL, V20, P20, DOI 10.1007/s10728-011-0169-9
James I, 2010, MATH INTELL, V32, P56
Jerusalem M., 1990, PERSONLICHE RESSOURC
Kapp S. K., 2012, DEV PSYCHOL, V49, P59
Kristof-Brown AL, 2005, PERS PSYCHOL, V58, P281, DOI 10.1111/j.1744-6570.2005.00672.x
Kunda M, 2008, INT C DEVEL LEARN, P304, DOI 10.1109/DEVLRN.2008.4640847
Mesibov GB, 2010, J AUTISM DEV DISORD, V40, P570, DOI 10.1007/s10803-009-0901-6
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Muller E, 2003, J VOCATIONAL REHABIL, V18, P163
Organisation for Economic Co-operation and Development, 2007, REV FIELDS SCI TECHN
Rea L. M., 1992, DESIGNING CONDUCTING
Robison John Elder, 2008, LOOK ME EYE MY LIFE
SAKS AM, 1995, J APPL PSYCHOL, V80, P211
Schmidt FL, 1998, PSYCHOL BULL, V124, P262, DOI 10.1037//0033-2909.124.2.262
Schwarzer R., 1992, SELF EFFICACY THOUGH
Schwarzer R, 1994, DIAGNOSTICA, V40, P92
Schwarzer R., 1995, MEASURES HLTH PSYCHO, P35
Schyns B, 2012, ZUSAMMENSTELLUNG SOZ
Simone R, 2010, ASPERGERS JOB MUST H
Stajkovic AD, 1998, PSYCHOL BULL, V124, P240, DOI 10.1037//0033-2909.124.2.240
Taylor JL, 2012, AJIDD-AM J INTELLECT, V117, P67, DOI 10.1352/1944-7558-117.1.67
WOOD R, 1989, J PERS SOC PSYCHOL, V56, P407, DOI 10.1037//0022-3514.56.3.407
NR 51
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 20
PY 2014
VL 9
IS 6
AR e100358
DI 10.1371/journal.pone.0100358
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK2UZ
UT WOS:000338276300068
PM 24950060
ER
PT J
AU Taylor, LE
Swerdfeger, AL
Eslick, GD
AF Taylor, Luke E.
Swerdfeger, Amy L.
Eslick, Guy D.
TI Vaccines are not associated with autism: An evidence-based meta-analysis
of case-control and cohort studies
SO VACCINE
LA English
DT Article
DE Vaccine; Vaccination; Immunisation; Autism; Autism spectrum disorder;
Thimerosal; Mercury
ID THIMEROSAL-CONTAINING VACCINES; MUMPS-RUBELLA VACCINATION; EVENT
REPORTING SYSTEM; SPECTRUM DISORDER; DEVELOPMENTAL DISORDERS; PRISMA
STATEMENT; MEASLES; POPULATION; CHILDREN; BIAS
AB There has been enormous debate regarding the possibility of a link between childhood vaccinations and the subsequent development of autism. This has in recent times become a major public health issue with vaccine preventable diseases increasing in the community due to the fear of a 'link' between vaccinations and autism. We performed a meta-analysis to summarise available evidence from case-control and cohort studies on this topic (MEDLINE, PubMed, EMBASE, Google Scholar up to April, 2014). Eligible studies assessed the relationship between vaccine administration and the subsequent development of autism or autism spectrum disorders (ASD). Two reviewers extracted data on study characteristics, methods, and outcomes. Disagreement was resolved by consensus with another author. Five cohort studies involving 1,256,407 children, and five case-control studies involving 9,920 children were included in this analysis. The cohort data revealed no relationship between vaccination and autism (OR: 0.99; 95% CI: 0.92 to 1.06) or ASD (OR: 0.91; 95% CI: 0.68 to 1.20), nor was there a relationship between autism and MMR (OR: 0.84; 95% CI: 0.70 to 1.01), or thimerosal (OR: 1.00; 95% CI: 0.77 to 1.31), or mercury (Hg) (OR: 1.00; 95% CI: 0.93 to 1.07). Similarly the case-control data found no evidence for increased risk of developing autism or ASD following MMR, Hg, or thimerosal exposure when grouped by condition (OR: 0.90, 95% CI: 0.83 to 0.98; p = 0.02) or grouped by exposure type (OR: 0.85, 95% CI: 0.76 to 0.95; p = 0.01). Findings of this meta-analysis suggest that vaccinations are not associated with the development of autism or autism spectrum disorder. Furthermore, the components of the vaccines (thimerosal or mercury) or multiple vaccines (MMR) are not associated with the development of autism or autism spectrum disorder. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Taylor, Luke E.; Swerdfeger, Amy L.; Eslick, Guy D.] Univ Sydney, Nepean Hosp, Whiteley Martin Res Ctr, Discipline Surg, Penrith, NSW 2751, Australia.
RP Eslick, GD (reprint author), Univ Sydney, Nepean Hosp, Whiteley Martin Res Ctr, Discipline Surg, Level 3,Clin Bldg,POB 63, Penrith, NSW 2751, Australia.
EM guy.eslick@sydney.edu.au
CR Almazrou AM, 2006, CURR PEDIAT RES, V10, P5
Andrews N, 2004, PEDIATRICS, V114, P584, DOI 10.1542/peds.2003-1177-L
BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
Centers for Disease Control and Prevention, 2011, MORBIDITY MORTALITY
Demicheli V, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004407.pub3
DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
DeStefano F, 2004, PEDIATRICS, V113, P259, DOI 10.1542/peds.113.2.259
Egger M, 1997, BRIT MED J, V315, P629
Goodman MJ, 2006, PEDIATRICS, V117, P387, DOI 10.1542/peds.2004-2687
Higgins JPT, 2003, BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
Hviid A, 2003, JAMA-J AM MED ASSOC, V290, P1763, DOI 10.1001/jama.290.13.1763
Jefferson T, 2003, VACCINE, V21, P3954, DOI 10.1016/S0264-410X(03)00271-8
Kimmel SR, 2007, J FAM PRACTICE, V56, pS61
Klein KC, 2004, ANN PHARMACOTHER, V38, P1297, DOI 10.1345/aph.1D293
Liberati A, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2700
Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134
Moher D, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2535
Mrozek-Budzyn D, 2010, PEDIATR INFECT DIS J, V29, P397, DOI 10.1097/INF.0b013e3181c40a8a
Mutter J, 2005, NEUROENDOCRINOL LETT, V26, P439
NSW Government Health, MEASL NOT NSW RES
Ortqvist Å, 2010, Acta Paediatr Suppl, V99, P1
Parker SK, 2004, PEDIATRICS, V114, P793, DOI 10.1542/peds.2004-0434
Price CS, 2010, PEDIATRICS, V126, P656, DOI 10.1542/peds.2010-0309
Ratajczak HV, 2011, J IMMUNOTOXICOL, V8, P68, DOI 10.3109/1547691X.2010.545086
ROSENTHAL R, 1979, PSYCHOL BULL, V86, P638, DOI 10.1037//0033-2909.86.3.638
Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
Sengupta N, 2004, EVID BASED HEALTHC P, V8, P239, DOI 10.1016/j.ehbc.2004.08.004
Smeeth L, 2001, BMC PUBLIC HEALTH, V1, DOI 10.1186/1471-2458-1-2
Smeeth L, 2004, LANCET, V364, P963, DOI 10.1016/S0140-6736(04)17020-7
Taylor B, 2002, BRIT MED J, V324, P393, DOI 10.1136/bmj.324.7334.393
Uchiyama T, 2007, J AUTISM DEV DISORD, V37, P210, DOI 10.1007/s10803-006-0157-3
Uno Y, 2012, VACCINE, V30, P4292, DOI 10.1016/j.vaccine.2012.01.093
Varricchio F, 2004, PEDIATR INFECT DIS J, V23, P287, DOI 10.1097/00006454-200404000-00002
Verstraeten T, 2003, PEDIATRICS, V112, P1039
Wells GA, NEWCASTLE OTTAWA SCA
Wilson K, 2003, ARCH PEDIAT ADOL MED, V157, P628, DOI 10.1001/archpedi.157.7.628
NR 36
TC 11
Z9 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JUN 17
PY 2014
VL 32
IS 29
BP 3623
EP 3629
DI 10.1016/j.vaccine.2014.04.085
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA AK7OF
UT WOS:000338616900010
PM 24814559
ER
PT J
AU Lajiness-O'Neill, R
Richard, AE
Moran, JE
Olszewski, A
Pawluk, L
Jacobson, D
Mansour, A
Vogt, K
Erdodi, LA
Moore, AM
Bowyer, SM
AF Lajiness-O'Neill, Renee
Richard, Annette E.
Moran, John E.
Olszewski, Amy
Pawluk, Lesley
Jacobson, Daniel
Mansour, Alfred
Vogt, Kelly
Erdodi, Laszlo A.
Moore, Aimee M.
Bowyer, Susan M.
TI Neural synchrony examined with magnetoencephalography (MEG) during eye
gaze processing in autism spectrum disorders: preliminary findings
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Eye gaze; Neural synchrony; Coherence;
Magnetoencephalography; Social cognition
ID HIGH-FUNCTIONING AUTISM; GAMMA-BAND RESPONSES; JOINT ATTENTION;
1ST-DEGREE RELATIVES; VISUAL-ATTENTION; YOUNG-CHILDREN; CONNECTIVITY;
BRAIN; INDIVIDUALS; LANGUAGE
AB Background: Gaze processing deficits are a seminal, early, and enduring behavioral deficit in autism spectrum disorder (ASD); however, a comprehensive characterization of the neural processes mediating abnormal gaze processing in ASD has yet to be conducted.
Methods: This study investigated whole-brain patterns of neural synchrony during passive viewing of direct and averted eye gaze in ASD adolescents and young adults (M-Age = 16.6) compared to neurotypicals (NT) (M-Age = 17.5) while undergoing magnetoencephalography. Coherence between each pair of 54 brain regions within each of three frequency bands (low frequency (0 to 15 Hz), beta (15 to 30 Hz), and low gamma (30 to 45 Hz)) was calculated.
Results: Significantly higher coherence and synchronization in posterior brain regions (temporo-parietal-occipital) across all frequencies was evident in ASD, particularly within the low 0 to 15 Hz frequency range. Higher coherence in fronto-temporo-parietal regions was noted in NT. A significantly higher number of low frequency cross-hemispheric synchronous connections and a near absence of right intra-hemispheric coherence in the beta frequency band were noted in ASD. Significantly higher low frequency coherent activity in bilateral temporo-parieto-occipital cortical regions and higher gamma band coherence in right temporo-parieto-occipital brain regions during averted gaze was related to more severe symptomology as reported on the Autism Diagnostic Interview-Revised (ADI-R).
Conclusions: The preliminary results suggest a pattern of aberrant connectivity that includes higher low frequency synchronization in posterior cortical regions, lack of long-range right hemispheric beta and gamma coherence, and decreased coherence in fronto-temporo-parietal regions necessary for orienting to shifts in eye gaze in ASD; a critical behavior essential for social communication.
C1 [Lajiness-O'Neill, Renee; Richard, Annette E.; Olszewski, Amy; Pawluk, Lesley; Mansour, Alfred; Vogt, Kelly; Moore, Aimee M.] Eastern Michigan Univ, Ypsilanti, MI 48197 USA.
[Lajiness-O'Neill, Renee] Univ Michigan Hlth Syst, Neuropsychol Sect, Dept Psychiat, Ann Arbor, MI USA.
[Lajiness-O'Neill, Renee; Moran, John E.; Pawluk, Lesley; Bowyer, Susan M.] Henry Ford Hosp, Detroit, MI 48202 USA.
[Olszewski, Amy] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
[Jacobson, Daniel] USMS, US Air Force, Biloxi, MS USA.
[Erdodi, Laszlo A.] Geisel Sch Med Dartmouth, Dept Psychiat, Lebanon, NH USA.
[Bowyer, Susan M.] Wayne State Univ, Detroit, MI USA.
[Bowyer, Susan M.] Oakland Univ, Rochester, MI 48063 USA.
RP Lajiness-O'Neill, R (reprint author), Eastern Michigan Univ, Ypsilanti, MI 48197 USA.
EM rlajines@gmail.com
FU Eastern Michigan University
FX This research was supported in part by grants from a new faculty award
(NFA) and a faculty research fellowship award (FRF) from Eastern
Michigan University awarded to the first author.
CR American Psychiatric Association, 2000, DIAG STAT MAN MENT D
Andrew C, 1996, ELECTROEN CLIN NEURO, V98, P144
Bailey AJ, 2005, EUR J NEUROSCI, V21, P2575, DOI 10.1111/j.1460-9568.2005.04061.x
Baldwin DA, 1995, UNDERSTANDING LINK J, P131
BaronCohen S, 1997, CHILD DEV, V68, P48
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
Centers for Disease Control and Prevention (CDC), 2011, AUT SPECT DISORD 201
Cornew L, 2012, J AUTISM DEV DISORD, V42, P1884, DOI 10.1007/s10803-011-1431-6
Davies MS, 2011, BRAIN BEHAV, V1, P1, DOI 10.1002/brb3.6
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
Efron B., 2010, LARGE SCALE INFERENC
Elisevich K, 2011, EPILEPSIA, V52, P1110, DOI 10.1111/j.1528-1167.2011.02990.x
Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
Elsabbagh M, 2012, CURR BIOL, V22, P338, DOI 10.1016/j.cub.2011.12.056
Emery NJ, 2000, NEUROSCI BIOBEHAV R, V24, P581, DOI 10.1016/S0149-7634(00)00025-7
Ethofer T, 2011, NEUROIMAGE, V55, P411, DOI 10.1016/j.neuroimage.2010.11.033
Falter CM, 2013, J AUTISM DEV DISORD, V43, P1857, DOI 10.1007/s10803-012-1735-1
Fries P, 2001, SCIENCE, V291, P1560, DOI 10.1126/science.1055465
Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031
Goldberg MC, 2008, J AUTISM DEV DISORD, V38, P1405, DOI 10.1007/s10803-007-0506-x
Grice SJ, 2005, CORTEX, V41, P342, DOI 10.1016/S0010-9452(08)70271-5
Khan S, 2013, P NATL ACAD SCI USA, V110, P3107, DOI 10.1073/pnas.1214533110
Kopell N, 2000, P NATL ACAD SCI USA, V97, P1867, DOI 10.1073/pnas.97.4.1867
Kylliainen A, 2004, J AUTISM DEV DISORD, V29, P499
Kylliainen A, 2006, EUR J NEUROSCI, V23, P801, DOI 10.1111/j.1460-9568.2005.04554.x
Lajiness-O'Neill R, 2010, IFMBE P, P381
Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
McFadden KL, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-213
Minzenberg MJ, 2010, NEUROPSYCHOPHARMACOL, V35, P2590, DOI 10.1038/npp.2010.150
Morales M, 2000, J APPL DEV PSYCHOL, V21, P283, DOI 10.1016/S0193-3973(99)00040-4
Moran JE, 2005, BRAIN TOPOGR, V18, P1, DOI 10.1007/s10548-005-7896-x
Moran JE, 2006, INT C SER NEW FRONT, V1300, P673
Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
Ozerdem A, 2008, BRAIN RES, V1235, P98, DOI 10.1016/j.brainres.2008.06.101
Pelphrey KA, 2003, NEUROPSYCHOLOGIA, V41, P156, DOI 10.1016/S0028-3932(02)00146-X
Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404
Pitskel NB, 2011, J AUTISM DEV DISORD, V41, P1686, DOI 10.1007/s10803-011-1197-x
Pollonini L, 2010, IEEE ENG MED BIO, P1730, DOI 10.1109/IEMBS.2010.5626702
Richard AE, 2013, NEUROREPORT, V24, P894, DOI 10.1097/WNR.0000000000000015
Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
Roeyers H, 1998, DEV PSYCHOPATHOL, V10, P441, DOI 10.1017/S0954579498001680
Rojas DC, 2008, BMC PSYCHIATRY, V9, P1
Rojas DC, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-11
Schipul Sarah E, 2011, Front Syst Neurosci, V5, P10, DOI 10.3389/fnsys.2011.00010
Seghier ML, 2010, CEREB CORTEX, V20, P570, DOI 10.1093/cercor/bhp123
Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x
Shattuck DW, 2008, NEUROIMAGE, V39, P1064, DOI 10.1016/j.neuroimage.2007.09.031
Srinivasan R, 2007, J NEUROSCI METH, V166, P41, DOI 10.1016/j.jneumeth.2007.06.026
Stevenson JL, 2010, J NEUROSCI, V30, P16763, DOI 10.1523/JNEUROSCI.4946-10.2010
Swettenham J, 2003, PHILOS T R SOC B, V358, P325, DOI 10.1098/rstb.2002.1203
Talairach J, 1988, CO PLANAR STERIOTAXI
Tallon-Baudry C, 1999, TRENDS COGN SCI, V3, P151, DOI 10.1016/S1364-6613(99)01299-1
Tsiaras V, 2011, COMPUT BIOL MED, V41, P1166, DOI 10.1016/j.compbiomed.2011.04.004
Uhlhaas Peter J, 2006, Neuron, V52, P155, DOI 10.1016/j.neuron.2006.09.020
Vlamings PHJM, 2005, J AUTISM DEV DISORD, V35, P267, DOI 10.1007/s10803-005-3289-y
Wechsler D, 1999, WECHSLER ABBREVIATED
Wilson TW, 2013, NEUROPSYCHOLOGY, V27, P654, DOI 10.1037/a0034032
Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002
Woods RP, 1998, J COMPUT ASSIST TOMO, V22, P153, DOI 10.1097/00004728-199801000-00028
Wright B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041326
NR 69
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUN 17
PY 2014
VL 6
AR 15
DI 10.1186/1866-1955-6-15
PG 22
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AK5MR
UT WOS:000338469400001
PM 24976870
ER
PT J
AU Chen, YW
Lin, HC
Ng, MC
Hsiao, YH
Wang, CC
Gean, PW
Chen, PS
AF Chen, Yu-Wen
Lin, Hui-Ching
Ng, Ming-Chong
Hsiao, Ya-Hsin
Wang, Chao-Chuan
Gean, Po-Wu
Chen, Po See
TI Activation of rinGluR2/3 underlies the effects of N-acetylcystein on
amygdala-associated autism-like phenotypes in a valproate-induced rat
model of autism
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE amygdala; autistic spectrum disorders; valproate; N-acetylcysteine;
glutamate
ID METABOTROPIC GLUTAMATE RECEPTORS; SPECTRUM DISORDERS; NUCLEUS-ACCUMBENS;
SOCIAL-BEHAVIOR; PROPIONIC-ACID; CHILDREN; BRAIN; HIPPOCAMPUS; RELEASE;
PATHOGENESIS
AB Autism-like phenotypes in male valproate (VPA)-exposed offspring have been linked to high glutamatergic neurotransmission in the thalamic-amygdala pathway. Glial cystine/glutamate exchange (system Xc(-)), which exchanges extracellular cystine for intracellular glutamate, plays a significant role in the maintenance of extracellular glutamate. N-acetylcysteine (NAC) is a cystine prodrug that restores extracellular glutamate by stimulating system Xc(-). In this study, we examined the effects of NAC on autism-like phenotypes and neurotransmission in the thalamic amygdala synapses, as well as the involvement of metabotropic glutamate receptors 2/3 (mGluR2/3). Valproate-treated rats received a single intraperitoneal injection of 500 mg/kg NaVPA on E12.5. On postnatal day 21 (P21), NAC or saline was administered once daily for 10 days. From day 8 to 10, NAC was given 1/2 h prior to behavioral testing. Chronic administration of NAC restored the duration and frequency of social interaction and ameliorated anxiety-like behaviors in VPA-exposed offspring. In amygdala slices, NAC treatment normalized the increased frequency of mEPSCs and decreased the paired pulse facilitation (PPF) induced by VPA exposure. The effects of NAC on social interaction and anxiety-like behavior in the VPA-exposed offspring were blocked after intra-amygdala infusion of mGluR2/3 antagonist LY341495. The expressions of mGluR2/3 protein and mGluR2 mRNA were significantly lower in the VPA-exposed offspring. In contrast, the mGluR3 mRNA level did not differ between the saline- and VPA-exposed offspring. These results provide the first evidence that the disruption of social interaction and enhanced presynaptic excitatory transmission in VPA-exposed offspring could be rescued by NAC, which depends on the activation of mGluR2/3.
C1 [Chen, Yu-Wen; Hsiao, Ya-Hsin; Gean, Po-Wu] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70403, Taiwan.
[Lin, Hui-Ching] Natl Yang Ming Univ, Sch Med, Dept & Inst Physiol, Taipei 112, Taiwan.
[Lin, Hui-Ching] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan.
[Ng, Ming-Chong; Chen, Po See] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, Tainan 70403, Taiwan.
[Wang, Chao-Chuan] Kaohsiung Med University, Coll Med, Dept Anat, Kaohsiung, Taiwan.
[Chen, Po See] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70403, Taiwan.
RP Gean, PW (reprint author), Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, 138 Sheng Li Road, Tainan 70403, Taiwan.
EM powu@mail.ncku.edu.tw; chenps@mail.ncku.edu.tw
FU National Science Council [NSC 99-2628-B-006-013, NSC 101-2321-B-006-025,
NSC 102-2321-B-010-025, NSC 102-2320-B-010-009]; National Health
Research Institute of Taiwan [NHRI-EX102-10117NI]; Brain Research
Center, National Yang-Ming University; Ministry of Education, Aim for
the Top University Plan; Headquarters of University Advancement at the
National Cheng Kung University [D103-35A09]; Ministry of Education,
Taiwan, ROC
FX This study was supported by grants NSC 99-2628-B-006-013, NSC
101-2321-B-006-025, NSC 102-2321-B-010-025, NSC 102-2320-B-010-009 from
the National Science Council and NHRI-EX102-10117NI from the National
Health Research Institute of Taiwan. This study was also supported by
Brain Research Center, National Yang-Ming University and a grant from
Ministry of Education, Aim for the Top University Plan. This research
also received funding (D102-35001 and D103-35A09) from the Headquarters
of University Advancement at the National Cheng Kung University, which
is sponsored by the Ministry of Education, Taiwan, ROC. The funding
institutions of this study had no further role in the study design, the
collection, analysis, and interpretation of data, the writing of this
paper, or the decision to submit it for publication.
CR Adolphs R, 2001, NEUROPSYCHOLOGY, V15, P396, DOI 10.1037//0894-4105.15.3.396
Aylward EH, 1999, NEUROLOGY, V53, P2145
Baharnoori M, 2012, SCHIZOPHRENIA BULL, V38, P444, DOI 10.1093/schbul/sbq098
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baker DA, 2002, J NEUROSCI, V22, P9134
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
Baron-Cohen S, 2005, ANNU REV NEUROSCI, V28, P109, DOI 10.1146/annurev.neuro.27.070203.144137
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
Bateup HS, 2013, NEURON, V78, P510, DOI 10.1016/j.neuron.2013.03.017
Christensen J, 2013, JAMA-J AM MED ASSOC, V309, P1696, DOI 10.1001/jama.2013.2270
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Eichler Sabrina A, 2008, Front Mol Neurosci, V1, P2, DOI 10.3389/neuro.02.002.2008
El-Ansary AK, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-74
Farr SA, 2003, J NEUROCHEM, V84, P1173, DOI 10.1046/j.0022-3042.2003.01580.x
Flagstad P, 2004, NEUROPSYCHOPHARMACOL, V29, P2052, DOI 10.1038/sj.npp.1300516
Foley KA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087072
Fu AL, 2006, BRAIN RES, V1109, P201, DOI 10.1016/j.brainres.2006.06.042
Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283
Hardan AY, 2012, BIOL PSYCHIAT, V71, P956, DOI 10.1016/j.biopsych.2012.01.014
Hascup ER, 2012, J NEUROCHEM, V122, P619, DOI 10.1111/j.1471-4159.2012.07784.x
Hsia AY, 1998, J NEUROPHYSIOL, V79, P2013
Kalivas PW, 2009, NAT REV NEUROSCI, V10, P561, DOI 10.1038/nrn2515
Khan M, 2004, J NEUROSCI RES, V76, P519, DOI 10.1002/jnr.20087
Kupchik YM, 2012, BIOL PSYCHIAT, V71, P978, DOI 10.1016/j.biopsych.2011.10.024
Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
Lin HC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055248
MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
Nacewicz BM, 2006, ARCH GEN PSYCHIAT, V63, P1417, DOI 10.1001/archpsyc.63.12.1417
Ornstein PL, 1998, J MED CHEM, V41, P358, DOI 10.1021/jm970498o
Palmer RF, 2009, HEALTH PLACE, V15, P18, DOI 10.1016/j.healthplace.2008.02.001
Parachikova A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014015
Reissner KJ, 2010, BEHAV PHARMACOL, V21, P514, DOI 10.1097/FBP.0b013e32833d41b2
Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
Rojas DC, 2004, AM J PSYCHIAT, V161, P2038, DOI 10.1176/appi.ajp.161.11.2038
Santini E, 2013, NATURE, V493, P411, DOI 10.1038/nature11782
Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
Shultz SR, 2009, BEHAV BRAIN RES, V200, P33, DOI 10.1016/j.bbr.2008.12.023
Todd RM, 2009, NAT NEUROSCI, V12, P1217, DOI 10.1038/nn1009-1217
Tyzio R, 2014, SCIENCE, V343, P675, DOI 10.1126/science.1247190
Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66
Wang CC, 2013, INT J NEUROPSYCHOPH, V16, P2027, DOI 10.1017/S1461145713000473
WASHBURN MS, 1992, J NEUROSCI, V12, P4066
Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
Wood A., EVID BASED IN PRESS, DOI [10.1136/eb-2013-101422, DOI 10.1136/EB-2013-101422]
Zucker RS, 2002, ANNU REV PHYSIOL, V64, P355, DOI 10.1146/annurev.physiol.64.092501.114547
NR 48
TC 2
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD JUN 17
PY 2014
VL 8
AR 219
DI 10.3389/fnbeh.2014.00219
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AK0OY
UT WOS:000338114900001
PM 24987341
ER
PT J
AU Allegra, M
Genovesi, S
Maggia, M
Cenni, MC
Zunino, G
Sgado, P
Caleo, M
Bozzi, Y
AF Allegra, Manuela
Genovesi, Sacha
Maggia, Marika
Cenni, Maria C.
Zunino, Giulia
Sgado, Paola
Caleo, Matteo
Bozzi, Yuri
TI Altered GABAergic markers, increased binocularity and reduced plasticity
in the visual cortex of Engrailed-2 knockout mice
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Article
DE plasticity; inhibition; monocular deprivation; critical period;
neurodevelopmental disorder
ID OCULAR DOMINANCE PLASTICITY; EXPERIENCE-DEPENDENT PLASTICITY; AUTISM
SPECTRUM DISORDERS; CRITICAL-PERIOD PLASTICITY; FRAGILE-X-SYNDROME;
MUTANT MICE; INTRACORTICAL INHIBITION; ENVIRONMENTAL ENRICHMENT;
MONOCULAR DEPRIVATION; RECEPTIVE FIELDS
AB The maturation of the GABAergic system is a crucial determinant of cortical development during early postnatal life, when sensory circuits undergo a process of activity-dependent refinement. An altered excitatory/inhibitory balance has been proposed as a possible pathogenic mechanism of autism spectrum disorders (ASD). The homeobox-containing transcription factor Engrailed-2 (En2) has been associated to ASD, and En2 knockout (En(2-/-)) mice show ASD-like features accompanied by a partial loss of cortical GABAergic interneurons. Here we studied GABAergic markers and cortical function in En(2-/-) mice, by exploiting the well-known anatomical and functional features of the mouse visual system. En2 is expressed in the visual cortex at postnatal day 30 and during adulthood. When compared to age-matched En(2+/+) controls, En(2-/-) mice showed an increased number of parvalbumin (PV+), somatostatin (SOM+), and neuropeptide Y (NPY+) positive interneurons in the visual cortex at P30, and a decreased number of SOM+ and NPY+ interneurons in the adult. At both ages, the differences in distinct interneuron populations observed between En(2+/+)and En(2-/-) mice were layer-specific. Adult En(2-/-) mice displayed a normal eye-specific segregation in the retino-geniculate pathway, and in vivo electrophysiological recordings showed a normal development of basic functional properties (acuity, response latency, receptive field size) of the En(2-/-) primary visual cortex. However, a significant increase of binocularity was found in P30 and adult En(2-/-) mice, as compared to age-matched controls. Differently from what observed in En(2+/+) mice, the En(2-/-) primary visual cortex did not respond to a brief monocular deprivation performed between P26 and P29, during the so-called "critical period." These data suggest that altered GABAergic circuits impact baseline binocularity and plasticity in En(2-/-) mice, while leaving other visual functional properties unaffected.
C1 [Allegra, Manuela; Cenni, Maria C.; Caleo, Matteo; Bozzi, Yuri] CNR, Inst Neurosci, I-56100 Pisa, Italy.
[Allegra, Manuela] Scuola Normale Super Pisa, Neurobiol Lab, Pisa, Italy.
[Genovesi, Sacha; Maggia, Marika; Zunino, Giulia; Sgado, Paola; Bozzi, Yuri] Univ Trento, Ctr Integrat Biol, Lab Mol Neuropathol, I-38123 Mattarello, Trento, Italy.
RP Bozzi, Y (reprint author), Univ Trento, Ctr Integrat Biol, Lab Mol Neuropathol, Via Regole 101, I-38123 Mattarello, Trento, Italy.
EM bozzi@science.unitn.it
FU Italian Ministry of University and Research [200894SYW2_002,
2010N8PBAA_002]; University of Trento; Telethon [GGP11116]; PRIN
[2012MKKTNW_002]; Provincia Autonoma di Trento (Italy) under the Marie
Curie-People cofunding action of the European Community
FX We are grateful to the technical/administrative staff of the Centre for
Integrative Biology (University of Trento) and CNR Neuroscience
Institute for excellent assistance. This work was funded by grants from
the Italian Ministry of University and Research (PRIN 2008 grant
200894SYW2_002 and PRIN 2010-11 grant 2010N8PBAA_002) and the University
of Trento (CIBIO start-up) to Yuri Bozzi, and Telethon project GGP11116
and PRIN grant 2012MKKTNW_002 to Matteo Ca leo. Paola Sgada is supported
by Provincia Autonoma di Trento (Italy) under the Marie Curie-People
cofunding action of the European Community.
CR Ascoli GA, 2008, NAT REV NEUROSCI, V9, P557, DOI 10.1038/nrn2402
Baroncelli L, 2010, EXP NEUROL, V226, P100, DOI 10.1016/j.expneurol.2010.08.009
Benayed R, 2009, BIOL PSYCHIAT, V66, P911, DOI 10.1016/j.biopsych.2009.05.027
Brielmaier J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040914
Brunet I, 2005, NATURE, V438, P94, DOI 10.1038/nature04110
CELIO MR, 1990, NEUROSCIENCE, V35, P375, DOI 10.1016/0306-4522(90)90091-H
Centonze D, 2008, BIOL PSYCHIAT, V63, P963, DOI 10.1016/j.biopsych.2007.09.008
Cerri C, 2010, EUR J NEUROSCI, V32, P1163, DOI 10.1111/j.1460-9568.2010.07363.x
Cerri C, 2011, J NEUROSCI, V31, P15163, DOI 10.1523/JNEUROSCI.2617-11.2011
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Cheh MA, 2006, BRAIN RES, V1116, P166, DOI 10.1016/j.brainres.2006.07.086
Curia G, 2009, CEREB CORTEX, V19, P1515, DOI 10.1093/cercor/bhn159
Di Cristo G, 2004, NAT NEUROSCI, V7, P1184, DOI 10.1038/nn1334
Doelen G., 2007, NEURON, V56, P955, DOI [10.1016/j.neuron.2007.12.001, DOI 10.1016/J.NEURON.2007.12.001]
Eto R, 2010, INT J DEV NEUROSCI, V28, P359, DOI 10.1016/j.ijdevneu.2010.04.004
FAGIOLINI M, 1994, VISION RES, V34, P709, DOI 10.1016/0042-6989(94)90210-0
Fagiolini M, 2000, NATURE, V404, P183
Fagiolini M, 2003, P NATL ACAD SCI USA, V100, P2854, DOI 10.1073/pnas.0536089100
Fuchs J, 2012, EUR J NEUROSCI, V35, P1837, DOI 10.1111/j.1460-9568.2012.08139.x
Gianfranceschi L, 2003, P NATL ACAD SCI USA, V100, P12486, DOI 10.1073/pnas.1934836100
Gilby KL, 2013, EPILEPSY BEHAV, V26, P370, DOI 10.1016/j.yebeh.2012.11.002
Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
Gonchar Yuri, 2007, Front Neuroanat, V1, P3, DOI 10.3389/neuro.05.003.2007
Gordon JA, 1996, J NEUROSCI, V16, P3274
Greifzu F, 2014, P NATL ACAD SCI USA, V111, P1150, DOI 10.1073/pnas.1313385111
Harauzov A, 2010, J NEUROSCI, V30, P361, DOI 10.1523/JNEUROSCI.2233-09.2010
Hensch TK, 1998, SCIENCE, V282, P1504, DOI 10.1126/science.282.5393.1504
Hensch TK, 2005, NAT REV NEUROSCI, V6, P877, DOI 10.1038/nrn1787
Hofer SB, 2006, NAT NEUROSCI, V9, P127, DOI 10.1038/nn1610
Huang ZJ, 1999, CELL, V98, P739, DOI 10.1016/S0092-8674(00)81509-3
HUBEL DH, 1963, J NEUROPHYSIOL, V26, P994
HUBEL DH, 1962, J PHYSIOL-LONDON, V160, P106
Jinno S, 2010, HIPPOCAMPUS, V20, P829, DOI 10.1002/hipo.20685
JOYNER AL, 1991, SCIENCE, V251, P1239, DOI 10.1126/science.1672471
Kuemerle B, 1997, J NEUROSCI, V17, P7881
Lazarus MS, 2011, J NEUROPHYSIOL, V106, P775, DOI 10.1152/jn.00729.2010
Lehmann K, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003120
Levelt CN, 2012, ANNU REV NEUROSCI, V35, P309, DOI 10.1146/annurev-neuro-061010-113813
Ma WP, 2010, J NEUROSCI, V30, P14371, DOI 10.1523/JNEUROSCI.3248-10.2010
Markram H, 2004, NAT REV NEUROSCI, V5, P793, DOI 10.1038/nrn1519
Matyas F, 2004, HIPPOCAMPUS, V14, P460, DOI 10.1002/hipo.10191
McCurry CL, 2010, NAT NEUROSCI, V13, P450, DOI 10.1038/nn.2508
McGee AW, 2005, SCIENCE, V309, P2222, DOI 10.1126/science.1114362
Menna E, 2003, MOL CELL NEUROSCI, V24, P972, DOI 10.1016/S1044-7431(03)00258-6
Pfeffer CK, 2013, NAT NEUROSCI, V16, P1068, DOI 10.1038/nn.3446
Pham TA, 2004, LEARN MEMORY, V11, P738, DOI 10.1101/lm.75304
Pietrasanta M, 2012, NEURAL PLAST, V2012, DOI [10.1155/2012/838672, DOI 10.1155/2012/838672]
Pinto L, 2009, NAT NEUROSCI, V12, P1229, DOI 10.1038/nn.2399
Pizzorusso T, 2002, SCIENCE, V298, P1248, DOI 10.1126/science.1072699
Provenzano G, 2012, DIS MARKERS, V33, P225, DOI 10.3233/DMA-2012-0917
Restani L, 2009, NEURON, V64, P707, DOI 10.1016/j.neuron.2009.10.019
Rittenhouse CD, 1999, NATURE, V397, P347
Rossi FM, 2001, P NATL ACAD SCI USA, V98, P6453, DOI 10.1073/pnas.101120998
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Rudy B, 2011, DEV NEUROBIOL, V71, P45, DOI 10.1002/dneu.20853
Sale A, 2007, NAT NEUROSCI, V10, P679, DOI 10.1038/nn1899
Sato M, 2008, J NEUROSCI, V28, P10278, DOI 10.1523/JNEUROSCI.2451-08.2008
Sawtell NB, 2003, NEURON, V38, P977, DOI 10.1016/S0896-6273(03)00323-4
Sgado P, 2013, EXP NEUROL, V247, P496, DOI 10.1016/j.expneurol.2013.01.021
Sgado P, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-51
Stellwagen D, 2002, NEURON, V33, P357, DOI 10.1016/S0896-6273(02)00577-9
Sugiyama S, 2008, CELL, V134, P508, DOI 10.1016/j.cell.2008.05.054
Tanahira C, 2009, NEUROSCI RES, V63, P213, DOI 10.1016/j.neures.2008.12.007
Tripathi PP, 2009, NEUROSCIENCE, V159, P842, DOI 10.1016/j.neuroscience.2009.01.007
Tropea D, 2009, PHILOS T R SOC B, V364, P341, DOI 10.1098/rstb.2008.0269
Tropea D, 2009, P NATL ACAD SCI USA, V106, P2029, DOI 10.1073/pnas.0812394106
Wilson NR, 2012, NATURE, V488, P343, DOI 10.1038/nature11347
Wizenmann A, 2009, NEURON, V64, P355, DOI 10.1016/j.neuron.2009.09.018
Yashiro K, 2009, NAT NEUROSCI, V12, P777, DOI 10.1038/nn.2327
Ye Q, 2013, MATRIX BIOL, V32, P352, DOI 10.1016/j.matbio.2013.04.001
Zhao XY, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3088
NR 71
TC 4
Z9 4
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD JUN 17
PY 2014
VL 8
AR 163
DI 10.3389/fncel.2014.00163
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA AJ5MF
UT WOS:000337726600001
PM 24987331
ER
PT J
AU Mouti, A
Reddihough, D
Marraffa, C
Hazell, P
Wray, J
Lee, K
Kohn, M
AF Mouti, Anissa
Reddihough, Dinah
Marraffa, Catherine
Hazell, Philip
Wray, John
Lee, Katherine
Kohn, Michael
TI Fluoxetine for Autistic Behaviors (FAB trial): study protocol for a
randomized controlled trial in children and adolescents with autism
SO TRIALS
LA English
DT Article
DE Autism Spectrum Disorder (ASD); Autism; Serotonin Reuptake Inhibitors
(SSRIs); Fluoxetine; Repetitive and Restricted Behaviors; Randomized
Controlled Trial (RCT); Drug Therapy; Children; Adolescents; Safety and
Efficacy
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; PSYCHOMETRIC
PROPERTIES; PSYCHOACTIVE MEDICINES; REPETITIVE BEHAVIORS; INDIVIDUALS;
SCALE; PREVALENCE; CHILDHOOD; ANXIETY
AB Background: Serotonin reuptake inhibitors (SSRIs) are commonly prescribed off-label for children with autism. To date, clinical trials examining the use of SSRIs in autism have been limited by small sample sizes and inconclusive results. The efficacy and safety of SSRIs for moderating autistic behaviors is yet to be adequately examined to provide evidence to support current clinical practice. The aim of the Fluoxetine for Autistic Behaviors (FAB) study is to determine the efficacy and safety of low dose fluoxetine compared with placebo, for reducing the frequency and severity of repetitive stereotypic behaviors in children and adolescents with an autism spectrum disorder (ASD). The relationship between the effectiveness of fluoxetine treatment and serotonin transporter genotype will also be explored.
Methods/Design: The FAB study is a multicenter, double-blinded, randomized controlled trial, funded by the Australian Government's National Health and Medical Research Council (NHMRC) grant. Participants will be aged between 7.5 and 17 years with a confirmed diagnosis of ASD. Eligible participants will be randomized to either placebo or fluoxetine for a 16-week period. Medication will be titrated over the first four weeks. Reponses to medication will be monitored fortnightly using the Clinical Global Impressions Scale (CGI). The primary outcome measure is the Children's Yale-Brown Obsessive Compulsive Scale-Modified for Pervasive Developmental Disorders (CYBOCS-PDD), administered at baseline and 16 weeks. Secondary outcome measures include the Aberrant Behaviour Scale (ABC), the Spence Children's Anxiety Scale Parent Report (SCAS-P), and the Repetitive Behaviors Scale (RBS-R), measured at baseline and 16 weeks. Participants will be invited to undergo genetic testing for SLC6A4 allele variants using a cheek swab. Continuous outcomes, including the primary outcome will be compared between the active and placebo groups using unadjusted linear regression. Binary outcomes will be compared using unadjusted logistic regression.
Discussion: The FAB study is a large clinical trial to specifically investigate the efficacy of low dose fluoxetine for restricted, repetitive, and stereotyped behaviors in ASD. The outcomes of this study will contribute to evidence-based interventions used in clinical practice to assist children with ASD.
C1 [Mouti, Anissa; Kohn, Michael] Univ Sydney, Ctr Res Adolescents Hlth CRASH, Sydney Childrens Hosp Network, Westmead Sydney Med Sch, Sydney, NSW 2145, Australia.
[Hazell, Philip] Univ Sydney, Sydney Med Sch, Discipline Psychiat, Sydney, NSW 2138, Australia.
[Reddihough, Dinah; Lee, Katherine] Univ Melbourne, Dept Pediat, Parkville, Vic 3052, Australia.
[Reddihough, Dinah; Marraffa, Catherine; Lee, Katherine] Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
[Wray, John] State Child Dev Ctr, Perth 6872, Australia.
RP Mouti, A (reprint author), Univ Sydney, Ctr Res Adolescents Hlth CRASH, Sydney Childrens Hosp Network, Westmead Sydney Med Sch, Hawkesbury Rd, Sydney, NSW 2145, Australia.
EM anissa.mouti@health.nsw.gov.au
FU National Health and Medical Research Council [NHMRC 607332]; Australian
Government
FX The study is funded by a National Health and Medical Research Council
(NHMRC 607332) grant by the Australian Government. All study-related
expenses including publication costs for manuscripts are to be covered
by this grant. We would like to acknowledge the following staff for
their work on this study: Steve Kloprogge, Molly O'Sullivan and Joanna
Granich; Francesca Orsini, Paul Lockhart, David Dossetor and his team
from Psychological Medicine, Sydney Children's Hospital Network,
Westmead, Andrew Whitehouse, Paramala Santosh, Paul Lockhart, Simon
Clarke, Alison Poulton, Jane Ho, Sue Reid, John Carlin, Natalie Silove
and Roshan Virasinghe.
CR Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
Brinkley J, 2007, J AUTISM DEV DISORD, V37, P1949, DOI 10.1007/s10803-006-0327-3
Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
COOK EH, 1992, J AM ACAD CHILD PSY, V31, P739, DOI 10.1097/00004583-199207000-00024
Guy W., 1976, ECDEU ASSESSMENT MAN
Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
Langworthy-Lam KS, 2002, J CHILD ADOL PSYCHOP, V12, P311, DOI 10.1089/104454602762599853
McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001
McDougle CJ, 2000, J AUTISM DEV DISORD, V30, P427, DOI 10.1023/A:1005551523657
McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P993
Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303
Rutter M., 2003, ADI R AUTISM DIAGNOS
Scahill L, 1997, J AM ACAD CHILD PSY, V36, P844, DOI 10.1097/00004583-199706000-00023
Scahill L, 2006, J AM ACAD CHILD PSY, V45, P1114, DOI 10.1097/01.chi.0000220854.79144.e7
Soorya L, 2008, CHILD ADOL PSYCH CL, V17, P753, DOI 10.1016/j.chc.2008.06.003
Spence SH, 2003, J ANXIETY DISORD, V17, P605, DOI 10.1016/S0887-6185(02)00236-0
Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
Sugie Y, 2005, J AUTISM DEV DISORD, V35, P377, DOI 10.1007/s10803-005-3305-2
Wechsler D., 2003, WECHSLER INTELLIGENC
Wechsler D., 2006, WECHSLER NONVERBAL S
Wechsler D., 2008, WECHSLER ADULT INTEL
Williams K, 2008, J PAEDIATR CHILD H, V44, P504, DOI 10.1111/j.1440-1754.2008.01331.x
Williams K, 2013, COCHRANE DB SYST REV
NR 29
TC 0
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JUN 16
PY 2014
VL 15
AR 230
DI 10.1186/1745-6215-15-230
PG 8
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AK5JO
UT WOS:000338461000002
PM 24934401
ER
PT J
AU Cicek, AE
Roeder, K
Ozsoyoglu, G
AF Cicek, A. Ercument
Roeder, Kathryn
Ozsoyoglu, Gultekin
TI MIRA: mutual information-based reporter algorithm for metabolic networks
SO BIOINFORMATICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; ESCHERICHIA-COLI; TRANSCRIPTIONAL REGULATION;
EXPRESSION PROFILES; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE;
ASPERGILLUS-NIDULANS; INTEGRATED ANALYSIS; SYSTEMS BIOLOGY; MICROARRAY
DATA
AB Motivation: Discovering the transcriptional regulatory architecture of the metabolism has been an important topic to understand the implications of transcriptional fluctuations on metabolism. The reporter algorithm (RA) was proposed to determine the hot spots in metabolic networks, around which transcriptional regulation is focused owing to a disease or a genetic perturbation. Using a z-score-based scoring scheme, RA calculates the average statistical change in the expression levels of genes that are neighbors to a target metabolite in the metabolic network. The RA approach has been used in numerous studies to analyze cellular responses to the downstream genetic changes. In this article, we propose a mutual information-based multivariate reporter algorithm (MIRA) with the goal of eliminating the following problems in detecting reporter metabolites: (i) conventional statistical methods suffer from small sample sizes, (ii) as z-score ranges from minus to plus infinity, calculating average scores can lead to canceling out opposite effects and (iii) analyzing genes one by one, then aggregating results can lead to information loss. MIRA is a multivariate and combinatorial algorithm that calculates the aggregate transcriptional response around a metabolite using mutual information. We show that MIRA's results are biologically sound, empirically significant and more reliable than RA.
Results: We apply MIRA to gene expression analysis of six knockout strains of Escherichia coli and show that MIRA captures the underlying metabolic dynamics of the switch from aerobic to anaerobic respiration. We also apply MIRA to an Autism Spectrum Disorder gene expression dataset. Results indicate that MIRA reports metabolites that highly overlap with recently found metabolic biomarkers in the autism literature. Overall, MIRA is a promising algorithm for detecting metabolic drug targets and understanding the relation between gene expression and metabolic activity.
C1 [Cicek, A. Ercument; Roeder, Kathryn] Carnegie Mellon Univ, Sch Comp Sci, Lane Ctr Computat Biol, Pittsburgh, PA 15213 USA.
[Ozsoyoglu, Gultekin] Case Western Reserve Univ, Sch Engn, Dept Elect Engn & Comp Sci, Cleveland, OH 44106 USA.
RP Cicek, AE (reprint author), Carnegie Mellon Univ, Sch Comp Sci, Lane Ctr Computat Biol, Pittsburgh, PA 15213 USA.
EM cicek@cs.cmu.edu
FU National Science Foundation [DBI 0743705, DBI 0849956, CRI 0551603];
National Institute of Health [GM088823]
FX This research has been supported by the National Science Foundation
grants DBI 0743705, DBI 0849956, CRI 0551603 and by the National
Institute of Health grant GM088823. A. Ercument Cicek has also been
supported by Ray and Stephanie Lane Fellowship.
CR Agren R, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002518
Albert R, 2005, J CELL SCI, V118, P4947, DOI 10.1242/jcs.02714
Aziz A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014547
Boccuto L, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-16
Brosche M, 2005, GENOME BIOL, V6, DOI 10.1186/gb-2005-6-12-r101
Butte A. J., 2000, PAC S BIOCOMPUT, V5, P418
Cakir T, 2006, MOL SYST BIOL, V2, DOI 10.1038/msb4100085
Cakmak A, 2012, J BIOINF COMPUT BIOL, V10, DOI 10.1142/S0219720012400033
Carrari F, 2006, PLANT PHYSIOL, V142, P1380, DOI 10.1104/pp.106.088534
Caspi R, 2014, NUCLEIC ACIDS RES, V42, pD459, DOI 10.1093/nar/gkt1103
Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
Chowdhury S. A., 2010, J COMPUT BIOL, V18, P263
Chuang HY, 2007, MOL SYST BIOL, V3, DOI 10.1038/msb4100180
Cicek AE, 2013, PLOS COMPUT BIOL, V9, DOI 10.1371/journal.pcbi.1002859
Cicek AE, 2012, J BIOINF COMPUT BIOL, V10, DOI 10.1142/S0219720012400045
Cimini D, 2009, BMC SYST BIOL, V3, DOI 10.1186/1752-0509-3-17
Covert MW, 2004, NATURE, V429, P92, DOI 10.1038/nature02456
Covert MW, 2003, J THEOR BIOL, V221, P309, DOI 10.1006/jtbi.2003.3071
Covert MW, 2002, J BIOL CHEM, V277, P28058, DOI 10.1074/jbc.M201691200
DARUWALA R, 1991, FEMS MICROBIOL LETT, V83, P255
Daub CO, 2004, BMC BIOINFORMATICS, V5, DOI 10.1186/1471-2105-5-118
David H, 2008, BMC GENOMICS, V9, DOI 10.1186/1471-2164-9-163
David H, 2006, GENOME BIOL, V7, DOI 10.1186/gb-2006-7-11-r108
Deo RC, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1000692
Dinu I, 2007, BMC BIOINFORMATICS, V8, DOI 10.1186/1471-2105-8-242
Draghici S, 2007, GENOME RES, V17, P1537, DOI 10.1101/gr.6202607
Duarte NC, 2007, P NATL ACAD SCI USA, V104, P1777, DOI 10.1073/pnas.0610772104
El-Ansary AK, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-62
Emond P, 2013, ANAL BIOANAL CHEM, V405, P5291, DOI 10.1007/s00216-013-6934-x
Faith JJ, 2007, PLOS BIOL, V5, P54, DOI 10.1371/journal.pbio.0050008
Feist AM, 2007, MOL SYST BIOL, V3, DOI 10.1038/msb4100155
Ferrara CT, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000034
Frye RE, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2012.143
Gerstein M, 2000, CURR OPIN STRUC BIOL, V10, P574, DOI 10.1016/S0959-440X(00)00134-2
Goh KI, 2007, P NATL ACAD SCI USA, V104, P8685, DOI 10.1073/pnas.0701361104
Gupta N, 2010, PATTERN RECOGN, V43, P2692, DOI 10.1016/j.patcog.2010.03.002
Hancock T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031345
Holm AK, 2010, J BIOL CHEM, V285, P17498, DOI 10.1074/jbc.M109.095570
Hughes TR, 2000, CELL, V102, P109, DOI 10.1016/S0092-8674(00)00015-5
Ideker T., 2002, BIOINFORMATICS, V18, pS233
Ideker T, 2001, SCIENCE, V292, P929, DOI 10.1126/science.292.5518.929
Ihmels J, 2004, NAT BIOTECHNOL, V22, P86, DOI 10.1038/nbt918
Jans A, 2011, OBESITY, V19, P2158, DOI 10.1038/oby.2011.149
KAJIE S, 1991, FEMS MICROBIOL LETT, V83, P205
Karp Peter D, 2002, Bioinformatics, V18 Suppl 1, pS225
Keseler I. M., 2013, NUCLEIC ACIDS RES, V41, P605
Kharchenko P, 2005, MOL SYST BIOL, V1, DOI 10.1038/msb4100023
Ma'ayan A, 2008, IET SYST BIOL, V2, P206, DOI 10.1049/iet-syb:20070075
MOON YI, 1995, PHYS REV E, V52, P2318, DOI 10.1103/PhysRevE.52.2318
Nam H, 2009, BIOTECHNOL BIOENG, V103, P835, DOI 10.1002/bit.22320
Oliveira AP, 2008, BMC SYST BIOL, V2, DOI 10.1186/1752-0509-2-17
Patil KR, 2005, P NATL ACAD SCI USA, V102, P2685, DOI 10.1073/pnas.0406811102
Pavlidis P., 2002, PAC S BIOCOMPUT, P474
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
PRINS RA, 1980, APPL ENVIRON MICROB, V40, P163
Rhodes DR, 2005, NAT GENET, V37, pS31, DOI 10.1038/ng1570
Richardson AJ, 2000, PROSTAG LEUKOTR ESS, V63, P1, DOI 10.1054/plef.2000.0184
Schramm G, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-39
Seshasayee ASN, 2009, GENOME RES, V19, P79, DOI 10.1101/gr.079715.108
Shlomi T, 2008, NAT BIOTECHNOL, V26, P1003, DOI 10.1038/nbt.1487
Silverman B., 1986, DENSITY ESTIMATION S
Stein T.P., 2011, J AUTISM DEV DISORD, V43, P2677
Steuer R., 2002, BIOINFORMATICS S2, V18, P231
Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
Tamiji J, 2010, NEUROSIGNALS, V18, P98, DOI 10.1159/000323189
Tanay A, 2004, P NATL ACAD SCI USA, V101, P2981, DOI 10.1073/pnas.0308661100
Tavares P, 2006, J INORG BIOCHEM, V100, P2087, DOI 10.1016/j.jinorgbio.2006.09.003
Apweiler R, 2014, NUCLEIC ACIDS RES, V42, pD191, DOI 10.1093/nar/gkt1140
Ulitsky I, 2009, BIOINFORMATICS, V25, P1158, DOI 10.1093/bioinformatics/btp118
Unden G, 1997, BBA-BIOENERGETICS, V1320, P217, DOI 10.1016/S0005-2728(97)00034-0
Usaite R, 2009, MOL SYST BIOL, V5, DOI 10.1038/msb.2009.67
van der Zwaag B, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005324
Venelli A, 2010, LECT NOTES COMPUT SC, V6033, P17, DOI 10.1007/978-3-642-12368-9_2
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Vongsangnak W, 2009, MICROBIOL-SGM, V155, P3893, DOI 10.1099/mic.0.031104-0
Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e
Yeang CH, 2006, BMC BIOINFORMATICS, V7, DOI 10.1186/1471-2105-7-332
Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
Zelezniak A, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1000729
Zhang HP, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/642524
NR 80
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1367-4803
EI 1460-2059
J9 BIOINFORMATICS
JI Bioinformatics
PD JUN 15
PY 2014
VL 30
IS 12
BP 175
EP 184
DI 10.1093/bioinformatics/btu290
PG 10
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Computer Science, Interdisciplinary Applications; Mathematical &
Computational Biology; Statistics & Probability
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Computer Science; Mathematical & Computational Biology; Mathematics
GA AK0NF
UT WOS:000338109200021
ER
PT J
AU Tilot, AK
Gaugler, MK
Yu, Q
Romigh, T
Yu, WF
Miller, RH
Frazier, TW
Eng, C
AF Tilot, Amanda K.
Gaugler, Mary K.
Yu, Qi
Romigh, Todd
Yu, Wanfeng
Miller, Robert H.
Frazier, Thomas W., II
Eng, Charis
TI Germline disruption of Pten localization causes enhanced sex-dependent
social motivation and increased glial production
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; LHERMITTE-DUCLOS-DISEASE; ATP-BINDING MOTIFS;
IN-VIVO; SUBCELLULAR-LOCALIZATION; CHROMOSOME-10 PTEN; TUMOR-SUPPRESSOR;
NUCLEAR IMPORT; MUTATIONS; BRAIN
AB PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset of autism spectrum disorder (ASD) with macrocephaly. Caused by germline mutations in PTEN, PHTS also causes increased risks of multiple cancers via dysregulation of the PI3K and MAPK signaling pathways. Conditional knockout models have shown that neural Pten regulates social behavior, proliferation and cell size. Although much is known about how the intracellular localization of PTEN regulates signaling in cancer cell lines, we know little of how PTEN localization influences normal brain physiology and behavior. To address this, we generated a germline knock-in mouse model of cytoplasm-predominant Pten and characterized its behavioral and cellular phenotypes. The homozygous Pten(m3m4) mice have decreased total Pten levels including a specific drop in nuclear Pten and exhibit region-specific increases in brain weight. The Pten(m3m4) model displays sex-specific increases in social motivation, poor balance and normal recognition memory-a profile reminiscent of some individuals with high functioning ASD. The cytoplasm-predominant protein caused cellular hypertrophy limited to the soma and led to increased NG2 cell proliferation and accumulation of glia. The animals also exhibit significant astrogliosis and microglial activation, indicating a neuroinflammatory phenotype. At the signaling level, Pten(m3m4) mice show brain region-specific differences in Akt activation. These results demonstrate that differing alterations to the same autism-linked gene can cause distinct behavioral profiles. The Pten(m3m4) model is the first murine model of inappropriately elevated social motivation in the context of normal cognition and may expand the range of autism-related behaviors replicated in animal models.
C1 [Tilot, Amanda K.; Frazier, Thomas W., II; Eng, Charis] Cleveland Clin, Dept Mol Med, Howard Hughes Med Inst, Mol Med Program,Lerner Coll Med, Cleveland, OH 44195 USA.
[Tilot, Amanda K.; Gaugler, Mary K.; Yu, Qi; Romigh, Todd; Yu, Wanfeng; Frazier, Thomas W., II; Eng, Charis] Cleveland Clin, Genom Med Inst, Cleveland, OH 44195 USA.
[Tilot, Amanda K.; Gaugler, Mary K.; Yu, Qi; Romigh, Todd; Yu, Wanfeng; Eng, Charis] Cleveland Clin, Lerner Res Inst, Cleveland, OH 44195 USA.
[Frazier, Thomas W., II] Cleveland Clin, Ctr Autism, Inst Pediat, Cleveland, OH 44195 USA.
[Eng, Charis] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44195 USA.
[Eng, Charis] Cleveland Clin, Stanley Shalom Zielony Inst Nursing Excellence, Cleveland, OH 44195 USA.
[Miller, Robert H.] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA.
[Eng, Charis] Case Western Reserve Univ, Sch Med, Dept Genet & Genome Sci, Cleveland, OH 44106 USA.
[Eng, Charis] Case Western Reserve Univ, Sch Med, CASE Comprehens Canc Ctr, Cleveland, OH 44106 USA.
RP Eng, C (reprint author), Cleveland Clin, Genom Med Inst, 9500 Euclid Ave NE 50, Cleveland, OH 44195 USA.
EM engc@ccf.org
FU National Institutes of Health [R01CA118989]
FX This work was supported, in part, by the National Institutes of Health
(R01CA118989 to C. E.), and a generous gift from Sam H. Miller.
CR Amiri A, 2012, J NEUROSCI, V32, P5880, DOI 10.1523/JNEUROSCI.5462-11.2012
Antunes M, 2012, COGN PROCESS, V13, P93, DOI 10.1007/s10339-011-0430-z
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Bevins RA, 2006, NAT PROTOC, V1, P1306, DOI 10.1038/nprot.2006.205
Bonaguidi MA, 2011, CELL, V145, P1142, DOI 10.1016/j.cell.2011.05.024
Bonde E, 2000, EUR CHILD ADOLES PSY, V9, P7
Busch RM, 2013, GENET MED, V15, P548, DOI 10.1038/gim.2013.1
Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493
Carpenter LA, 2009, PEDIATR ANN, V38, P30
Carter MT, 2013, CLIN GENET, V83, P399, DOI 10.1111/cge.12101
Chung JH, 2005, CANCER RES, V65, P4108, DOI 10.1158/0008-5472.CAN-05-0124
Chung JH, 2005, CANCER RES, V65, P8096, DOI 10.1158/0008-5472.CAN-05-1888
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Eagle RF, 2010, RES AUTISM SPECT DIS, V4, P772, DOI 10.1016/j.rasd.2010.02.001
Flores AI, 2008, J NEUROSCI, V28, P7174, DOI 10.1523/JNEUROSCI.0150-08.2008
Fombonne E, 1999, J AUTISM DEV DISORD, V29, P113, DOI 10.1023/A:1023036509476
FRANKLIN R, 1995, J INFORM ETHICS, V4, P4
Fraser MM, 2004, CANCER RES, V64, P7773, DOI 10.1158/0008-5472.CAN-04-2487
Ghaziuddin M, 2008, J AUTISM DEV DISORD, V38, P138, DOI 10.1007/s10803-007-0371-7
Guardiola-Diaz HM, 2012, GLIA, V60, P476, DOI 10.1002/glia.22281
Harrington EP, 2010, ANN NEUROL, V68, P703, DOI 10.1002/ana.22090
He X, 2011, HUM MOL GENET, V20, P80, DOI 10.1093/hmg/ddq434
Hobert JA, 2014, EUR J HUM GENET, V22, P273, DOI 10.1038/ejhg.2013.114
Jaworski J, 2005, J NEUROSCI, V25, P11300, DOI 10.1523/JNEUROSCI.2270-05.2005
Kazdoba TM, 2012, DEV NEUROSCI-BASEL, V34, P198, DOI 10.1159/000337229
Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
Kwon CH, 2001, NAT GENET, V29, P404, DOI 10.1038/ng781
Lariviere WR, 2002, PAIN, V97, P75, DOI 10.1016/S0304-3959(01)00492-4
Lobo GP, 2009, HUM MOL GENET, V18, P2851, DOI 10.1093/hmg/ddp220
Lobo GP, 2008, HUM MOL GENET, V17, P2877, DOI 10.1093/hmg/ddn185
Luikart BW, 2011, J NEUROSCI, V31, P4345, DOI 10.1523/JNEUROSCI.0061-11.2011
Maehama T, 1998, J BIOL CHEM, V273, P13375, DOI 10.1074/jbc.273.22.13375
Marino S, 2002, DEVELOPMENT, V129, P3513
McBride KL, 2010, AUTISM RES, V3, P137, DOI 10.1002/aur.132
Mehta MV, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026077
Mester JL, 2011, EUR J HUM GENET, V19, P763, DOI 10.1038/ejhg.2011.20
Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
Orrico A, 2009, CLIN GENET, V75, P195, DOI 10.1111/j.1399-0004.2008.01074.x
Page DT, 2009, P NATL ACAD SCI USA, V106, P1989, DOI 10.1073/pnas.0804428106
Redfern RE, 2010, PROTEIN SCI, V19, P1948, DOI 10.1002/pro.483
Rodriguez-Escudero I, 2011, HUM MOL GENET, V20, P4132, DOI 10.1093/hmg/ddr337
Sofroniew MV, 2010, ACTA NEUROPATHOL, V119, P7, DOI 10.1007/s00401-009-0619-8
Sperow M., 2011, J PHYSL, V590, P777
Tan MH, 2011, AM J HUM GENET, V88, P42, DOI 10.1016/j.ajhg.2010.11.013
Travers BG, 2013, J AUTISM DEV DISORD, V43, P1568, DOI 10.1007/s10803-012-1702-x
Trotman LC, 2007, CELL, V128, P141, DOI 10.1016/j.cell.2006.11.040
Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Windrem MS, 2004, NAT MED, V10, P93, DOI 10.1038/nm974
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
Yang M, 2011, CURR PROTOC NEUROSCI, V8, P8
Zbuk KM, 2007, NAT REV CANCER, V7, P35, DOI 10.1038/nrc2037
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
Zhou XP, 2003, AM J HUM GENET, V73, P1191, DOI 10.1086/379382
Zhu Y, 2001, GENE DEV, V15, P859, DOI 10.1101/gad.862101
NR 56
TC 2
Z9 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD JUN 15
PY 2014
VL 23
IS 12
BP 3212
EP 3227
DI 10.1093/hmg/ddu031
PG 16
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AI7CJ
UT WOS:000337038600013
PM 24470394
ER
PT J
AU Ludwig, AL
Espinal, GM
Pretto, DI
Jamal, AL
Arque, G
Tassone, F
Berman, RF
Hagerman, PJ
AF Ludwig, Anna Lisa
Espinal, Glenda M.
Pretto, Dalyir I.
Jamal, Amanda L.
Arque, Gloria
Tassone, Flora
Berman, Robert F.
Hagerman, Paul J.
TI CNS expression of murine fragile X protein (FMRP) as a function of
CGG-repeat size
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID TREMOR/ATAXIA SYNDROME FXTAS; KNOCK-IN MICE; MESSENGER-RNA; MOUSE MODEL;
PREMUTATION CARRIERS; FULL-MUTATION; FRAGILE-X-MENTAL-RETARDATION-1
GENE; INTRANUCLEAR INCLUSIONS; ELEVATED LEVELS; NEURAL CELLS
AB Large expansions of a CGG-repeat element (> 200 repeats; full mutation) in the fragile X mental retardation 1 (FMR1) gene cause fragile X syndrome (FXS), the leading single-gene form of intellectual disability and of autism spectrum disorder. Smaller expansions (55-200 CGG repeats; premutation) result in the neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS). Whereas FXS is caused by gene silencing and insufficient FMR1 protein (FMRP), FXTAS is thought to be caused by 'toxicity' of expanded-CGG-repeat mRNA. However, as FMRP expression levels decrease with increasing CGG-repeat length, lowered protein may contribute to premutation-associated clinical involvement. To address this issue, we measured brain Fmr1 mRNA and FMRP levels as a function of CGG-repeat length in a congenic (CGG-repeat knock-in) mouse model using 57 wild-type and 97 expanded-CGG-repeat mice carrying up to similar to 250 CGG repeats. While Fmr1 message levels increased with repeat length, FMRP levels trended downward over the same range, subject to significant inter-subject variation. Human comparisons of protein levels in the frontal cortex of 7 normal and 17 FXTAS individuals revealed that the mild FMRP decrease in mice mirrored the more limited data for FMRP expression in the human samples. In addition, FMRP expression levels varied in a subset of mice across the cerebellum, frontal cortex, and hippocampus, as well as at different ages. These results provide a foundation for understanding both the CGG-repeat-dependence of FMRP expression and for interpreting clinical phenotypes in premutation carriers in terms of the balance between elevated mRNA and lowered FMRP expression levels.
C1 [Ludwig, Anna Lisa; Espinal, Glenda M.; Pretto, Dalyir I.; Tassone, Flora; Hagerman, Paul J.] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Davis, CA 95616 USA.
[Pretto, Dalyir I.; Tassone, Flora; Berman, Robert F.; Hagerman, Paul J.] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
[Jamal, Amanda L.; Arque, Gloria; Berman, Robert F.] Univ Calif Davis, Sch Med, Dept Neurol Surg, Davis, CA 95616 USA.
RP Hagerman, PJ (reprint author), Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, 4303 Tupper Hall,One Shields Ave, Davis, CA 95616 USA.
EM pjhagerman@ucdavis.edu
FU National Institutes of Health [R01HD040661, R01NS079775]
FX This work was supported by the National Institutes of Health (grant
numbers R01HD040661 to P.J.H. and R01NS079775 to R.F.B.).
CR ABITBOL M, 1993, NAT GENET, V4, P147, DOI 10.1038/ng0693-147
Allen EG, 2004, HUM GENET, V114, P439, DOI 10.1007/s00439-004-1086-x
Apartis E, 2012, NEUROLOGY, V79, P1898, DOI 10.1212/WNL.0b013e318271f7ff
Arocena DG, 2005, HUM MOL GENET, V14, P3661, DOI 10.1093/hmg/ddi394
BACHNER D, 1993, HUM MOL GENET, V2, P2043, DOI 10.1093/hmg/2.12.2043
Berman RF, 2012, EPILEPSIA, V53, P150, DOI 10.1111/j.1528-1167.2012.03486.x
Berman RF, 2009, J INVEST MED, V57, P837, DOI 10.231/JIM.0b013e3181af59d6
Bontekoe CJM, 2001, HUM MOL GENET, V10, P1693, DOI 10.1093/hmg/10.16.1693
Brouwer JR, 2008, PSYCHONEUROENDOCRINO, V33, P863, DOI 10.1016/j.psyneuen.2008.03.011
Brouwer JR, 2007, EXP CELL RES, V313, P244, DOI 10.1016/j.yexcr.2006.10.002
Brouwer JR, 2008, J NEUROCHEM, V107, P1671, DOI 10.1111/j.1471-4159.2008.05747.x
Chen LS, 2003, HUM MOL GENET, V12, P3067, DOI 10.1093/hmg/ddg331
Chen YC, 2010, HUM MOL GENET, V19, P196, DOI 10.1093/hmg/ddp479
Diep AA, 2012, NEUROBIOL LEARN MEM, V97, P229, DOI 10.1016/j.nlm.2011.12.006
Entezam A, 2007, GENE, V395, P125, DOI 10.1016/j.gene.2007.02.026
Ericsson C, 2011, METHODS MOL BIOL, V675, P307, DOI 10.1007/978-1-59745-423-0_17
FU YH, 1991, CELL, V67, P1047, DOI 10.1016/0092-8674(91)90283-5
Garcia-Arocena D, 2010, HUM MOL GENET, V19, P299, DOI 10.1093/hmg/ddp497
Greco CM, 2006, BRAIN, V129, P243, DOI 10.1093/brain/awh683
Hagerman P, 2013, ACTA NEUROPATHOL, V126, P1, DOI 10.1007/s00401-013-1138-1
Hagerman PJ, 2004, MENT RETARD DEV D R, V10, P25, DOI 10.1002/mrdd.20005
Hagerman RJ, 2001, NEUROLOGY, V57, P127
Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
Hantash FM, 2011, GENET MED, V13, P39, DOI 10.1097/GIM.0b013e3181fa9fad
Hashem V, 2009, HUM MOL GENET, V18, P2443, DOI 10.1093/hmg/ddp182
HINDS HL, 1993, NAT GENET, V3, P36, DOI 10.1038/ng0193-36
Hunsaker MR, 2011, J NEUROPATH EXP NEUR, V70, P462, DOI 10.1097/NEN.0b013e31821d3194
Hunsaker MR, 2010, BEHAV BRAIN RES, V213, P263, DOI 10.1016/j.bbr.2010.05.010
Hunsaker MR, 2011, ACTA NEUROPATHOL, V122, P467, DOI 10.1007/s00401-011-0860-9
Hunsaker MR, 2009, BEHAV NEUROSCI, V123, P1315, DOI 10.1037/a0017616
Hunsaker MR, 2011, BEHAV BRAIN RES, V222, P117, DOI 10.1016/j.bbr.2011.03.039
Iwahashi C, 2009, J MOL DIAGN, V11, P281, DOI 10.2353/jmoldx.2009.080118
Jacquemont S, 2003, AM J HUM GENET, V72, P869, DOI 10.1086/374321
Jin P, 2003, NEURON, V39, P739, DOI 10.1016/S0896-6273(03)00533-6
Juncos JL, 2011, NEUROGENETICS, V12, P123, DOI 10.1007/s10048-010-0270-5
Kenneson A, 2001, HUM MOL GENET, V10, P1449, DOI 10.1093/hmg/10.14.1449
KHANDJIAN EW, 1995, HUM MOL GENET, V4, P783, DOI 10.1093/hmg/4.5.783
LAEMMLI UK, 1973, J MOL BIOL, V80, P575, DOI 10.1016/0022-2836(73)90198-8
Leehey Maureen A, 2012, Handb Clin Neurol, V103, P373, DOI 10.1016/B978-0-444-51892-7.00023-1
Leehey MA, 2011, RHEUMATOLOGY, V50, P2233, DOI 10.1093/rheumatology/ker273
Lessard M, 2012, CLIN GENET, V82, P472, DOI 10.1111/j.1399-0004.2011.01798.x
Loesch DZ, 2004, MENT RETARD DEV D R, V10, P31, DOI 10.1002/mrdd.20006
Ludwig AL, 2011, J MOL BIOL, V407, P21, DOI 10.1016/j.jmb.2011.01.006
Luo YP, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000898
Maenner MJ, 2013, AM J MED GENET B, V162B, P466, DOI 10.1002/ajmg.b.32176
Napierala M, 2005, NUCLEIC ACIDS RES, V33, P451, DOI 10.1093/nar/gki186
Peprah E, 2010, J HUM GENET, V55, P66, DOI 10.1038/jhg.2009.121
PIERETTI M, 1991, CELL, V66, P817, DOI 10.1016/0092-8674(91)90125-I
Primerano B, 2002, RNA, V8, P1482, DOI 10.1017/s1355838202020642
Qin M, 2011, NEUROBIOL DIS, V42, P85, DOI 10.1016/j.nbd.2011.01.008
Rasband W. S., 1997, IMAGEJ
Saffary R, 2011, J NEUROSCI, V31, P1427, DOI 10.1523/JNEUROSCI.4854-10.2011
Saluto A, 2005, J MOL DIAGN, V7, P605, DOI 10.1016/S1525-1578(10)60594-6
Schneider A, 2009, DEV DISABIL RES REV, V15, P333, DOI 10.1002/ddrr.80
SCHWARTZ CE, 1994, AM J MED GENET, V51, P400, DOI 10.1002/ajmg.1320510419
Sullivan SD, 2011, SEMIN REPROD MED, V29, P299, DOI 10.1055/s-0031-1280915
Tassone F, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.012518
Tassone F, 2003, CYTOGENET GENOME RES, V100, P124, DOI 10.1159/000072846
Tassone F, 2012, GENOME MED, V4, P1
Tassone F, 2000, AM J HUM GENET, V66, P6, DOI 10.1086/302720
Tassone F, 2000, AM J MED GENET, V94, P232, DOI 10.1002/1096-8628(20000918)94:3<232::AID-AJMG9>3.0.CO;2-H
Tassone F, 2012, GENOME MED, V4, DOI 10.1186/gm401
Tassone F, 2007, RNA, V13, P555, DOI 10.1261/rna.280807
Van Dam D, 2005, BEHAV BRAIN RES, V162, P233, DOI 10.1016/j.bbr.2005.03.007
Wang JY, 2013, NEUROIMAGE, V65, P288, DOI 10.1016/j.neuroimage.2012.09.075
Wenzel HJ, 2010, BRAIN RES, V1318, P155, DOI 10.1016/j.brainres.2009.12.077
Willemsen R, 2003, HUM MOL GENET, V12, P949, DOI 10.1093/hmg/ddg114
Zumwalt M, 2007, RNA BIOL, V4, P93
NR 68
TC 8
Z9 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD JUN 15
PY 2014
VL 23
IS 12
BP 3228
EP 3238
DI 10.1093/hmg/ddu032
PG 11
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AI7CJ
UT WOS:000337038600014
PM 24463622
ER
PT J
AU Burette, AC
Park, H
Weinberg, RJ
AF Burette, Alain C.
Park, Haram
Weinberg, Richard J.
TI Postsynaptic Distribution of IRSp53 in Spiny Excitatory and Inhibitory
Neurons
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE dendritic spine; PSD; BAIAP2; Rho GTPase; GABAergic neurons
ID INSULIN-RECEPTOR SUBSTRATE; LONG-TERM DEPRESSION; MEDIATED
SYNAPTIC-TRANSMISSION; TYROSINE KINASE; PROTEOMIC ANALYSIS; DENDRITIC
SPINE; NMDA RECEPTORS; NERVOUS-SYSTEM; ACTIN DYNAMICS; RAT-BRAIN
AB The 53 kDa insulin receptor substrate protein (IRSp53) is highly enriched in the brain. Despite evidence that links mutations of IRSp53 with autism and other neuropsychiatric problems, the functional significance of this protein remains unclear. We used light and electron microscopic immunohistochemistry to demonstrate that IRSp53 is expressed throughout the adult rat brain. Labeling concentrated selectively in dendritic spines, where it was associated with the postsynaptic density (PSD). Surprisingly, its organization within the PSD of spiny excitatory neurons of neocortex and hippocampus differed from that within spiny inhibitory neurons of neostriatum and cerebellar cortex. The present data support previous suggestions that IRSp53 is involved in postsynaptic signaling, while hinting that its signaling role may differ in different types of neurons. J. Comp. Neurol. 522:2164-2178, 2014. (c) 2013 Wiley Periodicals, Inc.
C1 [Burette, Alain C.; Weinberg, Richard J.] Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA.
[Park, Haram] Korea Adv Inst Sci & Technol, Inst Basic Sci, Ctr Synapt Brain Dysfunct, Taejon 305701, South Korea.
[Park, Haram] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea.
[Weinberg, Richard J.] Univ N Carolina, Neurosci Ctr, Chapel Hill, NC 27599 USA.
RP Burette, AC (reprint author), Univ N Carolina, Dept Cell Biol & Physiol, CB 7090, Chapel Hill, NC 27599 USA.
EM alain.burette@gmail.com
FU National Institutes of Health (NIH) [R01 NS039444]
FX Grant sponsor: National Institutes of Health (NIH); Grant number: R01
NS039444 (to R.J.W.).
CR Abbott MA, 1999, J NEUROSCI, V19, P7300
Ahmed S, 2010, SEMIN CELL DEV BIOL, V21, P350, DOI 10.1016/j.semcdb.2009.11.008
Banks WA, 2012, PHARMACOL THERAPEUT, V136, P82, DOI 10.1016/j.pharmthera.2012.07.006
Beattie EC, 2000, NAT NEUROSCI, V3, P1291
Bockmann J, 2002, J NEUROCHEM, V83, P1013, DOI 10.1046/j.1471-4159.2002.01204.x
Cheng DM, 2006, MOL CELL PROTEOMICS, V5, P1158, DOI 10.1074/mcp.D500009-MCP200
Chiu SL, 2008, NEURON, V58, P708, DOI 10.1016/j.neuron.2008.04.014
Chiu SL, 2010, NEURAL DEV, V5, DOI 10.1186/1749-8104-5-7
Choi J, 2005, J NEUROSCI, V25, P869, DOI 10.1523/JNEUROSCI.3212-04.2005
Dosemeci A, 2007, MOL CELL PROTEOMICS, V6, P1749, DOI 10.1074/mcp.M700040-MCP200
Dou JT, 2005, LEARN MEMORY, V12, P646, DOI 10.1101/lm.88005
Ghasemi R, 2013, MOL NEUROBIOL, V47, P145, DOI 10.1007/s12035-012-8339-9
Govind S, 2001, J CELL BIOL, V152, P579, DOI 10.1083/jcb.152.3.579
Harris KM, 2012, COLD SPRING HARBOR P, V4
HAVRANKOVA J, 1978, NATURE, V272, P827, DOI 10.1038/272827a0
Hori K, 2005, J NEUROSCI, V25, P2670, DOI 10.1523/JNEUROSCI.3638-04.2005
Huang CC, 2003, MOL CELL NEUROSCI, V24, P831, DOI 10.1016/S1044-7431(03)00238-0
Huang CC, 2004, J NEUROCHEM, V89, P217, DOI 10.1111/j.1471-4159.2003.02307.x
Husi H, 2000, NAT NEUROSCI, V3, P661
Kharazia VN, 1999, J COMP NEUROL, V412, P292, DOI 10.1002/(SICI)1096-9861(19990920)412:2<292::AID-CNE8>3.0.CO;2-G
Kim MH, 2009, J NEUROSCI, V29, P1586, DOI 10.1523/JNEUROSCI.4306-08.2009
Krugmann S, 2001, CURR BIOL, V11, P1645, DOI 10.1016/S0960-9822(01)00506-1
Lee CC, 2011, NEUROPHARMACOLOGY, V61, P867, DOI 10.1016/j.neuropharm.2011.06.003
Liao GY, 1999, J NEUROCHEM, V73, P1510, DOI 10.1046/j.1471-4159.1999.0731510.x
Lim KB, 2008, J BIOL CHEM, V283, P20454, DOI 10.1074/jbc.M710185200
Man HY, 2000, NEURON, V25, P649, DOI 10.1016/S0896-6273(00)81067-3
MARKS JL, 1990, ENDOCRINOLOGY, V127, P3234
Miki H, 2000, NATURE, V408, P732
Nakagawa H, 2003, J CELL SCI, V116, P2577, DOI 10.1242/jcs.00462
Oda K, 1999, CYTOGENET CELL GENET, V84, P75, DOI 10.1159/000015219
O'Rourke NA, 2012, NAT REV NEUROSCI, V13, P365, DOI 10.1038/nrn3170
Paschou P, 2004, AM J HUM GENET, V75, P545, DOI 10.1086/424389
Passafaro M, 2001, NAT NEUROSCI, V4, P917, DOI 10.1038/nn0901-917
PETRALIA RS, 1994, J NEUROSCI, V14, P6102
Ribases M, 2009, BIOL PSYCHIAT, V66, P926, DOI 10.1016/j.biopsych.2009.06.024
Sawallisch C, 2009, J BIOL CHEM, V284, P9225, DOI 10.1074/jbc.M808425200
Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
Scita G, 2008, TRENDS CELL BIOL, V18, P52, DOI 10.1016/j.tcb.2007.12.002
Sekerkova G, 2003, J NEUROSCI, V23, P1310
SHU SY, 1988, NEUROSCI LETT, V85, P169, DOI 10.1016/0304-3940(88)90346-1
Skeberdis VA, 2001, P NATL ACAD SCI USA, V98, P3561, DOI 10.1073/pnas.051634698
Soltau M, 2002, MOL CELL NEUROSCI, V21, P575, DOI 10.1006/mcne.2002.1201
Soltau M, 2004, J NEUROCHEM, V90, P659, DOI 10.1111/j.1471-4159.2004.02523.x
Takumi Y, 1999, NAT NEUROSCI, V2, P618
Toma C, 2011, J PSYCHIATR RES, V45, P280, DOI 10.1016/j.jpsychires.2010.09.001
Valtschanoff JG, 2001, J NEUROSCI, V21, P1211
Wan Q, 1997, NATURE, V388, P686
Wang YT, 2000, NEURON, V25, P635, DOI 10.1016/S0896-6273(00)81066-1
WERTHER GA, 1987, ENDOCRINOLOGY, V121, P1562
Yamagishi A, 2004, J BIOL CHEM, V279, P14929, DOI 10.1074/jbc.M309408200
Yeh TC, 1996, J BIOL CHEM, V271, P2921
Zhao HX, 2011, CURR OPIN CELL BIOL, V23, P14, DOI 10.1016/j.ceb.2010.10.005
Zhao WQ, 1999, J BIOL CHEM, V274, P34893, DOI 10.1074/jbc.274.49.34893
Zhou JY, 2013, CLIN CHIM ACTA, V420, P62, DOI 10.1016/j.cca.2013.03.016
NR 54
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9967
EI 1096-9861
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD JUN 15
PY 2014
VL 522
IS 9
BP 2164
EP 2178
DI 10.1002/cne.23526
PG 15
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA AF1QS
UT WOS:000334489000012
PM 24639075
ER
PT J
AU Sadakata, T
Kakegawa, W
Shinoda, Y
Hosono, M
Katoh-Semba, R
Sekine, Y
Sato, Y
Saruta, C
Ishizaki, Y
Yuzaki, M
Kojima, M
Furuichi, T
AF Sadakata, Tetsushi
Kakegawa, Wataru
Shinoda, Yo
Hosono, Mayu
Katoh-Semba, Ritsuko
Sekine, Yukiko
Sato, Yumi
Saruta, Chihiro
Ishizaki, Yasuki
Yuzaki, Michisuke
Kojima, Masami
Furuichi, Teiichi
TI Axonal Localization of Ca2+- Dependent Activator Protein for Secretion 2
Is Critical for Subcellular Locality of Brain-Derived Neurotrophic
Factor and Neurotrophin-3 Release Affecting Proper Development of
Postnatal Mouse Cerebellum
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; CORE VESICLE TRAFFICKING; DIFFERENTIAL
REGULATION; CADPS2-KNOCKOUT MICE; SYNAPTIC PLASTICITY; RETT-SYNDROME;
CADPS2; BDNF; CALCIUM; CAPS1
AB Ca2+-dependent activator protein for secretion 2 (CAPS2) is a protein that is essential for enhanced release of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from cerebellar granule cells. We previously identified dex3, a rare alternative splice variant of CAPS2, which is overrepresented in patients with autism and is missing an exon 3 critical for axonal localization. We recently reported that a mouse model CAPS2(Delta ex3/Delta ex3) expressing dex3 showed autistic-like behavioral phenotypes including impaired social interaction and cognition and increased anxiety in an unfamiliar environment. Here, we verified impairment in axonal, but not somato-dendritic, localization of dex3 protein in cerebellar granule cells and demonstrated cellular and physiological phenotypes in postnatal cerebellum of CAPS2(Delta ex3/Delta ex3) mice. Interestingly, both BDNF and NT-3 were markedly reduced in axons of cerebellar granule cells, resulting in a significant decrease in their release. As a result, dex3 mice showed developmental deficits in dendritic arborization of Purkinje cells, vermian lobulation and fissurization, and granule cell precursor proliferation. Paired-pulse facilitation at parallel fiber-Purkinje cell synapses was also impaired. Together, our results indicate that CAPS2 plays an important role in subcellular locality (axonal vs. somato-dendritic) of enhanced BDNF and NT-3 release, which is indispensable for proper development of postnatal cerebellum.
C1 [Sadakata, Tetsushi; Hosono, Mayu] Gunma Univ, Adv Sci Res Leaders Dev Unit, Maebashi, Gunma, Japan.
[Sadakata, Tetsushi; Shinoda, Yo; Kojima, Masami; Furuichi, Teiichi] JST CREST, Kawaguchi, Saitama, Japan.
[Kakegawa, Wataru; Yuzaki, Michisuke] Keio Univ, Sch Med, Dept Physiol, Tokyo 160, Japan.
[Shinoda, Yo; Katoh-Semba, Ritsuko; Sekine, Yukiko; Sato, Yumi; Saruta, Chihiro; Furuichi, Teiichi] Tokyo Univ Sci, Dept Appl Biol Sci, Noda, Chiba 278, Japan.
[Ishizaki, Yasuki] Gunma Univ, Grad Sch Med, Dept Mol & Cellular Neurobiol, Maebashi, Gunma, Japan.
[Kojima, Masami] Natl Inst Adv Ind Sci & Technol, Hlth Res Inst, Biointerface Res Grp, Ikeda, Osaka, Japan.
RP Sadakata, T (reprint author), Gunma Univ, Adv Sci Res Leaders Dev Unit, Maebashi, Gunma, Japan.
EM sadakata-1024@umin.ac.jp; tfuruichi@rs.tus.ac.jp
RI Yuzaki, Michisuke/K-5328-2013
OI Yuzaki, Michisuke/0000-0002-5750-3544
FU Japan Foundation for Neuroscience and Mental Health; Uehara Memorial
Foundation; Takeda Science Foundation; Nakajima Foundation; Yamada
Science Foundation; Mother and Child Health Foundation; NOVARTIS
Foundation for the Promotion of Science; Inamori Foundation; Scientific
Research on Innovative Areas "Foundation of Synapse and Neurocircuit
Pathology''; Japan Science and Technology Agency; Japanese Ministry of
Education, Culture, Sports, Science and Technology (MEXT) [25110707];
Japan Society for the Promotion of Science (JSPS) [25430061]; Institute
of Physical and Chemical Research (RIKEN); Program to Disseminate Tenure
Tracking System of MEXT
FX This study was supported by Grants-in-Aid for Scientific Research from
the Japan Foundation for Neuroscience and Mental Health, the Uehara
Memorial Foundation, the Takeda Science Foundation, the Nakajima
Foundation, the Yamada Science Foundation, the Mother and Child Health
Foundation, the NOVARTIS Foundation for the Promotion of Science, the
Inamori Foundation, Scientific Research on Innovative Areas "Foundation
of Synapse and Neurocircuit Pathology'', the Japan Science and
Technology Agency, the Japanese Ministry of Education, Culture, Sports,
Science and Technology (MEXT; grant number 25110707), the Japan Society
for the Promotion of Science (JSPS; grant numbers 25430061), the
Institute of Physical and Chemical Research (RIKEN), and the Program to
Disseminate Tenure Tracking System of MEXT granted to Gunma University.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR Amir RE, 1999, NAT GENET, V23, P185
Atluri PP, 1998, J NEUROSCI, V18, P8214
Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
Bates B, 1999, NAT NEUROSCI, V2, P115, DOI 10.1038/5669
Bibel M, 2000, GENE DEV, V14, P2919, DOI 10.1101/gad.841400
Binda AV, 2005, BIOCHEM PHARMACOL, V69, P1451, DOI 10.1016/j.bcp.2005.02.015
Bonora E, 2014, EMBO MOL MED
Carter AR, 2002, J NEUROSCI, V22, P1316
Chang QA, 2006, NEURON, V49, P341, DOI 10.1016/j.neuron.2005.12.027
Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
Cisternas FA, 2003, GENOMICS, V81, P279, DOI 10.1016/S0888-7543(02)00040-X
COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
Eran A, 2009, J CLIN INVEST, V119, P679, DOI 10.1172/JCI38620
Grishanin RN, 2004, NEURON, V43, P551, DOI 10.1016/j.neuron.2004.07.028
Palferman S, 2001, HUM MOL GENET, V10, P973
Ito M, 2001, PHYSIOL REV, V81, P1143
Kakegawa W, 2008, J NEUROSCI, V28, P1460, DOI 10.1523/JNEUROSCI.2553-07.2008
Katoh-Semba R, 2000, J NEUROCHEM, V74, P1923, DOI 10.1046/j.1471-4159.2000.0741923.x
KatohSemba R, 1996, J NEUROCHEM, V66, P330
Lu B, 2003, LEARN MEMORY, V10, P86, DOI 10.1101/lm.54603
Moretti P, 2006, J NEUROSCI, V26, P319, DOI 10.1523/JNEUROSCI.2623-05.2006
Okamoto N, 2011, AM J MED GENET A, V155A, P1568, DOI 10.1002/ajmg.a.34028
Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
Sadakata T, 2013, J NEUROSCI, V33, P17326, DOI 10.1523/JNEUROSCI.2777-13.2013
Sadakata T, 2004, J NEUROSCI, V24, P43, DOI 10.1523/JNEUROSCI.2528-03.2004
Sadakata T, 2010, J BIOL CHEM, V285, P38710, DOI 10.1074/jbc.M110.137414
Sadakata T, 2007, J CLIN INVEST, V117, P931, DOI 10.1172/JCI29031
Sadakata T, 2012, P NATL ACAD SCI USA, V109, P21104, DOI 10.1073/pnas.1210055109
Sadakata T, 2007, J NEUROSCI, V27, P2472, DOI 10.1523/JNEUROSCI.2279-06.2007
Sadakata T, 2009, CEREBELLUM, V8, P312, DOI 10.1007/s12311-009-0097-5
Schwartz PM, 1997, NEURON, V19, P269, DOI 10.1016/S0896-6273(00)80938-1
Shinoda Y, 2010, P NATL ACAD SCI USA, V108, P373
Speidel D, 2005, NEURON, V46, P75, DOI 10.1016/j.neuron.2005.02.019
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Tandon A, 1998, NEURON, V21, P147, DOI 10.1016/S0896-6273(00)80522-X
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
NR 36
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 12
PY 2014
VL 9
IS 6
AR e99524
DI 10.1371/journal.pone.0099524
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK8TP
UT WOS:000338701300071
PM 24923991
ER
PT J
AU Zhou, YX
Yu, F
Duong, T
AF Zhou, Yongxia
Yu, Fang
Duong, Timothy
TI Multiparametric MRI Characterization and Prediction in Autism Spectrum
Disorder Using Graph Theory and Machine Learning
SO PLOS ONE
LA English
DT Article
ID INFERIOR FRONTAL GYRUS; FUNCTIONAL CONNECTIVITY; CORTICAL THICKNESS;
FEATURE-SELECTION; BRAIN; CHILDREN; CORTEX; AGE; FLUCTUATIONS;
PERFORMANCE
AB This study employed graph theory and machine learning analysis of multiparametric MRI data to improve characterization and prediction in autism spectrum disorders (ASD). Data from 127 children with ASD (13.5 +/- 6.0 years) and 153 age- and gender-matched typically developing children (14.5 +/- 5.7 years) were selected from the multi-center Functional Connectome Project. Regional gray matter volume and cortical thickness increased, whereas white matter volume decreased in ASD compared to controls. Small-world network analysis of quantitative MRI data demonstrated decreased global efficiency based on gray matter cortical thickness but not with functional connectivity MRI (fcMRI) or volumetry. An integrative model of 22 quantitative imaging features was used for classification and prediction of phenotypic features that included the autism diagnostic observation schedule, the revised autism diagnostic interview, and intelligence quotient scores. Among the 22 imaging features, four (caudate volume, caudate-cortical functional connectivity and inferior frontal gyrus functional connectivity) were found to be highly informative, markedly improving classification and prediction accuracy when compared with the single imaging features. This approach could potentially serve as a biomarker in prognosis, diagnosis, and monitoring disease progression.
C1 [Zhou, Yongxia] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA.
[Yu, Fang; Duong, Timothy] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, South Texas Vet Hlth Care Syst, Dept Vet Affairs,Dept Ophthalmol, San Antonio, TX 78229 USA.
RP Duong, T (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, South Texas Vet Hlth Care Syst, Dept Vet Affairs,Dept Ophthalmol, San Antonio, TX 78229 USA.
EM duongt@uthscsa.edu
CR Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Bastiaansen JA, 2011, BIOL PSYCHIAT, V69
Buitelaar JK, 1999, J CHILD PSYCHOL PSYC, V40, P869, DOI 10.1017/S0021963099004321
Depretto M, 2006, NAT NEUROSCI, V9, P28
Di Martino A., 2013, MOL PSYCHIATR, DOI [10.1038/mp.2013.78, DOI 10.1038/MP.2013.78]
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
Duchesnay E, 2011, NEUROIMAGE, V57, P1003, DOI 10.1016/j.neuroimage.2011.05.011
Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
Ecker C, 2009, NEUROREPORT, V20, P1155, DOI 10.1097/WNR.0b013e32832ec181
Ecker C, 2013, JAMA PSYCHIAT, V70, P59, DOI 10.1001/jamapsychiatry.2013.265
Elliott MA, 1999, MAGNET RESON MED, V41, P450, DOI 10.1002/(SICI)1522-2594(199903)41:3<450::AID-MRM4>3.0.CO;2-9
Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
Fischl B, 2012, NEUROIMAGE, V62, P774, DOI 10.1016/j.neuroimage.2012.01.021
Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083
Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
Gagliardi F, 2011, ARTIF INTELL MED, V52, P123, DOI 10.1016/j.artmed.2011.04.002
Gallese V, 2013, DEV MED CHILD NEUROL, V55, P15, DOI 10.1111/j.1469-8749.2012.04398.x
Geva S, BRAIN, V134, P3071
Greenlee JDW, 2007, J COMP NEUROL, V503, P550, DOI 10.1002/cne.21405
Hamilton AFD, 2013, DEV COGN NEUROS-NETH, V3, P91, DOI 10.1016/j.dcn.2012.09.008
Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
Hinton GE, 2006, NEURAL COMPUT, V18, P1527, DOI 10.1162/neco.2006.18.7.1527
Hsieh L, 2001, BRAIN LANG, V76, P227, DOI 10.1006/brln.2000.2382
Huang Y Y, 1983, Sheng Li Ke Xue Jin Zhan, V14, P356
Jakab A, 2013, PLOS ONE, V8, P1
Kang S, 2013, RES DEV DISABIL, V34, P739, DOI 10.1016/j.ridd.2012.10.007
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
Khan S, 2013, P NATL ACAD SCI USA, V110, P3107, DOI 10.1073/pnas.1214533110
Lange N, 2010, AUTISM RES, V3, P350, DOI 10.1002/aur.162
Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040
Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
Nixon P, 2004, J COGNITIVE NEUROSCI, V16, P289, DOI 10.1162/089892904322984571
Peng HC, 2005, IEEE T PATTERN ANAL, V27, P1226
Peters JM, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-54
Rapin I, 2008, PEDIATR CLIN N AM, V55, P1129, DOI 10.1016/j.pcl.2008.07.005
Rizzolatti G, 2010, EXP BRAIN RES, V200, P223, DOI 10.1007/s00221-009-2002-3
Rudie JD, CEREB CORTEX, V22, P1025
Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013
Sivaswamy L, 2010, J CHILD NEUROL, V25, P1223, DOI 10.1177/0883073809358765
Sowell ER, 2007, CEREB CORTEX, V17, P1550, DOI 10.1093/cercor/bhl066
Stark DE, 2008, J NEUROSCI, V28, P13754, DOI 10.1523/JNEUROSCI.4544-08.2008
Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
Turner Katherine C, 2006, Behav Brain Funct, V2, P34, DOI 10.1186/1744-9081-2-34
Uddin LQ, 2013, FRONT HUM NEUROSCI, V7, P1
van der Zande FHR, 2005, NEURORADIOLOGY, V47, P114, DOI 10.1007/s00234-004-1274-3
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
Walsh CA, 2008, CELL, V135, P396, DOI 10.1016/j.cell.2008.10.015
WANG H, 2012, PLOS ONE, V0007
Zhou Y, 2013, AM J NEURORADIOL, V34, P1180, DOI 10.3174/ajnr.A3386
Zhou Y, 2013, ISRN GERIATRICS, V2013
Zhou YX, 2014, J MAGN RESON IMAGING, V39, P1558, DOI 10.1002/jmri.24310
NR 56
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 12
PY 2014
VL 9
IS 6
AR e90405
DI 10.1371/journal.pone.0090405
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK8TP
UT WOS:000338701300001
PM 24922325
ER
PT J
AU Kassai, H
Sugaya, Y
Noda, S
Nakao, K
Maeda, T
Kano, M
Aiba, A
AF Kassai, Hidetoshi
Sugaya, Yuki
Noda, Shoko
Nakao, Kazuki
Maeda, Tatsuya
Kano, Masanobu
Aiba, Atsu
TI Selective Activation of mTORC1 Signaling Recapitulates Microcephaly,
Tuberous Sclerosis, and Neurodegenerative Diseases
SO CELL REPORTS
LA English
DT Article
ID FRAGILE-X-SYNDROME; MAMMALIAN TARGET; CELL-PROLIFERATION;
NERVOUS-SYSTEM; MOUSE MODELS; RAPAMYCIN; COMPLEX; BRAIN; AUTOPHAGY;
NEURONS
AB Mammalian target of rapamycin (mTOR) has been implicated in human neurological diseases such as tuberous sclerosis complex (TSC), neurodegeneration, and autism. However, little is known about when and how mTOR is involved in the pathogenesis of these diseases, due to a lack of animal models that directly increase mTOR activity. Here, we generated transgenic mice expressing a gain-of-function mutant of mTOR in the forebrain in a temporally controlled manner. Selective activation of mTORC1 in embryonic stages induced cortical atrophy caused by prominent apoptosis of neuronal progenitors, associated with upregulation of HIF-1 alpha. In striking contrast, activation of the mTORC1 pathway in adulthood resulted in cortical hypertrophy with fatal epileptic seizures, recapitulating human TSC. Activated mTORC1 in the adult cortex also promoted rapid accumulation of cytoplasmic inclusions and activation of microglial cells, indicative of progressive neurodegeneration. Our findings demonstrate that mTORC1 plays different roles in developmental and adult stages and contributes to human neurological diseases.
C1 [Kassai, Hidetoshi; Noda, Shoko; Nakao, Kazuki; Aiba, Atsu] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Lab Anim Resources, Tokyo 1130033, Japan.
[Sugaya, Yuki; Kano, Masanobu] Univ Tokyo, Grad Sch Med, Dept Neurophysiol, Tokyo 1130033, Japan.
[Nakao, Kazuki] RIKEN Ctr Dev Biol, Lab Anim Resources & Genet Engn, Kobe, Hyogo 6500047, Japan.
[Maeda, Tatsuya] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan.
RP Aiba, A (reprint author), Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Lab Anim Resources, Tokyo 1130033, Japan.
EM aiba@m.u-tokyo.ac.jp
FU Japan Society for the Promotion of Science [22300106, 21220006,
25000015, 25291042, 23700368]; Strategic Research Program for Brain
Sciences (Development of Biomarker Candidates for Social Behavior),
MEXT, Japan
FX We thank Drs. Shigeo Okabe (The University of Tokyo) and Makoto Sato
(Osaka University) for providing valuable advice and plasmids for in
utero electroporation experiments. We also thank Drs. Terunao Takahara
and Yoichiro Ohne for helpful discussions. This study was supported in
part by Grants-in-Aid for Scientific Research (22300106 to A. A.,
21220006 and 25000015 to M. K., and 25291042 to T. M.) and for Young
Scientists (B) (23700368 to H. K.) from the Japan Society for the
Promotion of Science. This study was also partially supported by the
Strategic Research Program for Brain Sciences (Development of Biomarker
Candidates for Social Behavior), MEXT, Japan.
CR BEBIN EM, 1993, EPILEPSIA, V34, P651, DOI 10.1111/j.1528-1157.1993.tb00442.x
Bove J, 2011, NAT REV NEUROSCI, V12, P437, DOI 10.1038/nrn3068
Busquets-Garcia A, 2013, NAT MED, V19, P603, DOI 10.1038/nm.3127
Carmeliet P, 1998, NATURE, V394, P485, DOI 10.1038/28867
Carson RP, 2012, NEUROBIOL DIS, V45, P369, DOI 10.1016/j.nbd.2011.08.024
Cloetta D, 2013, J NEUROSCI, V33, P7799, DOI 10.1523/JNEUROSCI.3294-12.2013
Cornu M, 2013, CURR OPIN GENET DEV, V23, P53, DOI 10.1016/j.gde.2012.12.005
Groszer M, 2001, SCIENCE, V294, P2186, DOI 10.1126/science.1065518
Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
Hara T, 2006, NATURE, V441, P885, DOI 10.1038/nature04724
Jaworski J, 2006, MOL NEUROBIOL, V34, P205, DOI 10.1385/MN:34:3:205
Kassai H, 2008, EUR J NEUROSCI, V28, P257, DOI 10.1111/j.1460-9568.2008.06343.x
Kim JY, 2009, NEURON, V63, P761, DOI 10.1016/j.neuron.2009.08.008
Komatsu M, 2006, NATURE, V441, P880, DOI 10.1038/nature04723
Land SC, 2007, J BIOL CHEM, V282, P20534, DOI 10.1074/jbc.M611782200
Laplante M, 2012, CELL, V149, P274, DOI 10.1016/j.cell.2012.03.017
Lee JH, 2012, NAT GENET, V44, P941, DOI 10.1038/ng.2329
Ljungberg MC, 2006, ANN NEUROL, V60, P420, DOI 10.1002/ana.20949
Magri L, 2011, CELL STEM CELL, V9, P447, DOI 10.1016/j.stem.2011.09.008
Maldonado M, 2003, NEUROBIOL DIS, V14, P279, DOI 10.1016/S0969-9961(03)00127-X
Mayford M, 1996, SCIENCE, V274, P1678, DOI 10.1126/science.274.5293.1678
McDonell LM, 2013, NAT GENET, V45, P556, DOI 10.1038/ng.2602
Meikle L, 2007, J NEUROSCI, V27, P5546, DOI 10.1523/JNEUROSCI.5540-06.2007
Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
Ohne Y, 2008, J BIOL CHEM, V283, P31861, DOI 10.1074/jbc.M801546200
Orlova KA, 2010, ANN NY ACAD SCI, V1184, P87, DOI 10.1111/j.1749-6632.2009.05117.x
Perry VH, 2010, NAT REV NEUROL, V6, P193, DOI 10.1038/nrneurol.2010.17
Pitkanen A, 2011, LANCET NEUROL, V10, P173, DOI 10.1016/S1474-4422(10)70310-0
Pun RYK, 2012, NEURON, V75, P1022, DOI 10.1016/j.neuron.2012.08.002
Ravikumar B, 2004, NAT GENET, V36, P585, DOI 10.1038/ng1362
Reith RM, 2011, NEUROBIOL DIS, V43, P113, DOI 10.1016/j.nbd.2011.02.014
Sancak Y, 2007, MOL CELL, V25, P903, DOI 10.1016/j.molcel.2007.03.003
Sato A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2295
Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
Sharp FR, 2004, NAT REV NEUROSCI, V5, P437, DOI 10.1038/nrn1408
Swiech L, 2008, BBA-PROTEINS PROTEOM, V1784, P116, DOI 10.1016/j.bbapap.2007.08.015
Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
Vander Haar E, 2007, NAT CELL BIOL, V9, P316, DOI 10.1038/ncb1547
Wang LF, 2007, J BIOL CHEM, V282, P20036, DOI 10.1074/jbc.M702376200
Way SW, 2009, HUM MOL GENET, V18, P1252, DOI 10.1093/hmg/ddp025
Wullschleger S, 2006, CELL, V124, P471, DOI 10.1016/j.cell.2006.01.016
YAMAGATA K, 1994, J BIOL CHEM, V269, P16333
Yang SB, 2012, NEURON, V75, P425, DOI 10.1016/j.neuron.2012.03.043
Zeng LH, 2007, NEUROBIOL DIS, V28, P184, DOI 10.1016/j.nbd.2007.07.015
Zhou J, 2011, GENE DEV, V25, P1595, DOI 10.1101/gad.16750211
Zou J, 2011, DEV CELL, V20, P97, DOI 10.1016/j.devcel.2010.11.020
NR 46
TC 3
Z9 5
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD JUN 12
PY 2014
VL 7
IS 5
BP 1626
EP 1639
DI 10.1016/j.celrep.2014.04.048
PG 14
WC Cell Biology
SC Cell Biology
GA AK3LA
UT WOS:000338324200027
PM 24857653
ER
PT J
AU Gallagher, S
AF Gallagher, Shaun
TI The cruel and unusual phenomenology of solitary confinement
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE solitary confinement; cruelty; intersubjectivity; induced autism; self
ID DEPRIVATION; OUTCOMES; SELF; MIND
AB What happens when subjects are deprived of intersubjective contact? This paper looks closely at the phenomenology and psychology of one example of that deprivation: solitary confinement. It also puts the phenomenology and psychology of solitary confinement to use in the legal context. Not only is there no consensus on whether solitary confinement is a "cruel and unusual punishment," there is no consensus on the definition of the term "cruel" in the use of that legal phrase. I argue that we can find a moral consensus on the meaning of "cruelty" by looking specifically at the phenomenology and psychology of solitary confinement.
C1 [Gallagher, Shaun] Univ Memphis, Dept Philosophy, Memphis, TN 38152 USA.
[Gallagher, Shaun] Univ Hertfordshire, Sch Humanities, Hatfield AL10 9AB, Herts, England.
[Gallagher, Shaun] Univ Wollongong, Fac Law Humanities & Arts, Wollongong, NSW, Australia.
RP Gallagher, S (reprint author), Univ Memphis, Dept Philosophy, 331 Clement Hall, Memphis, TN 38152 USA.
EM s.gallagher@memphis.edu
CR Berkson L. C., 1975, CONCEPT CRUEL UNUSUA
Blankenburg W., 1971, VERLUST NATURLICHEN
BONTA J, 1990, LAW HUMAN BEHAV, V14, P347, DOI 10.1007/BF01068161
Christensen E., 1999, 995 SOC
Code L., 2011, OXFORD HDB SELF, P694
Colvert E, 2008, J ABNORM CHILD PSYCH, V36, P1057, DOI 10.1007/s10802-008-9232-x
Dayan Colin, 2007, STORY CRUEL UNUSUAL
De Jaegher H., 2007, PHENOMENOLOGY COGNIT, V6, P485, DOI [DOI 10.1007/S11097-007-9076-9, 10.1007/s11097-007-9076-9]
De Jaegher H, 2010, TRENDS COGN SCI, V14, P441, DOI 10.1016/j.tics.2010.06.009
Dickens C., 1957, AM NOTES PICTURES IT
Donald M., 2006, LANG CULT MIND C 17
Gallagher S, 2012, PHENOMENOLOGICAL MIND, 2ND EDITION, P1
Gallagher S., 2005, BODY SHAPES MIND, DOI [10.1093/0199271941.001.0001, DOI 10.1093/0199271941.001.0001]
Gallagher S., 2007, NARRATIVE UNDERSTAND, P203, DOI [10.1017/S1358246107000100, DOI 10.1017/S1358246107000100]
Gallagher S, 2000, TRENDS COGN SCI, V4, P14, DOI 10.1016/S1364-6613(99)01417-5
Gallagher S, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00443
Gallagher S., 2012, REV PHILOS PSYCHOL, V3, P187, DOI [10.1007/s13164-011-0080-1, DOI 10.1007/S13164-011-0080-1]
Gallagher S, 2001, J CONSCIOUSNESS STUD, V8, P83
Gopnik Alison, 1997, WORDS THOUGHTS THEOR
GRANUCCI AF, 1969, CALIF LAW REV, V57, P839, DOI 10.2307/3479574
GRASSIAN S, 1983, AM J PSYCHIAT, V140, P1450
GUENTHER LISA, 2013, SOLITARY CONFINEMENT
Haney C, 2003, CRIME DELINQUENCY, V49, P124, DOI 10.1177/0011128702239239
Heidegger M., 1962, BEING TIME
Hobson P., 2004, CRADLE THOUGHT EXPLO
Howe M., 2000, FATE EARLY MEMORIES, DOI [10.1037/10369-000, DOI 10.1037/10369-000]
Husserl E., 1973, PHANOMENOLOGIE INT 1
Husserl E. Hua, 1959, 1 PHILOS 1923 4
Husserl Edmund, 1968, PHANOMENOLOGISCHE PS
Issartel J, 2007, NEUROSCI LETT, V411, P174, DOI 10.1016/j.neulet.2006.09.086
Jackson M., 2002, JUSTICE WALLS HUMAN
James W., 1890, PRINCIPLES PSYCHOL, V2, DOI [10.1037/10538-000, DOI 10.1037/10538-000]
Jaspers K., 1997, GEN PSYCHOPATHOLOGY, V2
Kendon A., 1990, CONDUCTING INTERACTI
Levin AR, 2014, J PEDIATR-US, V164, P123, DOI 10.1016/j.jpeds.2013.09.026
Lindblom J, 2008, EMERG COMMUN-STUD NE, V10, P49
MacReady N, 2009, LANCET, V373, P708
McDougal MS, 1980, HUMAN RIGHTS WORLD P
McTaggart J., 1908, MIND, V17, P457, DOI DOI 10.1093/MIND/XVII.4.457
MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
Merleau-Ponty M., 1967, STRUCTURE BEHAV
Merleau-Ponty M, 1962, PHENOMENOLOGY PERCEP
Minkowski Eugene, 1970, LIVED TIME PHENOMENO
Murray Lynne, 1985, SOCIAL PERCEPTION IN, P177
NEISSER ULRIC, 1988, PHILOS PSYCHOL, V1, P35, DOI DOI 10.1080/09515088808572924
Nelson Katherine, 2003, NARRATIVE CONSCIOUSN, P17
Noe A., 2004, ACTION PERCEPTION
Parker SW, 2005, CHILD DEV, V76, P54, DOI 10.1111/j.1467-8624.2005.00829.x
Pellegrino E. D., 2008, HUMAN DIGNITY BIOETH
RADIN MJ, 1978, U PENN LAW REV, V126, P989, DOI 10.2307/3311799
Ratcliffe M., 2006, RETHINKING COMMONSEN
Reddy V., 2008, INFANTS KNOW MINDS
Ricoeur Paul, 1992, ONESELF ANOTHER
Rochat P., 2001, INFANTS WORLD
Rutter M, 1999, J CHILD PSYCHOL PSYC, V40, P537, DOI 10.1017/S0021963099003935
Sass LA, 2003, SCHIZOPHRENIA BULL, V29, P427
Shalev S., 2009, SUPERMAX CONTROLLING
Smith PS, 2006, CRIME JUSTICE, V34, P441
Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
Torres Elizabeth B, 2013, Front Integr Neurosci, V7, P32, DOI 10.3389/fnint.2013.00032
Torres EB, 2013, NEUROCASE, V19, P150, DOI 10.1080/13554794.2011.654224
Trevarthen C., 1979, SPEECH BEGINNING INT, P321
Trevarthen C., 1978, ACTION GESTURE SYMBO, P183
TRONICK E, 1978, J AM ACAD CHILD PSY, V17, P1, DOI 10.1016/S0002-7138(09)62273-1
Varela F., 1991, EMBODIED MIND COGNIT
Varga S., 2012, PHILOS PSYCHIAT PSYC, V19, P103, DOI [10.1353/ppp.2012.0020, DOI 10.1353/PPP.2012.0020]
Wedekind J., 2011, SOLITARY WATCH FACT
Zahavi Dan, 2007, ROYAL I PHILOS S, V60, P179, DOI 10.1017/S1358246107000094
NR 68
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUN 12
PY 2014
VL 5
AR 585
DI 10.3389/fpsyg.2014.00585
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA AJ7TG
UT WOS:000337899500001
PM 24971072
ER
PT J
AU Jung, M
Kosaka, H
Saito, DN
Ishitobi, M
Morita, T
Inohara, K
Asano, M
Arai, S
Munesue, T
Tomoda, A
Wada, Y
Sadato, N
Okazawa, H
Iidaka, T
AF Jung, Minyoung
Kosaka, Hirotaka
Saito, Daisuke N.
Ishitobi, Makoto
Morita, Tomoyo
Inohara, Keisuke
Asano, Mizuki
Arai, Sumiyoshi
Munesue, Toshio
Tomoda, Akemi
Wada, Yuji
Sadato, Norihiro
Okazawa, Hidehiko
Iidaka, Tetsuya
TI Default mode network in young male adults with autism spectrum disorder:
relationship with autism spectrum traits
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder (ASD); Autism spectrum traits; Autism-spectrum
quotient (AQ); Default mode network (DMN); Resting-state functional
connectivities (rs-FCs); Anterior medial prefrontal cortex (aMPFC);
Posterior cingulate cortex (PCC)
ID FUNCTIONAL CONNECTIVITY MRI; COMMUNICATION DISORDERS; DIAGNOSTIC
INTERVIEW; ASPERGER-SYNDROME; SOCIAL COGNITION; HEAD MOTION; HUMAN
BRAIN; CORTEX; PSYCHOPATHOLOGY; ABNORMALITIES
AB Background: Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development (TD). Social cognition properties that are deeply associated with autism spectrum traits have been linked to functional connectivity between regions within the brain's default mode network (DMN). Previous studies have shown that the resting-state functional connectivities (rs-FCs) of DMN are low and show negative correlation with the level of autism spectrum traits in individuals with autism spectrum disorder (ASD). However, it is unclear whether individual differences of autism spectrum traits are associated with the strength of rs-FCs of DMN in participants including the general population.
Methods: Using the seed-based approach, we investigated the rs-FCs of DMN, particularly including the following two core regions of DMN: the anterior medial prefrontal cortex (aMPFC) and posterior cingulate cortex (PCC) in 19 young male adults with high-functioning ASD (mean age = 25.3 +/- 6.9 years; autism-spectrum quotient (AQ) = 33.4 +/- 4.2; full scale IQ (F-IQ) = 109.7 +/- 12.4) compared with 21 age- and IQ-matched young male adults from the TD group (mean age = 24.8 +/- 4.3 years; AQ = 18.6 +/- 5.7; F-IQ = 109.5 +/- 8.7). We also analyzed the correlation between the strength of rs-FCs and autism spectrum traits measured using AQ score.
Results: The strengths of rs-FCs from core regions of DMN were significantly lower in ASD participants than TD participants. Under multiple regression analysis, the strengths of rs-FCs in brain areas from aMPFC seed showed negative correlation with AQ scores in ASD participants and TD participants.
Conclusions: Our findings suggest that the strength of rs-FCs in DMN is associated with autism spectrum traits in the TD population as well as patients with ASD, supporting the continuum view. The rs-FCs of DMN may be useful biomarkers for the objective identification of autism spectrum traits, regardless of ASD diagnosis.
C1 [Jung, Minyoung; Kosaka, Hirotaka; Arai, Sumiyoshi; Munesue, Toshio; Tomoda, Akemi] Chiba Univ, Hamamatsu Univ, Kanazawa Univ,Osaka Univ,Div Dev Higher Brain Fun, Sch Med,United Grad Sch Child Dev,Dept Child Dev, Fukui, Eiheiji 9101193, Japan.
[Jung, Minyoung; Kosaka, Hirotaka; Arai, Sumiyoshi; Munesue, Toshio; Tomoda, Akemi] Univ Fukui, Fukui, Eiheiji 9101193, Japan.
[Kosaka, Hirotaka; Saito, Daisuke N.; Asano, Mizuki; Tomoda, Akemi; Wada, Yuji; Okazawa, Hidehiko] Univ Fukui, Res Ctr Child Mental Dev, Fukui, Eiheiji 9101193, Japan.
[Kosaka, Hirotaka; Ishitobi, Makoto; Inohara, Keisuke; Asano, Mizuki; Wada, Yuji] Univ Fukui, Fac Med Sci, Dept Neuropsychiat, Fukui, Eiheiji 9101193, Japan.
[Kosaka, Hirotaka; Saito, Daisuke N.; Sadato, Norihiro; Okazawa, Hidehiko] Univ Fukui, Biomed Imaging Res Ctr, Fukui, Eiheiji 9101193, Japan.
[Ishitobi, Makoto] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Child & Adolescent Mental Hlth, Kodaira, Tokyo 1878553, Japan.
[Morita, Tomoyo] Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan.
[Munesue, Toshio] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208641, Japan.
[Sadato, Norihiro] Natl Inst Physiol Sci, Dept Cerebral Res, Okazaki, Aichi 4448585, Japan.
[Iidaka, Tetsuya] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi 4668550, Japan.
RP Kosaka, H (reprint author), Chiba Univ, Hamamatsu Univ, Kanazawa Univ,Osaka Univ,Div Dev Higher Brain Fun, Sch Med,United Grad Sch Child Dev,Dept Child Dev, Fukui, Eiheiji 9101193, Japan.
EM hirotaka@u-fukui.ac.jp
FU Japan Society for the Promotion of Science [21220005, 21591509,
21791120, 25293248]; Japan Research Foundation for Clinical
Pharmacology; Takeda Science Foundation
FX We would like to express our sincere appreciation to the participants
and their families, who generously and courageously participated in this
research. This research was funded in part by Grants-in-Aid for
Scientific Research from the Japan Society for the Promotion of Science
(21220005, 21591509, 21791120, 25293248), the Japan Research Foundation
for Clinical Pharmacology, and the Takeda Science Foundation. Part of
this research was the result of 'Development of biomarker candidates for
social behavior' and 'Integrated research on neuropsychiatric disorders'
performed under the Strategic Research Program for Brain Sciences by the
MEXT of Japan.
CR Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
Andrews-Hanna JR, 2010, NEURON, V65, P550, DOI 10.1016/j.neuron.2010.02.005
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Association AP, 2000, DIAGN STAT MAN MENT, Vfourth
Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Baron-Cohen Simon, 1997, MINDBLINDNESS ESSAY
BISWAL B, 1995, MAGNET RESON MED, V34, P537, DOI 10.1002/mrm.1910340409
Bolte S, 2011, J AUTISM DEV DISORD, V41, P66, DOI 10.1007/s10803-010-1024-9
Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
Buckner RL, 2009, J NEUROSCI, V29, P1860, DOI 10.1523/JNEUROSCI.5062-08.2009
Chao-Gan Y, 2010, FRONT SYST NEUROSCI, V4, P1, DOI 10.3389/neuro.06.001.2010
Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
Deen Ben, 2012, Nature, V491, pS20
Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
Frith U, 1991, AUTISM ASPERGER SYND
Gilbert SJ, 2007, SOC COGN AFFECT NEUR, V2, P217, DOI 10.1093/scan/nsm014
Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
Hagmann P, 2008, PLOS BIOL, V6, P1479, DOI 10.1371/journal.pbio.0060159
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
Ishitobi M, 2011, RES AUTISM SPECT DIS, V5, P910, DOI 10.1016/j.rasd.2010.10.005
Joel SE, 2011, MAGN RESON MED, V66, P644, DOI 10.1002/mrm.22818
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
Kennedy DP, 2008, SOC COGN AFFECT NEUR, V3, P177, DOI 10.1093/scan/nsn011
Komeda H, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-20
Kosaka H, 2010, NEUROIMAGE, V50, P1357, DOI 10.1016/j.neuroimage.2010.01.085
Lai MC, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001544
Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
Lowe MJ, 1998, NEUROIMAGE, V7, P119, DOI 10.1006/nimg.1997.0315
Lynch CJ, 2013, BIOL PSYCHIAT, V74, P212, DOI 10.1016/j.biopsych.2012.12.013
Menon V, 2011, TRENDS COGN SCI, V15, P483, DOI 10.1016/j.tics.2011.08.003
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Morita T, 2012, SOC NEUROSCI-UK, V7, P223, DOI 10.1080/17470919.2011.598945
Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
Murphy K, 2009, NEUROIMAGE, V44, P893, DOI 10.1016/j.neuroimage.2008.09.036
Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
Raichle Marcus E, 2007, Neuroimage, V37, P1083, DOI 10.1016/j.neuroimage.2007.02.041
Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
Satterthwaite TD, 2012, NEUROIMAGE, V60, P623, DOI 10.1016/j.neuroimage.2011.12.063
Satterthwaite TD, 2013, NEUROIMAGE, V64, P240, DOI 10.1016/j.neuroimage.2012.08.052
Schilbach L, 2008, CONSCIOUS COGN, V17, P457, DOI 10.1016/j.concog.2008.03.013
Skuse DH, 2009, J AM ACAD CHILD PSY, V48, P128, DOI 10.1097/CHI.0b013e31819176b8
Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
von dem Hagen EAH, 2013, SOC COGN AFFECT NEUR, V8, P694, DOI 10.1093/scan/nss053
Wechsler D., 1997, WAIS 3 WECHSLER ADUL
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 53
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUN 11
PY 2014
VL 5
AR 35
DI 10.1186/2040-2392-5-35
PG 11
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AK8HV
UT WOS:000338669400001
PM 24955232
ER
PT J
AU Mottolese, R
Redoute, J
Costes, N
Le Bars, D
Sirigu, A
AF Mottolese, Raphaelle
Redoute, Jerome
Costes, Nicolas
Le Bars, Didier
Sirigu, Angela
TI Switching brain serotonin with oxytocin
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID POSITRON-EMISSION-TOMOGRAPHY; TIME-OF-FLIGHT; RECEPTOR-BINDING; PLASMA
OXYTOCIN; AMYGDALA REACTIVITY; 5-HT1A RECEPTORS; SOCIAL COGNITION;
NEURAL CIRCUITRY; TEMPORAL-LOBE; F-18-MPPF PET
AB Serotonin (5-HT) and oxytocin (OXT) are two neuromodulators involved in human affect and sociality and in disorders like depression and autism. We asked whether these chemical messengers interact in the regulation of emotion-based behavior by administering OXT or placebo to 24 healthy subjects and mapping cerebral 5-HT system by using 2'-methoxyphenyl-(N-2'-pyridinyl)-p-[F-18]fluoro-benzamidoethylpiperazine ([F-18]MPPF), an antagonist of 5-HT1A receptors. OXT increased [F-18]MPPF nondisplaceable binding potential (BPND) in the dorsal raphe nucleus (DRN), the core area of 5-HT synthesis, and in the amygdala/hippocampal complex, insula, and orbitofrontal cortex. Importantly, the amygdala appears central in the regulation of 5-HT by OXT: [F-18]MPPF BPND changes in the DRN correlated with changes in right amygdala, which were in turn correlated with changes in hippocampus, insula, subgenual, and orbitofrontal cortex, a circuit implicated in the control of stress, mood, and social behaviors. OXT administration is known to inhibit amygdala activity and results in a decrease of anxiety, whereas high amygdala activity and 5-HT dysregulation have been associated with increased anxiety. The present study reveals a previously unidentified form of interaction between these two systems in the human brain, i.e., the role of OXT in the inhibitory regulation of 5-HT signaling, which could lead to novel therapeutic strategies for mental disorders.
C1 [Mottolese, Raphaelle; Sirigu, Angela] CNRS, Unite Mixte Rech 5229, Ctr Cognit Neurosci, F-69675 Bron, France.
[Mottolese, Raphaelle; Redoute, Jerome; Le Bars, Didier; Sirigu, Angela] Univ Lyon 1, F-69609 Lyon, France.
[Redoute, Jerome; Costes, Nicolas; Le Bars, Didier] Ctr Etud & Rech Multimodal & Pluridisciplinaire I, F-69003 Lyon, France.
RP Sirigu, A (reprint author), CNRS, Unite Mixte Rech 5229, Ctr Cognit Neurosci, F-69675 Bron, France.
EM sirigu@isc.cnrs.fr
FU Region Rhone-Alpes; Centre National de la Recherche Scientifique;
Fondation de France; Labex Cortex; French Ministry of Research
fellowship
FX We thank Region Rhone-Alpes for supporting Centre d'Etude et de
Recherche Multimodal et Pluridisciplinaire PET/CT scanner acquisition,
A. Lefevre for help in testing subjects, Rolf Heckemann for performing
MRI segmentation, M. Desmurget and J.-R. Duhamel for helpful
suggestions, S. Thobois for clinical support during the project ethical
approval, and C. Billotey for performing subjects' clinical
examinations. This research was funded by Centre National de la
Recherche Scientifique (A. S.), Fondation de France (A. S.), Labex
Cortex (A. S.), Region Rhone-Alpes (A. S.), and a French Ministry of
Research fellowship (to R.M.).
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
ARLETTI R, 1987, LIFE SCI, V41, P1725, DOI 10.1016/0024-3205(87)90600-X
Aznavour N, 2007, NEUROPHARMACOLOGY, V52, P695, DOI 10.1016/j.neuropharm.2006.09.023
Barnes NM, 1999, NEUROPHARMACOLOGY, V38, P1083, DOI 10.1016/S0028-3908(99)00010-6
Bartz JA, 2006, HORM BEHAV, V50, P518, DOI 10.1016/j.yhbeh.2006.06.018
Brett M, 2002, NEUROIMAGE, V16, P1140
Cools R, 2008, TRENDS COGN SCI, V12, P31, DOI 10.1016/j.tics.2007.10.01
Costes N, 2007, J NUCL MED, V48, P1279, DOI 10.2967/jnumed.107.041905
Costes N, 2002, J CEREBR BLOOD F MET, V22, P753
DAVIS M, 1992, ANNU REV NEUROSCI, V15, P353, DOI 10.1146/annurev.ne.15.030192.002033
De Haes JIU, 2002, SYNAPSE, V46, P108, DOI 10.1002/syn.10134
Didelot A, 2010, J NUCL MED, V51, P1732, DOI 10.2967/jnumed.109.070938
Drevets WC, 1997, NATURE, V386, P824, DOI 10.1038/386824a0
Drevets WC, 2007, NUCL MED BIOL, V34, P865, DOI 10.1016/j.nuemedbio.2007.06.008
Eaton JL, 2012, DEV PSYCHOBIOL, V54, P92, DOI 10.1002/dev.20566
Emiliano ABF, 2007, NEUROPSYCHOPHARMACOL, V32, P977, DOI 10.1038/sj.npp.1301206
Fisher PM, 2006, NAT NEUROSCI, V9, P1362, DOI 10.1038/nn1780
Freedman LJ, 2000, J COMP NEUROL, V421, P172
Frey BN, 2008, NEUROIMAGE, V42, P850, DOI 10.1016/j.neuroimage.2008.05.009
Friston KJ, 1994, HUMAN BRAIN MAPPING, V2, P189, DOI DOI 10.1002/HBM.460020402
Gousias IS, 2008, NEUROIMAGE, V40, P672, DOI 10.1016/j.neuroimage.2007.11.034
GOZLAN H, 1995, EUR J PHARM-MOLEC PH, V288, P173, DOI 10.1016/0922-4106(95)90192-2
Gross C, 2002, NATURE, V416, P396, DOI 10.1038/416396a
Gunn RN, 1998, NEUROIMAGE, V8, P426, DOI 10.1006/nimg.1998.0379
Hahn A, 2009, EUR NEUROPSYCHOPHARM, V19, pS182
Hammers A, 2003, HUM BRAIN MAPP, V19, P224, DOI 10.1002/hbm.10123
Heckemann RA, 2010, NEUROIMAGE, V51, P221, DOI 10.1016/j.neuroimage.2010.01.072
Hornung JP, 2003, J CHEM NEUROANAT, V26, P331, DOI 10.1016/j.jchemneu.2003.10.002
Jakoby BW, 2011, PHYS MED BIOL, V56, P2375, DOI 10.1088/0031-9155/56/8/004
Jorgensen H, 2003, J NEUROENDOCRINOL, V15, P242, DOI 10.1046/j.1365-2826.2003.00978.x
KAWAHARA H, 1993, NEUROSCI LETT, V162, P81, DOI 10.1016/0304-3940(93)90565-3
Kim S, 2014, BRAIN RES, V1580, P219, DOI 10.1016/j.brainres.2013.11.009
Kirsch P, 2005, J NEUROSCI, V25, P11489, DOI 10.1523/JNEUROSCI.3984-05.2005
Knobloch HS, 2012, NEURON, V73, P553, DOI 10.1016/j.neuron.2011.11.030
Lanzenberger RR, 2007, BIOL PSYCHIAT, V61, P1081, DOI 10.1016/j.biopsych.2006.05.022
Le Bars D, 1998, NUCL MED BIOL, V25, P343, DOI 10.1016/S0969-8051(97)00229-1
Lee R, 2003, PSYCHIAT RES, V118, P129, DOI 10.1016/S0165-1781(03)00070-2
Lischke A, 2012, PSYCHONEUROENDOCRINO, V37, P1431, DOI 10.1016/j.psyneuen.2012.01.011
Lucki I, 1998, BIOL PSYCHIAT, V44, P151, DOI 10.1016/S0006-3223(98)00139-5
MA QP, 1991, NEUROSCI LETT, V134, P21, DOI 10.1016/0304-3940(91)90499-J
Marti-Climent JM, 2013, REV ESP MED NUCL IMA, V32, P13, DOI 10.1016/j.remn.2012.07.001
Mayberg HS, 2005, NEURON, V45, P651, DOI 10.1016/j.neuron.2005.02.014
McCarthy MM, 1996, PHYSIOL BEHAV, V60, P1209
Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
Monk CS, 2008, DEV PSYCHOPATHOL, V20, P1231, DOI 10.1017/S095457940800059X
Parks CL, 1998, P NATL ACAD SCI USA, V95, P10734, DOI 10.1073/pnas.95.18.10734
Riem MME, 2011, BIOL PSYCHIAT, V70, P291, DOI 10.1016/j.biopsych.2011.02.006
Roberts AC, 2011, BIOL PSYCHIAT, V69, P1185, DOI 10.1016/j.biopsych.2010.12.037
SAWCHENKO PE, 1983, BRAIN RES, V277, P355, DOI 10.1016/0006-8993(83)90945-9
Sibon I, 2008, BIOL PSYCHIAT, V63, P1135, DOI 10.1016/j.biopsych.2007.11.016
Tops M, 2007, PSYCHOPHYSIOLOGY, V44, P444, DOI 10.1111/j.1469-8986.2007.00510.x
Uvnas-Moberg K, 1998, NEWS PHYSIOL SCI, V13, P22
Whitaker-Azmitia PM, 2005, INT J DEV NEUROSCI, V23, P75, DOI 10.1016/j.ijdevneu.2004.07.022
Yoshida M, 2009, J NEUROSCI, V29, P2259, DOI 10.1523/JNEUROSCI.5593-08.2009
Zafeiriou DI, 2009, CURR NEUROPHARMACOL, V7, P150, DOI 10.2174/157015909788848848
Zimmer L, 2003, J NUCL MED, V44, P1495
NR 57
TC 5
Z9 5
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 10
PY 2014
VL 111
IS 23
BP 8637
EP 8642
DI 10.1073/pnas.1319810111
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AI6IJ
UT WOS:000336976000079
PM 24912179
ER
PT J
AU aan het Rot, M
Hogenelst, K
AF aan het Rot, Marije
Hogenelst, Koen
TI The Influence of Affective Empathy and Autism Spectrum Traits on
Empathic Accuracy
SO PLOS ONE
LA English
DT Article
ID EMOTIONAL FACIAL EXPRESSIONS; HIGH-FUNCTIONING ADULTS;
ASPERGER-SYNDROME; QUOTIENT AQ; DISORDER; CHILDREN; FACETS; ALEXITHYMIA;
COGNITION; OXYTOCIN
AB Autism spectrum disorder is characterized by interpersonal deficits and has been associated with limited cognitive empathy, which includes perspective taking, theory of mind, and empathic accuracy (EA). The capacity for affective empathy may also be impaired. In the present study we aimed to determine if EA in normally developing individuals with varying levels of autism spectrum traits is moderated by trait affective empathy. Fifty male and fifty female participants ('perceivers') completed the Autism-Spectrum Quotient and the Balanced Emotional Empathy Scale to assess autism spectrum traits and trait affective empathy, respectively. EA was assessed using a Dutch-language version of a previously developed task and involved rating the feelings of others ('targets') verbally recounting autobiographical emotional events. Targets varied in trait emotional expressivity, assessed using the Berkeley Expressivity Questionnaire. Perceivers with more autism spectrum traits performed worse on the EA task, particularly when their trait affective empathy was relatively low. Interpersonal deficits in autism spectrum disorder may be partially explained by low cognitive empathy. Further, they might be aggravated by a limited capacity for affective empathy.
C1 [aan het Rot, Marije] Univ Groningen, Dept Psychol, NL-9712 TS Groningen, Netherlands.
Univ Groningen, Sch Behav & Cognit Neurosci, Groningen, Netherlands.
RP aan het Rot, M (reprint author), Univ Groningen, Dept Psychol, Grote Kruisstr 2-1, NL-9712 TS Groningen, Netherlands.
EM m.aan.het.rot@rug.nl
FU Innovational Research Incentives Scheme Veni from the Netherlands
Organisation for Scientific Research (NWO, Veni) [451-09-013]
FX The work was supported by the Innovational Research Incentives Scheme
Veni from the Netherlands Organisation for Scientific Research (NWO,
Veni grant 451-09-013 awarded to Dr. aan het Rot). The funder had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Aiken L, 1991, MULTIPLE REGRESSION
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Bartz JA, 2010, PSYCHOL SCI, V21, P1426, DOI 10.1177/0956797610383439
Batson C. D., 2009, HDB IMAGINATION MENT, P267
Bellebaum C, 2014, COGN NEUROPSYCHIATRY, V19, P205, DOI 10.1080/13546805.2013.823860
Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
Bons D, 2013, J ABNORM CHILD PSYCH, V41, P425, DOI 10.1007/s10802-012-9689-5
Cook R, 2013, PSYCHOL SCI, V24, P723, DOI 10.1177/0956797612463582
Courtright KE, 2005, J CRIMINAL JUSTICE E, V16, P125, DOI 10.1080/1051125042000333514
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Decety J, 2010, DEV NEUROSCI-BASEL, V32, P257, DOI 10.1159/000317771
Demurie E, 2011, RES AUTISM SPECT DIS, V5, P126, DOI 10.1016/j.rasd.2010.03.002
Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
Gadassi R, 2011, PSYCHOL SCI, V22, P1033, DOI 10.1177/0956797611414728
Groen Y, 2013, NEUROPSYCHOLOGIA, V51, P142, DOI 10.1016/j.neuropsychologia.2012.11.012
Gross JJ, 1997, J PERS SOC PSYCHOL, V72, P435, DOI 10.1037/0022-3514.72.2.435
GROSS JJ, 1995, PERS INDIV DIFFER, V19, P555, DOI 10.1016/0191-8869(95)00055-B
Hadjikhani N, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2013.113
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Ickes W., 1997, EMPATHIC ACCURACY
KASARI C, 1990, J AUTISM DEV DISORD, V20, P87, DOI 10.1007/BF02206859
Leiberg S, 2006, PROG BRAIN RES, V156, P419, DOI 10.1016/S0079-6123(06)56023-6
Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
Mathersul D, 2013, J CLIN EXP NEUROPSYC, V35, P655, DOI 10.1080/13803395.2013.809700
Mathersul D, 2013, INT J PSYCHOPHYSIOL, V89, P475, DOI 10.1016/j.ijpsycho.2013.04.014
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
Mehrabian A, 1997, AGGRESSIVE BEHAV, V23, P433, DOI 10.1002/(SICI)1098-2337(1997)23:6<433::AID-AB3>3.0.CO;2-H
Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006
Newton BW, 2008, ACAD MED, V83, P244, DOI 10.1097/ACM.0b013e3181637837
Roeyers H, 2010, EUR J DEV PSYCHOL, V7, P123, DOI 10.1080/17405620903425924
Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x
Shamay-Tsoory SG, 2002, NEUROCASE, V8, P245
Shamay-Tsoory Simone G, 2011, Neuroscientist, V17, P18, DOI 10.1177/1073858410379268
SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
Striepens N, 2011, FRONT NEUROENDOCRIN, V32, P426, DOI 10.1016/j.yfrne.2011.07.001
Swart M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005751
Theodoridou A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00197
YIRMIYA N, 1992, CHILD DEV, V63, P150, DOI 10.1111/j.1467-8624.1992.tb03603.x
Young KA, 2011, FRONT NEUROENDOCRIN, V32, P53, DOI 10.1016/j.yfrne.2010.07.006
Zaki J, 2008, PSYCHOL SCI, V19, P399, DOI 10.1111/j.1467-9280.2008.02099.x
NR 43
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 6
PY 2014
VL 9
IS 6
AR e98436
DI 10.1371/journal.pone.0098436
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AP1YS
UT WOS:000341869000029
PM 24905105
ER
PT J
AU Edgar, JC
Lanza, MR
Daina, AB
Monroe, JF
Khan, SY
Blaskey, L
Cannon, KM
Jenkins, J
Qasmieh, S
Levy, SE
Roberts, TPL
AF Edgar, J. Christopher
Lanza, Matthew R.
Daina, Aleksandra B.
Monroe, Justin F.
Khan, Sarah Y.
Blaskey, Lisa
Cannon, Katelyn M.
Jenkins, Julian, III
Qasmieh, Saba
Levy, Susan E.
Roberts, Timothy P. L.
TI Missing and delayed auditory responses in young and older children with
autism spectrum disorders
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorders; M50; M100; superior temporal gyrus;
magnetoencephalography
ID EVOKED MAGNETIC-FIELDS; SYSTEM ACTIVITY; HUMAN BRAIN; N1 WAVE;
POTENTIALS; MIDDLE; MATURATION; P50; MEG; EEG
AB Background:The development of left and right superior temporal gyrus (STG) 50 ms (M50) and 100 ms (M100) auditory responses in typically developing (TD) children and in children with autism spectrum disorder (ASD) was examined. Reflecting differential development of primary/secondary auditory areas and supporting previous studies, it was hypothesized that whereas left and right M50 STG responses would be observed equally often in younger and older children, left and right M100 STG responses would more often be absent in younger than older children. In ASD, delayed neurodevelopment would be indicated via the observation of a greater proportion of ASD than TD subjects showing missing M100 but not M50 responses in both age groups. Missing M100 responses would be observed primarily in children with ASD with language impairment (ASD + LI) (and perhaps concomitantly lower general cognitive abilities).
Methods: Thirty-five TD controls, 63 ASD without language impairment (ASD LI), and 38 ASD + LI were recruited. Binaural tones were presented. The presence or absence of a STG M50 and M100 was scored. Subjects were grouped into younger (6-10 years old) and older groups (11-15 years old).
Results: Although M50 responses were observed equally often in older and younger subjects and equally often in TD and ASD, left and right M50 responses were delayed in ASD LI and ASD + LI. Group comparisons showed that in younger subjects M100 responses were observed more often in TD than ASD + LI (90 versus 66%, p= 0.04), with no differences between TD and ASD LI (90 versus 76%, p= 0.14) or between ASD LI and ASD + LI (76 versus 66%, p= 0.53). In older subjects, whereas no differences were observed between TD and ASD + LI, responses were observed more often in ASD LI than ASD + LI. Findings were similar when splitting the ASD group into lower- and higher-cognitive functioning groups.
Conclusion: Although present in all groups, M50 responses were delayed in ASD. Examining the TD data, findings indicated that by 11 years, a right M100 should be observed in 100% of subjects and a left M100 in 80% of subjects. Thus, by 11 years, lack of a left and especially right M100 offers neurobiological insight into sensory processing that may underlie language or cognitive impairment.
C1 [Edgar, J. Christopher; Lanza, Matthew R.; Daina, Aleksandra B.; Monroe, Justin F.; Khan, Sarah Y.; Blaskey, Lisa; Cannon, Katelyn M.; Jenkins, Julian, III; Qasmieh, Saba; Roberts, Timothy P. L.] Childrens Hosp Philadelphia, Lurie Family Fdn MEG Imaging Ctr, Dept Radiol, Philadelphia, PA 19104 USA.
[Blaskey, Lisa; Qasmieh, Saba; Levy, Susan E.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
RP Edgar, JC (reprint author), Childrens Hosp Philadelphia, Dept Radiol, Wood Bldg,Suite 2115,34th & Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM edgarj@email.chop.edu
FU NIH [R01DC008871, R01DC008871-02S1, K08 MH085100]; Eunice Kennedy
Shriver National Institute of Child Health and Human Development of the
NIH [P30HD026979]; Nancy Lurie Marks Family Foundation (NLMFF);
Pennsylvania Department of Health; Autism Speaks; Oberkircher Family
FX This study was supported in part by NIH grant R01DC008871 (Timothy P. L.
Roberts), NIH grant R01DC008871-02S1, a NIH grant K08 MH085100 (J.
Christopher Edgar), Award number P30HD026979 from the Eunice Kennedy
Shriver National Institute of Child Health and Human Development of the
NIH, and grants from the Nancy Lurie Marks Family Foundation (NLMFF) and
Autism Speaks. This research has been funded (in part) by a grant from
the Pennsylvania Department of Health. The Pennsylvania Department of
Health specifically disclaims responsibility for any analyses,
interpretations, or conclusions. Dr. Roberts gratefully acknowledges the
Oberkircher Family for the Oberkircher Family Chair in Pediatric
Radiology at CHOP.
CR BERG P, 1994, ELECTROEN CLIN NEURO, V90, P229, DOI 10.1016/0013-4694(94)90094-9
Brinkman MJR, 2007, CLIN NEUROPHYSIOL, V118, P1517, DOI 10.1016/j.clinph.2007.04.002
Bruneau N, 1997, PSYCHOPHYSIOLOGY, V34, P32, DOI 10.1111/j.1469-8986.1997.tb02413.x
CHATRIAN GE, 1960, ELECTROEN CLIN NEURO, V12, P479, DOI 10.1016/0013-4694(60)90024-9
COHEN MM, 1982, ELECTROEN CLIN NEURO, V53, P231, DOI 10.1016/0013-4694(82)90028-1
Cornew L, 2012, J AUTISM DEV DISORD, V42, P1884, DOI 10.1007/s10803-011-1431-6
Edgar JC, 2015, J AUTISM DEV DISORD, V45, P395, DOI 10.1007/s10803-013-1904-x
Edgar JC, 2003, BIOL PSYCHOL, V65, P1, DOI 10.1016/S0301-0511(03)00094-2
ERWIN R, 1986, ELECTROEN CLIN NEURO, V65, P383, DOI 10.1016/0168-5597(86)90017-1
ERWIN RJ, 1986, ELECTROEN CLIN NEURO, V64, P417, DOI 10.1016/0013-4694(86)90075-1
Freedman R, 1996, ARCH GEN PSYCHIAT, V53, P1114
FREEDMAN R, 1987, PSYCHOPHYSIOLOGY, V24, P223, DOI 10.1111/j.1469-8986.1987.tb00282.x
Goff W. R., 1978, EVOKED ELECT ACTIVIT, P505
Grunwald T, 2003, BIOL PSYCHIAT, V53, P511, DOI 10.1016/S0002-3223(03)01673-2
Hari R, 1990, ADV AUDIOL, V6, P222
Huang MX, 2003, CLIN NEUROPHYSIOL, V114, P835, DOI 10.1016/S1388-2457(03)00041-5
Huotilainen M, 1998, EVOKED POTENTIAL, V108, P370, DOI 10.1016/S0168-5597(98)00017-3
Kanno A, 2000, NEUROSCI LETT, V293, P187, DOI 10.1016/S0304-3940(00)01525-1
Khan SY, 2010, IFMBE PROC, V28, P401
Kral A, 2007, BRAIN RES REV, V56, P259, DOI 10.1016/j.brainresrev.2007.07.021
KRAUS N, 1992, BRAIN RES, V587, P186, DOI 10.1016/0006-8993(92)90996-M
LEE YS, 1984, BRAIN, V107, P115, DOI 10.1093/brain/107.1.115
Ligeois-Chauvel C., 1994, ELECTROENCEPHALOGR C, V92, P414
Lutkenhoner B, 1998, AUDIOL NEURO-OTOL, V3, P191, DOI 10.1159/000013790
MAKELA JP, 1994, ELECTROEN CLIN NEURO, V92, P414, DOI 10.1016/0168-5597(94)90018-3
Marshall PJ, 2004, INT J PSYCHOPHYSIOL, V51, P135, DOI 10.1016/j.ijpsycho.2003.08.004
McNemar Q, 1947, PSYCHOMETRIKA, V12, P153, DOI 10.1007/BF02295996
Moore JK, 2007, INT J AUDIOL, V46, P460, DOI 10.1080/14992020701383019
Moore JK, 2001, JARO, V2, P297, DOI 10.1007/s101620010052
MylesWorsley M, 1996, BIOL PSYCHIAT, V39, P289, DOI 10.1016/0006-3223(95)00134-4
NAATANEN R, 1987, PSYCHOPHYSIOLOGY, V24, P375, DOI 10.1111/j.1469-8986.1987.tb00311.x
Ninomiya H, 1997, EVOKED POTENTIAL, V104, P23, DOI 10.1016/S0168-5597(96)96026-8
Oranje B, 2013, PSYCHIAT RES, V206, P287, DOI 10.1016/j.psychres.2012.10.014
Orekhova EV, 2008, NEUROSCI LETT, V434, P218, DOI 10.1016/j.neulet.2008.01.066
Orekhova EV, 2009, CLIN NEUROPHYSIOL, V120, P520, DOI 10.1016/j.clinph.2008.12.034
Orekhova EV, 2013, BRAIN TOPOGR, V26, P410, DOI 10.1007/s10548-012-0262-x
PAETAU R, 1995, J CLIN NEUROPHYSIOL, V12, P177, DOI 10.1097/00004691-199503000-00008
PELIZZONE M, 1987, NEUROSCI LETT, V82, P303, DOI 10.1016/0304-3940(87)90273-4
Picton TW, 1999, AUDIOL NEURO-OTOL, V4, P64, DOI 10.1159/000013823
Ponton C, 2002, CLIN NEUROPHYSIOL, V113, P407, DOI 10.1016/S1388-2457(01)00733-7
Ponton C W, 1999, Scand Audiol Suppl, V51, P13
Ponton CW, 2000, CLIN NEUROPHYSIOL, V111, P220, DOI 10.1016/S1388-2457(99)00236-9
Ponton CW, 2001, AUDIOL NEURO-OTOL, V6, P363, DOI 10.1159/000046846
Rasco L, 2000, Sleep Res Online, V3, P97
REITE M, 1988, ELECTROEN CLIN NEURO, V70, P490, DOI 10.1016/0013-4694(88)90147-2
Ceponiene R, 2002, CLIN NEUROPHYSIOL, V113, P870, DOI 10.1016/S1388-2457(02)00078-0
Roberts TPL, 2014, FRONT HUM NEUROSCI, V8, DOI 10.3389/fnhum.2014.00099
Roberts TPL, 2013, BRAIN RES, V1537, P79, DOI 10.1016/j.brainres.2013.09.011
Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
Roberts TPL, 2009, NEUROREPORT, V20, P1586, DOI 10.1097/WNR.0b013e3283306854
Rojas DC, 1998, NEUROREPORT, V9, P1543
SATTERFIELD JH, 1984, BIOL PSYCHIAT, V19, P973
Scherg M, 1996, Electroencephalogr Clin Neurophysiol Suppl, V46, P127
Stroganova TA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069100
Sussman E, 2008, HEARING RES, V236, P61, DOI 10.1016/j.heares.2007.12.001
TonnquistUhlen I, 1996, EAR HEARING, V17, P314, DOI 10.1097/00003446-199608000-00003
WALDO MC, 1994, SCHIZOPHR RES, V12, P93, DOI 10.1016/0920-9964(94)90067-1
Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002
Wunderlich JL, 2006, HEARING RES, V212, P212, DOI 10.1016/j.heares.2005.11.008
Yoshimura Y, 2012, EUR J NEUROSCI, V35, P644, DOI 10.1111/j.1460-9568.2012.07998.x
Yoshiura T, 1995, BRAIN RES, V703, P139, DOI 10.1016/0006-8993(95)01075-0
Yvert B, 2001, CEREB CORTEX, V11, P411, DOI 10.1093/cercor/11.5.411
NR 62
TC 1
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JUN 6
PY 2014
VL 8
AR 417
DI 10.3389/fnhum.2014.00417
PG 13
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AM1LF
UT WOS:000339606700001
PM 24936181
ER
PT J
AU Fuchs, T
Koch, SC
AF Fuchs, Thomas
Koch, Sabine C.
TI Embodied affectivity: on moving and being moved
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE embodiment; affect; emotion; body feedback; embodied intersubjectivity;
interaffectivity; psychopathology; embodied therapies
ID RANDOMIZED CONTROLLED-TRIAL; AUTISM; DEPRESSION; ALEXITHYMIA;
HYPOTHESIS; SOMATOFORM; DISORDERS; IMITATION; COGNITION; MOVEMENT
AB There is a growing body of research indicating that bodily sensation and behavior strongly influences one's emotional reaction toward certain situations or objects. On this background, a framework model of embodied affectivity(1) is suggested: we regard emotions as resulting from the circular interaction between affective qualities or affordances in the environment and the subject's bodily resonance, be it in the form of sensations, postures, expressive movements or movement tendencies. Motion and emotion are thus intrinsically connected: one is moved by movement (perception; impression; affection(2)) and moved to move (action; expression; e-motion). Through its resonance, the body functions as a medium of emotional perception: it colors or charges self-experience and the environment with affective valences while it remains itself in the background of one's own awareness. This model is then applied to emotional social understanding or interaffectivity which is regarded as an intertwinement of two cycles of embodied affectivity, thus continuously modifying each partner's affective affordances and bodily resonance. We conclude with considerations of how embodied affectivity is altered in psychopathology and can be addressed in psychotherapy of the embodied self.
C1 [Fuchs, Thomas] Univ Clin Heidelberg, Heidelberg, Germany.
[Koch, Sabine C.] SRH Univ Heidelberg, Dept Therapeut Sci, D-69123 Heidelberg, Germany.
RP Koch, SC (reprint author), SRH Univ Heidelberg, Movement Therapy Dept, Maria Probst Str 3, D-69123 Heidelberg, Germany.
EM sabine.koch@hochschule-heidelberg.de
CR Bargh JA, 2012, EMOTION, V12, P154, DOI 10.1037/a0023527
Boettinger B., 2012, THESIS HEIDELBERG
Bourdieu Pierre, 1990, LOGIC PRACTICE, P52
CACIOPPO JT, 1993, J PERS SOC PSYCHOL, V65, P5, DOI 10.1037//0022-3514.65.1.5
Caldwell C, 2012, ADV CONSC RES, V84, P255
Condon W. S., 1979, SPEECH, P131
Cuddy A. J. C., 2012, HARVARD BUSINESS SCH
Damasio A., 1994, DESCARTES ERROR
Damasio AR, 1996, PHILOS T R SOC B, V351, P1413, DOI 10.1098/rstb.1996.0125
Darwin C, 1872, EXPRESSION EMOTIONS
De Jaegher Hanne, 2013, Front Integr Neurosci, V7, P15, DOI 10.3389/fnint.2013.00015
de Rivera J, 1977, STRUCTURAL THEORY EM
De Sousa R., 2010, EMOTION
Downing G., 2000, HEIDEGGER COPING COG, V2, P254
Duddu V, 2003, J PSYCHOSOM RES, V54, P435, DOI 10.1016/S0022-3999(02)00440-3
Duncan RP, 2012, NEUROREHAB NEURAL RE, V26, P132, DOI 10.1177/1545968311421614
Ekman P., 1972, EMOTION HUMAN FACE
Fischman D., 2008, LIFE IS DANCE ART SC, P33
Frijda N. H., 1994, NATURE EMOTION FUNDA, P59
Frijda N. H., 1986, EMOTIONS
Froese T, 2012, PHENOMENOL COGN SCI, V11, P205, DOI 10.1007/s11097-012-9254-2
Fuchs M., 1997, FUNKTIONELLE ENTSPAN
Fuchs T., 2005, PHILOS PSYCHIAT PSYC, V12, P95, DOI [10.1353/ppp.2005.0040, DOI 10.1353/PPP.2005.0040]
Fuchs T, 2013, J CONSCIOUSNESS STUD, V20, P219
Fuchs T, 2009, PHENOMENOL COGN SCI, V8, P465, DOI 10.1007/s11097-009-9136-4
Fuchs T., 2007, AM J PSYCHOTHER, V61, P432
Fuchs T, 2012, ADV CONSC RES, V84, P9
Fulford B., 2013, OXFORD HDB PHILOS PS
Fustos J, 2013, SOC COGN AFFECT NEUR, V8, P911, DOI 10.1093/scan/nss089
Gallagher S., 2004, PHILOS PSYCHIAT PSYC, V11, P199, DOI [10.1353/ppp.2004.0063, DOI 10.1353/PPP.2004.0063]
Gendlin E. T., 1967, GOALS PSYCHOTHERAPY, P180
Gibson J. J., 1979, ECOLOGICAL APPROACH
Goldie Peter, 2000, EMOTIONS PHILOS EXPL
Gordon Robert, 1987, STRUCTURE EMOTIONS
Graerne J. T., 2000, HDB EMOTIONAL INTELL, P40
Grandin T., 1995, THINKING PICTURES OT
Hatfield Elaine, 1994, EMOTIONAL CONTAGION
Havas M., 2010, PSYCHOL SCI, V21, P95, DOI [10.1177/0956797610374742, DOI 10.1177/0956797610374742]
Hesse C, 2008, J SOC PERS RELAT, V25, P793, DOI 10.1177/0265407508096696
Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481
Husserl E., 1952, IDEEN REINEN PHANOME, VIV
James W., 1984, MIND, V19, P188, DOI DOI 10.1093/MIND/OS-IX.34.188
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Kafka G, 1950, ACTA PSYCHOL, V7, P256, DOI 10.1016/0001-6918(50)90018-7
Kestenberg J., 1975, PARENTS CHILDREN
Kestenberg J. S., 1973, ROLE MOVEMENT PATTER, V1
Kestenberg J. S., 1979, ROLE MOVEMENT PATTER, VII
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Koch S, 2014, ART PSYCHOTHER, V41, P46, DOI 10.1016/j.aip.2013.10.004
Koch S. C., 2011, AM J DANCE THER, V33, P57, DOI [10.1007/sl0465-011-9108-4, DOI 10.1007/S10465-011-9108-4]
Koch S. C., 2014, RHYTHM IS IT EFFECTS
Koch S. C., 2014, AUTISM
Koch SC, 2011, SOC PSYCHOL-GERMANY, V42, P214, DOI 10.1027/1864-9335/a000065
Koch SC, 2007, ART PSYCHOTHER, V34, P340, DOI 10.1016/j.aip.2007.07.001
Koch SC, 2011, IMPLICATIONS EMBODIM, P151
Eberhard-Kaechele M, 2012, ADV CONSC RES, V84, P267
Laban R, 1980, MASTERY MOVEMENT, V4th
Lahmann C, 2010, J ALTERN COMPLEM MED, V16, P47, DOI 10.1089/acm.2009.0084
LANG PJ, 1993, PSYCHOPHYSIOLOGY, V30, P261, DOI 10.1111/j.1469-8986.1993.tb03352.x
LAZARUS RS, 1982, AM PSYCHOL, V37, P1019, DOI 10.1037/0003-066X.37.9.1019
Lee SWS, 2011, CURR DIR PSYCHOL SCI, V20, P307, DOI 10.1177/0963721411422694
Levy F. J., 2005, DANCE MOVEMENT THERA
Lewin K. K., 1935, DYNAMIC THEORY PERSO
Lyons W., 1980, EMOTION, DOI [10.1017/CB09780511609244, DOI 10.1017/CBO9780511609244]
Meier BP, 2012, TOP COGN SCI, V4, P705, DOI 10.1111/j.1756-8765.2012.01212.x
Merleau-Ponty M, 1962, PHENOMENOLOGY PERCEP
Merleau-Ponty M., 1964, PRIMACY PERCEPTION O, P159
Mermillod M., 2011, ISRN NEUROL, V2011, DOI [10.5402/2011/306918, DOI 10.5402/2011/306918]
Neumann R, 2000, J PERS SOC PSYCHOL, V79, P39, DOI 10.1037//0022-3514.79.1.39
Nussbaum Martha C., 2001, UPHEAVALS THOUGHT IN
Pallaro P., 2002, AUTHENTIC MOVEMENT M, P176
Payne H., 2010, COUNS PSYCHOTHER RES, V10, P295, DOI [10.1080/14733140903551645, DOI 10.1080/14733140903551645]
Polanyi M., 1967, TACIT DIMENSION
Pollatos O, 2011, J PSYCHOSOM RES, V71, P232, DOI 10.1016/j.jpsychores.2011.03.012
Prinz J., 2004, GUT REACTIONS PERCEP
REISENZEIN R, 1994, J PERS SOC PSYCHOL, V67, P525, DOI 10.1037//0022-3514.67.3.525
RISKIND JH, 1984, J PERS SOC PSYCHOL, V47, P479, DOI 10.1037/0022-3514.47.3.479
Rogers C., 1951, CLIENT CTR THERAPY I
RYCKMAN RM, 1982, J PERS SOC PSYCHOL, V42, P891, DOI 10.1037//0022-3514.42.5.891
Schmitz H, 2011, PHENOMENOL COGN SCI, V10, P241, DOI 10.1007/s11097-011-9195-1
Schnall S, 2008, PSYCHOL SCI, V19, P1219, DOI 10.1111/j.1467-9280.2008.02227.x
Sheets-Johnstone Maxine, 2000, J CONSCIOUSNESS STUD, V6, P259
Slaby J, 2008, CONSCIOUS COGN, V17, P506, DOI 10.1016/j.concog.2008.03.007
SMITH IM, 1994, PSYCHOL BULL, V116, P259, DOI 10.1037/0033-2909.116.2.259
Solomon A., 2001, NOONDAY DEMON ATLAS
Solomon R., 1976, PASSIONS
Stern D., 1985, INTERPERSONAL WORLD
Stern D. N., 2010, FORMS VITALITY EXPLO
STRACK F, 1988, J PERS SOC PSYCHOL, V54, P768, DOI 10.1037//0022-3514.54.5.768
Taylor G. J., 1997, PSYCHOL MINDEDNESS C, P28
Trevarthen C., 2009, HEALING POWER EMOTIO, P55
VANDERKOLK BA, 1994, HARVARD REV PSYCHIAT, V1, P253, DOI 10.3109/10673229409017088
Wallbott H. G., 1990, MIMIK KONTEXT BEDEUT
WEEKS SJ, 1987, J CHILD PSYCHOL PSYC, V28, P137, DOI 10.1111/j.1469-7610.1987.tb00658.x
Weiss S., 2014, PSYCHOPAHOL IN PRESS
Weizsacker V., 1940, GESTALTKREIS THEORIE
Williams J. M., 2007, MINDFUL WAY DEPRESSI
Williams LE, 2008, SCIENCE, V322, P606, DOI 10.1126/science.1162548
Wollmer MA, 2012, J PSYCHIATR RES, V46, P574, DOI 10.1016/j.jpsychires.2012.01.027
Zajonc R. B., 1984, EMOTIONS COGNITION B, P73
Zhong CB, 2006, SCIENCE, V313, P1451, DOI 10.1126/science.1130726
Zhong CB, 2008, PSYCHOL SCI, V19, P838, DOI 10.1111/j.1467-9280.2008.02165.x
NR 103
TC 3
Z9 3
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUN 6
PY 2014
VL 5
AR 508
DI 10.3389/fpsyg.2014.00508
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA AJ6XO
UT WOS:000337840000001
PM 24936191
ER
PT J
AU Segovia, F
Holt, R
Spencer, M
Gorriz, JM
Ramirez, J
Puntonet, CG
Phillips, C
Chura, L
Baron-Cohen, S
Suckling, J
AF Segovia, Fermin
Holt, Rosemary
Spencer, Michael
Gorriz, Juan M.
Ramirez, Javier
Puntonet, Carlos G.
Phillips, Christophe
Chura, Lindsay
Baron-Cohen, Simon
Suckling, John
TI Identifying endophenotypes of autism: a multivariate approach
SO FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
LA English
DT Article
DE autism spectrum condition; MRI; support vector machine; searchlight;
endophenotype
ID VOXEL-BASED MORPHOMETRY; SPECTRUM DISORDER; LIKELIHOOD ESTIMATION;
GRAY-MATTER; BRAIN; MRI; ACTIVATION; CHILDREN; METAANALYSIS; SVM
AB The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that are also present when comparing controls and the unaffected siblings of ASC individuals. In this work, we used a multivariate methodology applied on magnetic resonance images to look for such differences. The proposed procedure consists of combining a searchlight approach and a support vector machine classifier to identify the differences between three groups of participants in pairwise comparisons: controls, people with ASC and their unaffected siblings. Then we compared those differences selecting spatially collocated as candidate endophenotypes of ASC.
C1 [Segovia, Fermin; Phillips, Christophe] Univ Liege, Cyclotron Res Ctr, Liege, Belgium.
[Segovia, Fermin; Holt, Rosemary; Spencer, Michael; Chura, Lindsay; Baron-Cohen, Simon; Suckling, John] Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge, England.
[Gorriz, Juan M.; Ramirez, Javier] Univ Granada, Dept Signal Theory Networking & Commun, Granada, Spain.
[Puntonet, Carlos G.] Univ Granada, Dept Comp Architecture & Technol, Granada, Spain.
RP Segovia, F (reprint author), Ctr Rech Cyclotron, Bat B30,Allee 6 Aout 8, B-4000 Liege 1, Belgium.
EM fsegovia@ulg.ac.be
RI Gorriz, Juan/C-2385-2012; Ramirez, Javier/B-1836-2012
OI Ramirez, Javier/0000-0002-6229-2921
FU University of Granada under the Genil PYR [2012-10, CEB09-0010];
University of Liege; Clinical Scientist Fellowship from the UK Medical
Research Council (MRC) [G0701919]; UK National Institute for Health
Research Cambridge Biomedical Research Centre; Medical Research Council;
Wellcome Trust; Autism Research Trust
FX This work was partly supported by the University of Granada under the
Genil PYR 2012-10 project (CEI BioTIC GENIL CEB09-0010) and the
University of Liege. The study was also funded by a Clinical Scientist
Fellowship from the UK Medical Research Council (MRC (G0701919)) to
Michael Spencer and by the UK National Institute for Health Research
Cambridge Biomedical Research Centre. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript. Simon Baron-Cohen was supported by the
Medical Research Council, the Wellcome Trust, and the Autism Research
Trust during the period of this work.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Ashburner J, 2000, NEUROIMAGE, V11, P805, DOI 10.1006/nimg.2000.0582
Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
Brambilla P, 2003, BRAIN RES BULL, V61, P557, DOI 10.1016/j.brainresbull.2003.06.001
Cauda F, 2011, J NEUROL NEUROSUR PS, V82, P1304, DOI 10.1136/jnnp.2010.239111
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
CORTES C, 1995, MACH LEARN, V20, P273, DOI 10.1023/A:1022627411411
Courchesne E, 2001, NEUROLOGY, V57, P245
Cuingnet R, 2011, MED IMAGE ANAL, V15, P729, DOI 10.1016/j.media.2011.05.007
Dalton KM, 2007, BIOL PSYCHIAT, V61, P512, DOI 10.1016/j.biopsych.2006.05.019
Duin R.P.W., 2000, P 15 INT C PATT REC, V2, P1, DOI 10.1109/ICPR.2000.906006
Friston K J, 2011, STAT PARAMETRIC MAPP, V1st
Good P., 2000, PERMUTATION TESTS PR, DOI [10.1007/978-1-4757-3235-1, DOI 10.1007/978-1-4757-3235-1]
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
HASHIMOTO T, 1992, BRAIN DEV-JPN, V14, P94
Illan IA, 2011, APPL SOFT COMPUT, V11, P2376, DOI 10.1016/j.asoc.2010.08.019
Jou RJ, 2013, BEHAV BRAIN RES, V251, P163, DOI 10.1016/j.bbr.2013.04.021
Kilman A, 1997, SCHIZOPHR RES, V24, P149, DOI 10.1016/S0920-9964(97)82426-7
Kriegeskorte N, 2006, P NATL ACAD SCI USA, V103, P3863, DOI 10.1073/pnas.0600244103
Kriegeskorte N, 2007, NEUROIMAGE, V38, P649, DOI 10.1016/j.neuroimage.2007.02.022
Lopez MM, 2009, NEUROSCI LETT, V464, P233, DOI 10.1016/j.neulet.2009.08.061
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
Miller R. G., 1966, SIMULTANEOUS STAT IN
Muller KR, 2001, IEEE T NEURAL NETWOR, V12, P181, DOI 10.1109/72.914517
Nickl-Jockschat T, 2012, HUM BRAIN MAPP, V33, P1470, DOI 10.1002/hbm.21299
Nydn A., 2011, RES AUTISM SPECT DIS, V5, P191, DOI [10.1016/j.rasd.2010.03.010, DOI 10.1016/J.RASD.2010.03.010]
Peterson E, 2006, NEUROREPORT, V17, P1289, DOI 10.1097/01.wnr.0000233087.15710.87
Radua J, 2011, PSYCHOL MED, V41, P1539, DOI 10.1017/S0033291710002187
Rojas DC, 2004, AM J PSYCHIAT, V161, P2038, DOI 10.1176/appi.ajp.161.11.2038
Salmond CH, 2003, PHILOS T ROY SOC B, V358, P405, DOI 10.1098/rstb.2002.1210
Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
Segovia F, 2012, MED PHYS, V39, P4395, DOI 10.1118/1.4730289
Segovia F, 2010, NEUROSCI LETT, V474, P58, DOI 10.1016/j.neulet.2010.03.010
SHEN Lin-Lin, 2009, [自动化学报, Acta Automatica Sinica], V35, P350
Spencer MD, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.18
Spencer MD, 2012, BRAIN, V135, P3469, DOI 10.1093/brain/aws229
Swiderski B, 2009, NEUROCOMPUTING, V72, P1575, DOI 10.1016/j.neucom.2008.09.004
Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
Vapnik V, 1995, NATURE STAT LEARNING, DOI [10.1007/978-1-4757-2440-0, DOI 10.1007/978-1-4757-2440-0]
Vapnik V, 1998, STAT LEARNING THEORY
Varma S, 2006, BMC BIOINFORMATICS, V7, DOI 10.1186/1471-2105-7-91
Via E, 2011, ARCH GEN PSYCHIAT, V68, P409, DOI 10.1001/archgenpsychiatry.2011.27
Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001
Zhang N, 2011, COMPUT VIS IMAGE UND, V115, P256, DOI 10.1016/j.cviu.2010.09.007
NR 49
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5188
J9 FRONT COMPUT NEUROSC
JI Front. Comput. Neurosci.
PD JUN 6
PY 2014
VL 8
AR 60
DI 10.3389/fncom.2014.00060
PG 8
WC Mathematical & Computational Biology; Neurosciences
SC Mathematical & Computational Biology; Neurosciences & Neurology
GA AI4JU
UT WOS:000336832300002
PM 24936183
ER
PT J
AU Blumenthal, I
Ragavendran, A
Erdin, S
Klei, L
Sugathan, A
Guide, JR
Manavalan, P
Zhou, JQ
Wheeler, VC
Levin, JZ
Ernst, C
Roeder, K
Devlin, B
Gusella, JF
Talkowski, ME
AF Blumenthal, Ian
Ragavendran, Ashok
Erdin, Serkan
Klei, Lambertus
Sugathan, Aarathi
Guide, Jolene R.
Manavalan, Poornima
Zhou, Julian Q.
Wheeler, Vanessa C.
Levin, Joshua Z.
Ernst, Carl
Roeder, Kathryn
Devlin, Bernie
Gusella, James F.
Talkowski, Michael E.
TI Transcriptional Consequences of 16p11.2 Deletion and Duplication in
Mouse Cortex and Multiplex Autism Families
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; DIFFERENTIAL EXPRESSION ANALYSIS; LONG-RANGE
INTERACTIONS; COPY-NUMBER VARIATIONS; SPECTRUM DISORDERS; INTELLECTUAL
DISABILITY; MICRODELETION SYNDROME; ENRICHMENT ANALYSIS; FUNCTIONAL
IMPACT; R PACKAGE
AB Reciprocal copy-number variation (CNV) of a 593 kb region of 16p11.2 is a common genetic cause of autism spectrum disorder (ASD), yet it is not completely penetrant and can manifest in a wide array of phenotypes. To explore its molecular consequences, we performed RNA sequencing of cerebral cortex from mouse models with CNV of the syntenic 7qF3 region and lymphoblast lines from 34 members of 7 multiplex ASD-affected families harboring the 16p11.2 CNV. Expression of all genes in the CNV region correlated well with their DNA copy number, with no evidence of dosage compensation. We observed effects on gene expression outside the CNV region, including apparent positional effects in cis and in trans at genomic segments with evidence of physical interaction in Hi-C chromosome conformation data. One of the most significant positional effects was telomeric to the 16p11.2 CNV and includes the previously described "distal" 16p11.2 microdeletion. Overall, 16p11.2 CNV was associated with altered expression of genes and networks that converge on multiple hypotheses of ASD pathogenesis, including synaptic function (e.g., NRXN1, NRXN3), chromatin modification (e.g., CHD8, EHMT1, MECP2), transcriptional regulation (e.g., TCF4, SATB2), and intellectual disability (e.g., FMR1, CEP290). However, there were differences between tissues and species, with the strongest effects being consistently within the CNV region itself. Our analyses suggest that through a combination of indirect regulatory effects and direct effects on nuclear architecture, alteration of 16p11.2 genes disrupts expression networks that involve other genes and pathways known to contribute to ASD, suggesting an overlap in mechanisms of pathogenesis.
C1 [Blumenthal, Ian; Ragavendran, Ashok; Erdin, Serkan; Sugathan, Aarathi; Guide, Jolene R.; Manavalan, Poornima; Wheeler, Vanessa C.; Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Boston, MA 02114 USA.
[Blumenthal, Ian; Ragavendran, Ashok; Erdin, Serkan; Sugathan, Aarathi; Guide, Jolene R.; Manavalan, Poornima; Wheeler, Vanessa C.; Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Klei, Lambertus; Devlin, Bernie] Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA.
[Levin, Joshua Z.; Gusella, James F.; Talkowski, Michael E.] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02141 USA.
[Ernst, Carl] McGill Univ, Dept Psychiat, Douglas Hosp, Res Inst, Verdun, PQ H4H 1R3, Canada.
[Zhou, Julian Q.; Roeder, Kathryn] Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA.
[Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02141 USA.
[Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Dept Genet, Boston, MA 02141 USA.
[Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02141 USA.
[Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02141 USA.
[Gusella, James F.; Talkowski, Michael E.] Harvard Univ, Sch Med, Boston, MA 02141 USA.
RP Talkowski, ME (reprint author), Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Boston, MA 02114 USA.
EM talkowski@chgr.mgh.harvard.edu
RI Erdin, Serkan/B-4988-2008
OI Erdin, Serkan/0000-0001-6587-2625
FU National Institute of Mental Health [MH095867, R37 MH057881,
1U24MH081810]; Simons Foundation for Autism Research; Nancy Lurie Marks
Family Foundation; Brain and Behavorial Research Foundation (NARSAD);
Autism Genetic Resource Exchange (AGRE) and Autism Speaks
FX We thank A. Mills for development of the mouse models and AGRE for
providing biological materials. These studies were supported by the
National Institute of Mental Health (MH095867 to M.E.T., R37 MH057881 to
B.D. and K.R.), the Simons Foundation for Autism Research (M.E.T.,
J.F.G.), the Nancy Lurie Marks Family Foundation (M.E.T., J.F.G.), and
the Brain and Behavorial Research Foundation (NARSAD; M.E.T.). We also
acknowledge support from the Autism Genetic Resource Exchange (AGRE) and
Autism Speaks (to J.F.G.). We gratefully acknowledge the resources
provided by the AGRE consortium and the participating AGRE families. The
Autism Genetic Resource Exchange (AGRE) is a program of Autism Speaks
and is supported, in part, by grant 1U24MH081810 from the National
Institute of Mental Health to Clara M. Lajonchere (PI).
CR Abrahams BS, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-36
Agresti A., 2002, CATEGORICAL DATA ANA
Anders S, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-10-r106
Andrews S., 2010, FASTQC QUALITY CONTR
[Anonymous], 2011, STAND GUID BEST PRAC
Atkins DC, 2013, PSYCHOL ADDICT BEHAV, V27, P166, DOI 10.1037/a0029508
Barge-Schaapveld DQCM, 2011, AM J MED GENET A, V155A, P1066, DOI 10.1002/ajmg.a.33991
Berry R, 2011, HUM MOL GENET, V20, P917, DOI 10.1093/hmg/ddq530
Blaker-Lee A, 2012, DIS MODEL MECH, V5, P834, DOI 10.1242/dmm.009944
Chen EY, 2013, BMC BIOINFORMATICS, V14, DOI 10.1186/1471-2105-14-128
Colnaghi R, 2011, SEMIN CELL DEV BIOL, V22, P875, DOI 10.1016/j.semcdb.2011.07.010
Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
DeLuca DS, 2012, BIOINFORMATICS, V28, P1530, DOI 10.1093/bioinformatics/bts196
Di Y, 2011, STAT APPL GENET MOL, V10, P1
Girirajan S, 2013, HUM MOL GENET, V22, P2870, DOI 10.1093/hmg/ddt136
Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
Gu Wenli, 2008, Pathogenetics, V1, P4, DOI 10.1186/1755-8417-1-4
Harewood L, 2010, GENOME RES, V20, P554, DOI 10.1101/gr.103622.109
Hodge JC, 2014, MOL PSYCHIATR, V19, P368, DOI 10.1038/mp.2013.42
Horev G, 2011, P NATL ACAD SCI USA, V108, P17076, DOI 10.1073/pnas.1114042108
Huang W., 2009, NAT PROTOC, V4, P44, DOI DOI 10.1038/NPR0T.2008.211
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
Jiang LC, 2011, GENOME RES, V21, P1543, DOI 10.1101/gr.121095.111
Kanehisa M, 2012, NUCLEIC ACIDS RES, V40, pD109, DOI 10.1093/nar/gkr988
Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
Kleefstra T, 2012, AM J HUM GENET, V91, P73, DOI 10.1016/j.ajhg.2012.05.003
Kleefstra T, 2006, AM J HUM GENET, V79, P370, DOI 10.1086/505693
Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
Langfelder P., 2012, J STAT SOFTW, V46, P46
Levin JZ, 2010, NAT METHODS, V7, P709, DOI [10.1038/nmeth.1491, 10.1038/NMETH.1491]
Lieberman-Aiden E, 2009, SCIENCE, V326, P289, DOI 10.1126/science.1181369
Lintas C, 2012, NEUROBIOL DIS, V45, P57, DOI 10.1016/j.nbd.2010.11.010
Lund S.P., 2012, STAT APPL GENET MOL, V11, P11, DOI DOI 10.1515/1544-6115.1826
Luo R, 2012, AM J HUM GENET, V91, P38, DOI 10.1016/j.ajhg.2012.05.011
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Matthews L, 2009, NUCLEIC ACIDS RES, V37, pD619, DOI 10.1093/nar/gkn863
McCullagh P., 1989, GEN LINEAR MODELS
Mi HY, 2005, NUCLEIC ACIDS RES, V33, pD284, DOI 10.1093/nar/gki078
Mullegama SV, 2014, EUR J HUM GENET, V22, P57, DOI 10.1038/ejhg.2013.67
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Parkhomchuk D, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkp596
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Pruitt KD, 2014, NUCLEIC ACIDS RES, V42, pD756, DOI 10.1093/nar/gkt1114
Quinlan AR, 2010, BIOINFORMATICS, V26, P841, DOI 10.1093/bioinformatics/btq033
Ronan JL, 2013, NAT REV GENET, V14, P347, DOI 10.1038/nrg3413
Rosenfeld JA, 2013, GENET MED, V15, P478, DOI 10.1038/gim.2012.164
Rossin EJ, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001273
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Shannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303
Soneson C, 2013, BMC BIOINFORMATICS, V14, DOI 10.1186/1471-2105-14-91
Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
Supek F, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021800
Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Vazquez AI, 2010, J ANIM SCI, V88, P497, DOI 10.2527/jas.2009-1952
Venables W. N., 2002, MODERN APPL STAT S, V4th
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Voineagu I, 2012, NEUROBIOL DIS, V45, P69, DOI 10.1016/j.nbd.2011.07.017
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Williams SR, 2010, EUR J HUM GENET, V18, P436, DOI 10.1038/ejhg.2009.199
Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
Young MD, 2012, BIOINFORMATICS FOR HIGH THROUGHPUT SEQUENCING, P169, DOI 10.1007/978-1-4614-0782-9_10
Zeitz MJ, 2013, NUCLEUS-AUSTIN, V4, P487, DOI 10.4161/nucl.27364
Zhong Silin, 2011, Cold Spring Harb Protoc, V2011, P940, DOI 10.1101/pdb.prot5652
NR 70
TC 7
Z9 7
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
EI 1537-6605
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD JUN 5
PY 2014
VL 94
IS 6
BP 870
EP 883
DI 10.1016/j.ajhg.2014.05.004
PG 14
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ0HK
UT WOS:000337331200007
PM 24906019
ER
PT J
AU Raff, M
AF Raff, Martin
TI Open questions: What has genetics told us about autism spectrum
disorders?
SO BMC BIOLOGY
LA English
DT Article
ID CONVERGENCE
AB Some of the most interesting questions in biology today, in my view, derive from the real advances in neuropsychiatry that have come largely from human genetics. Research in autism spectrum disorders (ASDs) has been leading the way, mainly because it has become especially well funded and has recently attracted many outstanding scientists. (I must make it clear that I am an outsider in this field, as I have never worked on any neuropsychiatric disorder).
C1 UCL, MRC Lab Mol & Cell Biol, London WC1E 6BT, England.
RP Raff, M (reprint author), UCL, MRC Lab Mol & Cell Biol, Gower St, London WC1E 6BT, England.
EM m.raff@ucl.ac.uk
CR Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108
Guillaume H, 2013, ANNU REV GENOM HUM G, V14, P191
Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
Krumm N, 2014, TRENDS NEUROSCI, V37, P95, DOI 10.1016/j.tins.2013.11.005
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
Pinto D, 2014, AM J HUM GENET, V94, P677, DOI 10.1016/j.ajhg.2014.03.018
Ronemus M, 2014, NAT REV GENET, V15, P133, DOI 10.1038/nrg3585
Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
NR 9
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7007
J9 BMC BIOL
JI BMC Biol.
PD JUN 5
PY 2014
VL 12
AR 45
DI 10.1186/1741-7007-12-45
PG 3
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AI4DH
UT WOS:000336815300001
PM 24903674
ER
PT J
AU Pineda, JA
Carrasco, K
Datko, M
Pillen, S
Schalles, M
AF Pineda, Jaime A.
Carrasco, Karen
Datko, Mike
Pillen, Steven
Schalles, Matt
TI Neurofeedback training produces normalization in behavioural and
electrophysiological measures of high-functioning autism
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE mirror neuron system; sensorimotor systems; electroencephalogram mu
rhythms; mu suppression index
ID MIRROR-NEURON SYSTEM; SPECTRUM DISORDERS; MU-RHYTHMS; CORTICAL RHYTHMS;
EEG BIOFEEDBACK; ALPHA RHYTHMS; BRAIN; CHILDREN; SUPPRESSION; MOVEMENT
AB Autism spectrum disorder (ASD) is a neurodevelopmental condition exhibiting impairments in behaviour, social and communication skills. These deficits may arise from aberrant functional connections that impact synchronization and effective neural communication. Neurofeedback training (NFT), based on operant conditioning of the electroencephalogram (EEG), has shown promise in addressing abnormalities in functional and structural connectivity. We tested the efficacy of NFT in reducing symptoms in children with ASD by targeting training to the mirror neuron system (MNS) via modulation of EEG mu rhythms. The human MNS has provided a neurobiological substrate for understanding concepts in social cognition relevant to behavioural and cognitive deficits observed in ASD. Furthermore, mu rhythms resemble MNS phenomenology supporting the argument that they are linked to perception and action. Thirty hours of NFT on ASD and typically developing (TD) children were assessed. Both groups completed an eyes-open/-closed EEG session as well as a mu suppression index assessment before and after training. Parents filled out pre- and post-behavioural questionnaires. The results showed improvements in ASD subjects but not in TDs. This suggests that induction of neuroplastic changes via NFT can normalize dysfunctional mirroring networks in children with autism, but the benefits are different for TD brains.
C1 [Pineda, Jaime A.] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA.
Univ Calif San Diego, Dept Grp Neurosci, La Jolla, CA 92093 USA.
RP Pineda, JA (reprint author), Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA.
EM pineda@cogsci.ucsd.edu
FU Congressionally Directed Medical Research Programme [AR093335]
FX We thank the Congressionally Directed Medical Research Programme for an
Autism Research Programme (ARP) Idea Award (AR093335) to J.P.
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
Acar ZA, 2010, J NEUROSCI METH, V190, P258, DOI 10.1016/j.jneumeth.2010.04.031
Allely Clare S, 2011, Practitioner, V255, P27
Altschuler EL, 1998, J COGNITIVE NEUROS S, V9, P91
Arnstein D, 2011, J NEUROSCI, V31, P14243, DOI 10.1523/JNEUROSCI.0963-11.2011
Babiloni C, 2006, HUM BRAIN MAPP, V27, P162, DOI 10.1002/hbm.20175
Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Bernier R, 2007, BRAIN COGNITION, V64, P228, DOI 10.1016/j.bandc.2007.03.004
Carpenter M., 1998, MONOGR SOC RES CHILD, V63, P1, DOI DOI 10.2307/1166214
Chaste Pauline, 2012, Dialogues Clin Neurosci, V14, P281
Coben R, 2010, APPL PSYCHOPHYS BIOF, V35, P83, DOI 10.1007/s10484-009-9117-y
Coben R, 2010, APPL PSYCHOPHYS BIOF, V35, P13, DOI 10.1007/s10484-009-9102-5
Cochin S, 1999, EUR J NEUROSCI, V11, P1839, DOI 10.1046/j.1460-9568.1999.00598.x
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
DASILVA FHL, 1980, ELECTROEN CLIN NEURO, V50, P449
DIPELLEGRINO G, 1992, EXP BRAIN RES, V91, P176
Francuz P, 2011, NEUROSCI LETT, V495, P39, DOI 10.1016/j.neulet.2011.03.031
Fuchs T, 2003, APPL PSYCHOPHYS BIOF, V28, P1, DOI 10.1023/A:1022353731579
Gallese V, 2003, PSYCHOPATHOLOGY, V36, P171, DOI 10.1159/000072786
GASTAUT H, 1952, Rev Neurol (Paris), V87, P176
GASTAUT HJ, 1954, ELECTROEN CLIN NEURO, V6, P433, DOI 10.1016/0013-4694(54)90058-9
Gomot M, 2012, INT J PSYCHOPHYSIOL, V83, P240, DOI 10.1016/j.ijpsycho.2011.09.017
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Hari R, 1997, INT J PSYCHOPHYSIOL, V26, P51, DOI 10.1016/S0167-8760(97)00755-1
Heinrich H, 2004, BIOL PSYCHIAT, V55, P772, DOI 10.1016/j.biopsych.2003.11.013
Hickok G, 2009, J COGNITIVE NEUROSCI, V21, P1229, DOI 10.1162/jocn.2009.21189
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
Jarusiewicz B, 2003, APPL PSYCHOPHYS BIOF, V28, P311
Keuken MC, 2011, BRAIN RES, V1383, P196, DOI 10.1016/j.brainres.2011.01.073
Keysers C, 2003, EXP BRAIN RES, V153, P628, DOI 10.1007/s00221-003-1603-5
Kouijzer MEJ, 2009, RES AUTISM SPECT DIS, V3, P496, DOI 10.1016/j.rasd.2008.10.003
Le Bel RM, 2009, J COMMUN DISORD, V42, P299, DOI 10.1016/j.jcomdis.2009.03.011
LUBAR JF, 1981, ARCH NEUROL-CHICAGO, V38, P700
LUBAR JO, 1984, BIOFEEDBACK SELF-REG, V9, P1, DOI 10.1007/BF00998842
Martineau J, 2010, BRAIN RES, V1320, P168, DOI 10.1016/j.brainres.2010.01.035
Michel CM, 2004, CLIN NEUROPHYSIOL, V115, P2195, DOI 10.1016/j.clinph.2004.06.001
Monderer RS, 2002, EPILEPSY BEHAV, V3, P214, DOI 10.1016/S1525-5050(02)00001-X
Moore NC, 2000, CLIN ELECTROENCEPHAL, V31, P1
Neuper C, 2006, PROG BRAIN RES, V159, P211, DOI 10.1016/S0079-6123(06)59014-4
Nishitani N, 2004, ANN NEUROL, V55, P558, DOI 10.1002/ana.20031
Nunez PL, 2001, HUM BRAIN MAPP, V13, P125, DOI 10.1002/hbm.1030
Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
Oberman LM, 2007, SOC COGN AFFECT NEUR, V2, P62, DOI 10.1093/scan/nsl022
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Pfurtscheller G, 1997, INT J PSYCHOPHYSIOL, V26, P121, DOI 10.1016/S0167-8760(97)00760-5
Pfurtscheller G, 2000, CLIN NEUROPHYSIOL, V111, P1873, DOI 10.1016/S1388-2457(00)00428-4
Pineda JA, 2012, MED HYPOTHESES, V79, P790, DOI 10.1016/j.mehy.2012.08.031
Pineda JA, 2008, RES AUTISM SPECT DIS, V2, P557, DOI 10.1016/j.rasd.2007.12.003
Pineda JA, 2005, BRAIN RES REV, V50, P57, DOI 10.1016/j.brainresrev.2005.04.005
Pineda JA, 2000, IEEE T REHABIL ENG, V8, P219, DOI 10.1109/86.847822
Posthuma D, 2013, CURR OPIN NEUROL, V26, P111, DOI 10.1097/WCO.0b013e32835f19c3
Raymaekers R, 2009, BRAIN RES, V1304, P113, DOI 10.1016/j.brainres.2009.09.068
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
Schoenberger NE, 2001, J HEAD TRAUMA REHAB, V16, P260, DOI 10.1097/00001199-200106000-00005
Sichel A., 1995, J NEUROTHERAPY, V1, P60, DOI DOI 10.1300/J184V01N01_08
Siegel DJ, 2010, INT J GROUP PSYCHOTH, V60, P483, DOI 10.1521/ijgp.2010.60.4.483
Muthukumaraswamy SD, 2008, PSYCHOPHYSIOLOGY, V45, P896, DOI 10.1111/j.1469-8986.2008.00711.x
Sokhadze TM, 2008, APPL PSYCHOPHYS BIOF, V33, P1, DOI 10.1007/s10484-007-9047-5
Sterman MB, 2000, CLIN ELECTROENCEPHAL, V31, P45
STERMAN MB, 1972, ELECTROEN CLIN NEURO, V33, P89, DOI 10.1016/0013-4694(72)90028-4
Strom SP, 2010, MOL PSYCHIATR, V15, P996, DOI 10.1038/mp.2009.41
Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
Townsend J, 2001, COGNITIVE BRAIN RES, V11, P127, DOI 10.1016/S0926-6410(00)00072-0
Turella L, 2009, BRAIN LANG, V108, P10, DOI 10.1016/j.bandl.2007.11.002
Umilta MA, 2001, NEURON, V31, P155, DOI 10.1016/S0896-6273(01)00337-3
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
Wing K, 2001, Top Stroke Rehabil, V8, P45
Yoder P, 2009, J AUTISM DEV DISORD, V39, P1381, DOI 10.1007/s10803-009-0753-0
NR 72
TC 2
Z9 2
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD JUN 5
PY 2014
VL 369
IS 1644
SI SI
AR 20130183
DI 10.1098/rstb.2013.0183
PG 10
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AG6XY
UT WOS:000335563600010
PM 24778378
ER
PT J
AU Weltzin, MM
Huang, YZ
Schulte, MK
AF Weltzin, Maegan M.
Huang, Yanzhou
Schulte, Marvin K.
TI Allosteric modulation of alpha4beta2 nicotinic acetylcholine receptors
by HEPES
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Alpha4beta2; Alpha7; Nicotinic acetylcholine receptor; Ligand gated ion
channels; Positive allosteric modulation; HEPES;
desformylflustrabromine; dFbr; Two-electrode voltage clamp; Mutagenesis
ID ALTERNATE STOICHIOMETRIES; CRYSTAL-STRUCTURE; RB-86(+) EFFLUX;
ION-CHANNEL; ALPHA-4-BETA-2; BINDING; SUBUNIT; BUFFER; TRIS;
DESFORMYLFLUSTRABROMINE
AB A number of new positive allosteric modulators (PAMs) have been reported that enhance responses of neuronal alpha7 and alpha4beta2 nicotinic acetylcholine receptor subtypes to orthosteric ligands.PAMs represent promising new leads for the development of therapeutic agents for disorders involving alterations in nicotinic neurotransmission including Autism, Alzheimer's and Parkinson's disease. During our recent studies of alpha4beta2 PAMs, we identified a novel effect of 4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES). The effects of HEPES were evaluated in a phosphate buffered recording solution using two-electrode voltage clamp techniques and alpha4beta2 and alpha7 nicotinic acetylcholine receptor subtypes expressed in Xenopus laevis oocytes. Acetylcholine induced responses of high-sensitivity alpha4beta2 receptors were potentiated 190% by co-exposure to HEPES. Responses were inhibited at higher concentrations (bell-shaped concentration/response curve). Coincidentally, at concentrations of HEPES typically used in oocyte recording (5-10 mM), the potentiating effects of HEPES are matched by its inhibitory effects, thus producing no net effect. Mutagenesis results suggest HEPES potentiates the high-sensitivity stoichiometry of the alpha4beta2 receptors through action at the beta2 1/ beta2- interface and is dependent on residue beta2D218. HEPES did not potentiate low sensitivity alpha4beta2 receptors and did not produce any observable effect on acetylcholine induced responses on alpha7 nicotinic acetylcholine receptors. (C) 2012 Elsevier B.V. Allrightsreserved.
C1 [Weltzin, Maegan M.; Huang, Yanzhou; Schulte, Marvin K.] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA.
RP Schulte, MK (reprint author), Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA.
EM mkschulte@alaska.edu
FU National Center for Research Resources [5P20RR016466]; National
Institutes of Neurological Disorders and Stroke [1R01NS057366,
1R01NS066059]; Components of the National Institutes of Health (NIH)
FX This research was supported by grants from the National Center for
Research Resources (5P20RR016466, Alaska INBRE Program) and The National
Institutes of Neurological Disorders and Stroke[1R01NS066059 and
1R01NS057366], Components of the National Institutes of Health (NIH).
CR Adams CE, 2007, FRONT BIOSCI, V12, P4755, DOI 10.2741/2424
AUBERT I, 1992, J NEUROCHEM, V58, P529, DOI 10.1111/j.1471-4159.1992.tb09752.x
Bertrand D, 2007, BIOCHEM PHARMACOL, V74, P1155, DOI 10.1016/j.bcp.2007.07.011
Brejc K, 2001, NATURE, V411, P269, DOI 10.1038/35077011
Butt CM, 2002, J NEUROCHEM, V83, P48, DOI 10.1046/j.1471-4159.2002.01135.x
Court J, 2001, BIOL PSYCHIAT, V49, P175, DOI 10.1016/S0006-3223(00)01116-1
Desmarais WT, 2002, STRUCTURE, V10, P1063, DOI 10.1016/S0969-2126(02)00810-9
Gab J, 2010, J CHROMATOGR B, V878, P1382, DOI 10.1016/j.jchromb.2010.01.043
Garcia DA, 2008, EUR J PHARMACOL, V600, P26, DOI 10.1016/j.ejphar.2008.10.013
Ghalanbor Z, 2008, PROTEIN PEPTIDE LETT, V15, P212
GOOD NE, 1966, BIOCHEMISTRY-US, V5, P467, DOI 10.1021/bi00866a011
Gotti C, 2008, MOL PHARMACOL, V73, P1796, DOI 10.1124/mol.108.045203
Harvey RJ, 1999, J PHYSIOL-LONDON, V520, P53, DOI 10.1111/j.1469-7793.1999.00053.x
Hsiao B, 2001, J NEUROSCI, V21, P1848
Joshi PR, 2004, J NEUROSCI METH, V132, P69, DOI 10.1016/j.jneumeth.2003.09.002
Kasai M, 1998, JPN J PHYSIOL, V48, P91, DOI 10.2170/jjphysiol.48.91
Kim JS, 2007, BIOORG MED CHEM LETT, V17, P4855, DOI 10.1016/j.bmcl.2007.06.047
Levin ED, 2007, BIOCHEM PHARMACOL, V74, P1182, DOI 10.1016/j.bcp.2007.07.019
Li M, 2002, FEBS LETT, V513, P247, DOI 10.1016/S0014-5793(02)02322-0
Liu Q, 2008, ACTA PHARMACOL SIN, V29, P305, DOI 10.1111/j.1745-7254.2008.00760.x
Luo SH, 2010, MOL PHARMACEUT, V7, P412, DOI 10.1021/mp900193e
Marks MJ, 2000, NEUROPHARMACOLOGY, V39, P2632, DOI 10.1016/S0028-3908(00)00115-5
Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003
Moroni M, 2008, J NEUROSCI, V28, P6884, DOI 10.1523/JNEUROSCI.1228-08.2008
Moroni M, 2006, J MOL NEUROSCI, V30, P95, DOI 10.1385/JMN/30:1-2:95
Moroni M, 2006, MOL PHARMACOL, V70, P755, DOI 10.1124/mol.106.023044
Nelson ME, 2003, MOL PHARMACOL, V63, P332, DOI 10.1124/mol.63.2.332
Nury H, 2011, NATURE, V469, P428, DOI 10.1038/nature09647
Pandya A., 2011, J MOL NEUROSCI
Pavlovicz RE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024949
Picciotto MR, 2001, PHARMACOL THERAPEUT, V92, P89, DOI 10.1016/S0163-7258(01)00161-9
POOLE CA, 1982, IN VITRO CELL DEV B, V18, P755
Sala F, 2005, NEUROSCI LETT, V373, P144, DOI 10.1016/j.neulet.2004.10.002
Smulders CJGM, 2005, EUR J PHARMACOL, V509, P97, DOI 10.1016/j.ejphar.2004.12.037
Taly A, 2009, NAT REV DRUG DISCOV, V8, P733, DOI 10.1038/nrd2927
Tapia L, 2007, MOL PHARMACOL, V71, P769, DOI 10.1124/mol.106.030445
Weltzin MM, 2010, J PHARMACOL EXP THER, V334, P917, DOI 10.1124/jpet.110.167684
Wonnacott S, 1997, TRENDS NEUROSCI, V20, P92, DOI 10.1016/S0166-2236(96)10073-4
YAMAMOTO D, 1987, PROC R SOC SER B-BIO, V230, P93, DOI 10.1098/rspb.1987.0011
Zwart R, 1998, MOL PHARMACOL, V54, P1124
NR 40
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUN 5
PY 2014
VL 732
BP 159
EP 168
DI 10.1016/j.ejphar.2012.06.001
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AG5FD
UT WOS:000335443900018
PM 22732654
ER
PT J
AU Fridin, M
Belokopytov, M
AF Fridin, Marina
Belokopytov, Mark
TI Embodied Robot versus Virtual Agent: Involvement of Preschool Children
in Motor Task Performance
SO INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
LA English
DT Article
ID CEREBRAL-PALSY; INFLUENCE RECOGNITION; BODY LANGUAGE; GENDER;
REHABILITATION; MOVEMENT; EXPRESSION; AUTISM
AB Embodied robots are known to be preferable in most cases to their virtual agents for interaction with and performance by human subjects. This study compared the efficacy of an embodied robot-coacher and its virtual agent in involving preschool children in the performance of playlike motor tasks. The robot or its virtual agent demonstrated movements, asked the children to repeat them, and provided positive feedback on their performance. The difficulty of the motor tasks was increased over the course of the session. Two groups of children were studied, one of them with and the other without previous experience of interaction with the embodied robot. In the experienced group, involvement in motor tasks was successfully induced by both the embodied robot and its virtual agent, but the children interacted less well with the virtual agent than with the embodied robot. Children in the inexperienced group did not interact at all during the experiment with the virtual agent. Because participants in the experiment were preschool children in their natural environment, this study proposes the combined use of an embodied robot and its virtual agent for motor involvement.
C1 [Fridin, Marina] Ariel Univ, Dept Ind Engn & Management, IL-40700 Kiryat Hamada, Ariel, Israel.
[Belokopytov, Mark] Assaf Harofeh Med Ctr, Human Mot Anal Lab, IL-70300 Zerifin, Israel.
RP Fridin, M (reprint author), Ariel Univ, Dept Ind Engn & Management, POB 3, IL-40700 Kiryat Hamada, Ariel, Israel.
EM marinafridin@gmail.com
FU administration of the Ariel University
FX We are grateful to the staff of Liora's Kindergarten at Neeman Towers
(Tel Aviv, Israel) for their cooperation. We thank the administration of
the Ariel University for support.
CR Anderson F, 2010, STUD HEALTH TECHNOL, V154, P229, DOI 10.3233/978-1-60750-561-7-229
Argyle Michael, 1976, GAZE AND MUTUAL GAZE
Bar-Haim S, 2010, CLIN REHABIL, V24, P1009, DOI 10.1177/0269215510371428
Bar-Haim S, 2008, DISABIL REHABIL, V30, P1420, DOI 10.1080/09638280701562885
Bartneck C., 2004, P DES EM 2004, P32
Bhushan N, 1999, BIOL CYBERN, V81, P39, DOI 10.1007/s004220050543
Braun DA, 2009, CURR BIOL, V19, P352, DOI 10.1016/j.cub.2009.01.036
Breazeal C., 2004, P INT C INT ROB SYST, V4, P3559, DOI DOI 10.1109/IR0S.2004.1389967
Choi G, 2012, INT J HUM-COMPUT INT, V28, P399, DOI 10.1080/10447318.2011.601973
Deutsch JE, 2011, TOP STROKE REHABIL, V18, P701, DOI 10.1310/tsr1806-701
Feil-Seifer D., 2011, Proceedings of the 2011 6th ACM/IEEE International Conference on Human-Robot Interaction (HRI 2011), DOI 10.1145/1957656.1957785
Franklin DW, 2008, J NEUROSCI, V28, P11165, DOI 10.1523/JNEUROSCI.3099-08.2008
Fridin M., 2011, P WORKSH ROB NEUR RE
Goodrich M. A., 2011, Proceedings of the 2011 6th ACM/IEEE International Conference on Human-Robot Interaction (HRI 2011), DOI 10.1145/1957656.1957702
Gouaillier D, 2009, IEEE INT C ROB AUT, P769
Heerink M., 2008, ADV ROBOTICS, V23, P1909
Heerink M, 2008, 2008 IEEE/RSJ INTERNATIONAL CONFERENCE ON ROBOTS AND INTELLIGENT SYSTEMS, VOLS 1-3, CONFERENCE PROCEEDINGS, P2724, DOI 10.1109/IROS.2008.4651232
UEKI N, 1994, SYST COMPUT JPN, V25, P95
Hijmans JM, 2011, J REHABIL RES DEV, V48, P1005, DOI 10.1682/JRRD.2010.06.0109
Huber M, 2010, IEEE T INF TECHNOL B, V14, P526, DOI 10.1109/TITB.2009.2038995
Israeli Ministry of Education, 2012, QUEST REF ORD SPEC N
Johnson RD, 2008, INT J HUM-COMPUT INT, V24, P595, DOI 10.1080/10447310802205784
Jung Y., 2004, P PRESENCE 2004, P80, DOI DOI 10.1145/1349822.1349866
Kemp C. C., 2008, SPRINGER HDB ROBOTIC, P1307, DOI 10.1007/978-3-540-30301-5_57
Ketelaar M, 2001, PHYS THER, V81, P1534
Kirby RS, 2011, RES DEV DISABIL, V32, P462, DOI 10.1016/j.ridd.2010.12.042
Klamer T, 2011, L N INST COMP SCI SO, V59, P74
Lee J., 2011, P 6 INT C HUM ROB IN, P297, DOI 10.1145/1957656.1957780
Lee KM, 2006, INT J HUM-COMPUT ST, V64, P962, DOI 10.1016/j.ijhcs.2006.05.002
MAGILL RA, 1978, PERCEPT MOTOR SKILL, V46, P107
McWhorter J. W., 2010, PHYSIOTHERAPY THEORY, V27, P422
Meeren HKM, 2005, P NATL ACAD SCI USA, V102, P16518, DOI 10.1073/pnas.0507650102
Mihelj M, 2009, 2009 VIRTUAL REHABILITATION INTERNATIONAL CONFERENCE, P160, DOI 10.1109/ICVR.2009.5174225
Mutlu B., 2006, 6 IEEE RAS INT C HUM, P518
Nalin M., 2011, P IEEE ACM HUM ROB I
Naon D., 2000, RR35500 JDC BROOKD I
Pereira A, 2008, P 7 INT JOINT C AUT, V3, P1253
Pierno AC, 2008, NEUROPSYCHOLOGIA, V46, P448, DOI 10.1016/j.neuropsychologia.2007.08.020
Schmidt RA, 1997, HUM FACTORS, V39, P509, DOI 10.1518/001872097778667979
SHADMEHR R, 1994, J NEUROSCI, V14, P3208
Shi L., 2008, INT J VIRTUAL REALIT, V7, P49
Shim J., 2011, P IEEE INT S ROB HUM, P455
Shinozawa K, 2005, INT J HUM-COMPUT ST, V62, P267, DOI 10.1016/j.ijhcs.2004.11.003
Shukla-Mehta S, 2010, FOCUS AUTISM DEV DIS, V25, P23, DOI 10.1177/1088357609352901
Siino RM, 2005, IEEE INT CONF ROBOT, P2773
Straker LM, 2009, INT J HUM-COMPUT INT, V25, P713, DOI 10.1080/10447310903025495
Sullivan KI, 2008, PHYS THER, V88, P720, DOI 10.2522/ptj.20070196
Takeuchi J., 2006, P 2006 IEEE RSJ INT, P3964
Tapus A., 2009, P 18 IEEE INT S ROB, P103
Tartaro A., 2008, P 8 INT C LEARN SCI, V2, P382
Thota S., 2011, P IEEE INT S ROB HUM, P253
Tsui K., 2008, PERMIS 08 P 8 WORKSH
U. S. Food and Drug Administration, 2006, GUID IND INV REV
U. S. Food and Drug Adminstration, 2004, INN STAGN CHALL OPP
Van den Stock J, 2007, EMOTION, V7, P487, DOI 10.1037/1528-3542.7.3.487
Van den Stock J, 2008, BRAIN RES, V1242, P185, DOI 10.1016/j.brainres.2008.05.040
Villano M., 2011, Proceedings of the 2011 6th ACM/IEEE International Conference on Human-Robot Interaction (HRI 2011), DOI 10.1145/1957656.1957770
Volman MJM, 2002, CLIN REHABIL, V16, P684, DOI 10.1191/0269215502cr540oa
Wainer J., 2007, P INT C HUM ROB INT, P872, DOI DOI 10.1109/R0MAN.2007.4415207
Wainer J., 2006, P IEEE INT WORKSH RO, P117
Wei FYF, 2009, LEARN MEDIA TECHNOL, V34, P27, DOI 10.1080/17439880902759893
Weinstein C. J., 1991, PHYS THER, V71, P140
Woods S.N., 2006, P 15 IEEE INT S ROB, P51, DOI DOI 10.1109/ROMAN.2006.314394
World Health Organisation, 2001, INT CLASS FUNCT DIS
Yaakobi Y., 2011, P INT C COMP VIS ROB
NR 65
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1044-7318
EI 1532-7590
J9 INT J HUM-COMPUT INT
JI Int. J. Hum.-Comput. Interact.
PD JUN 3
PY 2014
VL 30
IS 6
BP 459
EP 469
DI 10.1080/10447318.2014.888500
PG 11
WC Computer Science, Cybernetics; Ergonomics
SC Computer Science; Engineering
GA AF7QE
UT WOS:000334908800003
ER
PT J
AU de Graef, O
AF de Graef, Ortwin
TI "I Know He Knows I Know He Knows I Am": Suspension of Disbelief in A. L.
Kennedy
SO PARTIAL ANSWERS-JOURNAL OF LITERATURE AND THE HISTORY OF IDEAS
LA English
DT Article
ID AUTISM
C1 Katholieke Univ Leuven, Louvain, Belgium.
RP de Graef, O (reprint author), Katholieke Univ Leuven, Louvain, Belgium.
CR Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Baron-Cohen Simon, 2012, ZERO DEGREE EMPATHY
Bergerac Cyrano de, 2013, VOYAGE MOON
Borthwick David, 2007, EDINBURGH COMPANION, P264
Cavell Stanley, 1988, QUEST ORDINARY LINES
Coleridge Samuel Taylor, 1983, COMPLETE WORKS ST CO, VVII
Coleridge Samuel Taylor, 2012, POEMS ST COLERIDGE, p[186, 362]
Corballis MC, 2007, AM SCI, V95, P240
Cornell Drucilla, 1992, DECONSTRUCTION POSSI, P68
de Bergerac Cyrano, 1970, VOYAGE LUNE AUTRE MO
De Graef Ortwin, 1998, ETHICAL PERSPECTIVES, V5, P15, DOI 10.2143/EP.5.1.563102
Derrida Jacques, 1972, MARGES PHILOS, P365
Draaisma D, 2009, PHILOS T R SOC B, V364, P1475, DOI 10.1098/rstb.2008.0324
Duffy Carol Ann, 2005, RAPTURE, P60
Frankfurt H. J., 1988, IMPORTANCE WHAT WE C
Gallese Vittorio, 2010, CALIFORNIA ITALIAN S, V2, P1
Hacking I, 2009, DAEDALUS-US, V138, P44, DOI 10.1162/daed.2009.138.3.44
Harvey Howard G., 1950, SYMPOSIUM, V4, P120
Hauser MD, 2002, SCIENCE, V298, P1569, DOI 10.1126/science.298.5598.1569
Kennedy A.L., 1996, SO I AM GLAD
Luhmann Niklas, 1998, LIEBE ALS PASSION CO
Luhmann Niklas, 1986, LOVE PASSION CODIFIC
Murdoch Iris, 2002, UNDER THE NET
Nietzsche Friedrich, 2009, GOOD EVIL
Osteen M, 2008, ROUTL RES CULT MEDIA, P1
PERKINS D, 1996, MOD LANG QUART, V57, P425
Romanowski S, 1998, SCI-FICTION STUD, V25, P414
Ruoff Gene W, 1989, WORDSWORTH COLERIDGE
Schecter Stephen, 2011, CANADIAN J SOCIOLOGY, V36, P388
Stirling Kirsten, 2006, ETHICALLY SPEAKING V, P37
Wolfe C., 2010, WHAT IS POSTHUMANISM
Wordsworth William, 1979, PRELUDE 1799 1805 18
NR 32
TC 0
Z9 0
PU HEBREW UNIV MAGNES PRESS
PI JERUSALEM
PA PO BOX 39099, JERUSALEM 91390, ISRAEL
SN 1565-3668
EI 1936-9247
J9 PARTIAL ANSW
JI Partial Answ.
PD JUN
PY 2014
VL 12
IS 2
BP 355
EP 374
PG 20
WC Literary Theory & Criticism
SC Literature
GA CB4FO
UT WOS:000349583800009
ER
PT J
AU Nakai, Y
Takashima, R
Takiguchi, T
Takada, S
AF Nakai, Yasushi
Takashima, Ryoichi
Takiguchi, Tetsuya
Takada, Satoshi
TI Speech intonation in children with autism spectrum disorder
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Autism spectrum disorder; Intonation; Acoustic analysis; Pitch;
Coefficient of variation; ASQ
ID HIGH-FUNCTIONING AUTISM; PROSODY; QUESTIONNAIRE; SPEAKERS; MELODY; PITCH
AB Objective: The prosody of children with autism spectrum disorder (ASD) has several abnormal features. We assessed the speech tone of children with ASD and of children with typical development (TD) by using a new quantitative acoustic analysis. Methods: Our study participants consisted of 63 children (26 with ASD and 37 with TD). The participants were divided into 4 groups based on their developmental features and age. We assessed the variety of the fundamental frequency (F0) pattern quantitatively, using pitch coefficient of variation (CV), considering the different F0 mean for each word. Results: (1) No significant difference was observed between the ASD and TD group at pre-school age. However, the TD group exhibited significantly greater pitch CV than the ASD group at school age. (2) In pitch CV, range and standard deviation of the whole speech of each participant, no significant differences were observed between the type of participants and age. (3) No significant correlation was found between the pitch CV of each word and the Japanese Autism Screening Questionnaire total score, or between the pitch CV of each word and the intelligence quotient levels in the ASD group. A significant correlation was observed between the pitch CV of each word and social reciprocal interaction score. Conclusions: We assessed the speech tone of children with ASD by using a new quantitative method. Monotonous speech in school-aged children with ASD was detected. The extent of monotonous speech was related to the extent of social reciprocal interaction in children with ASD. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Nakai, Yasushi; Takada, Satoshi] Kobe Univ, Grad Sch Hlth Sci, Kobe, Hyogo 657, Japan.
[Nakai, Yasushi] Kawasaki Coll Allied Hlth Profess, Dept Nursing Childcare, Kurashiki, Okayama 7010194, Japan.
[Takashima, Ryoichi; Takiguchi, Tetsuya] Kobe Univ, Grad Sch Syst Informat, Kobe, Hyogo 657, Japan.
RP Nakai, Y (reprint author), Kawasaki Coll Allied Hlth Profess, Dept Nursing Childcare, 316 Matsushima, Kurashiki, Okayama 7010194, Japan.
EM nakai@jc.kawasaki-m.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology
[21700565]
FX This study was supported by the Ministry of Education, Culture, Sports,
Science and Technology (21700565).
CR [American psychiatric association (APA) APA], 2000, DIAGN STAT MAN MENT, P69
Bonneh YS, 2011, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00237
Chevallier C, 2011, NEUROPSYCHOLOGIA, V49, P507, DOI 10.1016/j.neuropsychologia.2010.11.042
CRUTTENDEN A, 1981, J LINGUIST, V17, P77, DOI 10.1017/S0022226700006782
Cruttenden Alan, 1997, INTONATION, V2nd
Crystal D, 1979, STUDIES 1 LANGUAGE D, P174
Dairoku H, 2004, STUDIES ED CHILDREN, V7, P19
Diehl JJ, 2009, APPL PSYCHOLINGUIST, V30, P385, DOI 10.1017/S0142716409090201
Fechner GT, 1860, ELEMENTE PSYCHOPHYSI
Garnett MS, 1998, ASPERGERS SYNDROME G, P16
Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
Hesling I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011571
KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
KANNER L, 1971, J AUTISM CHILD SCHIZ, V1, P119, DOI 10.1007/BF01537953
Kent RD, 1996, AM J SPEECH-LANG PAT, V5, P7, DOI DOI 10.1044/1058-0360.0503.07
Koonrinshokenkyukai, 2010, JAPANESE ARTICULATIO
Nakai A, 2011, RES DEV DISABIL, V32, P1615, DOI 10.1016/j.ridd.2011.02.012
Paul R, 2005, J AUTISM DEV DISORD, V35, P861, DOI 10.1007/s10803-005-0031-8
Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
Russo NM, 2008, CLIN NEUROPHYSIOL, V119, P1720, DOI 10.1016/j.clinph.2008.01.108
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Sharda M, 2010, NEUROSCI LETT, V478, P42, DOI 10.1016/j.neulet.2010.04.066
Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
Snow D, 2002, INFANT BEHAV DEV, V24, P393
Snow D, 1998, J SPEECH LANG HEAR R, V41, P576
Snow D, 2002, LINGUA, V112, P1025, DOI 10.1016/S0024-3841(02)00060-8
TAGERFLUSBERG H, 1981, J AUTISM DEV DISORD, V11, P45, DOI 10.1007/BF01531340
Tager-Flusberg H, 1989, AUTISM NATURE DIAGNO, P92
Wilson BN, 2009, PHYS OCCUP THER PEDI, V29, P182, DOI 10.1080/01942630902784761
NR 30
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
EI 1872-7131
J9 BRAIN DEV-JPN
JI Brain Dev.
PD JUN
PY 2014
VL 36
IS 6
BP 516
EP 522
DI 10.1016/j.braindev.2013.07.006
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA CB2AJ
UT WOS:000349428800009
PM 23973369
ER
PT J
AU Slessor, G
Bailey, PE
Rendell, PG
Ruffman, T
Henry, JD
Miles, LK
AF Slessor, Gillian
Bailey, Phoebe E.
Rendell, Peter G.
Ruffman, Ted
Henry, Julie D.
Miles, Lynden K.
TI Examining the Time Course of Young and Older Adults' Mimicry of
Enjoyment and Nonenjoyment Smiles
SO EMOTION
LA English
DT Article
DE electromyography; facial expression mimicry; aging; smiles
ID EMOTIONAL FACIAL EXPRESSIONS; AGE-RELATED DIFFERENCES; ELECTROMYOGRAPHIC
RESPONSES; DETECTING HAPPINESS; SOCIAL-INTERACTION; DUCHENNE SMILES;
RECOGNITION; AUTISM; FACES; PERCEPTION
AB Electromyographic (EMG) research suggests that implicit mimicry of happy facial expressions remains intact with age. However, age-related differences in EMG responses to enjoyment and nonenjoyment smiles have not been explored. The present study assessed younger and older adults' orbicularis oculi (O.oculi; eye) and zygomaticus major (Z.major; cheek) reactions to images of individuals displaying enjoyment and nonenjoyment smiles. Both age groups mimicked displays of enjoyment smiles, and there were no age differences in O.oculi and Z.major activity to these expressions. However, compared with younger participants, older adults showed extended O.oculi activity to nonenjoyment smiles. In an explicit ratings task, older adults were also more likely than younger participants to attribute feelings of happiness to individuals displaying both nonenjoyment and enjoyment smiles. However, participants' ratings of the happiness expressed in images of enjoyment and nonenjoyment smiles were independent of their O.oculi responding to these expressions, suggesting that mimicry and emotion recognition may reflect separate processes. Potential mechanisms underlying these findings, as well as implications for social affiliation in older adulthood, are considered.
C1 [Slessor, Gillian; Miles, Lynden K.] Univ Aberdeen, Sch Psychol, Aberdeen AB24 2UB, Scotland.
[Bailey, Phoebe E.] Univ Western Sydney, Sch Social Sci & Psychol, Sydney, NSW, Australia.
[Bailey, Phoebe E.; Henry, Julie D.] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
[Rendell, Peter G.] Australian Catholic Univ, Sch Psychol, Sydney, NSW 2059, Australia.
[Ruffman, Ted] Univ Otago, Dept Psychol, Dunedin, New Zealand.
[Henry, Julie D.] Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
RP Slessor, G (reprint author), Univ Aberdeen, Sch Psychol, Coll Life Sci & Med, William Guild Bldg, Aberdeen AB24 2UB, Scotland.
EM g.slessor@abdn.ac.uk
RI Miles, Lynden/C-5168-2008
OI Miles, Lynden/0000-0002-4164-3470
CR Bailey PE, 2012, NEUROPSYCHOLOGIA, V50, P1632, DOI 10.1016/j.neuropsychologia.2012.03.017
Bailey PE, 2009, PSYCHOL AGING, V24, P224, DOI 10.1037/a0014112
Bailey PE, 2009, PSYCHOL AGING, V24, P995, DOI 10.1037/a0015789
Bailey PE, 2008, J GERONTOL B-PSYCHOL, V63, pP219
BALDWIN DA, 1993, DEV PSYCHOL, V29, P832, DOI 10.1037/0012-1649.29.5.832
Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
Blairy S, 1999, J NONVERBAL BEHAV, V23, P5, DOI 10.1023/A:1021370825283
Blampied M, 2010, BRIT J DEV PSYCHOL, V28, P483, DOI 10.1348/026151009X467621
Bogart KR, 2010, SOC NEUROSCI-UK, V5, P241, DOI 10.1080/17470910903395692
Boraston ZL, 2008, J AUTISM DEV DISORD, V38, P574, DOI 10.1007/s10803-007-0421-1
Bourgeois P, 2008, BIOL PSYCHOL, V77, P343, DOI 10.1016/j.biopsycho.2007.11.008
Butler KM, 2006, PSYCHOL AGING, V21, P638, DOI 10.1037/0882-7974.21.3.638
Carstensen LL, 1999, AM PSYCHOL, V54, P165, DOI 10.1037//0003-066X.54.3.165
Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893
Decety Jean, 2004, Behav Cogn Neurosci Rev, V3, P71, DOI 10.1177/1534582304267187
Dimberg U, 2000, PSYCHOPHYSIOLOGY, V37, P693, DOI 10.1017/S0048577200990759
Dimberg U, 2002, COGNITION EMOTION, V16, P449, DOI 10.1080/02699930143000356
Dimberg U, 2000, PSYCHOL SCI, V11, P86, DOI 10.1111/1467-9280.00221
Dimberg U, 1998, SCAND J PSYCHOL, V39, P39, DOI 10.1111/1467-9450.00054
Ebner NC, 2009, EMOTION, V9, P329, DOI 10.1037/a0015179
Ekman P., 2002, FACIAL ACTION CODING
Ekman P., 2001, TELLING LIES CLUES D
Frankel ML, 2002, ELECTRON J DIFFER EQ
FRANK MG, 1993, J PERS SOC PSYCHOL, V64, P83, DOI 10.1037/0022-3514.64.1.83
FRIDLUND AJ, 1986, PSYCHOPHYSIOLOGY, V23, P567, DOI 10.1111/j.1469-8986.1986.tb00676.x
Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
Goldman AI, 2005, COGNITION, V94, P193, DOI 10.1016/j.cognition.2004.01.005
Halberstadt J, 2011, PSYCHOL AGING, V26, P133, DOI 10.1037/a0021366
Hamilton AFDC, 2008, Q J EXP PSYCHOL, V61, P101, DOI 10.1080/17470210701508798
Hatfield E., 1992, PRIMITIVE EMOTIONAL, P151
Henry JD, 2009, PSYCHOL AGING, V24, P239, DOI 10.1037/a0013423
Hess U., 2009, METHODS SOCIAL NEURO, P70
Hess U, 2001, INT J PSYCHOPHYSIOL, V40, P129, DOI 10.1016/S0167-8760(00)00161-6
Hietanen JK, 1998, PSYCHOPHYSIOLOGY, V35, P530, DOI 10.1017/S0048577298970445
Isaacowitz DM, 2011, J NONVERBAL BEHAV, V35, P261, DOI 10.1007/s10919-011-0113-6
Johnston L, 2010, BRIT J SOC PSYCHOL, V49, P107, DOI 10.1348/014466609X412476
Krumhuber E, 2007, EMOTION, V7, P730, DOI 10.1037/1528-3542.7.4.730
Krumhuber EG, 2009, EMOTION, V9, P807, DOI 10.1037/a0017844
Magnee MJCM, 2007, NEUROREPORT, V18, P369, DOI 10.1097/WNR.0b013e32801776e6
Maringer M, 2011, EMOTION, V11, P181, DOI 10.1037/a0022596
Mather M, 2006, J GERONTOL B-PSYCHOL, V61, pP54
Mathuranath PS, 2000, NEUROLOGY, V55, P1613
Miles L, 2007, J NONVERBAL BEHAV, V31, P259, DOI 10.1007/s10919-007-0036-4
Moody EJ, 2007, EMOTION, V7, P447, DOI 10.1037/1528-3542.7.2.447
Murphy NA, 2010, PSYCHOL AGING, V25, P811, DOI 10.1037/a0019888
NATALE M, 1978, PSYCHOTHER-THEOR RES, V15, P145, DOI 10.1037/h0085854
Niedenthal PM, 2005, PERS SOC PSYCHOL REV, V9, P184, DOI 10.1207/s15327957pspr0903_1
Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
Oberman LM, 2007, SOC NEUROSCI, V2, P167, DOI 10.1080/17470910701391943
Owren MJ, 2001, EMO SOC BEH, P152
Phillips LH, 2011, J NONVERBAL BEHAV, V35, P279, DOI 10.1007/s10919-011-0114-5
Rousselet GA, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-114
Ruffman T, 2012, PSYCHOL AGING, V27, P543, DOI 10.1037/a0023380
Ruffman T, 2010, PSYCHOL AGING, V25, P492, DOI 10.1037/a0018247
Rymarczyk K, 2011, INT J PSYCHOPHYSIOL, V79, P330, DOI 10.1016/j.ijpsycho.2010.11.001
Salthouse TA, 1996, PSYCHOL REV, V103, P403, DOI 10.1037/0033-295X.103.3.403
Sato W, 2008, INT J PSYCHOPHYSIOL, V70, P70, DOI 10.1016/j.ijpsycho.2008.06.001
Schmidt KL, 2006, J NONVERBAL BEHAV, V30, P37, DOI 10.1007/s10919-005-0003-x
Slessor G, 2010, PSYCHOL AGING, V25, P246, DOI 10.1037/a0018248
Stanley JT, 2008, PSYCHOL AGING, V23, P24, DOI 10.1037/0882-7974.23.1.24
Sullivan S, 2004, BRIT J PSYCHOL, V95, P1, DOI 10.1348/000712604322779424
Surakka V, 1998, INT J PSYCHOPHYSIOL, V29, P23, DOI 10.1016/S0167-8760(97)00088-3
Tassinary L. G., 2000, HDB PSYCHOPHYSIOLOGY, P163
Tomasello M., 1999, CULTURAL ORIGINS HUM
van Baaren RB, 2004, PSYCHOL SCI, V15, P71, DOI 10.1111/j.0963-7214.2004.01501012.x
Welkowitz J., 1970, P 78 ANN CONV AM PSY, V5, P387, DOI 10.1037/h0035328
ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 67
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1528-3542
EI 1931-1516
J9 EMOTION
JI Emotion
PD JUN
PY 2014
VL 14
IS 3
BP 532
EP 544
DI 10.1037/a0035825
PG 13
WC Psychology, Experimental
SC Psychology
GA CA8KT
UT WOS:000349169700011
PM 24798677
ER
PT J
AU Moons, WG
Way, BM
Taylor, SE
AF Moons, Wesley G.
Way, Baldwin M.
Taylor, Shelley E.
TI Oxytocin and Vasopressin Receptor Polymorphisms Interact With
Circulating Neuropeptides to Predict Human Emotional Reactions to Stress
SO EMOTION
LA English
DT Article
DE OXTR rs53576; oxytocin; AVPR1A RS1; vasopressin; emotion
ID AUTISM SPECTRUM DISORDERS; HAMSTERS MESOCRICETUS-AURATUS; ADRENAL AXIS
RESPONSES; SOCIAL-BEHAVIOR; ARGININE-VASOPRESSIN; AGGRESSIVE-BEHAVIOR;
GENE OXTR; PSYCHOSOCIAL STRESS; LACTATING WOMEN; GOLDEN-HAMSTERS
AB Oxytocin (OT) and a polymorphism (rs53576) in the oxytocin receptor gene (OXTR) have been independently associated with stress reactivity, whereas oxytocin's sister peptide, arginine vasopressin (AVP) and polymorphisms in the vasopressin receptor gene (AVPR1A) have been independently associated with aggressive behavior. In this study, 68 men and 98 women were genotyped for the OXTR rs53576 polymorphism and the AVPR1A RS1 polymorphism. Baseline and poststressor levels of plasma OT, plasma AVP, positive affect, and anger were assessed. Women, but not men, with high levels of poststressor OT and the GG genotype of rs53576 felt the most positive affect after the stressor. Men, but not women, with high levels of poststressor AVP and the 320 allele of the RS1 polymorphism reported more poststressor anger than noncarriers. These data constitute the first evidence that oxytocin and vasopressin receptor genes interact with levels of OT and AVP to predict sex-specific emotional stress responses.
C1 [Moons, Wesley G.] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA.
[Way, Baldwin M.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[Taylor, Shelley E.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA.
RP Moons, WG (reprint author), Univ Calif Davis, Dept Psychol, 1 Shields Ave, Davis, CA 95616 USA.
EM wgmoons@ucdavis.edu
CR Albers HE, 1998, PROG BRAIN RES, V119, P395
ALTEMUS M, 1995, J CLIN ENDOCR METAB, V80, P2954, DOI 10.1210/jc.80.10.2954
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
AVERILL JR, 1983, AM PSYCHOL, V38, P1145, DOI 10.1037/0003-066X.38.11.1145
Bachner-Melman R, 2005, PLOS GENET, V1, P394, DOI 10.1371/journal.pgen.0010042
Bakermans-Kranenburg MJ, 2008, SOC COGN AFFECT NEUR, V3, P128, DOI 10.1093/scan/nsn004
Bartz JA, 2008, PROG BRAIN RES, V170, P451, DOI 10.1016/S0079-6123(08)00435-4
Brown CH, 2013, J NEUROENDOCRINOL, V25, P678, DOI 10.1111/jne.12051
BROWNSTEIN MJ, 1980, SCIENCE, V207, P373, DOI 10.1126/science.6153132
Carter CS, 1997, ANN NY ACAD SCI, V807, P164, DOI 10.1111/j.1749-6632.1997.tb51918.x
Carter CS, 2009, DEV NEUROSCI-BASEL, V31, P332, DOI 10.1159/000216544
Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025
Carver CS, 1997, INT J BEHAV MED, V4, P92, DOI 10.1207/s15327558ijbm0401_6
Carver CS, 2009, PSYCHOL BULL, V135, P183, DOI 10.1037/a0013965
Chen FS, 2011, P NATL ACAD SCI USA, V108, P19937, DOI 10.1073/pnas.1113079108
Choleris E, 2003, P NATL ACAD SCI USA, V100, P6192, DOI 10.1073/pnas.0631699100
Coccaro EF, 1998, HARVARD REV PSYCHIAT, V5, P336, DOI 10.3109/10673229809003583
de Oliveira DCG, 2012, J PSYCHOPHARMACOL, V26, P497, DOI 10.1177/0269881111400642
DeVries AC, 1996, P NATL ACAD SCI USA, V93, P11980, DOI 10.1073/pnas.93.21.11980
de Vries GJ, 2008, PROG BRAIN RES, V170, P17, DOI 10.1016/S0079-6123(08)00402-0
Ebner K, 2005, HORM BEHAV, V47, P14, DOI 10.1016/j.bhbeh.2004.08.002
Ebstein RP, 2009, ANN NY ACAD SCI, V1167, P87, DOI 10.1111/j.1749-6632.2009.04541.x
Engelmann M, 1999, J NEUROENDOCRINOL, V11, P867
Excoffier L, 2010, MOL ECOL RESOUR, V10, P564, DOI 10.1111/j.1755-0998.2010.02847.x
Feder A, 2009, NAT REV NEUROSCI, V10, P446, DOI 10.1038/nrn2649
Feldman R, 2007, PSYCHOL SCI, V18, P965, DOI 10.1111/j.1467-9280.2007.02010.x
Ferris CF, 1997, J NEUROSCI, V17, P4331
Ferris CF, 2000, EXP PHYSIOL, V85, p85S, DOI 10.1111/j.1469-445X.2000.tb00011.x
Ferris CF, 1999, BEHAV NEUROSCI, V113, P804, DOI 10.1037/0735-7044.113.4.804
Ferris CF, 2006, PHARMACOL BIOCHEM BE, V83, P169, DOI 10.1016/j.pbb.2006.01.001
Gabor CS, 2012, BEHAV NEUROSCI, V126, P97, DOI 10.1037/a0026464
Gamer M, 2010, P NATL ACAD SCI USA, V107, P9400, DOI 10.1073/pnas.1000985107
Gimpl G, 2001, PHYSIOL REV, V81, P629
Goodson JL, 2001, BRAIN RES REV, V35, P246, DOI 10.1016/S0165-0173(01)00043-1
Grewen KM, 2005, PSYCHOSOM MED, V67, P531, DOI 10.1097/01.psy.0000170341.88395.47
Harmon-Jones E, 1998, J PERS SOC PSYCHOL, V74, P1310, DOI 10.1037//0022-3514.74.5.1310
Heinrichs M, 2001, J CLIN ENDOCR METAB, V86, P4798, DOI 10.1210/jc.86.10.4798
Heinrichs M, 2003, BIOL PSYCHIAT, V54, P1389, DOI 10.1016/S0006-3223(03)00465-7
Heinrichs M, 2008, PROG BRAIN RES, V170, P337, DOI 10.1016/S0079-6123(08)00428-7
Kim HS, 2011, SOC PSYCHOL PERS SCI, V2, P665, DOI 10.1177/1948550611405854
Kim HS, 2010, P NATL ACAD SCI USA, V107, P15717, DOI 10.1073/pnas.1010830107
Kim SJ, 2002, MOL PSYCHIATR, V7, P503, DOI 10.1038/sj.mp.4001125
KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
Knobloch HS, 2012, NEURON, V73, P553, DOI 10.1016/j.neuron.2011.11.030
Lazarus R. S., 1984, STRESS APPRAISAL COP
Leng G, 2008, J PHYSIOL-LONDON, V586, P5625, DOI 10.1113/jphysiol.2008.159103
Levin R, 2009, PSYCHONEUROENDOCRINO, V34, P901, DOI 10.1016/j.psyneuen.2008.12.014
Light KC, 2005, BIOL PSYCHOL, V69, P5, DOI 10.1016/j.biopsycho.2004.11.002
Lucht MJ, 2009, PROG NEURO-PSYCHOPH, V33, P860, DOI 10.1016/j.pnpbp.2009.04.004
Ludwig M, 2006, NAT REV NEUROSCI, V7, P126, DOI 10.1038/nrn1845
Ludwig M, 1995, NEUROENDOCRINOLOGY, V62, P619, DOI 10.1159/000127058
Marsh AA, 2012, PSYCHOPHARMACOLOGY, V224, P469, DOI 10.1007/s00213-012-2775-0
Meyer-Lindenberg A., 2008, MOL PSYCHIATR, V14, P968, DOI 10.1038/mp.2008.54
Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
Mezzacappa ES, 2002, HEALTH PSYCHOL, V21, P187, DOI 10.1037//0278-6133.21.2.187
Mezzacappa ES, 2004, NUTR REV, V62, P261, DOI 10.1111/j.1753-4887.2004.tb00050.x
Miller M, 2013, AUTISM RES, V6, P91, DOI 10.1002/aur.1270
Mogil JS, 2011, NAT NEUROSCI, V14, P1569, DOI 10.1038/nn.2941
Mogil JS, 2010, PROG BRAIN RES, V186, P141, DOI 10.1016/B978-0-444-53630-3.00009-9
Moons WG, 2010, BRAIN BEHAV IMMUN, V24, P215, DOI 10.1016/j.bbi.2009.08.009
Mueller KL, 2007, J IMMUNOL, V179, P3559
Neumann ID, 2012, TRENDS NEUROSCI, V35, P649, DOI 10.1016/j.tins.2012.08.004
Nikolova YS, 2012, BIOL PSYCHIAT, V72, P157, DOI 10.1016/j.biopsych.2012.03.014
Nishioka T, 1998, BRAIN RES, V781, P57, DOI 10.1016/S0006-8993(97)01159-1
Pavlov KA, 2012, J APPL GENET, V53, P61, DOI 10.1007/s13353-011-0069-6
Riem MME, 2011, SOC COGN AFFECT NEUR, V6, P294, DOI 10.1093/scan/nsq035
Rodrigues SM, 2009, P NATL ACAD SCI USA, V106, P21437, DOI 10.1073/pnas.0909579106
Ross HE, 2009, NEUROSCIENCE, V162, P892, DOI 10.1016/j.neuroscience.2009.05.055
RUSSELL D, 1980, J PERS SOC PSYCHOL, V39, P472, DOI 10.1037/0022-3514.39.3.472
Saphire-Bernstein S, 2011, P NATL ACAD SCI USA, V108, P15118, DOI 10.1073/pnas.1113137108
Shalev I, 2011, HORM BEHAV, V60, P121, DOI 10.1016/j.yhbeh.2011.04.005
Sicard MN, 2010, PHARMACOGENOMICS, V11, P1561, DOI [10.2217/pgs.10.123, 10.2217/PGS.10.123]
SMITH CA, 1985, J PERS SOC PSYCHOL, V48, P813, DOI 10.1037//0022-3514.48.4.813
Striepens N, 2011, FRONT NEUROENDOCRIN, V32, P426, DOI 10.1016/j.yfrne.2011.07.001
SWAAB DF, 1975, J NEURAL TRANSM, V36, P195, DOI 10.1007/BF01253126
Tabak BA, 2011, PSYCHONEUROENDOCRINO, V36, P115, DOI 10.1016/j.psyneuen.2010.07.004
Tansey KE, 2010, NEUROSCI LETT, V474, P163, DOI 10.1016/j.neulet.2010.03.035
Tansey KE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-3
Taylor SE, 2010, PSYCHOL SCI, V21, P3, DOI 10.1177/0956797609356507
Taylor SE, 2006, PSYCHOSOM MED, V68, P238, DOI 10.1097/01.psy.0000203242.95990.74
Thompson R, 2004, PSYCHONEUROENDOCRINO, V29, P35, DOI 10.1016/S0306-4530(02)00133-6
Thompson RR, 2006, P NATL ACAD SCI USA, V103, P7889, DOI 10.1073/pnas.0600406103
Tomaka J, 1997, J PERS SOC PSYCHOL, V73, P63, DOI 10.1037/0022-3514.73.1.63
Tost H, 2010, P NATL ACAD SCI USA, V107, P13936, DOI 10.1073/pnas.1003296107
Uvnas-Moberg K, 2005, INT J BEHAV MED, V12, P59, DOI 10.1207/s15327558ijbm1202_3
UVNASMOBERG K, 1990, J PSYCHOSOM OBST GYN, V11, P261, DOI 10.3109/01674829009084422
Uvnas-Moberg K, 2001, APPL ANIM BEHAV SCI, V72, P225, DOI 10.1016/S0168-1591(01)00112-5
VANDESANDE F, 1975, CELL TISSUE RES, V164, P153
Yamasue H, 2009, PSYCHIAT CLIN NEUROS, V63, P129, DOI 10.1111/j.1440-1819.2009.01944.x
Yirmiya N, 2006, MOL PSYCHIATR, V11, P488, DOI 10.1038/sj.mp.4001812
Zak PJ, 2005, HORM BEHAV, V48, P522, DOI 10.1016/j.yhbeh.2005.07.009
Zhang JP, 2010, AM J PSYCHIAT, V167, P763, DOI 10.1176/appi.ajp.2009.09040598
NR 92
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1528-3542
EI 1931-1516
J9 EMOTION
JI Emotion
PD JUN
PY 2014
VL 14
IS 3
BP 562
EP 572
DI 10.1037/a0035503
PG 11
WC Psychology, Experimental
SC Psychology
GA CA8KT
UT WOS:000349169700013
PM 24660771
ER
PT J
AU Ottley, JR
Hanline, MF
AF Ottley, Jennifer Riggie
Hanline, Mary Frances
TI Bug-in-Ear Coaching: Impacts on Early Childhood Educators' Practices and
Associations With Toddlers' Expressive Communication
SO JOURNAL OF EARLY INTERVENTION
LA English
DT Article
DE professional development; bug-in-ear; audio coaching; technology;
inclusion; language and communication; single-case methods
ID AUTISM SPECTRUM DISORDERS; INTERVENTION PRACTICES; INTERACTION SKILLS;
TEACHER-EDUCATION; CHILDREN; DISABILITIES; PRESCHOOL; SETTINGS; MOTHER;
REINFORCEMENT
AB Many early childhood educators struggle to meet the communication needs of children with delays and disabilities. The purpose of this study was to examine the functional relation between bug-in-ear coaching and the frequency of educators' correct use of targeted communication strategies, as well as associations with children's expressive communication. Four multiple-baseline single-case intervention design experiments were completed. Dependent variables were educators' use of communication strategies and the expressive communication of children with delays or disabilities. Bug-in-ear improved educators' implementation of at least one communication strategy for each educator. Effect sizes were large for three educators and moderate for one. Each behavior successfully implemented during intervention was maintained at moderate levels or better, while behaviors implemented with greater variability during intervention were not maintained. Associations with children's expressive communication were questionable/small during both intervention and maintenance. Outcomes suggest that bug-in-ear is a socially valid practice that shows promise of effectiveness in inclusive early childhood environments. Implications and future directions are provided.
C1 [Ottley, Jennifer Riggie; Hanline, Mary Frances] Florida State Univ, Tallahassee, FL 32306 USA.
[Ottley, Jennifer Riggie] Ohio State Univ, Columbus, OH 43201 USA.
RP Ottley, JR (reprint author), Ohio State Univ, Crane Ctr Early Childhood Res & Policy, 175 East Seventh Ave, Columbus, OH 43201 USA.
EM ottley.2@osu.edu
CR Bowles E. P., 1976, J SCH PSYCHOL, V14, P15
Brown C. S., 2010, THESIS
Chang F, 2005, J EARLY INTERVENTION, V27, P110, DOI 10.1177/105381510502700206
Clawson C, 2008, TOP EARLY CHILD SPEC, V28, P132, DOI 10.1177/0271121407311482
CRIMMINS DB, 1984, CHILD ABUSE NEGLECT, V8, P533, DOI 10.1016/0145-2134(84)90036-X
Daugherty S, 2001, TOP EARLY CHILD SPEC, V21, P213, DOI 10.1177/027112140102100402
Delaney E. M., 2001, BEHAV DISORDERS, V26, P91
Diamond K. E., 2013, 20133001 NCSER US DE
Diamond KE, 2011, J EARLY INTERVENTION, V33, P75, DOI 10.1177/1053815111400416
Division for Early Childhood & National Association for the Education of Young Children, 2009, EARL CHILDH INCL JOI
Giebelhaus C. R., 1995, IMPLEMENTING BIE INT
GIEBELHAUS CR, 1994, J TEACH EDUC, V45, P365, DOI 10.1177/0022487194045005009
Goodman JI, 2008, FOCUS AUTISM DEV DIS, V23, P207, DOI 10.1177/1088357608324713
Greenwood CR, 2010, J EARLY INTERVENTION, V32, P310, DOI 10.1177/1053815110392335
Hanley GP, 2009, J APPL BEHAV ANAL, V42, P33, DOI 10.1901/jaba.2009.42-33
Hattie J, 2007, REV EDUC RES, V77, P81, DOI 10.3102/003465430298487
Hawkins S. R., 2008, THESIS
HEROLD PL, 1971, EDUC TECHNOL, V11, P30
Hintze JL, 2007, NUMBER CRUNCHER STAT
Horn E, 2000, TOP EARLY CHILD SPEC, V20, P208, DOI 10.1177/027112140002000402
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Ingersoll B, 2006, J POSIT BEHAV INTERV, V8, P79, DOI 10.1177/10983007060080020601
Kahan D, 2002, J TEACH PHYS EDUC, V22, P86
Kashinath S., 2002, THESIS
KOGAN KL, 1975, CHILD PSYCHIAT HUM D, V5, P189, DOI 10.1007/BF01433679
Kohler FW, 2001, TOP EARLY CHILD SPEC, V21, P93, DOI 10.1177/027112140102100203
Komiskey C. A., 2004, THESIS
Korner I., 1962, J CONSULT PSYCHOL, V16, P81
Kratochwill T. R., 2010, SINGLE CASE DESIGN T
Kratochwill TR, 2010, PSYCHOL METHODS, V15, P124, DOI 10.1037/a0017736
Leach D., 2007, THESIS
Lee D. L., 2006, TEACH EDUC SPEC EDUC, V29, P12, DOI [10.1177/088840640602900103, DOI 10.1177/088840640602900103]
Lindell L., 2001, THESIS
Luze GJ, 2001, SCHOOL PSYCHOL REV, V30, P383
Macy M. G., 2007, EARLY CHILD DEV CARE, V177, P107, DOI [10.1080/03004430500337265, DOI 10.1080/03004430500337265]
McWilliam R. A., 2003, EARLY EDUC DEV, V14, P7, DOI DOI 10.1207/S15566935EED1401_2
Mobayed K., 2000, J EARLY INTERVENTION, V23, P165, DOI DOI 10.1177/10538151000230030601
Odluyurt S, 2010, KURAM UYGULAMA EGI, V10, P1563
Odom SL, 2009, TOP EARLY CHILD SPEC, V29, P53, DOI 10.1177/0271121408329171
Oliver P., 2008, THESIS
Parker RI, 2009, EXCEPT CHILDREN, V75, P135
Phelps D. L., 2013, THESIS
Pretti-Frontczak K., 2004, ACTIVITY BASED APPRO
Puliafico AC, 2013, COGN BEHAV PRACT, V20, P517
Raver CC, 2008, EARLY CHILD RES Q, V23, P10, DOI 10.1016/j.ecresq.2007.09.001
Rock M. L., 2009, TEACH EDUC SPEC EDUC, V32, P64, DOI [10.1177/0888406408330872, DOI 10.1177/0888406408330872]
Rock ML, 2014, TEACH EDUC SPEC EDUC, V37, P161, DOI 10.1177/0888406414525048
Scheeler M. C., 2012, TEACH EDUC SPEC EDUC, V35, P77, DOI DOI 10.1177/0888406411401919
Scheeler M. C., 2009, J BEHAV ED, V18, P189, DOI DOI 10.1007/S10864-009-9088-3
Scheeler M. C., 2002, J BEHAV ED, V11, P231, DOI [10.1023/A:1021158805714, DOI 10.1023/A:1021158805714]
Scheeler M. C., 2010, TEACHER ED SPECIAL E, V33, P83, DOI [10.1177/0888406409357013, DOI 10.1177/0888406409357013]
Scheeler MC, 2004, TEACH EDUC SPEC EDUC, V27, P396, DOI DOI 10.1177/088840640402700407
Schepis MM, 2001, J APPL BEHAV ANAL, V34, P313, DOI 10.1901/jaba.2001.34-313
Schertz HH, 2011, TOP EARLY CHILD SPEC, V31, P4, DOI 10.1177/0271121410382460
Schwartz IS, 1996, TOP EARLY CHILD SPEC, V16, P251
Sharpe T, 1997, RES Q EXERCISE SPORT, V68, P222
Tate T. L., 2005, ED TREATMENT CHILDRE, V28, P206
THOMSON CL, 1978, MONOGR SOC RES CHILD, V43, P1, DOI 10.2307/1165863
Trivette CM, 2010, TOP EARLY CHILD SPEC, V30, P3, DOI 10.1177/0271121410364250
Trivette C. M., 2009, EFFECTS DIFFERENT TY, V4
WARD CH, 1960, ARCH GEN PSYCHIAT, V3, P357
WIMBERGE.HC, 1974, ARCH GEN PSYCHIAT, V30, P636
Woods J, 2004, J EARLY INTERVENTION, V26, P175, DOI 10.1177/105381510402600302
Woods JJ, 2011, LANG SPEECH HEAR SER, V42, P379, DOI 10.1044/0161-1461(2011/10-0016)
Workgroup on Principles and Practices in Natural Environments, 2008, 7 KEY PRINC LOOKS C
NR 65
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1053-8151
EI 2154-3992
J9 J EARLY INTERVENTION
JI J. Early Interv.
PD JUN
PY 2014
VL 36
IS 2
BP 90
EP 110
DI 10.1177/1053815114563614
PG 21
WC Education, Special; Psychology, Educational; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AX4FT
UT WOS:000346889800002
ER
PT J
AU Appelman, M
Vail, CO
Lieberman-Betz, RG
AF Appelman, Michelle
Vail, Cynthia O.
Lieberman-Betz, Rebecca G.
TI The Effects of Constant Time Delay and Instructive Feedback on the
Acquisition of English and Spanish Sight Words
SO JOURNAL OF EARLY INTERVENTION
LA English
DT Article
DE constant time delay; instructive feedback; observational learning
ID SOCIAL VALIDATION; VALIDITY; CHILDREN; AUTISM
AB The authors of this study evaluated the acquisition of instructive feedback information presented to four kindergarten children with mild delays taught in dyads using a constant time delay (CTD) procedure. They also assessed the learning of observational (dyadic partner) information within this instructional arrangement. A multiple probe design across word sets, replicated across the four participants, was used to evaluate the efficacy of the CTD procedure and instructive feedback on the students' expressive English sight word identification, the corresponding Spanish translations, and other students' target words. Results showed that all participants acquired high percentages of their targeted English sight words, as well as targeted Spanish translations taught through an instructive feedback procedure. Lower percentages of non-targeted English and Spanish words were acquired through observational learning.
C1 [Appelman, Michelle; Vail, Cynthia O.; Lieberman-Betz, Rebecca G.] Univ Georgia, Athens, GA 30602 USA.
RP Vail, CO (reprint author), Univ Georgia, Dept Commun Sci & Special Educ, 570 Aderhold Hall, Athens, GA 30602 USA.
EM cvail@uga.edu
CR Alig-Cybriwsky C., 1990, J EARLY INTERVENTION, V14, P99
Anthony L., 1996, J BEHAV ED, V6, P111, DOI 10.1007/BF02110228
Delmolino L, 2013, RES AUTISM SPECT DIS, V7, P648, DOI 10.1016/j.rasd.2013.02.015
Gast D. L., 2010, SINGLE SUBJECT RES M, P57
Gast D. L., 1990, EXCEPTIONALITY, V1, P81
Gast D. L., 1994, J BEHAV ED, V4, P313, DOI 10.1007/BF01531985
Griffen AK, 1998, EDUC TRAIN MENT RET, V33, P42
Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
Holcombe A., 1993, J BEHAV ED, V3, P259, DOI 10.1007/BF00961555
Kaminski R. A., 2013, DYNAMIC INDICATORS B
KAZDIN AE, 1977, BEHAV MODIF, V1, P427, DOI 10.1177/014544557714001
Ledford JR, 2008, J AUTISM DEV DISORD, V38, P86, DOI 10.1007/s10803-007-0363-7
McCarney S. B., 2010, PRESCHOOL EVALUATION
Neitzel J., 2009, STEP IMPLEMENTATION
Reichow B, 2011, J APPL BEHAV ANAL, V44, P327, DOI 10.1901/jaba.2011.44-327
SCHOEN SF, 1995, J AUTISM DEV DISORD, V25, P503, DOI 10.1007/BF02178297
SCHWARTZ IS, 1991, J APPL BEHAV ANAL, V24, P189, DOI 10.1901/jaba.1991.24-189
Semel E., 2003, CLIN EVALUATION LANG, V4th
Shelton B. S., 1991, LANG SPEECH HEAR SER, V22, P123
STOREY K, 1991, J SPEC EDUC, V25, P352
US Census Bureau, 2012, STAT COUNT QUICKFACT
Voress J. K., 2012, DEV ASSESSMENT YOUNG
Werts M. G., 1993, EXCEPTIONALITY, V4, P81, DOI DOI 10.1207/S15327035EX0402_2
Werts M. G., 1995, J BEHAV ED, V5, P55, DOI 10.1007/BF02110214
Werts MG, 2003, J SPEC EDUC, V37, P124
Whalen C, 1996, EDUC TRAIN MENT RET, V31, P188
WOLERY M, 1992, RES DEV DISABIL, V13, P239, DOI 10.1016/0891-4222(92)90028-5
WOLF MM, 1978, J APPL BEHAV ANAL, V11, P203, DOI 10.1901/jaba.1978.11-203
Zimmerman I. L., 2011, PRESCHOOL LANGUAGE S
NR 29
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1053-8151
EI 2154-3992
J9 J EARLY INTERVENTION
JI J. Early Interv.
PD JUN
PY 2014
VL 36
IS 2
BP 131
EP 148
DI 10.1177/1053815114563613
PG 18
WC Education, Special; Psychology, Educational; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AX4FT
UT WOS:000346889800004
ER
PT J
AU van der Meer, L
Sigafoos, J
Sutherland, D
McLay, L
Lang, R
Lancioni, GE
O'Reilly, MF
Marschik, PB
AF van der Meer, Larah
Sigafoos, Jeff
Sutherland, Dean
McLay, Laurie
Lang, Russell
Lancioni, Giulio E.
O'Reilly, Mark F.
Marschik, Peter B.
TI Preference-Enhanced Communication Intervention and Development of Social
Communicative Functions in a Child With Autism Spectrum Disorder
SO CLINICAL CASE STUDIES
LA English
DT Article
DE augmentative and alternative communication; autism spectrum disorder;
iPad (R); preference; speech-generating devices
ID SPEECH-GENERATING DEVICES; ALTERNATIVE COMMUNICATION; PICTURE EXCHANGE;
LANGUAGE; DISABILITIES; PATHOLOGY; INDIVIDUALS; TECHNOLOGY; STUDENTS;
MODES
AB Individuals with autism spectrum disorder (ASD) who exhibit limited speech can learn to communicate using augmentative and alternative communication (AAC) systems. We describe the case of Ian, a 10-year-old boy with ASD who had learned to use an Apple iPod (R)- and iPad (R)-based speech-generating device (SGD)(Note 1), picture exchange (PE), and manual signing (MS) for functional communication (e.g., requesting), but had difficulty in using these AAC systems for spontaneous and socially oriented functions of communication. His difficulties were originally conceptualized as reflecting the social interaction and communication deficits characteristic of ASD. Alternatively, we suggest that the intervention did not allow for the development of more advanced communication. A preference-enhanced intervention was introduced with Ian's chosen AAC system only, that is the iPad (R)-based SGD. Opportunities for communication were created using highly motivating activities and behavioral strategies. Results suggest that the approach facilitated development of spontaneous and socially oriented communication.
C1 [van der Meer, Larah; Sigafoos, Jeff] Victoria Univ Wellington, Sch Educ Psychol, Wellington 6005, New Zealand.
[Sutherland, Dean; McLay, Laurie] Univ Canterbury, Sch Hlth Sci, Christchurch 1, New Zealand.
[Lang, Russell] Texas State Univ, Dept Curriculum & Instruct, San Marcos, TX USA.
[Lancioni, Giulio E.] Univ Bari, Dept Neurosci & Sense Organs, I-70121 Bari, Italy.
[O'Reilly, Mark F.] Univ Texas Austin, Coll Educ, Austin, TX 78712 USA.
[Marschik, Peter B.] Med Univ Graz, Inst Physiol, Graz, Austria.
[O'Reilly, Mark F.] Univ Texas Austin, Dept Special Educ, Austin, TX 78712 USA.
RP Sigafoos, J (reprint author), Victoria Univ Wellington, Sch Educ Psychol, POB 17-310,Karori 6147, Wellington 6005, New Zealand.
EM jeff.sigafoos@vuw.ac.nz
CR Abbott C., 2011, LEARNING DIFFERENCE
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
[Anonymous], 1992, INT STAT CLASS DIS R
Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x
Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Drager K., 2009, AUTISM SPECTRUM DISO, P247
Flippin M, 2010, AM J SPEECH-LANG PAT, V19, P178, DOI 10.1044/1058-0360(2010/09-0022)
Ganz JB, 2012, J AUTISM DEV DISORD, V42, P60, DOI 10.1007/s10803-011-1212-2
Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
Green V., 2008, EARLY CHILDHOOD ED I, P87
HALLE JW, 1979, J APPL BEHAV ANAL, V12, P431, DOI 10.1901/jaba.1979.12-431
Johnson JM, 2006, AUGMENT ALTERN COMM, V22, P85, DOI 10.1080/07434610500483588
Lancioni GE, 2007, RES DEV DISABIL, V28, P468, DOI 10.1016/j.ridd.2006.06.003
Matson JL, 2012, RES AUTISM SPECT DIS, V6, P573, DOI 10.1016/j.rasd.2011.10.009
McNaughton D, 2013, AUGMENT ALTERN COMM, V29, P107, DOI 10.3109/07434618.2013.784930
Mirenda P., 2013, AUGMENTATIVE ALTERNA, V4th
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
Osterling J., 2001, HDB CLIN CHILD PSYCH, P432
Paul R, 2013, J AUTISM DEV DISORD, V43, P418, DOI 10.1007/s10803-012-1583-z
Prizant B., 2005, HDB AUTISM PERVASIVE, V2, P925
Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
Ruggero L, 2012, INT J SPEECH-LANG PA, V14, P338, DOI [10.3109/17549507.2011.650213, 10.3109/17549507.2012.650213]
Shane HC, 2012, J AUTISM DEV DISORD, V42, P1228, DOI 10.1007/s10803-011-1304-z
Sigafoos J., 2007, AUTISM SPECTRUM DISO, P151
Sigafoos J, 2003, EFFICACY AUGMENTATIV, P323
Skinner B. F., 1957, VERBAL BEHAV
Sparrow S., 2005, VINELAND 2 ADAPTIVE, V2nd
Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091
Sturmey P., 2009, LANGUAGE AUTISM APPL, P3
TagerFlusberg H, 1996, J AUTISM DEV DISORD, V26, P169, DOI 10.1007/BF02172006
van der Meer L, 2013, AUGMENT ALTERN COMM, V29, P222, DOI 10.3109/07434618.2013.815801
van der Meer L, 2012, J DEV PHYS DISABIL, V24, P451, DOI 10.1007/s10882-012-9283-3
van der Meer L, 2012, RES AUTISM SPECT DIS, V6, P1247, DOI 10.1016/j.rasd.2012.04.005
van der Meer L, 2012, RES DEV DISABIL, V33, P1658, DOI 10.1016/j.ridd.2012.04.004
van der Meer LAJ, 2010, DEV NEUROREHABIL, V13, P294, DOI 10.3109/17518421003671494
Verdon S, 2011, INT J SPEECH-LANG PA, V13, P239, DOI 10.3109/17549507.2011.573865
Wendt O., 2009, AUTISM SPECTRUM DISO, P83
Wilkinson KM, 1998, MENT RETARD DEV D R, V4, P73, DOI 10.1002/(SICI)1098-2779(1998)4:2<73::AID-MRDD3>3.0.CO;2-Y
NR 40
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-6501
EI 1552-3802
J9 CLIN CASE STUD
JI Clin. Case Stud.
PD JUN
PY 2014
VL 13
IS 3
BP 282
EP 295
DI 10.1177/1534650113508221
PG 14
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AW9PG
UT WOS:000346588900006
ER
PT J
AU Milovancevic, MP
Tenjovic, L
Ispanovic, V
Mitkovic, M
Kircanski, JR
Mincic, T
Miletic, V
Gajic, SD
Tosevski, DL
AF Milovancevic, Milica Pejovic
Tenjovic, Lazar
Ispanovic, Veronika
Mitkovic, Marija
Kircanski, Jelena Radosavljev
Mincic, Teodora
Miletic, Vladimir
Gajic, Saveta Draganic
Tosevski, Dusica Lecic
TI Psychopathology and resilience in relation to abuse in childhood among
youth first referred to the psychiatrist
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE psychopathology; resilience, psychological; child abuse; adolescent
psyhiatry
ID CHILDREN; MECHANISMS; ASSOCIATIONS; MALTREATMENT; ADOLESCENTS; VIOLENCE;
AUTISM; HEALTH
AB Background/Aim. Child abuse may be related to adverse psychological outcomes in adult life. However, little is known about specific clinical, family and resilience profiles of adolescents that have experienced child abuse. The aim of this study was to investigate clinical symptoms, family functioning and resilience characteristics of adolescents with the experience of abuse, first referred to psychiatrists. Methods. The study included 84 young participants (mean age 14.90 +/- 3.10, ranging from 11 to 18 years) as consecutive first referrals to the Clinic for Children and Youth of the Institute of Mental Health, Belgrade, Serbia. The sample consisted of two groups, based on the Child Abuse Matrices of Risks. The first group included adolescents with the experience of abuse in childhood (n = 38, 13 males, 25 females), whereas the second, control group, comprised of non-abused adolescents (n = 47, 20 males, 27 females). The presence of abuse was evaluated by the Child Abuse Matrices of Risks. The study used the following questionnaires: Youth Self-Report (YSR), Adolescent Resilience Attitudes Scale (ARAS), and Self-Report Family Inventory (SFI). Results. Significant differences were found only among females. According to YSR, the abused girls had significantly higher scores on the Delinquent Behavior scale and marginally higher scores on Anxious/Depressed and Social Problems scales. Analyses of the SFI showed significantly lower family functioning among the girls with the child abuse history for all scales except for the Directive Leadership. The abused girls also showed significantly lower scores on the Insight scale, and marginally lower Initiative scores at the ARAS. Conclusions. These findings may have practical application in the creation of specific preventive and treatment strategies, particularly focused on delinquent tendencies, as well as on enhancing resilience through providing positive environments within families, schools and communities.
C1 [Milovancevic, Milica Pejovic; Gajic, Saveta Draganic; Tosevski, Dusica Lecic] Univ Belgrade, Fac Med, Belgrade, Serbia.
[Milovancevic, Milica Pejovic; Mitkovic, Marija; Kircanski, Jelena Radosavljev; Mincic, Teodora; Gajic, Saveta Draganic; Tosevski, Dusica Lecic] Inst Mental Hlth, Belgrade, Serbia.
[Tenjovic, Lazar] Univ Belgrade, Dept Psychol, Fac Philosophy, Belgrade, Serbia.
[Ispanovic, Veronika; Kircanski, Jelena Radosavljev] Univ Singidunum, Dept Psychol, Fac Media & Commun, Belgrade, Serbia.
[Miletic, Vladimir] Assoc Mental Hlth Promot, Belgrade, Serbia.
RP Milovancevic, MP (reprint author), Univ Belgrade, Inst Mental Hlth, Fac Med, Belgrade, Serbia.
EM mpejovic@eunet.rs
CR Achenbach TM, 1991, MANUAL YOUTH SELF RE
Afifi TO, 2011, CAN J PSYCHIAT, V56, P266
Baron-Cohen S, 1999, DEV COGN NEUROSCI, P401
Beavers WR, 1990, SUCCESSFUL FAMILIES
Biscoe B, 1994, RAS RESILIENCE ATTIT
Boulet Marie-Claude, 2004, Sante Ment Que, V29, P221
DODGE KA, 1990, SCIENCE, V250, P1678, DOI 10.1126/science.2270481
Egeland B., 2002, CHILDRENS SERVICES S, V5, P249, DOI DOI 10.1207/S15326918CS0504_2
Egeland B, 1996, CHILD ABUSE NEGLECT, V20, P1123, DOI 10.1016/0145-2134(96)00102-0
Flisher AJ, 1997, J AM ACAD CHILD PSY, V36, P123, DOI 10.1097/00004583-199701000-00026
Forbey DJ, 2000, CHILD ABUSE NEGL, V24, P557
Ghazarian SR, 2010, J YOUTH ADOLESCENCE, V39, P1097, DOI 10.1007/s10964-010-9544-3
Grotberg E, 1994, PROMOTING RESILIENCE
Hawkins J. D., 1998, SERIOUS VIOLENT JUVE, P106
Howell KH, 2010, VIOLENCE VICTIMS, V25, P150, DOI 10.1891/0886-6708.25.2.150
Hunter AJ, 1999, J NURS SCHOLARSHIP, V31, P243, DOI DOI 10.1111/J.1547-5069.1999.TB00488.X
KENDALLTACKETT KA, 1993, PSYCHOL BULL, V113, P164, DOI 10.1037//0033-2909.113.1.164
Lai DC, 2012, RES DEV DISABIL, V33, P909, DOI 10.1016/j.ridd.2011.12.015
Lee V, 2007, CHILD MALTREATMENT, V12, P281, DOI 10.1177/1077559507303778
LUTHAR SS, 1991, AM J ORTHOPSYCHIAT, V61, P6, DOI 10.1037/h0079218
Lyssenko L, 2010, BUNDESGESUNDHEITSBLA, V53, P1067, DOI 10.1007/s00103-010-1127-7
Magistretti PJ, 2008, SCHWEIZ ARCH NEUROL, V159, P475
Masten AS, 2001, AM PSYCHOL, V56, P227, DOI 10.1037//0003-066X.56.3.227
McCrory E, 2012, J ROY SOC MED, V105, P151, DOI 10.1258/jrsm.2011.110222
Miller BV, 1999, CHILD ABUSE NEGLECT, V23, P905, DOI 10.1016/S0145-2134(99)00059-9
PAPAZIAN B, 1994, PSYCHIAT ENFANT, V37, P353
Parker JG, 1996, DEV PSYCHOL, V32, P1025
Pejovic Milovancevic M, 2012, MANUAL APPL SPECIAL
Peters SR, 1998, CORRECTIONS TODAY, V60, P28
Pitzer LM, 2010, J GERONTOL B-PSYCHOL, V65, P425, DOI 10.1093/geronb/gbq031
Rousseau C, 2003, J REFUG STUD, V16, P67, DOI 10.1093/jrs/16.1.67
RUTTER M, 1993, J ADOLESCENT HEALTH, V14, P626, DOI 10.1016/1054-139X(93)90196-V
RUTTER M, 1987, AM J ORTHOPSYCHIAT, V57, P316
Rutter M, 1993, J ADOLESCENT HEALTH, V14, P690
Strand JA, 1999, AM IND ALSKA NATIVE
Vandivere S, 2004, CHANGES CHILDRENS WE
Widom CS, 2000, CHILDHOOD VICTIMIZAT
Williams J, 2012, CHILD ABUSE NEGLECT, V36, P53, DOI 10.1016/j.chiabu.2011.07.004
NR 38
TC 1
Z9 1
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PD JUN
PY 2014
VL 71
IS 6
BP 565
EP 570
DI 10.2298/VSP1406565P
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AU7YH
UT WOS:000345813700007
PM 25039111
ER
PT J
AU Drapeau, E
Dorr, NP
Elder, GA
Buxbaum, JD
AF Drapeau, Elodie
Dorr, Nate P.
Elder, Gregory A.
Buxbaum, Joseph D.
TI Absence of strong strain effects in behavioral analyses of
Shank3-deficient mice
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
DE Shank3; Phelan-McDermid syndrome; Autism spectrum disorders; 22q13;
Mouse strain; Genetic modifier; Behavior
ID AUTISM SPECTRUM DISORDERS; 22Q13 DELETION SYNDROME; COPY NUMBER
VARIATION; INBRED MOUSE STRAINS; POSTSYNAPTIC DENSITY PROTEINS; KNOCKOUT
MICE; MUTANT MICE; SYNAPTIC FUNCTION; LABORATORY MICE; SHANK FAMILY
AB Haploinsufficiency of SHANK3, caused by chromosomal abnormalities or mutations that disrupt one copy of the gene, leads to a neurodevelopmental syndrome called Phelan-McDermid syndrome, symptoms of which can include absent or delayed speech, intellectual disability, neurological changes and autism spectrum disorders. The SHANK3 protein forms a key structural part of the post-synaptic density. We previously generated and characterized mice with a targeted disruption of Shank3 in which exons coding for the ankyrin-repeat domain were deleted and expression of full-length Shank3 was disrupted. We documented specific deficits in synaptic function and plasticity, along with reduced reciprocal social interactions, in Shank3 heterozygous mice. Changes in phenotype owing to a mutation at a single locus are quite frequently modulated by other loci, most dramatically when the entire genetic background is changed. In mice, each strain of laboratory mouse represents a distinct genetic background and alterations in phenotype owing to gene knockout or transgenesis are frequently different across strains, which can lead to the identification of important modifier loci. We have investigated the effect of genetic background on phenotypes of Shank3 heterozygous, knockout and wild-type mice, using C57BL/6, 129SVE and FVB/Ntac strain backgrounds. We focused on observable behaviors with the goal of carrying out subsequent analyses to identify modifier loci. Surprisingly, there were very modest strain effects over a large battery of analyses. These results indicate that behavioral phenotypes associated with Shank3 haploinsufficiency are largely strain-independent.
C1 [Drapeau, Elodie; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[Drapeau, Elodie; Dorr, Nate P.; Elder, Gregory A.; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
[Elder, Gregory A.; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
[Elder, Gregory A.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA.
[Elder, Gregory A.] James J Peters VA Med Ctr, Neurol Serv, Bronx, NY 10468 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Syst Biol Ctr New York, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
RP Buxbaum, JD (reprint author), Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
FU National Institutes of Health [R01MH093725]; Beatrice and Samuel A.
Seaver Foundation; Simons Foundation Autism Research Initiative
FX This work was supported by the National Institutes of Health [grant
number: R01MH093725], the Beatrice and Samuel A. Seaver Foundation, and
the Simons Foundation Autism Research Initiative.
CR Arons MH, 2012, J NEUROSCI, V32, P14966, DOI 10.1523/JNEUROSCI.2215-12.2012
Baker KB, 2010, GENES BRAIN BEHAV, V9, P562, DOI 10.1111/j.1601-183X.2010.00585.x
Betancur C, 2009, TRENDS NEUROSCI, V32, P402, DOI 10.1016/j.tins.2009.04.003
Betancur C, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-17
Boeckers TM, 1999, BIOCHEM BIOPH RES CO, V264, P247, DOI 10.1006/bbrc.1999.1489
Boeckers TM, 2006, CELL TISSUE RES, V326, P409, DOI 10.1007/s00441-006-0274-5
Bolivar VJ, 2001, MAMM GENOME, V12, P651, DOI 10.1007/s003350020039
Bonaglia MC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002173
Bonaglia MC, 2006, J MED GENET, V43, P822, DOI 10.1136/jmg.2005.038604
Bothe GWM, 2004, GENES BRAIN BEHAV, V3, P149, DOI 10.1111/j.1601-183x.2004.00064.x
Bothe GWM, 2005, COMPARATIVE MED, V55, P326
Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
Bremer A, 2011, AM J MED GENET B, V156B, P115, DOI 10.1002/ajmg.b.31142
Buchovecky CM, 2013, NAT GENET, V45, P1013, DOI 10.1038/ng.2714
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Crawley JN, 1997, PSYCHOPHARMACOLOGY, V132, P107, DOI 10.1007/s002130050327
Cusmano-Ozog K, 2007, AM J MED GENET C, V145C, P393, DOI 10.1002/ajmg.c.30155
Dhar SU, 2010, AM J MED GENET A, V152A, P573, DOI 10.1002/ajmg.a.33253
Dobkin C, 2000, NEUROSCIENCE, V100, P423, DOI 10.1016/S0306-4522(00)00292-X
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Durand CM, 2012, MOL PSYCHIATR, V17, P71, DOI 10.1038/mp.2011.57
Errijgers V, 2008, GENET RES, V90, P341, DOI 10.1017/S0016672308009415
Farley SJ, 2011, BEHAV NEUROSCI, V125, P871, DOI 10.1037/a0026033
Garner JP, 2004, COMPARATIVE MED, V54, P216
Garner JP, 2004, APPL ANIM BEHAV SCI, V89, P263, DOI 10.1016/j.applanim.2004.07.004
Gerlai R, 1998, BEHAV BRAIN RES, V95, P91, DOI 10.1016/S0166-4328(97)00214-3
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
Goizet C, 2000, AM J MED GENET, V96, P839, DOI 10.1002/1096-8628(20001204)96:6<839::AID-AJMG29>3.0.CO;2-R
Gong XH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034739
Grabrucker AM, 2011, EMBO J, V30, P569, DOI 10.1038/emboj.2010.336
Grillo E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056599
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
Havens JM, 2004, CLIN PEDIATR, V43, P43, DOI 10.1177/000992280404300106
Herbert MR, 2011, NEW ENGL J MED, V365, P173, DOI 10.1056/NEJMcibr1104261
Holmes A, 2002, GENES BRAIN BEHAV, V1, P55, DOI 10.1046/j.1601-1848.2001.00005.x
Hughes RN, 2004, NEUROSCI BIOBEHAV R, V28, P497, DOI 10.1016/j.neubiorev.2004.06.006
Jeffries AR, 2005, AM J MED GENET A, V137A, P139, DOI 10.1002/ajmg.a.30780
Kalueff AV, 2007, BEHAV BRAIN RES, V177, P45, DOI 10.1016/j.bbr.2006.11.005
Kalueff AV, 2006, BEHAV PROCESS, V71, P8, DOI 10.1016/j.beproc.2005.09.004
Kreienkamp H-J., 2008, V186, P365
Kurien BT, 2005, BRIT MED J, V331, P1503
Manning MA, 2004, PEDIATRICS, V114, P451, DOI 10.1542/peds.114.2.451
Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
Moruzzi S, 2011, J AUTISM DEV DISORD, V41, P1665, DOI 10.1007/s10803-011-1199-8
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
Naisbitt S, 1999, NEURON, V23, P569, DOI 10.1016/S0896-6273(00)80809-0
Owen EH, 1997, NEUROSCIENCE, V80, P1087, DOI 10.1016/S0306-4522(97)00165-6
Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
Phelan K., 2011, EUR J HUM GENET, V19, P19
Phelan MC, 2008, ORPHANET J RARE DIS, V3, DOI 10.1186/1750-1172-3-14
Philippe A, 2008, PEDIATRICS, V122, pE376, DOI 10.1542/peds.2007-2584
Pietropaolo Susanna, 2011, PLoS One, V6, pe17073, DOI 10.1371/journal.pone.0017073
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Prasad C, 2000, CLIN GENET, V57, P103, DOI 10.1034/j.1399-0004.2000.570203.x
Qiao Y, 2009, J MED GENET, V46, P680, DOI 10.1136/jmg.2009.066795
Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
Rosenfeld JA, 2010, GENET MED, V12, P694, DOI 10.1097/GIM.0b013e3181f0c5f3
Roussignol G, 2005, J NEUROSCI, V25, P3560, DOI 10.1523/JNEUROSCI.4354-04.2005
Sala C, 2001, NEURON, V31, P115, DOI 10.1016/S0896-6273(01)00339-7
Sarasua SM, 2011, J MED GENET, V48, P761, DOI 10.1136/jmedgenet-2011-100225
Sarna JR, 2000, BEHAV BRAIN RES, V108, P39, DOI 10.1016/S0166-4328(99)00137-0
Schaefer GB, 2010, J CHILD NEUROL, V25, P1498, DOI 10.1177/0883073810370479
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Sheng M, 2000, J CELL SCI, V113, P1851
Soorya L, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-18
Spencer CM, 2011, AUTISM RES, V4, P40, DOI 10.1002/aur.168
Sykes NH, 2009, EUR J HUM GENET, V17, P1347, DOI 10.1038/ejhg.2009.47
Tu JC, 1999, NEURON, V23, P583, DOI 10.1016/S0896-6273(00)80810-7
Tynes Valarie V., 2013, Veterinary Clinics of North America Exotic Animal Practice, V16, P801, DOI 10.1016/j.cvex.2013.05.004
Verpelli C, 2011, J BIOL CHEM, V286, P34839, DOI 10.1074/jbc.M111.258384
Waga C, 2011, PSYCHIAT GENET, V21, P208, DOI 10.1097/YPG.0b013e328341e069
Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
Wilson HL, 2003, J MED GENET, V40, P575, DOI 10.1136/jmg.40.8.575
Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
NR 75
TC 0
Z9 0
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD JUN
PY 2014
VL 7
IS 6
BP 667
EP 681
DI 10.1242/dmm.013821
PG 15
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA AT5SQ
UT WOS:000345002600008
PM 24652766
ER
PT J
AU An, JY
Cristino, AS
Zhao, Q
Edson, J
Williams, SM
Ravine, D
Wray, J
Marshall, VM
Hunt, A
Whitehouse, AJO
Claudianos, C
AF An, J. Y.
Cristino, A. S.
Zhao, Q.
Edson, J.
Williams, S. M.
Ravine, D.
Wray, J.
Marshall, V. M.
Hunt, A.
Whitehouse, A. J. O.
Claudianos, C.
TI Towards a molecular characterization of autism spectrum disorders: an
exome sequencing and systems approach
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID DE-NOVO MUTATIONS; GENETIC-VARIANTS; ASSOCIATION; DISEASE; FEATURES;
SNPS; NEUROLIGINS; ANNOTATION; NEUREXINS; PHENOTYPE
AB The hypothetical 'AXAS' gene network model that profiles functional patterns of heterogeneous DNA variants overrepresented in autism spectrum disorder (ASD), X-linked intellectual disability, attention deficit and hyperactivity disorder and schizophrenia was used in this current study to analyze whole exome sequencing data from an Australian ASD cohort. An optimized DNA variant filtering pipeline was used to identify loss-of-function DNA variations. Inherited variants from parents with a broader autism phenotype and de novo variants were found to be significantly associated with ASD. Gene ontology analysis revealed that putative rare causal variants cluster in key neurobiological processes and are overrepresented in functions involving neuronal development, signal transduction and synapse development including the neurexin trans-synaptic complex. We also show how a complex gene network model can be used to fine map combinations of inherited and de novo variations in families with ASD that converge in the L1CAM pathway. Our results provide an important step forward in the molecular characterization of ASD with potential for developing a tool to analyze the pathogenesis of individual affected families.
C1 [An, J. Y.; Cristino, A. S.; Zhao, Q.; Edson, J.; Williams, S. M.; Marshall, V. M.; Claudianos, C.] Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia.
[Ravine, D.] Sch Pathol & Lab Med, Perth, WA, Australia.
[Wray, J.] Princess Margaret Hosp Children, State Child Dev Ctr, Child & Adolescent Hlth Serv, Perth, WA, Australia.
[Hunt, A.; Whitehouse, A. J. O.] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Subiaco, WA, Australia.
[Whitehouse, A. J. O.; Claudianos, C.] Cooperat Res Ctr Living Autism Spectrum Disorders, Brisbane, Qld, Australia.
RP Claudianos, C (reprint author), Univ Queensland, Queensland Brain Inst, Bldg 79, St Lucia, Qld 4072, Australia.
EM c.claudianos@uq.edu.au
RI Zhao, Qiongyi/B-4106-2014; Cristino, Alexandre/A-5834-2012
OI Zhao, Qiongyi/0000-0002-6341-0416; Cristino,
Alexandre/0000-0002-3468-0919
FU Commonwealth Department of Social Services; Cooperative Research Centre
for Living; Autism Spectrum Disorders the Autism CRC; Australian
Government's Cooperative Research Centres program; Australian Research
Council [FT110100292]; National Health and Medical Research Council
[APP1008125, APP1004065]; University of Queensland PhD scholarship;
Australian Postgraduate Award
FX We thank the families that participated in our study and R Tweedale, J
Reinhard and A Larkin for critical reading of the manuscript. We
acknowledge the financial support of the Commonwealth Department of
Social Services (formerly the Department of Families, Housing, Community
Services and Indigenous Affairs) and the Cooperative Research Centre for
Living with Autism Spectrum Disorders the Autism CRC, established and
supported under the Australian Government's Cooperative Research Centres
program. CC was supported by funding from the Australian Research
Council (FT110100292) and CC and AJOW by funding from the National
Health and Medical Research Council (APP1008125; APP1004065). JYA was
supported by a University of Queensland PhD scholarship and SMW by an
Australian Postgraduate Award. We also thank John Beilby and PathWest
for facilitating collection of samples and patient data.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
Bamshad MJ, 2011, NAT REV GENET, V12, P745, DOI 10.1038/nrg3031
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247]
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bi C, 2012, HUM MUTAT, V33, P1635, DOI 10.1002/humu.22174
Bindea G, 2009, BIOINFORMATICS, V25, P1091, DOI 10.1093/bioinformatics/btp101
Bruno AE, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-44
Carter MT, 2013, CLIN GENET, V83, P399, DOI 10.1111/cge.12101
Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
Cheng L, 2004, MOL CELL NEUROSCI, V27, P522, DOI 10.1016/j.mcn.2004.08.005
Conroy J, 2009, AM J MED GENET B, V150B, P535, DOI 10.1002/ajmg.b.30854
Correia C, 2009, AM J MED GENET B, V150B, P1147, DOI 10.1002/ajmg.b.30940
Cristino AS, 2014, MOL PSYCHIATR, V19, P294, DOI 10.1038/mp.2013.16
DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Eapen V, 2011, CURR OPIN PSYCHIATR, V24, P226, DOI 10.1097/YCO.0b013e328345927e
Enneking EM, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001537
Enright AJ, 2004, GENOME BIOL, V5
Fajardo KVF, 2012, HUM MUTAT, V33, P609, DOI 10.1002/humu.22033
Georgiades S, 2013, JAMA PSYCHIAT, V70, P42, DOI 10.1001/2013.jamapsychiatry.1
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
Gong J, 2012, HUM MUTAT, V33, P254, DOI 10.1002/humu.21641
Heinzen EL, 2012, AM J HUM GENET, V91, P293, DOI 10.1016/j.ajhg.2012.06.016
Hu J, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-2-r9
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
Kozomara A, 2011, NUCLEIC ACIDS RES, V39, pD152, DOI 10.1093/nar/gkq1027
Krumm N, 2013, TRENDS NEUROSCI, V37, P95
Kryukov GV, 2007, AM J HUM GENET, V80, P727, DOI 10.1086/513473
Ku CS, 2013, MOL PSYCHIATR, V18, P141, DOI 10.1038/mp.2012.58
Kudumala S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076974
Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
Li YR, 2010, NAT GENET, V42, P969, DOI 10.1038/ng.680
Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
Liu XM, 2011, HUM MUTAT, V32, P894, DOI 10.1002/humu.21517
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Maness PF, 2007, NAT NEUROSCI, V10, P19, DOI 10.1038/nn1827
Marui T, 2009, INT J NEUROPSYCHOPH, V12, P1, DOI 10.1017/S1461145708009127
McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Need AC, 2012, AM J HUM GENET, V91, P303, DOI 10.1016/j.ajhg.2012.06.018
Nielsen R, 2011, NAT REV GENET, V12, P443, DOI 10.1038/nrg2986
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
Pilz DT, 1998, HUM MOL GENET, V7, P2029, DOI 10.1093/hmg/7.13.2029
Pippucci T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082154
Quinlan AR, 2010, BIOINFORMATICS, V26, P841, DOI 10.1093/bioinformatics/btq033
Ramoz N, 2008, AM J MED GENET B, V147B, P1152, DOI 10.1002/ajmg.b.30739
Rehmsmeier M, 2004, RNA, V10, P1507, DOI 10.1021/rna.5248604
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schwichtenberg AJ, 2013, AUTISM RES, V6, P169, DOI 10.1002/aur.1278
Shi LL, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-8
Smoot ME, 2011, BIOINFORMATICS, V27, P431, DOI 10.1093/bioinformatics/btq675
Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
Taylor LJ, 2013, J AUTISM DEV DISORD, V43, P2984, DOI 10.1007/s10803-013-1838-3
Toma C, 2014, MOL PSYCHIATR, V19, P784, DOI 10.1038/mp.2013.106
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Wang K, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq603
Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
Won H, 2013, FRONT MOL NEUROSCI, V6, DOI 10.3389/fnmol.2013.00019
Wright GJ, 2011, J NEUROCHEM, V117, P765, DOI 10.1111/j.1471-4159.2010.07141.x
Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
NR 70
TC 4
Z9 5
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUN
PY 2014
VL 4
AR e394
DI 10.1038/tp.2014.38
PG 9
WC Psychiatry
SC Psychiatry
GA AT3HN
UT WOS:000344826500002
PM 24893065
ER
PT J
AU Naviaux, JC
Schuchbauer, MA
Li, K
Wang, L
Risbrough, VB
Powell, SB
Naviaux, RK
AF Naviaux, J. C.
Schuchbauer, M. A.
Li, K.
Wang, L.
Risbrough, V. B.
Powell, S. B.
Naviaux, R. K.
TI Reversal of autism-like behaviors and metabolism in adult mice with
single-dose antipurinergic therapy
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID PRENATAL IMMUNE ACTIVATION; SPECTRUM DISORDERS; PYRIMIDINE METABOLISM;
NEURODEVELOPMENTAL DISORDERS; PURINE METABOLISM; AREA POSTREMA;
SCHIZOPHRENIA; RECEPTORS; ABNORMALITIES; CHILDREN
AB Autism spectrum disorders (ASDs) now affect 1-2% of the children born in the United States. Hundreds of genetic, metabolic and environmental factors are known to increase the risk of ASD. Similar factors are known to influence the risk of schizophrenia and bipolar disorder; however, a unifying mechanistic explanation has remained elusive. Here we used the maternal immune activation (MIA) mouse model of neurodevelopmental and neuropsychiatric disorders to study the effects of a single dose of the antipurinergic drug suramin on the behavior and metabolism of adult animals. We found that disturbances in social behavior, novelty preference and metabolism are not permanent but are treatable with antipurinergic therapy (APT) in this model of ASD and schizophrenia. A single dose of suramin (20 mg kg(-1) intraperitoneally (i.p.)) given to 6-month-old adults restored normal social behavior, novelty preference and metabolism. Comprehensive metabolomic analysis identified purine metabolism as the key regulatory pathway. Correction of purine metabolism normalized 17 of 18 metabolic pathways that were disturbed in the MIA model. Two days after treatment, the suramin concentration in the plasma and brainstem was 7.64 mu M pmol mu l(-1) (+/-0.50) and 5.15 pmol mg(-1) (+/-0.49), respectively. These data show good uptake of suramin into the central nervous system at the level of the brainstem. Most of the improvements associated with APT were lost after 5 weeks of drug washout, consistent with the 1-week plasma half-life of suramin in mice. Our results show that purine metabolism is a master regulator of behavior and metabolism in the MIA model, and that single-dose APT with suramin acutely reverses these abnormalities, even in adults.
C1 [Naviaux, J. C.; Schuchbauer, M. A.; Risbrough, V. B.; Powell, S. B.] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA.
[Li, K.; Wang, L.; Naviaux, R. K.] Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, San Diego, CA 92103 USA.
[Li, K.; Wang, L.; Naviaux, R. K.] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA.
[Risbrough, V. B.; Naviaux, R. K.] Vet Affairs Ctr Excellence Stress & Mental Hlth C, La Jolla, CA USA.
[Naviaux, R. K.] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA.
[Naviaux, R. K.] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA.
RP Naviaux, JC (reprint author), Univ Calif San Diego, Sch Med, Dept Med, 214 Dickinson St,Bldg CTF,Room C102, San Diego, CA 92103 USA.
EM naviaux@ucsd.edu
FU Jane Botsford Johnson Foundation (RKN); National Institute of Health
[MH091407]; UCSD Christini Foundation; Wright Family Foundation; It
Takes Guts Foundation
FX We thank Dewleen Baker, Sophia Colamarino, Richard Haas, William Nyhan,
Maya Shetreat-Klein, Leanne Chukoskie, Jeanne Townsend, Will Alaynick,
Andrea Chiba, Ben Murrell, Jim Adams and Steve Edelson for helpful
discussions and comments on the manuscript. We thank Laura Dugan for
providing the rotarod and comments on the manuscript. We thank two
anonymous reviewers for helpful comments. This research was supported by
grants from the Jane Botsford Johnson Foundation (RKN) and National
Institute of Health grant MH091407 (SBP), with additional support from
the UCSD Christini Foundation, the Wright Family Foundation and the It
Takes Guts Foundation to RKN. The funders had no role in the study
design, data collection and analysis, decision to publish or preparation
of the manuscript.
CR Abbracchio MP, 2009, TRENDS NEUROSCI, V32, P19, DOI 10.1016/j.tins.2008.10.001
Accardi MV, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4168
Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
Bajad S, 2011, METHODS MOL BIOL, V708, P213, DOI 10.1007/978-1-61737-985-7_13
BECKER MA, 1980, J CLIN INVEST, V65, P109, DOI 10.1172/JCI109640
BERGER R, 1984, CLIN CHIM ACTA, V141, P227, DOI 10.1016/0009-8981(84)90014-7
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bicikova M, 2013, J STEROID BIOCHEM, V133, P77, DOI 10.1016/j.jsbmb.2012.08.009
Bitanihirwe BKY, 2010, NEUROPSYCHOPHARMACOL, V35, P2462, DOI 10.1038/npp.2010.129
Brockhaus J, 2004, EUR J NEUROSCI, V19, P2221, DOI 10.1111/j.1460-9568.2004.03325.x
Burnstock G, 2013, ADV EXP MED BIOL, V986, P1, DOI 10.1007/978-94-007-4719-7_1
BURNSTOC.G, 1972, BRIT J PHARMACOL, V46, P234
Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
Chen JD, 2013, GLIA, V61, P178, DOI 10.1002/glia.22425
Chen JF, 2013, NAT REV DRUG DISCOV, V12, P265, DOI 10.1038/nrd3955
Ciardo F, 2001, J CHILD NEUROL, V16, P301, DOI 10.1177/088307380101600501
Curran LK, 2007, PEDIATRICS, V120, pE1386, DOI 10.1542/peds.2007-0360
Dias RB, 2013, TRENDS NEUROSCI, V36, P248, DOI 10.1016/j.tins.2012.12.003
Eltzschig HK, 2012, NEW ENGL J MED, V367, P2322, DOI 10.1056/NEJMra1205750
Flurkey K, 2007, MOUSE BIOMEDICAL RES, VIII, P637
Franike H, 2009, GLIA, V57, P1031, DOI 10.1002/glia.20827
Frye CA, 2008, NEUROBIOL LEARN MEM, V89, P17, DOI 10.1016/j.nlm.2007.09.008
Gallego D, 2008, NEUROGASTROENT MOTIL, V20, P159, DOI 10.1111/j.1365-2982.2007.01004.x
Golde WT, 2005, LAB ANIMAL, V34, P39, DOI 10.1038/laban1005-39
Gotham K, 2013, AUTISM RES, V6, P33, DOI 10.1002/aur.1263
Halassa MM, 2011, SEMIN CELL DEV BIOL, V22, P245, DOI 10.1016/j.semcdb.2011.02.008
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Harvey L, 2012, DEV NEUROBIOL, V72, P1335, DOI 10.1002/dneu.22043
HAWKING F., 1940, TRANS ROY SOC TROP MED AND HYG, V34, P37, DOI 10.1016/S0035-9203(40)90088-8
Housley GD, 2002, AUDIOL NEURO-OTOL, V7, P55, DOI 10.1159/000046865
Hughes RN, 2007, NEUROSCI BIOBEHAV R, V31, P441, DOI 10.1016/j.neubiorev.2006.11.004
Intine RV, 2012, CURR DIABETES REP, V12, P551, DOI 10.1007/s11892-012-0302-7
Jacobson KA, 2012, PURINERG SIGNAL, V8, P419, DOI 10.1007/s11302-012-9294-7
Kaddurah-Daouk R, 2012, PSYCHIAT RES, V198, P347, DOI 10.1016/j.psychres.2012.02.019
Kirchhof P, 2003, AM J PHYSIOL-HEART C, V285, pH145, DOI 10.1152/ajpheart.01036.2002
Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
Lee HY, 1998, BRAIN RES BULL, V46, P495, DOI 10.1016/S0361-9230(98)00045-8
Leng YX, 2008, NEUROSCI LETT, V445, P195, DOI 10.1016/j.neulet.2008.09.014
Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
Matos JE, 2007, PFLUG ARCH EUR J PHY, V454, P977, DOI 10.1007/s00424-007-0248-9
McCusker RH, 2013, J EXP BIOL, V216, P84, DOI 10.1242/jeb.073411
McDonald ME, 2010, ENVIRON SCI TECHNOL, V44, P2112, DOI 10.1021/es902057k
MEDNICK SA, 1988, ARCH GEN PSYCHIAT, V45, P189
Micheli V, 2011, CURR TOP MED CHEM, V11, P923
Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0
Mulle JG, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-012-0337-0
Munson J, 2008, J INT NEUROPSYCH SOC, V14, P956, DOI 10.1017/S1355617708081393
Naviaux RK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057380
Naviaux R.K., 2013, MITOCHONDRION
Nordin V, 1998, DEV MED CHILD NEUROL, V40, P587
NYHAN WL, 1969, J PEDIATR, V74, P20, DOI 10.1016/S0022-3476(69)80004-1
Nyhan WL, 2005, MOL GENET METAB, V86, P25, DOI 10.1016/j.ymgme.2005.07.027
Nyhan WL, 2012, ATLAS INHERITED META, P503
Pacheco-Lopez G, 2013, SCHIZOPHRENIA BULL, V39, P319, DOI 10.1093/schbul/sbr178
Page T, 2000, BBA-MOL BASIS DIS, V1500, P291, DOI 10.1016/S0925-4439(99)00113-1
Parboosing R, 2013, JAMA PSYCHIAT, V70, P677, DOI 10.1001/jamapsychiatry.2013.896
Pascual O, 2005, SCIENCE, V310, P113, DOI 10.1126/science.1116916
Pastural E, 2009, PROSTAG LEUKOTR ESS, V81, P253, DOI 10.1016/j.plefa.2009.06.003
Patterson PH, 2011, PEDIATR RES, V69, p34R, DOI 10.1203/PDR.0b013e318212b80f
Patterson PH, 2011, INFECT BEHAV BRAIN I, P162
Pelegrin P, 2008, DRUG NEWS PERSPECT, V21, P424, DOI 10.1358/dnp.2008.21.8.1265800
Pineda DA, 2007, EUR CHILD ADOLES PSY, V16, P337, DOI 10.1007/s00787-007-0605-4
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Price CJ, 2008, NEUROSCIENTIST, V14, P182, DOI 10.1177/1073858407311100
SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
Schengrund CL, 2012, NEUROCHEM RES, V37, P1201, DOI 10.1007/s11064-011-0697-6
Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
Siso S, 2010, ACTA NEUROPATHOL, V120, P689, DOI 10.1007/s00401-010-0743-5
Smesny S, 2013, SCHIZOPHRENIA BULL, V39, P933, DOI 10.1093/schbul/sbs058
SOLA F, 1995, CANCER CHEMOTH PHARM, V36, P217, DOI 10.1007/BF00685849
Sun Y, 2008, PEDIATRICS, V121, pE1100, DOI 10.1542/peds.2007-2316
Surprenant A, 2009, ANNU REV PHYSIOL, V71, P333, DOI 10.1146/annurev.physiol.70.113006.100630
Takikawa O, 2005, BIOCHEM BIOPH RES CO, V338, P12, DOI 10.1016/j.bbrc.2005.09.032
Tierney E, 2006, AM J MED GENET B, V141B, P666, DOI 10.1002/ajmg.b.30368
Toth M, 2014, NEUROPSYCHOPHARMACOL, V39, P1409, DOI 10.1038/npp.2013.336
Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
VECERA SP, 1991, J COGNITIVE NEUROSCI, V3, P351, DOI 10.1162/jocn.1991.3.4.351
Vogel Gretchen, 2013, Science, V342, P686, DOI 10.1126/science.342.6159.686
Volk HE, 2013, JAMA PSYCHIAT, V70, P71, DOI 10.1001/jamapsychiatry.2013.266
VOOGD TE, 1993, PHARMACOL REV, V45, P177
Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
Willi R, 2013, NEUROPHARMACOLOGY, V73, P56, DOI 10.1016/j.neuropharm.2013.05.012
Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
Xia JG, 2012, NUCLEIC ACIDS RES, V40, pW127, DOI 10.1093/nar/gks374
Yao JK, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00090
Yao JK, 2010, MOL PSYCHIATR, V15, P938, DOI 10.1038/mp.2009.33
Zerbo O, 2013, J AUTISM DEV DISORD, V43, P25, DOI 10.1007/s10803-012-1540-x
Zhang Q, 2010, NATURE, V464, P104, DOI 10.1038/nature08780
NR 92
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUN
PY 2014
VL 4
AR e400
DI 10.1038/tp.2014.33
PG 11
WC Psychiatry
SC Psychiatry
GA AT3HN
UT WOS:000344826500008
PM 24937094
ER
PT J
AU Gardner, KF
Carter, EW
Gustafson, JR
Hochman, JM
Harvey, MN
Mullins, TS
Fan, H
AF Gardner, Karen F.
Carter, Erik W.
Gustafson, Jenny R.
Hochman, Julia M.
Harvey, Michelle N.
Mullins, Teagan S.
Fan, Hannah
TI Effects of Peer Networks on the Social Interactions of High School
Students With Autism Spectrum Disorders
SO RESEARCH AND PRACTICE FOR PERSONS WITH SEVERE DISABILITIES
LA English
DT Article
DE social relationships; high school; peer-mediated intervention; autism;
adolescence
ID INTELLECTUAL DISABILITIES; INTERVENTION; CLASSROOMS
AB Supporting social interactions and positive peer relationships is an important element of comprehensive secondary education and transition programming. For many adolescents with autism spectrum disorders (ASDs), such social connections may be fairly limited apart from intentional programming. We examined the efficacy and social validity of peer network interventions as an avenue for promoting social interactions and social skills for two high school students with ASD. The introduction of peer networks was accompanied by substantial increases in peer interactions for both students. Adult facilitators, peer partners, and students with ASD each considered the intervention to be acceptable and feasible to implement. We offer recommendations for designing social-focused interventions for adolescents with ASD and highlight future research directions.
C1 [Gardner, Karen F.] Vanderbilt Univ, Peabody Coll, Nashville, TN 37203 USA.
[Carter, Erik W.; Gustafson, Jenny R.] Vanderbilt Univ, Dept Special Educ, Nashville, TN 37203 USA.
[Hochman, Julia M.] Vanderbilt Univ, Peer Partner Project, Nashville, TN 37203 USA.
[Harvey, Michelle N.; Mullins, Teagan S.; Fan, Hannah] Vanderbilt Univ, Nashville, TN 37203 USA.
RP Carter, EW (reprint author), Vanderbilt Univ, Dept Special Educ, Peabody Coll, 230 Appleton Pl,PMB 228, Nashville, TN 37203 USA.
EM erik.carter@vanderbilt.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Carter E. W., 2009, PEER SUPPORT STRATEG
Carter E. W., 2012, TREATMENT AUTISM SPE, P221
Carter E. W., 2013, TEACHING EXCEPTIONAL, V46, P51
Carter EW, 2010, RES PRACT PERS SEV D, V35, P63
Carter EW, 2005, AM J MENT RETARD, V110, P366, DOI 10.1352/0895-8017(2005)110[366:FISIAH]2.0.CO;2
Carter EW, 2014, REM SPEC EDUC, V35, P91, DOI 10.1177/0741932513514618
Carter EW, 2008, EXCEPTIONALITY, V16, P156, DOI 10.1080/09362830802198427
Carter EW, 2008, AM J MENT RETARD, V113, P479, DOI 10.1352/2008.113:479-494
Gresham F. M., 2008, SOCIAL SKILLS IMPROV
HARING TG, 1992, J APPL BEHAV ANAL, V25, P319, DOI 10.1901/jaba.1992.25-319
Hughes C, 2013, FOCUS AUTISM DEV DIS, V28, P241, DOI 10.1177/1088357613487019
Hughes C., 2013, RES PRACT PERS SEV D, V37, P288, DOI 10.2511/027494813805327214
Humphrey N., 2010, EUROPEAN J SPECIAL N, V25, P77, DOI DOI 10.1080/08856250903450855
Kennedy C, 2005, SINGLE CASE DESIGNS
Koegel RL, 2012, J POSIT BEHAV INTERV, V14, P133, DOI 10.1177/1098300712437043
Locke J., 2010, J RES SPECIAL ED NEE, V10, P74, DOI DOI 10.1111/J.1471-3802.2010.01148.X
Meyer L., 1998, MAKING FRIENDS INFLU
Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
Rossetti ZS, 2011, RES PRACT PERS SEV D, V36, P23
Rubin K., 2009, HDB PEER INTERACTION
Schopler E., 2010, CHILDHOOD AUTISM RAT, VSecond
Shattuck PT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027176
Snell ME, 2003, RES PRACT PERS SEV D, V28, P143, DOI 10.2511/rpsd.28.3.143
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Van der Klift E., 1994, CREATIVITY COLLABORA, P21
Wagner M., 2004, SOCIAL ACTIVITIES YO
Wentzel KR, 2012, ADOLESC EDUC, P79
NR 28
TC 0
Z9 0
PU TASH
PI WASHINGTON
PA 1025 VERMONT AVE, NW 7TH FLR, WASHINGTON, DC 20005 USA
SN 0274-9483
J9 RES PRACT PERS SEV D
JI Res. Pract. Pers. Sev. Disabil.
PD JUN
PY 2014
VL 39
IS 2
BP 100
EP 118
DI 10.1177/1540796914544550
PG 19
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AR5FU
UT WOS:000343611400002
ER
PT J
AU Schafer, EC
Bryant, D
Sanders, K
Baldus, N
Algier, K
Lewis, A
Traber, J
Layden, P
Amin, A
AF Schafer, Erin C.
Bryant, Danielle
Sanders, Katie
Baldus, Nicole
Algier, Katherine
Lewis, Audrey
Traber, Jordan
Layden, Paige
Amin, Aneeqa
TI Fitting and Verification of Frequency Modulation Systems on Children
with Normal Hearing
SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY
LA English
DT Article
DE Fitting; FM systems; normal hearing
ID AUTISM SPECTRUM DISORDERS; PERSONAL FM SYSTEMS; FRIEDREICH ATAXIA;
SPEECH; NOISE; INDIVIDUALS; DYSLEXIA
AB Background: Several recent investigations support the use of frequency modulation (FM) systems in children with normal hearing and auditory processing or listening disorders such as those diagnosed with auditory processing disorders, autism spectrum disorders, attention-deficit hyperactivity disorder, Friedreich ataxia, and dyslexia. The American Academy of Audiology (AAA) published suggested procedures, but these guidelines do not cite research evidence to support the validity of the recommended procedures for fitting and verifying nonoccluding open-ear FM systems on children with normal hearing. Documenting the validity of These fitting procedures is critical to maximize the potential FM-system benefit in the abovementioned populations of children with normal hearing and those with auditory-listening problems.
Purpose: The primary goal of this investigation was to determine the validity of the AAA real-ear approach to fitting FM systems on children with normal hearing. The secondary goal of this study was to examine speech-recognition performance in noise and loudness ratings without and with FM systems in children with normal hearing sensitivity.
Research Design: A two-group, cross-sectional design was used in the present study.
Study Sample: Twenty-six typically functioning children, ages 5-12 yr, with normal hearing sensitivity participated in the study.
Intervention: Participants used a nonoccluding open-ear FM receiver during laboratory-based testing.
Data Collection and Analysis: Participants completed three laboratory tests: (1) real-ear measures, (2) speech recognition performance in noise, and (3) loudness ratings. Four real-ear measures were conducted to (1) verify that measured output met prescribed-gain targets across the 1000-4000 Hz frequency range for speech stimuli, (2) confirm that the FM-receiver volume did not exceed predicted uncomfortable loudness levels, and (3 and 4) measure changes to the real-ear unaided response when placing the FM receiver in the child's ear. After completion of the fitting, speech recognition in noise at a 5 signal-to-noise ratio and loudness ratings at a +5 signal-to-noise ratio were measured in four conditions: (1) no FM system, (2) FM receiver on the right ear, (3) FM receiver on the left ear, and (4) bilateral FM system.
Results: The results of this study suggested that the slightly modified AAA real-ear measurement procedures resulted in a valid fitting of one FM system on children with normal hearing. On average, prescriptive targets were met for 1000, 2000, 3000, and 4000 Hz within 3 dB, and maximum output of the FM system never exceeded and was significantly lower than predicted uncomfortable loudness levels for the children. There was a minimal change in the real-ear unaided response when the open-ear FM receiver was placed into the ear. Use of the FM system on one-or both ears resulted in significantly better speech recognition in noise relative to a no-FM condition, and the unilateral and bilateral FM receivers resulted in a comfortably loud signal when listening in background noise.
Conclusions: Real-ear measures are critical for obtaining an appropriate fit of an FM system on children with normal hearing.
C1 [Schafer, Erin C.; Bryant, Danielle; Sanders, Katie; Baldus, Nicole; Algier, Katherine; Lewis, Audrey; Traber, Jordan; Layden, Paige; Amin, Aneeqa] Univ N Texas, Dept Speech & Hearing Sci, Denton, TX 76203 USA.
RP Schafer, EC (reprint author), Univ N Texas, Dept Speech & Hearing Sci, 1155 Union Circle 305010, Denton, TX 76203 USA.
EM Erin.Schafer@unt.edu
FU Phonak AG
FX Funding for this study was provided by Phonak AG. The funds were used to
compensate participants for their time, efforts, and mileage to the test
center. The authors of this manuscript received no monetary compensation
related to the study. The equipment for the study was loaned to the
investigators by Phonak AG and returned after the study was completed.
CR Alcantara JI, 2004, J CHILD PSYCHOL PSYC, V45, P1107, DOI 10.1111/j.1469-7610.2004.t01-1-00303.x
American Academy of Audiology, 2008, CLIN PRACT GUID REM
Barry RJ, 2002, CLIN NEUROPHYSIOL, V113, P579, DOI 10.1016/S1388-2457(02)00036-6
Centanni TM, 2014, CEREB CORTEX, V24, P1753, DOI 10.1093/cercor/bht028
Etymotic Research, 2005, BAMF KOW BENCH SPEEC
Hornickel J, 2012, P NATL ACAD SCI USA, V109, P16731, DOI 10.1073/pnas.1206628109
Johnston KN, 2009, INT J AUDIOL, V48, P371, DOI 10.1080/14992020802687516
Purdy SC, 2009, INT J AUDIOL, V48, P843, DOI 10.3109/14992020903140910
Rance G, 2012, J CHILD NEUROL, V27, P1197, DOI 10.1177/0883073812448963
Rance G, 2010, NEUROSCIENCE, V171, P552, DOI 10.1016/j.neuroscience.2010.09.013
Rothpletz AM, 2004, J SPEECH LANG HEAR R, V47, P269, DOI 10.1044/1092-4388(2004/022)
Russo N, 2009, DEVELOPMENTAL SCI, V12, P557, DOI 10.1111/j.1467-7687.2008.00790.x
Russo N, 2009, J AUTISM DEV DISORD, V39, P1185, DOI 10.1007/s10803-009-0737-0
Schafer EC, 2013, J COMMUN DISORD, V46, P30, DOI 10.1016/j.jcomdis.2012.09.002
Schafer EC., 2010, J EDU AUDIOL, V16, P4
Scollie Susan, 2005, Trends Amplif, V9, P159, DOI 10.1177/108471380500900403
Sharma M, 2012, INT J AUDIOL, V51, P506, DOI 10.3109/14992027.2012.670272
Shield B, 2004, J ACOUST SOC AM, V115, P730, DOI 10.1121/1.1635837
NR 18
TC 0
Z9 0
PU AMER ACAD AUDIOLOGY
PI RESTON
PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA
SN 1050-0545
EI 2157-3107
J9 J AM ACAD AUDIOL
JI J. Am. Acad. Audiol.
PD JUN
PY 2014
VL 25
IS 6
BP 529
EP 540
DI 10.3766/jaaa.25.6.3
PG 12
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA AQ3XE
UT WOS:000342726000003
PM 25313543
ER
PT J
AU Galloway, AR
AF Galloway, Alexander R.
TI THE AUTISM OF REASON
SO ANGELAKI-JOURNAL OF THE THEORETICAL HUMANITIES
LA English
DT Article
C1 NYU, New York, NY 10003 USA.
RP Galloway, AR (reprint author), NYU, 239 Greene St,8th Floor, New York, NY 10003 USA.
EM galloway@nyu.edu
CR Agamben Giorgio, 1993, COMING COMMUNITY
Badiou Alain, 2005, BEING EVENT
Debord G., 1994, SOC SPECTACLE
Deleuze G., 1984, KANTS CRITICAL PHILO
Kant Immanuel, 1902, PROLEGOMENA ANY FUTU
Laruelle Francois, 1987, DECISION PHILOS, VI, P86
Laruelle Francois, 2010, FUTURE CHRIST LESSON
Laruelle Francois, 2011, CONCEPT NONPHOTOGRAP
Laruelle Francois, 2003, ULTIME HONNEUR INTEL
Laruelle Francois, 2011, SPECULATIVE TURN CON, P237
Laruelle Francois, 2005, THEORIE REBELLION UL
Laruelle Francois, 1996, PRINCIPES NONPHILOSO
Laruelle Francois, 1987, DECISION PHILOS, V1, P83
Marx K., 1976, CAPITAL, V1
Ranciere J, 1974, LECON ALTHUSSER
NR 15
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0969-725X
EI 1469-2899
J9 ANGELAKI
JI Angelaki-J Theor. Humanit.
PD JUN
PY 2014
VL 19
IS 2
SI SI
BP 73
EP 83
DI 10.1080/0969725X.2014.950863
PG 11
WC Humanities, Multidisciplinary
SC Arts & Humanities - Other Topics
GA AP5QF
UT WOS:000342133000008
ER
PT J
AU Verkhratsky, A
Parpura, V
AF Verkhratsky, Alexei
Parpura, Vladimir
TI Neurological and psychiatric disorders as a neuroglial failure
SO PERIODICUM BIOLOGORUM
LA English
DT Article
DE neuroglia; astrocyte; oligodendrocyte; microglia; reactive gliosis; NG2
glia; neurological diseases; neurodegeneration; psychiatric diseases
ID AMYOTROPHIC-LATERAL-SCLEROSIS; AUTISM SPECTRUM DISORDERS; TRANSGENIC
ANIMAL-MODEL; DISEASE MOUSE MODEL; ALZHEIMERS-DISEASE; REACTIVE GLIOSIS;
FRONTOTEMPORAL DEMENTIA; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE;
KYNURENIC ACID
AB Neuroglia are a diverse non-neuronal population of cells in the central and peripheral nervous system. These cells have a variety of functions that can all be summed up as the maintenance of homeostasis of the nervous system. It is the loss of homeostasis that represents the culprit of all disorders. Thus, neuroglia can be envisioned as the pivotal element in all neural disorders, be that neurological or psychiatric. In this review, we discuss the role of glia in homeostasis and defence of the nervous system as well as changes in the morpho-functional characteristics of these cells in various disorders.
C1 [Verkhratsky, Alexei] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England.
[Verkhratsky, Alexei] Basque Fdn Sci, Ikerbasque, Achucarro Ctr Neurosci, Bilbao 48011, Spain.
[Verkhratsky, Alexei] Univ Nizhny Novgorod, Nizhnii Novgorod 603022, Russia.
[Parpura, Vladimir] Univ Alabama Birmingham, Evelyn F McKnight Brain Inst, Ctr Glial Biol Med, Dept Neurobiol,Atom Force Microscopy Lab, Birmingham, AL 35294 USA.
[Parpura, Vladimir] Univ Alabama Birmingham, Evelyn F McKnight Brain Inst, Civilan Int Res Ctr, Nanotechnol Lab, Birmingham, AL 35294 USA.
[Parpura, Vladimir] Univ Rijeka, Dept Biotechnol, Rijeka 51000, Croatia.
RP Verkhratsky, A (reprint author), Univ Manchester, Oxford Rd, Manchester M13 9PT, Lancs, England.
EM Alexej.Verkhratsky@manchester.ac.uk; vlad@uab.edu
RI Verkhratsky, Alexei/J-4527-2013
OI Verkhratsky, Alexei/0000-0003-2592-9898
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development [HD078678]; Alzheimer's Research Trust (UK); European
Commission; IKERBASQUE; Nizny Novgorod State University
FX We thank Manoj K Gottipati for comments on a previous version of this
manuscript. VP research is supported by the Eunice Kennedy Shriver
National Institute of Child Health and Human Development (HD078678). AV
was supported by the Alzheimer's Research Trust (UK), by European
Commission, by IKERBASQUE and by a research grant of Nizny Novgorod
State University.
CR Acevedo-Arozena A, 2011, DIS MODEL MECH, V4, P686, DOI 10.1242/dmm.007237
Alexander KS, 2012, PSYCHOPHARMACOLOGY, V220, P627, DOI 10.1007/s00213-011-2539-2
ALEXANDER WS, 1949, BRAIN, V72, P373, DOI 10.1093/brain/72.3.373
Beauquis J, 2014, HIPPOCAMPUS, V24, P257, DOI 10.1002/hipo.22219
Beauquis J, 2013, EXP NEUROL, V239, P28, DOI 10.1016/j.expneurol.2012.09.009
Behrendt G, 2013, GLIA, V61, P273, DOI 10.1002/glia.22432
Braak H, 1998, PROG BRAIN RES, V117, P267
Broe M, 2004, BRAIN, V127, P2214, DOI 10.1093/brain/awh250
Brusilow SW, 2010, NEUROTHERAPEUTICS, V7, P452, DOI 10.1016/j.nurt.2010.05.015
Burda JE, 2014, NEURON, V81, P229, DOI 10.1016/j.neuron.2013.12.034
Bushong EA, 2002, J NEUROSCI, V22, P183
Butterworth RF, 2011, HEPATOLOGY, V53, P1372, DOI 10.1002/hep.24228
Carmignoto G, 2012, GLIA, V60, P1227, DOI 10.1002/glia.22318
Chen SK, 2010, CELL, V141, P775, DOI 10.1016/j.cell.2010.03.055
Coulter DA, 2012, GLIA, V60, P1215, DOI 10.1002/glia.22341
Davalos D, 2005, NAT NEUROSCI, V8, P752, DOI 10.1038/nn1472
De Keyser J, 2008, J NEUROL SCI, V267, P3, DOI 10.1016/j.jns.2007.08.044
Del Rio-Hortega P., 1919, B SOC ESP BIOL, V9, P154
DEL RIO-HORTEGA P, 1921, BIOL SOC ESP BIOL, V21, P64
DEL RIO-HORTEGA P, 1932, CYTOLOGY CELLULAR PA, P482
Du YZ, 2002, J NEUROSCI RES, V68, P647, DOI 10.1002/jnr.10245
ESTRADA-SANCHEZ A M, 2012, BASAL GANGL IN PRESS
Fields RD, 2008, NEUROSCIENTIST, V14, P540, DOI 10.1177/1073858408320294
Gagyi E, 2012, BRAIN PATHOL, V22, P803, DOI 10.1111/j.1750-3639.2012.00595.x
Giaume C, 2007, CELL DEATH DIFFER, V14, P1324, DOI 10.1038/sj.cdd.4402144
Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
Gotz J, 2004, MOL PSYCHIATR, V9, P664, DOI 10.1038/sj.mp.4001508
Götz Jürgen, 2012, Front Physiol, V3, P320, DOI 10.3389/fphys.2012.00320
Gourine AV, 2011, EXP PHYSIOL, V96, P411, DOI 10.1113/expphysiol.2010.053165
Guidetti P, 2007, GLIA, V55, P78, DOI 10.1002/glia.20432
Hanisch UK, 2007, NAT NEUROSCI, V10, P1387, DOI 10.1038/nn1997
Hazell AS, 2009, NEUROCHEM INT, V55, P129, DOI 10.1016/j.neuint.2009.02.020
Hazell AS, 2009, GLIA, V58, P148, DOI DOI 10.1002/GLIA.20908
Kersaitis C, 2004, ACTA NEUROPATHOL, V108, P515, DOI 10.1007/s00401-004-0917-0
Kettenmann H, 2011, PHYSIOL REV, V91, P461, DOI 10.1152/physrev.00011.2010
Kettenmann H, 2013, NEURON, V77, P10, DOI 10.1016/j.neuron.2012.12.023
Kettenmann H, 2013, NEUROGLIA
Kettenmann H, 2008, TRENDS NEUROSCI, V31, P653, DOI 10.1016/j.tins.2008.09.003
Kierdorf K, 2013, NAT NEUROSCI, V16, P273, DOI 10.1038/nn.3318
Kondziella D, 2007, NEUROCHEM INT, V50, P291, DOI 10.1016/j.neuint.2006.09.006
Korsakoff S. S, 1955, NEUROLOGY, V32, P3
Korsakoff SS, 1955, NEUROLOGY, V5, P394
Kuchibhotla KV, 2009, SCIENCE, V323, P1211, DOI 10.1126/science.1169096
Kulijewicz-Nawrot M, 2012, J ANAT, V221, P252, DOI 10.1111/j.1469-7580.2012.01536.x
Lee W, 2013, NEUROBIOL DIS, V58, P192, DOI 10.1016/j.nbd.2013.06.002
LENHOSSEK MV, 1895, FEINERE BAU NERVENSY
Lin JHC, 1998, NAT NEUROSCI, V1, P494, DOI 10.1038/2210
Maezawa I, 2010, J NEUROSCI, V30, P5346, DOI 10.1523/JNEUROSCI.5966-09.2010
Maezawa I, 2009, J NEUROSCI, V29, P5051, DOI [10.1523/JNEUROSCI.0324-09.2009, 10.1523/JNEUROSCI.324-09.2009]
McGeer PL, 2008, MOVEMENT DISORD, V23, P474, DOI 10.1002/mds.21751
Messing A, 2012, J NEUROSCI, V32, P5017, DOI 10.1523/JNEUROSCI.5384-11.2012
Nimmerjahn A, 2005, SCIENCE, V308, P1314, DOI 10.1126/science.1110647
Oberheim NA, 2008, J NEUROSCI, V28, P3264, DOI 10.1523/JNEUROSCI.4980-07.2008
Olabarria M, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-55
Olabarria M, 2010, GLIA, V58, P831, DOI 10.1002/glia.20967
Parpura V, 2012, J NEUROCHEM, V121, P4, DOI 10.1111/j.1471-4159.2012.07664.x
Pekna Marcela, 2012, Cerebrum, V2012, P9
Pekny M, 2005, GLIA, V50, P427, DOI 10.1002/glia.20207
Pekny M, 2014, NEUROSCI LETT
Peters O, 2009, J ALZHEIMERS DIS, V18, P177, DOI 10.3233/JAD-2009-1140
Pfrieger FW, 2010, BRAIN RES REV, V63, P39, DOI 10.1016/j.brainresrev.2009.11.002
Potts R, 2005, CLIN NEUROPATHOL, V24, P271
Ransohoff RM, 2009, ANNU REV IMMUNOL, V27, P119, DOI 10.1146/annurev.immunol.021908.132528
Robel S, 2011, NAT REV NEUROSCI, V12, P88, DOI 10.1038/nrn2978
Rodriguez JJ, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.194
RODRIGUEZ J J, 2013, BRAIN STRUCT FUNCT
Rodriguez JJ, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2009.2
Rodriguez JJ, 2009, CELL DEATH DIFFER, V16, P378, DOI 10.1038/cdd.2008.172
Rodriguez JJ, 2011, MOL NEUROBIOL, V43, P87, DOI 10.1007/s12035-010-8157-x
Rose CF, 2013, BIOCHEM SOC T, V41, P1518, DOI 10.1042/BST20130237
Rosenbaum AI, 2011, J NEUROCHEM, V116, P789, DOI 10.1111/j.1471-4159.2010.06976.x
Rossi D, 2008, CELL DEATH DIFFER, V15, P1691, DOI 10.1038/cdd.2008.99
RUSH T, 2014, CELL TISSUE RES
Schwarcz R, 2007, SCHIZOPHRENIA BULL, V33, P652, DOI 10.1093/schbul/sbm030
Seifert G, 2010, BRAIN RES REV, V63, P212, DOI 10.1016/j.brainresrev.2009.10.004
SEIFERT G, 2011, EXP NEUROL
Selkoe DJ, 2001, PHYSIOL REV, V81, P741
Skaper SD, 2010, CNS NEUROL DISORD-DR, V9, P455
Sofroniew MV, 2010, ACTA NEUROPATHOL, V119, P7, DOI 10.1007/s00401-009-0619-8
Sofroniew MV, 2009, TRENDS NEUROSCI, V32, P638, DOI 10.1016/j.tins.2009.08.002
Staats KA, 2009, J BIOL PHYS, V35, P337, DOI 10.1007/s10867-009-9141-4
STALLCUP WB, 1981, DEV BIOL, V83, P154, DOI 10.1016/S0012-1606(81)80018-8
Steiner J, 2012, WORLD J BIOL PSYCHIA, V13, P482, DOI 10.3109/15622975.2011.583941
Struys-Ponsar C, 2000, EXP NEUROL, V163, P157, DOI 10.1006/exnr.2000.7355
Suarez-Fernandez MB, 1999, BRAIN RES, V835, P125, DOI 10.1016/S0006-8993(99)01536-X
Suh SW, 2007, J PHARMACOL EXP THER, V321, P45, DOI 10.1124/jpet.106.115550
Takano T, 2009, STROKE, V40, pS8, DOI 10.1161/STROKEAHA.108.533166
Tanaka J, 1999, GLIA, V28, P85, DOI 10.1002/(SICI)1098-1136(199911)28:2<85::AID-GLIA1>3.0.CO;2-Y
Tierney E, 2006, AM J MED GENET B, V141B, P666, DOI 10.1002/ajmg.b.30368
Tripathi RB, 2010, J NEUROSCI, V30, P16383, DOI 10.1523/JNEUROSCI.3411-10.2010
Vangeison G, 2009, NEUROSCIENTIST, V15, P579, DOI 10.1177/1073858409332405
Verkhratsky A., 2013, NEUROSCIENTIST
VERKHRATSKY A, 2010, NEUROTHERAP IN PRESS
Verkhratsky A, 2013, FUTURE NEUROL, V8, P149, DOI DOI 10.2217/FNL.12.90
Verkhratsky A, 2013, GLIAL PHYSL PATHOPHY
Virchow R., 1858, CELLULARPATHOLOGIE I
Virchow R, 1856, GESAMMELTE ABHANDLUN
Wang LJ, 2011, HUM MOL GENET, V20, P286, DOI 10.1093/hmg/ddq463
Wei HE, 2012, INT J DEV NEUROSCI, V30, P554, DOI 10.1016/j.ijdevneu.2012.08.007
WERNICKE C, 1881, LEHRBUCH GEHIMKRANKH
Yamanaka K, 2008, NAT NEUROSCI, V11, P251, DOI 10.1038/nn2047
Yamazaki Y, 2010, NEUROSCIENTIST, V16, P11, DOI 10.1177/1073858409334425
Yeh CY, 2011, ASN NEURO, V3, DOI 10.1042/AN20110025
Yin ZB, 2007, BRAIN RES, V1131, P1, DOI 10.1016/j.brainres.2006.10.070
Zawadzka M, 2010, CELL STEM CELL, V6, P578, DOI 10.1016/j.stem.2010.04.002
Zeidan-Chulia F, 2014, NEUROSCI BIOBEHAV R, V38, P160, DOI 10.1016/j.neubiorev.2013.11.008
Zhao YX, 2010, NEUROTHERAPEUTICS, V7, P439, DOI 10.1016/j.nurt.2010.07.004
NR 107
TC 1
Z9 1
PU PERIODICUM BIOLOGORUM
PI ZAGREB
PA HRVATSKO PRIRODOSLOVNO DRUSTVO ILICA 16/111, 41000 ZAGREB, CROATIA
SN 0031-5362
J9 PERIOD BIOL
JI Period. Biol.
PD JUN
PY 2014
VL 116
IS 2
BP 115
EP 124
PG 10
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AO5SV
UT WOS:000341406500001
ER
PT J
AU Levey, EJ
AF Levey, Elizabeth J.
TI EFFECTIVE TREATMENT STRATEGIES FOR AUTISM DURING THE FIRST FIVE YEARS OF
DEVELOPMENT
SO JOURNAL OF THE AMERICAN PSYCHOANALYTIC ASSOCIATION
LA English
DT Article
ID SPECTRUM DISORDERS
RP Levey, EJ (reprint author), 32 Fruit St, Boston, MA 02114 USA.
EM ejlevey@gmail.com
CR ENGEL GL, 1977, SCIENCE, V196, P129, DOI 10.1126/science.847460
FOLEY G. M., 2006, MENTAL HLTH EARLY IN, P139
FOLEY G. M., 1985, J CHILDREN CONT SOC, V17, P57
Fraiberg S, 1982, Psychoanal Q, V51, P612
FROMMREICHMANN F, 1990, CONTEMP PSYCHOANAL, V26, P305
Green A, 1999, FABRIC AFFECT PSYCHO
Greenspan SI, 2000, PSYCHOANAL INQ, V20, P675, DOI 10.1080/07351692009348916
Schore AN, 2011, PSYCHOANAL DIALOGUES, V21, P75, DOI 10.1080/10481885.2011.545329
Siegel D. J., 2010, MINDSIGHT NEW SCI PE
Stevenson RA, 2014, J NEUROSCI, V34, P691, DOI 10.1523/JNEUROSCI.3615-13.2014
TSAKIRIS E. A., 2000, CLIN PRACTICE GUIDEL, P725
NR 11
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-0651
EI 1941-2460
J9 J AM PSYCHOANAL ASS
JI J. Am. Psychoanal. Assoc.
PD JUN
PY 2014
VL 62
IS 3
BP 475
EP 484
DI 10.1177/0003065114539839
PG 10
WC Psychiatry; Psychology, Psychoanalysis
SC Psychiatry; Psychology
GA AN6PO
UT WOS:000340718100014
ER
PT J
AU Costescu, CA
Vanderborght, B
David, DO
AF Costescu, Cristina A.
Vanderborght, Bram
David, Daniel O.
TI The Effects of Robot-Enhanced Psychotherapy: A Meta-Analysis
SO REVIEW OF GENERAL PSYCHOLOGY
LA English
DT Article
DE robot-enhanced/assisted therapy; psychological outcomes; meta-analysis
ID REALITY EXPOSURE THERAPY; ANXIETY DISORDERS; ELDERLY-PEOPLE; SOCIAL
ROBOTS; CHILDREN; AUTISM; CARE; ASD
AB Through this meta-analysis we aimed to provide an estimation of the overall effect of robot-enhanced therapy on psychological outcome for different populations, to provide average effect sizes on different outcomes, such as cognitive, behavioral and subjective, and to test possible moderators of effect size. From a total of 861 considered studies for this meta-analysis, only 12 were included because of the lack of studies that have reported quantitative data in this area and because of their primary focus on describing the process of robotic development rather than measuring psychological outcomes. We calculated Cohen's d effect sizes for every outcome measure for which sufficient data were reported. The results show that robot-enhanced therapy yielded a medium effect size overall and, specifically on the behavioral level, indicating that 69% of patients in the control groups did worse than the average number of participants in the intervention group. More studies are needed with regard to specific outcomes to prove the efficacy of robot-enhanced therapy, but the overall results clearly support the use of robot-enhanced therapy for different populations.
C1 [Costescu, Cristina A.; David, Daniel O.] Univ Babes Bolyai, Dept Clin Psychol & Psychotherapy, Cluj Napoca 400015, Cluj, Romania.
[Vanderborght, Bram] Vrije Univ Brussel, Robot & Multibody Mech Res Grp, Brussels, Belgium.
[David, Daniel O.] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA.
RP Costescu, CA (reprint author), Univ Babes Bolyai, Dept Clin Psychol & Psychotherapy, 37 Republicii St, Cluj Napoca 400015, Cluj, Romania.
EM popcristina.anamaria@yahoo.com
RI David, Daniel/N-1285-2014
CR Admoni H., 2011, P 33 ANN C COGN SCI, P1983
Bainbridge WA, 2008, 2008 17TH IEEE INTERNATIONAL SYMPOSIUM ON ROBOT AND HUMAN INTERACTIVE COMMUNICATION, VOLS 1 AND 2, P701, DOI 10.1109/ROMAN.2008.4600749
Bainbridge WA, 2011, INT J SOC ROBOT, V3, P41, DOI 10.1007/s12369-010-0082-7
Bartneck C, 2004, 13 IEEE INT WORKSH R, P591
Bekele ET, 2013, IEEE T NEUR SYS REH, V21, P289, DOI 10.1109/TNSRE.2012.2230188
Bemelmans R, 2012, J AM MED DIR ASSOC, V13, P114, DOI 10.1016/j.jamda.2010.10.002
Beran TN, 2013, VACCINE, V31, P2772, DOI 10.1016/j.vaccine.2013.03.056
Besio S, 2008, LECT NOTES COMPUT SC, V5105, P545, DOI 10.1007/978-3-540-70540-6_78
Borenstein M., 2005, COMPREHENSIVE METAAN
Breazeal C., 2004, 2004 IEEE RSJ INT C, V4, P3559, DOI 10.1109/IROS.2004.1389967
Broekens Joost, 2009, Gerontechnology, V8
Burgoon JK, 2000, COMPUT HUM BEHAV, V16, P553, DOI 10.1016/S0747-5632(00)00029-7
Cassell J, 2001, HUMAN FACTORS J HUMA, P396
Costescu C., TRANSYLVANIAN J PSYC
Dario P., 2012, BRIDGING RES AGEING
Dautenhahn K., 1999, P 3 INT COGN TECHN C, V359, P374
Dautenhahn K, 2004, PRAGMAT COGN, V12, P1, DOI DOI 10.1075/PC.12.1.03DAU
David D., 2014, J COGN PSYCHOL, V7, P192
Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
Eurostat, 2010, DEM REP 2010
Feil-Seifer D., 2005, 9 INT C REH ROB ICOR, P465, DOI DOI 10.1109/ICORR.2005.1501143
Han J. H., 2008, J INFORM PROCESSING, V4, P159
Hancock PA, 2011, HUM FACTORS, V53, P517, DOI 10.1177/0018720811417254
Horstmann G., 2012, HUMAN ROBOT INTERACT, P41
Hoyt CL, 2003, PRESENCE-TELEOP VIRT, V12, P183, DOI 10.1162/105474603321640932
Hunter JE, 1990, METHODS METAANALYSIS
Jung Y., 2004, P PRESENCE 2004, P80, DOI DOI 10.1145/1349822.1349866
Kidd CD, 2006, IEEE INT CONF ROBOT, P3972
Kim ES, 2013, J AUTISM DEV DISORD, V43, P1038, DOI 10.1007/s10803-012-1645-2
Kozima H., 2005, IEEE INT WORKSH ROB, P341, DOI [DOI 10.1109/ROMAN.2005.1513802, 10.1109/ROMAN.2005.1513802]
Kwakkel G, 2008, NEUROREHAB NEURAL RE, V22, P111, DOI 10.1177/1545968307305457
Leyzberg D., 2012, P 34 ANN C COGN SCI
Libin AV, 2004, P IEEE, V92, P1789, DOI 10.1109/JPROC.2004.835366
McGough James J, 2009, Psychiatry (Edgmont), V6, P21
Michaud F., 2001, P AM SOC ENG ED ASEE
Mordoch E, 2013, MATURITAS, V74, P14, DOI 10.1016/j.maturitas.2012.10.015
Muresan V., 2012, J TECHNOLOGY HUMAN S, V30, P1, DOI DOI 10.1080/15228835.2011.653290
Opris D, 2012, DEPRESS ANXIETY, V29, P85, DOI 10.1002/da.20910
Park S, 2007, HUM FACTORS, V49, P1054, DOI 10.1518/001872007X24991
Pop CA, 2014, INTERACT STUD, V15, P292, DOI 10.1075/is.15.2.14pop
Pop CA, 2013, J EDUC COMPUT RES, V49, P381, DOI 10.2190/EC.49.3.f
Powers MB, 2008, J ANXIETY DISORD, V22, P561, DOI 10.1016/j.janxdis.2007.04.006
Reger MA, 2009, J CLIN PSYCHOL, V65, P53, DOI 10.1002/jclp.20536
Ricks DJ, 2010, IEEE INT CONF ROBOT, P4354, DOI 10.1109/ROBOT.2010.5509327
Robins B, 2010, 2010 IEEE RO-MAN, P704, DOI 10.1109/ROMAN.2010.5598641
Rosenthal R., 1991, META ANAL PROCEDURES, V6, DOI [10.4135/9781412984997, DOI 10.4135/9781412984997]
Scassellati B, 2012, ANNU REV BIOMED ENG, V14, P275, DOI 10.1146/annurev-bioeng-071811-150036
Simut R., 2012, INT C INN TECHN AUT
Stanton CM, 2008, P 3 ACM IEEE INT C H, P271, DOI 10.1145/1349822.1349858
Takayama L, 2009, 2009 IEEE-RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS, P5495, DOI 10.1109/IROS.2009.5354145
Tanie K., 2002, IEEE RSJ INT C INT R, V2, P1152, DOI 10.1109/IRDS.2002.1043887
Tapus A, 2012, INTERACT STUD, V13, P315, DOI 10.1075/is.13.3.01tap
Thill S., 2012, PALADYN, V3, P209, DOI DOI 10.2478/S13230-013-0107-7
Vanderborght B, 2012, INTERACT STUD, V13, P348, DOI 10.1075/is.13.3.02van
Wada K, 2004, P IEEE, V92, P1780, DOI 10.1109/JPROC.2004.835378
Wainer Joshua, 2007, 16th IEEE International Conference on Robot and Human Interactive Communication
Wood LJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059448
Zanbaka C, 2007, CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS, VOLS 1 AND 2, P1561
NR 58
TC 0
Z9 0
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1089-2680
EI 1939-1552
J9 REV GEN PSYCHOL
JI Rev. Gen. Psychol.
PD JUN
PY 2014
VL 18
IS 2
BP 127
EP 136
DI 10.1037/gpr0000007
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA AN3FQ
UT WOS:000340471200007
ER
PT J
AU Christinaki, E
Vidakis, N
Triantafyllidis, G
AF Christinaki, Eirini
Vidakis, Nikolas
Triantafyllidis, Georgios
TI A Novel Educational Game for teaching Emotion Identification Skills to
Preschoolers with Autism Diagnosis
SO COMPUTER SCIENCE AND INFORMATION SYSTEMS
LA English
DT Article
DE autism; facial emotion recognition; gesture-based interaction; Kinect;
natural user interface
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; COMMUNICATION-SKILLS;
RECOGNITION SKILLS; ASPERGER-SYNDROME; YOUNG-CHILDREN; INTERVENTION;
INDIVIDUALS; PERCEPTION; ADULTS
AB Emotion recognition is essential in human communication and social interaction. Children with autism have been reported to exhibit deficits in understanding and expressing emotions. Those deficits seem to be rather permanent so intervention tools for improving those impairments are desirable. Educational interventions for teaching emotion recognition should occur as early as possible. It is argued that Serious Games can be very effective in the areas of therapy and education for children with autism. However, those computer interventions require considerable skills for interaction. Before the age of 6, most children with autism do not have such basic motor skills in order to manipulate a mouse or a keyboard. Our approach takes account of the specific characteristics of preschoolers with autism and their physical inabilities. By creating an educational computer game, which provides physical interaction with natural user interface (NUT), we aim to support early intervention and to enhance emotion recognition skills.
C1 [Christinaki, Eirini; Vidakis, Nikolas] Technol Educ Inst Crete, Dept Informat Engn, Iraklion, Greece.
[Triantafyllidis, Georgios] Aalborg Univ, Medial Sect, Copenhagen, Denmark.
RP Christinaki, E (reprint author), Technol Educ Inst Crete, Dept Informat Engn, Iraklion, Greece.
EM echrist@ics.forth.gr; nv@ie.teicrete.gr; gt@create.aau.dk
CR Abirached B., 2012, P WORLD C ED MULT HY, P1054
Akamatsu M, 2002, INT J IND ERGONOM, V29, P171, DOI 10.1016/S0169-8141(01)00063-4
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
[Anonymous], 2000, 92419 ISO
Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012
Axelrod S, 2012, BEHAV INTERVENT, V27, P1, DOI 10.1002/bin.1335
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P3567, DOI 10.1098/rstb.2009.0191
Baron-Cohen S, 2007, PSYCHOLOGIST, V20, P76
Bauminger N, 2002, J AUTISM DEV DISORD, V32, P283, DOI 10.1023/A:1016378718278
Bernardini S., 2013, INFORM SCI IN PRESS
Christinaki E., 2013, P 6 BALK C INF, P141
Coulter R. A., 2009, OPTOMETRY VISION DEV, V40, P164
Dailey M.N., 2001, CALIFORNIA FACIAL EX
De Leo G, 2011, J MED SYST, V35, P703, DOI 10.1007/s10916-009-9407-1
Djaouti D., 2011, SERIOUS GAMES EDUTAI, P25
Dodd S., 2004, UNDERSTANDING AUTISM
Douglas S.A., 1999, P ACM C HUM FACT COM, V15, P215, DOI 10.1145/302979.303042
Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003
Ekman P., 1978, FACIAL ACTION CODING
el Kaliouby R., 2006, INT WORKSH WEAR IMPL, P2
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Faja S, 2008, DEV NEUROPSYCHOL, V33, P1, DOI 10.1080/87565640701729573
Finkelstein SL, 2009, IEEE VIRTUAL REALITY 2009, PROCEEDINGS, P249
Franklin A, 2008, J AUTISM DEV DISORD, V38, P1837, DOI 10.1007/s10803-008-0574-6
Franklin A, 2010, DEVELOPMENTAL SCI, V13, P188, DOI 10.1111/j.1467-7687.2009.00869.x
Ganz JB, 2012, EDUC TRAIN AUTISM DE, V47, P176
Golan Ofer, 2010, J Autism Dev Disord, V40, P269, DOI 10.1007/s10803-009-0862-9
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Gomes Erissandra, 2008, Pro Fono, V20, P279
Gonzalez C, 2013, J AUTISM DEV DISORD, V43, P2259, DOI 10.1007/s10803-013-1772-4
Gray C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1, DOI DOI 10.1177/108835769300800101
Grynszpan O, 2008, INT J HUM-COMPUT ST, V66, P628, DOI 10.1016/j.ijhcs.2008.04.001
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Hobson P. R., 1986, J CHILD PSYCHOL PSYC, V27, P321
Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Kaldy Z., 2011, DEVELOPMENTAL SCI, V14, P980
Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
Lane AE, 2010, COMPUT EDUC, V55, P1112, DOI 10.1016/j.compedu.2010.05.008
LeBlanc L. A., 2004, J EARLY INTENSIVE BE, V1, P166
Lerner MD, 2013, DEV COGN NEUROS-NETH, V3, P11, DOI 10.1016/j.dcn.2012.08.005
Lozano J, 2011, COMUNICAR, P139, DOI 10.3916/C36-2011-03-05
MacKenzie IS, 2001, P ACM C HUM FACT COM, P9, DOI 10.1145/365024.365028
Maldonado N., 2010, CHILDHOOD ED, V86, P284
Mesibov GB, 2005, TEACCH APPROACH AUTI
Miranda J. C., 2011, AUTISM SPECTRUM DISO
Mitgutsch K., 2012, P INT C FDN DIG GAM, P121
Moody A. K., 2012, CHILDHOOD ED, V88, P191
Natapov D., 2009, P GRAPH INT MAY, P223
Noor M., WORLD ACAD SCI ENG T, V64, P647
Pajareya Kingkaew, 2012, Journal of the Medical Association of Thailand, V95, P1184
Park J. H., 2012, HUM FACT COMP SYST, P2423
Parsons S., 2011, EUROPEAN J SPECIAL N, V26, P355, DOI [DOI 10.1080/08856257.2011.593831, 10.1080/08856257.2011.593831]
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Peters-Scheffer N, 2011, RES AUTISM SPECT DIS, V5, P60, DOI 10.1016/j.rasd.2010.03.011
Ploog B., 2012, J AUTISM DEV DISORD, P1
Porayska-Pomsta Kaska, 2013, Advances in Computer Entertainment. 10th International Conference, ACE 2013. Proceedings: LNCS 8253, DOI 10.1007/978-3-319-03161-3_34
Prizant BM, 2003, INFANT YOUNG CHILD, V16, P296
Ramdoss S., 2011, J BEHAV ED, V20, P55, DOI 10.1007/s10864-010-9112-7
Reichow B, 2012, J AUTISM DEV DISORD, V42, P512, DOI 10.1007/s10803-011-1218-9
Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
Sitdhisanguan K, 2012, PERS UBIQUIT COMPUT, V16, P143, DOI 10.1007/s00779-011-0382-4
Smith ML, 2005, PSYCHOL SCI, V16, P184, DOI 10.1111/j.0956-7976.2005.00801.x
Stahmer AC, 2011, AUTISM, V15, P625, DOI 10.1177/1362361310392253
Tan Y. H., 2012, OPEN J PSYCHIAT, V2, P33
Tanaka JW, 2012, J CHILD PSYCHOL PSYC, V53, P1259, DOI 10.1111/j.1469-7610.2012.02571.x
Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
Tzanakaki P, 2012, EDUC TRAIN AUTISM DE, V47, P58
Uljarevic M, 2013, J AUTISM DEV DISORD, V43, P1517, DOI 10.1007/s10803-012-1695-5
Wainer AL, 2011, RES AUTISM SPECT DIS, V5, P96, DOI 10.1016/j.rasd.2010.08.002
White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
Williams BT, 2012, J CHILD PSYCHOL PSYC, V53, P1268, DOI 10.1111/j.1469-7610.2012.02593.x
NR 75
TC 0
Z9 0
PU COMSIS CONSORTIUM
PI NOVI SAD
PA UNIV NOVI SAD, FAC TECH SCI, TRG DOSITEJA OBRADOVICA 6, NOVI SAD, 21000,
SERBIA
SN 1820-0214
J9 COMPUT SCI INF SYST
JI Comput. Sci. Inf. Syst.
PD JUN
PY 2014
VL 11
IS 2
BP 723
EP 743
DI 10.2298/CSIS140215039C
PG 21
WC Computer Science, Information Systems; Computer Science, Software
Engineering
SC Computer Science
GA AM7VO
UT WOS:000340077000016
ER
PT J
AU David, D
Matu, SA
David, OA
AF David, Daniel
Matu, Silviu-Andrei
David, Oana Alexandra
TI Robot-Based Psychotherapy: Concepts Development, State of the Art, and
New Directions
SO INTERNATIONAL JOURNAL OF COGNITIVE THERAPY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; REALITY EXPOSURE THERAPY; ANIMAL-ASSISTED
THERAPY; ELDERLY-PEOPLE; ANXIETY DISORDERS; JOINT ATTENTION;
METAANALYSIS; CHILDREN; CARE; IMITATION
AB In this article we propose new concepts and a framework of robot-based psychotherapy (or robotics-based psychotherapy; i.e., Robo-Therapist, Robo-Mediator, Robo-Assistant). We also review the state of the art of the field based on this framework and delineate possible but also needed future developments and integrations in the field. Implications for future research, theory development, and practice are discussed in the context of evidence-based psychotherapy (i.e., cognitive-behavioral therapy/CBT).
C1 [David, Daniel; Matu, Silviu-Andrei; David, Oana Alexandra] Univ Babes Bolyai, R-3400 Cluj Napoca, Romania.
[David, Daniel] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
RP David, D (reprint author), 37 Republicii St, Cluj Napoca 400015, Romania.
EM daniel.david@ubbcluj.ro
RI David, Daniel/N-1285-2014; Gavita, Oana /C-3454-2011
OI Gavita, Oana /0000-0001-8706-1778
CR Banks MR, 2008, J AM MED DIR ASSOC, V9, P173, DOI 10.1016/j.jamda.2007.11.007
Barry L. M., 2004, FOCUS AUTISM OTHER D, V19, P45, DOI DOI 10.1177/10883576040190010601
Beck A. T., 1996, BECK DEPRESSION INVE, V2nd
Beck J. S., 1995, COGNITIVE THERAPY BA
Bemelmans R, 2012, J AM MED DIR ASSOC, V13, P114, DOI 10.1016/j.jamda.2010.10.002
Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019
Breazeal C, 2004, IEEE T SYST MAN CY C, V34, P181, DOI 10.1109/TSMCC.2004.826268
Broekens Joost, 2009, Gerontechnology, V8
Campolo D., 2010, NEW DEVELOP MENTS IN, P686, DOI [10.5772/7595, DOI 10.5772/7595]
Campolo D., 2008, PAPER PRESENTED AT T
Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
Clarke Greg, 2009, Cognitive Behaviour Therapy, V38, P222, DOI 10.1080/16506070802675353
Cristea IA, 2013, J COGN BEHAV PSYCHOT, V13, P291
Crozier S, 2007, J AUTISM DEV DISORD, V37, P1803, DOI 10.1007/s10803-006-0315-7
Csala E., 2012, PAPER PRESENTED AT T
Dautenhahn K., 2002, SOCIALLY INTELLIGENT, P117
Dautenhahn K., 2002, PAPER PRESENTED AT T
David D., 2010, RETMAGIA SI MINUNATE
David D., 2010, RA TIONAL AND IRRATI
David D., 2006, TRATAT DE PSIHOTERAP
David O. A., 2013, DEVELOPMENTS IN TECH
David O. A., 2013, POSTER PRESENTED AT
David O. A., 2013, THE 7TH WORLD CONGRE
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
Duquette A., 2007, AUTON ROBOT, V24, P147
Editorial Staff, 2005, CANADIAN NURSING HOM, V16, P1
Ellis A., 1994, REASON AND EMOTION I
Feil-Seifer D., 2005, PAPER PRESENTED AT T
Feil-Seifer D., 2011, PAPER PRESENTED AT T
Francois D, 2009, INTERACT STUD, V10, P324, DOI 10.1075/is.10.3.04fra
Francois Michaud and Catherine Theberge-Turmel, 2002, SOCIALLY INTELLIGENT, P125
Goris K, 2011, MECHATRONICS, V21, P490, DOI 10.1016/j.mechatronics.2011.01.001
Hakamata Y, 2010, BIOL PSYCHIAT, V68, P982, DOI 10.1016/j.biopsych.2010.07.021
Hallion LS, 2011, PSYCHOL BULL, V137, P940, DOI 10.1037/a0024355
Kenny P., 2008, PAPER PRESENTED AT 1, DOI [10.1145/1389586.1389594, DOI 10.1145/1389586.1389594]
Kimura R., 2010, PAPER PRESENTED AT T
Klamer T., 2010, PAPER PRESENTED AT T
Libin Alexander, 2004, Am J Alzheimers Dis Other Demen, V19, P111, DOI 10.1177/153331750401900209
Libin AV, 2004, P IEEE, V92, P1789, DOI 10.1109/JPROC.2004.835366
Lupu V, 2009, J COGN BEHAV PSYCHOT, V9, P95
Luxton DD, 2011, PROF PSYCHOL-RES PR, V42, P505, DOI 10.1037/a0024485
Ly KH, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-62
Merrifield C., 1979, CALL ME RET MAN AND
Mordoch E, 2013, MATURITAS, V74, P14, DOI 10.1016/j.maturitas.2012.10.015
Morris ME, 2010, J MED INTERNET RES, V12, DOI 10.2196/jmir.1371
Muresan V., 2012, J TECHNOLOGY HUMAN S, V30, P1, DOI DOI 10.1080/15228835.2011.653290
Nimer J, 2007, ANTHROZOOS, V20, P225, DOI 10.2752/089279307X224773
ODELL JW, 1984, J CLIN PSYCHOL, V40, P942, DOI 10.1002/1097-4679(198407)40:4<942::AID-JCLP2270400412>3.0.CO;2-D
Odetti L., 2007, PAPER PRESENTED AT T
Opris D, 2012, DEPRESS ANXIETY, V29, P85, DOI 10.1002/da.20910
Pierno AC, 2008, NEUROPSYCHOLOGIA, V46, P448, DOI 10.1016/j.neuropsychologia.2007.08.020
Pontier M, 2008, LECT NOTES COMPUT SC, V5208, P417
Powers MB, 2008, J ANXIETY DISORD, V22, P561, DOI 10.1016/j.janxdis.2007.04.006
Preziosa A, 2009, BRIT J GUID COUNS, V37, P313, DOI 10.1080/03069880902957031
Reger MA, 2009, J CLIN PSYCHOL, V65, P53, DOI 10.1002/jclp.20536
Saldien J, 2010, INT J SOC ROBOT, V2, P377, DOI 10.1007/s12369-010-0067-6
Scassellati B, 2007, SPR TRA ADV ROBOT, V28, P552
Scassellati B., 2005, PAPER PRESENTED AT T
Scassellati B, 2012, ANNU REV BIOMED ENG, V14, P275, DOI 10.1146/annurev-bioeng-071811-150036
Scattone D., 2006, FOCUS AUTISM OTHER D, V21, P211, DOI DOI 10.1177/10883576060210040201
Szasz PL, 2011, BEHAV RES THER, V49, P114, DOI 10.1016/j.brat.2010.11.011
Tamura T, 2004, J GERONTOL A-BIOL, V59, P83
Tapus A., 2009, PAPER PRESENTED AT T
Tapus A, 2012, INTERACT STUD, V13, P315, DOI 10.1075/is.13.3.01tap
Tapus A, 2007, IEEE ROBOT AUTOM MAG, V14, P35, DOI 10.1109/MRA.2007.339605
TNS Opinion & Social, 2012, SPECIAL EUROBAROM ET
Vanderborght B, 2012, INTERACT STUD, V13, P348, DOI 10.1075/is.13.3.02van
Wada K, 2008, IEEE ENG MED BIOL, V27, P53, DOI 10.1109/MEMB.2008.919496
Wada K., 2005, PAPER PRESENTED AT T
Wada K., 2007, PAPER PRESENTED AT T
Wada K, 2007, IEEE T ROBOT, V23, P972, DOI 10.1109/TRO.2007.906261
Wada K, 2004, P IEEE, V92, P1780, DOI 10.1109/JPROC.2004.835378
Wada K., 2008, GERONTECHNOLOGY, V7, P235
Wada K., 2009, PAPER PRESENTED AT T
Wainer J., 2010, PAPER PRESENTED AT T
Werry I., 2001, PAPER PRESENTED AT T
Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
NR 78
TC 0
Z9 0
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 1937-1209
EI 1937-1217
J9 INT J COGN THER
JI Int. J. Cogn. Ther.
PD JUN
PY 2014
VL 7
IS 2
BP 192
EP 210
PG 19
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AM1NI
UT WOS:000339612800008
ER
PT J
AU Sidorov, MS
Krueger, DD
Taylor, M
Gisin, E
Osterweil, EK
Bear, MF
AF Sidorov, M. S.
Krueger, D. D.
Taylor, M.
Gisin, E.
Osterweil, E. K.
Bear, M. F.
TI Extinction of an instrumental response: a cognitive behavioral assay in
Fmr1 knockout mice
SO GENES BRAIN AND BEHAVIOR
LA English
DT Article
DE Fragile X; instrumental extinction; intellectual disability; lovastatin;
metabotropic glutamate receptor 5
ID FRAGILE-X-SYNDROME; MENTAL-RETARDATION PROTEIN; MOUSE MODEL; KO MICE;
MGLUR5; DYSFUNCTION; TRANSLATION; LOVASTATIN; RELAPSE
AB Fragile X (FX) is the most common genetic cause of intellectual disability and autism. Previous studies have shown that partial inhibition of metabotropic glutamate receptor signaling is sufficient to correct behavioral phenotypes in a mouse model of FX, including audiogenic seizures, open-field hyperactivity and social behavior. These phenotypes model well the epilepsy (15%), hyperactivity (20%) and autism (30%) that are comorbid with FX in human patients. Identifying reliable and robust mouse phenotypes to model cognitive impairments is critical considering the 90% comorbidity of FX and intellectual disability. Recent work characterized a five-choice visuospatial discrimination assay testing cognitive flexibility, in which FX model mice show impairments associated with decreases in synaptic proteins in prefrontal cortex (PFC). In this study, we sought to determine whether instrumental extinction, another process requiring PFC, is altered in FX model mice, and whether downregulation of metabotropic glutamate receptor signaling pathways is sufficient to correct both visuospatial discrimination and extinction phenotypes. We report that instrumental extinction is consistently exaggerated in FX model mice. However, neither the extinction phenotype nor the visuospatial discrimination phenotype is corrected by approaches targeting metabotropic glutamate receptor signaling. This work describes a novel behavioral extinction assay to model impaired cognition in mouse models of neurodevelopmental disorders, provides evidence that extinction is exaggerated in the FX mouse model and suggests possible limitations of metabotropic glutamate receptor-based pharmacotherapy.
C1 [Sidorov, M. S.; Krueger, D. D.; Taylor, M.; Gisin, E.; Osterweil, E. K.; Bear, M. F.] MIT, Picower Inst Learning & Memory, Cambridge, MA 02139 USA.
RP Bear, MF (reprint author), MIT, Picower Inst Learning & Memory, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM mbear@mit.edu
FU Fraxa Research Foundation; Autism Science Foundation; National Institute
of Mental Health [2T32MH074249]; National Institute of Child Health and
Development [5RO1HD046903]
FX This research was supported by grants from the Fraxa Research
Foundation, Autism Science Foundation, National Institute of Mental
Health training grant 2T32MH074249, and National Institute of Child
Health and Development grant 5RO1HD046903. We thank Dawna Bagherian for
her contributions in testing performance on the visuospatial
discrimination assay. M. F. B. holds patents on the use of mGluR-based
pharmacotherapy for the treatment of fragile X syndrome.
CR Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Bouton ME, 2002, BIOL PSYCHIAT, V52, P976, DOI 10.1016/S0006-3223(02)01546-9
Chesworth R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068371
Cleva RM, 2011, BEHAV NEUROSCI, V125, P10, DOI 10.1037/a0022339
Cleva RM, 2010, CURR NEUROPHARMACOL, V8, P394, DOI 10.2174/157015910793358169
BAKKER CE, 1994, CELL, V78, P23
de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002
DHooge R, 1997, NEUROSCIENCE, V76, P367, DOI 10.1016/S0306-4522(96)00224-2
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Gass JT, 2009, BIOL PSYCHIAT, V65, P717, DOI 10.1016/j.biopsych.2008.11.001
Klanker M, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00201
Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005
Kramvis I, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00172
Krueger DD, 2011, P NATL ACAD SCI USA, V108, P2587, DOI 10.1073/pnas.1013855108
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
Kufahl PR, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00194
Laggerbauer B, 2001, HUM MOL GENET, V10, P329, DOI 10.1093/hmg/10.4.329
Levenga J, 2011, NEUROBIOL DIS, V42, P311, DOI 10.1016/j.nbd.2011.01.022
Li ZZ, 2001, NUCLEIC ACIDS RES, V29, P2276, DOI 10.1093/nar/29.11.2276
Lu YM, 1997, J NEUROSCI, V17, P5196
Michalon A., 2013, BIOL PSYCHIAT, V75, P189
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Millan EZ, 2011, BEHAV BRAIN RES, V217, P454, DOI 10.1016/j.bbr.2010.10.037
Mineur YS, 2002, HIPPOCAMPUS, V12, P39, DOI 10.1002/hipo.10005
Moon J, 2006, BEHAV NEUROSCI, V120, P1367, DOI 10.1037/0735-7044.120.6.1367
Oddi D, 2013, BEHAV BRAIN RES, V251, P75, DOI 10.1016/j.bbr.2013.01.002
Osterweil EK, 2010, J NEUROSCI, V30, P15616, DOI 10.1523/JNEUROSCI.3888-10.2010
Osterweil EK, 2013, NEURON, V77, P243, DOI 10.1016/j.neuron.2012.01.034
Qin M, 2005, J NEUROSCI, V25, P5087, DOI 10.1523/JNEUROSCI.0093-05.2005
Rebec GV, 2005, J EXP ANAL BEHAV, V84, P653, DOI 10.1901/jeab.2005.105-04
Schneider A, 2009, DEV DISABIL RES REV, V15, P333, DOI 10.1002/ddrr.80
Veloz MFV, 2012, GENES BRAIN BEHAV, V11, P325, DOI 10.1111/j.1601-183X.2011.00763.x
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Yamada T, 2000, J INHERIT METAB DIS, V23, P607, DOI 10.1023/A:1005634130286
Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
Yan QJ, 2004, GENES BRAIN BEHAV, V3, P337, DOI 10.1111/j.1601-183X.2004.00087.x
Yu HL, 2010, INT J DEV NEUROSCI, V28, P271, DOI 10.1016/j.ijdevneu.2009.12.001
NR 37
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1601-1848
EI 1601-183X
J9 GENES BRAIN BEHAV
JI Genes Brain Behav.
PD JUN
PY 2014
VL 13
IS 5
BP 451
EP 458
DI 10.1111/gbb.12137
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AL8JE
UT WOS:000339383600001
ER
PT J
AU van Rijn, S
Stockmann, L
van Buggenhout, G
van Ravenswaaij-Arts, C
Swaab, H
AF van Rijn, S.
Stockmann, L.
van Buggenhout, G.
van Ravenswaaij-Arts, C.
Swaab, H.
TI Social cognition and underlying cognitive mechanisms in children with an
extra X chromosome: a comparison with autism spectrum disorder
SO GENES BRAIN AND BEHAVIOR
LA English
DT Article
DE Autism; facial expressions; Klinefelter; theory of mind; Trisomy X
ID KLINEFELTER-SYNDROME; HIGH-RISK; MIND; SCHIZOPHRENIA; LANGUAGE; BOYS;
XYY; XXY; ABNORMALITIES; METAANALYSIS
AB Individuals with an extra X chromosome are at increased risk for autism symptoms. This study is the first to assess theory of mind and facial affect labeling in children with an extra X chromosome. Forty-six children with an extra X chromosome (29 boys with Klinefelter syndrome and 17 girls with Trisomy X), 56 children with autism spectrum disorder (ASD) and 88 non-clinical controls, aged 9-18 years, were included. Similar to children with ASD, children with an extra X chromosome showed significant impairments in social cognition. Regression analyses showed that different cognitive functions predicted social cognitive skills in the extra X and ASD groups. The social cognitive deficits were similar for boys and girls with an extra X chromosome, and not specific for a subgroup with high Autism Diagnostic Interview Revised autism scores. Thus, children with an extra X chromosome show social cognitive deficits, which may contribute to social dysfunction, not only in children showing a developmental pattern that is 'typical' for autism but also in those showing mild or late presenting autism symptoms. Our findings may also help explain variance in type of social deficit: children may show similar social difficulties, but these may arise as a consequence of different underlying information processing deficits.
C1 [van Rijn, S.; Stockmann, L.; Swaab, H.] Leiden Univ, NL-2333 AK Leiden, Netherlands.
[van Rijn, S.; Swaab, H.] Leiden Inst Brain & Cognit, Leiden, Netherlands.
[Stockmann, L.] Autism Ctr Rivierduinen, Leiden, Netherlands.
[van Buggenhout, G.] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium.
[van Ravenswaaij-Arts, C.] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
RP van Rijn, S (reprint author), Leiden Univ, Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.
EM srijn@fsw.leidenuniv.nl
FU VENI grant from the Netherlands Organization for Scientific Research
(NWO) [016.095.060]
FX This work was supported by a VENI grant (grant number 016.095.060 to
SvR) from the Netherlands Organization for Scientific Research (NWO).
CR Achenbach TM, 1991, MANUAL CHILD BEHAV C
Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Apperly IA, 2005, TRENDS COGN SCI, V9, P572, DOI 10.1016/j.tics.2005.10.004
Astington JW, 1999, DEV PSYCHOL, V35, P1311, DOI 10.1037//0012-1649.35.5.1311
Beauchamp MH, 2010, PSYCHOL BULL, V136, P39, DOI 10.1037/a0017768
Bender BG, 1999, AM J MED GENET, V88, P200, DOI 10.1002/(SICI)1096-8628(19990416)88:2<200::AID-AJMG18>3.0.CO;2-3
Bishop DVM, 2011, ARCH DIS CHILD, V96, P954, DOI 10.1136/adc.2009.179747
Boone KB, 2001, J INT NEUROPSYCH SOC, V7, P446, DOI 10.1017/S1355617701744013
Bora E, 2013, SCHIZOPHR RES, V144, P31, DOI 10.1016/j.schres.2012.12.013
Brandenburg-Goddard M. N., 2014, SOC COGN AFFECT NEUR, V9
Bruining H, 2009, PEDIATRICS, V123, pE865, DOI 10.1542/peds.2008-1954
Campbell JM, 1998, PSYCHOL ASSESSMENT, V10, P431, DOI 10.1037/1040-3590.10.4.431
Coleman Naomi, 2008, J Intellect Disabil, V12, P49, DOI 10.1177/1744629507086608
Cordeiro L, 2012, RES DEV DISABIL, V33, P1254, DOI 10.1016/j.ridd.2012.02.013
De Sonneville L. M. J., 2005, TIJDSCHRIFT NEUROPSY, P27
Dennis M, 2009, J CLIN EXP NEUROPSYC, V31, P835, DOI 10.1080/13803390802572419
de Sonneville LMJ, 1999, COMP PSYCH, V6, P187
Garfield JL, 2001, MIND LANG, V16, P494, DOI 10.1111/1468-0017.00180
Geschwind D.H., 2004, LEARNING DISABILITIE, V19, P166, DOI 10.1111/j.1540-5826.2004.00100.x
Gopnik A., 1994, CHILDRENS EARLY UNDE, P157
Harmon RJ, 1998, J AM ACAD CHILD PSY, V37, P286, DOI 10.1097/00004583-199803000-00013
HerreraGraf M, 1996, EDUC PSYCHOL MEAS, V56, P522, DOI 10.1177/0013164496056003014
Hooker C, 2002, PSYCHIAT RES, V112, P41, DOI 10.1016/S0165-1781(02)00177-4
van 't Wout M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005581
Kaufman AS, 1983, KAUFMAN ASSESSMENT B
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Milligan K, 2007, CHILD DEV, V78, P622, DOI 10.1111/j.1467-8624.2007.01018.x
Miranda-Casas A, 2013, REV NEUROLOGIA, V57, pS177
Ratcliffe S, 1999, ARCH DIS CHILD, V80, P192
RATCLIFFE SG, 1991, BIRTH DEF, V26, P1
ROBINSON A, 1991, BIRTH DEF, V26, P59
Rommelse NNJ, 2008, PSYCHOL MED, V38, P1595, DOI 10.1017/S0033291708002869
Ross JL, 2012, PEDIATRICS, V129, P769, DOI 10.1542/peds.2011-0719
Schuitema I, 2013, J CLIN ONCOL, V31, P3378, DOI 10.1200/JCO.2012.46.7050
Semel E., 2003, CLIN EVALUATION LANG, V4th
Serra M, 2003, J AUTISM DEV DISORD, V33, P303, DOI 10.1023/A:1024458618172
Stewart D A, 1990, Birth Defects Orig Artic Ser, V26, P131
Tartaglia Nicole, 2010, Pediatr Endocrinol Rev, V8 Suppl 1, P151
Tartaglia N.R., 2010, ORPHANET J RARE DIS, V5, P9
van Bon W.H.J., 1982, MANUAL LANGUAGE TEST
Van Manen T.G., 2009, MANUAL SOCIAL COGNIT
van Rijn S, 2014, J AUTISM DEV DISORD, V44, P310, DOI 10.1007/s10803-013-1860-5
van Rijn S, 2007, J INT NEUROPSYCH SOC, V13, P1065, DOI 10.1017/S1355617707071044
van Rijn S, 2006, SCHIZOPHR RES, V84, P194, DOI 10.1016/j.schres.2006.02.020
van Rijn S, 2008, J AUTISM DEV DISORD, V38, P1634, DOI 10.1007/s10803-008-0542-1
Visootsak J, 2009, DEV DISABIL RES REV, V15, P328, DOI 10.1002/ddrr.76
Wechsler D., 2003, WECHSLER INTELLIGENC
NR 48
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1601-1848
EI 1601-183X
J9 GENES BRAIN BEHAV
JI Genes Brain Behav.
PD JUN
PY 2014
VL 13
IS 5
BP 459
EP 467
DI 10.1111/gbb.12134
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AL8JE
UT WOS:000339383600002
ER
PT J
AU Olson, H
Shen, YP
Avallone, J
Sheidley, BR
Pinsky, R
Bergin, AM
Berry, GT
Duffy, FH
Eksioglu, Y
Harris, DJ
Hisama, FM
Ho, E
Irons, M
Jacobsen, CM
James, P
Kothare, S
Khwaja, O
Lipton, J
Loddenkemper, T
Markowitz, J
Maski, K
Megerian, JT
Neilan, E
Raffalli, PC
Robbins, M
Roberts, A
Roe, E
Rollins, C
Sahin, M
Sarco, D
Schonwald, A
Smith, SE
Soul, J
Stoler, JM
Takeoka, M
Tan, WH
Torres, AR
Tsai, P
Urion, DK
Weissman, L
Wolff, R
Wu, BL
Miller, DT
Poduri, A
AF Olson, Heather
Shen, Yiping
Avallone, Jennifer
Sheidley, Beth R.
Pinsky, Rebecca
Bergin, Ann M.
Berry, Gerard T.
Duffy, Frank H.
Eksioglu, Yaman
Harris, David J.
Hisama, Fuki M.
Ho, Eugenia
Irons, Mira
Jacobsen, Christina M.
James, Philip
Kothare, Sanjeev
Khwaja, Omar
Lipton, Jonathan
Loddenkemper, Tobias
Markowitz, Jennifer
Maski, Kiran
Megerian, J. Thomas
Neilan, Edward
Raffalli, Peter C.
Robbins, Michael
Roberts, Amy
Roe, Eugene
Rollins, Caitlin
Sahin, Mustafa
Sarco, Dean
Schonwald, Alison
Smith, Sharon E.
Soul, Janet
Stoler, Joan M.
Takeoka, Masanori
Tan, Wen-Han
Torres, Alcy R.
Tsai, Peter
Urion, David K.
Weissman, Laura
Wolff, Robert
Wu, Bai-Lin
Miller, David T.
Poduri, Annapurna
TI Copy Number Variation Plays an Important Role in Clinical Epilepsy
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID IDIOPATHIC GENERALIZED EPILEPSY; CONTIGUOUS-GENE-SYNDROME;
COMPARATIVE-GENOMIC-HYBRIDIZATION; FAMILIAL NEONATAL SEIZURES; AUTISM
SPECTRUM DISORDERS; SEVERE MYOCLONIC EPILEPSY; INTELLECTUAL DISABILITY;
CHROMOSOMAL MICROARRAY; 15Q13.3 MICRODELETIONS; MOLECULAR
CHARACTERIZATION
AB Objective: To evaluate the role of copy number abnormalities detectable using chromosomal microarray (CMA) testing in patients with epilepsy at a tertiary care center.
Methods: We identified patients with International Classification of Diseases, ninth revision (ICD-9) codes for epilepsy or seizures and clinical CMA testing performed between October 2006 and February 2011 at Boston Children's Hospital. We reviewed medical records and included patients who met criteria for epilepsy. We phenotypically characterized patients with epilepsy-associated abnormalities on CMA.
Results: Of 973 patients who had CMA and ICD-9 codes for epilepsy or seizures, 805 patients satisfied criteria for epilepsy. We observed 437 copy number variants (CNVs) in 323 patients (1-4 per patient), including 185 (42%) deletions and 252 (58%) duplications. Forty (9%) were confirmed de novo, 186 (43%) were inherited, and parental data were unavailable for 211 (48%). Excluding full chromosome trisomies, CNV size ranged from 18kb to 142Mb, and 34% were >500kb. In at least 40 cases (5%), the epilepsy phenotype was explained by a CNV, including 29 patients with epilepsy-associated syndromes and 11 with likely disease-associated CNVs involving epilepsy genes or "hotspots." We observed numerous recurrent CNVs including 10 involving loss or gain of Xp22.31, a region described in patients with and without epilepsy.
Interpretation: Copy number abnormalities play an important role in patients with epilepsy. Because the diagnostic yield of CMA for epilepsy patients is similar to the yield in autism spectrum disorders and in prenatal diagnosis, for which published guidelines recommend testing with CMA, we recommend the implementation of CMA in the evaluation of unexplained epilepsy.
C1 [Olson, Heather; Sheidley, Beth R.; Pinsky, Rebecca; Poduri, Annapurna] Boston Childrens Hosp, Dept Neurol, Epilepsy Genet Program, Div Epilepsy & Clin Neurophysiol, Boston, MA 02115 USA.
[Olson, Heather; Sheidley, Beth R.; Pinsky, Rebecca; Poduri, Annapurna] Boston Childrens Hosp, Dept Neurol, Neurogenet Program, Boston, MA 02115 USA.
[Olson, Heather; Avallone, Jennifer; Sheidley, Beth R.; Pinsky, Rebecca; Bergin, Ann M.; Berry, Gerard T.; Duffy, Frank H.; Eksioglu, Yaman; Harris, David J.; Hisama, Fuki M.; Ho, Eugenia; Irons, Mira; Jacobsen, Christina M.; James, Philip; Kothare, Sanjeev; Khwaja, Omar; Lipton, Jonathan; Loddenkemper, Tobias; Markowitz, Jennifer; Maski, Kiran; Megerian, J. Thomas; Neilan, Edward; Raffalli, Peter C.; Robbins, Michael; Roberts, Amy; Roe, Eugene; Rollins, Caitlin; Sahin, Mustafa; Sarco, Dean; Smith, Sharon E.; Soul, Janet; Stoler, Joan M.; Takeoka, Masanori; Tan, Wen-Han; Torres, Alcy R.; Tsai, Peter; Urion, David K.; Weissman, Laura; Wolff, Robert; Miller, David T.; Poduri, Annapurna] Harvard Univ, Sch Med, Boston, MA USA.
[Shen, Yiping; Wu, Bai-Lin] Boston Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA.
[Shen, Yiping; Wu, Bai-Lin] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
[Shen, Yiping; Wu, Bai-Lin; Miller, David T.] Claritas Genom Inc, Cambridge, MA USA.
[Avallone, Jennifer; Bergin, Ann M.; Duffy, Frank H.; Eksioglu, Yaman; Loddenkemper, Tobias; Sarco, Dean; Takeoka, Masanori] Boston Childrens Hosp, Div Epilepsy & Clin Neurophysiol, Dept Neurol, Boston, MA 02115 USA.
[Berry, Gerard T.; Harris, David J.; Hisama, Fuki M.; Irons, Mira; Jacobsen, Christina M.; James, Philip; Neilan, Edward; Roberts, Amy; Smith, Sharon E.; Stoler, Joan M.; Tan, Wen-Han; Miller, David T.] Boston Childrens Hosp, Div Genet & Genom, Boston, MA 02115 USA.
[Hisama, Fuki M.] Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA.
[Ho, Eugenia; Khwaja, Omar; Lipton, Jonathan; Markowitz, Jennifer; Maski, Kiran; Megerian, J. Thomas; Raffalli, Peter C.; Robbins, Michael; Roe, Eugene; Rollins, Caitlin; Sahin, Mustafa; Soul, Janet; Torres, Alcy R.; Tsai, Peter; Urion, David K.; Wolff, Robert] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA.
[Ho, Eugenia] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Dept Neurol, Los Angeles, CA 90033 USA.
[Jacobsen, Christina M.] Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.
[Kothare, Sanjeev] NYU, Dept Neurol, New York, NY 10016 USA.
[Roberts, Amy] Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA.
[Schonwald, Alison; Torres, Alcy R.] Boston Univ, Boston Med Ctr, Dept Pediat, Boston, MA 02215 USA.
[Schonwald, Alison; Torres, Alcy R.] Boston Univ, Boston Med Ctr, Dept Neurol, Boston, MA 02215 USA.
[Weissman, Laura] Boston Childrens Hosp, Div Dev Med, Boston, MA 02115 USA.
RP Poduri, A (reprint author), Boston Childrens Hosp, Fegan 9,300 Longwood Ave, Boston, MA 02115 USA.
EM annapurna.poduri@childrens.harvard.edu
FU NIH National Institute of Neurologic Disorders and Stroke [1K23NS069784,
5K12NS079414-02]; NIH National Human Genome Research Institute
FX This study was supported by the NIH National Institute of Neurologic
Disorders and Stroke (1K23NS069784, A. P.; 5K12NS079414-02, H.O.) and
NIH National Human Genome Research Institute (D.T.M.).
CR BALLABIO A, 1989, ANN HUM GENET, V53, P9, DOI 10.1111/j.1469-1809.1989.tb01117.x
Bartnik M, 2012, AM J MED GENET B, V159B, P760, DOI 10.1002/ajmg.b.32081
Basel-Vanagaite L, 2011, J CHILD NEUROL, V26, P113, DOI 10.1177/0883073810377658
Battaglia A, 2013, EUR J PAEDIATR NEURO, V17, P589, DOI 10.1016/j.ejpn.2013.04.010
Becker F, 2013, J NEUROL, V260, P1234, DOI 10.1007/s00415-012-6777-y
Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063
Cossette P, 2002, NAT GENET, V31, P184, DOI 10.1038/ng885
Dabell MP, 2013, AM J MED GENET A, V161A, P717, DOI 10.1002/ajmg.a.35780
de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
Dibbens LM, 2009, HUM MOL GENET, V18, P3626, DOI 10.1093/hmg/ddp311
Doherty MJ, 2003, EPILEPSIA, V44, P1529, DOI 10.1111/j.0013-9580.2003.61702.x
Duong L, 2012, AM J MED GENET B, V159B, P354, DOI 10.1002/ajmg.b.32036
Escayg A, 2000, AM J HUM GENET, V66, P1531, DOI 10.1086/302909
Faletra F, 2012, AM J MED GENET A, V158A, P461, DOI 10.1002/ajmg.a.34398
Gohlke BC, 2000, J MED GENET, V37, P600, DOI 10.1136/jmg.37.8.600
Gregor A, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-106
Hannes FD, 2009, J MED GENET, V46, P223, DOI 10.1136/jmg.2007.055202
Harrison V, 2011, AM J MED GENET A, V155A, P2826, DOI 10.1002/ajmg.a.34255
Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
Heron SE, 2007, J MED GENET, V44, P791, DOI 10.1136/jmg.2007.051938
Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
Kurahashi H, 2009, NEUROLOGY, V73, P1214, DOI 10.1212/WNL.0b013e3181bc0158
Kurian MA, 2010, BRAIN, V133, P2964, DOI 10.1093/brain/awq238
Li F, 2010, EUR J MED GENET, V53, P93, DOI 10.1016/j.ejmg.2010.01.004
Liang JS, 2011, EPILEPSIA, V52, P1835, DOI 10.1111/j.1528-1167.2011.03174.x
Macdonald RL, 2012, JASPERS BASIC MECH E
Masurel-Paulet A, 2010, CLIN GENET, V78, P149, DOI 10.1111/j.1399-0004.2010.01374.x
Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
Mefford HC, 2011, ANN NEUROL, V70, P974, DOI 10.1002/ana.22645
MEINDL A, 1993, J MED GENET, V30, P838, DOI 10.1136/jmg.30.10.838
Melichar VO, 2007, AM J MED GENET A, V143A, P135, DOI 10.1002/ajmg.a.31451
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
Milunsky J, 1999, CLIN GENET, V55, P455, DOI 10.1034/j.1399-0004.1999.550610.x
Moller RS, 2013, EPILEPSIA, V54, P256, DOI 10.1111/epi.12078
Muhle H, 2011, EPILEPSIA, V52, pE194, DOI 10.1111/j.1528-1167.2011.03301.x
Mullen SA, 2013, NEUROLOGY, V81, P1507, DOI 10.1212/WNL.0b013e3182a95829
Mulley JC, 2006, NEUROLOGY, V67, P1094, DOI 10.1212/01.wnl.0000237322.04338.2b
Olson H, 2012, J PEDIAT EPILEPSY, V1, P151
Poduri A, 2012, EPILEPSIA, V53, pE146, DOI 10.1111/j.1528-1167.2012.03538.x
Potocki L, 2007, AM J HUM GENET, V80, P633, DOI 10.1086/512864
Puusepp H, 2008, PEDIATR NEUROL, V38, P289, DOI 10.1016/j.pediatrneurol.2007.11.008
Schaaf CP, 2012, EUR J HUM GENET, V20, P1240, DOI 10.1038/ejhg.2012.95
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Shinawi M, 2009, AM J MED GENET A, V149A, P1138, DOI 10.1002/ajmg.a.32833
Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
Spranger S, 1999, AM J MED GENET, V83, P367, DOI 10.1002/(SICI)1096-8628(19990423)83:5<367::AID-AJMG5>3.0.CO;2-K
Striano P, 2012, ARCH NEUROL-CHICAGO, V69, P322, DOI 10.1001/archneurol.2011.1999
Striano P, 2011, NEUROLOGY, V76, P1600, DOI 10.1212/WNL.0b013e3182194bbf
Tobias ES, 2001, J MED GENET, V38, P466, DOI 10.1136/jmg.38.7.466
van Steensel MAM, 2008, AM J MED GENET A, V146A, P2944, DOI 10.1002/ajmg.a.32473
Wang J, 2008, EPILEPSIA, V49, P1528, DOI 10.1111/j.1528-1167.2008.01609.x
Wapner RJ, 2012, NEW ENGL J MED, V367, P2175, DOI 10.1056/NEJMoa1203382
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 56
TC 7
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD JUN
PY 2014
VL 75
IS 6
BP 943
EP 958
DI 10.1002/ana.24178
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AK9UE
UT WOS:000338772200015
PM 24811917
ER
PT J
AU Huang, JP
Cui, SS
Han, Y
Irva, HP
Qi, LH
Zhang, X
AF Huang Jun Ping
Cui Shan Shan
Han Yu
Irva, Hertz-Picciotto
Qi Li Hong
Zhang Xin
TI Prevalence and Early Signs of Autism Spectrum Disorder (ASD) among 18-36
Month Old Children in Tianjin of China
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Article
DE Autism spectrum disorder; Prevalence; Early signs; Discriminant function
analysis
ID PERVASIVE DEVELOPMENTAL DISORDERS; EARLY IDENTIFICATION; SCREENING
INSTRUMENT; MENTAL-RETARDATION; EARLY RECOGNITION; FOLLOW-UP; 2ND YEAR;
DIAGNOSIS; AGE; POPULATION
AB Objective The aim of this study is to estimate the prevalence of autism spectrum disorder (ASD) among 18-36 month old children in the Tianjin Municipality of China, and to identify early signs of autistic children and the predictability of each individual symptom.
Methods A total of 8 000 children were screened to do a questionnaire based on CHAT modified to include more early signs of autism at the age of 18-36 months. Then the at-risk children were reexamined 1.5 years later and ASD children were identified based on DSM-IV. Early signs of autism were analyzed retrospectively by using discriminant function analysis performed among ASD children, children not followed up and children followed up but failing to meet ASD criteria.
Results Three hundred and sixty seven children were screened as being at-risk to ASD, and 22 of them were identified as having ASD in the subsequent diagnosis. The prevalence of ASD was 27.5 per 10 000 in Tianjin of China with a male to female ratio of 4:1. Items addressing social interactions and communications had higher predictability than other items to distinguish autistic children from non-autistic ones. Pretend play, functional play, showing and reading parents' facial expressions distinguished autistic children from those not followed up, nevertheless those followed up but failing to meet ASD criteria were not included.
Conclusion The prevalence of ASD found in our study was lower than that reported in some studies by western researchers. Autism has its specific symptoms, such as deficits in social awareness, social relatedness, and social referencing.
C1 [Huang Jun Ping; Cui Shan Shan; Han Yu; Zhang Xin] Tianjin Med Univ, Sch Publ Hlth, Tianjin 300070, Peoples R China.
[Irva, Hertz-Picciotto; Qi Li Hong] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
RP Zhang, X (reprint author), Tianjin Med Univ, Sch Publ Hlth, Tianjin 300070, Peoples R China.
EM zhangxin@tmu.edu.cn
FU National Natural Science Foundation of China [81072313]
FX The study was support by the National Natural Science Foundation of
China Grant No. 81072313.
CR Adamson LB, 2009, J AUTISM DEV DISORD, V39, P84, DOI 10.1007/s10803-008-0601-7
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
Barbaro J, 2010, J DEV BEHAV PEDIATR, V31, P376, DOI 10.1097/DBP.0b013e3181df7f3c
Barbaro J, 2009, J DEV BEHAV PEDIATR, V30, P447, DOI 10.1097/DBP.0b013e3181ba0f9f
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
BARONCOHEN S, 1996, BRIT J PSYCHIAT, V168, P158, DOI DOI 10.1192/BJP.168.2.158
Baron-Cohen S, 2000, J ROY SOC MED, V93, P521
Bird T.D., 1993, GENEREVIEWS
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
Coplan J, 2000, PEDIATRICS, V105, part. no., DOI 10.1542/peds.105.5.e65
Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488
Crais Elizabeth R., 2006, Seminars in Speech and Language, V27, P143, DOI 10.1055/s-2006-948226
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 2009, PEDIATRICS, V125, pe17, DOI DOI 10.1542/PEDS.2009-0958
Filipek PA, 2000, NEUROLOGY, V55, P468
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Fombonne E, 2006, PEDIATRICS, V118, pE139, DOI 10.1542/peds.2005-2993
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Landa RJ, 2008, NAT CLIN PRACT NEURO, V4, P138, DOI 10.1038/ncpneuro0731
[刘靖 LIU Jing], 2007, [中国心理卫生杂志, Chinese Mental Health Journal], V21, P290
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
Martinez-Pedraza FD, 2009, CHILD ADOL PSYCH CL, V18, P645, DOI 10.1016/j.chc.2009.02.002
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Nadel S, 2007, J AM ACAD NURSE PRAC, V19, P408, DOI 10.1111/j.1745-7599.2007.00244.x
Nygren G, J AUTISM DEV DISORD
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Ozonoff S, 2009, J DEV BEHAV PEDIATR, V30, P367
Rapin I, 2008, PEDIATR CLIN N AM, V55, P1129, DOI 10.1016/j.pcl.2008.07.005
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
Shumway S, 2009, J SPEECH LANG HEAR R, V52, P1139, DOI 10.1044/1092-4388(2009/07-0280)
Stone WL, 2008, AUTISM, V12, P557, DOI 10.1177/1362361308096403
Tebruegge Marc, 2004, BMC Pediatr, V4, P4, DOI 10.1186/1471-2431-4-4
Tianjin Population and Family Planning Commitee, 2010, TIANJ 6 CENS DAT
Ventola P, 2007, J AUTISM DEV DISORD, V37, P425, DOI 10.1007/s10803-006-0177-z
Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159
Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083
Wong V, 2004, PEDIATRICS, V114, P166
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
Young RL, 2003, AUTISM, V7, P125, DOI 10.1177/1362361303007002002
Zhang X, 2005, BIOMED ENVIRON SCI, V18, P334
Zwaigenbaum L, 2010, CURR OPIN NEUROL, V23, P97, DOI 10.1097/WCO.0b013e3283372430
NR 56
TC 0
Z9 0
PU CHINESE CENTER DISEASE CONTROL & PREVENTION
PI BEIJING
PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA
SN 0895-3988
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD JUN
PY 2014
VL 27
IS 6
BP 453
EP 461
DI 10.3967/bes2014.008
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AK9TX
UT WOS:000338771400007
PM 24961855
ER
PT J
AU Chen, CK
Bregere, C
Paluch, J
Lu, JF
Dickman, DK
Chang, KT
AF Chen, Chun-Kan
Bregere, Catherine
Paluch, Jeremy
Lu, Jason F.
Dickman, Dion K.
Chang, Karen T.
TI Activity-dependent facilitation of Synaptojanin and synaptic vesicle
recycling by the Minibrain kinase
SO NATURE COMMUNICATIONS
LA English
DT Article
ID CLATHRIN-MEDIATED ENDOCYTOSIS; NEURAL PROGENITOR CELLS; DOWN-SYNDROME;
NERVE-TERMINALS; NEUROMUSCULAR-JUNCTION; COGNITIVE DEFICITS;
PLASMA-MEMBRANE; ADAPTER PROTEIN; DYNAMIN-I; DYRK1A
AB Phosphorylation has emerged as a crucial regulatory mechanism in the nervous system to integrate the dynamic signalling required for proper synaptic development, function and plasticity, particularly during changes in neuronal activity. Here we present evidence that Minibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum disorder and Down syndrome, is required presynaptically for normal synaptic growth and rapid synaptic vesicle endocytosis at the Drosophila neuromuscular junction (NMJ). We find that Mnb-dependent phosphorylation of Synaptojanin (Synj) is required, in vivo, for complex endocytic protein interactions and to enhance Synj activity. Neuronal stimulation drives Mnb mobilization to endocytic zones and triggers Mnb-dependent phosphorylation of Synj. Our data identify Mnb as a synaptic kinase that promotes efficient synaptic vesicle recycling by dynamically calibrating Synj function at the Drosophila NMJ, and in turn endocytic capacity, to adapt to conditions of high synaptic activity.
C1 [Chen, Chun-Kan; Bregere, Catherine; Lu, Jason F.; Chang, Karen T.] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA.
[Chen, Chun-Kan] Univ So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USA.
[Paluch, Jeremy; Dickman, Dion K.] Univ So Calif, Dept Neurobiol, Los Angeles, CA 90089 USA.
[Chang, Karen T.] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90089 USA.
RP Chang, KT (reprint author), Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA.
EM changkt@usc.edu
FU National Institutes of Health [NS080946]; Jerome Lejeune Foundation;
Alzheimer's Association; Global Down Syndrome Foundation; NIMH [R00
MH092351]; Ellison Medical Foundation
FX We thank Martin Heisenberg (University of Wuzburg, Germany) for the
mnb1 stock. We are grateful to Hugo Bellen (Baylor, TX, USA)
for his generous sharing of UAS-PLC delta 1-PH-GFP flies and multiple
antibodies used in this manuscript, including the Synj antibody that we
renamed here to p-Synj for clarification purposes. We thank Julie
Simpson (HHMI Janelia Farm, VA, USA) for gift of the nSyb-Gal4 stock and
the Developmental Hybridoma Bank (Iowa, USA) for antibodies. We thank
the Proteomics Core at USC for assistance with mass spectrometry data
collection and analyses. We also thank Dr K.-T. Min for critical reading
of the manuscript, John W. Carlson for excellent technical assistance
and members of the Chang laboratory for discussion. This work was
supported by grants from the National Institutes of Health (NS080946),
the Jerome Lejeune Foundation, and Alzheimer's Association and Global
Down Syndrome Foundation to K.T.C., and grants from the NIMH (R00
MH092351) and the Ellison Medical Foundation to D.K.D.
CR Adayev T, 2006, BIOCHEM BIOPH RES CO, V351, P1060, DOI 10.1016/j.bbrc.2006.10.169
Ahn KJ, 2006, NEUROBIOL DIS, V22, P463, DOI 10.1016/j.nbd.2005.12.006
Altafaj X, 2001, HUM MOL GENET, V10, P1915, DOI 10.1093/hmg/10.18.1915
Arai Y, 2002, BRAIN DEV-JPN, V24, P67, DOI 10.1016/S0387-7604(01)00405-3
Arque G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054285
Arque G, 2009, NEUROBIOL DIS, V36, P312, DOI 10.1016/j.nbd.2009.07.027
Arque G, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002575
Broadie K, 2004, CURR BIOL, V14, pR853, DOI 10.1016/j.cub.2004.09.042
Campbell LE, 2002, FEBS LETT, V510, P31, DOI 10.1016/S0014-5793(01)03221-5
Chang KT, 2009, P NATL ACAD SCI USA, V106, P17117, DOI 10.1073/pnas.0904397106
Clayton EL, 2010, NAT NEUROSCI, V13, P845, DOI 10.1038/nn.2571
Collins CA, 2006, NEURON, V51, P57, DOI 10.1016/j.neuron.2006.05.026
Collins CA, 2004, NEURON, V41, P489, DOI 10.1016/S0896-6273(04)00078-9
Cossec JC, 2012, HUM MOL GENET, V21, P3156, DOI 10.1093/hmg/dds142
Cousin MA, 2001, J NEUROCHEM, V76, P105, DOI 10.1046/j.1471-4159.2001.00049.x
Coyle IP, 2004, NEURON, V41, P521, DOI 10.1016/S0896-6273(04)00016-9
Cremona O, 1999, CELL, V99, P179, DOI 10.1016/S0092-8674(00)81649-9
Dickman DK, 2005, CELL, V123, P521, DOI 10.1016/j.cell.2005.09.026
Dickman DK, 2006, CURR BIOL, V16, P591, DOI 10.1016/j.cub.2006.02.058
Dierssen M, 2012, NAT REV NEUROSCI, V13, P844, DOI 10.1038/nrn3314
Di Paolo G, 2004, NATURE, V431, P415, DOI 10.1038/nature02896
Dowjat WK, 2007, NEUROSCI LETT, V413, P77, DOI 10.1016/j.neulet.2006.11.026
Fotaki V, 2002, MOL CELL BIOL, V22, P6636, DOI 10.1128/MCB.22.18.6636-6647.2002
GREENGARD P, 1993, SCIENCE, V259, P780, DOI 10.1126/science.8430330
Guimera J, 1999, GENOMICS, V57, P407, DOI 10.1006/geno.1999.5775
Hammerle B, 2002, DEV BIOL, V246, P259, DOI 10.1006/dbio.2002.067S
Harris TW, 2000, J CELL BIOL, V150, P589, DOI 10.1083/jcb.150.3.589
Himpel S, 2000, J BIOL CHEM, V275, P2431, DOI 10.1074/jbc.275.4.2431
Hong SH, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002857
Huang Y, 2004, BIOCHEMISTRY-US, V43, P10173, DOI 10.1021/bi036060+
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Irie F, 2005, NAT CELL BIOL, V7, P501, DOI 10.1038/ncb1252
Khuong TM, 2010, P NATL ACAD SCI USA, V107, P17379, DOI 10.1073/pnas.1001794107
Koh TW, 2004, NEURON, V43, P193, DOI 10.1016/j.neuron.2004.06.029
Krebs CE, 2013, HUM MUTAT, V34, P1200, DOI 10.1002/humu.22372
Lee S, 2010, J NEUROSCI, V30, P16959, DOI 10.1523/JNEUROSCI.1807-10.2010
Lee SY, 2004, P NATL ACAD SCI USA, V101, P546, DOI 10.1073/pnas.0307813100
LITTLETON JT, 1993, DEVELOPMENT, V118, P1077
Makrantoni V, 2005, YEAST, V22, P401, DOI 10.1002/yea.1220
Mani M, 2007, NEURON, V56, P1004, DOI 10.1016/j.neuron.2007.10.032
Manning G, 2002, SCIENCE, V298, P1912, DOI 10.1126/science.1075762
Marie B, 2004, NEURON, V43, P207, DOI 10.1016/j.neuron.2004.07.001
Matta S, 2012, NEURON, V75, P1008, DOI 10.1016/j.neuron.2012.08.022
Milosevic I, 2011, NEURON, V72, P587, DOI 10.1016/j.neuron.2011.08.029
Murakami N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034845
Ogawa Y, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1090
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Park J, 2009, BMB REP, V42, P6
Pauli A, 2008, DEV CELL, V14, P239, DOI [10.1016/j.devcel.2007.12.009, 10.1016/j.devce1.2007.12.009]
Raucher D, 2000, CELL, V100, P221, DOI 10.1016/S0092-8674(00)81560-3
Ringstad N, 1997, P NATL ACAD SCI USA, V94, P8569, DOI 10.1073/pnas.94.16.8569
Rodal AA, 2008, J NEUROSCI, V28, P8316, DOI 10.1523/JNEUROSCI.2304-08.2008
Roos J, 1998, J BIOL CHEM, V273, P19108, DOI 10.1074/jbc.273.30.19108
Saheki Y, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005645
Schuske KR, 2003, NEURON, V40, P749, DOI 10.1016/S0896-6273(03)00667-6
Schwarz TL, 2006, INT REV NEUROBIOL, V75, P105, DOI 10.1016/S0074-7742(06)75006-1
Sechi AS, 2000, J CELL SCI, V113, P3685
Shupliakov O, 1997, SCIENCE, V276, P259, DOI 10.1126/science.276.5310.259
Slepnev VI, 1998, SCIENCE, V281, P821, DOI 10.1126/science.281.5378.821
Sundborger A, 2011, J CELL SCI, V124, P133, DOI 10.1242/jcs.072686
TEJEDOR F, 1995, NEURON, V14, P287, DOI 10.1016/0896-6273(95)90286-4
Tejedor FJ, 2011, FEBS J, V278, P223, DOI 10.1111/j.1742-4658.2010.07954.x
Verstreken P, 2009, NEURON, V63, P203, DOI 10.1016/j.neuron.2009.06.017
Verstreken P, 2002, CELL, V109, P101, DOI 10.1016/S0092-8674(02)00688-8
Verstreken P, 2003, NEURON, V40, P733, DOI 10.1016/S0896-6273(03)00644-5
Voronov SV, 2008, P NATL ACAD SCI USA, V105, P9415, DOI 10.1073/pnas.0803756105
Wegiel J, 2004, BRAIN RES, V1010, P69, DOI 10.1016/j.brainres.2004.03.008
Yabut O, 2010, J NEUROSCI, V30, P4004, DOI 10.1523/JNEUROSCI.4711-09.2010
Zhang B, 1998, NEURON, V21, P1465, DOI 10.1016/S0896-6273(00)80664-9
Zhou Y, 2011, J PROTEOMICS, V74, P1030, DOI 10.1016/j.jprot.2011.02.007
NR 70
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD JUN
PY 2014
VL 5
AR 4246
DI 10.1038/ncomms5246
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AL0TT
UT WOS:000338840400005
PM 24977345
ER
PT J
AU Grammer, G
Green, V
Amin, R
Alampay, M
AF Grammer, Geoffrey
Green, Vanessa
Amin, Rohul
Alampay, Miguel
TI The Role of rTMS in the Treatment of Psychiatric Disorders Other than
Major Depression
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID TRANSCRANIAL MAGNETIC STIMULATION; OBSESSIVE-COMPULSIVE DISORDER;
POSTTRAUMATIC-STRESS-DISORDER; DOUBLE-BLIND; BIPOLAR DEPRESSION;
CORTICAL EXCITABILITY; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; NEGATIVE
SYMPTOMS; ADD-ON
AB Repetitive transcranial magnetic stimulation (rTMS) offers a noninvasive, safe, and well-tolerated method of neuromodulation. We reviewed existing literature covering rTMS treatment of posttraumatic stress disorder (PTSD), schizophrenia, dementia, bipolar disorder, obsessive-compulsive disorder (OCD), autism spectrum disorder (ASD), and attention-deficit/ hyperactivity disorder (ADHD). Data for PTSD suggest the right dorsolateral prefrontal cortex may be a potential treatment site. rTMS in schizophrenia suggests high-frequency stimulation of the left DLPFC may have some benefit for negative symptoms, and low-frequency stimulation of the primary auditory cortex may assist with auditory hallucinations. The role of rTMS in the diagnosis and treatment of dementia is promising, but further studies are needed. Data for bipolar disorder are inconsistent across the spectrum of mood states. Treatment of OCD by stimulation of the supplementary motor area may have promise. Data are lacking regarding use of rTMS for ASD or ADHD to draw definitive conclusions.
C1 [Grammer, Geoffrey] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Dept Chief Res, Bethesda, MD 20889 USA.
[Green, Vanessa; Amin, Rohul] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Bethesda, MD 20889 USA.
[Alampay, Miguel] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA.
RP Grammer, G (reprint author), Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Dept Chief Res, 4860 South Palmer Rd, Bethesda, MD 20889 USA.
EM Geoffrey.G.Grammer.mil@health.mil
CR Ahmed MA, 2012, J NEUROL, V259, P83, DOI 10.1007/s00415-011-6128-4
Alberici A, 2008, ACTA NEUROL SCAND, V118, P275, DOI 10.1111/j.1600-0404.2008.01017.x
Alonso P, 2001, AM J PSYCHIAT, V158, P1143, DOI 10.1176/appi.ajp.158.7.1143
Anticevic A, 2014, BIOL PSYCHIAT, V75, P595, DOI 10.1016/j.biopsych.2013.10.021
Greenberg BD, 1997, AM J PSYCHIAT, V154, P867
Bentwich J, 2011, J NEURAL TRANSM, V118, P463, DOI 10.1007/s00702-010-0578-1
Berlim MT, 2013, J PSYCHIATR RES, V47, P999, DOI 10.1016/j.jpsychires.2013.03.022
Bloch Y, 2010, WORLD J BIOL PSYCHIA, V11, P755, DOI 10.3109/15622975.2010.484466
Boggio PS, 2011, NEUROPSYCHOL REHABIL, V21, P703, DOI 10.1080/09602011.2011.617943
Boggio PS, 2010, J CLIN PSYCHIAT, V71, P992, DOI 10.4088/JCP.08m04638blu
Cohen H, 2004, AM J PSYCHIAT, V161, P515, DOI 10.1176/appi.ajp.161.3.515
D'Agati E, 2014, J NEURAL TRANSM, V121, P315, DOI 10.1007/s00702-013-1097-7
Dell'Osso B, 2009, BIPOLAR DISORD, V11, P76, DOI 10.1111/j.1399-5618.2008.00651.x
Dlabac-de Lange JJ, 2010, J CLIN PSYCHIAT, V71, P411, DOI 10.4088/JCP.08r04808yel
Enticott PG, 2014, BRAIN STIMUL, V7, P206, DOI 10.1016/j.brs.2013.10.004
Fitzgerald PB, 2006, CLIN NEUROPHYSIOL, V117, P2584, DOI 10.1016/j.clinph.2006.06.712
Freitas C, 2009, SCHIZOPHR RES, V108, P11, DOI 10.1016/j.schres.2008.11.027
Gomes PVO, 2012, J NEUROPSYCH CLIN N, V24, P437, DOI 10.1176/appi.neuropsych.11100242
Harel EV, 2011, WORLD J BIOL PSYCHIA, V12, P119, DOI 10.3109/15622975.2010.510893
Helfrich C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050073
Janicak PG, 2008, J CLIN PSYCHIAT, V69, P222
Karsen EE, 2014, BRAIN STIMUL, V7, P151, DOI 10.1016/j.brs.2013.10.006
Mantovani A, 2010, INT J NEUROPSYCHOPH, V13, P217, DOI 10.1017/S1461145709990435
Matheson SL, 2010, SCHIZOPHR RES, V118, P201, DOI 10.1016/j.schres.2010.01.002
Michael N, 2004, J AFFECT DISORDERS, V78, P253, DOI 10.1016/S0165-0327(02)00308-7
Montagne-Larmurier A, 2011, CURR OPIN PSYCHIATR, V24, P533, DOI 10.1097/YCO.0b013e32834bd26e
Nahas Z, 2003, BIPOLAR DISORD, V5, P40, DOI 10.1034/j.1399-5618.2003.00011.x
Nardone R, 2014, ACTA NEUROL SCAND, V129, P351, DOI 10.1111/ane.12223
Nardone R., 2012, INT J ALZHEIMERS DIS, V2012, DOI DOI 10.1155/2012/687909
Nedjat S, 1999, J ECT, V15, P166
Pallanti S, 2014, J AFFECT DISORDERS, V157, P66, DOI 10.1016/j.jad.2013.12.024
Pennisi G, 2011, J NEURAL TRANSM, V118, P587, DOI 10.1007/s00702-010-0554-9
Praharaj SK, 2009, J AFFECT DISORDERS, V117, P146, DOI 10.1016/j.jad.2008.12.020
Rossi S, 2009, BIOL PSYCHIAT, V66, P54, DOI 10.1016/j.biopsych.2009.03.008
Saba G, 2004, PSYCHIAT RES, V128, P199, DOI 10.1016/j.psychres.2004.05.019
Schneider M, 2007, J NEURAL TRANSM-SUPP, P303
Shah DB, 2008, EXPERT REV MED DEVIC, V5, P559, DOI 10.1586/17434440.5.5.559
Shi C, 2014, PSYCHIAT RES, V215, P505, DOI 10.1016/j.psychres.2013.12.019
Slotema CW, 2012, SCHIZOPHR RES, V142, P40, DOI 10.1016/j.schres.2012.08.025
Vercammen A, 2009, SCHIZOPHR RES, V114, P172, DOI 10.1016/j.schres.2009.07.013
Watts BV, 2012, BRAIN STIMUL, V5, P38, DOI 10.1016/j.brs.2011.02.002
Wozniak-Kwasniewska A, 2013, NEUROIMAGE C, V88C, P91
Xia GH, 2008, INT J NEUROPSYCHOPH, V11, P119, DOI 10.1017/S1461145707007699
NR 43
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
EI 1938-2456
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD JUN
PY 2014
VL 44
IS 6
BP 293
EP 298
DI 10.3928/00485713-20140609-07
PG 6
WC Psychiatry
SC Psychiatry
GA AL0PB
UT WOS:000338827700007
ER
PT J
AU Bavarva, JH
Tae, H
McIver, L
Karunasena, E
Garner, HR
AF Bavarva, Jasmin H.
Tae, Hongseok
McIver, Lauren
Karunasena, Enusha
Garner, Harold R.
TI The Dynamic Exome: acquired variants as individuals age
SO AGING-US
LA English
DT Article
DE Aging; dynamic exome; exome sequencing; personalized genomics;
personalized medicine
ID DE-NOVO MUTATIONS; DNA-SEQUENCING DATA; GENETIC-VARIANTS; GENOME;
AUTISM; EXPRESSION; EVOLUTION; DATABASE; CANCER; DAMAGE
AB A singular genome used for inference into population-based studies is a standard method in genomics. Recent studies show that spontaneous genomic variants can propagate into new generations and these changes can contribute to individual cell aging with environmental and evolutionary elements contributing to cumulative genomic variation. However, the contribution of aging to genomic changes in tissue samples remains uncharacterized. Here, we report the impact of aging on individual human exomes and their implications. We found the human genome to be dynamic, acquiring a varying number of mutations with age (5,000 to 50,000 in 9 to 16 years). This equates to a variation rate of 9.6x10(-7) to 8.4x10(-6) bp(-1) year(-1) for nonsynonymous single nucleotide variants and 2.0x10(-4) to 1.0x10(-3) locus(-1) year(-1) for microsatellite loci in these individuals. These mutations span across 3,000 to 13,000 genes, which commonly showed association with Wnt signaling and Gonadotropin releasing hormone receptor pathways, and indicated for individuals a specific and significant enrichment for increased risk for diabetes, kidney failure, cancer, Rheumatoid arthritis, and Alzheimer's disease- conditions usually associated with aging. The results suggest that "age" is an important variable while analyzing an individual human genome to extract individual-specific clinically significant information necessary for personalized genomics.
C1 [Bavarva, Jasmin H.; Tae, Hongseok; McIver, Lauren; Karunasena, Enusha; Garner, Harold R.] Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA.
RP Bavarva, JH (reprint author), Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA.
EM jasmin.spu@gmail.com; garner@vbi.vt.edu
FU Medical Informatics and Systems Division at Virginia Bioinformatics
Institute; National Science Foundation [OCI-1124123]
FX This work was supported by the Medical Informatics and Systems Division
director's annual fund at Virginia Bioinformatics Institute. The high
performance computing infrastructure on which microsatellite analysis
was conducted was supported by a grant from the National Science
Foundation (OCI-1124123). We thank Heather Lewenczuk for technical help.
The Genomics Research Laboratory (GRL), Virginia Bioinformatics
Institute performed exome sequencing.
CR Altshuler DM, 2012, NATURE, V491, P56, DOI 10.1038/nature11632
Abecasis GR, 2010, NATURE, V467, P1061, DOI DOI 10.1038/NATURE09534
Bavarva JH, 2014, ONCOTARGET
Bavarva JH, 2012, CLIN CHEM, V58, P1720, DOI 10.1373/clinchem.2012.189241
Berger MF, 2012, NATURE, V485, P502, DOI 10.1038/nature11071
Blagosklonny MV, 2011, AGING-US, V3, P1130
Blasco MA, 1997, CELL, V91, P25, DOI 10.1016/S0092-8674(01)80006-4
Boyd-Kirkup JD, 2013, EPIGENOMICS-UK, V5, P205, DOI [10.2217/epi.13.5, 10.2217/EPI.13.5]
Carlsson J, 2004, BRIT J CANCER, V90, P2344, DOI 10.1038/sj.bjc.6601881
Christensen K, 2006, NAT REV GENET, V7, P436, DOI 10.1038/nrg1871
Cooke MS, 2003, FASEB J, V17, P1195, DOI 10.1096/fj.02-0752rev
DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
Diala I, 2013, EMBO REP, V14, P356, DOI 10.1038/embor.2013.16
Dulak AM, 2013, NAT GENET, V45, P478, DOI 10.1038/ng.2591
Ellegren H, 2004, NAT REV GENET, V5, P435, DOI 10.1038/nrg1348
GOUGH AKS, 1994, LANCET, V344, P23, DOI 10.1016/S0140-6736(94)91049-9
Hinrichs AS, 2006, NUCLEIC ACIDS RES, V34, pD590, DOI 10.1093/nar/gkj144
Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
Karolchik D, 2004, NUCLEIC ACIDS RES, V32, pD493, DOI 10.1093/nar/gkh103
Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
Li H, 2010, BIOINFORMATICS, V26, P589, DOI 10.1093/bioinformatics/btp698
Liu XM, 2011, HUM MUTAT, V32, P894, DOI 10.1002/humu.21517
Makrantonaki E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050393
Martin GM, 1996, NAT GENET, V13, P25, DOI 10.1038/ng0596-25
McIver LJ, 2011, GENOMICS, V97, P193, DOI 10.1016/j.ygeno.2011.01.001
McIver LJ, 2013, GENE, V516, P328, DOI 10.1016/j.gene.2012.12.068
McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
de la Chaux N, 2007, BMC EVOL BIOL, V7, DOI 10.1186/1471-2148-7-191
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Ng PC, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000160
Nishizawa M, 2002, J MOL EVOL, V55, P706, DOI 10.1007/s00239-002-2366-5
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Osborne JD, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-S1-S6
Poduri A, 2013, SCIENCE, V341, P43, DOI 10.1126/science.1237758
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sharp NP, 2012, P NATL ACAD SCI USA, V109, P6142, DOI 10.1073/pnas.1118918109
Singh AP, 2004, CANCER RES, V64, P622, DOI 10.1158/0008-5472.CAN-03-2636
Singh AP, 2007, CANCER RES, V67, P433, DOI 10.1158/0008-5472.CAN-06-3114
Stenson PD, 2003, HUM MUTAT, V21, P577, DOI 10.1002/humu.10212
Wang K, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq603
Wang LY, 2010, CNS NEUROL DISORD-DR, V9, P651
Wheeler DA, 2008, NATURE, V452, P872, DOI 10.1038/nature06884
Wirgin I, 2011, SCIENCE, V331, P1322, DOI 10.1126/science.1197296
Zhang F, 2007, MECH AGEING DEV, V128, P415, DOI 10.1016/j.mad.2007.05.007
Zong CH, 2012, SCIENCE, V338, P1622, DOI 10.1126/science.1229164
NR 45
TC 2
Z9 2
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUN
PY 2014
VL 6
IS 6
BP 511
EP 521
PG 11
WC Cell Biology
SC Cell Biology
GA AL3TX
UT WOS:000339053400009
PM 25063753
ER
PT J
AU Hadley, D
Wu, ZL
Kao, C
Kini, A
Mohamed-Hadley, A
Thomas, K
Vazquez, L
Qiu, HJ
Mentch, F
Pellegrino, R
Kim, C
Connolly, J
Glessner, J
Hakonarson, H
AF Hadley, Dexter
Wu, Zhi-liang
Kao, Charlly
Kini, Akshata
Mohamed-Hadley, Alisha
Thomas, Kelly
Vazquez, Lyam
Qiu, Haijun
Mentch, Frank
Pellegrino, Renata
Kim, Cecilia
Connolly, John
Glessner, Joseph
Hakonarson, Hakon
CA AGP Consortium
TI The impact of the metabotropic glutamate receptor and other gene family
interaction networks on autism
SO NATURE COMMUNICATIONS
LA English
DT Article
ID COPY NUMBER VARIATION; DE-NOVO MUTATIONS; SPECTRUM DISORDERS; POSITIVE
ASSOCIATIONS; SUBUNIT GENES; GENOME; SCHIZOPHRENIA; VARIANTS;
POLYMORPHISMS; PROTEIN
AB Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P <= 2.40E - 09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P <= 3.83E - 23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P <= 4.16E - 04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions.
C1 [Hadley, Dexter; Wu, Zhi-liang; Kao, Charlly; Kini, Akshata; Mohamed-Hadley, Alisha; Thomas, Kelly; Vazquez, Lyam; Qiu, Haijun; Mentch, Frank; Pellegrino, Renata; Kim, Cecilia; Connolly, John; Glessner, Joseph; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
[Hakonarson, Hakon] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
RP Hakonarson, H (reprint author), Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
EM hakonarson@email.chop.edu
RI Duque, Frederico/H-3692-2014; Bailey, Anthony/J-2860-2014; Jacob,
Suma/J-7941-2013; Scherer, Stephen /B-3785-2013; Bolton,
Patrick/E-8501-2010
OI Duque, Frederico/0000-0001-5684-1472; Bailey,
Anthony/0000-0003-4257-972X; Jacob, Suma/0000-0001-7434-7398; Scherer,
Stephen /0000-0002-8326-1999; Bolton, Patrick/0000-0002-5270-6262
FU Institutional Development Fund from The Children's Hospital of
Philadelphia; Margaret Q Landenberger Foundation; Lurie Family
Foundation; Kubert Estate Fund [U01HG005830]; National Institute of
Mental Health [1U24MH081810]; [MH64547]
FX We thank all study participants and their families. We thank all the
staff at the Center for Applied Genomics at CHOP for their invaluable
contributions to recruitment of study subjects and genotyping of
samples. We also gratefully acknowledge the resources provided by the
AGRE Consortium and their participating families, and by the Autism
Genome Project (AGP) Consortium and their participating families. The
study was funded by an Institutional Development Fund from The
Children's Hospital of Philadelphia; The Margaret Q Landenberger
Foundation; The Lurie Family Foundation; The Kubert Estate Fund and by
U01HG005830. AGRE is a program of Autism Speaks and is at present
supported, in part, by grant 1U24MH081810 from the National Institute of
Mental Health to C.M. Lajonchere (PI) and formerly by grant MH64547 to
D.H. Geschwind (PI). AGRE-approved academic researchers can acquire the
data sets from AGRE at http://www.agre.org. There were 1,693 cases of
the full AGP data sets that were genotyped by the AGP consortium. The
full AGP data sets are made available from dbGaP at
http://www.ncbi.nlm.nih.gov/gap. The remaining 5,049 cases and all
12,544 controls were all genotyped by the Center for Applied Genomics at
the Children's Hospital of Philadelphia.
CR Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
Autism and Developmental Disabilities Monitoring Network Surveillance Year, 2007, MMWR SURVEILL SUMM, V56, P12
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators, 2009, MMWR SURVEILL SUMM, V58, P1
BAILEY A, 1995, PSYCHOL MED, V25, P63
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Blumberg SJ, 2013, CHANGES PREVALENCE P, P20782
Bolonna AA, 2001, SCHIZOPHR RES, V47, P99, DOI 10.1016/S0920-9964(99)00235-2
Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
Cann HM, 2002, SCIENCE, V296, P261
Collins AL, 2006, NEUROGENETICS, V7, P167, DOI 10.1007/s10048-006-0045-1
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Cusco I, 2009, HUM MOL GENET, V18, P1795, DOI 10.1093/hmg/ddp092
Elia J, 2012, NAT GENET, V44, P78, DOI 10.1038/ng.1013
Elia J., 2009, MOL PSYCHIATR, V15, P637
Elliott E, 2009, J NEUROCHEM, V109, P1168, DOI 10.1111/j.1471-4159.2009.06047.x
Elliott E, 2007, J BIOL CHEM, V282, P37276, DOI 10.1074/jbc.M706379200
FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
Fujii Y, 2003, PSYCHIAT GENET, V13, P71, DOI 10.1097/01.ypg.0000056682.82896.b0
Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
Glessner JT, 2010, P NATL ACAD SCI USA, V107, P10584, DOI 10.1073/pnas.1000274107
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Hadley D, 2006, GENOME BIOL, V7, DOI 10.1186/gb-2006-7-11-r105
Hermanson O, 2002, NATURE, V419, P934, DOI 10.1038/nature01156
Hopkins AL, 2002, NAT REV DRUG DISCOV, V1, P727, DOI 10.1038/nrd892
Huguet G, 2013, ANNU REV GENOM HUM G, V14, P191, DOI 10.1146/annurev-genom-091212-153431
Altshuler DM, 2010, NATURE, V467, P52, DOI 10.1038/nature09298
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kao HT, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009372
Kikuno R, 2004, NUCLEIC ACIDS RES, V32, pD502, DOI 10.1093/nar/gkh035
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Kolevzon A, 2004, AM J MED GENET B, V129B, P76, DOI 10.1002/ajmg.b.30011
Li H, 2008, AM J MED GENET B, V147B, P194, DOI 10.1002/ajmg.b.30584
Li Z.-J., 2008, FA YI XUE ZA ZHI, V24, P377
Li Zhong-Jie, 2008, Fa Yi Xue Za Zhi, V24, P369
Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
Matsunami N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0052239
McMahon FJ, 2012, NEURON, V74, P773, DOI 10.1016/j.neuron.2012.05.004
Moreno-De-Luca D, 2013, MOL PSYCHIATR, V18, P1090, DOI 10.1038/mp.2012.138
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Nair SK, 2003, CELL, V112, P193, DOI 10.1016/S0092-8674(02)01284-9
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Noh HJ, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003523
Ohtsuki T, 2008, SCHIZOPHR RES, V101, P9, DOI 10.1016/j.schres.2008.01.027
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
R Core Team, 2013, R LANG ENV STAT COMP
Rual JF, 2005, NATURE, V437, P1173, DOI 10.1038/nature04209
Sakai Y, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002166
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Serajee FJ, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.4.e42
Shibata H, 2009, PSYCHIAT RES, V167, P88, DOI 10.1016/j.psychres.2007.12.002
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Takaki H, 2004, AM J MED GENET B, V128B, P6, DOI 10.1002/ajmg.b.20108
van der Zwaag B, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005324
Venkatesan K, 2009, NAT METHODS, V6, P83, DOI [10.1038/nmeth.1280, 10.1038/NMETH.1280]
Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 66
TC 5
Z9 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD JUN
PY 2014
VL 5
AR 4074
DI 10.1038/ncomms5074
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AL0SV
UT WOS:000338838000018
PM 24927284
ER
PT J
AU Evans, B
AF Evans, Bonnie
TI The Foundations of Autism: The Law Concerning Psychotic, Schizophrenic,
and Autistic Children in 1950s and 1960s Britain
SO BULLETIN OF THE HISTORY OF MEDICINE
LA English
DT Article
DE autism; psychosis; social science; Maudsley Hospital; Britain; mental
deficiency; children; Mental Health Act 1959; institutional care
ID ADOLESCENT-PSYCHIATRY; PREVALENCE; DISORDER
AB While the origins of child psychiatry in Britain can be traced to the interwar period, contemporary concepts and methodological approaches to pathological mental development in children were not created until the 1950s and 1960s. It was at this time that one of the most salient and lasting diagnoses in child psychiatry, autism, was established through a network of intellectual, institutional, and legal changes in Britain. This article argues that the work of child psychiatrists at the Maudsley Hospital was central in driving these changes and uses archival sources from this hospital, along with other legal and intellectual sources, to explore attempts to conceptualize pathological thought in infants in the 1950s and 1960s. When the first epidemiological study of autism was published in 1966, this finally established the autistic child as a scientific, demographic, and social reality in Britain.
C1 Univ London, London WC1E 7HU, England.
RP Evans, B (reprint author), Univ London, London WC1E 7HU, England.
EM b.evans@qmul.ac.uk
FU Wellcome Trust [077889, 086071]
FX The author wishes to thank Professor John Forrester and Edgar Jones.
Many thanks also go to Professor Sir Michael Rutter, Professor Patrick
Bolton, and all the staff at the MRC Social, Genetic and Developmental
Psychiatry Centre for their assistance with the project. Thanks are also
due to the staff of the U.K. National Archives. Finally, the author
wishes to thank the Wellcome Trust for supporting this research under
grant numbers 077889 and 086071.
CR Allderidge Patricia, 1991, 150 YEARS BRIT PSYCH, P79
Allison Helen, 1988, COMMUNICATION, V22, P6
[Anonymous], COMMUNICATION
[Anonymous], COMMUNICATION
[Anonymous], 1962, COMMUNICATION
[Anonymous], COMMUNICATION
[Anonymous], 2006, COMMUNICATION
[Anonymous], 1982, COMMUNICATION
[Anonymous], 1963, LANCET, V281, P782
[Anonymous], COMMUNICATION
[Anonymous], 1978, COMMUNICATION
[Anonymous], 1964, COMMUNICATION
[Anonymous], COMMUNICATION
[Anonymous], 1961, COMMUNICATION
[Anonymous], COMMUNICATION
Anthony Elwyn James, 1957, CAS C, V4
Anthony Elwyn James, 1958, CAS C, V5
Anthony Elwyn James, 1958, ACTA PAEDOPSYCHIATR, V25, P90
ANTHONY EJ, 1956, BRIT J MED PSYCHOL, V29, P20
Anthony Elwyn James, 1958, BRIT J MED PSYCHOL, V31, P211
Anthony Elwyn James, 1957, CLIN ASPECTS CHILDHO
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Beer MD, 1995, HIST PSYCHIATR, V6, P177, DOI 10.1177/0957154X9500602204
BENDER L, 1947, AM J ORTHOPSYCHIAT, V17, P40
Bender L., 1947, AM J ORTHOPSYCHIAT, V17, P53
Berrios GE, 1996, HIST MENTAL SYMPTOMS
BERRIOS GE, 1987, BRIT MED BULL, V43, P484
Bleuler E, 1911, DEMENTIA PRAECOX GRO
Cameron K, 1955, BRIT J MED PSYCHOL, V28, P67
Cameron Kenneth, 1955, MED PRESS, P280
Cameron Kenneth, 1958, ACTA PAEDOPSYCHIATRI, V25
Chapman Michael, 1988, CONSTRUCTIVE EVOLUTI, P121
Creak Mildred, 1940, AM J PSYCHIAT, V97, P395
Creak Mildred, 1961, BRIT MED J, V2, P889
Creak M, 1938, Proc R Soc Med, V31, P519
Creak Mildred, 1938, P ROY SOC MED, V31, P528
Ellenberger Henri F., 1970, DISCOV UNCONSCIOUS, p[287, 406]
Ellis Havelock, 1899, STUDIES PSYCHOL SEX, V1, P130
Evans B, 2008, HIST PSYCHIATR, V19, P454, DOI 10.1177/0957154X08089619
Eyal G., 2010, AUTISM MATRIX
Feinstein Adam, 2010, HIST AUTISM CONVERSA
Ford Julienne, 1982, SPECIAL ED SOCIAL CO, P24
Freud Sigmund, 2001, STANDARD EDITION, V3, P58
Great Britain Government Document: Committee on Local Authority and Allied Personal Services, 1968, REP COMM LOC AUTH AL, P25
Great Britain Government Document: Department of Education and Science, 1978, SPEC ED NEEDS, P1
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Harris Bernard, 1995, HLTH SCHOOLCHILD
Hendrick Harry, 1994, CHILD WELFARE ENGLAN, P11
Hendrick Harry, 1994, CHILD WELFARE, P196
Hermelin B., 1963, BRIT J SOC CLIN PSYC, V2, P37, DOI 10.1111/j.2044-8260.1963.tb00373.x
HERSOV L, 1986, J CHILD PSYCHOL PSYC, V27, P781, DOI 10.1111/j.1469-7610.1986.tb00201.x
Hilliard Leslie, 1957, MENTAL DEFICIENCY, P8
Jones Edgar, 2007, MED HIST, V51
Jones Edgar, 2007, MED HIST, V51
Jones Kathleen, 1972, HIST MENTAL HLTH SER, P306
Kanner L, 1943, NERV CHILD, V2, P217
Kanner Leo, 1943, NERV CHILD, V2, P248
Klein M, 1930, INT J PSYCHOANAL, V11, P24
Klein Melanie, 1929, INT J PSYCHOANAL, V10, p[193, 195]
Levene A., 2006, HIST FAMILY, V11, P67, DOI 10.1016/j.hisfam.2006.06.001
Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048
Meyers DI, 1997, INT J PSYCHOANAL, V78, P391
Moskowitz A., 2005, JANETIAN STUD
Murray Stuart, 2008, REPRESENTING AUTISM, P175
Nadesan Majia Holmer, 2005, CONSTRUCTING AUTISM
OCONNOR N, 1951, J NEUROL NEUROSUR PS, V14, P226, DOI 10.1136/jnnp.14.3.226
O'Connor Neil, 1956, SOCIAL PROBLEM MENTA
Phtiaka Helen, 1997, SPECIAL KIDS SPECIAL, P9
Piaget J., 1923, LANGUAGE THOUGHT CHI
Rose N. S., 1999, GOVERNING SOUL, P176
Rose Nikolas, 1999, GOVERNING SOUL, P170
RUTTER M, 1975, BRIT J PSYCHIAT, V126, P493, DOI 10.1192/bjp.126.6.493
Rutter Michael, 2001, PSYCHOL BRITAIN, P422
Shepherd Michael, 1990, CONCEPTUAL ISSUES PS, P134
Shorter Edward, 1997, HIST PSYCHIATR, P107
Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
Stewart John, 2004, PUBLIC HLTH PREVENTI, P85
Sutherland Gillian, 1984, ABILITY MERIT MEASUR, P55
Thom Deborah, 1992, NAME CHILD HLTH WELF, P200
Thomson Mathew, 1998, PROBLEM MENTAL DEFIC, P33
TIZARD J, 1965, P ROY SOC MED, V58, P373
Tizard Jack, 1983, CHILD DEV SOCIAL POL, P37
WARDLE CJ, 1991, BRIT J PSYCHIAT, V159, P53, DOI 10.1192/bjp.159.1.53
WARREN W, 1971, J CHILD PSYCHOL PSYC, V11, P241
Watkin Brian, 1975, DOCUMENTS HLTH SOCIA, P387
Wing J. K., 1966, EARLY CHILDHOOD AUTI
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
NR 87
TC 0
Z9 0
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 0007-5140
EI 1086-3176
J9 B HIST MED
JI Bull. Hist. Med.
PD SUM
PY 2014
VL 88
IS 2
BP 253
EP 286
PG 34
WC Health Care Sciences & Services; History & Philosophy Of Science
SC Health Care Sciences & Services; History & Philosophy of Science
GA AK1IQ
UT WOS:000338169200002
PM 24976162
ER
PT J
AU Pacheva, I
Panov, G
Gillberg, C
Neville, B
AF Pacheva, Iliyana
Panov, Georgi
Gillberg, Christopher
Neville, Brian
TI A Girl with Tuberous Sclerosis Complex Presenting with Severe Epilepsy
and Electrical Status Epilepticus During Sleep, and with
High-Functioning Autism and Mutism
SO COGNITIVE AND BEHAVIORAL NEUROLOGY
LA English
DT Article
DE tuberous sclerosis complex; high-functioning autism; hyperlexia; mutism;
electrical status epilepticus
ID SPECTRUM DISORDERS; CHILDREN; APRAXIA; SPEECH; SEIZURES; TARGET
AB Most patients with tuberous sclerosis complex (TSC) suffer from epilepsy, and many have cognitive and behavioral problems like severe intellectual disability, autism, and hyperactivity. Only rare patients with TSC and autism have a normal intelligence quotient. We report a 13-year-old girl with definite TSC who had early-onset severe epilepsy, autistic behavior, and moderate developmental delay. By school age, however, she had normal intelligence; her intelligence quotient was at least 70 based on a Stanford-Binet test that she refused to complete. She showed good reading, writing, and language comprehension skills, and the special abilities of hyperlexia, hypermnesia, and hypercalculia. However, she did not speak. Criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and her Childhood Autism Rating Scale score of 36 indicated mild to moderate autism. She had severe electroencephalographic abnormalities: hypsarrhythmia, multifocal or generalized epileptiform discharges, and electrical status epilepticus during sleep, with a continuous left temporal focus. Magnetic resonance imaging showed many cortical tubers in all brain lobes, and subependymal nodules. We discuss possible explanations for her lack of speech. Considered as speech apraxia, her mutism could be either a symptom of her TSC or a component of her autism. Another possibility is that long-lasting electrical status epilepticus during sleep led to her autistic behavior and language arrest. Still another possibility is that a disinhibited mammalian target of rapamycin (mTOR) pathway was at the root of all of her neuropsychiatric symptoms.
C1 [Pacheva, Iliyana] Med Univ, Dept Pediat & Med Genet, Plovdiv, Bulgaria.
[Panov, Georgi] Hosp Stoyan Kirkovich, Neurol & Neurophysiol Unit, Stara Zagora, Bulgaria.
[Gillberg, Christopher] Gothenburg Univ, Dept Child & Adolescent Psychiat, Gothenburg, Sweden.
[Gillberg, Christopher; Neville, Brian] UCL, Inst Child Hlth, Neurosci Unit, London, England.
[Gillberg, Christopher; Neville, Brian] Young Epilepsy, Lingfield, Surrey, England.
RP Pacheva, I (reprint author), 10 Rozhen Str, Plovdiv 4000, Bulgaria.
EM inapatcheva@hotmail.com
CR Alpern G, 1986, DEV PROFILE
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bolton PF, 1997, LANCET, V349, P392, DOI 10.1016/S0140-6736(97)80012-8
Bonilha L, 2006, NEUROREPORT, V17, P1027, DOI 10.1097/01.wnr.0000223388.28834.50
Curatolo Paolo, 2002, Eur J Paediatr Neurol, V6, P15, DOI 10.1053/ejpn.2001.0538
Curatolo P, 2004, EUR J PAEDIATR NEURO, V8, P327, DOI 10.1016/j.ejpn.2004.08.005
Ehninger D, 2011, TRENDS MOL MED, V17, P78, DOI 10.1016/j.molmed.2010.10.002
GAGGERO R, 1995, CHILD NERV SYST, V11, P154, DOI 10.1007/BF00570256
Galanopoulou AS, 2012, EPILEPSIA, V53, P1119, DOI 10.1111/j.1528-1167.2012.03506.x
GANJI S, 1985, CLIN ELECTROENCEPHAL, V16, P219
GILLBERG IC, 1994, DEV MED CHILD NEUROL, V36, P50
Grigorenko EL, 2002, J AUTISM DEV DISORD, V32, P3, DOI 10.1023/A:1017995805511
Guerrini R, 1998, NEUROLOGY, V51, P504
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Jozwiak S, 2011, EUR J PAEDIATR NEURO, V15, P424, DOI 10.1016/j.ejpn.2011.03.010
Kjellmer L, 2012, RES DEV DISABIL, V33, P172, DOI 10.1016/j.ridd.2011.09.003
Krueger DA, 2010, NEW ENGL J MED, V363, P1801, DOI 10.1056/NEJMoa1001671
Napolioni V, 2009, BRAIN DEV-JPN, V31, P104, DOI 10.1016/j.braindev.2008.09.013
Ogar J, 2005, NEUROCASE, V11, P427, DOI 10.1080/13554790500263529
Panayiotopoulos C., 2005, EPILEPSIES SEIZURES, P137
Peltola ME, 2011, EPILEPSIA, V52, P602, DOI 10.1111/j.1528-1167.2010.02783.x
Roach ES, 1998, J CHILD NEUROL, V13, P624
Samir H, 2011, EUR J PAEDIATR NEURO, V15, P131, DOI 10.1016/j.ejpn.2010.07.010
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shriberg LD, 2011, J AUTISM DEV DISORD, V41, P405, DOI 10.1007/s10803-010-1117-5
Wong M, 2010, EPILEPSIA, V51, P27, DOI 10.1111/j.1528-1167.2009.02341.x
Zhang B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057445
NR 27
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1543-3633
EI 1543-3641
J9 COGN BEHAV NEUROL
JI Cogn. Behav. Neurol.
PD JUN
PY 2014
VL 27
IS 2
BP 88
EP 95
PG 8
WC Behavioral Sciences; Clinical Neurology
SC Behavioral Sciences; Neurosciences & Neurology
GA AK0VS
UT WOS:000338134800004
PM 24968009
ER
PT J
AU Gadow, KD
Smith, RM
Pinsonneault, JK
AF Gadow, Kenneth D.
Smith, Ryan M.
Pinsonneault, Julia K.
TI Serotonin 2A Receptor Gene (HTR2A) Regulatory Variants: Possible
Association with Severity of Depression Symptoms in Children with Autism
Spectrum Disorder
SO COGNITIVE AND BEHAVIORAL NEUROLOGY
LA English
DT Article
DE autism spectrum disorder; depression; HTR2A; rs6311; rs6314
ID POSITRON-EMISSION-TOMOGRAPHY; COMORBID PSYCHIATRIC-DISORDERS; SEASONAL
AFFECTIVE-DISORDER; FAMILY-BASED ASSOCIATION; 5-HT2A RECEPTOR; MAJOR
DEPRESSION; PLATELET SEROTONIN; SCORING ALGORITHMS; CLINICAL UTILITY;
MESSENGER-RNA
AB Objective and Background: Our aim was to characterize the association of 2 functional single nucleotide polymorphisms (rs6311 and rs6314) in the serotonin 2A receptor gene (HTR2A) with severity of depression symptoms in children with autism spectrum disorder. These polymorphisms have been shown to be associated with depression symptom severity and response to selective serotonin reuptake inhibitor drugs in adults with diagnosed depressive disorder.
Methods: Parents of 104 children with autism spectrum disorder rated their children's depressive symptoms using a validated scale based on criteria from the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. We compared severity of depression symptoms across the rs6311 and rs6314 genotypes, measured from the children's genomic DNA.
Results: Children homozygous for the G allele of rs6311 had significantly more severe depression symptoms than those with G/A or A/A genotypes (P=0.025). The effect size (partial eta-squared) was small (eta p(2)=0.047) but was somewhat larger when we controlled for severity of generalized anxiety disorder symptoms (P=0.006, eta p(2)=0.072). When we restricted our analyses to white participants, our results were essentially the same as for the entire sample (P=0.004, eta p(2)=0.086). There was no significant association between rs6314 (C/C versus T carriers) and severity of depression.
Conclusions: Our findings suggest that the HTR2A functional rs6311 polymorphism, which other studies have associated with differential HTR2A mRNA expression, may modulate the severity of depression symptoms in children with autism spectrum disorder. These tentative, hypothesis-generating findings need replication with larger, independent samples.
C1 [Gadow, Kenneth D.] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA.
[Smith, Ryan M.; Pinsonneault, Julia K.] Ohio State Univ, Dept Pharmacol, Wexner Med Ctr, Ctr Pharmacogen, Columbus, OH 43210 USA.
RP Gadow, KD (reprint author), SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA.
EM kenneth.gadow@stonybrook.edu
FU Matt and Debra Cody Center for Autism and Developmental Disorders;
National Institute of General Medical Sciences [U01 GM092655]
FX Supported in part by the Matt and Debra Cody Center for Autism and
Developmental Disorders, by charitable contributions, and by National
Institute of General Medical Sciences Grant U01 GM092655. Wolfgang
Sadee, PhD, Principal Investigator.
CR Alvarez JC, 1999, CLIN PHARMACOL THER, V66, P617
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
Arias B, 2001, MOL PSYCHIATR, V6, P239, DOI 10.1038/sj.mp.4000818
Attar-Levy D, 1999, BIOL PSYCHIAT, V45, P180, DOI 10.1016/S0006-3223(98)00007-9
Baganz NL, 2013, ACS CHEM NEUROSCI, V4, P48, DOI 10.1021/cn300186b
Bakken TL, 2010, RES DEV DISABIL, V31, P1669, DOI 10.1016/j.ridd.2010.04.009
Belsky J, 2009, PSYCHOL BULL, V135, P885, DOI 10.1037/a0017376
Belsky J, 2009, MOL PSYCHIATR, V14, P746, DOI 10.1038/mp.2009.44
Biver F, 1997, BRIT J PSYCHIAT, V171, P444, DOI 10.1192/bjp.171.5.444
Bull SJ, 2009, MOL PSYCHIATR, V14, P1095, DOI 10.1038/mp.2008.48
Cadman T, 2012, J AM ACAD CHILD PSY, V51, P879, DOI 10.1016/j.jaac.2012.06.017
Cho IH, 2007, BRAIN RES, V1139, P34, DOI 10.1016/j.brainres.2007.01.002
Choi MJ, 2004, NEUROPSYCHOBIOLOGY, V49, P38, DOI 10.1159/000075337
Christiansen L, 2007, BIOL PSYCHIAT, V61, P223, DOI 10.1016/j.biopsych.2006.03.046
Ciarleglio CM, 2011, NEUROSCIENCE, V197, P8, DOI 10.1016/j.neuroscience.2011.09.036
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
COOK EH, 1993, LIFE SCI, V52, P2005, DOI 10.1016/0024-3205(93)90685-V
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Daniels JL, 2008, PEDIATRICS, V121, pE1357, DOI 10.1542/peds.2007-2296
Davies MA, 2006, PHARMACOGENOMICS J, V6, P42, DOI 10.1038/sj.tpj.6500342
Depino AM, 2013, MOL CELL NEUROSCI, V53, P69, DOI 10.1016/j.mcn.2012.10.003
DeVincent CJ, 2009, AUTISM RES, V2, P312, DOI 10.1002/aur.106
Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
Dwivedi Y, 2005, NEUROPHARMACOLOGY, V48, P204, DOI 10.1016/j.neuropharm.2004.10.004
ECKERT A, 1993, BIOL PSYCHIAT, V34, P565, DOI 10.1016/0006-3223(93)90201-N
Fiocco AJ, 2007, FRONT BEHAV NEUROSCI, V1, DOI [10.3389/neuro.08.003.2007, 10.3389/neuro.08/003.2007]
Franke L, 2000, LIFE SCI, V67, P301, DOI 10.1016/S0024-3205(00)00620-2
Frisch A, 1999, MOL PSYCHIATR, V4, P389, DOI 10.1038/sj.mp.4000536
Gadow K. D., 2002, CHILD SYMPTOM INVENT
Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gadow KD, 2012, J AUTISM DEV DISORD, V42, P1353, DOI 10.1007/s10803-011-1367-x
Gadow KD, 2011, SYMPTOM INVENTORIES
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P419, DOI 10.1007/s10803-007-0408-y
Gadow KD, 2013, PROG NEURO-PSYCHOPH, V40, P292, DOI 10.1016/j.pnpbp.2012.10.019
Girgis RR, 2011, PSYCHIAT RES-NEUROIM, V194, P230, DOI 10.1016/j.pscychresns.2011.04.007
Goines PE, 2013, NEUROTOXICOL TERATOL, V36, P67, DOI 10.1016/j.ntt.2012.07.006
Goldberg J, 2009, J AUTISM DEV DISORD, V39, P97, DOI 10.1007/s10803-008-0604-4
Guhathakurta S, 2009, NEUROCHEM INT, V55, P754, DOI 10.1016/j.neuint.2009.07.008
Hazelwood LA, 2004, MOL PHARMACOL, V66, P1293
Hernandez I, 2000, J NEUROSCI RES, V59, P218, DOI 10.1002/(SICI)1097-4547(20000115)59:2<218::AID-JNR8>3.0.CO;2-H
Hollingshead AB, 4 FACTOR INDEX SOCIA
Hranilovic D, 2009, J NEURAL TRANSM, V116, P493, DOI 10.1007/s00702-009-0192-2
Hranilovic D, 2010, PSYCHIAT RES, V178, P556, DOI 10.1016/j.psychres.2010.04.007
Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
Jin CH, 2013, NEUROL RES, V35, P7, DOI 10.1179/1743132812Y.0000000111
Johansson C, 2001, NEUROBIOL DIS, V8, P351, DOI 10.1006/nbdi.2000.0373
Kaat AJ, 2013, J ABNORM CHILD PSYCH, V41, P959, DOI 10.1007/s10802-013-9739-7
Kamata M, 2011, J AFFECT DISORDERS, V135, P374, DOI 10.1016/j.jad.2011.08.027
Kato M, 2010, MOL PSYCHIATR, V15, P473, DOI 10.1038/mp.2008.116
Kim JM, 2012, J AFFECT DISORDERS, V136, P833, DOI 10.1016/j.jad.2011.09.029
Kistner-Griffin E, 2011, AM J MED GENET B, V156B, P139, DOI 10.1002/ajmg.b.31146
Kronfeld-Schor N, 2012, NEUROPHARMACOLOGY, V62, P101, DOI 10.1016/j.neuropharm.2011.08.020
KUSUMI I, 1994, PSYCHOPHARMACOLOGY, V113, P322, DOI 10.1007/BF02245204
Lapin JP, 1969, LANCET, V1, P132
Lecavalier L, 2009, J AUTISM DEV DISORD, V39, P278, DOI 10.1007/s10803-008-0622-2
Lee HJ, 2006, J AFFECT DISORDERS, V95, P145, DOI 10.1016/j.jad.2006.05.001
Lee LC, 2008, PAEDIATR PERINAT EP, V22, P172, DOI 10.1111/j.1365-3016.2007.00919.x
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lopez-Munoz F, 2009, CURR PHARM DESIGN, V15, P1563
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
Magnuson KM, 2011, J DEV BEHAV PEDIATR, V32, P332, DOI 10.1097/DBP.0b013e318213f56c
Maier SF, 2003, BRAIN BEHAV IMMUN, V17, P69, DOI 10.1016/S0889-1591(03)00032-1
MCBRIDE PA, 1989, ARCH GEN PSYCHIAT, V46, P213
Meltzer CC, 1999, AM J PSYCHIAT, V156, P1871
Meyer JH, 2001, AM J PSYCHIAT, V158, P78, DOI 10.1176/appi.ajp.158.1.78
Miller AH, 2013, DEPRESS ANXIETY, V30, P297, DOI 10.1002/da.22084
Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
Minov C, 2001, NEUROSCI LETT, V303, P119, DOI 10.1016/S0304-3940(01)01704-9
Molnar E, 2010, EUR NEUROPSYCHOPHARM, V20, P655, DOI 10.1016/j.euroneuro.2010.04.009
MuckSeler D, 1996, J AFFECT DISORDERS, V39, P73, DOI 10.1016/0165-0327(96)00024-9
Muck-Seler D, 2004, PSYCHIAT RES, V127, P217, DOI 10.1016/j.psychres.2004.04.001
Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934
Narasimhan S, 2012, PHARMACOGENOMICS, V13, P441, DOI [10.2217/pgs.12.1, 10.2217/PGS.12.1]
National Center for Biotechnology Information, INT HAPM PROJ
Oreland S, 2009, BRAIN RES, V1305, pS37, DOI 10.1016/j.brainres.2009.08.069
Oswald P, 2003, EUR NEUROPSYCHOPHARM, V13, P365, DOI 10.1016/S0924-977X(03)00041-5
Pivac N, 2003, PROG NEURO-PSYCHOPH, V27, P759, DOI 10.1016/S0278-5846(03)00105-2
Pjrek E, 2004, J CLIN PSYCHIAT, V65, P1389
Pouw LBC, 2013, RES AUTISM SPECT DIS, V7, P549, DOI 10.1016/j.rasd.2013.01.002
Raison CL, 2013, MOL PSYCHIATR, V18, P15, DOI 10.1038/mp.2012.2
Roohi J, 2009, J AUTISM DEV DISORD, V39, P67, DOI 10.1007/s10803-008-0600-8
Ruljancic N, 2013, MAGNESIUM RES, V26, P9, DOI 10.1684/mrh.2013.0332
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Savitz JB, 2013, NEUROBIOL DIS, V52, P49, DOI 10.1016/j.nbd.2012.06.001
SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
Sheline YI, 2004, NEUROPSYCHOPHARMACOL, V29, P2235, DOI 10.1038/sj.npp.1300555
Shimbo D, 2002, AM J CARDIOL, V89, P331, DOI 10.1016/S0002-9149(01)02236-6
Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Slavich GM, 2010, P NATL ACAD SCI USA, V107, P14817, DOI 10.1073/pnas.1009164107
Smith RM, 2014, AUTISM RES, V7, P459, DOI 10.1002/aur.1383
Smith RM, 2013, BIOL PSYCHIAT, V73, P546, DOI 10.1016/j.biopsych.2012.09.028
Spurlock G, 1998, MOL PSYCHIATR, V3, P42, DOI 10.1038/sj.mp.4000342
Thanseem I, 2012, BIOL PSYCHIAT, V71, P410, DOI 10.1016/j.biopsych.2011.09.020
Uebelback R, 2006, NEUROSCI LETT, V406, P153, DOI 10.1016/j.neulet.2006.06.004
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Veenstra-VanderWeele J, 2002, AM J MED GENET, V114, P277, DOI 10.1002/ajmg.10192
Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3
Wilkie MJV, 2009, PHARMACOGENOMICS J, V9, P61, DOI 10.1038/sj.tpj.6500491
Willeit M, 2010, NEUROIMAGE, V53, P878, DOI 10.1016/j.neuroimage.2010.04.030
Willins DL, 1998, ANN NY ACAD SCI, V861, P121, DOI 10.1111/j.1749-6632.1998.tb10182.x
Witwer AN, 2010, J DEV PHYS DISABIL, V22, P367, DOI 10.1007/s10882-010-9194-0
Yatham LN, 2000, ARCH GEN PSYCHIAT, V57, P850, DOI 10.1001/archpsyc.57.9.850
NR 106
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1543-3633
EI 1543-3641
J9 COGN BEHAV NEUROL
JI Cogn. Behav. Neurol.
PD JUN
PY 2014
VL 27
IS 2
BP 107
EP 116
PG 10
WC Behavioral Sciences; Clinical Neurology
SC Behavioral Sciences; Neurosciences & Neurology
GA AK0VS
UT WOS:000338134800007
PM 24968012
ER
PT J
AU Luxton, GWG
Starr, DA
AF Luxton, G. W. Gant
Starr, Daniel A.
TI KASHing up with the nucleus: novel functional roles of KASH proteins at
the cytoplasmic surface of the nucleus
SO CURRENT OPINION IN CELL BIOLOGY
LA English
DT Article
ID PERINUCLEAR ACTIN CAP; SUN PROTEINS; LINC COMPLEXES; ENVELOPE;
MIGRATION; MECHANOTRANSDUCTION; MOVEMENT; CYTOSKELETON; CONNECTIONS;
CENTROSOME
AB Nuclear-cytoskeletal connections are central to fundamental cellular processes, including nuclear positioning and chromosome movements in meiosis. The cytoskeleton is coupled to the nucleoskeleton through conserved KASH-SUN bridges, or LING complexes, that span the nuclear envelope. KASH proteins localize to the outer nuclear membrane where they connect the nucleus to the cytoskeleton. New findings have expanded the functional diversity of KASH proteins, showing that they interact with microtubule motors, actin, intermediate filaments, a nonconventional myosin, RanGAP, and each other. The role of KASH proteins in cellular mechanics is discussed. Genetic mutations in KASH proteins are associated with autism, hearing loss, cancer, muscular dystrophy and other diseases.
C1 [Luxton, G. W. Gant] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA.
[Starr, Daniel A.] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA.
RP Luxton, GWG (reprint author), Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA.
EM gwgluxton@umn.edu; dastarr@ucdavis.edu
FU National Institutes of Health NIGMS [R01 GM073874]; University of
Minnesota; Paul and Sheila Wellstone Muscular Dystrophy Center
FX DAS thanks David Fay for hosting him at the University of Wyoming,
Laramie while on sabbatical. Studies in the Starr lab are supported by
grant R01 GM073874 from the National Institutes of Health NIGMS. GWGL
thanks the members of his laboratory, Meg Titus, and Melissa Gardner for
insightful discussions. Studies in the Luxton lab are supported by start
up funding from the University of Minnesota and P30 Pilot and
Feasibility Grant from the Paul and Sheila Wellstone Muscular Dystrophy
Center.
CR Anno T, 2012, BIOCHEM BIOPH RES CO, V424, P94, DOI 10.1016/j.bbrc.2012.06.073
Attali R, 2009, HUM MOL GENET, V18, P3462, DOI 10.1093/hmg/ddp290
Autore F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063633
Borrego-Pinto J, 2012, J CELL SCI, V125, P1099, DOI 10.1242/jcs.087049
Brosig M, 2010, INT J BIOCHEM CELL B, V42, P1717, DOI 10.1016/j.biocel.2010.07.001
Bui KH, 2013, CELL, V155, P1233, DOI 10.1016/j.cell.2013.10.055
Burke B, 2009, DEV CELL, V17, P587, DOI 10.1016/j.devcel.2009.10.018
Burke B, 2012, CELL, V149, P961, DOI 10.1016/j.cell.2012.05.004
Chambliss AB, 2013, SCI REP-UK, V3, DOI 10.1038/srep01087
Chancellor TJ, 2010, BIOPHYS J, V99, P115, DOI 10.1016/j.bpj.2010.04.011
Chytilova E, 2000, MOL BIOL CELL, V11, P2733
Conrad MN, 2008, CELL, V133, P1175, DOI 10.1016/j.cell.2008.04.047
Ding X, 2007, DEV CELL, V12, P863, DOI 10.1016/j.devcel.2007.03.018
Doherty JA, 2010, CANCER EPIDEM BIOMAR, V19, P245, DOI 10.1158/1055-9965.EPI-09-0729
Fischer JA, 2004, GENETICS, V168, P1385, DOI 10.1534/genetics.104.028662
Folker ES, 2011, P NATL ACAD SCI USA, V108, P131, DOI 10.1073/pnas.1000824108
Fridolfsson HN, 2010, DEV BIOL, V338, P237, DOI 10.1016/j.ydbio.2009.12.004
Graumann K, 2009, PLANT J, V61, P134
Green EK, 2012, MOL PSYCHIAT
Gros-Louis F, 2007, NAT GENET, V39, P80, DOI 10.1038/ng1927
Gundersen GG, 2013, CELL, V152, P1376, DOI 10.1016/j.cell.2013.02.031
Hiraoka Y, 2009, DEV CELL, V17, P598, DOI 10.1016/j.devcel.2009.10.014
Horn HF, 2013, J CLIN INVEST
Horn HF, 2013, J CELL BIOL, V202, P1023, DOI 10.1083/jcb.201304004
Hutten S, 2008, MOL BIOL CELL, V19, P2300, DOI 10.1091/mbc.E07-12-1279
Iyer KV, 2012, BIOPHYS J, V103, P1416
Jaalouk DE, 2009, NAT REV MOL CELL BIO, V10, P63, DOI 10.1038/nrm2597
Khatau SB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036689
Khatau SB, 2009, P NATL ACAD SCI USA, V106, P19017, DOI 10.1073/pnas.0908686106
Khatau SB, 2010, NUCLEUS-AUSTIN, V1, P337, DOI 10.4161/nucl.1.4.12331
Kihara T, 2011, BIOCHEM BIOPH RES CO, V409, P1, DOI 10.1016/j.bbrc.2011.04.022
Kim DH, 2013, SOFT MATTER, V9, P5516, DOI 10.1039/c3sm50798j
Lee CY, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002730
Lindeman RE, 2012, CURR BIOL, V22, P843, DOI 10.1016/j.cub.2012.03.058
Lombardi ML, 2011, J BIOL CHEM, V286, P26743, DOI 10.1074/jbc.M111.233700
Lovett DB, 2013, CELL MOL BIOENG, V6, P230, DOI 10.1007/s12195-013-0270-2
Lu WS, 2012, CELL MOL LIFE SCI, V69, P3493, DOI 10.1007/s00018-012-1034-1
Luxton GWG, 2011, CURR OPIN CELL BIOL, V23, P579, DOI 10.1016/j.ceb.2011.08.001
Luxton GWG, 2010, SCIENCE, V329, P956, DOI 10.1126/science.1189072
Malone CJ, 2003, CELL, V115, P825, DOI 10.1016/S0092-8674(03)00985-1
Maniotis AJ, 1997, P NATL ACAD SCI USA, V94, P849, DOI 10.1073/pnas.94.3.849
Martins RP, 2012, ANNU REV BIOMED ENG, V14, P431, DOI [10.1146/annurev-bioeng-071910-124638, 10.1146/annurev.bioeng-071910-124638]
Mcgee MD, 2009, J CELL SCI, V122, P2895, DOI 10.1242/jcs.051607
Meyerzon M, 2009, DEVELOPMENT, V136, P2725, DOI 10.1242/dev.038596
Morgan JT, 2011, MOL BIOL CELL, V22, P4324, DOI 10.1091/mbc.E11-04-0287
Morimoto A, 2012, J CELL BIOL, V198, P165, DOI 10.1083/jcb.201204085
Murphy SP, 2012, J CELL SCI
Noreau A, 2013, JAMA NEUROL
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011, NAT GENET, V43, P977, DOI DOI 10.1038/NG.943
Rajgor D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040098
Rajgor D, 2013, EXPERT REV MOL MED, V15, DOI 10.1017/erm.2013.6
Razafsky D, 2009, J CELL BIOL, V186, P461, DOI 10.1083/jcb.200906068
Rothballer A, 2013, NUCLEUS-AUSTIN, V4, P29, DOI 10.4161/nucl.23387
Roux KJ, 2009, P NATL ACAD SCI USA, V106, P2194, DOI 10.1073/pnas.0808602106
Sato A, 2009, CELL, V139, P907, DOI 10.1016/j.cell.2009.10.039
Schoppmann SF, 2013, CLIN CANCER RES, V19, P5329, DOI 10.1158/1078-0432.CCR-12-3863
Simon DN, 2011, NAT REV MOL CELL BIO, V12, P695, DOI 10.1038/nrm3207
Sjoblom T, 2006, SCIENCE, V314, P268, DOI 10.1126/science.1133427
Sosa BA, 2013, CURR OPIN STRUC BIOL, V23, P285, DOI 10.1016/j.sbi.2013.03.005
Sosa BA, 2012, CELL, V149, P1035, DOI 10.1016/j.cell.2012.03.046
Starr DA, 2010, ANNU REV CELL DEV BI, V26, P421, DOI 10.1146/annurev-cellbio-100109-104037
Starr DA, 2011, CURR BIOL, V21, pR414, DOI 10.1016/j.cub.2011.04.022
Stewart-Hutchinson PJ, 2008, EXP CELL RES, V314, P1892, DOI 10.1016/j.yexcr.2008.02.022
Tamura K, 2013, CURR BIOL
Tapley EC, 2012, CURR OPIN CELL BIOL
Tikhonenko I, 2009, EUKARYOT CELL, V8, P723, DOI 10.1128/EC.00018-09
Tikhonenko I, 2013, CELL MOL LIFE SCI, V70, P1285, DOI 10.1007/s00018-012-1205-0
Wang N, 2009, NAT REV MOL CELL BIO, V10, P75, DOI 10.1038/nrm2594
Wang W, 2012, CELL RES
Worman HJ, 2012, J PATHOL, V226, P316, DOI 10.1002/path.2999
Xu XM, 2007, CURR BIOL, V17, P1157, DOI 10.1016/j.cub.2007.05.076
Yoshida M, 2013, J CELL BIOL
Yu JH, 2011, HUM MOL GENET, V20, P1061, DOI 10.1093/hmg/ddq549
Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
Zhang QP, 2007, HUM MOL GENET, V16, P2816, DOI 10.1093/hmg/ddm238
Zhang XC, 2009, NEURON, V64, P173, DOI 10.1016/j.neuron.2009.08.018
Zhao Q, 2008, PLANT CELL, V20, P1639, DOI 10.1105/tpc.108.059220
Zhou X, 2013, NUCLEUS-AUSTIN, V4, P206, DOI 10.4161/nucl.24088
Zhou X, 2012, J CELL BIOL, V196, P203, DOI 10.1083/jcb.201108098
NR 80
TC 8
Z9 8
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0955-0674
EI 1879-0410
J9 CURR OPIN CELL BIOL
JI Curr. Opin. Cell Biol.
PD JUN
PY 2014
VL 28
BP 69
EP 75
DI 10.1016/j.ceb.2014.03.002
PG 7
WC Cell Biology
SC Cell Biology
GA AK7NE
UT WOS:000338614200010
PM 24704701
ER
PT J
AU Savoy, M
AF Savoy, Margot
TI Autism 5 misconceptions that can complicate care
SO JOURNAL OF FAMILY PRACTICE
LA English
DT Article
ID SPECTRUM DISORDERS; YOUNG-ADULTS; CHILDREN; INTERVENTION; TODDLERS
C1 [Savoy, Margot] Thomas Jefferson Univ, Jefferson Med Coll, Dept Family & Community Med, Philadelphia, PA 19107 USA.
RP Savoy, M (reprint author), Christiana Care Hlth Syst, Dept Family & Community Med, 1401 Foulk Rd,Suite 100B, Wilmington, DE 19803 USA.
EM msavoy@christianacare.org
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Anderson KA, 2013, AUTISM
[Anonymous], SCREEN AUT SPECTR DI
Centers for Disease Control and Prevention, IMM SAF AUT
Henley SJ, 2014, MMWR-MORBID MORTAL W, V63, P1
Centers for Disease Control and Prevention, 1999, MMWR-MORBID MORTAL W, V48, P563
Cheuk DKL, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007849.pub2
Milllward C, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003498.pub3
Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dove D, 2012, PEDIATRICS, V130, P717, DOI 10.1542/peds.2012-0683
Edelson M. G., 2006, FOCUS AUTISM OTHER D, V21, P66, DOI DOI 10.1177/10883576060210020301
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
James S, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007992.pub2
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
Oono IP, 2013, COCHRANE DB SYST REV, V4
Orsmond GI, 2013, J AUTISM DEV DISORD, V43, P2710, DOI 10.1007/s10803-013-1833-8
Reichow B, 2012, COCHRANE DB SYST REV, V10
Robins DL, 2014, PEDIATRICS, V133, P37, DOI 10.1542/peds.2013-1813
Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
Roux AM, 2013, J AM ACAD CHILD PSY, V52, P931, DOI 10.1016/j.jaac.2013.05.019
Sinha Y, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003681.pub3
Sochocky Natalie, 2013, Curr Clin Pharmacol, V8, P370
Uhlmann V, 2002, J CLIN PATHOL-MOL PA, V55, P84
Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
Williams K, 2012, COCHRANE DB SYST REV, V4
NR 30
TC 0
Z9 0
PU DOWDEN HEALTH MEDIA
PI MONTVALE
PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA
SN 0094-3509
J9 J FAM PRACTICE
JI J. Fam. Pract.
PD JUN
PY 2014
VL 63
IS 6
BP 310
EP 314
PG 5
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AK2YA
UT WOS:000338285100009
PM 25061620
ER
PT J
AU Zylstra, RG
Prater, CD
Walthour, AE
Aponte, AF
AF Zylstra, Robert G.
Prater, Christopher D.
Walthour, Amy E.
Aponte, Alexandra Feliciano
TI Autism Why the rise in rates?
SO JOURNAL OF FAMILY PRACTICE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; DIAGNOSTIC
INTERVIEW; MODIFIED CHECKLIST; YOUNG-CHILDREN; PREVALENCE; INSTRUMENT;
CHILDHOOD; TODDLERS; CHAT
C1 [Zylstra, Robert G.; Prater, Christopher D.; Walthour, Amy E.] Univ Tennessee, Coll Med, Dept Family Med, Chattanooga, TN 37403 USA.
[Aponte, Alexandra Feliciano] Mayo Clin, Jacksonville, FL 32224 USA.
RP Zylstra, RG (reprint author), Univ Tennessee, Coll Med, Dept Family Med, 110 East Third St, Chattanooga, TN 37403 USA.
EM robert.zylstra@erlanger.org
CR American Psychiatric Association, 1968, DIAGN STAT MAN MENT
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1987, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
American Psychiatric Association, 1980, DIAGN STAT MAN MENT
American Psychiatric Association, 1952, DIAGN STAT MAN MENT
[Anonymous], REP LEG PRINC FIND E
[Anonymous], GREAT THIM COV UP ME
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Autism ALARM, AUT ALARM
BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
Bettelheim B., 1972, EMPTY FORTRESS INFAN
Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
Fine R, 2014, MOL PSYCHIAT
Flatscher-Bader T, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.30
Fombonne E, 2006, PEDIATRICS, V118, pE139, DOI 10.1542/peds.2005-2993
Frith U, 1991, AUTISM ASPERGER SYND
Ghaziuddin M, 2010, J AUTISM DEV DISORD, V40, P1146, DOI 10.1007/s10803-010-0969-z
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
Joshi G, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-204
Kanner L, 1943, NERV CHILD, V2, P217
KANNER L, 1965, BEHAV SCI, V10, P412, DOI 10.1002/bs.3830100404
Kong SW, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049475
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Nassar N, 2009, INT J EPIDEMIOL, V38, P1245, DOI 10.1093/ije/dyp260
Parks SE, 2014, MMWR SURVEILL SUMM, V63, P1
Prater CD, 2002, AM FAM PHYSICIAN, V66, P1667
Price CS, 2010, PEDIATRICS, V126, P656, DOI 10.1542/peds.2010-0309
Rimland B., 1964, INFANTILE AUTISM SYN
Robins DL, 2014, PEDIATRICS, V133, P37, DOI 10.1542/peds.2013-1813
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Shattuck PT, 2006, PEDIATRICS, V117, P1028, DOI 10.1542/peds.2005-1516
Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
Zwaigenbaum L, 2010, CURR OPIN NEUROL, V23, P97, DOI 10.1097/WCO.0b013e3283372430
NR 41
TC 0
Z9 0
PU DOWDEN HEALTH MEDIA
PI MONTVALE
PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA
SN 0094-3509
J9 J FAM PRACTICE
JI J. Fam. Pract.
PD JUN
PY 2014
VL 63
IS 6
BP 316
EP 320
PG 5
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AK2YA
UT WOS:000338285100010
PM 25061621
ER
PT J
AU McClintic, AM
King, BH
Webb, SJ
Mourad, PD
AF McClintic, Abbi M.
King, Bryan H.
Webb, Sara J.
Mourad, Pierre D.
TI Mice Exposed to Diagnostic Ultrasound In Utero Are Less Social and More
Active in Social Situations Relative to Controls
SO AUTISM RESEARCH
LA English
DT Article
DE diagnostic ultrasound; mouse social behavior; autistic-like behavior;
risk factor
ID AUTISM SPECTRUM DISORDERS; RANDOMIZED CONTROLLED-TRIAL; BEHAVIORAL TASKS
RELEVANT; PRENATAL ULTRASOUND; FETAL PERIOD; FOLLOW-UP; MOUSE; RISK;
AGE; ASSOCIATION
AB Clinical use of diagnostic ultrasound imaging during pregnancy has a long history of safety and diagnostic utility, as supported by numerous human case reports and epidemiological studies. However, there exist in vivo studies linking large but clinically relevant doses of ultrasound applied to mouse fetuses in utero to altered learning, memory, and neuroanatomy of those mice. Also, there exists a well-documented significant increase in the likelihood of non-right-handedness in boys exposed to diagnostic ultrasound in utero, potentially relevant given the increased prevalence of autism in males, and reports of excess non-right-handedness in this population. Motivated by these observations, we applied 30minutes of diagnostic ultrasound to pregnant mice at embryonic day 14.5 and assayed the social behavior of their male pups 3 weeks after their birth. The ultrasound-exposed pups were significantly (P<0.01) less interested in social interaction than sham-exposed pups in a three-chamber sociability test. In addition, they demonstrated significantly (P<0.05) more activity relative to the sham-exposed pups, but only in the presence of an unfamiliar mouse. These results suggest that fetal exposure to diagnostic ultrasound applied in utero can alter typical social behaviors in young mice that may be relevant for autism. There exist meaningful differences between the exposure of diagnostic ultrasound to mice versus humans that require further exploration before this work can usefully inform clinical practice. Future work should address these differences as well as clarify the extent, mechanisms, and functional effects of diagnostic ultrasound's interaction with the developing brain. Autism Res 2014, 7: 295-304. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [McClintic, Abbi M.; Mourad, Pierre D.] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA.
[King, Bryan H.] Seattle Childrens Hosp, Seattle Childrens Autism Ctr, Seattle, WA USA.
[King, Bryan H.] Seattle Childrens Hosp, Seattle, WA USA.
[King, Bryan H.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Webb, Sara J.] Univ Washington, Seattle, WA 98195 USA.
[Webb, Sara J.] Univ Washington, Autism Ctr, Seattle, WA 98195 USA.
[Webb, Sara J.] Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA.
[Mourad, Pierre D.] Univ Washington, Appl Phys Lab, Dept Engn & Math, Seattle, WA 98195 USA.
[Mourad, Pierre D.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
RP Mourad, PD (reprint author), Univ Washington, Dept Neurol Surg, Box 356470, Seattle, WA 98195 USA.
EM pierre@apl.washington.edu
FU National Institute of Child Health and Human Development [P30 HD002274]
FX We thank the Mouse Behavior Core in the Center for Human Development and
Disability at the University of Washington, supported by grant P30
HD002274 from the National Institute of Child Health and Human
Development, for the resources to perform the behavioral studies. We
also thank Dr. Sean Murphy and Dr. Toby Cole, who manage the Mouse
Behavior Core for their considerable assistance.
CR Abramowicz JS, 2007, ULTRASOUND OBST GYN, V29, P363, DOI 10.1002/uog.3983
Abramowicz JS, 2012, J ULTRAS MED, V31, P1261
Ang ESBC, 2006, P NATL ACAD SCI USA, V103, P12903, DOI 10.1073/pnas.0605294103
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILLANCE SU, V61, P1
Center for Devices and Radiological Health, 1997, INF MAN SEEK MARK CL
Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
Dane S, 2007, INT J DEV NEUROSCI, V25, P223, DOI 10.1016/j.ijdevneu.2007.03.005
DEVI PU, 1995, RADIAT RES, V141, P314, DOI 10.2307/3579009
Fatemi M, 2001, J ULTRAS MED, V20, P883
FDA, 2013, AV FET KEEPS IM HEAR
Gibbs V., 2009, ULTRASOUND PHYS TECH, P94
Grether JK, 2010, J AUTISM DEV DISORD, V40, P238, DOI 10.1007/s10803-009-0859-4
Hinoue A, 2001, DEV BRAIN RES, V132, P59, DOI 10.1016/S0165-3806(01)00295-4
Interagency Autism Coordinating Committee (IACC), 2012, IACC STRAT PLAN AUT
JENSH RP, 1995, P SOC EXP BIOL MED, V210, P171
Kalil K, 2011, FRONT NEUROANAT, V5, DOI 10.3389/fnana.2011.00062
Kaufman M. H., 1999, ANATOMICAL BASIS MOU, P171, DOI 10.1016/B978-012402060-3/50037-4
Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
Lampi KM, 2013, J AUTISM DEV DISORD, V43, P2526, DOI 10.1007/s10803-013-1801-3
Lyall K, 2012, AUTISM RES, V5, P21, DOI 10.1002/aur.228
Matson JL, 2013, RES DEV DISABIL, V34, P2475, DOI 10.1016/j.ridd.2013.05.021
Mourad P. D., 2012, ULTRASONIC TRANSDUCE, P454
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Rados Carol, 2004, FDA Consum, V38, P12
Salvesen Kjell A, 2002, Eur J Ultrasound, V15, P165, DOI 10.1016/S0929-8266(02)00038-1
Salvesen KA, 2007, PROG BIOPHYS MOL BIO, V93, P295, DOI 10.1016/j.pbiomolbio.2006.07.013
Sandin S, 2012, J AM ACAD CHILD PSY, V51, P477, DOI 10.1016/j.jaac.2012.02.018
SOPER HV, 1986, J AUTISM DEV DISORD, V16, P155, DOI 10.1007/BF01531727
Stalberg K, 2009, ULTRASOUND OBST GYN, V34, P297, DOI 10.1002/uog.7332
STEWART HD, 1985, J CLIN ULTRASOUND, V13, P167, DOI 10.1002/jcu.1870130304
Stoch YK, 2012, J AUTISM DEV DISORD, V42, P2693, DOI 10.1007/s10803-012-1526-8
Suresh R, 2008, ANN ANAT, V190, P37, DOI 10.1016/j.aanat.2007.04.008
Suresh R, 2002, LIFE SCI, V71, P339, DOI 10.1016/S0024-3205(02)01642-9
ter Haar GR, 2013, ULTRASOUND MED BIOL, V39, P374, DOI 10.1016/j.ultrasmedbio.2012.11.024
Tufail Y, 2010, NEURON, V66, P681, DOI 10.1016/j.neuron.2010.05.008
Vorhees C. V., 1986, HDB BEHAV TERATOLOGY, P23
Whitworth M., 2010, COCHRANE DB SYST REV, V4, P1
Williams EL, 2010, MED HYPOTHESES, V75, P53, DOI 10.1016/j.mehy.2010.01.027
Williams EL, 2013, TRANSL NEUROSCI, V4, P81, DOI 10.2478/s13380-013-0112-7
Yang M., 2011, CURRENT PROTOCOL S56, V56
Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x
NR 41
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2014
VL 7
IS 3
BP 295
EP 304
DI 10.1002/aur.1349
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AJ9KD
UT WOS:000338027900001
PM 24249575
ER
PT J
AU Dalton, N
Chandler, S
Turner, C
Charman, T
Pickles, A
Loucas, T
Simonoff, E
Sullivan, P
Baird, G
AF Dalton, Neil
Chandler, Susie
Turner, Charles
Charman, Tony
Pickles, Andrew
Loucas, Tom
Simonoff, Emily
Sullivan, Peter
Baird, Gillian
TI Gut Permeability in Autism Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE autism; autism spectrum disorders; gut permeability; lactulose; mannitol
ratio
ID INTESTINAL PERMEABILITY; GASTROINTESTINAL SYMPTOMS; CHILDREN; DISEASE;
INDIVIDUALS; ASSOCIATION; PREVALENCE; LACTULOSE; MANNITOL; FAMILIES
AB Objective To test whether gut permeability is increased in autism spectrum disorders (ASD) by evaluating gut permeability in a population-derived cohort of children with ASD compared with age- and intelligence quotient-matched controls without ASD but with special educational needs (SEN). Patients and Methods One hundred thirty-three children aged 10-14 years, 103 with ASD and 30 with SEN, were given an oral test dose of mannitol and lactulose and urine collected for 6hr. Gut permeability was assessed by measuring the urine lactulose/mannitol (L/M) recovery ratio by electrospray mass spectrometry-mass spectrometry. The ASD group was subcategorized for comparison into those without (n=83) and with (n=20) regression. Results There was no significant difference in L/M recovery ratio (mean (95% confidence interval)) between the groups with ASD: 0.015 (0.013-0.018), and SEN: 0.014 (0.009-0.019), nor in lactulose, mannitol, or creatinine recovery. No significant differences were observed in any parameter for the regressed versus non-regressed ASD groups. Results were consistent with previously published normal ranges. Eleven children (9/103=8.7% ASD and 2/30=6.7% SEN) had L/M recovery ratio >0.03 (the accepted normal range cut-off), of whom two (one ASD and one SEN) had more definitely pathological L/M recovery ratios >0.04. Conclusion There is no statistically significant group difference in small intestine permeability in a population cohort-derived group of children with ASD compared with a control group with SEN. Of the two children (one ASD and one SEN) with an L/M recovery ratio of >0.04, one had undiagnosed asymptomatic celiac disease (ASD) and the other (SEN) past extensive surgery for gastroschisis. Autism Res 2014, 7: 305-313. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Dalton, Neil; Turner, Charles] Evelina Childrens Hosp, WellChild Lab, London, England.
[Dalton, Neil; Turner, Charles] Kings Coll London, London WC2R 2LS, England.
[Chandler, Susie; Baird, Gillian] Guys & St Thomas NHS Fdn Trust, Newcomen Ctr, London, England.
[Chandler, Susie; Charman, Tony; Pickles, Andrew; Simonoff, Emily; Baird, Gillian] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
[Loucas, Tom] Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 2AH, Berks, England.
[Sullivan, Peter] Univ Oxford, Dept Paediat, Oxford Childrens Hosp, Oxford OX1 2JD, England.
RP Baird, G (reprint author), St Thomas Hosp, Childrens Neurosci Ctr, Block D,Westminster Bridge Rd, London SE1 7EH, England.
EM gillian.baird@gstt.nhs.uk
RI Pickles, Andrew/A-9625-2011
OI Pickles, Andrew/0000-0003-1283-0346
FU Wellcome Trust [GR045093MA]; Department of Health [039/0026]; Remedi
[22]
FX The study was funded as follows:Grant sponsor: Wellcome Trust; Grant
number: GR045093MA; Grant sponsor: the Department of Health; Grant
number: 039/0026; Grant sponsor: Remedi; Grant number: 22
CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baird G, 2008, J AUTISM DEV DISORD, V38, P1827, DOI 10.1007/s10803-008-0571-9
BJARNASON I, 1995, GASTROENTEROLOGY, V108, P1566, DOI 10.1016/0016-5085(95)90708-4
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D
Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819
Chandler S, 2013, J AUTISM DEV DISORD, V43, P2737, DOI 10.1007/s10803-013-1768-0
de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
DEufemia P, 1996, ACTA PAEDIATR, V85, P1076, DOI 10.1111/j.1651-2227.1996.tb14220.x
Erickson CA, 2005, J AUTISM DEV DISORD, V35, P713, DOI 10.1007/s10803-005-0019-4
Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
Halme L, 2000, SCAND J CLIN LAB INV, V60, P695, DOI 10.1080/00365510050216420
Horvath Karoly, 2002, Curr Gastroenterol Rep, V4, P251, DOI 10.1007/s11894-002-0071-6
Horvath Karoly, 2000, JPGN, V31, pS30
Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
Knivsberg AM, 2002, NUTR NEUROSCI, V5, P251, DOI 10.1080/10281450290028945
LECOUTEUR A, 1988, J AUTISM DEV DISORD, V18, P181
Levy SE, 2008, CHILD ADOL PSYCH CL, V17, P803, DOI 10.1016/j.chc.2008.06.004
Liu Z, 2005, ACTA PAEDIATR, V94, P386, DOI 10.1080/08035250410023304
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Marsilio R, 1998, CLIN CHEM, V44, P1685
Millward C, 2004, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003498.PUB2
PANKSEPP J, 1979, TRENDS NEUROSCI, V2, P174, DOI 10.1016/0166-2236(79)90071-7
Raven JC, 1990, COLOURED PROGR MATRI
Raven John C., 1990, STANDARD PROGR MATRI
REICHELT K-L, 1990, Journal of Applied Nutrition, V42, P1
Reichelt K L, 1981, Adv Biochem Psychopharmacol, V28, P627
Robertson MA, 2008, J AUTISM DEV DISORD, V38, P1066, DOI 10.1007/s10803-007-0482-1
Rutter M., 2003, SCQ SOCIAL COMMUNICA
Shattock Paul, 2002, Expert Opin Ther Targets, V6, P175
Shattock Paul, 1991, Brain Dysfunction, V4, P323
Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418
Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
Vickery S, 2006, NEPHROL DIAL TRANSPL, V21, P2439, DOI 10.1093/ndt/gfl249
Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a
Wechsler D., 1992, WECHSLER INTELLIGENC
WYATT J, 1993, LANCET, V341, P1437, DOI 10.1016/0140-6736(93)90882-H
NR 38
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2014
VL 7
IS 3
BP 305
EP 313
DI 10.1002/aur.1350
PG 9
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AJ9KD
UT WOS:000338027900002
PM 24339339
ER
PT J
AU Stockbridge, MD
Happe, FGE
White, SJ
AF Stockbridge, Melissa D.
Happe, Francesca G. E.
White, Sarah J.
TI Impaired Comprehension of Alternating Syntactic Constructions in Autism
SO AUTISM RESEARCH
LA English
DT Article
DE autism; language development; syntax; dative alternation
ID SPECTRUM DISORDERS; DATIVE ALTERNATION; LANGUAGE PROFILES;
COGNITIVE-STYLE; CHILDREN; ENGLISH
AB Individuals on the higher-functioning end of the autism spectrum have significant impairments in communication. Language delay can occur, particularly in syntactic or structural linguistic knowledge. However, classically observed semantic deficits generally overshadow these structural deficits. This research examined the potential effects on comprehension of dative expressions that exhibited syntactic alternation versus those that were restricted, whether in syntactic construction or through marked semantic differences in construction. Children with autism and matched neurotypical control participants were presented with a sentence battery of dative statements representing these variations in construction and were asked to display basic comprehension of the sentence meaning by identifying the recipient, or indirect object, of the dative verb. Construction, restriction, and semantic differentiation variables were analyzed for potential effects on the rate of accurate comprehension. Both groups performed with greater accuracy when dative expressions used a prepositional phrase than when the dative action was expressed in the syntax. The autism group performed more poorly when the dative expression could syntactically alternate than when it was restricted. These effects improve our knowledge of how children with autism understand alternating grammatical constructions. Autism Res 2014, 7: 314-321. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Stockbridge, Melissa D.; White, Sarah J.] UCL, Inst Cognit Neurosci, London WC1N 3AR, England.
[Happe, Francesca G. E.] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
RP White, SJ (reprint author), UCL, Inst Cognit Neurosci, 17 Queen Sq, London WC1N 3AR, England.
EM s.white@ucl.ac.uk
RI White, Sarah/C-4084-2008
OI White, Sarah/0000-0001-6946-9155
FU British Academy Fellowship [PDF/2009/213]
FX Grant sponsors: This work was supported by a British Academy Fellowship
PDF/2009/213 to S. J. W.
CR Anderson J. M., 1971, GRAMMAR CASE
Baron-Cohen S, 1999, DEV COGN NEUROSCI, P401
Bartlett SC, 2005, CLIN LINGUIST PHONET, V19, P203, DOI 10.1080/02699200410001698634
Brysbaert M, 2009, BEHAV RES METHODS, V41, P977, DOI 10.3758/BRM.41.4.977
Caplan D., 1988, DISORDERS SYNTACTIC
Chomsky N., 1965, ASPECTS THEORY SYNTA
Conwell E, 2007, COGNITION, V103, P163, DOI 10.1016/j.cognition.2006.03.003
DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777
Demuth K, 2005, LANGUAGE, V81, P421, DOI 10.1353/lan.2005.0056
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2
Eigsti IM, 2009, J CHILD LANG, V36, P999, DOI 10.1017/S0305000909009362
FINE J, 1991, J CHILD PSYCHOL PSYC, V32, P771, DOI 10.1111/j.1469-7610.1991.tb01901.x
Frith U., 1989, AUTISM EXPLAINING EN
Geurts HM, 2008, J AUTISM DEV DISORD, V38, P1931, DOI 10.1007/s10803-008-0587-1
GOLINKOFF RM, 1987, J CHILD LANG, V14, P23
Green G., 1974, SEMANTICS SYNTACTIC
GROPEN J, 1989, LANGUAGE, V65, P203, DOI 10.2307/415332
Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Hovav MR, 2008, J LINGUIST, V44, P129, DOI 10.1017/S0022226707004975
Jackendoff Ray, 1983, SEMANTICS COGNITION
Jackendoff Ray S., 1972, SEMANTIC INTERPRETAT
Krifka M., 2001, DIP C AMST
Krifka M., 1999, W COAST C FORM LING
LARSON RK, 1988, LINGUIST INQ, V19, P335
Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327
Naigles Letitia R., 1990, J CHILD LANG, V172, P357, DOI DOI 10.1017/S0305000900013817
O'Grady W., 1987, PRINCIPLES GRAMMER L
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
Pesetsky David, 1995, ZERO SYNTAX
Philofsky A, 2007, AM J SPEECH-LANG PAT, V16, P368, DOI 10.1044/1058-0360(2007/040)
Pinker S., 1984, LANGUAGE LEARNABILIT
Pinker Steven, 1989, LEARNABILITY COGNITI
PRIOR M, 1990, J AUTISM DEV DISORD, V20, P581, DOI 10.1007/BF02216063
Saldana D, 2007, J EXP CHILD PSYCHOL, V96, P310, DOI 10.1016/j.jecp.2006.11.002
TAGERFLUSBERG H, 1981, J AUTISM DEV DISORD, V11, P45, DOI 10.1007/BF01531340
Tek S., 2008, AUTISM RES, V1, P202
Wasow Thomas, 2002, POSTVERBAL BEHAV
Waxman SR, 2009, COGNITIVE PSYCHOL, V59, P67, DOI 10.1016/j.cogpsych.2009.02.001
Wechsler D., 1992, WECHSLER INTELLIGENC
NR 44
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2014
VL 7
IS 3
BP 314
EP 321
DI 10.1002/aur.1348
PG 8
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AJ9KD
UT WOS:000338027900003
PM 24227788
ER
PT J
AU Lane, AE
Molloy, CA
Bishop, SL
AF Lane, Alison E.
Molloy, Cynthia A.
Bishop, Somer L.
TI Classification of Children With Autism Spectrum Disorder by Sensory
Subtype: A Case for Sensory-Based Phenotypes
SO AUTISM RESEARCH
LA English
DT Article
DE sensory; autism; phenotypes; subtypes; children; classification;
model-based cluster analysis; Short Sensory Profile
ID DEVELOPMENTAL DELAYS; TYPICAL DEVELOPMENT; YOUNG-CHILDREN; BEHAVIORS;
ABNORMALITIES; MOTOR; INTEGRATION; RESPONSES; PATTERNS; FEATURES
AB This study examines whether sensory differences can be used to classify meaningful subgroups of children with autism spectrum disorder (ASD). Caregivers of children with ASD aged 2-10 years (n=228) completed the Short Sensory Profile. Model-based cluster analysis was used to extract sensory subtypes. The relationship of these subtypes to age, gender, autism symptom severity, and nonverbal intelligence quotient (IQ) was further explored. Four distinct sensory subtypes were identified: (a) sensory adaptive; (b) taste smell sensitive; (c) postural inattentive; and (d) generalized sensory difference. The sensory subtypes differ from each other on two dimensions: (a) the severity of reported sensory differences; and (b) the focus of differences across auditory, taste, smell, vestibular and proprioceptive domains. Examination of the clinical features of each subtype reveals two possible mechanisms of sensory disturbance in autism: (a) sensory hyperreactivity; and (b) difficulties with multisensory processing. Further, the sensory subtypes are not well explained by other variables such as age, gender, IQ, and autism symptom severity. We conclude that classification of children using sensory differences offers a promising method by which to identify phenotypes in ASD. Sensory-based phenotypes may be useful in identifying behavioral features responsive to specific interventions thereby improving intervention effectiveness. Further validation of the sensory-based phenotypes by establishing neural and physiological correlates is recommended. Autism Res 2014, 7: 322-333. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Lane, Alison E.] Univ Newcastle, Sch Hlth Sci, Callaghan, NSW 2308, Australia.
[Molloy, Cynthia A.] Harrison Community Network, Harrison, OH USA.
[Bishop, Somer L.] Weill Cornell Med Coll, CADB, White Plains, NY USA.
RP Lane, AE (reprint author), Univ Newcastle, Sch Hlth Sci, Univ Dr, Callaghan, NSW 2308, Australia.
EM alison.lane@newcastle.edu.au
FU U.S. Department of Health and Human Services, Health Resources and
Services Administration, Maternal and Child Health Research Program [UA3
MC 11054]; [R01HD065277]
FX The authors acknowledge the members of the Autism Speaks Autism
Treatment Network (AS ATN) for use of the data. The data for the study
was collected as part of the AS ATN. Further support came from a
cooperative agreement (UA3 MC 11054) from the U.S. Department of Health
and Human Services, Health Resources and Services Administration,
Maternal and Child Health Research Program, to the Massachusetts General
Hospital. The AS ATN includes these members: Cincinnati Children's
Hospital Medical Center, Patricia Manning-Courtney, MD. The views
expressed in this publication do not necessarily reflect the views of
the Autism Speaks, Inc.Other acknowledgments: Dr. Bishop received
support from R01HD065277. Simon Dennis, Terri Mitchell, Carrie Thomas,
Chelsea Hetrick, Kerry Dalton, Kelly Tanner, Brittany Hand, Andrew
Persch, Marisa Capogreco
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Ausderau K, 2014, J AUTISM DEV DISORD, V44, P915, DOI 10.1007/s10803-013-1945-1
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Begovac I, 2009, PSYCHIAT DANUB, V21, P310
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Ben-Sasson A, 2007, AM J OCCUP THER, V61, P584
Bishop SL, 2013, J AUTISM DEV DISORD, V43, P1287, DOI 10.1007/s10803-012-1671-0
Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331
Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124
Center for the Study of Language and Information Stanford University, 2013, STANFORD ENCY PHILOS
Clifford SM, 2013, J AUTISM DEV DISORD, V43, P673, DOI 10.1007/s10803-012-1612-y
Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103
Fraley Chris, 2007, J STAT SOFTW, V18, P1
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
Hilton C, 2007, RES AUTISM SPECT DIS, V1, P164, DOI 10.1016/j.rasd.2006.10.002
Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724
Izawa J, 2012, AUTISM RES, V5, P124, DOI 10.1002/aur.1222
Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564
Koenig K. P., 2008, SPECIAL INTEREST SEC, V31, P3
Lane A. E., ROBLEM EATI IN PRESS
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y
Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2001, AM J MED GENET, V105, P36, DOI 10.1002/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4
Marco EJ, 2011, PEDIATR RES, V69, p48R, DOI [10.1203/PDR.0b013e3182130c54, 10.1109/SPL.2011.5782616]
Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
McIntosh DN, 1999, DEV MED CHILD NEUROL, V41, P608, DOI 10.1017/S0012162299001267
Miller LJ, 2007, AM J OCCUP THER, V61, P135
Mullen E, 1995, MULLEN SCALES EARLY
Reynolds S, 2011, J AUTISM DEV DISORD, V41, P1496, DOI 10.1007/s10803-010-1173-x
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
Roid G. H., 2003, STANFORD BINET INTEL
Sober SJ, 2003, J NEUROSCI, V23, P6982
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
Zhong S, 2003, J MACHINE LEARNING R, V4, P1001, DOI 10.1162/jmlr.2003.4.6.1001
NR 41
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2014
VL 7
IS 3
BP 322
EP 333
DI 10.1002/aur.1368
PG 12
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AJ9KD
UT WOS:000338027900004
PM 24639147
ER
PT J
AU Carson, AM
Salowitz, NMG
Scheidt, RA
Dolan, BK
Van Hecke, AV
AF Carson, Audrey M.
Salowitz, Nicole M. G.
Scheidt, Robert A.
Dolan, Bridget K.
Van Hecke, Amy V.
TI Electroencephalogram Coherence in Children With and Without Autism
Spectrum Disorders: Decreased Interhemispheric Connectivity in Autism
SO AUTISM RESEARCH
LA English
DT Article
DE electroencephaolography; EEG coherence; school age2.0.CO;2
Arbuckle J. L., 2006, AMOS VERSION 7 0 COM
Bellin MH, 2009, J FAM PSYCHOL, V23, P39, DOI 10.1037/a0014381
Cox MJ, 1997, ANNU REV PSYCHOL, V48, P243, DOI 10.1146/annurev.psych.48.1.243
Cuskelly M, 2003, AM J MENT RETARD, V108, P234, DOI 10.1352/0895-8017(2003)108<234:SROCWD>2.0.CO;2
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Kaminsky L, 2001, J AUTISM DEV DISORD, V31, P399, DOI 10.1023/A:1010664603039
Kenny D. A., 2006, DYADIC DATA ANAL
Khanna R, 2012, AUTISM, V16, P179, DOI 10.1177/1362361311406143
Leonardelli G., 2006, CALCULATION SOBEL TE
Mulroy S, 2008, J INTELL DISABIL RES, V52, P216, DOI 10.1111/j.1365-2788.2007.01005.x
Rivers JW, 2003, J AUTISM DEV DISORD, V33, P383, DOI 10.1023/A:1025006727395
ROBINSON BC, 1983, J GERONTOL, V38, P344
Schaefer E. S., 1981, SIBLING INVENTORY BE
Stoneman Z, 2005, MENT RETARD, V43, P339
NR 15
TC 0
Z9 0
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1091-7527
EI 1939-0602
J9 FAM SYST HEALTH
JI Fam. Syst. Health
PD JUN
PY 2014
VL 32
IS 2
BP 241
EP 246
DI 10.1037/fsh0000047
PG 6
WC Health Care Sciences & Services; Family Studies; Public, Environmental &
Occupational Health
SC Health Care Sciences & Services; Family Studies; Public, Environmental &
Occupational Health
GA AJ8HI
UT WOS:000337943600020
PM 24818514
ER
PT J
AU Dalsgaard, S
Leckman, JF
Nielsen, HS
Simonsen, M
AF Dalsgaard, Soren
Leckman, James F.
Nielsen, Helena Skyt
Simonsen, Marianne
TI Gender and Injuries Predict Stimulant Medication Use
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; CHILDHOOD BEHAVIOR DISORDERS; TRAUMATIC BRAIN-INJURY;
UNINTENTIONAL INJURY; INCREASED RISK; DRUG-USE; CHILDREN; POPULATION;
PREVALENCE
AB Objective: The purpose of this article was to examine whether injuries in early childhood and gender predict prescriptions of stimulant medication in three groups of children: With attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and other psychiatric disorders (OPD). Methods: This was a population-based study with prospective and complete follow-up of children with ADHD (n=11,553), ASD (n=9698), and OPD (n=48,468), of whom 61%, 16%, and 3%, respectively, were treated with stimulants. For all 69,719 individual children data on psychiatric diagnoses, injuries, and drug prescriptions were obtained from national registers and merged. Results: Having sustained an injury before 5 years of age increased the likelihood of later stimulant treatment, in children with ADHD (odds ratio [OR]=1.09; 95% confidence interval [CI]=1.01-1.21), ASD (OR=1.19; 95% CI=1.02-1.40), and OPD (OR=1.24; 95% CI=1.08-1.42), with each injury increasing the likelihood by 3%, 10%, and 7%, respectively. Head injury did not increase the likelihood of later stimulant treatment. Within each of the three groups, ADHD, ASD, and OPD boys were more likely than girls to receive stimulant medication, OR=1.17 (95% CI=1.07-1.28); OR=1.71 (95% CI=1.47-2.01), and OR=2.41 (95% CI=2.16-2.71), respectively. Conclusions: To our knowledge, this is the first prospective study assessing early life predictors of later ADHD medication in children with a psychiatric disorder, taken from a national cohort with complete follow-up of all cases. We found that the number of injuries prior to diagnosis was associated with initiation of stimulant treatment in all three groups of patients. In addition, male gender predicted treatment with ADHD medications. Our results suggest that the number of injuries early in life prior to diagnosis is associated with stimulant treatment, and may serve as a proxy for the level of later severity of ADHD symptoms, as it is universally associated with pharmacological treatment for ADHD.
C1 [Dalsgaard, Soren] Aarhus Univ, Dept Econ & Business, Natl Ctr Register Based Res, DK-8210 Aarhus V, Denmark.
[Dalsgaard, Soren] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Aarhus, Denmark.
[Dalsgaard, Soren] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Copenhagen, Denmark.
[Dalsgaard, Soren] Hosp Telemark, Dept Child & Adolescent Psychiat, Kragero, Norway.
[Leckman, James F.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
[Nielsen, Helena Skyt; Simonsen, Marianne] Aarhus Univ, Sch Business & Social Sci, Deparment Econ & Business, DK-8210 Aarhus V, Denmark.
RP Dalsgaard, S (reprint author), Aarhus Univ, Natl Ctr Register Ased Res, Fuglesangs Alle 4,Bldg K, DK-8210 Aarhus V, Denmark.
EM sdalsgaard@ncrr.dk
FU Lundbeck Foundation; Danish Council for Independent Research
[10-079597]; Slagtermester Max Worzner and Inger Worzners Foundation
FX The study was funded by grants from the Lundbeck Foundation, the Danish
Council for Independent Research (Sapere Aude Starting Grant, 10-079597)
and Slagtermester Max Worzner and Inger Worzners Foundation.
CR Andersen TF, 1999, DAN MED BULL, V46, P263
Ban E, 2014, EUR CHILD ADOLES PSY, V23, P95
Brault MC, 2012, CAN J PSYCHIAT, V57, P93
Brehaut JC, 2003, PEDIATRICS, V111, P262, DOI 10.1542/peds.111.2.262
Bruce B, 2007, PAED CHILD HEALT-CAN, V12, P749
Bruckner TA, 2012, PHARMACOEPIDEM DR S, V21, P442, DOI 10.1002/pds.2264
Byrne JM, 2003, CHILD NEUROPSYCHOL, V9, P142, DOI 10.1076/chin.9.2.142.14501
Castle Lon, 2007, J Atten Disord, V10, P335, DOI 10.1177/1087054707299597
Chen CY, 2011, J CHILD ADOL PSYCHOP, V21, P265, DOI 10.1089/cap.2010.0107
Cox ER, 2003, PEDIATRICS, V111, P237, DOI 10.1542/peds.111.2.237
Dalsgaard S, 2002, BRIT J PSYCHIAT, V181, P416, DOI 10.1192/bjp.181.5.416
Dalsgaard S, 2013, J CHILD ADOL PSYCHOP, V23, P432, DOI 10.1089/cap.2012.0111
DiScala C, 1998, PEDIATRICS, V102, P1415, DOI 10.1542/peds.102.6.1415
FARMER JE, 1995, HEALTH PSYCHOL, V14, P325, DOI 10.1037/0278-6133.14.4.325
Gerring JP, 1998, J AM ACAD CHILD PSY, V37, P647, DOI 10.1097/00004583-199806000-00015
Hodgkins P, 2011, CLIN THER, V33, P188, DOI 10.1016/j.clinthera.2011.03.001
Hurtig T, 2013, J ATTEN DISORD
Kang JH, 2013, ACTA PAEDIATR, V102, P640, DOI 10.1111/apa.12213
Karver CL, 2012, REHABIL PSYCHOL, V57, P256, DOI 10.1037/a0029522
Lang HC, 2010, HEALTH POLICY, V97, P71, DOI 10.1016/j.healthpol.2010.03.005
Lauritsen MB, 2010, J AUTISM DEV DISORD, V40, P139, DOI 10.1007/s10803-009-0818-0
Lee LC, 2008, RES DEV DISABIL, V29, P247, DOI 10.1016/j.ridd.2007.05.002
Levin H, 2007, J DEV BEHAV PEDIATR, V28, P108, DOI 10.1097/01.DBP.0000267559.26576.cd
Linnet KM, 2009, ACTA PAEDIATR, V98, P173, DOI 10.1111/j.1651-2227.2008.00980.x
Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134
Maxson RT, 2009, J PEDIATR SURG, V44, P743, DOI 10.1016/j.jpedsurg.2008.08.003
Merrill RM, 2009, ADV MED SCI-POLAND, V54, P20, DOI 10.2478/v10039-009-0022-7
Miller AR, 2004, AMBUL PEDIATR, V4, P174, DOI 10.1367/A03-031R1.1
Mors O, 2011, SCAND J PUBLIC HEALT, V39, P54, DOI 10.1177/1403494810395825
Nosarti Chiara, 2012, Arch Gen Psychiatry, V69, pE1, DOI 10.1001/archgenpsychiatry.2011.1374
Novik TS, 2006, EUR CHILD ADOLES PSY, V15, P15, DOI 10.1007/s00787-006-1003-z
Pedersen CB, 2006, DAN MED BULL, V53, P441
Pottegard A, 2012, EUR J CLIN PHARMACOL, V68, P1443, DOI 10.1007/s00228-012-1265-y
Research Units on Pediatric Psychopharmacology (RUPP) Autistic Disorder Network, 2005, ARCH GEN PSYCHIAT, V62, P1266
Romano E, 2009, J PEDIATR-US, V155, P721, DOI 10.1016/j.jpeds.2009.05.028
Rowe R, 2004, J PEDIATR PSYCHOL, V29, P119, DOI 10.1093/jpepsy/jsh015
Rucklidge JJ, 2010, PSYCHIAT CLIN N AM, V33, P357, DOI 10.1016/j.psc.2010.01.006
Rucklidge JJ, 2001, J AM ACAD CHILD PSY, V40, P530, DOI 10.1097/00004583-200105000-00012
SAS Institute Inc, 2000, SAS REL 9 2
Schwartz A, 2013, NEW YORK TIMES 0331
Sclar DA, 2012, CLIN PEDIATR, V51, P584, DOI 10.1177/0009922812439621
Stephenson CP, 2013, AUST NZ J PSYCHIAT, V47, P74, DOI 10.1177/0004867412466595
Thapar A, 2012, ARCH DIS CHILD, V97, P260, DOI 10.1136/archdischild-2011-300482
Uslu M, 2007, CLIN ORTHOP RELAT R, P192, DOI 10.1097/BLO.0b013e31805002da
WHO, 1993, ICD 10 CLASS MENT BE
Witwer A, 2005, J CHILD ADOL PSYCHOP, V15, P671, DOI 10.1089/cap.2005.15.671
Xiang HY, 2005, AM J PUBLIC HEALTH, V95, P1970, DOI 10.2105/AJPH.2004.057505
Zetterqvist J, 2013, ACTA PSYCHIAT SCAND, V128, P70, DOI 10.1111/acps.12004
Zito JM, 1999, ARCH PEDIAT ADOL MED, V153, P1257
Zuvekas SH, 2006, AM J PSYCHIAT, V163, P579, DOI 10.1176/appi.ajp.163.4.579
NR 50
TC 1
Z9 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD JUN
PY 2014
VL 24
IS 5
BP 253
EP 259
DI 10.1089/cap.2013.0101
PG 7
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA AJ9EP
UT WOS:000338010400004
PM 24813570
ER
PT J
AU Holmes, KJ
Gathright, MM
Morris, EM
Coffey, B
AF Holmes, Khiela J.
Gathright, Molly M.
Morris, Edwin M.
Coffey, Barbara
TI Psychotic Symptoms and Catatonia in a Preadolescent Boy with Autism
Spectrum Disorder
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID ELECTROCONVULSIVE-THERAPY; SCHIZOPHRENIA; CHILDHOOD; LORAZEPAM; CHILDREN
C1 [Holmes, Khiela J.; Gathright, Molly M.; Morris, Edwin M.] UAMS Coll Med, Inst Psychiat Res, Dept Psychiat, Little Rock, AZ USA.
[Coffey, Barbara] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
RP Coffey, B (reprint author), Icahn Sch Med Mt Sinai, One Gustave L Levy Pl,Box 1230, New York, NY 10029 USA.
EM Barbara.coffey@mssm.edu
FU Eli Lily Pharmaceutical; NIMH; NINDS; Tourette Syndrome Association;
Otsuka; Shire; Bristol-Myers; Pfizer; Boehringer Ingelheim
FX Dr. Holmes, Dr. Gathright, and Mr. Morris have no conflicts of interest
or financial ties to disclose. Dr. Coffey has received research support
from Eli Lily Pharmaceutical, NIMH, NINDS, Tourette Syndrome
Association, Otsuka, Shire, Bristol-Myers, Pfizer, and Boehringer
Ingelheim.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bush G, 1996, ACTA PSYCHIAT SCAND, V93, P137, DOI 10.1111/j.1600-0447.1996.tb09815.x
Cannon M, 2002, ARCH GEN PSYCHIAT, V59, P449, DOI 10.1001/archpsyc.59.5.449
Dhossche DM, 2013, NEUROPSYCHIATRY-LOND, V3, P401, DOI 10.2217/npy.13.42
Dhossche DM, 2009, J ECT, V25, P19, DOI 10.1097/YCT.0b013e3181957363
Green WH., 2007, CHILD ADOLESCENT CLI
Jensen PS, 2007, EUR CHILD ADOLES PSY, V16, P104, DOI 10.1007/s00787-006-0580-1
Konstantareas MM, 2001, J AUTISM DEV DISORD, V31, P19, DOI 10.1023/A:1005605528309
Mejia NI, 2010, EXPERT REV NEUROTHER, V10, P893, DOI [10.1586/ern.10.58, 10.1586/ERN.10.58]
Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63
Seethalakshmi R, 2008, ANN CLIN PSYCHIATRY, V20, P5, DOI 10.1080/10401230701844786
Singh NN, 1989, MASONS DIFFERENTIAL
Sullivan PF, 2012, ARCH GEN PSYCHIAT, V69, P1099, DOI 10.1001/archgenpsychiatry.2012.730
Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
Watt N, 2009, J AUTISM DEV DISORD, V38, P1518
Wing L, 2000, BRIT J PSYCHIAT, V176, P357, DOI 10.1192/bjp.176.4.357
NR 16
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD JUN
PY 2014
VL 24
IS 5
BP 288
EP 292
DI 10.1089/cap.2014.2453
PG 5
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA AJ9EP
UT WOS:000338010400009
PM 24945087
ER
PT J
AU Pearl, PL
Sable, C
Evans, S
Knight, J
Cunningham, P
Lotrecchiano, GR
Gropman, A
Stuart, S
Glass, P
Conway, A
Ramadan, I
Paiva, T
Batshaw, ML
Packer, RJ
AF Pearl, Phillip L.
Sable, Craig
Evans, Sarah
Knight, Joseph
Cunningham, Parker
Lotrecchiano, Gaetano R.
Gropman, Andrea
Stuart, Sheela
Glass, Penny
Conway, Anne
Ramadan, Issam
Paiva, Tania
Batshaw, Mark L.
Packer, Roger J.
TI International Telemedicine Consultations for Neurodevelopmental
Disabilities
SO TELEMEDICINE AND E-HEALTH
LA English
DT Article
DE telemedicine; telehealth; technology; distance learning; education
ID TELEVISION
AB Background: A telemedicine program was developed between the Children's National Medical Center (CNMC) in Washington, DC, and the Sheikh Khalifa Bin Zayed Foundation in the United Arab Emirates (UAE). A needs assessment and a curriculum of on-site training conferences were devised preparatory to an ongoing telemedicine consultation program for children with neurodevelopmental disabilities in the underserved eastern region of the UAE. Materials and Methods: Weekly telemedicine consultations are provided by a multidisciplinary faculty. Patients are presented in the UAE with their therapists and families. Real-time (video over Internet protocol; average connection, 768 kilobits/s) telemedicine conferences are held weekly following previews of medical records. A full consultation report follows each telemedicine session. Results: Between February 29, 2012 and June 26, 2013, 48 weekly 1-h live interactive telemedicine consultations were conducted on 48 patients (28 males, 20 females; age range, 8 months-22 years; median age, 5.4 years). The primary diagnoses were cerebral palsy, neurogenetic disorders, autism, neuromuscular disorders, congenital anomalies, global developmental delay, systemic disease, and epilepsy. Common comorbidities were cognitive impairment, communication disorders, and behavioral disorders. Specific recommendations included imaging and DNA studies, antiseizure management, spasticity management including botulinum toxin protocols, and specific therapy modalities including taping techniques, customized body vests, and speech/language and behavioral therapy. Improved outcomes reported were in clinician satisfaction, achievement of therapy goals for patients, and requests for ongoing sessions. Conclusions: Weekly telemedicine sessions coupled with triannual training conferences were successfully implemented in a clinical program dedicated to patients with neurodevelopmental disabilities by the Center for Neuroscience at CNMC and the UAE government. International consultations in neurodevelopmental disabilities utilizing telemedicine services offer a reliable and productive method for joint clinical programs.
C1 [Pearl, Phillip L.; Evans, Sarah; Knight, Joseph; Cunningham, Parker; Gropman, Andrea; Stuart, Sheela; Glass, Penny; Conway, Anne; Batshaw, Mark L.; Packer, Roger J.] Childrens Natl Med Ctr, Ctr Neurosci & Behav Hlth, Washington, DC 20010 USA.
[Sable, Craig; Ramadan, Issam; Paiva, Tania] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Lotrecchiano, Gaetano R.] George Washington Univ, Sch Med & Hlth Sci, Dept Clin Res & Leadership, Washington, DC 20052 USA.
RP Pearl, PL (reprint author), Harvard Univ, Sch Med, Boston Childrens Hosp, Fegan 9, Boston, MA 02115 USA.
EM Phillip.Pearl@childrens.harvard.edu
FU Sheikh Khalifa bin Zayed Foundation of the United Arab Emirates
government
FX The telemedicine program is supported by the Sheikh Khalifa bin Zayed
Foundation of the United Arab Emirates government.
CR Bar-on ME, 2001, PEDIATRICS, V107, P423
American Telemedicine Association, 2008, COR STAND TEL OP
Bynum AB, 2011, INT J TELEMEDICINE A, V2011
Hancox RJ, 2005, ARCH PEDIAT ADOL MED, V159, P614, DOI 10.1001/archpedi.159.7.614
Kvedar J, 2006, ANN ONCOL, V17, P37, DOI 10.1093/annonc.mdl986
Locatis C, 2012, TELEMED J E-HEALTH, V19, P19
Saliba V, 2012, INT J MED INFORM, V81, P793, DOI 10.1016/j.ijmedinf.2012.08.003
World Health Organization, 2011, GLOB OBS EHEALTH SER, V2
NR 8
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
EI 1556-3669
J9 TELEMED E-HEALTH
JI Telemed. e-Health
PD JUN
PY 2014
VL 20
IS 6
BP 559
EP 562
DI 10.1089/tmj.2013.0275
PG 4
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA AJ8IA
UT WOS:000337945500009
PM 24660879
ER
PT J
AU Qin, MY
Wong, A
Seguin, D
Gerlai, R
AF Qin, Meiying
Wong, Albert
Seguin, Diane
Gerlai, Robert
TI Induction of Social Behavior in Zebrafish: Live Versus Computer Animated
Fish as Stimuli
SO ZEBRAFISH
LA English
DT Article
ID DANIO-RERIO RESPONDS; SHOALING BEHAVIOR; FEAR RESPONSES; IMAGES; MODEL;
NEUROCHEMISTRY; DISORDERS; COGNITION; ETHANOL; AUTISM
AB The zebrafish offers an excellent compromise between system complexity and practical simplicity and has been suggested as a translational research tool for the analysis of human brain disorders associated with abnormalities of social behavior. Unlike laboratory rodents zebrafish are diurnal, thus visual cues may be easily utilized in the analysis of their behavior and brain function. Visual cues, including the sight of conspecifics, have been employed to induce social behavior in zebrafish. However, the method of presentation of these cues and the question of whether computer animated images versus live stimulus fish have differential effects have not been systematically analyzed. Here, we compare the effects of five stimulus presentation types: live conspecifics in the experimental tank or outside the tank, playback of video-recorded live conspecifics, computer animated images of conspecifics presented by two software applications, the previously employed General Fish Animator, and a new application Zebrafish Presenter. We report that all stimuli were equally effective and induced a robust social response (shoaling) manifesting as reduced distance between stimulus and experimental fish. We conclude that presentation of live stimulus fish, or 3D images, is not required and 2D computer animated images are sufficient to induce robust and consistent social behavioral responses in zebrafish.
C1 [Qin, Meiying; Seguin, Diane; Gerlai, Robert] Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada.
[Qin, Meiying; Wong, Albert] Univ Toronto, Dept Comp Sci, Mississauga, ON L5L 1C6, Canada.
[Gerlai, Robert] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada.
RP Gerlai, R (reprint author), Univ Toronto, Dept Psychol, 3359 Mississauga Rd North,Rm DV4023C, Mississauga, ON L5L 1C6, Canada.
EM robert_gerlai@yahoo.com
FU NSERC; NIH/NIAAA
FX This study was supported by an NSERC and an NIH/NIAAA grant to R. G. We
would like to thank Steven Tran, Michele Taffs, James Ng, Yohaan
Fernandes, and Mindy Rampersad for their help. We are also thankful for
Noam Miller who wrote the first version of our GFA software application
several years ago.
CR Abaid N, 2012, BEHAV BRAIN RES, V232, P406, DOI 10.1016/j.bbr.2012.03.028
Ahmed TS, 2012, BEHAVIOUR, V149, P1125, DOI 10.1163/1568539X-00003011
Al-Imari L, 2008, BEHAV BRAIN RES, V189, P216, DOI 10.1016/j.bbr.2007.12.007
Aoki I., 1980, B OCEAN RES I U TOKY, V12, P1
BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
Buske C, 2011, PROG NEURO-PSYCHOPH, V35, P1409, DOI 10.1016/j.pnpbp.2010.09.003
Chen E, 2004, CURR PHARM BIOTECHNO, V5, P409, DOI 10.2174/1389201043376652
Engeszer RE, 2007, ANIM BEHAV, V74, P1269, DOI 10.1016/j.anbehav.2007.01.032
Engeszer RE, 2007, ZEBRAFISH, V4, P21, DOI 10.1089/zeb.2006.9997
Fernandes Y, 2009, ALCOHOL CLIN EXP RES, V33, P601, DOI 10.1111/j.1530-0277.2008.00874.x
Gerlai R, 2009, GENES BRAIN BEHAV, V8, P586, DOI 10.1111/j.1601-183X.2009.00488.x
Gerlai R, 2010, MOLECULES, V15, P2609, DOI 10.3390/molecules15042609
Gerlai R, 2011, REV NEUROSCIENCE, V22, P3, DOI 10.1515/RNS.2011.002
Gerlai R, 2009, BEHAV BRAIN RES, V201, P318, DOI 10.1016/j.bbr.2009.03.003
Gerlai R, 2013, EVOL PSYCHOL, V11, P1
Gerlai Robert, 2012, Curr Top Behav Neurosci, V12, P3, DOI 10.1007/7854_2011_180
Gerlai R, 2000, PHARMACOL BIOCHEM BE, V67, P773, DOI 10.1016/S0091-3057(00)00422-6
Gerlai R, 2008, ALCOHOL CLIN EXP RES, V32, P1763, DOI 10.1111/j.1530-0277.2008.00761.x
Gerlai R, 2010, BEHAV BRAIN RES, V207, P223, DOI 10.1016/j.bbr.2009.10.008
Gomez-Laplaza LM, 2010, BEHAV BRAIN RES, V208, P509, DOI 10.1016/j.bbr.2009.12.031
Hames JL, 2013, ANNU REV CLIN PSYCHO, V9, P355, DOI 10.1146/annurev-clinpsy-050212-185553
Iosifescu DV, 2012, EUR NEUROPSYCHOPHARM, V22, pS499, DOI 10.1016/j.euroneuro.2012.08.002
Kalueff AV, 2013, ZEBRAFISH, V10, P70, DOI 10.1089/zeb.2012.0861
Karnik I, 2012, BEHAV BRAIN RES, V233, P415, DOI 10.1016/j.bbr.2012.05.024
Levin ED, 2007, PHYSIOL BEHAV, V90, P54, DOI 10.1016/j.physbeh.2006.08.026
Luca RM, 2012, BEHAV BRAIN RES, V229, P194, DOI 10.1016/j.bbr.2012.01.021
Luca RM, 2012, BEHAV BRAIN RES, V226, P66, DOI 10.1016/j.bbr.2011.09.001
Miller N, 2007, BEHAV BRAIN RES, V184, P157, DOI 10.1016/j.bbr.2007.07.007
Miller N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048865
Miller N, 2012, BEHAV BRAIN RES, V240, P192
Miller N, 2011, BEHAV RES METHODS, V43, P964, DOI 10.3758/s13428-011-0090-z
Miller NY, 2008, BEHAV BRAIN RES, V193, P148, DOI 10.1016/j.bbr.2008.05.004
Miller NY, 2011, REV NEUROSCIENCE, V22, P17, DOI 10.1515/RNS.2011.004
Neuhauss SCF, 2003, J NEUROBIOL, V54, P148, DOI 10.1002/neu.10165
Pannia E, 2013, BEHAV BRAIN RES, V259, P174
Parra KV, 2009, BEHAV BRAIN RES, V205, P336, DOI 10.1016/j.bbr.2009.06.037
Pather S, 2009, BEHAV BRAIN RES, V196, P323, DOI 10.1016/j.bbr.2008.09.013
Ruhl N, 2005, J FISH BIOL, V67, P1318, DOI 10.1111/j.1095-8649.2005.00826.x
Saif M, 2013, BEHAV BRAIN RES, V243, P294, DOI 10.1016/j.bbr.2013.01.020
Saverino C, 2008, BEHAV BRAIN RES, V191, P77, DOI 10.1016/j.bbr.2008.03.013
Scerbina T, 2012, AMINO ACIDS, V43, P2059, DOI 10.1007/s00726-012-1284-0
Schmidt SJ, 2011, SCHIZOPHRENIA BULL, V37, pS41, DOI 10.1093/schbul/sbr079
Sison M, 2011, NEUROBIOL LEARN MEM, V96, P230, DOI 10.1016/j.nlm.2011.04.016
Sison M, 2006, LAB ANIMAL, V35, P33, DOI 10.1038/laban0506-33
Speedie N, 2008, BEHAV BRAIN RES, V188, P168, DOI 10.1016/j.bbr.2007.10.031
Spence R, 2006, J FISH BIOL, V69, P1435, DOI 10.1111/j.1095-8649.2006.01206.x
Stewart A, 2012, NEUROPHARMACOLOGY, V62, P135, DOI 10.1016/j.neuropharm.2011.07.037
Thoma P, 2013, NEUROSCI BIOBEHAV R, V37, P448, DOI 10.1016/j.neubiorev.2013.01.024
Tran S, 2013, BEHAV BRAIN RES, V252, P204, DOI 10.1016/j.bbr.2013.05.065
Tropepe V, 2003, GENES BRAIN BEHAV, V2, P268, DOI 10.1046/j.1601-183X.2003.00038.x
Turnell ER, 2003, BIOL BULL-US, V205, P225, DOI 10.2307/1543265
NR 51
TC 4
Z9 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1545-8547
EI 1557-8542
J9 ZEBRAFISH
JI Zebrafish
PD JUN
PY 2014
VL 11
IS 3
BP 185
EP 197
DI 10.1089/zeb.2013.0969
PG 13
WC Developmental Biology; Zoology
SC Developmental Biology; Zoology
GA AJ8LZ
UT WOS:000337957400001
PM 24575942
ER
PT J
AU Kamien, B
Lionel, AC
Bain, N
Scherer, SW
Hunter, M
AF Kamien, Benjamin
Lionel, Anath C.
Bain, Nicole
Scherer, Stephen W.
Hunter, Matthew
TI Outfoxed by RBFOX1-A caution about ascertainment bias
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE RBFOX1; A2BP1; FOX1; genetic susceptibility; autism spectrum disorder;
DNA copy number variation; ascertainment bias
ID AUTISM SPECTRUM DISORDERS; GENOME-WIDE ASSOCIATION; COPY NUMBER
VARIATION; MENTAL-RETARDATION; GENE; POPULATION; PHENOTYPE; DELETIONS;
EPILEPSY; COMMON
AB We report on two patients with intragenic deletions of RBFOX1 and one patient with an intragenic duplication of RBFOX1. These patients, by report, all had autism spectrum disorder and/or developmental delay and had strong family histories of these conditions. We initially hypothesized that RBFOX1 was another susceptibility locus for autism spectrum disorder or developmental delay. However, epidemiological evidence examining large numbers of individuals did not support this hypothesis and the data presented here suggests that RBFOX1 intragenic copy number variants are not pathogenic. This contradicts previous reports that examined smaller numbers of patients and controls. (c) 2014 Wiley Periodicals, Inc.
C1 [Kamien, Benjamin; Hunter, Matthew] Hunter Genet, Newcastle, NSW, Australia.
[Kamien, Benjamin; Hunter, Matthew] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW 2300, Australia.
[Lionel, Anath C.; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada.
[Lionel, Anath C.; Scherer, Stephen W.] Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, Canada.
[Lionel, Anath C.; Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
[Lionel, Anath C.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON, Canada.
[Bain, Nicole] Hunter Area Pathol Serv, Dept Mol Med, Newcastle, NSW, Australia.
[Hunter, Matthew] Genet Learning Disabil GOLD Serv, Newcastle, NSW, Australia.
RP Kamien, B (reprint author), Hunter Genet, POB 84, Waratah 2298, Australia.
EM benkamien@yahoo.com.au
RI Scherer, Stephen /B-3785-2013
OI Scherer, Stephen /0000-0002-8326-1999
FU University of Toronto McLaughlin Centre; NeuroDevNet; Genome Canada
Ontario Genomics Institute; Canadian Institutes for Health Research
(CIHR); Canadian Institute for Advanced Research; Canada Foundation for
Innovation; Government of Ontario, Autism Speaks; Hospital for Sick
Children Foundation
FX Grant sponsor: University of Toronto McLaughlin Centre; Grant sponsor:
NeuroDevNet; Grant sponsor: Genome Canada Ontario Genomics Institute;
Grant sponsor: Canadian Institutes for Health Research (CIHR); Grant
sponsor: Canadian Institute for Advanced Research; Grant sponsor: Canada
Foundation for Innovation; Grant sponsor: Government of Ontario, Autism
Speaks; Grant sponsor: Hospital for Sick Children Foundation.
CR Bhalla K, 2004, J HUM GENET, V49, P308, DOI 10.1007/s10038-004-0145-4
Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
Cottrell CE, 2011, AUTISM RES, V4, P189, DOI 10.1002/aur.184
Coviello AD, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002805
Craddock N, 2010, NATURE, V464, P713, DOI 10.1038/nature08979
Davis LK, 2012, AM J MED GENET A, V158A, P1654, DOI 10.1002/ajmg.a.35396
Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
Firth HV, 2009, AM J HUM GENET, V84, P524, DOI 10.1016/j.ajhg.2009.03.010
Heil KM, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-012-0334-3
Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
Altshuler DM, 2010, NATURE, V467, P52, DOI 10.1038/nature09298
Krawczak M, 2006, COMMUNITY GENET, V9, P55, DOI 10.1159/000090694
Lal D, 2013, EPILEPSIA, V54, P265, DOI 10.1111/epi.12084
Martin C, 2007, NATION, V285, P2
Mikhail FM, 2011, AM J MED GENET A, V155A, P2386, DOI 10.1002/ajmg.a.34177
Palmer E, 2011, ARCH DIS CHILD, V96, P473, DOI 10.1136/adc.2009.172825
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Silversides CK, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002843
Stewart AFR, 2009, J AM COLL CARDIOL, V53, P1471, DOI 10.1016/j.jacc.2008.12.051
Zhao WW, 2013, MOL CYTOGENET, V6, DOI 10.1186/1755-8166-6-26
Zogopoulos G, 2007, HUM GENET, V122, P345, DOI 10.1007/s00439-007-0404-5
NR 21
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2014
VL 164
IS 6
BP 1411
EP 1418
DI 10.1002/ajmg.a.36458
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA AH2BV
UT WOS:000335926600007
PM 24664471
ER
PT J
AU Samuels, J
Shugart, YY
Wang, Y
Grados, MA
Bienvenu, OJ
Pinto, A
Rauch, SL
Greenberg, BD
Knowles, JA
Fyer, AJ
Piacentini, J
Pauls, DL
Cullen, B
Rasmussen, SA
Stewart, SE
Geller, DA
Maher, BS
Goes, FS
Murphy, DL
McCracken, JT
Riddle, MA
Nestadt, G
AF Samuels, Jack
Shugart, Yin Yao
Wang, Ying
Grados, Marco A.
Bienvenu, O. Joseph
Pinto, Anthony
Rauch, Scott L.
Greenberg, Benjamin D.
Knowles, James A.
Fyer, Abby J.
Piacentini, John
Pauls, David L.
Cullen, Bernadette
Rasmussen, Steven A.
Stewart, S. Evelyn
Geller, Dan A.
Maher, Brion S.
Goes, Fernando S.
Murphy, Dennis L.
McCracken, James T.
Riddle, Mark A.
Nestadt, Gerald
TI Clinical Correlates and Genetic Linkage of Social and Communication
Difficulties in Families with Obsessive-Compulsive Disorder: Results
From the OCD Collaborative Genetics Study
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE obsessive-compulsive disorder; OCD; pragmatics; genetic linkage
ID BROAD AUTISM PHENOTYPE; PSYCHIATRIC-DISORDERS; ASPERGER-SYNDROME;
CHILDREN; PARENTS; INDIVIDUALS; PERSONALITY; BEHAVIORS; TRAITS; SCAN
AB Some individuals with obsessive-compulsive disorder (OCD) have autistic-like traits, including deficits in social and communication behaviors (pragmatics). The objective of this study was to determine if pragmatic impairment aggregates in OCD families and discriminates a clinically and genetically distinct subtype of OCD. We conducted clinical examinations on, and collected DNA samples from, 706 individuals with OCD in 221 multiply affected OCD families. Using the Pragmatic Rating Scale (PRS), we compared the prevalence of pragmatic impairment in OCD-affected relatives of probands with and without pragmatic impairment. We also compared clinical features of OCD-affected individuals in families having at least one, versus no, individual with pragmatic impairment, and assessed for linkage to OCD in the two groups of families. The odds of pragmatic impairment were substantially greater in OCD-affected relatives of probands with pragmatic impairment. Individuals in high-PRS families had greater odds of separation anxiety disorder and social phobia, and a greater number of schizotypal personality traits. In high-PRS families, there was suggestive linkage to OCD on chromosome 12 at marker D12S1064 and on chromosome X at marker DXS7132 whereas, in low-PRS families, there was suggestive linkage to chromosome 3 at marker D3S2398. Pragmatic impairment aggregates in OCD families. Separation anxiety disorder, social phobia, and schizotypal personality traits are part of a clinical spectrum associated with pragmatic impairment in these families. Specific regions of chromosomes 12 and X are linked to OCD in high-PRS families. Thus, pragmatic impairment may distinguish a clinically and genetically homogeneous subtype of OCD. (C) 2014 Wiley Periodicals, Inc.
C1 [Samuels, Jack; Wang, Ying; Grados, Marco A.; Bienvenu, O. Joseph; Cullen, Bernadette; Goes, Fernando S.; Riddle, Mark A.; Nestadt, Gerald] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
[Shugart, Yin Yao] NIMH, Genom Res Branch, Div Neurosci & Basic Behav Sci, NIH, Bethesda, MD 20892 USA.
[Pinto, Anthony; Fyer, Abby J.] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA.
[Pinto, Anthony; Fyer, Abby J.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Rauch, Scott L.; Geller, Dan A.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Greenberg, Benjamin D.; Rasmussen, Steven A.] Butler Hosp, Brown Med Sch, Dept Psychiat & Human Behav, Providence, RI 02906 USA.
[Knowles, James A.] Univ So Calif, Dept Psychiat, Sch Med, Los Angeles, CA USA.
[Piacentini, John; McCracken, James T.] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
[Pauls, David L.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
[Pauls, David L.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Pauls, David L.] Harvard Univ, Sch Med, Boston, MA USA.
[Stewart, S. Evelyn] Univ British Columbia, Fac Med, Dept Psychiat, Vancouver Fac Med, Vancouver, BC, Canada.
[Maher, Brion S.] Johns Hopkins Univ, Dept Mental Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Murphy, Dennis L.] NIMH, Clin Sci Lab, NIH, Bethesda, MD 20892 USA.
RP Samuels, J (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 550 N Broadway 901, Baltimore, MD 21205 USA.
EM jacks@jhmi.edu
FU National Institutes of Health [R01-MH-50214, R01MH071507, K23-MH-64543,
NIH/NCRR/OPD-GCRC RR00052]; James E. Marshall OCD Foundation
FX Grant sponsor: National Institutes of Health; Grant numbers:
R01-MH-50214, R01MH071507, K23-MH-64543, NIH/NCRR/OPD-GCRC RR00052;
Grant sponsor: James E. Marshall OCD Foundation.
CR Abecasis GR, 2002, NAT GENET, V30, P97, DOI 10.1038/ng786
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anholt GE, 2010, J AUTISM DEV DISORD, V40, P580, DOI 10.1007/s10803-009-0922-1
Bara BG, 1999, BRAIN LANG, V68, P507, DOI 10.1006/brln.1999.2125
Bejerot A, 2001, NORD J PSYCHIAT, V55, P169
Bejerot S, 2007, AUTISM, V11, P101, DOI 10.1177/1362361307075699
Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
Broman KW, 1998, AM J HUM GENET, V63, P259
Brune CW, 2008, AUTISM RES, V1, P108, DOI 10.1002/aur.11
Buxbaum JD, 2004, MOL PSYCHIATR, V9, P144, DOI 10.1038/sj.mp.4001465
Caamano M, 2013, J AUTISM DEV DISORD, V43, P2442, DOI 10.1007/s10803-013-1792-0
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Cullen B, 2008, PSYCHOPATHOLOGY, V41, P194, DOI 10.1159/000120988
Delorme R, 2010, BMC MED GENET, V11, P1
Douglas JA, 2002, AM J HUM GENET, V70, P487, DOI 10.1086/338919
First M. B., 1996, STRUCTURED CLIN INTE
FOLSTEIN SE, 1988, J AUTISM DEV DISORD, V18, P3, DOI 10.1007/BF02211815
Fyer AJ, 1990, SCHEDULE AFFECTIVE D
GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
Hollander E, 2003, PSYCHIAT RES, V117, P11, DOI 10.1016/S0165-1781(02)00304-9
Ivarsson T, 2008, J ANXIETY DISORD, V22, P969, DOI 10.1016/j.janxdis.2007.10.003
Kantojarvi K, 2010, PSYCHIAT GENET, V20, P102, DOI 10.1097/YPG.0b013e32833a2080
Kong A, 1997, AM J HUM GENET, V61, P1179, DOI 10.1086/301592
LANDA R, 1992, PSYCHOL MED, V22, P245
LANDER E, 1995, NAT GENET, V11, P241, DOI 10.1038/ng1195-241
Lewin AB, 2011, J DEV PHYS DISABIL, V23, P543, DOI 10.1007/s10882-011-9247-z
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x
Mannuzza S, 1985, FAMILY INFORM SCHEDU
MANNUZZA S, 1986, J PSYCHIAT RES, V20, P317, DOI 10.1016/0022-3956(86)90034-8
MCDOUGLE CJ, 1995, AM J PSYCHIAT, V152, P772
Micali N, 2004, AUTISM, V8, P21, DOI 10.1177/1362361304040636
Miguel EC, 2005, MOL PSYCHIATR, V10, P258, DOI 10.1038/sj.mp.4001617
Murphy DL, 2013, PHILOS T R SOC B, V368, DOI 10.1098/rstb.2012.0435
Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949
O'Connell JR, 1998, AM J HUM GENET, V63, P259, DOI 10.1086/301904
Pauls DL, 2008, AM J MED GENET C, V148C, P133, DOI 10.1002/ajmg.c.30168
Pfohl B, 1995, STRUCTURED INTERVIEW
Pickles A, 2000, J CHILD PSYCHOL PSYC, V41, P491, DOI 10.1017/S0021963099005557
Piven J, 1999, AM J PSYCHIAT, V156, P557
PIVEN J, 1994, PSYCHOL MED, V24, P783
Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D
PIVEN J, 1990, J AM ACAD CHILD PSY, V29, P177, DOI 10.1097/00004583-199003000-00004
Pulver AE, 2000, MOL PSYCHIATR, V5, P650, DOI 10.1038/sj.mp.4000814
RASMUSSEN SA, 1988, PSYCHOPHARMACOL BULL, V24, P466
Ruser TF, 2007, J AUTISM DEV DISORD, V37, P1323, DOI 10.1007/s10803-006-0274-z
Russell AJ, 2005, BRIT J PSYCHIAT, V186, P525, DOI 10.1192/bjp.186.6.525
Ruta L, 2010, EUR CHILD ADOLES PSY, V19, P17, DOI 10.1007/s00787-009-0035-6
Samuels J, 2007, AM J PSYCHIAT, V164, P493, DOI 10.1176/appi.ajp.164.3.493
Samuels JF, 2006, AM J MED GENET B, V141B, P201, DOI 10.1002/ajmg.b.30224
Shugart YY, 2006, MOL PSYCHIATR, V11, P763, DOI 10.1038/sj.mp.4001847
Smalley SL, 1994, AM J MED GENET B, V54B, P1
Smith CJ, 2009, J CHILD PSYCHOL PSYC, V50, P982, DOI 10.1111/j.1469-7610.2009.02060.x
Szatmari P, 1998, J AUTISM DEV DISORD, V28, P351, DOI 10.1023/A:1026096203946
Willour VL, 2004, AM J HUM GENET, V75, P508, DOI 10.1086/423899
Ylisaukko-oja T, 2004, MOL PSYCHIATR, V9, P161, DOI 10.1038/sj.mp.4001385
ZEGER SL, 1986, BIOMETRICS, V42, P121, DOI 10.2307/2531248
NR 57
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUN
PY 2014
VL 165
IS 4
BP 326
EP 336
DI 10.1002/ajmg.b.32235
PG 11
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA AJ4UX
UT WOS:000337674600006
PM 24798771
ER
PT J
AU Costain, G
Lionel, AC
Fu, F
Stavropoulos, DJ
Gazzellone, MJ
Marshall, CR
Scherer, SW
Bassett, AS
AF Costain, Gregory
Lionel, Anath C.
Fu, Fiona
Stavropoulos, Dimitri J.
Gazzellone, Matthew J.
Marshall, Christian R.
Scherer, Stephen W.
Bassett, Anne S.
TI Adult Neuropsychiatric Expression and Familial Segregation of 2q13
Duplications
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE chromosome 2q13; copy number variation; schizophrenia;
obsessive-compulsive; genomic disorder; genetic counseling; GABA;
SLC1A1; RHOA; microRNA; chromosome 16p13.11
ID COPY NUMBER VARIANTS; CHROMOSOMAL MICROARRAY; DEVELOPMENTAL DELAY;
SCHIZOPHRENIA; DISORDER; REARRANGEMENTS; GENES; RISK
AB New genomic disorders associated with large, rare, recurrent copy number variations (CNVs) are being discovered at a rapid pace. Detailed phenotyping and family studies are rare, however, as are data on adult phenotypic expression. Duplications at 2q13 were recently identified as risk factors for developmental delay/autism and reported in the prenatal setting, yet few individuals (all children) have been extensively phenotyped. During a genome-wide CNV study of schizophrenia, we identified two unrelated probands with 2q13 duplications. In this study, detailed phenotyping and genotyping using high-resolution microarrays was performed for 12 individuals across their two families. 2q13 duplications were present in six adults, and co-segregated with clinically significant later-onset neuropsychiatric disorders. Convergent lines of evidence implicated GABAminergic dysfunction. Analysis of the genic content revealed promising candidates for neuropsychiatric disease, including BCL2L11, ANAPC1, and MERTK. Intrafamilial genetic heterogeneity and "second hits" in one family may have been the consequence of assortative mating. Clinical genetic testing for the 2q13 duplication and the associated genetic counseling was well received. In summary, large rare 2q13 duplications appear to be associated with variable adult neuropsychiatric and other expression. The findings represent progress toward clinical translation of research results in schizophrenia. There are implications for other emerging genomic disorders where there is interest in lifelong expression. (C) 2014 Wiley Periodicals, Inc.
C1 [Costain, Gregory; Fu, Fiona; Bassett, Anne S.] Ctr Addict & Mental Hlth, Clin Genet Res Program, Toronto, ON M5S 2S1, Canada.
[Lionel, Anath C.; Gazzellone, Matthew J.; Marshall, Christian R.; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada.
[Lionel, Anath C.; Gazzellone, Matthew J.; Marshall, Christian R.; Scherer, Stephen W.] Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, Canada.
[Lionel, Anath C.; Gazzellone, Matthew J.; Marshall, Christian R.; Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
[Lionel, Anath C.; Gazzellone, Matthew J.; Marshall, Christian R.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON, Canada.
[Stavropoulos, Dimitri J.] Hosp Sick Children, Dept Pediat Lab Med, Cytogenet Lab, Toronto, ON M5G 1X8, Canada.
[Stavropoulos, Dimitri J.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
[Bassett, Anne S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
[Bassett, Anne S.] Univ Hlth Network, Dept Psychiat, Toronto, ON, Canada.
[Bassett, Anne S.] Univ Hlth Network, Dept Med, Div Cardiol, Toronto, ON, Canada.
RP Bassett, AS (reprint author), Ctr Addict & Mental Hlth, 33 Russell St,Room 1100, Toronto, ON M5S 2S1, Canada.
EM anne.bassett@utoronto.ca
RI Scherer, Stephen /B-3785-2013
OI Scherer, Stephen /0000-0002-8326-1999
FU Canadian Institutes of Health Research (CIHR) [MOP-89066, MOP-111238];
McLaughlin Centre Accelerator Grant
FX Grant sponsor: Canadian Institutes of Health Research (CIHR), Grant
numbers: MOP-89066, MOP-111238; Grant sponsor: McLaughlin Centre
Accelerator Grant.
CR Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Costain G, 2011, J MED GENET, V48, P819, DOI 10.1136/jmedgenet-2011-100440
Costain G, 2014, SCHIZOPHRENIA BULL, V40, P88, DOI 10.1093/schbul/sbs124
Costain G, 2013, HUM MOL GENET, V22, P4485, DOI 10.1093/hmg/ddt297
Costain G, 2014, SCHIZOPHRENIA BULL, V40, P78, DOI 10.1093/schbul/sbs138
Costain G, 2015, EUR J HUM GENET, V23, P4, DOI 10.1038/ejhg.2014.64
Dick DM, 2010, AM J MED GENET B, V153B, P1179, DOI 10.1002/ajmg.b.31089
Dolcetti A, 2013, GENET MED, V15, P282, DOI 10.1038/gim.2012.129
Flessner CA, 2012, PSYCHIAT RES, V199, P151, DOI 10.1016/j.psychres.2012.03.039
Glass IA, 1998, J MED GENET, V35, P319, DOI 10.1136/jmg.35.4.319
Hines RM, 2012, CURR OPIN NEUROBIOL, V22, P552, DOI 10.1016/j.conb.2011.10.007
Kearney HM, 2011, GENET MED, V13, P680, DOI 10.1097/GIM.0b013e3182217a3a
Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
Lewis CM, 2003, AM J HUM GENET, V73, P34, DOI 10.1086/376549
Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Myles-Worsley M, 2013, AM J MED GENET B, V162B, P87, DOI 10.1002/ajmg.b.32125
Nelson EC, 2004, ARCH GEN PSYCHIAT, V61, P257, DOI 10.1001/archpsyc.61.3.257
Nishiike S, 2001, ACTA OTO-LARYNGOL, P61
PERRY TL, 1983, BIOL PSYCHIAT, V18, P89
Pietilainen OPH, 2011, HUM MOL GENET, V20, P2686, DOI 10.1093/hmg/ddr162
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Rudd MK, 2009, HUM MOL GENET, V18, P2957, DOI 10.1093/hmg/ddp233
Silversides CK, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002843
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Tropeano M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061365
Wapner RJ, 2012, NEW ENGL J MED, V367, P2175, DOI 10.1056/NEJMoa1203382
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
Yu HE, 2012, CLIN GENET, V81, P257, DOI 10.1111/j.1399-0004.2011.01637.x
NR 30
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUN
PY 2014
VL 165
IS 4
BP 337
EP 344
DI 10.1002/ajmg.b.32236
PG 8
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA AJ4UX
UT WOS:000337674600007
PM 24807792
ER
PT J
AU Mirzaa, GM
Poduri, A
AF Mirzaa, Ghayda M.
Poduri, Annapurna
TI Megalencephaly and hemimegalencephaly: Breakthroughs in molecular
etiology
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
LA English
DT Article
DE megalencephaly; hemimegalencephaly; polymicrogyria; somatic mosaicism;
overgrowth; PI3K-AKT-mTOR pathway; Ras; MAPK pathway
ID AUTISM SPECTRUM DISORDERS; MARMORATA TELANGIECTATICA CONGENITA;
RILEY-RUVALCABA-SYNDROME; ACTIVATING MUTATIONS; CUTIS MARMORATA; PTEN
GENE; CYCLIN D2; BEHAVIORAL ABNORMALITIES; CAPILLARY MALFORMATION;
GERMLINE MUTATIONS
AB Megalencephaly (MEG) is a developmental disorder characterized by brain overgrowth that occurs due to either increased number or size of neurons and glial cells. The former may be due to either increased neuronal proliferation or decreased apoptosis. The degree of brain overgrowth may be extensive, ranging from generalized MEG affecting the entire cortex-as with mutations in PTEN (phosphatase and tensin homolog on chromosome ten)-to unilateral hemispheric malformations-as in classic hemimegalencephaly (HME). On the other hand, some lesions are more focal or segmental. These developmental brain abnormalities may occur in isolation in some individuals, whereas others occur in the context of a syndrome involving dysmorphic features, skin findings, or other organ system involvement. Brain overgrowth disorders are often associated with malformations of cortical development, resulting in increased risk of epilepsy, intellectual disability, and autistic features, and some are associated with hydrocephalus. The past few years have witnessed a dramatic leap in our understanding of the molecular basis of brain overgrowth, particularly the identification of mosaic (or post-zygotic) mutations in core components of key cellular pathways such as the phosphatidylinositol 3-kinase (PI3K)-vakt murine thymoma viral oncogene homolog (AKT)-mTOR pathway. These molecular insights have broadened our view of brain overgrowth disorders that now appear to span a wide spectrum of overlapping phenotypic, neuroimaging, and neuropathologic features and molecular pathogenesis. These molecular advances also bring to light the possibility of pathway-based therapies for these often medically devastating developmental disorders. (c) 2014 Wiley Periodicals, Inc.
C1 [Mirzaa, Ghayda M.] Seattle Childrens Hosp, Dept Human Genet, Seattle, WA USA.
[Mirzaa, Ghayda M.] Seattle Childrens Res Inst, Seattle, WA USA.
[Poduri, Annapurna] Boston Childrens Hosp, Div Epilepsy & Clin Electrophysiol, Dept Neurol, Hosp Epilepsy Genet Program, Boston, MA USA.
[Poduri, Annapurna] NINDS, Supported Ctr, Bethesda, MD 20892 USA.
RP Mirzaa, GM (reprint author), Univ Washington, Div Med Genet, Dept Pediat, Ctr Integrat Brain Res,Seattle Childrens Res Inst, 1900 9th Ave, Seattle, WA 98101 USA.
EM gmirzaa@uw.edu; annapurna.poduri@childrens.harvard.edu
FU NINDS [NS069784]
FX The authors thank our patients and their families for their valuable and
ongoing contributions and support of our research. A. P. was supported
by the NINDS (NS069784).
CR AALFS CM, 1995, J MED GENET, V32, P968, DOI 10.1136/jmg.32.12.968
Marsh DJ, 1997, NAT GENET, V16, P333, DOI 10.1038/ng0897-333
Ballif BC, 2012, HUM GENET, V131, P145, DOI 10.1007/s00439-011-1073-y
BARKOVICH AJ, 1991, ANN NEUROL, V30, P139, DOI 10.1002/ana.410300204
Blumcke I, 2011, CLIN NEUROPATHOL, V30, P164, DOI 10.5414/NP300398
Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493
Chung BK, 2014, AM J MED GENET A, V9999, P1
ClaytonSmith J, 1997, CLIN DYSMORPHOL, V6, P291, DOI 10.1097/00019605-199710000-00001
Conway RL, 2007, J NEUROSURG, V106, P296, DOI 10.3171/ped.2007.106.4.296
Conway RL, 2007, AM J MED GENET A, V143A, P2981, DOI 10.1002/ajmg.a.32040
Crino Peter B, 2007, Novartis Found Symp, V288, P260
Crino PB, 2007, NOVART FDN SYMP, V288, P272
Crino PB, 2010, NEUROLOGY, V74, P1716, DOI 10.1212/WNL.0b013e3181e04325
CRISTALDI A, 1995, EUR J PEDIATR, V154, P134
DEMYER W, 1972, NEUROLOGY, V22, P634
DeMyer W, 1986, Pediatr Neurol, V2, P321, DOI 10.1016/0887-8994(86)90072-X
Elia M, 2012, BRAIN DEV-JPN, V34, P873, DOI 10.1016/j.braindev.2012.03.005
Glickstein SB, 2007, CEREB CORTEX, V17, P632, DOI 10.1093/cercor/bhk008
Glickstein SB, 2009, J NEUROSCI, V29, P9614, DOI 10.1523/JNEUROSCI.2284-09.2009
GORLIN RJ, 1992, AM J MED GENET, V44, P307, DOI 10.1002/ajmg.1320440309
Hobert JA, 2014, EUR J HUM GENET, V22, P273, DOI 10.1038/ejhg.2013.114
INABA T, 1992, GENOMICS, V13, P565, DOI 10.1016/0888-7543(92)90126-D
Kariminejad A, 2012, J CHILD NEUROL, V28, P651
Kida A, 2007, ONCOGENE, V26, P6630, DOI 10.1038/sj.onc.1210490
Kingwell Katie, 2013, Nat Rev Neurol, V9, P6, DOI 10.1038/nrneurol.2012.257
Krueger DA, 2013, ANN NEUROL, V74, P679, DOI 10.1002/ana.23960
Kurek KC, 2012, AM J HUM GENET, V90, P1108, DOI 10.1016/j.ajhg.2012.05.006
Kwon CH, 2003, P NATL ACAD SCI USA, V100, P12923, DOI 10.1073/pnas.2132711100
Kwon CH, 2001, NAT GENET, V29, P404, DOI 10.1038/ng781
Lee JH, 2012, NAT GENET, V44, P941, DOI 10.1038/ng.2329
Liaw D, 1997, NAT GENET, V16, P64, DOI 10.1038/ng0597-64
Lim KC, 2013, NEUROSCIENCE, V252, P262, DOI 10.1016/j.neuroscience.2013.07.037
Lindhurst MJ, 2011, NEW ENGL J MED, V365, P611, DOI 10.1056/NEJMoa1104017
Lindhurst MJ, 2012, NAT GENET, V44, P928, DOI 10.1038/ng.2332
Malan V, 2010, EUR J HUM GENET, V18, P227, DOI 10.1038/ejhg.2009.162
Marsh DJ, 1999, HUM MOL GENET, V8, P1461, DOI 10.1093/hmg/8.8.1461
MATSUSHIME H, 1991, CELL, V65, P701, DOI 10.1016/0092-8674(91)90101-4
Merks JHM, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.10.e111
Mirzaa GM, 2014, NAT GENET, V46, P510, DOI 10.1038/ng.2948
Mirzaa GM, 2012, SWAIMANS PEDIAT NEUR, V2, P173
Mirzaa GM, 2012, AM J MED GENET A, V158A, P269, DOI 10.1002/ajmg.a.34402
Mirzaa GM, 2013, AM J MED GENET C, V163C, P122, DOI 10.1002/ajmg.c.31361
Moore CA, 1997, AM J MED GENET, V70, P67, DOI 10.1002/(SICI)1096-8628(19970502)70:1<67::AID-AJMG13>3.3.CO;2-4
Nakahashi M, 2009, NEURORADIOLOGY, V51, P821, DOI 10.1007/s00234-009-0579-7
Nakamura K, 2014, CLIN GENET, V85, P396, DOI 10.1111/cge.12188
Ogawa S, 2007, BRAIN RES, V1168, P112, DOI 10.1016/j.brainres.2007.06.074
Pavlidis E, 2012, EUR J PAEDIATR NEURO, V16, P332, DOI 10.1016/j.ejpn.2011.12.004
Poduri A, 2013, SCIENCE, V341, P43, DOI 10.1126/science.1237758
Poduri A, 2012, NEURON, V74, P41, DOI 10.1016/j.neuron.2012.03.010
Rios JJ, 2013, HUM MOL GENET, V22, P444, DOI 10.1093/hmg/dds440
Riviere JB, 2012, NAT GENET, V44, P934, DOI 10.1038/ng.2331
Rosenfeld J A, 2013, Mol Syndromol, V3, P247, DOI 10.1159/000345578
Ross ME, 1996, J NEUROSCI, V16, P210
Samuels Yardena, 2010, Curr Top Microbiol Immunol, V347, P21, DOI 10.1007/82_2010_68
Samuels Y, 2006, CURR OPIN ONCOL, V18, P77, DOI 10.1097/01.cco.0000198021.99347.b9
Sato N, 2007, AM J NEURORADIOL, V28, P678
Sharma Suvasini, 2009, Dermatol Online J, V15, P12
Shinawi M, 2009, J MED GENET, V47, P332
Shiroishi MS, 2010, PEDIATR RADIOL, V40, P1826, DOI 10.1007/s00247-010-1624-8
Tan MH, 2011, AM J HUM GENET, V88, P42, DOI 10.1016/j.ajhg.2010.11.013
Tatton-Brown K, 2005, AM J HUM GENET, V77, P193, DOI 10.1086/432082
van Bokhoven H, 2005, NAT GENET, V37, P465, DOI 10.1038/ng1546
van Bon BWM, 2011, EUR J HUM GENET, V19, P400, DOI 10.1038/ejhg.2010.211
Wang D, 2013, AM J MED GENET A, V161, P2016, DOI 10.1002/ajmg.a.35999
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
NR 67
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4868
EI 1552-4876
J9 AM J MED GENET C
JI Am. J. Med. Genet. C
PD JUN
PY 2014
VL 166
IS 2
SI SI
BP 156
EP 172
DI 10.1002/ajmg.c.31401
PG 17
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ4HF
UT WOS:000337633800004
PM 24888963
ER
PT J
AU Palmer, EE
Mowat, D
AF Palmer, Elizabeth Emma
Mowat, David
TI Agenesis of the corpus callosum: A clinical approach to diagnosis
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
LA English
DT Article
DE agenesis of the corpus callosum; prenatal; postnatal; review; genetics;
clinical; genetic counseling
ID INTELLECTUAL DISABILITY; MENTAL-RETARDATION; CHILDREN; POPULATION;
DYSGENESIS; MICROARRAY; C12ORF57; AUTISM
AB This review article aims to guide the clinician in establishing a diagnosis in patients with agenesis of the corpus callosum (ACC), presenting antenatally or postnatally. ACC may be isolated, or occur in association with other neuroanatomical lesions and/or congenital anomalies, and has many different genetic causes. Neuropsychological outcome varies considerably from normal to profound intellectual disability depending on the etiology. Approximately 25% of individuals with antenatally diagnosed apparently isolated ACC have intellectual disability. Subtle neurological, social, and learning deficits may still occur in those with normal intelligence and longitudinal neurocognitive follow-up is recommended for all children with ACC. The finding of ACC should prompt detailed clinical assessment in order to determine and manage the underlying condition. It is recognized that genetic factors contribute to ACC in the vast majority of cases. Less commonly ACC can result from antenatal infections, vascular or toxic insults, and it is increasingly recognized that ACC, particularly isolated ACC, may be due to an interaction of a number of modifier genetic and environmental factors. There are a large number of genetic conditions in which ACC may be a feature. We suggest a diagnostic algorithm to help guide the clinician towards diagnosis, to provide outcome advice and to aid in genetic counseling. (c) 2014 Wiley Periodicals, Inc.
C1 [Palmer, Elizabeth Emma] Genet Learning Disabil GOLD Serv, Sydney, NSW, Australia.
RP Palmer, EE (reprint author), Sydney Childrens Hosp, Dept Med Genet, High St, Randwick, NSW, Australia.
EM elizabeth.palmer@sesiahs.health.nsw.gov.au
CR Aboitiz F, 2003, BRAZ J MED BIOL RES, V36, P409, DOI 10.1590/S0100-879X2003000400002
Akizu N, 2013, AM J HUM GENET, V92, P392, DOI 10.1016/j.ajhg.2013.02.004
Badaruddin DH, 2007, CHILD PSYCHIAT HUM D, V38, P287, DOI 10.1007/s10578-007-0065-6
Bedeschi MF, 2006, PEDIATR NEUROL, V34, P186, DOI 10.1016/j.pediatrneurol.2005.08.008
Bennett GL, 1996, RADIOLOGY, V199, P447
Bloom JS, 2005, NEUROPSYCHOL REV, V15, P59, DOI 10.1007/s11065-005-6252-y
de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
Dobyns WB, 1996, AM J HUM GENET, V58, P7
Edwards TJ, 2014, BRAIN, V137, P1579, DOI 10.1093/brain/awt358
Frazier TW, 2009, BIOL PSYCHIAT, V66, P935, DOI 10.1016/j.biopsych.2009.07.022
Glass HC, 2008, AM J MED GENET A, V146A, P2495, DOI 10.1002/ajmg.a.32418
GROGONO JL, 1968, DEV MED CHILD NEUROL, V10, P613
Hinkley LBN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039804
JERET JS, 1986, PEDIATR NEUROSCI, V12, P101
Lau YC, 2013, J AUTISM DEV DISORD, V43, P1106, DOI 10.1007/s10803-012-1653-2
Moutard ML, 2012, PRENATAL DIAG, V32, P277, DOI 10.1002/pd.3824
O'Driscoll MC, 2010, AM J MED GENET A, V152A, P2145, DOI 10.1002/ajmg.a.33558
Palmer E, 2014, AM J MED GENET A, V164, P377, DOI 10.1002/ajmg.a.36279
Palmer EE, 2012, J PAEDIATR CHILD H, V48, pE59, DOI 10.1111/j.1440-1754.2011.02081.x
Paul LK, 2007, NAT REV NEUROSCI, V8, P287, DOI 10.1038/nrn2107
Paul LK, 2011, J NEURODEV DISORD, V3, P3, DOI 10.1007/s11689-010-9059-y
Sajan SA, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003823
Salih MA, 2013, AM J MED GENET A, V161A, P1207, DOI 10.1002/ajmg.a.35850
Santo S, 2012, ULTRASOUND OBST GYN, V40, P513, DOI 10.1002/uog.12315
SCHAEFER GB, 1992, PEDIATR CLIN N AM, V39, P929
Schell-Apacik CC, 2008, AM J MED GENET A, V146A, P2501, DOI 10.1002/ajmg.a.32476
Siffredi V, 2013, DEV NEUROPSYCHOL, V38, P36, DOI 10.1080/87565641.2012.721421
Sotiriadis A, 2012, AM J OBSTET GYNECOL, V206
Temtamy SA, 1996, CLIN DYSMORPHOL, V5, P231
Tovar-Moll F, 2007, CEREB CORTEX, V17, P531, DOI 10.1093/cercor/bhj178
Volpe P, 2006, ULTRASOUND OBST GYN, V27, P509, DOI 10.1002/uog.2774
WITELSON SF, 1989, BRAIN, V112, P799, DOI 10.1093/brain/112.3.799
Young ID., 1995, FETAL NEONATAL NEURO, P256
Zahrani F, 2013, AM J HUM GENET, V92, P387, DOI 10.1016/j.ajhg.2013.01.008
NR 34
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4868
EI 1552-4876
J9 AM J MED GENET C
JI Am. J. Med. Genet. C
PD JUN
PY 2014
VL 166
IS 2
SI SI
BP 184
EP 197
DI 10.1002/ajmg.c.31405
PG 14
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ4HF
UT WOS:000337633800006
PM 24866859
ER
PT J
AU King, AM
Thomeczek, M
Voreis, G
Scott, V
AF King, Amie M.
Thomeczek, Melissa
Voreis, Grayce
Scott, Victoria
TI iPad (R) use in children and young adults with Autism Spectrum Disorder:
An observational study
SO CHILD LANGUAGE TEACHING & THERAPY
LA English
DT Article
DE Augmentative and alternative communication (AAC); autism spectrum
disorders (ASDs); digital technology; iPad (R); schools
ID ACADEMIC SKILLS; STUDENTS; INDIVIDUALS
AB This exploratory study was conducted to describe how children and young adults with autism spectrum disorder (ASD) are currently using iPads (R) and applications, to explore the role of education professionals on iPad (R) and application use, and to determine potential research needs regarding iPad (R) use in children with ASD. Naturalistic observations were conducted on six individuals (ages 6;6 to 20;8) with ASD while they were using iPads (R) in their school environment. The data suggest that (1) the participants used iPads (R) and applications for a variety of purposes, (2) there was considerable variability regarding whether or not the application was used consistent with its intended function, and (3) the presence of an education professional and the type of application impacted the variability in functional use of the application. Pertinent lines of research that are needed to expand the base of evidence regarding effective iPad (R) use in children with ASD are discussed.
C1 [King, Amie M.; Voreis, Grayce; Scott, Victoria] So Illinois Univ, Dept Special Educ & Commun Disorders, Edwardsville, IL 62232 USA.
[Thomeczek, Melissa] So Illinois Univ, Dept Educ Leadership, Edwardsville, IL 62232 USA.
RP King, AM (reprint author), So Illinois Univ, Dept Special Educ & Commun Disorders, 1147 Founders Hall, Edwardsville, IL 62232 USA.
EM aking@siue.edu
CR Blischak DM, 2001, FOCUS AUTISM OTHER D, V16, P170, DOI 10.1177/108835760101600305
Burton CE, 2013, FOCUS AUTISM DEV DIS, V28, P67, DOI 10.1177/1088357613478829
Centers for Disease Control and Prevention, 2012, PREVALENCE OF AUTISM
Dodge J, 2013, EVALUATING PICTURE E, DOI 10.007/s10882-013-9337-1
Doonan Speech Therapy, 2011, SPEECH WITH MILO SEQ
Google, 2013, GOOGLE SCHOLAR
Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
Johnson JM, 2006, AUGMENT ALTERN COMM, V22, P85, DOI 10.1080/07434610500483588
Kagohara DM, 2012, RES AUTISM SPECT DIS, V6, P304, DOI 10.1016/j.rasd.2011.05.012
Kagohara DM, 2013, RES DEV DISABIL, V34, P147, DOI 10.1016/j.ridd.2012.07.027
Kindergarten.com, 2011, ABA FLASH CARDS ANIM
Knight V, 2013, J AUTISM DEV DISORD, V43, P2628, DOI 10.1007/s10803-013-1814-y
Noldus Information Technology, 2013, NOLDUS OBSERVER XT V
Marvin LA, 2003, CONT ISSUES COMMUNIC, V30, P76
Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081
McNaughton D, 2013, AUGMENT ALTERN COMM, V29, P107, DOI 10.3109/07434618.2013.784930
Mellman LM, 2010, PERSPECTIVES ON AUGM, V19, P108, DOI 10.1044/aac19.4.108
More CM, 2012, YOUNG EXCEPTIONAL CH, V16, P15
Murdock LC, 2013, J AUTISM DEV DISORD, V43, P2174, DOI 10.1007/s10803-013-1770-6
National Autism Center, 2009, THE NATIONAL STANDAR
Neely L, 2013, RES AUTISM SPECT DIS, V7, P509, DOI 10.1016/j.rasd.2012.12.004
Pennington RC, 2010, FOCUS AUTISM DEV DIS, V25, P239, DOI 10.1177/1088357610378291
Pinger, 2011, DOODLE BUDDY VERSION
Priest N, 2001, AUSTR OCCUPATIONAL T, V48, P11, DOI 10.1046/j.1440-1630.2001.00220.x
Ramdoss S., 2011, J BEHAV ED, V20, P55, DOI 10.1007/s10864-010-9112-7
Schlosser RW, 2009, AUTISM SPECTRUM DISO, P141
Shane HC, 2008, J AUTISM DEV DISORD, V38, P1499, DOI 10.1007/s10803-007-0527-5
Simpson RL, 2005, FOCUS AUTISM OTHER D, V20, P140, DOI 10.1177/10883576050200030201
Soto G, 1997, AUGMENTATIVE ALTERNA, V13, P186, DOI DOI 10.1080/07434619712331278008
Tincani M, 2005, HANDBOOK OF SPECIAL, P413
Walker H, 2011, J SPECIAL ED TECHNOL, V26, P59
WETHERBY AM, 1992, J SPEECH HEAR RES, V35, P130
Wizard Talking, 2011, SPLINGOS LANGUAGE UN
NR 33
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0265-6590
EI 1477-0865
J9 CHILD LANG TEACH THE
JI Child Lang. Teach. Ther.
PD JUN
PY 2014
VL 30
IS 2
BP 159
EP 173
DI 10.1177/0265659013510922
PG 15
WC Education, Special; Linguistics; Language & Linguistics
SC Education & Educational Research; Linguistics
GA AJ3EQ
UT WOS:000337549700003
ER
PT J
AU Kimple, KS
Bartelt, EA
Wysocki, KL
Steiner, MJ
AF Kimple, Kelly S.
Bartelt, Erica A.
Wysocki, Karen L.
Steiner, Michael J.
TI Performance of the Modified Checklist for Autism in Toddlers in
Spanish-Speaking Patients
SO CLINICAL PEDIATRICS
LA English
DT Article
DE autism; screening; Modified Checklist for Autism in Toddlers (M-CHAT);
Spanish; Latino
ID PERVASIVE DEVELOPMENTAL DISORDERS; NON-HISPANIC WHITE; SPECTRUM
DISORDERS; CHILDRENS-HEALTH; NATIONAL-SURVEY; PRIMARY-CARE; RISK;
IDENTIFICATION; PREVALENCE; COMMUNITY
AB Objective. To compare abnormal screening rates of 2 different Spanish versions of the Modified Checklist for Autism in Toddlers (M-CHAT) in US Spanish-speaking patients. Method. Quasi-experimental design was used with historical and English language controls. Abnormal screening rates were compared between Spain and Western-hemisphere Spanish versions, as well as to English controls during the same time periods using chi square analysis. Results. M-CHAT questionnaires were scored from 589 subjects (English n = 415, Spanish n = 174). There was little difference between Spanish versions. Overall, the Spanish abnormal screening rate was double that of English (23.6% vs 11.3%, P < .001). Conclusions. Spanish M-CHAT questionnaires are abnormal more often than those in English even after changing to appropriate translation, despite lower prevalence of autism in Latinos. Issues with translation, interpretation, or cultural understanding of behaviors may contribute. Given abnormal screening rates for Latinos, the use of the M-CHAT follow-up interview in Spanish-speaking patients is beneficial but may be more time-consuming.
C1 [Kimple, Kelly S.; Bartelt, Erica A.; Wysocki, Karen L.; Steiner, Michael J.] Univ N Carolina, Chapel Hill, NC 27599 USA.
RP Kimple, KS (reprint author), Univ N Carolina, Dept Social Med, 121 MacNider Hall,CB 7240, Chapel Hill, NC 27599 USA.
EM kkimple@unch.unc.edu
CR Albores-Gallo L, 2012, ISRN NEUROL, V2012, DOI [DOI 10.5402/2012/408694, 10.5402/2012/408694]
Al-Qabandi M, 2011, PEDIATRICS, V128, pE211, DOI 10.1542/peds.2010-1881
Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
Canal-Bedia R, 2011, J AUTISM DEV DISORD, V41, P1342, DOI 10.1007/s10803-010-1163-z
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Chlebowski C, 2013, PEDIATRICS, V131, pE1121, DOI 10.1542/peds.2012-1525
Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
Dumont-Mathieu T, 2005, MENT RETARD DEV D R, V11, P253, DOI 10.1002/mrdd.20072
Fernandez K, 2007, PROF PSYCHOL-RES PR, V38, P363, DOI 10.1037/0735-7028.38.4.363
Inada N, 2011, RES AUTISM SPECT DIS, V5, P330, DOI 10.1016/j.rasd.2010.04.016
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kara B, 2014, AUTISM, V18, P331, DOI 10.1177/1362361312467864
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
Losapio M, 2008, REV PSIQUIATRIA RIO, V30, P221
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Palmer RF, 2010, AM J PUBLIC HEALTH, V100, P270, DOI 10.2105/AJPH.2008.150565
Pandey J, 2008, AUTISM, V12, P513, DOI 10.1177/1362361308094503
Pedersen A, 2012, PEDIATRICS, V129, pE629, DOI 10.1542/peds.2011-1145
Perera H, 2009, J TROP PEDIATRICS, V55, P402, DOI 10.1093/tropej/fmp031
Pinto-Martin JA, 2008, J DEV BEHAV PEDIATR, V29, P345, DOI 10.1097/DBP.0b013e31818914cf
Pintunan P, 2009, THAI J PEDIAT, V48, P221
Robins DL, 2006, J DEV BEHAV PEDIATR, V27, pS111, DOI 10.1097/00004703-200604002-00009
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
Schieve LA, 2012, DISABIL HEALTH J, V5, P18, DOI 10.1016/j.dhjo.2011.09.001
Seif Eldin Amira, 2008, Int Rev Psychiatry, V20, P281, DOI 10.1080/09540260801990324
Snow AV, 2008, AUTISM, V12, P627, DOI 10.1177/1362361308097116
Sunita, 2013, J PAEDIATR CHILD H, V49, P438, DOI 10.1111/j.1440-1754.2012.02558.x
U. S. Census Bureau, 2011, HISP POP 2010
Williams ME, 2009, J AUTISM DEV DISORD, V39, P660, DOI 10.1007/s10803-008-0668-1
Wong V, 2004, PEDIATRICS, V114, P166
Zuckerman KE, 2013, PEDIATRICS, V132, P445, DOI 10.1542/peds.2013-0383
NR 34
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
EI 1938-2707
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD JUN
PY 2014
VL 53
IS 7
BP 632
EP 638
DI 10.1177/0009922814522346
PG 7
WC Pediatrics
SC Pediatrics
GA AJ4GM
UT WOS:000337631200002
PM 24550559
ER
PT J
AU Bonora, E
Graziano, C
Minopoli, F
Bacchelli, E
Magini, P
Diquigiovanni, C
Lomartire, S
Bianco, F
Vargiolu, M
Parchi, P
Marasco, E
Mantovani, V
Rampoldi, L
Trudu, M
Parmeggiani, A
Battaglia, A
Mazzone, L
Tortora, G
Maestrini, E
Seri, M
Romeo, G
AF Bonora, Elena
Graziano, Claudio
Minopoli, Fiorella
Bacchelli, Elena
Magini, Pamela
Diquigiovanni, Chiara
Lomartire, Silvia
Bianco, Francesca
Vargiolu, Manuela
Parchi, Piero
Marasco, Elena
Mantovani, Vilma
Rampoldi, Luca
Trudu, Matteo
Parmeggiani, Antonia
Battaglia, Agatino
Mazzone, Luigi
Tortora, Giada
Maestrini, Elena
Seri, Marco
Romeo, Giovanni
CA IMGSAC
TI Maternally inherited genetic variants of CADPS2 are present in Autism
Spectrum Disorders and Intellectual Disability patients
SO EMBO MOLECULAR MEDICINE
LA English
DT Article
DE autism spectrum disorders; CADPS2; intellectual disability; monoallelic
expression; mutation screening
ID DE-NOVO MUTATIONS; CA2+-DEPENDENT ACTIVATOR PROTEIN; SECRETION 2;
NEUROTROPHIN RELEASE; HUMAN PEG1/MEST; CAPS2; METHYLATION; DISEASE;
BDNF; EXPRESSION
AB Intellectual disability (ID) and autism spectrum disorders (ASDs) are complex neuropsychiatric conditions, with overlapping clinical boundaries in many patients. We identified a novel intragenic deletion of maternal origin in two siblings with mild ID and epilepsy in the CADPS2 gene, encoding for a synaptic protein involved in neurotrophin release and interaction with dopamine receptor type 2 (D2DR). Mutation screening of 223 additional patients (187 with ASD and 36 with ID) identified a missense change of maternal origin disrupting CADPS2/D2DR interaction. CADPS2 allelic expression was tested in blood and different adult human brain regions, revealing that the gene was monoallelically expressed in blood and amygdala, and the expressed allele was the one of maternal origin. Cadps2 gene expression performed in mice at different developmental stages was biallelic in the postnatal and adult stages; however, a monoallelic (maternal) expression was detected in the embryonal stage, suggesting that CADPS2 is subjected to tissue- and temporal-specific regulation in human and mice. We suggest that CADPS2 variants may contribute to ID/ASD development, possibly through a parent-of-origin effect.
C1 [Bonora, Elena; Graziano, Claudio; Minopoli, Fiorella; Magini, Pamela; Diquigiovanni, Chiara; Bianco, Francesca; Vargiolu, Manuela; Mantovani, Vilma; Tortora, Giada; Seri, Marco; Romeo, Giovanni] Univ Bologna, S Orsola M Malpighi Hosp, Dept Med & Surg Sci, Unit Med Genet, Bologna, Italy.
[Minopoli, Fiorella; Bacchelli, Elena; Lomartire, Silvia; Maestrini, Elena] Univ Bologna, Dept Pharm & Biotechnol, Bologna, Italy.
[Parchi, Piero; Parmeggiani, Antonia] Univ Bologna, Dept Neurol, Bologna, Italy.
[Marasco, Elena; Mantovani, Vilma] St Orsola Marcello Malpighi Hosp, CRBA, Bologna, Italy.
[Rampoldi, Luca; Trudu, Matteo] Ist Sci San Raffaele, Div Genet & Cell Biol, Mol Genet Renal Disorders Unit, I-20132 Milan, Italy.
[Battaglia, Agatino] Stella Maris Clin Res Inst Child & Adolescent Neu, Pisa, Italy.
[Mazzone, Luigi] IRCCS Osped Pediat Bambino Gesu, Unit Child Neuropsychiat, Rome, Italy.
[IMGSAC] Newcastle Univ, IMGSAC Inst Neurosci & Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
RP Seri, M (reprint author), Univ Bologna, S Orsola M Malpighi Hosp, Dept Med & Surg Sci, Unit Med Genet, Bologna, Italy.
EM marco.seri@unibo.it
RI Bailey, Anthony/J-2860-2014
OI Bailey, Anthony/0000-0003-4257-972X
FU FP7-EU [223692]
FX We thank all the patients, families, and healthy volunteers that
participated in the study. We thank Prof. A. Contestabile for the
support in mouse brain expression analysis and Ms. M. Giambartolomei and
Dr. M. Vidone for technical help. This work was supported by FP7-EU
Grant No 223692 "CHERISH" to G. R.
CR Adzhubei I, 2013, CURR PROTOC HUM GENE, DOI DOI 10.1002/0471142905.HG0720S76
Binda AV, 2005, BIOCHEM PHARMACOL, V69, P451
Bonora E, 2002, MOL PSYCHIATR, V7, P289, DOI 10.1038/sj/mp/4001004
Centers for Disease Control, 2009, MMWR-MORBID MORTAL W, V58, P1
Cisternas FA, 2003, GENOMICS, V81, P279, DOI 10.1016/S0888-7543(02)00040-X
Coe BP, 2012, AM J MED GENET C, V160C, P118, DOI 10.1002/ajmg.c.31327
Di Vinci A, 2012, J CANCER RES CLIN, V138, P35, DOI 10.1007/s00432-011-1070-5
Ehrich M, 2005, P NATL ACAD SCI USA, V102, P15785, DOI 10.1073/pnas.0507816102
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
Green RE, 2010, SCIENCE, V328, P710, DOI 10.1126/science.1188021
Palferman S, 2001, AM J HUM GENET, V69, P570
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Izzi B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038579
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Kosaki K, 2000, AM J HUM GENET, V66, P309, DOI 10.1086/302712
Kuhn M, 2014, RESTOR NEUROL NEUROS, V32, P25, DOI 10.3233/RNN-139005
Lamb JA, 2005, J MED GENET, V42, P132, DOI 10.1136/jmg.2004.025668
Lee YJ, 2000, FEBS LETT, V472, P230, DOI 10.1016/S0014-5793(00)01461-7
Montine TJ, 2012, ACTA NEUROPATHOL, V123, P1, DOI 10.1007/s00401-011-0910-3
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Nurjono Milawaty, 2012, Clin Psychopharmacol Neurosci, V10, P61, DOI 10.9758/cpn.2012.10.2.61
Okamoto N, 2011, AM J MED GENET A, V155A, P1568, DOI 10.1002/ajmg.a.34028
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Riesewijk AM, 1997, GENOMICS, V42, P236, DOI 10.1006/geno.1997.4731
Sabens EA, 2010, BIOCHEMISTRY-US, V49, P2715, DOI 10.1021/bi9018658
Sadakata T, 2013, FEBS LETT, V587, P54, DOI 10.1016/j.febslet.2012.10.047
Sadakata T, 2004, J NEUROSCI, V24, P43, DOI 10.1523/JNEUROSCI.2528-03.2004
Sadakata T, 2010, NEUROSCI RES, V67, P197, DOI 10.1016/j.neures.2010.03.006
Sadakata T, 2007, J CLIN INVEST, V117, P931, DOI 10.1172/JCI29031
Sadakata T, 2012, FEBS J, V279, P384, DOI 10.1111/j.1742-4658.2011.08431.x
Sadakata T, 2012, P NATL ACAD SCI USA, V109, P21104, DOI 10.1073/pnas.1210055109
Sadakata T, 2007, J NEUROSCI, V27, P2472, DOI 10.1523/JNEUROSCI.2279-06.2007
Sadakata T, 2009, CEREBELLUM, V8, P312, DOI 10.1007/s12311-009-0097-5
Sadakata T, 2006, J COMP NEUROL, V495, P735, DOI 10.1002/cne.20947
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schneider E, 2012, CYTOGENET GENOME RES, V136, P278, DOI 10.1159/000337298
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Shaikh TH, 2009, GENOME RES, V19, P1682, DOI 10.1101/gr.083501.108
Shinoda Y, 2011, P NATL ACAD SCI USA, V108, P373, DOI 10.1073/pnas.1012220108
Suri D, 2013, BIOL PSYCHIAT, V73, P658, DOI 10.1016/j.biopsych.2012.10.023
van Bokhoven H, 2011, ANNU REV GENET, V45, P81, DOI 10.1146/annurev-genet-110410-132512
Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
NR 45
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-4676
EI 1757-4684
J9 EMBO MOL MED
JI EMBO Mol. Med.
PD JUN
PY 2014
VL 6
IS 6
BP 795
EP 809
DI 10.1002/emmm.201303235
PG 15
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AJ3DT
UT WOS:000337546600008
PM 24737869
ER
PT J
AU Davis, BA
Isles, AR
AF Davis, Brittany A.
Isles, Anthony R.
TI Modelling the genetic contribution to mental illness: a timely end for
the psychiatric rodent?
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE animal models; behavioural phenotyping; genes; mouse; neuropsychiatric
disorders
ID COPY NUMBER VARIATION; TOUCHSCREEN OPERANT PLATFORM; DE-NOVO MUTATIONS;
AUTISM SPECTRUM DISORDERS; GENOME-WIDE ASSOCIATION; FRAGILE-X-SYNDROME;
MOUSE MODEL; ALZHEIMERS-DISEASE; KLEEFSTRA SYNDROME; KNOCKOUT MICE
AB Rodent models are a key factor in the process of translating psychiatric genetics and genomics findings, allowing us to shed light on how risk-genes confer changes in neurobiology by merging different types of data across fields, from behavioural neuroscience to the burgeoning omics (e.g. genomics, epigenomics, proteomics, etc.). Moreover, they also provide an indispensable first step for drug discovery. However, recent evidence from both clinical and genetic studies highlights possible limitations in the current methods for classifying psychiatric illness, as both symptomology and underlying genetic risk are found to increasingly overlap across disorder diagnoses. Meanwhile, integration of data from animal models across disorders is currently limited. Here, we argue that behavioural neuroscience is in danger of missing informative data because of the practice of trying to diagnose' an animal model with a psychiatric illness. What is needed is a shift in emphasis, from seeking to ally an animal model to a specific disorder, to one focused on a more systematic assessment of the neurobiological and behavioural outcomes of any given genetic or environmental manipulation.
C1 [Davis, Brittany A.; Isles, Anthony R.] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Neurosci & Mental Hlth Res Inst, Cardiff CF24 4HQ, S Glam, Wales.
RP Isles, AR (reprint author), Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Neurosci & Mental Hlth Res Inst, Hadyn Ellis Bldg,Maindy Rd, Cardiff CF24 4HQ, S Glam, Wales.
EM IslesAR1@cardiff.ac.uk
FU Wellcome Trust
FX B.A.D. is funded by the Wellcome Trust. A. R. I. is a member of the MRC
Centre for Neuropsychiatric Genetics and Genomics.
CR Amann LC, 2010, BRAIN RES BULL, V83, P147, DOI 10.1016/j.brainresbull.2010.04.008
Amir RE, 1999, NAT GENET, V23, P185
Arguello P.A., 2012, TRENDS NEUROSCI, V35, P2
Balemans MCM, 2013, HUM MOL GENET, V22, P852, DOI 10.1093/hmg/dds490
Balemans MCM, 2010, BEHAV BRAIN RES, V208, P47, DOI 10.1016/j.bbr.2009.11.008
Boccuto L, 2013, EUR J HUM GENET, V21, P310, DOI 10.1038/ejhg.2012.175
Burmeister M, 2008, NAT REV GENET, V9, P527, DOI 10.1038/nrg2381
Chadman KK, 2009, AM J MED GENET B, V150B, P1, DOI 10.1002/ajmg.b.30777
Chapman J, 2013, HUM MOL GENET, V22, P816, DOI 10.1093/hmg/dds476
Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
Comoletti D, 2004, J NEUROSCI, V24, P4889, DOI 10.1523/JNEUROSCI.0468-04.2004
Cook EH, 1997, AM J HUM GENET, V60, P928
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Crabbe JC, 1999, SCIENCE, V284, P1670, DOI 10.1126/science.284.5420.1670
Craddock N, 2006, SCHIZOPHRENIA BULL, V32, P9, DOI 10.1093/schbul/sbj033
Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429
Crespi B, 2010, P NATL ACAD SCI USA, V107, P1736, DOI 10.1073/pnas.0906080106
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Dahlhaus R, 2010, BEHAV BRAIN RES, V208, P96, DOI 10.1016/j.bbr.2009.11.019
Danchin E, 2011, NAT REV GENET, V12, P475, DOI 10.1038/nrg3028
Doyle AE, 2005, BIOL PSYCHIAT, V57, P1324, DOI 10.1016/j.biopsych.2005.03.015
Eagle DM, 2008, PSYCHOPHARMACOLOGY, V199, P439, DOI 10.1007/s00213-008-1127-6
Egan CM, 2007, NAT GENET, V39, P1384, DOI 10.1038/ng.2007.19
Fromer M, 2014, NATURE, V506, P179, DOI 10.1038/nature12929
Gerlai R, 1996, TRENDS NEUROSCI, V19, P177, DOI 10.1016/S0166-2236(96)20020-7
Gershon ES, 2011, AM J PSYCHIAT, V168, P253, DOI 10.1176/appi.ajp.2010.10091340
GEYER MA, 1990, BRAIN RES BULL, V25, P485, DOI 10.1016/0361-9230(90)90241-Q
Geyer MA, 2002, MOL PSYCHIATR, V7, P1039, DOI 10.1038/sj.mp.4001159
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Gogos JA, 2006, TRENDS PHARMACOL SCI, V27, P226, DOI 10.1016/j.tips.2006.02.005
Gothelf D, 2007, CHILD ADOL PSYCH CL, V16, P677, DOI 10.1016/j.chc.2007.03.005
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
Green T, 2009, J AM ACAD CHILD PSY, V48, P1060, DOI 10.1097/CHI.0b013e3181b76683
Grozeva D, 2013, BIPOLAR DISORD, V15, P893, DOI 10.1111/bdi.12125
Guryev V, 2008, NAT GENET, V40, P538, DOI 10.1038/ng.141
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hamshere ML, 2013, BRIT J PSYCHIAT, V203, P107, DOI 10.1192/bjp.bp.112.117432
Harold D, 2009, NAT GENET, V41, P1088, DOI 10.1038/ng.440
Hines RM, 2008, J NEUROSCI, V28, P6055, DOI 10.1523/JNEUROSCI.0032-08.2008
Horner AE, 2013, NAT PROTOC, V8, P1961, DOI 10.1038/nprot.2013.122
Humby T, 2011, CURR OPIN PHARMACOL, V11, P534, DOI 10.1016/j.coph.2011.06.006
Humby T., 2005, CURR PROTOC NEUROSCI, V8, p85H
Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
Ingason A, 2011, AM J PSYCHIAT, V168, P408, DOI 10.1176/appi.ajp.2010.09111660
Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Jiang YH, 1998, CURR OPIN GENET DEV, V8, P334, DOI 10.1016/S0959-437X(98)80091-9
Kellendonk C, 2009, TRENDS NEUROSCI, V32, P347, DOI 10.1016/j.tins.2009.02.003
Kendler KS, 2010, MOL PSYCHIATR, V15, P789, DOI 10.1038/mp.2010.8
Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
Kleefstra T., 2010, GENEREVIEWS
Kohl C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056871
Koscielny G, 2014, NUCLEIC ACIDS RES, V42, pD802, DOI 10.1093/nar/gkt977
Kounali D., 2014, PSYCHOL MED, P1
Kwon HB, 2012, NAT NEUROSCI, V15, P1667, DOI 10.1038/nn.3256
Lambert JC, 2013, NAT GENET, V45, P1452, DOI 10.1038/ng.2802
Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006
Lee SH, 2011, AM J HUM GENET, V88, P294, DOI 10.1016/j.ajhg.2011.02.002
Lee SH, 2013, NAT GENET, V45, P984, DOI 10.1038/ng.2711
Liao HM, 2012, SCHIZOPHR RES, V139, P229, DOI 10.1016/j.schres.2012.05.015
Lise MF, 2006, CELL MOL LIFE SCI, V63, P1833, DOI 10.1007/s00018-006-6061-3
Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
Mar AC, 2013, NAT PROTOC, V8, P1985, DOI 10.1038/nprot.2013.123
Martin Christa Lese, 2007, Curr Psychiatry Rep, V9, P141
McConnell MJ, 2013, SCIENCE, V342, P632, DOI 10.1126/science.1243472
Miller GA, 2013, ANNU REV CLIN PSYCHO, V9, P177, DOI 10.1146/annurev-clinpsy-050212-185540
MYERS RH, 1993, NAT GENET, V5, P168, DOI 10.1038/ng1093-168
Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
Oomen CA, 2013, NAT PROTOC, V8, P2006, DOI 10.1038/nprot.2013.124
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Parker CC, 2014, NEUROPHARMACOLOGY, V76, P250, DOI 10.1016/j.neuropharm.2013.05.047
Pratt J, 2012, NAT REV DRUG DISCOV, V11, P560, DOI 10.1038/nrd3649
Redon R, 2006, NATURE, V444, P444, DOI 10.1038/nature05329
Rees E, 2014, BRIT J PSYCHIAT, V204, P108, DOI 10.1192/bjp.bp.113.131052
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Robbins TW, 2012, TRENDS COGN SCI, V16, P81, DOI 10.1016/j.tics.2011.11.009
Robbins TW, 2002, PSYCHOPHARMACOLOGY, V163, P362, DOI 10.1107/s00213-002-1154-7
Sebat J, 2004, SCIENCE, V305, P525, DOI 10.1126/science.1098918
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Smith SE, 2011, SCI TRANSL MED, V3
Stewart LR, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-154
Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
Sun CC, 2011, HUM MOL GENET, V20, P3042, DOI 10.1093/hmg/ddr208
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
Tamada K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015126
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Walters JTR, 2007, MOL PSYCHIATR, V12, P886, DOI 10.1038/sj.mp.4002068
Willemsen MH, 2011, CLIN GENET, V80, P31, DOI 10.1111/j.1399-0004.2010.01607.x
Winstanley CA, 2006, CLIN PSYCHOL REV, V26, P379, DOI 10.1016/j.cpr.2006.01.001
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Zhang C, 2009, J NEUROSCI, V29, P10843, DOI 10.1523/JNEUROSCI.1248-09.2009
NR 99
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD JUN
PY 2014
VL 39
IS 11
SI SI
BP 1933
EP 1942
DI 10.1111/ejn.12607
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AJ3BT
UT WOS:000337540800020
PM 24862335
ER
PT J
AU Abu-Hamour, B
Muhaidat, M
AF Abu-Hamour, Bashir
Muhaidat, Mohammad
TI Parents' attitudes towards inclusion of students with autism in Jordan
SO INTERNATIONAL JOURNAL OF INCLUSIVE EDUCATION
LA English
DT Article
DE special education; autism spectrum disorder; inclusion; students with
special needs
ID SEVERE DISABILITIES; SPECTRUM DISORDERS; YOUNG-CHILDREN; PERCEPTIONS;
TEACHERS; SCHOOL; PERSPECTIVES; INTEGRATION; EDUCATION; SETTINGS
AB This study investigated the attitudes of parents in Jordan towards the inclusion of students with autism spectrum disorder (ASD) in public schools and what the parents believed to be the most important prerequisite of child-based skills for successful inclusion. A total of 148 parents were selected to complete the survey. The researchers explored whether variable demographic characteristics such as age, student's gender, parent's gender, education levels, monthly income, and high-or low-function ASD correlated with the attitudes of parents towards inclusion of students with ASD in public schools. The analyses revealed that the variables that correlated with parents' attitudes towards inclusion were education levels and high-or low-function ASD. The themes behind the parents' attitude for inclusion are discussed. With regard to the prerequisite skills for successful inclusion, the results indicated that parents recommended independent skills, playing skills, behavioural skills, imitation skills, routine skills, social skills, paying attention skills, language skills, and pre-academic and academic skills in that order.
C1 [Abu-Hamour, Bashir] Mutah Univ, Dept Counseling & Special Educ, Fac Educ Sci, Mutah Al Karak 61710, Jordan.
[Muhaidat, Mohammad] Al Yarmouk Univ, Dept Counseling & Educ Psychol, Irbid, Jordan.
RP Abu-Hamour, B (reprint author), Mutah Univ, Dept Counseling & Special Educ, Fac Educ Sci, POB 6, Mutah Al Karak 61710, Jordan.
EM dr.abuhamourwj@gmail.com
CR Al-Rossan F., 2012, INTRO SPECIAL ED
Al-Zyoudi M., 2006, INT J SPECIAL ED, V21, P55
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Avramidis E., 2000, EDUC PSYCHOL, V20, P191, DOI DOI 10.1080/713663717
Baker E. T., 1994, EDUC LEADERSHIP, V52, P3
Balboni G, 2000, EDUC TRAIN MENT RET, V35, P148
Bennett T, 1997, EXCEPT CHILDREN, V64, P115
BUYSSE V, 1993, J SPEC EDUC, V26, P434
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Cole K. N., 1991, EXCEPT CHILDREN, V58, P1
De Boer A. A., 2010, EUROPEAN J SPECIAL N, V25, P165, DOI [10.1080/08856251003658694, DOI 10.1080/08856251003658694]
Eaves LC, 1997, J DEV PHYS DISABIL, V9, P277, DOI 10.1023/A:1024944226971
English A., 2008, ED PROVISION CHILDRE
Field A., 2009, DISCOVERING STAT USI
Fox NE, 1997, EXCEPT CHILDREN, V64, P81
Gallagher PA, 2000, EDUC TRAIN MENT RET, V35, P135
Grove KA, 1999, REM SPEC EDUC, V20, P208, DOI 10.1177/074193259902000404
Halvorsen A. T., 2001, BUILDING INCLUSIVE S
Hamilton Wentworth District School Board, 2006, PLANN ENTR SCH RES G
Handleman J. S., 2006, SCH AGE ED PROGRAMS, P93
HANLINE MF, 1989, EXCEPT CHILDREN, V55, P487
Healthy Child Manitoba, 2002, GUID EARL CHILDH TRA
Hundert J, 1998, EARLY CHILD RES Q, V13, P49, DOI 10.1016/S0885-2006(99)80025-8
Janus M., 2007, CANADIAN J ED, V30, P628
Jordan R., 2005, SPECIAL TEACHING SPE, P110
Kasari C, 1999, J AUTISM DEV DISORD, V29, P297, DOI 10.1023/A:1022159302571
Lerman DC, 2004, SCHOOL PSYCHOL REV, V33, P510
Leyser Y., 2004, INT J DISABIL DEV ED, V51, P271, DOI [10.1080/1034912042000259233, DOI 10.1080/1034912042000259233]
Marshall C., 2006, DESIGNING QUALITATIV, V4th
MCDONNELL J, 1987, EDUC TRAIN MENT RET, V22, P98
McGregor E, 2001, AUTISM, V5, P189
Mitchell D., 2004, SPECIAL ED NEEDS INC
National Institute of Mental Health, 2009, WHAT AR AUT SPECTR D
Nisbet J., 1994, ED REFORM SUMMARY RE
Palmer DS, 2001, EXCEPT CHILDREN, V67, P467
Perko S, 2002, INT J SPECIAL ED, V17, P59
Prizant B., 2001, AUTISM SPECTRUM DISO
RYNDAK DL, 1995, J ASSOC PERS SEVERE, V20, P147
Siegel B., 1996, WORLD AUTISTIC CHILD
Simpson RL, 2004, EXCEPT CHILDREN, V70, P135
SPSS Inc, 2008, SPSS BAS 16 0 WIND U
Starr EM, 2001, EDUC TRAIN MENT RET, V36, P55
Stoiber KC, 1998, EARLY CHILD RES Q, V13, P107, DOI 10.1016/S0885-2006(99)80028-3
The Higher Council for the Affairs of Persons with Disabilities, 2007, LAW RIGHTS PERS DIS
Turnbull A. P., 1997, FAMILIES PROFESSIONA
Turnbull R., 2002, EXCEPTIONAL LIVES SP
NR 46
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1360-3116
EI 1464-5173
J9 INT J INCLUSIVE EDUC
JI Int. J. Incl. Educ.
PD JUN
PY 2014
VL 18
IS 6
BP 567
EP 579
DI 10.1080/13603116.2013.802026
PG 13
WC Education & Educational Research
SC Education & Educational Research
GA AJ3HW
UT WOS:000337558100002
ER
PT J
AU Carroll, RA
Kodak, T
AF Carroll, Regina A.
Kodak, Tiffany
TI An evaluation of interrupted and uninterrupted measurement of vocal
stereotypy on perceived treatment outcomes
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE automatic reinforcement; noncontingent reinforcement; response
interruption and redirection; vocal stereotypy; data analysis
ID AUTISM SPECTRUM DISORDERS; RESPONSE INTERRUPTION; MATCHED STIMULATION;
REPETITIVE BEHAVIOR; REDIRECTION; CHILDREN; REPLICATION; PREFERENCE;
IMMEDIATE
AB The type of procedure used to measure a target behavior may directly influence the perceived treatment outcomes. In the present study, we examined the influence of different data-analysis procedures on the outcomes of two commonly used treatments on the vocal stereotypy of 2 children with an autism spectrum disorder. In Study 1, we compared an interrupted and uninterrupted data-analysis procedure to measure vocal stereotypy during the implementation of response interruption and redirection (RIRD). The results showed that the interrupted data-analysis procedure overestimated the effectiveness of RIRD. In Study 2, we examined the influence of different data-analysis procedures on the interpretation of the relative effects of 2 different treatments for vocal stereotypy. Specifically, we compared interrupted and uninterrupted data-analysis procedures during the implementation of RIRD and noncontingent reinforcement (NCR) as a treatment for vocal stereotypy. The results showed that, as in Study 1, the interrupted data-analysis procedure overestimated the effectiveness of RIRD; however, this effect was not apparent with NCR. These findings suggest that different types of data analysis can influence the perceived success of a treatment.
C1 [Carroll, Regina A.] W Virginia Univ, Morgantown, WV 26506 USA.
[Kodak, Tiffany] Univ Oregon, Eugene, OR 97403 USA.
RP Carroll, RA (reprint author), W Virginia Univ, Dept Psychol, Life Sci Room 1232,53 Campus Dr, Morgantown, WV 26506 USA.
EM racarroll@mail.wvu.edu
CR Ahearn WH, 2007, J APPL BEHAV ANAL, V40, P263, DOI 10.1901/jaba.2007.30-06
Ahrens EN, 2011, J APPL BEHAV ANAL, V44, P95, DOI 10.1901/jaba.2011.44-95
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
Cassella MD, 2011, J APPL BEHAV ANAL, V44, P169, DOI 10.1901/jaba.2011.44-169
Colon CL, 2012, J APPL BEHAV ANAL, V45, P107, DOI 10.1901/jaba.2012.45-107
Cooper J. O., 2007, APPL BEHAV ANAL
Cummings AR, 2009, J APPL BEHAV ANAL, V42, P57, DOI 10.1901/jaba.2009.42-57
Giles AF, 2012, RES DEV DISABIL, V33, P1691, DOI 10.1016/j.ridd.2012.05.008
Iwata Brian A, 2008, Behav Anal Pract, V1, P3
KOEGEL RL, 1972, J APPL BEHAV ANAL, V5, P381, DOI 10.1901/jaba.1972.5-381
Lang R, 2010, BEHAV MODIF, V34, P267, DOI 10.1177/0145445510370713
Lanovaz MJ, 2009, BEHAV MODIF, V33, P682, DOI 10.1177/0145445509344972
Lanovaz MJ, 2012, BEHAV MODIF, V36, P146, DOI 10.1177/0145445511427192
Lewis MH, 1998, MENT RETARD DEV D R, V4, P80, DOI 10.1002/(SICI)1098-2779(1998)4:2<80::AID-MRDD4>3.0.CO;2-0
Liu-Gitz L, 2010, BEHAV INTERVENT, V25, P77, DOI 10.1002/bin.297
Love JJ, 2012, J APPL BEHAV ANAL, V45, P549, DOI 10.1901/jaba.2012.45-549
Miguel CF, 2009, J APPL BEHAV ANAL, V42, P883, DOI 10.1901/jaba.2009.42-883
Mudford OC, 2009, J APPL BEHAV ANAL, V42, P165, DOI 10.1901/jaba.2009.42-165
Piazza CC, 2000, J APPL BEHAV ANAL, V33, P13, DOI 10.1901/jaba.2000.33-13
Rapp JT, 2007, J APPL BEHAV ANAL, V40, P73, DOI 10.1901/jaba.2007.142-05
Rapp JT, 2013, BEHAV MODIF, V37, P543, DOI 10.1177/0145445512461650
Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
Rapp JT, 2001, BEHAV MODIF, V25, P79, DOI 10.1177/0145445501251005
Rapp JT, 2008, BEHAV INTERVENT, V23, P237, DOI 10.1002/bin.269
Rapp JT, 2006, J APPL BEHAV ANAL, V39, P137, DOI 10.1901/jaba.2006.37-05
Roane HS, 1998, J APPL BEHAV ANAL, V31, P605, DOI 10.1901/jaba.1998.31-605
Schumacher BI, 2011, J APPL BEHAV ANAL, V44, P681, DOI 10.1901/jaba.2011.44-681
NR 28
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2014
VL 47
IS 2
BP 264
EP 276
DI 10.1002/jaba.118
PG 13
WC Psychology, Clinical
SC Psychology
GA AJ3YO
UT WOS:000337604500004
PM 24764249
ER
PT J
AU Garcia-Albea, E
Reeve, SA
Reeve, KF
Brothers, KJ
AF Garcia-Albea, Elena
Reeve, Sharon A.
Reeve, Kenneth F.
Brothers, Kevin J.
TI Using audio script fading and multiple-exemplar training to increase
vocal interactions in children with autism
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; multiple-exemplar training; scripts; script fading; spontaneous
language
ID SOCIAL-INTERACTION SKILLS; GENERALIZED REPERTOIRE; TEACHING-CHILDREN;
ACQUISITION; LANGUAGE
AB Script-fading procedures have been shown to be effective for teaching children with autism to initiate and participate in social interactions without vocal prompts from adults. In previous script and script-fading research, however, there has been no demonstration of a generalized repertoire of vocal interactions under the control of naturally occurring relevant stimuli. In this study, 4 boys with autism were taught to initiate a conversation in the presence of toys through the use of a script and script-fading procedure. Training with multiple categories and exemplars of toys was used to increase the likelihood of generalization of vocal interactions across novel toys. A multiple-probe design across participants was used to assess the effects of these procedures. The intervention successfully brought interactions by children with autism under the control of relevant stimuli in the environment. Future research pertaining to the specific implementation of these procedures (e.g., fading, script placement, participant characteristics) is discussed.
C1 [Garcia-Albea, Elena; Reeve, Sharon A.; Reeve, Kenneth F.] Caldwell Coll, Caldwell, NJ 07006 USA.
[Brothers, Kevin J.] Somerset Hills Learning Inst, Bedminster Township, NJ USA.
RP Reeve, SA (reprint author), Caldwell Coll, Dept Appl Behav Anal, 120 Bloomfield Ave, Caldwell, NJ 07006 USA.
EM sreeve@caldwell.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Brown JL, 2008, RES AUTISM SPECT DIS, V2, P480, DOI 10.1016/j.rasd.2007.08.006
CARR EG, 1983, J APPL BEHAV ANAL, V16, P297, DOI 10.1901/jaba.1983.16-297
Carr JE, 2000, J APPL BEHAV ANAL, V33, P353, DOI 10.1901/jaba.2000.33-353
CHARLOP MH, 1985, J APPL BEHAV ANAL, V18, P155, DOI 10.1901/jaba.1985.18-155
CHARLOP MH, 1991, J APPL BEHAV ANAL, V24, P747, DOI 10.1901/jaba.1991.24-747
Cowan RJ, 2007, PSYCHOL SCHOOLS, V44, P701, DOI 10.1002/pits.20259
Engelmann S., 1982, THEORY INSTRUCTION P
Horner R. H., 1982, DESIGN HIGH SCH PROG, P61
Krantz PJ, 1998, J APPL BEHAV ANAL, V31, P191, DOI 10.1901/jaba.1998.31-191
KRANTZ PJ, 1993, J APPL BEHAV ANAL, V26, P121, DOI 10.1901/jaba.1993.26-121
MacDuff JL, 2007, RES AUTISM SPECT DIS, V1, P281, DOI 10.1016/j.rasd.2006.11.003
Marzullo-Kerth D, 2011, J APPL BEHAV ANAL, V44, P279, DOI 10.1901/jaba.2011.44-279
MATSON JL, 1990, J APPL BEHAV ANAL, V23, P227, DOI 10.1901/jaba.1990.23-227
MCGEE GG, 1983, J APPL BEHAV ANAL, V16, P329, DOI 10.1901/jaba.1983.16-329
Osnes P. G., 2003, BEHAV ANAL TODAY, V3, P364
Reagon KA, 2009, J APPL BEHAV ANAL, V42, P659, DOI 10.1901/jaba.2009.42-659
Reeve SA, 2007, J APPL BEHAV ANAL, V40, P123, DOI 10.1901/jaba.2007.11-05
Reimers T. M., 1988, BEHAVIORAL DISORDERS, V14, P7
Sarokoff RA, 2001, J APPL BEHAV ANAL, V34, P81, DOI 10.1901/jaba.2001.34-81
Stevenson CL, 2000, BEHAV INTERVENT, V15, P1, DOI 10.1002/(SICI)1099-078X(200001/03)15:1<1::AID-BIN41>3.0.CO;2-V
STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
Zimmerman I.L., 1992, PRESCHOOL LANGUAGE S
NR 23
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2014
VL 47
IS 2
BP 325
EP 343
DI 10.1002/jaba.125
PG 19
WC Psychology, Clinical
SC Psychology
GA AJ3YO
UT WOS:000337604500008
PM 24763913
ER
PT J
AU Armstrong, A
Knapp, VM
McAdam, DB
AF Armstrong, Amy
Knapp, Vicki Madaus
McAdam, David B.
TI Functional analysis and treatment of the diurnal bruxism of a
16-year-old girl with autism
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE bruxism; functional analysis; vocal reprimand
ID ABERRANT BEHAVIOR; INTERVENTION
AB Bruxism is defined as the clenching and grinding of teeth. This study used a functional analysis to examine whether the bruxism of a 16-year-old girl with autism was maintained by automatic reinforcement or social consequences. A subsequent component analysis of the intervention package described by Barnoy, Najdowski, Tarbox, Wilke, and Nollet (2009) showed that a vocal reprimand (e.g., stop grinding) effectively reduced the participant's bruxism. Results were maintained across time, and effects extended to novel staff members.
C1 [Armstrong, Amy; Knapp, Vicki Madaus] Summit Educ Resources, Getzville, NY 14068 USA.
[McAdam, David B.] Univ Rochester, Sch Med, Rochester, NY 14627 USA.
RP Knapp, VM (reprint author), Summit Educ Resources, 150 Stahl Rd, Getzville, NY 14068 USA.
EM vmknapp@summited.org
CR BARLOW DH, 1979, J APPL BEHAV ANAL, V12, P199, DOI 10.1901/jaba.1979.12-199
Barnoy EL, 2009, J APPL BEHAV ANAL, V42, P845, DOI 10.1901/jaba.2009.42-845
DeMattei R., 2007, J DENT HYGIENE, V81, P1
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Lang R, 2009, RES DEV DISABIL, V30, P809, DOI 10.1016/j.ridd.2008.12.006
Lang R, 2013, J APPL BEHAV ANAL, V46, P322, DOI 10.1002/jaba.5
Paclawskyj TR, 2000, RES DEV DISABIL, V21, P223, DOI 10.1016/S0891-4222(00)00036-6
Shirley MJ, 1999, J APPL BEHAV ANAL, V32, P201, DOI 10.1901/jaba.1999.32-201
THOMPSON BA, 1994, AM FAM PHYSICIAN, V49, P1617
Vollmer TR, 1995, J APPL BEHAV ANAL, V28, P561, DOI 10.1901/jaba.1995.28-561
NR 10
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2014
VL 47
IS 2
BP 415
EP 419
DI 10.1002/jaba.122
PG 5
WC Psychology, Clinical
SC Psychology
GA AJ3YO
UT WOS:000337604500014
PM 24740489
ER
PT J
AU Loughrey, TO
Betz, AM
Majdalany, LM
Nicholson, K
AF Loughrey, Tara Olivia
Betz, Alison M.
Majdalany, Lina M.
Nicholson, Katie
TI Using instructive feedback to teach category names to children with
autism
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; instructive feedback; verbal behavior
AB We evaluated the effects of instructive feedback (IF) on the emergence of spoken category names with 2 children who had been diagnosed with autism. IF stimuli were presented during listener discrimination training and consisted of presenting the category name associated with each target stimulus. Results suggest that participants acquired the speaker relations in the absence of prompting and reinforcement. Clinical implications and future research on the use of IF as a teaching procedure for children with autism are discussed.
C1 Florida Inst Technol, Melbourne, FL 32901 USA.
Scott Ctr Autism Treatment, Melbourne, FL USA.
RP Betz, AM (reprint author), Florida Inst Technol, Sch Psychol, 150 W Univ Blvd, Melbourne, FL 32901 USA.
EM abetz@fit.edu
CR Carr JE, 2000, J APPL BEHAV ANAL, V33, P353, DOI 10.1901/jaba.2000.33-353
Reichow B, 2011, J APPL BEHAV ANAL, V44, P327, DOI 10.1901/jaba.2011.44-327
Sundberg M. L., 2008, VBMAPP VERBAL BEHAV
Werts M. G., 1995, J BEHAV ED, V5, P55, DOI 10.1007/BF02110214
Wynn JW, 2003, BEHAV INTERVENT, V18, P245, DOI 10.1002/bin.142
NR 5
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2014
VL 47
IS 2
BP 425
EP 430
DI 10.1002/jaba.123
PG 6
WC Psychology, Clinical
SC Psychology
GA AJ3YO
UT WOS:000337604500016
PM 24740544
ER
PT J
AU Kobari-Wright, VV
Miguel, CF
AF Kobari-Wright, Vissy V.
Miguel, Caio F.
TI The effects of listener training on the emergence of categorization and
speaker behavior in children with autism
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; categorization; listener; naming; verbal behavior
AB We evaluated the effects of listener training on the emergence of categorization and speaker behavior (i.e., tacts) using a nonconcurrent multiple baseline design. Four children with autism learned to select pictures given their dictated category names. We assessed whether they could match and tact pictures by category. After training, 3 participants tacted and categorized all pictures, and 1 participant failed both tests. After tact training, this participant categorized. These results suggest that listener training may be an efficient way to produce speaker behavior and categorization in children who have been diagnosed with autism.
C1 [Kobari-Wright, Vissy V.; Miguel, Caio F.] Calif State Univ Sacramento, Sacramento, CA 95819 USA.
RP Miguel, CF (reprint author), Calif State Univ Sacramento, Dept Psychol, 6000 J St, Sacramento, CA 95819 USA.
EM miguelc@csus.edu
CR Greer R. D., 2007, EUROPEAN J BEHAV ANA, V8, P109
Horne PJ, 2004, J EXP ANAL BEHAV, V81, P267, DOI 10.1901/jeab.2004.81-267
Horne PJ, 1996, J EXP ANAL BEHAV, V65, P185, DOI 10.1901/jeab.1996.65-185
Miguel C. F., 2009, DERIVED RELATIONAL R, P129
Miguel CF, 2008, J EXP ANAL BEHAV, V89, P383, DOI 10.1901/jeab.2008-89-383
Miguel CF, 2013, J APPL BEHAV ANAL, V46, P669, DOI 10.1002/jaba.62
Petursdottir AI, 2011, J APPL BEHAV ANAL, V44, P859, DOI 10.1901/jaba.2011.44-859
Sprinkle Evelyn C, 2012, Anal Verbal Behav, V28, P111
Sundberg M. L., 2008, VERBAL BEHAV MILESTO
Voress J, 1998, DEV ASSESSMENT YOUNG
VORT Corporation, 1995, HELP PRESCH ASS STRA
NR 11
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2014
VL 47
IS 2
BP 431
EP 436
DI 10.1002/jaba.115
PG 6
WC Psychology, Clinical
SC Psychology
GA AJ3YO
UT WOS:000337604500017
PM 24740431
ER
PT J
AU Rosales, R
Maderitz, C
Garcia, YA
AF Rosales, Rocio
Maderitz, Cecelia
Garcia, Yors A.
TI Comparison of simple and complex auditory-visual conditional
discrimination training
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE complex samples; conditional discriminations
ID SAMPLES; BEHAVIOR; CHILDREN; AUTISM
AB We investigated the relative effects of simple and complex auditory-visual discrimination training using an adapted alternating treatments design to establish derived stimulus relations in 2 children who had been diagnosed with autism and 1 typically developing peer. Emergence of untrained conditional relations was observed after training in both conditions, with a possible advantage of simple-sample training for 1 participant. Results of generalization and follow-up probes were mixed.
C1 [Rosales, Rocio; Maderitz, Cecelia] Youngstown State Univ, Youngstown, OH USA.
[Garcia, Yors A.] Fdn Univ Konrad Lorenz, Urbana, IL USA.
RP Rosales, R (reprint author), Univ Massachusetts, Dept Psychol, 113 Wilder St,Suite 300, Lowell, MA 01854 USA.
EM rocio_rosales@uml.edu
CR Groskreutz NC, 2010, J APPL BEHAV ANAL, V43, P131, DOI 10.1901/jaba.2010.43-131
Harper Dittlinger L., 2011, J APPL BEHAV ANAL, V44, P341, DOI [10.1901/jaba.2011.44-341, DOI 10.1901/JABA.2011.44-341]
Horne PJ, 1996, J EXP ANAL BEHAV, V65, P185, DOI 10.1901/jeab.1996.65-185
Lane SD, 1998, J APPL BEHAV ANAL, V31, P21, DOI 10.1901/jaba.1998.31-21
MAGUIRE RW, 1994, J AUTISM DEV DISORD, V24, P753, DOI 10.1007/BF02172284
Rehfeldt RA, 2011, J APPL BEHAV ANAL, V44, P109, DOI 10.1901/jaba.2011.44-109
SIDMAN M, 1971, J SPEECH HEAR RES, V14, P5
STROMER R, 1992, J APPL BEHAV ANAL, V25, P893, DOI 10.1901/jaba.1992.25-893
NR 8
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2014
VL 47
IS 2
BP 437
EP 442
DI 10.1002/jaba.121
PG 6
WC Psychology, Clinical
SC Psychology
GA AJ3YO
UT WOS:000337604500018
PM 24764261
ER
PT J
AU Loe, IM
Feldman, HM
Huffman, LC
AF Loe, Irene M.
Feldman, Heidi M.
Huffman, Lynne C.
TI Executive Function Mediates Effects of Gestational Age on Functional
Outcomes and Behavior in Preschoolers
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE premature birth; preterm; executive function; adaptive function;
reading; behavior; mediation
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS;
BIRTH-WEIGHT CHILDREN; WORKING-MEMORY; PRETERM CHILDREN;
ACADEMIC-ACHIEVEMENT; FUNCTION IMPAIRMENT; PROCESSING SPEED; RATING
INVENTORY; BRAIN-INJURY
AB Objective: To investigate the role of executive function (EF) skills, measured by parent-rating and performance-based instruments, as mediators of the effects of gestational age (GA) on functional outcomes and behavior symptoms in preterm (PT) and full-term (FT) preschoolers. Patients and Methods: Children born PT (n = 70; mean GA, 29.6 weeks; mean birth weight, 1365 g) were compared to children born FT (n 5 79) on composite measures of EF (using the Behavior Rating Inventory of Executive Function and a performance-based EF battery), adaptive function, prereading skills, and behavior symptoms. For the entire sample, mediation analyses examined the effect of GA on the outcomes with EF as mediator. Results: Compared to children born FT, children born PT had significantly higher parent-rated EF scores and lower performance-based EF scores, both indicating more problems; furthermore, children born PT had lower adaptive function and prereading scores and more problematic behavior. GA contributed to adaptive function, prereading skills, and behavior symptoms for all children. EF acted as a mediator of GA for all 3 outcomes; different patterns emerged for parent-rated and performance-based EF evaluations. For adaptive function, both EF measures significantly mediated the effects of GA; for prereading skills, only performance-based EF was significant; for behavior symptoms, only parent-rated EF was significant. Conclusions: We propose standard assessment of EF, using both parent-rating and performance-based EF measures, in young PT children and other children at the risk of EF impairments. EF skills are measurable, mediate important functional outcomes, and may serve as intervention targets.
C1 [Loe, Irene M.; Feldman, Heidi M.; Huffman, Lynne C.] Stanford Univ, Dept Pediat, Sch Med, Div Neonatal & Dev Med, Stanford, CA 94305 USA.
RP Loe, IM (reprint author), Stanford Univ, 750 Welch Rd,Suite 315, Palo Alto, CA 94304 USA.
EM iloe@stanford.edu
FU Child Health Research Institute of Stanford University; Lucile Packard
Foundation for Children's Health; Society for Developmental-Behavioral
Pediatrics under the Young Investigator Award; Eunice Kennedy Shriver
National Institute of Child Health and Human Development, National
Institutes of Health [K23HD071971]; National Center for Research
Resources, National Institutes of Health under the Stanford Clinical and
Translational Science Award [UL1 TR001085]
FX The work was supported by the Child Health Research Institute of
Stanford University and Lucile Packard Foundation for Children's Health
under a Pilot Early Career Grant, the Society for
Developmental-Behavioral Pediatrics under the Young Investigator Award,
and the Eunice Kennedy Shriver National Institute of Child Health and
Human Development, National Institutes of Health, under the Mentored
Patient-oriented Research Career Development Award Grant (K23HD071971)
to I.M.L.; and the National Center for Research Resources, National
Institutes of Health under the Stanford Clinical and Translational
Science Award (UL1 TR001085).
CR Aarnoudse-Moens CSH, 2009, J ABNORM CHILD PSYCH, V37, P981, DOI 10.1007/s10802-009-9327-z
Aarnoudse-Moens CSH, 2009, PEDIATRICS, V124, P717, DOI 10.1542/peds.2008-2816
Aarnoudse-Moens CSH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055994
Achenbach T, 2000, MANUAL ASEBA PRESCHO
Anderson P, 2002, CHILD NEUROPSYCHOL, V8, P71
Aylward GP, 2005, J DEV BEHAV PEDIATR, V26, P427, DOI 10.1097/00004703-200512000-00008
Baron R. M., 1986, J PERS SOC PSYCHOL, V51, P1172
Blair C, 2007, CHILD DEV, V78, P647, DOI 10.1111/j.1467-8624.2007.01019.x
Brocki KC, 2010, J ABNORM CHILD PSYCH, V38, P163, DOI 10.1007/s10802-009-9354-9
Bull R, 2001, DEV NEUROPSYCHOL, V19, P273, DOI 10.1207/S15326942DN1903_3
Cahn-Weiner Deborah A, 2002, Appl Neuropsychol, V9, P187, DOI 10.1207/S15324826AN0903_8
Cameron CE, 2012, CHILD DEV, V83, P1229, DOI 10.1111/j.1467-8624.2012.01768.x
Carlson SA, 2005, DEV NEUROPSYCHOL, V28, P595, DOI 10.1207/s15326942dn2802_3
Carlson SM, 2001, CHILD DEV, V72, P1032, DOI 10.1111/1467-8624.00333
Clark C, 2002, J CHILD PSYCHOL PSYC, V43, P785, DOI 10.1111/1469-7610.00084
Clark CAC, 2010, DEV PSYCHOL, V46, P1176, DOI 10.1037/a0019672
Conrad AL, 2010, PEDIATRICS, V125, pE83, DOI 10.1542/peds.2009-0634
Diamantopoulou S, 2007, DEV NEUROPSYCHOL, V32, P521
Downie ALS, 2005, CHILD NEUROPSYCHOL, V11, P479, DOI 10.1080/09297040591001085
Durston S, 2006, NEUROPSYCHOLOGIA, V44, P2149, DOI 10.1016/j.neuropsychologia.2005.10.010
Field A, 2013, DISCOVERING STAT USI
Frye RE, 2009, DEV NEUROPSYCHOL, V34, P254, DOI 10.1080/87565640902805727
Garon N, 2008, PSYCHOL BULL, V134, P31, DOI 10.1037/0033-2909.134.1.31
Gathercole SE, 2000, BRIT J EDUC PSYCHOL, V70, P177, DOI 10.1348/000709900158047
Gathercole SE, 2005, J CHILD PSYCHOL PSYC, V46, P598, DOI 10.1111/j.1469-7610.2004.00379.x
GERSTADT CL, 1994, COGNITION, V53, P129, DOI 10.1016/0010-0277(94)90068-X
Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504
Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P249, DOI 10.1076/chin.8.4.249.13513
Gioia GA, 2002, BEHAV RATING INVENTO
Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
Hayes AF, 2009, COMMUN MONOGR, V76, P408, DOI 10.1080/03637750903310360
Hayes AF, 2014, BRIT J MATH STAT PSY, V67, P451, DOI 10.1111/bmsp.12028
Johnson S, 2011, PEDIATR RES, V69, p11R, DOI 10.1203/PDR.0b013e318212faa0
Landry SH, 2000, CHILD DEV, V71, P358, DOI 10.1111/1467-8624.00150
Lee K, 2013, CHILD DEV, V84, P1
Lezak M, 2004, NEUROPSYCHOLOGICAL A
Loe IM, 2015, CHILD NEUROPSYCHOL, V21, P331, DOI 10.1080/09297049.2014.906568
Loe IM, 2012, EARLY HUM DEV, V88, P111, DOI 10.1016/j.earlhumdev.2011.07.018
Loe IM, 2011, EARLY HUM DEV, V87, P247, DOI 10.1016/j.earlhumdev.2011.01.023
Lonigan C. J., 2007, TEST PRESCHOOL EARLY
Luna B, 2010, BRAIN COGNITION, V72, P101, DOI 10.1016/j.bandc.2009.08.005
Mahone EM, 2007, CLIN NEUROPSYCHOL, V21, P569, DOI 10.1080/13854040600762724
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
Mulder H, 2010, ARCH DIS CHILD-FETAL, V95, pF267, DOI 10.1136/adc.2009.167965
Mulder H, 2011, BRIT J EDUC PSYCHOL, V81, P147, DOI 10.1348/000709910X505527
Mulder H, 2009, DEV NEUROPSYCHOL, V34, P393, DOI 10.1080/87565640902964524
Nadeau L, 2001, J DEV BEHAV PEDIATR, V22, P1
Payne JM, 2011, CHILD NEUROPSYCHOL, V17, P313, DOI 10.1080/09297049.2010.542746
Preacher KJ, 2011, PSYCHOL METHODS, V16, P93, DOI 10.1037/a0022658
REED MA, 1984, MERRILL PALMER QUART, V30, P131
Roid G. H., 2003, STANFORD BINET INTEL
Rose SA, 2011, DEVELOPMENTAL SCI, V14, P1161, DOI 10.1111/j.1467-7687.2011.01068.x
Samara M, 2008, PEDIATRICS, V122, P562, DOI 10.1542/peds.2007-3231
Scott MN, 2012, J DEV BEHAV PEDIATR, V33, P202, DOI 10.1097/DBP.0b013e3182475287
Silver CH, 2014, CHILD NEUROPSYCHOL, V20, P1, DOI 10.1080/09297049.2012.727793
Sparrow SS, 2005, VINELAND ADAPTIVE BE
St Clair-Thompson HL, 2006, Q J EXP PSYCHOL, V59, P745, DOI 10.1080/17470210500162854
Taylor HG, 2006, J DEV BEHAV PEDIATR, V27, P459, DOI 10.1097/00004703-200612000-00002
Toplak ME, 2009, CHILD NEUROPSYCHOL, V15, P53, DOI 10.1080/09297040802070929
Volpe JJ, 2009, LANCET NEUROL, V8, P110, DOI 10.1016/S1474-4422(08)70294-1
Wahlstedt C, 2008, DEV NEUROPSYCHOL, V33, P160, DOI 10.1080/87565640701884253
Warren SL, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00271
Woodward LJ, 2011, DEV NEUROPSYCHOL, V36, P22, DOI 10.1080/87565641.2011.540530
Zelazo PD, 2006, NAT PROTOC, V1, P297, DOI 10.1038/nprot.2006.46
NR 64
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD JUN
PY 2014
VL 35
IS 5
BP 323
EP 333
PG 11
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA AJ0PL
UT WOS:000337357400003
PM 24906034
ER
PT J
AU Hall, GC
Hill, F
AF Hall, Gillian C.
Hill, Fiona
TI Descriptive investigation of the recording of influenza vaccination
details on The Health Information Network database
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Article
DE pharmacoepidemiology; influenza; vaccination; batch number; primary care
database; validation
ID BELLS-PALSY; RISK; VACCINES; AUTISM; SAFETY
AB BackgroundThe UK primary care databases are used in pharmacoepidemiology studies of vaccination type. We investigated vaccine recording and whether, and how, exposure to specific brands and batches can be identified. MethodsDetails of influenza vaccinations given in the 2010-2011 or 2011-2012 seasons were identified from coded and text fields in The Health Information Network UK primary care database. The proportion of people over 64years of age vaccinated against influenza was compared with published regional rates. Searches for Fluvirin (Novartis Vaccines and Diagnostics GmbH, Marburg, Germany) batch numbers and name identified exposure to this specific vaccine. The recording of any brand name and batch number was described for a sample of 1000 vaccinations across 472 practices. ResultsA total of 767904 influenza vaccinations were identified during the 2010-2011 season and 784518 in 2011-2012. Vaccination rates for people aged over 64years were 75.6%, 80.9%, 78.4% and 71.9% in England, Northern Ireland, Scotland and Wales, respectively (2011-2012 season), compared with published figures of 74.0%, 77.0%, 76.2% and 67.7%. Rates were slightly lower in 2010-2011 in both data sources. A Fluvirin brand was identified for 3.6% of all UK vaccinations but 26.2% of those in Scottish practices. Vaccination brand could be identified for 94.3% of the sample, 93.6% with a batch number. Batch number (98.5%) and brand name (50.3%) were most frequently recorded in an immunisation batch' text field. ConclusionPatients exposed to an influenza vaccine in primary care can be identified from The Health Information Network. Identification of brand or batch number requires a text search. Regional variation in brand of vaccine should be considered when estimating sample size. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Hill, Fiona] Cegedim Strateg Data Med Res Ltd, London, England.
RP Hall, GC (reprint author), Grimsdyke House, London EN5 4ND, England.
EM gillian_hall@gchall.demon.co.uk
CR Armstrong PK, 2011, BMJ OPEN, V1, DOI 10.1136/bmjopen-2010-000016
Begum F, 2012, SEASONAL INFLUENZA V
Bower H, 1999, BRIT MED J, V318, P1643
Burns H, 2011, SEASONAL INFLUENZA V
Campion EW, 2002, NEW ENGL J MED, V347, P1474, DOI 10.1056/NEJMp020125
Davies S, 2010, INFLUENZA IMMUNISATI
Department of Health, 2013, IMM INF DIS DEP HLTH
Directorate of Chief Medical Officer and Public Health, SEAS INFL VACC PROGR
Fombonne E, 2004, BMC PUBLIC HEALTH, V4, DOI 10.1186/1471-2458-4-5
Hall GC, 2012, PHARMACOEPIDEM DR S, V21, P1, DOI 10.1002/pds.2229
Jick H, 2001, BRIT J CLIN PHARMACO, V52, P451, DOI 10.1046/j.0306-5251.2001.?aid?.x
Joint Formulary Committee, 2012, BRIT NAT FORM 63 BRI
Louik C, 2013, PHARMACOEPIDEM DR S, V22, P33, DOI 10.1002/pds.3336
McVernon J, 2003, LANCET, V361, P1521, DOI 10.1016/S0140-6736(03)13171-6
Mutsch M, 2004, NEW ENGL J MED, V350, P896, DOI 10.1056/NEJMoa030595
NHS Centre for Coding and Classification, 1996, READ COD VERS 3
Partinen M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033723
Public Health for England, INFL VACC UPT AM GP
Public Health Wales Vaccine Preventable Disease Programme, 2012, SEAS INFL VACC UPT W
Shah SM, 2012, AGE AGEING, V41, P64, DOI 10.1093/ageing/afr135
Smeeth L, 2004, LANCET, V364, P963, DOI 10.1016/S0140-6736(04)17020-7
Stowe J, 2006, HUM VACCINES, V2, P110
NR 22
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1053-8569
EI 1099-1557
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD JUN
PY 2014
VL 23
IS 6
BP 595
EP 600
DI 10.1002/pds.3515
PG 6
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AJ2YS
UT WOS:000337532000007
PM 24123471
ER
PT J
AU Imai, K
Iida, T
Yamamoto, M
Komatsu, K
Nukui, Y
Yoshizawa, A
AF Imai, Koubun
Iida, Toshiharu
Yamamoto, Maki
Komatsu, Kensuke
Nukui, Yuko
Yoshizawa, Atsuto
TI Psychological and mental health problems in patients with thalidomide
embryopathy in Japan
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE cognitive performance; electroencephalography; Mini-International
Neuropsychiatric Interview; psychological tests; thalidomide embryopathy
AB Aim The aim of the study was to examine the presence of psychological and mental health problems in patients with thalidomide embryopathy in Japan in order to develop and build future support systems. Methods The present study examined the presence/absence of electroencephalographic abnormalities, intellectual/cognitive functions, and mental health problems in 22 participants (nine men, 13 women) with thalidomide embryopathy. Participants completed the electroencephalograph instrument. Participants were also assessed using the Wechsler Adult Intelligence Scale-III; the Autism-Spectrum Quotient; the General Health Questionnaire-28, and the Mini-International Neuropsychiatric Interview. Results The results suggest the following: (i) electroencephalographic abnormality observed in several thalidomide embryopathy participants is unlikely to be the direct result of thalidomide; (ii) the cognitive functions of working memory and processing speed are lower in thalidomide embryopathy patients than in healthy individuals; and (iii) 40.9% of the thalidomide embryopathy participants have possible mental disorders, with more mental problems observed than in healthy individuals. Conclusions Deterioration of mental health in patients with thalidomide embryopathy is indicated. Anxiety, insomnia, and physical symptoms were especially remarkable and may have resulted in restriction of social activities. Therefore, careful examination and active support of patients' psychological and mental problems is essential.
C1 [Imai, Koubun; Iida, Toshiharu; Yamamoto, Maki; Nukui, Yuko] Natl Ctr Global Hlth & Med Hosp, Dept Psychiat, Tokyo 1628655, Japan.
[Komatsu, Kensuke] Natl Ctr Global Hlth & Med Hosp, AIDS Clin Ctr, Tokyo 1628655, Japan.
[Yoshizawa, Atsuto] Natl Ctr Global Hlth & Med Hosp, Dept Gen Internal Med, Tokyo 1628655, Japan.
[Iida, Toshiharu] Yamanashi Eiwa Coll, Dept Humanities, Yamanashi, Japan.
RP Imai, K (reprint author), Natl Ctr Global Hlth & Med Hosp, Dept Psychiat, Shinjyuku Ku, 1-21-1 Toyama, Tokyo 1628655, Japan.
EM mental@hosp.ncgm.go.jp
FU Ministry of Health, Labour and Welfare, Japan
FX This study was funded by a Grant-in-Aid for Research on Regulatory
Science of Pharmaceuticals and Medical Devices from the Ministry of
Health, Labour and Welfare, Japan. The authors report no conflicts of
interest.
CR KANNO O, 1987, JPN J PSYCHIAT NEUR, V41, P197
Nakagawa Y, 1985, MANUAL JAPANESE GEN
Otsubo T, 2000, M I N I BRIEF DIAGNO
Saito T, 1997, JPN J MENT HLTH, V12, P58
Saito T, 2004, JPN J MENT HLTH, V19, P88
Saito T, 1987, THALIDOMIDE EMBRYOPA, P35
STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351
Wakabayashi Akio, 2004, Shinrigaku Kenkyu, V75, P78
Wechsler D., 2006, JAPANESE VERSION TEC
NR 9
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD JUN
PY 2014
VL 68
IS 6
BP 479
EP 486
DI 10.1111/pcn.12152
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AJ3JW
UT WOS:000337563500014
PM 24548169
ER
PT J
AU Rhodes, G
Jeffery, L
Taylor, L
Hayward, WG
Ewing, L
AF Rhodes, Gillian
Jeffery, Linda
Taylor, Libby
Hayward, William G.
Ewing, Louise
TI Individual Differences in Adaptive Coding of Face Identity Are Linked to
Individual Differences in Face Recognition Ability
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE
LA English
DT Article
DE face recognition; face identity aftereffects; face adaptation;
individual differences
ID MEMORY TEST; CHILDREN; PERCEPTION; AUTISM; PROSOPAGNOSIA; ADAPTATION;
SPACE
AB Despite their similarity as visual patterns, we can discriminate and recognize many thousands of faces. This expertise has been linked to 2 coding mechanisms: holistic integration of information across the face and adaptive coding of face identity using norms tuned by experience. Recently, individual differences in face recognition ability have been discovered and linked to differences in holistic coding. Here we show that they are also linked to individual differences in adaptive coding of face identity, measured using face identity aftereffects. Identity aftereffects correlated significantly with several measures of face-selective recognition ability. They also correlated marginally with own-race face recognition ability, suggesting a role for adaptive coding in the well-known other-race effect. More generally, these results highlight the important functional role of adaptive face-coding mechanisms in face expertise, taking us beyond the traditional focus on holistic coding mechanisms.
C1 [Rhodes, Gillian; Jeffery, Linda; Taylor, Libby; Hayward, William G.; Ewing, Louise] Univ Western Australia, ARC Ctr Excellence Cognit & Its Disorders, Sch Psychol, Perth, WA 6009, Australia.
[Hayward, William G.] Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China.
RP Rhodes, G (reprint author), Univ Western Australia, Sch Psychol, 35 Stirling Highway, Crawley, WA 6009, Australia.
EM gillian.rhodes@uwa.edu.au
RI Ewing, Louise/H-9158-2014
FU Australian Research Council Centre of Excellence in Cognition and its
Disorders [CE110001021]; ARC Professorial Fellowship [DP0877379]; ARC
Discovery Outstanding Researcher Award [DP130102300]
FX This research was supported by the Australian Research Council Centre of
Excellence in Cognition and its Disorders (CE110001021), an ARC
Professorial Fellowship to Rhodes (DP0877379) and an ARC Discovery
Outstanding Researcher Award to Rhodes (DP130102300). We thank Christian
Meissner for supplying Caucasian faces used in the old/new recognition
tests, Rachell Barker for assistance with stimulus preparation, Ainsley
Read for assistance with testing, and Mayu Nishimura and Daphne Maurer
for cocreating the Robbers Game used in the Identity Aftereffects task.
Ethical approval was granted by the Human Research Ethics Committee of
the University of Western Australia.
CR Armann R., 2011, J VISION, V11, p[9, 1], DOI 10.1167/11.13.9
Bowles DC, 2009, COGN NEUROPSYCHOL, V26, P423, DOI 10.1080/02643290903343149
Clifford C. W. G., 2005, FITTING MIND WORLD A, DOI [10.1093/acprof:oso/9780198529699.001.0001, DOI 10.1093/ACPROF:OSO/9780198529699.001.0001]
DeGutis J, 2013, COGNITION, V126, P87, DOI 10.1016/j.cognition.2012.09.004
DeGutis J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058253
Dennett HW, 2012, PSYCHOL SCI, V23, P1279, DOI 10.1177/0956797612446350
Duchaine B, 2006, NEUROPSYCHOLOGIA, V44, P576, DOI 10.1016/j.neuropsychologia.2005.07.001
Ewing L, 2013, DEVELOPMENTAL SCI, V16, P116, DOI 10.1111/desc.12007
Farah MJ, 1998, PSYCHOL REV, V105, P482, DOI 10.1037//0033-295X.105.3.482
Fiorentini C, 2012, NEUROPSYCHOLOGIA, V50, P2926, DOI 10.1016/j.neuropsychologia.2012.08.019
Georgeson M, 2004, CURR BIOL, V14, pR751, DOI 10.1016/j.cub.2004.09.011
Jaquet E, 2008, VIS COGN, V16, P734, DOI 10.1080/13506280701350647
Jeffery L, 2011, J EXP PSYCHOL HUMAN, V37, P1824, DOI 10.1037/a0025643
Kendall M. G., 1958, ADV THEORY STAT, V1
Konar Y, 2010, PSYCHOL SCI, V21, P38, DOI 10.1177/0956797609356508
Leopold D. A., 2011, OXFORD HDB FACE PERC, P263
Leopold DA, 2001, NAT NEUROSCI, V4, P89, DOI 10.1038/82947
Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4
McKone E, 2010, P NATL ACAD SCI USA, V107, P4795, DOI 10.1073/pnas.1000567107
McKone E, 2007, TRENDS COGN SCI, V11, P8, DOI 10.1016/j.tics.2006.11.002
Meissner CA, 2001, PSYCHOL PUBLIC POL L, V7, P3, DOI 10.1037//1076-8971.7.1.3
Nishimura M, 2010, NEUROPSYCHOLOGIA, V48, P1828, DOI 10.1016/j.neuropsychologia.2010.03.007
Palermo R, 2011, NEUROPSYCHOLOGIA, V49, P3801, DOI 10.1016/j.neuropsychologia.2011.09.039
Pellicano E, 2013, NEUROPSYCHOLOGIA, V51, P1504, DOI 10.1016/j.neuropsychologia.2013.03.021
Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065
Rhodes G, 2007, VISION RES, V47, P974, DOI 10.1016/j.visres.2006.12.010
Rhodes G, 2009, VISION RES, V49, P2379, DOI 10.1016/j.visres.2009.07.010
Rhodes G, 2006, VISION RES, V46, P2977, DOI 10.1016/j.visres.2006.03.002
Rhodes G, 2010, VISION RES, V50, P963, DOI 10.1016/j.visres.2010.03.003
Rhodes G., 2013, OXFORD HDB COGNITIVE, P46, DOI 10.1093/oxfordhb/9780195376746.013.0004
Rhodes G, 2011, VISION RES, V51, P1811, DOI 10.1016/j.visres.2011.06.008
Richler JJ, 2011, PSYCHOL SCI, V22, P464, DOI 10.1177/0956797611401753
Robbins R., 2011, OXFORD HDB FACE PERC, P149, DOI DOI 10.1093/OXFORDHB/9780199559053.013.0009
Rossion B, 2008, ACTA PSYCHOL, V128, P274, DOI 10.1016/j.actpsy.2008.02.003
Susilo T, 2010, J VISION, V10, DOI 10.1167/10.13.1
Tanaka J. W., 2011, OXFORD HDB FACE PERC, P177, DOI DOI 10.1093/0XF0RDHB/9780199559053.013.0010
Tavashmi R., 2011, BEHAV RES METHODS, V44, P587, DOI DOI 10.3758/S13428-011-0160-2
Tsao DY, 2006, SCIENCE, V311, P670, DOI 10.1126/science.1119983
Wang RS, 2012, PSYCHOL SCI, V23, P169, DOI 10.1177/0956797611420575
Webster MA, 2011, PHILOS T R SOC B, V366, P1702, DOI 10.1098/rstb.2010.0360
Wilhelm O, 2010, J PERS SOC PSYCHOL, V99, P530, DOI 10.1037/a0019972
Wilmer JB, 2010, P NATL ACAD SCI USA, V107, P5238, DOI 10.1073/pnas.0913053107
Wilson HR, 2002, VISION RES, V42, P2909, DOI 10.1016/S0042-6989(02)00362-0
Zhu Q, 2010, CURR BIOL, V20, P137, DOI 10.1016/j.cub.2009.11.067
NR 44
TC 6
Z9 6
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-1523
EI 1939-1277
J9 J EXP PSYCHOL HUMAN
JI J. Exp. Psychol.-Hum. Percept. Perform.
PD JUN
PY 2014
VL 40
IS 3
BP 897
EP 903
DI 10.1037/a0035939
PG 7
WC Psychology; Psychology, Experimental
SC Psychology
GA AI3TP
UT WOS:000336786900001
PM 24684315
ER
PT J
AU Kopec, J
Hillier, A
Frye, A
AF Kopec, Justin
Hillier, Ashleigh
Frye, Alice
TI THE VALENCY OF MUSIC HAS DIFFERENT EFFECTS ON THE EMOTIONAL RESPONSES OF
THOSE WITH AUTISM SPECTRUM DISORDERS AND A COMPARISON GROUP
SO MUSIC PERCEPTION
LA English
DT Article
DE Asperger's syndrome; autism; music perception; valence; emotional
response
ID BASIC EMOTIONS; ALEXITHYMIA; FACES; FELT; CHILDREN; VALIDITY;
DISABILITIES; RECOGNITION; CONVERGENT; ABILITIES
AB EMOTION PERCEPTION DEFICITS ARE COMMONLY observed in individuals with autism spectrum disorders (ASD). Numerous studies have documented deficits in emotional recognition of social stimuli among those with ASD, such as faces and voices, while far fewer have investigated emotional recognition of nonsocial stimuli in this population. In this study, participants with ASD and a comparison group of typically developing (TD) control participants listened to song clips that varied in levels of pleasantness (valence) and arousal. Participants then rated emotions they felt or perceived in the music, using a list of eight emotion words for each song. Results showed that individuals with ASD gave significantly lower ratings of negative emotions in both the felt and perceived categories compared to TD controls, but did not show significant differences in ratings of positive emotions. These findings suggest that deficits in processing emotions in music among those with ASD may be valence specific.
C1 [Kopec, Justin; Hillier, Ashleigh; Frye, Alice] Univ Massachusetts Lowell, Lowell, MA 01854 USA.
RP Hillier, A (reprint author), Univ Massachusetts Lowell, Dept Psychol, 131 Wilder St,Suite 300, Lowell, MA 01854 USA.
EM Ashleigh_Hillier@uml.edu
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
Ali SO, 2010, MUSIC PERCEPT, V27, P177, DOI 10.1525/MP.2010.27.3.177
Allen R, 2009, AUTISM, V13, P21, DOI 10.1177/1362361307098511
Allen R, 2013, J AUTISM DEV DISORD, V43, P432, DOI 10.1007/s10803-012-1587-8
Allen R, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00156
Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013
Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
Caria A, 2011, CEREB CORTEX, V21, P2838, DOI 10.1093/cercor/bhr084
FIDELL L., 2007, EXPT DESIGNS USING A
Gabrielsson A, 2001, MUSIC SCI, V5, P123
Gilliam J., 2001, GILLIAM ASPERGERS DI
Gross TF, 2004, J ABNORM CHILD PSYCH, V32, P469, DOI 10.1023/B:JACP.0000037777.17698.01
Heaton P, 1999, PSYCHOL MED, V29, P1405, DOI 10.1017/S0033291799001221
Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
HOBSON RP, 1989, BRIT J DEV PSYCHOL, V7, P237
Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020
Huron D, 2001, ANN NY ACAD SCI, V930, P43
Iwanaga M, 1996, J MUSIC THER, V33, P219
Kallinen K, 2006, MUSIC SCI, V10, P191, DOI 10.1177/102986490601000203
KAWAKAMI A., 2012, P 12 INT C MUS PERC, P52
Kawakami A, 2013, MUSIC PERCEPT, V30, P407, DOI 10.1525/MP.2013.30.4.407
Lang P. J., 2008, A7 U FLOR
Levitin Daniel, 2006, THIS IS YOUR BRAIN M
Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253
Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
Patel A., 2008, MUSIC LANGUAGE BRAIN
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Quintin EM, 2011, J AUTISM DEV DISORD, V41, P1240, DOI 10.1007/s10803-010-1146-0
Rogers J, 2006, PSYCHOL MED, V36, P1789, DOI 10.1017/S0033291706008853
Schubert E, 2007, J MUSIC THER, V44, P344
SIFNEOS PE, 1973, PSYCHOTHER PSYCHOSOM, V22, P255
Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
Vorst HCM, 2001, PERS INDIV DIFFER, V30, P413, DOI 10.1016/S0191-8869(00)00033-7
Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
NR 41
TC 0
Z9 0
PU UNIV CALIFORNIA PRESS
PI OAKLAND
PA 155 GRAND AVE, SUITE 400, OAKLAND, CA 94612-3758 USA
SN 0730-7829
J9 MUSIC PERCEPT
JI Music Percept.
PD JUN
PY 2014
VL 31
IS 5
BP 436
EP 443
DI 10.1525/MP.2014.31.5.436
PG 8
WC Music; Psychology, Experimental
SC Music; Psychology
GA AI8YM
UT WOS:000337212900003
ER
PT J
AU Reilly, C
Atkinson, P
Das, KB
Chin, RFMC
Aylett, SE
Burch, V
Gillberg, C
Scott, RC
Neville, BGR
AF Reilly, Colin
Atkinson, Patricia
Das, Krishna B.
Chin, Richard F. M. C.
Aylett, Sarah E.
Burch, Victoria
Gillberg, Christopher
Scott, Rod C.
Neville, Brian G. R.
TI Neurobehavioral Comorbidities in Children With Active Epilepsy: A
Population-Based Study
SO PEDIATRICS
LA English
DT Article
DE epilepsy; children; cognition; behavior; screening
ID CHILDHOOD-ONSET EPILEPSY; PEDIATRIC EPILEPSY; PSYCHIATRIC COMORBIDITY;
DISORDERS; OUTCOMES; UPDATE
AB BACKGROUND: In addition to recurrent epileptic seizures, children with epilepsy can have coexisting cognitive and behavioral difficulties but the spectrum and prevalence of such difficulties are uncertain.
METHODS: The Children with Epilepsy in Sussex Schools study is a prospective, community-based study involving school-aged children (5-15 years) with active epilepsy in a defined geographical area in the United Kingdom. Participants underwent comprehensive psychological assessment, including measures of cognition, behavior, and motor functioning. Consensus neurobehavioral diagnoses were made with respect to Diagnostic and Statistical Manual, Fourth Edition-Text Revision (DSM-IV-TR) criteria.
RESULTS: A total of 85 children (74% of eligible population) were enrolled; 80% of children with active epilepsy had a DSM-IV-TR behavioral disorder and/or cognitive impairment (IQ < 85). Intellectual disability (ID) (IQ < 70) (40%), attention-deficit/hyperactivity disorder (ADHD) (33%), and autism spectrum disorder (ASD) (21%) were the most common neurobehavioral diagnoses. Of those who met criteria for a DSM-IV-TR behavioral disorder, only one-third had previously been diagnosed. Logistic regression revealed that seizures in the first 24 months compared with first seizures at 24 to 60 or 61+ months (odds ratio [OR] 13, 95% confidence interval 2.2-76.9; OR 21.3, 3.2-148.9) and polytherapy (OR 7.7, 1.6-36.3) were independently associated with ID and the presence of ID was associated with a diagnosis of ASD (OR 14.1, 2.3-87.1) after Bonferroni adjustment. Epilepsy-related factors did not independently predict the presence of behavioral disorders.
CONCLUSIONS: Screening for neurobehavioral comorbidities should be an integral part of management in children with "active" epilepsy. There is a need for research to identify neurobiological mechanisms underpinning neurobehavioral impairments and studies to evaluate possible treatments.
C1 [Reilly, Colin; Das, Krishna B.; Burch, Victoria; Neville, Brian G. R.] Young Epilepsy, Res Dept, Surrey RH7 6PW, England.
[Atkinson, Patricia] Crawley Hosp, Child Dev Ctr, Crawley, W Sussex, England.
[Das, Krishna B.; Aylett, Sarah E.; Gillberg, Christopher; Scott, Rod C.; Neville, Brian G. R.] UCL, Inst Child Hlth, Neurosci Unit, London, England.
[Das, Krishna B.; Aylett, Sarah E.; Scott, Rod C.] Great Ormond St Hosp Sick Children, London, England.
[Chin, Richard F. M. C.] Univ Edinburgh, Edinburgh Neurosci, Muir Maxwell Epilepsy Ctr, Edinburgh, Midlothian, Scotland.
[Gillberg, Christopher] Univ Gothenburg, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
[Scott, Rod C.] Univ Vermont, Coll Med, Burlington, VT USA.
RP Reilly, C (reprint author), Young Epilepsy, Res Dept, Surrey RH7 6PW, England.
EM creilly@youngepilepsy.org.uk
FU Esmee Fairbairn Foundation; Great Ormond Street Hospital Children's
Charity
FX The Children with Epilepsy in Sussex Schools study was funded by the
Esmee Fairbairn Foundation and an anonymous donor to Young Epilepsy.
Professor Scott is supported by the Great Ormond Street Hospital
Children's Charity.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Austin JK, 2007, EPILEPSIA, V48, P1639, DOI 10.1111/j.1528-1167.2007.01154.x
Berg AT, 2008, EPILEPSIA, V49, P608, DOI 10.1111/j.1528-1167.2007.01461.x
Berg AT, 2011, EPILEPSY BEHAV, V20, P550, DOI 10.1016/j.yebeh.2010.12.038
Berg AT, 2010, EPILEPSIA, V51, P676, DOI 10.1111/j.1528-1167.2010.02522.x
Blocher JB, 2013, EPILEPSY BEHAV, V27, P70, DOI 10.1016/j.yebeh.2012.12.014
Camfield CS, 1996, EPILEPSIA, V37, P19, DOI 10.1111/j.1528-1157.1996.tb00506.x
Canitano R, 2007, EUR CHILD ADOLES PSY, V16, P61, DOI 10.1007/s00787-006-0563-2
Chin RFM, 2011, EPILEPSIA, V52, P1513, DOI 10.1111/j.1528-1167.2011.03170.x
Davies S, 2003, DEV MED CHILD NEUROL, V45, P292, DOI 10.1017/S0012162203000550
Elger CE, 2004, LANCET NEUROL, V3, P663, DOI 10.1016/S1474-4422(04)00906-8
Geerts A, 2011, EPILEPSIA, V52, P2192, DOI 10.1111/j.1528-1167.2011.03294.x
Gonzalez-Heydrich J, 2010, EPILEPSY BEHAV, V18, P229, DOI 10.1016/j.yebeh.2010.02.022
Hamiwka L, 2011, EPILEPSIA, V52, P870, DOI 10.1111/j.1528-1167.2011.03074.x
Helmstaedter C., 2011, NEUROPSYCHOLOGY CARE
Hermann B, 2008, LANCET NEUROL, V7, P151, DOI 10.1016/S1474-4422(08)70018-8
Hoie B, 2005, SEIZURE-EUR J EPILEP, V14, P223, DOI 10.1016/j.seizure.2004.10.006
Jensen FE, 2011, EPILEPSIA, V52, P1, DOI 10.1111/j.1528-1167.2010.02904.x
Jones JE, 2007, DEV MED CHILD NEUROL, V49, P493
Kadesjo B, 1999, J AM ACAD CHILD PSY, V38, P820, DOI 10.1097/00004583-199907000-00011
Lin JJ, 2012, LANCET, V380, P1180, DOI 10.1016/S0140-6736(12)61455-X
Martinos MM, 2013, EPILEPSIA, V54, P1012, DOI 10.1111/epi.12136
Martinovic Z, 2006, EPILEPSY BEHAV, V9, P619, DOI 10.1016/j.yebeh.2006.08.017
Ott D, 2003, EPILEPSIA, V44, P591, DOI 10.1046/j.1528-1157.2003.25002.x
Plioplys S, 2007, J AM ACAD CHILD PSY, V46, P1389, DOI 10.1097/chi.0b013e31815597fc
Rai D, 2012, EPILEPSIA, V53, P1095, DOI 10.1111/j.1528-1167.2012.03500.x
Rantanen K, 2011, EPILEPSIA, V52, P1499, DOI 10.1111/j.1528-1167.2011.03092.x
Rodenburg R, 2006, EPILEPSIA, V47, P601, DOI 10.1111/j.1528-1167.2006.00475.x
Russ SA, 2012, PEDIATRICS, V129, P256, DOI 10.1542/peds.2010-1371
Shinnar S, 2002, J CHILD NEUROL, V17, pS4, DOI 10.1177/08830738020170010201
NR 30
TC 14
Z9 14
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2014
VL 133
IS 6
BP E1586
EP E1593
DI 10.1542/peds.2013-3787
PG 8
WC Pediatrics
SC Pediatrics
GA AI8MY
UT WOS:000337172600014
PM 24864167
ER
PT J
AU Sukenik-Halevy, R
Reches, A
Bar-Shira, A
Simchoni, S
Goldstein, M
Orr-Ortreger, A
Yaron, Y
Ben-Shachar, S
AF Sukenik-Halevy, Rivka
Reches, Adi
Bar-Shira, Anat
Simchoni, Sharon
Goldstein, Myriam
Orr-Ortreger, Avi
Yaron, Yuval
Ben-Shachar, Shay
TI Microscopic chromosome Xp distal deletions - a challenging issue in
prenatal genetic counseling
SO PRENATAL DIAGNOSIS
LA English
DT Article
ID CYTOGENETIC ANALYSIS; FEMALES; PHENOTYPE; AUTISM; SHOX
AB ObjectiveA prenatal diagnosis of chromosome X short arm deletions may present a challenge in prenatal genetic counseling. We present clinical and molecular data of carriers of Xp distal deletions. MethodsWe assessed prenatal and postnatal phenotypes of individuals from three families with large Xp distal deletions and from a fourth family with a small Xp distal deletion. The work-up included karyotyping, chromosomal microarray analysis, and assessment of the X inactivation pattern. ResultsFive out of eight women with large deletions had a short stature (<3rd percentile). Subjects from one family had developmental and emotional problems. All female carriers with small deletions had markedly short stature, whereas the men had mildly short stature. Chromosomal microarray analysis revealed 11.7-19.3Mb deletions in three families and a small similar to 1Mb deletion in the fourth. The pseudoautosomal region 1 of the X chromosome was deleted in two families with large deletions. X inactivation was skewed in all tested cases with large deletions. ConclusionXp distal deletions are mainly associated with short stature. Skewing of the abnormal X chromosome may attenuate the phenotype in cases with large deletions. We suggest that prenatal evaluation in such cases should include sonographic follow-up and assessment of the X inactivation pattern. (c) 2014 John Wiley & Sons, Ltd.
C1 [Sukenik-Halevy, Rivka; Reches, Adi; Bar-Shira, Anat; Simchoni, Sharon; Goldstein, Myriam; Orr-Ortreger, Avi; Yaron, Yuval; Ben-Shachar, Shay] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Genet Inst, IL-69978 Tel Aviv, Israel.
[Sukenik-Halevy, Rivka; Reches, Adi; Bar-Shira, Anat; Simchoni, Sharon; Goldstein, Myriam; Orr-Ortreger, Avi; Yaron, Yuval; Ben-Shachar, Shay] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Prenatal Genet Diag Unit, IL-69978 Tel Aviv, Israel.
[Orr-Ortreger, Avi; Yaron, Yuval] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
RP Ben-Shachar, S (reprint author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Genet Inst, IL-69978 Tel Aviv, Israel.
EM shayb@tlvmc.gov.il
CR Adachi M, 2000, HUM GENET, V106, P306, DOI 10.1007/s004390051042
Benito-Sanz S, 2005, AM J HUM GENET, V77, P533, DOI 10.1086/449313
Carrel L, 2005, NATURE, V434, P400, DOI 10.1038/nature03479
Cho SY, 2012, AM J MED GENET A, V158A, P1462, DOI 10.1002/ajmg.a.35357
Chocholska S, 2006, AM J MED GENET A, V140A, P604, DOI 10.1002/ajmg.a.31145
Lachlan KL, 2006, HUM GENET, V118, P640, DOI 10.1007/s00439-005-0081-1
Ogata T, 2001, J CLIN ENDOCR METAB, V86, P5498, DOI 10.1210/jc.86.11.5498
Orstavik KH, 2009, HUM GENET, V126, P363, DOI 10.1007/s00439-009-0670-5
Rosilio M, 2012, J CLIN ENDOCR METAB, V97, pE1257, DOI 10.1210/jc.2011-3460
Shinawi M, 2009, AM J MED GENET A, V149A, P1138, DOI 10.1002/ajmg.a.32833
Sybert VP, 2004, NEW ENGL J MED, V351, P1227, DOI 10.1056/NEJMra030360
Thomas NS, 1999, HUM GENET, V104, P43, DOI 10.1007/s004390050908
Wandstrat AE, 2000, AM J MED GENET, V94, P163, DOI 10.1002/1096-8628(20000911)94:2<163::AID-AJMG9>3.0.CO;2-U
NR 13
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0197-3851
EI 1097-0223
J9 PRENATAL DIAG
JI Prenat. Diagn.
PD JUN
PY 2014
VL 34
IS 6
BP 592
EP 597
DI 10.1002/pd.4354
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA AJ3UG
UT WOS:000337592500014
PM 24609917
ER
PT J
AU Farrelly, LA
Dicker, P
Wynne, K
English, J
Cagney, G
Focking, M
Cotter, DR
AF Farrelly, Lorna A.
Dicker, Patrick
Wynne, Kieran
English, Jane
Cagney, Gerard
Foecking, Melanie
Cotter, David R.
TI Adolescent Risperidone treatment alters protein expression associated
with protein trafficking and cellular metabolism in the adult rat
prefrontal cortex
SO PROTEOMICS
LA English
DT Article
DE Antipsychotics; Biomedicine; LC-MS/MS; Prefrontal cortex; Risperidone
ID ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIA-PATIENTS; WORKING-MEMORY;
FRONTAL-CORTEX; BRAIN; PHARMACOKINETICS; DYSFUNCTION; MECHANISM;
PSYCHOSIS; DRUGS
AB The prefrontal cortex (PFC) is associated with mental health illnesses including schizophrenia, depression, bipolar disorder, and autism spectrum disorders. It richly expresses neuroreceptors which are the target for antipsychotics. However, as the precise mechanism of action of antipsychotic medications is not known, proteomic studies of the effects of antipsychotic drugs on the brain are warranted. In the current study, we aimed to characterize protein expression in the adult rodent PFC (n = 5 per group) following low-dose treatment with Risperidone or saline in adolescence (postnatal days 34-47). The PFC was examined by triplicate 1 h runs of label-free LC-MS/MS. The raw mass spectral data were analyzed with the MaxQuant (TM) software. Statistical analysis was carried out using SAS (R) Version 9.1. Pathway and functional analysis was performed with Ingenuity Pathway Analysis and in the Database for Annotation, Visualization and Integrated Discovery (DAVID), respectively, the most implicated pathways were found to be related to mitochondrial function, protein trafficking, and the cytoskeleton. This report adds to the current repertoire of data available concerning the effects of antipsychotic drugs on the brain and sheds light on their biological mechanisms. The MS data have been deposited with the ProteomeXchange Consortium with dataset identifier PXD000480.
C1 [Farrelly, Lorna A.; English, Jane; Foecking, Melanie; Cotter, David R.] Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Educ & Res Ctr, Dublin 9, Ireland.
[Dicker, Patrick] Royal Coll Surgeons Ireland, Dept Epidemiol & Publ Hlth, Dublin 2, Ireland.
[Wynne, Kieran; Cagney, Gerard] Univ Coll Dublin, Sch Biomol & Biomed Res, Conway Inst, Dublin 2, Ireland.
RP Focking, M (reprint author), Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Educ & Res Ctr, Dublin 9, Ireland.
EM mfocking@rcsi.ie
FU Science Foundation Ireland [RFP1304]
FX Animal tissue was provided by Professor Ina Weiner in the School of
Psychological Sciences in the University of Tel Aviv. We thank the staff
of the Mass Spectrometry Core Unit in the Conway Institute in the
University College of Dublin for technical assistance. This work was
supported by Science Foundation Ireland (RFP1304 to D.R.C.).
CR Ahmed EU, 2012, NEUROCHEM RES, V37, P1649, DOI 10.1007/s11064-012-0768-3
Aravagiri M, 2002, PSYCHOPHARMACOLOGY, V159, P424, DOI 10.1007/s00213-001-0933-x
Arnt J, 1998, NEUROPSYCHOPHARMACOL, V18, P63, DOI 10.1016/S0893-133X(97)00112-7
BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243
Blakemore SJ, 2006, J CHILD PSYCHOL PSYC, V47, P296, DOI 10.1111/j.1469-7610.2006.01611.x
Bozikas VP, 2006, COMPR PSYCHIAT, V47, P136, DOI 10.1016/j.comppsych.2005.05.002
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1006/abio.1976.9999
Breton Florence, 2011, Neuropsychologia, V49, P203, DOI 10.1016/j.neuropsychologia.2010.11.019
Cannon TD, 2005, ARCH GEN PSYCHIAT, V62, P1071, DOI 10.1001/archpsyc.62.10.1071
Chan MK, 2011, MOL PSYCHIATR, V16, P1189, DOI 10.1038/mp.2010.100
Cox J, 2011, J PROTEOME RES, V10, P1794, DOI 10.1021/pr101065j
Davidson RJ, 2002, BIOL PSYCHIAT, V51, P68, DOI 10.1016/S0006-3223(01)01328-2
English JA, 2011, BIOL PSYCHIAT, V69, P163, DOI 10.1016/j.biopsych.2010.06.031
Goldstein RZ, 2002, AM J PSYCHIAT, V159, P1642, DOI 10.1176/appi.ajp.159.10.1642
Herberth M, 2011, MOL PSYCHIATR, V16, P848, DOI 10.1038/mp.2010.71
HEYKANTS J, 1994, J CLIN PSYCHIAT, V55, P13
Holmes E, 2006, PLOS MED, V3, P1420, DOI 10.1371/journal.pmed.0030327
Horacek J, 2006, CNS DRUGS, V20, P389, DOI 10.2165/00023210-200620050-00004
Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
Larsen TK, 2011, PSYCHOL MED, V41, P1461, DOI 10.1017/S0033291710002023
Lewis DA, 1997, NEUROPSYCHOPHARMACOL, V16, P385, DOI 10.1016/S0893-133X(96)00277-1
Luber CA, 2010, IMMUNITY, V32, P279, DOI 10.1016/j.immuni.2010.01.013
Ma D, 2009, J PROTEOME RES, V8, P3284, DOI 10.1021/pr800983p
Miyamoto S, 2005, MOL PSYCHIATR, V10, P79, DOI 10.1038/sj.mp.4001556
Newcomer JW, 2005, CNS DRUGS, V19, P1
Perlstein WM, 2001, AM J PSYCHIAT, V158, P1105, DOI 10.1176/appi.ajp.158.7.1105
Piontkewitz Y, 2012, BRAIN BEHAV IMMUN, V26, P353, DOI 10.1016/j.bbi.2011.11.004
Piontkewitz Y, 2011, SCHIZOPHRENIA BULL, V37, P1257, DOI 10.1093/schbul/sbq040
Rajkowska G, 2001, BIOL PSYCHIAT, V49, P741, DOI 10.1016/S0006-3223(01)01080-0
Richtand NM, 2006, NEUROPSYCHOPHARMACOL, V31, P77, DOI 10.1038/sj.npp.1300791
Schubert KO, 2012, MOL PSYCHIATR, V17, P669, DOI 10.1038/mp.2011.123
Seeman P, 2002, CAN J PSYCHIAT, V47, P27
Telford JE, 2012, J PROTEOME RES, V11, P3743, DOI 10.1021/pr300218h
VANBEIJSTERVELDT LEC, 1994, PSYCHOPHARMACOLOGY, V114, P53
Vizcaino JA, 2013, NUCLEIC ACIDS RES, V41, pD1063, DOI 10.1093/nar/gks1262
Waanders LF, 2009, P NATL ACAD SCI USA, V106, P18902, DOI 10.1073/pnas.0908351106
WEINBERGER DR, 1986, ARCH GEN PSYCHIAT, V43, P114
Yung AR, 1996, SCHIZOPHRENIA BULL, V22, P283
NR 38
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD JUN
PY 2014
VL 14
IS 12
BP 1574
EP 1578
DI 10.1002/pmic.201300466
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AJ4BX
UT WOS:000337616100014
PM 24733778
ER
PT J
AU Bolte, S
Willfors, C
Berggren, S
Norberg, J
Poltrago, L
Mevel, K
Coco, C
Fransson, P
Borg, J
Sitnikov, R
Toro, R
Tammimies, K
Anderlid, BM
Nordgren, A
Falk, A
Meyer, U
Kere, J
Landen, M
Dalman, C
Ronald, A
Anckarsater, H
Lichtenstein, P
AF Bolte, Sven
Willfors, Charlotte
Berggren, Steve
Norberg, Joakim
Poltrago, Lina
Mevel, Katell
Coco, Christina
Fransson, Peter
Borg, Jacqueline
Sitnikov, Rouslan
Toro, Roberto
Tammimies, Kristiina
Anderlid, Britt-Marie
Nordgren, Ann
Falk, Anna
Meyer, Urs
Kere, Juha
Landen, Mikael
Dalman, Christina
Ronald, Angelica
Anckarsater, Henrik
Lichtenstein, Paul
TI The Roots of Autism and ADHD Twin Study in Sweden (RATSS)
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE psychiatry; etiology; brain; treatment; intervention; drugs
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; MONOZYGOTIC
TWINS; GENERAL-POPULATION; GENETIC INFLUENCES; LONGITUDINAL TWIN;
DISCORDANT; TRAITS
AB Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous system's maturation and a variety of higher cognitive skills is presumed. Only limited research of rather small sample size and narrow scope has been conducted in neurodevelopmental disorders using a twin-differences design. The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environment-phenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders. This article describes the design, recruitment, data collection, measures, collected pairs' characteristics, as well as ongoing and planned analyses in RATSS. Potential gains of the study comprise the identification of environmentally mediated biomarkers, the emergence of candidates for drug development, translational modeling, and new leads for prevention of incapacitating outcomes.
C1 [Bolte, Sven; Willfors, Charlotte; Berggren, Steve; Norberg, Joakim; Poltrago, Lina; Mevel, Katell; Coco, Christina; Borg, Jacqueline; Tammimies, Kristiina] Karolinska Inst, Pediat Neuropsychiat Unit, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, SE-11330 Stockholm, Sweden.
[Bolte, Sven; Berggren, Steve; Coco, Christina] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden.
[Poltrago, Lina] PRIMA Barn & Vuxenpsykiatri, Stockholm, Sweden.
[Mevel, Katell] CNRS, Lab Psychol Child Dev & Educ, U3521, Paris, France.
[Mevel, Katell] Paris Descartes Univ, Paris, France.
[Mevel, Katell] Sorbonne Paris Cite, Paris, France.
[Fransson, Peter; Borg, Jacqueline] Karolinska Inst, Dept Clin Neurosci, SE-11330 Stockholm, Sweden.
[Sitnikov, Rouslan] Karolinska Univ Hosp, Neuroradiol Clin, MRI Res Ctr, Stockholm, Sweden.
[Toro, Roberto] Inst Pasteur, Paris, France.
[Anderlid, Britt-Marie; Nordgren, Ann] Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden.
[Anderlid, Britt-Marie; Nordgren, Ann] Karolinska Inst, Dept Mol Med & Surg, SE-11330 Stockholm, Sweden.
[Falk, Anna] Karolinska Inst, Dept Neurosci, SE-11330 Stockholm, Sweden.
[Meyer, Urs] Swiss Fed Inst Technol, Physiol & Behav Lab, Zurich, Switzerland.
[Kere, Juha] Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
[Landen, Mikael] Sahlgrens Acad, Sect Psychiat & Neurochem, Gothenburg, Sweden.
[Dalman, Christina] Karolinska Inst, Dept Publ Hlth Sci, SE-11330 Stockholm, Sweden.
[Ronald, Angelica] Univ London, Dept Psychol Sci, Ctr Brain & Cognit Dev, London, England.
[Anckarsater, Henrik] Univ Gothenburg, Gothenburg, Sweden.
[Landen, Mikael; Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-11330 Stockholm, Sweden.
RP Bolte, S (reprint author), Karolinska Inst, CAP Res Ctr, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders,Pediat Neuropsychiat Unit, Gavlegatan 22 Entre B,Floor 8, SE-11330 Stockholm, Sweden.
EM sven.bolte@ki.se
RI Ronald, Angelica/C-7812-2009; Fransson, Peter/M-5679-2014
OI Ronald, Angelica/0000-0002-9576-2176; Fransson,
Peter/0000-0002-1305-9875
FU Swedish Research Council; FAS; FORMAS; VINNOVA (a cross-disciplinary
research program concerning children's and youth's mental health)
[259-2012-24]; Innovative Medicines Initiative Joint Undertaking
[115300]; European Union [FP7/2007-2013]; EFPIA; Stockholm County
Council; Sallskapet Barnavard; Swedish Order of Freemasons Grand Loge
Stockholm; Stiftelsen Sunnerdahls Handikappfond; Hjarnfonden; Autism and
Asperger Society Stockholm; Tore Nilssons Stiftelsen; Jeanssons
Stiftelse; Magnus Bergvalls Stiftelse; PRIMA Barn- och Vuxenpsykiatri
FX We greatly acknowledge Kerstin Andersson, Elodie Cauvet, Ann-Charlotte
Engstrom, Anna Lange Nilsson, Martin Hammar, and Anna Rade for data
collection in RATSS. Furthermore, we sincerely thank all twins and their
relatives who participate in RATSS. The RATSS project is supported by
the Swedish Research Council; the Swedish Research Council in
partnership with FAS, FORMAS, and VINNOVA (a cross-disciplinary research
program concerning children's and youth's mental health, grant no.
259-2012-24); Innovative Medicines Initiative Joint Undertaking (under
grant agreement no. 115300), resources of which are composed of
financial contribution from the European Union's Seventh Framework
Programme (grant no. FP7/2007-2013) and EFPIA companies' in kind
contribution; Stockholm County Council, Sallskapet Barnavard, The
Swedish Order of Freemasons Grand Loge Stockholm, Stiftelsen Sunnerdahls
Handikappfond, Hjarnfonden, Autism and Asperger Society Stockholm, Tore
Nilssons Stiftelsen, Jeanssons Stiftelse, Magnus Bergvalls Stiftelse,
and PRIMA Barn- och Vuxenpsykiatri.
CR Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
Angold A, 1999, J CHILD PSYCHOL PSYC, V40, P57, DOI 10.1017/S0021963098003448
APA, 2013, DSM 5
Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x
Castellanos FX, 2003, AM J PSYCHIAT, V160, P1693, DOI 10.1176/appi.ajp.160.9.1693
Caylak E, 2012, AM J MED GENET B, V159B, P613, DOI 10.1002/ajmg.b.32077
Chang Z, 2013, JAMA PSYCHIAT, V70, P311, DOI 10.1001/jamapsychiatry.2013.287
Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
Christian K. C., 2012, FRONT BIOL, V7, P179
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
De Angelis M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076993
DeVito TJ, 2007, BIOL PSYCHIAT, V61, P465, DOI 10.1016/j.biopsych.2006.07.022
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Durston S, 2008, DEV PSYCHOPATHOL, V20, P1133, DOI 10.1017/S0954579408000539
Dziobek I, 2011, Z KINDER JUG-PSYCH, V39, P79, DOI 10.1024/1422-4917/a000094
Ecker C, 2013, MOL PSYCHIATR, V18, P435, DOI 10.1038/mp.2012.102
Falk A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029597
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Froehlich TE, 2011, CURR PSYCHIAT REP, V13, P333, DOI 10.1007/s11920-011-0221-3
Froehlich TE, 2007, ARCH PEDIAT ADOL MED, V161, P857, DOI 10.1001/archpedi.161.9.857
Geraghty M. E., 2010, ICAN: Infant, Child & Adolescent Nutrition, V2, P120, DOI 10.1177/1941406410366848
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Grafodatskaya D, 2010, J AM ACAD CHILD PSY, V49, P794, DOI 10.1016/j.jaac.2010.05.005
Groen-Blokhuis MM, 2011, J AM ACAD CHILD PSY, V50, P1247, DOI 10.1016/j.jaac.2011.09.007
Hallmayer J, 2002, AM J HUM GENET, V71, P941, DOI 10.1086/342990
Hannelius U, 2007, TWIN RES HUM GENET, V10, P604, DOI 10.1375/twin.10.4.604
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Heiser P, 2004, NEUROSCI BIOBEHAV R, V28, P625, DOI 10.1016/j.neubiorev.2004.09.010
Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
Holtta M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042555
Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
Idring S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041280
Jagatha B, 2009, BIOCHEM BIOPH RES CO, V380, P230, DOI 10.1016/j.bbrc.2009.01.038
Jung C. R., 2013, PLOS ONE, V25
Kates WR, 2009, AUTISM RES, V2, P267, DOI 10.1002/aur.98
Kates WR, 2004, AM J PSYCHIAT, V161, P539, DOI 10.1176/appi.ajp.161.3.539
Kates WR, 1998, ANN NEUROL, V43, P782, DOI 10.1002/ana.410430613
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Konrad K, 2010, HUM BRAIN MAPP, V31, P904, DOI 10.1002/hbm.21058
Kral TVE, 2013, J PEDIATR NURS, V28, P548, DOI 10.1016/j.pedn.2013.01.008
Kroksveen AC, 2011, J PROTEOMICS, V74, P371, DOI 10.1016/j.jprot.2010.11.010
Larsson H, 2012, J CHILD PSYCHOL PSYC, V53, P73, DOI 10.1111/j.1469-7610.2011.02467.x
Lehn H, 2007, J AM ACAD CHILD PSY, V46, P83, DOI 10.1097/01.chi.0000242244.00174.d9
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
Martin N, 1997, NAT GENET, V17, P387, DOI 10.1038/ng1297-387
Mayer E. A., 2012, NAT REV NEUROSCI, V12, P453
Mitchell SR, 2009, AM J PSYCHIAT, V166, P917, DOI 10.1176/appi.ajp.2009.08101538
Moreno-De-Luca A, 2013, LANCET NEUROL, V12, P406, DOI 10.1016/S1474-4422(13)70011-5
Normand S, 2012, J ABNORM CHILD PSYCH, V40, P555, DOI 10.1007/s10802-011-9584-5
Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x
Park IH, 2008, CELL, V134, P877, DOI 10.1016/j.cell.2008.07.041
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
Pastor P, 2009, CALCULATIONS NATL HL
Pearsall-Jones J. G., 2008, Journal of Pediatric Neurology, V6, P209
Pearsall-Jones JG, 2009, TWIN RES HUM GENET, V12, P381, DOI 10.1375/twin.12.4.381
Perlis RH, 2011, MOL PSYCHIATR, V16, P1076, DOI 10.1038/mp.2011.63
Persico AM, 2013, BEHAV BRAIN RES, V251, P95, DOI 10.1016/j.bbr.2013.06.012
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
Regier DA, 2009, AM J PSYCHIAT, V166, P645, DOI 10.1176/appi.ajp.2009.09020279
Reichelt KL, 2009, ANN CLIN PSYCHIATRY, V21, P205
Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
Ronald A, 2010, CHILD DEV, V81, P166, DOI 10.1111/j.1467-8624.2009.01387.x
Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
Ronald A, 2011, MOL PSYCHIATR, V16, P1039, DOI 10.1038/mp.2010.82
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
Senju A, 2013, BRAIN DEV-JPN, V35, P96, DOI 10.1016/j.braindev.2012.08.002
Sharp WS, 2003, J AM ACAD CHILD PSY, V42, P93, DOI 10.1097/01.CHI.0000024903.60748.F4
Shokouhi M, 2012, AUTISM RES, V5, P245, DOI 10.1002/aur.1232
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Smith AK, 2009, CURR PSYCHIAT REP, V11, P143
Sonuga-Barke EJS, 2010, J AM ACAD CHILD PSY, V49, P345, DOI 10.1016/j.jaac.2009.12.018
Sporns O, 2005, PLOS COMPUT BIOL, V1, P245, DOI 10.1371/journal.pcbi.0010042
Taylor MJ, 2013, PSYCHOL MED, V43, P1735, DOI 10.1017/S003329171200253X
Tripp G, 2009, NEUROPHARMACOLOGY, V57, P579, DOI 10.1016/j.neuropharm.2009.07.026
van 't Ent D, 2009, NEUROSCIENCE, V164, P16, DOI 10.1016/j.neuroscience.2009.01.056
Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
Wadsworth SJ, 2007, ANN DYSLEXIA, V57, P139, DOI 10.1007/s11881-007-0009-7
Wazana A, 2007, J AM ACAD CHILD PSY, V46, P721, DOI 10.1097/chi.0b013e31804a7f3b
Wong C. C.Y., MOL PSYCHIA IN PRESS
Wood AC, 2010, J AM ACAD CHILD PSY, V49, P874, DOI 10.1016/j.jaac.2010.06.006
NR 88
TC 1
Z9 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD JUN
PY 2014
VL 17
IS 3
BP 164
EP 176
DI 10.1017/thg.2014.12
PG 13
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA AI9NL
UT WOS:000337259200003
PM 24735654
ER
PT J
AU Srivastava, S
Landy-Schmitt, C
Clark, B
Kline, AD
Specht, M
Grados, MA
AF Srivastava, Siddharth
Landy-Schmitt, Colleen
Clark, Bennett
Kline, Antonie D.
Specht, Matt
Grados, Marco A.
TI Autism traits in children and adolescents with Cornelia de Lange
syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE Cornelia de Lange syndrome; autism; behavioral phenotype; repetitive
behaviors; communication; social cognition
ID FRAGILE-X-SYNDROME; SELF-INJURIOUS-BEHAVIOR; TUBEROUS SCLEROSIS COMPLEX;
SPECTRUM DISORDER; DELANGE-SYNDROME; MENTAL-RETARDATION; NIPPED-B;
PHENOTYPE; MUTATIONS; BRAIN
AB Cornelia de Lange syndrome (CdLS) is a cohesinopathy causing delayed growth and limb deficits. Individuals with CdLS have mild to profound intellectual disability and autistic features. This study characterizes the behavioral phenotype of children with CdLS, focusing on autistic features, maladaptive behaviors, and impact of age. Children with CdLS (5-18 years) were administered normed instruments to characterize autism features (Childhood Autism Rating Scale, CARS), maladaptive behaviors (Aberrant Behavior Checklist), and adaptive skills (Vineland Adaptive Behaviors Scales). CdLS features and severity were rated with Diagnostic Criteria for CdLS. Forty-one children with CdLS (23 females, 18 males) were classified as having "no autism" (n = 7; 17.1%), "mild autism" (n = 17; 41.4%), and "severe autism" (n = 17; 41.4%), using CARS scores. Characteristic items were abnormal emotional response, stereotypies, odd object use, rigidity, lack of verbal communication, and low intellectual functioning. Verbal communication deficits and repetitive behaviors were higher compared to sensory, social cognition, and behavior abnormalities (P <= 0.0001). Maladaptive behaviors associated with autism traits were stereotypies (P = 0.003), hyperactivity (P = 0.01), and lethargy (P = 0.03). Activities of daily living were significantly affected; socialization adaptive skills were a relative strength. However, with advancing age, both socialization (P < 0.0001) and communication (P = 0.001) domains declined significantly. CdLS is characterized by autistic features, notably excessive repetitive behaviors and expressive language deficits. While other adaptive skills are impacted, socialization adaptive skills are less affected. Advancing age can worsen communication and socialization deficits relative to neurotypical peers. (c) 2014 Wiley Periodicals, Inc.
C1 [Srivastava, Siddharth] Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD USA.
[Landy-Schmitt, Colleen] PerkinElmer Diagnost Lab Serv, Frederick, MD USA.
[Clark, Bennett] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
[Kline, Antonie D.] Greater Baltimore Med Ctr, Harvey Inst Human Genet, Baltimore, MD USA.
[Specht, Matt; Grados, Marco A.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
RP Grados, MA (reprint author), Johns Hopkins Univ Hosp, Dept Psychiat, Johns Hopkins Sch Med, Bloomberg Childrens Ctr Floor 12, 1800 Orleans St, Baltimore, MD 21287 USA.
EM mjgrados@jhmi.edu
FU CdLS Foundation USA
FX Grant sponsor: CdLS Foundation USA.
CR Aman M., 1986, ABERRANT BEHAV CHECK
AMAN MG, 1987, AM J MENT RETARD, V92, P237
AMAN MG, 1985, AM J MENT DEF, V89, P492
American Psychiatric Association American Psychiatric Association and DSM-5 Task Force, 2013, DIAGN STAT MAN MENT
Oliver C, 2006, AM J MENT RETARD, V111, P184
Basile E, 2007, J INTELL DISABIL RES, V51, P671, DOI 10.1111/j.1365-2788.2007.00977.x
BECK B, 1987, J MENT DEFIC RES, V31, P251
Berney TP, 1999, ARCH DIS CHILD, V81, P333
Bhuiyan ZA, 2006, J MED GENET, V43, P568, DOI 10.1136/jmg.2005.038240
Blair KS, 2010, AM J PSYCHIAT, V167, P1526, DOI 10.1176/appi.ajp.2010.09121797
Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
Bruhl AB, 2011, BRAIN RES, V1378, P72, DOI 10.1016/j.brainres.2010.12.084
BRYSON Y, 1971, AM J MENT DEF, V76, P319
Budimirovic DB, 2006, AM J MED GENET A, V140A, P1814, DOI 10.1002/ajmg.a.31405
Chang S, 2008, NAT CHEM BIOL, V4, P256, DOI 10.1038/nchembio.78
Collis L, 2008, J INTELL DISABIL RES, V52, P207, DOI 10.1111/j.1365-2788.2007.01004.x
Deardorff MA, 2012, NATURE, V489, P313, DOI 10.1038/nature11316
Deardorff MA, 2007, AM J HUM GENET, V80, P485, DOI 10.1086/511888
Dunbar RIM, 2007, SCIENCE, V317, P1344, DOI 10.1126/science.1145463
DYKENS EM, 1989, J AM ACAD CHILD PSY, V28, P422, DOI 10.1097/00004583-198905000-00020
Dykens Elisabeth M, 2006, Downs Syndr Res Pract, V9, P45, DOI 10.3104/reprints.293
Feinstein C, 2007, CHILD ADOL PSYCH CL, V16, P631, DOI 10.1016/j.chc.2007.03.006
GIBSON D, 1966, AM J MENT DEF, V70, P825
GOODBAN MT, 1993, AM J MED GENET, V47, P1059, DOI 10.1002/ajmg.1320470725
Gross C, 2010, J NEUROSCI, V30, P10624, DOI 10.1523/JNEUROSCI.0402-10.2010
Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
Hall SS, 2008, J INTELL DISABIL RES, V52, P458, DOI 10.1111/j.1365-2788.2008.01047.x
Harris JC, 2003, PHYSIOL BEHAV, V79, P525, DOI 10.1016/S0031-9384(03)00158-6
HAWLEY PP, 1985, AM J MED GENET, V20, P453, DOI 10.1002/ajmg.1320200306
Hazlett HC, 2009, J NEURODEV DISORD, V1, P81, DOI 10.1007/s11689-009-9009-8
HODAPP RM, 1990, J AM ACAD CHILD PSY, V29, P214, DOI 10.1097/00004583-199003000-00009
Hoeft F, 2011, ARCH GEN PSYCHIAT, V68, P295, DOI 10.1001/archgenpsychiatry.2010.153
Hyman P, 2002, AM J MENT RETARD, V107, P146, DOI 10.1352/0895-8017(2002)107<0146:SIBSRA>2.0.CO;2
Hyman P., 2001, Journal of Intellectual Disability Research, V45, P326, DOI 10.1046/j.1365-2788.2001.00325.x
JACKSON L, 1993, AM J MED GENET, V47, P940, DOI 10.1002/ajmg.1320470703
Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
JOHNSON HG, 1976, PEDIATR RES, V10, P843, DOI 10.1203/00006450-197610000-00006
Kanner L, 1943, NERV CHILD, V2, P217
KANNER L, 1971, J AUTISM CHILD SCHIZ, V1, P119, DOI 10.1007/BF01537953
Kline AD, 2007, AM J MED GENET A, V143A, P1287, DOI 10.1002/ajmg.a.31757
Kline AD, 2007, AM J MED GENET C, V145C, P248, DOI 10.1002/ajmg.c.30137
KLINE AD, 1993, AM J MED GENET, V47, P1053, DOI 10.1002/ajmg.1320470724
Krantz ID, 2004, NAT GENET, V36, P631, DOI 10.1038/ng1364
Lewis KP, 2006, J COMP PSYCHOL, V120, P31, DOI 10.1037/0735-7036.120.1.31
Luzzani S, 2003, AM J MED GENET A, V119A, P283, DOI 10.1002/ajmg.a.20191
MARAGANORE DM, 1991, MOVEMENT DISORD, V6, P358, DOI 10.1002/mds.870060418
McAllister CJ, 2011, INT J OBESITY, V35, P188, DOI 10.1038/ijo.2010.139
Micali N, 2004, AUTISM, V8, P21, DOI 10.1177/1362361304040636
Moss J, 2013, AJIDD-AM J INTELLECT, V118, P55, DOI 10.1352/1944-7558-118.1.55
Moss J, 2012, J CHILD PSYCHOL PSYC, V53, P883, DOI 10.1111/j.1469-7610.2012.02540.x
Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
Moss J, 2005, J INTELL DISABIL RES, V49, P269, DOI 10.1111/j.1365-2788.2005.00649.x
Moss JF, 2008, AM J MENT RETARD, V113, P278, DOI 10.1352/0895-8017(2008)113[278:POASPI]2.0.CO;2
Musio A, 2006, NAT GENET, V38, P528, DOI 10.1038/ng1779
Muzykewicz DA, 2007, EPILEPSY BEHAV, V11, P506, DOI 10.1016/j.yebeh.2007.07.010
Narayanan U, 2008, J BIOL CHEM, V283, P18478, DOI 10.1074/jbc.C800055200
Neuhaus E, 2010, CLIN PSYCHOL REV, V30, P733, DOI 10.1016/j.cpr.2010.05.007
NYHAN WL, 1972, PEDIATR RES, V6, P1
Oliver C, 2011, J AUTISM DEV DISORD, V41, P1019, DOI 10.1007/s10803-010-1125-5
Oliver C, 2008, BRIT J PSYCHIAT, V193, P466, DOI 10.1192/bjp.bp.107.044370
Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
REISS AL, 1986, SCHIZOPHRENIA BULL, V12, P724
Richards C, 2009, J AUTISM DEV DISORD, V39, P1155, DOI 10.1007/s10803-009-0730-7
Sarimski K, 2002, J COMMUN DISORD, V35, P483, DOI 10.1016/S0021-9924(02)00117-X
Schopler E., 1988, CHILDHOOD AUTISM RAT
Dimitropoulos Anastasia, 2007, Curr Psychiatry Rep, V9, P159
Snow AV, 2011, J AUTISM DEV DISORD, V41, P302, DOI 10.1007/s10803-010-1054-3
Sparrow S, 1984, VINELAND ADAPTIVE BE
Su PJ, 2008, INT J PEDIATR OTORHI, V72, P1751, DOI 10.1016/j.ijporl.2008.05.017
Tonkin ET, 2004, NAT GENET, V36, P636, DOI 10.1038/ng1363
Vrouwe MG, 2007, HUM MOL GENET, V16, P1478, DOI 10.1093/hmg/ddm098
Vuilleumier N, 2002, ACTA NEUROPATHOL, V104, P327, DOI 10.1007/s00401-002-0562-4
Watrin E, 2006, EXP CELL RES, V312, P2687, DOI 10.1016/j.yexcr.2006.06.024
Wong DF, 1996, P NATL ACAD SCI USA, V93, P5539, DOI 10.1073/pnas.93.11.5539
Wulffaert J, 2009, J INTELL DISABIL RES, V53, P604, DOI 10.1111/j.1365-2788.2009.01185.x
Yamaguchi K, 1999, CLIN NEUROPATHOL, V18, P99
Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 77
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2014
VL 164
IS 6
BP 1400
EP 1410
DI 10.1002/ajmg.a.36573
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA AH2BV
UT WOS:000335926600006
PM 24718998
ER
PT J
AU Kuroda, Y
Ohashi, I
Tominaga, M
Saito, T
Nagai, J
Ida, K
Naruto, T
Masuno, M
Kurosawa, K
AF Kuroda, Yukiko
Ohashi, Ikuko
Tominaga, Makiko
Saito, Toshiyuki
Nagai, Jun-ichi
Ida, Kazumi
Naruto, Takuya
Masuno, Mitsuo
Kurosawa, Kenji
TI De novo duplication of 17p13.1-p13.2 in a patient with intellectual
disability and obesity
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE 17p13.1 duplication; TP53; SLC2A4; obesity; GLUT4
ID GENES; MICRODUPLICATION; MICRODELETIONS; ZEBRAFISH; MUTATIONS; FEATURES;
DISEASE; AUTISM; MODEL; P53
AB 17p13.1 Deletion encompassing TP53 has been described as a syndrome characterized by intellectual disability and dysmorphic features. Only one case with a 17p13.1 duplication encompassing TP53 has been reported in a patient with intellectual disability, seizures, obesity, and diabetes mellitus. Here, we present a patient with a 17p13.1 duplication who exhibited obesity and intellectual disability, similar to the previous report. The 9-year-old proposita was referred for the evaluation of intellectual disability and obesity. She also exhibited insulin resistance and liver dysfunction. She had wide palpebral fissures, upturned nostrils, a long mandible, short and slender fingers, and skin hyperpigmentation. Array comparative genomic hybridization (array CGH) detected a 3.2 Mb duplication of 17p13.1-p13.2 encompassing TP53, FXR2, NLGN2, and SLC2A4, which encodes the insulin-responsive glucose transporter 4 (GLUT4) associated with insulin-stimulated glucose uptake in adipocytes and muscle. We suggest that 17p13.1 duplication may represent a clinically recognizable condition characterized partially by a characteristic facial phenotype, developmental delay, and obesity. (c) 2014 Wiley Periodicals, Inc.
C1 [Kuroda, Yukiko; Ohashi, Ikuko; Tominaga, Makiko; Ida, Kazumi; Naruto, Takuya; Kurosawa, Kenji] Kanagawa Childrens Med Ctr, Div Med Genet, Yokohama, Kanagawa 2328555, Japan.
[Saito, Toshiyuki; Nagai, Jun-ichi] Kanagawa Childrens Med Ctr, Dept Clin Lab, Yokohama, Kanagawa 2328555, Japan.
[Masuno, Mitsuo] Kawasaki Univ Med Welf, Genet Counseling Program, Kurashiki, Okayama, Japan.
RP Kurosawa, K (reprint author), Kanagawa Childrens Med Ctr, Div Med Genet, Minami Ku, 2-138-4 Mutsukawa, Yokohama, Kanagawa 2328555, Japan.
EM kkurosawa@kcmc.jp
FU The Ministry of Health, Labour and Welfare of Japan
FX Grant sponsor: The Ministry of Health, Labour and Welfare of Japan.
CR Belligni EF, 2012, EUR J MED GENET, V55, P222, DOI 10.1016/j.ejmg.2012.01.016
Bontekoe CJM, 2002, HUM MOL GENET, V11, P487, DOI 10.1093/hmg/11.5.487
Bretaud S, 2007, J NEUROCHEM, V100, P1626, DOI 10.1111/j.1471-4159.2006.04291.x
Bruno DL, 2010, J MED GENET, V47, P299, DOI 10.1136/jmg.2009.069906
Charron MJ, 1999, J BIOL CHEM, V274, P3253, DOI 10.1074/jbc.274.6.3253
Coutton C, 2012, AM J MED GENET A, V158A, P2564, DOI 10.1002/ajmg.a.35553
Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kohn L, 2007, EUR J HUM GENET, V15, P664, DOI 10.1038/sj.ejhg.5201817
Komoike Y, 2010, J HUM GENET, V55, P155, DOI 10.1038/jhg.2010.1
Krepischi-Santos ACV, 2009, CYTOGENET GENOME RES, V125, P1, DOI 10.1159/000218743
Kurosawa K, 2012, CONGENIT ANOM, V52, P106, DOI 10.1111/j.1741-4520.2011.00326.x
Leandro GS, 2013, INT J MOL SCI, V14, P12380, DOI 10.3390/ijms140612380
Schluth-Bolard C, 2009, AM J MED GENET A, V152A, P1278
Shlien A, 2010, AM J HUM GENET, V87, P631, DOI 10.1016/j.ajhg.2010.10.007
Sohocki MM, 2000, NAT GENET, V24, P79
ULLRICH SJ, 1992, J BIOL CHEM, V267, P15259
Vousden KH, 2009, CELL, V137, P413, DOI 10.1016/j.cell.2009.04.037
NR 19
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2014
VL 164
IS 6
BP 1550
EP 1554
DI 10.1002/ajmg.a.36477
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA AH2BV
UT WOS:000335926600026
PM 24668897
ER
PT J
AU Wilkinson, KM
Mitchell, T
AF Wilkinson, Krista M.
Mitchell, Teresa
TI Eye Tracking Research to Answer Questions about Augmentative and
Alternative Communication Assessment and Intervention
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Eye tracking; Overview; Research; AAC; Developmental disabilities;
Acquired disabilities
ID VISUAL SCENE DISPLAYS; AUTISM SPECTRUM DISORDERS; WILLIAMS-SYNDROME;
INTELLECTUAL DISABILITIES; INATTENTIONAL BLINDNESS; DOWN-SYNDROME;
ATTENTION; INDIVIDUALS; MOVEMENTS; AAC
AB Recently, eye tracking technologies (i.e., technologies that automatically track the point of an individual's gaze while that person views or interacts with a visual image) have become available for research purposes. Based on the sampling of the orientation of the individual's eyes, researchers can quantify which locations within the visual image were fixated (viewed), for how long, and how many times. These automated eye tracking research technologies open up a wealth of avenues for investigating how individuals with developmental or acquired communication disabilities may respond to aided augmentative and alternative communication (AAC) systems. In this paper, we introduce basic terminology and explore some of the special challenges of conducting eye tracking research with populations with disabilities who might use AAC, including challenges of inferring attention from the presence of fixation and challenges related to calibration that may result from participant characteristics, behavioral idiosyncracies, and/or the number of calibration points. We also examine how the technology can be applied to ask well-structured experimental questions that have direct clinical relevance, with a focus on the unique contributions that eye tracking research can provide by (a) allowing evaluation of skills in individuals who are difficult to assess via traditional methods, and (b) facilitating access to information on underlying visual cognitive processes that is not accessible via traditional behavioral measures.
C1 [Wilkinson, Krista M.] Penn State Univ, University Pk, PA 16802 USA.
[Wilkinson, Krista M.; Mitchell, Teresa] Univ Massachusetts, EK Shriver Ctr, Sch Med, Waltham, MA USA.
RP Wilkinson, KM (reprint author), Penn State Univ, 308 Ford Hall, University Pk, PA 16802 USA.
EM kmw22@psu.edu
FU NIH [P01 HD25995]; Hintz Family Endowed Chair in Children's
Communicative Competence at the Pennsylvania State University; National
Institute on Disability and Rehabilitation Research [H133E030018]
FX Many people have contributed to the authors' ever-growing knowledge of
eye tracking, including William Dube and Wilkie Wong. The eye tracking
research activities of both authors have been supported by NIH P01
HD25995. Support for the first author has also been supplied by the
Rehabilitation Engineering Research Center on Communication Enhancement,
a virtual research center that is funded by the National Institute on
Disability and Rehabilitation Research under Grant H133E030018 and from
the Hintz Family Endowed Chair in Children's Communicative Competence at
the Pennsylvania State University.
CR Beatty J., 2000, HDB PSYCHOPHYSIOLOGY, P142
BEATTY J, 1982, PSYCHOL BULL, V91, P276, DOI 10.1037/0033-2909.91.2.276
Beukelman D., 1988, AUGMENTATIVE ALTERNA, V4, P104, DOI 10.1080/07434618812331274687
Beukelman D, 2007, AUGMENTATIVE COMMUNI
Binger C, 2008, AUGMENT ALTERN COMM, V24, P123, DOI 10.1080/07434610701830587
Brady N. C., 2008, SPEECH LANGUAGE DEV, P255
Brady NC, 2014, AUGMENT ALTERN COMM, V30, P147, DOI 10.3109/07434618.2014.904923
Carlin MT, 2003, AM J MENT RETARD, V108, P181, DOI 10.1352/0895-8017(2003)108<0181:DOCINS>2.0.CO;2
Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
Chawarska K, 2003, CHILD DEV, V74, P1108, DOI 10.1111/1467-8624.00595
Dube WV, 2010, J EXP ANAL BEHAV, V94, P297, DOI 10.1901/jeab.2010.94-297
Dube WV, 2014, AUGMENT ALTERN COMM, V30, P172, DOI 10.3109/07434618.2014.904924
Dunn L. M., 2006, PEABODY PICTURE VOCA, V4th
Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
Fletcher-Watson S, 2008, PERCEPTION, V37, P571, DOI 10.1068/p5705
Garrett K. L., 2013, AUGMENTATIVE ALTERNA, P405
Gillespie-Smith K, 2014, AUGMENT ALTERN COMM, V30, P160, DOI 10.3109/07434618.2014.905635
Gliga T, 2009, INFANCY, V14, P550, DOI 10.1080/15250000903144199
Hernandez N., 2008, NEUROPSYCHOLOGY, V12, P12
Heuer S, 2007, APHASIOLOGY, V21, P883, DOI 10.1080/02687030600695194
Holmqvist K., 2011, EYE TRACKING COMPREH
Hornof AJ, 2002, BEHAV RES METH INS C, V34, P592, DOI 10.3758/BF03195487
Iacono T., 2009, AUTISM SPECTRUM DISO
Ivanova MV, 2012, APHASIOLOGY, V26, P556, DOI 10.1080/02687038.2011.618219
Johnson JM, 2006, AUGMENT ALTERN COMM, V22, P85, DOI 10.1080/07434610500483588
Karetekin C., 2007, DEV REV, V27, P283
Kumin Libby, 2006, Downs Syndr Res Pract, V10, P10, DOI 10.3104/reports.301
Manor BR, 2003, J NEUROSCI METH, V128, P85, DOI 10.1016/S0165-0270(03)00151-1
Martin GE, 2009, TOP LANG DISORD, V29, P112
Memmert D, 2006, CONSCIOUS COGN, V15, P620, DOI 10.1016/j.concog.2006.01.001
Mirenda P., 2013, AUGMENTATIVE ALTERNA, V4th
Nystrom M, 2013, BEHAV RES METHODS, V45, P272, DOI 10.3758/s13428-012-0247-4
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
POSNER MI, 1980, Q J EXP PSYCHOL, V32, P3, DOI 10.1080/00335558008248231
POULTON EC, 1962, BRIT J PSYCHOL, V53, P409
Rayner K, 2009, Q J EXP PSYCHOL, V62, P1457, DOI 10.1080/17470210902816461
Riby D, 2009, J INTELL DISABIL RES, V53, P169, DOI 10.1111/j.1365-2788.2008.01142.x
Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z
Romski M. A., 1996, BREAKING SPEECH BARR
Schlosser RW, 2007, J COMMUN DISORD, V40, P225, DOI 10.1016/j.jcomdis.2006.06.008
Schlosser RW, 2006, RES DEV DISABIL, V27, P1, DOI 10.1016/j.ridd.2004.04.004
Simons DJ, 1999, PERCEPTION, V28, P1059, DOI 10.1068/p2952
Smilek D, 2006, BRAIN RES, V1080, P101, DOI 10.1016/j.brainres.2005.12.090
Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027
Thiessen A, 2014, AUGMENT ALTERN COMM, V30, P120, DOI 10.3109/07434618.2014.905798
Thistle J., 2013, SPEECH LANGUAG UNPUB
Wilkinson KM, 2014, J SPEECH LANG HEAR R, V57, P455, DOI 10.1044/2013_JSLHR-L-12-0159
Wilkinson KM, 2011, J SPEECH LANG HEAR R, V54, P1644, DOI 10.1044/1092-4388(2011/10-0098)
Wilkinson KM, 2012, AUGMENT ALTERN COMM, V28, P137, DOI 10.3109/07434618.2012.704522
Wilkinson KM, 2014, AUGMENT ALTERN COMM, V30, P130, DOI 10.3109/07434618.2014.904434
Wolfe J. M., 2004, NATURE REV NEUROSCIE, V5, P1, DOI DOI 10.1038/NM1411
NR 52
TC 5
Z9 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
EI 1477-3848
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD JUN
PY 2014
VL 30
IS 2
BP 106
EP 119
DI 10.3109/07434618.2014.904435
PG 14
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA AI6XL
UT WOS:000337020600002
PM 24758526
ER
PT J
AU Wilkinson, KM
Light, J
AF Wilkinson, Krista M.
Light, Janice
TI Preliminary Study of Gaze Toward Humans in Photographs by Individuals
with Autism, Down Syndrome, or Other Intellectual Disabilities:
Implications for Design of Visual Scene Displays
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Eye-tracking; Intellectual disability; Display design; Gaze patterns;
AAC; Visual scene displays
ID PERVASIVE DEVELOPMENTAL DISORDER; EYE TRACKING RESEARCH; SPECTRUM
DISORDERS; WILLIAMS-SYNDROME; COMMUNICATION DEVELOPMENT; AAC
TECHNOLOGIES; UNITED-STATES; HUMAN-FIGURES; CHILDREN; ATTENTION
AB Visual scene displays (VSDs) are a form of augmentative and alternative communication display in which language concepts are embedded into an image of a naturalistic event. VSDs are based on the theory that language learning occurs through interactions with other people, and recommendations for VSD design have emphasized using images of these events that include humans. However, many VSDs also include other items that could potentially be distracting. We examined gaze fixation in 18 school-aged participants with and without severe intellectual/developmental disabilities (i.e., individuals with typical development, autism, Down syndrome and other intellectual disabilities) while they viewed photographs with human figures of various sizes and locations in the image, appearing alongside other interesting, and potentially distracting items. In all groups, the human figures attracted attention rapidly (within 1.5 seconds). The proportions of each participant's own fixation time spent on the human figures were similar across all groups, as were the proportions of total fixations made to the human figures. Although the findings are preliminary, this initial evidence supports the inclusion of humans in VSD images.
C1 [Wilkinson, Krista M.; Light, Janice] Penn State Univ, University Pk, PA 16802 USA.
[Wilkinson, Krista M.] Univ Massachusetts, Sch Med, EK Shriver Ctr, Worcester, MA USA.
RP Wilkinson, KM (reprint author), Penn State Univ, 308 Ford Hall, University Pk, PA 16802 USA.
EM kmw22@psu.edu
CR American Society of Human Genetics, 2012, SCIENCEDAILY
Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Blackstone S., 2005, AUGMENTATIVE COMMUNI, V1
Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
Bracco F, 2009, COGN PROCESS, V10, P41, DOI 10.1007/s10339-008-0246-7
Braddock B, 2012, AUGMENT ALTERN COMM, V28, P266, DOI 10.3109/07434618.2012.706637
Brady N. C., 2008, COMMUNICATION LANGUA, P255
Brady NC, 2014, AUGMENT ALTERN COMM, V30, P147, DOI 10.3109/07434618.2014.904923
Bruner J. S., 1983, CHILDS TALK LEARNING
Carlin MT, 2003, AM J MENT RETARD, V108, P181, DOI 10.1352/0895-8017(2003)108<0181:DOCINS>2.0.CO;2
Chapman RS, 2003, INT REV RES MENT RET, V27, P1
Charman T, 2004, J AUTISM DEV DISORD, V34, P59, DOI 10.1023/B:JADD.0000018075.77941.60
Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830
Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
Chawarska K, 2003, CHILD DEV, V74, P1108, DOI 10.1111/1467-8624.00595
Crouzet SM, 2010, J VISION, V10, DOI 10.1167/10.4.16
Dietz A., 2006, PERSPECTIVES AUGMENT, V15, P13, DOI 10.1044/aac15.1.13
Drager K., 2009, AUTISM SPECTRUM DISO, P247
Drager KDR, 2003, J SPEECH LANG HEAR R, V46, P298, DOI 10.1044/1092-4388(2003/024)
Drager KDR, 2004, J SPEECH LANG HEAR R, V47, P1133, DOI 10.1044/1092-4388(2004/084)
Dube WV, 2010, J EXP ANAL BEHAV, V94, P297, DOI 10.1901/jeab.2010.94-297
Dube WV, 2014, AUGMENT ALTERN COMM, V30, P172, DOI 10.3109/07434618.2014.904924
Dunn L. M., 2006, PEABODY PICTURE VOCA, V4th
Dykens E. M., 2000, GENETICS MENTAL RETA
Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
Fletcher-Watson S, 2008, PERCEPTION, V37, P571, DOI 10.1068/p5705
Frenck-Mestre C, 2010, AJIDD-AM J INTELLECT, V115, P193, DOI 10.1352/1944-7558-115.3.193
Gillespie-Smith K, 2014, AUGMENT ALTERN COMM, V30, P160, DOI 10.3109/07434618.2014.905635
Gliga T, 2009, INFANCY, V14, P550, DOI 10.1080/15250000903144199
Hux K, 2010, APHASIOLOGY, V24, P643, DOI 10.1080/02687030902869299
Kemner C, 2007, BRAIN COGNITION, V65, P107, DOI 10.1016/j.bandc.2006.05.006
Light J., 2004, AUGMENTATIVE ALTERNA, V20, P63, DOI 10.1080/07434610410001655553
Light J., 2008, SEM ISAAC C MONTR CA
Martin GE, 2009, TOP LANG DISORD, V29, P112
McKelvey ML, 2007, J MED SPEECH-LANG PA, V15, P305
Nelson K., 1986, EVENT KNOWLEDGE STRU
New J, 2007, P NATL ACAD SCI USA, V104, P16598, DOI 10.1073/pnas.0703913104
New JJ, 2010, NEUROPSYCHOLOGIA, V48, P51, DOI 10.1016/j.neuropsychologia.2009.08.008
Olin AR, 2010, AM J SPEECH-LANG PAT, V19, P284, DOI 10.1044/1058-0360(2010/09-0001)
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Rensink RA, 1997, PSYCHOL SCI, V8, P368, DOI 10.1111/j.1467-9280.1997.tb00427.x
Riby D, 2009, J INTELL DISABIL RES, V53, P169, DOI 10.1111/j.1365-2788.2008.01142.x
Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z
Rice K, 2012, J AM ACAD CHILD PSY, V51, P238, DOI 10.1016/j.jaac.2011.12.017
Roberts JE, 2007, MENT RETARD DEV D R, V13, P26, DOI 10.1002/mrdd.20136
Rutter M., 2003, SOCIAL COMMUNICATION
Schlosser RW, 2013, AUGMENT ALTERN COMM, V29, P132, DOI 10.3109/07434618.2013.784928
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shin M, 2009, PEDIATRICS, V124, P1565, DOI 10.1542/peds.2009-0745
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Smilek D, 2006, BRAIN RES, V1080, P101, DOI 10.1016/j.brainres.2005.12.090
Snell ME, 2010, AJIDD-AM J INTELLECT, V115, P364, DOI 10.1352/1944-7558-115-5.364
Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
Tager-Flusberg H., 2007, COGNITION BRAIN BEHA, V11, P491
Thiessen A, 2014, AUGMENT ALTERN COMM, V30, P120, DOI 10.3109/07434618.2014.905798
Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055
van der Geest JN, 2002, J AUTISM DEV DISORD, V32, P69, DOI 10.1023/A:1014832420206
Vygotsky Lev Semyonovitch, 1986, THOUGHT LANGUAGE
Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
Wilkinson K. M., 2004, AUGMENTATIVE ALTERNA, V20, P123, DOI 10.1080/07434610410001699717
Wilkinson KM, 2011, J SPEECH LANG HEAR R, V54, P1644, DOI 10.1044/1092-4388(2011/10-0098)
Wilkinson KM, 2012, AUGMENT ALTERN COMM, V28, P137, DOI 10.3109/07434618.2012.704522
Wilkinson KM, 2014, AUGMENT ALTERN COMM, V30, P106, DOI 10.3109/07434618.2014.904435
Woodhouse J. M., 2005, SYNDROME NEWS UPDATE, V4, P87
NR 67
TC 4
Z9 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
EI 1477-3848
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD JUN
PY 2014
VL 30
IS 2
BP 130
EP 146
DI 10.3109/07434618.2014.904434
PG 17
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA AI6XL
UT WOS:000337020600004
PM 24773517
ER
PT J
AU Brady, NC
Anderson, CJ
Hahn, LJ
Obermeier, SM
Kapa, LL
AF Brady, Nancy C.
Anderson, Christa J.
Hahn, Laura J.
Obermeier, Sara M.
Kapa, Leah L.
TI Eye Tracking as a Measure of Receptive Vocabulary in Children with
Autism Spectrum Disorders
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Speech comprehension; Receptive language; Autism spectrum disorders; Eye
tracking
ID COMMUNICATIVE DEVELOPMENT INVENTORY; YOUNG-CHILDREN; PRELINGUISTIC
PREDICTORS; PREFERENTIAL LOOKING; EXPRESSIVE LANGUAGE;
DEVELOPMENTAL-DISABILITIES; ALTERNATIVE COMMUNICATION;
WILLIAMS-SYNDROME; DOWNS-SYNDROME; COMPREHENSION
AB This study examined the utility of eye tracking research technology to measure speech comprehension in 14 young boys with autism spectrum disorders (ASD) and 15 developmentally matched boys with typical development. Using eye tracking research technology, children were tested on individualized sets of known and unknown words, identified based on their performance on the Peabody Picture Vocabulary Test. Children in both groups spent a significantly longer amount of time looking at the target picture when previous testing indicated the word was known (known condition). Children with ASD spent similar amounts of time looking at the target and non-target pictures when previous testing indicated the word was unknown (unknown condition). However, children with typical development looked longer at the target pictures in the unknown condition as well, potentially suggesting emergent vocabulary knowledge.
C1 [Brady, Nancy C.] Univ Kansas, Lawrence, KS 66045 USA.
[Anderson, Christa J.; Hahn, Laura J.; Obermeier, Sara M.; Kapa, Leah L.] Univ Kansas, Life Span Inst, Lawrence, KS 66045 USA.
RP Brady, NC (reprint author), Univ Kansas, 1000 Sunnyside Ave,Room 3008, Lawrence, KS 66045 USA.
EM nbrady@ku.edu
FU Kansas Center for Autism Research and Training; NIH [NICHD P30 HD002528,
NICHD R01 HD07690]
FX This research was supported by the Kansas Center for Autism Research and
Training and the NIH [NICHD P30 HD002528, NICHD R01 HD07690.
CR Anderson CJ, 2006, J CLIN EXP NEUROPSYC, V28, P1238, DOI 10.1080/13803390500376790
ASL, 2008, ASL EYE TRACK 6 EYE
Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x
BEHREND DA, 1990, CHILD DEV, V61, P681, DOI 10.1111/j.1467-8624.1990.tb02811.x
Bopp KD, 2011, J CHILD LANG, V38, P485, DOI 10.1017/S0305000910000140
Bornstein MH, 2012, J CHILD LANG, V39, P899, DOI 10.1017/S0305000911000407
Brady N., 2000, AUGMENTATIVE ALTERNA, V16, P197, DOI 10.1080/07434610012331279054
Brady NC, 2013, J SPEECH LANG HEAR R, V56, P1595, DOI 10.1044/1092-4388(2013/12-0102)
CAULEY KM, 1989, AM J MENT RETARD, V94, P53
Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
Colombo J, 2001, ANNU REV PSYCHOL, V52, P337, DOI 10.1146/annurev.psych.52.1.337
CUNNINGHAM CC, 1985, J CHILD PSYCHOL PSYC, V26, P255, DOI 10.1111/j.1469-7610.1985.tb02264.x
Drager KDR, 2006, AM J SPEECH-LANG PAT, V15, P112, DOI 10.1044/1058-0360(2006/012)
Dunn L. M., 2007, PEABODY PICTURE VOCA
Eye-Gaze Response Interface Computer Aid (ERICA) Inc., 2001, GAZETRACKER
Facon B, 2002, AM J MENT RETARD, V107, P91, DOI 10.1352/0895-8017(2002)107<0091:CARVAS>2.0.CO;2
Fenson L., 2006, MACARTHUR BATES COMM
Fenson Larry, 1994, Monographs of the Society for Research in Child Development, V59, P1
Fernald A, 2008, DEVELOPMENTAL PSYCHOLINGUISTICS: ON-LINE METHODS IN CHILDREN'S LANGUAGE PROCESSING, P97
Geytenbeek JJM, 2010, AUGMENT ALTERN COMM, V26, P97, DOI 10.3109/07434618.2010.482445
Golinkoff RM, 2013, PERSPECT PSYCHOL SCI, V8, P316, DOI 10.1177/1745691613484936
GOLINKOFF RM, 1987, J CHILD LANG, V14, P23
Goodwin A, 2012, AUTISM RES, V5, P109, DOI 10.1002/aur.1220
Houston-Price C, 2007, J CHILD LANG, V34, P701, DOI 10.1017/S0305000907008124
Hudry K, 2010, INT J LANG COMM DIS, V45, P681, DOI 10.3109/13682820903461493
HUTTENLOCHER J, 1991, DEV PSYCHOL, V27, P236, DOI 10.1037/0012-1649.27.2.236
Johnson AL, 2012, RES AUTISM SPECT DIS, V6, P1053, DOI 10.1016/j.rasd.2012.01.004
Lord C., 1997, AUTISM DIAGNOSTIC OB
Luyster R, 2007, J SPEECH LANG HEAR R, V50, P667, DOI 10.1044/1092-4388(2007/047)
Maljaars J, 2012, J AUTISM DEV DISORD, V42, P2181, DOI 10.1007/s10803-012-1476-1
McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
McDougall S, 2012, AUGMENT ALTERN COMM, V28, P127, DOI 10.3109/07434618.2012.677958
McDuffie A, 2005, J SPEECH LANG HEAR R, V48, P1080, DOI 10.1044/1092-4388(2005/075)
Mercadante MT, 2006, ARQ NEURO-PSIQUIAT, V64, P559, DOI 10.1590/S0004-282X2006000400003
Mervis CB, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P153
Mullen E, 1995, MULLEN SCALES EARLY
Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
Preis J., 2006, FOCUS AUTISM OTHER D, V21, P194, DOI [10.1177/10883576060210040101, DOI 10.1177/10883576060210040101]
Ray-Subramanian CE, 2012, J AUTISM DEV DISORD, V42, P2113, DOI 10.1007/s10803-012-1463-6
Riby D, 2009, J INTELL DISABIL RES, V53, P169, DOI 10.1111/j.1365-2788.2008.01142.x
Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z
Robinson C. W., 2000, INT C INF STUD JUL 2
Romski M. A., 1996, BREAKING SPEECH BARR
Sasson NJ, 2008, AUTISM RES, V1, P31, DOI 10.1002/aur.4
Sevcik R., 2002, EXEMPLARY PRACTICES
Smith A, 1997, INT J NEUROSCI, V92, P73
Smith V, 2007, J SPEECH LANG HEAR R, V50, P149, DOI 10.1044/1092-4388(2007/013)
Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
SPELKE E, 1976, COGNITIVE PSYCHOL, V8, P553, DOI 10.1016/0010-0285(76)90018-9
SPELKE ES, 1979, DEV PSYCHOL, V15, P626
Styles S, 2009, J CHILD LANG, V36, P895, DOI 10.1017/S0305000908009264
Swensen LD, 2007, CHILD DEV, V78, P542, DOI 10.1111/j.1467-8624.2007.01022.x
Thistle JJ, 2013, AUGMENT ALTERN COMM, V29, P235, DOI 10.3109/07434618.2013.815800
Tincoff R, 1999, PSYCHOL SCI, V10, P172, DOI 10.1111/1467-9280.00127
TOMASELLO M, 1994, MONOGR SOC RES CHILD, V59, P174
Vivanti G, 2008, J EXP CHILD PSYCHOL, V101, P186, DOI 10.1016/j.jecp.2008.04.008
Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
Volden J, 2011, AM J SPEECH-LANG PAT, V20, P200, DOI 10.1044/1058-0360(2011/10-0035)
Watt N, 2006, J SPEECH LANG HEAR R, V49, P1224, DOI 10.1044/1092-4388(2006/088)
Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
Yoder P. J., 1997, AM J SPEECH-LANG PAT, V6, P59
Zampini L, 2009, INT J LANG COMM DIS, V44, P1063, DOI [10.1080/13682820802398288, 10.3109/13682820802398288]
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 63
TC 4
Z9 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
EI 1477-3848
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD JUN
PY 2014
VL 30
IS 2
BP 147
EP 159
DI 10.3109/07434618.2014.904923
PG 13
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA AI6XL
UT WOS:000337020600005
PM 24773020
ER
PT J
AU Wolf, RC
Philippi, CL
Motzkin, JC
Baskaya, MK
Koenigs, M
AF Wolf, Richard C.
Philippi, Carissa L.
Motzkin, Julian C.
Baskaya, Mustafa K.
Koenigs, Michael
TI Ventromedial prefrontal cortex mediates visual attention during facial
emotion recognition
SO BRAIN
LA English
DT Article
DE attention; emotion; prefrontal cortex; social cognition; lesion studies;
eye tracking
ID FRONTAL-LOBE DAMAGE; AMYGDALA DAMAGE; ORBITOFRONTAL CORTEX; BILATERAL
DAMAGE; DECISION-MAKING; EXPRESSIONS; LESIONS; AUTISM; FACE; CONNECTIONS
AB The ventromedial prefrontal cortex plays a crucial role in regulating emotion and social behavior, yet the precise mechanisms underlying this function remain unclear. Using eye-tracking in patients with brain lesions, Wolf et al. show that ventromedial prefrontal cortex is critical for directing visual attention during facial emotion recognition.The ventromedial prefrontal cortex is known to play a crucial role in regulating human social and emotional behaviour, yet the precise mechanisms by which it subserves this broad function remain unclear. Whereas previous neuropsychological studies have largely focused on the role of the ventromedial prefrontal cortex in higher-order deliberative processes related to valuation and decision-making, here we test whether ventromedial prefrontal cortex may also be critical for more basic aspects of orienting attention to socially and emotionally meaningful stimuli. Using eye tracking during a test of facial emotion recognition in a sample of lesion patients, we show that bilateral ventromedial prefrontal cortex damage impairs visual attention to the eye regions of faces, particularly for fearful faces. This finding demonstrates a heretofore unrecognized function of the ventromedial prefrontal cortex-the basic attentional process of controlling eye movements to faces expressing emotion.
C1 [Wolf, Richard C.; Philippi, Carissa L.; Motzkin, Julian C.; Koenigs, Michael] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA.
[Wolf, Richard C.; Motzkin, Julian C.] Univ Wisconsin, Neurosci Training Program, Madison, WI 53706 USA.
[Motzkin, Julian C.] Univ Wisconsin, Med Scientist Training Program, Madison, WI 53705 USA.
[Baskaya, Mustafa K.] Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USA.
RP Koenigs, M (reprint author), Univ Wisconsin, Dept Psychiat, 6001 Res Pk Blvd, Madison, WI 53719 USA.
EM mrkoenigs@wisc.edu
FU NIMH [MH086787]; NIH [T32GM008692, T32GM007507, T32MH018931]; NSF
[DGE-1256259]
FX This work was funded by a grant from NIMH (MH086787), with additional
support from NIH grants T32GM008692, T32GM007507, T32MH018931, as well
as a fellowship from the NSF (DGE-1256259).
CR Adolphs R, 1999, NEUROPSYCHOLOGIA, V37, P1111, DOI 10.1016/S0028-3932(99)00039-1
ADOLPHS R, 1994, NATURE, V372, P669, DOI 10.1038/372669a0
Adolphs R, 2005, NATURE, V433, P68, DOI 10.1038/nature03086
Avants B, 2004, NEUROIMAGE, V23, pS139, DOI 10.1016/j.neuroimage.2004.07.010
Barbas H, 2000, BRAIN RES BULL, V52, P319, DOI 10.1016/S0361-9230(99)00245-2
Barrash J, 2000, DEV NEUROPSYCHOL, V18, P355, DOI 10.1207/S1532694205Barrash
Bechara A, 1997, SCIENCE, V275, P1293, DOI 10.1126/science.275.5304.1293
Beck A. T., 1996, BDI 2 BECK DEPRESSIO
Blair RJR, 2007, TRENDS COGN SCI, V11, P387, DOI 10.1016/j.tics.2007.07.003
Blumer D., 1975, PSYCHIAT ASPECTS NEU, P151
Brett M, 2001, NEUROIMAGE, V14, P486, DOI 10.1006/nimg.2001.0845
Camille N, 2004, SCIENCE, V304, P1167, DOI 10.1126/science.1094550
Cavada C, 2000, CEREB CORTEX, V10, P220, DOI 10.1093/cercor/10.3.220
Ciaramelli E, 2007, SOC COGN AFFECT NEUR, V2, P84, DOI 10.1093/scan/nsm001
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Damasio AR, 1996, PHILOS T R SOC B, V351, P1413, DOI 10.1098/rstb.1996.0125
ESLINGER PJ, 1985, NEUROLOGY, V35, P1731
Etkin A, 2007, AM J PSYCHIAT, V164, P1476, DOI 10.1176/appi.ajp.2007.07030504
Fellows LK, 2011, ANN NY ACAD SCI, V1239, P51, DOI 10.1111/j.1749-6632.2011.06229.x
Fellows LK, 2003, BRAIN, V126, P1830, DOI 10.1093/brain/awg180
Ghashghaei HT, 2002, NEUROSCIENCE, V115, P1261, DOI 10.1016/S0306-4522(02)00446-3
Harlow J. M., 1868, PUBLICATIONS MASSACH, V2, P327
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Heberlein AS, 2008, J COGNITIVE NEUROSCI, V20, P721, DOI 10.1162/jocn.2008.20049
Henri-Bhargava A, 2012, NEUROPSYCHOLOGIA, V50, P1536, DOI 10.1016/j.neuropsychologia.2012.03.006
Hernandez N, 2009, NEUROPSYCHOLOGIA, V47, P1004, DOI 10.1016/j.neuropsychologia.2008.10.023
Hornak J, 2003, BRAIN, V126, P1691, DOI 10.1093/brain/awg168
Hornak J, 1996, NEUROPSYCHOLOGIA, V34, P247, DOI 10.1016/0028-3932(95)00106-9
Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
Karsh R, 1983, EYE MOVEMENTS PSYCHO
Kawasaki H, 2001, NAT NEUROSCI, V4, P15
Kennedy DP, 2010, NEUROPSYCHOLOGIA, V48, P3392, DOI 10.1016/j.neuropsychologia.2010.06.025
Koenigs M, 2007, J NEUROSCI, V27, P951, DOI 10.1523/JNEUROSCI.4606-06.2007
Koenigs M, 2007, NATURE, V446, P908, DOI 10.1038/nature05631
Krajbich I, 2009, J NEUROSCI, V29, P2188, DOI 10.1523/JNEUROSCI.5086-08.2009
LAMBERT RH, 1974, BEHAV RES METH INSTR, V6, P525, DOI 10.3758/BF03201340
Levy DJ, 2012, CURR OPIN NEUROBIOL, V22, P1027, DOI 10.1016/j.conb.2012.06.001
Lundqvist D., 1998, KAROLINSKA DIRECTED
Myers-Schulz B, 2012, MOL PSYCHIATR, V17, P132, DOI 10.1038/mp.2011.88
O'Doherty JP, 2011, ANN NY ACAD SCI, V1239, P118, DOI 10.1111/j.1749-6632.2011.06290.x
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Pessoa L, 2010, NAT REV NEUROSCI, V11, P773, DOI 10.1038/nrn2920
Reitan R.M., 1985, HALSTEAD REITAN NEUR
Roy AK, 2009, NEUROIMAGE, V45, P614, DOI 10.1016/j.neuroimage.2008.11.030
Roy M, 2012, TRENDS COGN SCI, V16, P147, DOI 10.1016/j.tics.2012.01.005
Salmond CH, 2005, CURR OPIN CRIT CARE, V11, P111, DOI 10.1097/01.ccx.0000155358.31983.37
Segonne F, 2004, NEUROIMAGE, V22, P1060, DOI 10.1016/j.neuroimage.2004.03.032
Shamay-Tsoory SG, 2003, J COGNITIVE NEUROSCI, V15, P324, DOI 10.1162/089892903321593063
Shamay-Tsoory SG, 2007, BRAIN, V130, P1663, DOI 10.1093/brain/awm093
Shaw P, 2005, J COGNITIVE NEUROSCI, V17, P1410, DOI 10.1162/0898929054985491
Spielberger C. D., 1983, MANUAL STATE TRAIT A
Tsuchida A, 2012, CEREB CORTEX, V22, P2904, DOI 10.1093/cercor/bhr370
Vecera SP, 2004, NEUROPSYCHOLOGIA, V42, P1657, DOI 10.1016/j.neuropsychologia.2004.04.009
Wechsler D., 2008, WECHSLER ADULT INTEL
Whalen PJ, 1998, J NEUROSCI, V18, P411
Wheeler EZ, 2008, BRAIN, V131, P1323, DOI 10.1093/brain/awn041
Wilkinson G. S., 2006, WRAT4 WIDE RANGE ACH
Young AW, 1996, NEUROPSYCHOLOGIA, V34, P31, DOI 10.1016/0028-3932(95)00062-3
Young L, 2010, NEURON, V65, P845, DOI 10.1016/j.neuron.2010.03.003
NR 59
TC 1
Z9 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD JUN
PY 2014
VL 137
BP 1772
EP 1780
DI 10.1093/brain/awu063
PN 6
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AI6ZU
UT WOS:000337028900024
PM 24691392
ER
PT J
AU DeGutis, J
Cohan, S
Nakayama, K
AF DeGutis, Joseph
Cohan, Sarah
Nakayama, Ken
TI Holistic face training enhances face processing in developmental
prosopagnosia
SO BRAIN
LA English
DT Article
DE developmental prosopagnosia; computer-based cognitive remediation;
configural/holistic processing
ID CONGENITAL PROSOPAGNOSIA; ACQUIRED PROSOPAGNOSIA; RECOGNITION ABILITY;
INDIVIDUAL FACES; TEMPORAL CORTEX; MEMORY TEST; PERCEPTION; REVEALS;
AUTISM; DIFFICULTIES
AB Recent case studies suggest that face recognition can be improved in individual developmental prosopagnosics. Using a 3-week online program targeting holistic face processing, DeGutis et al. reveal perceptual improvements in 24 subjects. Those who reached more difficult levels of training showed the greatest improvements in holistic processing.Prosopagnosia has largely been regarded as an untreatable disorder. However, recent case studies using cognitive training have shown that it is possible to enhance face recognition abilities in individuals with developmental prosopagnosia. Our goal was to determine if this approach could be effective in a larger population of developmental prosopagnosics. We trained 24 developmental prosopagnosics using a 3-week online face-training program targeting holistic face processing. Twelve subjects with developmental prosopagnosia were assessed before and after training, and the other 12 were assessed before and after a waiting period, they then performed the training, and were then assessed again. The assessments included measures of front-view face discrimination, face discrimination with view-point changes, measures of holistic face processing, and a 5-day diary to quantify potential real-world improvements. Compared with the waiting period, developmental prosopagnosics showed moderate but significant overall training-related improvements on measures of front-view face discrimination. Those who reached the more difficult levels of training ('better' trainees) showed the strongest improvements in front-view face discrimination and showed significantly increased holistic face processing to the point of being similar to that of unimpaired control subjects. Despite challenges in characterizing developmental prosopagnosics' everyday face recognition and potential biases in self-report, results also showed modest but consistent self-reported diary improvements. In summary, we demonstrate that by using cognitive training that targets holistic processing, it is possible to enhance face perception across a group of developmental prosopagnosics and further suggest that those who improved the most on the training task received the greatest benefits.
C1 [DeGutis, Joseph] Boston Div VA Healthcare Syst, Geriatr Res Educ & Clin Ctr GRECC, Jamaica Plain, MA USA.
[DeGutis, Joseph; Cohan, Sarah; Nakayama, Ken] Harvard Univ, Dept Psychol, Vis Sci Lab, Cambridge, MA 02138 USA.
RP DeGutis, J (reprint author), Boston VA Healthcare Syst, Geriatr Res Educ & Clin Ctr GRECC, Boston, MA 02130 USA.
EM degutis@wjh.harvard.edu
FU National Institutes of Health [5R01EY013602-07]
FX We would like to acknowledge funding support from the National
Institutes of Health 5R01EY013602-07 awarded to KN and JD's Veterans
Affairs Career Development Award.
CR Ahissar M, 2004, TRENDS COGN SCI, V8, P457, DOI 10.1016/j.tics.2004.08.011
Avidan G, 2011, NEUROPSYCHOLOGIA, V49, P2541, DOI 10.1016/j.neuropsychologia.2011.05.002
Avidan G, 2014, CEREB CORTEX, V24, P1565, DOI 10.1093/cercor/bht007
Avidan G, 2009, CURR BIOL, V19, P1146, DOI 10.1016/j.cub.2009.04.060
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Barton JJS, 2003, BRAIN COGNITION, V51, P12, DOI 10.1016/S0278-2626(02)00516-X
Bentin S, 2007, J COGNITIVE NEUROSCI, V19, P132, DOI 10.1162/jocn.2007.19.1.132
BEYN ES, 1962, J NEUROL NEUROSUR PS, V25, P154, DOI 10.1136/jnnp.25.2.154
Bowles DC, 2009, COGN NEUROPSYCHOL, V26, P423, DOI 10.1080/02643290903343149
Brunsdon R, 2006, COGN NEUROPSYCHOL, V23, P822, DOI 10.1080/02643290500441841
Bukach CM, 2006, J COGNITIVE NEUROSCI, V18, P48, DOI 10.1162/089892906775250094
Burk MH, 2007, J SPEECH LANG HEAR R, V50, P25, DOI 10.1044/1092-4388(2007/003)
Busigny T, 2010, NEUROPSYCHOLOGIA, V48, P4057, DOI 10.1016/j.neuropsychologia.2010.09.017
Chatterjee G, 2012, COGN NEUROPSYCHOL, V29, P482, DOI 10.1080/02643294.2012.756809
Dalrymple KA, 2012, COGN NEUROPSYCHOL, V29, P393, DOI 10.1080/02643294.2012.722547
DeGutis J, 2012, COGN NEUROPSYCHOL, V29, P419, DOI 10.1080/02643294.2012.754745
DeGutis J, 2013, COGNITION, V126, P87, DOI 10.1016/j.cognition.2012.09.004
DeGutis J, 2008, J VIS, V8, p184a
DeGutis J, 2012, VIS COGN, V20, P1242, DOI 10.1080/13506285.2012.744788
DeGutis JM, 2007, J COGNITIVE NEUROSCI, V19, P1790, DOI 10.1162/jocn.2007.19.11.1790
de Xivry JJO, 2008, J NEUROPSYCHOL, V2, P245, DOI 10.1348/174866407X260199
Duchaine B, 2007, COGN NEUROPSYCHOL, V24, P419, DOI 10.1080/02643290701380491
Duchaine B, 2006, NEUROPSYCHOLOGIA, V44, P576, DOI 10.1016/j.neuropsychologia.2005.07.001
Duchaine BC, 2006, CURR OPIN NEUROBIOL, V16, P166, DOI 10.1016/j.conb.2006.03.003
ELLIS HD, 1988, DEV NEUROPSYCHOL, V4, P283
Fahle M, 2005, CURR OPIN NEUROBIOL, V15, P154, DOI 10.1016/j.conb.2005.03.010
Farah MJ, 1998, PSYCHOL REV, V105, P482, DOI 10.1037//0033-295X.105.3.482
Garrido L, 2009, BRAIN, V132, P3443, DOI 10.1093/brain/awp271
Germine L, 2012, PSYCHON B REV, V19, P847, DOI 10.3758/s13423-012-0296-9
Jacques C, 2009, J VISION, V9, DOI 10.1167/9.6.8
Kennerknecht I, 2008, AM J MED GENET A, V146A, P2863, DOI 10.1002/ajmg.a.32552
Kennerknecht I, 2006, AM J MED GENET A, V140A, P1617, DOI 10.1002/ajmg.a.31343
Knottnerus JA, 2001, J CLIN EPIDEMIOL, V54, P109, DOI 10.1016/S0895-4356(00)00276-6
Lee Y, 2010, CORTEX, V46, P949, DOI 10.1016/j.cortex.2009.07.012
Marotta JJ, 2002, COGN NEUROPSYCHOL, V19, P31, DOI 10.1080/02643290143000079
Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4
Mayer E, 2007, BEHAVIORAL AND COGNITIVE NEUROLOGY OF STROKE, P315, DOI 10.1017/CBO9780511544880.017
McKone E, 2009, VISION RES, V49, P268, DOI 10.1016/j.visres.2008.10.020
Owen AM, 2010, NATURE, V465, P775, DOI 10.1038/nature09042
Palermo R, 2011, NEUROPSYCHOLOGIA, V49, P1226, DOI 10.1016/j.neuropsychologia.2011.02.021
Pitcher D, 2009, CURR BIOL, V19, P319, DOI 10.1016/j.cub.2009.01.007
Polster M R, 1996, J Int Neuropsychol Soc, V2, P240
Ramon M, 2010, NEUROPSYCHOLOGIA, V48, P933, DOI 10.1016/j.neuropsychologia.2009.11.014
Ramon M, 2010, CORTEX, V46, P374, DOI 10.1016/j.cortex.2009.06.001
Rossion B, 2008, ACTA PSYCHOL, V128, P274, DOI 10.1016/j.actpsy.2008.02.003
Schmalzl L, 2008, COGN NEUROPSYCHOL, V25, P704, DOI 10.1080/02643290802299350
SCHWEICH M, 1992, APPL COGNITIVE PSYCH, V6, P161, DOI 10.1002/acp.2350060206
Soderqvist S, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00271
Tanaka JW, 2004, COGNITION, V93, pB1, DOI 10.1016/j.cognition.2003.09.011
Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
Thomas AL, 2008, ARCH CLIN NEUROPSYCH, V23, P175, DOI 10.1016/j.acn.2007.10.003
Thomas C, 2008, J COGNITIVE NEUROSCI, V20, P268, DOI 10.1162/jocn.2008.20025
Towler J, 2012, NEUROPSYCHOLOGIA, V50, P3588, DOI 10.1016/j.neuropsychologia.2012.10.017
Van Breukelen GJP, 2006, J CLIN EPIDEMIOL, V59, P920, DOI 10.1016/j.jclinepi.2006.02.007
Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
Wilmer JB, 2010, P NATL ACAD SCI USA, V107, P5238, DOI 10.1073/pnas.0913053107
Wilmer JB, 2012, COGN NEUROPSYCHOL, V29, P360, DOI 10.1080/02643294.2012.753433
Yardley L, 2008, J PSYCHOSOM RES, V65, P445, DOI 10.1016/j.jpsychores.2008.03.013
YOUNG AW, 1985, BRIT J PSYCHOL, V76, P495
NR 59
TC 3
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD JUN
PY 2014
VL 137
BP 1781
EP 1798
DI 10.1093/brain/awu062
PN 6
PG 18
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AI6ZU
UT WOS:000337028900025
PM 24691394
ER
PT J
AU Zielinski, BA
Prigge, MBD
Nielsen, JA
Froehlich, AL
Abildskov, TJ
Anderson, JS
Fletcher, PT
Zygmunt, KM
Travers, BG
Lange, N
Alexander, AL
Bigler, ED
Lainhart, JE
AF Zielinski, Brandon A.
Prigge, Molly B. D.
Nielsen, Jared A.
Froehlich, Alyson L.
Abildskov, Tracy J.
Anderson, Jeffrey S.
Fletcher, P. Thomas
Zygmunt, Kristen M.
Travers, Brittany G.
Lange, Nicholas
Alexander, Andrew L.
Bigler, Erin D.
Lainhart, Janet E.
TI Longitudinal changes in cortical thickness in autism and typical
development
SO BRAIN
LA English
DT Article
DE autism; brain development; developmental neuroimaging; human brain
mapping; MRI
ID HUMAN CEREBRAL-CORTEX; MAGNETIC-RESONANCE IMAGES; AGE 2 YEARS; HEAD
CIRCUMFERENCE; BRAIN VOLUME; INTELLECTUAL ABILITY; SPECTRUM DISORDERS;
SURFACE-AREA; MRI; CHILDREN
AB The natural history of brain growth in autism spectrum disorders (ASD) remains unclear. Zielinski et al. examine longitudinal changes in cortical thickness in individuals with autism and typically-developing controls. Cortical development in ASD appears to undergo three phases, and developmental abnormalities are region-specific, age-dependent, and remain dynamic well into adulthood.The natural history of brain growth in autism spectrum disorders remains unclear. Cross-sectional studies have identified regional abnormalities in brain volume and cortical thickness in autism, although substantial discrepancies have been reported. Preliminary longitudinal studies using two time points and small samples have identified specific regional differences in cortical thickness in the disorder. To clarify age-related trajectories of cortical development, we examined longitudinal changes in cortical thickness within a large mixed cross-sectional and longitudinal sample of autistic subjects and age- and gender-matched typically developing controls. Three hundred and forty-five magnetic resonance imaging scans were examined from 97 males with autism (mean age = 16.8 years; range 3-36 years) and 60 males with typical development (mean age = 18 years; range 4-39 years), with an average interscan interval of 2.6 years. FreeSurfer image analysis software was used to parcellate the cortex into 34 regions of interest per hemisphere and to calculate mean cortical thickness for each region. Longitudinal linear mixed effects models were used to further characterize these findings and identify regions with between-group differences in longitudinal age-related trajectories. Using mean age at time of first scan as a reference (15 years), differences were observed in bilateral inferior frontal gyrus, pars opercularis and pars triangularis, right caudal middle frontal and left rostral middle frontal regions, and left frontal pole. However, group differences in cortical thickness varied by developmental stage, and were influenced by IQ. Differences in age-related trajectories emerged in bilateral parietal and occipital regions (postcentral gyrus, cuneus, lingual gyrus, pericalcarine cortex), left frontal regions (pars opercularis, rostral middle frontal and frontal pole), left supramarginal gyrus, and right transverse temporal gyrus, superior parietal lobule, and paracentral, lateral orbitofrontal, and lateral occipital regions. We suggest that abnormal cortical development in autism spectrum disorders undergoes three distinct phases: accelerated expansion in early childhood, accelerated thinning in later childhood and adolescence, and decelerated thinning in early adulthood. Moreover, cortical thickness abnormalities in autism spectrum disorders are region-specific, vary with age, and may remain dynamic well into adulthood.
C1 [Zielinski, Brandon A.; Prigge, Molly B. D.] Univ Utah, Dept Pediat, Salt Lake City, UT USA.
[Zielinski, Brandon A.] Univ Utah, Dept Neurol, Salt Lake City, UT USA.
[Zielinski, Brandon A.] PCMC, Salt Lake City, UT 84113 USA.
[Prigge, Molly B. D.; Nielsen, Jared A.; Anderson, Jeffrey S.] Univ Utah, Dept Radiol, Salt Lake City, UT 84132 USA.
[Froehlich, Alyson L.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
[Abildskov, Tracy J.; Bigler, Erin D.] Brigham Young Univ, Neurosci Ctr, Provo, UT 84602 USA.
[Anderson, Jeffrey S.] Univ Utah, Interdept Program Neurosci, Salt Lake City, UT USA.
[Fletcher, P. Thomas; Zygmunt, Kristen M.] Univ Utah, Sci Comp & Imaging Inst, Salt Lake City, UT USA.
[Fletcher, P. Thomas] Univ Utah, Sch Comp, Salt Lake City, UT USA.
[Travers, Brittany G.; Alexander, Andrew L.; Lainhart, Janet E.] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI USA.
[Lange, Nicholas] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Lange, Nicholas] Harvard Univ, Sch Med, Dept Biostat, Boston, MA 02115 USA.
[Lange, Nicholas] McLean Hosp, Neurostat Lab, Belmont, MA 02178 USA.
[Alexander, Andrew L.] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA.
[Alexander, Andrew L.; Lainhart, Janet E.] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA.
[Bigler, Erin D.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
RP Zielinski, BA (reprint author), PCMC, 100 N Mario Capecchi Dr,3rd Floor Div Neurol, Salt Lake City, UT 84113 USA.
EM brandon.zielinski@hsc.utah.edu
FU National Institute Of Mental Health [RO1 MH080826, RO1 MH084795, RO1
MH097464, KO8 MH100609, KO8 MH092697]; Eunice Kennedy Shriver NICHD [T32
HD07489, P30 HD003352-45, CHRCDA K12HD001410]; Hartwell Foundation;
Primary Children's Medical Center Foundation
FX The project described was supported by Grant Numbers RO1 MH080826 (JEL,
EDB, ALA, NL), RO1 MH084795 (JEL, PTF, NL), RO1 MH097464 (JEL, NL), KO8
MH100609 (BAZ), and KO8 MH092697 (JSA) from the National Institute Of
Mental Health; Grant Numbers T32 HD07489 (BGT), P30 HD003352-45 (Waisman
Center Core Grant), and CHRCDA K12HD001410 (BAZ) from the Eunice Kennedy
Shriver NICHD; The Hartwell Foundation (BGT); and the Primary Children's
Medical Center Foundation Early Career Development Award (BAZ). The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institute of
Mental Health, the National Institute of Child Health & Development, or
the National Institutes of Health.
CR AKAIKE H, 1974, IEEE T AUTOMAT CONTR, VAC19, P716, DOI 10.1109/TAC.1974.1100705
Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
American Psychiatric Association, 1994, DIAGN STAT MAN MENT
Aylward EH, 2002, NEUROLOGY, V59, P175
BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099
Caviness VS, 1996, CEREB CORTEX, V6, P726, DOI 10.1093/cercor/6.5.726
Chen CH, 2013, P NATL ACAD SCI USA, V110, P17089, DOI 10.1073/pnas.1308091110
Chung MK, 2005, NEUROIMAGE, V25, P1256, DOI 10.1016/j.neuroimage.2004.12.052
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
Courchesne E, 2004, CURR OPIN NEUROL, V17, P489, DOI 10.1097/01.wco.0000137542.14610.b4
Desikan RS, 2006, NEUROIMAGE, V31, P968, DOI 10.1016/j.neuroimage.2006.01.021
Dziobek I, 2010, ARCH GEN PSYCHIAT, V67, P397, DOI 10.1001/archgenpsychiatry.2010.31
Ecker C, 2013, JAMA PSYCHIAT, V70, P59, DOI 10.1001/jamapsychiatry.2013.265
Elliott CD, 1990, DIFFERNTIAL ABILITY
Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
Fischl B, 2002, NEURON, V33, P341, DOI 10.1016/S0896-6273(02)00569-X
Fischl B, 2004, CEREB CORTEX, V14, P11, DOI 10.1093/cercor/bhg087
Giedd JN, 2004, ANN NY ACAD SCI, V1021, P77, DOI 10.1196/annals.1308.009
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
Hardan AY, 2009, BIOL PSYCHIAT, V66, P320, DOI 10.1016/j.biopsych.2009.04.024
Hardan AY, 2001, J CHILD NEUROL, V16, P421, DOI 10.1177/088307380101600607
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
Hua X, 2013, HUM BRAIN MAPP, V34, P425, DOI 10.1002/hbm.21441
Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
Jiao Y, 2010, NEUROIMAGE, V50, P589, DOI 10.1016/j.neuroimage.2009.12.047
Kates WR, 2004, AM J PSYCHIAT, V161, P539, DOI 10.1176/appi.ajp.161.3.539
Kraemer HC, 2000, AM J PSYCHIAT, V157, P163, DOI 10.1176/appi.ajp.157.2.163
Lainhart JE, 1997, J AM ACAD CHILD PSY, V36, P282, DOI 10.1097/00004583-199702000-00019
Lainhart JE, 2003, JAMA-J AM MED ASSOC, V290, P393, DOI 10.1001/jama.290.3.393
Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
Lange N, 2013, FINDMINIC FIND MODEL
Lerch JP, 2006, NEUROIMAGE, V31, P993, DOI 10.1016/j.neuroimage.2006.01.042
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord M, 1994, J AUTISM DEV DISORD, V24, P659
Mak-Fan KM, 2012, J AUTISM DEV DISORD, V42, P419, DOI 10.1007/s10803-011-1261-6
Misaki M, 2012, NEUROIMAGE, V60, P1890, DOI 10.1016/j.neuroimage.2012.01.120
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Panizzon MS, 2009, CEREB CORTEX, V19, P2728, DOI 10.1093/cercor/bhp026
Prigge MD, 2013, AUTISM RES, V6, P78, DOI 10.1002/aur.1265
R Core Team, 2013, R LANG ENV STAT COMP
Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
Reuter M, 2012, NEUROIMAGE, V61, P1402, DOI 10.1016/j.neuroimage.2012.02.084
Reuter M, 2010, NEUROIMAGE, V53, P1181, DOI 10.1016/j.neuroimage.2010.07.020
RStudio, 2012, RSTUDIO INT DEV ENV
Sato JR, 2013, J PSYCHIATR RES, V47, P453, DOI 10.1016/j.jpsychires.2012.11.017
Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040
Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
Shaw P, 2006, NATURE, V440, P676, DOI 10.1038/nature04513
Sowell ER, 2002, DEV MED CHILD NEUROL, V44, P4, DOI 10.1017/S0012162201001591
Wallace GL, 2012, J NEUROSCI, V32, P4856, DOI 10.1523/JNEUROSCI.6214-11.2012
Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Winkler AM, 2010, NEUROIMAGE, V53, P1135, DOI 10.1016/j.neuroimage.2009.12.028
Zielinski BA, 2010, P NATL ACAD SCI USA, V107, P18191, DOI 10.1073/pnas.1003109107
Zielinski BA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049172
NR 63
TC 10
Z9 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD JUN
PY 2014
VL 137
BP 1799
EP 1812
DI 10.1093/brain/awu083
PN 6
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AI6ZU
UT WOS:000337028900026
PM 24755274
ER
PT J
AU Paul, LK
Corsello, C
Kennedy, DP
Adolphs, R
AF Paul, Lynn K.
Corsello, Christina
Kennedy, Daniel P.
Adolphs, Ralph
TI Agenesis of the corpus callosum and autism: a comprehensive comparison
SO BRAIN
LA English
DT Article
DE autism; corpus callosum; developmental neuropathology; connectivity;
social cognition
ID HIGH-FUNCTIONING AUTISM; NORMAL SEX-DIFFERENCES; SPECTRUM DISORDERS;
ASPERGER-SYNDROME; SYSTEMATIZING QUOTIENT; SENTENCE COMPREHENSION;
SOCIAL COGNITION; EMPATHY QUOTIENT; WHITE-MATTER; MR ANALYSIS
AB Isolated congenital absence of the corpus callosum may result in significant social impairments despite intact general intelligence. Paul et al. report that approximately one-third of acallosal adults exhibit an autistic behaviour profile, while another third display social and communication impairments. Findings support a role for the corpus callosum in autism.The corpus callosum, with its similar to 200 million axons, remains enigmatic in its contribution to cognition and behaviour. Agenesis of the corpus callosum is a congenital condition in which the corpus callosum fails to develop; such individuals exhibit localized deficits in non-literal language comprehension, humour, theory of mind and social reasoning. These findings together with parent reports suggest that behavioural and cognitive impairments in subjects with callosal agenesis may overlap with the profile of autism spectrum disorders, particularly with respect to impairments in social interaction and communication. To provide a comprehensive test of this hypothesis, we directly compared a group of 26 adults with callosal agenesis to a group of 28 adults with a diagnosis of autism spectrum disorder but no neurological abnormality. All participants had full-scale intelligence quotient scores > 78 and groups were matched on age, handedness, and gender ratio. Using the Autism Diagnostic Observation Schedule together with current clinical presentation to assess autistic symptomatology, we found that 8/26 (about a third) of agenesis subjects presented with autism. However, more formal diagnosis additionally involving recollective parent-report measures regarding childhood behaviour showed that only 3/22 met complete formal criteria for an autism spectrum disorder (parent reports were unavailable for four subjects). We found no relationship between intelligence quotient and autism symptomatology in callosal agenesis, nor evidence that the presence of any residual corpus callosum differentiated those who exhibited current autism spectrum symptoms from those who did not. Relative to the autism spectrum comparison group, parent ratings of childhood behaviour indicated children with agenesis were less likely to meet diagnostic criteria for autism, even for those who met autism spectrum criteria as adults, and even though there was no group difference in parent report of current behaviours. The findings suggest two broad conclusions. First, they support the hypothesis that congenital disruption of the corpus callosum constitutes a major risk factor for developing autism. Second, they quantify specific features that distinguish autistic behaviour associated with callosal agenesis from autism more generally. Taken together, these two findings also leverage specific questions for future investigation: what are the distal causes (genetic and environmental) determining both callosal agenesis and its autistic features, and what are the proximal mechanisms by which absence of the callosum might generate autistic symptomatology?.
C1 [Paul, Lynn K.; Kennedy, Daniel P.; Adolphs, Ralph] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
[Corsello, Christina] Rady Childrens Hosp, San Diego, CA USA.
[Kennedy, Daniel P.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA.
[Adolphs, Ralph] CALTECH, Div Biol, Pasadena, CA 91125 USA.
RP Paul, LK (reprint author), CALTECH, Baxter MC 228-77,1200 E Calif Blvd, Pasadena, CA 91125 USA.
EM lkpaul@hss.caltech.edu
FU National Institutes of Mental Health [R01MH080721, K99/R00MH094409];
Simons Foundation Autism Research Initiative; National Alliance for
Research on Schizophrenia and Depression Young Investigator Award; Brain
and Behavior Research Foundation
FX This work is supported in part by grants from the National Institutes of
Mental Health (R01MH080721) and the Simons Foundation Autism Research
Initiative to R.A., a National Alliance for Research on Schizophrenia
and Depression Young Investigator Award presented to L.K.P, and a grant
from the National Institutes of Mental Health (K99/R00MH094409) and a
Brain and Behavior Research Foundation Young Investigator Award to
D.P.K.
CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Badaruddin DH, 2007, CHILD PSYCHIAT HUM D, V38, P287, DOI 10.1007/s10578-007-0065-6
Banich MT, 2000, DEV NEUROPSYCHOL, V18, P1, DOI 10.1207/S15326942DN1801_1
BARKOVICH AJ, 1988, AM J ROENTGENOL, V151, P171
Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Barr MS, 2005, NEUROPSYCHOLOGY, V19, P707, DOI 10.1037/0894-4105.19.6.707
Beck A.T., 1996, MANUAL BECK DEPRESSI
Bedeschi MF, 2006, PEDIATR NEUROL, V34, P186, DOI 10.1016/j.pediatrneurol.2005.08.008
Bellani M, 2013, EPIDEMIOL PSYCH SCI, V22, P217, DOI 10.1017/S2045796013000139
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Benton A. L., 1983, CONTRIBUTIONS NEUROP
Boger-Megiddo I, 2006, J AUTISM DEV DISORD, V36, P733, DOI 10.1007/s10803-006-0121-2
Booth R, 2011, PROG BRAIN RES, V189, P303, DOI 10.1016/B978-0-444-53884-0.00031-2
Brown W. S., 2000, COGNITIVE NEUROPSYCH, V5, P135, DOI DOI 10.1080/135468000395781
Brown WS, 2005, BRAIN LANG, V93, P135, DOI 10.1016/j.bandl.2004.09.003
Brown WS, 2001, J INT NEUROPSYCH SOC, V7, P302, DOI 10.1017/S1355617701733048
Brown WS, 1999, NEUROPSYCHOLOGIA, V37, P1165, DOI 10.1016/S0028-3932(99)00011-1
BUCHANAN DC, 1980, PSYCHOTHER PSYCHOSOM, V34, P248
CHIARELLO C, 1980, BRAIN LANG, V11, P128, DOI 10.1016/0093-934X(80)90116-9
Constantino J. N., 2012, SOCIAL RESPONSIVENES, Vsecond
Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
Crawford JR, 2004, BRIT J CLIN PSYCHOL, V43, P245, DOI 10.1348/0144665031752934
EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794
FOWLER PC, 1988, J CLIN PSYCHOL, V44, P398, DOI 10.1002/1097-4679(198805)44:3<398::AID-JCLP2270440314>3.0.CO;2-J
Frith U., 1989, AUTISM EXPLAINING EN
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Glass HC, 2008, AM J MED GENET A, V146A, P2495, DOI 10.1002/ajmg.a.32418
Goldenfeld N., 2005, INT J CLIN NEUROPSYC, V2, P338
Goodyear PWA, 2001, FETAL DIAGN THER, V16, P139, DOI 10.1159/000053898
Hetts SW, 2006, AM J ROENTGENOL, V187, P1343, DOI 10.2214/AJR.05.0146
Hsu YT, 2013, BRAIN TOPOGR, V26, P171, DOI 10.1007/s10548-012-0247-9
Huber-Okrainec J, 2005, BRAIN LANG, V93, P349, DOI 10.1016/j.bandl.2004.11.002
Jeeves MA, 1979, STRUCTURE FUNCTION C
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
Keown CL, 2013, CELL REP, V5, P567, DOI 10.1016/j.celrep.2013.10.003
Kier EL, 1996, AM J NEURORADIOL, V17, P1631
Kilian S, 2008, DEV NEUROPSYCHOL, V33, P74, DOI 10.1080/87565640701729821
Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Lau YC, 2013, J AUTISM DEV DISORD, V43, P1106, DOI 10.1007/s10803-012-1653-2
LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
Liebowitz M R, 1987, Mod Probl Pharmacopsychiatry, V22, P141
LIEDERMAN J, 1985, NEUROPSYCHOLOGIA, V23, P673, DOI 10.1016/0028-3932(85)90068-5
Lombardo MV, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-14
Lord C., 2012, AUTISM DIAGNOSTIC 1
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
Lord C, 2001, AM J MED GENET, V105, P36, DOI 10.1002/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4
Manes F, 1999, J NEUROPSYCH CLIN N, V11, P470
Marco EJ, 2012, J INT NEUROPSYCH SOC, V18, P521, DOI 10.1017/S1355617712000045
Matson JL, 2013, NEUROPSYCHIATRY-LOND, V3, P233, DOI 10.2217/NPY.13.1
Mazzone L, 2012, ANN GEN PSYCHIATR, V11, DOI 10.1186/1744-859X-11-16
MEERWALDT JD, 1983, NEUROPSYCHOLOGIA, V21, P161, DOI 10.1016/0028-3932(83)90083-0
Mennin DS, 2002, J ANXIETY DISORD, V16, P661, DOI 10.1016/S0887-6185(02)00134-2
Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
Moes P, 2009, CHILD CARE HLTH DEV, V35, P656, DOI 10.1111/j.1365-2214.2009.00942.x
Mueller KLO, 2009, BEHAV NEUROSCI, V123, P1000, DOI 10.1037/a0016868
Nyden A, 2004, DEV MED CHILD NEUROL, V46, P448, DOI 10.1017/S001216220400074X
O'brien G, 1994, CALLOSAL AGENESIS NA
Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
Paul LK, 2007, NAT REV NEUROSCI, V8, P287, DOI 10.1038/nrn2107
Paul LK, 2003, BRAIN LANG, V85, P313, DOI 10.1016/S0093-934X(03)00062-2
Paul LK, 2006, INT J PSYCHOPHYSIOL, V61, P47, DOI 10.1016/j.ijpsycho.2005.10.017
Piven J, 1997, AM J PSYCHIAT, V154, P1051
PROBST F P, 1972, Acta Radiologica Diagnosis, V13, P449
RAKIC P, 1968, J COMP NEUROL, V132, P45, DOI 10.1002/cne.901320103
Redcay E, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00573
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Rutter M., 2003, SOCIAL COMMUNICATION
Sajan SA, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003823
SANDERS RJ, 1989, BRAIN LANG, V37, P59, DOI 10.1016/0093-934X(89)90101-6
Santo S, 2012, ULTRASOUND OBST GYN, V40, P513, DOI 10.1002/uog.12315
SAUERWEIN H, 1983, NEUROPSYCHOLOGIA, V21, P167, DOI 10.1016/0028-3932(83)90084-2
Sauerwein HC, 1994, CALLOSAL AGENESIS NA
Shevell MI, 2002, J CHILD NEUROL, V17, P896
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
SOLURSH LP, 1965, J NERV MENT DIS, V141, P180, DOI 10.1097/00005053-196508000-00005
Spielberger C. D., 1983, MANUAL STATE TRAIT A
Symington SH, 2010, SOC NEUROSCI-UK, V5, P296, DOI 10.1080/17470910903462419
TEMPLE CM, 1989, BRAIN LANG, V37, P548, DOI 10.1016/0093-934X(89)90111-9
TEMPLE CM, 1990, BRAIN LANG, V39, P235, DOI 10.1016/0093-934X(90)90013-7
Turk AA, 2010, NEUROPSYCHOLOGIA, V48, P43, DOI 10.1016/j.neuropsychologia.2009.08.009
Tyszka JM, 2011, J NEUROSCI, V31, P15154, DOI 10.1523/JNEUROSCI.1453-11.2011
Tyszka JM, 2014, CEREB CORTEX, V24, P1894, DOI 10.1093/cercor/bht040
Vidal CN, 2006, BIOL PSYCHIAT, V60, P218, DOI 10.1016/j.biopsych.2005.11.011
Wahl M, 2009, AM J NEURORADIOL, V30, P282, DOI 10.3174/ajnr.A1361
Wahlsten D, 2003, BRAIN RES, V971, P47, DOI 10.1016/S0006-8993(03)02354-0
Wechsler D, 1999, WASI ADM SCORING MAN
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
NR 95
TC 3
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD JUN
PY 2014
VL 137
BP 1813
EP 1829
DI 10.1093/brain/awu070
PN 6
PG 17
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AI6ZU
UT WOS:000337028900027
PM 24771497
ER
PT J
AU Semerci, CN
Kalay, E
Yildirim, C
Dincer, T
Ouml;lmez, A
Toraman, B
Kocyigit, A
Bulgu, Y
Okur, V
Satiroglu-Tufan, L
Akarsu, NA
AF Semerci, C. Nur
Kalay, Ersan
Yildirim, Cem
Dincer, Tuba
Olmez, Akgun
Toraman, Bayram
Kocyigit, Ali
Bulgu, Yunus
Okur, Volkan
Satiroglu-Tufan, Lale
Akarsu, Nurten A.
TI Novel splice-site and missense mutations in the ALDH1A3 gene underlying
autosomal recessive anophthalmia/microphthalmia
SO BRITISH JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID RETINOIC ACID; ALDEHYDE DEHYDROGENASE; STRA6 MUTATIONS; MICROPHTHALMIA;
ANOPHTHALMIA; SPECTRUM; AUTISM; HYPOPLASIA; DYSPLASIA; COLOBOMA
AB Aim This study aimed to identify the underlying genetic defect responsible for anophthalmia/microphthalmia.
Methods In total, two Turkish families with a total of nine affected individuals were included in the study. Affymetrix 250 K single nucleotide polymorphism genotyping and homozygosity mapping were used to identify the localisation of the genetic defect in question. Coding region of the ALDH1A3 gene was screened via direct sequencing. cDNA samples were generated from primary fibroblast cell cultures for expression analysis. Reverse transcriptase PCR (RT-PCR) analysis was performed using direct sequencing of the obtained fragments.
Results The causative genetic defect was mapped to chromosome 15q26.3. A homozygous G>A substitution (c. 666G>A) at the last nucleotide of exon 6 in the ALDH1A3 gene was identified in the first family. Further cDNA sequencing of ALDH1A3 showed that the c. 666G>A mutation caused skipping of exon 6, which predicted in-frame loss of 43 amino acids (p. Trp180_Glu222del). A novel missense c. 1398C>A mutation in exon 12 of ALDH1A3 that causes the substitution of a conserved asparagine by lysine at amino acid position 466 (p.Asn466Lys) was observed in the second family. No extraocular findings-except for nevus flammeus in one affected individual and a variant of Dandy-Walker malformation in another affected individual-were observed. Autistic-like behaviour and mental retardation were observed in three cases.
Conclusions In conclusion, novel ALDH1A3 mutations identified in the present study confirm the pivotal role of ALDH1A3 in human eye development. Autistic features, previously reported as an associated finding, were considered to be the result of social deprivation and inadequate parenting during early infancy in the presented families.
C1 [Semerci, C. Nur; Okur, Volkan; Satiroglu-Tufan, Lale] Pamukkale Univ, Sch Med, Dept Med Genet, TR-20020 Kinikli, Denizli, Turkey.
[Kalay, Ersan; Dincer, Tuba; Toraman, Bayram] Karadeniz Tech Univ, Sch Med, Dept Med Biol, Trabzon, Turkey.
[Yildirim, Cem] Pamukkale Univ, Sch Med, Dept Ophthalmol, TR-20020 Kinikli, Denizli, Turkey.
[Olmez, Akgun] Denizli State Hosp, Minist Hlth, Dept Pediat Neurol, Denizli, Turkey.
[Kocyigit, Ali] Pamukkale Univ, Sch Med, Dept Radiol, TR-20020 Kinikli, Denizli, Turkey.
[Bulgu, Yunus] State Hosp, Dept Ophthalmol, Suhut Afyonkarahisar, Afyon, Turkey.
[Akarsu, Nurten A.] Hacettepe Univ, Sch Med, Dept Med Genet, Gene Mapping Lab, Ankara, Turkey.
RP Semerci, CN (reprint author), Pamukkale Univ, Sch Med, Dept Med Genet, TR-20020 Kinikli, Denizli, Turkey.
EM nsemerci1@yahoo.com
FU Pamukkale University Scientific Research Grants Fund [2012ARS001]
FX This study was supported by the Pamukkale University Scientific Research
Grants Fund, grant number 2012ARS001.
CR Abouzeid H, 2011, AM J HUM GENET, V88, P92, DOI 10.1016/j.ajhg.2010.12.002
Aldahmesh MA, 2013, CLIN GENET, V84, P128, DOI 10.1111/cge.12184
ARAUJO J, 2012, TAIWAN J OBSTET GYNE, V51, P616
Casey J, 2011, HUM MUTAT, V32, P1417, DOI 10.1002/humu.21590
Chassaing N, 2014, CLIN GENET, V86, P326, DOI 10.1111/cge.12275
Chassaing N, 2009, HUM MUTAT, V30, pE673, DOI 10.1002/humu.21023
Cvekl A, 2009, EXP EYE RES, V89, P280, DOI 10.1016/j.exer.2009.04.012
Dupe V, 2003, P NATL ACAD SCI USA, V100, P14036, DOI 10.1073/pnas.2336223100
Fares-Taie L, 2013, AM J HUM GENET, V92, P265, DOI 10.1016/j.ajhg.2012.12.003
Gerth-Kahlert Christina, 2013, Mol Genet Genomic Med, V1, P15, DOI 10.1002/mgg3.2
Gonzalez-Rodriguez J, 2010, BRIT J OPHTHALMOL, V94, P1100, DOI 10.1136/bjo.2009.173500
Grun F, 2000, J BIOL CHEM, V275, P41210, DOI 10.1074/jbc.M007376200
Hobson RP, 2010, J CHILD PSYCHOL PSYC, V51, P1235, DOI 10.1111/j.1469-7610.2010.02274.x
Hobson RP, 2003, PHILOS T R SOC B, V358, P335, DOI 10.1098/rstb.2002.1201
Hrdlicka Michal, 2013, Child Adolesc Psychiatry Ment Health, V7, P9, DOI 10.1186/1753-2000-7-9
*INT CLEAR BIRTH D, 2011, MON SYST ANN REP 201
Kayserili H, 2009, HUM MOL GENET, V18, P4357, DOI 10.1093/hmg/ddp391
Maden M, 2007, INT J DEV BIOL, V51, P191, DOI 10.1387/ijdb.062175mm
Marchler-Bauer A, 2011, NUCLEIC ACIDS RES, V39, pD225, DOI 10.1093/nar/gkq1189
Mashiach R, 2004, ULTRASOUND OBST GYN, V24, P640, DOI 10.1002/uog.1748
Moore SA, 1998, STRUCT FOLD DES, V6, P1541, DOI 10.1016/S0969-2126(98)00152-X
Mory A, 2014, EUR J HUM GENET, V22, P419, DOI 10.1038/ejhg.2013.157
Mukaddes NM, 2007, PSYCHIAT CLIN NEUROS, V61, P39, DOI 10.1111/j.1440-1819.2007.01608.x
NEWTON CR, 1989, LANCET, V2, P1481
Pasutto F, 2007, AM J HUM GENET, V80, P550, DOI 10.1086/512203
Ragge N, 2007, EYE, V21, P1290, DOI 10.1038/sj.eye.6702858
Reese MG, 1997, J COMPUT BIOL, V4, P311, DOI 10.1089/cmb.1997.4.311
Roos L, 2014, CLIN GENET, V86, P276, DOI 10.1111/cge.12277
Ross SA, 2000, PHYSIOL REV, V80, P1021
SAYLI BS, 1995, AM J MED GENET, V58, P18, DOI 10.1002/ajmg.1320580105
Steinmetz CG, 1997, STRUCTURE, V5, P701, DOI 10.1016/S0969-2126(97)00224-4
Uz E, 2010, AM J HUM GENET, V86, P789, DOI 10.1016/j.ajhg.2010.04.002
Verma AS, 2007, ORPHANET J RARE DIS, V2, DOI 10.1186/1750-1172-2-47
Wessagowit V, 2005, J DERMATOL SCI, V40, P73, DOI 10.1061/j.jdermsci.2005.05.006
WILSON JG, 1953, AM J ANAT, V92, P189, DOI 10.1002/aja.1000920202
Yahyavi M, 2013, HUM MOL GENET, V22, P3250, DOI 10.1093/hmg/ddt179
NR 36
TC 1
Z9 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0007-1161
EI 1468-2079
J9 BRIT J OPHTHALMOL
JI Br. J. Ophthalmol.
PD JUN
PY 2014
VL 98
IS 6
BP 832
EP 840
DI 10.1136/bjophthalmol-2013-304058
PG 9
WC Ophthalmology
SC Ophthalmology
GA AI6JI
UT WOS:000336979100024
PM 24568872
ER
PT J
AU Majewska, MD
Hill, M
Urbanowicz, E
Rok-Bujko, P
Bienkowski, P
Namyslowska, I
Mierzejewski, P
AF Majewska, Maria Dorota
Hill, Martin
Urbanowicz, Ewa
Rok-Bujko, Paulina
Bienkowski, Przemyslaw
Namyslowska, Irena
Mierzejewski, Pawel
TI Marked elevation of adrenal steroids, especially androgens, in saliva of
prepubertal autistic children
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Autism; Children; Saliva; Steroids; Neurosteroids
ID GABA-A RECEPTOR; SPECTRUM DISORDERS; DEHYDROEPIANDROSTERONE-SULFATE;
IMMUNE-RESPONSE; SEX STEROIDS; PLASMA; NEUROSTEROIDS; HORMONES;
CORTISOL; MERCURY
AB Autism is diagnosed on the basis of behavioral manifestations, but its biomarkers are not well defined. A strong gender bias typifying autism (it is 4-5 times more prevalent in males) suggests involvement of steroid hormones in autism pathobiology. In order to evaluate the potential roles of such hormones in autism, we compared the salivary levels of 22 steroids in prepubertal autistic male and female children from two age groups (3-4 and 7-9 years old) with those in healthy controls. The steroids were analyzed using gas chromatography-mass spectrometry and radioimmunoassay. Statistical analysis (ANOVA) revealed that autistic children had significantly higher salivary concentrations of many steroid hormones (both C21 and C19) than control children. These anomalies were more prominent in older autistic children and in boys. The levels of androgens (androstenediol, dehydroepiandrosterone, androsterone and their polar conjugates) were especially increased, indicative of precocious adrenarche and predictive of early puberty. The concentrations of the steroid precursor, pregnenolone, and of several pregnanolones were also higher in autistic than in healthy children, but cortisol levels were not different. Some steroids, whose levels are raised in autism (allopregnanolone, androsterone, pregnenolone, dehydroepiandrosterone and their sulfate conjugates) are neuroactive and modulate GABA, glutamate, and opioid neurotransmission, affecting brain development and functioning. These steroids may contribute to autism pathobiology and symptoms such as elevated anxiety, sleep disturbances, sensory deficits, and stereotypies among others. We suggest that salivary levels of selected steroids may serve as biomarkers of autism pathology useful for monitoring the progress of therapy.
C1 [Majewska, Maria Dorota; Bienkowski, Przemyslaw; Mierzejewski, Pawel] Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 Warsaw, Poland.
[Hill, Martin] Inst Endocrinol, Prague, Czech Republic.
[Urbanowicz, Ewa; Rok-Bujko, Paulina; Namyslowska, Irena] Inst Psychiat & Neurol, Dept Child & Adolescent Psychiat, PL-02957 Warsaw, Poland.
RP Majewska, MD (reprint author), Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, Sobieskiego 9, PL-02957 Warsaw, Poland.
EM mdmajewska@gmail.com
FU European Commission [MEXC-CT 2006-042371]; Ministry of Science and
Higher Education of Poland
FX We are grateful to the psychologists, M. S. Agnieszka Lucjanek and M. S.
Justyna Szczechowicz-Konciala for help in diagnosis of autistic
children; to Dr. Michal Wroniszewski, Dr. Joanna Grochowska and Ms.
Ursula Rusilowicz from the Synapsis Foundation, and Dr. Anna Szymanska
from the Navicula Foundation for aid in recruitment of autistic
patients. This study was a part of ASTER project funded by the European
Commission grant (MEXC-CT 2006-042371) and by the supplementary grant
from the Ministry of Science and Higher Education of Poland, both to
Maria Dorota Majewska.
CR Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Blatt GJ, 2011, ANAT REC, V294, P1646, DOI 10.1002/ar.21252
Bocian-Sobkowska J, 1998, ENDOCR RES, V24, P969
BROCHU M, 1987, J CLIN ENDOCR METAB, V64, P1283
Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80
Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8
Corbett BA, 2006, PSYCHONEUROENDOCRINO, V31, P59, DOI 10.1016/j.psyneuen.2005.05.011
Croonenberghs J, 2010, NEUROENDOCRINOL LETT, V31, P483
Curin JM, 2003, J AUTISM DEV DISORD, V33, P443, DOI 10.1023/A:1025019030121
DeSoto MC, 2010, ACTA NEUROBIOL EXP, V70, P165
Duszczyk-Budhathoki M, 2012, NEUROCHEM RES, V37, P436, DOI 10.1007/s11064-011-0630-z
El-Baz F, 2013, INT J ADOLESC MED HL, V20, P1, DOI [10.1515/ijamh-2012-0116, DOI 10.1515/IJAMH-2012-0116]
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Frye RE, 2011, PEDIATR RES, V69, p41R, DOI 10.1203/PDR.0b013e318212f16b
Geier DA, 2007, NEUROENDOCRINOL LETT, V28, P565
Geier DA, 2010, INDIAN J MED RES, V131, P500
Geier DA, 2010, ACTA NEUROBIOL EXP, V70, P209
Geier DA, 2012, ACTA NEUROBIOL EXP, V72, P1
Groschl M, 2008, CLIN CHEM, V54, P1759, DOI 10.1373/clinchem.2008.108910
HAUFFA BP, 1988, EUR J PEDIATR, V148, P43, DOI 10.1007/BF00441813
Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
Hill M, 2010, J STEROID BIOCHEM, V121, P594, DOI 10.1016/j.jsbmb.2009.10.012
Hill M, 2001, J CHROMATOGR A, V935, P297, DOI 10.1016/S0021-9673(01)01106-2
Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
Ibanez L, 2000, ENDOCR REV, V21, P671, DOI 10.1210/er.21.6.671
Jeste SS, 2011, CURR OPIN NEUROL, V24, P132, DOI 10.1097/WCO.0b013e3283446450
KOUROUNAKIS PN, 1994, ARZNEIMITTEL-FORSCH, V44-2, P1150
LABELLA FS, 1979, BRAIN RES, V160, P295, DOI 10.1016/0006-8993(79)90426-8
Lapchak PA, 2000, STROKE, V31, P1953
Leskiewicz M, 2008, J PHYSIOL PHARMACOL, V59, P457
Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
Lintas C, 2010, NEUROREPORT, V21, P114, DOI 10.1097/WNR.0b013e328334b343
MAJEWSKA MD, 1992, PROG NEUROBIOL, V38, P379, DOI 10.1016/0301-0082(92)90025-A
MAJEWSKA MD, 1990, BRAIN RES, V526, P143, DOI 10.1016/0006-8993(90)90261-9
Majewska MD, 2010, ACTA NEUROBIOL EXP, V70, P196
MAJEWSKA MD, 1986, SCIENCE, V232, P1004, DOI 10.1126/science.2422758
McCarthy MM, 2010, J NEUROENDOCRINOL, V22, P736, DOI 10.1111/j.1365-2826.2010.02021.x
MONNET FP, 1995, P NATL ACAD SCI USA, V92, P3774, DOI 10.1073/pnas.92.9.3774
Morfin R, 2000, ANN NY ACAD SCI, V917, P971
New MI, 2004, ANN NY ACAD SCI, V1038, P14, DOI 10.1196/annals.1315.009
Parker CR, 1999, STEROIDS, V64, P640, DOI 10.1016/S0039-128X(99)00046-X
PHOENIX CH, 1959, ENDOCRINOLOGY, V65, P369
Priya MDL, 2013, CROAT MED J, V54, P33, DOI 10.3325/cmj.2013.54.33
Rege J, 2012, J ENDOCRINOL, V214, P133, DOI 10.1530/JOE-12-0183
Ruta L, 2011, PSYCHONEUROENDOCRINO, V36, P1154, DOI 10.1016/j.psyneuen.2011.02.007
Rutter M, 2003, J CHILD PSYCHOL PSYC, V44, P1092, DOI 10.1111/1469-7610.00194
Sanchez AM, 2012, J NEUROENDOCRINOL, V24, P195, DOI 10.1111/j.1365-2826.2011.02258.x
Sarachana T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017116
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
Sikora DM, 2006, AM J MED GENET A, V140A, P1511, DOI 10.1002/ajmg.a.31294
Strous RD, 2005, EUR NEUROPSYCHOPHARM, V15, P305, DOI 10.1016/j.euroneuro.2004.12.004
Tierney E, 2006, AM J MED GENET B, V141B, P666, DOI 10.1002/ajmg.b.30368
TORDJMAN S, 1995, J AUTISM DEV DISORD, V25, P295, DOI 10.1007/BF02179290
Tordjman S, 1997, AM J PSYCHIAT, V154, P1626
VELTMAN JC, 1986, ARCH BIOCHEM BIOPHYS, V248, P467, DOI 10.1016/0003-9861(86)90500-X
VINING RF, 1983, CLIN CHEM, V29, P1752
Zheng P, 2009, PROG NEUROBIOL, V89, P134, DOI 10.1016/j.pneurobio.2009.07.001
NR 60
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
EI 1435-165X
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD JUN
PY 2014
VL 23
IS 6
BP 485
EP 498
DI 10.1007/s00787-013-0472-0
PG 14
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AI7HX
UT WOS:000337058200011
PM 24043498
ER
PT J
AU Gabriele, S
Sacco, R
Persico, AM
AF Gabriele, Stefano
Sacco, Roberto
Persico, Antonio M.
TI Blood serotonin levels in autism spectrum disorder: A systematic review
and meta-analysis
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE 5-HT; Autism; Biomarker; Endophenotype; Meta-analysis
ID POOR PLASMA SEROTONIN; 1ST-DEGREE RELATIVES; PLATELET SEROTONIN;
BRAIN-SEROTONIN; RETARDED-CHILDREN; INFANTILE-AUTISM; RECEPTOR-BINDING;
5-HT2A RECEPTOR; TRANSPORTER; ADULTS
AB Elevated blood serotonin (5-HT) levels were the first biomarker identified in autism research. Many studies have contrasted blood 5-HT levels in autistic patients and controls, but different measurement protocols, technologies, and biomaterials have been used through the years. We performed a systematic review and meta-analysis to provide an overall estimate of effect size and between-study heterogeneity, while verifying whether and to what extent different methodological approaches influence the strength of this association. Our literature search strategy identified 551 papers, from which 22 studies providing patient and control blood 5-HT values were selected for meta-analysis. Significantly higher 5-HT levels in autistic patients compared to controls were recorded both in whole blood (WB) [O.R.=4.6; (3.1-5.2); P=1.0 x 10(-12)], and in platelet-rich plasma (PRP) [O.R.=2.6 (1.8-3.9); P=2.7 x 10(-7)]. Predictably, studies measuring 5-HT levels in platelet-poor plasma (PPP) yielded no significant group difference [O.R.=0.54 (0.2-2-0); P=0.36]. Altogether, elevated 5-HT blood levels were recorded in 28.3% in WB and 22.5% in PRP samples of autistic individuals, as reported in 15 and 4 studies, respectively. Studies employing HPLC vs fluorometric assays yield similar cumulative effect sizes, but the former display much lower variability. In summary, despite some limitations mainly due to small study sample sizes, our results significantly reinforce the reliability of elevated 5-HT blood levels as a biomarker in ASD, providing practical indications potentially useful for its inclusion in multimarker diagnostic panels for clinical use. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
C1 [Gabriele, Stefano; Sacco, Roberto; Persico, Antonio M.] Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, Unit Child & Adolescent NeuroPsychiat, I-00128 Rome, Italy.
[Gabriele, Stefano; Sacco, Roberto; Persico, Antonio M.] IRCCS Fdn Santa Lucia, Dept Expt Neurosci, Rome, Italy.
[Persico, Antonio M.] Mafalda Luce Ctr Pervas Dev Disorders, Milan, Italy.
RP Persico, AM (reprint author), Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, Unit Child & Adolescent NeuroPsychiat, Via Alvaro del Portillo 21, I-00128 Rome, Italy.
EM a.persico@unicampus.it
FU Italian Ministry for University, Scientific Research and Technology
[2006058195, 2008BACT54_002]; Italian Ministry of Health
[RFPS-2007-5-640174, RF-2011-02350537]; Fondazione Gaetano e Mafalda
Luce (Milan, Italy); Autism Aid ONLUS (Naples, Italy); Autism Speaks
(Princeton, NJ); Autism Research Institute (San Diego, CA); Innovative
Medicines Initiative Joint Undertaking (EU-AIMS) [115300]
FX This work was supported by the Italian Ministry for University,
Scientific Research and Technology (PRIN n.2006058195 and
n.2008BACT54_002), the Italian Ministry of Health (RFPS-2007-5-640174
and RF-2011-02350537), the Fondazione Gaetano e Mafalda Luce (Milan,
Italy), Autism Aid ONLUS (Naples, Italy), Autism Speaks (Princeton, NJ),
the Autism Research Institute (San Diego, CA), and the Innovative
Medicines Initiative Joint Undertaking (EU-AIMS, n.115300). The authors
declare that these funding sources had no role in study design, in the
collection, analysis and interpretation of the data, in the writing of
this report and in the decision to submit this paper for publication.
CR ABRAMSON RK, 1989, J AUTISM DEV DISORD, V19, P397, DOI 10.1007/BF02212938
American Psychiatric Association, 2013, DIAGN STAT MEN MENT
ANDERSON GM, 1987, J CHILD PSYCHOL PSYC, V28, P885, DOI 10.1111/j.1469-7610.1987.tb00677.x
Anderson GM, 2012, J AUTISM DEV DISORD, V42, P1510, DOI 10.1007/s10803-011-1371-1
BADCOCK NR, 1987, ANN CLIN BIOCHEM, V24, P625
BOGDANSKI DF, 1956, J PHARMACOL EXP THER, V117, P82
Bonnin A, 2011, NATURE, V472, P347, DOI 10.1038/nature09972
Brand T, 2011, CLIN CHEM, V57, P1376, DOI 10.1373/clinchem.2011.163824
Cantor RM, 2005, AM J HUM GENET, V76, P1050, DOI 10.1086/430278
Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
Chugani DC, 2012, PEDIATR CLIN N AM, V59, P63, DOI 10.1016/j.pcl.2011.10.002
Connors SL, 2006, PEDIATR NEUROL, V35, P182, DOI 10.1016/j.pediatrneurol.2006.02.010
Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
COOK EH, 1994, J NEUROCHEM, V63, P465
COOK EH, 1988, BIOL PSYCHIAT, V24, P488, DOI 10.1016/0006-3223(88)90192-8
Cook E H Jr, 1990, J Neuropsychiatry Clin Neurosci, V2, P268
Coutinho AM, 2004, MOL PSYCHIATR, V9, P264, DOI 10.1038/sj.mp.4001409
Croonenberghs J, 2000, NEUROPSYCHOPHARMACOL, V22, P275, DOI 10.1016/S0893-133X(99)00131-1
CUCCARO ML, 1993, J NEUROPSYCH CLIN N, V5, P94
de Villard R, 1986, Encephale, V12, P139
DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006
Egger M, 1997, BRIT MED J, V315, P1533
Freitas B.C., 2012, EXP NEUROL
GELLER E, 1988, J AUTISM DEV DISORD, V18, P119, DOI 10.1007/BF02211822
Gershon MD, 2004, ALIMENT PHARM THERAP, V20, P3, DOI 10.1111/j.1365-2036.2004.02180.x
HANLEY HG, 1977, ARCH GEN PSYCHIAT, V34, P521
HOSHINO Y, 1984, NEUROPSYCHOBIOLOGY, V11, P22, DOI 10.1159/000118045
Hranilovic D, 2007, J AUTISM DEV DISORD, V37, P1934, DOI 10.1007/s10803-006-0324-6
KATSUI T, 1986, J AUTISM DEV DISORD, V16, P69, DOI 10.1007/BF01531579
KUPERMAN S, 1985, J AM ACAD CHILD PSY, V24, P186, DOI 10.1016/S0002-7138(09)60446-5
Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5
LESCH KP, 1993, J NEUROCHEM, V60, P2319, DOI 10.1111/j.1471-4159.1993.tb03522.x
LEVENTHAL BL, 1990, J AUTISM DEV DISORD, V20, P499, DOI 10.1007/BF02216055
Marazziti D, 2000, PHARMACOPSYCHIATRY, V33, P165, DOI 10.1055/s-2000-7588
McBride P. Anne, 1998, Journal of the American Academy of Child and Adolescent Psychiatry, V37, P767, DOI 10.1097/00004583-199807000-00017
Mei H, 2007, AM J HUM GENET, V81, P1251, DOI 10.1086/522307
MINDERAA RB, 1987, BIOL PSYCHIAT, V22, P933, DOI 10.1016/0006-3223(87)90002-3
MINDERAA RB, 1989, J AUTISM DEV DISORD, V19, P129, DOI 10.1007/BF02212724
Mitchell S, 2011, DEV DISABIL RES REV, V17, P130, DOI 10.1002/ddrr.1107
Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0
Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934
Murphy DL, 2008, NAT REV NEUROSCI, V9, P85, DOI 10.1038/nrn2284
Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
Napolioni V, 2011, EUR J HUM GENET, V19, P353, DOI 10.1038/ejhg.2010.180
PERRY BD, 1991, BIOL PSYCHIAT, V30, P121, DOI 10.1016/0006-3223(91)90165-I
Persico A.M., 2009, EXPT MODELS SEROTONI, P78
Persico AM, 2002, MOL PSYCHIATR, V7, P795, DOI 10.1038/sj.mp.4001069
Di Pino G., 2004, Current Neuropharmacology, V2, P403
PIVEN J, 1991, J AUTISM DEV DISORD, V21, P51, DOI 10.1007/BF02206997
Prasad HC, 2005, P NATL ACAD SCI USA, V102, P11545, DOI 10.1073/pnas.0501432102
RITVO ER, 1970, ARCH GEN PSYCHIAT, V23, P566
Ruggeri B, 2013, PSYCHOPHARMACOLOGY B
Sacco R, 2010, AUTISM RES, V3, P237, DOI 10.1002/aur.151
SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
Spivak B, 2004, NEUROPSYCHOBIOLOGY, V50, P157, DOI 10.1159/000079108
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Stone JL, 2004, AM J HUM GENET, V75, P1117, DOI 10.1086/426034
TORDJMAN S, 1995, J AUTISM DEV DISORD, V25, P295, DOI 10.1007/BF02179290
Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185
Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
Vered Y, 2003, HUM PSYCHOPHARM CLIN, V18, P395, DOI 10.1002/hup.489
Walker E, 2008, CLEV CLIN J MED, V75, P431
Walsh P, 2011, NAT REV NEUROSCI, V12, P603, DOI 10.1038/nrn3113
Wan MW, 2013, J CHILD PSYCHOL PSYC, V54, P763, DOI 10.1111/jcpp.12032
Weiss LA, 2006, HUM GENET, V120, P93, DOI 10.1007/s00439-006-0196-z
Weiss LA, 2005, AM J HUM GENET, V76, P33, DOI 10.1086/426697
Weiss LA, 2004, EUR J HUM GENET, V12, P949, DOI 10.1038/sj.ejhg.5201239
Weiss LA, 2006, EUR J HUM GENET, V14, P923, DOI 10.1038/sj.ejhg.5201644
YUWILER A, 1992, J AUTISM DEV DISORD, V22, P33, DOI 10.1007/BF01046401
YUWILER A, 1970, BIOCHEM MED METAB B, V3, P426, DOI 10.1016/0006-2944(70)90010-4
YUWILER A, 1971, J AUTISM CHILD SCHIZ, V1, P421, DOI 10.1007/BF01540533
Zalsman G, 2011, J CHILD ADOL PSYCHOP, V21, P341, DOI 10.1089/cap.2010.0148
NR 72
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD JUN
PY 2014
VL 24
IS 6
BP 919
EP 929
DI 10.1016/j.euroneuro.2014.02.004
PG 11
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AI4YF
UT WOS:000336871900010
PM 24613076
ER
PT J
AU Molenhuis, RT
de Visser, L
Bruining, H
Kas, MJ
AF Molenhuis, Remco T.
de Visser, Leonie
Bruining, Hilgo
Kas, Martien J.
TI Enhancing the value of psychiatric mouse models; differential expression
of developmental behavioral and cognitive profiles in four inbred
strains of mice
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Developmental trajectories; Mouse models; Cognitive flexibility;
Repetitive behavior; BTBR
ID T PLUS TF/J; AUTISM SPECTRUM DISORDER; REPETITIVE BEHAVIOR;
ANIMAL-MODELS; CHILDREN; TRAJECTORIES; RELEVANT; ANXIETY; MOTOR;
SCHIZOPHRENIA
AB The behavioral characterization of animal models of psychiatric disorders is often based upon independent traits measured at adult age. To model the neurodevelopmental aspects of psychiatric pathogenesis, we introduce a novel approach for a developmental behavioral analysis in mice. C57BL/6J (C57) mice were used as a reference strain and compared with 129S1/SvImJ (129Sv), BTBR T+tf/J (BTBR) and A/J (AJ) strains as marker strains for aberrant development. Mice were assessed at pre-adolescence (4 weeks), adolescence (6 weeks), early adulthood (8 weeks) and in adulthood (10-12 weeks) on a series of behavioral tasks measuring general health, neurological reflexes, locomotor activity, anxiety, short- and long-term memory and cognitive flexibility. Developmental delays in short-term object memory were associated with either a hypo-reactive profile in 129Sv mice or a hyper-reactive profile in BTBR mice. Furthermore, BTBR mice showed persistent high levels of repetitive grooming behavior during all developmental stages that was associated with the adult expression of cognitive rigidity. In addition, strain differences in development were observed in puberty onset, touch escape, and body position. These data showed that this longitudinal testing battery provides sufficient behavioral and cognitive resolution during different development stages and offers the opportunity to address the behavioral developmental trajectory in genetic mouse models for neurodevelopmental disorders. Furthermore, the data revealed that the assessment of multiple behavioral and cognitive domains at different developmental stages is critical to determine confounding factors (e.g., impaired motor behavior) that may interfere with the behavioral testing performance in mouse models for brain disorders. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
C1 [Molenhuis, Remco T.; de Visser, Leonie; Bruining, Hilgo; Kas, Martien J.] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, NL-3584 CG Utrecht, Netherlands.
[Bruining, Hilgo] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, NL-3584 CG Utrecht, Netherlands.
RP Kas, MJ (reprint author), Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Univ Sweg 100, NL-3584 CG Utrecht, Netherlands.
EM m.j.h.kas@umcutrecht.nl
FU ZonMW VIDI - Netherlands Organization for Scientific Research (NWO)
[91786327]; EU-AIMS; Innovative Medicines Initiative Joint [115300];
European Union [FP7/2007-2013]; EFPIA companies; Autism Speaks
FX This research was supported by a ZonMW VIDI Grant (91786327) from The
Netherlands Organization for Scientific Research (NWO) to Dr. Martien
Kas and by EU-AIMS. The research of EU-AIMS receives support from the
Innovative Medicines Initiative Joint Undertaking under Grant agreement
no. 115300, resources of which are composed of financial contribution
from the European Union's Seventh Framework Programme (FP7/2007-2013),
from the EFPIA companies in kind contribution and from Autism Speaks.
CR Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
Birrell JM, 2000, J NEUROSCI, V20, P4320
Bissonette GB, 2008, J NEUROSCI, V28, P11124, DOI 10.1523/JNEUROSCI.2820-08.2008
Blanchard DC, 2012, NEUROSCI BIOBEHAV R, V36, P285, DOI 10.1016/j.neubiorev.2011.06.008
Bolton PF, 2012, J AM ACAD CHILD PSY, V51, P249, DOI 10.1016/j.jaac.2011.12.009
Brigman JL, 2012, PHYSIOL BEHAV, V107, P666, DOI 10.1016/j.physbeh.2011.12.024
Bruining H, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010887
Chadman KK, 2011, PHARMACOL BIOCHEM BE, V97, P586, DOI 10.1016/j.pbb.2010.09.012
Clapcote SJ, 2006, GENETICS, V173, P2407, DOI 10.1534/genetics.106.060749
Colacicco G, 2002, BEHAV BRAIN RES, V132, P95, DOI 10.1016/S0166-4328(01)00391-6
Crawley JN, 1999, BRAIN RES, V835, P18, DOI 10.1016/S0006-8993(98)01258-X
Cullen Kathryn, 2011, Clin Schizophr Relat Psychoses, V4, P229, DOI 10.3371/CSRP.4.4.3
Deboer MD, 2011, PEDIATR RES, V69, P34, DOI 10.1203/PDR.0b013e3181ffee6c
Defensor EB, 2011, BEHAV BRAIN RES, V217, P302, DOI 10.1016/j.bbr.2010.10.033
Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925
Flores CG, 2011, J NEURODEV DISORD, V3, P316, DOI 10.1007/s11689-011-9094-3
Fountain C, 2012, PEDIATRICS, V129, pE1112, DOI 10.1542/peds.2011-1601
Garner JP, 2006, BEHAV BRAIN RES, V173, P53, DOI 10.1016/j.bbr.2006.06.002
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Gonzalez-Ortega I, 2012, PSYCHIAT RES
Gould TD, 2006, GENES BRAIN BEHAV, V5, P113, DOI 10.1111/j.1601-183X.2005.00186
Jahshan C, 2010, NEUROPSYCHOLOGY, V24, P109, DOI 10.1037/a0016791
Johnson S, 2011, DEV NEUROPSYCHOL, V36, P74, DOI 10.1080/87565641.2011.540541
Kalueff AV, 2008, BEHAV BRAIN RES, V188, P243, DOI 10.1016/j.bbr.2007.11.011
Kas M.J, 2011, SCI TRANSL MED, V3, P1
Kas MJH, 2008, BEHAV NEUROSCI, V122, P769, DOI 10.1037/0735-7044.122.4.769
Kas MJH, 2007, MOL PSYCHIATR, V12, P324, DOI 10.1038/sj.mp.4001979
Kvajo M, 2008, P NATL ACAD SCI USA, V105, P7076, DOI 10.1073/pnas.0802615105
Laarakker MC, 2008, BEHAV GENET, V38, P159, DOI 10.1007/s10519-007-9188-6
Lalonde R, 2005, BEHAV BRAIN RES, V157, P91, DOI 10.1016/j.bbr.2004.06.020
Langen M, 2011, NEUROSCI BIOBEHAV R, V35, P345, DOI 10.1016/j.neubiorev.2010.02.004
LaPorte JL, 2008, BEHAV PHARMACOL, V19, P377, DOI 10.1097/FBP.0b013e32830dc09b
McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
Moss J, 2009, J AUTISM DEV DISORD, V39, P572, DOI 10.1007/s10803-008-0655-6
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Paus T, 2008, NAT REV NEUROSCI, V9, P947, DOI 10.1038/nrn2513
Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x
Pingault JB, 2012, MOL PSYCHIAT
Pingault JB, 2011, AM J PSYCHIAT, V168, P1164, DOI 10.1176/appi.ajp.2011.10121732
Pobbe RLH, 2011, BEHAV BRAIN RES, V216, P446, DOI 10.1016/j.bbr.2010.08.039
Poirier M, 2011, J ABNORM PSYCHOL, V120, P247, DOI 10.1037/a0022298
Ricceri L, 2007, BEHAV BRAIN RES, V176, P40, DOI 10.1016/j.bbr.2006.08.024
Rogers DC, 1999, BEHAV BRAIN RES, V105, P207, DOI 10.1016/S0166-4328(99)00072-8
Ryan BC, 2010, BEHAV BRAIN RES, V208, P178, DOI 10.1016/j.bbr.2009.11.031
Sayers N, 2011, J INTELL DISABIL RES, V55, P699, DOI 10.1111/j.1365-2788.2010.01370.x
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Silverman JL, 2010, NEUROSCIENCE, V171, P1197, DOI 10.1016/j.neuroscience.2010.09.059
Tanimura Y, 2011, INT J DEV NEUROSCI, V29, P461, DOI 10.1016/j.ijdevneu.2011.02.004
Tecott LH, 2004, NAT NEUROSCI, V7, P462, DOI 10.1038/nn1225
Thomas MSC, 2009, J SPEECH LANG HEAR R, V52, P336, DOI 10.1044/1092-4388(2009/07-0144)
Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
Wittchen HU, 2011, EUR NEUROPSYCHOPHARM, V21, P655, DOI 10.1016/j.euroneuro.2011.07.018
Zhou YX, 2007, J ENDOCRINOL, V193, P405, DOI 10.1677/joe.1.07049
NR 53
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD JUN
PY 2014
VL 24
IS 6
BP 945
EP 954
DI 10.1016/j.euroneuro.2014.01.013
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AI4YF
UT WOS:000336871900013
PM 24491952
ER
PT J
AU Hodgson, NW
Waly, MI
Al-Farsi, YM
Al-Sharbati, MM
Al-Farsi, O
Ali, A
Ouhtit, A
Zang, TZ
Zhou, ZS
Deth, RC
AF Hodgson, Nathaniel W.
Waly, Mostafa I.
Al-Farsi, Yahya M.
Al-Sharbati, Marwan M.
Al-Farsi, Omar
Ali, Amanat
Ouhtit, Allal
Zang, Tianzhu
Zhou, Zhaohui Sunny
Deth, Richard C.
TI Decreased glutathione and elevated hair mercury levels are associated
with nutritional deficiency-based autism in Oman
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Cobalamin; epigenetic; folic acid; homocysteine thiolactone; methionine
synthase; neurodevelopment
ID ONE-CARBON METABOLISM; OXIDATIVE STRESS; SPECTRUM DISORDERS; DNA
METHYLATION; GASTROINTESTINAL SYMPTOMS; HOMOCYSTEINE THIOLACTONE;
PERIPHERAL-BLOOD; NERVOUS-SYSTEM; HEAVY-METALS; CHILDREN
AB Genetic, nutrition, and environmental factors have each been implicated as sources of risk for autism. Oxidative stress, including low plasma levels of the antioxidant glutathione, has been reported by numerous autism studies, which can disrupt methylation-dependent epigenetic regulation of gene expression with neurodevelopmental consequences. We investigated the status of redox and methylation metabolites, as well as the level of protein homocysteinylation and hair mercury levels, in autistic and neurotypical control Omani children, who were previously shown to exhibit significant nutritional deficiencies in serum folate and vitamin B-12. The serum level of glutathione in autistic subjects was significantly below control levels, while levels of homocysteine and S-adenosylhomocysteine were elevated, indicative of oxidative stress and decreased methionine synthase activity. Autistic males had lower glutathione and higher homocysteine levels than females, while homocysteinylation of serum proteins was increased in autistic males but not females. Mercury levels were markedly elevated in the hair of autistic subjects vs. control subjects, consistent with the importance of glutathione for its elimination. Thus, autism in Oman is associated with decreased antioxidant resources and decreased methylation capacity, in conjunction with elevated hair levels of mercury.
C1 [Hodgson, Nathaniel W.; Deth, Richard C.] Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci, Boston, MA 02115 USA.
[Waly, Mostafa I.; Ali, Amanat] Sultan Qaboos Univ, Dept Food Sci & Nutr, Muscat 123, Oman.
[Waly, Mostafa I.] Univ Alexandria, High Inst Publ Hlth, Dept Nutr, Alexandria 165, Egypt.
[Al-Farsi, Yahya M.; Al-Farsi, Omar] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Family Med & Publ Hlth, Muscat 123, Oman.
[Al-Farsi, Yahya M.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA.
[Al-Sharbati, Marwan M.] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Behav Med, Muscat 123, Oman.
[Ouhtit, Allal] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Genet, Muscat 123, Oman.
[Zang, Tianzhu; Zhou, Zhaohui Sunny] Northeastern Univ, Coll Sci, Barnett Inst Chem & Biol Anal, Boston, MA 02115 USA.
RP Deth, RC (reprint author), Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci, Boston, MA 02115 USA.
EM r.deth@neu.edu
FU Internal Grant Fund [IG/AGR/FOOD/10/01]; Strategic Research Fund
[SR/MED/FMCO/11/01]; College of Medicine and Health Sciences; Sultan
Qaboos University; NIH NIGMS [1R01GM101396]; American Heart Association
[09PRE2300071]; Autism Research Institute; College of Agricultural and
Marine Sciences
FX This study was supported by the Internal Grant Fund (IG/AGR/FOOD/10/01),
College of Agricultural and Marine Sciences, Sultan Qaboos University
(to MIW), the Strategic Research Fund offered by His Majesty Sultan of
Oman (SR/MED/FMCO/11/01), College of Medicine and Health Sciences,
Sultan Qaboos University (to YMA), and grants from the NIH NIGMS
(1R01GM101396 to ZSZ), American Heart Association (09PRE2300071 to T.Z.)
and the Autism Research Institute (to RCD).
CR Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P213
Albizzati A, 2012, MINERVA PEDIATR, V64, P27
Al-Farsi YM, 2013, BIOL TRACE ELEM RES, V151, P181, DOI 10.1007/s12011-012-9553-z
Al-Farsi YM, 2013, NUTRITION, V29, P537, DOI 10.1016/j.nut.2012.09.014
Al-Farsi YM, 2011, J AUTISM DEV DISORD, V41, P821, DOI 10.1007/s10803-010-1094-8
Al-Gadani Y, 2009, CLIN BIOCHEM, V42, P1032, DOI 10.1016/j.clinbiochem.2009.03.011
American Psychiatric Association. DI, 1994, DIAGNOSTIC STAT MANU
Amir RE, 1999, NAT GENET, V23, P185
Anderson OS, 2012, J NUTR BIOCHEM, V23, P853, DOI 10.1016/j.jnutbio.2012.03.003
Aschner M, 2010, METAL IONS LIFE SCI, V7, P403, DOI 10.1039/BK9781847551771-00403
Ashwood P, 2004, J CLIN IMMUNOL, V24, P664, DOI 10.1007/s10875-004-6241-6
Bernard S, 2002, MOL PSYCHIATR, V7, pS42, DOI 10.1038/sj.mp.4001177
Blaurock-Busch Eleonor, 2012, Maedica (Buchar), V7, P38
Bose R, 2012, TOXICOL SCI, V130, P383, DOI 10.1093/toxsci/kfs257
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D
Carvalho CML, 2008, J BIOL CHEM, V283, P11913, DOI 10.1074/jbc.M710133200
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Chauhan A, 2012, NEUROCHEM RES, V37, P1681, DOI 10.1007/s11064-012-0775-4
Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
Clarke Donald D., 1999, P637
Deth R, 2008, NEUROTOXICOLOGY, V29, P190, DOI 10.1016/j.neuro.2007.09.010
Essa MM, 2012, BIOL TRACE ELEM RES, V147, P25, DOI 10.1007/s12011-011-9280-x
Farina M, 2013, NEUROCHEM INT, V62, P575, DOI 10.1016/j.neuint.2012.12.006
Feinberg AP, 2010, VIRCHOWS ARCH, V456, P13, DOI 10.1007/s00428-009-0847-2
Fido A, 2005, AUTISM, V9, P290, DOI 10.1177/1362361305053255
Gaita L, 2010, PSYCHIAT RES, V180, P105, DOI 10.1016/j.psychres.2010.04.010
Garrecht M, 2011, TOXICOL ENVIRON CHEM, V93, P1251, DOI 10.1080/02772248.2011.580588
Geier DA, 2009, J NEUROL SCI, V280, P101, DOI 10.1016/j.jns.2008.08.021
Glowacki R, 2004, J BIOL CHEM, V279, P10864, DOI 10.1074/jbc.M313268200
Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
Gonzales ML, 2010, CURR PSYCHIAT REP, V12, P127, DOI 10.1007/s11920-010-0097-7
Goodrich JM, 2013, ENVIRON MOL MUTAGEN, V54, P195, DOI 10.1002/em.21763
Grabrucker Andreas M, 2012, Front Psychiatry, V3, P118, DOI 10.3389/fpsyt.2012.00118
Gu F, 2013, FREE RADICAL BIO MED, V65, P488, DOI 10.1016/j.freeradbiomed.2013.07.021
Hill KE, 2003, J BIOL CHEM, V278, P13640, DOI 10.1074/jbc.M300755200
Hochberg Z, 2011, ENDOCR REV, V32, P159, DOI 10.1210/er.2009-0039
Holmes AS, 2003, INT J TOXICOL, V22, P277, DOI 10.1080/10915810390220054
Jakubowski H, 1997, BIOCHEMISTRY-US, V36, P11077, DOI 10.1021/bi970589n
Jakubowski H, 2007, CLIN CHEM LAB MED, V45, P1704, DOI 10.1515/CCLM.2007.338
Jakubowski H, 2011, ADV CLIN CHEM, V55, P81, DOI 10.1016/B978-0-12-387042-1.00005-8
James SJ, 2013, TRANSL PSYCHIAT, V20133, pe232
James SJ, 2008, J AUTISM DEV DISORD, V38, P1966, DOI 10.1007/s10803-008-0591-5
James SJ, 2004, AM J CLIN NUTR, V80, P1611
James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
Jyonouchi H, 2011, J NEUROIMMUNOL, V238, P73, DOI 10.1016/j.jneuroim.2011.07.001
Lakshman MR, 2006, METABOLISM, V55, P1201, DOI 10.1016/j.metabol.2006.06.001
Landrigan PJ, 2012, ENVIRON HEALTH PERSP, V120, pA258, DOI 10.1289/ehp.1104285
LaSalle JM, 2011, EPIGENETICS-US, V6, P862, DOI 10.4161/epi.6.7.16353
Lertratanangkoon K, 1997, CANCER LETT, V120, P149, DOI 10.1016/S0304-3835(97)00300-5
Lister R, 2013, SCIENCE, V341, P629, DOI 10.1126/science.1237905
Ludwig ML, 1997, ANNU REV BIOCHEM, V66, P269, DOI 10.1146/annurev.biochem.66.1.269
Lv JW, 2013, J GENET GENOMICS, V40, P339, DOI 10.1016/j.jgg.2013.04.007
MCCONKIEROSELL A, 1993, AM J HUM GENET, V53, P800
Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
Mellen M, 2012, CELL, V151, P1417, DOI 10.1016/j.cell.2012.11.022
Melnyk S, 2012, J AUTISM DEV DISORD, V42, P367, DOI 10.1007/s10803-011-1260-7
Morrow EM, 2010, J AM ACAD CHILD PSY, V49, P1091, DOI 10.1016/j.jaac.2010.08.009
Mostafa GA, 2010, J CHILD NEUROL, V25, P328, DOI 10.1177/0883073809339393
Muratore CR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056927
Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Pardo Carlos A, 2005, Int Rev Psychiatry, V17, P485, DOI 10.1080/02646830500381930
Park Jung-Duck, 2012, J Prev Med Public Health, V45, P344, DOI 10.3961/jpmph.2012.45.6.344
Park LK, 2012, P NUTR SOC, V71, P75, DOI 10.1017/S0029665111003302
Pasca SP, 2009, J CELL MOL MED, V13, P4229, DOI 10.1111/j.1582-4934.2008.00463.x
Pasca SP, 2006, LIFE SCI, V78, P2244, DOI 10.1016/j.lfs.2005.09.040
Pastural E, 2009, PROSTAG LEUKOTR ESS, V81, P253, DOI 10.1016/j.plefa.2009.06.003
Ralston NVC, 2008, NEUROTOXICOLOGY, V29, P802, DOI 10.1016/j.neuro.2008.07.007
Rose S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.61
Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
Roy S, 2012, BRAIN DEV-JPN, V34, P64, DOI 10.1016/j.braindev.2011.01.002
Schafer FQ, 2001, FREE RADICAL BIO MED, V30, P1191, DOI 10.1016/S0891-5849(01)00480-4
Shelton JF, 2012, ENVIRON HEALTH PERSP, V120, P944, DOI 10.1289/ehp.1104553
Steinbrenner H, 2013, ARCH BIOCHEM BIOPHYS, V536, P152, DOI 10.1016/j.abb.2013.02.021
Thatcher KN, 2005, HUM MOL GENET, V14, P785, DOI 10.1093/hmg/ddi073
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Wang T, 2012, HUM MOL GENET, V21, P5500, DOI 10.1093/hmg/dds394
Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
Wong CC, 2013, MOL PSYCHIATR, DOI [10.1038/mp.2013.41, DOI 10.1038/MP.2013.41.]
Yasuda H, 2013, SCI REP-UK, V3, DOI 10.1038/srep01199
Zang TZ, 2009, ANAL CHEM, V81, P9065, DOI 10.1021/ac9017132
NR 83
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JUN
PY 2014
VL 239
IS 6
BP 697
EP 706
DI 10.1177/1535370214527900
PG 10
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AI6GU
UT WOS:000336970900006
PM 24676906
ER
PT J
AU Goh, S
Dong, ZC
Zhang, YD
DiMauro, S
Peterson, BS
AF Goh, Suzanne
Dong, Zhengchao
Zhang, Yudong
DiMauro, Salvatore
Peterson, Bradley S.
TI Mitochondrial Dysfunction as a Neurobiological Subtype of Autism
Spectrum Disorder Evidence From Brain Imaging
SO JAMA PSYCHIATRY
LA English
DT Article
ID MAGNETIC-RESONANCE SPECTROSCOPY; CHILDREN; NEURODEGENERATION;
INDIVIDUALS; INTERVIEW; SCHEDULE; HISTORY; DISEASE; VERSION
AB IMPORTANCE Impaired mitochondrial function impacts many biological processes that depend heavily on energy and metabolism and can lead to a wide range of neurodevelopmental disorders, including autism spectrum disorder (ASD). Although evidence that mitochondrial dysfunction is a biological subtype of ASD has grown in recent years, no study, to our knowledge, has demonstrated evidence of mitochondrial dysfunction in brain tissue in vivo in a large, well-defined sample of individuals with ASD.
OBJECTIVES To assess brain lactate in individuals with ASD and typically developing controls using high-resolution, multiplanar spectroscopic imaging; to map the distribution of lactate in the brains of individuals with ASD; and to assess correlations of elevated brain lactate with age, autism subtype, and intellectual ability.
DESIGN, SETTING, AND PARTICIPANTS Case-control study at Columbia University Medical Center and New York State Psychiatric Institute involving 75 children and adults with ASD and 96 age-and sex-matched, typically developing controls.
MAIN OUTCOMES AND MEASURES Lactate doublets (present or absent) on brain magnetic resonance spectroscopic imaging.
RESULTS Lactate doublets were present at a significantly higher rate in participants with ASD (13%) than controls (1%) (P = .001). In the ASD group, the presence of lactate doublets correlated significantly with age (P = .004) and was detected more often in adults (20%) than in children (6%), though it did not correlate with sex, ASD subtype, intellectual ability, or the Autism Diagnostic Observation Schedule total score or subscores. In those with ASD, lactate was detected most frequently within the cingulate gyrus but it was also present in the subcortical gray matter nuclei, corpus callosum, superior temporal gyrus, and pre- and postcentral gyri.
CONCLUSIONS AND RELEVANCE In vivo brain findings provide evidence for a possible neurobiological subtype of mitochondrial dysfunction in ASD.
C1 [Goh, Suzanne; Dong, Zhengchao; Zhang, Yudong; Peterson, Bradley S.] Columbia Univ Med Ctr, Dept Psychiat, New York, NY 10032 USA.
[Dong, Zhengchao; Zhang, Yudong] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[DiMauro, Salvatore] Columbia Univ Med Ctr, Dept Neurol, New York, NY 10032 USA.
RP Peterson, BS (reprint author), Columbia Univ Med Ctr, Dept Psychiat, 1051 Riverside Dr,Unit 74, New York, NY 10032 USA.
EM bp2014@columbia.edu
RI Zhang, Yudong/I-7633-2013
OI Zhang, Yudong/0000-0002-4870-1493
FU National Institutes of Health [NIMH R01 MH089582]; Tom Klingenstein and
Nancy Perlman Family Fund; Suzanne Crosby Murphy Endowment at Columbia
University
FX This study was made possible by funding from the National Institutes of
Health (grant NIMH R01 MH089582), the Tom Klingenstein and Nancy Perlman
Family Fund, and the Suzanne Crosby Murphy Endowment at Columbia
University.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Beal MF, 2005, ANN NEUROL, V58, P495, DOI 10.1002/ana.20624
Chauhan A, 2011, J NEUROCHEM, V117, P209, DOI 10.1111/j.1471-4159.2011.07189.x
Chow SL, 2005, ARCH DIS CHILD, V90, P1188, DOI 10.1136/adc.2005.075317
Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6
Correia C, 2006, J AUTISM DEV DISORD, V36, P1137, DOI 10.1007/s10803-006-0138-6
Corrigan NM, 2012, J AUTISM DEV DISORD, V42, P105, DOI 10.1007/s10803-011-1216-y
DAGER SR, 1995, AM J PSYCHIAT, V152, P666
Dager SR, 1999, AM J PSYCHIAT, V156, P229
DUYN JH, 1993, RADIOLOGY, V188, P277
Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037
Friedman SD, 2003, NEUROLOGY, V60, P100
Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
Lezi E, 2012, ADV EXP MED BIOL, V942, P269, DOI 10.1007/978-94-007-2869-1_12
Lin DDM, 2003, AM J NEURORADIOL, V24, P33
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Manji H, 2012, NAT REV NEUROSCI, V13, P293, DOI 10.1038/nrn3229
Matsumoto K, 2004, SCIENCE, V303, P969, DOI 10.1126/science.1094733
Modica-Napolitano JS, 2003, ARCH PHARM RES, V26, P951, DOI 10.1007/BF02980205
Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071
Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
Parikh S, 2009, CURR TREAT OPTION N, V11, P414, DOI 10.1007/s11940-009-0046-0
Persico AM, 2013, BEHAV BRAIN RES, V251, P95, DOI 10.1016/j.bbr.2013.06.012
Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
SPITZER RL, 1992, ARCH GEN PSYCHIAT, V49, P624
Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076
Tang GM, 2013, NEUROBIOL DIS, V54, P349, DOI 10.1016/j.nbd.2013.01.006
Wechsler D, 1999, WECHSLER ABBREVIATED
NR 31
TC 11
Z9 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JUN
PY 2014
VL 71
IS 6
BP 665
EP 671
DI 10.1001/jamapsychiatry.2014.179
PG 7
WC Psychiatry
SC Psychiatry
GA AI5NQ
UT WOS:000336915600011
PM 24718932
ER
PT J
AU Kitcharoensakkul, M
Schulz, CG
Kassel, R
Khanna, G
Liang, S
Ngwube, A
Baszis, KW
Hunstad, DA
White, AJ
AF Kitcharoensakkul, Maleewan
Schulz, Christa G.
Kassel, Rachel
Khanna, Geetika
Liang, Shannon
Ngwube, Alexander
Baszis, Kevin W.
Hunstad, David A.
White, Andrew J.
TI Scurvy Revealed by Difficulty Walking Three Cases in Young Children
SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
LA English
DT Article
DE scurvy; osteomyelitis; oral aversion
ID CHILD
AB Scurvy is rare in developed countries but is known to cause lower-extremity pain and refusal to ambulate in children. Since the discovery of the link between scurvy and dietary deficiency of ascorbic acid, there has been a substantial decrease in its prevalence and recognition. Here we describe 3 cases of scurvy in young children presenting with difficulty walking. Only 1 of 3 patients had gingival lesions at the initial presentation. Two cases underwent an extensive evaluation for hematologic and rheumatologic diseases before the diagnosis of scurvy was made. Dietary histories eventually revealed that all 3 patients had sharply limited intake of fruits and vegetables secondary to oral aversion, and 1 patient had autism. Radiographic changes of long bones were observed in all patients. Interestingly, all patients had concomitant vitamin D deficiency. After replacement with vitamin C, all patients recovered and started to walk again with improved leg pain. These clinical manifestations and radiologic findings highlight the importance for rheumatologists to have a higher index of suspicion for scurvy in nonambulatory children.
C1 [Kitcharoensakkul, Maleewan; Schulz, Christa G.; Kassel, Rachel; Liang, Shannon; Ngwube, Alexander; Baszis, Kevin W.; Hunstad, David A.; White, Andrew J.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
[Khanna, Geetika] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA.
RP White, AJ (reprint author), 660 S Euclid Ave,Campus Box 8116, St Louis, MO 63110 USA.
EM white@kids.wustl.edu
CR Carr AC, 1999, AM J CLIN NUTR, V69, P1086
Choi SW, 2007, KOREAN J RADIOL, V8, P443, DOI 10.3348/kjr.2007.8.5.443
Duggan PC, 2007, NEW ENGL J MED, V357, P392
Estienne M, 2011, NEUROL SCI, V32, P1091, DOI 10.1007/s10072-011-0680-7
Fain O, 2005, JOINT BONE SPINE, V72, P124, DOI 10.1016/j.jbspin.2004.01.007
Food and Nutrition Board Institute of Medicine, 2000, VIT C DIET REF INT V, P95
Heymann WR, 2007, J AM ACAD DERMATOL, V57, P358, DOI 10.1016/j.jaad.2007.03.008
Levine M, 1999, JAMA-J AM MED ASSOC, V281, P1415, DOI 10.1001/jama.281.15.1415
Mandl J, 2009, BRIT J PHARMACOL, V157, P1097, DOI 10.1111/j.1476-5381.2009.00282.x
Niwa T, 2012, J PEDIAT HEMATOL ONC, V34, P484, DOI 10.1097/MPH.0b013e318236c519
Popovich D, 2009, J PEDIATR HEALTH CAR, V23, P405, DOI 10.1016/j.pedhc.2008.10.008
Ratanachu-Ek Suntaree, 2003, J Med Assoc Thai, V86 Suppl 3, pS734
Sawyer JR, 2009, AM FAM PHYSICIAN, V79, P215
Shah D, 2011, NELSON TXB PEDIAT, P198
Smith A, 2011, CAN MED ASSOC J, V183, pE752, DOI 10.1503/cmaj.091938
U.S. Centers for Disease Control and Prevention, 2012, 2 NAT REP BIOCH IND
NR 16
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-1608
EI 1536-7355
J9 JCR-J CLIN RHEUMATOL
JI JCR-J. Clin. Rheumatol.
PD JUN
PY 2014
VL 20
IS 4
BP 224
EP 228
DI 10.1097/RHU.0000000000000101
PG 5
WC Rheumatology
SC Rheumatology
GA AI8JN
UT WOS:000337159800010
PM 24847751
ER
PT J
AU Wehman, P
Schall, C
Carr, S
Targett, P
West, M
Cifu, G
AF Wehman, Paul
Schall, Carol
Carr, Staci
Targett, Pam
West, Michael
Cifu, Gabriella
TI Transition From School to Adulthood for Youth With Autism Spectrum
Disorder: What We Know and What We Need to Know
SO JOURNAL OF DISABILITY POLICY STUDIES
LA English
DT Article
DE autism spectrum disorders; transition; educational policy; adolescent;
high school; employment; postsecondary education
ID POSTSECONDARY EDUCATION; YOUNG-ADULTS; INTELLECTUAL DISABILITIES;
SELF-DETERMINATION; PROBLEM BEHAVIOR; STUDENTS; EMPLOYMENT;
INTERVENTIONS; INDIVIDUALS; COLLEGE
AB Youth with autism spectrum disorders (ASD) experience poor outcomes in the areas of independence, employment, and postsecondary education. This article provides a critical review of the key aspects of the transition process and identifies recommendations for policy and practice. The review highlights the literature and explores recommendations across the manifold elements of this transition, including social and psychological development, high school curriculum, work, and college. Five policy recommendations are outlined in the areas of school curriculum, employment development, postsecondary education, inclusion with nondisabled peers, and systematic instruction. Finally, the authors offer recommendations for further research in the areas of social interaction, increased academic and vocational rigor, employment, technology, independence, and postsecondary education.
C1 [Wehman, Paul; Schall, Carol; Carr, Staci; Targett, Pam; West, Michael; Cifu, Gabriella] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
RP Wehman, P (reprint author), Virginia Commonwealth Univ, Div Rehabil Res Director, VCU Autism Ctr Excellence, Med Coll Virginia Campus, Richmond, VA 23284 USA.
EM pwehman@vcu.edu
CR Adamek L, 2011, FOCUS AUTISM DEV DIS, V26, P173, DOI 10.1177/1088357611405041
Attwood T., 2007, COMPLETE GUIDE ASPER
Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268
Barnhill G. P., 2007, FOCUS AUTISM OTHER D, V22, P116, DOI DOI 10.1177/10883576070220020301
Cameto R, 2004, TRANSITION PLANNING
Carter E. W., 2013, LIFE CLASSROOM, P261
Carter EW, 2011, INTELLECT DEV DISAB, V49, P233, DOI 10.1352/1934-9556-49.4.233
Certo NJ, 2008, RES PRACT PERS SEV D, V33, P85
Chiang HM, 2012, J AUTISM DEV DISORD, V42, P685, DOI 10.1007/s10803-011-1297-7
Cimera RE, 2009, AUTISM, V13, P285, DOI 10.1177/1362361309103791
Datson M., 2012, HIGH SCH TRANSITION
Dente C. L., 2012, CHILDREN SCH, V34, P21
Garcia-Villamisar D, 2000, J VOCATIONAL REHABIL, V14, P183
Gentry T., 2010, J VOCATIONAL REHABIL, V32, P101
Goldberg R. J., 2003, LEARNING DISABILITIE, V18, P222, DOI DOI 10.1111/1540-5826.00077
Hart D, 2010, FOCUS AUTISM DEV DIS, V25, P134, DOI 10.1177/1088357610373759
Hendricks DR, 2009, FOCUS AUTISM DEV DIS, V24, P77, DOI 10.1177/1088357608329827
Henninger NA, 2013, AUTISM, V17, P103, DOI 10.1177/1362361312441266
Hewitt LE, 2011, TOP LANG DISORD, V31, P273, DOI 10.1097/TLD.0b013e318227fd19
Horner RH, 2002, J AUTISM DEV DISORD, V32, P423, DOI 10.1023/A:1020593922901
Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
Humphrey N., 2008, J RES SPECIAL ED NEE, V8, P132
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
IWATA BA, 1982, ANAL INTERVEN DEVEL, V2, P3, DOI 10.1016/0270-4684(82)90003-9
Konrad M, 2007, LEARN DISABILITY Q, V30, P89
Landmark L. J., 2010, CAREER DEV EXCEPTION, V33, P165, DOI DOI 10.1177/0885728810376410
Lau S., 2012, J VOCATIONAL REHABIL, V37, P75, DOI [10:3233/JVR-2012-0601, DOI 10.3233/JVR-2012-0601]
Machalicek W, 2007, RES AUTISM SPECT DIS, V1, P229, DOI 10.1016/j.rasd.2006.10.005
Martin J., 2007, CAREER DEV EXCEPTION, V30, P13, DOI 10.1177/08857288070300010101
Mawhood L, 1999, AUTISM INT J RES PRA, V3, P229, DOI DOI 10.1177/1362361399003003003
McDonough J. T., 2010, J VOCATIONAL REHABIL, V32, P81, DOI DOI 10.3233/JVR-2010-0503
Newman L., 2005, HIGH SCH 1 LOOK POST
Newman L., 2007, FACTS NLTS2 SECONDAR
Newman L., 2011, NCSER20123000 US DEP
Newman L., 2011, 20113005 NCSER SRI I
Pawlby SJ, 1997, J ADOLESCENCE, V20, P633, DOI 10.1006/jado.1997.0116
Roberts KD, 2010, FOCUS AUTISM DEV DIS, V25, P158, DOI 10.1177/1088357610371476
Schall C, 2012, PEDIATR CLIN N AM, V59, P189, DOI 10.1016/j.pcl.2011.10.009
Schall C., 2013, LIFE CLASSROOM, P447
Schall C. M., 2010, J VOCATIONAL REHABIL, V32, P109, DOI DOI 10.3233/JVR-2010-0500
Shattuck PT, 2011, ARCH PEDIAT ADOL MED, V165, P141, DOI 10.1001/archpediatrics.2010.279
Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
Shogren KA, 2012, INTELLECT DEV DISAB, V50, P16, DOI 10.1352/1934-9556-50.1.16
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
Test D., 2009, CAREER DEV EXCEPTION, V32, P160, DOI DOI 10.1177/0885728809346960
Test D. W., 2009, CAREER DEV EXCEPTION, V32, P115, DOI [10.1177/0885728809336859, DOI 10.1177/0885728809336859]
Thoma C. A., 2005, CAREER DEV EXCEPTION, V28, P104, DOI 10.1177/08857288050280020101
VanBergeijk E, 2008, J AUTISM DEV DISORD, V38, P1359, DOI 10.1007/s10803-007-0524-8
Wagner M., 2007, 20073006 NCSER
Wehman P, 2009, AUTISM TRANSITION AD
Wehman P., 2012, LECT NARRTC 2012 ANN
Wehman P., 2006, LIFE CLASSROOM TRANS, P41
Wehman P, 2013, J POSIT BEHAV INTERV, V15, P144, DOI 10.1177/1098300712459760
Wehman P., 2013, LIFE CLASSROOM TRANS
Wehman P, 2012, RES PRACT PERS SEV D, V37, P160
Wehmeyer M. L., 2013, LIFE CLASSROOM TRANS, P41
Wehmeyer ML, 2010, EDUC TRAIN AUTISM DE, V45, P475
Westbrook J. D., 2012, CAMPBELL SYSTEMATIC, V5, DOI [10.4073/csr.2012.5, DOI 10.4073/CSR.2012.5]
White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
Zanger D., 2010, FOCUS AUTISM OTHER D, V23, P151
NR 60
TC 3
Z9 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1044-2073
EI 1538-4802
J9 J DISABIL POLICY STU
JI J. Disabil. Policy Stud.
PD JUN
PY 2014
VL 25
IS 1
SI SI
BP 30
EP 40
DI 10.1177/1044207313518071
PG 11
WC Rehabilitation
SC Rehabilitation
GA AI3VA
UT WOS:000336791900004
ER
PT J
AU Chevallier, C
Parish-Morris, J
Tonge, N
Le, L
Miller, J
Schultz, RT
AF Chevallier, Coralie
Parish-Morris, Julia
Tonge, Natasha
Le, Lori
Miller, Judith
Schultz, Robert T.
TI Susceptibility to the Audience Effect Explains Performance Gap Between
Children With and Without Autism in a Theory of Mind Task
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
LA English
DT Article
DE audience effect; autism spectrum disorders; motivation; reputation;
theory of mind
ID SOCIAL FACILITATION; SPECTRUM DISORDERS; INTELLIGENCE; LANGUAGE; OTHERS;
GAME; FACE; COMMUNICATION; IMPAIRMENTS; COMPETENCE
AB Diminished social motivation constitutes one of the core impairments of autism spectrum disorder (ASD) and is thought to have a strong impact on the way individuals with autism respond to the presence of others. In this study, we hypothesized that experimental contexts involving direct interaction with an experimenter might elicit different reactions in children with ASD and thus act as a potential confound in the interpretation of group differences during social cognitive tests. Following classic work in social psychology on the audience effect-wherein individuals act differently when they are being watched in a more or less conscious attempt to enhance their reputation in the eyes of others-we reasoned that social contexts are indeed likely to produce an increase in performance in typically developing (TD) individuals but that children with ASD would be less susceptible to such audience effects. More specifically, we were interested in testing the idea that susceptibility to the audience effect might explain part of the performance gap between children with autism (ASDs) and children without autism in theory of mind (ToM) tasks, which are typically administered by a human experimenter. We tested this hypothesis by comparing performance on a ToM task administered in a social versus a nonsocial setting. We found that ASDs and controls performed similarly when the task was administered using a nonsocial medium. However, control participants outperformed ASDs when an experimenter administered the task. Thus, TD controls demonstrated a relative improvement in performance when in the presence of an experimenter that children with ASD did not. The implications of this diminished audience effect in ASD are discussed.
C1 [Chevallier, Coralie; Parish-Morris, Julia; Tonge, Natasha; Le, Lori; Miller, Judith; Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Parish-Morris, Julia; Schultz, Robert T.] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Parish-Morris, Julia; Schultz, Robert T.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
RP Chevallier, C (reprint author), Ctr Autism Res, Suite 860,3535 Market St, Philadelphia, PA 19104 USA.
EM coralie.chevallier@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
[Anonymous], E PRIM VERS 2 COMP S
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Bateson M, 2006, BIOL LETT-UK, V2, P412, DOI 10.1098/rsbl.2006.0509
BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
Bowman ND, 2013, MEDIA PSYCHOL, V16, P39, DOI 10.1080/15213269.2012.742360
Brunet Eric, 2003, Cogn Neuropsychiatry, V8, P129, DOI 10.1080/13546800244000256
Cage E, 2013, AUTISM RES, V6, P433, DOI 10.1002/aur.1313
CHAPMAN AJ, 1973, J EXP PSYCHOL, V9, P528, DOI 10.1016/0022-1031(73)90035-8
Chevallier C., 2012, DEV PSYCHOL REVISITI, P148
Chevallier C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031107
Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
Chevallier C, 2011, NEUROPSYCHOLOGIA, V49, P507, DOI 10.1016/j.neuropsychologia.2010.11.042
Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
Duckworth AL, 2011, P NATL ACAD SCI USA, V108, P7716, DOI 10.1073/pnas.1018601108
Dufour N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075468
Elliot C. D., 2007, DIFFERENTIAL ABILITY
ERNESTJONES M, 2011, EVOL HUM BEHAV, V32, P172, DOI DOI 10.1016/J.EVOLHUMBEHAV.2010.10.006
Fisher N, 2005, J CHILD PSYCHOL PSYC, V46, P409, DOI 10.1111/j.1469-7610.2004.00371.x
FRITH U, 1994, PHILOS T ROY SOC B, V346, P97, DOI 10.1098/rstb.1994.0133
Frith U., 2013, SCRIPTA VARIA
Haley KJ, 2005, EVOL HUM BEHAV, V26, P245, DOI 10.1016/j.evolhumbehav.2005.01.002
HAPPE FGE, 1993, COGNITION, V48, P101, DOI 10.1016/0010-0277(93)90026-R
HAPPE FGE, 1995, METAPHOR SYMB ACT, V10, P275, DOI 10.1207/s15327868ms1004_3
Huguet P, 1999, J PERS SOC PSYCHOL, V77, P1011, DOI 10.1037//0022-3514.77.5.1011
Izuma K, 2011, P NATL ACAD SCI USA, V108, P17302, DOI 10.1073/pnas.1107038108
Kim EY, 2005, DEV NEUROPSYCHOL, V28, P871, DOI 10.1207/s15326942dn2803_7
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Leary M. R., 2010, SOCIAL MOTIVATION, P37
Leech B. L., 2013, M GRAND CENTR UND SO
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mundy P, 2001, INT REV RES MENT RET, V23, P139
Norbury CF, 2005, BRIT J DEV PSYCHOL, V23, P383, DOI 10.1348/026151005X26732
Peterson CC, 2013, DEVELOPMENTAL SCI, V16, P443, DOI 10.1111/desc.12040
Platania J, 2001, J SOC PSYCHOL, V141, P190
Ponnet KS, 2004, AUTISM, V8, P249, DOI 10.1177/1362361304045214
Revelle W., 1993, ATTENTION SELECTION, P346
Rodebaugh TL, 2004, PSYCHOL ASSESSMENT, V16, P169, DOI 10.1037/1040-3590.16.2.169
Rutter M., 2003, SOCIAL COMMUNICATION
Scheeren AM, 2013, J CHILD PSYCHOL PSYC, V54, P628, DOI 10.1111/jcpp.12007
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Surian L, 2008, HANDBOOK OF THE NEUROSCIENCE OF LANGUAGE, P377, DOI 10.1016/B978-008045352-1.00037-9
Wechsler D, 1950, AM PSYCHOL, V5, P78, DOI 10.1037/h0063112
White S, 2009, CHILD DEV, V80, P1097, DOI 10.1111/j.1467-8624.2009.01319.x
White SJ, 2011, AUTISM RES, V4, P149, DOI 10.1002/aur.174
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
Zajonc R. B., 1965, SOCIAL FACILITATION
NR 55
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-3445
EI 1939-2222
J9 J EXP PSYCHOL GEN
JI J. Exp. Psychol.-Gen.
PD JUN
PY 2014
VL 143
IS 3
BP 972
EP 979
DI 10.1037/a0035483
PG 8
WC Psychology, Experimental
SC Psychology
GA AI3TK
UT WOS:000336786300004
PM 24392710
ER
PT J
AU Ehashi, T
Suzuki, N
Ando, S
Sumida, K
Saito, K
AF Ehashi, Tomo
Suzuki, Noriyuki
Ando, Satoshi
Sumida, Kayo
Saito, Koichi
TI Effects of valproic acid on gene expression during human embryonic stem
cell differentiation into neurons
SO JOURNAL OF TOXICOLOGICAL SCIENCES
LA English
DT Article
DE Embryotoxicity; Embryonic stem cell test; Human embryonic stem cells;
Neural differentiation; Valproic acid; Gene expression
ID IN-UTERO EXPOSURE; DEVELOPMENTAL TOXICITY; ES CELLS;
DOPAMINERGIC-NEURONS; ANTIEPILEPTIC DRUGS; MOLECULAR MARKERS;
BIRTH-DEFECTS; AUTISM; VITRO; PROLIFERATION
AB The widely used antiepileptic drug valproic acid (VPA) is known to exhibit teratogenicity in the form of a failure of the neural tube in humans. Embryonic stem cells (ESCs) are reported to be a promising cell source for evaluating chemical teratogenicity, because they are capable of reproducing embryonic developmental model and enable reduction in the number of experimental animals used. We previously investigated 22 genes for which expressions are altered by teratogens, specifically focusing on neural differentiation of mouse ESCs. In the present study, expressions of the investigated genes were evaluated by quantitative real-time PCR and compared during differentiation of human ESCs into neurons with or without VPA. Under the conditions, almost all gene expressions significantly changed in VPA-containing culture. Specifically, in neural development-related genes such as DCX, ARX, MAP2, and NNAT, more than 2-fold expression was observed. The findings suggest that the genes focused on in this study may help to elucidate the teratogenic effects of VPA and might be a useful tool to analyze embryotoxic potential of chemicals in humans.
C1 [Ehashi, Tomo; Suzuki, Noriyuki; Ando, Satoshi; Sumida, Kayo; Saito, Koichi] Sumitomo Chem Co Ltd, Environm Hlth Sci Lab, Konohana Ku, Osaka 5548558, Japan.
RP Saito, K (reprint author), Sumitomo Chem Co Ltd, Environm Hlth Sci Lab, Konohana Ku, 1-98,Kasugadenaka 3 Chome, Osaka 5548558, Japan.
EM saitok5@sc.sumitomo-chem.co.jp
CR Adler S, 2008, TOXICOL IN VITRO, V22, P200, DOI 10.1016/j.tiv.2007.07.013
BAUMAN M, 1985, NEUROLOGY, V35, P866
CACERES A, 1992, NEURON, V9, P607, DOI 10.1016/0896-6273(92)90025-9
de Jong E, 2011, REPROD TOXICOL, V31, P375, DOI 10.1016/j.reprotox.2010.11.012
Eikel D, 2006, CHEM RES TOXICOL, V19, P272, DOI 10.1021/tx0502241
Eiraku M, 2008, CELL STEM CELL, V3, P519, DOI 10.1016/j.stem.2008.09.002
Eiraku M, 2011, NATURE, V472, P51, DOI 10.1038/nature09941
Friocourt G, 2008, J NEUROSCI, V28, P5794, DOI 10.1523/JNEUROSCI.1067-08.2008
Fu XQ, 2013, J NEUROSCI, V33, P709, DOI 10.1523/JNEUROSCI.4603-12.2013
Genschow E, 2004, ATLA-ALTERN LAB ANIM, V32, P209
Gonzalez-Billault C, 2002, J NEUROSCI RES, V67, P713, DOI 10.1002/jnr.10161
Houle J, 1983, Brain Res, V285, P189
Hsieh J, 2004, P NATL ACAD SCI USA, V101, P16659, DOI 10.1073/pnas.0407643101
Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
Jergil M, 2011, TOXICOL SCI, V121, P328, DOI 10.1093/toxsci/kfr070
Jergil M, 2009, TOXICOL SCI, V108, P132, DOI 10.1093/toxsci/kfp002
Juliandi B, 2012, NEUROSCI RES, V72, P23, DOI 10.1016/j.neures.2011.09.012
Kataoka S, 2013, INT J NEUROPSYCHOPH, V16, P91, DOI 10.1017/S1461145711001714
Kawasaki H, 2000, NEURON, V28, P31, DOI 10.1016/S0896-6273(00)00083-0
Kawasaki H, 2002, P NATL ACAD SCI USA, V99, P1580, DOI 10.1073/pnas.032662199
Kim JH, 2011, TOXICOL SCI, V122, P1, DOI 10.1093/toxsci/kfr088
Meador KJ, 2009, NEW ENGL J MED, V360, P1597, DOI 10.1056/NEJMoa0803531
Meador Kimford J, 2008, Epilepsy Curr, V8, P143, DOI 10.1111/j.1535-7511.2008.00273.x
Menegola E, 2005, BIRTH DEFECTS RES B, V74, P392, DOI 10.1002/bdrb.2005
Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489
Murabe M, 2007, BIOCHEM BIOPH RES CO, V352, P164, DOI 10.1016/j.bbrc.2006.10.189
Nadebaum C, 2011, NEUROLOGY, V76, P719, DOI 10.1212/WNL.0b013e31820d62c7
Nakano T, 2012, CELL STEM CELL, V10, P771, DOI 10.1016/j.stem.2012.05.009
NAU H, 1986, ENVIRON HEALTH PERSP, V70, P113, DOI 10.2307/3430348
Ornoy A, 2009, REPROD TOXICOL, V28, P1, DOI 10.1016/j.reprotox.2009.02.014
Pal R, 2011, J CELL PHYSIOL, V226, P1583, DOI 10.1002/jcp.22484
Pratt T, 2002, J NEUROSCI, V22, P8523
Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2
Roullet FI, 2013, NEUROTOXICOL TERATOL, V36, P47, DOI 10.1016/j.ntt.2013.01.004
Seiler A, 2004, REPROD TOXICOL, V18, P231, DOI 10.1016/j.reprotox.2003.10.015
Shallcross R, 2011, NEUROLOGY, V76, P383, DOI 10.1212/WNL.0b013e3182088297
Spielmann Horst, 1997, In Vitro Toxicology, V10, P119
Suzuki N, 2012, J TOXICOL SCI, V37, P845
Suzuki N, 2011, TOXICOL SCI, V124, P460, DOI 10.1093/toxsci/kfr250
Suzuki N, 2011, J TOXICOL SCI, V36, P569
Theunissen PT, 2012, TOXICOL SCI, V125, P430, DOI 10.1093/toxsci/kfr293
Umka J, 2010, NEUROSCIENCE, V166, P15, DOI 10.1016/j.neuroscience.2009.11.073
Werler MM, 2011, ANN EPIDEMIOL, V21, P842, DOI 10.1016/j.annepidem.2011.08.002
WIJNHOLDS J, 1995, DEV BIOL, V171, P73, DOI 10.1006/dbio.1995.1261
NR 44
TC 0
Z9 0
PU JAPANESE SOC TOXICOLOGICAL SCIENCES
PI TOKYO
PA INTERNATIONAL MEDICAL INFORMATION CENTER, SHINANOMACHI RENGAKAN, 35
SHINANO-MACHI, SHINJUKU-KU, TOKYO, 160-0016, JAPAN
SN 0388-1350
EI 1880-3989
J9 J TOXICOL SCI
JI J. Toxicol. Sci.
PD JUN
PY 2014
VL 39
IS 3
BP 383
EP 390
PG 8
WC Toxicology
SC Toxicology
GA AI7KL
UT WOS:000337069200002
PM 24849673
ER
PT J
AU Nuttle, X
Itsara, A
Shendure, J
Eichler, EE
AF Nuttle, Xander
Itsara, Andy
Shendure, Jay
Eichler, Evan E.
TI Resolving genomic disorder-associated breakpoints within segmental DNA
duplications using massively parallel sequencing
SO NATURE PROTOCOLS
LA English
DT Article
ID COPY-NUMBER VARIATION; HUMAN Y-CHROMOSOME; STRUCTURAL VARIATION; GENES;
MAPS; REARRANGEMENTS; HYBRIDIZATION; DISEASE; REGIONS
AB The most common recurrent copy-number variants associated with autism, developmental delay and epilepsy are flanked by segmental duplications. Complete genetic characterization of these events is challenging because their breakpoints often occur within high-identity, copy-number polymorphic paralogous sequences that cannot be specifically assayed using hybridization-based methods. Here we provide a protocol for breakpoint resolution with sequence-level precision. Massively parallel sequencing is performed on libraries generated from haplotype-resolved chromosomes, genomic DNA or molecular inversion probe (MIP)-captured breakpoint-informative regions harboring paralog-distinguishing variants. Quantification of sequencing depth over informative sites enables breakpoint localization, typically within several kilobases to tens of kilobases. Depending on the approach used, the sequencing platform, and the accuracy and completeness of the reference genome sequence, this protocol takes from a few days to several months to complete. Once established for a specific genomic disorder, it is possible to process thousands of DNA samples within as little as 3-4 weeks.
C1 [Nuttle, Xander; Itsara, Andy; Shendure, Jay; Eichler, Evan E.] Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA.
[Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Sch Med, Seattle, WA 98195 USA.
RP Eichler, EE (reprint author), Univ Washington, Dept Genome Sci, Sch Med, Seattle, WA 98195 USA.
EM eee@gs.washington.edu
FU National Science Foundation Graduate Research Fellowship [DGE-1256082];
US National Institutes of Health [HG004120, HG002385]
FX We thank J. Huddleston for assistance in testing analysis software and
preparing it for public access; P. Sudmant for analyzing the number of
SUNKs in windows across the reference genome; and T. Brown for
assistance with manuscript preparation. X. N. is supported by a National
Science Foundation Graduate Research Fellowship under grant no. DGE-
1256082. This work was supported by US National Institutes of Health
grants HG004120 and HG002385 to E. E. E. E. E. E. is an investigator of
the Howard Hughes Medical Institute.
CR Alkan C, 2009, NAT GENET, V41, P1061, DOI 10.1038/ng.437
Bailey JA, 2001, GENOME RES, V11, P1005, DOI 10.1101/gr.GR-1871R
Bovee D, 2008, NAT GENET, V40, P96, DOI 10.1038/ng.2007.34
Broman KW, 1998, AM J HUM GENET, V63, P861, DOI 10.1086/302011
Carlson C, 1997, AM J HUM GENET, V61, P620, DOI 10.1086/515508
Chin CS, 2013, NAT METHODS, V10, P563, DOI [10.1038/nmeth.2474, 10.1038/NMETH.2474]
Dennis MY, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.033
Estivill X, 2002, HUM MOL GENET, V11, P1987, DOI 10.1093/hmg/11.17.1987
Fredman D, 2004, NAT GENET, V36, P861, DOI 10.1038/ng1401
Genovese G, 2013, NAT GENET, V45, P406, DOI 10.1038/ng.2565
Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
Highsmith W.E., 2007, CURR PROT HUM GENET, V3, P36
Horvath JE, 2000, GENOME RES, V10, P839, DOI 10.1101/gr.10.6.839
Inoue K, 2002, ANNU REV GENOM HUM G, V3, P199, DOI 10.1146/annurev.genom.3.032802.120023
Itsara A, 2012, AM J HUM GENET, V90, P599, DOI 10.1016/j.ajhg.2012.02.013
Kidd JM, 2010, NAT METHODS, V7, P365, DOI 10.1038/NMETH.1451
Kitzman JO, 2011, NAT BIOTECHNOL, V29, P59, DOI 10.1038/nbt.1740
Korbel JO, 2007, SCIENCE, V318, P420, DOI 10.1126/science.1149504
LUPSKI JR, 1991, CELL, V66, P219, DOI 10.1016/0092-8674(91)90613-4
Mills RE, 2011, NATURE, V470, P59, DOI 10.1038/nature09708
Nuttle X, 2013, NAT METHODS, V10, P903, DOI [10.1038/nmeth.2572, 10.1038/NMETH.2572]
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Peters BA, 2012, NATURE, V487, P190, DOI 10.1038/nature11236
Pinkel D., 1999, US Patent, Patent No. [5,976,790, 5976790]
Porreca GJ, 2007, NAT METHODS, V4, P931, DOI 10.1038/NMETH1110
Renshaw Mark A, 2013, Methods Mol Biol, V1006, P181, DOI 10.1007/978-1-62703-389-3_13
Sahoo T, 2008, NAT GENET, V40, P719, DOI 10.1038/ng.158
Saxena R, 2000, GENOMICS, V67, P256, DOI 10.1006/geno.2000.6260
Sharp AJ, 2005, AM J HUM GENET, V77, P78, DOI 10.1086/431652
Stankiewicz P, 2002, TRENDS GENET, V18, P74, DOI 10.1016/S0168-9525(02)02592-1
Stankiewicz P, 2010, ANNU REV MED, V61, P437, DOI 10.1146/annurev-med-100708-204735
Sudmant PH, 2010, SCIENCE, V330, P641, DOI 10.1126/science.1197005
Tilford CA, 2001, NATURE, V409, P943, DOI 10.1038/35057170
Turner EH, 2009, NAT METHODS, V6, P315, DOI 10.1038/nmeth.f.248
Tuzun E, 2004, GENOME RES, V14, P493, DOI 10.1101/gr.1907504
van den Ijssel Paul, 2007, V396, P207
Wang NJ, 2004, AM J HUM GENET, V75, P267, DOI 10.1086/422854
Zody MC, 2008, NAT GENET, V40, P1076, DOI 10.1038/ng.193
NR 38
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1754-2189
EI 1750-2799
J9 NAT PROTOC
JI Nat. Protoc.
PD JUN
PY 2014
VL 9
IS 6
BP 1496
EP 1513
DI 10.1038/nprot.2014.096
PG 18
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA AI8FS
UT WOS:000337145800021
PM 24874815
ER
PT J
AU Ferrari, V
Smeraldi, E
Bottero, G
Politi, E
AF Ferrari, Valentina
Smeraldi, Enrico
Bottero, Giampiero
Politi, Ernestina
TI Addiction and empathy: a preliminary analysis
SO NEUROLOGICAL SCIENCES
LA English
DT Article
DE Social cognition; Empathy; Addiction; Neurorehabilitation
ID ALCOHOL-DEPENDENT PATIENTS; SUBSTANCE-ABUSE TREATMENT; HIGH-FUNCTIONING
AUTISM; ASPERGER-SYNDROME; SOCIAL COGNITION; MIND IMPAIRMENTS; ACQUIRED
THEORY; SCHIZOPHRENIA; QUOTIENT; BRAIN
AB Addicted patients show impaired social functioning. Chronic drug consumption may lead to impairments in decoding empathic cues. The aim of the study is to explore empathy abilities in addicted patients and the hypothesis of a differential impairment between affective and cognitive empathy. 62 addicted patients and 40 healthy volunteers were evaluated using the empathy quotient (EQ) and its subscales cognitive empathy (factor 1), emotional empathy (factor 2), social skills (factor 3). Patients scored statistically significantly lower than controls in EQ total score, in particular in factor 2. No difference was found in factor 1 and in factor 3. Consistent with previous findings, our study suggests specific impairment in emotional empathy combined with preserved cognitive empathy. These findings show important clinical implication in the development of specific rehabilitative programmes for the empowerment of empathy abilities and interpersonal skills that constitute important components in the prevention of relapse.
C1 [Ferrari, Valentina; Smeraldi, Enrico; Bottero, Giampiero; Politi, Ernestina] Ist Sci San Raffaele, Dept Neuropsychiat Sci, I-20132 Milan, Italy.
[Ferrari, Valentina; Smeraldi, Enrico; Bottero, Giampiero; Politi, Ernestina] Univ Vita Salute San Raffaele, Milan, Italy.
RP Politi, E (reprint author), Ist Sci San Raffaele, Dept Neuropsychiat Sci, I-20132 Milan, Italy.
EM ferrari.valentina@hsr.it; politi.ernestina@hsr.it
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baron-Cohen S, 2011, ZERO DEGRESS EMPATHY
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Bartek J K, 1999, Nurs Diagn, V10, P158
BILDER RM, 1992, SCHIZOPHRENIA BULL, V18, P437
Bornhofen C, 2008, NEUROPSYCHOL REHABIL, V18, P22, DOI 10.1080/09602010601061213
Canessa N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042347
Chakrabarti B, 2006, PROG BRAIN RES, V156, P403, DOI 10.1016/S0079-6123(06)56022-4
Combs DR, 2007, SCHIZOPHR RES, V91, P112, DOI 10.1016/j.schres.2006.12.010
Dethier M, 2012, PSYCHOL ADDICT BEHAV, V26, P371, DOI 10.1037/a0028673
Frommann N, 2003, PSYCHIAT RES, V117, P281, DOI 10.1016/S0165-1781(03)00039-8
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Goldstein RZ, 2009, TRENDS COGN SCI, V13, P372, DOI 10.1016/j.tics.2009.06.004
Happe F, 1999, COGNITION, V70, P211, DOI 10.1016/S0010-0277(99)00005-0
Harari H, 2010, PSYCHIAT RES, V175, P277, DOI 10.1016/j.psychres.2009.03.002
Karno MP, 2004, J STUD ALCOHOL, V65, P501
Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
Marlatt GA, 1996, ADDICTION, V91, pS37, DOI 10.1111/j.1360-0443.1996.tb02326.x
Martinotti G, 2009, AM J ADDICTION, V18, P157, DOI 10.1080/10550490802544391
Maurage P, 2011, ALCOHOL CLIN EXP RES, V35, P1662, DOI 10.1111/j.1530-0277.2011.01512.x
MCCOWN W, 1989, BRIT J ADDICT, V84, P391
MCCOWN W, 1990, BRIT J ADDICT, V85, P635
McDonald S, 2008, ARCH PHYS MED REHAB, V89, P1648, DOI 10.1016/j.apmr.2008.02.029
Muncer SJ, 2006, PERS INDIV DIFFER, V40, P1111, DOI 10.1016/j.paid.2005.09.020
PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
REILLY PM, 1994, J PSYCHOACTIVE DRUGS, V26, P401
Russell TA, 2006, BRIT J CLIN PSYCHOL, V45, P579, DOI 10.1348/014466505X90866
Shamay-Tsoory S, 2009, J NEUROPSYCH CLIN N, V21, P59, DOI 10.1176/appi.neuropsych.21.1.59
Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
Stone VE, 2003, NEUROPSYCHOLOGIA, V41, P209, DOI 10.1016/S0028-3932(02)00151-3
Van Overwalle F, 2009, HUM BRAIN MAPP, V30, P829, DOI 10.1002/hbm.20547
Witkiewitz K, 2009, J CONSULT CLIN PSYCH, V77, P633, DOI 10.1037/a0015647
NR 32
TC 0
Z9 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1590-1874
EI 1590-3478
J9 NEUROL SCI
JI Neurol. Sci.
PD JUN
PY 2014
VL 35
IS 6
BP 855
EP 859
DI 10.1007/s10072-013-1611-6
PG 5
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AI4BM
UT WOS:000336810500006
PM 24379106
ER
PT J
AU Wiggins, JL
Swartz, JR
Martin, DM
Lord, C
Monk, CS
AF Wiggins, Jillian Lee
Swartz, Johnna R.
Martin, Donna M.
Lord, Catherine
Monk, Christopher S.
TI Serotonin transporter genotype impacts amygdala habituation in youth
with autism spectrum disorders
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE functional MRI; serotonin transporter gene; autism; amygdala;
habituation; face
ID FUNCTIONAL CONNECTIVITY; 5-HTTLPR GENOTYPE; EMOTIONAL FACES; NEURAL
CIRCUITRY; DECISION-MAKING; SOCIAL BRAIN; ADOLESCENTS; CHILDREN; GAZE;
ACTIVATION
AB Failure of the amygdala to habituate, or decrease response intensity, to repeatedly presented faces may be one mechanism by which individuals with autism spectrum disorders (ASD) develop and maintain social symptoms. However, genetic influences on habituation in ASD have not been examined. We hypothesized that serotonin transporter-linked promoter region (5-HTTLPR) genotype affects change in amygdala response to repeated sad faces differently in individuals with ASD vs healthy controls. Forty-four youth with ASD and 65 controls aged 8-19 years were genotyped and underwent an event-related functional magnetic resonance imaging scan where they identified the gender of emotional faces presented for 250 ms. The first half of the run was compared with the second half to assess habituation. 5-HTTLPR genotype influences amygdala habituation to sad faces differently for individuals with ASD vs controls. The genotype-by-diagnosis-by-run half interaction was driven by individuals with ASD and low expressing genotypes (S/S, S/L-G and L-G/L-G), who trended toward sensitization (increase in amygdala activation) and whose habituation scores significantly differed from individuals with ASD and higher expressing genotypes (L-A/L-A, S/L-A and L-A/L-G) as well as controls with low expressing genotypes. Our results show that amygdala response to social stimuli in ASD, which may contribute to social symptoms, is genetically influenced.
C1 [Wiggins, Jillian Lee; Swartz, Johnna R.; Monk, Christopher S.] Univ Michigan, Dept Psychol, Ann Arbor, MI USA.
[Martin, Donna M.] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
[Martin, Donna M.; Monk, Christopher S.] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA.
[Martin, Donna M.] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
[Lord, Catherine] Weill Cornell Med Coll, Dept Psychiat, New York, NY USA.
[Monk, Christopher S.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
[Monk, Christopher S.] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
RP Wiggins, JL (reprint author), 530 Church St, Ann Arbor, MI 48109 USA.
EM leejilli@umich.edu
RI Monk, Christopher/J-1805-2014
FU Autism Speaks Predoctoral Fellowship [4773, 2573]; Michigan Institute
for Clinical Health Research Predoctoral Fellowship [UL1RR024986];
National Institutes of Health [R01NS54784, R01DC009410, U19HD35482,
MH066496]
FX We thank our research assistants and are grateful to the families for
participating. This work was supported by an Autism Speaks Predoctoral
Fellowship (4773 to J.L.W.) and grant (2573 to C.S.M.); Michigan
Institute for Clinical Health Research Predoctoral Fellowship
(UL1RR024986 to J.L.W.) and National Institutes of Health grants
(R01NS54784 and R01DC009410 to D.M.M. and U19HD35482 and MH066496 to
C.L.). C.L. receives royalties from the publisher of diagnostic
instruments used on participants. All profits are given to charity.
Other authors declare no conflict of interest.
CR Adolphs R, 2010, ANN NY ACAD SCI, V1191, P42, DOI 10.1111/j.1749-6632.2010.05445.x
Battaglia M., 2011, DEPRESS ANXIETY, V29, P54
Belsky J, 2009, MOL PSYCHIATR, V14, P746, DOI 10.1038/mp.2009.44
Benjet C, 2010, J CHILD PSYCHOL PSYC, V51, P173, DOI 10.1111/j.1469-7610.2009.02149.x
Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148
Cicchetti D, 2007, DEV PSYCHOPATHOL, V19, P1161, DOI 10.1017/S0954579407000600
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dannlowski U, 2010, NEUROIMAGE, V53, P893, DOI 10.1016/j.neuroimage.2009.11.073
Fischer H, 2003, BRAIN RES BULL, V59, P387, DOI 10.1016/S0361-9230(02)00940-1
Glover GH, 2001, MAGNET RESON MED, V46, P515, DOI 10.1002/mrm.1222
Herry C, 2007, J NEUROSCI, V27, P5958, DOI 10.1523/JNEUROSCI.5218-06.2007
HOLM S, 1979, SCAND J STAT, V6, P65
Hsu M, 2005, SCIENCE, V310, P1680, DOI 10.1126/science.1115327
Hu XZ, 2006, AM J HUM GENET, V78, P815, DOI 10.1086/503850
Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
Kleinhans NM, 2009, AM J PSYCHIAT, V166, P467, DOI 10.1176/appi.ajp.2008.07101681
Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037
Kliemann D, 2012, J NEUROSCI, V32, P9469, DOI 10.1523/JNEUROSCI.5294-11.2012
Kliemann D, 2010, J NEUROSCI, V30, P12281, DOI 10.1523/JNEUROSCI.0688-10.2010
Lonsdorf TB, 2011, BIOL PSYCHOL, V87, P106, DOI 10.1016/j.biopsycho.2011.02.014
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Maldjian J., 2002, NEUROIMAGE, V19, P1233
Meltzer C. C., 2009, CEREB CORTEX, V19, P2499
Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085
Murphy SE, 2013, MOL PSYCHIATR, V18, P512, DOI 10.1038/mp.2012.19
Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
Rankin CH, 2009, NEUROBIOL LEARN MEM, V92, P135, DOI 10.1016/j.nlm.2008.09.012
Roiser JP, 2009, J NEUROSCI, V29, P5985, DOI 10.1523/JNEUROSCI.0407-09.2009
Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3
Surguladze SA, 2008, GENES BRAIN BEHAV, V7, P543, DOI 10.1111/j.1601-183X.2008.00390.x
Swartz JR, 2013, J AM ACAD CHILD PSY, V52, P84, DOI 10.1016/j.jaac.2012.10.012
Thomason ME, 2010, BIOL PSYCHOL, V85, P38, DOI 10.1016/j.biopsycho.2010.04.009
Tottenham N, 2009, PSYCHIAT RES, V168, P242, DOI 10.1016/j.psychres.2008.05.006
Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
Volkmar FR, 2011, DEV PSYCHOBIOL, V53, P428, DOI 10.1002/dev.20556
Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Weng SJ, 2011, J CHILD PSYCHOL PSYC, V52, P296, DOI 10.1111/j.1469-7610.2010.02317.x
Wiggins JL, 2012, NEUROIMAGE, V59, P2760, DOI 10.1016/j.neuroimage.2011.10.030
Wiggins JL, 2011, BRAIN RES, V1380, P187, DOI 10.1016/j.brainres.2010.10.102
Worsley KJ, 1996, HUM BRAIN MAPP, V4, P58, DOI 10.1002/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O
NR 44
TC 1
Z9 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD JUN
PY 2014
VL 9
IS 6
BP 832
EP 838
DI 10.1093/scan/nst039
PG 7
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AI7MU
UT WOS:000337076600013
PM 23526151
ER
PT J
AU Li, XL
Qu, FQ
Xie, WJ
Wang, FL
Liu, HM
Song, SH
Chen, TT
Zhang, Y
Zhu, S
Wang, Y
Guo, CX
Tang, TS
AF Li, Xiaoling
Qu, Fengqin
Xie, Wenjuan
Wang, Fengli
Liu, Hongmei
Song, Shuhui
Chen, Tingting
Zhang, Yang
Zhu, Shu
Wang, Yun
Guo, Caixia
Tang, Tie-Shan
TI Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After
Intermittent Neonatal Administration of Thimerosal
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE thimerosal; transcriptomic analyses; anterior pituitary; hormone;
neurotoxicity; autistic disorder
ID AUTISM SPECTRUM DISORDERS; LONG-TERM POTENTIATION; PERVASIVE
DEVELOPMENTAL DISORDERS; NEURODEVELOPMENTAL DISORDERS; CONTAINING
VACCINES; PREFRONTAL CORTEX; CHILDHOOD VACCINES; UNITED-STATES; MERCURY;
CHILDREN
AB Thimerosal is a vaccine antimicrobial preservative which has long been suspected an iatrogenic factor possibly contributing to neurodevelopmental disorders including autism. The association between infant vaccine thimerosal exposure and autism remains an open question. Although thimerosal has been removed from mandatory childhood vaccines in the United States, thimerosal-preserved vaccines are still widely used outside of the United States especially in developing countries. Notably, thimerosal-containing vaccines are being given to the newborns within the first 12-24 h after birth in some countries. To examine the possible neurotoxic effects of early neonatal exposure to a higher level of thimerosal, FVB mice were subcutaneously injected with thimerosal-mercury at a dose which is 20x higher than that used for regular Chinese infant immunization during the first 4 months of life. Thimerosal-treated mice exhibited neural development delay, social interaction deficiency, and inclination of depression. Apparent neuropathological changes were also observed in adult mice neonatally treated with thimerosal. High-throughput RNA sequencing of autistic-behaved mice brains revealed the alternation of a number of canonical pathways involving neuronal development, neuronal synaptic function, and the dysregulation of endocrine system. Intriguingly, the elevation of anterior pituitary secreting hormones occurred exclusively in male but not in female thimerosal-treated mice, demonstrating for the first time the gender bias of thimerosal-mercury toxicity with regard to endocrine system. Our results indicate that higher dose of neonatal thimerosal-mercury (20x higher than that used in human) is capable of inducing long-lasting substantial dysregulation of neurodevelopment, synaptic function, and endocrine system, which could be the causal involvements of autistic-like behavior in mice.
C1 [Li, Xiaoling; Qu, Fengqin; Xie, Wenjuan; Wang, Fengli; Liu, Hongmei; Zhang, Yang; Zhu, Shu; Wang, Yun; Tang, Tie-Shan] Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China.
[Song, Shuhui; Chen, Tingting; Guo, Caixia] Chinese Acad Sci, Beijing Inst Genom, Ctr Genome Variat & Precis Biomed, Beijing 100029, Peoples R China.
RP Tang, TS (reprint author), Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, 1 Beichen West Rd, Beijing 100101, Peoples R China.
EM tangtsh@ioz.ac.cn
FU National Basic Research Program of China [2011CB965003, 2012CB944702,
2011CB944302]; National Natural Science Foundation of China [81371415,
81300982, 31170730]; CAS/SAFEA; CAS
FX National Basic Research Program of China (2011CB965003, 2012CB944702,
2011CB944302); National Natural Science Foundation of China (81371415,
81300982, 31170730); CAS/SAFEA International Partnership Program for
Creative Research Teams; One-Hundred-Talent Program of CAS (to C.G.).
CR [Anonymous], 1999, PEDIATRICS 1, V104, P568
Aprea J, 2013, EMBO J, V32, P3145, DOI 10.1038/emboj.2013.245
Araghi-Niknam M, 2003, CELL MOL NEUROBIOL, V23, P945, DOI 10.1023/B:CEMN.0000005322.27203.73
Arias-Carrion O, 2007, ACTA NEUROBIOL EXP, V67, P481
Ball LK, 2001, PEDIATRICS, V107, P1147, DOI 10.1542/peds.107.5.1147
Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
Berman RF, 2008, TOXICOL SCI, V101, P294, DOI 10.1093/toxsci/kfm265
Bernard S, 2001, MED HYPOTHESES, V56, P462, DOI 10.1054/mehy.2000.1281
Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419
Blaxill MF, 2004, MED HYPOTHESES, V62, P788, DOI 10.1016/j.mehy.2003.11.033
Bultynck G, 2004, BIOCHEM J, V381, P87, DOI 10.1042/BJ20040072
Centers for Disease Control and Prevention, 1999, MMWR-MORBID MORTAL W, V48, P563
Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
Dallman MF, 2004, ANN NY ACAD SCI, V1018, P141, DOI 10.1196/annals.1296.017
Dorea JG, 2007, AM J PERINAT, V24, P387, DOI 10.1055/s-2007-982074
Dorea JG, 2009, AM J PERINAT, V26, P523, DOI 10.1055/s-0029-1215431
Gallagher CM, 2010, J TOXICOL ENV HEAL A, V73, P1665, DOI 10.1080/15287394.2010.519317
Geier David A, 2003, Pediatr Rehabil, V6, P97, DOI 10.1080/1363849031000139315
Geier D. A., 2004, MED SCI MONITOR, V10, pPI33
Geier DA, 2005, MED SCI MONITOR, V11, pCR160
Geier DA, 2006, NEUROENDOCRINOL LETT, V27, P401
Geier DA, 2006, MED SCI MONITOR, V12, pCR231
Gerra G, 2000, NEUROPSYCHOBIOLOGY, V42, P82, DOI 10.1159/000026677
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Gilbert SJ, 2008, NEUROPSYCHOLOGIA, V46, P2281, DOI 10.1016/j.neuropsychologia.2008.03.025
Guzowski JF, 2000, J NEUROSCI, V20, P3993
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Heron J, 2004, PEDIATRICS, V114, P577, DOI 10.1542/peds.2003-1176-L
Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
Hewitson L, 2010, ACTA NEUROBIOL EXP, V70, P147
Hornig M, 2004, MOL PSYCHIATR, V9, P833, DOI 10.1038/sj.mp.4001529
Hviid A, 2003, JAMA-J AM MED ASSOC, V290, P1763, DOI 10.1001/jama.290.13.1763
Immunization Safety Review Committee, 2004, IMM SAF REV VACC AUT
Iwata K, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-16
Jung NH, 2013, DEV MED CHILD NEUROL, V55, P83, DOI 10.1111/dmcn.12012
Kern JK, 2012, ACTA NEUROBIOL EXP, V72, P113
Kovesdi E, 2007, BRAIN RES, V1147, P272, DOI 10.1016/j.brainres.2007.02.011
Laurente Jonny, 2007, An. Fac. med., V68, P222
Madsen KM, 2003, PEDIATRICS, V112, P604, DOI 10.1542/peds.112.3.604
Majewska MD, 2010, ACTA NEUROBIOL EXP, V70, P196
Massey PV, 2004, J NEUROSCI, V24, P7821, DOI 10.1523/JNEUROSCI.1697-04.2004
McFadden K, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00671
Mutter J, 2005, NEUROENDOCRINOL LETT, V26, P439
Nelson KB, 2003, PEDIATRICS, V111, P674, DOI 10.1542/peds.111.3.674
Nicolson R, 2006, PSYCHIAT RES-NEUROIM, V148, P11, DOI 10.1016/j.pscychresns.2006.02.005
Olczak M, 2011, BEHAV BRAIN RES, V223, P107, DOI 10.1016/j.bbr.2011.04.026
Olczak M, 2010, FOLIA NEUROPATHOL, V48, P258
Olczak M, 2009, BRAIN RES, V1301, P143, DOI 10.1016/j.brainres.2009.09.003
Pless R, 2000, J PEDIATR-US, V136, P571, DOI 10.1067/mpd.2000.106797
Poirier M, 2011, J ABNORM PSYCHOL, V120, P247, DOI 10.1037/a0022298
Preston AR, 2013, CURR BIOL, V23, pR764, DOI 10.1016/j.cub.2013.05.041
Qvarnstrom J, 2003, ANAL CHEM, V75, P4120, DOI 10.1021/ac0342370
Raymond GV, 1996, ACTA NEUROPATHOL, V91, P117
RODIN E, 1984, EPILEPSIA, V25, P690, DOI 10.1111/j.1528-1157.1984.tb03478.x
Rojas DC, 2004, AM J PSYCHIAT, V161, P2038, DOI 10.1176/appi.ajp.161.11.2038
Saitoh O, 2001, BRAIN, V124, P1317, DOI 10.1093/brain/124.7.1317
Salmond CH, 2005, EUR J NEUROSCI, V22, P764, DOI 10.1111/j.1460-9568.2005.04217.x
Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
Stehr-Green P, 2003, AM J PREV MED, V25, P101, DOI 10.1016/S0749-3797(03)00113-2
Strekalova T, 2010, PROG NEURO-PSYCHOPH, V34, P348, DOI 10.1016/j.pnpbp.2009.12.014
Sweeten TL, 2003, PEDIATRICS, V112, pE420, DOI 10.1542/peds.112.5.e420
Sweeten TL, 2002, PHARMACOL BIOCHEM BE, V71, P449, DOI 10.1016/S0091-3057(01)00697-9
Thompson WW, 2007, NEW ENGL J MED, V357, P1281, DOI 10.1056/NEJMoa071434
Torres AR, 2002, HUM IMMUNOL, V63, P311, DOI 10.1016/S0198-8859(02)00374-9
Tripodianakis J, 2007, EUR ARCH PSY CLIN N, V257, P135, DOI 10.1007/s00406-006-0686-y
Verstraeten T, 2003, PEDIATRICS, V112, P1039
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Wallace GL, 2012, J NEUROSCI, V32, P4856, DOI 10.1523/JNEUROSCI.6214-11.2012
Wang FL, 2013, HUM MOL GENET, V22, P3641, DOI 10.1093/hmg/ddt214
Wang LK, 2010, BIOINFORMATICS, V26, P136, DOI 10.1093/bioinformatics/btp612
Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
WHO IRIS, 2002, WEEKLY EPIDEMIOL REC, V77, P305
Yang M, 2011, CURR PROTOC NEUROSCI, DOI DOI 10.1002/0471142301.NS0826S56.:UNIT
Young HA, 2008, J NEUROL SCI, V271, P110, DOI 10.1016/j.jns.2008.04.002
ZHANG J, 1984, AM J IND MED, V5, P251, DOI 10.1002/ajim.4700050308
Zhao WM, 2011, BIOINFORMATICS, V27, P3076, DOI 10.1093/bioinformatics/btr504
NR 78
TC 3
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUN
PY 2014
VL 139
IS 2
BP 452
EP 465
DI 10.1093/toxsci/kfu049
PG 14
WC Toxicology
SC Toxicology
GA AI7MO
UT WOS:000337075900016
PM 24675092
ER
PT J
AU Garg, N
Silverberg, JI
AF Garg, Nitin
Silverberg, Jonathan I.
TI Association between childhood allergic disease, psychological
comorbidity, and injury requiring medical attention
SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
LA English
DT Article
ID DEFICIT HYPERACTIVITY DISORDER; INCREASED RISK; DEFICIT/HYPERACTIVITY
DISORDER; UNINTENTIONAL INJURY; ATOPIC-DERMATITIS; CHILDREN; ASTHMA;
SLEEP; ADOLESCENTS; BEHAVIOR
AB Background: Children with allergic disease have multiple risk factors for accidental injuries.
Objective: To determine the prevalence of injuries requiring medical treatment in US children with allergic disease.
Methods: The authors analyzed data from the 2007 to 2008 National Survey of Children's Health, including a nationally representative sample of 27,556 children 0 to 5 years old.
Results: The prevalence (95% confidence interval [CI]) of at least 1 allergic disease was 29.4% (28.0-30.8); 6.6% (5.8-7.4) were diagnosed with asthma, 15.0% (14.0-16.0) with eczema, 11.6% (10.6-12.6) with hay fever, and 6.1% (5.4-6.9) with food allergy. Children with allergic disorders had higher odds of at least 1 comorbid psychiatric and behavioral disorder (PBD; survey logistic regression; odds ratio 2.93, 95% CI 2.13 -4.03), including attention-deficit/hyperactivity disorder (4.75, 2.89-7.80), depression (6.03, 1.29-28.27), anxiety (5.54, 2.70-11.37), conduct/oppositional defiant disorder (2.97, 1.88-4.70), and learning delay (2.49, 1.70-3.66), but not autism/ Asperger disorder (1.89, 0.98-3.64). The prevalence of injury in the past year requiring medical attention was 10.5% (95% CI 9.5-11.4). The association between allergic disease and injury requiring medical attention was mediated in part by a PBD (Sobel test 0.0021, 95% CI 0.0014-0.0029, P < .0001; bootstrapping approach, indirect effects, odds ratio 1.005, 95% CI 1.003-1.007; Baron-Kenny beta(yx, m) 0.04, P < .0001, R-2 = 0.002). However, children with at least 1 allergic disorder (1.74, 1.23-2.46), including eczema (1.59, 1.01-2.50), asthma (1.91, 1.10-3.31), hay fever (2.05, 1.24-3.39), and food allergies (2.00, 1.10-3.67), had higher odds of sustaining injuries even after controlling for comorbid PBDs and medical disorders.
Conclusion: The results suggest that the association between allergic disease and injury is multifactorial, including being secondary to PBD. (C) 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
C1 [Garg, Nitin; Silverberg, Jonathan I.] Northwestern Univ, Dept Dermatol, Chicago, IL 60611 USA.
[Silverberg, Jonathan I.] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA.
[Silverberg, Jonathan I.] Northwestern Univ, Dept Med Social Sci, Chicago, IL 60611 USA.
RP Garg, N (reprint author), Northwestern Univ, Dept Dermatol, 680 Lakeshore Dr,Suite 1400, Chicago, IL 60611 USA.
EM jonathan.silverberg@northwestern.edu
CR Asher MI, 2006, LANCET, V368, P733, DOI 10.1016/S0140-6736(06)69283-0
Baena-Cagnani C E, 2001, Curr Allergy Asthma Rep, V1, P297, DOI 10.1007/s11882-001-0037-z
Baiardini I, 2006, ALLERGY, V61, P1259, DOI 10.1111/j.1398-9995.2006.01221.x
Braman SS, 2006, CHEST S1, V130, p4S, DOI DOI 10.1378/CHEST.130.1_
Byrne JM, 2003, CHILD NEUROPSYCHOL, V9, P142, DOI 10.1076/chin.9.2.142.14501
Chang HY, 2013, ALLERGY ASTHMA IMMUN, V5, P315, DOI 10.4168/aair.2013.5.5.315
Chen MH, 2013, J CHILD PSYCHOL PSYC, V54, P1208, DOI 10.1111/jcpp.12087
DiScala C, 1998, PEDIATRICS, V102, P1415, DOI 10.1542/peds.102.6.1415
FARMER JE, 1995, HEALTH PSYCHOL, V14, P325, DOI 10.1037/0278-6133.14.4.325
Finkle WD, 2002, ANN ALLERG ASTHMA IM, V89, P244
Goodwin M B, 1993, Aust Clin Rev, V13, P141
Hanrahan LP, 2003, AM J IND MED, V44, P438, DOI 10.1002/ajim.10285
Infante M, 2007, J CLIN PSYCHIAT, V68, P1419
Koulouglioti C, 2008, PUBLIC HEALTH NURS, V25, P106, DOI 10.1111/j.1525-1446.2008.00687.x
Lee LC, 2008, RES DEV DISABIL, V29, P247, DOI 10.1016/j.ridd.2007.05.002
Leynaert Bénédicte, 2003, Curr Opin Allergy Clin Immunol, V3, P177, DOI 10.1097/00130832-200306000-00005
Liang WB, 2011, J ASTHMA, V48, P311, DOI 10.3109/02770903.2011.554945
Liang WB, 2011, J ASTHMA, V48, P736, DOI 10.3109/02770903.2011.599910
National Vital Statistics System, 2011, 10 LEAD CAUS DEATH A
Ozer K, 2010, J PEDIATR ORTHOPED, V30, P324, DOI 10.1097/BPO.0b013e3181d8fa8c
Pinquart M, 2011, J PEDIATR PSYCHOL, V36, P1003, DOI 10.1093/jpepsy/jsr042
Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
Romanos M, 2010, J EPIDEMIOL COMMUN H, V64, P269, DOI 10.1136/jech.2009.093534
Rowe R, 2004, J PEDIATR PSYCHOL, V29, P119, DOI 10.1093/jpepsy/jsh015
Schwebel David C, 2011, Chronic Illn, V7, P201, DOI 10.1177/1742395310394220
Schwebel DC, 2002, J PEDIATR PSYCHOL, V27, P727, DOI 10.1093/jpepsy/27.8.727
Schwebel DC, 2011, ACAD PEDIATR, V11, P427, DOI 10.1016/j.acap.2011.03.003
Schwebel DC, 2009, J ASTHMA, V46, P560, DOI 10.1080/02770900902866750
Shilon Y, 2012, CHILD CARE HLTH DEV, V38, P366, DOI 10.1111/j.1365-2214.2011.01278.x
Slattery MJ, 2011, J ALLERGY CLIN IMMUN, V128, P668, DOI 10.1016/j.jaci.2011.05.003
Slattery MJ, 2011, J PSYCHIATR RES, V45, P788, DOI 10.1016/j.jpsychires.2010.11.003
Slattery MJ, 2005, IMMUNOL ALLERGY CLIN, V25, P407, DOI 10.1016/j.iac.2005.02.007
Tai YM, 2013, RES DEV DISABIL, V34, P1100, DOI 10.1016/j.ridd.2012.11.027
Valent F, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.2.e23
PARRISH H M, 1958, N Y State J Med, V58, P838
WEIL T P, 1958, Hospitals, V32, P43
Xiang HY, 2005, AM J PUBLIC HEALTH, V95, P1970, DOI 10.2105/AJPH.2004.057505
Yaghmaie P, 2013, J ALLERGY CLIN IMMUN, V131, P428, DOI 10.1016/j.jaci.2012.10.041
NR 38
TC 7
Z9 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1081-1206
EI 1534-4436
J9 ANN ALLERG ASTHMA IM
JI Ann. Allergy Asthma Immunol.
PD JUN
PY 2014
VL 112
IS 6
BP 525
EP 532
DI 10.1016/j.anai.2014.03.006
PG 8
WC Allergy; Immunology
SC Allergy; Immunology
GA AH9XJ
UT WOS:000336498400009
PM 24713577
ER
PT J
AU von dem Hagen, EAH
Stoyanova, RS
Rowe, JB
Baron-Cohen, S
Calder, AJ
AF von dem Hagen, Elisabeth A. H.
Stoyanova, Raliza S.
Rowe, James B.
Baron-Cohen, Simon
Calder, Andrew J.
TI Direct Gaze Elicits Atypical Activation of the Theory-of-Mind Network in
Autism Spectrum Conditions
SO CEREBRAL CORTEX
LA English
DT Article
DE autism; connectivity; eye gaze; theory-of-mind
ID EYE-GAZE; BRAIN MECHANISMS; SOCIAL-INTERACTION; AVERTED GAZE; NEURAL
BASIS; HEAD MOTION; CHILDREN; INDIVIDUALS; EMOTION; OTHERS
AB Eye contact plays a key role in social interaction and is frequently reported to be atypical in individuals with autism spectrum conditions (ASCs). Despite the importance of direct gaze, previous functional magnetic resonance imaging in ASC has generally focused on paradigms using averted gaze. The current study sought to determine the neural processing of faces displaying direct and averted gaze in 18 males with ASC and 23 matched controls. Controls showed an increased response to direct gaze in brain areas implicated in theory-of-mind and gaze perception, including medial prefrontal cortex, temporoparietal junction, posterior superior temporal sulcus region, and amygdala. In contrast, the same regions showed an increased response to averted gaze in individuals with an ASC. This difference was confirmed by a significant gaze direction x group interaction. Relative to controls, participants with ASC also showed reduced functional connectivity between these regions. We suggest that, in the typical brain, perceiving another person gazing directly at you triggers spontaneous attributions of mental states (e.g. he is "interested" in me), and that such mental state attributions to direct gaze may be reduced or absent in the autistic brain.
C1 [von dem Hagen, Elisabeth A. H.; Stoyanova, Raliza S.; Rowe, James B.; Calder, Andrew J.] MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England.
[Rowe, James B.] Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 2QQ, England.
[Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England.
RP von dem Hagen, EAH (reprint author), MRC, Cognit & Brain Sci Unit, 15 Chaucer Rd, Cambridge CB2 7EF, England.
EM elisabeth.vondemhagen@mrc-cbu.cam.ac.uk
FU UK Medical Research Council [MC_US_A060_5PQ50]; Wellcome Trust [088324];
UK Medical Research Council
FX This work was funded by the UK Medical Research Council
(MC_US_A060_5PQ50 to A.J.C. and a program grant to S. B. C.). J.B.R. is
supported by the Wellcome Trust (088324). Funding to pay the Open Access
publication charges for this article was provided by the UK Medical
Research Council.
CR Adams RB, 2003, PSYCHOL SCI, V14, P644, DOI 10.1046/j.0956-7976.2003.psci_1479.x
Adams RB, 2005, EMOTION, V5, P3, DOI 10.1037/1528-3542.5.1.3
Akechi H, 2009, CHILD DEV, V80, P1134, DOI 10.1111/j.1467-8624.2009.01321.x
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
BaronCohen S, 1997, CHILD DEV, V68, P48
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
BARONCOHEN S, 1994, CAH PSYCHOL COGN, V13, P513
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Calder AJ, 2002, NEUROPSYCHOLOGIA, V40, P1129, DOI 10.1016/S0028-3932(02)00008-8
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Csibra G, 2006, ATTENTION PERFORM, P249
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
Elsabbagh M, 2012, CURR BIOL, V22, P338, DOI 10.1016/j.cub.2011.12.056
Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
Fox E, 2007, EMOTION, V7, P478, DOI 10.1037/1528-3542.7.3.478
Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
Frith CD, 2006, NEURON, V50, P531, DOI 10.1016/j.neuron.2006.05.001
Greene DJ, 2011, NEUROIMAGE, V56, P354, DOI 10.1016/j.neuroimage.2011.02.031
Grezes J, 2004, J NEUROSCI, V24, P5500, DOI 10.1523/JNEUROSCI.0219-04.2004
Grice SJ, 2005, CORTEX, V41, P342, DOI 10.1016/S0010-9452(08)70271-5
Kampe KKW, 2003, J NEUROSCI, V23, P5258
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kuzmanovic B, 2009, NEUROIMAGE, V46, P1154, DOI 10.1016/j.neuroimage.2009.03.037
Lombardo MV, 2010, J COGNITIVE NEUROSCI, V22, P1623, DOI 10.1162/jocn.2009.21287
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Macrae CN, 2002, PSYCHOL SCI, V13, P460, DOI 10.1111/1467-9280.00481
Nummenmaa L, 2009, TRENDS COGN SCI, V13, P135, DOI 10.1016/j.tics.2008.12.006
Pellicano E, 2009, PSYCHON B REV, V16, P1094, DOI 10.3758/PBR.16.6.1094
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404
Pitskel NB, 2011, J AUTISM DEV DISORD, V41, P1686, DOI 10.1007/s10803-011-1197-x
Redcay E, 2010, NEUROIMAGE, V50, P1639, DOI 10.1016/j.neuroimage.2010.01.052
Redcay E, HUM BRAIN MAPP
Satterthwaite TD, 2012, NEUROIMAGE, V60, P623, DOI 10.1016/j.neuroimage.2011.12.063
Schilbach L, 2006, NEUROPSYCHOLOGIA, V44, P718, DOI 10.1016/j.neuropsychologia.2005.07.017
Senju A, 2008, BRAIN COGNITION, V67, P127, DOI 10.1016/j.bandc.2007.12.001
Senju A, 2005, NEUROPSYCHOLOGIA, V43, P1297, DOI 10.1016/j.neuropsychologia.2004.12.002
Senju A, 2003, COGNITION, V89, pB43, DOI 10.1016/S0010-0277(03)00081-7
Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
vonGrunau M, 1995, PERCEPTION, V24, P1297
Vuilleumier P, 2005, VIS COGN, V12, P85, DOI 10.1080/13506280444000120
Walter H, 2004, J COGNITIVE NEUROSCI, V16, P1854, DOI 10.1162/0898929042947838
Wicker B, 2003, NEUROPSYCHOLOGIA, V41, P139, DOI 10.1016/S0028-3932(02)00144-6
Williams JHG, 2005, NEUROIMAGE, V25, P133, DOI 10.1016/j.neuroimage.2004.10.047
NR 48
TC 7
Z9 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD JUN
PY 2014
VL 24
IS 6
BP 1485
EP 1492
DI 10.1093/cercor/bht003
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA AI0IG
UT WOS:000336529700007
PM 23324559
ER
PT J
AU Piton, A
Poquet, H
Redin, C
Masurel, A
Lauer, J
Muller, J
Thevenon, J
Herenger, Y
Chancenotte, S
Bonnet, M
Pinoit, JM
Huet, F
Thauvin-Robinet, C
Jaeger, AS
Le Gras, S
Jost, B
Gerard, B
Peoc'h, K
Launay, JM
Faivre, L
Mandel, JL
AF Piton, Amelie
Poquet, Helene
Redin, Claire
Masurel, Alice
Lauer, Julia
Muller, Jean
Thevenon, Julien
Herenger, Yvan
Chancenotte, Sophie
Bonnet, Marlene
Pinoit, Jean-Michel
Huet, Frederic
Thauvin-Robinet, Christel
Jaeger, Anne-Sophie
Le Gras, Stephanie
Jost, Bernard
Gerard, Benedicte
Peoc'h, Katell
Launay, Jean-Marie
Faivre, Laurence
Mandel, Jean-Louis
TI 20 ans apres: a second mutation in MAOA identified by targeted
high-throughput sequencing in a family with altered behavior and
cognition
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE monoamine oxidase A; X-linked intellectual deficiency; behavioral
abnormalities; autism; high-throughput sequencing
ID MONOAMINE-OXIDASE-A; FUNCTIONAL POLYMORPHISM; MENTAL-RETARDATION;
SPLICING SIGNALS; GENE; MICE; SITE; SEROTONIN; PROMOTER; CATECHOLAMINES
AB Intellectual disability (ID) is characterized by an extraordinary genetic heterogeneity, with 4250 genes that have been implicated in monogenic forms of ID. Because this complexity precluded systematic testing for mutations and because clinical features are often non-specific, for some of these genes only few cases or families have been unambiguously documented. It is the case of the X-linked gene encoding monoamine oxidase A (MAOA), for which only one nonsense mutation has been identified in Brunner syndrome, characterized in a single family by mild non-dysmorphic ID and impulsive, violent and aggressive behaviors. We have performed targeted high-throughput sequencing of 220 genes, including MAOA, in patients with undiagnosed ID. We identified ac. 797_798delinsTT (p.C266F) missense mutation in MAOA in a boy with autism spectrum disorder, attention deficit and autoaggressive behavior. Two maternal uncles carry the mutation and have severe ID, with a history of maltreatment in early childhood. This novel missense mutation decreases MAOA enzymatic activity, leading to abnormal levels of urinary monoamines. The identification of this new point mutation confirms, for the first time since 1993, the monogenic implication of the MAOA gene in ID of various degrees, autism and behavioral disturbances. The variable expressivity of the mutation observed in male patients of this family may involve gene-environment interactions, and the identification of a perturbation in monoamine metabolism should be taken into account when prescribing psychoactive drugs in such patients.
C1 [Piton, Amelie; Redin, Claire; Muller, Jean; Mandel, Jean-Louis] Univ Strasbourg, CNRS, UMR 7104, IGBMC,INSERM,U964, Illkirch Graffenstaden, France.
[Piton, Amelie; Redin, Claire; Mandel, Jean-Louis] Coll France, Chaire Genet Humaine, F-75231 Paris, France.
[Poquet, Helene; Masurel, Alice; Thevenon, Julien; Chancenotte, Sophie; Huet, Frederic; Thauvin-Robinet, Christel; Faivre, Laurence] Hop Enfants, Ctr Genet, Dijon, France.
[Poquet, Helene; Masurel, Alice; Thevenon, Julien; Chancenotte, Sophie; Huet, Frederic; Thauvin-Robinet, Christel; Faivre, Laurence] Hop Enfants, Ctr Reference Anomalies Dev & Syndromes Malformat, Dijon, France.
[Poquet, Helene; Pinoit, Jean-Michel] Hop Enfants, Serv Pedopsychiat, Dijon, France.
[Lauer, Julia; Muller, Jean; Herenger, Yvan; Jaeger, Anne-Sophie; Gerard, Benedicte; Mandel, Jean-Louis] Hop Univ Strasbourg, Lab Diagnost Genet, Strasbourg, France.
[Thevenon, Julien; Thauvin-Robinet, Christel; Faivre, Laurence] Univ Bourgogne, Fac Med, EA GAD 4271, Dijon, France.
[Chancenotte, Sophie; Bonnet, Marlene] Hop Enfants, Ctr Referent Troubles Langage & Apprentissages, Dijon, France.
[Le Gras, Stephanie; Jost, Bernard] IGBMC, Illkirch Graffenstaden, France.
[Peoc'h, Katell; Launay, Jean-Marie] Grp Hosp Univ St Louis Lariboisiere Fernand Widal, AP HP, Serv Biochim & Biol Mol, Paris, France.
RP Piton, A (reprint author), Univ Strasbourg, CNRS, UMR 7104, Dept Translat Med & Neurogenet,IGBMC,INSERM,U964, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France.
EM piton@igbmc.fr; jlmandel@igbmc.fr
FU Agence de BioMedecine; Fondation Jerome Lejeune; Fondation pour la
Recherche Medicale; Fondation APLM; 7th European Union Framework
[241995]
FX We thank Nadege Calmels, Nadine Kempf, Valerie Biancalana and all the
other members of the Genetic Diagnostic Laboratory of Nouvel Hopital
Civil (Strasbourg) for their help with patient DNA samples selection and
preparation. We thank Serge Vicaire and Muriel Phillips for their help
and technical assistance with HTS. We would also like to thank Veronique
Geoffroy and Cecile Pizot for the development of VaRank. We are very
grateful to Pr Han Brunner for providing us DNA for one member of the
initial Brunner-syndrome family. This work was supported by Agence de
BioMedecine, Fondation Jerome Lejeune, Fondation pour la Recherche
Medicale and Fondation APLM. This project also benefitiated from 7th
European Union Framework (grant no. 241995; GENCODYS).
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
ALLEN RC, 1992, AM J HUM GENET, V51, P1229
Bortolato M, 2013, INT J NEUROPSYCHOPH, V16, P869, DOI 10.1017/S1461145712000715
BRUNNER HG, 1993, SCIENCE, V262, P578, DOI 10.1126/science.8211186
BRUNNER HG, 1993, AM J HUM GENET, V52, P1032
CASES O, 1995, SCIENCE, V268, P1763, DOI 10.1126/science.7792602
Caspi A, 2002, SCIENCE, V297, P851, DOI 10.1126/science.1072290
CELADA P, 1993, J NEUROCHEM, V61, P2191, DOI 10.1111/j.1471-4159.1993.tb07459.x
CESURA AM, 1990, MOL PHARMACOL, V37, P358
Cohen IL, 2003, CLIN GENET, V64, P190, DOI 10.1034/j.1399-0004.2003.00115.x
COLLINS FA, 1992, AM J MED GENET, V42, P127, DOI 10.1002/ajmg.1320420126
DENNEY RM, 1982, SCIENCE, V215, P1400, DOI 10.1126/science.7063850
Desmet FO, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkp215
EISENHOFER G, 1994, J PHARMACOL EXP THER, V268, P1242
Fergusson DM, 2011, BRIT J PSYCHIAT, V198, P457, DOI 10.1192/bjp.bp.110.086991
Fox MA, 2013, PHARMACOGENOMICS J, V13, P551, DOI 10.1038/tpj.2012.35
Haavik J, 2008, HUM MUTAT, V29, P891, DOI 10.1002/humu.20700
Jou RJ, 2005, J CHILD ADOL PSYCHOP, V15, P325, DOI 10.1089/cap.2005.15.325
KEMA IP, 1994, CLIN CHEM, V40, P86
Kim-Cohen J, 2006, MOL PSYCHIATR, V11, P903, DOI 10.1038/sj.mp.4001851
Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
Lubs HA, 2012, AM J HUM GENET, V90, P579, DOI 10.1016/j.ajhg.2012.02.018
Lung FW, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-74
Luu TD, 2012, NUCLEIC ACIDS RES, V40, pW71, DOI 10.1093/nar/gks474
May ME, 2009, AJIDD-AM J INTELLECT, V114, P269, DOI 10.1352/1944-7558-114.4.269-273
Ng PC, 2003, NUCLEIC ACIDS RES, V31, P3812, DOI 10.1093/nar/gkg509
O'Leary RE, 2012, EUR J MED GENET, V55, P349, DOI 10.1016/j.ejmg.2012.01.007
Pertea M, 2001, NUCLEIC ACIDS RES, V29, P1185, DOI 10.1093/nar/29.5.1185
Piton A, 2011, Mol Psychiatry, V16, P867, DOI 10.1038/mp.2010.54
Piton A, 2013, AM J HUMAN GENET, VS0002-9297, P00282
Pussard E, 2009, CLIN BIOCHEM, V42, P536, DOI 10.1016/j.clinbiochem.2008.10.022
Redin C, 2012, J MED GENET, V49, P502, DOI 10.1136/jmedgenet-2012-100875
Reese MG, 1997, J COMPUT BIOL, V4, P311, DOI 10.1089/cmb.1997.4.311
Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
Sabol SZ, 1998, HUM GENET, V103, P273, DOI 10.1007/s004390050816
Saito M, 2013, BRAIN DEV, VS0387-7604, P00020
Schuback DE, 1999, AM J MED GENET, V88, P25
Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
Scott AL, 2008, NEUROREPORT, V19, P739, DOI 10.1097/WNR.0b013e3282fd6e88
Son SY, 2008, P NATL ACAD SCI USA, V105, P5739, DOI 10.1073/pnas.0710626105
SPARROW SS, 1985, J PEDIATR PSYCHOL, V10, P215, DOI 10.1093/jpepsy/10.2.215
Tarpey PS, 2009, NAT GENET, V41, P535, DOI 10.1038/ng.367
Whibley A, EUR J HUM GENET, V18, P1095
WU HF, 1993, MOL PHARMACOL, V43, P888
Yeo G, 2004, J COMPUT BIOL, V11, P377, DOI 10.1089/1066527041410418
NR 46
TC 5
Z9 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD JUN
PY 2014
VL 22
IS 6
BP 776
EP 783
DI 10.1038/ejhg.2013.243
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AH9WW
UT WOS:000336496800010
PM 24169519
ER
PT J
AU Lugo, JN
Swann, JW
Anderson, AE
AF Lugo, Joaquin N.
Swann, John W.
Anderson, Anne E.
TI Early-life seizures result in deficits in social behavior and learning
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Autism; Epilepsy; Recurrent seizures; Flurothyl; Social behavior;
Learning; Memory; Repetitive behavior; Autistic; Comorbidity;
Co-morbidity
ID AUTISM SPECTRUM DISORDERS; MEDIAL PREFRONTAL CORTEX; GLUTAMATERGIC
SYNAPSES; RECURRENT SEIZURES; NEONATAL SEIZURES; NMDA RECEPTORS; MOUSE
MODEL; HIPPOCAMPAL; ANXIETY; CHILDREN
AB Children with epilepsy show a high co-morbidity with psychiatric disorders and autism. One of the critical determinants of a child's behavioral outcome with autism and cognitive dysfunction is the age of onset of seizures. In order to examine whether seizures during postnatal days 7-11 result in learning and memory deficits and behavioral features of autism we administered the inhalant flurothyl to induce seizures in C57BL/6J mice. Mice received three seizures per day for five days starting on postnatal day 7. Parallel control groups consisted of similarly handled animals that were not exposed to flurothyl and naive mice. Subjects were then processed through a battery of behavioral tests in adulthood: elevated-plus maze, nose-poke assay, marble burying, social partition, social chamber, fear conditioning, and Morris water maze. Mice with early-life seizures had learning and memory deficits in the training portion of the Morris water maze (p < 0.05) and probe trial (p < 0.01). Mice with seizures showed no differences in marble burying, the nose-poke assay, or elevated plus-maze testing compared to controls. However, they showed a significant difference in the social chamber and social partition tests. Mice with seizures during postnatal days 7-11 showed a significant decrease in social interaction in the social chamber test and had a significant impairment in social behavior in the social partition test. Together, these results indicate that early life seizures result in deficits in hippocampal-dependent memory tasks and produce long-term disruptions in social behavior. (C) 2014 Elsevier Inc All rights reserved.
C1 [Lugo, Joaquin N.] Baylor Univ, Dept Psychol & Neurosci, Waco, TX 76798 USA.
[Lugo, Joaquin N.; Swann, John W.; Anderson, Anne E.] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Cain Fdn Labs, Houston, TX 77030 USA.
[Lugo, Joaquin N.; Swann, John W.; Anderson, Anne E.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Swann, John W.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA.
[Anderson, Anne E.] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
RP Lugo, JN (reprint author), Baylor Univ, Dept Psychol & Neurosci, One Bear Pl 97334, Waco, TX 76706 USA.
EM joaquin_lugo@baylor.edu
FU Epilepsy Foundation [221523]; NIH from the Eunice Kennedy Shriver
Institute of Child Health and Human Development [NS056664, P30HD
024064]; NIH NINDS [NS049427, NS039943, NS018309]
FX This research was funded by the Epilepsy Foundation (221523) and NIH
NS056664 Postdoctoral Fellowships to JNL, NIH NINDS grants NS049427 and
NS039943 to AEA, and NIH NINDS grant NS018309 to JWS. The work was
completed at the Baylor College of Medicine Intellectual and
Developmental Disabilities Research Center (IDDRC) Mouse Neurobehavior
Core, which receives funding from the NIH P30HD 024064 from the Eunice
Kennedy Shriver Institute of Child Health and Human Development. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the Eunice Kennedy Shriver
National Institute of Child Health & Human Development or the NIH.
CR Bernard PB, 2013, NEUROBIOL DIS, V59, P1, DOI 10.1016/j.nbd.2013.06.013
Bishop SL, 2011, AUTISM RES, V4, P317, DOI 10.1002/aur.216
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
Brodkin ES, 2007, BEHAV BRAIN RES, V176, P53, DOI 10.1016/j.bbr.2006.06.025
Canitano R, 2007, EUR CHILD ADOLES PSY, V16, P61, DOI 10.1007/s00787-006-0563-2
Castelhano ASS, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00036
Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
Cornejo BJ, 2007, ANN NEUROL, V61, P411, DOI 10.1002/ana.21071
Cornejo BJ, 2008, EPILEPSY BEHAV, V13, P585, DOI 10.1016/j.yebeh.2008.07.002
CREAK M, 1969, DEV MED CHILD NEUROL, V11, P218
FILE SE, 1978, BRIT J PHARMACOL, V62, P19
Gilmartin MR, 2010, LEARN MEMORY, V17, P289, DOI 10.1101/lm.1597410
Gilmartin MR, 2013, LEARN MEMORY, V20, P290, DOI 10.1101/lm.030510.113
Hernan AE, 2013, NEUROBIOL DIS, V50, P120, DOI 10.1016/j.nbd.2012.10.007
Holmes GL, 1998, ANN NEUROL, V44, P845, DOI 10.1002/ana.410440602
Karnam HB, 2009, EXP NEUROL, V217, P378, DOI 10.1016/j.expneurol.2009.03.028
Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
Kleen JK, 2011, EPILEPSY BEHAV, V22, P214, DOI 10.1016/j.yebeh.2011.07.022
Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023
Mcllwain KL, 2001, PHYSIOL BEHAV, V73, P705
Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029
Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
Nakazawa K, 2002, SCIENCE, V297, P211, DOI 10.1126/science.1071795
Neill JC, 1996, DEV BRAIN RES, V95, P283, DOI 10.1016/S0165-3806(96)00099-5
Nishimura M, 2011, NEUROBIOL DIS, V44, P205, DOI 10.1016/j.nbd.2011.07.002
Ozsivadjian Ann, 2011, Clin Child Psychol Psychiatry, V16, P203, DOI 10.1177/1359104511404749
Paylor R, 2006, PHYSIOL BEHAV, V87, P95, DOI 10.1016/j.physbeh.2005.09.002
Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x
Saemundsen E, 2007, EPILEPSIA, V48, P1724, DOI 10.1111/j.1528-1167.2007.01150.x
Sayin U, 2004, EPILEPSIA, V45, P1539, DOI 10.1111/j.0013-9580.2004.54903.x
SCHAIN RJ, 1960, J PEDIATR-US, V57, P560, DOI 10.1016/S0022-3476(60)80084-4
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.00123.x
Swann JW, 2007, DEV NEUROSCI-BASEL, V29, P168, DOI 10.1159/000096221
Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
Tsien JZ, 1996, CELL, V87, P1327, DOI 10.1016/S0092-8674(00)81827-9
Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6
Waltereit R., 2010, BEHAV GENET, V41, P364
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
NR 41
TC 4
Z9 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD JUN
PY 2014
VL 256
BP 74
EP 80
DI 10.1016/j.expneurol.2014.03.014
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA AI1VZ
UT WOS:000336644600010
PM 24685665
ER
PT J
AU Kasari, C
Kaiser, A
Goods, K
Nietfeld, J
Mathy, P
Landa, R
Murphy, S
Almirall, D
AF Kasari, Connie
Kaiser, Ann
Goods, Kelly
Nietfeld, Jennifer
Mathy, Pamela
Landa, Rebecca
Murphy, Susan
Almirall, Daniel
TI Communication Interventions for Minimally Verbal Children With Autism: A
Sequential Multiple Assignment Randomized Trial
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism spectrum disorders; minimally verbal; school-aged; communication
intervention; SMART design
ID ADAPTIVE TREATMENT STRATEGY; SPECTRUM DISORDERS; FOLLOW-UP; JOINT
ATTENTION; PRESCHOOLERS; PLAY
AB Objective: This study tested the effect of beginning treatment with a speech-generating device (SGD) in the context of a blended, adaptive treatment design for improving spontaneous, communicative utterances in school-aged, minimally verbal children with autism. Method: A total of 61 minimally verbal children with autism, aged 5 to 8 years, were randomized to a blended developmental/behavioral intervention (JASP+EMT) with or without the augmentation of a SGD for 6 months with a 3-month follow-up. The intervention consisted of 2 stages. In stage 1, all children received 2 sessions per week for 3 months. Stage 2 intervention was adapted (by increased sessions or adding the SGD) based on the child's early response. The primary outcome was the total number of spontaneous communicative utterances; secondary measures were the total number of novel words and total comments from a natural language sample. Results: Primary aim results found improvements in spontaneous communicative utterances, novel words, and comments that all favored the blended behavioral intervention that began by including an SGD (JASP+EMT+SGD) as opposed to spoken words alone (JASP+EMT). Secondary aim results suggest that the adaptive intervention beginning with JASP+EMT+SGD and intensifying JASP+EMT+SGD for children who were slow responders led to better posttreatment outcomes. Conclusion: Minimally verbal school-aged children can make significant and rapid gains in spoken spontaneous language with a novel, blended intervention that focuses on joint engagement and play skills and incorporates an SGD. Future studies should further explore the tailoring design used in this study to better understand children's response to treatment. Clinical trial registration information Developmental and Augmented Intervention for Facilitating Expressive Language (CCNIA); http://clinicaltrials.gov/; NCT01013545.
C1 [Kasari, Connie] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
[Kasari, Connie; Nietfeld, Jennifer] Vanderbilt Univ, Nashville, TN USA.
[Goods, Kelly] First Five Los Angeles, Los Angeles, CA USA.
[Mathy, Pamela] Univ Utah, Speech Language & Hearing Clin, Salt Lake City, UT 84112 USA.
[Landa, Rebecca] Kennedy Krieger Inst, Baltimore, MD USA.
[Murphy, Susan; Almirall, Daniel] Univ Michigan, Ann Arbor, MI 48109 USA.
RP Kasari, C (reprint author), Univ Calif Los Angeles, Semel Inst 68 268, Los Angeles, CA 90024 USA.
EM kasari@gseis.ucla.edu
FU National Institute of Child Health and Human Development (NICHD)
[R01HD073975-02, R01HD073975-03]; National Institute of Mental Health
(NIMH) [R03MH097954-02, RC4MH092722-01]; National Institute on Drug
Abuse [NIDA] [P50DA10075]
FX This study was funded by Autism Speaks #5666, Characterizing Cognition
in Nonverbal Individuals with Autism, oh initiative begun by Ms. Portia
Iverson and Cure Autism Now. Grant support was also provided by the
National Institute of Child Health and Human Development (NICHD)
R01HD073975-02 (C.K., A.K., S.M., D.A.), and R01HD073975-03 (C.K.,
R.L.), R03MH097954-02 (D.A), and RC4MH092722-01 (D.A) from the National
Institute of Mental Health (NIMH), and P50DA10075 (National Institute on
Drug Abuse [NIDA], S.M., D.A.).
CR Almirall D, 2012, STAT MED, V31, P1887, DOI 10.1002/sim.4512
Almirall D, 2012, J CHILD ADOL PSYCHOP, V22, P364, DOI 10.1089/cap.2011.0073
Altman DG, 1998, BRIT MED J, V317, P1309
Anderson DK, 2007, J ABNORM CHILD PSYCH, V37, P1019
Blischak D., 2003, AUGMENTATIVE ALTERNA, V19, P29, DOI DOI 10.1080/0743461032000056478
Carpenter JR, 2007, STAT METHODS MED RES, V16, P259, DOI 10.1177/0962280206075303
Cohen J., 1988, STAT POWER ANAL BEHA, DOI 10.1234/12345678
Collins LM, 2007, AM J PREV MED, V32, pS112, DOI 10.1016/j.amepre.2007.01.022
Collins LM, 2004, PREV SCI, V5, P185, DOI 10.1023/B:PREV.0000037641.26017.00
Goods KS, 2013, J AUTISM DEV DISORD, V43, P1050, DOI 10.1007/s10803-012-1644-3
Gordon K, 2011, J CONSULT CLIN PSYCH, V79, P447, DOI 10.1037/a0024379
Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
Kaale A, 2014, J AM ACAD CHILD PSY, V53, P188, DOI 10.1016/j.jaac.2013.09.019
Kaiser A. P., 2000, J EARLY ED DEV, V4, P423
KAISER AP, 1993, J ASSOC PERS SEVERE, V18, P137
Kaiser AP, 2013, J SPEECH LANG HEAR R, V56, P295, DOI 10.1044/1092-4388(2012/11-0231)
Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Lord C., 1999, AUTISM DIAGNOSTIC OB
Miller J., 2012, SALT SYSTEMATIC ANAL
Murphy SA, 2005, STAT MED, V24, P1455, DOI 10.1002/sim.2022
Nahum-Shani I, 2012, PSYCHOL METHODS, V17, P457, DOI 10.1037/a0029372
Paul R, 2013, J AUTISM DEV DISORD, V43, P418, DOI 10.1007/s10803-012-1583-z
Pickett E, 2009, COGN BEHAV NEUROL, V22, P1, DOI 10.1097/WNN.0b013e318190d185
RUTTER M, 1967, BRIT J PSYCHIAT, V113, P1183, DOI 10.1192/bjp.113.504.1183
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
Tager-Flusberg H, 2013, AUTISM RES, V6, P468, DOI 10.1002/aur.1329
Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
van der Meer LAJ, 2010, DEV NEUROREHABIL, V13, P294, DOI 10.3109/17518421003671494
Wodka E., 2013, PEDIATRICS, V131, P1
Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
NR 32
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD JUN
PY 2014
VL 53
IS 6
BP 635
EP 646
DI 10.1016/j.jaac.2014.01.019
PG 12
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AI0SO
UT WOS:000336560400007
PM 24839882
ER
PT J
AU Bent, S
Hendren, RL
Zandi, T
Law, K
Choi, JE
Widjaja, F
Kalb, L
Nestle, J
Law, P
AF Bent, Stephen
Hendren, Robert L.
Zandi, Tara
Law, Kiely
Choi, Jae-Eun
Widjaja, Felicia
Kalb, Luther
Nestle, Jay
Law, Paul
TI Internet-Based, Randomized, Controlled Trial of Omega-3 Fatty Acids for
Hyperactivity in Autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism; nutritional supplement; alternative medicine; hyperactivity
ID PERVASIVE DEVELOPMENTAL DISORDERS; PLACEBO-CONTROLLED-TRIAL; SPECTRUM
DISORDERS; PARENT REPORT; CHILDREN; METHYLPHENIDATE; SUPPLEMENTATION;
IRRITABILITY; ARIPIPRAZOLE; RISPERIDONE
AB Objective: Preliminary evidence suggests that omega-3 fatty acids may reduce hyperactivity in children with autism spectrum disorder (ASD). We sought to examine the feasibility of a novel, Internet-based clinical trial design to evaluate the efficacy of this supplement. Method: E-mail invitations were sent to parents of children aged 5 to 8 years enrolled in the Interactive Autism Network. All study procedures, including screening, informed consent, and collection of outcome measures took place over the Internet. The primary Outcome measures were parent- and teacher-rated changes in hyperactivity on the Aberrant Behavior Checklist (ABC-H). Results: During the 6-week recruitment period, 57 children from 28 states satisfied all eligibility criteria and were randomly assigned to 1.3 grams of omega-3 fatty acids or an identical placebo daily for 6 weeks. Outcome assessments were obtained from all 57 participants and 57 teachers, and the study was completed in 3 months. Children in the omega-3 fatty acid group had a greater reduction in hyperactivity (-5.3 points) compared to the placebo group (-2.6 points), but the difference was not statistically significant (1.9-point greater improvement in the omega-3 group, 95% CI = -2.2 to 5.2). Adverse events were rare and not associated with omega-3 fatty acids. Participant feedback was positive. Conclusion: Internet-based, randomized controlled trials of therapies in children with ASD are feasible and may lead to marked reductions in the time and cost of completing trials. A larger sample size is required to definitively determine the efficacy of omega-3 fatty acids. Clinical trial registration information-Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder; http://clinicaltrials.gov; NCT 01694667.
C1 [Bent, Stephen; Hendren, Robert L.; Choi, Jae-Eun; Widjaja, Felicia] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Zandi, Tara; Law, Kiely; Kalb, Luther; Nestle, Jay; Law, Paul] Kennedy Krieger Inst, Baltimore, MD USA.
RP Bent, S (reprint author), San Francisco VA Med Ctr, 111-A1,4150 Clement St, San Francisco, CA 94121 USA.
EM Stephen.Bent@ucsf.edu
FU Simons Foundation [SFARI 206484]; National Center for Research
Resources; National Center for Advancing Translational Sciences,
National Institutes of Health, through UCSF-CTSI [UL1 RR024131]
FX This work was supported by a grant from the Simons Foundation (SFARI
206484, S.B.) and by the National Center for Research Resources and the
National Center for Advancing Translational Sciences, National
Institutes of Health, through UCSF-CTSI Grant Number UL1 RR024131.
CR Aman MG, 2003, J CHILD ADOL PSYCHOP, V13, P29, DOI 10.1089/104454603321666171
Amminger GP, 2007, BIOL PSYCHIAT, V61, P551, DOI 10.1016/j.biopsych.2006.05.007
Amminger GP, 2010, ARCH GEN PSYCHIAT, V67, P146, DOI 10.1001/archgenpsychiatry.2009.192
Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
Bent S, 2011, J AUTISM DEV DISORD, V41, P545, DOI 10.1007/s10803-010-1078-8
Bent S, 2009, J AUTISM DEV DISORD, V39, P1145, DOI 10.1007/s10803-009-0724-5
Bloch MH, 2011, J AM ACAD CHILD PSY, V50, P991, DOI 10.1016/j.jaac.2011.06.008
Freeman MP, 2006, J CLIN PSYCHIAT, V67, P1954
Handen BL, 2000, J AUTISM DEV DISORD, V30, P245, DOI 10.1023/A:1005548619694
Jacobs BP, 2005, MEDICINE, V84, P197, DOI 10.1097/01.md.0000172299.72364.95
King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
Kogan M, 2013, CHANGES PREVALENCE P
Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
Lofthouse N, 2012, AUTISM RES TREAT, V2012, DOI DOI 10.1155/2012/870391
Lord C, 2006, UNDERSTANDING AUTISM
Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
McCulloch C. E., 2000, GEN LINEAR MIXED MOD
Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Research Units on Pediatric Psychopharmacology (RUPP) Autistic Disorder Network, 2005, ARCH GEN PSYCHIAT, V62, P1266
Richardson AJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043909
Rothman K J, 1990, Epidemiology, V1, P43, DOI 10.1097/00001648-199001000-00010
Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
Warren Z, 2012, AUTISM RES, V5, P31, DOI 10.1002/aur.230
Wong AD, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-40
NR 25
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD JUN
PY 2014
VL 53
IS 6
BP 658
EP 666
DI 10.1016/j.jaac.2014.01.018
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AI0SO
UT WOS:000336560400009
PM 24839884
ER
PT J
AU Field, SS
AF Field, Scott S.
TI Interaction of genes and nutritional factors in the etiology of autism
and attention deficit/hyperactivity disorders: A case control study
SO MEDICAL HYPOTHESES
LA English
DT Article
ID DEFICIT HYPERACTIVITY DISORDER; ESSENTIAL FATTY-ACIDS;
PLACEBO-CONTROLLED TRIAL; SPECTRUM DISORDERS; DOCOSAHEXAENOIC ACID;
DOUBLE-BLIND; RISK-FACTORS; YOUNG-CHILDREN; BIRTH-WEIGHT; PATERNAL AGE
AB Objective: To compare risk factors of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) to age/sex-matched controls with particular attention to family history, parental age and nutrition.
Method: 31 ASD and 81 ADHD patients were compared to 612 age/sex-matched controls by reviewing charts for parental age, sibling order, gestational age, and early feeding, and by parental interview for early feeding and family history of psychopathology on affected patients and 139 of those controls.
Findings: Parental age affected ASD and ADHD females but not males. First-born males were at increased risk for both disorders even though their siblings had older parents and their parents were not more likely to stop having children. Breastfeeding in the absence of parental psychopathology reduced ADHD risk, but breastfeeding of first-born males by older mothers with psychopathology was a risk for ASD. Breastfeeding was only a risk for ADHD if the mother had psychopathology. Parent emigration from a place of high fish consumption was a significant ASD risk factor.
Resulting hypotheses: ADHD and ASD share risk factors due to shared genetic and nutritional interactions, likely revolving around deficiencies of omega-3 fatty acids (n3FAs) during brain development. Fatty acid metabolism genes are important in that process. The 4:1 male to female ratio for both disorders results from hormonally driven fat metabolism differences. Risk factors for both disorders including maternal smoking, prematurity, and gestational diabetes may also be attributed to their effect on n3FA supplies. Breastfeeding can be a risk factor when the mother's genes and/or age affect her milk quality. Parental age and gene defects may affect female more than male offspring. Childbirth with adequate spacing and breastfeeding can override maternal age and protect subsequent offspring. Genetic variations in fat metabolism can be influenced by cultural/geographic diet, causing deficiencies in offspring with migration-influenced diet changes. Interaction of n3FA deficient diets, delayed child-bearing, and breastfeeding by mothers with psychopathology may be important factors in the rising incidence of ASD and ADHD in recent decades. Partial prevention through diet and supplements may be possible. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Field, Scott S.] Univ Alabama Birmingham, Huntsville Hosp, Birmingham, AL USA.
RP Field, SS (reprint author), Field Pediat PC, 1106 Gleneagles Dr, Huntsville, AL 35801 USA.
EM scottfieldmd@gmail.com
CR Agostani C., 2010, EARLY HUM DEV, V86, P53
AL MDM, 1995, BRIT J NUTR, V74, P55, DOI 10.1079/BJN19950106
American Psychiatric Association, 2000, TASK FORC DSM 4 DIAG
Amminger GP, 2007, BIOL PSYCHIAT, V61, P551, DOI 10.1016/j.biopsych.2006.05.007
Arterburn LM, 2006, AM J CLIN NUTR, V83, p1467S
Arvindakshan M, 2003, SCHIZOPHR RES, V62, P195, DOI 10.1016/S0920-9964(02)00284-0
Beblo S, 2007, J PEDIATR-US, V150, P479, DOI 10.1016/j.jpeds.2006.12.011
Bell JG, 2004, PROSTAG LEUKOTR ESS, V71, P201, DOI 10.1016/j.plefa.2004.03.008
Bonham MP, 2008, PROSTAG LEUKOTR ESS, V78, P343, DOI 10.1016/j.plefa.2008.04.005
Brookes KJ, 2006, BIOL PSYCHIAT, V60, P1053, DOI 10.1016/j.biopsych.2006.04.025
Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
Cheslack-Postava K, 2011, PEDIATRICS, V127, P246, DOI 10.1542/peds.2010-2371
Childs CE, 2008, P NUTR SOC, V67, P19, DOI 10.1017/S0029665108005983
COLQUHOUN I, 1981, MED HYPOTHESES, V7, P673, DOI 10.1016/0306-9877(81)90014-1
Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250
Emond A, 2010, PEDIATRICS, V126, pE337, DOI 10.1542/peds.2009-2391
Faraone SV, 2010, PSYCHIAT CLIN N AM, V33, P159, DOI 10.1016/j.psc.2009.12.004
Farzaneh-Far R, 2010, JAMA-J AM MED ASSOC, V303, P250, DOI 10.1001/jama.2009.2008
Field SS, 2008, PEDIATRICS, V122, P1416, DOI 10.1542/peds.2008-1645
Fombonne E, 2006, 5 INT M AUT RES 2006
Gabis L, 2010, PEDIATR NEUROL, V43, P300, DOI 10.1016/j.pediatrneurol.2010.05.022
Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
Heird WC, 2007, J PEDIATR-US, V150, P457, DOI 10.1016/j.jpeds.2007.01.030
Helland I. B., 2003, PEDIATRICS, V111, P39
Hendriksen JGM, 2008, J CHILD NEUROL, V23, P477, DOI 10.1177/0883073807309775
Hertz-Picciotto I, 2010, ENVIRON HEALTH PERSP, V118, P161, DOI 10.1289/ehp.0900736
Hirayama S, 2004, EUR J CLIN NUTR, V58, P467, DOI 10.1038/sj.ejcn.1601830
Horrobin DF, 1999, PROSTAG LEUKOTR ESS, V60, P141, DOI 10.1054/plef.1999.0027
Huang T, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-6
Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
Johnson M, 2009, J ATTEN DISORD, V12, P394, DOI 10.1177/1087054708316261
Karmel BZ, 2010, PEDIATRICS, V126, P457, DOI 10.1542/peds.2009-2680
Keen DV, 2010, BRIT J PSYCHIAT, V196, P274, DOI 10.1192/bjp.bp.109.065490
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Larque E, 2011, AM J CLIN NUTR, V94, p1908S, DOI 10.3945/ajcn.110.001230
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Lehn H, 2007, J AM ACAD CHILD PSY, V46, P83, DOI 10.1097/01.chi.0000242244.00174.d9
Lyall K, 2012, AUTISM RES, V5, P21, DOI 10.1002/aur.228
Makrides M, 2010, JAMA-J AM MED ASSOC, V304, P1675, DOI 10.1001/jama.2010.1507
Manning SE, 2011, PEDIATRICS, V127, P1043, DOI 10.1542/peds.2010-2943
Meguid NA, 2008, CLIN BIOCHEM, V41, P1044, DOI 10.1016/j.clinbiochem.2008.05.013
Meiri G, 2009, J CHILD ADOL PSYCHOP, V19, P449, DOI 10.1089/cap.2008.0123
MITCHELL EA, 1987, CLIN PEDIATR, V26, P406, DOI 10.1177/000992288702600805
Molto-Puigmarti C, 2010, AM J CLIN NUTR, V91, P1368, DOI 10.3945/ajcn.2009.28789
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
Ozias MK, 2007, J NUTR, V137, P125
Pasca SP, 2009, J CELL MOL MED, V13, P4229, DOI 10.1111/j.1582-4934.2008.00463.x
Richardson AJ, 2002, PROG NEURO-PSYCHOPH, V26, P233, DOI 10.1016/S0278-5846(01)00254-8
Richardson AJ, 2006, INT REV PSYCHIATR, V18, P155, DOI 10.1080/09540260600583031
Richardson AJ, 2005, PEDIATRICS, V115, P1360, DOI 10.1542/peds.2004-2164
RITVO ER, 1985, AM J PSYCHIAT, V142, P74
Rizwan S, 2007, EARLY HUM DEV, V83, P87, DOI 10.1016/j.earlhumdev.2006.05.005
Ronald A, 2010, J ABNORM CHILD PSYCH, V38, P185, DOI 10.1007/s10802-009-9366-5
Ross BM, 2003, NUTR NEUROSCI, V6, P277, DOI 10.1080/10284150310001612203
Sabel KG, 2009, LIPIDS HLTH DIS, V10, P20
Sagiv SK, 2012, ARCH PEDIAT ADOLESC, V2012, P1
Sasanfar R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-2
Saugstad Letten F., 2008, Nutrition and Health (Bicester), V19, P307
Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049
Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
Schmitt J, 2012, ARCH PEDIAT ADOL MED, V166, P1074, DOI 10.1001/archpediatrics.2012.1078
Schneider A, 2009, DEV DISABIL RES REV, V15, P333, DOI 10.1002/ddrr.80
Schultz Stephen T, 2006, Int Breastfeed J, V1, P16, DOI 10.1186/1746-4358-1-16
Shamberger RJ, 2011, J AM COLL NUTR, V30, P348
Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
Simopoulos AP, 2010, EXP BIOL MED, V235, P785, DOI 10.1258/ebm.2010.009298
Stevens LJ, 1996, PHYSIOL BEHAV, V59, P915, DOI 10.1016/0031-9384(95)02207-4
STEVENS LJ, 1995, AM J CLIN NUTR, V62, P761
Suren P, 2013, JAMA-J AM MED ASSOC, V309, P570, DOI 10.1001/jama.2012.155925
Tanaka K, 2009, BRAIN DEV-JPN, V31, P288, DOI 10.1016/j.braindev.2008.05.011
Visser SN, 2010, MMWR-MORBID MORTAL W, P1439
Voigt RG, 2001, J PEDIATR-US, V139, P189, DOI 10.1067/mpd.2001.116050
Wiest MM, 2009, PROSTAG LEUKOTR ESS, V80, P221, DOI 10.1016/j.plefa.2009.01.007
Xie L, 2008, J NUTR, V138, P2222, DOI 10.3945/jn.108.096156
NR 74
TC 1
Z9 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUN
PY 2014
VL 82
IS 6
BP 654
EP 661
DI 10.1016/j.mehy.2014.02.021
PG 8
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AI2QX
UT WOS:000336704200004
PM 24685108
ER
PT J
AU Gialloreti, LE
Benvenuto, A
Benassi, F
Curatolo, P
AF Gialloreti, Leonardo Emberti
Benvenuto, Arianna
Benassi, Francesca
Curatolo, Paolo
TI Are caesarean sections, induced labor and oxytocin regulation linked to
Autism Spectrum Disorders?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PERINATAL RISK-FACTORS; DEVELOPING-COUNTRIES; DRAMATIC INCREASE;
SOCIAL-BEHAVIOR; RATES; PREVALENCE; CONSEQUENCES; VASOPRESSIN; HEALTH;
CHINA
AB The etiology of Autism Spectrum Disorders (ASDs) continues to be elusive. While ASDs have been shown to be heritable, several environmental co-factors, such as, e.g. pre- or perinatal adverse events, could play a role in the pathogenesis of the disorder as well.
Prevalence of ASDs appears to have increased in the last three decades, but the causes of this surge are not fully understood. As perinatal adverse events have increased as well, they have been regarded as logical contributors to the risen prevalence of ASDs. Over the last three decades there has been also a considerable increase in the rates of induced labor and caesarean sections (CS). However, even if a causal association between CS and ASDs increase has been suggested, it has not yet been proven.
Nevertheless, we hypothesize here that such an association is actual and that it might help to explain a part of the increase in ASD diagnoses. Our assumption is based on the wider epidemiological picture of ASDs and CS, as well as on the possible biological plausibility of this correlation, by postulating potential epigenetic and neurobiological mechanisms underpinning this relationship.
Today, several observations point toward the existence of epigenetic dysregulation in ASDs and this raises the issue of the role of environmental factors in bringing about epigenetic modifications. Epigenetic dysregulations in some brain neuropeptide systems could play a role in the behavioral dysfunctions of ASDs. Particularly, some evidence suggests a dysregulation of the oxytocinergic system in autistic brains. Perinatal alterations of oxytocin (OT) can also have life-long lasting effects on the development of social behaviors. Within the perinatal period, various processes, like pitocin infusion or CS, can alter the OT balance in the newborn; OT dysregulation could then interact with genetic factors, leading ultimately to the development of ASDs.
Large long-term prospective studies are needed to identify causal pathways for ASDs and examine whether and how (epi-)genetic susceptibility interacts with obstetric risk factors in the development of ASDs. A better understanding of such a potential interplay could become paradigmatic for a wide range of genetic-environmental interactions in ASDs. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Gialloreti, Leonardo Emberti] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy.
[Gialloreti, Leonardo Emberti; Benassi, Francesca] Ctr Commun & Neurorehabil Res CNAPP, Rome, Italy.
[Benvenuto, Arianna; Curatolo, Paolo] Univ Roma Tor Vergata, Dept Neurosci, Pediat Neurol Unit, I-00133 Rome, Italy.
RP Gialloreti, LE (reprint author), Univ Roma Tor Vergata, Dept Biomed & Prevent, Via Montpellier 1, I-00133 Rome, Italy.
EM leonardo.emberti.gialloreti@uniroma2.it
CR Al-Farsi Yahya M, 2012, Nutrition, V28, pe27, DOI 10.1016/j.nut.2012.01.007
Arias E, 2003, PEDIATRICS, V112, P1215, DOI 10.1542/peds.112.6.1215
Bartz JA, 2008, PROG BRAIN RES, V170, P451, DOI 10.1016/S0079-6123(08)00435-4
Belizan JM, 2007, EPIDEMIOLOGY, V18, P485, DOI 10.1097/EDE.0b013e318068646a
Benvenuto A, 2013, BRAIN DEV-JPN, V35, P119, DOI 10.1016/j.braindev.2012.03.015
Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
Betran AP, 2007, PAEDIATR PERINAT EP, V21, P98, DOI 10.1111/j.1365-3016.2007.00786.x
Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
Blumberg S. J., 2013, NATL HLTH STAT REPOR, V65
Bogg L, 2010, SOC SCI MED, V70, P1544, DOI 10.1016/j.socscimed.2010.01.026
Buchanan SL, 2012, AUST NZ J OBSTET GYN, V52, P173, DOI 10.1111/j.1479-828X.2011.01403.x
Burstyn I, 2010, CHRONIC DIS CAN, V30, P125
Bystrova K, 2009, BIRTH-ISS PERINAT C, V36, P97, DOI 10.1111/j.1523-536X.2009.00307.x
Carter CS, 2009, DEV NEUROSCI-BASEL, V31, P332, DOI 10.1159/000216544
Carter CS, 2003, PHYSIOL BEHAV, V79, P383, DOI 10.1016/S0031-9384(03)00151-3
Caughey AB, 2009, EVID REP TECHNOL ASS, P1
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Chaste Pauline, 2012, Dialogues Clin Neurosci, V14, P281
Dawson G, 2013, JAMA PSYCHIAT, V70, P9, DOI 10.1001/jamapsychiatry.2013.488
Dobson R, 2001, BRIT MED J, V323, P951
Dodds L, 2011, J AUTISM DEV DISORD, V41, P891, DOI 10.1007/s10803-010-1114-8
Durkin MS, 2010, AM J PUBLIC HEALTH, V100, P389, DOI 10.2105/AJPH.2009.184101
Ebstein RP, 2009, ANN NY ACAD SCI, V1167, P87, DOI 10.1111/j.1749-6632.2009.04541.x
Feng XL, 2012, B WORLD HEALTH ORGAN, V90, P30, DOI 10.2471/BLT.11.090399
Fernandez IO, 2011, REV PSIQUIATR SALUD, V4, P38, DOI 10.1016/j.rpsm.2010.10.004
Flashner BM, 2013, NEUROMOL MED, V15, P339, DOI 10.1007/s12017-013-8222-5
Freeman RK, 2007, AM J OBSTET GYNECOL, V197, P445, DOI 10.1016/j.ajog.2007.08.025
Gale S, 2003, J AUTISM DEV DISORD, V33, P205, DOI 10.1023/A:1022951829477
Gentile I, 2013, MED HYPOTHESES, V81, P26, DOI 10.1016/j.mehy.2013.04.002
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Green JJ, 2010, NEUROTHERAPEUTICS, V7, P250, DOI 10.1016/j.nurt.2010.05.006
Gregory SG, 2013, JAMA PEDIATR, V167, P959, DOI 10.1001/jamapediatrics.2013.2904
Gregory SG, 2009, BMC MED, V22, P7
Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
Guinchat V, 2012, ACTA OBSTET GYN SCAN, V91, P287, DOI 10.1111/j.1600-0412.2011.01325.x
Hall L, 2013, AUTISM
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Harony H, 2010, NEUROSIGNALS, V18, P82, DOI 10.1159/000321035
Hollander E, 1998, CNS SPECTRUMS, V3, P22
Hu VW, 2013, CHILD DEV, V84, P89, DOI 10.1111/j.1467-8624.2012.01759.x
Huguet G, 2013, ANNU REV GENOM HUM G, V14, P191, DOI 10.1146/annurev-genom-091212-153431
Hunter JW, 2010, DIS MODEL MECH, V3, P366, DOI 10.1242/dmm.003442
Isaksen J, 2013, EUR J PAEDIATR NEURO, V17, P327, DOI 10.1016/j.ejpn.2013.03.003
Jack A, 2012, FRONT HUM NEUROSCI, V10, P6
Jonas W, 2008, ARCH WOMEN MENT HLTH, V11, P335, DOI 10.1007/s00737-008-0027-4
King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
Krumm N, 2014, TRENDS NEUROSCI, V37, P95, DOI 10.1016/j.tins.2013.11.005
Kumsta R, 2013, FRONT NEUROSCI, V23, P7
LaSalle JM, 2013, J HUM GENET, V58, P396, DOI 10.1038/jhg.2013.49
Leone T, 2008, SOC SCI MED, V67, P1236, DOI 10.1016/j.socscimed.2008.06.032
Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048
Lukas M, 2013, BEHAV BRAIN RES, V251, P85, DOI 10.1016/j.bbr.2012.08.011
Ma WJ, 2013, MOL AUTISM, V1, P4
Mamrut S, 2013, PLOS ONE, V8, P2
May-Benson TA, 2009, FRONT INTEGR NEUROSC, V11, P3
Mazzoni A, 2011, BJOG-INT J OBSTET GY, V118, P391, DOI 10.1111/j.1471-0528.2010.02793.x
Miyake K, 2012, ADV EXP MED BIOL, V724, P91, DOI 10.1007/978-1-4614-0653-2_7
Muhle R., 2004, PEDIATRICS, V113, P472
Nissen E, 1996, EARLY HUM DEV, V45, P103, DOI 10.1016/0378-3782(96)01725-2
Osterman Michelle J. K., 2013, NCH DATA BRIEF, V124, P1
Polo-Kantola Päivi, 2014, J Pediatr, V164, P358, DOI 10.1016/j.jpeds.2013.09.044
Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
RITVO ER, 1989, AM J PSYCHIAT, V146, P194
Rossoni E, 2008, PLOS COMPUT BIOL, V4, DOI 10.1371/journal.pcbi.1000123
Russell J A, 2001, Prog Brain Res, V133, P1
Schaefer GB, 2013, GENET MED, V15, P669, DOI 10.1038/gim.2013.32
Schanen NC, 2006, HUM MOL GENET, V15, P138, DOI DOI 10.1093/HMG/DDL213
Schieve LA, 2011, ANN EPIDEMIOL, V21, P930, DOI 10.1016/j.annepidem.2011.08.009
Siniscalco D, 2013, INT J ENV RES PUB HE, V10, P4261, DOI 10.3390/ijerph10094261
Stanton CK, 2005, B WORLD HEALTH ORGAN, V83, P449
Steinman G, 2013, MED HYPOTHESES, V81, P999, DOI 10.1016/j.mehy.2013.09.013
Tanne JH, 2012, BMJ-BRIT MED J, V17, pe2768
Villar J, 2006, LANCET, V367, P1819, DOI 10.1016/S0140-6736(06)68704-7
Vogel JP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065612
Volk HE, 2013, JAMA PSYCHIAT, V70, P71, DOI 10.1001/jamapsychiatry.2013.266
Wahl RUR, 2004, MED HYPOTHESES, V63, P456, DOI 10.1016/j.mehy.2004.03.008
Wolstenholme JT, 2012, ENDOCRINOLOGY, V153, P3828, DOI 10.1210/en.2012-1195
Zachor DA, 2014, EUR J PAEDIATR NEURO, V18, P107, DOI 10.1016/j.ejpn.2013.09.002
Zhang X, 2010, J AUTISM DEV DISORD, V40, P1311, DOI 10.1007/s10803-010-0992-0
NR 79
TC 2
Z9 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUN
PY 2014
VL 82
IS 6
BP 713
EP 718
DI 10.1016/j.mehy.2014.03.011
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AI2QX
UT WOS:000336704200018
PM 24685110
ER
PT J
AU Xu, XJ
Xiong, ZM
Zhang, LS
Liu, YL
Lu, LN
Peng, Y
Guo, H
Zhao, JP
Xia, K
Hu, ZM
AF Xu, Xiaojuan
Xiong, Zhimin
Zhang, Lusi
Liu, Yalan
Lu, Lina
Peng, Yu
Guo, Hui
Zhao, Jingping
Xia, Kun
Hu, Zhengmao
TI Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Autism; Neuroligin; NLGN; Variation
ID MENTAL-RETARDATION; NEUROLIGINS; MUTATION; BINDING; DISORDER
AB Autism is a neurodevelopmental disorder clinically characterized by impairment of social interaction, deficits in verbal communication, as well as stereotypic and repetitive behaviors. Several studies have implicated that abnormal synaptogenesis was involved in the incidence of autism. Neuroligins are postsynaptic cell adhesion molecules and interacted with neurexins to regulate the fine balance between excitation and inhibition of synapses. Recently, mutation analysis, cellular and mice models hinted neuroligin mutations probably affected synapse maturation and function. In this study, four missense variations [p.G426S (NLGN3), p.G84R (NLGN4X), p.Q162 K (NLGN4X) and p.A283T (NLGN4X)] in four different unrelated patients have been identified by PCR and direct sequencing. These four missense variations were absent in the 453 controls and have not been reported in 1000 Genomes Project. Bioinformatic analysis of the four missense variations revealed that p.G84R and p.A283T were "Probably Damaging". The variations may cause abnormal synaptic homeostasis and therefore trigger the patients more predisposed to autism. By case-control analysis, we identified the common SNPs (rs3747333 and rs3747334) in the NLGN4X gene significantly associated with risk for autism [p = 5.09E-005; OR 4.685 (95 % CI 2.073-10.592)]. Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population.
C1 [Xu, Xiaojuan; Xiong, Zhimin; Zhang, Lusi; Liu, Yalan; Lu, Lina; Peng, Yu; Guo, Hui; Zhao, Jingping; Xia, Kun; Hu, Zhengmao] Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China.
[Xu, Xiaojuan] Lanzhon Univ, Hosp 1, Reprod Med Hosp, Lanzhou, Gansu, Peoples R China.
[Xiong, Zhimin; Xia, Kun; Hu, Zhengmao] Cent S Univ, Sch Biol Sci & Technol, Changsha, Hunan, Peoples R China.
[Zhao, Jingping] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China.
RP Xia, K (reprint author), Cent S Univ, Sch Biol Sci & Technol, Changsha, Hunan, Peoples R China.
EM xiakun@sklmg.edu.cn; huzhengmao@sklmg.edu.cn
FU National Basic Research Program 973 of China [2012CB 517902, 2010 CB
529601]; National Natural Science Foundation of China [81330027,
81161120544, 31301023]
FX We thank the patients and their families for agreeing to participate in
this study and special teachers whose participation made this project
possible. We also thank Cong Wang and Haoying Hao for sequencing, Jiada
Li for manuscript revision. We were appreciated for the help and advices
of our colleagues. This study was supported by the National Basic
Research Program 973 of China (Grant No. 2012CB 517902, 2010 CB 529601)
and the National Natural Science Foundation of China (Grant No.
81330027, 81161120544, 31301023).
CR BAILEY A, 1995, PSYCHOL MED, V25, P63
Chih B, 2004, HUM MOL GENET, V13, P1471, DOI 10.1093/hmg/ddh158
Daoud H, 2009, BIOL PSYCHIAT, V66, P906, DOI 10.1016/j.biopsych.2009.05.008
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Ey E, 2011, AUTISM RES, V4, P5, DOI 10.1002/aur.175
Ichtchenko K, 1996, J BIOL CHEM, V271, P2676
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Keller F, 2003, MOL NEUROBIOL, V28, P1, DOI 10.1385/MN:28:1:1
Koehnke J, 2008, P NATL ACAD SCI USA, V105, P1873, DOI 10.1073/pnas.0711701105
Lainhart JE, 2002, AM J MED GENET, V113, P231, DOI 10.1002/ajmg.10615
Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006
Levinson JN, 2007, NEURON, V56, P937, DOI 10.1016/j.neuron.2007.12.003
Li XP, 2010, PSYCHIAT GENET, V20, P113, DOI 10.1097/YPG.0b013e32833a216f
Liu YL, 2012, J PSYCHIATR RES, V46, P630, DOI 10.1016/j.jpsychires.2011.10.015
Nguyen T, 1997, J BIOL CHEM, V272, P26032, DOI 10.1074/jbc.272.41.26032
Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805
Rutter M, 2000, J ABNORM CHILD PSYCH, V28, P3, DOI 10.1023/A:1005113900068
Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
Sutcliffe JS, 2008, SCIENCE, V321, P208, DOI 10.1126/science.1160555
Szatmari P, 1998, J AUTISM DEV DISORD, V28, P351, DOI 10.1023/A:1026096203946
Talebizadeh Z, 2006, J MED GENET, V43, DOI 10.1136/jmg.2005.036897
Thomas NS, 1999, HUM GENET, V104, P43, DOI 10.1007/s004390050908
Tsigelny I, 2000, PROTEIN SCI, V9, P180
Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
Yan J, 2008, PSYCHIAT GENET, V18, P204, DOI 10.1097/YPG.0b013e3282fb7fe6
Yan J, 2005, MOL PSYCHIATR, V10, P329, DOI 10.1038/sj.mp.4001629
Zhang C, 2009, J NEUROSCI, V29, P10843, DOI 10.1523/JNEUROSCI.1248-09.2009
NR 28
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD JUN
PY 2014
VL 41
IS 6
BP 4133
EP 4140
DI 10.1007/s11033-014-3284-5
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AH8QY
UT WOS:000336404500065
PM 24570023
ER
PT J
AU McCarthy, SE
Gillis, J
Kramer, M
Lihm, J
Yoon, S
Berstein, Y
Mistry, M
Pavlidis, P
Solomon, R
Ghiban, E
Antoniou, E
Kelleher, E
O'Brien, C
Donohoe, G
Gill, M
Morris, DW
McCombie, WR
Corvin, A
AF McCarthy, S. E.
Gillis, J.
Kramer, M.
Lihm, J.
Yoon, S.
Berstein, Y.
Mistry, M.
Pavlidis, P.
Solomon, R.
Ghiban, E.
Antoniou, E.
Kelleher, E.
O'Brien, C.
Donohoe, G.
Gill, M.
Morris, D. W.
McCombie, W. R.
Corvin, A.
TI De novo mutations in schizophrenia implicate chromatin remodeling and
support a genetic overlap with autism and intellectual disability
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID SINGLE NUCLEOTIDE POLYMORPHISMS; GENOME-WIDE ASSOCIATION; BIPOLAR
DISORDER; L1 RETROTRANSPOSITION; SPECTRUM DISORDERS; SEQUENCING DATA;
HUMAN BRAIN; RISK LOCI; DISEASE; VARIANTS
AB Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have reinforced the hypothesis that rare genetic variation contributes to risk. We carried out exome sequencing on 57 trios with sporadic or familial schizophrenia. In sporadic trios, we observed a similar to 3.5-fold increase in the proportion of nonsense DNMs (0.101 vs 0.031, empirical P= 0.01, Benjamini-Hochberg-corrected P= 0.044). These mutations were significantly more likely to occur in genes with highly ranked probabilities of haploinsufficiency (P= 0.0029, corrected P= 0.006). DNMs of potential functional consequence were also found to occur in genes predicted to be less tolerant to rare variation (P= 2.01 x 10(-5), corrected P = 2.1 x 10(-3)). Genes with DNMs overlapped with genes implicated in autism (for example, AUTS2, CHD8 and MECP2) and intellectual disability (for example, HUWE1 and TRAPPC9), supporting a shared genetic etiology between these disorders. Functionally CHD8, MECP2 and HUWE1 converge on epigenetic regulation of transcription suggesting that this may be an important risk mechanism. Our results were consistent in an analysis of additional exome-based sequencing studies of other neurodevelopmental disorders. These findings suggest that perturbations in genes, which function in the epigenetic regulation of brain development and cognition, could have a central role in the susceptibility to, pathogenesis and treatment of mental disorders.
C1 [McCarthy, S. E.; Gillis, J.; Kramer, M.; Lihm, J.; Yoon, S.; Berstein, Y.; Solomon, R.; Ghiban, E.; Antoniou, E.; McCombie, W. R.] Cold Spring Harbor Lab, Stanley Inst Cognit Genom, Cold Spring Harbor, NY 11724 USA.
[Mistry, M.; Pavlidis, P.] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
[Mistry, M.; Pavlidis, P.] Univ British Columbia, Ctr High Throughput Biol, Vancouver, BC, Canada.
[Kelleher, E.; O'Brien, C.; Donohoe, G.; Gill, M.; Morris, D. W.; Corvin, A.] Univ Dublin Trinity Coll, Inst Mol Med, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 2, Ireland.
[McCombie, W. R.] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA.
RP McCarthy, SE (reprint author), Cold Spring Harbor Lab, Stanley Inst Cognit Genom, POB 100, Cold Spring Harbor, NY 11724 USA.
EM mccarthy@cshl.edu; mccombie@cshl.edu; acorvin@tcd.ie
FU Science Foundation Ireland [08/IN.1/B1916]; NIH [GM076990]; Michael
Smith Foundation for Health Research; Canadian Institutes for Health
Research
FX We would like to thank Stephanie Muller, Gloria Cheang, Senem Mavruk,
Manasa Kolli, Nabil Azamy, Anthony DeSantis and Patricia Mocombe for
contributing their expertise and help to perform exome capture,
sequencing, validations and genotyping. We are grateful to Elodie
Portales-Casamar for assistance with Neurocarta. We thank Jianchao Yao
for helpful discussion and feedback. Funding for this study was provided
by grants from T and V Stanley to SEM, JG, MK, JL, SY, YB, RS, EG, EA
and WRM and from Science Foundation Ireland (08/IN.1/B1916) to AC, MG
and DWM. PP was supported by NIH Grant GM076990 and salary awards from
the Michael Smith Foundation for Health Research and the Canadian
Institutes for Health Research. We thank James Watson for his constant
support and encouragement.
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
American Psychiatric Association Task Force, 1994, DIAGN STAT MAN MENT, Vxxvii
Baillie JK, 2011, NATURE, V479, P534, DOI 10.1038/nature10531
Barnett DW, 2011, BIOINFORMATICS, V27, P1691, DOI 10.1093/bioinformatics/btr174
Chun S, 2009, GENOME RES, V19, P1553, DOI 10.1101/gr.092619.109
Cingolani P, 2012, FLY, V6, P80, DOI 10.4161/fly.19695
Coufal NG, 2009, NATURE, V460, P1127, DOI 10.1038/nature08248
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Davydov EV, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1001025
de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Glaubitz JC, 2003, MOL ECOL, V12, P1039, DOI 10.1046/j.1365-294X.2003.01790.x
Goh KI, 2007, P NATL ACAD SCI USA, V104, P8685, DOI 10.1073/pnas.0701361104
Grayton HM, 2012, PROG NEUROBIOL, V99, P81, DOI 10.1016/j.pneurobio.2012.07.005
Green MR, 2012, MOL CLONING LAB MANU, VFourth
Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
Haldeman-Englert C, 1993, GENEREVIEWS
Houston I, 2013, NEUROPSYCHOPHARMACOL, V38, P183, DOI 10.1038/npp.2012.78
Huang N, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001154
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Strange A, 2012, BIOL PSYCHIAT, V72, P620, DOI 10.1016/j.biopsych.2012.05.035
Khurana E, 2013, PLOS COMPUT BIOL, V9, DOI 10.1371/journal.pcbi.1002886
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Kumar P, 2009, NAT PROTOC, V4, P1073, DOI 10.1038/nprot.2009.86
Lee SH, 2012, NAT GENET, V44, P247, DOI 10.1038/ng.1108
Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
Millar JK, 2000, HUM MOL GENET, V9, P1415, DOI 10.1093/hmg/9.9.1415
Morgan VA, 2012, BRIT J PSYCHIAT, V200, P282, DOI 10.1192/bjp.bp.111.093070
Muotri AR, 2010, NATURE, V468, P443, DOI 10.1038/nature09544
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Petrovski S, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003709
Portales-Casamar E, 2013, BMC GENOMICS, V14, DOI 10.1186/1471-2164-14-129
Pu SY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014122
Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
Ronan JL, 2013, NAT REV GENET, V14, P347, DOI 10.1038/nrg3413
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
Siepel A, 2006, LECT NOTES COMPUT SC, V3909, P190
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
Sullivan PF, 2012, ARCH GEN PSYCHIAT, V69, P1099, DOI 10.1001/archgenpsychiatry.2012.730
Sullivan PF, 2010, NEURON, V68, P182, DOI 10.1016/j.neuron.2010.10.003
Turinsky AL, 2011, NUCLEIC ACIDS RES, V39, pD889, DOI 10.1093/nar/gkq857
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Vogel C, 2006, PLOS COMPUT BIOL, V2, P370, DOI 10.1371/journal.pcbi.0020048
Walsh CA, 2010, NEURON, V68, P245, DOI 10.1016/j.neuron.2010.09.042
Wang K, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq603
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
Zoubarev A, 2012, BIOINFORMATICS, V28, P2272, DOI 10.1093/bioinformatics/bts430
NR 61
TC 12
Z9 13
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2014
VL 19
IS 6
BP 652
EP 658
DI 10.1038/mp.2014.29
PG 7
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AI2BZ
UT WOS:000336663100006
PM 24776741
ER
PT J
AU Di Martino, A
Yan, CG
Li, Q
Denio, E
Castellanos, FX
Alaerts, K
Anderson, JS
Assaf, M
Bookheimer, SY
Dapretto, M
Deen, B
Delmonte, S
Dinstein, I
Ertl-Wagner, B
Fair, DA
Gallagher, L
Kennedy, DP
Keown, CL
Keysers, C
Lainhart, JE
Lord, C
Luna, B
Menon, V
Minshew, NJ
Monk, CS
Mueller, S
Muller, RA
Nebel, MB
Nigg, JT
O'Hearn, K
Pelphrey, KA
Peltier, SJ
Rudie, JD
Sunaert, S
Thioux, M
Tyszka, JM
Uddin, LQ
Verhoeven, JS
Wenderoth, N
Wiggins, JL
Mostofsky, SH
Milham, MP
AF Di Martino, A.
Yan, C-G
Li, Q.
Denio, E.
Castellanos, F. X.
Alaerts, K.
Anderson, J. S.
Assaf, M.
Bookheimer, S. Y.
Dapretto, M.
Deen, B.
Delmonte, S.
Dinstein, I.
Ertl-Wagner, B.
Fair, D. A.
Gallagher, L.
Kennedy, D. P.
Keown, C. L.
Keysers, C.
Lainhart, J. E.
Lord, C.
Luna, B.
Menon, V.
Minshew, N. J.
Monk, C. S.
Mueller, S.
Mueller, R. A.
Nebel, M. B.
Nigg, J. T.
O'Hearn, K.
Pelphrey, K. A.
Peltier, S. J.
Rudie, J. D.
Sunaert, S.
Thioux, M.
Tyszka, J. M.
Uddin, L. Q.
Verhoeven, J. S.
Wenderoth, N.
Wiggins, J. L.
Mostofsky, S. H.
Milham, M. P.
TI The autism brain imaging data exchange: towards a large-scale evaluation
of the intrinsic brain architecture in autism
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE data sharing; default network; interhemispheric connectivity; intrinsic
functional connectivity; resting-state fMRI; thalamus
ID FUNCTIONAL CONNECTIVITY MRI; SPECTRUM DISORDERS; CORPUS-CALLOSUM;
REGIONAL-VARIATION; DEFAULT NETWORK; HEAD MOTION; ABNORMALITIES;
CHILDREN; SYSTEMS; UNDERCONNECTIVITY
AB Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we introduce the Autism Brain Imaging Data Exchange (ABIDE)-a grassroots consortium aggregating and openly sharing 1112 existing resting-state functional magnetic resonance imaging (R-fMRI) data sets with corresponding structural MRI and phenotypic information from 539 individuals with ASDs and 573 age-matched typical controls (TCs; 7-64 years) (http://fcon_ 1000. projects. nitrc. org/indi/abide/). Here, we present this resource and demonstrate its suitability for advancing knowledge of ASD neurobiology based on analyses of 360 male subjects with ASDs and 403 male age-matched TCs. We focused on whole-brain intrinsic functional connectivity and also survey a range of voxel-wise measures of intrinsic functional brain architecture. Whole-brain analyses reconciled seemingly disparate themes of both hypo-and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity. Exploratory analyses using an array of regional metrics of intrinsic brain function converged on common loci of dysfunction in ASDs (mid-and posterior insula and posterior cingulate cortex), and highlighted less commonly explored regions such as the thalamus. The survey of the ABIDE R-fMRI data sets provides unprecedented demonstrations of both replication and novel discovery. By pooling multiple international data sets, ABIDE is expected to accelerate the pace of discovery setting the stage for the next generation of ASD studies.
C1 [Di Martino, A.; Denio, E.; Castellanos, F. X.; Alaerts, K.] NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, NYU Child Study Ctr, New York, NY 10016 USA.
[Yan, C-G; Castellanos, F. X.; Milham, M. P.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
[Li, Q.; Milham, M. P.] Ctr Developing Brain, Child Mind Inst, New York, NY USA.
[Alaerts, K.; Wenderoth, N.] Katholieke Univ Leuven, Louvain, Belgium.
[Anderson, J. S.] Univ Utah, Div Neuroradiol, Salt Lake City, UT USA.
[Anderson, J. S.] Univ Utah, Interdept Program Neurosci, Salt Lake City, UT USA.
[Anderson, J. S.] Univ Utah, Inst Brain, Salt Lake City, UT USA.
[Anderson, J. S.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
[Assaf, M.] Hartford Hosp, Inst Living, Olin Neuropsychiatry Res Ctr, Hartford, CT 06115 USA.
[Assaf, M.; Deen, B.; Pelphrey, K. A.] Yale Univ, Sch Med, New Haven, CT USA.
[Bookheimer, S. Y.] Univ Calif Los Angeles, Ctr Cognit Neurosci, Los Angeles, CA USA.
[Bookheimer, S. Y.; Dapretto, M.; Rudie, J. D.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
[Bookheimer, S. Y.; Dapretto, M.; Rudie, J. D.] Univ Calif Los Angeles, Interdept Neurosci Program, Los Angeles, CA USA.
[Bookheimer, S. Y.; Rudie, J. D.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
[Dapretto, M.; Rudie, J. D.] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA USA.
[Deen, B.] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Delmonte, S.; Gallagher, L.] Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland.
[Delmonte, S.; Gallagher, L.] Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland.
[Dinstein, I.] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
[Dinstein, I.] Ben Gurion Univ Negev, Beer Sheva, Israel.
[Ertl-Wagner, B.; Mueller, S.] Univ Munich, Inst Clin Radiol, Munich, Germany.
[Fair, D. A.] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA.
[Fair, D. A.] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA.
[Fair, D. A.] Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97201 USA.
[Kennedy, D. P.] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
[Kennedy, D. P.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA.
[Keown, C. L.; Mueller, R. A.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
[Keysers, C.; Thioux, M.] Royal Dutch Acad Sci KNAW, Netherlands Inst Neurosci, Amsterdam, Netherlands.
[Keysers, C.; Thioux, M.] Univ Groningen, Univ Med Ctr Groningen, BCN NeuroImaging Ctr, NL-9713 AV Groningen, Netherlands.
[Lainhart, J. E.] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI USA.
[Lainhart, J. E.] Univ Wisconsin, Dept Psychiat, Div Child & Adolescent Psychiat, Madison, WI 53706 USA.
[Lord, C.] Weill Cornell Med Coll, New York, NY USA.
[Luna, B.; O'Hearn, K.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
[Menon, V.; Uddin, L. Q.] Stanford Univ, Stanford, CA 94305 USA.
[Minshew, N. J.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
[Minshew, N. J.] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA.
[Monk, C. S.; Peltier, S. J.; Wiggins, J. L.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Nebel, M. B.; Mostofsky, S. H.] Kennedy Krieger Inst, Lab Neurocognit & Imaging Res, Baltimore, MD USA.
[Nigg, J. T.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Sunaert, S.; Verhoeven, J. S.] Katholieke Univ Leuven, Univ Leuven, Translat MRI, Louvain, Belgium.
[Tyszka, J. M.] CALTECH, Div Biol, Pasadena, CA 91125 USA.
[Mostofsky, S. H.] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
[Mostofsky, S. H.] Johns Hopkins Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.
RP Di Martino, A (reprint author), NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, NYU Child Study Ctr, One Pk Ave,8th Floor, New York, NY 10016 USA.
EM dimara01@nyumc.org; michael.milham@childmind.org
RI Monk, Christopher/J-1805-2014; Milham, Michael/K-9501-2014; Di Martino,
Adriana/L-2497-2014; Tyszka, Julian/O-3498-2014; Yan,
Chao-Gan/D-1713-2015; Nebel, Mary Beth/D-3305-2015; Wenderoth,
Nicole/D-7262-2015
OI Tyszka, Julian/0000-0001-9342-9014; Yan, Chao-Gan/0000-0003-3413-5977;
Nebel, Mary Beth/0000-0003-0185-3382; Wenderoth,
Nicole/0000-0002-3246-9386
FU NIMH [K23MH087770, R03MH09632, BRAINSRO1MH094639-01]; Leon Levy
Foundation; Joseph P Healey and the Stavros Niarchos Foundation; NIH
[DC011095, MH084164, K01MH092288-Stanford, HD55748, KO1MH081191,
MH67924-Pitt, K08MH092697, P50MH60450, R01NS34783, R01MH080826,
T32DC008553-USM, R01HD065282, R21MH084126-NYU, MH066496, R21MH079871,
U19HD035482-UM1&UM2, R00MH091238, R01MH086654, R01MH096773-OHSU,
R01MH081023-SDSU;, 1R01HD06528001-UCLA1 and -UCLA2;, K01MH071284-Yale,
R01MH080721, K99/R00MH094409-Caltech]; NINDS [R01NS048527]; NICHD (Yale)
[P50 HD055784, UCLA1 and 2]; NICHD/NIDCD [P01/U19]; the Simons
Foundation (OHSU, Yale, Caltech, CMU); the Belgian Interuniversity
Attraction Poles [P6/29, Leuven 1 and 2]; Ben B and Iris M Margolis
Foundation; European Commission; Marie Curie Excellence
[MEXT-CT-2005-023253]; Flanders Fund for Scientific Research [Leuven 1
and 2, 1841313N, G.0354.06, G.0758.10, post-doc grant]; Hartford
Hospital (Olin); John Merck Scholars Fund (Yale); Kyulan Family
Foundation (Trinity); Michigan Institute for Clinical and Health
Research (MICHR) Predoctoral Fellowship [UM1 and 2]; The Meath
Foundation, Adelaide & Meath Hospital (AMNCH; Trinity); National
Initiative for Brain and Cognition NIHC HCMI [056-13-014, 056-13-017];
NWO [051.07.003, 452-04-305, 400-08-089]; Netherlands Brain Foundation
[KS 2010(1)-29]; NRSA Pre-doctoral Fellowship [F31DC010143]; Research
Research Council of the University of Leuven [Leuven 1 and 2]; Singer
Foundation and Stanford Institute for Neuro-Innovations and
Translational Neurosciences (Stanford); Leon Levy Foundation (NYU);
Stavros Niarchos Foundation (NYU); UCLA Autism Center of Excellence
[UCLA1 and 2]; Autism Science Foundation (Yale); University of Utah
Multidisciplinary Research Seed Grant (USM); [R01MH081218]
FX We thank the numerous contributors at each site (see Supplementary Table
2 and http://fcon_1000.projects.nitrc.org/indi/abide/), particularly Drs
Marlene Behrmann and Leonardo Cerliani for their efforts in the
collection, organization and sharing of their data sets; the NITRC
(http://www.nitrc.org) for providing the data sharing platform for the
ABIDE initiative as well as the other informatics databases for
providing additional platforms (see
http://fcon_1000.projects.nitrc.org/indi/abide). We also thank Ranjit
Khanuja and Sharad Sikka for programming support; Dr R Cameron Craddock
for invaluable suggestions regarding data analysis, as well as oversight
of the development of the Configurable Pipeline for the Analysis of
Connectomes, and Drs Zhen Yang and Clare Kelly for suggestions on
earlier versions of this manuscript. Support for ABIDE coordination and
data aggregation was partially provided by NIMH (K23MH087770, R03MH09632
and BRAINSRO1MH094639-01), the Leon Levy Foundation and by gifts from
Joseph P Healey and the Stavros Niarchos Foundation. Support for data
collection at each site was provided by NIH (DC011095, MH084164,
K01MH092288-Stanford; HD55748, KO1MH081191, MH67924-Pitt; K08MH092697,
P50MH60450, R01NS34783, R01MH080826, T32DC008553-USM; K23MH087770,
R01HD065282, R01MH081218, R21MH084126-NYU; MH066496, R21MH079871,
U19HD035482-UM1 & UM2; R00MH091238, R01MH086654, R01MH096773-OHSU;
R01MH081023-SDSU; 1R01HD06528001-UCLA1 and -UCLA2; K01MH071284-Yale;
R01MH080721; K99/R00MH094409-Caltech), Autism Speaks (KKI, NYU, Olin,
UM1and 2, Pitt, USM, Yale), NINDS (R01NS048527; KKI), NICHD (Yale) NICHD
(P50 HD055784; UCLA1 and 2), NICHD/NIDCD (P01/U19; CMU) the Simons
Foundation (OHSU, Yale, Caltech, CMU), the Belgian Interuniversity
Attraction Poles Grant (P6/29; Leuven 1 and 2), Ben B and Iris M
Margolis Foundation (USM), European Commission, Marie Curie Excellence
Grant (MEXT-CT-2005-023253; SBL), Flanders Fund for Scientific Research
(1841313N, G.0354.06, G.0758.10; and post-doc grant; Leuven 1 and 2),
Hartford Hospital (Olin), John Merck Scholars Fund (Yale), Kyulan Family
Foundation (Trinity), Michigan Institute for Clinical and Health
Research (MICHR) Predoctoral Fellowship (UM1 and 2), The Meath
Foundation, Adelaide & Meath Hospital, Dublin Incorporating the National
Children's Hospital (AMNCH; Trinity), National Initiative for Brain and
Cognition NIHC HCMI (056-13-014, 056-13-017; SBL), NWO (051.07.003,
452-04-305, 400-08-089; SBL) and Netherlands Brain Foundation
(KS2010(1)-29; SBL), NRSA Pre-doctoral Fellowship (F31DC010143; USM),
Research Council of the University of Leuven (Leuven 1 and 2), Singer
Foundation and Stanford Institute for Neuro-Innovations and
Translational Neurosciences (Stanford), Leon Levy fOundation (NYU),
Stavros Niarchos Foundation (NYU), UCLA Autism Center of Excellence
(UCLA1 and 2), Autism Science Foundation (Yale) and University of Utah
Multidisciplinary Research Seed Grant (USM).
CR ADHD-200 Consortium, 2012, FRONT SYST NEUROSCI, V6, P1
Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
Andrews-Hanna JR, 2010, NEURON, V65, P550, DOI 10.1016/j.neuron.2010.02.005
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Banich MT, 1998, BRAIN COGNITION, V36, P128, DOI 10.1006/brcg.1997.0950
Behzadi Y, 2007, NEUROIMAGE, V37, P90, DOI 10.1016/j.neuroimage.2007.04.042
Biswal BB, 2010, P NATL ACAD SCI USA, V107, P4734, DOI 10.1073/pnas.0911855107
Buckner RL, 2009, J NEUROSCI, V29, P1860, DOI 10.1523/JNEUROSCI.5062-08.2009
Bullmore ET, 2009, NAT REV NEUROSCI, V10, P186, DOI 10.1038/nrn2575
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Cheon KA, 2011, BRAIN RES, V1417, P77, DOI 10.1016/j.brainres.2011.08.020
Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
Craddock RC, 2012, HUM BRAIN MAPP, V33, P1914, DOI 10.1002/hbm.21333
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Di Martino A, 2009, AM J PSYCHIAT, V166, P891, DOI 10.1176/appi.ajp.2009.08121894
Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026
Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
Fair Damien A, 2012, Front Syst Neurosci, V6, P80, DOI 10.3389/fnsys.2012.00080
Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotts SJ, 2012, BRAIN, V135, P2711, DOI 10.1093/brain/aws160
Hall D, 2012, NEUROINFORMATICS, V10, P331, DOI 10.1007/s12021-012-9151-4
Hardan AY, 2009, PSYCHIAT RES-NEUROIM, V174, P57, DOI 10.1016/j.pscychresns.2009.03.005
Hong SS, 2011, PSYCHIAT RES-NEUROIM, V194, P333, DOI 10.1016/j.pscychresns.2011.03.009
Jones TB, 2010, NEUROIMAGE, V49, P401, DOI 10.1016/j.neuroimage.2009.07.051
Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
Kelly C, 2012, TRENDS COGN SCI, V16, P181, DOI 10.1016/j.tics.2012.02.001
Kennedy DN, 1998, CEREB CORTEX, V8, P372, DOI 10.1093/cercor/8.4.372
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
Kennedy DP, 2008, SOC COGN AFFECT NEUR, V3, P177, DOI 10.1093/scan/nsn011
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Lai MC, 2010, BIOL PSYCHIAT, V68, P1092, DOI 10.1016/j.biopsych.2010.06.027
Lewis JD, 2013, HUM BRAIN MAPP, V34, P1685, DOI 10.1002/hbm.22018
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Mennes M, 2012, NEUROIMAGE, DOI [10.1016/j.neuroimage.2012.10.064, DOI 10.1016/J.NEUR0IMAGE.2012.10.064]
Mesulam MM, 1998, BRAIN, V121, P1013, DOI 10.1093/brain/121.6.1013
Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Moreno-De-Luca D, 2013, MOL PSYCHIATR, V18, P1090, DOI 10.1038/mp.2012.138
Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
Paakki JJ, 2010, BRAIN RES, V1321, P169, DOI 10.1016/j.brainres.2009.12.081
Piven J, 1997, AM J PSYCHIAT, V154, P1051
Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020
Rudie JD, 2012, CEREB CORTEX, V22, P1025, DOI 10.1093/cercor/bhr171
Satterthwaite TD, 2012, NEUROIMAGE, V60, P623, DOI 10.1016/j.neuroimage.2011.12.063
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Shehzad Z, 2009, CEREB CORTEX, V19, P2209, DOI 10.1093/cercor/bhn256
Shukla DK, 2010, J AM ACAD CHILD PSY, V49, P1269, DOI 10.1016/j.jaac.2010.08.018
Stark DE, 2008, J NEUROSCI, V28, P13754, DOI 10.1523/JNEUROSCI.4544-08.2008
Supekar K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000157
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Tomasi D, 2012, BIOL PSYCHIAT, V71, P443, DOI 10.1016/j.biopsych.2011.11.003
Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002
Van Dijk KRA, 2010, J NEUROPHYSIOL, V103, P297, DOI 10.1152/jn.00783.2009
Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Yan C, 2010, FRONT SYST NEUROSCI, V4, P13, DOI DOI 10.3389/FNSYS.2010.00013
Yan CG, 2013, NEUROIMAGE, V76, P183, DOI 10.1016/j.neuroimage.2013.03.004
Zang YF, 2004, NEUROIMAGE, V22, P394, DOI 10.1016/j.neuroimage.2003.12.030
Zuo XN, 2010, J NEUROSCI, V30, P15034, DOI 10.1523/JNEUROSCI.2612-10.2010
Zuo XN, 2010, NEUROIMAGE, V49, P1432, DOI 10.1016/j.neuroimage.2009.09.037
Zuo XN, 2012, CEREB CORTEX, V22, P1862, DOI 10.1093/cercor/bhr269
NR 75
TC 26
Z9 26
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2014
VL 19
IS 6
BP 659
EP 667
DI 10.1038/mp.2013.78
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AI2BZ
UT WOS:000336663100007
PM 23774715
ER
PT J
AU McCarro, SA
Feng, GP
Hyman, SE
AF McCarro, Steven A.
Feng, Guoping
Hyman, Steven E.
TI Genome-scale neurogenetics: methodology and meaning
SO NATURE NEUROSCIENCE
LA English
DT Article
ID DE-NOVO MUTATIONS; ALZHEIMERS-DISEASE; GENETIC-VARIATION;
PSYCHIATRIC-DISORDERS; POPULATION-SCALE; RISK LOCI; AUTISM;
SCHIZOPHRENIA; ASSOCIATION; COMMON
AB Genetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.
C1 [McCarro, Steven A.; Feng, Guoping; Hyman, Steven E.] Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.
[McCarro, Steven A.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
[Feng, Guoping] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA.
[Feng, Guoping] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Hyman, Steven E.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA.
RP McCarro, SA (reprint author), Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.
EM mccarroll@genetics.med.harvard.edu; stevehy@broadinstitute.org
FU Stanley Medical Research Institute
FX The authors are supported by the Stanley Medical Research Institute.
CR Altshuler DM, 2012, NATURE, V491, P56, DOI 10.1038/nature11632
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bauer DE, 2013, SCIENCE, V342, P253, DOI 10.1126/science.1242088
Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
Berrettini WH, 2000, BIOL PSYCHIAT, V48, P531, DOI 10.1016/S0006-3223(00)00883-0
Cohen Jonathan, 2005, Nature Genetics, V37, P161, DOI 10.1038/ng1509
Consortium TIS, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Fromer M, 2014, NATURE, V506, P179, DOI 10.1038/nature12929
Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
Cong L, 2013, SCIENCE, V339, P819, DOI 10.1126/science.1231143
Handsaker RE, 2011, NAT GENET, V43, P269, DOI 10.1038/ng.768
Hyman SE, 2007, NAT REV NEUROSCI, V8, P725, DOI 10.1038/nrn2218
Hyman SE, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003142
Altshuler DM, 2010, NATURE, V467, P52, DOI 10.1038/nature09298
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jack CR, 2013, NEURON, V80, P1347, DOI 10.1016/j.neuron.2013.12.003
Jonsson T, 2012, NATURE, V488, P96, DOI 10.1038/nature11283
Karayiorgou M, 2012, NAT NEUROSCI, V15, P811, DOI 10.1038/nn.3115
Lambert JC, 2013, NAT GENET, V45, P1452, DOI 10.1038/ng.2802
Lee SH, 2013, NAT GENET, V45, P984, DOI 10.1038/ng.2711
Li Y, 2009, ANNU REV GENOM HUM G, V10, P387, DOI 10.1146/annurev.genom.9.081307.164242
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Mali P, 2013, SCIENCE, V339, P823, DOI 10.1126/science.1232033
McCarroll SA, 2008, NAT GENET, V40, P1107, DOI 10.1038/ng.215
Musunuru K, 2010, NATURE, V466, P714, DOI 10.1038/nature09266
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
Okano H, 2012, SEMIN FETAL NEONAT M, V17, P336, DOI 10.1016/j.siny.2012.07.002
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
PREUSS TM, 1995, J COGNITIVE NEUROSCI, V7, P1, DOI 10.1162/jocn.1995.7.1.1
Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011, NAT GENET, V43, P977
Purcell SM, 2014, NATURE, V506, P185, DOI 10.1038/nature12975
Rees E, 2014, BRIT J PSYCHIAT, V204, P108, DOI 10.1192/bjp.bp.113.131052
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
The 1000 Genomes Project Consortium, 2010, NATURE, V467, P1061
Altshuler D, 2005, NATURE, V437, P1299, DOI 10.1038/nature04226
Volk DW, 2010, CURR TOP BEHAV NEURO, V4, P485, DOI 10.1007/7854_2010_44
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104
World Health Organisation, 1992, ICD 10 CLASS MENT BE
Yang JA, 2010, NAT GENET, V42, P565, DOI 10.1038/ng.608
Zuk O, 2014, P NATL ACAD SCI USA, V111, pE455, DOI 10.1073/pnas.1322563111
NR 47
TC 3
Z9 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
EI 1546-1726
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD JUN
PY 2014
VL 17
IS 6
BP 756
EP 763
DI 10.1038/nn.3716
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA AI1TO
UT WOS:000336638000008
PM 24866041
ER
PT J
AU Goffin, D
Brodkin, ES
Blendy, JA
Siegel, SJ
Zhou, ZL
AF Goffin, Darren
Brodkin, Edward S.
Blendy, Julie A.
Siegel, Steve J.
Zhou, Zhaolan
TI Cellular origins of auditory event-related potential deficits in Rett
syndrome
SO NATURE NEUROSCIENCE
LA English
DT Article
ID GABAERGIC NEURONS; MOUSE MODEL; PHENOTYPES; CORTEX; MECP2; MICE
AB Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits.
C1 [Goffin, Darren; Zhou, Zhaolan] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA.
[Brodkin, Edward S.; Siegel, Steve J.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Blendy, Julie A.] Univ Penn, Dept Pharmacol, Perelman Sch Med, Philadelphia, PA 19104 USA.
RP Zhou, ZL (reprint author), Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA.
EM zhaolan@maiLmed.upenn.edu
FU US National Institutes of Health [R01 NS081054, R01 MH091850];
International Rett Syndrome Foundation
FX We thank members of the Zhou laboratory for critical reading of the
manuscript. This work was supported by US National Institutes of Health
grants R01 NS081054 and R01 MH091850 (Z.Z.) and the International Rett
Syndrome Foundation (Z.Z. and D.G.). Z.Z. is a Pew Scholar in Biomedical
Sciences.
CR Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
Gentet LJ, 2012, NAT NEUROSCI, V15, P607, DOI 10.1038/nn.3051
Goffin Darren, 2012, [Frontiers in Biology, 生物学前沿], V7, P428
Goffin D, 2012, NAT NEUROSCI, V15, P274, DOI 10.1038/nn.2997
Gong SC, 2007, J NEUROSCI, V27, P9817, DOI 10.1523/JNEUROSCI.2707-07.2007
Gorski JA, 2002, J NEUROSCI, V22, P6309
Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
Hardisty-Hughes RE, 2010, NAT PROTOC, V5, P177, DOI 10.1038/nprot.2009.204
Isaacson JS, 2011, NEURON, V72, P231, DOI 10.1016/j.neuron.2011.09.027
Katz DM, 2012, DIS MODEL MECH, V5, P733, DOI 10.1242/dmm.011007
Lee SH, 2012, NATURE, V488, P379, DOI 10.1038/nature11312
Liao WL, 2012, NEUROBIOL DIS, V46, P88, DOI 10.1016/j.nbd.2011.12.048
Madisen L, 2010, NAT NEUROSCI, V13, P133, DOI 10.1038/nn.2467
Monory K, 2006, NEURON, V51, P455, DOI 10.1016/j.neuron.2006.07.006
Taniguchi H, 2011, NEURON, V71, P995, DOI 10.1016/j.neuron.2011.07.026
Uhlhaas PJ, 2012, NEURON, V75, P963, DOI 10.1016/j.neuron.2012.09.004
Ward CS, 2011, J NEUROSCI, V31, P10359, DOI 10.1523/JNEUROSCI.0057-11.2011
Zhao YT, 2013, NEUROBIOL DIS, V59, P257, DOI 10.1016/j.nbd.2013.08.001
NR 20
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
EI 1546-1726
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD JUN
PY 2014
VL 17
IS 6
BP 804
EP 806
DI 10.1038/nn.3710
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA AI1TO
UT WOS:000336638000014
PM 24777420
ER
PT J
AU Sokolov, O
Kost, N
Andreeva, O
Korneeva, E
Meshavkin, V
Tarakanova, Y
Dadayan, A
Zolotarev, Y
Grachev, S
Mikheeva, I
Varlamov, O
Zozulya, A
AF Sokolov, Oleg
Kost, Natalya
Andreeva, Olga
Korneeva, Ekaterina
Meshavkin, Viktor
Tarakanova, Yulia
Dadayan, Aleksander
Zolotarev, Yurii
Grachev, Sergei
Mikheeva, Inna
Varlamov, Oleg
Zozulya, Andrey
TI Autistic children display elevated urine levels of bovine casomorphin-7
immunoreactivity
SO PEPTIDES
LA English
DT Article
DE Autism; Urine; Bovine casomorphin; Opioid peptides
ID BLOOD MONONUCLEAR-CELLS; BETA-ENDORPHIN LEVELS; DIPEPTIDYL-PEPTIDASE;
OPIOID-PEPTIDES; CHILDHOOD; DISORDER
AB Elevated concentrations of circulating casomorphins (CM), the exogenous opioid peptides from milk casein, may contribute to the pathogenesis of autism in children. Because several mass spectrometry studies failed to detect casomorphins in autistic children, it was questioned whether these peptides can be detected in body fluids by mass spec. Here we demonstrated, using a novel high sensitivity ELISA method, that autistic children have significantly higher levels of urine CM-7 than control children. The severity of autistic symptoms correlated with concentrations of CM-7 in the urine. Because CMs interact with opioid and serotonin receptors, the known modulators of synaptogenesis, we suggest that chronic exposure to elevated levels of bovine CMs may impair early child development, setting the stage for autistic disorders. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Sokolov, Oleg; Kost, Natalya; Andreeva, Olga; Meshavkin, Viktor; Tarakanova, Yulia; Zozulya, Andrey] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia.
[Korneeva, Ekaterina; Mikheeva, Inna] Russian State Med Univ, Moscow 117437, Russia.
[Dadayan, Aleksander; Zolotarev, Yurii] RAS, Inst Mol Genet, Moscow 117901, Russia.
[Grachev, Sergei] RAS, Inst Bioorgan Chem, Moscow 117901, Russia.
[Varlamov, Oleg] Oregon Natl Primate Res Ctr, Beaverton, OR USA.
RP Sokolov, O (reprint author), Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia.
EM oleg-sokolov@yandex.ru
FU Russian Fund of Fundamental Research [06-04-08257, 10-04-01781-a]
FX This work was supported by the grant of Russian Fund of Fundamental
Research 06-04-08257 and 10-04-01781-a.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Arrons M, 1999, AUTISTIC SPECTRUM HD
Brambilla F, 1997, NEUROPSYCHOBIOLOGY, V35, P1, DOI 10.1159/000119322
Dettmer K, 2008, ANAL BIOANAL CHEM, V388, P1643
GILLBERG C, 1985, ARCH GEN PSYCHIAT, V42, P780
Gillberg C, 2004, 16 WORLD C INT ASS C
Cazzullo AG, 1999, EUR NEUROPSYCHOPHARM, V9, P361
Hunter LC, 2003, DEV MED CHILD NEUROL, V45, P121, DOI 10.1017/S0012162203000227
Jarmolowska B, 2007, PEPTIDES, V28, P678, DOI 10.1016/j.peptides.2006.11.014
Kost NV, 2009, PEPTIDES, V30, P1854, DOI 10.1016/j.peptides.2009.06.025
Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5
Leboyer M., 1993, Encephale, V19, P95
Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048
Manzi B, 2008, J CHILD NEUROL, V23, P307, DOI 10.1177/0883073807308698
Muhle R., 2004, PEDIATRICS, V113, P472
Muller RA, 2007, MENT RETARD DEV D R, V13, P85, DOI 10.1002/mrdd.20141
Nagamitsu S, 1997, J AUTISM DEV DISORD, V27, P155, DOI 10.1023/A:1025839807431
PANKSEPP J, 1979, TRENDS NEUROSCI, V2, P174, DOI 10.1016/0166-2236(79)90071-7
Pedersen L, 2013, NUTR NEUROSCI
Pennesi CM, 2012, NUTR NEUROSCI, V15, P85, DOI 10.1179/1476830512Y.0000000003
Reichelt K L, 1981, Adv Biochem Psychopharmacol, V28, P627
Reichelt KL, 2012, MICROB ECOL HLTH DIS
Reichelt KL, 2009, ANN CLIN PSYCHIATRY, V21, P205
Rodney RD, 2011, EMERG HLTH THREATS J, V4
RUTHRICH HL, 1992, PEPTIDES, V13, P69, DOI 10.1016/0196-9781(92)90141-O
Shattock Paul, 2002, Expert Opin Ther Targets, V6, P175
Sokolov OY, 2006, PROTEIN PEPTIDE LETT, V13, P169, DOI 10.2174/092986606775101733
Sokolov OY, 2005, BYULL EKSP BIOL MED, V11, P595
Sponheim Eili, 2006, Tidsskr Nor Laegeforen, V126, P1475
Stovolosov IS, 2011, B EXP BIOL MED+, V150, P281, DOI 10.1007/s10517-011-1123-4
Tagore DM, 2009, NAT CHEM BIOL, V5, P23, DOI 10.1038/nchembio.126
Tiganov AS, 2005, Z NEVROL PSIKHIATRII, V105, P4
TIRUPPATHI C, 1990, J BIOL CHEM, V265, P1476
Tordjman S, 2009, PLOS ONE, V4, P5289
Vojdani A, 2004, CLIN DIAGN LAB IMMUN, V11, P515, DOI 10.1128/CDLI.11.3.515-524.2004
Whiteley P, 2010, NUTR NEUROSCI, V13, P87, DOI 10.1179/147683010X12611460763922
ZIOUDROU C, 1979, J BIOL CHEM, V254, P2446
Zozulya A. A., 2009, Eksperimental'naya i Klinicheskaya Farmakologiya, V72, P3
NR 38
TC 3
Z9 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD JUN
PY 2014
VL 56
BP 68
EP 71
DI 10.1016/j.peptides.2014.03.007
PG 4
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA AI0FL
UT WOS:000336521500009
PM 24657283
ER
PT J
AU McCracken, JT
Badashova, KK
Posey, DJ
Aman, MG
Scahill, L
Tierney, E
Arnold, LE
Vitiello, B
Whelan, F
Chuang, SZ
Davies, M
Shah, B
McDougle, CJ
Nurmi, EL
AF McCracken, J. T.
Badashova, K. K.
Posey, D. J.
Aman, M. G.
Scahill, L.
Tierney, E.
Arnold, L. E.
Vitiello, B.
Whelan, F.
Chuang, S. Z.
Davies, M.
Shah, B.
McDougle, C. J.
Nurmi, E. L.
TI Positive effects of methylphenidate on hyperactivity are moderated by
monoaminergic gene variants in children with autism spectrum disorders
SO PHARMACOGENOMICS JOURNAL
LA English
DT Article
DE autism spectrum disorders; dopamine; genetics; hyperactivity;
methylphenidate
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL
DISORDERS; DOPAMINE TRANSPORTER GENOTYPE; ABERRANT BEHAVIOR CHECKLIST;
ADHD CHILDREN; DOSE-RESPONSE; RECEPTOR GENE; SCHIZOPHRENIC CHILDREN;
GENOME BROWSER; ASSOCIATION
AB Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely. We hypothesized monoaminergic gene variants may moderate MPH effects in ASD, as in typically developing children with attention-deficit/hyperactivity disorder. Genotype data were available for 64 children with ASD and hyperactivity who were exposed to MPH during a 1-week safety/tolerability lead-in phase and 58 who went on to be randomized to placebo and three doses of MPH during a 4-week blinded, crossover study. Outcome measures included the Clinical Global Impression-Improvement (CGI-I) scale and the Aberrant Behavior Checklist (ABC-hyperactivity index). A total of 14 subjects discontinued the study because of MPH side effects. Subjects were genotyped for variants in DRD1-DRD5, ADRA2A, SLC6A3, SLC6A4, MAOA and MAOB, and COMT. Forty-nine percent of the sample met positive responder criteria. In this modest but relatively homogeneous sample, significant differences by DRD1 (P=0.006), ADRA2A (P<0.02), COMT (P< 0.04), DRD3 (P<0.05), DRD4 (P<0.05), SLC6A3 (P<0.05) and SLC6A4 (P<0.05) genotypes were found for responders versus non-responders. Variants in DRD2 (P<0.001) and DRD3 (P<0.04) were associated with tolerability in the 14 subjects who discontinued the trial. For this first MPH pharmacogenetic study in children with ASD, multiple monoaminergic gene variants may help explain individual differences in MPH's efficacy and tolerability.
C1 [McCracken, J. T.; Badashova, K. K.; Whelan, F.; Shah, B.; Nurmi, E. L.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci, Los Angeles, CA 90024 USA.
[Posey, D. J.] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
[Aman, M. G.; Arnold, L. E.] Ohio State Univ, Nisonger Ctr UCEDD, Dept Psychiat, Columbus, OH 43210 USA.
[Aman, M. G.; Arnold, L. E.] Ohio State Univ, Nisonger Ctr UCEDD, Dept Psychol, Columbus, OH 43210 USA.
[Scahill, L.] Yale Univ, Child Study Ctr, New Haven, CT USA.
[Tierney, E.] Johns Hopkins Univ, Kennedy Krieger Inst, Dept Psychiat, Baltimore, MD USA.
[Vitiello, B.] NIMH, NIH, Bethesda, MD 20892 USA.
[Chuang, S. Z.; Davies, M.] Columbia Univ, Dept Psychiat, New York, NY USA.
[McDougle, C. J.] Massachusetts Gen Hosp, Lurie Autism Ctr, Dept Psychiat, Boston, MA 02114 USA.
RP McCracken, JT (reprint author), UCLA NPI Semel Inst, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA.
EM jmccracken@mednet.ucla.edu
RI Nurmi, Erika/P-4627-2014
OI Nurmi, Erika/0000-0003-4893-8957
FU NIMH [N01 MH-70070, N01 MH-70009, N01 MH-70001, N01 MH 80011, MH-01805,
MH094613, T32MH073517, MH-68627]; NIH Division of Research Resources
General Clinical Research Center [M01 RR-00750, M01 RR-00052, M01
RR-00034, M01 RR-06022]; Korczak Foundation
FX The RUPP Autism Network comprises the following investigators listed by
role and study site: Ohio State University: principal investigator
Michael G Amen, PhD, co-investigators L Eugene Arnold, MEd, MD, Yaser
Ramadan, MD, Andrea Witwer, MA, Ronald Lindsay, MD and Patricia Nash,
MD; University of California at Los Angeles: principal investigator
James T McCracken, MD, co-investigators Bhavik Shah, MD, James Mc Gough,
MD, Pegeen Cronin, PhD, Lisa Lee, BA; Indiana University: principal
investigator Christopher J McDougle, MD, co-investigators David Posey,
MD, Naomi Swiezy, PhD, Arlene Kohn, BA; Yale University: principal
investigator Lawrence Scahill, MSN, PhD, co-investigators Andres Martin,
MD, Kathleen Koenig, MSN, Fred Volkmar, MD, Deirdre Carroll, MSN,
Allison Lancor, BS; Kennedy Krieger Institute: principal investigator
Elaine Tierney, MD, co-investigators Jaswinder Ghuman, MD, Nilda
Gonzalez, MD, Marco Grados, MD; National Institute of Mental Health:
principal investigator Benedetto Vitiello, MD, co-investigator Louise
Ritz, MBA; statisticians: Shirley Z Chuang, MS, Mark Davies, MPH, of
Columbia University; data management: James Robinson, MEd, Don McMahon,
MS, Nathan Kline Institute. Research supported by NIMH contracts N01
MH-70070 (principal investigator: Dr McCracken), N01 MH-70009 (principal
investigator: Dr Scahill), N01 MH-70001 (principal investigator: Dr
McDougle), and N01 MH 80011 (principal investigator: Dr Amen); by NIH
Division of Research Resources General Clinical Research Center grants
M01 RR-00750 (to Indiana University), M01 RR-00052 (to John Hopkins
University), M01 RR-00034 (to Ohio University) and M01 RR-06022 (to Yale
University); by NIMH grants MH-01805 (to Dr McCracken) NIMH grants
MH094613 and T32MH073517 (Dr Nurmi) and MH-68627 (to Dr Posey); and by
funding from the Korczak Foundation (to Dr Scahill). The opinions and
assertions contained in this report are the private views of the authors
and are not to be construed as official or as reflecting the views of
the National Institute of Mental Health, the National Institutes of
Health, or the Department of Health and Human Services.
CR Alfimova M V, 2007, Neurosci Behav Physiol, V37, P643, DOI 10.1007/s11055-007-0064-x
AMAN MG, 1985, AM J MENT DEF, V89, P485
Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P116, DOI 10.1089/cap.2005.15.116
AMAN MG, 1985, AM J MENT DEF, V89, P492
Arnsten AFT, 2011, BIOL PSYCHIAT, V69, pE89, DOI 10.1016/j.biopsych.2011.01.027
Bakker PR, 2006, SCHIZOPHR RES, V83, P185, DOI 10.1016/j.schres.2006.01.010
Barrett JC, 2005, BIOINFORMATICS, V21, P263
Bobb AJ, 2005, AM J MED GENET B, V134B, P67, DOI 10.1002/ajmg.b.30142
Bobb AJ, 2005, AM J MED GENET B, V132B, P109, DOI 10.1002/ajmg.b.30086
CAMPBELL M, 1972, J AUTISM CHILD SCHIZ, V2, P343, DOI 10.1007/BF01538168
CAMPBELL M, 1976, CURR THER RES CLIN E, V19, P70
CDC (Cent. Dis. Control Prev.), 2007, MMWR SURVEILL SUMM, V56, P12
Cheon KA, 2007, NEUROPSYCHOPHARMACOL, V32, P1377, DOI 10.1038/sj.npp.1301244
Cheon KA, 2008, INT CLIN PSYCHOPHARM, V23, P291, DOI 10.1097/YIC.0b013e328306a977
COOK EH, 1995, AM J HUM GENET, V56, P993
Dailey J. W., 2004, NEUROSCI BIOBEHAV R, V28, P771
da Silva TL, 2008, J NEURAL TRANSM, V115, P341, DOI 10.1007/s00702-007-0835-0
de Frias CM, 2005, J COGNITIVE NEUROSCI, V17, P1018
Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
Faraone SV, 2005, BIOL PSYCHIAT, V57, P1313, DOI 10.1016/j.biopsych.2004.11.024
Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
Froehlich TE, 2011, J AM ACAD CHILD PSY, V50, P1129, DOI 10.1016/j.jaac.2011.08.002
Gainetdinov RR, 1999, SCIENCE, V283, P397, DOI 10.1126/science.283.5400.397
GILLBERG C, 1987, BRIT J PSYCHIAT, V151, P89, DOI 10.1192/bjp.151.1.89
Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
Greenhill LL, 1996, J AM ACAD CHILD PSY, V35, P1304, DOI 10.1097/00004583-199610000-00017
Gruber R, 2009, J CHILD ADOL PSYCHOP, V19, P233, DOI 10.1089/cap.2008.0133
Guiard BP, 2008, MOL PHARMACOL, V74, P1463, DOI 10.1124/mol.108.048033
Hamarman S, 2004, J CHILD ADOL PSYCHOP, V14, P564, DOI 10.1089/cap.2004.14.564
Handen BL, 2000, J AUTISM DEV DISORD, V30, P245, DOI 10.1023/A:1005548619694
Kent WJ, 2002, GENOME RES, V12, P996, DOI 10.1101/gr.229102
Kereszturi E, 2008, AM J MED GENET B, V147B, P1431, DOI 10.1002/ajmg.b.30704
Kollins SH, 2008, AM J MED GENET B, V147B, P1580, DOI 10.1002/ajmg.b.30876
Kooij JS, 2008, AM J MED GENET B, V147B, P201, DOI 10.1002/ajmg.b.30586
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
Lee B, 2009, J NEUROSCI, V29, P14734, DOI 10.1523/JNEUROSCI.3765-09.2009
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lott DC, 2006, AM J ADDICTION, V15, P327, DOI 10.1080/10550490600859868
Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x
Mattay VS, 2003, P NATL ACAD SCI USA, V100, P6186, DOI 10.1073/pnas.0931309100
McCracken JT, 2011, TXB AUTISM SPECTRUM, P159
McGough J, 2006, J AM ACAD CHILD PSY, V45, P1314, DOI 10.1097/01.chi.0000235083.40285.08
McGough JJ, 2009, J AM ACAD CHILD PSY, V48, P1155, DOI 10.1097/CHI.0b013e3181bc72e3
Misener VL, 2004, MOL PSYCHIATR, V9, P500, DOI 10.1038/sj.mp.4001440
Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
Nieminen-von Wendt TS, 2004, NEUROREPORT, V15, P757, DOI 10.1097/01.wnr.0000118868.31945.5b
Nurmi EL, 2009, KAPLAN SADOCKS COMPR
Oades RD, 2005, DEVELOPMENTAL SCI, V8, P122, DOI 10.1111/j.1467-7687.2005.00399.x
Polanczyk G, 2007, ARCH GEN PSYCHIAT, V64, P218, DOI 10.1001/archpsyc.64.2.218
Posey DJ, 2007, BIOL PSYCHIAT, V61, P538, DOI 10.1016/j.biopsych.2006.09.028
Purper-Ouakil D, 2008, ARCH PEDIATRIE, V15, P1834, DOI 10.1016/j.arcped.2008.09.026
Purper-Ouakil D, 2008, AM J MED GENET B, V147B, P1425, DOI 10.1002/ajmg.b.30809
QUINTANA H, 1995, J AUTISM DEV DISORD, V25, P283, DOI 10.1007/BF02179289
Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
Rosenbloom KR, 2012, NUCLEIC ACIDS RES, V40, pD912, DOI 10.1093/nar/gkr1012
Seeger G, 2001, NEUROSCI LETT, V313, P45, DOI 10.1016/S0304-3940(01)02253-4
SHAIKH S, 1993, LANCET, V341, P116, DOI 10.1016/0140-6736(93)92594-J
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Stein MA, 2005, NEUROPSYCHOPHARMACOL, V30, P1374, DOI 10.1038/sj.npp.1300718
Stein MA, 2008, CHILD ADOL PSYCH CL, V17, P475, DOI 10.1016/j.chc.2007.11.009
Tahir E, 2000, MOL PSYCHIATR, V5, P396, DOI 10.1038/sj.mp.4000744
van der Meulen EM, 2005, J CHILD PSYCHOL PSYC, V46, P1074
Volkow ND, 2005, BIOL PSYCHIAT, V57, P1410, DOI 10.1016/j.biopsych.2004.11.006
Ward LD, 2012, NUCLEIC ACIDS RES, V40, pD930, DOI 10.1093/nar/gkr917
Wendland JR, 2006, MOL PSYCHIATR, V11, P224, DOI 10.1038/sj.mp.4001789
WILLIAMS GV, 1995, NATURE, V376, P572, DOI 10.1038/376572a0
Zeni CP, 2007, AM J MED GENET B, V144B, P391, DOI 10.1002/ajmg.b.30474
NR 67
TC 3
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1470-269X
EI 1473-1150
J9 PHARMACOGENOMICS J
JI Pharmacogenomics J.
PD JUN
PY 2014
VL 14
IS 3
BP 295
EP 302
DI 10.1038/tpj.2013.23
PG 8
WC Genetics & Heredity; Pharmacology & Pharmacy
SC Genetics & Heredity; Pharmacology & Pharmacy
GA AI0SK
UT WOS:000336560000014
PM 23856854
ER
PT J
AU Du, L
Greer, RD
AF Du, Lin
Greer, R. Douglas
TI Validation of Adult Generalized Imitation Topographies and the Emergence
of Generalized Imitation in Young Children with Autism as a Function of
Mirror Training
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE Generalized imitation; Autism; Mirror training
ID HUMAN CORPUS-CALLOSUM; CONDITIONED REINFORCEMENT; SEXUAL DIMORPHISM;
GESTURES; INFANTS; PRESCHOOL
AB We tested 128 adults; male and female ages 19 to 56, for the emission of mirrored or non-mirrored responses in generalized imitation (GI). We found that the adults emitted both. Thus, the emission of non-mirrored responses was not part of the criterion for GI in Experiment 2, where we isolated the effects of using a mirror for training imitative responses on the emergence of GI by children with autism (six children, 3-4 years old). We used an experimental-control group design with a "nested" non-concurrent multiple probe design across participants in the experimental group. Test scores and developmental measures were used to match participants who were then assigned randomly to groups. The numbers of instructional trials were yoked between pairs controlling the amount of instruction. GI emerged for the individuals who received the mirror training, but not for those trained face-to-face. One possibility is that mirror training rotating different responses may result in a class of responding whereas, face-to-face training results in specific responses, which may explain why prior studies were unable to induce GI with typically developing young children. Moreover, given the findings herein, the correspondence between seeing and doing as conditioned reinforcement for GI remains a viable theory.
C1 [Du, Lin; Greer, R. Douglas] Columbia Univ, Teachers Coll, New York, NY 10027 USA.
[Du, Lin; Greer, R. Douglas] Columbia Univ, Grad Sch Arts & Sci, New York, NY USA.
RP Du, L (reprint author), Fred S Keller Sch, Yonkers, NY 10701 USA.
EM ld2238@exchange.tc.columbia.edu
CR Albers A. E., 1991, J BEHAV ED, V1, P337, DOI 10.1007/BF00947188
ALLEN LS, 1991, J NEUROSCI, V11, P933
Attermeier S. M., 1991, CAROLINA CURRICULUM
Baer D. M., 1985, THEORETICAL ISSUES B, P179
BAER DM, 1964, J EXP CHILD PSYCHOL, V1, P37, DOI 10.1016/0022-0965(64)90005-0
BAER DM, 1967, J EXP ANAL BEHAV, V10, P405, DOI 10.1901/jeab.1967.10-405
Bekkering H, 2000, Q J EXP PSYCHOL-A, V53, P153, DOI 10.1080/027249800390718
Bishop KM, 1997, NEUROSCI BIOBEHAV R, V21, P581, DOI 10.1016/S0149-7634(96)00049-8
Bzoch K., 1991, RECEPTIVE EEXPRESSIV
Catania A. C., 2007, LEARNING INTERIM
DELACOSTEUTAMSING C, 1982, SCIENCE, V216, P1431, DOI 10.1126/science.7089533
Dearborn K., 2006, J DANCE ED, V6, P109
DeWeerdt S., 2013, SIM FDN AUT RES IN N
Douglas Greer R., 2002, DESIGNING TEACHING S
Ehrenberg S., 2010, THEATRE DANCE PERFOR, V1, P172
Emurian HH, 2000, COMPUT HUM BEHAV, V16, P395, DOI 10.1016/S0747-5632(00)00019-4
Erjavec M, 2008, J EXP ANAL BEHAV, V89, P183, DOI 10.1901/jeab.2008.89-183
Erjavec M., 2002, THESIS U WALES BANGO
Erjavec M, 2009, J EXP ANAL BEHAV, V91, P355, DOI 10.1901/jeab.2009.91-355
Folio M. R., 2000, PEABODY DEV MOTOR SC
GEWIRTZ JL, 1968, PSYCHOL REV, V75, P374, DOI 10.1037/h0026378
Gleissner B, 2000, DEVELOPMENTAL SCI, V3, P405, DOI 10.1111/1467-7687.00135
Glover M. E., 1988, EARLY LAP EARLY LEAR
Greeri RD, 2008, J EXP ANAL BEHAV, V89, P15, DOI 10.1901/jeab.2008.89-15
Greer R. D., 2007, EUROPEAN J BEHAV ANA, V8, P119
Greer R Douglas, 2010, Anal Verbal Behav, V26, P73
Greer R. D., 2009, INT CURRICULUM INVEN
Greer R. D., 2008, VERBAL BEHAV ANAL IN
GREER RD, 1994, BEHAVIOR ANALYSIS IN EDUCATION, P161
Greer RD, 2008, REV MEX PSICOL, V25, P5
Greer RD, 2009, PSYCHOL REC, V59, P449
Hardan AY, 2009, PSYCHIAT RES-NEUROIM, V174, P57, DOI 10.1016/j.pscychresns.2009.03.005
HARRIS L. J., 1978, ASYMMETRICAL FUNCTIO, P405
Hayes S. C., 2001, RELATIONAL FRAME THE
HOLLOWAY RL, 1986, HUM NEUROBIOL, V5, P87
Horne PJ, 2007, J EXP ANAL BEHAV, V87, P63, DOI 10.1901/jeab.2007.11-06
HOURCADE JJ, 1988, EDUC TRAIN MENT RET, V23, P38
Keary CJ, 2009, J AUTISM DEV DISORD, V39, P834, DOI 10.1007/s10803-009-0689-4
Keohane D., 2009, DERIVED RELATIONAL R
Lerman DC, 2003, J APPL BEHAV ANAL, V36, P119, DOI 10.1901/jaba.2003.36-119
MELTZOFF AN, 1989, DEV PSYCHOL, V25, P954, DOI 10.1037/0012-1649.25.6.954
MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
Mitchell R. W., 1993, NEW IDEAS PSYCHOL, V11, P296
Mitchell R. W., 1992, PSYCHOL INQ, V3, P127, DOI 10.1207/s15327965pli0302_9
Moreno J., 2012, THESIS
OZONOFF S, 1995, J AUTISM DEV DISORD, V25, P415, DOI 10.1007/BF02179376
Poulson CL, 2002, J EXP CHILD PSYCHOL, V81, P341, DOI 10.1006/jecp.2002.2661
POULSON CL, 1988, J EXP CHILD PSYCHOL, V46, P324, DOI 10.1016/0022-0965(88)90064-1
POULSON CL, 1991, J EXP CHILD PSYCHOL, V51, P267, DOI 10.1016/0022-0965(91)90036-R
Rossetti L, 1990, ROSSETTI INFANT TODD
Rothstein M. B., 2010, THESIS
SHERMAN J, 1978, SEX RELATED COGNITIV
Shuster J. M., 1988, J APPL BEHAV ANAL, V21, P169
Singer-Dudek J, 2011, J APPL BEHAV ANAL, V44, P421, DOI 10.1901/jaba.2011.44-421
Sparrow SS, 2005, VINELAND ADAPTIVE BE
TERRACE HS, 1963, J EXP ANAL BEHAV, V6, P1, DOI 10.1901/jeab.1963.6-1
Tomasello M., 1999, CULTURAL ORIGINS HUM
TOUCHETTE PE, 1984, J APPL BEHAV ANAL, V17, P175, DOI 10.1901/jaba.1984.17-175
Voress J, 1998, DEV ASSESSMENT YOUNG
Wohlschlager A, 2003, PHILOS T R SOC B, V358, P501, DOI 10.1098/rstb.2002.1257
Zentall TR, 2006, ANIM COGN, V9, P335, DOI 10.1007/s10071-006-0039-2
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 62
TC 2
Z9 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD JUN
PY 2014
VL 64
IS 2
BP 161
EP 177
DI 10.1007/s40732-014-0050-y
PG 17
WC Psychology, Multidisciplinary
SC Psychology
GA AI2ZX
UT WOS:000336729000003
ER
PT J
AU Lanovaz, MJ
Rapp, JT
Long, ES
Richling, SM
Carroll, RA
AF Lanovaz, Marc J.
Rapp, John T.
Long, Ethan S.
Richling, Sarah M.
Carroll, Regina A.
TI Preliminary Effects of Conditioned Establishing Operations on Stereotypy
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE Autism; Automatic reinforcement; Establishing operation; Conditioned
motivating operation; Stereotypy
ID BEHAVIOR-ANALYSIS; MULTIPLE FORMS; INTERVENTION; STIMULATION; SKILLS
AB We repeatedly paired preferred stimuli with known establishing properties and poster boards (i.e., neutral stimuli) to examine whether these poster boards would acquire the effects of a conditioned establishing operation in five children with autism. Following pairing, the poster boards, which had been previously shown to be neutral, increased immediate or subsequent engagement in stereotypy for three of five participants. The results suggest that it is possible to condition establishing operations for stereotypy and that this process may occur inadvertently. We discuss the potential clinical implications of the results, as well as the need for future research to replicate our findings.
C1 [Lanovaz, Marc J.] Univ Montreal, Montreal, PQ H3C 3J7, Canada.
[Rapp, John T.] St Cloud State Univ, St Cloud, MN 56301 USA.
[Long, Ethan S.] Virginia Inst Autism, Charlottesville, VA 22903 USA.
[Richling, Sarah M.] Univ Nevada, Reno, NV 89557 USA.
[Carroll, Regina A.] W Virginia Univ, Morgantown, WV 26506 USA.
RP Lanovaz, MJ (reprint author), Univ Montreal, CP 6128,Succ Ctr Ville, Montreal, PQ H3C 3J7, Canada.
EM marc.lanovaz@umontreal.ca; jtrapp@stcloudstate.edu; elong@viaschool.org;
sarah.m.richling@gmail.com; racarroll@mail.wvu.edu
CR Adelinis JD, 1997, RES DEV DISABIL, V18, P383, DOI 10.1016/S0891-4222(97)00017-6
Carter SL, 2004, BEHAV INTERVENT, V19, P51, DOI 10.1002/bin.150
Critchfield TS, 2011, BEHAV ANALYST, V34, P3
Friman PC, 2000, J APPL BEHAV ANAL, V33, P507, DOI 10.1901/jaba.2000.33-507
Lang R, 2009, J APPL BEHAV ANAL, V42, P889, DOI 10.1901/jaba.2009.42-889
Lang R, 2010, BEHAV MODIF, V34, P267, DOI 10.1177/0145445510370713
Lanovaz M. J., 2010, EUROPEAN J BEHAV ANA, V11, P17
Laraway S, 2003, J APPL BEHAV ANAL, V36, P407, DOI 10.1901/jaba.2003.36-407
Lerman DC, 2003, J APPL BEHAV ANAL, V36, P415, DOI 10.1901/jaba.2003.36-415
McGill P, 1999, J APPL BEHAV ANAL, V32, P393, DOI 10.1901/jaba.1999.32-393
MICHAEL J, 1993, BEHAV ANALYST, V16, P191
Mudford OC, 2009, J APPL BEHAV ANAL, V42, P165, DOI 10.1901/jaba.2009.42-165
Piazza CC, 2000, J APPL BEHAV ANAL, V33, P13, DOI 10.1901/jaba.2000.33-13
Rapp JT, 2007, J APPL BEHAV ANAL, V40, P73, DOI 10.1901/jaba.2007.142-05
Rapp JT, 2013, BEHAV MODIF, V37, P543, DOI 10.1177/0145445512461650
Rapp JT, 2008, BEHAV INTERVENT, V23, P113, DOI 10.1002/bin.259
Rapp JT, 2004, J APPL BEHAV ANAL, V37, P481, DOI 10.1901/jaba.2004.37-481
Rapp JT, 2004, BEHAV INTERVENT, V19, P287, DOI 10.1002/bin.166
Rapp JT, 2005, BEHAV INTERVENT, V20, P255, DOI 10.1002/bin.196
Rosales R, 2007, J APPL BEHAV ANAL, V40, P105, DOI 10.1901/jaba.2007.117-05
Shillingsburg M. A., 2005, CHILD FAMILY BEHAV T, V26, P43, DOI 10.1300/J019v26n04_03
Van Camp CM, 2000, J APPL BEHAV ANAL, V33, P207, DOI 10.1901/jaba.2000.33-207
NR 22
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD JUN
PY 2014
VL 64
IS 2
BP 209
EP 216
DI 10.1007/s40732-014-0027-x
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA AI2ZX
UT WOS:000336729000007
ER
PT J
AU Moran, L
Stewart, I
McElwee, J
Ming, S
AF Moran, Laura
Stewart, Ian
McElwee, John
Ming, Siri
TI Relational Ability and Language Performance in Children With Autism
Spectrum Disorders and Typically Developing Children: A Further Test of
the TARPA Protocol
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE TARPA; Autism spectrum disorder; PLS-4; Language; Relational frame
theory
ID FRAME-THEORY; TRANSPOSITION; EQUIVALENCE; INFANT
AB The Training and Assessment of Relational Precursors and Abilities (TARPA) protocol was developed to assess the emergence of derived relational responding, which has been argued by relational frame theory (RFT) to be the key process underlying language. Previous research showed a correlation between the TARPA and the Vineland Adaptive Behavior Scales (VABS) in several children with autism spectrum disorder (ASD). The current study advanced this work by correlating a more comprehensive and systematic TARPA protocol with the Preschool Language Scale, Fourth Edition (PLS-4), a mainstream performance-based language assessment, in 10 additional children with ASD (Experiment 1) and 13 typically developing children (Experiment 2). This study also involved a hierarchical analysis of the TARPA. Results showed (a) a strong and significant correlation between the TARPA and PLS-4 full scale and subscales, and (b) evidence to support the hierarchical structure of the TARPA. The implications of these and other findings are discussed.
C1 [Moran, Laura; Stewart, Ian] Natl Univ Ireland Galway, Sch Psychol, Galway City, Ireland.
RP Stewart, I (reprint author), Natl Univ Ireland Galway, Sch Psychol, Galway City, Ireland.
EM lauramoran1984@gmail.com; ian.stewart@nuigalway.ie;
john.mcelwee@wilkes.edu; s.ming1@nuigalway.ie
CR Barnes-Holmes Y., 2004, INT J PSYCHOL PSYCHO, V4, P559
Barnes-Holmes Y., 2004, INT J PSYCHOL PSYCHO, V4, P531
Berens NM, 2007, J APPL BEHAV ANAL, V40, P45, DOI 10.1901/jaba.2007.7-06
Carpentier F, 2003, PSYCHOL REC, V53, P349
Casey L., 1977, REHABIL PSYCHOL, V24, P137
Dymond S, 2010, BEHAV ANALYST, V33, P97
Giurfa M, 2001, NATURE, V410, P930, DOI 10.1038/35073582
Greer R. D., 2008, VERBAL BEHAV ANAL IN
HARMON K, 1982, LEARN MOTIV, V13, P495, DOI 10.1016/0023-9690(82)90006-6
Hayes S. C., 2001, RELATIONAL FRAME THE
Kerr N., 1977, REHABIL PSYCHOL, V24, P95
Krus D. J., 1975, ORDERING THEORY METH
LIPKENS R, 1993, J EXP CHILD PSYCHOL, V56, P201, DOI 10.1006/jecp.1993.1032
Luciano C, 2007, J EXP ANAL BEHAV, V87, P349, DOI 10.1901/jeab.2007.08-06
Malott Richard W, 2003, Anal Verbal Behav, V19, P11
Marion Carole, 2003, Anal Verbal Behav, V19, P91
Martin G. L., 2000, J DEV DISABILITIES, V7, P10
McGee J. P., 2001, ED CHILDREN AUTISM
Moran L, 2010, J AUTISM DEV DISORD, V40, P1149, DOI [10.1007/s10803-010-0968-0, 10.1007/s10803-010-0961-7]
Murphy C, 2005, J APPL BEHAV ANAL, V38, P445, DOI 10.1901/jaba.2005.97-04
Murphy C, 2007, AUTISM RES ADV
Murphy C., 2007, NEW AUTISM RES DEV
REESE HW, 1961, CHILD DEV, V32, P311, DOI 10.1111/j.1467-8624.1961.tb05029.x
Rehfeldt R. A., 2009, DERIVED RELATIONAL R
Rehfeldt RA, 2007, PSYCHOL REC, V57, P23
Roche B, 1997, J EXP ANAL BEHAV, V67, P275, DOI 10.1901/jeab.1997.67-275
Sidman M., 1986, DEV BEHAV PHARM, V5
Stewart I, 2009, BEHAV ANALYST, V32, P309
Sundberg M. L., 2008, VB MAPP VERBAL BEHAV
WRIGHT AA, 1994, J EXP PSYCHOL ANIM B, V20, P108
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 31
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD JUN
PY 2014
VL 64
IS 2
BP 233
EP 251
DI 10.1007/s40732-014-0032-0
PG 19
WC Psychology, Multidisciplinary
SC Psychology
GA AI2ZX
UT WOS:000336729000009
ER
PT J
AU Mirzaa, GM
Millen, KJ
Barkovich, AJ
Dobyns, WB
Paciorkowski, AR
AF Mirzaa, Ghayda M.
Millen, Kathleen J.
Barkovich, A. James
Dobyns, William B.
Paciorkowski, Alex R.
TI The Developmental Brain Disorders Database (DBDB): A curated
neurogenetics knowledge base with clinical and research applications
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE developmental brain disorders; database; bioinformatics; levels of
evidence
ID DE-NOVO MUTATIONS; GENETIC CLASSIFICATION; CORTICAL DEVELOPMENT; DELAY;
MALFORMATIONS; SPECTRUM; AUTISM
AB The number of single genes associated with neurodevelopmental disorders has increased dramatically over the past decade. The identification of causative genes for these disorders is important to clinical outcome as it allows for accurate assessment of prognosis, genetic counseling, delineation of natural history, inclusion in clinical trials, and in some cases determines therapy. Clinicians face the challenge of correctly identifying neurodevelopmental phenotypes, recognizing syndromes, and prioritizing the best candidate genes for testing. However, there is no central repository of definitions for many phenotypes, leading to errors of diagnosis. Additionally, there is no system of levels of evidence linking genes to phenotypes, making it difficult for clinicians to know which genes are most strongly associated with a given condition. We have developed the Developmental Brain Disorders Database (DBDB: https://www.dbdb.urmc.rochester.edu/home), a publicly available, online-curated repository of genes, phenotypes, and syndromes associated with neurodevelopmental disorders. DBDB contains the first referenced ontology of developmental brain phenotypes, and uses a novel system of levels of evidence for gene-phenotype associations. It is intended to assist clinicians in arriving at the correct diagnosis, select the most appropriate genetic test for that phenotype, and improve the care of patients with developmental brain disorders. For researchers interested in the discovery of novel genes for developmental brain disorders, DBDB provides a well-curated source of important genes against which research sequencing results can be compared. Finally, DBDB allows novel observations about the landscape of the neurogenetics knowledge base. (c) 2014 Wiley Periodicals, Inc.
C1 [Mirzaa, Ghayda M.; Millen, Kathleen J.; Dobyns, William B.] Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA USA.
[Mirzaa, Ghayda M.; Millen, Kathleen J.; Dobyns, William B.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA.
[Barkovich, A. James] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA.
[Paciorkowski, Alex R.] Univ Rochester, Med Ctr, Ctr Neural Dev & Dis, Rochester, NY 14642 USA.
[Paciorkowski, Alex R.] Univ Rochester, Med Ctr, Dept Neurol Pediat & Biomed Genet, Rochester, NY 14642 USA.
RP Paciorkowski, AR (reprint author), Univ Rochester, Med Ctr, 610 Elmwood Ave, Rochester, NY 14642 USA.
EM alex_paciorkowski@urmc.rochester.edu
FU National Institute of Neurological Disorders and Stroke (NINDS) of the
National Institutes of Health [R01NS046616, R01NS050375, R01NS058721,
K08NS078054]
FX Grant sponsor: National Institute of Neurological Disorders and Stroke
(NINDS) of the National Institutes of Health; Grant numbers:
R01NS046616, R01NS050375, R01NS058721, K08NS078054.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Barkovich AJ, 2012, PEDIAT NEUROIMAGING
Barkovich AJ, 2005, NEUROLOGY, V65, P1873, DOI 10.1212/01.wnl.0000183747.05269.2d
Barkovich AJ, 2012, BRAIN, V135, P1348, DOI 10.1093/brain/aws019
Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Firth HV, 2005, OXFORD DESK REFERENC
Haynes R Brian, 2006, Evid Based Med, V11, P162
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
Krzywinski M, 2012, BRIEF BIOINFORM, V13, P627, DOI 10.1093/bib/bbr069
Makela NL, 2009, AM J MED GENET A, V149A, P2393, DOI 10.1002/ajmg.a.33050
Mefford HC, 2009, GENOME RES, V19, P1579, DOI 10.1101/gr.094987.109
Mirzaa GM, 2013, AM J MED GENET C, V163C, P122, DOI 10.1002/ajmg.c.31361
Moeschler JB, 2008, SEMIN PEDIATR NEUROL, V15, P2, DOI 10.1016/j.spen.2008.01.002
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Panayiotopoulos CP, 2010, CLINICAL GUIDE TO EPILEPTIC SYNDROMES AND THEIR TREATMENT, P1
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Shaffer LG, 2005, GENET MED, V7, P650, DOI 10.1097/01.gim.0000186545.83160.le
Shen J, 2010, NAT GENET, V42, P245, DOI 10.1038/ng.526
Shevell M, 2003, NEUROLOGY, V60, P367
Sulakhe D, 2014, NUCLEIC ACIDS RES, V42, pD1007, DOI 10.1093/nar/gkt1166
Teutsch SM, 2009, GENET MED, V11, P3, DOI 10.1097/GIM.0b013e318184137c
Wan JJ, 2012, NAT GENET, V44, P704, DOI 10.1038/ng.2254
Wilson BJ, 2006, FAM CANCER, V5, P55, DOI 10.1007/s10689-005-2576-2
Zhang B, 2011, LANCET ONCOL, V12, P477, DOI 10.1016/S1470-2045(11)70076-6
NR 26
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2014
VL 164
IS 6
BP 1503
EP 1511
DI 10.1002/ajmg.a.36517
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA AH2BV
UT WOS:000335926600019
PM 24700709
ER
PT J
AU Steiner, NJ
Frenette, E
Hynes, C
Pisarik, E
Tomasetti, K
Perrin, EC
Rene, K
AF Steiner, Naomi J.
Frenette, Elizabeth
Hynes, Caitlin
Pisarik, Elizabeth
Tomasetti, Kathryn
Perrin, Ellen C.
Rene, Kirsten
TI A Pilot Feasibility Study of Neurofeedback for Children with Autism
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Article
DE Biofeedback; Autism spectrum disorder; Neurofeedback
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RATING-SCALE; SPECTRUM
DISORDERS; CHILDHOOD AUTISM; YOUNG-CHILDREN; VALIDITY; RELIABILITY;
INTERVENTION
AB Neurofeedback (NFB) is an emerging treatment for children with autism spectrum disorder (ASD). This pilot study examined the feasibility of NFB for children with ASD. Ten children ages 7-12 with high functioning ASD and attention difficulties received a NFB attention training intervention. A standardized checklist captured feasibility, including focus during exercises and academic tasks, as well as off-task behaviors. Active behaviors and vocalizations were the most frequent off-task behaviors. Positive reinforcement and breaks including calm breathing exercises were the most common supports. Low motivation was associated with higher feasibility challenges, yet parental involvement and accommodations were helpful. This pilot study shows that it is feasible to conduct NFB sessions with children with high functioning autism and attention difficulties.
C1 [Steiner, Naomi J.; Frenette, Elizabeth; Hynes, Caitlin; Pisarik, Elizabeth; Tomasetti, Kathryn; Rene, Kirsten] Tufts Med Ctr, Ctr Mind Body Pediat Res, Boston, MA 02111 USA.
[Perrin, Ellen C.] Tufts Med Ctr, Boston, MA 02111 USA.
RP Steiner, NJ (reprint author), Tufts Med Ctr, Ctr Mind Body Pediat Res, 800 Washington St,Box 854, Boston, MA 02111 USA.
EM nsteiner@tuftsmedicalcenter.org; efrenette@tuftsmedicalcenter.org;
caitlin.hynes@tufts.edu; elizabeth.pisarik@tufts.edu;
ktomasetti@tuftsmedicalcenter.org; eperrin@tuftsmedicalcenter.org;
krene@tuftsmedicalcenter.org
CR Anderson SR, 1999, J ASSOC PERS SEVERE, V24, P162, DOI 10.2511/rpsd.24.3.162
Bain SK, 2010, J PSYCHOEDUC ASSESS, V28, P167, DOI 10.1177/0734282909348217
Coben R, 2010, APPL PSYCHOPHYS BIOF, V35, P83, DOI 10.1007/s10484-009-9117-y
Collett BR, 2003, J AM ACAD CHILD PSY, V42, P1015, DOI 10.1097/01.CHI.0000070245.24125.B6
Conners CK, 1997, J ABNORM CHILD PSYCH, V25, P487, DOI 10.1023/A:1022637815797
Conners CK, 1998, J ABNORM CHILD PSYCH, V26, P257, DOI 10.1023/A:1022602400621
Cooper H, 1996, REV EDUC RES, V66, P227, DOI 10.3102/00346543066003227
Goldstein S., 2011, ADHD REPORT, V19, P10
Harris SL, 2002, INFANT YOUNG CHILD, V14, P11
Helicor Inc., 2012, STRESS ER
Jarusiewicz B., 2002, J NEUROTHERAPY, V6, P39, DOI [10.1300/j184v06n04_05, DOI 10.1300/J184V06N04_05]
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kouijzer MEJ, 2009, RES AUTISM SPECT DIS, V3, P145, DOI 10.1016/j.rasd.2008.05.001
Kumar G, 2003, J PERS ASSESS, V80, P252, DOI 10.1207/S15327752JPA8003_04
Langworthy-Lam KS, 2002, J CHILD ADOL PSYCHOP, V12, P311, DOI 10.1089/104454602762599853
Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
Marcus L. M., 2005, HDB AUTISM PERVASIVE, P1055
National Research Council, 2001, 3 FAM ROL ED CHILDR, P32
Owens EB, 2003, J CONSULT CLIN PSYCH, V71, P540, DOI 10.1037/0022-006X.71.3.540
Palmen A, 2012, RES AUTISM SPECT DIS, V6, P602, DOI 10.1016/j.rasd.2011.10.001
[潘学霞 PAN XueXia], 2007, [中国当代儿科杂志, Chinese Journal of Contemporary Pediatrics], V9, P210
Pineda JA, 2008, RES AUTISM SPECT DIS, V2, P557, DOI 10.1016/j.rasd.2007.12.003
Russell PSS, 2010, WORLD J PEDIATR, V6, P141, DOI 10.1007/s12519-010-0029-y
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Sichel A., 1995, J NEUROTHERAPY, V1, P60, DOI DOI 10.1300/J184V01N01_08
Steiner NJ, 2011, CLIN PEDIATR, V50, P615, DOI 10.1177/0009922810397887
Thompson L, 2010, APPL PSYCHOPHYS BIOF, V35, P63, DOI 10.1007/s10484-009-9120-3
Unique Logic and Technology, 2011, PLAY ATT
Wigal Sharon B, 2006, J Atten Disord, V10, P92, DOI 10.1177/1087054705286049
Wilens TE, 2008, J AM ACAD CHILD PSY, V47, P700, DOI 10.1097/CHI.0b013e31816bffdf
NR 30
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2014
VL 39
IS 2
BP 99
EP 107
DI 10.1007/s10484-014-9241-1
PG 9
WC Psychology, Clinical
SC Psychology
GA AH8KT
UT WOS:000336387400003
PM 24737038
ER
PT J
AU Pascalis, O
Loevenbruck, H
Quinn, PC
Kandel, S
Tanaka, JW
Lee, K
AF Pascalis, Olivier
Loevenbruck, Helene
Quinn, Paul C.
Kandel, Sonia
Tanaka, James W.
Lee, Kang
TI On the Links Among Face Processing, Language Processing, and Narrowing
During Development
SO CHILD DEVELOPMENT PERSPECTIVES
LA English
DT Article
DE narrowing; face; speech
ID SPEECH-PERCEPTION; TALKING FACES; INFANTS; EVOLUTION; VOICE;
DISCRIMINATION; RECOGNITION; BEHAVIOR; EMOTION; AUTISM
AB From the beginning of life, face and language processing are crucial for establishing social communication. Studies on the development of systems for processing faces and language have yielded such similarities as perceptual narrowing across both domains. In this article, we review several functions of human communication, and then describe how the tools used to accomplish those functions are modified by perceptual narrowing. We conclude that narrowing is common to all forms of social communication. We argue that during evolution, social communication engaged different perceptual and cognitive systemsface, facial expression, gesture, vocalization, sound, and oral languagethat emerged at different times. These systems are interactive and linked to some extent. In this framework, narrowing can be viewed as a way infants adapt to their native social group.
C1 [Pascalis, Olivier; Loevenbruck, Helene; Kandel, Sonia] Univ Grenoble Alpes, CNRS, LPNC UMR5105, F-38040 Grenoble 9, France.
[Loevenbruck, Helene] CNRS, Grenoble Images Parole Signal Automat, UMR5216, F-75700 Paris, France.
[Quinn, Paul C.] Univ Delaware, Dept Psychol, Newark, DE 19716 USA.
[Tanaka, James W.] Univ Victoria, Dept Psychol, Victoria, BC V8W 2Y2, Canada.
[Lee, Kang] Univ Toronto, Inst Child Study, Toronto, ON M5S 1A1, Canada.
RP Pascalis, O (reprint author), Univ Grenoble Alpes, Lab Psychol & NeuroCognit, BP 47, F-38040 Grenoble 9, France.
EM olivier.pascalis@upmf-grenoble.fr
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
Arnold K, 2008, CURR BIOL, V18, pR202, DOI 10.1016/j.cub.2008.01.040
BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
Belin P, 2011, BRIT J PSYCHOL, V102, P711, DOI 10.1111/j.2044-8295.2011.02041.x
Brown S., 2003, B PSYCHOL ARTS, V4, P15
Buccino G, 2001, EUR J NEUROSCI, V13, P400, DOI 10.1046/j.1460-9568.2001.01385.x
Chomsky N., 1965, ASPECTS THEORY SYNTA
Corballis MC, 2003, BEHAV BRAIN SCI, V26, P199, DOI 10.1017/S0140525X03000062
Coulon M, 2011, INT J BEHAV DEV, V35, P282, DOI 10.1177/0165025410396765
Demonet JF, 2005, PHYSIOL REV, V85, P49, DOI 10.1152/physrev.00049.2003
Diessel H, 2000, COGN LINGUIST, V11, P131
EIMAS PD, 1971, SCIENCE, V171, P303, DOI 10.1126/science.171.3968.303
Fitch WT, 2006, COGNITION, V100, P173, DOI 10.1016/j.cognition.2005.11.009
Fort M, 2013, LANG COGNITIVE PROC, V28, P1207, DOI 10.1080/01690965.2012.701758
Hannon EE, 2005, P NATL ACAD SCI USA, V102, P12639, DOI 10.1073/pnas.0504254102
Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
Hayden A, 2012, INFANCY, V17, P578, DOI 10.1111/j.1532-7078.2011.00098.x
Johnson EK, 2011, DEVELOPMENTAL SCI, V14, P1002, DOI 10.1111/j.1467-7687.2011.01052.x
BENOI C, 1994, J SPEECH HEAR RES, V37, P1195
Kita S., 2003, POINTING LANGUAGE CU
Kubicek C, 2013, INT J BEHAV DEV, V37, P106, DOI 10.1177/0165025412473016
Lee K., 2011, OXFORD HDB FACE PERC, P753
Lewkowicz DJ, 2012, P NATL ACAD SCI USA, V109, P1431, DOI 10.1073/pnas.1114783109
Lewkowicz DJ, 2009, TRENDS COGN SCI, V13, P470, DOI 10.1016/j.tics.2009.08.004
LOEvenbruck H., 2009, SOME ASPECTS SPEECH, P211
MacNeilage PF, 1998, BEHAV BRAIN SCI, V21, P499
Menard L., 2006, SPEECH PRODUCTION MO, P227
Nelson CA, 2001, INFANT CHILD DEV, V10, P3, DOI 10.1002/icd.239
Palmer SB, 2012, CHILD DEV, V83, P543, DOI 10.1111/j.1467-8624.2011.01715.x
Pons F, 2009, P NATL ACAD SCI USA, V106, P10598, DOI 10.1073/pnas.0904134106
Quinn PC, 2011, EMOT REV, V3, P197, DOI 10.1177/1754073910387941
Sai FZ, 2005, INFANT CHILD DEV, V14, P29, DOI 10.1002/icd.376
Scott LS, 2007, CURR DIR PSYCHOL SCI, V16, P197, DOI 10.1111/j.1467-8721.2007.00503.x
Trainor LJ, 2012, ANN NY ACAD SCI, V1252, P129, DOI 10.1111/j.1749-6632.2012.06462.x
TREHUB SE, 1973, DEV PSYCHOL, V9, P91, DOI 10.1037/h0034999
Vihman M. M., 1996, PHONOLOGICAL DEV ORI
Vogel M, 2012, DEVELOPMENTAL SCI, V15, P359, DOI 10.1111/j.1467-7687.2012.01138.x
Weikum WM, 2007, SCIENCE, V316, P1159, DOI 10.1126/science.1137686
Werker JF, 1999, ANNU REV PSYCHOL, V50, P509, DOI 10.1146/annurev.psych.50.1.509
NR 39
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1750-8592
EI 1750-8606
J9 CHILD DEV PERSPECT
JI Child Develop. Perspect.
PD JUN
PY 2014
VL 8
IS 2
BP 65
EP 70
DI 10.1111/cdep.12064
PG 6
WC Psychology, Developmental
SC Psychology
GA AH6ZU
UT WOS:000336282300002
ER
PT J
AU Treur, J
AF Treur, Jan
TI Displaying and Regulating Different Social Response Patterns: A
Computational Agent Model
SO COGNITIVE COMPUTATION
LA English
DT Article
DE Social response; ASD; Regulation; Computational agent model
ID AUTISM SPECTRUM DISORDERS; MIRROR NEURON SYSTEM; EMOTION REGULATION;
FRONTAL-CORTEX; COMMUNICATION; CONSEQUENCES; IMITATION; GAZE;
DYSFUNCTION; EXPRESSION
AB Differences in social responses of individuals can often be related to differences in functioning of certain neurological mechanisms. This paper presents a computational agent model capable of showing different types of social response patterns based on such mechanisms, adopted from theories on mirror neuron systems, emotion integration, emotion regulation, and empathy. The presented agent model provides a basis for humanlike social response patterns of virtual agents in the context of simulation-based training (e.g. for training of physicians or therapists), gaming, or for agent-based generation of virtual stories.
C1 Vrije Univ Amsterdam, Agent Syst Res Grp, NL-1081 HV Amsterdam, Netherlands.
RP Treur, J (reprint author), Vrije Univ Amsterdam, Agent Syst Res Grp, Boelelaan 1081, NL-1081 HV Amsterdam, Netherlands.
EM treur@cs.vu.nl
CR Ashby W. R, 1952, DESIGN BRAIN
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Barringer H., 1996, IMPERATIVE FUTURE PR
Bates J., 1994, LNCS, V830, P55
BEER RD, 1995, ADAPT BEHAV, V3, P469, DOI 10.1177/105971239500300405
Bickmore T., 2004, P ACM SIGCHI C HUM F, P1489
Bickmore TW, 2010, IEEE T AFFECT COMPUT, V1, P60, DOI 10.1109/T-AFFC.2010.4
Bonvicini KA, 2009, PATIENT EDUC COUNS, V75, P3, DOI 10.1016/j.pec.2008.09.007
Bosse T, 2012, COGN SYST RES, V13, P39, DOI 10.1016/j.cogsys.2010.10.003
Bosse T, 2007, INT J ARTIF INTELL T, V16, P435, DOI 10.1142/S0218213007003357
Bosse T, 2010, COGN SYST RES, V11, P211, DOI 10.1016/j.cogsys.2009.10.001
Boukricha Hana, 2011, KI-Kunstliche Intelligenz, V25, DOI 10.1007/s13218-011-0109-8
Brass M, 2009, SOCIAL COGNITION DEV, P52
Cacioppo J.T., 2005, SOCIAL NEUROSCIENCE
Cacioppo J. T., 2006, SOCIAL NEUROSCIENCE
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794
Damasio A., 2003, LOOKING SPINOZA
Damasio Antonio, 1999, FEELING WHAT HAPPENS
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
De Vignemont F., 2006, TRENDS COGN SCI, V10, P437
Decety J, 2010, HDB SOCIAL NEUROSCIE
Fisher M, 2005, AUTON AGENT MULTI-AG, V10, P41, DOI 10.1007/s10458-004-3140-4
FORBUS KD, 1984, ARTIF INTELL, V24, P85, DOI 10.1016/0004-3702(84)90038-9
Fried I, 2011, NEURON, V69, P548, DOI 10.1016/j.neuron.2010.11.045
Frith U., 2003, AUTISM EXPLAINING EN
Galton A, 2006, SYNTHESE, V150, P415, DOI 10.1007/s11229-005-5516-7
Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006
Goldin PR, 2008, BIOL PSYCHIAT, V63, P577, DOI 10.1016/j.biopsych.2007.05.031
Gratch J, 2009, COGN SYST RES, V10, P1, DOI 10.1016/j.cogsys.2008.06.001
Greenland S, 2002, INT J EPIDEMIOL, V31, P1030, DOI 10.1093/ije/31.5.1030
Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
Grezes J., 2009, SOCIAL COGNITION DEV, P67
Gross J. J., 2007, HDB EMOTION REGULATI
Gross JJ, 2001, CURR DIR PSYCHOL SCI, V10, P214, DOI 10.1111/1467-8721.00152
Gross JJ, 1998, J PERS SOC PSYCHOL, V74, P224, DOI 10.1037//0022-3514.74.1.224
Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
Harmon-Jones E., 2007, SOCIAL NEUROSCIENCE
Hendriks M, 2010, LECT NOTES ARTIF INT, V6421, P330, DOI 10.1007/978-3-642-16693-8_35
Hojat M., 2007, EMPATHY PATIENT CARE
Hojat Mohammadreza, 2009, J Health Hum Serv Adm, V31, P412
HOPFIELD JJ, 1984, P NATL ACAD SCI-BIOL, V81, P3088, DOI 10.1073/pnas.81.10.3088
HOPFIELD JJ, 1982, P NATL ACAD SCI-BIOL, V79, P2554, DOI 10.1073/pnas.79.8.2554
HUTT C, 1964, NATURE, V204, P908, DOI 10.1038/204908a0
Iacoboni M, 2008, BEHAV BRAIN SCI, V31, P30, DOI 10.1017/S0140525X07003214
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iacoboni Marco, 2008, MIRRORING PEOPLE NEW
Keysers C., 2010, CURR BIOL, V20, P253
Kirchner JC, 2011, J AUTISM DEV DISORD, V41, P158, DOI 10.1007/s10803-010-1032-9
Klein J, 2002, INTERACT COMPUT, V14, P119
Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Leiberg S., 2009, COGNITIVE NEUROSCIEN, P973
Leite I, 2012, LNCS, P135
McQuiggan S, 2008, P 7 INT JOINT C AUT, P167
Mukamel R, 2010, CURR BIOL, V20, P750, DOI 10.1016/j.cub.2010.02.045
Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
Ochs Magalie, 2008, P 7 INT JOINT C AUT, V1, P89
Paiva A., 2011, INT J VIRTUAL REALIT, V10, P65
Pessoa L, 2008, NAT REV NEUROSCI, V9, P148, DOI 10.1038/nrn2317
Phelps EA, 2006, ANNU REV PSYCHOL, V57, P27, DOI 10.1146/annurev.psych.56.091103.070234
Pineda J.A., 2009, MIRROR NEURON SYSTEM
Richer J, 2001, AUTISM SEARCH COHERE
Rodrigues SH, 2009, 3 INT C AFF COMP INT
Sinigaglia C., 2008, MIRRORS BRAIN OUR MI
Smith A, 2009, PSYCHOL REC, V59, P489
Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027
Striano T., 2009, SOCIAL COGNITION DEV, P237
Suchman AL, 1997, JAMA-J AM MED ASSOC, V277, P678, DOI 10.1001/jama.277.8.678
Tinbergen EA, 1972, ADV ETHOLOGY, V10
Treur J, 2011, LECT NOTES COMPUT SC, V7062, P9, DOI 10.1007/978-3-642-24955-6_2
Treur J., 2011, P 22 INT JOINT C ART, P1743
Tulsky JA, 2011, ANN INTERN MED, V155, P593, DOI 10.7326/0003-4819-155-9-201111010-00007
van der Laan Y, 2011, LECT NOTES ARTIF INT, V6703, P306
van Gelder Timothy, 1995, MIND MOTION EXPLORAT
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
Yang HW, 2008, KNOWL ENG REV, V23, P321, DOI 10.1017/S0269888908000027
Zimmermann C, 2011, PATIENT EDUC COUNS, V82, P141, DOI 10.1016/j.pec.2010.03.017
NR 78
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1866-9956
EI 1866-9964
J9 COGN COMPUT
JI Cogn. Comput.
PD JUN
PY 2014
VL 6
IS 2
BP 182
EP 199
DI 10.1007/s12559-013-9233-0
PG 18
WC Computer Science, Artificial Intelligence; Neurosciences
SC Computer Science; Neurosciences & Neurology
GA AH7LD
UT WOS:000336313700005
ER
PT J
AU Ganz, JB
Rispoli, MJ
Mason, RA
Hong, ER
AF Ganz, Jennifer B.
Rispoli, Mandy J.
Mason, Rose Ann
Hong, Ee Rea
TI Moderation of effects of AAC based on setting and types of aided AAC on
outcome variables: An aggregate study of single-case research with
individuals with ASD
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE AAC; augmentative and alternative communication; meta-analysis; autism;
setting; PECS; SGD
ID EXCHANGE COMMUNICATION-SYSTEM; AUTISM SPECTRUM DISORDERS;
SPEECH-GENERATING DEVICES; DEVELOPMENTAL-DISABILITIES; ALTERNATIVE
COMMUNICATION; FUNCTIONAL COMMUNICATION; SUBJECT RESEARCH;
YOUNG-CHILDREN; PARTICIPANT CHARACTERISTICS; QUANTITATIVE SYNTHESIS
AB Objective: The purpose of this meta-analysis was to evaluate the potential moderating effects of intervention setting and type of aided augmentative and alternative communication (AAC) on outcome variables for students with autism spectrum disorders.
Methods: Improvement rate difference, an effect size measure, was used to calculate aggregate effects across 35 single-case research studies.
Results: Results indicated that the largest effects for aided AAC were observed in general education settings. With respect to communication outcomes, both speech generating devices (SGDs) and the Picture Exchange Communication System (PECS) were associated with larger effects than other picture-based systems. With respect to challenging behaviour outcomes, SGDs produced larger effects than PECS.
Conclusion: This aggregate study highlights the importance of considering intervention setting, choice of AAC system and target outcomes when designing and planning an aided AAC intervention.
C1 [Ganz, Jennifer B.; Rispoli, Mandy J.; Mason, Rose Ann; Hong, Ee Rea] Texas A&M Univ, Dept Educ Psychol, College Stn, TX 77843 USA.
[Mason, Rose Ann] Univ Kansas, Juniper Gardens Childrens Project, Kansas City, KS 66101 USA.
RP Ganz, JB (reprint author), Texas A&M Univ, Dept Educ Psychol, 4225 TAMU, College Stn, TX 77843 USA.
EM jeniganz@tamu.edu
CR ALLISON DB, 1993, BEHAV RES THER, V31, P621, DOI 10.1016/0005-7967(93)90115-B
American Psychiatric Association (APA), 2000, DIAGNOSTIC AND STATI
Angermeier K, 2010, J DEV PHYS DISABIL, V22, P197, DOI 10.1007/s10882-010-9193-1
Ben Chaabane Delia B, 2009, J Appl Behav Anal, V42, P671, DOI 10.1901/jaba.2009.42-671
Borenstein M., 2009, INTRODUCTION TO META
Buckley SD, 2005, RES DEV DISABIL, V26, P77, DOI 10.1016/j.ridd.2004.07.004
Cannella-Malone H, 2010, J DEV PHYS DISABIL, V22, P149, DOI 10.1007/s10882-009-9174-4
Carre AJM, 2009, BEHAV CHANGE, V26, P54
Charlop-Christy MH, 2010, JOURNAL OF APPLIED B, V35, P213
Choi H, 2010, RES DEV DISABIL, V31, P560, DOI 10.1016/j.ridd.2009.12.006
Drager KDR, 2006, AM J SPEECH-LANG PAT, V15, P112, DOI 10.1044/1058-0360(2006/012)
Flippin M, 2010, AM J SPEECH-LANG PAT, V19, P178, DOI 10.1044/1058-0360(2010/09-0022)
Franco JH, 2009, FOCUS AUTISM DEV DIS, V24, P146, DOI 10.1177/1088357609338380
Frost L., 2011, PICTURES WORTH PECS
Ganz JB, 2012, J AUTISM DEV DISORD, V42, P60, DOI 10.1007/s10803-011-1212-2
Ganz JB, 2004, J AUTISM DEV DISORD, V34, P395, DOI 10.1023/B:JADD.0000037416.59095.d7
Ganz JB, 2011, RES AUTISM SPECT DIS, V5, P1500, DOI 10.1016/j.rasd.2011.02.011
Ganz JB, 2012, RES DEV DISABIL, V33, P406, DOI 10.1016/j.ridd.2011.09.023
Ganz JB, 2012, EDUC TRAIN AUTISM DE, V47, P176
Ganz JB, 2008, RES AUTISM SPECT DIS, V2, P157, DOI 10.1016/j.rasd.2007.04.005
Hart SL, 2010, REM SPEC EDUC, V31, P476, DOI 10.1177/0741932509338354
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Johnston S., 2003, AUGMENTATIVE ALTERNA, V19, P86, DOI 10.1080/0743461031000112016
Johnston SS, 2009, AUGMENT ALTERN COMM, V25, P136, DOI 10.1080/07434610902921516
Jurgens A, 2009, BEHAV CHANGE, V26, P66
Kagohara D., 2012, RES DEV DISABIL, V34, P147
Keen D, 2001, J AUTISM DEV DISORD, V31, P385, DOI 10.1023/A:1010612618969
Kratowill TR, 2002, SCHOOL PSYCHOL QUART, V17, P341, DOI 10.1521/scpq.17.4.341.20872
Kravits TR, 2002, J AUTISM DEV DISORD, V32, P225, DOI 10.1023/A:1015457931788
Lund SK, 2008, J AUTISM DEV DISORD, V38, P719, DOI 10.1007/s10803-007-0439-4
Marckel JM, 2006, J APPL BEHAV ANAL, V39, P109, DOI 10.1901/jaba.2006.131-04
Millar DC, 2006, J SPEECH LANG HEAR R, V49, P248, DOI 10.1044/1092-4388(2006/021)
Mirenda P., 2001, FOCUS AUTISM OTHER D, V16, P141, DOI DOI 10.1177/108835760101600302
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
Mirenda P, 2009, AUTISM SPECTRUM DISO, P3
Nunes D., 2007, INT J DISABIL DEV ED, V4, P177, DOI [10.1080/10349120701330495, DOI 10.1080/10349120701330495]
Odom SL, 2009, TOP EARLY CHILD SPEC, V29, P53, DOI 10.1177/0271121408329171
Ohtake Y, 2010, EDUC TRAIN AUTISM DE, V45, P410
Olive ML, 2008, RES AUTISM SPECT DIS, V2, P223, DOI 10.1016/j.rasd.2007.06.002
Olive ML, 2007, J AUTISM DEV DISORD, V37, P1505, DOI 10.1007/s10803-006-0243-6
Ostryn C, 2008, RES PRACT PERS SEV D, V33, P13
Park JH, 2011, TOP EARLY CHILD SPEC, V31, P37, DOI 10.1177/0271121410393750
Parker RI, 2009, EXCEPT CHILDREN, V75, P135
Preston D, 2009, J AUTISM DEV DISORD, V39, P1471, DOI 10.1007/s10803-009-0763-y
Reichle J., 2005, ED PSYCHOL, V25, P275, DOI 10.1080/0144341042000301201
Rispoli M, 2012, DEVELOPMENTAL NEUROR, V13, P276
Schepis MM, 1998, J APPL BEHAV ANAL, V31, P561, DOI 10.1901/jaba.1998.31-561
Schlosser R. W., 2003, AUGMENTATIVE ALTERNA, V19, P5, DOI 10.1080/0743461032000056450
Schlosser RW, 2007, RES AUTISM SPECT DIS, V1, P139, DOI 10.1016/j.rasd.2006.10.001
Schlosser RW, 1998, J AUTISM DEV DISORD, V28, P309, DOI 10.1023/A:1026060619378
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
Schlosser RW, 2004, J SPEECH LANG HEAR R, V47, P848, DOI [10.1044/1092-4388(2004/063), 10.4044/1092-4388(2004/063)]
Scruggs TE, 1998, BEHAV MODIF, V22, P221, DOI 10.1177/01454455980223001
Sigafoos J, 2004, RES DEV DISABIL, V25, P371, DOI 10.1016/j.ridd.2003.07.002
Sigafoos J, 2004, J AUTISM DEV DISORD, V34, P411, DOI 10.1023/B:JADD.0000037417.04356.9c
Sulzer-Azaroff B, 2009, FOCUS AUTISM DEV DIS, V24, P89, DOI 10.1177/1088357609332743
Thompson RH, 1998, J APPL BEHAV ANAL, V31, P103, DOI 10.1901/jaba.1998.31-103
Tien KC, 2008, EDUC TRAIN DEV DISAB, V43, P61
Tincani M, 2006, EDUC TRAIN DEV DISAB, V41, P177
Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
Tincani M, 2011, REM SPEC EDUC, V32, P458, DOI 10.1177/0741932510362494
Trembath D, 2009, J INTELLECT DEV DIS, V34, P173, DOI 10.1080/13668250902845210
van der Meer L, 2012, RES DEV DISABIL, V33, P1658, DOI 10.1016/j.ridd.2012.04.004
van der Meer LAJ, 2010, DEV NEUROREHABIL, V13, P294, DOI 10.3109/17518421003671494
Vittimberga G. L, 2001, J POSIT BEHAV INTERV, V3, P194, DOI 10.1177/109830070100300401
WHITE OR, 1987, REM SPEC EDUC, V8, P34
YAMAMOTO J., 2006, JAPANESE J SPECIAL E, V43, P485
NR 67
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD JUN
PY 2014
VL 17
IS 3
BP 184
EP 192
DI 10.3109/17518423.2012.748097
PG 9
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA AH3QY
UT WOS:000336041300005
PM 24102440
ER
PT J
AU Waltes, R
Duketis, E
Knapp, M
Anney, RJL
Huguet, G
Schlitt, S
Jarczok, TA
Sachse, M
Kampfer, LM
Kleinbock, T
Poustka, F
Bolte, S
Schmotzer, G
Voran, A
Huy, E
Meyer, J
Bourgeron, T
Klauck, SM
Freitag, CM
Chiocchetti, AG
AF Waltes, Regina
Duketis, Eftichia
Knapp, Michael
Anney, Richard J. L.
Huguet, Guillaume
Schlitt, Sabine
Jarczok, Tomasz A.
Sachse, Michael
Kaempfer, Laura M.
Kleinboeck, Tina
Poustka, Fritz
Boelte, Sven
Schmoetzer, Gabriele
Voran, Anette
Huy, Ellen
Meyer, Jobst
Bourgeron, Thomas
Klauck, Sabine M.
Freitag, Christine M.
Chiocchetti, Andreas G.
TI Common variants in genes of the postsynaptic FMRP signalling pathway are
risk factors for autism spectrum disorders
SO HUMAN GENETICS
LA English
DT Article
ID FRAGILE-X-SYNDROME; PROTEIN-KINASE-IV; METABOTROPIC GLUTAMATE RECEPTORS;
MENTAL-RETARDATION PROTEIN; GENOME-WIDE ASSOCIATION; DIAGNOSTIC
INTERVIEW; MESSENGER-RNA; GERMAN FORM; EXPRESSION; TRANSLATION
AB Autism spectrum disorders (ASD) are heterogeneous disorders with a high heritability and complex genetic architecture. Due to the central role of the fragile X mental retardation gene 1 protein (FMRP) pathway in ASD we investigated common functional variants of ASD risk genes regulating FMRP. We genotyped ten SNPs in two German patient sets (N = 192 and N = 254 families, respectively) and report association for rs7170637 (CYFIP1; set 1 and combined sets), rs6923492 (GRM1; combined sets), and rs25925 (CAMK4; combined sets). An additional risk score based on variants with an odds ratio (OR) > 1.25 in set 1 and weighted by their respective log transmitted/untransmitted ratio revealed a significant effect (OR 1.30, 95 % CI 1.11-1.53; P = 0.0013) in the combined German sample. A subsequent meta-analysis including the two German samples, the "Strict/European" ASD subsample of the Autism Genome Project (1,466 families) and a French case/control (541/366) cohort showed again association of rs7170637-A (OR 0.85, 95 % CI 0.75-0.96; P = 0.007) and rs25925-G (OR 1.31, 95 % CI 1.04-1.64; P = 0.021) with ASD. Functional analyses revealed that these minor alleles predicted to alter splicing factor binding sites significantly increase levels of an alternative mRNA isoform of the respective gene while keeping the overall expression of the gene constant. These findings underpin the role of ASD candidate genes in postsynaptic FMRP regulation suggesting that an imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates ASD risk. Both gene products are related to neuronal regulation of synaptic plasticity, a pathomechanism underlying ASD and may thus present future targets for pharmacological therapies in ASD.
C1 [Waltes, Regina; Duketis, Eftichia; Schlitt, Sabine; Jarczok, Tomasz A.; Sachse, Michael; Kaempfer, Laura M.; Kleinboeck, Tina; Poustka, Fritz; Boelte, Sven; Schmoetzer, Gabriele; Freitag, Christine M.; Chiocchetti, Andreas G.] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
[Knapp, Michael] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-53105 Bonn, Germany.
[Anney, Richard J. L.] Trinity Coll Dublin, Dept Psychiat, Sch Med, Autism Genet Grp, Dublin 8, Ireland.
[Huguet, Guillaume; Bourgeron, Thomas] Inst Pasteur, F-75015 Paris, France.
[Huguet, Guillaume; Bourgeron, Thomas] Univ Paris Diderot Paris 7, Fdn FondaMental, CNRS, URA 2182, F-75015 Paris, France.
[Boelte, Sven] Karolinska Inst, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, S-11330 Stockholm, Sweden.
[Boelte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, S-11895 Stockholm, Sweden.
[Voran, Anette; Huy, Ellen] Saarland Univ Hosp, Dept Child & Adolescent Psychiat, D-66421 Homburg, Germany.
[Meyer, Jobst] Univ Trier, Inst Psychobiol, Dept Neurobehav Genet, D-54290 Trier, Germany.
[Klauck, Sabine M.] German Canc Res Ctr, Div Mol Genome Anal, D-69120 Heidelberg, Germany.
RP Chiocchetti, AG (reprint author), Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, Deutschordenstr 50, D-60528 Frankfurt, Germany.
EM andreas.chiocchetti@kgu.de
FU Saarland University [T6 03 10 00-45]; Deutsche Forschungsgemeinschaft
DFG [Po 255/17-4]; European Commission; German Bundesministerium fur
Bildung und Forschung BMBF (ERA-NET NEURON project: EUHFAUTISM)
[EUHFAUTISM-01EW1105]; Landes-Offensive zur Entwicklung
wissenschaftlich-okonomischer Exzellenz (LOEWE): Neuronal Coordination
Research Focus Frankfurt (NeFF)
FX We thank all patients and their families for taking part in this study.
In addition, we thoroughly thank Veronika Delcheva, Silvia Lindlar,
Marnie Kopp, Hiacynta Jelen and Cornelia Wirth for excellent technical
assistance and Heiko Zerlaut and Rusico Weber for database management.
This work was supported by the Saarland University (T6 03 10 00-45 to C.
M. F.); the Deutsche Forschungsgemeinschaft DFG (Po 255/17-4 to F. P.);
the European Commission and the German Bundesministerium fur Bildung und
Forschung BMBF (ERA-NET NEURON project: EUHFAUTISM) (EUHFAUTISM-01EW1105
to C. M. F.); and the Landes-Offensive zur Entwicklung
wissenschaftlich-okonomischer Exzellenz (LOEWE): Neuronal Coordination
Research Focus Frankfurt (NeFF). Furthermore, we gratefully acknowledge
the families participating in the Autism Genome Project (AGP) and the
main funders: Autism Speaks (USA), the Health Research Board (HRB;
Ireland), the Medical Research Council (MRC; UK), Genome Canada/Ontario
Genomics Institute and the Hilibrand Foundation (USA).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Bagni C, 2012, J CLIN INVEST, V122, P4314, DOI 10.1172/JCI63141
Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159
Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bolte S, 2004, Z KINDER JUG-PSYCH, V32, P45, DOI 10.1024/1422-4917.32.1.45
Bozdagi O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042422
Cartegni L, 2003, NUCLEIC ACIDS RES, V31, P3568, DOI 10.1093/nar/gkg616
Cordell HJ, 2004, GENET EPIDEMIOL, V26, P186, DOI 10.1002/gepi.10306
Curatolo P, 2010, J CHILD NEUROL, V25, P873, DOI 10.1177/0883073810361789
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
De Rubeis S, 2011, J NEURODEV DISORD, V3, P257, DOI 10.1007/s11689-011-9087-2
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
de Vries PJ, 2010, NEUROTHERAPEUTICS, V7, P275, DOI 10.1016/j.nurt.2010.05.001
Dixon AL, 2007, NAT GENET, V39, P1202, DOI 10.1038/ng2109
Dolen G, 2008, J PHYSIOL-LONDON, V586, P1503, DOI 10.1113/jphysiol.2008.150722
Dudbridge F, 2008, HUM HERED, V66, P87, DOI 10.1159/000119108
Durand CM, 2012, MOL PSYCHIATR, V17, P71, DOI 10.1038/mp.2011.57
Ebert DH, 2013, NATURE, V493, P327, DOI 10.1038/nature11860
Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
Feliciano DM, 2009, J BIOL CHEM, V284, P26466, DOI 10.1074/jbc.M109.027680
Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
Gabut M, 2005, MOL CELL BIOL, V25, P3286, DOI 10.1128/MCB.25.8.3286-3294.2005
Gai X, 2012, MOL PSYCHIATR, V17, P402, DOI 10.1038/mp.2011.10
Gauderman WJ, 2002, AM J EPIDEMIOL, V155, P478, DOI 10.1093/aje/155.5.478
Graveley BR, 2000, RNA, V6, P1197, DOI 10.1017/S1355838200000960
Gutierrez RC, 2009, NEUROSCIENCE, V162, P208, DOI 10.1016/j.neuroscience.2009.04.062
Ho N, 2000, J NEUROSCI, V20, P6459
Kalkman HO, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-10
Kelleher RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035003
Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
Klauck SM, 1997, HUM MOL GENET, V6, P2233, DOI 10.1093/hmg/6.13.2233
Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
Knapp M, 2008, HUM HERED, V66, P111, DOI 10.1159/000119110
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
Lemrow SM, 2004, J BIOL CHEM, V279, P11664, DOI 10.1074/jbc.M312613200
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luscher C, 2010, NEURON, V65, P445, DOI 10.1016/j.neuron.2010.01.016
Martins-De-Souza D, 2009, EUR ARCH PSY CLIN N, V259, P151, DOI 10.1007/s00406-008-0847-2
MATTHEWS RP, 1994, MOL CELL BIOL, V14, P6107
McCarthy MI, 2008, NAT REV GENET, V9, P356, DOI 10.1038/nrg2344
Michlewski G, 2008, MOL CELL, V30, P179, DOI 10.1016/j.molcel.2008.03.013
Moffatt MF, 2007, NATURE, V448, P470, DOI 10.1038/nature06014
Munesue T, 2010, NEUROSCI RES, V67, P181, DOI 10.1016/j.neures.2010.03.004
Napoli I, 2008, CELL, V134, P1042, DOI 10.1016/j.cell.2008.07.031
Narayanan U, 2007, J NEUROSCI, V27, P14349, DOI 10.1523/JNEUROSCI.2969-07.2007
Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
Nowicki ST, 2007, J DEV BEHAV PEDIATR, V28, P133, DOI 10.1097/01.DBP.0000267563.18952.c9
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Poustka F, 1996, PSYCHOPATHOLOGY, V29, P145
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
SAS Institute Inc, 2009, SAS STAT 9 2 US GUID, Vsecond
Schenck A, 2003, NEURON, V38, P887, DOI 10.1016/S0896-6273(03)00354-4
SUN ZM, 1995, MOL CELL BIOL, V15, P561
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Thomas AM, 2011, BEHAV BRAIN RES, V223, P310, DOI 10.1016/j.bbr.2011.04.049
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
van der Zwaag B, 2010, AM J MED GENET B, V153B, P960, DOI 10.1002/ajmg.b.31055
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Wang HS, 2008, J NEUROSCI, V28, P4385, DOI 10.1523/JNEUROSCI.0646-08.2008
Wang HS, 2009, J BIOL CHEM, V284, P18953, DOI 10.1074/jbc.M109.019141
Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
Waung MW, 2009, CURR OPIN NEUROBIOL, V19, P319, DOI 10.1016/j.conb.2009.03.011
WHO, 1993, ICD 10 CLASS MENT BE
Wu JY, 2000, J BIOL CHEM, V275, P7994, DOI 10.1074/jbc.275.11.7994
Wu S, 2012, CELL RES, V22, P1270, DOI 10.1038/cr.2012.47
Yu JK, 2009, J BIOL CHEM, V284, P1505, DOI 10.1074/jbc.M805113200
NR 77
TC 4
Z9 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD JUN
PY 2014
VL 133
IS 6
BP 781
EP 792
DI 10.1007/s00439-013-1416-y
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA AH7MI
UT WOS:000336317000010
PM 24442360
ER
PT J
AU Cridland, EK
Jones, SC
Caputi, P
Magee, CA
AF Cridland, Elizabeth K.
Jones, Sandra C.
Caputi, Peter
Magee, Christopher A.
TI Being a Girl in a Boys' World: Investigating the Experiences of Girls
with Autism Spectrum Disorders During Adolescence
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Female; Girl; Adolescence; Qualitative; Family systems
ID HIGH-FUNCTIONING CHILDREN; PERVASIVE DEVELOPMENTAL DISORDERS;
QUALITY-OF-LIFE; ASPERGER-SYNDROME; SEX-DIFFERENCES; PARENTAL
PERSPECTIVE; SEXUALITY EDUCATION; SOCIAL STORIES; AMBIGUOUS LOSS;
PERCEPTIONS
AB This study investigates the experiences of adolescent girls with autism spectrum disorders (ASD) during adolescence. Semi-structured interviews were conducted with three mother-daughter dyads and two additional mothers. A range of issues were highlighted covering physical, emotional, social and sexual domains. Some of these issues were similar to those experienced by boys with ASD during adolescence, such as negative implications of late diagnosis, challenges of transitioning to and coping with high school, 'hands-on' role of parents into adolescence, difficulties adjusting to the increased demands of adolescent hygiene routines, and the importance of learning personal boundaries in interactions with others. Other issues discussed were of particular relevance to adolescent girls with ASD, such as difficulties socialising with neurotypically developing girls, sex-specific puberty issues, and sexual vulnerabilities. This study highlights an important research area and is a preliminary step towards understanding the experiences of adolescent girls with ASD and their families.
C1 [Cridland, Elizabeth K.; Caputi, Peter] Univ Wollongong, Sch Psychol, Wollongong, NSW, Australia.
[Cridland, Elizabeth K.; Jones, Sandra C.; Caputi, Peter; Magee, Christopher A.] Univ Wollongong, Ctr Hlth Initiat, Wollongong, NSW, Australia.
RP Cridland, EK (reprint author), Univ Wollongong, Sch Psychol, Wollongong, NSW, Australia.
EM ekc977@uowmail.edu.au
RI Jones, Sandra/D-3854-2011
OI Jones, Sandra/0000-0002-0258-3348
CR Adreon D, 2001, INTERV SCH CLIN, V36, P266, DOI 10.1177/105345120103600502
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Attwood T., 2013, PATTERN ABILITIES DE
Attwood T., 2012, SAFETY SKILLS ASPERG
Barbour RS, 2000, J EVAL CLIN PRACT, V6, P155
Baron-Cohen SB, 2011, PLOS BIOL, V9, P1, DOI DOI 10.1371/JOURNAL.PBIO.1001081
Bauminger N, 2008, J AUTISM DEV DISORD, V38, P1211, DOI 10.1007/s10803-007-0501-2
Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
Bauminger N, 2004, J DEV PHYS DISABIL, V16, P193, DOI 10.1023/B:JODD.0000026616.24896.c8
Begeer S, 2013, J AUTISM DEV DISORD, V43, P1151, DOI 10.1007/s10803-012-1656-z
Berger O., 2007, RES DEV DISABIL, V29, P289
Bolick T., 2001, ASPERGER SYNDROME AD
Boss P, 2004, J MARRIAGE FAM, V66, P551, DOI 10.1111/j.0022-2445.2004.00037.x
Boss P.G., 1999, AMBIGUOUS LOSS LEARN
Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
Brewin BJ, 2008, FOCUS AUTISM DEV DIS, V23, P242, DOI 10.1177/1088357608322997
Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
Card NA, 2008, CHILD DEV, V79, P1185, DOI 10.1111/j.1467-8624.2008.01184.x
Carrington S, 2001, AUTISM, V5, P37, DOI 10.1177/1362361301005001004
Carrington S., 2003, FOCUS AUTISM OTHER D, V18, P211, DOI 10.1177/10883576030180040201
Caterino L. C., 2008, ED TREATMENT CHILDRE, V31, P381
Chan JM, 2009, RES AUTISM SPECT DIS, V3, P876, DOI 10.1016/j.rasd.2009.04.003
Cottenceau H, 2012, EUR CHILD ADOLES PSY, V21, P289, DOI 10.1007/s00787-012-0263-z
Cridland EK, 2014, AUTISM, V18, P213, DOI 10.1177/1362361312472261
Fombonne E., 2002, MOL PSYCHIAT S, V7, P4
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Hellemans H, 2007, J AUTISM DEV DISORD, V37, P260, DOI 10.1007/s10803-006-0159-1
Holliday-Willey L., 1999, PRETENDING BE NORMAL
Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361
Hsiao MN, 2013, RES DEV DISABIL, V34, P254, DOI 10.1016/j.ridd.2012.08.001
Humphrey N., 2008, SUPPORT LEARNING, V23, P41, DOI DOI 10.1111/11467-9604.2007.00367.X
Humphrey N, 2010, J RES SPECIAL ED NEE, V10, P82, DOI DOI 10.1111/J.1471-3802.2010.01146.X
John R. M., 2012, J NURSE PRACTITIONER, V8, P306, DOI DOI 10.1016/J.NURPRA.2012.01.020
Kabot S, 2003, PROF PSYCHOL-RES PR, V34, P26, DOI 10.1037/0735-7028.34.1.26
Klett LS, 2012, SEX DISABIL, V30, P319, DOI 10.1007/s11195-011-9244-2
Knickmeyer RC, 2008, J AUTISM DEV DISORD, V38, P1028, DOI 10.1007/s10803-007-0475-0
Koller R, 2000, SEX DISABIL, V18, P125, DOI 10.1023/A:1005567030442
Koning C, 2001, AUTISM, V5, P23, DOI 10.1177/1362361301005001003
Krahn TM, 2012, J BIOETHIC INQ, V9, P93, DOI 10.1007/s11673-011-9350-y
Lasgaard M, 2010, J AUTISM DEV DISORD, V40, P218, DOI 10.1007/s10803-009-0851-z
Mascha K, 2006, BRIT J DEV DISABIL, V52, P19
Mattila ML, 2007, J AM ACAD CHILD PSY, V46, P636, DOI 10.1097/chi.0b013e318033ff42
MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216
Muller E, 2008, AUTISM, V12, P173, DOI 10.1177/1362361307086664
Murphy NA, 2006, PEDIATRICS, V118, P398, DOI 10.1542/peds.2006-1115
Nichols S., 2009, GIRLS GROWING AUTISM
Nichols S., 2010, SOCIAL WORK MENTAL H, V8, P72
O'Brien M, 2007, FAM RELAT, V56, P135
Oliver M., 1992, DISABILITY HANDICAP, V7, P101, DOI DOI 10.1080/02674649266780141
Petalas MA, 2009, INT J DISABIL DEV ED, V56, P381, DOI 10.1080/10349120903306715
Petalas MA, 2012, J INTELLECT DEV DIS, V37, P303, DOI 10.3109/13668250.2012.734603
Pinkerton J, 2007, CHILD FAM SOC WORK, V12, P219, DOI 10.1111/j.1365-2206.2007.00497.x
QSR International, 2012, NVIVO 10 VERS 10
Rivet TT, 2011, RES AUTISM SPECT DIS, V5, P957, DOI 10.1016/j.rasd.2010.12.003
Rivet TT, 2011, J DEV PHYS DISABIL, V23, P399, DOI 10.1007/s10882-011-9235-3
RUBLE LA, 1993, ARCH SEX BEHAV, V22, P229, DOI 10.1007/BF01541768
Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
Smith J. A., 1999, QUALITATIVE HLTH PSY, P219
Smith JA, 1996, PSYCHOL HEALTH, V11, P261, DOI 10.1080/08870449608400256
Solomon M, 2012, J AUTISM DEV DISORD, V42, P48, DOI 10.1007/s10803-011-1215-z
Stokes MA, 2005, AUTISM, V9, P266, DOI 10.1177/1362361305053258
Tarnai B, 2008, SEX DISABIL, V26, P29, DOI 10.1007/s11195-007-9067-3
Travers J, 2010, EDUC TRAIN AUTISM DE, V45, P284
VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103
Willey L. H., 2003, ASPERGER SYNDROME AD
William M., 2012, J AUTISM DEV DISORD, V42, P1304
NR 66
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1261
EP 1274
DI 10.1007/s10803-013-1985-6
PG 14
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400001
PM 24221816
ER
PT J
AU Harris, B
Barton, EE
Albert, C
AF Harris, Bryn
Barton, Erin E.
Albert, Chantel
TI Evaluating Autism Diagnostic and Screening Tools for Cultural and
Linguistic Responsiveness
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Diagnostic assessment; Screening; Diverse populations
ID SPECTRUM DISORDERS; CHILDREN; IDENTIFICATION; AGE; CHECKLIST; TODDLERS;
ISSUES; MODEL
AB While clear guidelines and best practices exist for the assessment of autism spectrum disorders (ASD), little information is available about assessing for ASD in culturally and linguistically diverse (CLD) populations. CLD populations might be misidentified and under-identified with ASD due to the assessment practices that we employ. Four autism diagnostic tools and six autism screeners were selected and evaluated for their cultural and linguistic responsiveness. Although the evaluation of ASD within CLD populations is highly complex, this study identified the need for improved autism assessment tools and practices. Without the appropriate assessment of these populations, CLD children will likely continue to be misidentified (or not identified at all) and will miss crucial intervention opportunities.
C1 [Harris, Bryn; Albert, Chantel] Univ Colorado, Denver, CO 80217 USA.
[Barton, Erin E.] Vanderbilt Univ, Nashville, TN 37203 USA.
RP Harris, B (reprint author), Univ Colorado, 1380 Lawrence St 1114, Denver, CO 80217 USA.
EM bryn.harris@ucdenver.edu; erin.e.barton@vanderbilt.edu;
chantel.albert@ucdenver.edu
CR Abedi J., 2005, 663 CSE U CAL CTR RE
AERA (American Education Research Association) APA and The National Council on Measurement in Education, 1999, STAND ED PSYCH TEST
Allen RA, 2008, PSYCHOL SCHOOLS, V45, P905, DOI 10.1002/pits.20341
Allison C, 2008, J AUTISM DEV DISORD, V38, P1414, DOI 10.1007/s10803-007-0509-7
American Educational Research Association, 2011, ED RES, V40, P145, DOI [DOI 10.3102/0013189X11410403, 10.3102/0013189X11410403]
American Psychological Association, 2010, ETH PRINC PSYCH COD
Bagnato S., 1997, LINKING ASSESSMENT E
Bagnato S. J., 1991, ASSESSMENT EARLY INT
Barton E. E., 2013, UNPUB
Begeer S, 2009, J AUTISM DEV DISORD, V39, P142, DOI 10.1007/s10803-008-0611-5
Bradley-Johnson S, 2008, J PSYCHOEDUC ASSESS, V26, P325, DOI 10.1177/0734282908316952
Bronfenbrenner U., 1979, ECOLOGY HUMAN DEV EX
Cawthon S., 2011, SCH PSYCHOL FORUM RE, V5, P114
Coonrod EE, 2004, INFANT YOUNG CHILD, V17, P258
Daley TC, 2004, SOC SCI MED, V58, P1323, DOI 10.1016/S0277-9536(03)00330-7
Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Flanagan D. P., 2013, ESSENTIALS CROSS BAT
Gilliam JE, 2006, GILLIAM AUTISM RATIN
Goldstein S., 2010, AUTISM SPECTRUM RATI
Guiberson M., 2012, YOUNG EXCEPTIONAL CH, V15, P33, DOI [10.1177/1096250611435368, DOI 10.1177/1096250611435368]
Harris B., 2012, MONOGRAPH DEC, V14, P93
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kennedy C, 2005, SINGLE CASE DESIGNS
Lord C., 2008, AUTISM DIAGNOSTIC OB
Mandell DS, 2010, J AUTISM DEV DISORD, V40, P1241, DOI 10.1007/s10803-010-0982-2
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P1598, DOI 10.1016/j.rasd.2011.03.007
McLean M., 1998, YOUNG EXCEPTIONAL CH, V1, P20, DOI 10.1177/109625069800100304
McLean M. E., 2005, DEC RECOMMENDED PRAC
Morrier MJ, 2012, J SPEC EDUC, V46, P49, DOI 10.1177/0022466910372137
Morrier M. J., 2008, MULTICULTURAL ED, V16, P31
Norbury CF, 2013, DEV PSYCHOL, V49, P45, DOI 10.1037/a0027446
Overton T, 2007, J AUTISM DEV DISORD, V37, P1996, DOI 10.1007/s10803-006-0349-x
Ozonoff S, 2005, J CLIN CHILD ADOLESC, V34, P523, DOI 10.1207/s15374424jccp3403_8
Palmer RF, 2005, AM J PUBLIC HEALTH, V95, P125, DOI 10.2105/AJPH.2003.023077
Rhodes R. L., 2005, ASSESSING CULTURALLY
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Rutter M., 2003, SOCIAL COMMUNICATION
Sattler J. M., 2008, ASSESSMENT CHILDREN, V5th
Schopler E., 2010, CARS 2 CHILDHOOD AUT
Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
Squire J, 2003, ASQ SE USERS GUIDE A
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Vismara LA, 2008, J EARLY INTERVENTION, V31, P91, DOI 10.1177/1053815108325578
Zhang J., 2006, INT J SPECIAL ED, V21, P109
NR 47
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1275
EP 1287
DI 10.1007/s10803-013-1991-8
PG 13
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400002
PM 24186120
ER
PT J
AU Latham, SO
Stockman, IJ
AF Latham, Susan O.
Stockman, Ida J.
TI Effect of Augmented Sensorimotor Input on Learning Verbal and Nonverbal
Tasks Among Children with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Sensorimotor; Tactile-kinesthetic; PROMPT;
Verbal/nonverbal learning
ID OBJECT RECOGNITION; ABNORMALITIES; INTERVENTIONS; DISABILITIES;
EXPLORATION; HAPTICS; MEMORY
AB Thirty-four children, with autism spectrum disorders, ages 4-14 years, were matched and randomly assigned to one of two conditions for learning a novel juice-making task and producing two novel words about the event. Seventeen sighted children were manually guided to perform the task and tactually prompted during imitated productions of novel words for the event. Their matched controls heard the novel words and watched the juice-making task being performed. Performances on four verbal and two nonverbal measures right after instruction and at 24-48 h post-instruction, revealed higher scores for the "hands-on", participation than observation group on both verbal and nonverbal tasks. This study offers a paradigm for exploring the instructional advantage of enhanced participatory experience.
C1 [Latham, Susan O.] St Marys Coll, Dept Communicat Sci & Disorders, Notre Dame, IN 46556 USA.
[Stockman, Ida J.] Michigan State Univ, Dept Communicat Sci & Disorders, E Lansing, MI 48824 USA.
RP Latham, SO (reprint author), St Marys Coll, Dept Communicat Sci & Disorders, 157 Madeleva Hall, Notre Dame, IN 46556 USA.
EM slatham@saintmarys.edu; stockma1@msu.edu
CR Affolter F., 1991, PERCEPTION INTERACTI
Affolter F, 2000, NONVERBAL PERCEPTUAL
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Bara F, 2004, COGNITIVE DEV, V19, P433, DOI 10.1016/j.cogdev.2004.05.003
Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
Bishop D., 1993, LANGUAGE DEV EXCEPTI, P239
Bloom L, 2001, MONOGRAPHS SOC RES C, V66, p[i, 1], DOI DOI 10.1111/1540-5834.00163
Brownell R., 2000, RECEPTIVE ONE WORD P
Brownell R, 2000, EXPRESSIVE ONE WORD, V3rd
Childers J. B., 2006, ACTION MEETS WORD CH, P331
Craddock M, 2011, PERCEPTION, V40, P1154, DOI 10.1068/p6974
Dijkerman HC, 2007, BEHAV BRAIN SCI, V30, P189, DOI 10.1017/S0140525X07001392
Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
Elliot C. D, 2007, DIFFERENTIAL ABILITI
Fisher A. G., 1991, SENSORY INTEGRATION
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Gantz M., 2006, UNDERSTANDING AUTISM
Glenberg AM, 2004, J EDUC PSYCHOL, V96, P424, DOI 10.1037/0022-0663.96.3.424
Glenberg AM, 2002, PSYCHON B REV, V9, P558, DOI 10.3758/BF03196313
Grand S., 2007, BODY SHAPES WAY WE T
Hammill D., 1997, TEST LANGUAGE DEV RE
Hayden D, 2006, ADV SPEECH LANGUAGE, V8, P265, DOI 10.1080/14417040600861094
Hayden D., 2003, INTRO PROMPT TECHNIQ
HOEHN TP, 1994, J LEARN DISABIL, V27, P338
James KH, 2002, BEHAV RES METH INS C, V34, P383, DOI 10.3758/BF03195466
Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
Jonides J, 1998, J NEUROSCI, V18, P5026
Kaufman AS, 1983, KAUFMAN ASSESSMENT B
KLATZKY RL, 1987, J EXP PSYCHOL GEN, V116, P356
Ladefoged P., 2001, VOWELS CONSONANTS IN
LEDERMAN SJ, 1987, COGNITIVE PSYCHOL, V19, P342, DOI 10.1016/0010-0285(87)90008-9
Liu CH, 2007, J EXP PSYCHOL HUMAN, V33, P895, DOI 10.1037/0096-1523.33.4.895
Minogue J, 2006, REV EDUC RES, V76, P317, DOI 10.3102/00346543076003317
Nelson K., 1986, EVENT KNOWLEDGE STRU
Newborg J, 2004, BATTELLE DEV INVENTO
Noe A., 2004, ACTION PERCEPTION
ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170
Pan CY, 2008, J AUTISM DEV DISORD, V38, P1292, DOI 10.1007/s10803-007-0518-6
Rogers SJ, 2006, J AUTISM DEV DISORD, V36, P1007, DOI 10.1007/s10803-006-0142-x
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
Rossetti L, 1990, ROSSETTI INFANT TODD
Semel E., 1987, CLIN EVALUATION LANG
Siaperas P, 2012, J AUTISM DEV DISORD, V42, P718, DOI 10.1007/s10803-011-1301-2
SMIT AB, 1990, J SPEECH HEAR DISORD, V55, P779
St Louis K. O., 1987, ORAL SPEECH MECH SCR
Stockman I. J., 2004, MOVEMENT ACTION LEAR
Stockman I. J., 2000, NONVERBAL PERCEPTUAL, P197
THELEN E, 1995, AM PSYCHOL, V50, P79, DOI 10.1037//0003-066X.50.2.79
Thelen E., 1994, DYNAMIC SYSTEMS APPR
Thorndike RL, 1986, STANFORD BINET INTEL
Tomasello M., 1995, NAMES THINGS YOUNG C
Waterhouse L, 1996, PSYCHOL REV, V103, P457, DOI 10.1037/0033-295X.103.3.457
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Wiggins LD, 2009, J AUTISM DEV DISORD, V39, P1087, DOI 10.1007/s10803-009-0711-x
Wilson M, 2002, PSYCHON B REV, V9, P625, DOI 10.3758/BF03196322
NR 55
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1288
EP 1302
DI 10.1007/s10803-013-1990-9
PG 15
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400003
PM 24234676
ER
PT J
AU El Zein, F
Solis, M
Vaughn, S
McCulley, L
AF El Zein, Farah
Solis, Michael
Vaughn, Sharon
McCulley, Lisa
TI Reading Comprehension Interventions for Students with Autism Spectrum
Disorders: A Synthesis of Research
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Reading comprehension; Reading intervention;
Synthesis
ID HIGH-FUNCTIONING AUTISM; INTEGRATION STRATEGY; ASPERGER-SYNDROME; SCHOOL
STUDENTS; SIMPLE VIEW; CHILDREN; INDIVIDUALS; INSTRUCTION; HYPERLEXIA;
LANGUAGE
AB The authors synthesized reading intervention studies conducted between 1980 and 2012 with K-12 students identified with autism spectrum disorders (ASD). Nine single-subject design studies, one quasi-experimental study, and two single-group design studies met the criteria for inclusion. Findings from the studies indicate that modifying instructional interventions associated with improved comprehension for students with reading difficulties may improve reading comprehension in students with ASD. Four studies implemented strategy instruction that included (a) question generation; (b) graphic organizers; and (c) making predictions. Two studies utilized anaphoric cueing instruction, three implemented explicit instruction, and three examined student grouping practices. Among the reviewed studies, the majority (n = 9) measured reading comprehension through researcher-developed probes, and two studies reported results from standardized measures.
C1 [El Zein, Farah; Solis, Michael; Vaughn, Sharon; McCulley, Lisa] Univ Texas Austin, Coll Educ, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
RP El Zein, F (reprint author), Univ Texas Austin, Coll Educ, Meadows Ctr Preventing Educ Risk, SZB 308 A,1 Univ Stn D4900, Austin, TX 78712 USA.
EM zein_farah@hotmail.com
CR Al Otaiba S, 2002, REM SPEC EDUC, V23, P300, DOI 10.1177/07419325020230050501
Armstrong T., 2009, MULTIPLE INTELLIGENC
Asberg J., 2010, J RES SPECIAL ED NEE, V10, P91, DOI [10.1111/j.1471-3802.2020.01147.x, DOI 10.1111/J.1471-3802.2010.01147.X, 10.1111/j.1471-3802.2010.01147.x]
BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
Browder DM, 2006, EXCEPT CHILDREN, V72, P392
Campbell M. A., 2010, THESIS FAIRLEIGH DIC
Carnahan C., 2010, QUALITY LITERACY INS, P21
Carnahan C., 2009, EDUC TREAT CHILD, V32, P37, DOI [DOI 10.1353/ETC.0.0047, 10.1353/etc.0.0047]
Catts HW, 2006, J SPEECH LANG HEAR R, V49, P278, DOI 10.1044/1092-4388(2006/023)
Centers for Disease Control and Prevention, 2009, AUT DEV DIS MON NETW, V58, P1
Chen RS, 1997, J LIT RES, V29, P1
Chiang H., 2007, FOCUS AUTISM OTHER D, V22, P259, DOI DOI 10.1177/10883576070220040801
Clarke PJ, 2010, PSYCHOL SCI, V21, P1106, DOI 10.1177/0956797610375449
Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
CURTIS ME, 1980, J EDUC PSYCHOL, V72, P656, DOI 10.1037/0022-0663.72.5.656
Cutting LE, 2006, SCI STUD READ, V10, P277, DOI 10.1207/s1532799xssr1003_5
Edmonds MS, 2009, REV EDUC RES, V79, P262, DOI 10.3102/0034654308325998
Flores M. M., 2007, FOCUS AUTISM OTHER D, V22, P244, DOI 10.1177/10883576070220040601
Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x
Franzen KM, 1996, CHILD NEUROPSYCHOL, V2, P176, DOI 10.1080/09297049608402250
Frith U., 1983, BRIT J DEV PSYCHOL, V1, P329, DOI 10.1111/j.2044-835X.1983.tb00906.x
Frith U., 1989, AUTISM EXPLAINING EN
Ganz JB, 2009, J AUTISM DEV DISORD, V39, P75, DOI 10.1007/s10803-008-0602-6
Gately S. E., 2008, EXCEPT CHILDREN, V40, P40
GERNSBACHER MA, 1990, J EXP PSYCHOL LEARN, V16, P430, DOI 10.1037//0278-7393.16.3.430
Ghaziuddin M, 2004, J AUTISM DEV DISORD, V34, P279, DOI 10.1023/B:JADD.0000029550.19098.77
GOLDBERG TE, 1987, J AUTISM DEV DISORD, V17, P29, DOI 10.1007/BF01487258
Gough P. B., 1986, RASE, V7, P6, DOI DOI 10.1177/074193258600700104
Grigorenko EL, 2003, J CHILD PSYCHOL PSYC, V44, P1079, DOI 10.1111/1469-7610.00193
Grigorenko EL, 2002, J AUTISM DEV DISORD, V32, P3, DOI 10.1023/A:1017995805511
Gwet K., 2001, STAT TABLES INTER RA
Happe F., 2005, HDB AUTISM PERVASIVE, P640
Hedges L, 1985, STAT METHODS METAANA
Kamps DM, 1995, BEHAV DISORDERS, V21, P89
KAMPS DM, 1994, J APPL BEHAV ANAL, V27, P49, DOI 10.1901/jaba.1994.27-49
Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
Knight V. F., 2010, THESIS U N CAROLINA
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Kratochwill T. R., 2010, SINGLE CASE DESIGNS
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
Lipsey M. W., 2001, PRACTICAL METAANALYS
MCGEE GG, 1986, J APPL BEHAV ANAL, V19, P147, DOI 10.1901/jaba.1986.19-147
Millar DC, 2006, J SPEECH LANG HEAR R, V49, P248, DOI 10.1044/1092-4388(2006/021)
MINSHEW NJ, 1994, J CLIN EXP NEUROPSYC, V16, P261, DOI 10.1080/01688639408402637
Mirenda P, 2003, TOP LANG DISORD, V23, P271
Nation K, 2006, J AUTISM DEV DISORD, V36, P911, DOI 10.1007/s10803-006-0130-1
National Reading Panel (US) & International Reading Association, 2002, EVIDENCE BASED READI
Newman TM, 2007, J AUTISM DEV DISORD, V37, P760, DOI 10.1007/s10803-006-0206-y
Norbury C, 2011, SCI STUD READ, V15, P191, DOI 10.1080/10888431003623553
O'Connor IM, 2004, J AUTISM DEV DISORD, V34, P115, DOI 10.1023/B:JADD.0000022603.44077.6b
OCONNOR N, 1994, J AUTISM DEV DISORD, V24, P501, DOI 10.1007/BF02172131
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
Ozonoff S, 2003, AUTISM SPECTRUM DISORDERS, P3
PATTI PJ, 1993, J AUTISM DEV DISORD, V23, P397, DOI 10.1007/BF01046228
Pennington B. F., 1997, AUTISM EXECUTIVE DIS, P143
Perfetti C. A., 2013, SCI READING HDB, P336
Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
Ramps D., 1989, ED TREATMENT CHILDRE, V12, P38
Ricketts J, 2013, J AUTISM DEV DISORD, V43, P807, DOI 10.1007/s10803-012-1619-4
Scammacca N., 2007, INTERVENTION ADOLESC
Schlosser R., 2007, EVIDENCE BASED COMMU, V1, P52, DOI 10.1080/17489530701269748
Scruggs TE, 1998, BEHAV MODIF, V22, P221, DOI 10.1177/01454455980223001
SNOWLING M, 1986, J EXP CHILD PSYCHOL, V42, P392, DOI 10.1016/0022-0965(86)90033-0
Solis M, 2012, J LEARN DISABIL-US, V45, P327, DOI 10.1177/0022219411402691
Sticht T., 1984, HDB READING RES, P293
Stringfield SG, 2011, FOCUS AUTISM DEV DIS, V26, P218, DOI 10.1177/1088357611423543
Tsatsanis K., 2005, HDB AUTISM PERVASIVE, V1, P365
Van Riper I., 2010, THESIS WIDENER U CHE
Vaughn S, 2012, J LEARN DISABIL-US, V45, P244, DOI 10.1177/0022219412442157
Vernon D. S., 1996, SCORE SKILLS SOCIAL
Wahlberg T, 2004, DISCOURSE PROCESS, V38, P119, DOI 10.1207/s15326950dp3801_5
Whalon K, 2008, EDUC TRAIN DEV DISAB, V43, P367
Whalon KJ, 2009, FOCUS AUTISM DEV DIS, V24, P3, DOI 10.1177/1088357608328515
WHITEHOUSE D, 1984, J AUTISM DEV DISORD, V14, P281, DOI 10.1007/BF02409579
Williamson P., 2009, COUNC EXC CHILD C SE
NR 76
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1303
EP 1322
DI 10.1007/s10803-013-1989-2
PG 20
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400004
PM 24218240
ER
PT J
AU Fujiwara, T
AF Fujiwara, Takeo
TI Socioeconomic Status and the Risk of Suspected Autism Spectrum Disorders
Among 18-Month-Old Toddlers in Japan: A Population-Based Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorders; Epidemiology; Health care system;
Socioeconomic status
ID PERVASIVE DEVELOPMENTAL DISORDERS; SOCIAL-CLASS; MODIFIED CHECKLIST;
INFANTILE-AUTISM; BIRTH COHORT; CHILDREN; CALIFORNIA; STRESS;
NEURODEVELOPMENT; DIAGNOSIS
AB The association between family socioeconomic status (SES) and the suspected autism spectrum disorder (ASD) status of 18-month-old toddlers was investigated using a population-based sample in Japan, which has a universal healthcare system and a mandatory health checkup system for toddlers. Questionnaires including SES measurements and modified checklist for autism in toddlers were mailed to all families with 18-month-old toddlers in Chiba, a city near Tokyo (N = 6,061; response rate: 64 %). The results of logistic regression analysis (which were adjusted for potential confounders) indicated that low maternal education, but not paternal education or family income, were associated with having suspected ASD offspring. Lower maternal education was associated with an increased risk of autistic traits in Japan.
C1 Natl Res Inst Child Hlth & Dev, Dept Social Med, Setagaya Ku, Tokyo 1578535, Japan.
RP Fujiwara, T (reprint author), Natl Res Inst Child Hlth & Dev, Dept Social Med, Setagaya Ku, 2-10-1 Okura, Tokyo 1578535, Japan.
EM fujiwara-tk@ncchd.go.jp
CR Adams JB, 2007, J TOXICOL ENV HEAL A, V70, P1046, DOI 10.1080/15287390601172080
Bhasin TK, 2007, J AUTISM DEV DISORD, V37, P667, DOI 10.1007/s10803-006-0194-y
Burd L, 1999, J PERINAT MED, V27, P441, DOI 10.1515/JPM.1999.059
Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
Curtis LT, 2008, J ALTERN COMPLEM MED, V14, P79, DOI 10.1089/acm.2007.0610
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dodds L, 2011, J AUTISM DEV DISORD, V41, P891, DOI 10.1007/s10803-010-1114-8
Durkin MS, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011551
Emerson E, 2012, J EPIDEMIOL COMMUN H, V66, P218, DOI 10.1136/jech.2010.111773
Eskenazi B, 2007, ENVIRON HEALTH PERSP, V115, P792, DOI 10.1289/ehp.9828
Filipek PA, 2004, J AUTISM DEV DISORD, V34, P615, DOI 10.1007/s10803-004-5283-1
Fountain C, 2011, J EPIDEMIOL COMMUN H, V65, P503, DOI 10.1136/jech.2009.104588
GILLBERG C, 1982, J AUTISM DEV DISORD, V12, P223, DOI 10.1007/BF01531368
HOSHINO Y, 1982, FOLIA PSYCHIAT NEU J, V36, P115
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Inada N, 2011, RES AUTISM SPECT DIS, V5, P330, DOI 10.1016/j.rasd.2010.04.016
Iwasaki M, 2002, INT J EPIDEMIOL, V31, P1208, DOI 10.1093/ije/31.6.1208
Jwa SC, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-389
Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
Lampi KM, 2013, J AUTISM DEV DISORD, V43, P2526, DOI 10.1007/s10803-013-1801-3
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
May T, 2013, J AUTISM DEV DISORD, V43, P2147, DOI 10.1007/s10803-013-1766-2
Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
Ministry of Health Labor and Welfare, 2012, INC DISTR
Ministry of Health Labor and Welfare, 2011, REP COMM HLTH HLTH P
Moore CJ, 2012, J ACAD NUTR DIET, V112, P518, DOI 10.1016/j.jand.2011.12.001
Murakami K, 2009, NUTR RES, V29, P164, DOI 10.1016/j.nutres.2009.02.002
Palmer RF, 2006, HEALTH PLACE, V12, P203, DOI 10.1016/j.healthplace.2004.11.005
Pinborough-Zimmerman J, 2011, AUTISM RES, V4, P438, DOI 10.1002/aur.224
Pinborough-Zimmerman J, 2010, MATERN CHILD HLTH J, V14, P392, DOI 10.1007/s10995-009-0472-3
Rai D, 2012, J AM ACAD CHILD PSY, V51, P467, DOI 10.1016/j.jaac.2012.02.012
Rauh VA, 2006, PEDIATRICS, V118, pE1845, DOI 10.1542/peds.2006-0338
Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Sauer C, 2012, NEUROPSYCHOPHARMACOL, V37, P1474, DOI 10.1038/npp.2011.333
Scarpa A, 2013, J AUTISM DEV DISORD, V43, P2269, DOI 10.1007/s10803-013-1779-x
SCHOPLER E, 1979, J AUTISM DEV DISORD, V9, P139, DOI 10.1007/BF01531530
Schultz Stephen T, 2006, Int Breastfeed J, V1, P16, DOI 10.1186/1746-4358-1-16
Strambi M, 2006, BIOL TRACE ELEM RES, V109, P97, DOI 10.1385/BTER:109:2:097
Sullivan A, 2012, J APPL RES INTELLECT, V25, P484, DOI 10.1111/j.1468-3148.2012.00695.x
Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
TSAI L, 1982, J AUTISM DEV DISORD, V12, P211, DOI 10.1007/BF01531367
Van Meter KC, 2010, AUTISM RES, V3, P19, DOI 10.1002/aur.110
Windham GC, 2011, J AUTISM DEV DISORD, V41, P1362, DOI 10.1007/s10803-010-1160-2
WING L, 1980, BRIT J PSYCHIAT, V137, P410, DOI 10.1192/bjp.137.5.410
NR 48
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1323
EP 1331
DI 10.1007/s10803-013-1988-3
PG 9
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400005
PM 24202730
ER
PT J
AU Tseng, A
Bansal, R
Liu, J
Gerber, AJ
Goh, S
Posner, J
Colibazzi, T
Algermissen, M
Chiang, IC
Russell, JA
Peterson, BS
AF Tseng, Angela
Bansal, Ravi
Liu, Jun
Gerber, Andrew J.
Goh, Suzanne
Posner, Jonathan
Colibazzi, Tiziano
Algermissen, Molly
Chiang, I-Chin
Russell, James A.
Peterson, Bradley S.
TI Using the Circumplex Model of Affect to Study Valence and Arousal
Ratings of Emotional Faces by Children and Adults with Autism Spectrum
Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Circumplex model of affect; Valence; Arousal; Autism spectrum disorders;
Facial emotion
ID HIGH-FUNCTIONING AUTISM; DIAGNOSTIC OBSERVATION SCHEDULE; SYSTEMS
SUBSERVING VALENCE; FACIAL EXPRESSIONS; BASIC EMOTIONS; AFFECTIVE
NEUROSCIENCE; ASPERGER-SYNDROME; SOCIAL-BEHAVIOR; RECOGNITION;
PERCEPTION
AB The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group's ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence.
C1 [Tseng, Angela; Bansal, Ravi; Liu, Jun; Gerber, Andrew J.; Goh, Suzanne; Posner, Jonathan; Colibazzi, Tiziano; Algermissen, Molly; Chiang, I-Chin; Peterson, Bradley S.] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA.
[Russell, James A.] Boston Coll, Dept Psychol, Boston, MA USA.
RP Tseng, A (reprint author), Columbia Univ Coll Phys & Surg, Unit 78,1051 Riverside Dr, New York, NY 10032 USA.
EM tsengan@nyspi.columbia.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
Barrett LF, 2006, CURR DIR PSYCHOL SCI, V15, P79, DOI 10.1111/j.0963-7214.2006.00411.x
Batty M, 2006, DEVELOPMENTAL SCI, V9, P207, DOI 10.1111/j.1467-7687.2006.00480.x
Beauchaine TP, 2011, DEV PSYCHOPATHOL, V23, P975, DOI 10.1017/S0954579411000459
Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2
Berridge KC, 2003, SER AFFECTIVE SCI, P25
Blair RJR, 1999, PERS INDIV DIFFER, V26, P477, DOI 10.1016/S0191-8869(98)00154-8
Bolte S, 2008, J AUTISM DEV DISORD, V38, P776, DOI 10.1007/s10803-007-0443-8
Burack JA, 2004, J AUTISM DEV DISORD, V34, P65, DOI 10.1023/B:JADD.0000018076.90715.00
Cacioppo J. T., 2000, HDB EMOTIONS, P173
CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
CAREY S, 1992, PHILOS T ROY SOC B, V335, P95, DOI 10.1098/rstb.1992.0012
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
Colibazzi T, 2010, EMOTION, V10, P377, DOI 10.1037/a0018484
Constantino JN, 2005, SOCIAL RESPONSIVENES
Davidson RJ, 2003, BRAIN COGNITION, V52, P129, DOI 10.1016/S0278-2626(03)00015-0
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Ekman P., 1976, PICTURES FACIAL AFFE
EKMAN P, 1993, AM PSYCHOL, V48, P384, DOI 10.1037//0003-066X.48.4.384
EKMAN P, 1992, PSYCHOL REV, V99, P550, DOI 10.1037/0033-295X.99.3.550
Feldman-Barrett L., 1998, J PERS SOC PSYCHOL, V74, P967, DOI DOI 10.1037/0022-3514.74.4.967
Gerber AJ, 2008, NEUROPSYCHOLOGIA, V46, P2129, DOI 10.1016/j.neuropsychologia.2008.02.032
GIARDINA CR, 1977, COMPUT VISION GRAPH, V6, P277, DOI 10.1016/S0146-664X(77)80029-4
Golan O, 2006, J AUTISM DEV DISORD, V36, P169, DOI 10.1007/s10803-005-0057-y
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
Hobson R. Peter, 1993, AUTISM DEV MIND
Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA
Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649
Humphreys K, 2007, NEUROPSYCHOLOGIA, V45, P685, DOI 10.1016/j.neuropsychologia.2006.08.003
Kaartinen M, 2012, J AUTISM DEV DISORD, V42, P1917, DOI 10.1007/s10803-011-1435-2
Kliemann D, 2010, J NEUROSCI, V30, P12281, DOI 10.1523/JNEUROSCI.0688-10.2010
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kraemer HC, 2000, AM J PSYCHIAT, V157, P163, DOI 10.1176/appi.ajp.157.2.163
Kring AM, 2003, PSYCHOL SCI, V14, P207, DOI 10.1111/1467-9280.02433
KUHL FP, 1982, COMPUT VISION GRAPH, V18, P236, DOI 10.1016/0146-664X(82)90034-X
Kuhn G, 2010, EXP BRAIN RES, V201, P155, DOI 10.1007/s00221-009-2019-7
Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
Lang P.J., 1999, INT AFFECTIVE PICTUR
Legisa J, 2013, J AUTISM DEV DISORD, V43, P869, DOI 10.1007/s10803-012-1629-2
Lioy DT, 2011, AUTON NEUROSCI-BASIC, V161, P55, DOI 10.1016/j.autneu.2011.01.006
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809
Martineau J, 2011, J PSYCHIATR RES, V45, P1077, DOI 10.1016/j.jpsychires.2011.01.008
Ming X, 2011, J CHILD NEUROL, V26, P420, DOI 10.1177/0883073810381921
Ming X, 2005, BRAIN DEV-JPN, V27, P509, DOI 10.1016/j.braindev.2005.01.003
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
ORTONY A, 1990, PSYCHOL REV, V97, P315, DOI 10.1037//0033-295X.97.3.315
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
OZONOFF S, 1990, J CHILD PSYCHOL PSYC, V31, P343, DOI 10.1111/j.1469-7610.1990.tb01574.x
PANKSEPP J, 1992, PSYCHOL REV, V99, P554
Parish-Morris J, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00185
Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
PHILLIPS W, 1992, DEV PSYCHOPATHOL, V4, P375, DOI 10.1017/S0954579400000845
Piepers DW, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00559
Porges SW, 1996, DEV PSYCHOBIOL, V29, P697, DOI 10.1002/(SICI)1098-2302(199612)29:8<697::AID-DEV5>3.0.CO;2-O
Porges SW, 2007, BIOL PSYCHOL, V74, P116, DOI 10.1016/j.biopsycho.2006.06.009
Posner J, 2009, HUM BRAIN MAPP, V30, P883, DOI 10.1002/hbm.20553
Posner J, 2005, DEV PSYCHOPATHOL, V17, P715, DOI 10.1017/S0954579405050340
Riby DM, 2008, J NEUROPSYCHOL, V2, P47, DOI 10.1348/174866407X255690
Rieffe C, 2007, J AUTISM DEV DISORD, V37, P455, DOI 10.1007/s10803-006-0171-5
RUSSELL JA, 1980, J PERS SOC PSYCHOL, V39, P1161, DOI 10.1037/h0077714
RUSSELL JA, 1985, J PERS SOC PSYCHOL, V48, P1290, DOI 10.1037/0022-3514.48.5.1290
RUSSELL JA, 1989, J PERS SOC PSYCHOL, V57, P493, DOI 10.1037/0022-3514.57.3.493
Russell JA, 2005, J CONSCIOUSNESS STUD, V12, P26
Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P187, DOI 10.1007/s10803-006-0151-9
SCHLOSBERG H, 1952, J EXP PSYCHOL, V44, P229, DOI 10.1037/h0055778
Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
Vaughan Van Hecke A., 2009, CHILD DEV, V80, P1118, DOI DOI 10.1111/J.1467-8624.2009.01320.X
Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
WATSON D, 1985, PSYCHOL BULL, V98, P219, DOI 10.1037/0033-2909.98.2.219
Wechsler D, 1999, WECHSLER ABBREVIATED
Wright B, 2008, AUTISM, V12, P607, DOI 10.1177/1362361308097118
NR 85
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1332
EP 1346
DI 10.1007/s10803-013-1993-6
PG 15
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400006
PM 24234677
ER
PT J
AU Wilson, BJ
Manangan, CN
Dauterman, HA
Davis, HN
AF Wilson, Beverly J.
Manangan, Christen N.
Dauterman, Hayley A.
Davis, Heather N.
TI ADHD Symptoms Moderate the Relation Between ASD Status and Internalizing
Symptoms in 3-6-Year-Old Children
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Autism; ADHD; Internalizing problems; Depression; Somatization
ID AUTISM SPECTRUM DISORDER; PSYCHIATRIC-DISORDERS; ASPERGER-SYNDROME;
DEPRESSIVE SYMPTOMS; BEHAVIOR CHECKLIST; ANXIETY DISORDERS; ADOLESCENTS;
CHILDHOOD; PREVALENCE; PATTERNS
AB The current study sought to understand the relation between diagnostic status (autism spectrum disorders [ASD] versus typically developing) and internalizing problems in children with and without co-occurring attention deficit hyperactivity disorder (ADHD) symptoms. Participants were 88 children, ages 3:0-6:11, their parents and teachers. Findings indicated that ADHD symptoms moderated the relation between diagnostic status and depressive and somatic symptoms. High ADHD symptoms in children with ASD were associated with increased depressive and somatic symptoms compared to children with typical development. Findings suggest poor prognostic outcomes for children with ASD and co-occurring ADHD symptoms and highlight the need for early identification and targeted intervention.
C1 [Wilson, Beverly J.; Manangan, Christen N.; Dauterman, Hayley A.; Davis, Heather N.] Seattle Pacific Univ, Dept Clin Psychol, Seattle, WA 98119 USA.
RP Wilson, BJ (reprint author), Seattle Pacific Univ, Dept Clin Psychol, 3307 Third Ave West,Suite 107, Seattle, WA 98119 USA.
EM bjwilson@spu.edu
CR Aiken L, 1991, MULTIPLE REGRESSION
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ames C. S., 2010, J AUTISM DEV DISORD, V41, P357, DOI [10.1007/s10803-010-1049-0, DOI 10.1007/S10803-010-1049-0]
Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
Bolton D, 2006, PSYCHOL MED, V36, P335, DOI 10.1017/S0033291705006537
Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
Chapman MV, 2005, J ADOLESCENT HEALTH, V36, P244, DOI 10.1016/j.jadohealth.2004.02.029
Conners C. K., 1997, CONNERS RATING SCALE
Copeland WE, 2009, ARCH GEN PSYCHIAT, V66, P764, DOI 10.1001/archgenpsychiatry.2009.85
Costello E., 1995, EPIDEMIOLOGY ANXIETY, P109
Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837
DELONG GR, 1988, J AUTISM DEV DISORD, V18, P593
Elliott C., 2007, DIFFERENTIAL ABILITY
Estes AM, 2007, AM J MENT RETARD, V112, P439, DOI 10.1352/0895-8017(2007)112[439:LOIFPP]2.0.CO;2
Gadow KD, 2009, J ATTEN DISORD, V12, P474, DOI 10.1177/1087054708320404
Gadow KD, 2012, J AUTISM DEV DISORD, V42, P1353, DOI 10.1007/s10803-011-1367-x
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
Guttmann-Steinmetz S, 2010, J AUTISM DEV DISORD, V40, P1006, DOI 10.1007/s10803-010-0950-x
Hedley D, 2006, AUTISM, V10, P139, DOI 10.1177/1362361306062020
IALONGO N, 1993, DEV PSYCHOPATHOL, V5, P433, DOI 10.1017/S095457940000451X
Kamphaus R., 2004, BASC 2 BEHAV ASSESSM, V2nd
Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
Karustis J. L., 2000, J ATTEN DISORD, V4, P133, DOI DOI 10.1177/108705470000400301
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Krug DA, 1993, AUTISM SCREENING INS
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
LIPOWSKI ZJ, 1988, AM J PSYCHIAT, V145, P1358
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Mazefsky CA, 2011, J PSYCHOPATHOL BEHAV, V33, P31, DOI 10.1007/s10862-010-9198-1
Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
McEachin J. J., 1993, AM J MENT RETARD, V97, P104
McPheeters ML, 2011, J AUTISM DEV DISORD, V41, P646, DOI 10.1007/s10803-010-1085-9
Mireault G, 2008, CHILD PSYCHIAT HUM D, V39, P519, DOI 10.1007/s10578-008-0106-9
O'Connor AB, 2010, RES AUTISM SPECT DIS, V4, P594, DOI 10.1016/j.rasd.2009.12.002
Ooi YP, 2011, AUST NZ J PSYCHIAT, V45, P370, DOI 10.3109/00048674.2010.534071
Park S, 2012, RES AUTISM SPECT DIS, V6, P1068, DOI 10.1016/j.rasd.2012.02.004
Rietz CS, 2012, DYSLEXIA, V18, P174, DOI 10.1002/dys.1442
Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
Sterba SK, 2007, DEV PSYCHOPATHOL, V19, P345, DOI 10.1017/S0954579407070174
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
Volker MA, 2010, J AUTISM DEV DISORD, V40, P188, DOI 10.1007/s10803-009-0849-6
Whitely P., 2003, CHILD CARE HEATH DEV, V30, P5
Zahn-Waxler C, 2000, DEV PSYCHOPATHOL, V12, P443, DOI 10.1017/S0954579400003102
NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1347
EP 1356
DI 10.1007/s10803-013-1995-4
PG 10
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400007
PM 24242972
ER
PT J
AU Towle, PO
Vacanti-Shova, K
Shah, S
Higgins-D'alessandro, A
AF Towle, Patricia O.
Vacanti-Shova, Karyn
Shah, Shristi
Higgins-D'alessandro, Ann
TI School-Aged Functioning of Children Diagnosed with Autism Spectrum
Disorder Before Age Three: Parent-Reported Diagnostic, Adaptive,
Medication, and School Placement Outcomes
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ASD; Early diagnosis; Longitudinal; School-age; School
placement; Adaptive behavior; Medication use
ID PERVASIVE DEVELOPMENTAL DISORDERS; FOLLOW-UP; INTERRATER RELIABILITY;
EARLY INTERVENTION; YOUNG-CHILDREN; EARLY IDENTIFICATION; PRESCHOOL
YEARS; DRUG-USE; STABILITY; SURVEILLANCE
AB Eighty children with early autism spectrum disorder (ASD) diagnoses (under 36 months) were identified using a chart abstraction protocol applied to early intervention charts. Parents filled out questionnaires by mail when the children were school-aged (ages 6-16 years). Similar to previous studies, approximately 20 % no longer had ASD diagnoses; the other participants were assigned to Moderate/Severe versus Mild ASD outcome groups. These three groups were compared across several variables, including diagnostic features and functional features including adaptive behavior, social experiences, medication use, and school placement. The findings expand our knowledge about outcomes in longitudinal studies of children with ASD, as well as provide support for using relatively indirect methods (chart review, parent questionnaire) to gather this type of information.
C1 [Towle, Patricia O.; Vacanti-Shova, Karyn; Shah, Shristi] Westchester Inst Human Dev, Valhalla, NY 10538 USA.
[Towle, Patricia O.] New York Med Coll, Sch Hlth Sci & Practice, Valhalla, NY 10595 USA.
[Vacanti-Shova, Karyn; Higgins-D'alessandro, Ann] Fordham Univ, Dept Psychol, Bronx, NY 10458 USA.
RP Towle, PO (reprint author), Westchester Inst Human Dev, Cedarwood Hall, Valhalla, NY 10538 USA.
EM ptowle@wihd.org
CR Akshoomoff N, 2010, J POSIT BEHAV INTERV, V12, P245, DOI 10.1177/1098300709343724
Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
Avchen RN, 2011, J AUTISM DEV DISORD, V41, P227, DOI 10.1007/s10803-010-1050-7
Centers for Disease Control and Prevention, 2007, MMWR SURVEILL SUMM, V56, P12
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
Cicchetti D, 2006, J NERV MENT DIS, V194, P557, DOI 10.1097/01.nmd.0000230392.83607.c5
CICCHETTI DV, 1981, AM J MENT DEF, V86, P127
CICCHETTI DV, 1981, EDUC PSYCHOL MEAS, V41, P189, DOI 10.1177/001316448104100119
Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488
Donner A., 1992, STAT MED, V11, P1151
Eaves LC, 2004, J AUTISM DEV DISORD, V34, P367, DOI 10.1023/B:JADD.0000037414.33270.a8
Eaves LC, 1997, J DEV PHYS DISABIL, V9, P277, DOI 10.1023/A:1024944226971
Fein D, 2005, J AUTISM DEV DISORD, V35, P525, DOI 10.1007/s10803-005-5066-3
Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037
FLEISS JL, 1981, APPL PSYCH MEAS, V5, P105, DOI 10.1177/014662168100500115
Fombonne E, 2002, MOL PSYCHIATR, V7, pS4, DOI 10.1038/sj.mp.4001162
GILLBERG C, 1990, J CHILD PSYCHOL PSYC, V31, P921, DOI 10.1111/j.1469-7610.1990.tb00834.x
Gilliam J. E., 1995, GILLIAM AUTISM RATIN
Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
Boyd BA, 2010, J EARLY INTERVENTION, V32, P75, DOI 10.1177/1053815110362690
Jonsdottir SL, 2007, J AUTISM DEV DISORD, V37, P1361, DOI 10.1007/s10803-006-0282-z
Kelley E, 2006, J AUTISM DEV DISORD, V36, P807, DOI 10.1007/s10803-006-0111-4
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P606, DOI 10.1007/s10803-007-0427-8
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Logan SL, 2012, ANN EPIDEMIOL, V22, P1, DOI 10.1016/j.annepidem.2011.10.007
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
Malhi P, 2011, INDIAN J PEDIATR, V78, P941, DOI 10.1007/s12098-011-0370-8
Martin A, 1999, J AM ACAD CHILD PSY, V38, P923, DOI 10.1097/00004583-199907000-00024
Michelotti J, 2002, DEV MED CHILD NEUROL, V44, P812
Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018
Moss J, 2008, J AUTISM DEV DISORD, V38, P1081, DOI 10.1007/s10803-007-0487-9
Rondeau E, 2011, J AUTISM DEV DISORD, V41, P1267, DOI 10.1007/s10803-010-1155-z
Rosenberg RE, 2011, AUTISM RES TREATMENT, P1, DOI DOI 10.1155/2011/405849
Rosner B., 1995, FUNDAMENTALS BIOSTAT, V4th
Scambler DJ, 2006, J DEV BEHAV PEDIATR, V27, pS104, DOI 10.1097/00004703-200604002-00008
Schopler E., 1988, CHILDHOOD AUTISM RAT
Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
Sparrow S, 1984, VINELAND ADAPTIVE BE
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370
Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
Szatmari P, 2000, AM J PSYCHIAT, V157, P1980, DOI 10.1176/appi.ajp.157.12.1980
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Towle PO, 2009, J AUTISM DEV DISORD, V39, P444, DOI 10.1007/s10803-008-0643-x
Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
Turner LM, 2006, AUTISM, V10, P243, DOI 10.1177/1362361306063296
van Daalen E, 2009, EUR CHILD ADOLES PSY, V18, P663, DOI 10.1007/s00787-009-0025-8
White SW, 2007, J AUTISM DEV DISORD, V37, P1403, DOI 10.1007/s10803-006-0281-0
Wiggins LD, 2013, AUTISM, V17, P623, DOI 10.1177/1362361312452161
Woolfenden S, 2012, RES AUTISM SPECT DIS, V6, P345, DOI 10.1016/j.rasd.2011.06.008
NR 58
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1357
EP 1372
DI 10.1007/s10803-013-1997-2
PG 16
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400008
PM 24346492
ER
PT J
AU Sawyer, ACP
Williamson, P
Young, R
AF Sawyer, Alyssa C. P.
Williamson, Paul
Young, Robyn
TI Metacognitive Processes in Emotion Recognition: Are They Different in
Adults with Asperger's Disorder?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger's Disorder; Emotion recognition; Metacognitive monitoring;
Social skill
ID AUTISM SPECTRUM DISORDERS; CHILDREN; MIND; INDIVIDUALS; METAMEMORY;
MEMORY; EXPRESSIONS; COMPETENCE; ACCURACY; DEFICITS
AB Deficits in emotion recognition and social interaction characterize individuals with Asperger's Disorder (AS). Moreover they also appear to be less able to accurately use confidence to gauge their emotion recognition accuracy (i.e., metacognitive monitoring). The aim of this study was to extend this finding by considering both monitoring and control processes in emotion recognition among adults with AS. Those with AS were found to have difficulties acting on the basis of their metacognitive monitoring despite showing no deficits in their ability to discriminate accurate from inaccurate decisions. It is suggested that adults with AS have difficulties interacting socially because they are less able to assess when they are making accurate emotion recognition decisions despite having the capability to do so.
C1 [Sawyer, Alyssa C. P.; Williamson, Paul; Young, Robyn] Flinders Univ South Australia, Sch Psychol, Adelaide, SA, Australia.
RP Sawyer, ACP (reprint author), Univ Adelaide, Sch Populat Hlth, Discipline Publ Hlth, 178 North Terrace,MDP DX 650 550, Adelaide, SA 5005, Australia.
EM alyssa.sawyer@adelaide.edu.au; paul.williamson@flinders.edu.au;
robyn.young@flinders.edu.au
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ames DR, 2004, J NONVERBAL BEHAV, V28, P187, DOI 10.1023/B:JONB.0000039649.20015.0e
Axelrod BN, 2002, ASSESSMENT, V9, P17, DOI 10.1177/1073191102009001003
BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
Baron-Cohen Simon, 1997, MINDBLINDNESS ESSAY
Beaupre MG, 2006, PERS SOC PSYCHOL B, V32, P16, DOI 10.1177/0146167205277097
Bebko J. M., 2000, AUTISM, V4, P299, DOI DOI 10.1177/1362361300004003006
Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
Denham SA, 2003, CHILD DEV, V74, P238, DOI 10.1111/1467-8624.00533
Farrant A, 1999, J AUTISM DEV DISORD, V29, P359, DOI 10.1023/A:1023074726548
Farrant A, 1999, CHILD DEV, V70, P107
Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x
Garcia-Villamisar D, 2010, RES AUTISM SPECT DIS, V4, P755, DOI 10.1016/j.rasd.2010.01.016
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Golan O, 2008, J AUTISM DEV DISORD, V38, P1534, DOI 10.1007/s10803-007-0533-7
Heerey EA, 2003, EMOTION, V3, P394, DOI 10.1037/1528-3542.3.4.394
Higham PA, 2009, J EXP PSYCHOL LEARN, V35, P57, DOI 10.1037/a0013865
Hobson R. P., 1993, UNDERSTANDING OTHER, P204
HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
Izard C, 2001, PSYCHOL SCI, V12, P18, DOI 10.1111/1467-9280.00304
Koriat A, 1996, PSYCHOL REV, V103, P490, DOI 10.1037/0033-295X.103.3.490
Lockl K, 2007, CHILD DEV, V78, P148, DOI 10.1111/j.1467-8624.2007.00990.x
Lovibond SH, 1995, MANUAL DEPRESSION AN
Nagesh A., 2009, AS PAC AUT C
Nelson TO, 2004, PSYCHOL METHODS, V9, P53, DOI 10.1037/1082-989X.9.1.53
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
Patterson ML, 2001, J NONVERBAL BEHAV, V25, P207, DOI 10.1023/A:1010675210696
Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
Sawyer ACP, 2012, J AUTISM DEV DISORD, V42, P606, DOI 10.1007/s10803-011-1283-0
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
SMITH HJ, 1991, J NONVERBAL BEHAV, V15, P3, DOI 10.1007/BF00997764
Tabachnick B.G., 1996, USING MULTIVARIATE S, V2nd
Wallace S, 2008, COGNITION EMOTION, V22, P1353, DOI 10.1080/02699930701782153
Wilkinson DA, 2010, J AUTISM DEV DISORD, V40, P1371, DOI 10.1007/s10803-010-0995-x
Wojcik DZ, 2013, NEUROPSYCHOLOGY, V27, P19, DOI 10.1037/a0030526
NR 37
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1373
EP 1382
DI 10.1007/s10803-013-1999-0
PG 10
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400009
PM 24272525
ER
PT J
AU Huang, CY
Yen, HC
Tseng, MH
Tung, LC
Chen, YD
Chen, KL
AF Huang, Chien-Yu
Yen, Hsui-Chen
Tseng, Mei-Hui
Tung, Li-Chen
Chen, Ying-Dar
Chen, Kuan-Lin
TI Impacts of Autistic Behaviors, Emotional and Behavioral Problems on
Parenting Stress in Caregivers of Children with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autistic behaviors; Emotional and behavioral problems; Parenting stress;
Autism
ID RATING-SCALE CARS; SPECTRUM DISORDERS; CHILDHOOD AUTISM;
PRESCHOOL-CHILDREN; MOTHERS; FATHERS; ASSOCIATIONS; TODDLERS
AB This study examined the effects of autistic behaviors and individual emotional and behavioral problems on parenting stress in caregivers of children with autism. Caregivers were interviewed with the Childhood Autism Rating Scale and completed the Strength and Difficulties Questionnaire and the Parenting Stress Index Short Form. Results revealed that caregivers of children with mild/moderate autistic behavior problems perceived lower parenting stress than did those of children with no or severe problems. In addition, prosocial behaviors and conduct problems respectively predicted stress in the parent-child relationship and child-related stress. The findings can provide guidance in evaluations and interventions with a focus on mitigating parenting stress in caregivers of children with autism.
C1 [Huang, Chien-Yu; Tseng, Mei-Hui] Natl Taiwan Univ, Coll Med, Sch Occupat Therapy, Taipei 100, Taiwan.
[Yen, Hsui-Chen; Tung, Li-Chen] Chi Mei Med Ctr, Dept Phys Med & Rehabil, Tainan 710, Taiwan.
[Tseng, Mei-Hui; Chen, Kuan-Lin] Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
[Chen, Ying-Dar] Country Hosp, Dept Phys Med & Rehabil, Taipei 106, Taiwan.
[Chen, Kuan-Lin] Natl Cheng Kung Univ, Coll Med, Sch Occupat Therapy, Tainan 701, Taiwan.
RP Chen, KL (reprint author), Natl Cheng Kung Univ, Coll Med, Sch Occupat Therapy, 1 Univ Rd, Tainan 701, Taiwan.
EM klchen@mail.ncku.edu.tw
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Chlebowski C, 2010, J AUTISM DEV DISORD, V40, P787, DOI 10.1007/s10803-009-0926-x
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
DILALLA DL, 1994, J AUTISM DEV DISORD, V24, P115, DOI 10.1007/BF02172092
Du Yasong, 2008, Child Adolesc Psychiatry Ment Health, V2, P8, DOI 10.1186/1753-2000-2-8
Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
EAVES RC, 1993, J ABNORM CHILD PSYCH, V21, P481, DOI 10.1007/BF00916315
Estes A, 2013, BRAIN DEV-JPN, V35, P133, DOI 10.1016/j.braindev.2012.10.004
Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
Hastings R. P., 2002, J INFORM, V107
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
King G, 2005, INT J DISABIL DEV ED, V52, P313, DOI DOI 10.1080/10349120500348680
KONSTANTAREAS MM, 1989, J CHILD PSYCHOL PSYC, V30, P459, DOI 10.1111/j.1469-7610.1989.tb00259.x
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Mayes SD, 2009, J AUTISM DEV DISORD, V39, P1682, DOI 10.1007/s10803-009-0812-6
Mayes SD, 2012, FOCUS AUTISM DEV DIS, V27, P31, DOI 10.1177/1088357611406902
McMahon R. J., 1998, CONDUCT PROBLEMS
Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
Phetrasuwan S, 2009, J SPEC PEDIATR NURS, V14, P157, DOI 10.1111/j.1744-6155.2009.00188.x
Schopler E., 1988, CHILDHOOD AUTISM RAT
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Walsh CE, 2013, RES AUTISM SPECT DIS, V7, P256, DOI 10.1016/j.rasd.2012.08.010
Wang J, 2013, SOC PSYCH PSYCH EPID, V48, P575, DOI 10.1007/s00127-012-0569-7
Wen B., 2003, PARENTING STRESS IND
Windle M, 1996, J ABNORM PSYCHOL, V105, P551, DOI 10.1037/0021-843X.105.4.551
World Health Organization, 1992, INT STAT CLASSIFICAT
Yeh CH, 2001, ACTA PAEDIATR, V90, P1470
NR 28
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1383
EP 1390
DI 10.1007/s10803-013-2000-y
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400010
PM 24287878
ER
PT J
AU Boulter, C
Freeston, M
South, M
Rodgers, J
AF Boulter, Christina
Freeston, Mark
South, Mikle
Rodgers, Jacqui
TI Intolerance of Uncertainty as a Framework for Understanding Anxiety in
Children and Adolescents with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorders; Anxiety; Intolerance of Uncertainty;
Children; Adolescents
ID OBSESSIVE-COMPULSIVE DISORDER; COGNITIVE-BEHAVIORAL TREATMENT;
GENERALIZED ANXIETY; PSYCHOMETRIC PROPERTIES; EXPERIMENTAL MANIPULATION;
PSYCHOLOGICAL-RESEARCH; REPETITIVE BEHAVIOR; PROBLEM ORIENTATION;
SOCIAL-ANXIETY; WORRY
AB Anxiety is a problem for many children diagnosed with Autism Spectrum Disorders (ASDs). There is a paucity of models of the cognitive processes underlying this. Intolerance of Uncertainty (IU) has utility in explaining anxiety in neurotypical populations but has only recently received attention in ASD. We modelled the relationship between anxiety and IU in ASD and a typically developing comparison group, using parent and child self-report measures. Results confirmed significant relationships between IU and anxiety in children with ASD which appears to function similarly in children with and without ASD. Results were consistent with a causal model suggesting that IU mediates the relationship between ASD and anxiety. The findings confirm IU as a relevant construct in ASD.
C1 [Boulter, Christina] Newcastle Univ, Sch Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Boulter, Christina; Freeston, Mark] Northumberland Tyne & Wear NHS Trust, Newcastle Upon Tyne NE3 3XT, Tyne & Wear, England.
[Freeston, Mark; Rodgers, Jacqui] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[South, Mikle] Brigham Young Univ, Dept Psychol & Neurosci, Provo, UT 84602 USA.
RP Rodgers, J (reprint author), Newcastle Univ, Inst Neurosci, Ridley Bldg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
EM Jacqui.rodgers@ncl.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, APA DSM 5
Barbosa J, 2002, DEPRESS ANXIETY, V15, P61, DOI 10.1002/da.10022
BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
Berenbaum H, 2008, J ANXIETY DISORD, V22, P117, DOI 10.1016/j.janxdis.2007.01.004
Birrell J, 2011, CLIN PSYCHOL REV, V31, P1198, DOI 10.1016/j.cpr.2011.07.009
Boelen PA, 2009, J ANXIETY DISORD, V23, P130, DOI 10.1016/j.janxdis.2008.04.007
Boelen PA, 2010, J NERV MENT DIS, V198, P194, DOI 10.1097/NMD.0b013e3181d143de
Boswell JF, 2013, J CLIN PSYCHOL, V69, P630, DOI 10.1002/jclp.21965
Bredemeier K, 2008, BEHAV RES THER, V46, P28, DOI 10.1016/j.brat.2007.09.006
Buhr K, 2012, INT J COGN THER, V5, P1
Buhr K, 2002, BEHAV RES THER, V40, P931, DOI 10.1016/S0005-7967(01)00092-4
Buhr K, 2009, BEHAV RES THER, V47, P215, DOI 10.1016/j.brat.2008.12.004
Buhr K, 2006, J ANXIETY DISORD, V20, P222, DOI 10.1016/j.janxdis.2004.12.004
Carleton RN, 2007, BEHAV RES THER, V45, P2307, DOI 10.1016/j.brat.2007.04.006
Carleton RN, 2010, J ANXIETY DISORD, V24, P189, DOI 10.1016/j.janxdis.2009.10.007
Carleton RN, 2012, J ANXIETY DISORD, V26, P150, DOI 10.1016/j.janxdis.2011.10.006
Carleton RN, 2007, J ANXIETY DISORD, V21, P105, DOI 10.1016/j.janxdis.2006.03.014
Carleton RN, 2012, J ANXIETY DISORD, V26, P468, DOI 10.1016/j.janxdis.2012.01.011
Carleton RN, 2012, EXPERT REV NEUROTHER, V12, P937, DOI 10.1586/ERN.12.82
Chamberlain PD, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-31
Choudhury MS, 2003, J AM ACAD CHILD PSY, V42, P957, DOI 10.1097/01.CHI.0000046898.27264.A2
Comer JS, 2009, PSYCHOL ASSESSMENT, V21, P402, DOI 10.1037/a0016719
Constantino JN, 2002, SOCIAL RESPONSIVENES
De Los Reyes A, 2011, J CLIN CHILD ADOLESC, V40, P36, DOI 10.1080/15374416.2011.533402
Dugas MJ, 2000, BEHAV MODIF, V24, P635, DOI 10.1177/0145445500245002
Dugas MJ, 2005, J ANXIETY DISORD, V19, P329, DOI 10.1016/j.janxdis.2004.02.002
Dugas MJ, 2003, J CONSULT CLIN PSYCH, V71, P821, DOI 10.1037/0022-006X.71.4.821
Dugas Michel J., 2009, Cognitive Behaviour Therapy, V38, P29, DOI [10.1080/16506070902980745, 10.1080/16506070802473221]
Dugas MJ, 1997, COGNITIVE THER RES, V21, P593, DOI 10.1023/A:1021890322153
Dugas MJ, 1998, BEHAV RES THER, V36, P215, DOI 10.1016/S0005-7967(97)00070-3
Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
Fialko L, 2012, BEHAV RES THER, V50, P341, DOI 10.1016/j.brat.2012.02.003
FREESTON MH, 1994, PERS INDIV DIFFER, V17, P791, DOI 10.1016/0191-8869(94)90048-5
Gentes EL, 2011, CLIN PSYCHOL REV, V31, P923, DOI 10.1016/j.cpr.2011.05.001
Glod M., FACTOR STRUCTURE MEA
Grayson J. B., 2010, J COGNITIVE PSYCHOTH, V24, P3, DOI DOI 10.1891/0889-8391.24.1.3
Grupe DW, 2013, NAT REV NEUROSCI, V14, P488, DOI 10.1038/nrn3524
Holaway RM, 2006, J ANXIETY DISORD, V20, P158, DOI 10.1016/j.janxdis.2005.01.002
Jamieson R., 2011, THESIS NEWCASTLE U
Joosten AV, 2009, J AUTISM DEV DISORD, V39, P521, DOI 10.1007/s10803-008-0654-7
Kanner L, 1943, NERV CHILD, V2, P217
Kenny D. A., 2012, MEDIATION
Kertz S, 2013, BEHAV COGN PSYCHOTH, V41, P243, DOI 10.1017/S1352465812000641
Ladouceur R, 2000, BEHAV RES THER, V38, P933, DOI 10.1016/S0005-7967(99)00133-3
Ladouceur R, 2000, J CONSULT CLIN PSYCH, V68, P957, DOI 10.1037/0022-006X.68.6.957
Laugesen N, 2003, J ABNORM CHILD PSYCH, V31, P55, DOI 10.1023/A:1021721332181
Le Couteur A. S., 2003, NATL AUTISM PLAN CHI
Leekam SR, 2011, PSYCHOL BULL, V137, P562, DOI 10.1037/a0023341
Leger E, 2003, J AM ACAD CHILD PSY, V42, P327, DOI 10.1097/01.CHI.0000037034.04952.B1
Lopata C, 2010, J ABNORM CHILD PSYCH, V38, P765, DOI 10.1007/s10802-010-9406-1
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
McConachie H, 2009, ARCH DIS CHILD, V94, P38, DOI 10.1136/adc.2007.126326
McEvoy PM, 2012, BEHAV THER, V43, P533, DOI 10.1016/j.beth.2011.02.007
McEvoy PM, 2011, J ANXIETY DISORD, V25, P112, DOI 10.1016/j.janxdis.2010.08.010
Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
Payne S, 2011, COGNITIVE THER RES, V35, P171, DOI 10.1007/s10608-010-9341-z
Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x
Rodgers J., 2012, BRIT ASS BEH COGN PS
Rodgers J., 2013, INT M AUT RES SEB SP
Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
Scheurich A, 2010, Z KINDER JUG-PSYCH, V38, P103, DOI [10.1024/1422-4917.a000017, 10.1024/1422-4917/a000017]
Sookman D, 2002, COGNITIVE APPROACHES TO OBSESSIONS AND COMPULSIONS: THEORY, ASSESSMENT, AND TREATMENT, P63, DOI 10.1016/B978-008043410-0/50006-4
Spence SH, 2003, J ANXIETY DISORD, V17, P605, DOI 10.1016/S0887-6185(02)00236-0
Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
Storch EA, 2012, J CHILD ADOL PSYCHOP, V22, P292, DOI 10.1089/cap.2011.0114
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Tolin DF, 2003, J ANXIETY DISORD, V17, P233, DOI 10.1016/S0887-6185(02)00182-2
Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
Walker S., 2009, THESIS NEWASTLE U
Warner R. M., 2013, APPL STAT BIVARIATE
Wechsler D, 1999, WECHSLER ABBREVIATED
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
White SW, 2012, J AUTISM DEV DISORD, V42, P1138, DOI 10.1007/s10803-011-1353-3
Wilkinson A., 2011, CBT WORRY GENERALISE
Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 78
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1391
EP 1402
DI 10.1007/s10803-013-2001-x
PG 12
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400011
PM 24272526
ER
PT J
AU Myers, CL
Gross, AD
McReynolds, BM
AF Myers, Carl L.
Gross, Amber D.
McReynolds, Brandy M.
TI Broadband Behavior Rating Scales as Screeners for Autism?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Behavior rating scales; Early childhood
ID DIAGNOSTIC INTERVIEW; SPECTRUM DISORDERS; CHILDREN; IDENTIFICATION;
CBCL; PRESCHOOLERS; CHECKLIST; SCORES
AB In order to start providing important early intervention services to preschoolers and toddlers with autism, those children first need to be identified. Despite the availability of specialized autism assessment instruments, there is a need for effective screeners at the early childhood level. Three broadband behavior rating scales were evaluated in this study to determine if any of the scales on the instruments could adequately distinguish between children with autism from other clinically referred children. There were four scales from two instruments that resulted in mean scores outside the average range and had statistically significant differences. However, the small mean score differences and analyses of sensitivity and specificity suggest those scales have limited practical usefulness when used by clinicians.
C1 [Myers, Carl L.; Gross, Amber D.; McReynolds, Brandy M.] Western Kentucky Univ, Dept Psychol, Bowling Green, KY 42101 USA.
RP Myers, CL (reprint author), Western Kentucky Univ, Dept Psychol, 1906 Coll Hts Blvd 21030, Bowling Green, KY 42101 USA.
EM carl.myers@wku.edu
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Achenbach TM, 1991, MANUAL CHILD BEHAV C
Biederman J, 2010, J DEV BEHAV PEDIATR, V31, P485, DOI 10.1097/DBP.0b013e3181e56ddd
Bracken B. A., 2004, CLIN ASSESSMENT BEHA
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Chafouleas S. M., 2007, SCH BASED BEHAV ASSE
Charman T., 2003, EARLY CHILD DEV CARE, V173, P363, DOI 10.1080/0300443032000079050
Cicchetti DV, 1995, CHILD NEUROPSYCHOL, V1, P26, DOI 10.1080/09297049508401340
COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Coonrod E. E., 2005, HDB AUTISM PERVASIVE, V2, P707
Corsello C., 2005, HDB AUTISM PERVASIVE, V2, P730
Duarte CS, 2003, J AUTISM DEV DISORD, V33, P703, DOI 10.1023/B:JADD.0000006005.31818.1c
Goldstein S., 2010, AUTISM SPECTRUM RATI
Hass MR, 2012, REM SPEC EDUC, V33, P173, DOI 10.1177/0741932510383160
Kamp-Becker I, 2013, AUTISM, V17, P87, DOI 10.1177/1362361311408932
Lord C., 2012, AUTISM DIAGNOSTIC 1
Lord C, 1998, MENT RETARD DEV D R, V4, P90, DOI 10.1002/(SICI)1098-2779(1998)4:2<90::AID-MRDD5>3.0.CO;2-0
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lovaas O. I., 2003, TEACHING INDIVIDUALS
Mazefsky CA, 2011, J PSYCHOPATHOL BEHAV, V33, P31, DOI 10.1007/s10862-010-9198-1
McConachie H, 2005, J AUTISM DEV DISORD, V35, P167, DOI 10.1007/s10803-005-1995-0
Merrell K. W., 2008, BEHAV SOCIAL EMOTION, V3rd
Muratori F, 2011, EPIDEMIOL PSYCH SCI, V20, P329, DOI 10.1017/S204579601100045X
Myers CL, 2010, PSYCHOL SCHOOLS, V47, P205, DOI 10.1002/pits.20465
Myers CL, 2013, PSYCHOL SCHOOLS, V50, P1, DOI 10.1002/pits.21657
National Research Council, 2001, ED CHILDR AUT
Ooi YP, 2011, J AUTISM DEV DISORD, V41, P1147, DOI 10.1007/s10803-010-1015-x
Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Shapiro ES, 2004, PSYCHOL SCHOOLS, V41, P551, DOI 10.1002/pits.10176
Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
Sikora DM, 2008, J AUTISM DEV DISORD, V38, P440, DOI 10.1007/s10803-007-0407-z
South M, 2002, J AUTISM DEV DISORD, V32, P593, DOI 10.1023/A:1021211232023
Strik JJMH, 2001, PSYCHOSOMATICS, V42, P423, DOI 10.1176/appi.psy.42.5.423
U.S. Department of Education, 2011, 30 ANN C IMPL IND DI
Wiggins L., 2006, J DEV BEHAV PEDIATR, V27, P79, DOI DOI 10.1097/00004703-200604002-00005
Wilkinson LA, 2010, REM SPEC EDUC, V31, P350, DOI 10.1177/0741932509338372
NR 40
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1403
EP 1413
DI 10.1007/s10803-013-2004-7
PG 11
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400012
PM 24287879
ER
PT J
AU Gangi, DN
Ibanez, LV
Messinger, DS
AF Gangi, Devon N.
Ibanez, Lisa V.
Messinger, Daniel S.
TI Joint Attention Initiation With and Without Positive Affect: Risk Group
Differences and Associations with ASD Symptoms
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Anticipatory smiling; High-risk siblings; Autism spectrum disorders;
Initiating joint attention
ID AUTISM SPECTRUM DISORDERS; NONVERBAL-COMMUNICATION;
LANGUAGE-DEVELOPMENT; UNAFFECTED SIBLINGS; INFANT INTERACTION; SMILE
PRODUCTION; MOTHER-INFANT; DOWN-SYNDROME; CHILDREN; ENGAGEMENT
AB Infants at risk for autism spectrum disorders (ASD) may have difficulty integrating smiles into initiating joint attention (IJA) bids. A specific IJA pattern, anticipatory smiling, may communicate preexisting positive affect when an infant smiles at an object and then turns the smile toward the social partner. We compared the development of anticipatory smiling at 8, 10, and 12 months in infant siblings of children with ASD (high-risk siblings) and without ASD (low-risk siblings). High-risk siblings produced less anticipatory smiling than low-risk siblings, suggesting early differences in communicating preexisting positive affect. While early anticipatory smiling distinguished the risk groups, IJA not accompanied by smiling best predicted later severity of ASD-related behavioral characteristics among high-risk siblings. High-risk infants appear to show lower levels of motivation to share positive affect with others. However, facility with initiating joint attention in the absence of a clear index of positive affective motivation appears to be central to the prediction of ASD symptoms.
C1 [Gangi, Devon N.] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA.
[Ibanez, Lisa V.] Univ Washington, Dept Psychol, Autism Ctr, Seattle, WA 98195 USA.
[Messinger, Daniel S.] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA.
[Messinger, Daniel S.] Univ Miami, Dept Pediat, Coral Gables, FL 33146 USA.
[Messinger, Daniel S.] Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33146 USA.
RP Gangi, DN (reprint author), Univ Miami, Dept Psychol, 5665 Ponce de Leon Blvd, Coral Gables, FL 33146 USA.
EM devon.gangi@gmail.com
CR Adamson LB, 2009, J AUTISM DEV DISORD, V39, P84, DOI 10.1007/s10803-008-0601-7
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
BAKEMAN R, 1984, CHILD DEV, V55, P1278, DOI 10.2307/1129997
Bedford R, 2012, J AUTISM DEV DISORD, V42, P2208, DOI 10.1007/s10803-012-1450-y
Beriner R., 2011, AUTISM RES TREATMENT, DOI [10.1155/2011/545901, DOI 10.1155/2011/545901]
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
BLOOM L, 1987, CHILD DEV, V58, P1513, DOI 10.2307/1130691
BLOOM L, 1988, INFANT BEHAV DEV, V11, P169, DOI 10.1016/S0163-6383(88)80004-3
Cassel TD, 2007, J AUTISM DEV DISORD, V37, P122, DOI 10.1007/s10803-006-0337-1
Damiano CR, 2013, J AUTISM DEV DISORD, V43, P1326, DOI 10.1007/s10803-012-1681-y
DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Ekman P., 1978, FACIAL ACTION CODING
Georgiades S, 2013, JAMA PSYCHIAT, V70, P42, DOI 10.1001/2013.jamapsychiatry.1
Goldberg WA, 2005, J AUTISM DEV DISORD, V35, P657, DOI 10.1007/s10803-005-0009-6
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Ibanez LV, 2013, INFANCY, V18, P687, DOI 10.1111/j.1532-7078.2012.00142.x
JONES SS, 1989, CHILD DEV, V60, P811, DOI 10.1111/j.1467-8624.1989.tb03512.x
Jones SS, 2001, INFANCY, V2, P353, DOI 10.1207/S15327078IN0203_4
JONES SS, 1991, PSYCHOL SCI, V2, P45, DOI 10.1111/j.1467-9280.1991.tb00095.x
Jones SS, 2005, INFANT BEHAV DEV, V28, P194, DOI 10.1016/j.infbeh.2005.02.003
Joseph RM, 1997, J AUTISM DEV DISORD, V27, P385, DOI 10.1023/A:1025853321118
KASARI C, 1990, J AUTISM DEV DISORD, V20, P87, DOI 10.1007/BF02206859
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Messinger DS, 1998, MERRILL PALMER QUART, V44, P566
Mullen E, 1995, MULLEN SCALES EARLY
Mundy P., 2001, ASSESSMENT EFFECTIVE, V27, P57, DOI 10.1177/073724770202700108
Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
Mundy P., 2003, MANUAL ABRIDGED EARL
Nichols CM, 2014, J AUTISM DEV DISORD, V44, P894, DOI 10.1007/s10803-013-1944-2
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Parlade MV, 2009, INFANT BEHAV DEV, V32, P33, DOI 10.1016/j.infbeh.2008.09.007
Presmanes AG, 2007, J AUTISM DEV DISORD, V37, P133, DOI 10.1007/s10803-006-0338-0
Raudenbush S., 2004, HLM 6 HIERARCHICAL L
Raudenbush S. W., 2002, HIERARCHICAL LINEAR, V2nd
Rozga A, 2011, J AUTISM DEV DISORD, V41, P287, DOI 10.1007/s10803-010-1051-6
Singer J. D., 2003, APPL LONGITUDINAL DA
Tierney AL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039127
Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
Venezia M, 2004, INFANCY, V6, P397, DOI 10.1207/s15327078in0603_5
Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x
Yoder P, 2009, J AUTISM DEV DISORD, V39, P1381, DOI 10.1007/s10803-009-0753-0
Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
NR 47
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1414
EP 1424
DI 10.1007/s10803-013-2002-9
PG 11
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400013
PM 24281421
ER
PT J
AU Peters, B
Williams, KC
Gorrindo, P
Rosenberg, D
Lee, EB
Levitt, P
Veenstra-VanderWeele, J
AF Peters, Brittany
Williams, Kent C.
Gorrindo, Phillip
Rosenberg, Daniel
Lee, Evon Batey
Levitt, Pat
Veenstra-VanderWeele, Jeremy
TI Rigid-Compulsive Behaviors are Associated with Mixed Bowel Symptoms in
Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Repetitive behavior; Constipation; Encopresis
ID FUNCTIONAL GASTROINTESTINAL DISORDERS; PERVASIVE DEVELOPMENTAL
DISORDERS; SEROTONIN TRANSPORTER; UNITED-STATES; CHILDREN; PREVALENCE;
FAMILIES; INSIGHTS; FEATURES
AB Based on clinical experience, we hypothesized that rigid-compulsive behaviors are associated with severe constipation and co-occurring diarrhea or underwear staining in children with autism spectrum disorder. Using data from the Autism Treatment Network, we evaluated the association between these gastrointestinal symptoms and measures of rigid compulsive behavior in children ages 2-17. Following statistical correction, four of five primary measures were significantly associated with constipation and diarrhea or underwear staining, including parental report of repetitive behavior, parental report of compulsive behavior, clinician diagnosis of obsessive-compulsive disorder, and report of rituals observed on the autism diagnostic observation schedule. This association could point to a causal connection between these symptoms or to a common biological pathway that impacts both gut and brain.
C1 [Peters, Brittany; Gorrindo, Phillip; Lee, Evon Batey; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Nashville, TN 37212 USA.
[Williams, Kent C.] Nationwide Childrens Hosp, Columbus, OH USA.
[Rosenberg, Daniel] EMMES Corp, Rockville, MD USA.
[Levitt, Pat] Univ So Calif, Los Angeles, CA USA.
RP Peters, B (reprint author), Vanderbilt Univ, 1601 23rd Ave South,Suite 300, Nashville, TN 37212 USA.
EM brittany.peters@vanderbilt.edu
CR Adams J., 2011, BMC GASTROLOGY, V11
Afzal N, 2003, PEDIATRICS, V112, P939, DOI 10.1542/peds.112.4.939
Ando H., 1977, AUTISM CHILDHOOD SCH, V7, P151
[Anonymous], 2012, WHAT ATN
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Bayley N, 2006, BAYLEY SCALES INFANT, V3rd
Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419
Brazzelli M, 2011, COCHRANE DB SYST REV, V12
Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819
Chen JJ, 2001, J NEUROSCI, V21, P6348
Di Lorenzo C, 2004, GASTROENTEROLOGY, V126, pS33, DOI 10.1053/j.gastro.2003.10.012
Ford AC, 2009, AM J GASTROENTEROL, V104, P1831, DOI 10.1038/ajg.2009.223
Frances A., 2000, DIAGNOSTIC STAT MANU
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Gershon MD, 2013, CURR OPIN ENDOCRINOL, V20, P14, DOI 10.1097/MED.0b013e32835bc703
Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
Gorrindo P., 2006, GASTROENTEROLOGY, V130, P1447
Hyman PE, 2006, GASTROENTEROLOGY, V130, P1519, DOI 10.1053/j.gastro.2005.11.065
Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
Lesch KP, 2012, PHILOS T R SOC B, V367, P2426, DOI 10.1098/rstb.2012.0039
Maenner MJ, 2012, J AUTISM DEV DISORD, V42, P1520, DOI 10.1007/s10803-011-1379-6
Masand PS, 2006, CNS SPECTRUMS, V11, P21
Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
Molloy CA, 2003, AUTISM, V7, P165, DOI 10.1177/1362361303007002004
Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0
Mullen E, 1995, MULLEN SCALES EARLY
Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934
Murphy DL, 2008, NAT REV NEUROSCI, V9, P85, DOI 10.1038/nrn2284
Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8
North C S, 1995, Ann Clin Psychiatry, V7, P65, DOI 10.3109/10401239509149029
Rasquin A, 2006, GASTROENTEROLOGY, V130, P1527, DOI 10.1053/j.gastro.2005.08.063
Roid G., 1997, LEITER INT PERFORMAN
Roid G. H., 2003, STANFORD BINET INTEL
Ruepert L., 2011, COCHRANE DATABASE SY, V10
Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
Valicenti-McDermott MD, 2008, PEDIATR NEUROL, V39, P392, DOI 10.1016/j.pediatrneurol.2008.07.019
Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185
Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a
NR 39
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1425
EP 1432
DI 10.1007/s10803-013-2009-2
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400014
PM 24293040
ER
PT J
AU David, N
Schultz, J
Milne, E
Schunke, O
Schottle, D
Munchau, A
Siegel, M
Vogeley, K
Engel, AK
AF David, Nicole
Schultz, Johannes
Milne, Elizabeth
Schunke, Odette
Schoettle, Daniel
Muenchau, Alexander
Siegel, Markus
Vogeley, Kai
Engel, Andreas K.
TI Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception
in the Autism Spectrum
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Asperger syndrome; Motion coherence; Animacy; Social perception;
Voxel-based morphometry
ID VOXEL-BASED MORPHOMETRY; TEMPORO-PARIETAL JUNCTION; BIOLOGICAL MOTION;
FUNCTIONING AUTISM; VISUAL-PERCEPTION; ANIMATED SHAPES; BRAIN STRUCTURE;
MENTAL STATES; NETWORK SIZE; DISORDERS
AB Individuals with an autism spectrum disorder (ASD) show hallmark deficits in social perception. These difficulties might also reflect fundamental deficits in integrating visual signals. We contrasted predictions of a social perception and a spatial-temporal integration deficit account. Participants with ASD and matched controls performed two tasks: the first required spatiotemporal integration of global motion signals without social meaning, the second required processing of socially relevant local motion. The ASD group only showed differences to controls in social motion evaluation. In addition, gray matter volume in the temporal-parietal junction correlated positively with accuracy in social motion perception in the ASD group. Our findings suggest that social-perceptual difficulties in ASD cannot be reduced to deficits in spatial-temporal integration.
C1 [David, Nicole; Engel, Andreas K.] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, D-20246 Hamburg, Germany.
[Schultz, Johannes] Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany.
[Milne, Elizabeth] Univ Sheffield, Dept Psychol, Sheffield S10 2TN, S Yorkshire, England.
[Schunke, Odette; Muenchau, Alexander] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, D-20246 Hamburg, Germany.
[Schoettle, Daniel] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany.
[Siegel, Markus] Univ Tubingen, Ctr Integrat Neurosci, Tubingen, Germany.
[Vogeley, Kai] Univ Cologne, Dept Psychiat & Psychotherapy, D-50931 Cologne, Germany.
[Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med INM3, Cognit Neurol Sect, Julich, Germany.
RP David, N (reprint author), Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, Martinistr 52, D-20246 Hamburg, Germany.
EM ndavid@uke.de; j.w.r.schultz@durham.ac.uk
RI David, Nicole/H-1682-2012
CR Abell F, 1999, NEUROREPORT, V10, P1647, DOI 10.1097/00001756-199906030-00005
Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x
Ashburner J, 2000, NEUROIMAGE, V11, P805, DOI 10.1006/nimg.2000.0582
Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Bastiaansen JA, 2011, J AUTISM DEV DISORD, V41, P1256, DOI 10.1007/s10803-010-1157-x
Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
Bickart KC, 2011, NAT NEUROSCI, V14, P163, DOI 10.1038/nn.2724
Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
Blanke O, 2005, NEUROSCIENTIST, V11, P16, DOI 10.1177/1073858404270885
Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016
Brambilla P, 2003, BIOL PSYCHIAT, V54, P1294, DOI 10.1016/S0006-3223(03)00070-2
Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x
Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x
Button KS, 2013, NAT REV NEUROSCI, V14, P365, DOI 10.1038/nrn3475
Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Cheverud JM, 2001, HEREDITY, V87, P52, DOI 10.1046/j.1365-2540.2001.00901.x
Congiu S, 2010, J AUTISM DEV DISORD, V40, P39, DOI 10.1007/s10803-009-0824-2
Corbetta M, 2000, NAT NEUROSCI, V3, P292, DOI 10.1038/73009
CORBETTA M, 1991, J NEUROSCI, V11, P2383
COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Decety J, 2007, NEUROSCIENTIST, V13, P580, DOI 10.1177/1073858407304654
de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65
Del Viva MM, 2006, VISION RES, V46, P1242, DOI 10.1016/j.visres.2005.10.018
den Ouden HEM, 2005, NEUROIMAGE, V28, P787, DOI 10.1016/j.neuroimage.2005.05.001
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Duvernoy H., 1999, HUMAN BRAIN
Dziobek I, 2010, ARCH GEN PSYCHIAT, V67, P397, DOI 10.1001/archgenpsychiatry.2010.31
Eickhoff SB, 2005, NEUROIMAGE, V25, P1325, DOI 10.1016/j.neuroimage.2004.12.034
Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692
Goldstein G, 2001, J AUTISM DEV DISORD, V31, P433, DOI 10.1023/A:1010620820786
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378
Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209
Kanai R, 2012, P ROY SOC B-BIOL SCI, V279, P1327, DOI 10.1098/rspb.2011.1959
Kanai R, 2012, CURR BIOL, V22, P1975, DOI 10.1016/j.cub.2012.08.045
Kanai R, 2011, NAT REV NEUROSCI, V12, P231, DOI 10.1038/nrn3000
Ke XY, 2009, BRAIN RES, V1265, P171, DOI 10.1016/j.brainres.2009.02.013
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Klin A, 2006, BRAIN COGNITION, V61, P40, DOI 10.1016/j.bandc.2005.12.016
Koldewyn K, 2011, DEVELOPMENTAL SCI, V14, P1075, DOI 10.1111/j.1467-7687.2011.01058.x
Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272
Kosaka H, 2010, NEUROIMAGE, V50, P1357, DOI 10.1016/j.neuroimage.2010.01.085
Lai G, 2012, BRAIN, V135, P961, DOI 10.1093/brain/awr335
Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
Lehrl S, 1995, MEHRFACHWAHL WORTSCH
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luks TL, 2004, NEUROIMAGE, V22, P1515, DOI 10.1016/j.neuroimage.2004.04.008
Mars RB, 2011, CEREB CORTEX, V22, P1894, DOI [DOI 10.1093/CERCOR/BHR268, 10.1093/cercor/bhr268]
Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018
Milne E., 2007, BRIT IRISH ORTHOPTIC, V4, P15
Milne E, 2006, J AUTISM DEV DISORD, V36, P225, DOI 10.1007/s10803-005-0052-3
Molenberghs Pascal, 2012, Neurosci Biobehav Rev, V36, P341, DOI 10.1016/j.neubiorev.2011.07.004
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Nickl-Jockschat T, 2011, HUM BRAIN MAPP, V33, P1470
Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Oostenveld R, 2011, COMPUT INTEL NEUROSC, DOI 10.1155/2011/156869
Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520
Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
REITAN R. M., 1958, PERCEPT MOT SKILLS, V8, P271
Riva D, 2011, AM J NEURORADIOL, V32, P1430, DOI 10.3174/ajnr.A2527
Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
Sallet J, 2011, SCIENCE, V334, P697, DOI 10.1126/science.1210027
Salmond CH, 2007, CORTEX, V43, P686, DOI 10.1016/S0010-9452(08)70498-2
Salmond CH, 2005, EUR J NEUROSCI, V22, P764, DOI 10.1111/j.1460-9568.2005.04217.x
Sanchez-Cubillo I, 2009, J INT NEUROPSYCH SOC, V15, P438, DOI 10.1017/S1355617709090626
Sanchez-Marin FJ, 2008, J AUTISM DEV DISORD, V38, P1270, DOI 10.1007/s10803-007-0507-9
Santiesteban I, 2012, CURR BIOL, V22, P2274, DOI 10.1016/j.cub.2012.10.018
Saxe R, 2006, CURR OPIN NEUROBIOL, V16, P235, DOI 10.1016/j.conb.2006.03.001
Saxe R, 2003, NEUROIMAGE, V19, P1835, DOI 10.1016/S1053-8119(03)00230-1
Schlogl A, 2007, CLIN NEUROPHYSIOL, V118, P98, DOI 10.1016/j.clinph.2006.09.003
Schultz J, 2005, NEURON, V45, P625, DOI 10.1016/j.neuron.2004.12.052
Shulman GL, 2009, J NEUROSCI, V29, P4392, DOI 10.1523/JNEUROSCI.5609-08.2009
Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031
Sugranyes G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025322
Takarae Y, 2008, J INT NEUROPSYCH SOC, V14, P980, DOI 10.1017/S1355617708081277
Toal F, 2010, PSYCHOL MED, V40, P1171, DOI 10.1017/S0033291709991541
Tremoulet PD, 2000, PERCEPTION, V29, P943, DOI 10.1068/p3101
Tsermentseli S, 2008, J AUTISM DEV DISORD, V38, P1201, DOI 10.1007/s10803-007-0500-3
Vandenbroucke MWG, 2008, J AUTISM DEV DISORD, V38, P941, DOI 10.1007/s10803-007-0467-0
Van Overwalle F, 2009, HUM BRAIN MAPP, V30, P829, DOI 10.1002/hbm.20547
Via E, 2011, ARCH GEN PSYCHIAT, V68, P409, DOI 10.1001/archgenpsychiatry.2011.27
Wainwright JA, 1996, J AUTISM DEV DISORD, V26, P423, DOI 10.1007/BF02172827
Worsley KJ, 2002, NEUROIMAGE, V15, P1, DOI 10.1006/nimg.2001.0933
Yu KK, 2011, J PSYCHIATR NEUROSCI, V36, P412, DOI 10.1503/jpn.100138
Zwickel J, 2011, SOC COGN AFFECT NEUR, V6, P564, DOI 10.1093/scan/nsq088
NR 98
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1433
EP 1446
DI 10.1007/s10803-013-2008-3
PG 14
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400015
PM 24305776
ER
PT J
AU Taylor, JL
Smith, LE
Mailick, MR
AF Taylor, Julie Lounds
Smith, Leann E.
Mailick, Marsha R.
TI Engagement in Vocational Activities Promotes Behavioral Development for
Adults with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Adult; Vocation; Autism symptoms; Behavior
problems; Activities of daily living
ID RECEPTIVE LANGUAGE DISORDER; FAMILY-LIFE-STYLES; YOUNG-ADULTS;
FOLLOW-UP; HOME-ENVIRONMENT; MENTAL-HEALTH; DIAGNOSTIC INTERVIEW;
EARLY-CHILDHOOD; ADOLESCENTS; CHILDREN
AB This study examined the bidirectional relations over time between behavioral functioning (autism symptoms, maladaptive behaviors, activities of daily living) and vocational/educational activities of adults with autism spectrum disorders (ASD). Participants were 153 adults with ASD (M age = 30.2 years) who were part of a larger longitudinal study. Data were collected at two time points separated by 5.5 years. Cross-lag models were used, which accounted for stability over time while testing both directions of cross-lagged effects. Results suggested that greater vocational independence and engagement was related to subsequent reductions in autism symptoms and maladaptive behaviors, and improvements in activities of daily living. Relations between earlier behavioral variables (symptoms, behaviors, and activities of daily living) and later vocational independence were not statistically significant.
C1 [Taylor, Julie Lounds] Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
[Taylor, Julie Lounds] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
[Taylor, Julie Lounds] Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN USA.
[Smith, Leann E.; Mailick, Marsha R.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
RP Taylor, JL (reprint author), Vanderbilt Kennedy Ctr, Peabody Box 40,230 Appleton Pl, Nashville, TN 37203 USA.
EM Julie.l.taylor@vanderbilt.edu
CR Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
American Association on Intellectual and Developmental Disabilities, 2010, INTELLECTUAL DISABIL
Baker JK, 2011, J FAM PSYCHOL, V25, P601, DOI 10.1037/a0024409
BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
BALTES PB, 1980, ANNU REV PSYCHOL, V31, P65, DOI 10.1146/annurev.ps.31.020180.000433
Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x
Blustein DL, 2008, AM PSYCHOL, V63, P228, DOI 10.1037/0003-066X.63.4.228
Bollen KA, 2006, WILEY SER PROBAB ST, P1
BRADLEY RH, 1979, DEV PSYCHOL, V15, P246
Bruininks R., 1996, SCALES INDEPENDENT B
Cederlund M, 2008, J AUTISM DEV DISORD, V38, P72, DOI 10.1007/s10803-007-0364-6
Cicchetti D, 2009, J CHILD PSYCHOL PSYC, V50, P16, DOI 10.1111/j.1469-7610.2008.01979.x
CLARKEST.KA, 1973, MONOGR SOC RES CHILD, V38, P1, DOI 10.2307/1165928
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
DeNavas-Walt C., 2004, INCOME POVERTY HLTH
DOOLEY D, 1980, PSYCHOL BULL, V87, P450, DOI 10.1037//0033-2909.87.3.450
Dove D, 2012, PEDIATRICS, V130, P717, DOI 10.1542/peds.2012-0683
Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
Esbensen AJ, 2013, AJIDD-AM J INTELLECT, V118, P294, DOI 10.1352/1944-7558-118.4.294
Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69
Fecteau S, 2003, AUTISM, V7, P255, DOI 10.1177/1362361303007003003
Feldman DC, 1996, J MANAGE, V22, P385, DOI 10.1177/014920639602200302
FELDMAN DC, 1995, J ORGAN BEHAV, V16, P691, DOI 10.1002/job.4030160708
Friedland DS, 2003, AM J COMMUN PSYCHOL, V32, P33, DOI 10.1023/A:1025638705649
Garcia-Villamisar D, 2000, J VOCATIONAL REHABIL, V14, P183
Garcia-Villamisar D., 2002, J VOCATIONAL REHABIL, V17, P309
GILLBERG C, 1987, J AUTISM DEV DISORD, V17, P273, DOI 10.1007/BF01495061
Greenberg JS, 2006, AM J MENT RETARD, V111, P229, DOI 10.1352/0895-8017(2006)111[229:BEOEEA]2.0.CO;2
Hansen HT, 2005, EUR SOCIOL REV, V21, P135, DOI 10.1093/esr/jci009
Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2
Hill A, 2001, PSYCHOPATHOLOGY, V34, P187, DOI 10.1159/000049305
Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
Howlin P, 2013, J AM ACAD CHILD PSY, V52, P572, DOI 10.1016/j.jaac.2013.02.017
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
KENNY DA, 1975, PSYCHOL BULL, V82, P887, DOI 10.1037/0033-2909.82.6.887
Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
Lord C., 2002, CHILD ADOL PSYCH CL, P664
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lounds J, 2007, AM J MENT RETARD, V112, P401, DOI 10.1352/0895-8017(2007)112[401:TACIAA]2.0.CO;2
Maenner MJ, 2013, DISABIL HEALTH J, V6, P8, DOI 10.1016/j.dhjo.2012.08.005
Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
McGovern CW, 2005, J CHILD PSYCHOL PSYC, V46, P401, DOI 10.1111/j.1469-7610.2004.00361.x
McKee-Ryan FM, 2005, J APPL PSYCHOL, V90, P53, DOI 10.1037/0021-9010.90.1.53
MINK IT, 1987, AM J MENT RETARD, V92, P57
MINK IT, 1986, DEV PSYCHOL, V22, P610, DOI 10.1037/0012-1649.22.5.610
Murphy GC, 1999, J OCCUP ORGAN PSYCH, V72, P83, DOI 10.1348/096317999166518
Muthen L. K., 2009, MPLUS 5 21 STAT ANAL
NIHIRA K, 1983, AM J MENT DEF, V88, P139
NIHIRA K, 1985, DEV PSYCHOL, V21, P784, DOI 10.1037//0012-1649.21.5.784
Paul KI, 2009, J VOCAT BEHAV, V74, P264, DOI 10.1016/j.jvb.2009.01.001
Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
Rutter M., 1990, STRAIGHT DEVIOUS PAT
Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
Schulenberg JE, 2004, DEV PSYCHOPATHOL, V16, P1119, DOI 10.1017/S0954579404040167
Seltzer M. M., 2011, AUTISM SPECTRUM DISO, P241, DOI DOI 10.1093/MED/9780195371826.003.0016
Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
Shattuck PT, 2007, J AUTISM DEV DISORD, V37, P1735, DOI 10.1007/s10803-006-0307-7
Shea V., 2005, HDB AUTISM PERVASIVE, V1, P312
SHEPPERDSON B, 1995, J INTELL DISABIL RES, V39, P419
Smith LE, 2012, J AM ACAD CHILD PSY, V51, P622, DOI 10.1016/j.jaac.2012.03.001
Smith LE, 2008, AM J MENT RETARD, V113, P387, DOI 10.1352/2008.113:387-402
Sparrow S. S., 1993, VINELAND SCREENER
SROUFE LA, 1984, CHILD DEV, V55, P17, DOI 10.2307/1129832
Taylor JL, 2012, J AUTISM DEV DISORD, V42, P2669, DOI 10.1007/s10803-012-1524-x
Taylor JL, 2014, DEV PSYCHOL, V50, P699, DOI 10.1037/a0034297
Taylor JL, 2012, PEDIATRICS, V130, P531, DOI 10.1542/peds.2012-0682
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
Taylor JL, 2010, J AUTISM DEV DISORD, V40, P1431, DOI 10.1007/s10803-010-1005-z
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
Tonge BJ, 2003, INT REV RES MENT RET, V26, P61, DOI 10.1016/S0074-7750(03)01002-4
Woodman A. C., TRAJECTORI IN PRESS
NR 80
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1447
EP 1460
DI 10.1007/s10803-013-2010-9
PG 14
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400016
PM 24287880
ER
PT J
AU Horder, J
Wilson, CE
Mendez, MA
Murphy, DG
AF Horder, Jamie
Wilson, C. Ellie
Mendez, M. Andreina
Murphy, Declan G.
TI Autistic Traits and Abnormal Sensory Experiences in Adults
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Adults; Anxiety; Autism; Comorbidities; Sensory
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; ASPERGER-SYNDROME;
CHILDREN; SYMPTOMS; TODDLERS; PATTERNS; ANXIETY; PROFILE; AQ
AB Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the 'broader phenotype' of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p < 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine.
C1 [Horder, Jamie; Wilson, C. Ellie; Mendez, M. Andreina; Murphy, Declan G.] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England.
[Murphy, Declan G.] Kings Coll London, Inst Psychiat, Sackler Ctr Translat Neurodev, London SE5 8AF, England.
RP Horder, J (reprint author), Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, De Crespigny Pk,POB 50, London SE5 8AF, England.
EM jamie.horder@kcl.ac.uk
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bell V, 2006, SCHIZOPHRENIA BULL, V32, P366, DOI 10.1093/schbul/sbj014
Ben-Sasson A, 2007, AM J OCCUP THER, V61, P584
Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
Boyd BA, 2009, RES AUTISM SPECT DIS, V3, P959, DOI 10.1016/j.rasd.2009.05.003
Chamak B, 2008, PSYCHOTHER PSYCHOSOM, V77, P271, DOI 10.1159/000140086
Brock ME, 2012, J AUTISM DEV DISORD, V42, P2271, DOI 10.1007/s10803-012-1472-5
Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
Buse D. C., 2012, J NEUROL, V260, P1960
Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005
Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794
De la Marche W, 2012, RES AUTISM SPECT DIS, V6, P639, DOI 10.1016/j.rasd.2011.09.014
Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026
Donnellan A. A., 2013, FRONT INTEGR NEUROSC, V6, P124, DOI [DOI 10.3389/FNINT.2012.00124, 10. 3389/fnint. 2012.00124]
Dunn W., 2002, ADULT ADOLESCENT SEN
Elwin M, 2012, ARCH PSYCHIAT NURS, V26, P420, DOI 10.1016/j.apnu.2011.10.003
Elwin M, 2013, J INTELLECT DEV DIS, V38, P232, DOI 10.3109/13668250.2013.815694
Haigh SM, 2012, CEPHALALGIA, V32, P236, DOI 10.1177/0333102411433301
Horder, 2013, TRANSL PSYCHIAT, V3, pe279
Kientz MA, 1997, AM J OCCUP THER, V51, P530
Lane SJ, 2012, AM J OCCUP THER, V66, P595, DOI 10.5014/ajot.2012.004523
LeCouteur A, 1996, J CHILD PSYCHOL PSYC, V37, P785
Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
Mendez M. A., 2012, NEUROPHARMACOLOGY, V68, P195, DOI 10.1016/j.neuropharm.2012.04.008
ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170
Orekhova EV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039906
Panagopoulos VN, 2013, PEERJ, V1, DOI 10.7717/peerj.121
Robertson AE, 2012, J AUTISM DEV DISORD, V43, P775
Robledo Jodi, 2012, Front Integr Neurosci, V6, P107, DOI 10.3389/fnint.2012.00107
Schaaf, 2013, J AUTISM DEV DISORD
Schieve LA, 2012, MATERN CHILD HLTH J, V16, pS151, DOI 10.1007/s10995-012-1004-0
Spielberger C., 1970, MANUAL STATE TRAIT A
Tannan V, 2008, AUTISM RES, V1, P223, DOI 10.1002/aur.34
Watling RL, 2001, AM J OCCUP THER, V55, P416
White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
Zaroff C. M., 2011, SOC PSYCH PSYCH EPID, V47, P395, DOI DOI 10.1007/S00127-011-0350-3
NR 41
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1461
EP 1469
DI 10.1007/s10803-013-2012-7
PG 9
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400017
PM 24305777
ER
PT J
AU Stevenson, RA
Siemann, JK
Woynaroski, TG
Schneider, BC
Eberly, HE
Camarata, SM
Wallace, MT
AF Stevenson, Ryan A.
Siemann, Justin K.
Woynaroski, Tiffany G.
Schneider, Brittany C.
Eberly, Haley E.
Camarata, Stephen M.
Wallace, Mark T.
TI Brief Report: Arrested Development of Audiovisual Speech Perception in
Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Sensory processing; Multisensory integration; Speech perception;
Audiovisual; McGurk effect
ID AUDITORY SPEECH; VISUAL INFLUENCES; CHILDHOOD AUTISM; SOCIAL BRAIN;
CHILDREN; INTEGRATION; LANGUAGE; COMMUNICATION; RECOGNITION; ACQUISITION
AB Atypical communicative abilities are a core marker of Autism Spectrum Disorders (ASD). A number of studies have shown that, in addition to auditory comprehension differences, individuals with autism frequently show atypical responses to audiovisual speech, suggesting a multisensory contribution to these communicative differences from their typically developing peers. To shed light on possible differences in the maturation of audiovisual speech integration, we tested younger (ages 6-12) and older (ages 13-18) children with and without ASD on a task indexing such multisensory integration. To do this, we used the McGurk effect, in which the pairing of incongruent auditory and visual speech tokens typically results in the perception of a fused percept distinct from the auditory and visual signals, indicative of active integration of the two channels conveying speech information. Whereas little difference was seen in audiovisual speech processing (i.e., reports of McGurk fusion) between the younger ASD and TD groups, there was a significant difference at the older ages. While TD controls exhibited an increased rate of fusion (i.e., integration) with age, children with ASD failed to show this increase. These data suggest arrested development of audiovisual speech integration in ASD. The results are discussed in light of the extant literature and necessary next steps in research.
C1 [Stevenson, Ryan A.] Vanderbilt Univ, Med Ctr, Vanderbilt Brain Inst, Vanderbilt Kennedy Ctr,Dept Hearing & Speech Sci, Nashville, TN 37232 USA.
[Stevenson, Ryan A.] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada.
[Siemann, Justin K.] Vanderbilt Univ, Neurosci Grad Program, Nashville, TN 37232 USA.
[Woynaroski, Tiffany G.; Camarata, Stephen M.] Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci, Nashville, TN 37232 USA.
[Schneider, Brittany C.; Eberly, Haley E.] Vanderbilt Univ, Program Neurosci, Nashville, TN 37232 USA.
[Wallace, Mark T.] Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci Psychol & Psychiat, Vanderbilt Brain Inst,Vanderbilt Kennedy Ctr, Nashville, TN 37232 USA.
RP Stevenson, RA (reprint author), Vanderbilt Univ, Med Ctr, Vanderbilt Brain Inst, Vanderbilt Kennedy Ctr,Dept Hearing & Speech Sci, 7110 MRB 3 BioSci Bldg,465 21st Ave South, Nashville, TN 37232 USA.
EM ryan.andrew.stevenson@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association DSM-5 Task Force, 2013, DIAGN STAT MAN MENT, V5th
Arnold P, 2001, BRIT J PSYCHOL, V92, P339, DOI 10.1348/000712601162220
BAGGALEY AR, 1988, EDUC PSYCHOL MEAS, V48, P89, DOI 10.1177/001316448804800111
Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x
Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x
Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016
Boddaert N, 2002, PEDIATR RADIOL, V32, P1
Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
Calvert GA, 1998, TRENDS COGN SCI, V2, P247, DOI 10.1016/S1364-6613(98)01189-9
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220
Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
FRICK RW, 1995, MEM COGNITION, V23, P132, DOI 10.3758/BF03210562
HOCKLEY WE, 1994, MEM COGNITION, V22, P713, DOI 10.3758/BF03209256
Iarocci G, 2010, AUTISM, V14, P305, DOI 10.1177/1362361309353615
Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
Irwin JR, 2011, CHILD DEV, V82, P1397, DOI 10.1111/j.1467-8624.2011.01619.x
Jones J. A., 1997, Canadian Acoustics, V25
Kanner L, 1943, NERV CHILD, V2, P217
Kuhl PK, 2004, NAT REV NEUROSCI, V5, P831, DOI 10.1038/nrn1533
Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x
Kuhl PK, 2007, DEVELOPMENTAL SCI, V10, P110, DOI 10.1111/j.1467-7687.2007.00572.x
Kwakye Leslie D, 2011, Front Integr Neurosci, V4, P129, DOI 10.3389/fnint.2010.00129
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
MACDONALD J, 1978, PERCEPT PSYCHOPHYS, V24, P253, DOI 10.3758/BF03206096
Massaro D. W., 1998, PERCEIVING TALKING F
MASSARO DW, 1984, CHILD DEV, V55, P1777, DOI 10.1111/j.1467-8624.1984.tb00420.x
Massaro DW, 1996, J ACOUST SOC AM, V100, P1777, DOI 10.1121/1.417342
MASSARO DW, 1995, CURR DIR PSYCHOL SCI, V4, P104, DOI 10.1111/1467-8721.ep10772401
MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0
Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
MIDDELWEERD MJ, 1987, J ACOUST SOC AM, V82, P2145, DOI 10.1121/1.395659
Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y
Munhall KG, 1996, PERCEPT PSYCHOPHYS, V58, P351, DOI 10.3758/BF03206811
Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366
Pelphrey KA, 2008, ANN NY ACAD SCI, V1145, P283, DOI 10.1196/annals.1416.007
Pelphrey KA, 2008, DEV PSYCHOPATHOL, V20, P1081, DOI 10.1017/S0954579408000515
Pierce K, 2008, BIOL PSYCHIAT, V64, P552, DOI 10.1016/j.biopsych.2008.05.013
Powers AR, 2012, J NEUROSCI, V32, P6263, DOI 10.1523/JNEUROSCI.6138-11.2012
Powers AR, 2009, J NEUROSCI, V29, P12265, DOI 10.1523/JNEUROSCI.3501-09.2009
Quinto L, 2010, ATTEN PERCEPT PSYCHO, V72, P1450, DOI 10.3758/APP.72.6.1450
Rosenblum LD, 1997, PERCEPT PSYCHOPHYS, V59, P347, DOI 10.3758/BF03211902
Ross LA, 2011, EUR J NEUROSCI, V33, P2329, DOI 10.1111/j.1460-9568.2011.07685.x
Sekiyama K, 2008, DEVELOPMENTAL SCI, V11, P306, DOI 10.1111/j.1467-7687.2008.00677.x
Soto-Faraco S, 2004, COGNITION, V92, pB13, DOI 10.1016/j.cognition.2003.10.005
Stevenson RA, 2013, EXP BRAIN RES, V225, P479, DOI 10.1007/s00221-012-3387-y
Stevenson RA, 2012, J EXP PSYCHOL HUMAN, V38, P1517, DOI 10.1037/a0027339
SUMBY WH, 1954, J ACOUST SOC AM, V26, P212, DOI 10.1121/1.1907309
Talsma D, 2010, TRENDS COGN SCI, V14, P400, DOI 10.1016/j.tics.2010.06.008
Taylor N, 2010, J AUTISM DEV DISORD, V40, P1403, DOI 10.1007/s10803-010-1000-4
Tsao FM, 2004, CHILD DEV, V75, P1067, DOI 10.1111/j.1467-8624.2004.00726.x
van Wassenhove V, 2005, P NATL ACAD SCI USA, V102, P1181, DOI 10.1073/pnas.0408949102
Wechsler D, 1999, WECHSLER ABBREVIATED
Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
Woynaroski TG, 2013, J AUTISM DEV DISORD, V43, P2891, DOI 10.1007/s10803-013-1836-5
Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
NR 61
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1470
EP 1477
DI 10.1007/s10803-013-1992-7
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400018
PM 24218241
ER
PT J
AU Jing, W
Fang, JM
AF Jing, Wei
Fang, Junming
TI Brief Report: Do Children with Autism Gather Information from Social
Contexts to Aid Their Word Learning?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism disorder; Social contexts; Word learning; Late childhood
ID ALTERNATIVE ACCOUNT; LANGUAGE; INFANTS; ABILITY
AB Typically developing (TD) infants could capitalize on social eye gaze and social contexts to aid word learning. Although children with autism disorder (AD) are known to exhibit atypicality in word learning via social eye gaze, their ability to utilize social contexts for word learning is not well understood. We investigated whether verbal AD children exhibit word learning ability via social contextual cues by late childhood. We found that AD children, unlike TD controls, failed to infer the speaker's referential intention through information gathered from the social context. This suggests that TD children can learn words in diverse social pragmatic contexts in as early as toddlerhood whereas AD children are still unable to do so by late childhood.
C1 [Jing, Wei] Shaanxi Normal Univ, Coll Educ, Xian, Shaanxi, Peoples R China.
[Fang, Junming] E China Normal Univ, Dept Presch & Special Educ, Shanghai 200062, Peoples R China.
RP Jing, W (reprint author), Shaanxi Normal Univ, Coll Educ, 199 South Changan Rd, Xian, Shaanxi, Peoples R China.
EM ling_zero@126.com; fangjunming1946@126.com
CR Akechi H, 2011, RES AUTISM SPECT DIS, V5, P1230, DOI 10.1016/j.rasd.2011.01.013
Akhtar N, 1996, CHILD DEV, V67, P635, DOI 10.2307/1131837
BALDWIN DA, 1993, J CHILD LANG, V20, P395
BaronCohen S, 1997, CHILD DEV, V68, P48
Briganti AM, 2011, INFANT BEHAV DEV, V34, P211, DOI 10.1016/j.infbeh.2010.12.012
Diesendruck G, 2004, DEVELOPMENTAL SCI, V7, P33, DOI 10.1111/j.1467-7687.2004.00320.x
Gliga T, 2012, CHILD DEV, V83, P926, DOI 10.1111/j.1467-8624.2012.01750.x
HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
Hollich G. J., 2000, MONOGR SOC RES CHILD, V65, P1, DOI [10.1111/1540-5834.00091, DOI 10.1111/1540-5834.00090]
Houston-Price C, 2006, J EXP CHILD PSYCHOL, V95, P27, DOI 10.1016/j.jecp.2006.03.006
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Li D., 1989, COMBINED RAVENS TEST
Parish-Morris J, 2007, CHILD DEV, V78, P1265, DOI 10.1111/j.1467-8624.2007.01065.x
Peterson CC, 2005, CHILD DEV, V76, P502, DOI 10.1111/j.1467-8624.2005.00859.x
Preissler M. A., 2005, COGNITION, V97, P13
Samuelson LK, 1998, CHILD DEV, V69, P94, DOI 10.1111/j.1467-8624.1998.tb06136.x
Sang B., 1990, PSYCHOL SCI, V14, P20
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Steele S, 2003, J AUTISM DEV DISORD, V33, P461, DOI 10.1023/A:1025075115100
Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
Tager-Flusberg H, 2004, J AUTISM DEV DISORD, V34, P75, DOI 10.1023/B:JADD.0000018077.64617.5a
Tomasello M, 1996, J CHILD LANG, V23, P157
NR 22
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1478
EP 1482
DI 10.1007/s10803-013-1994-5
PG 5
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400019
PM 24234720
ER
PT J
AU Shrestha, M
Shrestha, R
AF Shrestha, Merina
Shrestha, Rena
TI Symptom Recognition to Diagnosis of Autism in Nepal
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Early intervention; Health seeking
AB Awareness and knowledge about autism is almost non-existent in Nepal. Children who eventually get the diagnosis often miss their opportunity for early intervention. The current study shows that medical help was seeked at mean age of 27.9 + 14.5 months and most of them were for delayed language and the first preference for parents were pediatricians. The mean age of diagnosis of autism was 55.6 months. The time length between help seeking to diagnosis was 29.4 months with longest time lag of 13 years. Delay in recognition of symptoms, delay in health seeking and lack of awareness even in treating physicians might be the reason for advanced age at diagnosis of autism in Nepal.
C1 [Shrestha, Merina] Tribhuvan Univ, Teaching Hosp, Dept Child Hlth, Kathmandu, Nepal.
[Shrestha, Merina; Shrestha, Rena] Autism Care Nepal, Kathmandu, Nepal.
[Shrestha, Rena] Tribhuvan Univ, Dept Psychol, Kathmandu, Nepal.
RP Shrestha, M (reprint author), Tribhuvan Univ, Teaching Hosp, Dept Child Hlth, Kathmandu, Nepal.
EM drmerinashrestha@gmail.com
CR [Anonymous], 2010, BAS SURV PERS DIS HA
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Daley TC, 2004, SOC SCI MED, V58, P1323, DOI 10.1016/S0277-9536(03)00330-7
Imran N., 2011, BMC PEDIAT, V11
Khatri G. K., 2011, Journal of Nepal Paediatric Society, V31, P98, DOI 10.3126/jnps.v31i2.4640
Ministry of Health and Population, 2006, WHO AIMS REP MENT HL
Ministry of Health and Population, 2011, NEP DEM HLTH SURV
Sauvey S, 2005, INDIAN PEDIATR, V42, P697
Tulachan P., 2011, J PSYCHIAT ASS NEPAL, V1, P20
United Nations, 2010, NEP MILL DEV GOALS R
NR 10
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2014
VL 44
IS 6
BP 1483
EP 1485
DI 10.1007/s10803-013-2005-6
PG 3
WC Psychology, Developmental
SC Psychology
GA AH7RN
UT WOS:000336331400020
PM 24293038
ER
PT J
AU Mynatt, BS
Gibbons, MM
Hughes, A
AF Mynatt, Blair Sumner
Gibbons, Melinda M.
Hughes, Amber
TI Career Development for College Students With Asperger's Syndrome
SO JOURNAL OF CAREER DEVELOPMENT
LA English
DT Article
DE Asperger's syndrome; college students; social cognitive career theory
ID AUTISM SPECTRUM DISORDERS; SELF-EFFICACY BELIEFS; HIGH-SCHOOL-STUDENTS;
DISABILITIES; INDIVIDUALS; CHILDREN; LIFE; ADOLESCENTS; PERSPECTIVE;
PERFORMANCE
AB An increasing number of students with Asperger's syndrome are entering college today. Students with Asperger's syndrome face complex symptomology such as difficulty with social skills, narrowed interests, sensory issues, and lack of self-awareness that may affect their ability to complete college and successfully enter the workforce. Career counselors could apply social cognitive career theory as an effective intervention when working with college students diagnosed with Asperger's syndrome. A case illustration is presented as an example.
C1 [Mynatt, Blair Sumner; Gibbons, Melinda M.; Hughes, Amber] Univ Tennessee, Dept Educ Psychol & Counseling, Knoxville, TN 37996 USA.
RP Mynatt, BS (reprint author), Univ Tennessee, Dept Educ Psychol & Counseling, 432 Claxton Complex,1122 Volunteer Blvd, Knoxville, TN 37996 USA.
EM bmynatt@utk.edu
CR American Psychiatric Association, 2004, DIAGN STAT MAN MENT
Anderson SL, 2001, J VOCAT BEHAV, V58, P98, DOI 10.1006/jvbe.2000.1753
Bandura A., 1986, SOCIAL FDN THOUGHT A
Barnhill G. P., 2007, FOCUS AUTISM OTHER D, V22, P116, DOI DOI 10.1177/10883576070220020301
Brown SD, 1996, CAREER DEV Q, V44, P354
Brown SD, 2008, J VOCAT BEHAV, V72, P298, DOI 10.1016/j.jvb.2007.09.003
Bureau of Labor Statistics, 2012, USDL121125 BUR LAB S
Cederlund M, 2010, RES DEV DISABIL, V31, P287, DOI 10.1016/j.ridd.2009.09.006
Channon S, 2001, J AUTISM DEV DISORD, V31, P461, DOI 10.1023/A:1012212824307
Desivilya HS, 2005, INT J CONFL MANAGE, V16, P183, DOI 10.1108/eb022928
DeWitz SJ, 2009, J COLL STUDENT DEV, V50, P19
Dritschel B, 2010, AUTISM, V14, P509, DOI 10.1177/1362361310368407
Emrich D., 2003, J AUTISM DEV DISORD, V33, P253
Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508
Gibbons MM, 2010, CAREER DEV Q, V58, P194
Graetz J. E., 2008, J COLL ADMISSION WIN, P16
Griffin HC, 2006, INTERV SCH CLIN, V41, P150, DOI 10.1177/10534512060410030401
Hampton NZ, 2003, J SCHOOL PSYCHOL, V41, P101, DOI 10.1016/S0022-4405(03)00028-1
Howlin P., 2003, J AUTISM DEV DISORD, V33, P2
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
Hurlbutt KS, 2010, INTERV SCH CLIN, V46, P46, DOI 10.1177/1053451210369521
Hutchinson NL, 2008, WORK, V30, P123
Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
Kanai C, 2011, RES AUTISM SPECT DIS, V5, P1451, DOI 10.1016/j.rasd.2011.02.005
Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
Kuusikko S, 2008, J AUTISM DEV DISORD, V38, P1697, DOI 10.1007/s10803-008-0555-9
Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
Lee HJ, 2007, REM SPEC EDUC, V28, P132
LENT RW, 1994, J VOCAT BEHAV, V45, P79, DOI 10.1006/jvbe.1994.1027
Lent RW, 1996, CAREER DEV Q, V44, P310
Lopata C, 2007, PERCEPT MOTOR SKILL, V104, P1183, DOI 10.2466/PMS.104.4.1183-1192
Morris CAW, 2009, CAREER DEV Q, V58, P44
Muller E, 2008, AUTISM, V12, P173, DOI 10.1177/1362361307086664
Myles BS, 2007, EDUC TRAIN DEV DISAB, V42, P448
National Center for Education Statistics U.S. Department of Education, 2008, TABL 231 NUMB PERC S
Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
Rice Catherine, 2009, Morbidity and Mortality Weekly Report, V58, P1
Rogers ME, 2008, J VOCAT BEHAV, V73, P132, DOI 10.1016/j.jvb.2008.02.002
Semrud-Clikeman M, 2010, J ABNORM CHILD PSYCH, V38, P509, DOI 10.1007/s10802-009-9380-7
Smith C. P., 2007, COLL STUDENT J, V41, P515
South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3
VanBergeijk E, 2008, J AUTISM DEV DISORD, V38, P1359, DOI 10.1007/s10803-007-0524-8
Whitehouse J. O., 2009, J ADOLESCENCE, V32, P309, DOI [10.1016/j.adolescence.2008.03.004, DOI 10.1016/J.ADOLESCENCE]
Winter-Messiers M., 2007, FOCUS AUTISM OTHER D, V22, P67, DOI 10.1177/10883576070220020701
Winter-Messiers MA, 2007, REM SPEC EDUC, V28, P140, DOI 10.1177/07419325070280030301
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 46
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0894-8453
EI 1556-0856
J9 J CAREER DEV
JI J. Career Dev.
PD JUN
PY 2014
VL 41
IS 3
BP 185
EP 198
DI 10.1177/0894845313507774
PG 14
WC Psychology, Applied
SC Psychology
GA AG8DW
UT WOS:000335650000002
ER
PT J
AU Voigt, RG
Mellon, MW
Katusic, SK
Weaver, AL
Matern, D
Mellon, B
Jensen, CL
Barbaresi, WJ
AF Voigt, Robert G.
Mellon, Michael W.
Katusic, Slavica K.
Weaver, Amy L.
Matern, Dietrich
Mellon, Bryan
Jensen, Craig L.
Barbaresi, William J.
TI Dietary Docosahexaenoic Acid Supplementation in Children With Autism
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE autism; complementary and alternative therapy; dietary supplements;
docosahexaenoic acid; fish oil; -3 fatty acids; pervasive developmental
disorders
ID ESSENTIAL FATTY-ACIDS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
PLACEBO-CONTROLLED TRIAL; GROUP RANDOMIZED-TRIALS; DOUBLE-BLIND;
PSYCHOACTIVE MEDICINES; CEREBROSPINAL-FLUID; UPDATED GUIDELINES; BRAIN;
SEROTONIN
AB Objective:The aim of the study was to determine whether docosahexaenoic acid (DHA) supplementation improves the behavior of children with autism.Methods:A group of 3- to 10-year-old children with autism were randomized in a double-blind fashion to receive a supplement containing 200 mg of DHA or a placebo for 6 months. The parents and the investigator completed the Clinical Global Impressions-Improvement scale to rate changes in core symptoms of autism after 3 and 6 months. The parents completed the Child Development Inventory and the Aberrant Behavior Checklist, and both parents and teachers completed the Behavior Assessment Scale for Children (BASC) at enrollment and after 6 months.Results:A total of 48 children (40 [83%] boys, mean age [standard deviation] 6.1 [2.0] years) were enrolled; 24 received DHA and 24 placebo. Despite a median 431% increase in total plasma DHA levels after 6 months, the DHA group was not rated as improved in core symptoms of autism compared to the placebo group on the CGI-I. Based on the analysis of covariance models adjusted for the baseline rating scores, parents (but not teachers) provided a higher average rating of social skills on the BASC for the children in the placebo group compared to the DHA group (P=0.04), and teachers (but not parents) provided a higher average rating of functional communication on the BASC for the children in the DHA group compared to the placebo group (P=0.02).Conclusions:Dietary DHA supplementation of 200 mg/day for 6 months does not improve the core symptoms of autism. Our results may have been limited by inadequate sample size.
C1 [Voigt, Robert G.; Mellon, Bryan] Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USA.
[Mellon, Michael W.] Mayo Clin, Dept Psychol & Psychiat, Rochester, MN USA.
[Katusic, Slavica K.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
[Weaver, Amy L.; Matern, Dietrich] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
[Jensen, Craig L.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Barbaresi, William J.] Childrens Hosp, Dept Med, Boston, MA 02115 USA.
RP Voigt, RG (reprint author), Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Meyer Ctr Dev Pediat, 8080 North Stadium Dr,Suite 180, Houston, TX 77054 USA.
EM rgvoigt@bcm.edu
FU Mayo Foundation; Mead Johnson Nutritional
FX The study was supported by funding from the Mayo Foundation. The DHA
supplements and placebos used in this study were provided by Martek
Biosciences Corporation (Columbia, MD).C.L.J. has been a consultant and
has received payment for lectures and for development of educational
presentations from Mead Johnson Nutritional. The other authors report no
conflicts of interest.
CR Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
Aman MG, 2004, CNS SPECTRUMS, V9, P36
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anderson GM, 2002, J AM ACAD CHILD PSY, V41, P1513, DOI 10.1097/01.CHI.0000024874.60748.28
Assies J, 2001, BIOL PSYCHIAT, V49, P510, DOI 10.1016/S0006-3223(00)00986-0
Astarita G, 2010, PLOS ONE, V5
Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
Barbaresi WJ, 2005, ARCH PEDIAT ADOL MED, V159, P37, DOI 10.1001/archpedi.159.1.37
Bauman ML, 1996, J AUTISM DEV DISORD, V26, P199, DOI 10.1007/BF02172012
Bazan NG, 2007, CURR OPIN CLIN NUTR, V10, P136, DOI 10.1097/MCO.0b013e32802b7030
Bell JG, 2004, PROSTAG LEUKOTR ESS, V71, P201, DOI 10.1016/j.plefa.2004.03.008
Brown EC, 2002, RES DEV DISABIL, V23, P45, DOI 10.1016/S0891-4222(01)00091-9
Bu B, 2006, PROSTAG LEUKOTR ESS, V74, P215, DOI 10.1016/j.plefa.2006.02.001
FARQUHARSON J, 1995, ARCH DIS CHILD, V72, P198
Filipek PA, 2000, NEUROLOGY, V55, P468
Hamazaki T, 1996, J CLIN INVEST, V97, P1129, DOI 10.1172/JCI118507
Hanson E, 2004, J DEV BEHAV PEDIATR, V25, P380, DOI 10.1097/00004703-200410000-00036
HIBBELN JR, 1995, AM J CLIN NUTR, V62, P1
Hibbeln JR, 1998, LANCET, V351, P1213, DOI 10.1016/S0140-6736(05)79168-6
Hibbeln JR, 1998, BIOL PSYCHIAT, V44, P243, DOI 10.1016/S0006-3223(98)00143-7
Hibbeln JR, 1998, BIOL PSYCHIAT, V44, P235, DOI 10.1016/S0006-3223(98)00141-3
Hirayama S, 2004, EUR J CLIN NUTR, V58, P467, DOI 10.1038/sj.ejcn.1601830
Hyman SL, 2000, CONT PEDIAT, V17, P101
Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
INNIS SM, 1991, PROG LIPID RES, V30, P39, DOI 10.1016/0163-7827(91)90006-Q
Ireton H, 1992, CHILD DEV INVENTORY
Lagerstedt SA, 2001, MOL GENET METAB, V73, P38, DOI 10.1006/mgme.2001.3170
Langworthy-Lam KS, 2002, J CHILD ADOL PSYCHOP, V12, P311, DOI 10.1089/104454602762599853
LEVITSKY DA, 1995, J NUTR, V125, pS2212
Lipkin PH, 1996, DEV DISABILITIES INF, P137
MAKRIDES M, 1994, AM J CLIN NUTR, V60, P189
Moher D, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c869
National Institute of Mental Health, 1985, PSYCHOPHARMACOL BULL, V21, P839
CAMPBELL M, 1985, PSYCHOPHARMACOL BULL, V21, P1063
National Research Council. Committee on Educational Interventions for Children with Autism, 2001, DIV BEH SOC SCI ED E
NEURINGER M, 1988, ANNU REV NUTR, V8, P517
New York State Department of Health Early Intervention Program, 1999, NEW YORK STAT DEP HL
Noaghiul S, 2003, AM J PSYCHIAT, V160, P2222, DOI 10.1176/appi.ajp.160.12.2222
Palacios-Pelaez R, 2010, MOL NEUROBIOL, V41, P367, DOI 10.1007/s12035-010-8139-z
Peet M, 2001, SCHIZOPHR RES, V49, P243, DOI 10.1016/S0920-9964(00)00083-9
Quinn JF, 2010, JAMA-J AM MED ASSOC, V304, P1903, DOI 10.1001/jama.2010.1510
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
Richardson AJ, 2005, PEDIATRICS, V115, P1360, DOI 10.1542/peds.2004-2164
Salem N, 2001, LIPIDS, V36, P945, DOI 10.1007/s11745-001-0805-6
Sandler AD, 1999, NEW ENGL J MED, V341, P1801, DOI 10.1056/NEJM199912093412404
SASTRY PS, 1985, PROG LIPID RES, V24, P69, DOI 10.1016/0163-7827(85)90011-6
Schopler E, 2004, CHILDHOOD AUTISM RAT
Schulz KF, 2010, BRIT MED J, V340, DOI 10.1136/bmj.c332
Sparks BF, 2002, NEUROLOGY, V59, P184
Starrett AL, 1996, DEV DISABILITIES INF, P593
Stevens L, 2003, LIPIDS, V38, P1007, DOI 10.1007/s11745-006-1155-0
STEVENS LJ, 1995, AM J CLIN NUTR, V62, P761
Stoll AL, 1999, ARCH GEN PSYCHIAT, V56, P407, DOI 10.1001/archpsyc.56.5.407
Stordy BJ, 2000, AM J CLIN NUTR, V71, p323S
STRUPP BJ, 1995, J NUTR, V125, pS2221
Vancassel S, 2001, PROSTAG LEUKOTR ESS, V65, P1, DOI 10.1054/plef.2001.0281
van der Merwe LF, 2013, AM J CLIN NUTR, V97, P45, DOI 10.3945/ajcn.112.042267
Voigt RG, 2001, J PEDIATR-US, V139, P189, DOI 10.1067/mpd.2001.116050
NR 59
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD JUN
PY 2014
VL 58
IS 6
BP 715
EP 722
DI 10.1097/MPG.0000000000000260
PG 8
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA AH6SS
UT WOS:000336261600016
PM 24345834
ER
PT J
AU Billingslea, EN
Tatard-Leitman, VM
Anguiano, J
Jutzeler, CR
Suh, J
Saunders, JA
Morita, S
Featherstone, RE
Ortinski, PI
Gandal, MJ
Lin, R
Liang, YL
Gur, RE
Carlson, GC
Hahn, CG
Siegel, SJ
AF Billingslea, Eddie N.
Tatard-Leitman, Valerie M.
Anguiano, Jaynie
Jutzeler, Catherine R.
Suh, Jimmy
Saunders, John A.
Morita, Susumu
Featherstone, Robert E.
Ortinski, Pavel I.
Gandal, Michael J.
Lin, Robert
Liang, Yuling
Gur, Raquel E.
Carlson, Gregory C.
Hahn, Chang-Gyu
Siegel, Steven J.
TI Parvalbumin Cell Ablation of NMDA-RI Causes Increased Resting Network
Excitability with Associated Social and Self-Care Deficits
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID INBRED MOUSE STRAINS; SPECTRUM DISORDERS; GAMMA OSCILLATIONS;
SCHIZOPHRENIA; MICE; KETAMINE; AUTISM; ANTAGONIST; RESPONSES; MODEL
AB NMDA-receptor (NMDAR) hypofunction is strongly implicated in the pathophysiology of schizophrenia. Several convergent lines of evidence suggest that net excitation propagated by impaired NMDAR signaling on GABAergic intemeurons may be of particular interest in mediating several aspects of schizophrenia. However, it is unclear which behavioral domains are govrned by a net increase of excitation and whether modulating downstream GABAergic signaling can reverse neural and thus behavioral deficits. The current study determines the selective contributions of NMDAR dysfunction on PV-containing intemeurons to electrophysiological, cognitive, and negative-symptom-related behavioral phenotypes of schizophrenia using mice with a PVcre-NRI flox-driven ablation of NRI on PV-containing intemeurons. In addition, we assessed the efficacy of one agent that directly modulates GABAergic signaling (baclofen) and one agent that indirectly modifies NMDAR-mediated signaling through antagonism of mGluR5 receptors (2-methyl-6-(phenylethynyl) pyridine (MPEP)). The data indicate that loss of NMDAR function on PV intemeurons impairs self-care and sociability while increasing NI latency and baseline gamma power, and reducing induction and maintenance of long-term potentiation. Baclofen normalized baseline gamma power without corresponding effects on behavior. MPEP further increased NI latency and reduced social behavior in PVcre/ NRI +1+ mice. These two indices were negatively correlated before and following MPEP such that as NI latency increases, sociability decreases. This finding suggests a predictive role for NI latency with respect to social function. Although previous data suggest that MPEP may be beneficial for core features of autism spectrum disorders, current data suggest that such effects require intact function of NMDAR on PV interneurons.
C1 [Billingslea, Eddie N.; Tatard-Leitman, Valerie M.; Anguiano, Jaynie; Jutzeler, Catherine R.; Suh, Jimmy; Saunders, John A.; Morita, Susumu; Featherstone, Robert E.; Ortinski, Pavel I.; Gandal, Michael J.; Lin, Robert; Liang, Yuling; Gur, Raquel E.; Carlson, Gregory C.; Hahn, Chang-Gyu; Siegel, Steven J.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
RP Siegel, SJ (reprint author), Univ Penn, Translat Res Labs, Room 2202,125 S 31st St, Philadelphia, PA 19104 USA.
EM siegels@upenn.edu
FU Developmental funds from the University of Pennsylvania;
[5R01DA023210-04]; [5R01MH074672 -04]; [1P50MH096891-01];
[T32MH019112]
FX Funding was provided by 5R01DA023210-04 (Siegel), 5R01MH074672 -04 (SJ
Siegel), 1P50MH096891-01 (RE Gur), T32MH019112 to RE (Gur), as well as
Developmental funds from the University of Pennsylvania (SJ Siegel).
CR Amann LC, 2009, NEUROBIOL DIS, V35, P311, DOI 10.1016/j.nbd.2009.05.012
Arnold LE, 2000, J AUTISM DEV DISORD, V30, P99, DOI 10.1023/A:1005451304303
Belforte JE, 2010, NAT NEUROSCI, V13, P76, DOI 10.1038/nn.2447
Boutros NN, 2009, SCHIZOPHR RES, V113, P339, DOI 10.1016/j.schres.2009.05.019
Burket JA, 2011, BRAIN RES BULL, V86, P152, DOI 10.1016/j.brainresbull.2011.08.001
CAPECCHI MR, 1989, SCIENCE, V244, P1288, DOI 10.1126/science.2660260
Carlen M, 2012, MOL PSYCHIATR, V17, P537, DOI 10.1038/mp.2011.31
Carlson GC, 2011, P NATL ACAD SCI USA, V108, pE962, DOI 10.1073/pnas.1109625108
Connolly PM, 2004, NEUROCHEM RES, V29, P1179, DOI 10.1023/B:NERE.0000023605.68408.fb
Deacon RMJ, 2006, NAT PROTOC, V1, P1117, DOI 10.1038/nprot.2006.170
Deacon RMJ, 2006, NAT PROTOC, V1, P7, DOI 10.1038/nprot.2006.2
Delorme A, 2004, J NEUROSCI METH, V134, P9, DOI 10.1016/j.jneumeth.2003.10.009
Ehrlichman RS, 2008, J COGNITIVE NEUROSCI, V20, P1403, DOI 10.1162/jocn.2008.20097
Ehrlichman RS, 2009, NEUROSCIENCE, V158, P705, DOI 10.1016/j.neuroscience.2008.10.031
Featherstone RE, 2013, PSYCHOPHARMACOLOGY, V227, P639, DOI 10.1007/s00213-013-2997-9
Featherstone RE, 2012, NEUROBIOL DIS, V47, P338, DOI 10.1016/j.nbd.2012.05.003
Gandal MJ, 2008, NEUROSCIENCE, V157, P95, DOI 10.1016/j.neuroscience.2008.08.060
Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031
Gandal MJ, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.69
Gur RC, 2001, NEUROPSYCHOPHARMACOL, V25, P777, DOI 10.1016/S0893-133X(01)00279-2
Halene TB, 2009, GENES BRAIN BEHAV, V8, P661, DOI 10.1111/j.1601-183X.2009.00504.x
Hippenmeyer S, 2005, PLOS BIOL, V3, P878, DOI 10.1371/journal.pbio.0030159
Hugdahl Kenneth, 2009, Front Neurosci, V3, P34, DOI 10.3389/neuro.01.001.2009
JAVITT DC, 1994, AM J PSYCHIAT, V151, P1234
KRYSTAL JH, 1994, ARCH GEN PSYCHIAT, V51, P199
LAHTI AC, 1995, NEUROPSYCHOPHARMACOL, V13, P9, DOI 10.1016/0893-133X(94)00131-I
Lazarewicz MT, 2010, J COGNITIVE NEUROSCI, V22, P1452, DOI 10.1162/jocn.2009.21305
Maxwell CR, 2006, J PHARMACOL EXP THER, V316, P315, DOI 10.1124/jpet.105.091199
Mehta MV, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026077
Pacey LKK, 2009, MOL PHARMACOL, V76, P18, DOI 10.1124/mol.109.056127
Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
Sankoorikal GMV, 2006, BIOL PSYCHIAT, V59, P415, DOI 10.1016/j.biopsych.2005.07.026
Saunders JA, 2012, BEHAV BRAIN RES, V234, P233, DOI 10.1016/j.bbr.2012.06.032
Saunders John A, 2013, Autism Res, V6, P69, DOI 10.1002/aur.1264
Siegel SJ, 2006, AM J PSYCHIAT, V163, P433, DOI 10.1176/appi.ajp.163.3.433
Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
Silverman JL, 2012, SCI TRANSL MED, V4
Tsien JZ, 1996, CELL, V87, P1317, DOI 10.1016/S0092-8674(00)81826-7
Turetsky BI, 2008, BIOL PSYCHIAT, V64, P1051, DOI 10.1016/j.biopsych.2008.06.018
Van Balkom IDC, 2012, DEV MED CHILD NEUROL, V54, P925, DOI 10.1111/j.1469-8749.2012.04339.x
Winterer G, 2000, CLIN NEUROPHYSIOL, V111, P837, DOI 10.1016/S1388-2457(99)00322-3
Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
NR 42
TC 8
Z9 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD JUN
PY 2014
VL 39
IS 7
BP 1603
EP 1613
DI 10.1038/npp.2014.7
PG 11
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AH4OG
UT WOS:000336107300006
PM 24525709
ER
PT J
AU Seese, RR
Maske, AR
Lynch, G
Gall, CM
AF Seese, Ronald R.
Maske, Anna R.
Lynch, Gary
Gall, Christine M.
TI Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2
Activation and Reversed by mGluR5 Antagonism in an Animal Model of
Autism
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE BTBR; Fmrl KO; object location memory; cAMP response element binding
protein (CREB); positive AMPA receptor modulator (ampakine); MPEP
ID T PLUS TF/J; FRAGILE-X-SYNDROME; BTBR MOUSE MODEL; SPECTRUM DISORDERS;
SOCIAL BEHAVIORS; T+TF/J MICE; PLASTICITY; ADULT; PREVALENCE; CORTEX
AB A significant proportion of patients with autism exhibit some degree of intellectual disability. The BTBR T+ Itpr3(tf/)J mouse strain exhibits behaviors that align with the major diagnostic criteria of autism. To further evaluate the BTBR strain's cognitive impairments, we quantified hippocampus-dependent object location memory (OLM) and found that one-third of the BTBR mice exhibited robust memory, whereas the remainder did not Fluorescence deconvolution tomography was used to test whether synaptic levels of activated extracellular signal-regulated kinase 1/2 (ERK1/2), a protein that contributes importantly to plasticity, correlate with OLM scores in individual mice. In hippocampal field CA1, the BTBRs had fewer post-synaptic densities associated with high levels of phosphorylated (p-) ERK1/2 as compared with C57BL/6 mice. Although counts of p-ERK1/2 immunoreactive synapses did not correlate with OLM performance, the intensity of synaptic p-ERK1/2 immunolabeling was negatively correlated with OLM scores across BTBRs. Metabotropic glutamate receptor (mGluR) 5 signaling activates ERK1/2. Therefore, we tested whether treatment with the mGluR5 antagonist MPEP normalizes synaptic and learning measures in BTBR mice: MPEP facilitated OLM and decreased synaptic p-ERK1/2 immunolabeling intensity without affecting numbers of p-ERK1/2 synapses. In contrast, semi-chronic ampakine treatment, which facilitates memory in other models of cognitive impairment, had no effect on OLM in BTBRs. These results suggest that intellectual disabilities associated with different neurodevelopmental disorders on the autism spectrum require distinct therapeutic strategies based on underlying synaptic pathology.
C1 [Seese, Ronald R.; Maske, Anna R.; Lynch, Gary; Gall, Christine M.] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA.
[Lynch, Gary] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA.
[Gall, Christine M.] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA.
RP Gall, CM (reprint author), Univ Calif Irvine, Sch Med, Dept Anat & Neurobiol, Irvine, CA 92697 USA.
EM cmgall@uci.edu
FU National Institutes of Health [MH082042, NS04260]; UC Irvine Center for
Autism Research and Treatment; NIMH predoctoral fellowship [FMH095432A];
[T32-GM0862]
FX This work was supported by National Institutes of Health grants MH082042
and NS04260 and the UC Irvine Center for Autism Research and Treatment.
R.R.S. was supported by grant T32-GM0862 and NIMH predoctoral fellowship
FMH095432A. Drs Lynch and Gall are coauthors on patents, owned by the
University of California, for the use of ampakines to support cognitive
function (Lynch) and increase endogenous BDNF expression (Lynch, Gall).
CR Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
Aoki C, 2001, SYNAPSE, V40, P239, DOI 10.1002/syn.1047
Babineau BA, 2013, PHYSIOL BEHAV, V114, P49, DOI 10.1016/j.physbeh.2013.03.006
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
Baudry M, 2012, NEUROBIOL DIS, V47, P210, DOI 10.1016/j.nbd.2012.04.002
Belichenko PV, 2007, J COMP NEUROL, V504, P329, DOI 10.1002/cne.21433
Bernard-Trifilo JA, 2005, J NEUROCHEM, V93, P834, DOI 10.1111/j.1471-4159.2005.03062.x
Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007
Bryson SE, 2008, CAN J PSYCHIAT, V53, P449
Chen LY, 2010, J NEUROSCI, V30, P10977, DOI 10.1523/JNEUROSCI.1077-10.2010
de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002
Fombonne E., 2006, UNDERSTANDING AUTISM, P25
Haettig J, 2011, LEARN MEMORY, V18, P71, DOI 10.1101/lm.1986911
Hou LF, 2006, NEURON, V51, P441, DOI 10.1016/j.neuron.2006.07.005
Hung AY, 2008, J NEUROSCI, V28, P1697, DOI 10.1523/JNEUROSCI.3032-07.2008
Hurst JL, 2010, NAT METHODS, V7, P825, DOI [10.1038/nmeth.1500, 10.1038/NMETH.1500]
Kalkman HO, 2012, NEUROSCI BIOBEHAV R, V36, P2206, DOI 10.1016/j.neubiorev.2012.07.008
Kramar EA, 2012, NEUROBIOL AGING, V33, P708, DOI 10.1016/j.neurobiolaging.2010.06.008
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
La Malfa G, 2004, J INTELL DISABIL RES, V48, P262, DOI 10.1111/j.1365-2788.2003.00567.x
Langen M, 2011, NEUROSCI BIOBEHAV R, V35, P345, DOI 10.1016/j.neubiorev.2010.02.004
Lipina TV, 2013, NEUROPHARMACOLOGY, V64, P283, DOI 10.1016/j.neuropharm.2012.06.054
Lu YM, 1997, J NEUROSCI, V17, P5196
MacPherson P, 2008, BRAIN RES, V1210, P179, DOI 10.1016/j.brainres.2008.03.008
McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
Meyza KZ, 2013, BEHAV BRAIN RES, V251, P25, DOI 10.1016/j.bbr.2012.07.021
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Moy SS, 2006, AM J MED GENET C, V142C, P40, DOI 10.1002/ajmg.c.30081
Patterson PH, 2011, PEDIATR RES, V69, p34R, DOI 10.1203/PDR.0b013e318212b80f
Ribeiro AS, 2013, BEHAV BRAIN RES, V245, P145, DOI 10.1016/j.bbr.2013.02.021
Rutz HLH, 2012, BEHAV BRAIN RES, V234, P33, DOI 10.1016/j.bbr.2012.05.048
Samuels IS, 2009, NEURON, V61, P160, DOI 10.1016/j.neuron.2009.01.001
Satoh Y, 2011, J NEUROSCI, V31, P11953, DOI 10.1523/JNEUROSCI.2349-11.2011
Scattoni ML, 2011, GENES BRAIN BEHAV, V10, P44, DOI 10.1111/j.1601-183X.2010.00623.x
Seese RR, 2013, J NEUROSCI, V33, P13441, DOI 10.1523/JNEUROSCI.2434-13.2013
Seese RR, 2012, J NEUROSCI, V32, P7403, DOI 10.1523/JNEUROSCI.0968-12.2012
Silverman JL, 2013, NEUROPHARMACOLOGY, V64, P268, DOI 10.1016/j.neuropharm.2012.07.013
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
Silverman JL, 2012, SCI TRANSL MED, V4
Simmons DA, 2009, P NATL ACAD SCI USA, V106, P4906, DOI 10.1073/pnas.0811228106
Thomas GM, 2004, NAT REV NEUROSCI, V5, P173, DOI 10.1038/nrn1346
Tropea D, 2009, P NATL ACAD SCI USA, V106, P2029, DOI 10.1073/pnas.0812394106
Ventura R, 2004, BEHAV PHARMACOL, V15, P433, DOI 10.1097/00008877-200409000-00018
Wang JQ, 2007, J NEUROCHEM, V100, P1, DOI 10.1111/j.1471-4159.2006.04208.x
Wohr M, 2011, GENES BRAIN BEHAV, V10, P35, DOI 10.1111/j.1601-183X.2010.00582.x
Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
Yang M, 2012, PHYSIOL BEHAV, V107, P649, DOI 10.1016/j.physbeh.2011.12.025
Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008
Yoshii A, 2010, DEV NEUROBIOL, V70, P304, DOI 10.1002/dneu.20765
Yu CG, 2005, MOL BRAIN RES, V138, P244, DOI 10.1016/j.molbrainres.2005.04.013
Zou H, 2011, GENES BRAIN BEHAV, V10, P615, DOI 10.1111/j.1601-183X.2011.00702.x
NR 53
TC 6
Z9 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD JUN
PY 2014
VL 39
IS 7
BP 1664
EP 1673
DI 10.1038/npp.2014.13
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AH4OG
UT WOS:000336107300012
PM 24448645
ER
PT J
AU Hoogenhout, M
Malcolm-Smith, S
AF Hoogenhout, Michelle
Malcolm-Smith, Susan
TI Theory of mind in autism spectrum disorder: Does DSM classification
predict development?
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Theory of mind; Development; Autism spectrum disorder; Asperger's
syndrome; Pervasive developmental disorder not otherwise specified; DSM
ID HIGH-FUNCTIONING AUTISM; NONSPECIFIC INTELLECTUAL DISABILITIES;
ASPERGER-SYNDROME; TASK-PERFORMANCE; DIAGNOSTIC-CRITERIA;
NORMAL-CHILDREN; VERBAL-ABILITY; ADULTS; INDIVIDUALS; RECOGNITION
AB It is unclear how theory of mind (TOM; understanding mental states and their influence on behaviour) develops in autism spectrum disorders (ASD). At least two possibilities exist: development is delayed or developmental patterns deviate from normal. We used a cross-sectional design to examine ToM skills in 4-16 year-old children. First, participants were classified in terms of the DSM-IV categories low-functioning autism (n = 21), high-functioning autism (n = 24), Asperger's syndrome (n = 21), and pervasive developmental disorder not otherwise specified (PDD-NOS; n = 20). The high-functioning autism, Asperger's syndrome and PDD-NOS groups displayed delayed ToM onset compared to a typically developing group (n = 30), but normal ToM developmental rates and sequences; supporting delayed development. ToM in low-functioning ASD fit the deviant development model: Age did not predict ToM. A second ToM model using DSM-5 ASD and verbal IQ. supported ToM development differences: Greater verbal ability was associated with increased ToM in ASD but not in typical development. As a single explanation for ToM development in ASD is insufficient, it is imperative to report specifiers such as intellectual functioning when using DSM-5 classification. DSM-IV classification contributed little to the prediction of ToM development beyond the influence of intellectual functioning. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Hoogenhout, Michelle; Malcolm-Smith, Susan] Univ Cape Town, Dept Psychol, ZA-7701 Rondebosch, South Africa.
RP Hoogenhout, M (reprint author), Univ Cape Town, Dept Psychol, ZA-7701 Rondebosch, South Africa.
EM michellehoog@gmail.com; Susan.Malcolm-Smith@uct.ac.za
CR American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
Arsham H., 2014, TEST FOR EQUALITY OF
Barnhill G., 2000, FOCUS AUTISM OTHER D, V15, P146, DOI [10.1177/108835760001500303, DOI 10.1177/108835760001500303]
Baron-Cohen S, 2008, Q J EXP PSYCHOL, V61, P64, DOI 10.1080/17470210701508749
Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
BARONCOHEN S, 1989, J CHILD PSYCHOL PSYC, V30, P285, DOI 10.1111/j.1469-7610.1989.tb00241.x
Bauminger N, 1999, J AUTISM DEV DISORD, V29, P81, DOI 10.1023/A:1025974701090
Begeer S, 2003, J AUTISM DEV DISORD, V33, P479, DOI 10.1023/A:1025875311062
Buitelaar JK, 1999, DEV PSYCHOPATHOL, V11, P39, DOI 10.1017/S0954579499001947
BURACK JA, 1992, J CHILD PSYCHOL PSYC, V33, P607, DOI 10.1111/j.1469-7610.1992.tb00894.x
Charman T, 2002, J DEV PHYS DISABIL, V14, P263, DOI 10.1023/A:1016076405731
Dahlgren SO, 1996, J CHILD PSYCHOL PSYC, V37, P759, DOI 10.1111/j.1469-7610.1996.tb01469.x
Dissanayake C., 2003, INDIVIDUAL DIFFERENC
Fisher N, 2005, J CHILD PSYCHOL PSYC, V46, P409, DOI 10.1111/j.1469-7610.2004.00371.x
FODOR JA, 1992, COGNITION, V44, P283, DOI 10.1016/0010-0277(92)90004-2
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Ghaziuddin M, 2008, J AUTISM DEV DISORD, V38, P138, DOI 10.1007/s10803-007-0371-7
Giaouri S, 2010, PROCD SOC BEHV, V2, P3883, DOI 10.1016/j.sbspro.2010.03.609
Gibbs V, 2012, J AUTISM DEV DISORD, V42, P1750, DOI 10.1007/s10803-012-1560-6
Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
HOLROYD S, 1993, J AUTISM DEV DISORD, V23, P379, DOI 10.1007/BF01046226
Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
Jervis N, 2004, J APPL RES INTELLECT, V17, P49, DOI 10.1111/j.1468-3148.2004.00172.x
Kim Y. S., 2014, JOURNAL OF THE AMERI
Klin A., 2000, THE JOURNAL OF CHILD, V41, P831
Korkman M., 2007, NEPSY II CLINICAL IN
Koyama T, 2008, PSYCHIAT CLIN NEUROS, V62, P691, DOI 10.1111/j.1440-1819.2008.01871.x
Kuroda M, 2011, RES AUTISM SPECT DIS, V5, P554, DOI 10.1016/j.rasd.2010.06.022
Lord C, 2012, J CHILD PSYCHOL PSYC, V53, P490, DOI 10.1111/j.1469-7610.2012.02547.x
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
Matson JL, 2012, J DEV PHYS DISABIL, V24, P403, DOI 10.1007/s10882-012-9278-0
Matson JL, 2012, DEV NEUROREHABIL, V15, P185, DOI 10.3109/17518423.2012.672341
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
Miller SA, 2003, J COGN DEV, V4, P325, DOI 10.1207/S15327647JCD0403_05
Myer L, 2008, SOC SCI MED, V66, P1828, DOI 10.1016/j.socscimed.2008.01.025
Noterdaeme M., 2009, EUROPEAN J CHILD ADO, V19, P475
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027
Paynter J, 2010, RES AUTISM SPECT DIS, V4, P377, DOI 10.1016/j.rasd.2009.10.005
Peterson CC, 2005, CHILD DEV, V76, P502, DOI 10.1111/j.1467-8624.2005.00859.x
Sattler J., 2008, RESOURCE GUIDE TO AC
Scheeren AM, 2013, J CHILD PSYCHOL PSYC, V54, P628, DOI 10.1111/jcpp.12007
Serra M, 2002, J CHILD PSYCHOL PSYC, V43, P885, DOI 10.1111/1469-7610.00104
SODIAN B, 1987, CHILD DEV, V58, P424, DOI 10.1111/j.1467-8624.1987.tb01390.x
SPARREVOHN R, 1995, J CHILD PSYCHOL PSYC, V36, P249, DOI 10.1111/j.1469-7610.1995.tb01823.x
Spek A. A., 2009, J AUTISM DEV DISORD, V40, P280, DOI [10.1007/s10803-009-0860-y, DOI 10.1007/S10803-009-0860-Y]
Steele S, 2003, J AUTISM DEV DISORD, V33, P461, DOI 10.1023/A:1025075115100
Tager-Flusberg H, 2007, CURR DIR PSYCHOL SCI, V16, P311, DOI 10.1111/j.1467-8721.2007.00527.x
Thede LL, 2007, J AUTISM DEV DISORD, V37, P847, DOI 10.1007/s10803-006-0212-0
Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5
Wechsler D., 2002, WESCHLER PRESCHOOL A
Wechsler D, 1999, WECHSLER ABBREVIATED
Weitlauf AS, 2014, J AUTISM DEV DISORD, V44, P471, DOI 10.1007/s10803-013-1882-z
Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
Yirmiya N, 1998, PSYCHOL BULL, V124, P283, DOI 10.1037/0033-2909.124.3.283
Ziatas K, 1998, J CHILD PSYCHOL PSYC, V39, P755, DOI 10.1017/S0021963098002510
NR 60
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 597
EP 607
DI 10.1016/j.rasd.2014.02.005
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200001
ER
PT J
AU Roberts, AL
Koenen, KC
Lyall, K
Ascherio, A
Weisskopf, MG
AF Roberts, Andrea L.
Koenen, Karestan C.
Lyall, Kristen
Ascherio, Alberto
Weisskopf, Marc G.
TI Women's posttraumatic stress symptoms and autism spectrum disorder in
their children
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Posttraumatic stress disorder; Gestational
effects
ID CHILDHOOD GENDER NONCONFORMITY; ANTENATAL MATERNAL ANXIETY; MALE VIETNAM
VETERANS; PSYCHIATRIC-DISORDERS; PARENTING STRESS; GENERAL-POPULATION;
PRENATAL EXPOSURE; SOCIAL SUPPORT; ELEVATED RISK; MOTHERS
AB Maternal posttraumatic stress disorder (PTSD) may be associated with autism spectrum disorder (ASD) in offspring through multiple pathways: maternal stress may affect the fetus; ASD in children may increase risk of PTSD in mothers; and the two disorders may share genetic risk. Understanding whether maternal PTSD is associated with child's ASD is important for clinicians treating children with ASD, as PTSD in parents is associated with poorer family functioning. We examined the association of maternal PTSD with offspring ASD in a large US cohort (N ASD cases = 413, N controls = 42,868). Mother's PTSD symptoms were strongly associated with child's ASD (RR 4-5 PTSD symptoms = 1.98, 95% CI = 1.39, 2.81; RR 6-7 symptoms = 2.89, 95% CI = 2.00, 4.18). Clinicians treating persons with ASD should be aware of elevated risk of PTSD in the mother. Genetic studies should investigate PTSD risk alleles in relation to ASD. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Roberts, Andrea L.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
[Koenen, Karestan C.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
[Lyall, Kristen; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Lyall, Kristen] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Ascherio, Alberto; Weisskopf, Marc G.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Weisskopf, Marc G.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
RP Roberts, AL (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, 401 Pk Dr, Boston, MA 02115 USA.
EM aroberts@hsph.harvard.edu
CR Acierno R., 2007, AM J PUBLIC HLTH S1, V97, P5103
Afifi TO, 2010, CLIN PSYCHOL REV, V30, P101, DOI 10.1016/j.cpr.2009.10.002
Andresen E. M., 1994, AM J PREVENTIVE MED
Astin M C, 1993, Violence Vict, V8, P17
Baibazarova E., 2012, PSYCHONEUROENDOCRINO
Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
BEBKO JM, 1987, J AUTISM DEV DISORD, V17, P565, DOI 10.1007/BF01486971
Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
BERNSTEIN DP, 1994, AM J PSYCHIAT, V151, P1132
Bisson JI, 2007, BRIT J PSYCHIAT, V190, P97, DOI 10.1192/bjp.bp.106.021402
Bolte S, 2007, J AUTISM DEV DISORD, V37, P243, DOI 10.1007/s10803-006-0165-3
Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
Breslau N, 1999, AM J PSYCHIAT, V156, P908
Brimacombe M, 2007, MATERN CHILD HLTH J, V11, P73, DOI 10.1007/s10995-006-0142-7
Brownlie EB, 2007, J ABNORM CHILD PSYCH, V35, P618, DOI 10.1007/s10802-007-9117-4
Casey LB, 2012, RES AUTISM SPECT DIS, V6, P1186, DOI 10.1016/j.rasd.2012.03.008
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Daniels JL, 2008, PEDIATRICS, V121, pE1357, DOI 10.1542/peds.2007-2296
Davidson AC, 2001, AUST NZ J PSYCHIAT, V35, P345, DOI 10.1046/j.1440-1614.2001.00897.x
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
DePrince Anne P, 2005, J Trauma Dissociation, V6, P125, DOI 10.1300/J229v06n01_08
Dietert RR, 2008, J TOXICOL ENV HEAL B, V11, P660, DOI 10.1080/10937400802370923
Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
Foa E. B., 2008, EFFECTIVE TREATMENTS, V2nd
Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
Glover V, 2004, EARLY HUM DEV, V79, P107, DOI 10.1016/j.earlhumdev.2004.04.012
Gray DE, 2002, SOCIOL HEALTH ILL, V24, P734, DOI 10.1111/1467-9566.00316
Gurnot C., 2013, EPIGENETICS, V8, P0
Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
Hodge D, 2011, J DEV PHYS DISABIL, V23, P227, DOI 10.1007/s10882-010-9218-9
Holeva V, 2001, BEHAV THER, V32, P65, DOI 10.1016/S0005-7894(01)80044-7
HUTTUNEN MO, 1978, ARCH GEN PSYCHIAT, V35, P429
Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017
Ingersoll B, 2011, AUTISM RES, V4, P143, DOI 10.1002/aur.170
Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
JORDAN BK, 1992, J CONSULT CLIN PSYCH, V60, P916, DOI 10.1037/0022-006X.60.6.916
Jovanovic T, 2011, J CHILD PSYCHOL PSYC, V52, P844, DOI 10.1111/j.1469-7610.2011.02410.x
Juul-Dam N, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.4.e63
Jyonouchi H, 2001, J NEUROIMMUNOL, V120, P170, DOI 10.1016/S0165-5728(01)00421-0
Kinney DK, 2008, J AUTISM DEV DISORD, V38, P481, DOI 10.1007/s10803-007-0414-0
Koenen KC, 2008, J AFFECT DISORDERS, V105, P109, DOI 10.1016/j.jad.2007.04.021
Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
Kubzansky LD, 2013, JAMA PSYCHIAT, V71, P44
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Li J, 2009, PEDIATRICS, V123, P1102, DOI 10.1542/peds.2008-1734
Locke J., 2010, J RES SPECIAL ED NEE, V10, P74, DOI DOI 10.1111/J.1471-3802.2010.01148.X
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Mak WWS, 2010, SOC SCI MED, V70, P2045, DOI 10.1016/j.socscimed.2010.02.023
Marinovic-Curin J, 2008, EUR CHILD ADOLES PSY, V17, P39, DOI 10.1007/s00787-007-0632-1
Martin LA, 2008, BRAIN BEHAV IMMUN, V22, P806, DOI 10.1016/j.bbi.2007.12.007
Micali N, 2004, AUTISM, V8, P21, DOI 10.1177/1362361304040636
Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
Monteleone M. C., 2014, EPIGENETICS, V9, P0
Moore D, 1995, DISCIPLINING CHILDRE
Morgan CA, 2001, AM J PSYCHIAT, V158, P1239, DOI 10.1176/appi.ajp.158.8.1239
Oberlander TF, 2008, EPIGENETICS, V3, P97
O'Connor TG, 2002, BRIT J PSYCHIAT, V180, P502, DOI 10.1192/bjp.180.6.502
Onore C., 2011, BRAIN BEHAV IMMUNITY
Parker VJ, 2010, J REPROD IMMUNOL, V85, P86, DOI 10.1016/j.jri.2009.10.011
Parks KA, 2008, PSYCHOL WOMEN QUART, V32, P145, DOI 10.1111/j.1471-6402.2008.00419.x
Parsons J., 1990, SCH PSYCHOL INT
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Qureshi SU, 2009, PSYCHIAT QUART, V80, P87, DOI 10.1007/s11126-009-9096-4
Rezendes D. L., 2011, AUTISM RES TREATMENT, P2011
Roberts AL, 2012, PEDIATRICS, V129, P410, DOI 10.1542/peds.2011-1804
Roberts AL, 2012, AM J PUBLIC HEALTH, V102, P1587, DOI 10.2105/AJPH.2011.300530
Roberts AL, 2013, JAMA PSYCHIAT, V70, P508, DOI 10.1001/jamapsychiatry.2013.447
Roberts AL, 2012, BIOL PSYCHIAT, V72, P505, DOI 10.1016/j.biopsych.2012.03.020
Roberts AL, 2013, J AM ACAD CHILD PSY, V52, P143, DOI 10.1016/j.jaac.2012.11.006
Samper RE, 2004, J TRAUMA STRESS, V17, P311, DOI 10.1023/B:JOTS.0000038479.30903.ed
SAPOLSKY RM, 1990, J NEUROSCI, V10, P2897
Sawyer MG, 2010, J AUTISM DEV DISORD, V40, P620, DOI 10.1007/s10803-009-0912-3
Schechter DS, 2005, ATTACH HUM DEV, V7, P313, DOI 10.1080/14616730500246011
Schnurr P., 1995, BRIEF TRAUMA I UNPUB
Schumm JA, 2006, J TRAUMA STRESS, V19, P825, DOI 10.1002/jts.20159
Seidler GH, 2006, PSYCHOL MED, V36, P1515, DOI 10.1017/S0033291706007963
Sharpe D. L., 2011, COMPREHENSIVE BOOK A, P275
Sullivan PF, 2012, ARCH GEN PSYCHIAT, P1
Sullivan PM, 2000, CHILD ABUSE NEGLECT, V24, P1257, DOI 10.1016/S0145-2134(00)00190-3
Talge NM, 2007, J CHILD PSYCHOL PSYC, V48, P245, DOI 10.1111/j.1469-7610.2007.01714.x
UNO H, 1994, HORM BEHAV, V28, P336, DOI 10.1006/hbeh.1994.1030
Van den Bergh BRH, 2005, NEUROSCI BIOBEHAV R, V29, P237, DOI 10.1016/j.neubiorev.2004.10.007
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
von Kanel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
Wadhwa PD, 1996, PSYCHOSOM MED, V58, P432
Walsh C. E., 2013, GOOD AUTISM PRACTICE, V14, P28
Yehuda R, 2005, J CLIN ENDOCR METAB, V90, P4115, DOI 10.1210/jc.2005-0550
Zou GY, 2004, AM J EPIDEMIOL, V159, P702, DOI 10.1093/aje/kwh090
NR 91
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 608
EP 616
DI 10.1016/j.rasd.2014.02.004
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200002
ER
PT J
AU Conner, CM
White, SW
AF Conner, Caitlin M.
White, Susan W.
TI Stress in mothers of children with autism: Trait mindfulness as a
protective factor
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Mindfulness; Parenting; Stress
ID PARENTING STRESS; PSYCHOMETRIC PROPERTIES; SPECTRUM DISORDER; PERCEIVED
STRESS; SELF-REGULATION; BEHAVIOR; HEALTH; SCALE
AB Mindfulness-based interventions may reduce parents' stress and improve parent-child relationships. Given the chronic nature of autism spectrum disorder (ASD) and its influence on parents' stress, interventions to promote mindfulness may be especially helpful for parents of children with ASD. Prior to undertaking intervention development, it is first necessary to establish the relationship between mindfulness and stress, as other factors like child behavioral difficulties may overshadow the mother's regulation strategies. In a sample of mothers of children with ASD (n = 67) and a comparison sample of mothers without ASD (n = 87), mindfulness was significantly associated with the level of maternal stress above and beyond child behavior problems (non-ASD: beta = -.232; F(1, 64) = 15.749, p < .000; ASD: beta = -.206; F(1, 84) = 15.576, p < .000). Results suggest that interventions to promote mindfulness may be helpful in reducing parenting stress among mothers of children with ASD, as well as mothers of typically developing children. Due to the chronic nature of ASD, such interventions may be particularly applicable. Published by Elsevier Ltd.
C1 [Conner, Caitlin M.; White, Susan W.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24060 USA.
RP Conner, CM (reprint author), Virginia Polytech Inst & State Univ, 109 Williams Hall, Blacksburg, VA 24060 USA.
EM cconner4@vt.edu
CR ABIDIN RR, 1992, J CLIN CHILD PSYCHOL, V21, P407, DOI 10.1207/s15374424jccp2104_12
Aldao A, 2010, BEHAV RES THER, V48, P974, DOI 10.1016/j.brat.2010.06.002
AMAN MG, 1985, AM J MENT DEF, V89, P485
Antony MM, 1998, PSYCHOL ASSESSMENT, V10, P176, DOI 10.1037//1040-3590.10.2.176
Baer RA, 2006, ASSESSMENT, V13, P27, DOI 10.1177/1073191105283504
Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268
Bazzano A., 2013, J CHILD FAM STUD, P1
Benson PR, 2010, RES AUTISM SPECT DIS, V4, P217, DOI 10.1016/j.rasd.2009.09.008
Bishop SR, 2004, CLIN PSYCHOL-SCI PR, V11, P230, DOI 10.1093/clipsy/bph077
Bluth K., 2011, MINDFULNESS, V2, P175, DOI DOI 10.1007/S12671-011-0056-3
Bogels S, 2008, BEHAV COGN PSYCHOTH, V36, P193, DOI 10.1017/S1352465808004190
Bogels S. M., 2010, MINDFULNESS, V1, P107, DOI [10.1007/s12671-010-0014-5, DOI 10.1007/S12671-010-0014-5]
Bridgett DJ, 2013, EMOTION, V13, P47, DOI 10.1037/a0029536
Brown KW, 2003, J PERS SOC PSYCHOL, V84, P822, DOI 10.1037/0022-3514.84.4.822
Chiesa A, 2013, CLIN PSYCHOL REV, V33, P82, DOI 10.1016/j.cpr.2012.10.006
Coatsworth J. D., 2009, J CHILD FAM STUD, V19, P203, DOI [10.1007/s10826-009-9304-8, DOI 10.1007/S10826-009-9304-8]
Cohen J., 2003, APPL MULTIPLE REGRES, P397
COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
Crnic K., 2002, HDB PARENTING, V5, P243
Deater-Deckard K, 2012, J FAM PSYCHOL, V26, P391, DOI 10.1037/a0028331
Deater-Deckard K, 1998, CLIN PSYCHOL-SCI PR, V5, P314
Duncan LG, 2009, CLIN CHILD FAM PSYCH, V12, P255, DOI 10.1007/s10567-009-0046-3
Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
Garland E. L., 2011, MINDFULNESS, V2, P59, DOI DOI 10.1007/S12671-011-0043-8
Gika DM, 2012, PSYCHOL REP, V111, P797, DOI 10.2466/20.15.21.PR0.111.6.797-804
Hayes S. C., 1999, ACCEPTANCE COMMITMEN
Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
Herbert J. D., 2011, ACCEPTANCE MINDFULNE
Howlin P, 1997, AUTISM, V1, P135, DOI DOI 10.1177/1362361397012003
Johnson N, 2011, FAM SYST HEALTH, V29, P232, DOI 10.1037/a0025341
KABATZINN J, 1985, J BEHAV MED, V8, P163, DOI 10.1007/BF00845519
Keng SL, 2011, CLIN PSYCHOL REV, V31, P1041, DOI 10.1016/j.cpr.2011.04.006
Kowalkowski J. D., 2012, THESIS E MICHIGAN U
Lovibond SH, 1995, MANUAL DEPRESSION AN
Lyons AM, 2010, J CHILD FAM STUD, V19, P516, DOI 10.1007/s10826-009-9323-5
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Mitchell AM, 2008, RES NURS HEALTH, V31, P576, DOI 10.1002/nur.20284
Moar K., 2013, MINDFULNESS, V1, P1
Roberti J. W., 2006, J COLL COUNSELING, V9, P13
Singh N. N., 2006, J EMOT BEHAV DISORD, V14, P1
Singh NN, 2007, BEHAV MODIF, V31, P749, DOI 10.1177/0145445507300924
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
van der Oord S, 2012, J CHILD FAM STUD, V21, P139, DOI 10.1007/s10826-011-9457-0
NR 43
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 617
EP 624
DI 10.1016/j.rasd.2014.02.001
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200003
ER
PT J
AU Chen, MH
Su, TP
Chen, YS
Hsu, JW
Huang, KL
Chang, WH
Chen, TJ
Bai, YM
AF Chen, Mu-Hong
Su, Tung-Ping
Chen, Ying-Sheue
Hsu, Ju-Wei
Huang, Kai-Lin
Chang, Wen-Han
Chen, Tzeng-Ji
Bai, Ya-Mei
TI Is neonatal jaundice associated with autism spectrum disorder, attention
deficit hyperactivity disorder, and other psychological development? A
nationwide prospective study
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Neonatal jaundice; ASD; ADHD; Developmental delay
ID DEVELOPMENT CLINICAL-TRIAL; BRAIN-STEM RESPONSES; LOW-BIRTH-WEIGHT;
FOLLOW-UP; DEFICIT/HYPERACTIVITY DISORDER; INFANTILE-AUTISM;
CHILD-HEALTH; HYPERBILIRUBINEMIA; RISK; BILIRUBIN
AB Neonatal jaundice may cause the lifelong sequelae of central nerve system developmental disorders. However, the results are inconsistent. 2016 newborns with neonatal jaundice and 8064 age-/gender-matched (1:4) controls were enrolled during 1999-2000. Participants of autistic spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and other developmental disorders that occurred during the follow-up were identified. Newborns with neonatal jaundice had increased risks of developing ASD (hazard ratio [HR]: 1.75,95% confidence interval [CI]: 1.05-2.90), any developmental delay (HR: 1.27,95% Cl: 1.02-1.58), and developmental speech or language disorder (HR: 1.41, 95% Cl: 1.11-1.79). Newborn exposure to hyperbilirubinemia was related to the increased risk of developing ASD, any developmental delay, and developmental speech or language disorder in later life. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Chen, Mu-Hong; Su, Tung-Ping; Chen, Ying-Sheue; Hsu, Ju-Wei; Huang, Kai-Lin; Chang, Wen-Han; Bai, Ya-Mei] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
[Chen, Mu-Hong; Su, Tung-Ping; Chen, Ying-Sheue; Hsu, Ju-Wei; Huang, Kai-Lin; Bai, Ya-Mei] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan.
[Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
[Su, Tung-Ping] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan.
[Chen, Tzeng-Ji] Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm, Taipei 112, Taiwan.
RP Bai, YM (reprint author), Dept Psychiat, 201,Shih Pai Rd,Sec 2, Taipei 11217, Taiwan.
EM ymbi@mail2000.com.tw
CR Amin SB, 2011, J AUTISM DEV DISORD, V41, P1455, DOI 10.1007/s10803-010-1169-6
Anderson P, 2003, JAMA-J AM MED ASSOC, V289, P3264, DOI 10.1001/jama.289.24.3264
Bai Y. M., 2013, J AFFECTIVE DISORDER
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Chen MH, 2013, J CHILD PSYCHOL PSYC, V54, P545, DOI 10.1111/jcpp.12018
Chu SM, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-85
Croen LA, 2005, PEDIATRICS, V115, pE135, DOI 10.1542/peds.2004-1870
Dennery PA, 2001, NEW ENGL J MED, V344, P581
FINEGAN JA, 1979, J CHILD PSYCHOL PSYC, V20, P119, DOI 10.1111/j.1469-7610.1979.tb00492.x
Funato M, 1996, ACTA PAEDIATR JAPON, V38, P17
Halmoy A, 2012, BIOL PSYCHIAT, V71, P474, DOI 10.1016/j.biopsych.2011.11.013
Hansen T W, 2001, J Perinatol, V21 Suppl 1, pS48, DOI 10.1038/sj.jp.7210634
Hansen TW, 2001, J PERINATOL S1, V21, pS59
Hutchinson EA, 2013, PEDIATRICS, V131, pE1053, DOI 10.1542/peds.2012-2311
JEW JY, 1979, ARCH NEUROL-CHICAGO, V36, P149
Kern JK, 2003, BRAIN DEV-JPN, V25, P377, DOI 10.1016/S0387-7604(03)00056-1
Kessler L, 1969, Z Laryngol Rhinol Otol, V48, P581
Lindstrom K, 2011, PEDIATRICS, V127, P858, DOI 10.1542/peds.2010-1279
Maimburg RD, 2010, PEDIATRICS, V126, P872, DOI 10.1542/peds.2010-0052
Maimburg RD, 2009, ACTA OBSTET GYN SCAN, V88, P1011, DOI 10.1080/00016340903124917
Maimburg RD, 2008, PAEDIATR PERINAT EP, V22, P562, DOI 10.1111/j.1365-3016.2008.00973.x
Maisels MJ, 2006, PEDIATR REV, V27, P443, DOI 10.1542/pir.27-12-443
Newman TB, 2002, PEDIATRICS, V110, P1032, DOI 10.1542/peds.110.5.1032
NEWMAN TB, 1993, PEDIATRICS, V92, P651
Nosarti C, 2012, ARCH GEN PSYCHIAT, V69, P1
Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
Rapin I, 1997, Semin Pediatr Neurol, V4, P86, DOI 10.1016/S1071-9091(97)80024-1
Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
Roth DAE, 2012, DEV MED CHILD NEUROL, V54, P23, DOI 10.1111/j.1469-8749.2011.04149.x
SATO M, 1991, No To Hattatsu, V23, P541
SCHEIDT PC, 1990, PEDIATRICS, V85, P455
SCHEIDT PC, 1991, PEDIATRICS, V87, P797
Seidman D S, 1994, J Perinatol, V14, P23
Shapiro SM, 2003, PEDIATR NEUROL, V29, P410, DOI 10.1016/j.pediatrneurol.2003.09.011
Sidhu M, 2010, INDIAN J PEDIATR, V77, P391, DOI 10.1007/s12098-010-0044-y
TAYLOR MJ, 1982, CAN J NEUROL SCI, V9, P429
Wu CY, 2012, JAMA-J AM MED ASSOC, V308, P1906, DOI 10.1001/2012.jama.11975
NR 37
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 625
EP 632
DI 10.1016/j.rasd.2014.03.006
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200004
ER
PT J
AU Reszka, SS
Hume, KA
Sperry, L
Boyd, BA
McBee, MT
AF Reszka, Stephanie S.
Hume, Kara A.
Sperry, Laurie
Boyd, Brian A.
McBee, Matthew T.
TI The Classroom Practice Inventory: Psychometric evaluation of a rating
scale of intervention practices for children with autism spectrum
disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Classroom practices; Psychometric evaluation; Eclectic; Autism;
Intervention
ID COMPREHENSIVE TREATMENT MODELS; YOUNG-CHILDREN; ASD; IMPLEMENTATION;
RELIABILITY; PROGRAMS; FIDELITY; OUTCOMES; SCHOOL; LEAP
AB The Classroom Practice Inventory (CPI) was developed as a tool to provide descriptive information about the practices used in classrooms to address the developmental needs of children with autism spectrum disorder (ASD). Data from a multi-site study examining the outcomes for preschool students with ASD served in three types of classroom models indicate that the CPI produces reliable and valid assessments of practices used in classrooms. Items on the CPI can be used to discriminate among classroom models and can be used to provide descriptive information about classrooms following a prescribed comprehensive treatment model as well as those providing an eclectic model of services. Implications for the future use of the CPI are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Reszka, Stephanie S.; Hume, Kara A.; Boyd, Brian A.] Univ N Carolina, Chapel Hill, NC USA.
[Sperry, Laurie] Regis Univ, Denver, CO USA.
[McBee, Matthew T.] E Tennessee State Univ, Johnson City, TN 37614 USA.
RP Reszka, SS (reprint author), UNC CH Allied Hlth Sci, 321 S Columbia St,Bondurant Hall CB 7122, Chapel Hill, NC 27599 USA.
EM stephanie.reszka@unc.edu
CR Boyd BA, 2014, J AUTISM DEV DISORD, V44, P366, DOI 10.1007/s10803-013-1877-9
Classroom Practice Inventory, 2007, PROJ STAFF TEACCH LE
Cordisco K., 1994, PRESCHOOL ED PROGRAM, P115
Dillenburger K, 2011, RES AUTISM SPECT DIS, V5, P1119, DOI 10.1016/j.rasd.2010.12.008
Dingfelder HE, 2011, J AUTISM DEV DISORD, V41, P597, DOI 10.1007/s10803-010-1081-0
Durlak JA, 2008, AM J COMMUN PSYCHOL, V41, P327, DOI 10.1007/s10464-008-9165-0
Eikeseth S, 2002, BEHAV MODIF, V26, P49, DOI 10.1177/0145445502026001004
Fava L, 2011, RES AUTISM SPECT DIS, V5, P1479, DOI 10.1016/j.rasd.2011.02.009
Ganz JB, 2008, FOCUS AUTISM DEV DIS, V23, P79, DOI 10.1177/1088357607311447
Gutstein S, 2002, RELATIONSHIP DEV INT
Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
Huberty C. J., 2006, APPL MANOVA DISCRIMI
Hume K, 2011, RES AUTISM SPECT DIS, V5, P1430, DOI 10.1016/j.rasd.2011.02.002
Hume K., 2005, TOP EARLY CHILD SPEC, V25, P194
Kalis T., 2007, PREVENTING SCH FAILU, V51, P20, DOI DOI 10.3200/PSFL.51.3.20-27
Kincaid D., 2003, FOCUS AUTISM OTHER D, V18, P150, DOI DOI 10.1177/10883576030180030301
Mesibov G. B., 2005, STRUCTURED TEACHING
Mesibov GB, 1996, J AUTISM DEV DISORD, V26, P337, DOI 10.1007/BF02172478
MONCHER FJ, 1991, CLIN PSYCHOL REV, V11, P247, DOI 10.1016/0272-7358(91)90103-2
Mowbray CT, 2003, AM J EVAL, V24, P315, DOI 10.1177/109821400302400303
Odom S., 2014, HDB AUTISM PERVASIVE
Odom S, 2012, BEHAV MODIF, V36, P270, DOI 10.1177/0145445512444595
Odom SL, 2010, J AUTISM DEV DISORD, V40, P425, DOI 10.1007/s10803-009-0825-1
Professional Development in Autism Center, 2008, PDA PROGR ASS
Raudenbush S. W., 2002, HIERARCHICAL LINEAR, V2nd
Reichow B, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009260.pub2
SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
Stahmer A., 2010, BRAIN RES, V22, P229
Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
Stahmer AC, 2005, PEDIATRICS, V116, P891, DOI 10.1542/peds.2004-2135
Strain PS, 2000, TOP EARLY CHILD SPEC, V20, P116, DOI 10.1177/027112140002000207
NR 33
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 633
EP 643
DI 10.1016/j.rasd.2014.02.003
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200005
ER
PT J
AU Erstenyuk, V
Swanson, MR
Siller, M
AF Erstenyuk, Valentyna
Swanson, Meghan R.
Siller, Michael
TI Pupillary responses during a joint attention task are associated with
nonverbal cognitive abilities and sub-clinical symptoms of autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Pupil; Joint attention; Gaze following;
Intelligence; Broad autism phenotype
ID TYPICALLY DEVELOPING-CHILDREN; EYE-TRACKING MEASURE;
INDIVIDUAL-DIFFERENCES; 6-MONTH-OLDS; INTELLIGENCE; PERFORMANCE;
SENTENCES; LANGUAGE; BEHAVIOR; INFANTS
AB Measures of pupillary dilation provide a temporally sensitive, quantitative indicator of cognitive resource allocation. The current study included 39 typically developing children between 3 and 9 years of age. Children completed a free-viewing task designed to elicit gaze following, a core deficit of Autism Spectrum Disorders (ASD). Results revealed a negative association between children's pupil dilation and a standardized measure of nonverbal intelligence, suggesting that children with lower intelligence allocated more cognitive resources than children with higher intelligence. In addition, the results revealed a negative association between pupil dilation and a parent-report measure of sub-clinical symptoms of ASD, suggesting that children with fewer ASD-related symptoms allocated more cognitive resources than children who showed more sub-clinical symptoms of ASD. Both associations were independent of each other and could not be explained by variation in chronological age. These findings extend previous research demonstrating associations between basic aspects of visual processing and intelligence. In addition, these findings comport with recent theories of ASD that emphasize reduced sensitivity to the reward value of social situations. When confronted with social ambiguity, children with more ASD-related symptoms allocated fewer cognitive resources to resolving this ambiguity than children who showed fewer sub-clinical symptoms of ASD. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Erstenyuk, Valentyna; Swanson, Meghan R.; Siller, Michael] CUNY Hunter Coll, New York, NY 10065 USA.
[Swanson, Meghan R.; Siller, Michael] CUNY, Grad Ctr, New York, NY 10016 USA.
RP Siller, M (reprint author), CUNY Hunter Coll, Dept Psychol, 695 Pk Ave,Hunter North 611, New York, NY 10065 USA.
EM msiller@hunter.cuny.edu
CR AHERN S, 1979, SCIENCE, V205, P1289, DOI 10.1126/science.472746
BEATTY J, 1982, PSYCHOL BULL, V91, P276, DOI 10.1037/0033-2909.91.2.276
BENNUN Y, 1986, BRAIN LANG, V28, P1, DOI 10.1016/0093-934X(86)90086-6
Beyer R., 2010, PSYCHOPHYSIOLOGY, V47, P158
Bomstein M. H., 1986, CHILD DEV, V57, P251
Brooks R, 2002, DEV PSYCHOL, V38, P958, DOI 10.1037//0012-1649.38.6.958
Brooks R, 2005, DEVELOPMENTAL SCI, V8, P535, DOI 10.1111/j.1467-7687.2005.00445.x
Charman T, 2000, COGNITIVE DEV, V15, P481, DOI 10.1016/S0885-2014(01)00037-5
COLOMBO J, 1995, DEV REV, V15, P97, DOI 10.1006/drev.1995.1005
Constantino JN, 2002, SOCIAL RESPONSIVENES
Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Dawson G., 2012, J NEUROLOGICAL DISOR, V4, P1
D'Entremont B, 2000, DEVELOPMENTAL SCI, V3, P302, DOI 10.1111/1467-7687.00124
D'Entremont B, 1997, INFANT BEHAV DEV, V20, P569, DOI 10.1016/S0163-6383(97)90048-5
Fagan JF, 1983, ADV INFANCY RES, V2, P31
FREESEMAN LJ, 1993, CHILD DEV, V64, P1191, DOI 10.1111/j.1467-8624.1993.tb04195.x
Gagl B, 2011, BEHAV RES METHODS, V43, P1171, DOI 10.3758/s13428-011-0109-5
Granholm E, 1996, PSYCHOPHYSIOLOGY, V33, P457, DOI 10.1111/j.1469-8986.1996.tb01071.x
Heitz RP, 2008, PSYCHOPHYSIOLOGY, V45, P119, DOI 10.1111/j.1469-8986.2007.00605.x
HESS EH, 1964, SCIENCE, V143, P1190, DOI 10.1126/science.143.3611.1190
Houston-Price C, 2006, J EXP CHILD PSYCHOL, V95, P27, DOI 10.1016/j.jecp.2006.03.006
Just M. A., 2003, THEORETICAL ISSUES E, V4, P56, DOI 10.1080/14639220210159735
Kavgek M., 2004, J APPL DEV PSYCHOL, V25, P369
Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
Lowenfeld I. E., 1993, PUPIL
MCCALL RB, 1993, CHILD DEV, V64, P57, DOI 10.1111/j.1467-8624.1993.tb02895.x
Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378
Nelson PB, 2008, DEVELOPMENTAL SCI, V11, P847, DOI 10.1111/j.1467-7687.2008.00733.x
Preacher KJ, 2006, J EDUC BEHAV STAT, V31, P437, DOI 10.3102/10769986031004437
Rypma B, 2006, NEUROIMAGE, V33, P969, DOI 10.1016/j.neuroimage.2006.05.065
SCHLUROFF M, 1982, BRAIN LANG, V17, P133, DOI 10.1016/0093-934X(82)90010-4
SCHLUROFF M, 1986, BRAIN LANG, V27, P322, DOI 10.1016/0093-934X(86)90023-4
Sigman M., 2008, DEV PSYCHOL, V44, P1691
Sigman M, 1997, INFANT BEHAV DEV, V20, P133, DOI 10.1016/S0163-6383(97)90016-3
Sigman M., 1999, MONOGRAPHS SOC RES C, V64, pv, DOI DOI 10.1111/1540-5834.00010
Sigman M, 2004, MENT RETARD DEV D R, V10, P221, DOI 10.1002/mrdd.20046
Smith L, 2003, SOC DEV, V12, P222, DOI 10.1111/1467-9507.00230
Striano T, 2006, EUR J DEV PSYCHOL, V3, P289, DOI 10.1080/17405620600879779
Sung YJ, 2005, AM J HUM GENET, V76, P68, DOI 10.1086/426951
Swanson M., 2013, J AUTISM DEV DISORDE
Swanson MR, 2013, J AUTISM DEV DISORD, V43, P707, DOI 10.1007/s10803-012-1616-7
Swanson MR, 2013, RES AUTISM SPECT DIS, V7, P1087, DOI 10.1016/j.rasd.2013.05.007
Tomasello M., 2005, BEHAV BRAIN SCI, V28, P1
Verney SP, 2004, INT J PSYCHOPHYSIOL, V52, P23, DOI 10.1016/j.ijpsycho.2003.12.003
VERNON PA, 1983, INTELLIGENCE, V7, P53, DOI 10.1016/0160-2896(83)90006-5
NR 46
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 644
EP 653
DI 10.1016/j.rasd.2014.03.003
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200006
ER
PT J
AU Yi, L
Fan, YB
Joseph, L
Huang, D
Wang, XQ
Li, J
Zou, XB
AF Yi, Li
Fan, Yuebo
Joseph, Lisa
Huang, Dan
Wang, Xueqin
Li, Jiao
Zou, Xiaobing
TI Event-based prospective memory in children with autism spectrum
disorder: The role of executive function
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Prospective memory; Autism spectrum disorder; Executive function;
Working memory; Inhibitory control; Event-based prospective memory
ID INTELLIGENCE; PERFORMANCE; VERSION; TASKS
AB The present study investigated event-based prospective memory (PM) and its cognitive correlates in children with autism spectrum disorder (ASD) compared to age- and ability-matched typically developing (TD) peers. Participants included 25 children with ASD, 25 age-matched TO peers, and 28 ability-matched TO peers. Participants completed one PM task, and several executive functioning tasks assessing working memory (Block Recall Task), inhibitory control (Stroop Task), and cognitive flexibility (Dimensional Change Card Sorting Task). Results indicated that children with ASD had significantly lower scores on the PM task than children in the TD groups. Additionally, PM performance of children with ASD was significantly predicted by their nonverbal IQ, whereas PM performance of TO children was significantly predicted by their inhibitory control. These results provide evidence for the PM deficit in children with ASD and the effect of cognitive functioning, rather than a specific aspect of executive function, on the development of PM. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Yi, Li; Joseph, Lisa; Li, Jiao] Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China.
[Fan, Yuebo; Huang, Dan] Guangzhou Cana Sch, Guangzhou, Guangdong, Peoples R China.
[Fan, Yuebo; Huang, Dan] Guangzhou Rehabil & Res Ctr Children ASD, Guangzhou, Guangdong, Peoples R China.
[Wang, Xueqin] Sun Yat Sen Univ, Sch Math & Computat Sci, Dept Stat Sci, Guangzhou 510275, Guangdong, Peoples R China.
[Wang, Xueqin] Sun Yat Sen Univ, Southern China Res Ctr Stat Sci, Guangzhou 510275, Guangdong, Peoples R China.
[Zou, Xiaobing] Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China.
RP Yi, L (reprint author), Sun Yat Sen Univ, Dept Psychol, 135 Xingang West Rd, Guangzhou 510275, Guangdong, Peoples R China.
EM yili5@mail.sysu.edu.cn
CR Altgassen M, 2012, J AUTISM DEV DISORD, V42, P2141, DOI 10.1007/s10803-012-1466-3
Altgassen M, 2010, J NEURODEV DISORD, V2, P2, DOI 10.1007/s11689-009-9030-y
Altgassen M, 2009, BRAIN IMPAIR, V10, P52
American Psychiatric Association, 1994, DIAGN STAT MAN MENT
Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
Brandimonte MA, 2011, MEMORY, V19, P56, DOI 10.1080/09658211.2010.535657
Brydges CR, 2012, INTELLIGENCE, V40, P458, DOI 10.1016/j.intell.2012.05.006
Corsi PM, 1972, DISS ABSTR INT B, V34, P819
Cui JF, 2010, J AUTISM DEV DISORD, V40, P958, DOI 10.1007/s10803-010-0943-9
Davis AS, 2011, APPL NEUROPSYCHOL, V18, P61, DOI 10.1080/09084282.2010.523392
Dichter GS, 2010, J AUTISM DEV DISORD, V40, P448, DOI 10.1007/s10803-009-0886-1
Garcia-Molina A, 2010, REV NEUROLOGIA, V50, P738
GERSTADT CL, 1994, COGNITION, V53, P129, DOI 10.1016/0010-0277(94)90068-X
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Jones CRG, 2011, J AUTISM DEV DISORD, V41, P455, DOI 10.1007/s10803-010-1067-y
Kessels R P, 2000, Appl Neuropsychol, V7, P252, DOI 10.1207/S15324826AN0704_8
Kliegel M., 2002, PSYCHOL BEITR, V44, P303, DOI DOI 10.1037/0012-1649.44.2.612
Kvavilashvili L, 2001, DEV PSYCHOL, V37, P418, DOI 10.1037//0012-1649.37.3.418
Lee K, 2013, CHILD DEV, V84, P1933, DOI 10.1111/cdev.12096
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mackinlay R, 2006, BRAIN COGNITION, V61, P14, DOI 10.1016/j.bandc.2005.12.006
McDaniel M. A., 2007, PROSPECTIVE MEMORY O
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
PRIOR M, 1990, J AUTISM DEV DISORD, V20, P581, DOI 10.1007/BF02216063
SOMERVILLE SC, 1983, J GENET PSYCHOL, V143, P87
WILLIAMS D, 2013, CHEM IND-LONDON, V77, P43, DOI DOI 10.1007/S10803-012-1703-9
Yi L., 2012, AUTISM RES TREATMENT
Zelazo PD, 2006, NAT PROTOC, V1, P297, DOI 10.1038/nprot.2006.46
NR 31
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 654
EP 660
DI 10.1016/j.rasd.2014.03.005
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200007
ER
PT J
AU Salomone, E
Kutlu, B
Derbyshire, K
McCloy, C
Hastings, RP
Howlin, P
Charman, T
AF Salomone, Erica
Kutlu, Besterah
Derbyshire, Kayleigh
McCloy, Carlye
Hastings, Richard P.
Howlin, Patricia
Charman, Tony
TI Emotional and behavioural problems in children and young people with
autism spectrum disorder in specialist autism schools
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Mental health; Emotional and behavioural
problems; CAMHS; Service use
ID MENTAL-HEALTH PROBLEMS; DIFFICULTIES QUESTIONNAIRE; INTELLECTUAL
DISABILITY; PSYCHIATRIC-DISORDERS; ASPERGER-SYNDROME; AGE-CHILDREN;
PDD-NOS; ADOLESCENTS; STRENGTHS; IMPACT
AB We investigated emotional and behavioural problems in a sample (N = 615) of children and young people with autism spectrum disorders (ASD), most of whom also had intellectual disability (ID), attending specialist autism schools. High rates of parent- and teacher-reported problems were recorded. Teacher-reported levels of hyperactivity were higher in younger children. Teacher- but not parent-reported levels of conduct problems and hyperactivity were highest in children without phrase speech. Greater use of mental health services was associated with higher levels of emotional and behavioural problems, but only a minority of participants had accessed mental health services in the previous 6 months. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Salomone, Erica; Howlin, Patricia; Charman, Tony] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England.
[Kutlu, Besterah; Derbyshire, Kayleigh; McCloy, Carlye] Univ London, Inst Educ, Ctr Res Autism & Educ, London WC1N 1AZ, England.
[Hastings, Richard P.] Univ Warwick, Ctr Educ Dev Appraisal & Res, Coventry CV4 7AL, W Midlands, England.
RP Charman, T (reprint author), Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England.
EM tony.charman@kcl.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
Beck A, 2004, J INTELL DISABIL RES, V48, P628, DOI 10.1111/j.1365-2788.2003.00564.x
Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
Bryson SA, 2008, AUTISM, V12, P65, DOI 10.1177/1362361307085214
CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Dekker MC, 2003, J AM ACAD CHILD PSY, V42, P915, DOI 10.1097/01.CHI.0000046892.27264.1A
Einfeld SL, 2011, J INTELLECT DEV DIS, V36, P137, DOI 10.1080/13668250.2011.572548
Emerson E, 2003, J INTELL DISABIL RES, V47, P385, DOI 10.1046/j.1365-2788.2003.00498.x
Emerson E, 2005, J INTELLECT DEV DIS, V30, P14, DOI 10.1080/13668250500033169
Emerson E, 2010, SOC PSYCH PSYCH EPID, V45, P579, DOI 10.1007/s00127-009-0100-y
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gadow KD, 2009, J ATTEN DISORD, V12, P474, DOI 10.1177/1087054708320404
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
Goodman R, 1999, J ABNORM CHILD PSYCH, V27, P17, DOI 10.1023/A:1022658222914
Goodman R, 2003, INT REV PSYCHIATR, V15, P166, DOI 10.1080/0954026021000046128
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
Hastings RP, 2005, RES DEV DISABIL, V26, P456, DOI 10.1016/j.ridd.2004.10.003
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Horiuchi F., 2014, PSYCHIAT CLIN NEUROS
Howlin P., 2013, J CHILD PSYCHOL PSYC
Howlin P., 1998, J CHILD PSYCHOL PSYC, V39, P307
Iizuka C., 2010, BRAIN DEV, V32, P609
Jones AP, 2010, J AUTISM DEV DISORD, V40, P1094, DOI 10.1007/s10803-010-0957-3
Kaptein S, 2008, J INTELL DISABIL RES, V52, P125, DOI 10.1111/j.1365-2788.2007.00978.x
Karst JS, 2012, CLIN CHILD FAM PSYCH, V15, P247, DOI 10.1007/s10567-012-0119-6
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Levitt JM, 2007, J SCHOOL PSYCHOL, V45, P163, DOI 10.1016/j.jsp.2006.11.005
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Mandell DS, 2005, J AUTISM DEV DISORD, V35, P313, DOI 10.1007/s10803-005-3296-z
Meltzer H, 2000, MENTAL HLTH CHILDREN
Narendorf SC, 2011, PSYCHIAT SERV, V62, P975, DOI 10.1176/appi.ps.62.8.975
Osborne LA, 2011, RES AUTISM SPECT DIS, V5, P1253, DOI 10.1016/j.rasd.2011.01.016
Rosenthal R, 1991, METAANALYTIC PROCEDU
Rutter M., 2003, SCQ SOCIAL COMMUNICA
Simonoff E, 2013, J CHILD PSYCHOL PSYC, V54, P186, DOI 10.1111/j.1469-7610.2012.02606.x
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Snow AV, 2011, J AUTISM DEV DISORD, V41, P302, DOI 10.1007/s10803-010-1054-3
Szatmari P, 2003, J CHILD PSYCHOL PSYC, V44, P520, DOI 10.1111/1469-7610.00141
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
NR 47
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 661
EP 668
DI 10.1016/j.rasd.2014.03.004
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200008
ER
PT J
AU Radley, KC
O'Handley, RD
Ness, EJ
Ford, WB
Battaglia, AA
McHugh, MB
McLemore, CE
AF Radley, Keith C.
O'Handley, Roderick D.
Ness, Emily J.
Ford, W. Blake
Battaglia, Allison A.
McHugh, Melissa B.
McLemore, Chandler E.
TI Promoting social skill use and generalization in children with autism
spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Social skills; Generalization; Intervention
ID INTERVENTIONS; BEHAVIOR; METAANALYSIS; SCHOOL
AB Social skills training is a frequently utilized intervention for addressing social deficits of children with autism spectrum disorder (ASD). The current study investigated the effects of the Superheroes Social Skills program, a social skills training program consisting of multiple evidence-based practices, in promoting accurate demonstration of target social skills in both a training and generalized setting. Three children with ASD between the ages of 10 and 14 attended 10 social skills training sessions over five weeks, with social skills lessons targeting participation, conversation, perspective taking, and problem solving skills. A multiple probe design across behaviors and replicated across participants was utilized to evaluate accurate demonstration of target social skills. Results suggest improvement in skill accuracy in both the training and generalization settings. Indirect secondary measures of participant social functioning and parental stress were also collected and suggest improvements associated with social skills training. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Radley, Keith C.; O'Handley, Roderick D.; Ness, Emily J.; Ford, W. Blake; Battaglia, Allison A.; McHugh, Melissa B.; McLemore, Chandler E.] Univ So Mississippi, Dept Psychol, Hattiesburg, MS 39406 USA.
RP Radley, KC (reprint author), Univ So Mississippi, Dept Psychol, 118 Coll Dr 5025, Hattiesburg, MS 39406 USA.
EM keith.radley@usm.edu
CR Abidin RR, 1995, PARENTING STRESS IND
American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
Barry TD, 2003, J AUTISM DEV DISORD, V33, P685, DOI 10.1023/B:JADD.0000006004.86556.e0
Bellini S., 2007, FOCUS AUTISM OTHER D, V22, P80, DOI 10.1177/10883576070220020801
Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
Campbell A, 2011, J POSIT BEHAV INTERV, V13, P240, DOI 10.1177/1098300711400608
Carter A., 2005, HDB AUTISM PERVASIVE, P312
Cotugno AJ, 2009, J AUTISM DEV DISORD, V39, P1268, DOI 10.1007/s10803-009-0741-4
Doggett RA, 2013, J AUTISM DEV DISORD, V43, P2015, DOI 10.1007/s10803-012-1749-8
Elliott S., 2008, BEST PRACTICES IN SC, P1531
ELLIOTT SN, 1991, J SCHOOL PSYCHOL, V29, P43, DOI 10.1016/0022-4405(91)90014-I
Gagnon E., 2001, POWER CARDS USING SP
Ganz JB, 2012, BEHAV MODIF, V36, P378, DOI 10.1177/0145445512442214
Gast D., 2010, SINGLE SUBJECT RESEA
Goin-Kochel RP, 2007, RES AUTISM SPECT DIS, V1, P195, DOI 10.1016/j.rasd.2006.08.006
GRESHAM FM, 1987, J SPEC EDUC, V21, P167
Jenson W., 2011, SUPERHEROES SOCIAL S
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Miller R., 2014, RESEARCH IN AUTISM S, V8, P334
Parker RI, 2009, BEHAV THER, V40, P357, DOI 10.1016/j.beth.2008.10.006
Plavnick JB, 2013, EXCEPT CHILDREN, V80, P67
Radley K., 2014, FOCUS ON AUTISM AND
Radley KC, 2014, PSYCHOL SCHOOLS, V51, P241, DOI 10.1002/pits.21749
Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
STOKES TF, 1989, BEHAV THER, V20, P337, DOI 10.1016/S0005-7894(89)80054-1
Uebersax J S, 1982, J Psychiatr Res, V17, P335
Wang PS, 2009, EDUC TRAIN DEV DISAB, V44, P318
Yakubova Gulnoza, 2013, Journal of Special Education Technology, V28
NR 29
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 669
EP 680
DI 10.1016/j.rasd.2014.03.012
PG 12
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200009
ER
PT J
AU Chan, AS
Sze, SL
Han, YMY
AF Chan, Agnes S.
Sze, Sophia L.
Han, Yvonne M. Y.
TI An intranasal herbal medicine improves executive functions and activates
the underlying neural network in children with autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Herbal medicine; Executive functions; EEG; Prefrontal; Anterior
cingulate
ID INFERIOR FRONTAL-CORTEX; SPECTRUM DISORDERS; RESPONSE-INHIBITION;
ANTERIOR CINGULATE; RECTAL DIAZEPAM; OXYTOCIN; ATTENTION; BORNEOL;
BRAIN; INTERVENTIONS
AB Our animal and human studies have provided empirical evidence that a patented intranasal herbal medicine alters brain functions and neurophysiology. In particular, it reduces clinical symptoms and immunological anomalies in children with autism spectrum disorders (ASD). The present study explored whether the herbal formula can improve executive functions and the associated neuroelectrophysiological activity in ASD. Thirty children with ASD were evenly assigned to receive a daily intranasal administration of the herbal formula or no treatment. Their executive functions, behavioral problems, and electroencephalographic activity during an executive control task were measured before and after six months of treatment with the herbal formula. After treatment, the experimental group showed significantly improved inhibitory control, mental flexibility, and planning, which coincided with an event-related elevation in the activity of their prefrontal and anterior cingulate cortices (regions that are critical for executive control of behaviors) as well as reduced daily dysexecutive behaviors. In contrast, the control group showed no significant changes in executive functions or neural system activity. These findings support the administration of the intranasal herbal medicine as a possible intervention for improving executive functions in ASD. 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
C1 [Chan, Agnes S.; Sze, Sophia L.] Chinese Univ Hong Kong, Dept Psychol, Neuropsychol Lab, Shatin, Hong Kong, Peoples R China.
[Chan, Agnes S.; Sze, Sophia L.] Chinese Univ Hong Kong, Chanwuyi Res Ctr Neuropsychol Well Being, Shatin, Hong Kong, Peoples R China.
[Chan, Agnes S.] Henan Songshan Res Inst Chanwuyi, Chanwuyi 452470, Henan, Peoples R China.
[Han, Yvonne M. Y.] Hong Kong Inst Educ, Dept Special Educ & Counselling, Tai Po, Hong Kong, Peoples R China.
RP Chan, AS (reprint author), Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
EM aschan@psy.cuhk.edu.hk; lmsze@psy.cuhk.edu.hk; ymyhan@ied.edu.hk
CR Aman MG, 1997, J AUTISM DEV DISORD, V27, P342
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Anagnostou E, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-16
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Aron AR, 2004, TRENDS COGN SCI, V8, P170, DOI 10.1016/j.tics.2004.02.010
Asada H, 1999, NEUROSCI LETT, V274, P29, DOI 10.1016/S0304-3940(99)00679-5
Bossolasco P, 2012, INT J NANOMED, V7, P435, DOI 10.2147/IJN.S27537
Brickenkamp R, 1998, D2 TEST ATTENTION
Chambers CD, 2009, NEUROSCI BIOBEHAV R, V33, P631, DOI 10.1016/j.neubiorev.2008.08.016
Chan A. S., 2009, CASES J
Chan A. S., 2008, J PSYCHOL CHINESE SO, V9, P225
Chan A. S., 2013, CONT APPL SHAOLIN ME
Chan A. S., 2011, EVID-BASED COMPL ALT
Chan A. S., 2014, COMPREHENSIVE GUIDE, P2333
Chan A. S., 2010, SHAOLIN CHANWUYI CHI
Chan Agnes S, 2014, Front Aging Neurosci, V6, P50, DOI 10.3389/fnagi.2014.00050
Chan AS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068184
Chan A. S., 2013, EVIDENCE BASED COMPL
CHAN AS, 2011, EVID-BASED COMPL ALT, DOI DOI 10.1155/2011/180704
Chan AS, 2011, RES AUTISM SPECT DIS, V5, P254, DOI 10.1016/j.rasd.2010.04.007
Chan AS, 2012, J AFFECT DISORDERS, V142, P283, DOI 10.1016/j.jad.2012.05.018
CHAN AS, 2011, EVID-BASED COMPL ALT, P49254, DOI DOI 10.1155/2011/549254
CHAN AS, 2011, EVID-BASED COMPL ALT, P73961, DOI DOI 10.1093/ECAM/NEP043
Chan AS, 2012, EVID-BASED COMPL ALT, DOI 10.1155/2012/262136
Chan AS, 2012, SCI WORLD J, DOI 10.1100/2012/235206
Chapman CD, 2013, PHARM RES-DORDR, V30, P2475, DOI 10.1007/s11095-012-0915-1
Chen XH, 2010, J PHARM PHARMACOL, V62, P915, DOI [10.1211/jpp.62.05.0013, 10.1211/jpp.62.07.0013]
Conners C. K., 1997, CONNERS RATING SCALE
Craft S, 2012, ARCH NEUROL-CHICAGO, V69, P29, DOI 10.1001/archneurol.2011.233
Dadds M. R., 2013, J AUTISM DEV DISORDE
Danielyan L, 2011, REJUV RES, V14, P3, DOI 10.1089/rej.2010.1130
Delis D. C., 1997, DELIS KAPLAN EXECUTI
De Ridder D, 2011, NEUROSCI LETT, V496, P5, DOI 10.1016/j.neulet.2011.03.074
Djupesland Per Gisle, 2013, Drug Deliv Transl Res, V3, P42, DOI 10.1007/s13346-012-0108-9
Domes G, 2013, BIOL PSYCHIAT, V74, P164, DOI 10.1016/j.biopsych.2013.02.007
Dumpelmann M, 2012, HUM BRAIN MAPP, V33, P1172, DOI 10.1002/hbm.21276
Fisgin T, 2002, J CHILD NEUROL, V17, P123
FISH B, 1985, PSYCHOPHARMACOL BULL, V21, P753
Frazier TW, 2011, J CHILD ADOL PSYCHOP, V21, P571, DOI 10.1089/cap.2011.0057
Fuchs M, 2002, CLIN NEUROPHYSIOL, V113, P702, DOI 10.1016/S1388-2457(02)00030-5
Gioia GA, 2000, BEHAV RATING INVENTO
Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
Goin-Kochel RP, 2007, RES AUTISM SPECT DIS, V1, P195, DOI 10.1016/j.rasd.2006.08.006
Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
Han YMY, 2011, RES AUTISM SPECT DIS, V5, P486, DOI 10.1016/j.rasd.2010.06.013
Han YMY, 2013, RES AUTISM SPECT DIS, V7, P662, DOI 10.1016/j.rasd.2013.02.011
Hermens DF, 2005, PEDIATR NEUROL, V32, P248, DOI 10.1016/j.pediatrneurol.2004.11.009
Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
Holsti M, 2010, ARCH PEDIAT ADOL MED, V164, P747, DOI 10.1001/archpediatrics.2010.130
Huffman LC, 2011, J DEV BEHAV PEDIATR, V32, P56, DOI 10.1097/DBP.0b013e3182040acf
Ilium L., 2003, J CONTROL RELEASE, V87, P187
Jurcak V, 2007, NEUROIMAGE, V34, P1600, DOI 10.1016/j.neuroimage.2006.09.024
Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
Kenworthy L., 2013, J CHILD PSYCHOL PSYC
Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
Kiesel A, 2010, PSYCHOL BULL, V136, P849, DOI 10.1037/a0019842
Klem G H, 1999, Electroencephalogr Clin Neurophysiol Suppl, V52, P3
Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
Liu Q. D., 1994, GUANGZHOU ZHONGYIYAO, V11, P37
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P60, DOI 10.1016/j.rasd.2007.03.003
Murray M. L., 2013, PSYCHOPHARMACOLOGY
National Research Council, 2001, ED CHILDR AUT
Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
Pascual-Marqui RD, 2002, METHOD FIND EXP CLIN, V24, P5
Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
Sanders J, 2008, RES AUTISM SPECT DIS, V2, P1, DOI 10.1016/j.rasd.2007.03.005
Schioth HB, 2012, EXPERT REV CLIN PHAR, V5, P17, DOI [10.1586/ecp.11.70, 10.1586/ECP.11.70]
Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
Yu B, 2011, NEURAL REGEN RES, V6, P1876, DOI 10.3969/j.issn.1673-5374.2011.24.007
Yu B, 2013, J ETHNOPHARMACOL, V150, P1096, DOI 10.1016/j.jep.2013.10.028
Yu R. H., 2014, CLIN INTERV IN PRESS
NR 73
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 681
EP 691
DI 10.1016/j.rasd.2014.03.007
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200010
ER
PT J
AU Lin, JD
Lin, LP
Su, SF
Hsu, SW
Chou, YC
Lin, FG
Loh, CH
Wu, JL
Chu, CM
AF Lin, Jin-Ding
Lin, Lan-Ping
Su, Sheng-Fang
Hsu, Shang-Wei
Chou, Yu-Ching
Lin, Fu-Gong
Loh, Ching-Hui
Wu, Jia-Ling
Chu, Cordia M.
TI The interference of low back pain on everyday functions of life in care
workers for persons with intellectual, autistic, and associated multiple
disabilities: The Brief Pain Inventory short form (BPI-SF) survey
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Intellectual disability; Autism; Low back pain; Life interference; FACES
pain rating scale; BPI-SF
ID QUALITY-OF-LIFE; NECK PAIN; INSTITUTIONAL CAREGIVERS; SLEEP DISTURBANCE;
STAFF WORKING; HEALTH; PEOPLE; ADULTS; PREVALENCE; RISK
AB Low back pain is a critical public health problem; this condition significantly affects the quality of life and has a major socioeconomic impact. The present study aimed to investigate the interference of low back pain with everyday functions of life in disability care workers, and to examine the influencing factors of the interference, such as workers' demographic, lifestyle habits, self-reported health status, working conditions and previous pain experience. The Wong-Baker FACES Pain Rating Scale and Brief Pain Inventory Short Form were used to identify the pain severity and life interference of 677 participants who had experienced low back pain conditions in the previous year. The results indicated that the mean score of the pain severity was 3.78 +/- 1.82, 78.9% subjects experienced mild pain (score 2-4), 13.7% subjects experienced moderate pain, and 5.3% subjects experienced severe pain. More than twenty percent of the respondents reported that low back pain moderately or severely interfered with their daily functions. Many working conditions and pain experienced significantly correlated with the score of pain interference in the care workers after controlling for factors of healthy lifestyle and health status (R-2 = 41.7%). These findings may garner attention from health welfare authorities and lead to improvements in health promotion initiatives to prevent low back pain from interfering with the daily activities of care workers for people with intellectual, autistic and associated disabilities. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lin, Jin-Ding; Lin, Lan-Ping; Su, Sheng-Fang; Chou, Yu-Ching; Lin, Fu-Gong; Chu, Cordia M.] Natl Def Med Ctr, Sch Publ Hlth, Taipei 114, Taiwan.
[Lin, Jin-Ding; Wu, Jia-Ling] Chung Hua Fdn Persons Intellectual Disabil, New Taipei City, Taiwan.
[Lin, Jin-Ding; Chu, Cordia M.] Griffith Univ, Ctr Environm & Populat Hlth, Brisbane, Qld 4111, Australia.
[Hsu, Shang-Wei] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan.
[Hsu, Shang-Wei] China Med Univ, Dept Publ Hlth, Taichung, Taiwan.
[Loh, Ching-Hui] Taichung Armed Forces Gen Hosp, Taichung, Taiwan.
RP Lin, JD (reprint author), Natl Def Med Ctr, Sch Publ Hlth, 161,Minquan E Rd,Sect 6, Taipei 114, Taiwan.
EM a530706@ndmctsgh.edu.tw
CR Bardak AN, 2012, J REHABIL MED, V44, P858, DOI 10.2340/16501977-1043
Costa-Black KM, 2010, BEST PRACT RES CL RH, V24, P227, DOI 10.1016/j.berh.2009.11.007
DAUT RL, 1983, PAIN, V17, P197, DOI 10.1016/0304-3959(83)90143-4
Eadie J, 2013, ARCH PHYS MED REHAB, V94, P2083, DOI 10.1016/j.apmr.2013.04.017
Fernandez-de-las-Penas C, 2011, SPINE, V36, pE213, DOI 10.1097/BRS.0b013e3181d952c2
GARG A, 1992, OCCUP MED, V7, P593
Hatton C, 1999, RES DEV DISABIL, V20, P269, DOI 10.1016/S0891-4222(99)00009-8
Hestbaek L, 2003, J MANIP PHYSIOL THER, V26, P243, DOI 10.1016/S0161-4754(03)00003-4
Hsu SW, 2014, RES DEV DISABIL, V35, P364, DOI 10.1016/j.ridd.2013.11.011
Hsu SW, 2012, RES DEV DISABIL, V33, P615, DOI 10.1016/j.ridd.2011.09.005
Hu J, 2010, J INTELLECT DEV DIS, V35, P29, DOI 10.3109/13668250903501499
Iglesias-Gonzalez JJ, 2013, PAIN MED, V14, P1964, DOI 10.1111/pme.12224
Karp JF, 2014, ARCH PHYS MED REHAB, V95, P309, DOI 10.1016/j.apmr.2013.09.007
Kelly GA, 2011, CLIN J PAIN, V27, P169, DOI 10.1097/AJP.0b013e3181f3bdd5
Lai CI, 2011, RES DEV DISABIL, V32, P1226, DOI 10.1016/j.ridd.2010.12.024
LARSON SA, 1992, MENT RETARD, V30, P13
Leijon O, 2009, OCCUP ENVIRON MED, V66, P137, DOI 10.1136/oem.2008.040337
Lin LP, 2013, RES AUTISM SPECT DIS, V7, P777, DOI 10.1016/j.rasd.2013.03.004
Lin JD, 2009, RES DEV DISABIL, V30, P1448, DOI 10.1016/j.ridd.2009.07.005
Lin JD, 2013, RES DEV DISABIL, V34, P3211, DOI 10.1016/j.ridd.2013.06.044
Lin JD, 2009, RES DEV DISABIL, V30, P146, DOI 10.1016/j.ridd.2008.02.001
Lin JD, 2014, RES AUTISM SPECT DIS, V8, P509, DOI 10.1016/j.rasd.2014.01.013
Lin JD, 2014, RES DEV DISABIL, V35, P178, DOI 10.1016/j.ridd.2013.10.008
Lin JD, 2013, RES DEV DISABIL, V34, P2127, DOI 10.1016/j.ridd.2013.03.034
Lin JD, 2009, RES DEV DISABIL, V30, P538, DOI 10.1016/j.ridd.2008.08.002
Lin LP, 2013, RES AUTISM SPECT DIS, V7, P1625, DOI 10.1016/j.rasd.2013.09.003
Lin LP, 2011, RES DEV DISABIL, V32, P1589, DOI 10.1016/j.ridd.2011.01.057
Lin LP, 2013, RES DEV DISABIL, V34, P4559, DOI 10.1016/j.ridd.2013.09.038
Matsui H, 1997, SPINE, V22, P1242, DOI 10.1097/00007632-199706010-00014
Ministry of the Interiors, 2013, COND WELF SERV I DIS
Morin CM, 1998, CLIN J PAIN, V14, P311, DOI 10.1097/00002508-199812000-00007
Mork P. J., 2013, EUROPEAN J PUBLIC HL
Muraki S, 2011, SPINE, V36, P1312, DOI 10.1097/BRS.0b013e3181fa60d1
O'Donoghue GM, 2009, BMC MUSCULOSKEL DIS, V10, DOI 10.1186/1471-2474-10-122
Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
Pedisic Z, 2013, J MANIP PHYSIOL THER, V36, P267, DOI 10.1016/j.jmpt.2013.05.012
Ropponen A, 2012, J PSYCHOSOM RES, V73, P289, DOI 10.1016/j.jpsychores.2012.07.003
Rose J, 2003, J APPL RES INTELLECT, V16, P267, DOI 10.1046/j.1468-3148.2003.00168.x
Schulz R, 1999, JAMA-J AM MED ASSOC, V282, P2215, DOI 10.1001/jama.282.23.2215
SCHULZ R, 1995, GERONTOLOGIST, V35, P771
Seoud J, 2007, INT J NURS STUD, V44, P259, DOI 10.1016/j.ijnurstu.2005.11.034
Soysal M, 2013, TURK NEUROSURG, V23, P75, DOI 10.5137/1019-5149.JTN.6885-12.0
Strine TW, 2007, ARTHRIT RHEUM-ARTHR, V57, P656, DOI 10.1002/art.22684
Tella BA, 2013, INT J OCCUP MED ENV, V26, P621, DOI 10.2478/s13382-013-0135-x
Veresciagina K, 2007, MED LITH, V43, P607
Williams LJ, 2012, J PSYCHOSOM RES, V72, P452, DOI 10.1016/j.jpsychores.2012.03.001
Wong D. L., 2001, WONG BAKER FACES PAI, V6/e
Yalcinkaya EY, 2010, TOP STROKE REHABIL, V17, P389, DOI 10.1310/tsr1705-389
Yen CF, 2009, CURR OPIN PSYCHIATR, V22, P447, DOI 10.1097/YCO.0b013e328329713d
Yen CF, 2009, RES DEV DISABIL, V30, P1354, DOI 10.1016/j.ridd.2009.06.002
NR 50
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 692
EP 700
DI 10.1016/j.rasd.2014.03.011
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200011
ER
PT J
AU Carrington, SJ
Kent, RG
Maljaars, J
Le Couteur, A
Gould, J
Wing, L
Noens, I
Van Berckelaer-Onnes, I
Leekam, SR
AF Carrington, Sarah J.
Kent, Rachel G.
Maljaars, Jarymke
Le Couteur, Ann
Gould, Judith
Wing, Lorna
Noens, Ilse
Van Berckelaer-Onnes, Ina
Leekam, Susan R.
TI DSM-5 Autism Spectrum Disorder: In search of essential behaviours for
diagnosis
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; DSM-5; Abbreviated; Diagnosis; DISCO
ID PERVASIVE DEVELOPMENTAL DISORDERS; COMMUNICATION DISORDERS; IV-TR;
SHORT-FORM; CRITERIA; INTERVIEW; CHILDREN; SPECIFICITY; SENSITIVITY;
VALIDATION
AB The objective of this study was to identify a set of 'essential' behaviours sufficient for diagnosis of DSM-5 Autism Spectrum Disorder (ASD). Highly discriminating, 'essential' behaviours were identified from the published DSM-5 algorithm developed for the Diagnostic Interview for Social and Communication Disorders (DISCO). Study 1 identified a reduced item set (48 items) with good predictive validity (as measured using receiver operating characteristic curves) that represented all symptom sub-domains described in the DSM-5 ASD criteria but lacked sensitivity for individuals with higher ability. An adjusted essential item set (54 items; Study 2) had good sensitivity when applied to individuals with higher ability and performance was comparable to the published full DISCO DSM-5 algorithm. Investigation at the item level revealed that the most highly discriminating items predominantly measured social-communication behaviours. This work represents a first attempt to derive a reduced set of behaviours for DSM-5 directly from an existing standardised ASD developmental history interview and has implications for the use of DSM-5 criteria for clinical and research practice. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
C1 [Carrington, Sarah J.; Kent, Rachel G.; Leekam, Susan R.] Cardiff Univ, Sch Psychol, Wales Autism Res Ctr, Cardiff CF10 3AX, S Glam, Wales.
[Maljaars, Jarymke; Noens, Ilse] Univ Leuven KU Leuven, Louvain, Belgium.
[Maljaars, Jarymke; Van Berckelaer-Onnes, Ina] Leiden Univ, NL-2300 RA Leiden, Netherlands.
[Le Couteur, Ann] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Gould, Judith; Wing, Lorna] Natl Autist Soc, Lorna Wing Ctr, Bromley, England.
RP Carrington, SJ (reprint author), Sch Psychol, Wales Autism Res Ctr, Tower Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales.
EM carringtonsj@cardiff.ac.uk
RI Carrington, Sarah/C-1246-2010
OI Carrington, Sarah/0000-0001-5548-8793
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
American Psychiatric Association, 2011, DSM 5 DEV 299 00 AUT
Baranek GT, 2013, DEV PSYCHOPATHOL, V25, P307, DOI 10.1017/S0954579412001071
Barton ML, 2013, J AUTISM DEV DISORD, V43, P1184, DOI 10.1007/s10803-013-1817-8
Bayley N, 1993, BAYLEY SCALES INFANT
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Gibbs V, 2012, J AUTISM DEV DISORD, V42, P1750, DOI 10.1007/s10803-012-1560-6
Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
Gillberg C., 2000, AUTISM, V4, P11, DOI 10.1177/1362361300004001002
Hosmer DW, 2000, APPL LOGISTIC REGRES, V2nd
Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
Kent RG, 2013, J CHILD PSYCHOL PSYC, V54, P1242, DOI 10.1111/jcpp.12085
Kulage K. M., 2014, J AUTISM DEV DISORDE
Leekam SR, 2002, J CHILD PSYCHOL PSYC, V43, P327, DOI 10.1111/1469-7610.00024
Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
Leiter R. G., 1979, LEITER INT PERFORMAN
Liu CC, 2013, SCHIZOPHR RES, V143, P32, DOI 10.1016/j.schres.2012.10.042
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Maljaars J, 2012, AUTISM, V16, P487, DOI 10.1177/1362361311402857
Matson JL, 2012, J AUTISM DEV DISORD, V42, P1549, DOI 10.1007/s10803-012-1582-0
Matson JL, 2012, J DEV PHYS DISABIL, V24, P403, DOI 10.1007/s10882-012-9278-0
Matson JL, 2007, RES AUTISM SPECT DIS, V1, P38, DOI 10.1016/j.rasd.2006.07.004
Matson JL, 2012, DEV NEUROREHABIL, V15, P185, DOI 10.3109/17518423.2012.672341
Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P298, DOI 10.1016/j.rasd.2012.08.011
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
Nunnally J. C., 1994, PSYCHOMETRIC THEORY
Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
Rodi M. L., 2013, J AUTISM DEV DISORD, V44, P758
Rutter M., 2003, SOCIAL COMMUNICATION
Santosh PJ, 2009, EUR CHILD ADOLES PSY, V18, P521, DOI 10.1007/s00787-009-0004-0
Smith GT, 2000, PSYCHOL ASSESSMENT, V12, P102, DOI 10.1037//1040-3590.12.1.102
Tellegen PJ, 1998, SNIJDERS OOMEN NONVE
Wilson CE, 2013, J AUTISM DEV DISORD, V43, P2515, DOI 10.1007/s10803-013-1799-6
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
Worley JA, 2012, RES AUTISM SPECT DIS, V6, P965, DOI 10.1016/j.rasd.2011.12.012
NR 38
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 701
EP 715
DI 10.1016/j.rasd.2014.03.017
PG 15
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200012
ER
PT J
AU Boonen, H
Maljaars, J
Lambrechts, G
Zink, I
Van Leeuwen, K
Noens, I
AF Boonen, Hannah
Maljaars, Jarymke
Lambrechts, Greet
Zink, Inge
Van Leeuwen, Karla
Noens, Ilse
TI Behavior problems among school-aged children with autism spectrum
disorder: Associations with children's communication difficulties and
parenting behaviors
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Externalizing behavior problems; Internalizing
behavior problems; Communication difficulties; Parenting behaviors
ID EMOTIONAL-PROBLEMS; PSYCHOMETRIC PROPERTIES; CONDUCT PROBLEMS;
EARLY-CHILDHOOD; MENTAL-HEALTH; STRESS; QUESTIONNAIRE; STRENGTHS;
LANGUAGE; ADOLESCENTS
AB Research has clearly demonstrated that behavior problems are common among children with ASD. These co-occurring behavior problems place children with ASD and their families at risk for a range of negative outcomes. This questionnaire study aimed to investigate whether and how age, gender, and communication difficulties at the child level and parenting behaviors at the family level are associated with externalizing and internalizing problems among children with ASD (n = 206) and without ASD (n = 187) aged 6-12 years. Results indicated that pragmatic language difficulties of the child and negative controlling parenting behaviors both made a significant and unique contribution to externalizing behavior problems for the ASD group. In the control group, chronological age and pragmatic language difficulties were the most robust concurrent predictors of externalizing problems. With regard to internalizing problems, pragmatic language difficulties and ASD adapted parenting behaviors were significant predictors for both the ASD and control group. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Boonen, Hannah; Maljaars, Jarymke; Lambrechts, Greet; Van Leeuwen, Karla; Noens, Ilse] Katholieke Univ Leuven, Parenting & Special Educ Res Unit, B-3000 Louvain, Belgium.
[Boonen, Hannah; Maljaars, Jarymke; Lambrechts, Greet; Noens, Ilse] Katholieke Univ Leuven, Leuven Autism Res, B-3000 Louvain, Belgium.
[Zink, Inge] Katholieke Univ Leuven, Dept Neurosci, ExpORL, B-3000 Louvain, Belgium.
RP Boonen, H (reprint author), Katholieke Univ Leuven, Parenting & Special Educ Res Unit, Leopold Vanderkelesntr 32,Box 3765, B-3000 Louvain, Belgium.
EM Hannah.Boonen@ppw.kuleuven.be
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Barber Brian K, 2005, Monogr Soc Res Child Dev, V70, P1
Bauminger N, 2010, AUTISM RES, V3, P101, DOI 10.1002/aur.131
Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
Boonen H, 2014, RES AUTISM SPECT DIS, V8, P716, DOI 10.1016/j.rasd.2014.03.008
Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
Calkins S D, 1994, Monogr Soc Res Child Dev, V59, P53, DOI 10.2307/1166138
Calkins SD, 2002, DEV PSYCHOPATHOL, V14, P477, DOI 10.1017/S0954579402003057
Calkins SD, 2007, DEV PSYCHOPATHOL, V19, P675, DOI 10.1017/S095457940700034X
Caron A, 2006, J CLIN CHILD ADOLESC, V35, P34, DOI 10.1207/s15374424jccp3501_4
Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634
Coplan RJ, 2009, INFANT CHILD DEV, V18, P238, DOI 10.1002/icd.622
De Pauw SSW, 2011, J AUTISM DEV DISORD, V41, P196, DOI 10.1007/s10803-010-1043-6
Dionne G, 2003, DEV PSYCHOL, V39, P261, DOI 10.1037/0012-1649.39.2.261
Dominick KC, 2007, RES DEV DISABIL, V28, P145, DOI 10.1016/j.ridd.2006.02.003
Estes A, 2013, BRAIN DEV-JPN, V35, P133, DOI 10.1016/j.braindev.2012.10.004
Fagan J., 2000, EARLY EDUC DEV, V11, P307, DOI [10.1207/s15566935eed1103_5, DOI 10.1207/S15566935EED1103_5]
Field A., 2009, DISCOVERING STAT USI
Finkenauer C, 2005, INT J BEHAV DEV, V29, P58, DOI 10.1080/01650250444000333
Gavidia-Payne S, 2002, J INTELLECT DEV DIS, V27, P31
Geurts H. M., 2007, CCC 2 NL CHILDR COMM
Goodman A, 2009, J AM ACAD CHILD PSY, V48, P400, DOI 10.1097/CHI.0b013e3181985068
Goodman A, 2010, J ABNORM CHILD PSYCH, V38, P1179, DOI 10.1007/s10802-010-9434-x
Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Gray K, 2012, AJIDD-AM J INTELLECT, V117, P121, DOI 10.1352/1944-7588-117-2.121
Hartas D, 2011, OXFORD REV EDUC, V37, P763, DOI 10.1080/03054985.2011.636226
Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
Kawabata Y, 2011, DEV REV, V31, P240, DOI 10.1016/j.dr.2011.08.001
Lahey BB, 2000, J ABNORM PSYCHOL, V109, P488, DOI 10.1037//0021-843X.109.3.488
Lambrechts G, 2011, RES AUTISM SPECT DIS, V5, P1143, DOI 10.1016/j.rasd.2010.12.011
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Maljaars J, 2014, J AUTISM DEV DISORD, V44, P501, DOI 10.1007/s10803-013-1894-8
Matson JL, 2007, RES AUTISM SPECT DIS, V1, P28, DOI 10.1016/j.rasd.2006.07.003
Matson JL, 2010, RES AUTISM SPECT DIS, V4, P400, DOI 10.1016/j.rasd.2009.10.010
Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
McStay R. L., 2013, AUTISM
McTiernan A, 2011, RES AUTISM SPECT DIS, V5, P1215, DOI 10.1016/j.rasd.2011.01.009
Midouhas E, 2013, J AM ACAD CHILD PSY, V52, P1057, DOI 10.1016/j.jaac.2013.07.011
Muris P, 2003, EUR CHILD ADOLES PSY, V12, P1, DOI 10.1007/s00787-003-0298-2
Noens I., 2013, PARENTAL BEHAV SCALE
Osborne LA, 2008, RES AUTISM SPECT DIS, V2, P249, DOI 10.1016/j.rasd.2007.06.004
Park CJ, 2012, J AUTISM DEV DISORD, V42, P2761, DOI 10.1007/s10803-012-1534-8
Patterson G., 1982, COERCIVE FAMILY PROC, V3
Patterson G. R., 1992, ANTISOCIAL BOYS SOCI, V4
PETTIT GS, 1993, SCHOOL PSYCHOL REV, V22, P403
Reid J. B., 2002, ANTISOCIAL BEHAV CHI
Repp A. C., 1999, FUNCTIONAL ANAL PROB
Sikora D, 2013, RES AUTISM SPECT DIS, V7, P307, DOI 10.1016/j.rasd.2012.09.006
Smith CL, 2004, DEV PSYCHOL, V40, P29, DOI 10.1037/0012-1649.40.1.29
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
Tremblay RE, 2000, INT J BEHAV DEV, V24, P129
Van Leeuwen KG, 2004, EUR J PSYCHOL ASSESS, V20, P283, DOI 10.1027/1015-5759.20.4.283
Vermulst A., 2010, HANDLEIDING BI UNPUB
Wood JJ, 2003, J CHILD PSYCHOL PSYC, V44, P134, DOI 10.1111/1469-7610.00106
NR 60
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 716
EP 725
DI 10.1016/j.rasd.2014.03.008
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200013
ER
PT J
AU Tzanakaki, P
Grindle, CF
Dungait, S
Hulson-Jones, A
Saville, M
Hughes, JC
Hastings, RP
AF Tzanakaki, Pagona
Grindle, Corinna F.
Dungait, Sarah
Hulson-Jones, Amy
Saville, Maria
Hughes, J. Carl
Hastings, Richard P.
TI Use of a tactile prompt to increase social initiations in children with
autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Social interaction; Initiations
ID INTERVENTION; PRESCHOOLERS; TEENAGERS; STUDENTS; SKILLS; PEERS
AB Making appropriate verbal initiations to others is an aspect of social interaction that can be problematic for individuals with autism. A variety of teaching and prompting methods have been developed to address the issue including the use of a tactile prompt, a small device that can fit in the participant's pocket and can be programmed to vibrate at regular intervals. Our aim was to extend the existing research on the use of the tactile prompt by incorporating reinforcement during intervention and attempting a systematic fading of the prompt. Three children with autism participated in Study 1 and two children in Study 2. In both studies, the intervention was conducted during free-play activities with mainstream peers. Results indicated that the participants' verbal initiations to their peers increased in comparison to baseline. Additionally in Study 2, the use of both the tactile prompt and the prosthetic reinforcement were successfully faded. Implications regarding the use of covert prompting methods to help individuals with autism in the area of social interactions are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Tzanakaki, Pagona; Grindle, Corinna F.; Dungait, Sarah; Hulson-Jones, Amy; Saville, Maria; Hughes, J. Carl; Hastings, Richard P.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
RP Tzanakaki, P (reprint author), 11 Nafpliou Str, Athens 13461, Greece.
EM pagonatzanakaki@hotmail.com
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT, V5
Anglesea MM, 2008, J APPL BEHAV ANAL, V41, P107, DOI 10.1901/jaba.2008.41-107
Anson HM, 2008, BEHAV RES METHODS, V40, P1106, DOI 10.3758/BRM.40.4.1106
Cooper J. O., 2007, APPL BEHAV ANAL
GREENWOOD C R, 1981, Journal of Pediatric Psychology, V6, P343, DOI 10.1093/jpepsy/6.4.343
Grindle C. F., 2009, ED CHILD PSYCHOL, V26, P65, DOI DOI 10.1007/S10803-011-1234-9
Grindle CF, 2012, BEHAV MODIF, V36, P298, DOI 10.1177/0145445512441199
Hauk M., 1995, J AUTISM DEV DISORD, V25, P579
KAMPS DM, 1992, J APPL BEHAV ANAL, V25, P281, DOI 10.1901/jaba.1992.25-281
Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P186, DOI 10.2511/rpsd.24.3.186
Koegel LK, 2001, BEHAV MODIF, V25, P745, DOI 10.1177/0145445501255005
Koegel R. L., 2006, PIVOTAL RESPONSE TRE
Koegel RL, 2001, J CLIN CHILD PSYCHOL, V30, P19, DOI 10.1207/S15374424JCCP3001_4
KRANTZ PJ, 1993, J APPL BEHAV ANAL, V26, P121, DOI 10.1901/jaba.1993.26-121
McGrath AM, 2003, J POSIT BEHAV INTERV, V5, P47, DOI 10.1177/10983007030050010701
Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x
Nikopoulos CK, 2003, BEHAV INTERVENT, V18, P87, DOI 10.1002/bin.129
ODOM SL, 1985, J APPL BEHAV ANAL, V18, P3, DOI 10.1901/jaba.1985.18-3
Oke J. N., 1990, J AUTISM DEV DISORD, V20, P479
Shabani DB, 2002, J APPL BEHAV ANAL, V35, P79, DOI 10.1901/jaba.2002.35-79
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Sulzer-Azaroff B., 1991, BEHAV ANAL LASTING C
Swaggart B. L., 1995, FOCUS AUTISTIC BEHAV, V10, P1
Taylor BA, 1998, J APPL BEHAV ANAL, V31, P651, DOI 10.1901/jaba.1998.31-651
Taylor BA, 2004, J APPL BEHAV ANAL, V37, P79, DOI 10.1901/jaba.2004.37-79
Thorndike R. L., 1986, STALFORD BINET INTEL
TREMBLAY A, 1981, BEHAV MODIF, V5, P237, DOI 10.1177/014544558152006
Weiss MJ, 2001, BEHAV MODIF, V25, P785, DOI 10.1177/0145445501255007
Zanolli K, 1996, J AUTISM DEV DISORD, V26, P407, DOI 10.1007/BF02172826
NR 29
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUN
PY 2014
VL 8
IS 6
BP 726
EP 736
DI 10.1016/j.rasd.2014.03.016
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AH4PT
UT WOS:000336111200014
ER
PT J
AU Malakar, S
Bhattacharya, S
AF Malakar, S.
Bhattacharya, S.
TI MINDING THE GREENS: ROLE OF DIETARY SALICYLATES IN COMMON BEHAVIOURAL
HEALTH CONDITIONS
SO ACTA ALIMENTARIA
LA English
DT Article
DE naturally occurring salicylates; diet; ADHD; autism; depression;
schizophrenia
ID DEFICIT HYPERACTIVITY DISORDER; FOLLOW-UP; DOUBLE-BLIND; CLINICAL
PHARMACOKINETICS; FEINGOLD HYPOTHESIS; CONTROLLED-TRIAL; FOOD-ADDITIVES;
FATTY-ACIDS; CHILDREN; SCHIZOPHRENIA
AB The role of artificial food additives and food chemicals in abetting certain behavioural conditions has been the subject of behavioural nutrition research over several decades. However, a few studies have also raised questions regarding a similar role possibly played by naturally occurring phytochemicals in general and salicylates in particular. Such studies have, however, been rather few and far between. More importantly, till date, there has been no attempt to collate the findings from the few studies that have been carried out at different points in time by different researchers across different countries and cultures. This gap in the extant body of knowledge is made especially prominent by the fact that naturally occurring salicylates abound in many green vegetables and fruit, which are common constituents of a healthy diet. The aim of this review article is two-fold - firstly, to collate and present the related researches on the effects of salicylates in general and natural salicylates in particular on mental health; and secondly, to identify promising research directions for the future.
C1 [Malakar, S.] Monash Univ, Cent Clin Sch, Alfred Ctr, Dept Gastroenterol, Melbourne, Vic 3004, Australia.
[Bhattacharya, S.] Deakin Univ, Deakin Grad Sch Business, Burwood, Vic 3125, Australia.
RP Bhattacharya, S (reprint author), Deakin Univ, Deakin Grad Sch Business, 221 Burwood Highway, Burwood, Vic 3125, Australia.
EM sukanto@deakin.edu.au
CR Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
Alberti A, 1999, BIOL PSYCHIAT, V46, P420, DOI 10.1016/S0006-3223(98)00337-0
Am Amani R., 2005, J IRAN U MED SCI, V12, P37
Biederman J, 2010, AM J PSYCHIAT, V167, P409, DOI 10.1176/appi.ajp.2009.09050736
Biederman J, 2006, PSYCHOL MED, V36, P167, DOI 10.1017/S0033291705006410
Bosetti C, 2002, EUR J CANCER PREV, V11, P535, DOI 10.1097/00008469-200212000-00005
BROWNELL KD, 1995, BEHAV MED, V20, P155
Clarke L., 1996, Australian Journal of Nutrition and Dietetics, V53, P89
CONNERS CK, 1976, PEDIATRICS, V58, P154
COSMAN MP, 1983, ANNU REV NUTR, V3, P1, DOI 10.1146/annurev.nu.03.070183.000245
DAVIES NM, 1995, CLIN PHARMACOKINET, V28, P100
Deakin JFW, 1997, J PSYCHOPHARMACOL, V11, P133, DOI 10.1177/026988119701100206
Dengate C., 2009, AUSTR CERTIFIED AUT, V2009, P22
DOHAN FC, 1966, ACTA PSYCHIAT SCAND, V42, P125, DOI 10.1111/j.1600-0447.1966.tb01920.x
Edwards R, 1998, J AFFECT DISORDERS, V48, P149, DOI 10.1016/S0165-0327(97)00166-3
Emond A., 2010, PEDIATRICS, V126, P337, DOI DOI 10.1542/PEDS.2009-2391
Faraone SV, 2006, PSYCHOL MED, V36, P159, DOI 10.1017/S003329170500471X
Feingold B F, 1975, Am J Nurs, V75, P797, DOI 10.2307/3423460
FEINGOLD BF, 1979, J NEURAL TRANSM, V45, P107, DOI 10.1007/BF01250086
Feingold B.F., 1973, AMA SECTION ALLERGY
Fernell E, 2007, NEUROSCI LETT, V418, P82, DOI 10.1016/j.neulet.2007.03.004
FITZSIMON M, 1978, MED J AUSTRALIA, V2, P570
Flint-Hamilton KB, 1999, HESPERIA, V68, P371, DOI 10.2307/148493
Garfield E, 1985, ESSAYS INFORM SCI, V8, P392
Ghalioungui P., 1977, FOOD GIFT OSIRIS
Good P, 2009, ALTERN MED REV, V14, P364
Goodman L.S., 1965, PHARM BASIS THERAPEU
Grohol J, 2010, ASPIRIN SCHIZOPHRENI
Grohol J, 2010, WHAT DO GIRLS ADHD L
GROSS MD, 1987, J AM ACAD CHILD PSY, V26, P53, DOI 10.1097/00004583-198701000-00011
Hamdan TA, 2008, J AM ACAD ORTHOP SUR, V16, P41
HARLEY JP, 1978, PEDIATRICS, V61, P818
HIBBELN JR, 1995, AM J CLIN NUTR, V62, P1
Jeffreys D, 2004, ASPIRIN STORY WONDER
KANAREK RB, 1986, NUTR REV, V44, P172
Gray PEA, 2013, MED J AUSTRALIA, V198, P600, DOI 10.5694/mja12.11255
KAVALE KA, 1983, J LEARN DISABIL, V16, P324
KING DS, 1981, BIOL PSYCHIAT, V16, P3
Kraft B.D., 2009, NUTR METAB, V6, P1
Laan W, 2010, J CLIN PSYCHIAT, V71, P520, DOI 10.4088/JCP.09m05117yel
Lennox WG, 1928, ARCH NEURO PSYCHIATR, V20, P771
Lucas M, 2011, AM J CLIN NUTR, V93, P1337, DOI 10.3945/ajcn.111.011817
McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P45, DOI 10.1192/bjp.183.1.45
McCreadie RG, 2005, BRIT J PSYCHIAT, V187, P346, DOI 10.1192/bjp.187.4.346
Moscandrew M, 2009, INFLAMM BOWEL DIS, V15, P1399, DOI 10.1002/ibd.20944
Mukherjee R, 2007, INDIAN J TRADIT KNOW, V6, P432
Murphy S.P., 2003, AM J CLIN NUTR, V78, P827
Nabin M.H., 2013, J INTERDISCIPL MATH, V16, P83
NEEDS CJ, 1985, CLIN PHARMACOKINET, V10, P164, DOI 10.2165/00003088-198510020-00004
NESTLE M, 1995, AM J CLIN NUTR, V61, p1313S
PAOLETTI R, 1975, ANNU REV PHARMACOL, V15, P73, DOI 10.1146/annurev.pa.15.040175.000445
Parker G, 2002, AUST NZ J PSYCHIAT, V36, P263, DOI 10.1046/j.1440-1614.2002.00978.x
Patel K, 2007, J ALTERN COMPLEM MED, V13, P1091, DOI 10.1089/acm.2007.0611
Paterson JR, 2006, J AGR FOOD CHEM, V54, P2891, DOI 10.1021/jf058158w
Paterson JR, 2001, QJM-MON J ASSOC PHYS, V94, P445, DOI 10.1093/qjmed/94.8.445
Paterson JR, 2008, J AGR FOOD CHEM, V56, P11648, DOI 10.1021/jf800974z
Perry CA, 1996, NUTR REV, V54, P225
Pierpoint WS, 2002, ANN APPL BIOL, V140, P233, DOI 10.1111/j.1744-7348.2002.tb00176.x
Reichelt K.L., 2012, OPEN J PSYCHIAT, V2, P12
RIMLAND B, 1983, J LEARN DISABIL, V16, P331
ROBINSON MHE, 1995, DIGEST DIS SCI, V40, P315, DOI 10.1007/BF02065416
Rojas NL, 2005, MENT RETARD DEV D R, V11, P116, DOI 10.1002/mrdd.20064
Sanchez-Villegas A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016268
Shannon WR, 1922, AM J DIS CHILD, V24, P89
Soh NL, 2009, ACTA NEUROPSYCHIATR, V21, P214, DOI 10.1111/j.1601-5215.2009.00413.x
Solomon J.A., 2010, MINDING OUR BODIES
Sorensen HJ, 2004, BRIT J PSYCHIAT, V185, P366, DOI 10.1192/bjp.185.5.366
Srinivasan P, 2009, ANN CLIN PSYCHIATRY, V21, P237
Stevens LJ, 2011, CLIN PEDIATR, V50, P279, DOI 10.1177/0009922810384728
SWAIN AR, 1985, J AM DIET ASSOC, V85, P950
Venema DP, 1996, J AGR FOOD CHEM, V44, P1762, DOI 10.1021/jf950458y
Walker JR, 2008, AM J GASTROENTEROL, V103, P1989, DOI 10.1111/j.1572-0241.2008.01980.x
Waring R. H., 2000, Journal of Nutritional and Environmental Medicine (Abingdon), V10, P25, DOI 10.1080/13590840050000861
WENDER EH, 1986, J DEV BEHAV PEDIATR, V7, P35, DOI 10.1097/00004703-198602000-00007
STARE FJ, 1980, PEDIATRICS, V66, P521
NR 75
TC 0
Z9 0
PU AKADEMIAI KIADO RT
PI BUDAPEST
PA PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY
SN 0139-3006
EI 1588-2535
J9 ACTA ALIMENT HUNG
JI Acta Aliment.
PD JUN
PY 2014
VL 43
IS 2
BP 344
EP 356
DI 10.1556/AAlim.2014.0017
PG 13
WC Food Science & Technology; Nutrition & Dietetics
SC Food Science & Technology; Nutrition & Dietetics
GA AH4IS
UT WOS:000336091200019
ER
PT J
AU Ndika, JDT
Martinez-Munoz, C
Anand, N
van Dooren, SJM
Kanhai, W
Smith, DEC
Jakobs, C
Salomons, GS
AF Ndika, Joseph D. T.
Martinez-Munoz, Cristina
Anand, Nandaja
van Dooren, Silvy J. M.
Kanhai, Warsha
Smith, Desiree E. C.
Jakobs, Cornelis
Salomons, Gajja S.
TI Post-transcriptional regulation of the creatine transporter gene:
Functional relevance of alternative splicing
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Article
DE Na+ /Cl- cotransporter; Creatine transporter; Alternative splicing;
Creatine uptake upregulation; Intellectual disability
ID UBIQUITIN LIGASE NEDD4-2; EPITHELIAL NA+ CHANNEL; NEUROTRANSMITTER
TRANSPORTERS; MESSENGER-RNA; INBORN ERROR; KINASES SGK1; SERUM; RAT;
SUPPLEMENTATION; DEFICIENCY
AB Background: Aberrations in about 10-15% of X-chromosome genes account for intellectual disability (ID); with a prevalence of 1-3% (Gecz et al., 2009 [1]). The SLC6A8 gene, mapped to Xq28, encodes the creatine transporter (CTR1). Mutations in SLC6A8, and the ensuing decrease in brain creatine, lead to co-occurrence of speech/language delay, autism-like behaviors and epilepsy with ID. A splice variant of SLC6A8-SLC6A8C, containing intron 4 and exons 5-13, was identified. Herein, we report the identification of a novel variant SLC6A8D, and functional relevance of these isoforms.
Methods: Via (quantitative) RT-PCR, uptake assays, and confocal microscopy, we investigated their expression and function vis-a-vis creatine transport.
Results: SLC6A8D is homologous to SLC6A8C except for a deletion of exon 9 (without occurrence of a frame shift). Both contain an open reading frame encoding a truncated protein but otherwise identical to CTR1. Like SLC6A8, both variants are predominantly expressed in tissues with high energy requirement. Our experiments reveal that these truncated isoforms do not transport creatine. However, in SLC6A8 (CTR1)-overexpressing cells, a subsequent infection (transduction) with viral constructs encoding either the SLC6A8C (CTR4) or SLC6A8D (CfR5) isoform resulted in a significant increase in creatine accumulation compared to C1'R1 cells re-infected with viral constructs containing the empty vector. Moreover, transient transfection of CTR4 or C1'R5 into HEK293 cells resulted in significantly higher creatine uptake.
Conclusions: CTR4 and CTR5 are possible regulators of the creatine transporter since their overexpression results in upregulated CTR1 protein and creatine uptake.
General significance: Provides added insight into the mechanism(s) of creatine transport regulation. (c) 2014 Elsevier B.V. All rights reserved.
C1 [Ndika, Joseph D. T.; Martinez-Munoz, Cristina; Anand, Nandaja; van Dooren, Silvy J. M.; Kanhai, Warsha; Smith, Desiree E. C.; Jakobs, Cornelis; Salomons, Gajja S.] Vrije Univ Amsterdam, Med Ctr, Metab Unit, Dept Clin Chem, Amsterdam, Netherlands.
[Ndika, Joseph D. T.; Salomons, Gajja S.] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands.
[Salomons, Gajja S.] Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, Amsterdam, Netherlands.
RP Salomons, GS (reprint author), Metabool Lab, PK 1X 009,Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
EM g.salomons@vumc.nl
CR Arroyo JP, 2011, J AM SOC NEPHROL, V22, P1707, DOI 10.1681/ASN.2011020132
Bhalla V, 2005, MOL ENDOCRINOL, V19, P3073, DOI 10.1210/me.2005-0193
Black DL, 2000, CELL, V103, P367, DOI 10.1016/S0092-8674(00)00128-8
Boehm E, 2003, AM J PHYSIOL-ENDOC M, V284, pE399, DOI 10.1152/ajprendo.00259.2002
Boehmer C, 2006, J NEUROCHEM, V97, P911, DOI 10.1111/j.1471-4159.2006.03629.x
Boehmer C, 2003, J NEUROCHEM, V86, P1181, DOI 10.1046/j.1471-4159.2003.01937.x
Braissant O, 2011, AMINO ACIDS, V40, P1315, DOI 10.1007/s00726-011-0852-z
Brault JJ, 2003, J APPL PHYSIOL, V94, P2173, DOI 10.1152/japplphysiol.01171.2002
Darrabie MD, 2011, AM J PHYSIOL-ENDOC M, V300, pE870, DOI 10.1152/ajpendo.00554.2010
Dieter M, 2004, OBES RES, V12, P862, DOI 10.1038/oby.2004.104
di San Filippo CA, 2004, J BIOL CHEM, V279, P7247, DOI 10.1074/jbc.M309171200
Eichler EE, 1996, HUM MOL GENET, V5, P899, DOI 10.1093/hmg/5.7.899
Evangeliou A, 2009, CURR PHARM BIOTECHNO, V10, P683
Friedrich B, 2003, PFLUG ARCH EUR J PHY, V445, P693, DOI 10.1007/s00424-002-0993-8
Gecz J, 2009, TRENDS GENET, V25, P308, DOI 10.1016/j.tig.2009.05.002
Item CB, 2001, AM J HUM GENET, V69, P1127, DOI 10.1086/323765
Iyer GS, 1996, GENOMICS, V34, P143, DOI 10.1006/geno.1996.0254
Kitayama S, 1999, J BIOL CHEM, V274, P10731, DOI 10.1074/jbc.274.16.10731
Klein Autumn M., 2007, V46, P205
Kristensen AS, 2011, PHARMACOL REV, V63, P585, DOI 10.1124/pr.108.000869
LOIKE JD, 1988, P NATL ACAD SCI USA, V85, P807, DOI 10.1073/pnas.85.3.807
Lopez AJ, 1998, ANNU REV GENET, V32, P279, DOI 10.1146/annurev.genet.32.1.279
Martinez-Munoz C, 2008, GENE, V418, P53, DOI 10.1016/j.gene.2008.04.003
Modrek B, 2002, NAT GENET, V30, P13, DOI 10.1038/ng0102-13
MOLLER A, 1989, J NEUROCHEM, V52, P544, DOI 10.1111/j.1471-4159.1989.tb09154.x
Muller P.Y., 2002, BIOTECHNIQUES, V32, P1
Rosenberg EH, 2007, HUM MUTAT, V28, P890, DOI 10.1002/humu.20532
Salomons GS, 2001, AM J HUM GENET, V68, P1497, DOI 10.1086/320595
Shojaiefard M, 2005, BIOCHEM BIOPH RES CO, V334, P742, DOI 10.1016/j.bbrc.2005.06.164
Simon P, 2003, BIOINFORMATICS, V19, P1439, DOI 10.1093/bioinformatics/btg157
Sitte HH, 2004, MOL INTERV, V4, P38, DOI 10.1124/mi.4.1.38
Sitte HH, 2003, EUR J PHARMACOL, V479, P229, DOI 10.1016/j.ejphar.2003.08.072
Snyder PM, 2004, J BIOL CHEM, V279, P45753, DOI 10.1074/jbc.M407858200
Snyder PM, 2002, J BIOL CHEM, V277, P5, DOI 10.1074/jbc.C100623200
Sorkina T, 2006, J NEUROSCI, V26, P8195, DOI 10.1523/JNEUROSCI.1301-06.2006
Stockler S, 1996, AM J HUM GENET, V58, P914
Stockler-ipsiroglu S., 2006, MOL CELL BIOCHEM, V244, P211
Straumann N, 2006, BIOCHEM J, V393, P459, DOI 10.1042/BJ20050857
Tarnopolsky M, 2003, MOL CELL BIOCHEM, V244, P159, DOI 10.1023/A:1022447604792
Torres GE, 2007, CURR OPIN NEUROBIOL, V17, P304, DOI 10.1016/j.conb.2007.05.002
Vallejo-Illarramendi A, 2005, J NEUROCHEM, V95, P341, DOI 10.1111/j.1471-4159.2005.03370.x
Wallis J, 2005, CIRCULATION, V112, P3131, DOI 10.1161/CIRCULATIONAHA.105.572990
Wang ET, 2008, NATURE, V456, P470, DOI 10.1038/nature07509
Wyss M, 2000, PHYSIOL REV, V80, P1107
Yamashita A, 2005, NATURE, V437, P215, DOI 10.1038/nature03978
NR 45
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD JUN
PY 2014
VL 1840
IS 6
BP 2070
EP 2079
DI 10.1016/j.bbagen.2014.02.012
PG 10
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AH3GW
UT WOS:000336012700048
PM 24561156
ER
PT J
AU Schwarzkopf, S
Schilbach, L
Vogeley, K
Timmermans, B
AF Schwarzkopf, Sarah
Schilbach, Leonhard
Vogeley, Kai
Timmermans, Bert
TI "Making it explicit" makes a difference: Evidence for a dissociation of
spontaneous and intentional level 1 perspective taking in
high-functioning autism
SO COGNITION
LA English
DT Article
DE Visuospatial level 1 perspective taking; High-functioning autism;
Asperger syndrome; Attention shift; Implicit processing
ID ASPERGER-SYNDROME; SPECTRUM DISORDER; VISUAL-PERCEPTION; FALSE BELIEF;
ATTENTION; ADULTS; CHILDREN; OTHERS; SELF; REPRESENTATION
AB The ability of perspective taking is a fundamental aspect of social cognition. The ability to decide, what another person can or cannot see is referred to as "level 1 perspective taking." This is thought to be a process that we can make use of intentionally, but which also takes place spontaneously. Autism is characterized by impairments of social interaction, which are thought to be related to deficits in implicit rather than explicit perspective taking. In order to assess both levels of processing with regard to perspective taking, we employed an established task in patients and controls. Our results demonstrate that both groups engage in spontaneous level 1 perspective taking. In contrast to controls, however, patients reacted more slowly if they had to verify the other's as compared to their own perspective, which shows that participants with high-functioning autism have selective difficulties in explicit, but not implicit, level 1 perspective taking. These findings demonstrate that while spontaneous level 1 perspective taking appears to be intact in autism, this ability is impaired in patients when used explicitly. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Schwarzkopf, Sarah; Schilbach, Leonhard; Vogeley, Kai] Univ Hosp Cologne, Dept Psychiat, Cologne, Germany.
[Schwarzkopf, Sarah] Univ Freiburg, Ctr Cognit Sci, D-79098 Freiburg, Germany.
[Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med Cognit Neurosci INM3, Julich, Germany.
[Timmermans, Bert] Univ Aberdeen, Sch Psychol, Aberdeen AB9 1FX, Scotland.
RP Schwarzkopf, S (reprint author), Univ Freiburg, Ctr Cognit Sci, Friedrichstr 50, D-79098 Freiburg, Germany.
EM s.schwarzkopf@gmail.com
CR Allen G., 2001, FRONTIERS BIOSCIENCE, V6, P105
BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Beck A. T., 1987, BECK DEPRESSION INVE
Belopolsky AV, 2008, ACTA PSYCHOL, V128, P56, DOI 10.1016/j.actpsy.2007.09.012
Apperly IA, 2009, PSYCHOL REV, V116, P953, DOI 10.1037/a0016923
COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
David N, 2008, SOC COGN AFFECT NEUR, V3, P279, DOI 10.1093/scan/nsn023
David N, 2010, J AUTISM DEV DISORD, V40, P290, DOI 10.1007/s10803-009-0867-4
FLAVELL JH, 1981, DEV PSYCHOL, V17, P99, DOI 10.1037/0012-1649.17.1.99
Forster KI, 2003, BEHAV RES METH INS C, V35, P116, DOI 10.3758/BF03195503
Frischen A, 2009, COGNITION, V111, P212, DOI 10.1016/j.cognition.2009.02.003
Frith CD, 2006, NEURON, V50, P531, DOI 10.1016/j.neuron.2006.05.001
Frith CD, 2008, NEURON, V60, P503, DOI 10.1016/j.neuron.2008.10.032
Frith U, 2005, CONSCIOUS COGN, V14, P719, DOI 10.1016/j.concog.2005.04.006
Frith U, 1996, J PSYCHOPHARMACOL, V10, P48, DOI 10.1177/026988119601000108
Greenaway R, 2005, PSYCHOL SCI, V16, P987, DOI 10.1111/j.1467-9280.2005.01648.x
Hamilton AFD, 2009, COGNITION, V113, P37, DOI 10.1016/j.cognition.2009.07.007
Hare B, 2001, ANIM BEHAV, V61, P139, DOI 10.1006/anbe.2000.1518
Hautzinger M, 1995, BECK DEPRESSIONS INV, V2
HOBSON RP, 1984, J AUTISM DEV DISORD, V14, P85, DOI 10.1007/BF02408558
Kockler H, 2010, CONSCIOUS COGN, V19, P690, DOI 10.1016/j.concog.2010.03.003
Kovacs AM, 2010, SCIENCE, V330, P1830, DOI 10.1126/science.1190792
Leekam S, 1997, BRIT J DEV PSYCHOL, V15, P77
LESLIE AM, 1988, BRIT J DEV PSYCHOL, V6, P315
Lombardo M. V., 2009, J COGNITIVE NEUROSCI, V22, P1623, DOI DOI 10.1162/J0CN.2009.21287
Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
Lombardo MV, 2011, CONSCIOUS COGN, V20, P130, DOI 10.1016/j.concog.2010.09.006
Loth E, 2008, AUTISM RES, V1, P179, DOI 10.1002/aur.19
Loth E, 2010, NEUROPSYCHOLOGIA, V48, P1227, DOI 10.1016/j.neuropsychologia.2009.12.023
Michelon P, 2006, PERCEPT PSYCHOPHYS, V68, P327, DOI 10.3758/BF03193680
Mitchell JP, 2006, NEURON, V50, P655, DOI 10.1016/j.neuron.2006.03.040
NEWCOMBE N, 1989, ADV CHILD DEV BEHAV, V22, P203
Pearson A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00652
Piaget J., 1956, CHILDS CONCEPTION SP
Qureshi AW, 2010, COGNITION, V117, P230, DOI 10.1016/j.cognition.2010.08.003
REED T, 1990, J AUTISM DEV DISORD, V20, P555, DOI 10.1007/BF02216060
Ruffman T, 2001, J EXP CHILD PSYCHOL, V80, P201, DOI 10.1006/jecp.2001.2633
Samson D, 2010, J EXP PSYCHOL HUMAN, V36, P1255, DOI 10.1037/a0018729
Schilbach L, 2012, AUTISM, V16, P151, DOI 10.1177/1362361311409258
Schilbach L, 2013, BEHAV BRAIN SCI, V36, P393, DOI 10.1017/S0140525X12000660
Sebanz N, 2005, COGN NEUROPSYCHOL, V22, P433, DOI 10.1080/02643290442000121
Senju A, 2010, DEV PSYCHOPATHOL, V22, P353, DOI 10.1017/S0954579410000106
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
Surtees ADR, 2012, BRIT J DEV PSYCHOL, V30, P75, DOI 10.1111/j.2044-835X.2011.02063.x
Townsend J, 2010, HANDBOOK OF MEDICAL NEUROPSYCHOLOGY: APPLICATIONS OF COGNITIVE NEUROSCIENCE, P165, DOI 10.1007/978-1-4419-1364-7_10
Tversky B, 2009, COGNITION, V110, P124, DOI 10.1016/j.cognition.2008.10.008
Vogeley K, 2004, J COGNITIVE NEUROSCI, V16, P817, DOI 10.1162/089892904970799
Zwickel J, 2011, SOC COGN AFFECT NEUR, V6, P564, DOI 10.1093/scan/nsq088
Zwickel J, 2009, PSYCHON B REV, V16, P1089, DOI 10.3758/PBR.16.6.1089
NR 53
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
EI 1873-7838
J9 COGNITION
JI Cognition
PD JUN
PY 2014
VL 131
IS 3
BP 345
EP 354
DI 10.1016/j.cognition.2014.02.003
PG 10
WC Psychology, Experimental
SC Psychology
GA AH3FG
UT WOS:000336008500003
PM 24632324
ER
PT J
AU Bouvet, L
Simard-Meilleur, AA
Paignon, A
Mottron, L
Donnadieu, S
AF Bouvet, Lucie
Simard-Meilleur, Andree-Anne
Paignon, Adeline
Mottron, Laurent
Donnadieu, Sophie
TI Auditory local bias and reduced global interference in autism
SO COGNITION
LA English
DT Article
DE Global; Local; Autism; Auditory processing; Local bias; Perception
ID SPECTRUM DISORDERS; COGNITIVE-STYLE; PERCEPTION; PRECEDENCE;
ADOLESCENTS; INFORMATION; MORPHOMETRY; ABILITIES; COHERENCE; ATTENTION
AB Processing local elements of hierarchical patterns at a superior level and independently from an intact global influence is a well-established characteristic of autistic visual perception. However, whether this confirmed finding has an equivalent in the auditory modality is still unknown. To fill this gap, 18 autistics and 18 typical participants completed a melodic decision task where global and local level information can be congruent or incongruent. While focusing either on the global (melody) or local level (group of notes) of hierarchical auditory stimuli, participants have to decide whether the focused level is rising or falling. Autistics showed intact global processing, a superior performance when processing local elements and a reduced global-to-local interference compared to typical participants. These results are the first to demonstrate that autistic processing of auditory hierarchical stimuli closely parallels processing of visual hierarchical stimuli. When analyzing complex auditory information, autistic participants present a local bias and a more autonomous local processing, but not to the detriment of global processing. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Bouvet, Lucie; Paignon, Adeline; Donnadieu, Sophie] CNRS, Lab Psychol & Neurocognit, UMR 5105, Grenoble, France.
[Bouvet, Lucie] Univ Lille 3, Lab Neurosci Fonct & Pathol, UFR Psychol, Villeneuve Dascq, France.
[Simard-Meilleur, Andree-Anne; Mottron, Laurent] Hop Riviere des Prairies, CETEDUM, Montreal, PQ, Canada.
[Simard-Meilleur, Andree-Anne; Mottron, Laurent] Dept Psychiat, Montreal, PQ, Canada.
[Paignon, Adeline; Donnadieu, Sophie] Univ Savoie, Chambery, France.
RP Bouvet, L (reprint author), Univ Lille Nord France, Lab Neurosci Fonct & Pathol, Lille, France.
EM lucie.bouvet@gmail.com
CR Austen EL, 2003, J VISION, V3, P64, DOI 10.1167/3.1.7
Bouvet L, 2011, ACTA PSYCHOL, V138, P329, DOI 10.1016/j.actpsy.2011.08.004
Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
Charbonneau G, 2013, NEUROPSYCHOLOGIA, V51, P1002, DOI 10.1016/j.neuropsychologia.2013.02.009
Collignon O, 2010, NEUROPSYCHOLOGIA, V48, P220, DOI 10.1016/j.neuropsychologia.2009.09.007
Fiebelkorn IC, 2013, CORTEX, V49, P1259, DOI 10.1016/j.cortex.2012.04.007
Foxton JM, 2003, BRAIN, V126, P2703, DOI 10.1093/brain/awg274
Frith U., 1989, AUTISM EXPLAINING EN
Glaser E, 2012, INT J PSYCHOPHYSIOL, V85, P17, DOI 10.1016/j.ijpsycho.2012.01.007
Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Hardan AY, 2009, PSYCHIAT RES-NEUROIM, V174, P57, DOI 10.1016/j.pscychresns.2009.03.005
Heaton P, 2007, J AUTISM DEV DISORD, V37, P1355, DOI 10.1007/s10803-006-0283-y
Heaton P, 1999, NEUROCASE, V5, P503, DOI 10.1080/13554799908402745
Heaton P, 2005, J AUTISM DEV DISORD, V35, P787, DOI 10.1007/s10803-005-0024-7
Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
Jarrold C, 2005, DEVELOPMENTAL SCI, V8, P344, DOI 10.1111/j.1467-7687.2005.00422.x
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Justus T, 2005, COGNITION, V98, P31, DOI 10.1016/j.cognition.2004.11.001
Keown CL, 2013, CELL REP, V5, P567, DOI 10.1016/j.celrep.2013.10.003
List A., 2007, BRAIN RES, V1153, P322
Liu YN, 2011, NEUROPSYCHOLOGIA, V49, P2105, DOI 10.1016/j.neuropsychologia.2011.04.005
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2000, AUTISM DIAGNOSTIC OB, V30
Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mottron L, 2013, NEUROSCI BIOBEHAV R, V37, P209, DOI 10.1016/j.neubiorev.2012.11.016
Mottron L., 2013, ENCY AUTISM SPECTRUM, P2168
Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253
NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
O'Connor K, 2012, NEUROSCI BIOBEHAV R, V36, P836, DOI 10.1016/j.neubiorev.2011.11.008
OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x
Pellicano E, 2011, AUTISM RES, V4, P271, DOI 10.1002/aur.201
PERETZ I, 1990, BRAIN, V113, P1185, DOI 10.1093/brain/113.4.1185
Poirel N, 2008, ACTA PSYCHOL, V127, P1, DOI 10.1016/j.actpsy.2006.12.001
Poirier M, 2011, J ABNORM PSYCHOL, V120, P247, DOI 10.1037/a0022298
Quintin EM, 2013, CHILD NEUROPSYCHOL, V19, P250, DOI 10.1080/09297049.2011.653540
Romei V, 2011, CURR BIOL, V21, P334, DOI 10.1016/j.cub.2011.01.035
Samson F, 2011, NEUROPSYCHOLOGIA, V49, P546, DOI 10.1016/j.neuropsychologia.2010.12.033
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Sinclair J., 1999, WHY I DISLIKE PERSON
Supekar K, 2013, CELL REP, V5, P738, DOI 10.1016/j.celrep.2013.10.001
Townsend J. T., 1983, STOCHASTIC MODELLING
Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096
White SJ, 2011, J AUTISM DEV DISORD, V41, P1565, DOI 10.1007/s10803-011-1182-4
NR 45
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
EI 1873-7838
J9 COGNITION
JI Cognition
PD JUN
PY 2014
VL 131
IS 3
BP 367
EP 372
DI 10.1016/j.cognition.2014.02.006
PG 6
WC Psychology, Experimental
SC Psychology
GA AH3FG
UT WOS:000336008500005
PM 24637103
ER
PT J
AU Cote, DL
Jones, VL
Barnett, C
Pavelek, K
Nguyen, H
Sparks, SL
AF Cote, Debra L.
Jones, Vita L.
Barnett, Crystal
Pavelek, Karin
Nguyen, Hoang
Sparks, Shannon L.
TI Teaching Problem Solving Skills to Elementary Age Students with Autism
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID SELF-DETERMINATION; DEVELOPMENTAL-DISABILITIES; GENERAL CURRICULUM;
LEARNING-MODEL; MODERATE; INSTRUCTION
AB Students with disabilities need problem-solving skills to promote their success in solving the problems of daily life. The research into problem-solving instruction has been limited for students with autism. Using a problem-solving intervention and the Self Determined Learning Model of Instruction, three elementary age students with autism were taught to set personal goals related to their academic achievement, identify problems, and self-evaluate their problems-solving skills. A multiple-probe design was used, and data suggested that all students achieved and maintained their self-set goals.
C1 [Cote, Debra L.; Jones, Vita L.; Barnett, Crystal; Pavelek, Karin; Nguyen, Hoang] Calif State Univ Fullerton, Fullerton, CA 92834 USA.
[Sparks, Shannon L.] Univ Nevada, Las Vegas, NV 89154 USA.
RP Cote, DL (reprint author), Calif State Univ Fullerton, Dept Special Educ, Coll Pk 570,POB 6868, Fullerton, CA 92834 USA.
EM dcote@fullerton.edu
CR Agran M, 2006, RES PRACT PERS SEV D, V31, P230
Agran M, 2002, REM SPEC EDUC, V23, P279, DOI 10.1177/07419325020230050301
Agran M., 2005, MENTAL RETARDATION I, P255
Agran M, 2001, RES DEV DISABIL, V22, P319, DOI 10.1016/S0891-4222(01)00075-0
Alderson-Day B., 2010, J AUTISM DEV DISORD, V41, P555
Bicard S. C., 2010, MEASURING BEHAV
Cole B., 1986, PRINCESS SMARTYPANTS
Cote D, 2010, EDUC TRAIN AUTISM DE, V45, P512
Cote D. L., 2009, THESIS U NEVADA LAS
Cote DL, 2011, INTERV SCH CLIN, V46, P259, DOI 10.1177/1053451210395387
Friend M., 2011, SPECIAL ED CONTEMPOR
Glago K, 2009, REM SPEC EDUC, V30, P372, DOI 10.1177/0741932508324394
Glago K. D., 2005, DISS ABSTR INT, V66, P549
Homer R. H., 2005, EXCEPT CHILDREN, V71, P165
HORNER RD, 1978, J APPL BEHAV ANAL, V11, P189, DOI 10.1901/jaba.1978.11-189
Hughes S., 1984, EVENING ALFIES
Mims PJ, 2012, FOCUS AUTISM DEV DIS, V27, P67, DOI 10.1177/1088357612446859
Palmer S. B., 2002, TEACHERS GUIDE IMPLE
Palmer S. B., 2002, PARENTS GUIDE SELF D
Palmer SB, 2003, REM SPEC EDUC, V24, P115, DOI 10.1177/07419325030240020601
Palmer SB, 2004, EXCEPT CHILDREN, V70, P427
Ryndak DL, 2010, EDUC TRAIN AUTISM DE, V45, P323
Tawney J. W., 1984, SINGLE SUBJECT RES S
Wehmeyer ML, 2000, EXCEPT CHILDREN, V66, P439
Wehmeyer ML, 2010, EDUC TRAIN AUTISM DE, V45, P475
NR 25
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2014
VL 49
IS 2
BP 189
EP 199
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3IA
UT WOS:000336015700002
ER
PT J
AU Ergenekon, Y
Tekin-Iftar, E
Kapan, A
Akmanoglu, N
AF Ergenekon, Yasemin
Tekin-Iftar, Elif
Kapan, Alper
Akmanoglu, Nurgul
TI Comparison of Video and Live Modeling in Teaching Response Chains to
Children with Autism
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID PERSPECTIVE-TAKING; IN-VIVO; PLAY; PRESCHOOLERS; REINFORCEMENT;
INTERVENTIONS; INDIVIDUALS; SEQUENCES; PROMPTS; PICTURE
AB Research has shown that video and live modeling are both effective in teaching new skills to children with autism. An adapted alternating treatments design was used to compare the effectiveness and efficiency of video and live modeling in. teaching response chains to three children with autism. Each child was taught two chained skills; one skill was planned to be taught by video modeling and the other was planned to be taught by live modeling. Results showed that two children were able to acquire the response chains assigned to them successfully with both procedures. For the third child, live modeling was found to be more effective than video modeling. When the efficiency of two procedures is considered, no dramatic differences were observed in favor of either modeling across participants.
C1 [Ergenekon, Yasemin; Tekin-Iftar, Elif; Kapan, Alper; Akmanoglu, Nurgul] Anadolu Univ, TR-26470 Eskisehir, Turkey.
RP Ergenekon, Y (reprint author), Anadolu Univ, Engelliler Arastirma Enstitusu, TR-26470 Eskisehir, Turkey.
EM yergenek@anadolu.edu.tr
CR Akmanoglu N., 2011, AUTISM INT J RES PRA, V15, P1
Alberto PA, 2005, RES DEV DISABIL, V26, P327, DOI 10.1016/j.ridd.2004.11.002
Apple AL, 2005, J POSIT BEHAV INTERV, V7, P33, DOI 10.1177/10983007050070010401
Bandura A., 1977, SOCIAL LEARNING THEO
Bellini S, 2007, EXCEPT CHILDREN, V73, P264
Bidwell MA, 2004, BEHAV INTERVENT, V19, P263, DOI 10.1002/bin.165
BILLINGSLEY F, 1980, BEHAV ASSESS, V2, P229
CHARLOP MH, 1983, J ABNORM CHILD PSYCH, V11, P355, DOI 10.1007/BF00914244
Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
Corbett B., 2003, BEHAV ANAL TODAY, V4, P367
Corbett BA, 2005, J EARLY INTENSIVE BE, V2, P1
D'Ateno P, 2003, J POSIT BEHAV INTERV, V5, P5, DOI 10.1177/10983007030050010801
Delano ME, 2007, REM SPEC EDUC, V28, P33, DOI 10.1177/07419325070280010401
Dettmer S., 2000, FOCUS AUTISM OTHER D, V15, P163, DOI DOI 10.1177/108835760001500307
EGEL AL, 1981, J APPL BEHAV ANAL, V14, P3, DOI 10.1901/jaba.1981.14-3
Gena A, 2005, J AUTISM DEV DISORD, V35, P545, DOI 10.1007/s10803-005-0014-9
GOLDSTEIN H, 1992, J APPL BEHAV ANAL, V25, P265, DOI 10.1901/jaba.1992.25-265
Hine JF, 2006, TOP EARLY CHILD SPEC, V26, P83, DOI 10.1177/02711214060260020301
Holcombe A., 1994, TOP EARLY CHILD SPEC, V16, P168
Jahr E, 2000, RES DEV DISABIL, V21, P151, DOI 10.1016/S0891-4222(00)00031-7
Keen D, 2007, J DEV PHYS DISABIL, V19, P291, DOI 10.1007/s10882-007-9044-x
Kinney EM, 2003, J POSIT BEHAV INTERV, V5, P22, DOI 10.1177/10983007030050010301
Kuder S. J., 2010, M COUNC EXC CHILDR N
LeBlanc LA, 2003, J APPL BEHAV ANAL, V36, P253, DOI 10.1901/jaba.2003.36-253
MacDonald R, 2009, J APPL BEHAV ANAL, V42, P43, DOI 10.1901/jaba.2009.42-43
Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x
Norman J. M., 2001, Journal of Special Education Technology, V16
Paterson CR, 2007, BEHAV MODIF, V31, P660, DOI 10.1177/0145445507301651
Rao S., 2006, TEACHING EXCEPTIONAL, V38, P26
Reagon K. A., 2006, EDUC TREAT CHILD, V29, P517
Shipley-Benamou R., 2002, J POSIT BEHAV INTERV, V4, P163
Sigafoos J., 2005, J BEHAV ED, V14, P189, DOI DOI 10.1007/S10864-00506297-2
Tawney J. W., 1984, SINGLE SUBJECT RES S
Van Laarhoven T, 2010, FOCUS AUTISM DEV DIS, V25, P195, DOI 10.1177/1088357610380412
Webber J., 2002, ED STUDENTS AUTISM Q
NR 36
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2014
VL 49
IS 2
BP 200
EP 213
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3IA
UT WOS:000336015700003
ER
PT J
AU Reilly, C
Hughes, C
Harvey, M
Brigham, N
Cosgriff, J
Kaplan, L
Bernstein, R
AF Reilly, Caitlin
Hughes, Carolyn
Harvey, Michelle
Brigham, Nicolette
Cosgriff, Joseph
Kaplan, Lauren
Bernstein, Rebekah
TI "Let's Talk!": Increasing Novel Peer-Directed Questions by High School
Students with Autism to Their General Education Peers
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID HIGH-FUNCTIONING CHILDREN; SOCIAL-SKILLS; SPECTRUM DISORDERS;
INTELLECTUAL DISABILITIES; ASPERGER SYNDROME; ADOLESCENTS; INTERVENTION;
RECIPROCITY; VALIDITY; BEHAVIOR
AB We taught three high school students with high-functioning autism to increase their novel peer-directed questions when using a communication book to converse with general education partners at school. Novel question training was associated with participants asking peer-directed questions not displayed in communication books across a variety of conversational partners. Partners systematically responded to questions participants asked throughout the study, whether questions asked were displayed in participants' books or not. In addition, partners' initiations to participants increased when participants asked more peer-directed questions not displayed in their books. Social validation data gathered from participants and partners generally confirmed the importance of the study's goals and outcomes; normative data indicated that participants engaged in conversation in a fashion similar to their general education peers. Findings are discussed with respect to future research and practice.
C1 [Reilly, Caitlin; Harvey, Michelle; Brigham, Nicolette; Cosgriff, Joseph; Kaplan, Lauren; Bernstein, Rebekah] Vanderbilt Univ, Nashville, TN USA.
[Hughes, Carolyn] CUNY Queens Coll, Flushing, NY 11367 USA.
RP Hughes, C (reprint author), CUNY Queens Coll, Educ Program, 65-30 Kissena Blvd,Powdermaker Hall 033, Flushing, NY 11367 USA.
EM Carolyn.hughes@qc.cuny.edu
CR Baer D. M., 1970, CONTROL HUMAN BEHAV
Bellini S, 2008, CHILD ADOL PSYCH CL, V17, P857, DOI 10.1016/j.chc.2008.06.008
Carter EW, 2005, AM J MENT RETARD, V110, P366, DOI 10.1352/0895-8017(2005)110[366:FISIAH]2.0.CO;2
Chen FS, 2010, J EXP SOC PSYCHOL, V46, P850, DOI 10.1016/j.jesp.2010.04.012
CHRISTOPHER JS, 1991, BEHAV MODIF, V15, P22, DOI 10.1177/01454455910151002
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
Davis KM, 2010, FOCUS AUTISM DEV DIS, V25, P12, DOI 10.1177/1088357609354299
DiSalvo C., 2002, FOCUS AUTISM OTHER D, V17, P198, DOI DOI 10.1177/10883576020170040201
Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0
Fey M., 1986, LANGUAGE INTERVENTIO
Gast D. L., 2010, SINGLE SUBJECT RES M, P276
GAYLORDROSS RJ, 1984, J APPL BEHAV ANAL, V17, P229, DOI 10.1901/jaba.1984.17-229
HARING TG, 1992, J APPL BEHAV ANAL, V25, P319, DOI 10.1901/jaba.1992.25-319
Hughes C, 2013, FOCUS AUTISM DEV DIS, V28, P241, DOI 10.1177/1088357613487019
Hughes C, 2011, RES PRACT PERS SEV D, V36, P46
Hughes C, 2000, J ASSOC PERS SEVERE, V25, P153, DOI 10.2511/rpsd.25.3.153
Hughes C, 1999, AM J MENT RETARD, V104, P533, DOI 10.1352/0895-8017(1999)104<0533:SIOHSS>2.0.CO;2
HUNT P, 1990, J ASSOC PERS SEVERE, V15, P250
Kazdin A. E., 1982, SINGLE CASE RES DESI
Koegel R. L., 2006, PIVOTAL RESPONSE TRE
Laugeson EA, 2012, J AUTISM DEV DISORD, V42, P1025, DOI 10.1007/s10803-011-1339-1
Laushey KM, 2000, J AUTISM DEV DISORD, V30, P183, DOI 10.1023/A:1005558101038
McDonald ME, 2003, RES DEV DISABIL, V24, P453, DOI 10.1016/j.ridd.2003.04.001
Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
Nadig A, 2010, NEUROPSYCHOLOGIA, V48, P2730, DOI 10.1016/j.neuropsychologia.2010.05.020
NIENTIMP EG, 1992, J SCHOOL PSYCHOL, V30, P343, DOI 10.1016/0022-4405(92)90002-M
Owen-DeSchryver JS, 2008, FOCUS AUTISM DEV DIS, V23, P15, DOI 10.1177/1088357608314370
Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
Schopler E., 2010, CHILDHOOD AUTISM RAT, VSecond
Shattuck PT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027176
Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
van Ommeren TB, 2012, J AUTISM DEV DISORD, V42, P1001, DOI 10.1007/s10803-011-1331-9
Weiss MJ, 2001, BEHAV MODIF, V25, P785, DOI 10.1177/0145445501255007
WOLF MM, 1978, J APPL BEHAV ANAL, V11, P203, DOI 10.1901/jaba.1978.11-203
NR 34
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2014
VL 49
IS 2
BP 214
EP 231
PG 18
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3IA
UT WOS:000336015700004
ER
PT J
AU Ardic, A
Cavkaytar, A
AF Ardic, Avsar
Cavkaytar, Atilla
TI Effectiveness of the Modified Intensive Toilet Training Method on
Teaching Toilet Skills to Children with Autism
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
AB The purpose of this study was to determine effectiveness of a modified version of Azrin and Foxx's (1971) intensive toilet training method on teaching of toilet skills to children with autism. This method consists of administering extra fluids and a time schedule, but does not use overcorrection procedures. Implementation requires a study of six hours per day. The study was conducted with three children with autism in an educational setting and used a multiple probe design. Both inter-observer and procedural reliability data were collected. Graphical analysis was used to determine effectiveness of a modified version of Azrin and Foxx's method for teaching toilet skills to children with autism. Results of the study indicate that the modified Azrin and Foxx method was effective in teaching dryness and urinating into the toilet at acquisition level to children with autism. Parents of the research subjects were very satisfied with the results.
C1 [Ardic, Avsar] Ege Univ, TR-35040 Izmir, Turkey.
[Cavkaytar, Atilla] Anadolu Univ, Eskisehir, Turkey.
RP Ardic, A (reprint author), Ege Univ, Fac Educ, Dept Special Educ, TR-35040 Izmir, Turkey.
EM avsar.ardic@ege.edu.tr
CR (APA) APA, 2000, DIAGN STAT MAN MENT
Averink M, 2005, RES DEV DISABIL, V26, P143, DOI 10.1016/j.ridd.2004.02.001
AZRIN NH, 1971, J APPL BEHAV ANAL, V4, P89, DOI 10.1901/jaba.1971.4-89
Bettison S., 1982, TOILET TRAINING INDE
Chung KM, 2007, J DEV PHYS DISABIL, V19, P449, DOI 10.1007/s10882-007-9062-8
Cicero FR, 2002, RES DEV DISABIL, V23, P319, DOI 10.1016/S0891-4222(02)00136-1
Detweiler D. D., 2005, FOCUS AUTISM OTHER D, V20, P98, DOI DOI 10.1177/10883576050200020601
ELLIS NR, 1963, AM J MENT DEF, V68, P98
Keen D, 2007, J DEV PHYS DISABIL, V19, P291, DOI 10.1007/s10882-007-9044-x
Luiselli E., 1996, FOCUS AUTISM OTHER D, V11, P158
McManus M., 2003, INT J SPECIAL ED, V18, P73
Myles B. S., 1999, FOCUS AUTISM OTHER D, V14, P106, DOI 10.1177/108835769901400206
Oorsouw W. M. W. J., 2009, RES DEV DISABIL, V30, P1388
Post AR, 2004, BEHAV INTERVENT, V19, P45, DOI 10.1002/bin.149
Ricciardi JN, 2003, CHILD FAM BEHAV THER, V25, P53, DOI 10.1300/J019v25n04_04
Richards S. B., 1998, SINGLE SUBJECT RES A
Snell M. E., 1993, SELF CARE SKILLS INS
Tarbox RSE, 2004, J APPL BEHAV ANAL, V37, P97, DOI 10.1901/jaba.2004.37-97
Tekin-Iftar E., 2006, OZEL EGITIMDE YANLIS, V2nd
Turnbull A, 2007, EXCEPTIONAL LIVES SP
Williams G, 2003, J DEV PHYS DISABIL, V15, P335, DOI 10.1023/A:1026310216069
NR 21
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2014
VL 49
IS 2
BP 263
EP 276
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3IA
UT WOS:000336015700007
ER
PT J
AU West, EA
Pirtle, JM
AF West, Elizabeth A.
Pirtle, Jody M.
TI Mothers' and Fathers' Perspectives on Quality Special Educators and the
Attributes that Influence Effective Inclusive Practices
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID SEVERE DISABILITIES; PARENTS PERCEPTIONS; CHILDREN; SATISFACTION;
MODERATE; STIGMA; AUTISM; VIEWS
AB Research over the last decade or so has made it clear that quality teachers matter to student achievement. What is less clear is the ways in which they matter and how we can prepare such high-quality teachers for a variety of contexts. The research question guiding this project was what do important stakeholder groups perceive to be the skills and knowledge that high quality, beginning special educators need when they start teaching? In the field of special education, there is no clear consensus on this matter; voices of key players-parents of children with moderate to severe disabilities-have not been adequately heard. This study fills this gap in our understanding as focus group interviews were conducted with parents of children with moderate to severe disabilities. Analysis of these interviews revealed that participants' responses fell under five major themes: Understanding, Teacher Training, Effective Communication, System, and Teacher Disposition. Inclusive practices are highlighted as parents identified these across all themes. Teacher education developers can play a major role in transforming programs to better align with what parents perceive to be the skills and knowledge that a high quality beginning special educator needs when he/she starts teaching. This information can be used to revise and renew programs to better prepare special educators.
C1 [West, Elizabeth A.] Univ Washington, Seattle, WA 98195 USA.
[Pirtle, Jody M.] Univ Arizona, Tucson, AZ 85721 USA.
RP West, EA (reprint author), Univ Washington, Area Special Educ, Box 353600, Seattle, WA 98195 USA.
EM eawest@u.washington.edu
CR Altrichter H., 2008, TEACHERS INVESTIGATE
Atkinson P., 1993, ED RES CURRENT ISSUE
Bailey DB, 1999, EXCEPT CHILDREN, V65, P367
BROTHERSON MJ, 1994, TOP EARLY CHILD SPEC, V14, P101
Brownell MT, 2004, J SPEC EDUC, V38, P56, DOI 10.1177/00224669040380010501
Brownell MT, 2005, J SPEC EDUC, V38, P242, DOI 10.1177/00224669050380040601
Cohen L, 2000, RES METHODS ED
Danforth S., 2008, DISABILITY POLITICS
Davern L., 1999, TEACHER ED SPECIAL E, V22, P165
Freeman SFN, 1999, REM SPEC EDUC, V20, P143, DOI 10.1177/074193259902000304
Friend M., 2011, SPECIAL ED CONTEMPOR
Gallagher PA, 2000, EDUC TRAIN MENT RET, V35, P135
Garrick-Duhaney L. M., 2000, REM SPEC EDUC, V21, P121, DOI 10.1177/074193250002100209
GRAY DE, 1993, SOCIOL HEALTH ILL, V15, P102, DOI 10.1111/1467-9566.ep11343802
Hammersley M, 1995, ETHNOGRAPHY PRINCIPL
HANLINE MF, 1989, EXCEPT CHILDREN, V55, P487
Hutton A. M., 2005, FOCUS AUTISM OTHER D, V20, P180, DOI [10.1177/10883576050200030601, DOI 10.1177/10883576050200030601]
Hyson M., 2003, PREPARING EARLY CHIL
Interstate New Teacher Assessment and Support Consortium (INTASC), 2007, MOD STAND BEG TEACH
Jenkinson J. C., 1998, INT J DISABIL DEV ED, V45, P189, DOI DOI 10.1080/1034912980450205
Kohler F. W., 1999, FOCUS AUTISM OTHER D, V14, P150, DOI DOI 10.1177/108835769901400304
Krueger R. A, 1994, FOCUS GROUPS PRACTIC
Krueger Richard A., 2000, FOCUS GROUPS PRACTIC, V3rd
Lake JF, 2000, REM SPEC EDUC, V21, P240, DOI 10.1177/074193250002100407
Lea D, 2006, J EARLY INTERVENTION, V28, P264, DOI 10.1177/105381510602800403
Leyser Y., 2004, INT J DISABIL DEV ED, V51, P271, DOI [10.1080/1034912042000259233, DOI 10.1080/1034912042000259233]
McHatton PA, 2005, TOP EARLY CHILD SPEC, V25, P131, DOI 10.1177/02711214050250030101
Miles Matthew B., 1994, QUALITATIVE DATA ANA
Paisley P. O., 2001, HDB COUNSELING, P481
Palmer DS, 2001, EXCEPT CHILDREN, V67, P467
Palmer DS, 1998, EXCEPT CHILDREN, V64, P271
Rao SS, 2000, MENT RETARD, V38, P475, DOI 10.1352/0047-6765(2000)038<0475:POAAAM>2.0.CO;2
Renty J, 2006, CHILD CARE HLTH DEV, V32, P371, DOI 10.1111/j.1365-2214.2006.00584.x
Rouse M., 1996, CAMB J EDUC, V26, P71
RYNDAK DL, 1995, J ASSOC PERS SEVERE, V20, P147
Schall C, 2000, J CHILD FAM STUD, V9, P409, DOI DOI 10.1023/A:1009456825063
Seery ME, 2000, REM SPEC EDUC, V21, P268, DOI 10.1177/074193250002100504
SMITH B, 1994, J AUTISM DEV DISORD, V24, P551, DOI 10.1007/BF02172137
Stewart David W, 1990, FOCUS GROUPS THEORY
Turnbull R., 2002, EXCEPTIONAL LIVES SP
Turner-Vorbeck T., 2008, OTHER KINDS FAMILIES
Vazins J., 2009, BOSTON GLOBE
Yssel N, 2007, REM SPEC EDUC, V28, P356, DOI 10.1177/07419325070280060501
NR 43
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2014
VL 49
IS 2
BP 290
EP 300
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AH3IA
UT WOS:000336015700009
ER
PT J
AU Camacho, J
Jones, K
Miller, E
Ariza, J
Noctor, S
Van de Water, J
Martinez-Cerdeno, V
AF Camacho, Jasmin
Jones, Karen
Miller, Elaine
Ariza, Jeanelle
Noctor, Stephen
Van de Water, Judy
Martinez-Cerdeno, Veronica
TI Embryonic intraventricular exposure to autism-specific maternal
autoantibodies produces alterations in autistic-like stereotypical
behaviors in offspring mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism spectrum disorders; Maternal antibodies; In utero exposure;
Immune; Mouse behavior
ID ENVIRONMENTAL-FACTORS; ANTIBRAIN ANTIBODIES; IGG ANTIBODIES; BRAIN;
PREGNANCY; CHILDREN; MOTHERS; PROTEINS
AB Multiple studies have implicated a role of maternal autoantibodies reactive against fetal brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the current study, we examined the impact of brain-reactive maternal autoantibodies of mothers of children with autism (MAU) on offspring behavior in mice compared to offspring exposed to non-reactive IgG of mothers of typically developing children (MTD). Embryonic offspring were exposed to a single intraventricular injection of MAU or MTD IgG on embryonic day 14. Offspring were allowed to mature to adulthood and were subsequently tested for sociability and stereotypic behaviors using a 3-chambered social approach task, marble burying task, and assessment of spontaneous grooming behaviors in response to a novel environment. Results indicate that MAU offspring display autistic-like stereotypical behavior in both marble burying and spontaneous grooming behaviors. Additionally, small alterations in social approach behavior were also observed in MAU offspring compared to MTD offspring. This report demonstrates for the first time the effects of a single, low dose intraventricular exposure of IgG derived from individual MAU samples on offspring behavior. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Camacho, Jasmin; Miller, Elaine; Ariza, Jeanelle; Martinez-Cerdeno, Veronica] Univ Calif Davis, Dept Pathol & Lab Med, Sacramento, CA 95817 USA.
[Camacho, Jasmin; Miller, Elaine; Ariza, Jeanelle; Martinez-Cerdeno, Veronica] Inst Pediat Regenerat Med, Sacramento, CA 95817 USA.
[Camacho, Jasmin; Miller, Elaine; Ariza, Jeanelle; Martinez-Cerdeno, Veronica] Shriners Hosp Children Northern Calif, Sacramento, CA 95817 USA.
[Jones, Karen; Noctor, Stephen; Van de Water, Judy; Martinez-Cerdeno, Veronica] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
[Jones, Karen; Van de Water, Judy] Univ Calif Davis, Dept Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA.
[Noctor, Stephen] Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
RP Martinez-Cerdeno, V (reprint author), 2425 Stockton Blvd, Sacramento, CA 95817 USA.
EM vmartinezcerdeno@ucdavis.edu
FU NIMH [R01-MH094681]; NIEHS [1 P01 ES11269-01, 1 R01-ES015359]; U.S.
Environmental Protection Agency (U.S.EPA) through the Science to Achieve
Results (STAR) program [R829388]; Shriners Hospitals
FX Funding for this project was obtained from the NIMH (R01-MH094681),
NIEHS 1 P01 ES11269-01, the U.S. Environmental Protection Agency
(U.S.EPA) through the Science to Achieve Results (STAR) program (Grant
R829388), NIEHS 1 R01-ES015359, and Shriners Hospitals.
CR American Psychiatric Association (APA), 2013, DIAGN STAT MAN MENT, V5
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
Bauman MD, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.47
Braunschweig D, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.50
Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
Braunschweig D, 2011, J AUTISM DEV DISORD
Braunschweig D, 2012, J NEUROIMMUNOL, V252, P56, DOI 10.1016/j.jneuroim.2012.08.002
Braunschweig D, 2012, ARCH NEUROL-CHICAGO, V69, P693, DOI 10.1001/archneurol.2011.2506
Brimberg L, 2013, MOL PSYCHIATR, V18, P1171, DOI 10.1038/mp.2013.101
Chaouat G, 2007, SEMIN IMMUNOPATHOL, V29, P95, DOI 10.1007/s00281-007-0069-0
Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006
Fox E, 2012, DEV NEUROBIOL, V72, P1327, DOI 10.1002/dneu.22052
GARTY BZ, 1994, CLIN DIAGN LAB IMMUN, V1, P667
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Heininger U, 2006, VACCINE, V24, P3258, DOI 10.1016/j.vaccine.2006.01.026
Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
Martin LA, 2008, BRAIN BEHAV IMMUN, V22, P806, DOI 10.1016/j.bbi.2007.12.007
McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
Onore C, 2011, BRAIN BEHAV IMMUN
Saunders NR, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00046
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Singer HS, 2009, J NEUROIMMUNOL, V211, P39, DOI 10.1016/j.jneuroim.2009.03.011
Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
WEGMANN TG, 1993, IMMUNOL TODAY, V14, P353, DOI 10.1016/0167-5699(93)90235-D
Yang M., 2011, CURR PROTOC NEUROSCI, V56, P26
Zimmerman AW, 2007, BRAIN BEHAV IMMUN, V21, P351, DOI 10.1016/j.bbi.2006.08.005
NR 27
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUN 1
PY 2014
VL 266
BP 46
EP 51
DI 10.1016/j.bbr.2014.02.045
PG 6
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AH0JN
UT WOS:000335805300006
PM 24613242
ER
PT J
AU McKimm, E
Corkill, B
Goldowitz, D
Albritton, LM
Homayouni, R
Blaha, CD
Mittleman, G
AF McKimm, Eric
Corkill, Beau
Goldowitz, Dan
Albritton, Lorraine M.
Homayouni, Ramin
Blaha, Charles D.
Mittleman, Guy
TI Glutamate Dysfunction Associated with Developmental Cerebellar Damage:
Relevance to Autism Spectrum Disorders
SO CEREBELLUM
LA English
DT Article
DE Autism; Cerebellum; Dopamine; Glutamate; Fmr1 mice
ID LURCHER MUTANT MICE; QUANTITATIVE MORPHOLOGICAL ANALYSIS; PURKINJE-CELL
LOSS; PREFRONTAL CORTEX; NEUROANATOMICAL ABNORMALITIES; STEREOLOGICAL
EXPERIMENT; CHOLINERGIC NEURONS; ANTERIOR CINGULATE; DOPAMINE; RAT
AB Neural abnormalities commonly associated with autism spectrum disorders include prefrontal cortex (PFC) dysfunction and cerebellar pathology in the form of Purkinje cell loss and cerebellar hypoplasia. It has been reported that loss of cerebellar Purkinje cells results in aberrant dopamine neurotransmission in the PFC which occurs via dysregulation of multisynaptic efferents from the cerebellum to the PFC. Using a mouse model, we investigated the possibility that developmental cerebellar Purkinje cell loss could disrupt glutamatergic cerebellar projections to the PFC that ultimately modulate DA release. We measured glutamate release evoked by local electrical stimulation using fixed-potential amperometry in combination with glutamate selective enzyme-based recording probes in urethane-anesthetized Lurcher mutant and wildtype mice. Target sites included the mediodorsal and ventrolateral thalamic nuclei, reticulotegmental nuclei, pedunculopontine nuclei, and ventral tegmental area. With the exception of the ventral tegmental area, the results indicated that in comparison to wildtype mice, evoked glutamate release was reduced in Lurcher mutants by between 9 and 72 % at all stimulated sites. These results are consistent with the notion that developmental loss of cerebellar Purkinje cells drives reductions in evoked glutamate release in cerebellar efferent pathways that ultimately influence PFC dopamine release. Possible mechanisms whereby reductions in glutamate release could occur are discussed.
C1 [McKimm, Eric; Corkill, Beau; Blaha, Charles D.; Mittleman, Guy] Univ Memphis, Dept Psychol, Memphis, TN 38152 USA.
[Goldowitz, Dan] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC, Canada.
[Albritton, Lorraine M.] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA.
[Homayouni, Ramin] Univ Memphis, Bioinformat Program, Memphis, TN 38152 USA.
[Homayouni, Ramin] Univ Memphis, Ctr Translat Informat, Dept Biol, Memphis, TN 38152 USA.
RP Mittleman, G (reprint author), Univ Memphis, Dept Psychol, 400 Innovat Dr, Memphis, TN 38152 USA.
EM gmittlmn@memphis.edu
FU NINDS [1R01NS063009]
FX This project was made possible by NINDS grant 1R01NS063009.
CR Agnesi F, 2009, J NEUROSURG, V111, P701, DOI 10.3171/2009.3.JNS0990
Agnesi F, 2010, J NEURAL ENG, V7, P1
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Andreasen NC, 1998, SCHIZOPHRENIA BULL, V24, P203
Arckens L, 2000, EUR J NEUROSCI, V12, P4222, DOI 10.1046/j.0953-816X.2000.01328.x
BAUMAN ML, 1991, PEDIATRICS, V87, P791
Bolduc ME, 2011, DEV MED CHILD NEUROL, V53, P409, DOI 10.1111/j.1469-8749.2011.03929.x
CADDY KWT, 1979, PHILOS T ROY SOC B, V287, P167, DOI 10.1098/rstb.1979.0055
CARDER RK, 1994, J NEUROSCI, V14, P242
Carper RA, 2000, BRAIN, V123, P836, DOI 10.1093/brain/123.4.836
Centers for Disease Control and Prevention, 2007, MMWR SURVEILL SUMM, V56, P12
Chudasama Y, 2003, BEHAV BRAIN RES, V146, P105, DOI 10.1016/j.bbr.2003.09.020
COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
Courchesne E, 1997, CURR OPIN NEUROBIOL, V7, P269, DOI 10.1016/S0959-4388(97)80016-5
COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006
Dickson PE, 2010, NEUROBIOL LEARN MEM, V94, P220, DOI 10.1016/j.nlm.2010.05.010
Ernst M, 1997, LANCET, V350, P638, DOI 10.1016/S0140-6736(05)63326-0
Goldowitz Dan, 1992, V8, P271
HECKROTH JA, 1994, J COMP NEUROL, V343, P173, DOI 10.1002/cne.903430113
HECKROTH JA, 1994, J COMP NEUROL, V343, P183, DOI 10.1002/cne.903430114
Horder J, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.53
Kyriakopoulos M, 2008, BIOL PSYCHIAT, V63, P519, DOI 10.1016/j.biopsych.2007.05.021
LAVOIE B, 1994, J COMP NEUROL, V344, P190, DOI 10.1002/cne.903440203
Lee M, 2011, GLIA, V59, P152, DOI 10.1002/glia.21087
Limperopoulos C, 2012, CEREB CORTEX
Magnotta VA, 2008, PSYCHIAT RES-NEUROIM, V163, P193, DOI 10.1016/j.pscychresns.2007.10.005
Maloku E, 2010, P NATL ACAD SCI USA, V107, P4407, DOI 10.1073/pnas.0914483107
Martin LA, 2010, EUR J NEUROSCI, V31, P544, DOI 10.1111/j.1460-9568.2009.07073.x
Middleton FA, 2001, J NEUROSCI, V21, P700
Middleton FA, 2000, BRAIN RES REV, V31, P236, DOI 10.1016/S0165-0173(99)00040-5
Mittleman G, 2008, SYNAPSE, V62, P544, DOI 10.1002/syn.20525
Oakman SA, 1999, NEUROSCIENCE, V94, P529, DOI 10.1016/S0306-4522(99)00307-3
Ozonoff S, 2007, NEW DEV AUTISM FUTUR, P185
Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
Paxinos G, 2001, MOUSE BRAIN STEREOTA
Pinto A, 2003, J COMP NEUROL, V459, P142, DOI 10.1002/cne.10596
PIROT S, 1994, EUR J NEUROSCI, V6, P1225, DOI 10.1111/j.1460-9568.1994.tb00621.x
Robbins TW, 2009, ANNU REV NEUROSCI, V32, P267, DOI 10.1146/annurev.neuro.051508.135535
Rogers TD, 2011, SYNAPSE, V65, P1204, DOI 10.1002/syn.20960
Rogers TD, 2013, CEREBELLUM, V12, P547, DOI 10.1007/s12311-013-0462-2
Schwarz C, 1997, J COMP NEUROL, V381, P320, DOI 10.1002/(SICI)1096-9861(19970512)381:3<320::AID-CNE5>3.0.CO;2-4
Shimmura C, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-6
Strazielle C, 2000, J NEUROPATH EXP NEUR, V59, P707
Tehovnik EJ, 1996, J NEUROSCI METH, V65, P1, DOI 10.1016/0165-0270(95)00131-X
VERTES RP, 1986, NEUROSCIENCE, V19, P873, DOI 10.1016/0306-4522(86)90305-2
Whitney ER, 2008, J NEUROSCI METH, V168, P42, DOI 10.1016/j.jneumeth.2007.09.009
Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y
YEOMANS JS, 1988, BRAIN RES, V450, P86, DOI 10.1016/0006-8993(88)91547-8
Zuo J, 1997, NATURE, V388, P769
NR 51
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
EI 1473-4230
J9 CEREBELLUM
JI Cerebellum
PD JUN
PY 2014
VL 13
IS 3
BP 346
EP 353
DI 10.1007/s12311-013-0541-4
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA AG9LB
UT WOS:000335739600006
PM 24307139
ER
PT J
AU Brock, ME
Huber, HB
Carter, EW
Juarez, AP
Warren, ZE
AF Brock, Matthew E.
Huber, Heartley B.
Carter, Erik W.
Juarez, A. Pablo
Warren, Zachary E.
TI Statewide Assessment of Professional Development Needs Related to
Educating Students With Autism Spectrum Disorder
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism spectrum disorder; training needs; professional development;
training methods
ID IMPLEMENTATION SCIENCE; SCHOOL; TEACHERS; STRATEGIES; CHILDREN; YOUTH
AB Preparing teachers to implement evidence-based practices for students with autism spectrum disorder (ASD) is a pressing need. We surveyed 456 teachers and administrators in a southern state about professional development related to educating students with ASD. Specifically, we were interested in confidence in implementation of evidence-based practices, interest in accessing training on these topics, perceived benefit of different avenues of professional development, and interest in accessing these avenues. Overall, teachers were not very confident in their ability to implement evidence-based practices and address important issues for students with ASD. Surprisingly, lower confidence was not related to increased interest in training. In addition, teachers and administrators perceived workshops to be a more beneficial and attractive avenue of professional development compared with coaching, despite empirical evidence to the contrary. We offer possible explanations for these findings and share implications for administrators, technical assistance providers, and policy makers who make decisions about professional development opportunities.
C1 [Brock, Matthew E.; Huber, Heartley B.; Carter, Erik W.; Juarez, A. Pablo; Warren, Zachary E.] Vanderbilt Univ, Nashville, TN 37203 USA.
RP Brock, ME (reprint author), Vanderbilt Univ, Dept Special Educ, 230 Appleton Pl,PMB 228, Nashville, TN 37203 USA.
EM matthew.e.brock@vanderbilt.edu
CR Barnhill GP, 2011, FOCUS AUTISM DEV DIS, V26, P75, DOI 10.1177/1088357610378292
Barnhill GP, 2014, FOCUS AUTISM DEV DIS, V29, P39, DOI 10.1177/1088357612475294
Brock ME, 2015, J SPEC EDUC, V49, P39, DOI 10.1177/0022466913501882
Callahan K., 2013, INT M AUT RES SAN SE
Carter EW, 2013, AJIDD-AM J INTELLECT, V118, P16, DOI 10.1352/1944-7558-118.1.16
Cook BG, 2013, EXCEPT CHILDREN, V79, P163
Cook BG, 2008, INTERV SCH CLIN, V44, P69, DOI 10.1177/1053451208321452
Cook BG, 2013, EXCEPT CHILDREN, V79, P135
Garet MS, 2001, AM EDUC RES J, V38, P915, DOI 10.3102/00028312038004915
Hall LJ, 2010, BEHAV INTERVENT, V25, P37, DOI 10.1002/bin.294
Han SS, 2005, J ABNORM CHILD PSYCH, V33, P665, DOI 10.1007/s10802-005-7646-2
Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
Hart J. E., 2013, INT J SPECIAL ED, V28, P1
Hendricks D. R., 2011, J VOCATIONAL REHABIL, V35, P27, DOI [10.3233/JVR-2011-0552, DOI 10.3233/JVR-2011-0552]
Hendricks DR, 2009, FOCUS AUTISM DEV DIS, V24, P77, DOI 10.1177/1088357608329827
Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
Johnson LD, 2014, J SPEC EDUC, V48, P214, DOI 10.1177/0022466913475872
Klingner JK, 2013, EXCEPT CHILDREN, V79, P195
Kretlow A. G., 2010, TEACHER ED SPECIAL E, V33, P279, DOI [10.1177/0888406410371643, DOI 10.1177/0888406410371643]
Morrier M. J., 2011, TEACHER ED SPECIAL E, V34, P119, DOI DOI 10.1177/0888406410376660
National Autism Center, 2009, NAT STANDARDS REPORT
Odom S. L., 2010, PREVENTING SCH FAILU, V54, P275, DOI DOI 10.1080/10459881003785506
Odom SL, 2013, EXCEPT CHILDREN, V79, P233
Pennington RC, 2012, FOCUS AUTISM DEV DIS, V27, P158, DOI 10.1177/1088357612451318
Penuel WR, 2007, AM EDUC RES J, V44, P921, DOI 10.3102/0002831207308221
Ruble LA, 2011, FOCUS AUTISM DEV DIS, V26, P67, DOI 10.1177/1088357610397345
Russo A., 2004, HARVARD ED LETT, V20, P1
Sanford C., 2008, NATL PROFILE STUDENT
Segall MJ, 2012, RES AUTISM SPECT DIS, V6, P1156, DOI 10.1016/j.rasd.2012.02.007
Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
SMITH T, 1992, RES DEV DISABIL, V13, P57, DOI 10.1016/0891-4222(92)90040-D
Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
STEIN MK, 1988, TEACH TEACH EDUC, V4, P171, DOI 10.1016/0742-051X(88)90016-9
Wagner M., 2005, HIGH SCH 1 LOOK POST
Wilson K. P., 2012, EARLY CHILDHOOD ED J, V40, P97, DOI [10.1007/s10643-011-0493-6, DOI 10.1007/S10643-011-0493-6]
NR 36
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2014
VL 29
IS 2
BP 67
EP 79
DI 10.1177/1088357614522290
PG 13
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AG6ZZ
UT WOS:000335569000001
ER
PT J
AU White, SE
AF White, Stacy E.
TI Special Education Complaints Filed by Parents of Students With Autism
Spectrum Disorders in the Midwestern United States
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE legal cases; special education; autism spectrum disorders; complaint
investigations
ID YOUNG-CHILDREN; PROGRAMS; HEARINGS; QUALITY; SUPPORT
AB The number of students with autism spectrum disorders (ASD) receiving services in public schools is increasing steadily. However, the findings of previous research and recent litigation trends suggest that a notable disconnect persists between school-based services and parental satisfaction. As a means to better understand parental dissatisfaction with educational services, I analyzed presenting issues and outcomes of complaint investigations filed by parents of children with ASD in a midwestern U.S. state. A total of 97 electronic summaries of complaint investigations filed from January 2004 to January 2009 were examined using content analysis to identify the most frequently cited complaint issues, as well as the findings of fact leading to decisions in favor of schools. Common complaint issues included problems with Individualized Education Program content and implementation, parental participation, evaluation and case conference committee procedures, staff qualifications, and behavior/disciplinary procedures. Implications of the findings for educators, parents, and future research are discussed.
C1 [White, Stacy E.] Indiana Univ, Bloomington, IN 47405 USA.
RP White, SE (reprint author), Indiana Univ, WW Wright Sch Educ, 201 N Rose Ave, Bloomington, IN 47405 USA.
EM stacwhit@indiana.edu
CR Baird M. M., 1999, P 20 NAT I LEG ISS E
Chambers J. G., 2003, SPECIAL ED EXPENDITU
Etscheidt S, 2003, RES PRACT PERS SEV D, V28, P51, DOI 10.2511/rpsd.28.2.51
Fish W. W., 2006, EDUCATION, V127, P56
Hall LJ, 2010, BEHAV INTERVENT, V25, P37, DOI 10.1002/bin.294
Ketterlin-Geller LR, 2007, REM SPEC EDUC, V28, P194, DOI 10.1177/07419325070280040101
King G, 2009, FOCUS AUTISM DEV DIS, V24, P50, DOI 10.1177/1088357608329173
Kraemer BR, 2008, J POSIT BEHAV INTERV, V10, P179, DOI 10.1177/1098300708318796
Lake JF, 2000, REM SPEC EDUC, V21, P240, DOI 10.1177/074193250002100407
Lord C., 2001, DIV BEH SOC SCI ED
Mandlawitz MR, 2002, J AUTISM DEV DISORD, V32, P495, DOI 10.1023/A:1020502324718
Merriam Sharan, 2009, QUALITATIVE RES GUID, Vsecond
Montes Guillermo, 2009, Pediatrics, V124 Suppl 4, pS407, DOI 10.1542/peds.2009-1255L
National Autism Center, 2009, NAT STAND REP
Renty J, 2006, CHILD CARE HLTH DEV, V32, P371, DOI 10.1111/j.1365-2214.2006.00584.x
Ruble LA, 2010, J AUTISM DEV DISORD, V40, P1459, DOI 10.1007/s10803-010-1003-1
Scheuermann B., 2003, FOCUS AUTISM OTHER D, V18, P197, DOI DOI 10.1177/10883576030180030801
Spann S. J., 2003, FOCUS AUTISM OTHER D, V18, P228, DOI DOI 10.1177/10883576030180040401
Stoner J., 2006, FOCUS AUTISM OTHER D, V21, P177, DOI 10.1177/10883576060210030601
Stoner J. B., 2005, FOCUS AUTISM OTHER D, V20, P39, DOI DOI 10.1177/10883576050200010401
Wilczynski SM, 2007, PSYCHOL SCHOOLS, V44, P653, DOI 10.1002/pits
Williams ME, 2009, J AUTISM DEV DISORD, V39, P660, DOI 10.1007/s10803-008-0668-1
Yell M., 2003, FOCUS AUTISM OTHER D, V18, P182, DOI DOI 10.1177/10883576030180030601
Yell ML, 2000, J SPEC EDUC, V33, P205, DOI 10.1177/002246690003300403
Zirkel P., 2002, FOCUS AUTISM OTHER D, V17, P84, DOI 10.1177/10883576020170020301
NR 25
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2014
VL 29
IS 2
BP 80
EP 87
DI 10.1177/1088357613478830
PG 8
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AG6ZZ
UT WOS:000335569000002
ER
PT J
AU Chiang, HM
AF Chiang, Hsu-Min
TI A Parent Education Program for Parents of Chinese American Children With
Autism Spectrum Disorders (ASDs) A Pilot Study
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE multicultural issues; evidence-based practices; intervention; parent;
autism
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; HISPANIC ADOLESCENTS;
INTERACTION THERAPY; CENTERED APPROACH; YOUNG-CHILDREN; MENTAL-HEALTH;
HONG-KONG; FAMILIES; MOTHERS
AB This study was conducted to examine the effectiveness of a parent education program on decreasing parenting stress and increasing parental confidence and quality of life in parents of Chinese American children with autism spectrum disorders (ASDs). A pre-, posttest group design was used in this study. A total of nine families of Chinese American children with ASDs participated in a 10-week parent education program (including 10-weekly 120-min group sessions). The findings of this study revealed that after receiving the program, parents of Chinese American children with ASDs showed significant reduction in parenting stress, improvement in parental confidence, and improvement in quality of life in physical health and environment domains.
C1 [Chiang, Hsu-Min] Columbia Univ, New York, NY 10027 USA.
RP Chiang, HM (reprint author), Columbia Univ, Teachers Coll, Special Educ Program, Box 223, New York, NY 10027 USA.
EM hchiang@tc.edu
CR Abidin R. R., 1995, PSYCHOL ASSESSMENT R
Anan RM, 2008, BEHAV INTERVENT, V23, P165, DOI 10.1002/bin.262
Blackledge JT, 2006, CHILD FAM BEHAV THER, V28, P1, DOI 10.1300/J019v28n01_01
Brookman-Frazee L, 2004, J POSIT BEHAV INTERV, V6, P195, DOI 10.1177/10983007040060040201
Callicott K. J., 2003, FOCUS AUTISM OTHER D, V18, P60, DOI 10.1177/108835760301800108
Cappe E, 2011, QUAL LIFE RES, V20, P1279, DOI 10.1007/s11136-011-9861-3
Carpentier F. D., 2007, J PRIM PREV, V28, P521, DOI [10.1007/s10935-007-0110-z, DOI 10.1007/S10935-007-0110-Z]
Chiang L. H., 2007, INT J SPECIAL ED, V22, P19
Dempsey I, 2009, RES DEV DISABIL, V30, P558, DOI 10.1016/j.ridd.2008.08.005
Dunst C. J., 2002, J SPEC EDUC, V36, P141, DOI [10.1177/00224669020360030401, DOI 10.1177/00224669020360030401]
Dunst CJ, 2007, MENT RETARD DEV D R, V13, P370, DOI 10.1002/mrdd.20176
Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
Johnson N, 2011, FAM SYST HEALTH, V29, P232, DOI 10.1037/a0025341
KAZDIN AE, 1993, DEV PSYCHOPATHOL, V5, P277, DOI 10.1017/S0954579400004399
Keen D, 2010, RES AUTISM SPECT DIS, V4, P229, DOI 10.1016/j.rasd.2009.09.009
Khanna R, 2011, J AUTISM DEV DISORD, V41, P1214, DOI 10.1007/s10803-010-1140-6
Kung WW, 2004, J COMMUNITY PSYCHOL, V32, P27, DOI 10.1002/jcop.10077
Ling CYM, 2010, J APPL RES INTELLECT, V23, P237, DOI 10.1111/j.1468-3148.2008.00456.x
Mak WWS, 2007, J APPL RES INTELLECT, V20, P157, DOI 10.1111/j.1468-3148.2006.00315.x
Matos M, 2009, FAM PROCESS, V48, P232
McCabe K, 2009, J CLIN CHILD ADOLESC, V38, P753, DOI 10.1080/15374410903103544
McConachie H, 2005, J PEDIATR-US, V147, P335, DOI 10.1016/j.jpeds.2005.03.056
McConkey R, 2012, J INTELL DISABIL RES, V56, P736
Minjarez MB, 2011, J AUTISM DEV DISORD, V41, P92, DOI 10.1007/s10803-010-1027-6
Okuno H, 2011, BRAIN DEV-JPN, V33, P152, DOI 10.1016/j.braindev.2010.03.007
Orrell-Valente JK, 1999, AM J COMMUN PSYCHOL, V27, P753, DOI 10.1023/A:1022258525075
Osborne LA, 2010, RES AUTISM SPECT DIS, V4, P405, DOI 10.1016/j.rasd.2009.10.011
Pantin H, 2003, HISPANIC J BEHAV SCI, V25, P469, DOI 10.1177/0739986303259355
Prado G, 2006, J PEDIATR PSYCHOL, V31, P874, DOI 10.1093/jpepsy/jsj046
Schultz TR, 2011, FOCUS AUTISM DEV DIS, V26, P96, DOI 10.1177/1088357610397346
Shu BC, 2009, AUTISM, V13, P81, DOI 10.1177/1362361307098517
Silva LMT, 2012, J AUTISM DEV DISORD, V42, P566, DOI 10.1007/s10803-011-1274-1
Skevington SM, 2004, QUAL LIFE RES, V13, P299, DOI 10.1023/B:QURE.0000018486.91360.00
Sofronoff K, 2011, RES DEV DISABIL, V32, P2253, DOI 10.1016/j.ridd.2011.07.046
Tapia MI, 2006, RES SOCIAL WORK PRAC, V16, P146, DOI 10.1177/1049731505282205
Harper A, 1998, PSYCHOL MED, V28, P551
Todd S, 2010, CHILD ADOL MENT H-UK, V15, P171, DOI 10.1111/j.1475-3588.2009.00553.x
Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
Weaver SR, 2008, J YOUTH ADOLESCENCE, V37, P36, DOI 10.1007/s10964-007-9221-3
Welterlin A, 2007, DISABIL SOC, V22, P747, DOI 10.1080/09687590701659600
NR 40
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2014
VL 29
IS 2
BP 88
EP 94
DI 10.1177/1088357613504990
PG 7
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AG6ZZ
UT WOS:000335569000003
ER
PT J
AU Meadan, H
Angell, ME
Stoner, JB
Daczewitz, ME
AF Meadan, Hedda
Angell, Maureen E.
Stoner, Julia B.
Daczewitz, Marcus E.
TI Parent-Implemented Social-Pragmatic Communication Intervention A Pilot
Study
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE visual teaching strategies; young children with Down syndrome; parent
interventionists; naturalistic teaching strategies
ID AUTISM SPECTRUM DISORDERS; EDUCATION-PROGRAMS; TRAINING-PROGRAM;
CHILDREN; LANGUAGE; ACQUISITION; TEACHERS; PLAY
AB This pilot study investigated the feasibility and effectiveness of a home-based parent training and coaching program on the use of naturalistic and visual teaching strategies by parents of children (aged 2-5 years) with Down syndrome to promote and enhance these children's social-pragmatic communication skills. Five parent interventionist-child dyads participated. A single-case multiple-baseline design demonstrated the feasibility and effectiveness of the parent training and coaching program on parents' correct use of naturalistic and visual teaching strategies. Findings suggest that parents and children benefited from the intervention. Parents learned the new teaching strategies, implemented them with high fidelity, and were satisfied with intervention procedures and outcomes. In addition, parents reported improvement in their children's social-pragmatic communication skills. Implications for practice and future research are described.
C1 [Meadan, Hedda] Univ Illinois, Champaign, IL 61820 USA.
[Angell, Maureen E.; Stoner, Julia B.; Daczewitz, Marcus E.] Illinois State Univ, Normal, IL 61761 USA.
RP Meadan, H (reprint author), Univ Illinois, Dept Special Educ, 1310 S Sixth St, Champaign, IL 61820 USA.
EM meadan@illinois.edu
CR ALPERT CL, 1992, J EARLY INTERVENTION, V16, P31
Arthur-Kelly M, 2009, DISABIL REHABIL, V31, P1474, DOI 10.1080/09638280802590629
Brookman-Frazee L, 2004, J POSIT BEHAV INTERV, V6, P195, DOI 10.1177/10983007040060040201
Bruder MB, 2010, EXCEPT CHILDREN, V76, P339
BRUNER JS, 1975, COGNITION, V3, P255, DOI 10.1016/0010-0277(74)90012-2
Dunlap G, 2006, J EARLY INTERVENTION, V28, P81, DOI 10.1177/105381510602800201
FARRAR MJ, 1990, J CHILD LANG, V17, P607
Ganz J. B., 2010, YOUNG EXCEPTIONAL CH, V13, P58, DOI DOI 10.1177/1096250609351795
Ganz JB, 2008, J AUTISM DEV DISORD, V38, P926, DOI 10.1007/s10803-007-0463-4
Gast D. L., 2010, SINGLE SUBJECT RES M
Gray C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1, DOI DOI 10.1177/108835769300800101
Halle J. W., 1982, J ASS SEVERELY HANDI, V7, P29
HAMPSON J, 1993, J CHILD LANG, V20, P313
Hancock TB, 2006, TREATMENT LANGUAGE D, P203
HART B, 1975, J APPL BEHAV ANAL, V8, P411, DOI 10.1901/jaba.1975.8-411
Heflin L. J., 1998, FOCUS AUTISM OTHER D, V13, P212
HEMMETER ML, 1994, J EARLY INTERVENTION, V18, P269
Kaiser A. P., 2000, J EARLY ED DEV, V4, P423
Kaminski JW, 2008, J ABNORM CHILD PSYCH, V36, P567, DOI 10.1007/s10802-007-9201-9
Kashinath S, 2006, J SPEECH LANG HEAR R, V49, P466, DOI 10.1044/1092-4388(2006/036)
Kazdin A. E., 2011, SINGLE CASE RES DESI
Keen D, 2007, AUTISM, V11, P63, DOI 10.1177/1362361307070901
Koegel RL, 1996, J AUTISM DEV DISORD, V26, P347, DOI 10.1007/BF02172479
Kretlow AG, 2011, J SPEC EDUC, V44, P234, DOI 10.1177/0022466909341333
Levinson Stephen C., 1983, PRAGMATICS
McLean J., 1978, T APPROACH EARLY LAN
Mobayed K., 2000, J EARLY INTERVENTION, V23, P165, DOI DOI 10.1177/10538151000230030601
Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
Ostrosky M. M, 1991, TEACHING EXCEPTIONAL, V23, P6
Prizant B. M., 1997, HDB AUTISM PERVASIVE, P572
Prizant Barry, 1998, Seminars in Speech and Language, V19, P329, DOI 10.1055/s-2008-1064053
Quill K. A., 1995, FOCUS AUTISTIC BEHAV, V10, P10, DOI DOI 10.1177/108835769501000302
Roberts MY, 2011, AM J SPEECH-LANG PAT, V20, P180, DOI 10.1044/1058-0360(2011/10-0055)
Rogers-Warren A. K., 1985, TEACHING FUNCTIONAL, P63
Sameroff AJ, 1975, REV CHILD DEV RES, P187
Schuler A. L., 1997, HDB AUTISM PERVASIVE, P539
Schultz TR, 2011, FOCUS AUTISM DEV DIS, V26, P96, DOI 10.1177/1088357610397346
Sigafoos J., 2006, ENHANCING EVERYDAY C
Smith T, 2000, RES DEV DISABIL, V21, P297, DOI 10.1016/S0891-4222(00)00043-3
Stoner J. B., 2013, PERSPECTIVES LANGUAG, V20, P112, DOI [10.1044/lle20.3.112, DOI 10.1044/LLE20.3.112]
TAPP J, 1995, BEHAV RES METH INSTR, V27, P25, DOI 10.3758/BF03203616
Tapp J. T., 2003, PROCODERDV COMPUTER
Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
Turan Y., 2011, YOUNG EXCEPTIONAL CH, V14, P13, DOI 10.1177/1096250611415812
Wetherby A. M., 1997, HDB AUTISM PERVASIVE, P513
WOLF MM, 1978, J APPL BEHAV ANAL, V11, P203, DOI 10.1901/jaba.1978.11-203
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 47
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2014
VL 29
IS 2
BP 95
EP 110
DI 10.1177/1088357613517504
PG 16
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AG6ZZ
UT WOS:000335569000004
ER
PT J
AU Hebert, EB
AF Hebert, Elizabeth Baltus
TI Factors Affecting Parental Decision-Making Regarding Interventions for
Their Child With Autism
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE choice; autism spectrum disorders; parent
ID SPECTRUM DISORDERS; ALTERNATIVE MEDICINE; DOWN-SYNDROME; COMPLEMENTARY;
FAMILIES; CARE; DISABILITY; PRESCHOOL; PATTERNS; MOTHERS
AB Due to the numerous interventions available for children with autism, parents are faced with challenging decisions regarding treatments from the time of diagnosis and throughout their child's life. This exploratory qualitative study investigated the reasons behind parents' decisions about interventions for their child with autism. In-depth interviews were conducted with 23 parents from 18 families making decisions for 19 young children to understand their perspectives on deciding a philosophical approach, choosing a preschool program, and/or deciding on alternative treatments. Children had a diagnosis of pervasive developmental disorder not otherwise specified or autistic disorder and were below the age of 7 years. Parents' considerations were categorized into the themes of parental, child, and program attributes. Recommendations were made regarding areas to explore with families to provide support as they weigh the numerous options available. Recommendations for policy changes that could improve diagnostic and treatment services for children with autism and their families were discussed.
C1 [Hebert, Elizabeth Baltus] Nazareth Coll, Rochester, NY 14618 USA.
RP Hebert, EB (reprint author), Nazareth Coll, Occupat Therapy Dept, 4245 East Ave, Rochester, NY 14618 USA.
EM LizBHebert@yahoo.com
CR Al Anbar NN, 2010, RES DEV DISABIL, V31, P817, DOI 10.1016/j.ridd.2010.02.007
American Academy of Pediatrics, 2001, PEDIATRICS, V17, P598
Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
Autism Speaks, 2012, MEDICATION DECISION
Autism Speaks, 2008, 1 100 DAYS KIT
Avdi E, 2000, J Health Psychol, V5, P241, DOI 10.1177/135910530000500214
BAUMRIND D, 1967, GENET PSYCHOL MONOGR, V75, P43
Braddock David L., 2001, HDB DISABILITY STUDI, p[11, 14]
Charmaz K., 2006, CONSTRUCTING GROUNDE
Cooper J. O., 2007, APPL BEHAV ANAL
Corbin J., 2008, BASICS QUALITATIVE R, V3rd
Daniel E, 2005, BRIT J HEALTH PSYCH, V10, P101, DOI 10.1348/135910704X14609
Dardennes RM, 2011, RES DEV DISABIL, V32, P1137, DOI 10.1016/j.ridd.2011.01.010
Duffy M., 2007, NURSING RES QUALITAT, P401
Elder J H, 1994, J Child Adolesc Psychiatr Nurs, V7, P9, DOI 10.1111/j.1744-6171.1994.tb00184.x
Fisher P, 2007, SOCIOL HEALTH ILL, V29, P66, DOI 10.1111/j.1467-9566.2007.00518.x
Gau SSF, 2010, PSYCHIAT CLIN NEUROS, V64, P70, DOI 10.1111/j.1440-1819.2009.02034.x
Golnik A, 2012, INTELLECT DEV DISAB, V50, P322, DOI 10.1352/1934-9556-50.4.322
Gray E. G., 1995, MED ANTHROPOL, V16, P99
Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
Green VA, 2007, J DEV PHYS DISABIL, V19, P91, DOI 10.1007/s10882-007-9035-y
Guerriere DN, 2003, DEV MED CHILD NEUROL, V45, P470, DOI 10.1017/S0012162203000872
Hall S., 2012, DISS ABSTR INT A, V73, P874
Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
Harrington JW, 2006, AUTISM, V10, P452, DOI 10.1177/1362361306066609
Harrington JW, 2006, J DEV BEHAV PEDIATR, V27, pS156, DOI 10.1097/00004703-200604002-00014
Holloway I., 2010, QUALITATIVE RES NURS, V3rd
Hyman S., 2000, CONT PEDIAT, V17, P100
Jegatheesan B, 2010, FOCUS AUTISM DEV DIS, V25, P98, DOI 10.1177/1088357610361344
Kemper KJ, 2008, PEDIATRICS, V122, P1374, DOI 10.1542/peds.2008-2173
King G, 2009, FOCUS AUTISM DEV DIS, V24, P50, DOI 10.1177/1088357608329173
KONSTANTAREAS M, 1995, J AUTISM DEV DISORD, V25, P443, DOI 10.1007/BF02179378
Kvale Steinar, 2007, DOING INTERVIEWS
Landsman Gail, 2005, J Med Humanit, V26, P121, DOI 10.1007/s10912-005-2914-2
Mandell DS, 2005, MENT RETARD DEV D R, V11, P110, DOI 10.1002/mrdd.20061
Marshall Catherine, 2011, DESIGNING QUALITATIV, V5th
Miller VA, 2012, RES AUTISM SPECT DIS, V6, P87, DOI 10.1016/j.rasd.2011.03.008
Mruzek D., 2009, INT M AUT RES CHIC I
O'Connor AM, 2004, HEALTH AFFAIR, V23, pVAR63, DOI 10.1377/hlthaff.var.63
O'Keefe M, 2010, J PAEDIATR CHILD H, V46, P296, DOI 10.1111/j.1440-1754.2010.01711.x
Prussing E, 2005, SOC SCI MED, V60, P587, DOI 10.1016/j.socscimed.2004.05.020
QSR, 2011, NVIVO 9
Romanczyk R. G., 2005, AUTISM SPECTRUM DISO, P515
Rutgers AH, 2007, J ABNORM CHILD PSYCH, V35, P859, DOI 10.1007/s10802-007-9139-y
Seidman I., 1998, INTERVIEWING QUALITA
Shyu YIL, 2010, J AUTISM DEV DISORD, V40, P1323, DOI 10.1007/s10803-010-0991-1
Stake R.E., 1995, ART CASE STUDY RES
Stoner J. B., 2005, FOCUS AUTISM OTHER D, V20, P39, DOI DOI 10.1177/10883576050200010401
Taylor M., 2006, INT J DISABIL DEV ED, V53, P111, DOI DOI 10.1080/10349120500510115
Tzanakaki P, 2012, EDUC TRAIN AUTISM DE, V47, P58
Volkmar FR, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P365, DOI 10.1007/978-1-4419-6975-0_14
Wieder S., 2009, ENGAGING AUTISM USIN
Wong HHL, 2006, J AUTISM DEV DISORD, V36, P901, DOI 10.1007/s10803-006-0131-0
Woolfson L, 2006, CHILD CARE HLTH DEV, V32, P177, DOI 10.1111/j.1365-2214.2006.00603.x
NR 54
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2014
VL 29
IS 2
BP 111
EP 124
DI 10.1177/1088357614522291
PG 14
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AG6ZZ
UT WOS:000335569000005
ER
PT J
AU Mammarella, IC
Giofre, D
Caviola, S
Cornoldi, C
Hamilton, C
AF Mammarella, Irene C.
Giofre, David
Caviola, Sara
Cornoldi, Cesare
Hamilton, Colin
TI Visuospatial working memory in children with autism: The effect of a
semantic global organization
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism Spectrum Disorder (ASD); Visuospatial working memory (VSWM);
Central coherence theory; Semantic organization
ID SHORT-TERM-MEMORY; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS;
INDIVIDUALS; CONSOLIDATION; ADOLESCENTS; CONTRIBUTES; INFORMATION;
PERFORMANCE; PERCEPTION
AB It has been reported that individuals with Autism Spectrum Disorders (ASD) perceive visual scenes as a sparse set of details rather than as a congruent and meaningful unit, failing in the extraction of the global configuration of the scene. In the present study, children with ASD were compared with typically developing (TD) children, in a visuospatial working memory task, the Visual Patterns Test (VPT). The VPT array was manipulated to vary the semantic affordance of the pattern, high semantic (global) vs. low semantic; temporal parameters were also manipulated within the change detection protocol. Overall, there was no main effect associated with Group, however there was a significant effect associated with Semantics, which was further qualified by an interaction between the Group and Semantic factors; there was only a significant effect of semantics in the TD group. The findings are discussed in light of the weak central coherence theory where the ASD group are unable to make use of long term memory semantics in order to construct global representations of the array. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Mammarella, Irene C.; Caviola, Sara] Univ Padua, Dept Dev & Social Psychol, I-35131 Padua, Italy.
[Giofre, David; Cornoldi, Cesare] Univ Padua, Dept Gen Psychol, I-35131 Padua, Italy.
[Hamilton, Colin] Northumbria Univ, Dept Psychol, Newcastle Upon Tyne, Tyne & Wear, England.
RP Mammarella, IC (reprint author), Univ Padua, Dept Dev & Social Psychol, Via Venezia 8, I-35131 Padua, Italy.
EM irene.mammarella@unipd.it
RI GIOFRE', DAVID/A-8788-2013
OI GIOFRE', DAVID/0000-0002-1992-6271
CR Alvarez GA, 2004, PSYCHOL SCI, V15, P106, DOI 10.1111/j.0963-7214.2004.01502006.x
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
ATTWOOD A, 1988, J AUTISM DEV DISORD, V18, P241, DOI 10.1007/BF02211950
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Belacchi C, 2011, BRIT J DEV PSYCHOL, V29, P942, DOI 10.1111/j.2044-835X.2011.02030.x
Bernardino I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039351
Brown LA, 2006, Q J EXP PSYCHOL, V59, P1169, DOI 10.1080/17470210600665954
Brown LA, 2013, J COGN PSYCHOL, V25, P328, DOI 10.1080/20445911.2013.773004
Carretti B, 2013, RES DEV DISABIL, V34, P669, DOI 10.1016/j.ridd.2012.09.011
Cornoldi C, 2003, ESSAYS COGN PSYCHOL, P1
Darling S, 2010, Q J EXP PSYCHOL, V63, P239, DOI 10.1080/17470210903348605
de Jonge M, 2009, EUR CHILD ADOLES PSY, V18, P197, DOI 10.1007/s00787-008-0708-6
Della Sala S, 1999, NEUROPSYCHOLOGIA, V37, P1189, DOI 10.1016/S0028-3932(98)00159-6
Fernell E, 2010, RES DEV DISABIL, V31, P680, DOI 10.1016/j.ridd.2010.01.007
Frith U., 1989, AUTISM EXPLAINING EN
Frith U, 2012, Q J EXP PSYCHOL, V65, P2073, DOI 10.1080/17470218.2012.697178
Gobet F, 1996, COGNITIVE PSYCHOL, V31, P1, DOI 10.1006/cogp.1996.0011
Gray C., 1997, VISUAL PATTERNS TEST
Griffith EM, 1999, CHILD DEV, V70, P817, DOI 10.1111/1467-8624.00059
Hamilton AFD, 2009, COGNITION, V113, P37, DOI 10.1016/j.cognition.2009.07.007
Hoppe F., 2001, J CHILD PSYCHOL PSYC, V42, P299
Hoppe F., 2006, J AUTISM DEV DISORD, V36, P5
Hulme C., 1992, WORKING MEMORY SEVER
Kuschner ES, 2009, AUTISM RES, V2, P348, DOI 10.1002/aur.101
Leonard H, 2010, RES AUTISM SPECT DIS, V4, P548, DOI 10.1016/j.rasd.2010.01.003
Logie R. H., 1995, VISUOSPATIAL WORKING
Massironi M., 2001, PSICOLOGICA, V22, P115
McMorris CA, 2013, J AUTISM DEV DISORD, V43, P1956, DOI 10.1007/s10803-012-1748-9
Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Orme E., 2014, SEMANTIC ELABO UNPUB
Ozonoff S, 2001, J AUTISM DEV DISORD, V31, P257, DOI 10.1023/A:1010794902139
Rennig J, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00513
Riby LM, 2013, BRAIN COGNITION, V81, P215, DOI 10.1016/j.bandc.2012.10.011
Richmond LL, 2013, Q J EXP PSYCHOL, V66, P1182, DOI 10.1080/17470218.2012.734831
Sanders J, 2008, RES AUTISM SPECT DIS, V2, P1, DOI 10.1016/j.rasd.2007.03.005
SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
SODIAN B, 1992, J CHILD PSYCHOL PSYC, V33, P591, DOI 10.1111/j.1469-7610.1992.tb00893.x
Soulieres I, 2011, NEUROPSYCHOLOGIA, V49, P848, DOI 10.1016/j.neuropsychologia.2011.01.027
Sun HM, 2011, Q J EXP PSYCHOL, V64, P707, DOI 10.1080/17470218.2010.511238
Takahashi J, 2013, J AUTISM DEV DISORD, V43, P1725, DOI 10.1007/s10803-012-1711-9
Vogel EK, 2006, J EXP PSYCHOL HUMAN, V32, P1436, DOI 10.1037/0096-1523.32.6.1436
Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21
NR 44
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUN
PY 2014
VL 35
IS 6
BP 1349
EP 1356
DI 10.1016/j.ridd.2014.03.030
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AG7YQ
UT WOS:000335635100017
PM 24705488
ER
PT J
AU Harrington, C
Foster, M
Rodger, S
Ashburner, J
AF Harrington, Caitlin
Foster, Michele
Rodger, Sylvia
Ashburner, Jill
TI Engaging young people with Autism Spectrum Disorder in research
interviews
SO BRITISH JOURNAL OF LEARNING DISABILITIES
LA English
DT Article
DE methodology; Asperger Syndrome; young people; qualitative; interviews;
autism
ID ASPERGER-SYNDROME; CHILDREN; EXPERIENCE; LANGUAGE; MEMORY; CHALLENGES;
DIFFERENCE; VIEWS
AB Accessible summary
Listening to young people with autism spectrum disorder is important.
Researchers can help support young people to have their say.
Each young person is different. The supports used need to match their needs.
This study draws on the first author's doctoral research on the mainstream schooling experiences of young people with autism spectrum disorder (ASD) and their parents in Queensland, Australia. The aims are to share some of the practical strategies that were adapted and developed to engage the young people in the research and to critically reflect on what this means for future inclusive methodological approaches in this area. The key message is that diagnostic-related assumptions about impairments can lead researchers to develop strategies which exclude or restrict rather than maximise participation of disabled people in research. To enable young people with ASD to provide rich and meaningful insights researchers need to acknowledge and plan creatively and flexibly for the interactive dynamic that is unique to each individual as well as for needs which might be shared.
C1 [Harrington, Caitlin; Foster, Michele] Univ Queensland, Social Work Serv, St Lucia, Qld 4072, Australia.
[Harrington, Caitlin; Foster, Michele] Univ Queensland, Human Serv, St Lucia, Qld 4072, Australia.
[Rodger, Sylvia; Ashburner, Jill] Univ Queensland, Sch Hlth & Rehabil Sci, St Lucia, Qld 4072, Australia.
RP Harrington, C (reprint author), Univ Queensland, Social Work Serv, St Lucia, Qld 4072, Australia.
EM caitlin.harrington@uqconnect.edu.au
CR Allred S, 2009, DISABIL SOC, V24, P343, DOI 10.1080/09687590902789511
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Arthur-Kelly M, 2009, DISABIL REHABIL, V31, P1474, DOI 10.1080/09638280802590629
Ashburner J., 2012, UNDERSTANDING UNPUB
Baron- Cohen S., 2002, FOCUS AUTISM OTHER D, V17, P186, DOI 10.1177/10883576020170030801
Beresford B., 2004, BRIT J LEARN DISABIL, V32, P180, DOI 10.1111/j.1468-3156.2004.00318.x
Beresford B, 1997, PERSONAL ACCOUNTS IN
Bishton H, 2011, STUDENT VOICE HANDBOOK: BRIDGING THE ACADEMIC/PRACTITIONER DIVIDE, P169
Brown BT, 2012, J AUTISM DEV DISORD, V42, P441, DOI 10.1007/s10803-011-1246-5
Bruck M, 2007, DEV PSYCHOPATHOL, V19, P73, DOI 10.1017/S0954579407070058
Connor D. J., 2011, INT J INCLUSIVE EDUC, V17, P111
Dettmer S., 2000, FOCUS AUTISM OTHER D, V15, P163, DOI DOI 10.1177/108835760001500307
Dockrell J. E., 2011, LISTENING YOUNG PEOP
Gray C., 1994, COMIC STRIP CONVERSA
Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
James A., 1998, THEORIZING CHILDHOOD
Jordan R, 2005, Pediatr Rehabil, V8, P104
Jordan R, 1999, AUTISM INT J RES PRA, V3, P411, DOI 10.1177/1362361399003004008
Kelly B., 2007, INT J SOC RES METHOD, V10, P21, DOI 10.1080/13645570600655159
Lewis A, 2009, J RELIG DISABIL HLTH, V13, P64
Lewis A, 2001, JORSEN, V1
Lewis A., 2000, RES CHILDRENS PERSPE
Lewis A., 2004, BRIT J LEARN DISABIL, V32, P191, DOI [10.1111/j.1468-3156.2004.00313.x, DOI 10.1111/J.1468-3156.2004.00313.X]
Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809
Martin I, 2004, J AUTISM DEV DISORD, V34, P311, DOI 10.1023/B:JADD.0000029553.52889.15
Millward C, 2000, J AUTISM DEV DISORD, V30, P15, DOI 10.1023/A:1005455926727
Mitchell P, 1997, J CHILD PSYCHOL PSYC, V38, P685, DOI 10.1111/j.1469-7610.1997.tb01695.x
Molloy H, 2002, DISABIL SOC, V17, P659, DOI 10.1080/0968759022000010434
Morris J, 2003, CHILDREN SOC, V17, P337, DOI DOI 10.1002/CHI754
Morris J, 2002, LOT SAY GUIDE SOCIAL
Myles BS, 2005, CHILDREN YOUTH ASPER
Norwich B., 1996, BRIT J SPECIAL ED, V23, P100, DOI 10.1111/j.1467-8578.1996.tb00957.x
Owen R., 2004, CHILD LANG TEACH THE, V20, P55, DOI 10.1191/0265659004ct263oa
Preece D, 2010, BRIT J LEARN DISABIL, V38, P10, DOI 10.1111/j.1468-3156.2009.00548.x
Preece D., 2002, BRIT J LEARN DISABIL, V30, P97, DOI 10.1046/j.1468-3156.2002.00179.x
Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
Ramcharan P, 2006, J INTELLECT DEV DIS, V31, P183, DOI 10.1080/13668250600876418
Saalasti S, 2008, J AUTISM DEV DISORD, V38, P1574, DOI 10.1007/s10803-008-0540-3
Wheeler M, 2011, DISABIL SOC, V26, P839, DOI 10.1080/09687599.2011.618739
Whitehurst T., 2007, BR J LEARN DISABIL, V35, P55, DOI 10.1111/j.1468-3156.2006.00405.x
NR 40
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1354-4187
EI 1468-3156
J9 BRIT J LEARN DISABIL
JI Brit. J. Learn. Disabil.
PD JUN
PY 2014
VL 42
IS 2
BP 153
EP 161
DI 10.1111/bld.12037
PG 9
WC Education, Special
SC Education & Educational Research
GA AF9AS
UT WOS:000335007900008
ER
PT J
AU Pritchard, D
Hoerger, M
Dyer, T
Graham, N
Penney, H
Mace, FC
AF Pritchard, Duncan
Hoerger, Marguerite
Dyer, Tim
Graham, Nicola
Penney, Heather
Mace, F. Charles
TI Sodium valproate withdrawal correlates with reduced aggression
SO BRITISH JOURNAL OF LEARNING DISABILITIES
LA English
DT Article
DE bipolar disorder; Aggression; sodium valproate; learning disability
ID INTELLECTUAL DISABILITIES; COGNITIVE THERAPY; PSYCHOTROPIC MEDICATION;
RESIDENTIAL FACILITIES; LEARNING-DISABILITIES; BEHAVIOR; PEOPLE;
POPULATION; ADULTS; INDIVIDUALS
AB Accessible
A 16-year-old boy diagnosed with a mild learning disability, atypical autism, attention-deficit hyperactivity disorder, bipolar disorder, conduct disorder and epilepsy was admitted to a residential special school for treatment of severe aggression.
Prior to admission, he had been prescribed various psychotropic medications, including sodium valproate, to treat his aggressive behaviour, bipolar disorder and epilepsy.
His behaviour improved when his medication was stopped.
People with learning disabilities are sometimes prescribed psychotropic medication to help manage their challenging behaviour. This case study describes how a multicomponent behavioural intervention in conjunction with the systematic withdrawal of sodium valproate was strongly correlated with reduced aggression. No symptoms of bipolar disorder or epilepsy were observed over the course of this 135-week case study. No aggression was observed during the last 20weeks of the study. Aggressive behaviour as a possible side effect of sodium valproate should be considered in people with learning disabilities.
C1 [Pritchard, Duncan; Dyer, Tim; Graham, Nicola; Penney, Heather] Aran Hall Sch, Dolgellau LL40 2AR, Gwynedd, Wales.
[Pritchard, Duncan] Bangor Univ, Dolgellau LL40 2AR, Gwynedd, Wales.
[Hoerger, Marguerite] Bangor Univ, Bangor, Gwynedd, Wales.
[Mace, F. Charles] Nova SE Univ, Ft Lauderdale, FL 33314 USA.
RP Pritchard, D (reprint author), Aran Hall Sch, Dolgellau LL40 2AR, Gwynedd, Wales.
EM duncanpritchard@aranhall.com
CR Brosnan J, 2011, RES DEV DISABIL, V32, P437, DOI 10.1016/j.ridd.2010.12.023
Chowdhury M, 2011, RES DEV DISABIL, V32, P383, DOI 10.1016/j.ridd.2010.11.015
COCCARO EF, 1989, ARCH GEN PSYCHIAT, V46, P587
Cooper SA, 1997, J APPL RES INTELLECT, V10, P303
Deb S, 2001, J INTELL DISABIL RES, V45, P506
Donley M, 2012, BRIT J LEARN DISABIL, V40, P286, DOI 10.1111/j.1468-3156.2011.00707.x
Fisher WW, 1996, AM J MENT RETARD, V101, P15
Hagopian LP, 2002, BEHAV THER, V33, P65, DOI 10.1016/S0005-7894(02)80006-5
HARRIS P, 1993, J INTELL DISABIL RES, V37, P221
HILL BK, 1984, AM J MENT DEF, V88, P380
Johnson J., 2007, INT J BEHAV CONSULTA, V3, P512
Kazdin A. E., 2010, SINGLE CASE RES DESI
Lindsay WR, 1999, MENT RETARD, V37, P201, DOI 10.1352/0047-6765(1999)037<0201:TOASOW>2.0.CO;2
Mace FC, 2011, J APPL BEHAV ANAL, V44, P83, DOI 10.1901/jaba.2011.44-83
MACE FC, 1986, APPL RES MENT RETARD, V7, P203
MacGillivray J. A., 2006, J APPL RES INTELLECT, V19, P163
Pritchard D., 2011, EUR J BEHAV ANAL, V12, P395
Pritchard D., 2011, BR J LEARN DISABIL, V40, P302
Royal Pharmaceutical Society, 2011, BRIT NATL FORMULARY
Sams K, 2006, J APPL RES INTELLECT, V19, P25, DOI 10.1111/j.1468-3148.2006.00303.x
SIGAFOOS J, 1994, J INTELL DISABIL RES, V38, P369
Singh NN, 1996, J INTELL DISABIL RES, V40, P1, DOI 10.1111/j.1365-2788.1996.tb00596.x
Smith S, 1996, BRIT J PSYCHIAT, V169, P219, DOI 10.1192/bjp.169.2.219
Sturmey P, 2006, J APPL RES INTELLECT, V19, P109, DOI 10.1111/j.1468-3148.2006.00301.x
Totsika V, 2008, INT REV RES MENT RET, V35, P205, DOI 10.1016/S0074-7750(07)35006-4
Watson T. S., 2003, CONDUCTING SCH BASED
WHO, 1993, ICD 10 CLASS MENT BE
Willner P, 2006, J APPL RES INTELLECT, V19, P5, DOI 10.1111/j.1468-3148.2005.00280.x
NR 28
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1354-4187
EI 1468-3156
J9 BRIT J LEARN DISABIL
JI Brit. J. Learn. Disabil.
PD JUN
PY 2014
VL 42
IS 2
BP 162
EP 167
DI 10.1111/bld.12019
PG 6
WC Education, Special
SC Education & Educational Research
GA AF9AS
UT WOS:000335007900009
ER
PT J
AU Li, XJ
Sjostedt, C
Sundquist, K
Zoller, B
Sundquist, J
AF Li, Xinjun
Sjostedt, Cecilia
Sundquist, Kristina
Zoller, Bengt
Sundquist, Jan
TI Neighborhood deprivation and childhood autism: A nationwide study from
Sweden
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Childhood autism; Incidence; Multilevel modeling; Neighborhood-level
deprivation; Sociodemographic factors
ID CORONARY-HEART-DISEASE; SPECTRUM DISORDERS; MULTILEVEL ANALYSIS;
RISK-FACTORS; SOCIOECONOMIC-STATUS; DEVELOPMENTAL-DISABILITIES;
SOCIAL-PARTICIPATION; VIOLENT CRIME; HEALTH; COMMUNITY
AB Objective: To examine whether there is an association between neighborhood deprivation and childhood autism, after accounting for family- and individual-level sociodemographic characteristics.
Methods: An open cohort of all children aged 2-11 years was followed between January 1, 2000 and December 31, 2010. Childhood residential locations were geocoded and classified according to neighborhood deprivation (an index of low education, low income, unemployment, and receipt of welfare assistance). Data were analyzed by multilevel logistic regression, with family- and individual-level characteristics at the first level and level of neighborhood deprivation at the second level.
Results: During the study period, among a total of 643,456 children, 1699 (0.3%) were diagnosed with childhood autism. Age-standardized cumulative incidence, defined as first registration for childhood autism during the study period, increased with increasing level of neighborhood deprivation. In the study population, 22 per 1000 and 3.6 per 1000 children in the least and most deprived neighborhoods, respectively, were diagnosed with childhood autism. Incidence of childhood autism increased with increasing neighborhood-level deprivation across all family and individual-level sociodemographic categories. The odds ratio (OR) for childhood autism for those living in high-deprivation neighborhoods versus those living in low-deprivation neighborhoods was 1.59 (95% confidence interval = 1.35-1.88). High neighborhood deprivation remained significantly associated with odds of childhood autism after adjustment for family- and individual-level sociodemographic characteristics (OR = 1.28, 95% confidence. interval = 1.07-1.53, P = 0.007).
Conclusions: This study is the largest so far on potential neighborhood influences on childhood autism. Our results show that neighborhood deprivation is associated with childhood autism, independently of family- and individual-level sociodemographic characteristics. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Li, Xinjun; Sjostedt, Cecilia; Sundquist, Kristina; Zoller, Bengt; Sundquist, Jan] Lund Univ Reg Skane, Ctr Primary Hlth Care Res, Lund, Sweden.
[Sundquist, Kristina; Sundquist, Jan] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA.
RP Li, XJ (reprint author), Skane Univ Hosp, CRC, Ctr Primary Hlth Care Res, Bldg 28,Floor 11,Jan Waldenstroms Gata 35, S-20502 Malmo, Sweden.
EM xinjun.li@med.lu.se
FU National Institute of Drug Abuse [R01 DA030005]; Region Skane; Swedish
Research Council
FX This work was supported by the National Institute of Drug Abuse (R01
DA030005), ALF funding from Region Skane awarded to Jan and Kristina
Sundquist, and grants from the Swedish Research Council (awarded to Jan
Sundquist and Kristina Sundquist). The registers used in the present
study are maintained by Statistics Sweden and the National Board of
Health and Welfare.
CR Bhasin TK, 2007, J AUTISM DEV DISORD, V37, P667, DOI 10.1007/s10803-006-0194-y
BROSSCHOT JF, 1994, PSYCHOSOM MED, V56, P216
Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
Centre for Epidemiology, 2000, VAL DIAGN SWED INC R
Cubbin C, 2006, SCAND J PUBLIC HEALT, V34, P228, DOI 10.1080/14034940500327935
Daniel M, 2008, HEALTH PLACE, V14, P117, DOI 10.1016/j.healthplace.2007.05.003
Doornbos MM, 2013, ARCH PSYCHIAT NURS, V27, P278, DOI 10.1016/j.apnu.2013.09.001
Emerson E, 2012, J EPIDEMIOL COMMUN H, V66, P218, DOI 10.1136/jech.2010.111773
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hock R, 2012, DISABIL HEALTH J, V5, P298, DOI 10.1016/j.dhjo.2012.06.002
Idring S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041280
Ivert AK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081127
Johnell K, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-52
Johnell K, 2006, SOC SCI MED, V62, P1205, DOI 10.1016/j.socscimed.2005.07.008
Kakooza-Mwesige A, 2013, ADAPTATION 10 QUESTI
Kalkbrenner AE, 2012, ENVIRON HEALTH PERSP, V120, P1042, DOI 10.1289/ehp.1104556
Kawachi I, 1999, SOC SCI MED, V48, P719, DOI 10.1016/S0277-9536(98)00400-6
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P926, DOI DOI 10.1093/AJE/KWI123
Lauritsen MB, 2010, J AUTISM DEV DISORD, V40, P139, DOI 10.1007/s10803-009-0818-0
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lochner K, 2001, AM J PUBLIC HEALTH, V91, P385, DOI 10.2105/AJPH.91.3.385
Lofors J, 2007, SOC SCI MED, V64, P21, DOI 10.1016/j.socscimed.2006.08.024
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
Ludvigsson JF, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-450
Magnusson C, 2012, BRIT J PSYCHIAT, V201, P109, DOI 10.1192/bjp.bp.111.095125
McEwen BS, 1997, BRAIN RES REV, V23, P79, DOI 10.1016/S0165-0173(96)00012-4
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
Odgers CL, 2012, DEV PSYCHOPATHOL, V24, P705, DOI 10.1017/S0954579412000326
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Pettygrove S, 2013, J AUTISM DEV DISORD, V43, P1867, DOI 10.1007/s10803-012-1732-4
Rai D, 2012, J AM ACAD CHILD PSY, V51, P467, DOI 10.1016/j.jaac.2012.02.012
Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
Sampson RJ, 1997, SCIENCE, V277, P918, DOI 10.1126/science.277.5328.918
Schempf A, 2009, SOC SCI MED, V68, P100, DOI 10.1016/j.socscimed.2008.10.006
Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
Sundquist J, 1999, INT J EPIDEMIOL, V28, P841, DOI 10.1093/ije/28.5.841
Sundquist J, 2006, SOC SCI MED, V62, P954, DOI 10.1016/j.socscimed.2005.06.049
Sundquist K, 2007, HEALTH PLACE, V13, P324, DOI 10.1016/j.healthplace.2006.02.002
Sundquist K, 2006, SOC SCI MED, V62, P2061, DOI 10.1016/j.socscimed.2005.08.051
Thomas P, 2012, AUTISM, V16, P201, DOI 10.1177/1362361311413397
vanDoorslaer E, 1997, J HEALTH ECON, V16, P93, DOI 10.1016/S0167-6296(96)00532-2
Winkleby M, 2007, AM J PREV MED, V32, P97, DOI 10.1016/j.amepre.2006.10.002
NR 43
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUN
PY 2014
VL 53
BP 187
EP 192
DI 10.1016/j.jpsychires.2014.02.011
PG 6
WC Psychiatry
SC Psychiatry
GA AG0KK
UT WOS:000335104200027
PM 24613033
ER
PT J
AU Lamb, JC
Boffetta, P
Foster, WG
Goodman, JE
Hentz, KL
Rhomberg, LR
Staveley, J
Swaen, G
Van Der Kraak, G
Williams, AL
AF Lamb, James C.
Boffetta, Paolo
Foster, Warren G.
Goodman, Julie E.
Hentz, Karyn L.
Rhomberg, Lorenz R.
Staveley, Jane
Swaen, Gerard
Van Der Kraak, Glen
Williams, Amy L.
TI Critical comments on the WHO-UNEP State of the Science of Endocrine
Disrupting Chemicals-2012
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Endocrine-disrupting chemicals (EDCs); Weight of evidence; Causation;
State of the science; Disease trends; Low-dose effects; Non-monotonic
dose response (NMDR)
ID AUTISM SPECTRUM DISORDERS; SPRAGUE-DAWLEY RATS; DIETARY BISPHENOL-A;
NONMONOTONIC DOSE-RESPONSES; SERUM THYROXINE LEVEL; PROSTATE-CANCER
RISK; FROGS RANA-PIPIENS; DIBENZO-P-DIOXINS; SEMEN QUALITY;
POLYCHLORINATED-BIPHENYLS
AB Early in 2013, the World Health Organization (WHO) released a 2012 update to the 2002 State of the Science of Endocrine Disrupting Chemicals. Several significant concerns have been identified that raise questions about conclusions reached in this report regarding endocrine disruption. First, the report is not a stateof-the-science review and does not follow the 2002 WHO recommended weight-of-evidence approach. Second, endocrine disruption is often presumed to occur based on exposure or a potential mechanism despite a lack of evidence to show that chemicals are causally established as endocrine disruptors. Additionally, causation is often inferred by the presentation of a series of unrelated facts, which collectively do not demonstrate causation. Third, trends in disease incidence or prevalence are discussed without regard to known causes or risk factors; endocrine disruption is implicated as the reason for such trends in the absence of evidence. Fourth, dose and potency are ignored for most chemicals discussed. Finally, controversial topics (i.e., low dose effects, non-monotonic dose response) are presented in a one-sided manner and these topics are important to understanding endocrine disruption. Overall, the 2012 report does not provide a balanced perspective, nor does it accurately reflect the state of the science on endocrine disruption. (C) 2014 The Authors. Published by Elsevier Inc.
C1 [Lamb, James C.; Hentz, Karyn L.; Staveley, Jane; Williams, Amy L.] Exponent, Alexandria, VA 22314 USA.
[Boffetta, Paolo] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
[Boffetta, Paolo] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA.
[Foster, Warren G.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8S 4K1, Canada.
[Goodman, Julie E.; Rhomberg, Lorenz R.] Gradient, Cambridge, MA 02138 USA.
[Swaen, Gerard] Lenz, Exponent, Harrogate HG2 8RE, England.
[Van Der Kraak, Glen] Univ Guelph, Dept Integrat Biol, Guelph, ON N1G 2W1, Canada.
RP Lamb, JC (reprint author), Exponent, 1800 Diagonal Rd,Suite 500, Alexandria, VA 22314 USA.
EM jlamb@exponent.com; paolo.boffetta@gmail.com; foster@mcmaster.ca;
jgoodman@gradientcorp.com; khentz@exponent.com;
lrhomberg@gradientcorp.com; jstaveley@exponent.com; gswaen@exponent.com;
gvanderk@uoguelph.ca; awilliams@exponent.com
CR Ahmed OM, 2008, INT J DEV NEUROSCI, V26, P147, DOI 10.1016/j.ijdevneu.2007.09.011
Alavanja MCR, 2003, AM J EPIDEMIOL, V157, P800, DOI 10.1093/aje/kwg040
Aronson KJ, 2010, J EXPO SCI ENV EPID, V20, P434, DOI 10.1038/jes.2009.33
Auger J, 1997, HUM REPROD, V12, P740, DOI 10.1093/humrep/12.4.740
AUGER J, 1995, NEW ENGL J MED, V332, P281, DOI 10.1056/NEJM199502023320501
Axelsson J, 2011, HUM REPROD, V26, P1012, DOI 10.1093/humrep/der045
BASTOMSK.CH, 1974, ENDOCRINOLOGY, V95, P1150
Benbrahim-Tallaa L, 2008, ENVIRON HEALTH PERSP, V116, P158, DOI 10.1289/ehp.10423
Bergman A., 2012, STATE SCI ENDOCRINE
Bianco AC, 2006, J CLIN INVEST, V116, P2571, DOI 10.1172/JCI29812
Bonde JP, 2011, EPIDEMIOLOGY, V22, P617, DOI 10.1097/EDE.0b013e318223442c
Borgert CJ, 2013, REGUL TOXICOL PHARM, V67, P83, DOI 10.1016/j.yrtph.2013.06.007
Braun JM, 2009, ENVIRON HEALTH PERSP, V117, P1945, DOI 10.1289/ehp.0900979
Bruner-Tran KL, 1999, GYNECOL OBSTET INVES, V48, P45, DOI 10.1159/000052868
BRYAN GW, 1968, J MAR BIOL ASSOC UK, V49, P1067
Cakmak H, 2010, SEMIN REPROD MED, V28, P69, DOI 10.1055/s-0029-1242996
CARLSEN E, 1992, BRIT MED J, V305, P609
Cerna M, 2012, INT J HYG ENVIR HEAL, V215, P109, DOI 10.1016/j.ijheh.2011.09.007
Clark LS, 2006, J COMP PATHOL, V135, P208, DOI 10.1016/j.jcpa.2006.07.005
Conrad JW, 2011, ENVIRON HEALTH PERSP, V119, P757, DOI 10.1289/ehp.1002737
Conrad JW, 2011, ENVIRON HEALTH PERSP, V119, pA508, DOI 10.1289/eph.1104385R
Costello MF, 2002, J ASSIST REPROD GEN, V19, P284, DOI 10.1023/A:1015729314081
*DAN CTR END DISR, 2013, MST62100050 DTU DAN
DIETRICH R, 2013, TOXICOL IN VITRO
Duchan E, 2012, PEDIATR CLIN N AM, V59, P27, DOI 10.1016/j.pcl.2011.10.003
Du Preez LH, 2009, AQUAT TOXICOL, V95, P10, DOI 10.1016/j.aquatox.2009.07.018
*EFSA, 2010, EFSA J, V8, P1932
EFSA, 2013, EFSA J, V11, P3132
EFSA (European Food Safety Authority), 2013, EFSA J
Elia Jlenia, 2012, Arch Ital Urol Androl, V84, P26
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Ferriby LL, 2007, J EXPO SCI ENV EPID, V17, P358, DOI 10.1038/sj.jes.7500498
Fisch H, 2013, ASIAN J ANDROL, V15, P169, DOI 10.1038/aja.2012.143
Fisch H, 2010, J PEDIATR UROL, V6, P37, DOI 10.1016/j.jpurol.2009.05.005
Fombonne E, 2009, MCGILL J MED, V12, P99
Gaido KW, 1997, TOXICOL APPL PHARM, V143, P205, DOI 10.1006/taap.1996.8069
Gentile I, 2013, MED HYPOTHESES, V81, P26, DOI 10.1016/j.mehy.2013.04.002
Gibbs PE, 1999, J MAR BIOL ASSOC UK, V79, P103, DOI 10.1017/S0025315498000113
Glass AG, 2007, J NATL CANCER I, V99, P1152, DOI 10.1093/jnci/djm059
GOLDEY ES, 1995, TOXICOL APPL PHARM, V135, P77, DOI 10.1006/taap.1995.1210
Goodman J, 2009, CRIT REV TOXICOL, V39, P1, DOI 10.3109/10408440903279946
Goodman JE, 2006, CRIT REV TOXICOL, V36, P387, DOI 10.1080/10408440600758317
Goodman JE, 2010, REGUL TOXICOL PHARM, V58, P308, DOI 10.1016/j.yrtph.2010.07.002
*GRADE, 2011, FREQ ASK QUEST
Guinchat V, 2012, ACTA OBSTET GYN SCAN, V91, P287, DOI 10.1111/j.1600-0412.2011.01325.x
Guo SW, 2009, MOL HUM REPROD, V15, P587, DOI 10.1093/molehr/gap064
HAMMOUD AO, 2008, FERTIL STERIL, V90, P2221
Hardell L, 2006, J OCCUP ENVIRON MED, V48, P700, DOI 10.1097/01.jom.0000205989.46603.43
Harvey PW, 2010, J APPL TOXICOL, V30, P617, DOI 10.1002/jat.1569
Hayes T, 2003, ENVIRON HEALTH PERSP, V111, P568, DOI 10.1289/ehp.5932
*HELCOM, 2012, BALT SEA ENV FACT SH
Hengstler JG, 2011, CRIT REV TOXICOL, V41, P263, DOI 10.3109/10408444.2011.558487
Henny CJ, 2010, J TOXICOL ENV HEAL B, V13, P579, DOI 10.1080/10937404.2010.538658
HILL AB, 1965, P ROY SOC MED, V58, P295
Howdeshell KL, 2002, ENVIRON HEALTH PERSP, V110, P337
*IARC, 2004, IARC MON EV CARC RIS, V84, P41
IOM (Institute of Medicine), 2012, BREAST CANC ENV LIF
*IPCS, 2004, 1 IPCS WHO
Itoh H, 2009, SCI TOTAL ENVIRON, V408, P37, DOI 10.1016/j.scitotenv.2009.09.012
Jorgensen N, 2011, INT J ANDROL, V34, pE37, DOI 10.1111/j.1365-2605.2010.01133.x
Jorgensen N, 2012, BMJ OPEN, V2
Jorgensen N, 2001, HUM REPROD, V16, P1012, DOI 10.1093/humrep/16.5.1012
Jorundsdottir K, 2005, MAR POLLUT BULL, V51, P744, DOI 10.1016/j.marpolbul.2005.04.012
Kabbarah O, 2005, INT J CANCER, V115, P666, DOI 10.1002/ijc.20918
Kato Y, 2010, DRUG METAB DISPOS, V38, P697, DOI 10.1124/dmd.109.031153
Kato Y, 2004, TOXICOL SCI, V81, P309, DOI 10.1093/toxsci/kfh225
Keller DA, 2012, TOXICOL SCI, V126, P291, DOI 10.1093/toxsci/kfr350
Kinast K, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00072
Klimisch HJ, 1997, REGUL TOXICOL PHARM, V25, P1, DOI 10.1006/rtph.1996.1076
Kloas W, 2009, TOXICOL SCI, V107, P376, DOI 10.1093/toxsci/kfn232
Kollara A, 2006, BIOCHEM BIOPH RES CO, V346, P526, DOI 10.1016/j.bbrc.2006.05.148
Koutros S, 2010, J OCCUP ENVIRON MED, V52, P1098, DOI 10.1097/JOM.0b013e3181f72b7c
Kripke Clarissa, 2005, Am Fam Physician, V72, P1224
KUIKEN T, 1993, MAR POLLUT B, V26, P400
Lair S, 1997, J WILDLIFE DIS, V33, P430
Leclere B, 2013, CANCER EPIDEMIOL, V37, P544, DOI 10.1016/j.canep.2013.05.001
Lind PM, 2003, AMBIO, V32, P385, DOI 10.1639/0044-7447(2003)032[0385:BMDIMB]2.0.CO;2
Marimuthu P, 2003, ASIAN J ANDROL, V5, P221
Martin L, 2010, TOXICOL SCI, V117, P36, DOI 10.1093/toxsci/kfq187
Mayes BA, 1998, TOXICOL SCI, V41, P62
McDaniel TV, 2008, AQUAT TOXICOL, V88, P230, DOI 10.1016/j.aquatox.2008.05.002
Morton B, 2009, MAR POLLUT BULL, V58, P1530, DOI 10.1016/j.marpolbul.2009.05.012
Murphy MB, 2006, AQUAT TOXICOL, V76, P230, DOI 10.1016/j.aquatox.2005.09.010
Nakamura Y, 2000, J AOAC INT, V83, P635
Nakatani T, 2011, ARCH ENVIRON CON TOX, V60, P543, DOI 10.1007/s00244-010-9553-y
*NCI, 2013, PROST CANC PREV PDQ
NELSON CMK, 1974, FERTIL STERIL, V25, P503
Nilsson R, 2000, TOXICOL PATHOL, V28, P420, DOI 10.1177/019262330002800311
NOHYNEK GJ, 2013, TOXICOL LETT
Nost TH, 2013, ENVIRON HEALTH PERSP, V121, P1292, DOI 10.1289/ehp.1206317
NRC, 2005, HLTH IMPL PERCHL ING
NTP, 2006, NATL TOXICOL PROGRAM, P4
NTP, 2010, NATL TOXICOL PROGRAM, P1
*OECD, 2005, MAN INV HPV CHEM
Pal PC, 2006, ANDROLOGIA, V38, P20, DOI 10.1111/j.1439-0272.2006.00685.x
Rhomberg LR, 2012, REGUL TOXICOL PHARM, V64, P130, DOI 10.1016/j.yrtph.2012.06.015
Rhomberg LR, 2012, CRIT REV TOXICOL, V42, P465, DOI 10.3109/10408444.2012.690367
Rice Catherine, 2007, Morbidity and Mortality Weekly Report, V56, P1
RICE CE, 2012, PUBLIC HLTH REV, V34, P1
Rier SE, 2001, TOXICOL SCI, V59, P147, DOI 10.1093/toxsci/59.1.147
Ritchie JM, 2003, J OCCUP ENVIRON MED, V45, P692, DOI 10.1097/01.jom.0000071510.96740.0b
ROBERTSON A, 1991, J MAR BIOL ASSOC UK, V71, P569
Rolland M, 2013, HUM REPROD, V28, P462, DOI 10.1093/humrep/des415
Sawada N, 2010, ENVIRON HEALTH PERSP, V118, P659, DOI 10.1289/ehp.0901214
Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
Schuhmacher-Wolz U, 2009, CRIT REV TOXICOL, V39, P271, DOI 10.1080/10408440802291505
Séradour B, 2009, Bull Cancer, V96, pE1, DOI 10.1684/bdc.2009.0869
Sharpe RM, 2010, PHILOS T R SOC B, V365, P1697, DOI 10.1098/rstb.2009.0206
Sharpe RM, 2003, INT J ANDROL, V26, P2, DOI 10.1046/j.1365-2605.2003.00367.x
Sirot V, 2012, CHEMOSPHERE, V88, P492, DOI 10.1016/j.chemosphere.2012.03.004
Skelly DK, 2010, ECOHEALTH, V7, P374, DOI 10.1007/s10393-010-0348-4
Smith EE, 2005, AFR J HERPETOL, V54, P69
Soto AM, 1995, ONCOL RES, V7, P545
Spolyarich N, 2011, ENVIRON MONIT ASSESS, V173, P397, DOI 10.1007/s10661-010-1395-6
Stump DG, 2010, TOXICOL SCI, V115, P167, DOI 10.1093/toxsci/kfq025
Swan SH, 1997, ENVIRON HEALTH PERSP, V105, P1228
TEEGUARDEN JG, 2013, FOOD CHEM TOXICOL
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Tinwell H, 2013, REGUL TOXICOL PHARM, V66, P184, DOI 10.1016/j.yrtph.2013.04.002
Titley-O'Neal CP, 2011, J ENVIRON MONITOR, V13, P2360, DOI 10.1039/c1em10011d
Tyl RW, 2008, TOXICOL SCI, V104, P362, DOI 10.1093/toxsci/kfn084
Tyl RW, 2002, TOXICOL SCI, V68, P121, DOI 10.1093/toxsci/68.1.121
*USEPA, 2014, VOC CAT LIST DET INT
USEPA United States Environmental Protection Agency, 2013, STAT SCI EV NONM DOS
*USFDA, 2009, FDA2010N01000001
Vandenberg LN, 2012, ENDOCR REV, V33, P378, DOI 10.1210/er.2011-1050
Van Maele-Fabry G, 2004, INT ARCH OCC ENV HEA, V77, P559, DOI 10.1007/s00420-004-0548-8
van Maele-Fabry G, 2006, CANCER CAUSE CONTROL, V17, P353, DOI 10.1007/s10552-005-0443-y
Verhaegen Y, 2012, CHEMOSPHERE, V86, P979, DOI 10.1016/j.chemosphere.2011.11.028
Wakai K, 1999, NUTR CANCER, V33, P139, DOI 10.1207/S15327914NC330204
WEEDONFEKJAER H, 2012, BMJ-BRIT MED J, V30, pE299
*WHO, 2002, GLOBAL ASSESSMENT ST
Wilhelm M, 2007, INT J HYG ENVIR HEAL, V210, P307, DOI 10.1016/j.ijheh.2007.01.039
WING L, 1976, PSYCHOL MED, V6, P89
Wittassek M, 2007, INT J HYG ENVIR HEAL, V210, P319, DOI 10.1016/j.ijheh.2007.01.037
Xu XH, 2010, ENVIRON HEALTH PERSP, V118, P60, DOI 10.1289/ehp.0900919
Yolton K, 2011, NEUROTOXICOL TERATOL, V33, P558, DOI 10.1016/j.ntt.2011.08.003
Younglai EV, 1998, FERTIL STERIL, V70, P76, DOI 10.1016/S0015-0282(98)00118-6
Zoeller RT, 2000, ENDOCRINOLOGY, V141, P181, DOI 10.1210/en.141.1.181
NR 139
TC 3
Z9 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD JUN
PY 2014
VL 69
IS 1
BP 22
EP 40
DI 10.1016/j.yrtph.2014.02.002
PG 19
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA AG0SL
UT WOS:000335125800003
PM 24530840
ER
PT J
AU Tincani, M
Cucchiarra, MB
Thurman, SK
Snyder, MR
McCarthy, CM
AF Tincani, Matt
Cucchiarra, Maia Bloomfield
Thurman, S. Kenneth
Snyder, Mark R.
McCarthy, Catherine M.
TI Evaluating NRC's Recommendations for Educating Children with Autism a
Decade Later
SO CHILD & YOUTH CARE FORUM
LA English
DT Article
DE Autism spectrum disorder; Autism; National Research Council; Policy;
Parent advocacy
ID SPECTRUM DISORDERS; SCHOOLS; PARENTS
AB Over a decade ago, the National Research Council (NRC) published the influential book, Educating Children with Autism.
To survey parents and state-level special education administrators to evaluate how NRC's recommendations, as published in Educating Children with Autism, have impacted educational practices for children with autism in the US.
149 parents of children with autism and 35 state-level special education administrators from 35 states were surveyed on the degree to which they agreed with NRC's recommendations and the degree to which they believed NRC's recommendations have been implemented.
Parents and administrators agreed with most NRC recommendations; however, disagreements between parents and administrators were evident regarding labeling of students with autism, intensity of services, and training of staff. Conversely, parents and administrators concurred that the recommendations had been poorly to modestly implemented, overall. Lowest levels of implementation were found for training of qualified staff, research-based curricula, and mental health supports for families. Qualitative analysis of parents' comments highlighted that vigorous advocacy was necessary for their children to receive appropriate services consistent with NRC's recommendations.
Over a decade following publication of Educating Children with Autism, most of NRC's recommendations have not been fully implemented. Policy makers should focus particular attention on improving professional training, disseminating research-based practices, and providing mental health supports for families.
C1 [Tincani, Matt; Thurman, S. Kenneth; Snyder, Mark R.; McCarthy, Catherine M.] Temple Univ, Dept Psychol Org & Leadership Studies, Philadelphia, PA 19122 USA.
[Cucchiarra, Maia Bloomfield] Temple Univ, Dept Teaching & Learning, Philadelphia, PA 19122 USA.
RP Thurman, SK (reprint author), Temple Univ, Dept Psychol Org & Leadership Studies, Ritter Annex 283 1301 CB Moore Ave, Philadelphia, PA 19122 USA.
EM sthurman@temple.edu
CR Burns MK, 2009, J SPEC EDUC, V43, P3, DOI 10.1177/0022466908315563
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Chasson G. S., 2007, J CHILD FAM STUD, V16, P401, DOI DOI 10.1007/S10826-006-9094-1
Dennis BW, 2008, PORTAL-LIBR ACAD, V8, P423
Eldevik S, 2010, AJIDD-AM J INTELLECT, V115, P381, DOI 10.1352/1944-7558-115.5.381
Filipek PA, 2000, NEUROLOGY, V55, P468
Glaser B., 1992, BASICS GROUNDED THEO
Granpeesheh D, 2009, RES AUTISM SPECT DIS, V3, P1014, DOI 10.1016/j.rasd.2009.06.007
Henderson K, 2011, J DISABIL POLICY STU, V22, P106, DOI 10.1177/1044207310396210
Horvat EM, 2003, AM EDUC RES J, V40, P319, DOI 10.3102/00028312040002319
Jacobson J, 1998, BEHAV INTERVENT, V13, P201, DOI DOI 10.1002/(SICI)1099-078X
Kansas State Department of Education, 2009, GUID ED STUD AUT SPE
Lareau Annette, 2000, HOME ADVANTAGE SOCIA
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Makrygianni MK, 2010, RES AUTISM SPECT DIS, V4, P577, DOI 10.1016/j.rasd.2010.01.014
Matson J. L., 2010, RES AUTISM SPECT DIS, V5, P418
Meadan H, 2010, EXCEPT CHILDREN, V77, P7
Morrier M. J., 2011, TEACHER ED SPECIAL E, V34, P119, DOI DOI 10.1177/0888406410376660
National Commission on Teaching and America's Future, 2003, NO DREAM DEN PLEDG A
National Research Council, 2001, ED CHILDR AUT
North Carolina Department of Public Instruction, 2011, EV BAS PRACT ED CHIL
Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
Poncheri RM, 2008, ORGAN RES METHODS, V11, P614, DOI 10.1177/1094428106295504
Reichow B, 2009, J AUTISM DEV DISORD, V39, P23, DOI 10.1007/s10803-008-0596-0
Scheuermann B., 2003, FOCUS AUTISM OTHER D, V18, P197, DOI DOI 10.1177/10883576030180030801
Schwartz H, 2008, LANG SPEECH HEAR SER, V39, P66, DOI 10.1044/0161-1461(2008/007)
Singh J, 2009, J AUTISM DEV DISORD, V39, P788, DOI 10.1007/s10803-008-0685-0
Solomon R, 2007, AUTISM, V11, P205, DOI 10.1177/1362361307076842
Spence Sarah J, 2004, Semin Pediatr Neurol, V11, P186, DOI 10.1016/j.spen.2004.07.002
Tincani M, 2007, INTERV SCH CLIN, V43, P47
Twoy R, 2007, J AM ACAD NURSE PRAC, V19, P251, DOI 10.1111/j.1745-7599.2007.00222.x
United States Department of Education, 2006, TEST LEAD CHART FUT
USEEM EL, 1992, SOCIOL EDUC, V65, P263, DOI 10.2307/2112770
Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
Wise MD, 2010, J DEV BEHAV PEDIATR, V31, P469, DOI 10.1097/DBP.0b013e3181e56db2
Yell ML, 2000, J SPEC EDUC, V33, P205, DOI 10.1177/002246690003300403
Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
NR 38
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1053-1890
EI 1573-3319
J9 CHILD YOUTH CARE FOR
JI Child Youth Care Forum
PD JUN
PY 2014
VL 43
IS 3
BP 315
EP 337
DI 10.1007/s10566-013-9240-z
PG 23
WC Psychology, Developmental
SC Psychology
GA AF1UX
UT WOS:000334500500003
ER
PT J
AU Makinen, L
Loukusa, S
Laukkanen, P
Leinonen, E
Kunnari, S
AF Makinen, Leena
Loukusa, Soile
Laukkanen, Paivi
Leinonen, Eeva
Kunnari, Sari
TI Linguistic and pragmatic aspects of narration in Finnish typically
developing children and children with specific language impairment
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE Comprehension; mental state terms; narrative; referencing; specific
language impairment
ID COMPREHENSION; SKILLS; ABILITY; AUTISM; RECALL; MEMORY
AB This study investigates narratives of Finnish children with specific language impairment (SLI) from linguistic and pragmatic perspectives, in order to get a comprehensive overview of these children's narrative abilities. Nineteen children with SLI (mean age 6; 1 years) and 19 typically developing age-matched children participated in the study. Their picture-elicited narrations were analysed for linguistic productivity and complexity, grammatical and referential accuracy, event content, the use of mental state expressions and narrative comprehension. Children with SLI showed difficulties in every aspect of narration in comparison to their peers. Only one measure of productivity, the number of communication units, did not reach statistical significance. Not only was linguistic structure fragile but also pragmatic aspects of storytelling (referencing, event content, mental state expressions and inferencing) were demanding for children with SLI. Results suggest that pragmatic aspects of narration should be taken into account more often when assessing narrative abilities of children with SLI.
C1 [Makinen, Leena; Loukusa, Soile; Laukkanen, Paivi; Kunnari, Sari] Univ Oulu, Child Language Res Ctr, Fac Humanities, FI-90014 Oulu, Finland.
[Leinonen, Eeva] Univ Wollongong, Dept Psychol, Wollongong, NSW 2500, Australia.
RP Makinen, L (reprint author), Univ Oulu, Child Language Res Ctr, Fac Humanities, POB 1000, FI-90014 Oulu, Finland.
EM leena.makinen@oulu.fi
FU Finnish Brain Foundation; Finnish Cultural Foundation; Oulu University
Scholarship Foundation; University of Oulu Faculty of Humanities;
Academy of Finland
FX The authors report no declarations of interest. This research was
supported by grants from the Finnish Brain Foundation, the Finnish
Cultural Foundation, the Oulu University Scholarship Foundation,
University of Oulu Faculty of Humanities and the Academy of Finland.
CR ASTINGTON JW, 1990, NARRATIVE THOUGHT AND NARRATIVE LANGUAGE, P151
BAMBERG M, 1991, J CHILD LANG, V18, P689
Bishop DVM, 2005, BRIT J DEV PSYCHOL, V23, P25, DOI 10.1348/026151004X20685
Botting N, 2001, J CHILD PSYCHOL PSYC, V42, P1013, DOI 10.1111/1469-7610.00799
Brinton B, 2007, J SPEECH LANG HEAR R, V50, P798, DOI 10.1044/1092-4388(2007/055)
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Colozzo P, 2011, J SPEECH LANG HEAR R, V54, P1609, DOI 10.1044/1092-4388(2011/10-0247)
Dodwell K, 2008, INT J LANG COMM DIS, V43, P201, DOI 10.1080/13682820701366147
Duinmeijer I, 2012, INT J LANG COMM DIS, V47, P542, DOI 10.1111/j.1460-6984.2012.00164.x
Eaton JH, 1999, J CHILD LANG, V26, P699, DOI 10.1017/S0305000999003967
Farrar J. M., 2009, J COMMUN DISORD, V42, P428
Fey ME, 2004, J SPEECH LANG HEAR R, V47, P1301, DOI 10.1044/1092-4388(2004/098)
Finestack LH, 2006, J COMMUN DISORD, V39, P232, DOI 10.1016/j.jcomdis.2005.12.003
German D. J., 2000, TEST WORD FINDING
Hickmann M., 2004, RELATING EVENTS NARR, P281
Hughes D., 1997, GUIDE NARRATIVE LANG
Huttunen K, 2012, CLIN LINGUIST PHONET, V26, P823, DOI 10.3109/02699206.2012.682836
Johnston JR, 2008, TOP LANG DISORD, V28, P93
KINTSCH W, 1978, PSYCHOL REV, V85, P363, DOI 10.1037//0033-295X.85.5.363
Kirk S. A., 1968, ILLINOIS TEST PSYCHO
Korkman M, 2008, NEPSY 2 LASTEN NEURO
Kunnari S, 2011, J CHILD LANG, V38, P999, DOI 10.1017/S0305000910000528
Leonard LB, 2014, APPL PSYCHOLINGUIST, V35, P833, DOI 10.1017/S0142716412000598
Leinonen E, 2003, LINGUISTICS, V41, P407, DOI 10.1515/ling.2003.014
Leonard L. B., 1998, CHILDREN SPECIFIC LA
Liiva CA, 2005, J SPEECH LANG HEAR R, V48, P868, DOI 10.1044/1092-4388(2005/060)
Makinen L., 2013, 1 LANGUAGE, DOI 10.1/77/0142723713511000
McGhee RL, 2007, TOKEN TEST CHILDREN
McWhinney B., 2000, CHILDES PROJECT TOOL
Miller CA, 2001, J COMMUN DISORD, V34, P73, DOI 10.1016/S0021-9924(00)00042-3
Norbury CF, 2002, INT J LANG COMM DIS, V37, P227, DOI 10.1080/13682820210136269
Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
Norbury CF, 2014, J CHILD LANG, V41, P485, DOI 10.1017/S030500091300007X
Pearce WM, 2010, CLIN LINGUIST PHONET, V24, P622, DOI 10.3109/02699201003736403
Reilly J, 2004, BRAIN LANG, V88, P229, DOI 10.1016/S0093-934X(03)00101-9
Ryder N, 2008, INT J LANG COMM DIS, V43, P427, DOI 10.1080/13682820701633207
Sperber D., 1995, RELEVANCE COMMUNICAT
Stothard SE, 1998, J SPEECH LANG HEAR R, V41, P407
Suvanto A., 2012, THESIS U OULU FINLAN
Taylor LJ, 2012, J AUTISM DEV DISORD, V42, P2067, DOI 10.1007/s10803-012-1456-5
To CKS, 2010, J SPEECH LANG HEAR R, V53, P648, DOI 10.1044/1092-4388(2009/08-0039)
Tulviste T., 2004, ONGOING THEMES PSYCH
Vainikka A, 1999, NAT LANG LINGUIST TH, V17, P613, DOI 10.1023/A:1006225032592
vanderLely HKJ, 1997, J CHILD LANG, V24, P221, DOI 10.1017/S0305000996002966
Van Horne AJO, 2011, CLIN LINGUIST PHONET, V25, P881, DOI 10.3109/02699206.2011.582226
Wilcock G., 2006, SKY J LINGUISTICS, V19, P291
NR 46
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9206
EI 1464-5076
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD JUN
PY 2014
VL 28
IS 6
BP 413
EP 427
DI 10.3109/02699206.2013.875592
PG 15
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AF8AX
UT WOS:000334938500003
PM 24446795
ER
PT J
AU Roche, L
Sigafoos, J
Lancioni, GE
O'Reilly, MF
van der Meer, L
Achmadi, D
Green, VA
Kagohara, D
Sutherland, D
Rayner, C
Marschik, PB
AF Roche, Laura
Sigafoos, Jeff
Lancioni, Giulio E.
O'Reilly, Mark F.
van der Meer, Larah
Achmadi, Donna
Green, Vanessa A.
Kagohara, Debora
Sutherland, Dean
Rayner, Christopher
Marschik, Peter B.
TI Comparing Tangible Symbols, Picture Exchange, and a Direct Selection
Response for Enabling Two Boys with Developmental Disabilities to Access
Preferred Stimuli
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Augmentative and alternative communication; Autism spectrum disorders;
Developmental disability; Direct selection; Picture exchange; Tangible
symbols
ID AUTISM SPECTRUM DISORDERS; COMMUNICATION-SYSTEM PECS; MULTIPLE
DISABILITIES; COMPARATIVE EFFICACY; REQUESTING SKILLS; VISUAL
IMPAIRMENT; CHILDREN; MODES
AB We compared how quickly two boys with developmental disabilities learned to use tangible symbols, picture exchange, and a direct selection response to access cartoon videos. Intervention, aimed at teaching the boys to use each option, was evaluated in a multiple-baseline across participants and alternating treatments design. Following intervention, the boys were allowed to choose among the three options. Both participants learned to access six cartoon videos using the three options at comparable rates. Following acquisition, both boys most often chose to use tangible symbols. These findings are consistent with previous studies reporting comparable acquisition rates and a preference among communication options. The present study extends the literature by including a comparison of tangible symbols and a direct selection response. Our results provide additional support for the use of tangible symbols as a communication option for children with developmental disabilities.
C1 [Roche, Laura; Sigafoos, Jeff; van der Meer, Larah; Achmadi, Donna; Green, Vanessa A.; Kagohara, Debora] Victoria Univ Wellington, Sch Educ Psychol, Wellington 6147, New Zealand.
[Lancioni, Giulio E.] Univ Bari, Dept Neurosci & Sense Organs, Bari, Italy.
[O'Reilly, Mark F.] Univ Texas Austin, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
[Sutherland, Dean] Univ Canterbury, Sch Hlth Sci, Coll Educ, Christchurch 1, New Zealand.
[Rayner, Christopher] Univ Tasmania, Sch Educ, Hobart, Tas, Australia.
[Marschik, Peter B.] Med Univ Graz, Inst Physiol, Graz, Austria.
RP Sigafoos, J (reprint author), Victoria Univ Wellington, Sch Educ Psychol, POB 17-310, Wellington 6147, New Zealand.
EM jeff.sigafoos@vuw.ac.nz
CR Ali E, 2011, EDUC TRAIN AUTISM DE, V46, P425
Boesch MC, 2013, RES AUTISM SPECT DIS, V7, P480, DOI 10.1016/j.rasd.2012.12.002
Boesch MC, 2013, AUGMENT ALTERN COMM, V29, P197, DOI 10.3109/07434618.2013.818059
Duker P. C., 2004, ONE TO ONE TRAINING
Flores M, 2012, AUGMENT ALTERN COMM, V28, P74, DOI 10.3109/07434618.2011.644579
Kennedy C, 2005, SINGLE CASE DESIGNS
Lorah ER, 2013, J DEV PHYS DISABIL, V25, P637, DOI 10.1007/s10882-013-9337-1
Lund SK, 2008, J AUTISM DEV DISORD, V38, P719, DOI 10.1007/s10803-007-0439-4
Wilkins J, 2007, INT REV RES MENT RET, V34, P321, DOI 10.1016/S0074-7750(07)34010-X
Parker A. T., 2010, AER J RES PRACTICE V, V3, P2
Roche L., 2013, TANGIBLE SYMBO UNPUB
Schlosser R. W., 2002, AUGMENTATIVE ALTERNA, V18, P102, DOI 10.1080/07434610212331281201
Schlosser R. W., 2003, EFFICACY AUGMENTATIV
ROWLAND C, 1989, AAC (Augmentative and Alternative Communication), V5, P226, DOI 10.1080/07434618912331275276
Schweigert P., 2000, AUGMENTATIVE ALTERNA, V16, P61, DOI DOI 10.1080/07434610012331278914
Sigafoos J., 2005, TECHNOLOGY DISABILIT, V17, P143
Son Seung-Hyun, 2006, Pediatr Rehabil, V9, P389, DOI 10.1080/13638490500519984
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Trief E, 2013, J VISUAL IMPAIR BLIN, V107, P180
Trief E, 2007, J VISUAL IMPAIR BLIN, V101, P613
Turnell Ruth, 1994, Australia and New Zealand Journal of Developmental Disabilities, V19, P193
van der Meer L., 2013, CLIN CASE STUDIES
van der Meer L, 2013, AUGMENT ALTERN COMM, V29, P222, DOI 10.3109/07434618.2013.815801
van der Meer L, 2012, J DEV PHYS DISABIL, V24, P451, DOI 10.1007/s10882-012-9283-3
van der Meer L, 2012, RES AUTISM SPECT DIS, V6, P1247, DOI 10.1016/j.rasd.2012.04.005
NR 25
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2014
VL 26
IS 3
BP 249
EP 261
DI 10.1007/s10882-013-9361-1
PG 13
WC Rehabilitation
SC Rehabilitation
GA AF4LV
UT WOS:000334685100001
ER
PT J
AU Davis, TN
Fuentes, L
Durand, S
AF Davis, Tonya N.
Fuentes, Lisa
Durand, Shannon
TI Examination of Systematic Durations of Presession Reinforcer Access on
Functional Communication Training
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Functional communication training; Motivating operation; Autism;
Challenging behavior
ID PROBLEM BEHAVIOR; DISABILITIES; OPERATION; ATTENTION; STIMULI
AB In this study, we identified the latency to satiation with an activity that maintained problem behavior for a boy with autism. Next, functional communication training (FCT) was implemented. Prior to FCT sessions, the participant was exposed one of to two conditions of presession exposure to stimuli that served as the reinforcer during subsequent FCT sessions. Latency to satiation was used to systematically identify the two durations of stimulus access: (a) 25 % of the mean latency to satiation and (b) 50 % of the mean latency to satiation. Results indicate that while both durations of presession access to the preferred activity resulted in decreased problem behavior, independent manding during FCT was higher in the shorter duration of presession access. The implications of this research are that the presession exposure to stimuli can be systematically individualized to optimize its effect as a motivating operation.
C1 [Davis, Tonya N.; Fuentes, Lisa; Durand, Shannon] Baylor Univ, Waco, TX 76798 USA.
RP Davis, TN (reprint author), Baylor Univ, Waco, TX 76798 USA.
EM Tonya_Davis@baylor.edu
CR AYLLON T, 1968, J APPL BEHAV ANAL, V1, P13, DOI 10.1901/jaba.1968.1-13
CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
Davis TN, 2009, J DEV PHYS DISABIL, V21, P515, DOI 10.1007/s10882-009-9158-4
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
McComas JJ, 2003, J APPL BEHAV ANAL, V36, P297, DOI 10.1901/jaba.2003.36-297
MICHAEL J, 1982, J EXP ANAL BEHAV, V37, P149, DOI 10.1901/jeab.1982.37-149
O'Reilly M, 2009, J APPL BEHAV ANAL, V42, P773, DOI 10.1901/jaba.2009.42-773
O'Reilly MF, 2008, RES DEV DISABIL, V29, P333, DOI 10.1016/j.ridd.2007.06.004
Rispoli M, 2011, J APPL BEHAV ANAL, V44, P187, DOI 10.1901/jaba.2011.44-187
Roantree CF, 2006, J APPL BEHAV ANAL, V39, P381, DOI 10.1901/jaba.2006.97-05
Skinner B. F., 1957, VERBAL BEHAV
NR 12
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2014
VL 26
IS 3
BP 263
EP 270
DI 10.1007/s10882-013-9360-2
PG 8
WC Rehabilitation
SC Rehabilitation
GA AF4LV
UT WOS:000334685100002
ER
PT J
AU Falcomata, TS
Gainey, S
AF Falcomata, Terry S.
Gainey, Summer
TI An Evaluation of Noncontingent Reinforcement for the Treatment of
Challenging Behavior with Multiple Functions
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism; Challenging behavior; Multiple functions; Noncontingent
reinforcement
ID INTERVENTION; AUTISM
AB The purpose of this study was to evaluate the relative treatment effects of different forms of noncontingent reinforcement (NCR) on challenging behavior with multiple functions. We first conducted a functional analysis of challenging behavior exhibited by a child with autism. The results of the functional analysis suggested that challenging behavior served multiple functions. Next, we conducted a treatment evaluation in which we (a) compared the effects of NCR with attention to NCR with attention and preferred activities in the absence of work activities and (b) compared the effects of NCR with attention and NCR with attention and preferred activities during work activities. The results of the treatment evaluation showed that NCR with attention and preferred activities was more effective at decreasing challenging behavior than NCR with attention both when work was not implemented and during work situations. The current results provide support for the use of noncontingent multiple functional reinforcers to treat multiply-maintained challenging behavior.
C1 [Falcomata, Terry S.; Gainey, Summer] Univ Texas Austin, Austin, TX 78712 USA.
RP Falcomata, TS (reprint author), Univ Texas Austin, Austin, TX 78712 USA.
EM falcomata@austin.utexas.edu
CR Bachmeyer MH, 2009, J APPL BEHAV ANAL, V42, P641, DOI 10.1901/jaba.2009.42-641
Borrero CSW, 2006, J APPL BEHAV ANAL, V39, P375, DOI 10.1901/jaba.2006.170-04
Call NA, 2005, J APPL BEHAV ANAL, V38, P385, DOI 10.1901/jaba.2005.51-04
CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
DAY HM, 1994, J APPL BEHAV ANAL, V27, P279, DOI 10.1901/jaba.1994.27-279
Falcomata T. S., 2012, J DEV PHYS DISABIL, V6, P529
Falcomata TS, 2013, BEHAV MODIF, V37, P723, DOI 10.1177/0145445513500785
Hagopian LP, 2001, J APPL BEHAV ANAL, V34, P229, DOI 10.1901/jaba.2001.34-229
Ingvarsson ET, 2008, J APPL BEHAV ANAL, V41, P435, DOI 10.1901/jaba.2008.41-435
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Kazdin A. E., 1982, SINGLE CASE RES DESI
Love JR, 2009, J AUTISM DEV DISORD, V39, P363, DOI 10.1007/s10803-008-0633-z
Neidert P. L., 2005, EXCEPTIONALITY, V13, P45, DOI 10.1207/s15327035ex1301_6
O'Reilly M, 2010, RES AUTISM SPECT DIS, V4, P1, DOI 10.1016/j.rasd.2009.07.001
Reese R. M., 2003, FOCUS AUTISM OTHER D, V18, P87
Rispoli M, 2013, J DEV PHYS DISABIL, V25, P135, DOI 10.1007/s10882-012-9315-z
Roane HS, 1998, J APPL BEHAV ANAL, V31, P605, DOI 10.1901/jaba.1998.31-605
Sigafoos J, 1996, BEHAV MODIF, V20, P60, DOI 10.1177/01454455960201003
Vollmer TR, 1997, J APPL BEHAV ANAL, V30, P161, DOI 10.1901/jaba.1997.30-161
NR 19
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2014
VL 26
IS 3
BP 317
EP 324
DI 10.1007/s10882-014-9366-4
PG 8
WC Rehabilitation
SC Rehabilitation
GA AF4LV
UT WOS:000334685100006
ER
PT J
AU Schroeder, SR
Richman, DM
Abby, L
Courtemanche, AB
Oyama-Ganiko, R
AF Schroeder, Stephen R.
Richman, David M.
Abby, Layla
Courtemanche, Andrea B.
Oyama-Ganiko, Rosa
TI Functional Analysis Outcomes and Comparison of Direct Observations and
Informant Rating Scales in the Assessment of Severe Behavior Problems of
Infants and Toddlers At-Risk for Developmental Delays
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Functional analysis; Informant ratings; Infants; Toddlers; Developmental
delays
ID INVENTORY-SHORT FORM; INTELLECTUAL DISABILITIES; YOUNG-CHILDREN;
SELF-INJURY; INDIVIDUALS; VALIDITY; RELIABILITY; AUTISM; ADULTS
AB Severe problem behaviors, like aggression, self-injury, and repetitive behaviors, in people with intellectual and developmental disabilities often appear during early development and may persist without early intervention. The frequencies of self-injurious behavior, aggression, tantrums, property destruction and stereotyped behavior among 17 infants and toddlers at risk for developmental delays and severe behavior problems were assessed using two methods: 1) direct observation of responses during 10 s partial interval recording during analogue functional analysis and 2) the Behavior Problem Inventory-01 (BPI-01; Rojahn et al. Journal of Autism and Developmental Disorders, 31, 577-588, 2001), an informant rating scale. Analogue functional analysis results suggested that the most common function for problem behavior was automatic reinforcement, followed by negative reinforcement in the form of escape from demands. Agreement across the two types of measurement systems as to occurrence of the behaviors reported on the BPI-01 and direct observations during analogue functional analyses was greater than 75 % across aggression, self-injury, and stereotyped behavior. Agreement at a more molecular level of the ranking of the most commonly occurring specific behaviors was considerably lower. Results are discussed in terms of future research on identifying conditions that set the occasion for high levels of agreement between indirect and direct measurement systems for severe behavior problems.
C1 [Schroeder, Stephen R.] Univ Kansas, Lawrence, KS 66045 USA.
[Richman, David M.; Abby, Layla] Texas Tech Univ, Lubbock, TX 79409 USA.
[Oyama-Ganiko, Rosa] Ctr Ann Sullivan Peru, Lima, Peru.
[Courtemanche, Andrea B.] Univ Kansas, Med Ctr, Kansas City, MO USA.
RP Schroeder, SR (reprint author), Univ Kansas, Lawrence, KS 66045 USA.
EM srs@ku.edu
CR Barlow D. H., 2008, SINGLE CASE EXPT DES
Bayley N., 2006, MANUAL BAYLEY SCALES, V3rd
Beavers GA, 2013, J APPL BEHAV ANAL, V46, P1, DOI 10.1002/jaba.30
Berkson G, 2001, AM J MENT RETARD, V106, P539, DOI 10.1352/0895-8017(2001)106<0539:EDOSAS>2.0.CO;2
Gonzalez ML, 2009, J APPL RES INTELLECT, V22, P223, DOI 10.1111/j.1468-3148.2008.00429.x
Guilford J. P., 1956, STAT PSYCHOL ED
Hagopian LP, 1997, J APPL BEHAV ANAL, V30, P313, DOI 10.1901/jaba.1997.30-313
Hanley GP, 2003, J APPL BEHAV ANAL, V36, P147, DOI 10.1901/jaba.2003.36-147
IWATA BA, 1982, ANAL INTERVEN DEVEL, V2, P3, DOI 10.1016/0270-4684(82)90003-9
Johnston JM, 2009, STRATEGIES AND TACTICS OF BEHAVIORAL RESEARCH, THIRD EDITION, P1
Kurtz PF, 2012, J MENT HEALTH RES IN, V5, P260, DOI 10.1080/19315864.2011.600809
Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
Mayo-Ortega L, 2012, J MENT HEALTH RES IN, V5, P246, DOI 10.1080/19315864.2011.590626
Morris E K, 1982, Behav Anal, V5, P109
Richman DM, 2005, AM J MENT RETARD, V110, P439, DOI 10.1352/0895-8017(2005)110[439:LAOSPA]2.0.CO;2
Rojahn J, 2010, J APPL RES INTELLECT, V23, P179, DOI 10.1111/j.1468-3148.2009.00519.x
Rojahn J, 2012, J INTELL DISABIL RES, V56, P546, DOI 10.1111/j.1365-2788.2011.01506.x
Rojahn J, 2003, RES DEV DISABIL, V24, P391, DOI 10.1016/S0891-4222(03)00055-6
Rojahn J, 2012, J INTELL DISABIL RES, V56, P527, DOI 10.1111/j.1365-2788.2011.01507.x
Rojahn J, 2001, J AUTISM DEV DISORD, V31, P577, DOI 10.1023/A:1013299028321
Barnard-Brak L, 2013, J PSYCHOPATHOL BEHAV, V35, P564, DOI 10.1007/s10862-013-9356-3
Schopler E., 1988, CHILD AUTISM RATING
Schroeder S. R., 2014, AM J INTELL IN PRESS
Schroeder SR, 2014, J DEV PHYS DISABIL, V26, P237, DOI 10.1007/s10882-013-9359-8
Sturmey P., 1993, J DEV PHYS DISABIL, V5, P327, DOI 10.1007/BF01046389
THOMPSON T, 1986, J EXP ANAL BEHAV, V46, P219, DOI 10.1901/jeab.1986.46-219
Wacker DP, 1998, J DEV BEHAV PEDIATR, V19, P260, DOI 10.1097/00004703-199808000-00004
Wetherby AM, 2002, COMMUNICATION SYMBOL
NR 28
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2014
VL 26
IS 3
BP 325
EP 334
DI 10.1007/s10882-014-9368-2
PG 10
WC Rehabilitation
SC Rehabilitation
GA AF4LV
UT WOS:000334685100007
ER
PT J
AU Lorah, ER
Crouser, J
Gilroy, SP
Tincani, M
Hantula, D
AF Lorah, Elizabeth R.
Crouser, Julie
Gilroy, Shawn P.
Tincani, Matt
Hantula, Donald
TI Within Stimulus Prompting to Teach Symbol Discrimination Using an iPadA
(R) Speech Generating Device
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Mand; Speech-generating device; Voice output communication aid; Autism;
Stimulus discrimination
ID DEVELOPMENTAL-DISABILITIES; ALTERNATIVE COMMUNICATION; CHILDREN; AUTISM;
INDIVIDUALS; PREFERENCES; MODES
AB This study evaluated the effects of within stimulus prompting and prompt fading to teach four preschool children with autism picture symbol discrimination using an iPadA (R) and the Proloqu2Go application as a speech-generating device. Participants were taught to discriminate between a progressively more complex field of picture-symbols depicted on the screen of an iPad with a five-phased training procedure. All participants acquired discrimination between picture-symbols while using the iPad to mand for preferred items in a field of four picture-symbols. The results provide tentative support for a procedure to teach children with autism to discriminate between picture symbols while manding using a handheld speech-generating device.
C1 [Lorah, Elizabeth R.] Univ Arkansas, Fayetteville, AR 72701 USA.
[Crouser, Julie; Gilroy, Shawn P.; Tincani, Matt; Hantula, Donald] Temple Univ, Philadelphia, PA 19122 USA.
RP Lorah, ER (reprint author), Univ Arkansas, Fayetteville, AR 72701 USA.
EM lorah@uark.edu
CR Andermeier K., 2008, RES AUTISM SPECT DIS, V2, P430
Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
Cooper J. O., 2007, APPL BEHAV ANAL
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Gast D. L., 2010, SINGLE SUBJECT RES M
Kagohara DM, 2013, RES DEV DISABIL, V34, P147, DOI 10.1016/j.ridd.2012.07.027
Lindsley OR, 1964, J EDUC, V147, P62
Lorah ER, 2013, J DEV PHYS DISABIL, V25, P637, DOI 10.1007/s10882-013-9337-1
MacDuff G. S., 2001, MAKING DIFFERENCE BE, P37
MirandaLinne FM, 1997, J AUTISM DEV DISORD, V27, P245, DOI 10.1023/A:1025846330262
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
Peeters T, 1999, AUTISM MED ED ASPECT
SCHREIBMAN L, 1975, J APPL BEHAV ANAL, V8, P91, DOI 10.1901/jaba.1975.8-91
Sigafoos J., 2007, AUTISM SPECTRUM DISO, P151
Smith T, 2006, BEHAV INTERVENT, V21, P245, DOI 10.1002/bin.223
Sundberg M. L., 2008, VB MAPP VERBAL BEHAV
van der Meer L, 2011, RES DEV DISABIL, V32, P1422, DOI 10.1016/j.ridd.2011.02.003
van der Meer L, 2012, J DEV PHYS DISABIL, V24, P451, DOI 10.1007/s10882-012-9283-3
van der Meer L, 2012, RES AUTISM SPECT DIS, V6, P1247, DOI 10.1016/j.rasd.2012.04.005
Wetherby A. M., 2005, AUTISM SPECTRUM DISO, P327
NR 20
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2014
VL 26
IS 3
BP 335
EP 346
DI 10.1007/s10882-014-9369-1
PG 12
WC Rehabilitation
SC Rehabilitation
GA AF4LV
UT WOS:000334685100008
ER
PT J
AU Lancioni, GE
Singh, NN
O'Reilly, MF
Sigafoos, J
Boccasini, A
Alberti, G
Lang, R
AF Lancioni, Giulio E.
Singh, Nirbhay N.
O'Reilly, Mark F.
Sigafoos, Jeff
Boccasini, Adele
Alberti, Gloria
Lang, Russell
TI People with Multiple Disabilities Use Basic Reminding Technology to
Engage in Daily Activities at the Appropriate Times
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Technology; Smartphone; Daily activities; Multiple disabilities
ID TRAUMATIC BRAIN-INJURY; MODERATE ALZHEIMERS-DISEASE; PERSONAL DIGITAL
ASSISTANT; MILD COGNITIVE IMPAIRMENT; AUTISM SPECTRUM DISORDERS; PICTURE
ACTIVITY SCHEDULE; DEVELOPMENTAL-DISABILITIES; INTELLECTUAL
DISABILITIES; SOCIAL VALIDATION; INDIVIDUALS
AB We assessed whether three adults with multiple disabilities could use simple reminding technology to carry out daily activities at the appropriate times. The technology consisted of a Galaxy S-3 mini smartphone (by Samsung) with the application of (a) the talking alarm program for providing verbal instructions about the single activities scheduled (for two participants) or (b) the photo alarm program for providing vibration alerting combined with pictorial instructions about the activities (for the third participant). For each participant, the study involved an ABAB sequence, in which A represented baseline phases (without technology) and B intervention phases (with technology). All three participants were successful in using the technology to independently perform the activities scheduled (i.e., between seven and 10 per day) at the appropriate times. The practical implications of the findings and the importance of technology resources in programs for people with multiple disabilities are discussed.
C1 [Lancioni, Giulio E.] Univ Bari, Dept Neurosci & Sense Organs, I-70100 Bari, Italy.
[Singh, Nirbhay N.] Georgia Regents Univ, Med Coll Georgia, Augusta, GA USA.
[O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
[Sigafoos, Jeff] Victoria Univ Wellington, Wellington, New Zealand.
[Boccasini, Adele; Alberti, Gloria] Lega F DOro Res Ctr, Osimo, Italy.
[Lang, Russell] SW Texas State Univ, San Marcos, TX 78666 USA.
RP Lancioni, GE (reprint author), Univ Bari, Dept Neurosci & Sense Organs, Via Quintino Sella 268, I-70100 Bari, Italy.
EM giulio.lancioni@uniba.it; nirbsingh52@aol.com;
markoreilly@austin.utexas.edu; jeff.sigafoos@vuw.ac.nz;
adele.boccasini@alice.it; glorya84@hotmail.com; rl30@txstate.edu
CR Ayres KM, 2013, PSYCHOL SCHOOLS, V50, P259, DOI 10.1002/pits.21673
Barlow D., 2009, SINGLE CASE EXPT DES
Boman IL, 2010, SCAND J OCCUP THER, V17, P140, DOI 10.3109/11038120902875144
Boman I-L, 2010, Disabil Rehabil Assist Technol, V5, P339, DOI 10.3109/17483100903131777
Callahan K, 2008, J AUTISM DEV DISORD, V38, P678, DOI 10.1007/s10803-007-0434-9
Campbell NL, 2012, AM J GERIATR PHARMAC, V10, P165, DOI 10.1016/j.amjopharm.2012.04.004
Cannella-Malone H. I., 2013, J BEHAV ED, V22, P169
Cannella-Malone HI, 2011, J POSIT BEHAV INTERV, V13, P144, DOI 10.1177/1098300710366593
Catania A. C., 2012, LEARNING, V5th
Chan JM, 2013, EDUC TRAIN AUTISM DE, V48, P412
de Joode E, 2010, CLIN REHABIL, V24, P701, DOI 10.1177/0269215510367551
DePompei R, 2008, NEUROREHABILITATION, V23, P487
Dowds MM, 2011, J HEAD TRAUMA REHAB, V26, P339, DOI 10.1097/HTR.0b013e3181f2bf1d
Duttlinger C, 2013, FOCUS AUTISM DEV DIS, V28, P32, DOI 10.1177/1088357612460572
Fish J, 2008, J NEUROL NEUROSUR PS, V79, P930, DOI 10.1136/jnnp.2007.125203
Gentry T, 2008, BRAIN INJURY, V22, P19, DOI 10.1080/02699050701810688
Gentry T., 2010, J VOCATIONAL REHABIL, V32, P101
Gillespie A, 2012, J INT NEUROPSYCH SOC, V18, P1, DOI 10.1017/S1355617711001548
Jumisko E, 2009, J CLIN NURS, V18, P2273, DOI 10.1111/j.1365-2702.2008.02738.x
Kamimura T, 2012, AM J ALZHEIMERS DIS, V27, P238, DOI 10.1177/1533317512450066
KAZDIN AE, 2001, BEHAV MODIFICATION A
Kennedy C, 2005, SINGLE CASE DESIGNS
Lancioni G. E., 2011, CLIN CASE STUDIES, V10, P79, DOI 10.1177/1534650110395380
Lancioni GE, 2014, AUT CHILD PSYCHO, P1, DOI 10.1007/978-1-4899-8029-8
Lancioni GE, 2012, RES DEV DISABIL, V33, P265, DOI 10.1016/j.ridd.2011.09.017
Lancioni GE, 2009, AM J ALZHEIMERS DIS, V24, P246, DOI 10.1177/1533317509332627
Lancioni GE, 2011, RES DEV DISABIL, V32, P2739, DOI 10.1016/j.ridd.2011.05.036
Lancioni GE, 2006, J DEV PHYS DISABIL, V18, P383, DOI 10.1007/s10882-006-9024-6
Lancioni GE, 2000, BEHAV MODIF, V24, P724
Lancioni GE, 2010, RES DEV DISABIL, V31, P1240, DOI 10.1016/j.ridd.2010.07.021
Lancioni GE, 2002, PERCEPT MOTOR SKILL, V94, P1214
Lang R, 2010, DEV NEUROREHABIL, V13, P153, DOI 10.3109/17518421003607597
Lau S., 2012, J VOCATIONAL REHABIL, V37, P75, DOI [10:3233/JVR-2012-0601, DOI 10.3233/JVR-2012-0601]
Lemoncello R, 2011, NEUROPSYCHOL REHABIL, V21, P825, DOI 10.1080/09602011.2011.618661
McDonald A, 2011, NEUROPSYCHOL REHABIL, V21, P784, DOI 10.1080/09602011.2011.598405
McDougall J, 2010, REM SPEC EDUC, V31, P252, DOI 10.1177/0741932509355989
McNaughton D, 2013, AUGMENT ALTERN COMM, V29, P107, DOI 10.3109/07434618.2013.784930
Mechling LC, 2010, EDUC TRAIN AUTISM DE, V45, P422
Palmen A, 2012, DEV NEUROREHABIL, V15, P401, DOI 10.3109/17518423.2012.701240
Perilli V, 2013, RES DEV DISABIL, V34, P1991, DOI 10.1016/j.ridd.2013.03.016
Ripat Jacquie, 2011, Disabil Rehabil Assist Technol, V6, P87, DOI 10.3109/17483107.2010.507859
Scherer M. J., 2012, ASSISTIVE TECHNOLOGI
Scherer MJ, 2011, DISABIL REHABIL, V33, P811, DOI 10.3109/09638288.2010.511418
Seelye Adriana M, 2012, IEEE Rev Biomed Eng, V5, P29, DOI 10.1109/RBME.2012.2196691
Seelye AM, 2013, J INT NEUROPSYCH SOC, V19, P442, DOI 10.1017/S135561771200149X
Shih CH, 2012, RES DEV DISABIL, V33, P2013, DOI 10.1016/j.ridd.2012.05.021
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Spriggs AD, 2007, EDUC TRAIN DEV DISAB, V42, P209
Sunderland N, 2009, DISABIL SOC, V24, P703, DOI 10.1080/09687590903160175
Svoboda E, 2012, NEUROPSYCHOL REHABIL, V22, P408, DOI 10.1080/09602011.2011.652498
Waldron B., 2012, IRISH J PSYCHOL, V33, P29, DOI [10.1080/03033910.2012.659044, DOI 10.1080/03033910.2012.659044]
NR 51
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2014
VL 26
IS 3
BP 347
EP 355
DI 10.1007/s10882-014-9373-5
PG 9
WC Rehabilitation
SC Rehabilitation
GA AF4LV
UT WOS:000334685100009
ER
PT J
AU Iao, LS
Leekam, SR
AF Iao, Lai-Sang
Leekam, Susan R.
TI Nonspecificity and theory of mind: New evidence from a nonverbal
false-sign task and children with autism spectrum disorders
SO JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
LA English
DT Article
DE Representational understanding; Theory of mind; False sign; Language;
Executive function; Autism spectrum disorders
ID TEMPORO-PARIETAL JUNCTION; BELIEF TASK; ACTION ANTICIPATION;
REPRESENTATIONS; PERFORMANCE; UNDERSTAND; INFANTS; PRESCHOOLERS;
ATTRIBUTION; LANGUAGE
AB Understanding of false belief has long been considered to be a crucial aspect of "theory of mind" that can be explained by a domain-specific mechanism. We argue against this claim using new evidence from a nonverbal false representation task (false-sign task) with typically developing children and children with autism spectrum disorders (ASD). Experiments 1 and 2 showed that typically developing children (mean age = 62.67 months) were equivalent in their performance across nonverbal and verbal forms of both the false-belief and false-sign tasks. Results for these two misrepresentation tasks differed from the results of an outdated representation task ("false"-photograph task). Experiment 3 showed that children with ASD had difficulties with the false representation tasks, and this could not be explained by executive functioning or language impairments. These findings support the view that children with ASD might not have a specific theory-of-mind deficit. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Iao, Lai-Sang; Leekam, Susan R.] Cardiff Univ, Sch Psychol, Wales Autism Res Ctr, Cardiff CF10 3AT, S Glam, Wales.
RP Iao, LS (reprint author), Univ Hong Kong, Ctr Commun Disorders, 7-F Meng Wah Complex, Pokfulam, Hong Kong, Peoples R China.
EM llsi@hku.hk
CR Aichhorn M, 2009, J COGNITIVE NEUROSCI, V21, P1179, DOI 10.1162/jocn.2009.21082
American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th
Apperly IA, 2004, J COGNITIVE NEUROSCI, V16, P1773, DOI 10.1162/0898929042947928
Apperly l., 2007, COGNITION, V103, P300
BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Begeer S, 2008, DEV REV, V28, P342, DOI 10.1016/j.dr.2007.09.001
Begeer S, 2012, AUTISM, V16, P357, DOI 10.1177/1362361311434545
Bowler DM, 2005, J COGN DEV, V6, P259, DOI 10.1207/s15327647jcd0602_5
Call J, 1999, CHILD DEV, V70, P381, DOI 10.1111/1467-8624.00028
Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
CHARMAN T, 1992, J CHILD PSYCHOL PSYC, V33, P1105, DOI 10.1111/j.1469-7610.1992.tb00929.x
Cohen AS, 2010, COGNITION, V115, P417, DOI 10.1016/j.cognition.2010.03.001
de Villiers J. G., 2000, UNDERSTANDING OTHER, P83
de Villiers P. A., 2000, CHILDRENS REASONING, P191
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Figueras-Costa B., 2001, J DEAF STUD DEAF EDU, V6, P92, DOI DOI 10.1093/DEAFED/6.2.92
Grant CM, 2007, J ABNORM CHILD PSYCH, V35, P17, DOI 10.1007/s10802-006-9077-0
Hamilton AFD, 2009, J CHILD PSYCHOL PSYC, V50, P881, DOI 10.1111/j.1469-7610.2009.02098.x
HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
lao L-S., 2011, J COGN DEV, V12, P56
Leekam S, 2008, BRIT J DEV PSYCHOL, V26, P485, DOI 10.1348/026151007X260154
LEEKAM SR, 1991, COGNITION, V40, P203, DOI 10.1016/0010-0277(91)90025-Y
Leslie AM, 2004, TRENDS COGN SCI, V8, P528, DOI 10.1016/j.tics.2004.10.001
Onishi KH, 2005, SCIENCE, V308, P255, DOI 10.1126/science.1107621
Parkin Li, 1994, THESIS U SUSSEX
Paynter J, 2010, RES AUTISM SPECT DIS, V4, P377, DOI 10.1016/j.rasd.2009.10.005
Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287
Perner J, 2006, SOC NEUROSCI, V1, P245, DOI 10.1080/17470910600989896
Perner J, 2005, SCIENCE, V308, P214, DOI 10.1126/science.1111656
Perner Josef, 1991, UNDERSTANDING REPRES
PRATT C, 1990, CHILD DEV, V61, P973, DOI 10.1111/j.1467-8624.1990.tb02835.x
Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
Roid G., 1997, LEITER INT PERFORMAN
Ruffman T, 2001, J CHILD PSYCHOL PSYC, V42, P1083, DOI 10.1111/1469-7610.00807
Ruffman T, 2005, TRENDS COGN SCI, V9, P462, DOI 10.1016/j.tics.2005.08.001
Russell J, 1999, DEVELOPMENTAL SCI, V2, P247, DOI 10.1111/1467-7687.00072
Russell J, 1999, J CHILD PSYCHOL PSYC, V40, P859, DOI 10.1017/S0021963099004229
Sabbagh M. A., 2006, CHILD DEV, V77, P1034
Schneider D, 2012, PSYCHOL SCI, V23, P842, DOI 10.1177/0956797612439070
Senju A, 2010, DEV PSYCHOPATHOL, V22, P353, DOI 10.1017/S0954579410000106
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Slaughter V, 1998, CHILD DEV, V69, P321, DOI 10.1111/j.1467-8624.1998.tb06191.x
Southgate V, 2007, PSYCHOL SCI, V18, P587, DOI 10.1111/j.1467-9280.2007.01944.x
Wellman H. M., 1990, CHILDS THEORY MIND
Wellman HM, 2001, CHILD DEV, V72, P655, DOI 10.1111/1467-8624.00304
WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
World Health Organization, 1993, INT CLASS DIS
Yirimiya N., 1998, PSYCHOL BULL, V124, P283
ZAITCHIK D, 1990, COGNITION, V35, P41, DOI 10.1016/0010-0277(90)90036-J
NR 51
TC 2
Z9 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-0965
EI 1096-0457
J9 J EXP CHILD PSYCHOL
JI J. Exp. Child Psychol.
PD JUN
PY 2014
VL 122
BP 1
EP 20
DI 10.1016/j.jecp.2013.11.017
PG 20
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA AF7NB
UT WOS:000334900700001
PM 24508666
ER
PT J
AU Li, J
Ji, HF
Cao, L
Zang, D
Gu, R
Xia, B
Wu, Q
AF Li, Jie
Ji, Hongfei
Cao, Lei
Zang, Di
Gu, Rong
Xia, Bin
Wu, Qiang
TI EVALUATION AND APPLICATION OF A HYBRID BRAIN COMPUTER INTERFACE FOR REAL
WHEELCHAIR PARALLEL CONTROL WITH MULTI-DEGREE OF FREEDOM
SO INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
LA English
DT Article
DE Electroencephalogram; hybrid brain-computer interface; wheelchair;
parallel control; multi-degree of freedom
ID SINGLE-TRIAL EEG; FUZZY SYNCHRONIZATION LIKELIHOOD; WAVELET-CHAOS
METHODOLOGY; MILD COGNITIVE IMPAIRMENT; AUTISM SPECTRUM DISORDER;
ALZHEIMERS-DISEASE; COMPONENT ANALYSIS; ASYNCHRONOUS BCI;
NEURAL-NETWORK; MOTOR IMAGERY
AB There have been many attempts to design brain-computer interfaces (BCIs) for wheelchair control based on steady state visual evoked potential (SSVEP), event-related desynchronization/synchronization (ERD/ERS) during motor imagery (MI) tasks, P300 evoked potential, and some hybrid signals. However, those BCI systems cannot implement the wheelchair navigation flexibly and effectively. In this paper, we propose a hybrid BCI scheme based on two-class MI and four-class SSVEP tasks. It cannot only provide multi- degree control for its user, but also allow the user implement the different types of commands in parallel. In order for the subject to learn the hybrid mental strategies effectively, we design a visual and auditory cues and feedback-based training paradigm. Furthermore, an algorithm based on entropy of classification probabilities is proposed to detect intentional control (IC) state for hybrid tasks, and ensure that multi-degree control commands are accurately and quickly generated. The experiment results attest to the efficiency and flexibility of the hybrid BCI for wheelchair control in the real- world.
C1 [Li, Jie; Ji, Hongfei; Cao, Lei; Zang, Di] Tongji Univ, Dept Comp Sci & Technol, Shanghai 200092, Peoples R China.
[Gu, Rong] Tongji Univ, Dept Elect Sci & Technol, Shanghai 200092, Peoples R China.
[Xia, Bin] Shanghai Maritime Univ, Inst Informat Engn, Shanghai 201306, Peoples R China.
[Xia, Bin] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72076 Tubingen, Germany.
[Wu, Qiang] Shandong Univ, Sch Informat Sci & Engn, Jinan 250100, Peoples R China.
RP Ji, HF (reprint author), Tongji Univ, Dept Comp Sci & Technol, 4800 Cao An Highway, Shanghai 200092, Peoples R China.
EM nijanice@gmail.com; jh410@duke.edu; scallray@163.com;
zangdi@tongji.edu.cn; gurong2001@163.com; bin.xia@uni-tuebingen.de;
wuqiang@sdu.edu.cn
FU Fundamental Research Funds for the Central Universities [0800219202];
National Natural Science Foundation of China [61105122, 61103071,
61272271, 61305060]; Excellent Youth and Middle Age Scientists Fund of
Shandong Province [BS2012DX020]; Natural Science Foundation Program of
Shanghai [11ZR1440200, 12ZR1434000]; Specialized Research Fund for the
Doctoral Program of Higher Education [20110072120065, 20130131120025]
FX The work was supported by the Fundamental Research Funds for the Central
Universities (Grant No. 0800219202), the National Natural Science
Foundation of China (Grant Nos. 61105122, 61103071, 61272271 and
61305060), the Excellent Youth and Middle Age Scientists Fund of
Shandong Province (Grant No. BS2012DX020), Natural Science Foundation
Program of Shanghai (Grant Nos. 11ZR1440200 and 12ZR1434000) and
Specialized Research Fund for the Doctoral Program of Higher Education
(Grant Nos. 20110072120065 and 20130131120025).
CR Adeli H, 2010, AUTOMATED EEG-BASED DIAGNOSIS OF NEUROLOGICAL DISORDERS: INVENTING THE FUTURE OF NEUROLOGY, P1, DOI 10.1201/9781439815328
Adeli H, 2005, CLIN EEG NEUROSCI, V36, P131
Adeli H, 2008, NEUROSCI LETT, V444, P190, DOI 10.1016/j.neulet.2008.08.008
Adeli H, 2007, IEEE T BIO-MED ENG, V54, P205, DOI 10.1109/TBME.2006.886855
Adeli H, 2003, J NEUROSCI METH, V123, P69, DOI 10.1016/S0165-0270(02)00340-0
Ahmadlou M, 2011, NEUROIMAGE, V58, P401, DOI 10.1016/j.neuroimage.2011.04.070
Ahmadlou M, 2010, J CLIN NEUROPHYSIOL, V27, P328, DOI 10.1097/WNP.0b013e3181f40dc8
Ahmadlou M, 2012, INT J PSYCHOPHYSIOL, V85, P206, DOI 10.1016/j.ijpsycho.2012.05.001
Ahmadlou M, 2011, CLIN EEG NEUROSCI, V42, P6
Ahmadlou M, 2012, J NEUROSCI METH, V211, P203, DOI 10.1016/j.jneumeth.2012.08.020
Ahmadlou M, 2012, PHYSICA A, V391, P4720, DOI 10.1016/j.physa.2012.04.025
Ahmadlou M, 2013, CLIN EEG NEUROSCI, V44, P175, DOI 10.1177/1550059413480504
Ahmadlou M, 2014, CLIN NEUROPHYSIOL, V125, P694, DOI 10.1016/j.clinph.2013.08.033
Akram F., 2013, BRAIN COMP INT BCI 2, P24
Allison BZ, 2010, J NEURAL ENG, V7, DOI 10.1088/1741-2560/7/2/026007
Bin GY, 2009, J NEURAL ENG, V6, DOI 10.1088/1741-2560/6/4/046002
Birbaumer N, 2000, IEEE T REHABIL ENG, V8, P190, DOI 10.1109/86.847812
Blankertz B, 2002, ADV NEUR IN, V14, P157
Brunner C, 2011, J NEURAL ENG, V8, DOI 10.1088/1741-2560/8/2/025010
Cecotti H, 2010, IEEE T NEUR SYS REH, V18, P127, DOI 10.1109/TNSRE.2009.2039594
Chih-Chung C., 2011, ACM T INTEL SYST TEC, V2, P1, DOI [DOI 10.1145/1961189.1961199, 10.1145/1961189.1961199]
Delorme A, 2004, J NEUROSCI METH, V134, P9, DOI 10.1016/j.jneumeth.2003.10.009
Diez PF, 2011, J NEUROENG REHABIL, V8, DOI 10.1186/1743-0003-8-39
FARWELL LA, 1988, ELECTROEN CLIN NEURO, V70, P510, DOI 10.1016/0013-4694(88)90149-6
Gao XR, 2003, IEEE T NEUR SYS REH, V11, P137, DOI 10.1109/TNSRE.2003.814449
Ghosh-Dastidar S, 2008, IEEE T BIO-MED ENG, V55, P512, DOI 10.1109/TBME.2007.905490
Guger C, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00169
Horki P, 2011, MED BIOL ENG COMPUT, V49, P567, DOI 10.1007/s11517-011-0750-2
Huang DD, 2012, IEEE T NEUR SYS REH, V20, P379, DOI 10.1109/TNSRE.2012.2190299
Iturrate I, 2009, IEEE T ROBOT, V25, P614, DOI 10.1109/TRO.2009.2020347
Jelic V, 2000, NEUROBIOL AGING, V21, P533, DOI 10.1016/S0197-4580(00)00153-6
Jin J, 2012, MED BIOL ENG COMPUT, V50, P289, DOI 10.1007/s11517-012-0868-x
Kaplan AY, 2013, IEEE T COMP INTEL AI, V5, P141, DOI 10.1109/TCIAIG.2012.2237517
Leeb R., 2007, COMPUT INTEL NEUROSC, V4, p1687C
Li J., 2013, NEURAL INFORM PROCES, P434
Li JH, 2013, INT J NEURAL SYST, V23, DOI 10.1142/S0129065713500135
Li YQ, 2013, IEEE T BIO-MED ENG, V60, P3156, DOI 10.1109/TBME.2013.2270283
Lin ZL, 2006, IEEE T BIO-MED ENG, V53, P2610, DOI 10.1109/TBME.2006.886577
Long JY, 2012, IEEE T NEUR SYS REH, V20, P720, DOI 10.1109/TNSRE.2012.2197221
Lotte F., 2008, 19 INT C ICPR 2008 I, P1
Mandel C, 2009, 2009 IEEE-RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS, P1118, DOI 10.1109/IROS.2009.5354534
Mason S. G., EVALUATING PERFORMAN
Millan JD, 2003, IEEE T NEUR SYS REH, V11, P159, DOI 10.1109/TNSRE.2003.814435
Mun S., 2012, SOC PHOTOOPT INSTRUM, V8384, P25
Ortiz-Rosario A, 2013, REV NEUROSCIENCE, V24, P537, DOI 10.1515/revneuro-2013-0032
Pfurtscheller G, 2001, P IEEE, V89, P1123, DOI 10.1109/5.939829
Pfurtscheller G, 2010, FRONT NEUROSCI, V4, P4, DOI DOI 10.3389/FNPRO.2010.00003
Ramoser H, 2000, IEEE T REHABIL ENG, V8, P441, DOI 10.1109/86.895946
Rebsamen B., 2008, P 2 INT CONV REH ENG, P51
Rebsamen B., 2006, 1 IEEE RAS EMBS INT, P1101, DOI 10.1109/BIOROB.2006.1639239
Rebsamen B, 2010, IEEE T NEUR SYS REH, V18, P590, DOI 10.1109/TNSRE.2010.2049862
Sankari Z, 2011, J NEUROSCI METH, V197, P165, DOI 10.1016/j.jneumeth.2011.01.027
Sankari Z, 2012, CLIN EEG NEUROSCI, V43, P268, DOI 10.1177/1550059412444970
Scherer R, 2007, COMP INT NEUROSC, V2007, P79826, DOI DOI 10.1155/2007/79826
Scherer R, 2008, IEEE T BIO-MED ENG, V55, P675, DOI 10.1109/TBME.2007.903709
Seno B. D., 2010, COMPUT INTEL NEUROSC, V2010, P11
Singla R., 2013, INT J SOFT COMPUT EN, V3, P46
Tsui CSL, 2011, CLIN EEG NEUROSCI, V42, P225
Vuckovic A, 2009, CLIN NEUROPHYSIOL, V120, P1422, DOI 10.1016/j.clinph.2009.06.007
Wu TF, 2004, J MACH LEARN RES, V5, P975
Zhang D., 2007, COMPUT INTEL NEUROSC, V2007, DOI [10.1155/2007/39714, DOI 10.1155/2007/39714]
Zhang Y, 2012, J NEURAL ENG, V9, DOI 10.1088/1741-2560/9/2/026018
NR 62
TC 4
Z9 4
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0129-0657
EI 1793-6462
J9 INT J NEURAL SYST
JI Int. J. Neural Syst.
PD JUN
PY 2014
VL 24
IS 4
AR 1450014
DI 10.1142/S0129065714500142
PG 15
WC Computer Science, Artificial Intelligence
SC Computer Science
GA AE8VU
UT WOS:000334281800004
PM 24694169
ER
PT J
AU Yuan, Q
Zhou, WD
Yuan, SS
Li, XL
Wang, JW
Jia, GJ
AF Yuan, Qi
Zhou, Weidong
Yuan, Shasha
Li, Xueli
Wang, Jiwen
Jia, Guijuan
TI EPILEPTIC EEG CLASSIFICATION BASED ON KERNEL SPARSE REPRESENTATION
SO INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
LA English
DT Article
DE Epileptic EEG; differentiation; sparse representation; kernel trick
ID FUZZY SYNCHRONIZATION LIKELIHOOD; AUTISM SPECTRUM DISORDER;
ALZHEIMERS-DISEASE; FEATURE-EXTRACTION; SEIZURE DETECTION; SIGNAL
RECOVERY; BRAIN; DIAGNOSIS; RECOGNITION; METHODOLOGY
AB The automatic identification of epileptic EEG signals is significant in both relieving heavy workload of visual inspection of EEG recordings and treatment of epilepsy. This paper presents a novel method based on the theory of sparse representation to identify epileptic EEGs. At first, the raw EEG epochs are preprocessed via Gaussian low pass filtering and differential operation. Then, in the scheme of sparse representation based classification (SRC), a test EEG sample is sparsely represented on the training set by solving l(1)-minimization problem, and the represented residuals associated with ictal and interictal training samples are computed. The test EEG sample is categorized as the class that yields the minimum represented residual. So unlike the conventional EEG classification methods, the choice and calculation of EEG features are avoided in the proposed framework. Moreover, the kernel trick is employed to generate a kernel version of the SRC method for improving the separability between ictal and interictal classes. The satisfactory recognition accuracy of 98.63% for ictal and interictal EEG classification and for ictal and normal EEG classification has been achieved by the kernel SRC. In addition, the fast speed makes the kernel SRC suit for the real-time seizure monitoring application in the near future.
C1 [Yuan, Qi; Zhou, Weidong; Yuan, Shasha; Li, Xueli] Shandong Univ, Sch Informat Sci & Engn, Jinan 250100, Peoples R China.
[Yuan, Qi; Zhou, Weidong; Yuan, Shasha; Li, Xueli] Shandong Univ, Suzhou Inst, Suzhou 215123, Peoples R China.
[Wang, Jiwen; Jia, Guijuan] Shandong Univ, Qilu Hosp, Jinan 250100, Peoples R China.
RP Zhou, WD (reprint author), Shandong Univ, Sch Informat Sci & Engn, Jinan 250100, Peoples R China.
EM wdzhou@sdu.edu.cn
FU Natural Science Foundation of Shandong Province [ZR2013FZ002]; Program
of Science and Technology of Suzhou [ZXY2013030]; Independent Innovation
Foundation of Shandong University, China [2012DX008]
FX The support of the Key Program of Natural Science Foundation of Shandong
Province (No. ZR2013FZ002), the Program of Science and Technology of
Suzhou (No. ZXY2013030), and the Independent Innovation Foundation of
Shandong University (No. 2012DX008), China is gratefully acknowledged.
CR Acharya UR, 2011, INT J NEURAL SYST, V21, P403, DOI 10.1142/S0129065711002912
Acharya UR, 2012, INT J NEURAL SYST, V22, DOI 10.1142/S0129065712500025
Acharya UR, 2011, INT J NEURAL SYST, V21, P199, DOI 10.1142/S0129065711002808
Acharya UR, 2013, INT J NEURAL SYST, V23, DOI 10.1142/S0129065713500093
Acharya UR, 2012, INT J NEURAL SYST, V22, DOI 10.1142/S0129065712500116
Adeli H., 2010, AUTOMATED EEG BASED, P72
Adeli H, 2005, CLIN EEG NEUROSCI, V36, P131
Adeli H, 2008, NEUROSCI LETT, V444, P190, DOI 10.1016/j.neulet.2008.08.008
Adeli H, 2005, J ALZHEIMERS DIS, V7, P187
Adeli H, 2003, J NEUROSCI METH, V123, P69, DOI 10.1016/S0165-0270(02)00340-0
Ahmadlou M, 2011, NEUROIMAGE, V58, P401, DOI 10.1016/j.neuroimage.2011.04.070
Ahmadlou M, 2011, CLIN EEG NEUROSCI, V42, P6
Ahmadlou M, 2010, CLIN EEG NEUROSCI, V41, P1
Ahmadlou M, 2012, J NEUROSCI METH, V211, P203, DOI 10.1016/j.jneumeth.2012.08.020
Ahmadlou M, 2012, PHYSICA A, V391, P4720, DOI 10.1016/j.physa.2012.04.025
Ahmadlou M, 2013, CLIN EEG NEUROSCI, V44, P175, DOI 10.1177/1550059413480504
Ahmadlou M, 2012, CLIN EEG NEUROSCI, V43, P5, DOI 10.1177/1550059411428555
Andrzejak RG, 2001, PHYS REV E, V64, DOI 10.1103/PhysRevE.64.061907
Boyd S., 2004, CONVEX OPTIMIZATION
Candes EJ, 2008, IEEE SIGNAL PROC MAG, V25, P21, DOI 10.1109/MSP.2007.914731
Candes EJ, 2006, COMMUN PUR APPL MATH, V59, P1207, DOI 10.1002/cpa.20124
Candes EJ, 2006, IEEE T INFORM THEORY, V52, P5406, DOI 10.1109/TIT.2006.885507
Diambra L, 1999, PHYSICA A, V273, P495, DOI 10.1016/S0378-4371(99)00368-4
Fisher RS, 2005, EPILEPSIA, V46, P470, DOI 10.1111/j.0013-9580.2005.66104.x
Good LB, 2009, INT J NEURAL SYST, V19, P173, DOI 10.1142/S0129065709001951
GOTMAN J, 1990, ELECTROEN CLIN NEURO, V76, P317, DOI 10.1016/0013-4694(90)90032-F
GOTMAN J, 1982, ELECTROEN CLIN NEURO, V54, P530, DOI 10.1016/0013-4694(82)90038-4
Guo L, 2009, WORLD SUMMIT ON GENETIC AND EVOLUTIONARY COMPUTATION (GEC 09), P177
Jahangiri A, 2011, INT J NEURAL SYST, V21, P127, DOI 10.1142/S0129065711002705
Kannathal N, 2005, COMPUT METH PROG BIO, V80, P187, DOI 10.1016/j.cmpb.2005.06.012
Kim SJ, 2007, IEEE J-STSP, V1, P606, DOI 10.1109/JSTSP.2007.910971
Kumar SP, 2010, EXPERT SYST APPL, V37, P3284, DOI 10.1016/j.eswa.2009.09.051
Lehnertz K, 2003, IEEE ENG MED BIOL, V22, P57, DOI 10.1109/MEMB.2003.1191451
Li SF, 2013, COMPUT BIOL MED, V43, P807, DOI 10.1016/j.compbiomed.2013.04.002
Majumdar KK, 2011, IEEE T NEUR SYS REH, V19, P356, DOI 10.1109/TNSRE.2011.2157525
Martis RJ, 2013, INT J NEURAL SYST, V23, DOI 10.1142/S0129065713500238
Michel CM, 2012, NEUROIMAGE, V61, P371, DOI 10.1016/j.neuroimage.2011.12.039
Nelson TS, 2011, INT J NEURAL SYST, V21, P163, DOI 10.1142/S0129065711002717
Olson LD, 2013, INT J NEURAL SYST, V23, DOI 10.1142/S012906571230001X
Polat K, 2007, APPL MATH COMPUT, V187, P1017, DOI 10.1016/j.amc.2006.09.022
Rodriguez-Bermudez G, 2013, INT J NEURAL SYST, V23, DOI 10.1142/S0129065713500159
Sanei S, 2007, EEG SIGNAL PROCESSIN, P161
Sankari Z, 2011, CLIN NEUROPHYSIOL, V122, P897, DOI 10.1016/j.clinph.2010.09.008
Sankari Z, 2012, CLIN EEG NEUROSCI, V43, P268, DOI 10.1177/1550059412444970
Sherman D, 2011, INT J NEURAL SYST, V21, P115, DOI 10.1142/S0129065711002754
Shoeb A, 2009, INT J NEURAL SYST, V19, P157, DOI 10.1142/S0129065709001938
Shorvon S., 2009, EPILEPSY, P1
Subasi A, 2007, EXPERT SYST APPL, V32, P1084, DOI 10.1016/j.eswa.2006.02.005
Temko A, 2011, CLIN NEUROPHYSIOL, V122, P464, DOI 10.1016/j.clinph.2010.06.034
Ubeyli ED, 2010, EXPERT SYST APPL, V37, P985, DOI 10.1016/j.eswa.2009.05.078
Wang Y, 2013, INT J NEURAL SYST, V23, DOI 10.1142/S0129065713500287
White AM, 2006, J NEUROSCI METH, V152, P255, DOI 10.1016/j.jneumeth.2005.09.014
Wright J, 2009, IEEE T PATTERN ANAL, V31, P210, DOI 10.1109/TPAMI.2008.79
Xu BX, 2014, INTEGR COMPUT-AID E, V21, P91, DOI 10.3233/ICA-130451
Yang S., 2012 P INT JOINT C N, P1
Yuan Q, 2011, EPILEPSY RES, V96, P29, DOI 10.1016/j.eplepsyres.2011.04.013
Zhang C, 2013, INTEGR COMPUT-AID E, V20, P391, DOI 10.3233/ICA-130439
Zhang L, 2012, IEEE T SIGNAL PROCES, V60, P1684, DOI 10.1109/TSP.2011.2179539
NR 58
TC 4
Z9 4
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0129-0657
EI 1793-6462
J9 INT J NEURAL SYST
JI Int. J. Neural Syst.
PD JUN
PY 2014
VL 24
IS 4
AR 1450015
DI 10.1142/S0129065714500154
PG 13
WC Computer Science, Artificial Intelligence
SC Computer Science
GA AE8VU
UT WOS:000334281800005
PM 24694170
ER
PT J
AU Calvo, A
Moglia, C
Canosa, A
Brunetti, M
Barberis, M
Traynor, BJ
Carrara, G
Valentini, C
Restagno, G
Chio, A
AF Calvo, Andrea
Moglia, Cristina
Canosa, Antonio
Brunetti, Maura
Barberis, Marco
Traynor, Bryan J.
Carrara, Giovanna
Valentini, Consuelo
Restagno, Gabriella
Chio, Adriano
TI A de novo nonsense mutation of the FUS gene in an apparently familial
amyotrophic lateral sclerosis case
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Amyotrophic lateral sclerosis; FUS; de novo mutation
ID HEXANUCLEOTIDE REPEAT; ALS; C9ORF72; AUTISM; SCHIZOPHRENIA; PHENOTYPE;
FTD
AB Mutations in C9ORF72, SOD1, TARDBP, and FUS genes account for approximately two-third of familial cases and 5% of sporadic amyotrophic lateral sclerosis (ALS) cases. We present the first case of an ALS patient carrying a de novo nonsense mutation in exon 14 of the FUS gene (c.1483c>t; p.R495X) with an apparently familial ALS. This mutation causes a phenotype characterized by a young age at onset, a rapid course (<24 months), and a bulbar onset with early respiratory involvement with a predominant lower motor neuron disease. De novo mutations could account for a sizable number of apparently sporadic ALS patients carrying mutations of ALS-related genes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Calvo, Andrea; Moglia, Cristina; Canosa, Antonio; Chio, Adriano] Univ Turin, Rita Levi Montalcini Dept Neurosci, ALS Ctr, I-10126 Turin, Italy.
[Brunetti, Maura; Barberis, Marco; Restagno, Gabriella] Azienda Osped Citta Salute & Sci, Mol Genet Lab, Turin, Italy.
[Traynor, Bryan J.] NIA, Neuromuscular Dis Res Unit, Neurogenet Lab, NIH, Bethesda, MD 20892 USA.
[Carrara, Giovanna; Valentini, Consuelo] Dept Neuroradiol, Azienda Osped Citta Salute & Sci, Dept Neuroradiol, Turin, Italy.
[Chio, Adriano] Neurosci Inst Torino, Turin, Italy.
RP Calvo, A (reprint author), Univ Turin, Rita Levi Montalcini Dept Neurosci, ALS Ctr, Via Cherasco 15, I-10126 Turin, Italy.
EM achio@usa.net
FU Fondazione Vialli e Mauro for ALS Research Onlus; Federazione Italiana
Giuoco Calcio; Ministero della Salute [RF-PIE-2007-635695,
RF-2010-2309849]; Joint Programmed-Neurodegenerative Disease Research
(Strength Project); European Community [259867]; Intramural Research
Program of the National Institutes of Health and the National Institute
on Aging [Z01 AG000949-02]
FX Adriano Chio had full access to all the data in the study and takes
responsibility for the integrity of the data and the accuracy of the
data analysis. We thank the patient and her family for having
collaborated to this study. This work was funded by grants of Fondazione
Vialli e Mauro for ALS Research Onlus, Federazione Italiana Giuoco
Calcio, Ministero della Salute (Ricerca Sanitaria Finalizzata 2007,
grant RF-PIE-2007-635695, and 2010, grant RF-2010-2309849), and Joint
Programmed-Neurodegenerative Disease Research (Strength Project). The
research leading to these results has received funding from the European
Community's Health Seventh Framework Programme (FP7/2007-2013) (grant
agreement no. 259867). This work was supported in part by the Intramural
Research Program of the National Institutes of Health and the National
Institute on Aging (project Z01 AG000949-02). Funding organizations had
no role in design and conduct of the study; collection, management,
analysis, and interpretation of the data; and preparation, review, or
approval of the manuscript.
CR Alexander MD, 2002, ANN NEUROL, V52, P680, DOI 10.1002/ana.10369
Belzil VV, 2011, J HUM GENET, V56, P247, DOI 10.1038/jhg.2010.162
BISGAARD ML, 1994, HUM MUTAT, V3, P121, DOI 10.1002/humu.1380030206
Bosco DA, 2010, HUM MOL GENET, V19, P4160, DOI 10.1093/hmg/ddq335
Byrne S, 2011, AMYOTROPH LATERAL SC, V12, P157, DOI 10.3109/17482968.2010.545420
Chesi A, 2013, NAT NEUROSCI, V16, P851, DOI 10.1038/nn.3412
Chio A, 2012, NEUROLOGY, V79, P1983, DOI 10.1212/WNL.0b013e3182735d36
Chio A, 2009, NEUROLOGY, V72, P725, DOI 10.1212/01.wnl.0000343008.26874.d1
Chio A., 2011, NEUROBIOL AGING, V32
Chio A, 2013, J NEUROL NEUROSURG P
Conte A, 2012, NEUROMUSCULAR DISORD, V22, P73, DOI 10.1016/j.nmd.2011.08.003
DeJesus-Hernandez M, 2011, NEURON, V72, P245, DOI 10.1016/j.neuron.2011.09.011
DeJesus-Hernandez M, 2010, HUM MUTAT, V31, pE1377, DOI 10.1002/humu.21241
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Grimm Tiemo, 2012, Acta Myol, V31, P179
Kenna KP, 2013, J MED GENET, V50, P776, DOI 10.1136/jmedgenet-2013-101795
Kwiatkowski Jr, 2009, SCIENCE, V323, P1205
Kwon MJ, 2012, NEUROBIOL AGING, V33, P1017
Lai S. L., 2010, NEUROBIOL AGING, V32
Millecamps S, 2012, J MED GENET, V49, P258, DOI 10.1136/jmedgenet-2011-100699
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Renton AE, 2011, NEURON, V72, P257, DOI 10.1016/j.neuron.2011.09.010
ROSEN DR, 1993, NATURE, V362, P59, DOI 10.1038/362059a0
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sreedharan J, 2008, SCIENCE, V319, P1668, DOI 10.1126/science.1154584
van Blitterswijk M, 2012, HUM MOL GENET, V21, P3776, DOI 10.1093/hmg/dds199
Waibel S, 2013, EUR J NEUROL, V20, P540, DOI 10.1111/ene.12031
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Yan J, 2010, NEUROLOGY, V75, P807, DOI 10.1212/WNL.0b013e3181f07e0c
Zou ZY, 2013, NEUROBIOL AGING, V34, pe1
NR 31
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD JUN
PY 2014
VL 35
IS 6
AR 1513.e7
DI 10.1016/j.neurobiolaging.2013.12.028
PG 5
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA AE4RO
UT WOS:000333970800042
PM 24439481
ER
PT J
AU Schindler, VP
AF Schindler, Victoria P.
TI Community Engagement: Outcomes for Occupational Therapy Students,
Faculty and Clients
SO OCCUPATIONAL THERAPY INTERNATIONAL
LA English
DT Article
DE supported education and employment; faculty scholarship; community
engagement; health care students
ID MENTAL-ILLNESS; EMPLOYMENT; EDUCATION; PROGRAM; INDIVIDUALS; ATTITUDES;
ADULTS
AB Students in health care professions, including occupational therapy, are required to develop knowledge, skills and attitudes in mental health and research. Persons diagnosed with a mental illness, a learning disability or an autism-spectrum disorder desire to achieve goals in higher education and employment. Faculty in health care programmes strives to meet professional goals and accreditation and institution requirements for teaching, service and scholarship. The Bridge Program, a programme based on principles of community engagement, was developed to meet the needs of these three stakeholders. The objective of this paper is to provide programme description and outcomes of the effectiveness of the Bridge Program for all three stakeholders. This uses mixed methods research design including descriptive and quantitative and qualitative one-group pre-test-post-test designs. Instruments consisted of the Occupational Therapy Student and Mental Health Population Scale and the Canadian Occupational Performance Measure. Quantitative results support that graduate occupational therapy students gained research and clinical skills (n = 100; p = .000); clients increased performance and satisfaction toward goals (n = 113; p = .000) and faculty (n = 1) achieved goals related to teaching, service and scholarship. Programmes based on principles of community engagement can address the needs of the community, can provide outcomes that advance knowledge about community practice and can result in benefits for all stakeholders. This paper is limited to generalization and instrumentation and recommends an ongoing evaluation of other community engagement programmes involving all stakeholders in the future research. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Schindler, Victoria P.] Richard Stockton Coll New Jersey, Galloway, NJ 08205 USA.
RP Schindler, VP (reprint author), Richard Stockton Coll New Jersey, Sch Hlth Sci, 101 Vera King Farris Dr, Galloway, NJ 08205 USA.
EM Victoria.schindler@stockton.edu
CR Adreon D, 2007, INTERV SCH CLIN, V42, P271, DOI 10.1177/10534512070420050201
[Anonymous], 2011, BOSTON U CTR PSYCHIA
Arbesman M, 2011, AM J OCCUP THER, V65, P238, DOI 10.5014/ajot.2011.001289
Atler Karen, 2010, Occup Ther Health Care, V24, P23, DOI 10.3109/07380570903410860
Balakas K, 2010, J NURS EDUC, V49, P691, DOI 10.3928/01484834-20100831-07
Bazyk Susan, 2010, Occup Ther Health Care, V24, P171, DOI 10.3109/07380571003681194
Beltran RO, 2007, AUST OCCUP THER J, V54, P42, DOI 10.1111/j.1440-1630.2006.00619.x
Boyer Ernest, 1990, SCHOLARSHIP RECONSID
Brosnan CA, 2005, PUBLIC HEALTH NURS, V22, P260, DOI 10.1111/j.0737-1209.2005.220310.x
Carnegie Foundation for the Advancement of Teaching, 2013, COMM DESCR COMM ENG
Carpenter C., 2008, QUALITATIVE RES OCCU
Coates Gina L Ferraro, 2004, Occup Ther Health Care, V18, P39, DOI 10.1080/J003v18n01_05
Curry-Stevens A, 2011, J PUBLIC SCHOLARSHIP, V1, P11
Driscoll A, 2008, CHANGE JAN, P39
Eyler J., 1999, WHERES LEARNING SERV
Ferrari J. R., 2000, MICHIGAN J COMMUNITY, V7, P35
Flecky K, 2009, SERVICE LEARNING OCC
Flinn Sharon, 2009, Occup Ther Health Care, V23, P146, DOI 10.1080/07380570902779807
Fossey EM, 2010, CAN J OCCUP THER, V77, P303, DOI 10.2182/cjot.2010.77.5.6
Gardner J, 2012, OCCUPATIONAL THERAPY, V26, P25
Graessle EA, 1997, OCCUPATIONAL THERAPY, V13, P41, DOI 10.1300/J004v13n03_03
Gutman S. A., 2007, OCCUPATIONAL THERAPY, V23, P21, DOI DOI 10.1300/J004V23N01_02
Hutchinson MC, 2011, J PUBLIC SCHOLARSHIP, V1, P133
Hyde CA, 2004, J COMMUNITY PRACTICE, V12, P71
Lashley Mary, 2007, Nurs Educ Perspect, V28, P24
Law M, 1998, CLIENT CTR OCCUPATIO, P37
Law M, 2005, CANADIAN OCCUPATIONA
McColl MA, 2006, RES CANADIAN OCCUPAT
O'Meara KerryAnn, 2008, NEW DIRECTIONS TEACH, P27
Penny NH, 2001, OCCUPATIONAL THERAPY, V17, P49
Peterson SJ, 1999, J NURS EDUC, V38, P208
Portney L. G., 2009, FDN CLIN RES APPL PR
Portney LG, 2006, J PHYS THERAPY ED, V20, P18
Raiz Adele, 2007, Occup Ther Health Care, V21, P61, DOI 10.1080/J003v21n01_05
Rash EM, 2005, J NURS EDUC, V44, P477
Saltmarsh J, 2011, HIGHER EDUCATION AND DEMOCRACY: ESSAYS ON SERVICE-LEARNING AND CIVIC ENGAGEMENT, P1
Schindler Victoria P, 2011, Occup Ther Health Care, V25, P54, DOI 10.3109/07380577.2010.519430
Schindler VP, 2013, WORK, V46, P325, DOI 10.3233/WOR-121548
Schindler VP, 2010, OCCUP THER INT, V17, P105, DOI 10.1002/oti.291
Scobey D, 2011, J PUBLIC SCHOLARSHIP, V1, P1
Stanton T. K., 2012, J HIGHER ED OUTREACH, V16, P271
Stocking VB, 2006, MICHIGAN J COMMUNITY, V13, P56
Strand Kerry J., 2000, MICHIGAN J COMMUNITY, V7, P85
Suarez-Balcazar Y, 2005, OCCUPATIONAL THERAPY, V21, P47
Substance Abuse and Mental Health Services Administration Center for Mental Health Services, 2007, PROM IND REC WORK EM, P1
Tett L, 2003, J EDUC POLICY, V18, P37, DOI 10.1080/0268093032000042191
Tsang HWH, 2004, AM J OCCUP THER, V58, P426
Velde BP, 2009, SERVICE LEARNING OCC, P37
Williams PH, 2011, J PUBLIC SCHOLARSHIP, V1, P31
NR 49
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0966-7903
EI 1557-0703
J9 OCCUP THER INT
JI Occup. Ther. Int.
PD JUN
PY 2014
VL 21
IS 2
BP 71
EP 80
DI 10.1002/oti.1364
PG 10
WC Rehabilitation
SC Rehabilitation
GA AE9HM
UT WOS:000334317300003
PM 24477943
ER
PT J
AU Poslawsky, IE
Naber, FBA
Van Daalen, E
Van Engeland, H
AF Poslawsky, Irina E.
Naber, Fabienne B. A.
Van Daalen, Emma
Van Engeland, Herman
TI Parental Reaction to Early Diagnosis of Their Children's Autism Spectrum
Disorder: An Exploratory Study
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE Autism spectrum disorder; Parenting; Resolution; Early diagnosis; Young
children
ID COMMUNICATIVE DEVELOPMENT INVENTORY; ABERRANT BEHAVIOR CHECKLIST;
PRESCHOOL-CHILDREN; QUOTIENT AQ; MENTAL-RETARDATION; MOTHERS RESOLUTION;
COPING STRATEGIES; ASPERGER-SYNDROME; EARLY-CHILDHOOD; CEREBRAL-PALSY
AB This study explores parental reactions subsequent to receiving their child's autism spectrum disorder (ASD)-diagnosis. Seventy seven parents of recently diagnosed children participated in the Reaction to Diagnosis Interview. Within this group, associations between parental reaction to diagnosis, parental and child characteristics and prediagnostic circumstances were analysed. In a sub-sample, the stability of reaction to diagnosis was examined. The majority of parents were classified as 'resolved' regarding their child's diagnosis. Conversely, parents of children with more severe ASD symptoms or non-Dutch parents were more likely to be classified as 'unresolved'. Sub-sample analysis revealed stability of reaction to ASD-diagnosis. The majority of parents adapted well to the circumstances and the care for their child. Autism severity and parental nationality were significant factors affecting parental reactions. Thus, early identification of parental reaction to children's ASD-diagnosis may aid in providing more tailored parental support programs.
C1 [Poslawsky, Irina E.; Van Daalen, Emma; Van Engeland, Herman] Univ Med Ctr Utrecht, Div Neurosci, Brain Ctr Rudolf Magnus, NL-3508 GA Utrecht, Netherlands.
[Naber, Fabienne B. A.] Leiden Univ, Ctr Child & Family Studies, NL-2300 RA Leiden, Netherlands.
[Naber, Fabienne B. A.] Erasmus Univ, Sch Pedag & Educ Sci, NL-3000 DR Rotterdam, Netherlands.
RP Poslawsky, IE (reprint author), Univ Med Ctr Utrecht, Div Neurosci, Brain Ctr Rudolf Magnus, A01-468,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM I.E.Uitewaal@umcutrecht.nl
CR AMAN MG, 1985, AM J MENT DEF, V89, P492
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Arrindell WA, 1986, SCL 90
Bakermans-Kranenburg MJ, 2003, PSYCHOL BULL, V129, P195, DOI 10.1037/0033-2909.129.2.195
Bakermans-Kranenburg MJ, 1999, PARENTAL EFFIC UNPUB
Bandura A, 1997, SELF EFFICACY EXERCI
Bandura A., 1995, SELF EFFICACY CHANGI, P1, DOI 10.1017/CBO9780511527692.003
Barnett D, 2006, J FAM PSYCHOL, V20, P100, DOI 10.1037/0893-3200.20.1.100
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bekhet Abir K, 2012, Issues Ment Health Nurs, V33, P650
Benjak T, 2009, CROAT MED J, V50, P403, DOI 10.3325/cmj.2009.50.403
Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
Bowlby J., 1969, ATTACHMENT LOSS, V1-3
Brinkley J, 2007, J AUTISM DEV DISORD, V37, P1949, DOI 10.1007/s10803-006-0327-3
Cassidy J., 2008, HDB ATTACHMENT THEOR, V2nd
Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
CRNIC KA, 1990, CHILD DEV, V61, P1628, DOI 10.1111/j.1467-8624.1990.tb02889.x
Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
de Haan AD, 2009, DEV PSYCHOL, V45, P1695, DOI 10.1037/a0016121
DeWolff MS, 1997, CHILD DEV, V68, P571, DOI 10.2307/1132107
Dietz C, 2007, ARCH PEDIAT ADOL MED, V161, P363, DOI 10.1001/archpedi.161.4.363
Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
Fenson L, 1993, GUIDE TECHNICAL MANU
Fenson Larry, 1994, Monographs of the Society for Research in Child Development, V59, P1
Fenson L, 2007, MACARTHUR BATES COMM
Ghaziuddin M, 2005, J AUTISM DEV DISORD, V35, P177, DOI 10.1007/s10803-005-1996-z
GLASCOE FP, 1995, PEDIATRICS, V95, P829
Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
Heilmann J, 2005, AM J SPEECH-LANG PAT, V14, P40, DOI 10.1044/1058-0360(2005/006)
Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Holloway I., 2002, QUALITATIVE RES NURS, V2nd
Ingersoll B, 2011, J AUTISM DEV DISORD, V41, P1646, DOI 10.1007/s10803-011-1192-2
Kandel I, 2007, THESCIENTIFICWORLDJO, V7, P1799, DOI 10.1100/tsw.2007.265
Karabekiroglu K, 2009, CHILD PSYCHIAT HUM D, V40, P99, DOI 10.1007/s10578-008-0108-7
Kearney JA, 2011, CHILD PSYCHIAT HUM D, V42, P334, DOI 10.1007/s10578-011-0217-6
Klusek J, 2014, AUTISM, V18, P106, DOI 10.1177/1362361312464529
KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151
Kose S, 2013, PSYCHIAT CLIN NEUROS, V67, P20, DOI 10.1111/pcn.12005
Lau WYP, 2013, RES DEV DISABIL, V34, P294, DOI 10.1016/j.ridd.2012.08.005
Lord B, 2008, J PEDIATR PSYCHOL, V33, P855, DOI 10.1093/jpepsy/jsn020
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luong J, 2009, J SCH NURS, V25, P222, DOI 10.1177/1059840509334365
Luther Edith H, 2005, J Sch Nurs, V21, P40, DOI 10.1177/10598405050210010901
Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Marvin RS, 1996, J CLIN CHILD PSYCHOL, V25, P436, DOI 10.1207/s15374424jccp2504_8
Micali N, 2004, AUTISM, V8, P21, DOI 10.1177/1362361304040636
Milshtein S, 2010, J AUTISM DEV DISORD, V40, P89, DOI 10.1007/s10803-009-0837-x
Mullen E, 1995, MULLEN SCALES EARLY
Oppenheim D, 2009, CHILD DEV, V80, P519, DOI 10.1111/j.1467-8624.2009.01276.x
Osborne LA, 2008, RES AUTISM SPECT DIS, V2, P707, DOI 10.1016/j.rasd.2008.02.005
Pakenham KI, 2004, RES DEV DISABIL, V25, P245, DOI 10.1016/j.ridd.2003.06.003
Pianta RC, 1996, INF MENTAL HLTH J, V17, P239, DOI 10.1002/(SICI)1097-0355(199623)17:3<239::AID-IMHJ4>3.0.CO;2-J
Pickles A, 2000, J CHILD PSYCHOL PSYC, V41, P491, DOI 10.1017/S0021963099005557
Rentinck ICM, 2010, CHILD CARE HLTH DEV, V36, P703, DOI 10.1111/j.1365-2214.2010.01077.x
Renty J, 2006, CHILD CARE HLTH DEV, V32, P371, DOI 10.1111/j.1365-2214.2006.00584.x
Ruta L, 2012, J AUTISM DEV DISORD, V42, P625, DOI 10.1007/s10803-011-1290-1
Rutgers AH, 2007, J ABNORM CHILD PSYCH, V35, P859, DOI 10.1007/s10802-007-9139-y
Scheeren AM, 2008, J AUTISM DEV DISORD, V38, P276, DOI 10.1007/s10803-007-0389-x
Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
Schlichting J. E. P., 1995, SCHLICHTING TEST TAA
Schuengel C, 2009, CHILD CARE HLTH DEV, V35, P673, DOI 10.1111/j.1365-2214.2009.00951.x
Sheeran T, 1997, J PEDIATR PSYCHOL, V22, P197
Sivberg B, 2002, AUTISM, V6, P397, DOI 10.1177/1362361302006004006
Twoy R, 2007, J AM ACAD NURSE PRAC, V19, P251, DOI 10.1111/j.1745-7599.2007.00222.x
Van Eldik MCM, 1995, REIJNELL TEST TAALBE
Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
Warfield ME, 1999, J DEV BEHAV PEDIATR, V20, P9, DOI 10.1097/00004703-199902000-00002
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
Young RL, 2003, AUTISM, V7, P125, DOI 10.1177/1362361303007002002
Zink I, 2007, N CDI 3 AANPASSING H
Zink I., 2002, N CDIS LIJSTEN COMMU
NR 76
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-398X
EI 1573-3327
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD JUN
PY 2014
VL 45
IS 3
BP 294
EP 305
DI 10.1007/s10578-013-0400-z
PG 12
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AE5TE
UT WOS:000334051400004
PM 23959534
ER
PT J
AU Nuske, HJ
Vivanti, G
Dissanayake, C
AF Nuske, Heather J.
Vivanti, Giacomo
Dissanayake, Cheryl
TI Reactivity to fearful expressions of familiar and unfamiliar people in
children with autism: an eye-tracking pupillometry study
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Emotion; Familiarity; Physiological reactivity; Pupillometry;
Eye-tracking; Response latency
ID FACIAL-EMOTION RECOGNITION; SPECTRUM DISORDER; YOUNG-CHILDREN;
ASPERGER-SYNDROME; FACE RECOGNITION; IMPAIRED RECOGNITION; PUPILLARY
RESPONSES; 6-MONTH-OLD INFANTS; PERSON FAMILIARITY; NEURAL CIRCUITRY
AB Background: Individuals with autism are often reported to have difficulty with emotion processing. However, clinical and experimental data show that they are sensitive to familiarity; for example, they show normative attachment to familiar people, and have normative brain activity in response to familiar faces. To date, no study has measured their reactivity to the emotions of familiar vs. unfamiliar people. Thus, our aim was to determine whether individuals with autism would show normative reactivity to emotion in familiar people.
Methods: Participants were 21 children with autism and 21 children with typical development, aged two to five years, matched on age and gender. The children observed videos of familiar people (their child-care teachers) and unfamiliar people expressing fear, whilst their visual attention and pupillary reactions were recorded (the latter as an index of emotional reactivity), using eye tracking technology.
Results: The children with autism showed normative pupillary reactions (peak magnitude) to fear expressed by familiar people, but a reduced response to fear expressed by unfamiliar people. However, across familiarity conditions, the children with autism had longer latency peak responses than the typically developing children. This pattern of findings was independent of cognitive factors or visual attention as visual attention by group was not related to familiarity condition. The children with autism had reduced visual attention to neutral faces; however, on fearful faces there were no group differences. Abnormalities in pupillary reactivity in the autism group were related to less prosocial behaviour and more severe play and communication deficits.
Conclusions: Children with autism were less atypical in their responses to fearful expressions of people they know, arguing against a pervasive emotional impairment in autism, but rather one that may be mediated by familiarity.
C1 [Nuske, Heather J.; Vivanti, Giacomo; Dissanayake, Cheryl] La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Melbourne, Vic, Australia.
[Vivanti, Giacomo] La Trobe Univ, Victoria Autism Specif Early Learning & Care Ctr, Melbourne, Vic, Australia.
RP Dissanayake, C (reprint author), La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Melbourne, Vic, Australia.
EM c.dissanayake@latrobe.edu.au
CR ADOLPHS R, 1995, J NEUROSCI, V15, P5879
ADOLPHS R, 1994, NATURE, V372, P669, DOI 10.1038/372669a0
Akechi H, 2009, CHILD DEV, V80, P1134, DOI 10.1111/j.1467-8624.2009.01321.x
Anderson CJ, 2006, J CLIN EXP NEUROPSYC, V28, P1238, DOI 10.1080/13803390500376790
APA, 2013, DSM 5 DIAGN STAT MAN
APPLEGATE CD, 1983, PHYSIOL BEHAV, V31, P353, DOI 10.1016/0031-9384(83)90201-9
Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
Aylward E, 2004, STAART CPEA STUD ADV, V17, P20
Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
Beatty J., 2000, HDB PSYCHOPHYSIOLOGY, P142
Beaupre MG, 2006, PERS SOC PSYCHOL B, V32, P16, DOI 10.1177/0146167205277097
Blair RJR, 1999, PERS INDIV DIFFER, V26, P477, DOI 10.1016/S0191-8869(98)00154-8
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Bradley MM, 2008, PSYCHOPHYSIOLOGY, V45, P602, DOI 10.1111/j.1469-8986.2008.00654.x
BUSHNELL IWR, 1989, BRIT J DEV PSYCHOL, V7, P3
CAPPS L, 1994, DEV PSYCHOPATHOL, V6, P249, DOI 10.1017/S0954579400004569
Carver LJ, 2003, DEV PSYCHOBIOL, V42, P148, DOI 10.1002/dev.10078
Chau M., 2005, REAL TIME EYE TRACKI
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
DAVIS M, 1992, ANNU REV NEUROSCI, V15, P353, DOI 10.1146/annurev.ne.15.030192.002033
Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x
Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
deHaan M, 1997, CHILD DEV, V68, P187, DOI 10.2307/1131845
de Haan M, 1999, DEV PSYCHOL, V35, P1113, DOI 10.1037/0012-1649.35.4.1113
Dissanayake C, 1996, J CHILD PSYCHOL PSYC, V37, P149, DOI 10.1111/j.1469-7610.1996.tb01386.x
EKMAN P, 1983, SCIENCE, V221, P1208, DOI 10.1126/science.6612338
Elfenbein HA, 2003, J PERS SOC PSYCHOL, V85, P276, DOI 10.1037/0022-3514.85.2.276
ESTEVES F, 1993, SCAND J PSYCHOL, V34, P1, DOI 10.1111/j.1467-9450.1993.tb01096.x
Falck-Ytter T, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-28
Falck-Ytter T, 2008, AUTISM RES, V1, P297, DOI 10.1002/aur.45
FIELD TM, 1984, INFANT BEHAV DEV, V7, P19, DOI 10.1016/S0163-6383(84)80019-3
Fox SE, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00089
Gallo DP, 2010, DIAGNOSING AUTISM SP, P105
Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006
Gobbini MI, 2007, NEUROPSYCHOLOGIA, V45, P32, DOI 10.1016/j.neuropsychologia.2006.04.015
Graur S, 2013, CURR NEUROL NEUROSCI, V13, DOI 10.1007/s11910-013-0365-0
Greimel E, 2010, NEUROIMAGE, V49, P1055, DOI 10.1016/j.neuroimage.2009.07.057
Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
Herrmann E, 2013, J COMP PSYCHOL, V127, P63, DOI 10.1037/a0028929
Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020
Hudry K, 2009, RES AUTISM SPECT DIS, V3, P74, DOI 10.1016/j.rasd.2008.04.004
Hume K, 2012, J AUTISM DEV DISORD, V42, P2084, DOI 10.1007/s10803-012-1457-4
Huynh CM, 2010, J VIS, V10, P628
Janisse M.P., 1977, PUPILLOMETRY PSYCHOL
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Joseph R, 2011, NEUROPSYCHOLOGY AUTI, P281
Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
Kahana-Kalman R, 2001, CHILD DEV, V72, P352, DOI 10.1111/1467-8624.00283
KASARI C, 1993, DEV PSYCHOPATHOL, V5, P403, DOI 10.1017/S0954579400004491
Key APF, 2012, DEV COGN NEUROS-NETH, V2, P244, DOI 10.1016/j.dcn.2011.12.003
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Komogortsev OV, 2010, IEEE T BIO-MED ENG, V57, P2635, DOI 10.1109/TBME.2010.2057429
Korpilahti P, 2007, J AUTISM DEV DISORD, V37, P1539, DOI 10.1007/s10803-006-0271-2
Kuchinke L, 2011, NEUROPSYCHOLOGIA, V49, P331, DOI 10.1016/j.neuropsychologia.2010.12.026
Kylliainen A, 2012, J CHILD PSYCHOL PSYC, V53, P790, DOI 10.1111/j.1469-7610.2011.02522.x
Lang P., 1980, SELF ASSESSMENT MANI
LeDoux J., 1996, EMOTIONAL BRAIN
Lense M., 2011, AUTISM SPECTRUM DISO
Lerner MD, 2013, DEV COGN NEUROS-NETH, V3, P11, DOI 10.1016/j.dcn.2012.08.005
Loewenfeld I, 1993, PUPIL ANATOMY PHYSL
Lord C., 1999, AUTISM DIAGNOSTIC OB
MACDONALD NE, 1978, DEV PSYCHOL, V14, P235, DOI 10.1037//0012-1649.14.3.235
Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
Martineau J, 2011, J PSYCHIATR RES, V45, P1077, DOI 10.1016/j.jpsychires.2011.01.008
Mehler MF, 2009, BRAIN RES REV, V59, P388, DOI 10.1016/j.brainresrev.2008.11.001
Minagawa-Kawai Y, 2009, CEREB CORTEX, V19, P284, DOI 10.1093/cercor/bhn081
MINSHEW NJ, 1995, NEUROPSYCHOLOGY, V9, P255, DOI 10.1037//0894-4105.9.2.255
Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085
Montague DPF, 2002, CHILD DEV, V73, P1339, DOI 10.1111/1467-8624.00475
Moulson MC, 2009, CHILD DEV, V80, P1039, DOI 10.1111/j.1467-8624.2009.01315.x
Mullen E, 1995, MULLEN SCALES EARLY
Nadel J., 2000, AUTISM, V4, P133, DOI DOI 10.1177/1362361300004002003
Nakagawa S, 2004, BEHAV ECOL, V15, P1044, DOI 10.1093/beheco/arh107
Nakato E, 2011, EARLY HUM DEV, V87, P1, DOI 10.1016/j.earlhumdev.2010.08.030
Natu V, 2011, BRIT J PSYCHOL, V102, P726, DOI 10.1111/j.2044-8295.2011.02053.x
Nuske HJ, 2014, J AUTISM DEV DISORD
Nuske HJ, 2013, COGNITION EMOTION, V27, P1042, DOI 10.1080/02699931.2012.762900
Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
Ogai Masahiro, 2003, Neuroreport, V14, P559, DOI 10.1097/00001756-200303240-00006
Partala T, 2003, INT J HUM-COMPUT ST, V59, P185, DOI 10.1016/S1071-5819(03)00017-X
Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Perneger TV, 1998, BRIT MED J, V316, P1236
Pierce K, 2008, BIOL PSYCHIAT, V64, P552, DOI 10.1016/j.biopsych.2008.05.013
Pierce K, 2004, BRAIN, V127, P2703, DOI 10.1093/brain/awh289
Poole A., 2006, ENCY HUMAN COMPUTER, P211, DOI DOI 10.4018/978-1-59140-562-7.CH034
Powers N., 2009, COMMUNICATIVE MUSICA, P209
Preston SD, 2002, BEHAV BRAIN SCI, V25, P1
Rajkowski J., 1993, Society for Neuroscience Abstracts, V19, P974
Riby DM, 2012, J CLIN EXP NEUROPSYC, V34, P385, DOI 10.1080/13803395.2011.645019
Rieffe C, 2010, PERS INDIV DIFFER, V49, P362, DOI 10.1016/j.paid.2010.03.046
Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
Schmidt MFH, 2012, COGNITION, V124, P325, DOI 10.1016/j.cognition.2012.06.004
Sepeta L, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-17
SIGMAN M, 1984, J AUTISM DEV DISORD, V14, P231, DOI 10.1007/BF02409576
Sterling L, 2008, J AUTISM DEV DISORD, V38, P1666, DOI 10.1007/s10803-008-0550-1
Stern R. M., 2001, PSYCHOPHYSIOLOGICAL
STINSON L, 1992, J PERS SOC PSYCHOL, V62, P787, DOI 10.1037//0022-3514.62.5.787
Takeuchi Y, 2013, ENCY AUTISM SPECTRUM, P2053
Todd RM, 2008, NEUROPSYCHOLOGIA, V46, P595, DOI 10.1016/j.neuropsychologia.2007.10.011
Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
Trepagnier C, 2002, CYBERPSYCHOL BEHAV, V5, P213, DOI 10.1089/109493102760147204
TYSZKA JM, 2013, CEREB CORTEX
Urry HL, 2006, J NEUROSCI, V26, P4415, DOI 10.1523/JNEUROSCI.3215-05.2006
URSIN H, 1960, ELECTROEN CLIN NEURO, V12, P1, DOI 10.1016/0013-4694(60)90058-4
Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
Wagner JB, 2013, J AUTISM DEV DISORD, V43, P188, DOI 10.1007/s10803-012-1565-1
Walker-Andrews AS, 2011, EMOTION, V11, P842, DOI 10.1037/a0024435
WALTON GE, 1992, INFANT BEHAV DEV, V15, P265, DOI 10.1016/0163-6383(92)80027-R
Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x
Wicker B, 2008, SOC COGN AFFECT NEUR, V3, P135, DOI 10.1093/scan/nsn007
Winkielman P, 2009, EMOT REV, V1, P178, DOI 10.1177/1754073908100442
Zbrozyna A. W., 1963, PROGRESS BRAIN RESEA, V3, P50, DOI 10.1016/S0079-6123(08)60566-X
NR 119
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD MAY 31
PY 2014
VL 6
AR 14
DI 10.1186/1866-1955-6-14
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AK5MO
UT WOS:000338469000001
PM 24982695
ER
PT J
AU Caulfield, F
Ewing, L
Burton, N
Avard, E
Rhodes, G
AF Caulfield, Frances
Ewing, Louise
Burton, Nichola
Avard, Eleni
Rhodes, Gillian
TI Facial Trustworthiness Judgments in Children with ASD Are Modulated by
Happy and Angry Emotional Cues
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; ASPERGER-SYNDROME; SOCIAL COGNITION; FACES;
EXPRESSIONS; BEHAVIOR; IMPRESSIONS; AMYGDALA; BRAIN; ATTRACTIVENESS
AB Appearance-based trustworthiness inferences may reflect the misinterpretation of emotional expression cues. Children and adults typically perceive faces that look happy to be relatively trustworthy and those that look angry to be relatively untrustworthy. Given reports of atypical expression perception in children with Autism Spectrum Disorder (ASD), the current study aimed to determine whether the modulation of trustworthiness judgments by emotional expression cues in children with ASD is also atypical. Cognitively-able children with and without ASD, aged 6-12 years, rated the trustworthiness of faces showing happy, angry and neutral expressions. Trust judgments in children with ASD were significantly modulated by overt happy and angry expressions, like those of typically-developing children. Furthermore, subtle emotion cues in neutral faces also influenced trust ratings of the children in both groups. These findings support a powerful influence of emotion cues on perceived trustworthiness, which even extends to children with social cognitive impairments.
C1 [Caulfield, Frances; Ewing, Louise; Burton, Nichola; Avard, Eleni; Rhodes, Gillian] Univ Western Australia, Sch Psychol, Australian Res Council, Ctr Excellence Cognit & Its Disorders, Perth, WA 6009, Australia.
RP Ewing, L (reprint author), Univ Western Australia, Sch Psychol, Australian Res Council, Ctr Excellence Cognit & Its Disorders, Perth, WA 6009, Australia.
EM louise.ewing@uwa.edu.au
RI Ewing, Louise/H-9158-2014
FU Australian Research Council Centre of Excellence in Cognition and its
Disorders [CE110001021]; ARC Professional Fellowship [DP0877379]; ARC
Discovery Outstanding Researcher Award [DP130102300]
FX This research was supported by the Australian Research Council Centre of
Excellence in Cognition and its Disorders (CE110001021), an ARC
Professional Fellowship to Rhodes (DP0877379) and an ARC Discovery
Outstanding Researcher Award to Rhodes (DP130102300). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Adolphs R, 1998, NATURE, V393, P470, DOI 10.1038/30982
Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
Caulfield F, 2014, JUDGING TRUSTW UNPUB
Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
Chang LJ, 2010, COGNITIVE PSYCHOL, V61, P87, DOI 10.1016/j.cogpsych.2010.03.001
Cooper PA, 2006, DEVELOPMENTAL SCI, V9, P530, DOI 10.1111/j.1467-7687.2006.00520.x
Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
Cosmides L., 1992, ADAPTED MIND EVOLUTI, P163
Couture SM, 2010, PSYCHOL MED, V40, P569, DOI 10.1017/S003329170999078X
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
DAVIES S, 1994, J CHILD PSYCHOL PSYC, V35, P1033, DOI 10.1111/j.1469-7610.1994.tb01808.x
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Evers K, 2014, AUTISM RES TREATMENT, V2014, P1
Field A., 2009, DISCOVERING STAT USI
Franklin RG, 2013, J NONVERBAL BEHAV, V37, P139, DOI 10.1007/s10919-013-0150-4
Frith Uta, 2008, AUTISM VERY SHORT IN
Gaigg SB, 2012, FRONTIERS INTEGRATIV, V6
Gao XQ, 2009, J EXP CHILD PSYCHOL, V102, P503, DOI 10.1016/j.jecp.2008.11.002
Gao XQ, 2010, J EXP CHILD PSYCHOL, V107, P67, DOI 10.1016/j.jecp.2010.05.003
Hamilton AFDC, 2007, CURR BIOL, V17, pR641, DOI 10.1016/j.cub.2007.06.009
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Hassin R, 2000, J PERS SOC PSYCHOL, V78, P837, DOI 10.1037//0022-3514.78.5.837
Haynes S, 2011, JUDGMENTS TRUSTWORTH
Hirschfeld L, 2007, CURR BIOL, V17, pR451, DOI 10.1016/j.cub.2007.04.051
HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Lacroix A, 2009, RES DEV DISABIL, V30, P976, DOI 10.1016/j.ridd.2009.02.002
Lord C., 2012, AUTISM DIAGNOSTIC 1
Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
Mathersul D, 2013, INT J PSYCHOPHYSIOL, V87, P88, DOI 10.1016/j.ijpsycho.2012.11.005
MCARTHUR LZ, 1983, PSYCHOL REV, V90, P215, DOI 10.1037//0033-295X.90.3.215
Nuske HJ, 2013, COGNITION EMOTION, V27, P1042, DOI 10.1080/02699931.2012.762900
Oosterhof NN, 2008, P NATL ACAD SCI USA, V105, P11087, DOI 10.1073/pnas.0805664105
Oosterhof NN, 2009, EMOTION, V9, P128, DOI 10.1037/a0014520
Pellicano E, 2014, CAMBRIDGE FACE UNPUB
Piggot J, 2004, J AM ACAD CHILD PSY, V43, P473, DOI 10.1097/01.chi.0000111363.94169.37
Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
Ramachandran R, 2009, J CHILD PSYCHOL PSYC, V50, P871, DOI 10.1111/j.1469-7610.2009.02053.x
Rhodes G, 2005, EVOL HUM BEHAV, V26, P186, DOI 10.1016/j.evolhumbehav.2004.08.014
Rotenberg KJ, 2005, BRIT J DEV PSYCHOL, V23, P271, DOI 10.1348/026151005X26192
Rotenberg KJ, 1994, J SOC CLIN PSYCHOL, V13, P152, DOI DOI 10.1521/JSCP.1994.13.2.152
Rule NO, 2008, PSYCHOL SCI, V19, P109, DOI 10.1111/j.1467-9280.2008.02054.x
Rule NO, 2013, J PERS SOC PSYCHOL, V104, P409, DOI 10.1037/a0031050
Rutter M., 2003, SOCIAL COMMUNICATION
Said CP, 2009, EMOTION, V9, P260, DOI 10.1037/a0014681
Secord P. F., 1958, PERSON PERCEPTION IN, P300
SILVER NC, 1987, J APPL PSYCHOL, V72, P146, DOI 10.1037/0021-9010.72.1.146
Skinner AL, 2010, PSYCHOL SCI, V21, P1248, DOI 10.1177/0956797610380702
Sutherland CAM, 2013, COGNITION, V127, P105, DOI 10.1016/j.cognition.2012.12.001
Todorov A, 2009, SOC COGNITION, V27, P813
Uljarevic M, 2013, J AUTISM DEV DISORD, V43, P1
Webb S. J., 2011, OXFORD HDB FACE PERC, P839
Wechsler D, 1999, WECHSLER ABBREVIATED
White S, 2006, BRAIN COGNITION, V61, P69, DOI 10.1016/j.bande.2005.12.007
Willis J, 2006, PSYCHOL SCI, V17, P592, DOI 10.1111/j.1467-9280.2006.01750.x
Winston JS, 2002, NAT NEUROSCI, V5, P277, DOI 10.1038/nn816
Zebrowitz L., 2008, SOCIAL PERSONALITY P, V2, P1497, DOI DOI 10.1111/J.1751-9004.2008.00109.X
Zebrowitz L A, 1997, Pers Soc Psychol Rev, V1, P204, DOI 10.1207/s15327957pspr0103_2
Zebrowitz LA, 2007, PERS SOC PSYCHOL B, V33, P648, DOI 10.1177/0146167206297399
NR 65
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 30
PY 2014
VL 9
IS 5
AR e97644
DI 10.1371/journal.pone.0097644
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK0KM
UT WOS:000338101500020
PM 24878763
ER
PT J
AU Larson, E
Miller-Bishoff, T
AF Larson, Elizabeth
Miller-Bishoff, Thomas
TI Family routines within the ecological niche: an analysis of the
psychological well-being of US caregivers of children with disabilities
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE developmental disability; family; routines; psychological well-being;
parenting; eco-cultural niche
ID AUTISM SPECTRUM DISORDER; MENTAL-HEALTH; RITUALS; MOTHERS; CONTEXT;
PERSPECTIVES; EMPLOYMENT; ETHNICITY; HAPPINESS; PARENTS
AB Using mixed methods, this study examined the relationship of caregivers of children with disabilities' psychological well-being (PM) and their orchestration of daily routines within their ecological niche. Thirty-nine U.S. caregivers completed in-depth interviews, PWB Scales, and Family Time and Routines Index (FTRI). We used a multi-step analysis. Interview data was coded and vignettes created without knowledge of PWB and FTRI ratings. Next, the relationship of quantitative measures was analyzed. Four groups were created using FTRI-extent and PWB means: (1) low routine-low PWB, (2) low routine-high PWB, (3) high routine-low PWB, and (4) high routine-high PWB. We examined qualitative differences in key features between groups. Findings: Total PWB and FTRI scores were not significantly correlated, PWB Purpose in Life and FTRI-extent scores were moderately positively correlated, and PWB Environmental Mastery and FTRI-extent correlation approached significance. Qualitative findings describe caregivers' structuring of routines, intensity of oversight, support in routines, management of dinner, paid work, and needs for respite. The four groups differed in paid work, household support, degree the child could self-occupy, Environmental Mastery, and opportunities to recuperate. Caregivers with higher levels of well-being and more regular routines did paid work, had supportive spouses, had children who more often could follow routines, had higher Environmental Mastery, could orchestrate a family meal, and had breaks from care in either work or leisure. All Native American caregivers and Mexican American caregivers with spouses were in the high routine-high PWB group. Insight into this complex negotiation between family members within daily routines may provide practitioners a better understanding of how to work within family circles to foster therapeutic alliances, identify focused intervention targets, and promote positive family wide outcomes.
C1 [Larson, Elizabeth; Miller-Bishoff, Thomas] Univ Wisconsin, Dept Kinesiol, Occupat Therapy Program, Madison, WI 53706 USA.
RP Larson, E (reprint author), Univ Wisconsin, Dept Kinesiol, Occupat Therapy Program, Med Sci Ctr 2180, 1300 Univ Ave, Madison, WI 53706 USA.
EM blarson@education.wisc.edu
CR Anderson D, 2007, PUBLIC HEALTH REP, V122, P3
Anderson PM, 2012, ECON HUM BIOL, V10, P340, DOI 10.1016/j.ehb.2012.04.006
Bernheimer LP, 2007, INFANT YOUNG CHILD, V20, P192
BIRENBAU.A, 1971, J HEALTH SOC BEHAV, V12, P55, DOI 10.2307/2948454
Bourdieu P., 1990, LOGIC PRACTICE
BRONFENBRENNER U, 1986, DEV PSYCHOL, V22, P723, DOI 10.1037//0012-1649.22.6.723
Cheslock M. A., 2001, ASHA LEADER, V16, P10
Christensen P, 2004, SOC SCI MED, V59, P377, DOI 10.1016/j.socscimed.2003.10.021
Crespo C, 2013, INT J PSYCHOL, V48, P729, DOI 10.1080/00207594.2013.806811
Curran AL, 2001, DEV MED CHILD NEUROL, V43, P529, DOI 10.1017/S0012162201000962
Denzin N. K., 2013, STRATEGIES QUALITATI, P169
Desai MU, 2012, TRANSCULT PSYCHIATRY, V49, P613, DOI 10.1177/1363461512447139
Dunst C. J., 2000, J EARLY INTERVENTION, V23, P151, DOI 10.1177/10538151000230030501
Eisenhower A, 2006, J INTELL DISABIL RES, V50, P905, DOI 10.1111/j.1365-2788.2006.00913.x
Fiese BH, 2007, OTJR-OCCUP PART HEAL, V27, p41S
Fiese BH, 2013, PEDIATRICS, V132, P552, DOI 10.1542/peds.2013-0349
Fiese BH, 2002, J FAM PSYCHOL, V16, P381, DOI 10.1037//0893-3200.16.4.381
Fruh S. M., 2011, J NURSE PRACTITIONER, V7, P18, DOI 10.1016/j.nurpra.2010.04.017
GALLIMORE R, 1989, AM J MENT RETARD, V94, P216
Gannotti M, 2013, J DEV PHYS DISABIL, V25, P419, DOI 10.1007/s10882-012-9318-9
Gibbs N., 2006, TIME MAGAZINE
Gibson-Davis CM, 2010, DEV PSYCHOL, V46, P151, DOI 10.1037/a0017410
Higley L., 1984, FAMILIES HANDICAPPED
Hoogsteen L, 2013, J PEDIATR NURS, V28, P135, DOI 10.1016/j.pedn.2012.06.002
Huang Y. P., 2011, J CLIN NURS, V21, P189, DOI [10.1111/j.1365-2702.2011.03741.x, DOI 10.1111/J.1365-2702.2011.03741.X]
Hyde JS, 2004, CHILD DEV, V75, P580, DOI 10.1111/j.1467-8624.2004.00694.x
Larson E. A., 2006, OTJR-OCCUP PART HEAL, V26, P1
Larson E. A., 1996, THESIS U SO CALIFORN
Liptak Gregory S, 2006, J Pediatr Health Care, V20, P245, DOI 10.1016/j.pedhc.2005.12.008
Lucyshyn JM, 2004, RES PRACT PERS SEV D, V29, P104, DOI 10.2511/rpsd.29.2.104
Lucyshyn JM, 2007, J POSIT BEHAV INTERV, V9, P131, DOI 10.1177/10983007070090030201
Maul CA, 2009, TOP EARLY CHILD SPEC, V29, P155, DOI 10.1177/0271121408328516
McCubbin H. I., 1996, FAMILY ASSESSMENT RE, P325
McCubbin HI, 1996, FAMILY ASSESSMENT RE
Murphy NA, 2007, CHILD CARE HLTH DEV, V33, P180, DOI 10.1111/j.1365-2214.2006.00644.x
Myers BJ, 2009, RES AUTISM SPECT DIS, V3, P670, DOI 10.1016/j.rasd.2009.01.004
National Health Interview Survey (NHIS), 1999, DIV HLTH INT STAT
O'Brien V. J., 2004, THESIS U SO CALIFORN
Olsson MB, 2006, J INTELL DISABIL RES, V50, P963, DOI 10.1111/j.1365-2788.2006.00930.x
Richards M. H., 1994, DIVERGENT REALITIES
Roberts J., 1984, FAMILY THER COLLECT, V11, P1
Rodger S, 2011, BRIT J OCCUP THER, V74, P20, DOI 10.4276/030802211X12947686093567
Rupp K., 2005, SOCIAL SECURITY B, V66, P21
Ryan RM, 2001, ANNU REV PSYCHOL, V52, P141, DOI 10.1146/annurev.psych.52.1.141
RYFF CD, 1989, J PERS SOC PSYCHOL, V57, P1069, DOI 10.1037/0022-3514.57.6.1069
Sawyer MG, 2010, J AUTISM DEV DISORD, V40, P620, DOI 10.1007/s10803-009-0912-3
Schaaf RC, 2011, AUTISM, V15, P373, DOI 10.1177/1362361310386505
Schroeder SA, 2007, NEW ENGL J MED, V357, P1221, DOI 10.1056/NEJMsa073350
Sheldon KM, 2006, J PERS SOC PSYCHOL, V91, P331, DOI 10.1037/0022-3514.91.2.331
Spagnola M, 2007, INFANT YOUNG CHILD, V20, P284
Thyen U, 1999, PEDIATRICS, V103, P1235, DOI 10.1542/peds.103.6.1235
Warfield M. J., 2001, MENT RETARD, V19, P297, DOI [10.1352/0047-6765(2001)039<0297:EPAWBA>2.0.CO;2, DOI 10.1352/0047-6765(2001)039<0297:EPAWBA>2.0.C0;2]
Weisner TS, 2005, INT CULT PSYCHOL, P41, DOI 10.1007/0-387-27550-9_3
Weisner TS, 1997, ETHOS, V25, P177, DOI 10.1525/eth.1997.25.2.177
NR 54
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 30
PY 2014
VL 5
AR 495
DI 10.3389/fpsyg.2014.00495
PG 14
WC Psychology, Multidisciplinary
SC Psychology
GA AJ3CD
UT WOS:000337541800001
PM 24910625
ER
PT J
AU Dvash, J
Ben-Zeev, A
Noga, A
Shamay-Tsoory, S
AF Dvash, Jonathan
Ben-Zeev, Aaron
Noga, Adler
Shamay-Tsoory, Simone
TI The road not taken: Social vs. private comparisons in Asperger's
syndrome and high functioning autism
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Social comparison; Autism; Counterfactual thinking; Emotion; Reward
processing
ID COUNTERFACTUAL THINKING; SPECTRUM DISORDERS; JOINT ATTENTION;
YOUNG-CHILDREN; EMOTIONS; OTHERS; BRAIN; MIND; DYSFUNCTION; IMPAIRMENT
AB Evaluation of the outcomes of our decisions may instigate comparisons of our actual outcome with those of others (social comparisons) or comparisons with alternative outcomes of choices not made (private comparisons). Previous research has suggested a deficit in attention to social information among individuals with autism spectrum disorders. As social comparison involves the processing of social information, here we investigated the orientation towards and sensitivity to social vs. private comparisons in individuals with autism spectrum disorders. We compared the sensitivity to social vs. private comparisons among individuals diagnosed with Asperger's Syndrome (AS) or High Functioning Autism, using a task that entailed monetary rewards. Results showed that while individuals with AS generally demonstrate comparable sensitivity to absolute and relative rewards, they show less sensitivity to social comparison as compared to controls. Furthermore, they are characterized by a higher sensitivity to private rather than social comparison. These results suggest that low sensitivity to social comparisons is an important factor to consider in autism spectrum disorders. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Dvash, Jonathan; Ben-Zeev, Aaron; Noga, Adler; Shamay-Tsoory, Simone] Bar Ilan Univ, Sch Educ, IL-59200 Ramat Gan, Israel.
RP Shamay-Tsoory, S (reprint author), Bar Ilan Univ, Sch Educ, IL-59200 Ramat Gan, Israel.
EM sshamay@psy.haifa.ac.il
CR ADAMS JS, 1963, J ABNORM PSYCHOL, V67, P422, DOI 10.1037/h0040968
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bacon AL, 1998, J AUTISM DEV DISORD, V28, P129, DOI 10.1023/A:1026040615628
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Bault N, 2011, P NATL ACAD SCI USA, V108, P16044, DOI 10.1073/pnas.1100892108
Bauminger N, 2008, COGNITION EMOTION, V22, P595, DOI 10.1080/02699930701439986
Bauminger N, 2004, DEV PSYCHOPATHOL, V16, P157, DOI 10.1017/S0954579404044451
Channon S, 2001, J AUTISM DEV DISORD, V31, P461, DOI 10.1023/A:1012212824307
Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
Coricelli G, 2010, PHILOS T R SOC B, V365, P241, DOI 10.1098/rstb.2009.0159
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
Dawson G, 2002, CHILD DEV, V73, P345, DOI 10.1111/1467-8624.00411
De Martino B, 2008, J NEUROSCI, V28, P10746, DOI 10.1523/JNEUROSCI.2895-08.2008
Dvash J, 2010, HUM BRAIN MAPP, V31, P1741, DOI 10.1002/hbm.20972
FEINMAN S, 1982, MERRILL PALMER QUART, V28, P445
Festinger L, 1954, HUM RELAT, V7, P117, DOI 10.1177/001872675400700202
Festinger L., 1954, HUM RELAT, V7, P17
Fliessbach K, 2007, SCIENCE, V318, P1305, DOI 10.1126/science.1145876
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Harris P. L, 1989, DEV PSYCHOPATHOL, V1, P191, DOI 10.1017/S0954579400000389
Haznedar MM, 2000, AM J PSYCHIAT, V157, P1994, DOI 10.1176/appi.ajp.157.12.1994
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Homans George C, 1961, SOCIAL BEHAV ITS ELE
Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
Izuma K, 2011, P NATL ACAD SCI USA, V108, P17302, DOI 10.1073/pnas.1107038108
Johnson SA, 2006, J INT NEUROPSYCH SOC, V12, P668, DOI 10.1017/S1355617706060802
Kemper TL, 2002, MOL PSYCHIATR, V7, pS12, DOI 10.1038/sj.mp.4001165
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Legerstee M, 1998, CHILD DEV, V69, P37, DOI 10.2307/1132068
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
MARKMAN KD, 1993, J EXP SOC PSYCHOL, V29, P87, DOI 10.1006/jesp.1993.1005
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P288, DOI 10.1016/j.rasd.2007.07.003
Moran JM, 2011, P NATL ACAD SCI USA, V108, P2688, DOI 10.1073/pnas.1011734108
O'Connor K, 2008, J AUTISM DEV DISORD, V38, P1989, DOI 10.1007/s10803-008-0559-5
Roese NJ, 1997, PSYCHOL BULL, V121, P133, DOI 10.1037/0033-2909.121.1.133
Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
Sault N., 2008, PLOS ONE, V3, P10
Fehr E, 1999, Q J ECON, V114, P817, DOI 10.1162/003355399556151
Schneider K, 2013, SOC COGN AFFECT NEUR, V8, P702, DOI 10.1093/scan/nss051
SHALLICE T, 1978, CORTEX, V14, P294
Shamay-Tsoory SG, 2008, J AUTISM DEV DISORD, V38, P1451, DOI 10.1007/s10803-007-0515-9
Shipley WC, 1940, J PSYCHOL, V9, P371
SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
South M, 2011, J AUTISM DEV DISORD, V41, P55, DOI 10.1007/s10803-010-1021-z
Stouffer SA, 1949, AM SOLDIER, V1
Tomasello M, 2001, J CROSS CULT PSYCHOL, V32, P135, DOI 10.1177/0022022101032002002
Torralva T., 2012, RES DEV DISABIL, V34, P817
Zachary R. A., 1986, SHIPLEY I LIVING SCA
Zilbovicius M, 2000, AM J PSYCHIAT, V157, P1988, DOI 10.1176/appi.ajp.157.12.1988
NR 51
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY 30
PY 2014
VL 216
IS 3
BP 385
EP 390
DI 10.1016/j.psychres.2014.01.036
PG 6
WC Psychiatry
SC Psychiatry
GA AH4PF
UT WOS:000336109800014
PM 24629710
ER
PT J
AU Chomiak, T
Hung, J
Cihal, A
Dhaliwal, J
Baghdadwala, MI
Dzwonek, A
Podgorny, P
Hu, B
AF Chomiak, T.
Hung, J.
Cihal, A.
Dhaliwal, J.
Baghdadwala, M. I.
Dzwonek, A.
Podgorny, P.
Hu, B.
TI AUDITORY-CUED SENSORIMOTOR TASK REVEALS DISENGAGEMENT DEFICITS IN RATS
EXPOSED TO THE AUTISM-ASSOCIATED TERATOGEN VALPROIC ACID
SO NEUROSCIENCE
LA English
DT Article
DE autism; disengagement; temporal lobe; valproic acid; attention; savant
ID TEMPORAL CORTEX; SPECTRUM DISORDERS; NEURAL MECHANISMS;
VISUAL-ATTENTION; ANIMAL-MODEL; MEMORY; CHILDREN; PROJECTIONS;
MODULATION; THALAMUS
AB Autism Spectrum Disorder (ASD) is often found to co-exist with non-core behavioral manifestations that include difficulties in disengagement of attention to sensory cues. Here we examined whether this behavioral abnormality can be induced in rats prenatally exposed to valproic acid (VPA), a well-established teratogen associated with ASD animal models. We tested rats using an auditory-cued sensorimotor task (ACST) based on the premise that ACST will be more sensitive to developmental changes in temporal association cortex (TeA) of the posterior attention system. We show that VPA rats learned the ACST markedly faster than control animals, but they exhibited a profound preoccupation with cues associated with the expectancy at the reward location such that disengagement was disrupted. Control rats on the other hand were able to disengage and utilize auditory cues for re-engagement. However, both control and VPA-treated rats performed similarly when tested on novel object recognition (NOR) and novel context mismatch (NOCM) behavioral tasks that are known to be sensitive to normal perirhinal and prefrontal network functioning respectively. Consistent with disrupted posterior rather than frontal networks, we also report that VPA can selectively act on deep-layer TeA cortical neurons by showing that VPA increased dendritic density in isolated deep-layer TeA but not frontal neurons. These results describe a useful approach to examine the role of cue-dependent control of attention systems in rodent models of autism and suggest that disengagement impairments may arise from an inability to modify behavior through the appropriate use of sensory cue associations. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Chomiak, T.; Hung, J.; Cihal, A.; Dhaliwal, J.; Baghdadwala, M. I.; Dzwonek, A.; Podgorny, P.; Hu, B.] Univ Calgary, Fac Med, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada.
RP Chomiak, T (reprint author), 3280 Hosp Dr NW, Calgary, AB, Canada.
EM tgchomia@ucalgary.ca; hub@ucalgary.ca
FU Canadian Institutes of Health Research, Canada; CIHR Regenerative
Medicine Initiative, Canada; NSERC, Canada; Killam Trusts; Sinneave
Family Foundation
FX This study was supported by grants to B. H. from Canadian Institutes of
Health Research, Canada; CIHR Regenerative Medicine Initiative, Canada;
and training grants from NSERC, Canada; and Killam Trusts. TC was
previously supported by a fellowship from Sinneave Family Foundation. We
would also like to thank Dr. Minh Dang Nguyen's lab and Dr. Laura Craig
for technical assistance.
CR Allen G, 2001, FRONT BIOSCI-LANDMRK, V6, pD105, DOI 10.2741/allen
Amaral DG, 2000, PRINCIPLES NEURAL SC, P317
Banerjee A, 2013, INT J NEUROPSYCHOPH, V16, P1309, DOI 10.1017/S1461145712001216
Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
BERRY M, 1965, J ANAT, V99, P691
Bromley RL, 2013, J NEUROL NEUROSUR PS, V84, P637, DOI 10.1136/jnnp-2012-304270
BRUCKNER G, 1976, J COMP NEUROL, V166, P245, DOI 10.1002/cne.901660208
Bryson SE, 2005, NEUROBIOLOGY AUTISM, P34
Bussey TJ, 1999, J NEUROSCI, V19, P495
CASEY BJ, 1993, J CLIN EXP NEUROPSYC, V15, P933, DOI 10.1080/01688639308402609
CHELAZZI L, 1993, NATURE, V363, P345, DOI 10.1038/363345a0
Chomiak T, 2013, NEUROTOXICOL TERATOL, V36, P57, DOI 10.1016/j.ntt.2012.08.005
Chomiak T, 2010, BMC NEUROSCI, V11, DOI 10.1186/1471-2202-11-102
Chomiak T, 2008, J NEUROPHYSIOL, V100, P327, DOI 10.1152/jn.90392.2008
Chomiak T, 2013, PATHOLOG RES INT, V2013
Christensen J, 2013, JAMA-J AM MED ASSOC, V309, P1696, DOI 10.1001/jama.2013.2270
Coleman M, 2005, NEUROLOGY AUTISM, P3
Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755
DESIMONE R, 1995, ANNU REV NEUROSCI, V18, P193, DOI 10.1146/annurev.ne.18.030195.001205
De Weerd P, 1999, NAT NEUROSCI, V2, P753, DOI 10.1038/11234
Edalatmanesh MA, 2013, BRAIN RES, V1526, P15, DOI 10.1016/j.brainres.2013.06.024
Favre MR, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00088
Fuster JM, 1997, TRENDS NEUROSCI, V20, P451, DOI 10.1016/S0166-2236(97)01128-4
Gilbert CD, 2007, NEURON, V54, P677, DOI 10.1016/j.neuron.2007.05.019
Hu B, 2003, EXP BRAIN RES, V153, P543, DOI 10.1007/s00221-003-1611-5
Hutsler JJ, 2010, BRAIN RES, V1309, P83, DOI 10.1016/j.brainres.2009.09.120
Johnsrude IS, 2000, J NEUROSCI, V20, P2649
Kanner L, 1943, NERV CHILD, V2, P217
Kimura A, 2003, NEUROSCIENCE, V117, P1003, DOI 10.1016/S0306-4522(02)00949-1
Kincade JM, 2005, J NEUROSCI, V25, P4593, DOI 10.1523/JNEUROSCI.0236-05.2005
Komura Y, 2001, NATURE, V412, P546, DOI 10.1038/35087595
Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
Leader G, 2009, J AUTISM DEV DISORD, V39, P330, DOI 10.1007/s10803-008-0626-y
Liu Z, 2000, NAT NEUROSCI, V3, P1307
Lynn DA, 2009, DEV PSYCHOBIOL, V51, P513, DOI 10.1002/dev.20386
Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
Miller EK, 1996, J NEUROSCI, V16, P5154
Miller RR, 1985, CONTEXT LEARNING
Mooney DM, 2004, P NATL ACAD SCI USA, V101, P320, DOI 10.1073/pnas.0304445101
Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489
Mumby DG, 2002, LEARN MEMORY, V9, P49, DOI 10.1101/lm.41302
Mychasiuk R, 2012, DEV NEUROSCI-BASEL, V34, P268, DOI 10.1159/000341786
Naya Y, 2001, SCIENCE, V291, P661, DOI 10.1126/science.291.5504.661
Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
Paxinos G., 1991, ATLAS DEV RAT BRAIN
Posner M. I., 2008, TOPICS INTEGRATIVE N, P31, DOI 10.1017/CBO9780511541681.005
Raz A, 2006, NAT REV NEUROSCI, V7, P367, DOI 10.1038/nrn1903
Reed P, 2011, ASS LEARNING CONDITI
Roullet FI, 2013, NEUROTOXICOL TERATOL, V36, P47, DOI 10.1016/j.ntt.2013.01.004
Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
Spanswick SC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043698
Stamou M, 2013, NEUROTOXICOL TERATOL, V36, P3, DOI 10.1016/j.ntt.2012.12.001
VORHEES CV, 1987, TERATOLOGY, V35, P195, DOI 10.1002/tera.1420350205
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 54
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD MAY 30
PY 2014
VL 268
BP 212
EP 220
DI 10.1016/j.neuroscience.2014.02.049
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA AG6AX
UT WOS:000335501900019
PM 24631679
ER
PT J
AU Du, XN
An, Y
Yu, LF
Liu, RC
Qin, YR
Guo, XH
Sun, DK
Zhou, SZ
Wu, BL
Jiang, YH
Wang, Y
AF Du, Xiaonan
An, Yu
Yu, Lifei
Liu, Renchao
Qin, Yanrong
Guo, Xiaohong
Sun, Daokan
Zhou, Shuizhen
Wu, Bailin
Jiang, Yong-hui
Wang, Yi
TI A genomic copy number variant analysis implicates the MBD5 and HNRNPU
genes in Chinese children with infantile spasms and expands the clinical
spectrum of 2q23.1 deletion
SO BMC MEDICAL GENETICS
LA English
DT Article
DE Infantile spasms; Copy number variants; Array CGH; Autism spectrum
disorders; MBD5; HNRNPU
ID DE-NOVO MUTATIONS; EPILEPTIC ENCEPHALOPATHIES; INTELLECTUAL DISABILITY;
NEUREGULIN 3; MICRODELETION; RISK; SCHIZOPHRENIA; ABNORMALITIES;
DISORDERS; SEIZURES
AB Background: Infantile spasms (IS) is a specific type of epileptic encephalopathy associated with severe developmental disabilities. Genetic factors are strongly implicated in IS, however, the exact genetic defects remain unknown in the majority of cases. Rare mutations in a single gene or in copy number variants (CNVs) have been implicated in IS of children in Western countries. The objective of this study was to dissect the role of copy number variations in Chinese children with infantile spasms.
Methods: We used the Agilent Human Genome CGH microarray 180 K for genome-wide detection of CNVs. Real-time qPCR was used to validate the CNVs. We performed genomic and medical annotations for individual CNVs to determine the pathogenicity of CNVs related to IS.
Results: We report herein the first genome-wide CNV analysis in children with IS, detecting a total of 14 CNVs in a cohort of 47 Chinese children with IS. Four CNVs (4/47 = 8.5%) (1q21.1 gain; 1q44, 2q31.1, and 17p13 loss) are considered to be pathogenic. The CNV loss at 17p13.3 contains PAFAH1B1 (LIS1), a causative gene for lissencephaly. Although the CNVs at 1q21.1, 1q44, and 2q23.1 have been previously implicated in a wide spectrum of clinical features including autism spectrum disorders (ASD) and generalized seizure, our study is the first report identifying them in individuals with a primary diagnosis of IS. The CNV loss in the 1q44 region contains HNRNPU, a strong candidate gene recently suggested in IS by the whole exome sequencing of children with IS. The CNV loss at 2q23.1 includes MBD5, a methyl-DNA binding protein that is a causative gene of ASD and a candidate gene for epileptic encephalopathy. We also report a distinct clinical presentation of IS, microcephaly, intellectual disability, and absent hallux in a case with the 2q23.1 deletion.
Conclusion: Our findings strongly support the role of CNVs in infantile spasms and expand the clinical spectrum associate with 2q23.1 deletion. In particular, our study implicates the HNRNPU and MBD5 genes in Chinese children with IS. Our study also supports that the molecular mechanisms of infantile spasms appear conserved among different ethnic backgrounds.
C1 [Du, Xiaonan; Yu, Lifei; Guo, Xiaohong; Sun, Daokan; Zhou, Shuizhen; Wang, Yi] Fudan Univ, Childrens Hosp, Div Neurol, Shanghai 201102, Peoples R China.
[An, Yu; Liu, Renchao; Qin, Yanrong; Wu, Bailin] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China.
[An, Yu; Liu, Renchao; Qin, Yanrong; Wu, Bailin] Fudan Univ, MOE Key Lab Contemporary Anthropol, Shanghai 200032, Peoples R China.
[Wu, Bailin] Harvard Univ, Boston Childrens Hosp, Sch Med, Boston, MA USA.
[Jiang, Yong-hui] Duke Univ, Sch Med, Dept Pediat & Neurobiol, Div Med Genet, Durham, NC 27710 USA.
RP Jiang, YH (reprint author), Duke Univ, Sch Med, Dept Pediat & Neurobiol, Div Med Genet, 905 S LaSalle ST, Durham, NC 27710 USA.
EM yong-hui.jiang@duke.edu; yiwang@shmu.edu.cn
FU National Natural Science Foundation of China (NSCF) [81071116]; Shanghai
Committee of Science and Technology (STCSM) [12XD1401100]; 973 National
Basic Research Program of China [2010CB529601]; NIH [5R01MH098114-03]
FX We would like to thank all of families who participated in this project.
This study was supported by a grant from the National Natural Science
Foundation of China (NSCF, 81071116) and the Shanghai Committee of
Science and Technology (STCSM, 12XD1401100). YA is supported by the 973
National Basic Research Program of China (2010CB529601). YHJ is
supported by NIH 5R01MH098114-03.
CR Allen AS, 2013, NATURE, V501, P217, DOI 10.1038/nature12439
Amiet C, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-47
Basu S, 2003, MOL CELL, V11, P11, DOI 10.1016/S1097-2765(02)00776-1
Bird TD, 1993, GENEREVIEWS R
Bonnet C, 2013, EUR J HUM GENET, V21, P1457, DOI 10.1038/ejhg.2013.22
Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
Brunetti-Pierri N, 2011, EUR J HUM GENET, V19, P102, DOI 10.1038/ejhg.2010.142
Carvill GL, 2013, NAT GENET, V45, P825, DOI 10.1038/ng.2646
Dobyns WB, 1993, GENEREVIEWS R
Dolcetti A, 2013, GENET MED, V15, P282, DOI 10.1038/gim.2012.129
Du YR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047358
Epi K C, 2012, EPILEPSIA, V53, P1457
Faletra F, 2012, AM J MED GENET A, V158A, P461, DOI 10.1002/ajmg.a.34398
Fryns JP, 2002, HUM GENET, V111, P113
Guerrini R, 2001, AM J MED GENET, V106, P160, DOI 10.1002/ajmg.1569
Haldeman-Englert C, 1993, GENEREVIEWS R
Hatzimanolis A, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.33
Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
Hodge JC, 2014, MOL PSYCHIATR, V19, P368, DOI 10.1038/mp.2013.42
Kao WT, 2010, P NATL ACAD SCI USA, V107, P15619, DOI 10.1073/pnas.1005410107
Kato M, 2006, EPILEPSY RES, V70, pS87, DOI 10.1016/j.eplepsyres.2006.02.008
Lin CH, 2009, GENOMICS, V94, P241, DOI 10.1016/j.ygeno.2009.06.004
Liu PF, 2011, HUM MOL GENET, V20, P1975, DOI 10.1093/hmg/ddr078
Lou HY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027341
Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384
Mefford HC, 2010, GENOME MED, V2, DOI 10.1186/gm192
Mefford HC, 2011, ANN NEUROL, V70, P974, DOI 10.1002/ana.22645
Meier S, 2013, INT J NEUROPSYCHOPH, V16, P549, DOI 10.1017/S1461145712000697
Miltenberger-Miltenyi G, 2003, HUM MUTAT, V22, P107, DOI 10.1002/humu.10243
Paciorkowski AR, 2011, PEDIATR NEUROL, V45, P355, DOI 10.1016/j.pediatrneurol.2011.08.010
Paciorkowski AR, 2011, EUR J HUM GENET, V19, P1238, DOI 10.1038/ejhg.2011.121
Park H, 2010, NAT GENET, V42, P400, DOI 10.1038/ng.555
Pellock JM, 2010, EPILEPSIA, V51, P2175, DOI 10.1111/j.1528-1167.2010.02657.x
Polo SE, 2012, MOL CELL, V45, P505, DOI 10.1016/j.molcel.2011.12.035
Poot M, 2013, AM J MED GENET A, V161A, P910, DOI 10.1002/ajmg.a.35770
Saemundsen E, 2008, EPILEPSIA, V49, P1865, DOI 10.1111/j.1528-1167.2008.01688.x
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Shichiji M, 2013, AM J MED GENET A, V161A, P850, DOI 10.1002/ajmg.a.35768
Suls A, 2013, AM J HUM GENET, V93, P967, DOI 10.1016/j.ajhg.2013.09.017
Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011
Tang ChengCai, 2012, Journal of Resources and Ecology, V3, P8
Thierry G, 2012, AM J MED GENET A, V158A, P1633, DOI 10.1002/ajmg.a.35423
Tiwari VN, 2013, J CHILD NEUROL, V28, P1191, DOI 10.1177/0883073812453496
van Bon BWM, 2010, EUR J HUM GENET, V18, P163, DOI 10.1038/ejhg.2009.152
Verloes A, 2001, AM J MED GENET, V101, P209, DOI 10.1002/ajmg.1373
Yasui S, 2007, MOL CELL NEUROSCI, V35, P100, DOI 10.1016/j.mcn.2007.02.007
NR 47
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD MAY 29
PY 2014
VL 15
AR 62
DI 10.1186/1471-2350-15-62
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA AK2PY
UT WOS:000338262700001
PM 24885232
ER
PT J
AU Uutela, M
Lindholm, J
Rantamaki, T
Umemori, J
Hunter, K
Voikar, V
Castren, ML
AF Uutela, Marko
Lindholm, Jesse
Rantamaki, Tomi
Umemori, Juzoh
Hunter, Kerri
Voikar, Vootele
Castren, Maija L.
TI Distinctive behavioral and cellular responses to fluoxetine in the mouse
model for Fragile X syndrome
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Article
DE behavior; autism; BDNF; neurogenesis; TrkB receptors
ID AUTISTIC SPECTRUM DISORDERS; FMR1 KNOCKOUT MICE; NEUROTROPHIC FACTOR;
MENTAL-RETARDATION; MESSENGER-RNA; ANTIDEPRESSANT DRUGS; MUTANT MOUSE;
BRAIN; BDNF; CHILDREN
AB Fluoxetine is used as a therapeutic agent for autism spectrum disorder (ASD), including Fragile X syndrome (FXS). The treatment often associates with disruptive behaviors such as agitation and disinhibited behaviors in FXS. To identify mechanisms that increase the risk to poor treatment outcome, we investigated the behavioral and cellular effects of fluoxetine on adult Fmrl knockout (KO) mice, a mouse model for FXS. We found that fluoxetine reduced anxiety-like behavior of both wild-type and Fmrl KO mice seen as shortened latency to enter the center area in the open field test. In Fmrl KO mice, fluoxetine normalized locomotor hyperactivity but abnormally increased exploratory activity. Reduced brain-derived neurotrophic factor (BDNF) and increased TrkB receptor expression levels in the hippocampus of Fmrl KO mice associated with inappropriate coping responses under stressful condition and abolished antidepressant activity of fluoxetine. Fluoxetine response in the cell proliferation was also missing in the hippocampus of Fmrl KO mice when compared with wild-type controls. The postnatal mRNA expression of serotonin transporter (SERT) was reduced in the thalamic nuclei of Fmrl KO mice during the time of transient innervation of somatosensory neurons suggesting that developmental changes of SERT expression were involved in the differential cellular and behavioral responses to fluoxetine in wild-type and Fmrl mice. The results indicate that changes of BDNF/TrkB signaling contribute to differential behavioral responses to fluoxetine among individuals with ASD.
C1 [Uutela, Marko; Hunter, Kerri; Castren, Maija L.] Univ Helsinki, Inst Biomed Physiol, FIN-00014 Helsinki, Finland.
[Lindholm, Jesse; Rantamaki, Tomi; Umemori, Juzoh; Voikar, Vootele] Univ Helsinki, Ctr Neurosci, FIN-00014 Helsinki, Finland.
[Castren, Maija L.] Univ Helsinki Hosp, Hosp Children & Adolescents, Dept Child Neurol, Helsinki, Finland.
RP Castren, ML (reprint author), Univ Helsinki, Inst Biomed Physiol, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland.
EM maija.castren@helsinki.fi
FU Academy of Finland; Arvo and Lea Ylppo Foundation; Finnish Brain
Research Foundation
FX The authors thank Outi Nikki-hi for help in mouse genotyping and Dr.
Eero Castren for providing facilities for animal studies. Behavioral
studies were performed in MousQ Behavioral Unit that is supported by
Biocenter Finland, This study received financial support from the
Academy of Finland, Arvo and Lea Ylppo Foundation, and Finnish Brain
Research Foundation.
CR Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P116, DOI 10.1089/cap.2005.15.116
Banasr M, 2004, NEUROPSYCHOPHARMACOL, V29, P450, DOI 10.1038/sj.npp.1300320
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
Berton O, 2006, SCIENCE, V311, P864, DOI 10.1126/science.1120972
BROWN WT, 1986, AM J MED GENET, V23, P341, DOI 10.1002/ajmg.1320230126
Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148
Buchsbaum MS, 2001, INT J NEUROPSYCHOPH, V4, P119
Castren M, 2005, P NATL ACAD SCI USA, V102, P17834, DOI 10.1073/pnas.0508995102
Castren M, 2002, NEUROBIOL DIS, V11, P221, DOI 10.1006/nbdi.2002.0544
Castren ML, 2014, NEUROPHARMACOLOGY, V76, P729, DOI 10.1016/j.neuropharm.2013.05.018
Chen ZY, 2006, SCIENCE, V314, P140, DOI 10.1126/science.1129663
Connolly AM, 2006, BIOL PSYCHIAT, V59, P354, DOI 10.1016/j.biopsych.2005.07.004
BAKKER CE, 1994, CELL, V78, P23
Correia C. T., 2011, GENES BRAIN BEHAV, V9, P841, DOI [10.1111/j.1601-183X.2010.00627.x, DOI 10.1111/J.1601-183X.2010.00627.X]
Bernardet M, 2006, THESCIENTIFICWORLDJO, V6, P1164, DOI 10.1100/tsw.2006.220
Cryan JF, 2002, TRENDS PHARMACOL SCI, V23, P238, DOI 10.1016/S0165-6147(02)02017-5
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
DeLong GR, 2002, DEV MED CHILD NEUROL, V44, P652
DeLong GR, 1998, DEV MED CHILD NEUROL, V40, P551
Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Dolen G, 2009, J NEURODEV DISORD, V1, P133, DOI 10.1007/s11689-009-9015-x
Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
Garcia KLP, 2012, J NEUROPATH EXP NEUR, V71, P289, DOI 10.1097/NEN.0b013e31824b27e4
Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008
Hagerman R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-12
HAGERMAN RJ, 1994, DEV BRAIN DYSFUNCT, V7, P155
Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
Hernandez RN, 2009, AM J MED GENET A, V149A, P1125, DOI 10.1002/ajmg.a.32848
Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764
Hughes JR, 2009, EPILEPSY BEHAV, V16, P569, DOI 10.1016/j.yebeh.2009.09.023
Ibarguen-Vargas Y, 2009, BEHAV BRAIN RES, V202, P245, DOI 10.1016/j.bbr.2009.03.040
Iughetti L, 2011, NEUROPEPTIDES, V45, P205, DOI 10.1016/j.npep.2011.02.002
Karpova NN, 2009, EUR NEUROPSYCHOPHARM, V19, P97, DOI 10.1016/j.euroneuro.2008.09.002
Kernie SG, 2000, EMBO J, V19, P1290, DOI 10.1093/emboj/19.6.1290
Kim H, 2013, J NEUROSCI, V33, P15686, DOI 10.1523/JNEUROSCI.3246-12.2013
Kim HJ, 2013, BRAIN RES, V1490, P23, DOI 10.1016/j.brainres.2012.10.062
Kiryanova V, 2013, DEV NEUROSCI-BASEL, V35, P437, DOI 10.1159/000355709
Koponen E, 2005, CELL MOL NEUROBIOL, V25, P973, DOI 10.1007/s10571-005-8468-z
Lebrand C, 1996, NEURON, V17, P823, DOI 10.1016/S0896-6273(00)80215-9
Louhivuori V, 2011, NEUROBIOL DIS, V41, P469, DOI 10.1016/j.nbd.2010.10.018
Luo YP, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000898
Lyons WE, 1999, P NATL ACAD SCI USA, V96, P15239, DOI 10.1073/pnas.96.26.15239
MacQueen GM, 2001, BEHAV NEUROSCI, V115, P1145, DOI 10.1037//0735-7044.115.5.1145
Makkonen I., 2011, Journal of Pediatric Neurology, V9, P1
Maya-Vetencourt JF, 2008, SCIENCE, V320, P385, DOI 10.1126/science.1150516
Mineur YS, 2006, BEHAV BRAIN RES, V168, P172, DOI 10.1016/j.bbr.2005.11.004
Mineur YS, 2002, HIPPOCAMPUS, V12, P39, DOI 10.1002/hipo.10005
Miyazaki K, 2004, BRAIN DEV-JPN, V26, P292, DOI 10.1016/S0387-7604(03)00168-2
Monteggia LM, 2007, BIOL PSYCHIAT, V61, P187, DOI 10.1016/j.biopsych.2006.03.021
Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
NIBUYA M, 1995, J NEUROSCI, V15, P7539
Nielsen DM, 2002, BRAIN RES, V927, P8, DOI 10.1016/S0006-8993(01)03309-1
Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303
Peier AM, 2000, HUM MOL GENET, V9, P1145, DOI 10.1093/hmg/9.8.1145
Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058
PIVEN J, 1991, J AUTISM DEV DISORD, V21, P51, DOI 10.1007/BF02206997
PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
Rattiner LM, 2004, J NEUROSCI, V24, P4796, DOI 10.1523/JNEUROSCI.5654-03.2004
Rios M, 2001, MOL ENDOCRINOL, V15, P1748, DOI 10.1210/me.15.10.1748
Saarelainen T, 2003, J NEUROSCI, V23, P349
Sairanen M, 2005, J NEUROSCI, V25, P1089, DOI 10.1523/JNEUROSCI.3741-04.2005
Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.00123.x
Uutela M, 2012, GENES BRAIN BEHAV, V11, P513, DOI 10.1111/j.1601-183X.2012.00784.x
Van Dam D, 2000, BEHAV BRAIN RES, V117, P127, DOI 10.1016/S0166-4328(00)00296-5
Vitalis T, 2003, DEV NEUROSCI-BASEL, V25, P245, DOI 10.1159/000072272
Warner-Schmidt JL, 2006, HIPPOCAMPUS, V16, P239, DOI 10.1002/hipo.20156
Williams K, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004677.pub3
Wisden W., 1994, SITU HYBRIDIZATION P, P1
WONG DT, 1974, LIFE SCI, V15, P471, DOI 10.1016/0024-3205(74)90345-2
Wu XF, 2009, BIOL PSYCHIAT, V66, P5, DOI 10.1016/j.biopsych.2009.01.023
Xu ZH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048741
Zhao MG, 2005, J NEUROSCI, V25, P7385, DOI 10.1523/JNEUROSCI.1520-05.2005
NR 74
TC 4
Z9 4
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD MAY 28
PY 2014
VL 8
AR 150
DI 10.3389/fncel.2014.00150
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA AI1XR
UT WOS:000336649000002
PM 24904293
ER
PT J
AU Sylvester, J
Donnell, N
Gray, S
Higgins, K
Stalker, K
AF Sylvester, Janet
Donnell, Nigel
Gray, Shelley
Higgins, Kate
Stalker, Kirsten
TI A survey of disabled children and young people's views about their
quality of life
SO DISABILITY & SOCIETY
LA English
DT Article
DE children's views; disabled children and young people; survey; quality of
life; social relational understanding of disability
ID DISABILITY; CAREGIVERS; FAMILIES; AUTISM
AB This study aimed to explore disabled children and young people's perspectives about their quality of life, in terms of physical, mental and social well-being. Ninety-one disabled children, recruited through voluntary organisations in Scotland, completed KIDSCREEN-27, a validated measure of health-related quality of life for children. Findings were compared with those from a European study of predominantly non-disabled children. The children gave largely positive reports about school, family relationships and their physical health. However, one in three reported often feeling 'sad' and many were excluded from social activities with their peers. Expectations of achieving academic qualifications, and moving into further or higher education, were generally low. The children's perceived quality of life was lower than their European counterparts, less so in relation to school but particularly for friendships and peer support. The findings are discussed in the light of the social relational understanding of disability. Policy and practice implications are identified.
C1 [Sylvester, Janet; Donnell, Nigel] Scot Inform Ltd, Edinburgh, Midlothian, Scotland.
[Gray, Shelley] Hlth & Social Care Alliance, Glasgow, Lanark, Scotland.
[Higgins, Kate] Children 1st, Edinburgh, Midlothian, Scotland.
[Stalker, Kirsten] Univ Strathclyde, Glasgow Sch Social Work, Glasgow, Lanark, Scotland.
RP Stalker, K (reprint author), Univ Strathclyde, Glasgow Sch Social Work, Glasgow, Lanark, Scotland.
EM kirsten.stalker@strath.ac.uk
CR Abbott D, 2012, CHILD SOC, V26, P241, DOI 10.1111/j.1099-0860.2012.00437.x
Abbott D., 2010, BECOMING ADULT TRANS
Baldwin S., 1994, SOCIAL SUPPORT DISAB
Blackburn C. M., 2010, BMC PAEDIAT, V10
BYRNE EA, 1985, J CHILD PSYCHOL PSYC, V26, P847, DOI 10.1111/j.1469-7610.1985.tb00602.x
Cavet J., 1998, GROWING DISABILITY
Cole S., 2011, DISABLED CHILDREN YO
Colver A., 2009, LANCET, V30, P2171
Colville G., 2010, CRITICAL CARE, V14, P438
Connors C, 2007, DISABIL SOC, V22, P19, DOI 10.1080/09687590601056162
Emerson E, 2010, SOC INDIC RES SER, V41, P223, DOI 10.1007/978-90-481-9650-0_14
Emerson E, 2012, CHILD SOC, V26, P214, DOI 10.1111/j.1099-0860.2012.00434.x
Fallowfield L., 2007, WHAT IS QUALITY LIFE
Fauconnier J, 2009, BRIT MED J, V338, DOI 10.1136/bmj.b1458
Flynn M., 1992, THIS YEAR NEXT YEAR
Gray B., 2011, 1092011 SCOTT GOV RE, V109/2011
Heath J, 2011, PEDIATR NEPHROL, V26, P767, DOI 10.1007/s00467-011-1784-2
Jacobson L. F., 1968, SCIENTIFICAMERICAN, V218
James A., 1990, CONSTRUCTING RECONST
Kalyva E., 2010, PAEDIAT DIABETES, V12, P34
Karande S, 2009, J POSTGRAD MED, V55, P97, DOI 10.4103/0022-3859.52839
Kheir N, 2012, AUTISM, V16, P293, DOI 10.1177/1362361311433648
McConkey R., 2011, WORKING OUTSIDE BOX
Mencap, 2007, DONT STICK IT STOP I
Millar S., 2005, FE COMPLEX NEEDS VIE
Moscardini L., 2012, CRITICAL REV ANAL CU
Murray P., 2002, DISABLED TEENAGERS E
Newman G., 2009, WHAT MAKES GOOD LIFE
Oliver M., 1990, POLITICS DISABLEMENT
Priestley M, 2003, CHILD YOUTH SERV REV, V25, P863, DOI 10.1016/S0190-7409(03)00090-2
Ravens-Sieberer U, 2007, QUAL LIFE RES, V16, P1347, DOI 10.1007/s11136-007-9240-2
Ravens-Sieberer Ulrike, 2005, Expert Rev Pharmacoecon Outcomes Res, V5, P353, DOI 10.1586/14737167.5.3.353
Shu BC, 2009, AUTISM, V13, P81, DOI 10.1177/1362361307098517
The KIDSCREEN Group Europe, 2006, HANDBOOK
Thomas C., 2007, SOCIOLOGIES DISABILI
Thomas Carol, 1999, FEMALE FORMS EXPERIE
Thurston S., 2010, INT J PAEDIAT
Trust S. H. S., 2002, REAL CHOICES PARTICI
van Gameren-Oosterom HBM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021879
Watson N., 1999, LIFE DISABLED CHILD
WHO, 2009, PERC PHYS ACT CHILDR
Wickenden M., 2011, ESRC SEM SER RES LIV
Woolfson R.C., 2007, BRIT J SPECIAL ED, V34, P40, DOI 10.1111/j.1467-8578.2007.00452.x
World Health Organization Division of Mental Health and Prevention of Substance Abuse, 1997, WHOQOL MEAS QUAL LIF
Youthlink Scotland, 2009, BEING YOUNG SCOTL
NR 45
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0968-7599
EI 1360-0508
J9 DISABIL SOC
JI Disabil. Soc.
PD MAY 28
PY 2014
VL 29
IS 5
BP 763
EP 777
DI 10.1080/09687599.2013.848782
PG 15
WC Rehabilitation; Social Sciences, Interdisciplinary
SC Rehabilitation; Social Sciences - Other Topics
GA AH1MD
UT WOS:000335884000008
ER
PT J
AU Isomura, T
Ogawa, S
Yamada, S
Shibasaki, M
Masataka, N
AF Isomura, Tomoko
Ogawa, Shino
Yamada, Satoko
Shibasaki, Masahiro
Masataka, Nobuo
TI Preliminary evidence that different mechanisms underlie the anger
superiority effect in children with and without Autism Spectrum
Disorders
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE Autism Spectrum Disorders; anger superiority effect; children;
face-in-the-crowd effect; visual search; emotion; facial expressions;
attention
ID EMOTIONAL FACIAL EXPRESSIONS; VISUAL-SEARCH; CAPTURE ATTENTION; REAL
FACES; CROWD; THREAT; RESPONSES; STIMULI; PARTS
AB Previous studies have demonstrated that angry faces capture humans' attention more rapidly than emotionally positive faces. This phenomenon is referred to as the anger superiority effect (ASE). Despite atypical emotional processing, adults and children with Autism Spectrum Disorders (ASD) have been reported to show ASE as well as typically developed (TD) individuals. So far, however, few studies have clarified whether or not the mechanisms underlying ASE are the same for both TD and ASD individuals. Here, we tested how TD and ASD children process schematic emotional faces during detection by employing a recognition task in combination with a face-in-the-crowd task. Results of the face-in-the-crowd task revealed the prevalence of ASE both in TD and ASD children. However, the results of the recognition task revealed group differences: In TD children, detection of angry faces required more configural face processing and disrupted the processing of local features. In ASD children, on the other hand, it required more feature-based processing rather than configural processing. Despite the small sample sizes, these findings provide preliminary evidence that children with ASD, in contrast to TD children, show quick detection of angry faces by extracting local features in faces.
C1 [Isomura, Tomoko; Ogawa, Shino; Yamada, Satoko; Shibasaki, Masahiro; Masataka, Nobuo] Kyoto Univ, Primate Res Inst, Inuyama, Aichi 484, Japan.
RP Isomura, T (reprint author), Kyoto Univ, Primate Res Inst, 41-2 Kanrin, Inuyama, Aichi 484, Japan.
EM isomura.tomoko.35m@st.kyoto-u.ac.jp
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Ashwin C, 2006, BRAIN COGNITION, V61, P78, DOI 10.1016/j.bandc.2005.12.008
Beall PM, 2008, J EXP CHILD PSYCHOL, V101, P206, DOI 10.1016/j.jecp.2008.04.004
Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
DUNCAN J, 1989, PSYCHOL REV, V96, P433, DOI 10.1037//0033-295X.96.3.433
Eastwood JD, 2001, PERCEPT PSYCHOPHYS, V63, P1004, DOI 10.3758/BF03194519
Eastwood JD, 2008, VIS COGN, V16, P248, DOI 10.1080/13506280701434383
Eastwood JD, 2003, PERCEPT PSYCHOPHYS, V65, P352, DOI 10.3758/BF03194566
Fox E, 2000, COGNITION EMOTION, V14, P61
HANSEN CH, 1988, J PERS SOC PSYCHOL, V54, P917, DOI 10.1037/0022-3514.54.6.917
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Horstmann G, 2006, EMOTION, V6, P193, DOI 10.1037/1528-3542.6.2.193
Horstmann G, 2007, VIS COGN, V15, P799, DOI 10.1080/13506280600892798
Horstmann G, 2009, COGNITION EMOTION, V23, P355, DOI 10.1080/02699930801976523
Krysko KM, 2009, BRAIN COGNITION, V69, P472, DOI 10.1016/j.bandc.2008.10.002
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
Ohman A, 2001, J PERS SOC PSYCHOL, V80, P381, DOI 10.1037//0022-3514.80.3.381
OHMAN A, 1993, J ABNORM PSYCHOL, V102, P121
Pinkham AE, 2010, EMOTION, V10, P141, DOI 10.1037/a0017387
Rosset D, 2011, RES AUTISM SPECT DIS, V5, P949, DOI 10.1016/j.rasd.2010.11.005
Rozga A, 2013, DEVELOPMENTAL SCI, V16, P499, DOI 10.1111/desc.12062
Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P187, DOI 10.1007/s10803-006-0151-9
TANAKA JW, 1993, Q J EXP PSYCHOL-A, V46, P225
TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
Tipples J, 2002, Q J EXP PSYCHOL-A, V55, P1007, DOI 10.1080/02724980143000659
Tran US, 2013, J RES PERS, V47, P390, DOI 10.1016/j.jrp.2013.03.007
Vuilleumier P, 2001, NEUROLOGY, V56, P153
Wagner JB, 2013, J AUTISM DEV DISORD, V43, P188, DOI 10.1007/s10803-012-1565-1
Wakabayashi A, 2006, J AUTISM DEV DISORD, V36, P263, DOI 10.1007/s10803-005-0061-2
Weymar M, 2011, NEUROIMAGE, V58, P946, DOI 10.1016/j.neuroimage.2011.06.061
Wilford MM, 2010, PSYCHOL SCI, V21, P1611, DOI 10.1177/0956797610385952
YIN RK, 1969, J EXP PSYCHOL, V81, P141, DOI 10.1037/h0027474
NR 33
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 27
PY 2014
VL 5
AR 461
DI 10.3389/fpsyg.2014.00461
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA AI6JR
UT WOS:000336980400001
PM 24904477
ER
PT J
AU Tenenbaum, EJ
Amso, D
Abar, B
Sheinkopf, SJ
AF Tenenbaum, Elena J.
Amso, Dima
Abar, Beau
Sheinkopf, Stephen J.
TI Attention and word learning in autistic, language delayed, and typically
developing children
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE autism spectrum disorders; eye tracking; word learning; attention to
faces; language development
ID DIAGNOSTIC OBSERVATION SCHEDULE; JOINT ATTENTION; SPECTRUM DISORDERS;
MUTUAL EXCLUSIVITY; VOCABULARY GROWTH; YOUNG-CHILDREN; GAZE BEHAVIOR;
SOCIAL SCENES; 2ND YEAR; INFANTS
AB Previous work has demonstrated that patterns of social attention hold predictive value for language development in typically developing infants. The goal of this research was to explore how patterns of attention in autistic, language delayed, and typically developing children relate to early word learning and language abilities. We tracked patterns of eye movements to faces and objects while children watched videos of a woman teaching them a series of new words. Subsequent test trials measured participants' recognition of these novel word-object pairings. Results indicated that greater attention to the speaker's mouth was related to higher scores on standardized measures of language development for autistic and typically developing children (but not for language delayed children). This effect was mediated by age for typically developing, but not autistic children. When effects of age were controlled for, attention to the mouth among language delayed participants was negatively correlated with standardized measures of language learning. Attention to the speaker's mouth and eyes while she was teaching the new words was also predictive of faster recognition of those words among autistic children. These results suggest that language delays among children with autism may be driven in part by aberrant social attention, and that the mechanisms underlying these delays may differ from those in language delayed participants without autism.
C1 [Tenenbaum, Elena J.; Sheinkopf, Stephen J.] Brown Univ, Women & Infants Hosp, Brown Ctr Study Children Risk, Providence, RI 02905 USA.
[Amso, Dima] Brown Univ, Dept Cognit Linguist & Psychol Sci, Providence, RI 02905 USA.
[Abar, Beau] Univ Rochester, Med Ctr, Sch Med & Dent, Rochester, NY 14642 USA.
[Sheinkopf, Stephen J.] Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
RP Tenenbaum, EJ (reprint author), Brown Univ, Women & Infants Hosp, Brown Ctr Study Children Risk, 101 Dudley St, Providence, RI 02905 USA.
EM etenenbaum@wihri.org
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
BALDWIN DA, 1991, CHILD DEV, V62, P875, DOI 10.2307/1131140
BARONCOHEN S, 1994, CAH PSYCHOL COGN, V13, P513
Bayley N., 2005, BAYLEY SCALES INFANT, Vthird
Bono MA, 2004, J AUTISM DEV DISORD, V34, P495, DOI 10.1007/s10803-004-2545-x
Brooks R, 2008, J CHILD LANG, V35, P207, DOI 10.1017/S030500090700829X
Brooks R, 2005, DEVELOPMENTAL SCI, V8, P535, DOI 10.1111/j.1467-7687.2005.00445.x
Bruinsma Y, 2004, MENT RETARD DEV D R, V10, P169, DOI 10.1002/mrdd.20036
Carpenter M, 1998, Monogr Soc Res Child Dev, V63, pi, DOI 10.2307/1166214
Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
Chawarska K, 2013, BIOL PSYCHIAT, V74, P195, DOI 10.1016/j.biopsych.2012.11.022
Chawarska K, 2012, J CHILD PSYCHOL PSYC, V53, P903, DOI 10.1111/j.1469-7610.2012.02538.x
Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
de Marchena A, 2011, COGNITION, V119, P96, DOI 10.1016/j.cognition.2010.12.011
Fenson L, 2007, MACARTHUR BATES COMM
Fernald A, 2008, DEVELOPMENTAL PSYCHOLINGUISTICS: ON-LINE METHODS IN CHILDREN'S LANGUAGE PROCESSING, P97
Fernald A, 1998, PSYCHOL SCI, V9, P228, DOI 10.1111/1467-9280.00044
Fernald A, 2006, DEV PSYCHOL, V42, P98, DOI 10.1037/0012-1649.42.1.98
Frank M. C., 2011, IEEE MTT S INT MICR, P1, DOI 10.1111/j.1532-7078.2011.00086.x
Gliga T, 2012, CHILD DEV, V83, P926, DOI 10.1111/j.1467-8624.2012.01750.x
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Leekam SR, 1998, J CHILD PSYCHOL PSYC, V39, P951, DOI 10.1017/S0021963098003035
Lenth R. V., 2006, JAVA APPLETS POWER S
Lewkowicz DJ, 2012, P NATL ACAD SCI USA, V109, P1431, DOI 10.1073/pnas.1114783109
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Marchman VA, 2008, DEVELOPMENTAL SCI, V11, pF9, DOI 10.1111/j.1467-7687.2008.00671.x
MARKMAN EM, 1988, COGNITIVE PSYCHOL, V20, P121, DOI 10.1016/0010-0285(88)90017-5
Medina TN, 2011, P NATL ACAD SCI USA, V108, P9014, DOI 10.1073/pnas.1105040108
Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4
Merriman W E, 1989, Monogr Soc Res Child Dev, V54, P1
Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y
Morales M, 2000, J APPL DEV PSYCHOL, V21, P283, DOI 10.1016/S0193-3973(99)00040-4
Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
Mundy P, 2001, INT REV RES MENT RET, V23, P139
MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
Nakano T, 2010, P ROY SOC B-BIOL SCI, V277, P2935, DOI 10.1098/rspb.2010.0587
Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
Oakes LM, 2012, INFANCY, V17, P1, DOI 10.1111/j.1532-7078.2011.00101.x
Parish-Morris J, 2007, CHILD DEV, V78, P1265, DOI 10.1111/j.1467-8624.2007.01065.x
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Rutter M., 2003, SCQ SOCIAL COMMUNICA
Senju A, 2008, CURR BIOL, V18, P668, DOI 10.1016/j.cub.2008.03.059
Shic F, 2011, BRAIN RES, V1380, P246, DOI 10.1016/j.brainres.2010.11.074
Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x
Smith K, 2011, COGNITIVE SCI, V35, P480, DOI 10.1111/j.1551-6709.2010.01158.x
Smith L, 2008, COGNITION, V106, P1558, DOI 10.1016/j.cognition.2007.06.010
Smith L. B., 2000, LEARNING LEARN WORDS
Tager-Flusberg H, 2006, CLIN NEUROSCI RES, V6, P219, DOI 10.1016/j.cnr.2006.06.007
Trueswell JC, 2013, COGNITIVE PSYCHOL, V66, P126, DOI 10.1016/j.cogpsych.2012.10.001
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
Wetherby AM, 2002, J SPEECH LANG HEAR R, V45, P1202, DOI 10.1044/1092-4388(2002/097)
Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 58
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 26
PY 2014
VL 5
AR 490
DI 10.3389/fpsyg.2014.00490
PG 9
WC Psychology, Multidisciplinary
SC Psychology
GA AI5UN
UT WOS:000336934800001
PM 24904503
ER
PT J
AU Silva, IMW
Rosenfeld, J
Antoniuk, SA
Raskin, S
Sotomaior, VS
AF Silva, Isabela M. W.
Rosenfeld, Jill
Antoniuk, Sergio A.
Raskin, Salmo
Sotomaior, Vanessa S.
TI A 1.5 Mb terminal deletion of 12p associated with autism spectrum
disorder
SO GENE
LA English
DT Article
DE Autism spectrum disorder; 12p13.33 microdeletion; Array comparative
genomic hybridization; ERC1; Neurodevelopmental delay
ID SUBTELOMERIC DELETION; MICRODELETION; RELEASE; ELKS
AB We report a patient with a terminal 12p deletion associated with autism spectrum disorder (ASD). This 12p13.33 deletion is 1.5 Mb in size and encompasses 13 genes (B4GALNT3, CCDC77, ERC1, FBXL14, IQSEC3, KDM5A, LINC00942, L00574538, NINJ2, RAD52, SLC6Al2, SLC6A13 and WNK1). All previous cases reported with partial monosomy of 12p13.33 are associated with neurodevelopmental delay, and we suggest that ERC1, which encodes a regulator of neurotransmitter release, is the best gene candidate contributing to this phenotype as well as to the ASD of our patient. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Silva, Isabela M. W.] Pontificia Univ Catolica Parana, Sch Hlth & Biosci, Grp Adv Mol Invest NIMA, BR-11558021 Curitiba, Parana, Brazil.
[Rosenfeld, Jill] PerkinElmer Inc, Signature Genom, Spokane, WA USA.
[Antoniuk, Sergio A.] Univ Fed Parana, Dept Pediat, BR-80060000 Curitiba, Parana, Brazil.
[Raskin, Salmo] GENETIKA Ctr Aconselhamento & Lab Genet, Curitiba, Parana, Brazil.
[Raskin, Salmo; Sotomaior, Vanessa S.] Pontificia Univ Catolica Parana, Sch Med, Grad Program Hlth Sci, Grp Adv Mol Invest NIMA, BR-11558021 Curitiba, Parana, Brazil.
RP Sotomaior, VS (reprint author), Pontificia Univ Catolica Parana, Escola Med, Programs Posgrad Ciencias Saude, Rua Imaculada Conceicao 1155, BR-11558021 Curitiba, Parana, Brazil.
EM vanessa.sotomaior@pucpr.br
CR Abdelmoity AT, 2011, EUR J MED GENET, V54, P198, DOI 10.1016/j.ejmg.2010.11.010
[Anonymous], DIAGN STAT MAN MENT
Baker E, 2002, CLIN GENET, V61, P198, DOI 10.1034/j.1399-0004.2002.610305.x
Ballif BC, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-8
Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
Duker AL, 2010, EUR J HUM GENET, V18, P1196, DOI 10.1038/ejhg.2010.102
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
MacDonald AH, 2010, AM J MED GENET A, V152A, P1561, DOI 10.1002/ajmg.a.33401
Nakata T, 2002, GENE CHROMOSOME CANC, V35, P30, DOI 10.1002/gcc.10095
Nomura H, 2009, CELL IMMUNOL, V258, P204, DOI 10.1016/j.cellimm.2009.05.005
Rooryck C, 2009, EUR J MED GENET, V52, P446, DOI 10.1016/j.ejmg.2009.08.005
Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shaikh TH, 2009, GENOME RES, V19, P1682, DOI 10.1101/gr.083501.108
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Swanwick C.C., 2011, AUTISM SPECTRUM DISO
Takao-Rikitsu E, 2004, J CELL BIOL, V164, P301, DOI 10.1083/jcb.200307101
Thevenon J., 2012, EUR J HUM GENET, V21, P82
Traylor RN, 2009, MOL CYTOGENET, V2, DOI 10.1186/1755-8166-2-17
Veenstra-VanderWeele J, 2004, MOL PSYCHIATR, V9, P819, DOI 10.1038/sj.mp.4001505
NR 20
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD MAY 25
PY 2014
VL 542
IS 1
BP 83
EP 86
DI 10.1016/j.gene.2014.02.058
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA AG3CR
UT WOS:000335293900012
PM 24613754
ER
PT J
AU Eldridge, J
Lane, AE
Belkin, M
Dennis, S
AF Eldridge, Justin
Lane, Alison E.
Belkin, Mikhail
Dennis, Simon
TI Robust features for the automatic identification of autism spectrum
disorder in children
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Event-related potential; EEG; Classification
ID DIAGNOSTIC OBSERVATION SCHEDULE; RATING-SCALE; BLINK RATE; COHERENCE;
VALIDITY; CONNECTIVITY; POTENTIALS; ARTIFACTS; BEHAVIOR; SUBTYPES
AB Background: It is commonly reported that children with autism spectrum disorder (ASD) exhibit hyper-reactivity or hypo-reactivity to sensory stimuli. Electroencephalography (EEG) is commonly used to study neural sensory reactivity, suggesting that statistical analysis of EEG recordings is a potential means of automatic classification of the disorder. EEG recordings taken from children, however, are frequently contaminated with large amounts of noise, making analysis difficult. In this paper, we present a method for the automatic extraction of noise-robust EEG features, which serve to quantify neural sensory reactivity. We show the efficacy of a system for the classification of ASD using these features.
Methods: An oddball paradigm was used to elicit event-related potentials from a group of 19 ASD children and 30 typically developing children. EEG recordings were taken and robust features were extracted. A support vector machine, logistic regression, and a naive Bayes classifier were used to classify the children as having ASD or being typically developing.
Results: A classification accuracy of 79% was achieved, making our method competitive with other automatic diagnosis methods based on EEG. Additionally, we found that classification performance is reduced if eye blink artifacts are removed during preprocessing.
Conclusions: This study shows that robust EEG features that quantify neural sensory reactivity are useful for the classification of ASD. We showed that noise-robust features are crucial for our analysis, and observe that traditional preprocessing methods may lead to poor classification performance in the face of a large amount of noise. Further exploration of alternative preprocessing methods is warranted.
C1 [Eldridge, Justin; Belkin, Mikhail] Ohio State Univ, Dept Comp Sci & Engn, Columbus, OH 43210 USA.
[Lane, Alison E.] Univ Newcastle, Sch Hlth Sci, Callaghan, NSW 2308, Australia.
[Dennis, Simon] Univ Newcastle, Sch Psychol, Callaghan, NSW 2308, Australia.
RP Eldridge, J (reprint author), Ohio State Univ, Dept Comp Sci & Engn, 395 Dreese Labs,2015 Neil Ave, Columbus, OH 43210 USA.
EM eldridge@cse.ohio-state.edu
FU Ohio State University Center for Clinical and Translational Science
[UL1RR025755]; National Center for Research Resources; National Center
for Advancing Translational Sciences [8KL2TR000112-05, 8UL1TR000090-05,
8TL1TR000091-05]; Center for Cognitive Science at the Ohio State
University
FX We would like to thank Karen Harpster and Brittany Hand. This project
was partially supported by grants to AEL from the Ohio State University
Center for Clinical and Translational Science (Award Number UL1RR025755)
and from the National Center for Research Resources and the National
Center for Advancing Translational Sciences (8KL2TR000112-05,
8UL1TR000090-05, and 8TL1TR000091-05). The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the National Institutes of Health. JE's work was
partially funded by a fellowship from the Center for Cognitive Science
at the Ohio State University.
CR Anderson KA, 2013, AUTISM
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Ben-Sasson A, 2009, J ABNORM CHILD PSYCH, V37, P705, DOI 10.1007/s10802-008-9295-8
Bosl W, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-18
Caplan R, 1996, BIOL PSYCHIAT, V39, P1032, DOI 10.1016/0006-3223(95)00315-0
Center for Disease Control and Prevention, 2008, SURVEILL SUMM, V61, P1
Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
Cruz AAV, 2011, OCUL SURF, V9, P29
Duffy FH, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-64
EAVES RC, 1993, J ABNORM CHILD PSYCH, V21, P481, DOI 10.1007/BF00916315
GARFIN DG, 1988, J AUTISM DEV DISORD, V18, P367, DOI 10.1007/BF02212193
GOLDBERG TE, 1987, J AM ACAD CHILD PSY, V26, P336, DOI 10.1097/00004583-198705000-00009
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Hand DJ, 2006, STAT SCI, V21, P1, DOI 10.1214/088342306000000060
Handy T. C, 2005, EVENT RELATED POTENT
Isler JR, 2010, CLIN NEUROPHYSIOL, V121, P2035, DOI 10.1016/j.clinph.2010.05.004
Jeste SS, 2009, J AUTISM DEV DISORD, V39, P495, DOI 10.1007/s10803-008-0652-9
Jung TP, 2000, PSYCHOPHYSIOLOGY, V37, P163, DOI 10.1017/S0048577200980259
Junghofer M, 2000, PSYCHOPHYSIOLOGY, V37, P523, DOI 10.1017/S0048577200980624
Klintwall L, 2011, RES DEV DISABIL, V32, P795, DOI 10.1016/j.ridd.2010.10.021
Lane A, 2014, AUTISM RES
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luck S. J., 2005, INTRO EVENT RELATED
Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
Pedregosa F, 2011, J MACH LEARN RES, V12, P2825
Schopler E, 2010, CHILDHOOD AUSTIM RAT
Schopler E, 1988, CHILD AUSTIM RATING
Theodoridis S, 2009, PATTERN RECOGNITION, 4RTH EDITION, P1
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
NR 32
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD MAY 23
PY 2014
VL 6
AR 12
DI 10.1186/1866-1955-6-12
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AK5MJ
UT WOS:000338468500001
PM 24936212
ER
PT J
AU Chong, WWS
Lo, IFM
Lam, STS
Wang, CC
Luk, HM
Leung, TY
Choy, KW
AF Chong, Wilson Wai Sing
Lo, Ivan Fai Man
Lam, Stephen Tak Sum
Wang, Chi Chiu
Luk, Ho Ming
Leung, Tak Yeung
Choy, Kwong Wai
TI Performance of chromosomal microarray for patients with intellectual
disabilities/developmental delay, autism, and multiple congenital
anomalies in a Chinese cohort
SO MOLECULAR CYTOGENETICS
LA English
DT Article
DE Chromosomal microarray; Array CGH; Developmental delay; Intellectual
disabilities; Multiple congenital anomalies
ID COMPARATIVE GENOMIC HYBRIDIZATION; COPY-NUMBER VARIANTS;
MENTAL-RETARDATION; DEVELOPMENTAL DELAY; ARRAY-CGH; SUBTELOMERIC
REGIONS; DYSMORPHIC FEATURES; AMERICAN-COLLEGE; DISABILITY; DISORDERS
AB Background: Chromosomal microarray (CMA) is currently the first-tier genetic test for patients with idiopathic neuropsychiatric diseases in many countries. Its improved diagnostic yield over karyotyping and other molecular testing facilitates the identification of the underlying causes of neuropsychiatric diseases. In this study, we applied oligonucleotide array comparative genomic hybridization as the molecular genetic test in a Chinese cohort of children with DD/ID, autism or MCA.
Results: CMA identified 7 clinically significant microduplications and 17 microdeletions in 19.0% (20/105) patients, with size of aberrant regions ranging from 11 kb to 10.7 Mb. Fourteen of the pathogenic copy number variant (CNV) detected corresponded to well known microdeletion or microduplication syndromes. Four overlapped with critical regions of recently identified genomic syndromes. We also identified a rare de novo 2.3 Mb deletion at 8p21.3-21.2 as a pathogenic submicroscopic CNV. We also identified two novel CNVs, one at Xq28 and the other at 12q21.31-q21.33, in two patients (1.9%) with unclear clinical significance. Overall, the detection rate of CMA is comparable to figures previously reported for accurately detect submicroscopic chromosomal imbalances and pathogenic CNVs except mosaicism, balanced translocation and inversion.
Conclusions: This study provided further evidence of an increased diagnostic yield of CMA and supported its use as a first line diagnostic tool for Chinese individuals with DD/ID, ASD, and MCA.
C1 [Chong, Wilson Wai Sing; Wang, Chi Chiu; Leung, Tak Yeung; Choy, Kwong Wai] Chinese Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Hong Kong, Peoples R China.
[Chong, Wilson Wai Sing; Wang, Chi Chiu; Leung, Tak Yeung; Choy, Kwong Wai] Prince Wales Hosp, Prenatal Genet Diag Lab, Shatin, Hong Kong, Peoples R China.
[Lo, Ivan Fai Man; Lam, Stephen Tak Sum; Luk, Ho Ming] Dept Hlth, Clin Genet Serv, Hong Kong, Hong Kong, Peoples R China.
[Choy, Kwong Wai] Chinese Univ Hong Kong, CUHK Shenzhen Res Inst, Shenzhen, Peoples R China.
[Choy, Kwong Wai] Chinese Univ Hong Kong, Sch Biomed Sci, Joint Ctr Utrecht Univ Genet Core, Hong Kong, Hong Kong, Peoples R China.
RP Choy, KW (reprint author), Chinese Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Hong Kong, Peoples R China.
EM richardchoy@cuhk.edu.hk
FU Health and Health Services Research Fund [08090401]; National Basic
Research Program of China [81370715]
FX This work was supported by Health and Health Services Research Fund
(08090401) and the National Basic Research Program of China (81370715).
CR Bartnik M, 2012, AM J MED GENET B, V159B, P760, DOI 10.1002/ajmg.b.32081
Bi W, 2012, GENET MED, V15, P450
Bruno DL, 2009, J MED GENET, V46, P123, DOI 10.1136/jmg.2008.062604
Callier P, 2013, CLIN GENET, V84, P507, DOI 10.1111/cge.12094
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Cuturilo G, 2011, EUR J PEDIATR, V170, P1465, DOI 10.1007/s00431-011-1533-3
Friedman JM, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-526
Friedman JM, 2006, AM J HUM GENET, V79, P500, DOI 10.1086/507471
Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
Hayashi S, 2008, AM J MED GENET A, V146A, P2905, DOI 10.1002/ajmg.a.32519
Hayashi S, 2011, J HUM GENET, V56, P110, DOI 10.1038/jhg.2010.129
Hochstenbach R, 2009, EUR J MED GENET, V52, P161, DOI 10.1016/j.ejmg.2009.03.015
Iourov IY, 2012, MOL CYTOGENET, V5, DOI 10.1186/1755-8166-5-46
Kearney HM, 2011, GENET MED, V13, P676, DOI 10.1097/GIM.0b013e31822272ac
Kearney HM, 2011, GENET MED, V13, P680, DOI 10.1097/GIM.0b013e3182217a3a
Lee C, 2007, NAT GENET, V39, pS48, DOI 10.1038/ng2092
Leung TY, 2011, ULTRASOUND OBST GYN, V38, P314, DOI 10.1002/uog.8988
Lu XY, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000327
Lu XY, 2008, PEDIATRICS, V122, P1310, DOI 10.1542/peds.2008-0297
McMullan DJ, 2009, HUM MUTAT, V30, P1082, DOI 10.1002/humu.21015
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Rauch A, 2006, AM J MED GENET A, V140A, P2063, DOI 10.1002/ajmg.a.31416
Reddy S, 2009, EUR J MED GENET, V52, P443, DOI 10.1016/j.ejmg.2009.09.003
Riggs ER, 2012, CLIN GENET, V81, P403, DOI 10.1111/j.1399-0004.2011.01818.x
Rodriguez-Revenga L, 2013, GENE, V521, P82, DOI 10.1016/j.gene.2013.02.043
Sanna-Cherchi S, 2012, AM J HUM GENET, V91, P987, DOI 10.1016/j.ajhg.2012.10.007
Shao L, 2008, AM J MED GENET A, V146A, P2242, DOI 10.1002/ajmg.a.32399
Siggberg L, 2010, AM J MED GENET A, V152A, P1398, DOI 10.1002/ajmg.a.33402
Syrmou A, 2013, PEDIATR RES, V73, P772, DOI 10.1038/pr.2013.41
Thienpont B, 2010, J MED GENET, V47, P155, DOI 10.1136/jmg.2009.070573
Toruner GA, 2007, AM J MED GENET A, V143A, P824, DOI 10.1002/ajmg.a.31656
Tsai ACH, 2011, EUR J HUM GENET, V19, P43, DOI 10.1038/ejhg.2010.121
Valetto A, 2012, EUR J MED GENET, V55, P362, DOI 10.1016/j.ejmg.2012.03.011
van Bon BWM, 2011, EUR J HUM GENET, V19, P400, DOI 10.1038/ejhg.2010.211
Vorstman JAS, 2011, MOL PSYCHIATR, V16, P442, DOI 10.1038/mp.2010.26
Wei Y, 2013, J GENET GENOMICS, V40, P1, DOI 10.1016/j.jgg.2012.12.004
Wincent J, 2011, CLIN GENET, V79, P147, DOI 10.1111/j.1399-0004.2010.01442.x
Wisniowiecka-Kowalnik B, 2012, EUR J HUM GENET, V21, P620
Youngs EL, 2012, CLIN DYSMORPHOL, V21, P93
NR 40
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8166
J9 MOL CYTOGENET
JI Mol. Cytogenet.
PD MAY 23
PY 2014
VL 7
AR 34
DI 10.1186/1755-8166-7-34
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AJ3DZ
UT WOS:000337547200001
PM 24926319
ER
PT J
AU Steinhorst, A
Funke, J
AF Steinhorst, Alina
Funke, Joachim
TI Mirror neuron activity is no proof for action understanding
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE mirror neuron activity; action understanding; action recognition;
function of the mirror neuron system; goal coding
ID PREMOTOR CORTEX; AUTISM; RECOGNITION; IMPAIRMENT; IMITATION; ENCODE;
SYSTEM; FMRI
C1 [Steinhorst, Alina; Funke, Joachim] Heidelberg Univ, Dept Psychol, Heidelberg, Germany.
RP Funke, J (reprint author), Heidelberg Univ, Dept Psychol, Heidelberg, Germany.
EM joachim.funke@psychologie.uni-heidelberg.de
RI Funke, Joachim/B-7773-2008
OI Funke, Joachim/0000-0001-9129-2659
CR BLOCK NJ, 1972, PHILOS REV, V81, P159, DOI 10.2307/2183991
Borg E, 2007, J CONSCIOUSNESS STUD, V14, P5
Buccino G, 2004, J COGNITIVE NEUROSCI, V16, P114, DOI 10.1162/089892904322755601
Caggiano V, 2009, SCIENCE, V324, P403, DOI 10.1126/science.1166818
Caggiano V, 2012, P NATL ACAD SCI USA, V109, P11848, DOI 10.1073/pnas.1205553109
Calvo-Merino B, 2005, CEREB CORTEX, V15, P1243, DOI 10.1093/cercor/bhi007
Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
Csibra G, 1993, SENSORIMOTOR FDN HIG, P435, DOI [10.1093/acprof:oso/9780199231447.003.0020, DOI 10.1093/ACPR0F:0S0/9780199231447.003.0020]
Dilthey W, 1961, GESAMMELTE SCHRIFTEN
Ferrari PF, 2005, J COGNITIVE NEUROSCI, V17, P212, DOI 10.1162/0898929053124910
Frith U, 2012, Q J EXP PSYCHOL, V65, P2073, DOI 10.1080/17470218.2012.697178
Gadamer H.-G., 1990, HERMENEUTIK WAHRHEIT
Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
Hickok G, 2009, J COGNITIVE NEUROSCI, V21, P1229, DOI 10.1162/jocn.2009.21189
Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
Jacob P, 2008, MIND LANG, V23, P190, DOI 10.1111/j.1468-0017.2007.00337.x
Jacob P, 2005, TRENDS COGN SCI, V9, P21, DOI 10.1016/j.tics.2004.11.003
Kohler E, 2002, SCIENCE, V297, P846, DOI 10.1126/science.1070311
PLACE UT, 1956, BRIT J PSYCHOL, V47, P44
Popper KR, 1966, LOGIK FORSCHUNG
Putnam H., 1967, ART MIND RELIG, P37
Rizzolatti G., 2008, EMPATHIE SPIEGELNEUR
Rizzolatti G, 1996, COGNITIVE BRAIN RES, V3, P131, DOI 10.1016/0926-6410(95)00038-0
Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
Rizzolatti G, 2001, NAT REV NEUROSCI, V2, P661, DOI 10.1038/35090060
SMART JJC, 1959, PHILOS REV, V68, P141, DOI 10.2307/2182164
Southgate Victoria, 2009, P331, DOI 10.1007/978-1-59745-479-7_15
Umilta MA, 2001, NEURON, V31, P155, DOI 10.1016/S0896-6273(01)00337-3
Umilta MA, 2008, P NATL ACAD SCI USA, V105, P2209, DOI 10.1073/pnas.0705985105
Wood JN, 2007, BIOLOGY LETT, V3, P360, DOI 10.1098/rsbl.2007.0107
NR 30
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD MAY 22
PY 2014
VL 8
AR 333
DI 10.3389/fnhum.2014.00333
PG 4
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AL9XQ
UT WOS:000339497300001
PM 24904373
ER
PT J
AU Halliday, DWR
MacDonald, SWS
Sherf, SK
Tanaka, JW
AF Halliday, Drew W. R.
MacDonald, Stuart W. S.
Sherf, Suzanne K.
Tanaka, James W.
TI A Reciprocal Model of Face Recognition and Autistic Traits: Evidence
from an Individual Differences Perspective
SO PLOS ONE
LA English
DT Article
ID SPECTRUM QUOTIENT AQ; DEVELOPMENTAL PROSOPAGNOSIA; OBJECT RECOGNITION;
SEX-DIFFERENCES; SKILLS BATTERY; DISORDER; CHILDREN; POPULATION;
PERCEPTION; REGRESSION
AB Although not a core symptom of the disorder, individuals with autism often exhibit selective impairments in their face processing abilities. Importantly, the reciprocal connection between autistic traits and face perception has rarely been examined within the typically developing population. In this study, university participants from the social sciences, physical sciences, and humanities completed a battery of measures that assessed face, object and emotion recognition abilities, general perceptual-cognitive style, and sub-clinical autistic traits (the Autism Quotient (AQ)). We employed separate hierarchical multiple regression analyses to evaluate which factors could predict face recognition scores and AQ scores. Gender, object recognition performance, and AQ scores predicted face recognition behaviour. Specifically, males, individuals with more autistic traits, and those with lower object recognition scores performed more poorly on the face recognition test. Conversely, university major, gender and face recognition performance reliably predicted AQ scores. Science majors, males, and individuals with poor face recognition skills showed more autistic-like traits. These results suggest that the broader autism phenotype is associated with lower face recognition abilities, even among typically developing individuals.
C1 [Halliday, Drew W. R.; MacDonald, Stuart W. S.; Tanaka, James W.] Univ Victoria, Victoria, BC, Canada.
[Sherf, Suzanne K.] Penn State Univ, State Coll, PA USA.
[Halliday, Drew W. R.; Tanaka, James W.] Ctr Autism Res Technol & Educ, Victoria, BC, Canada.
RP Tanaka, JW (reprint author), Univ Victoria, Victoria, BC, Canada.
EM jtanaka@uvic.ca
FU Temporal Dynamics of Learning Center (NSF) [SBE-0542013]; National
Institute of Child Health and Human Development (NIH) [HD-46526];
Natural Sciences and Engineering Research
FX The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript. This research was
supported by grants from the Temporal Dynamics of Learning Center (NSF
Grant #SBE-0542013), National Institute of Child Health and Human
Development (NIH Grant HD-46526) and the Natural Sciences and
Engineering Research.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 1998, AUTISM, V2, P297
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Bate S, 2010, PERS INDIV DIFFER, V48, P239, DOI 10.1016/j.paid.2009.10.005
Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
DeGutis J, 2013, COGNITION, V126, P87, DOI 10.1016/j.cognition.2012.09.004
Dennett HW, 2012, BEHAV RES METHODS, V44, P587, DOI 10.3758/s13428-011-0160-2
Duchaine B, 2009, COGN NEUROPSYCHOL, V26, P620, DOI 10.1080/02643291003616145
Frith U, 1991, AUTISM ASPERGERS SYN
Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
Herlitz A, 1997, MEM COGNITION, V25, P801, DOI 10.3758/BF03211324
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P1, DOI DOI 10.1111/1469-7610.00142
Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
Lainhart JE, 2002, AM J MED GENET, V113, P231, DOI 10.1002/ajmg.10615
Li Jingguang, 2010, Commun Integr Biol, V3, P295
LORD C, 1982, J AUTISM DEV DISORD, V12, P317, DOI 10.1007/BF01538320
Lundqvist D., 1998, KAROLINSKA DIRECTED
Mars AE, 1998, J PEDIATR-US, V132, P500, DOI 10.1016/S0022-3476(98)70027-7
McGugin RW, 2012, VISION RES, V69, P10, DOI 10.1016/j.visres.2012.07.014
McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Pierce K, 2008, BIOL PSYCHIAT, V64, P552, DOI 10.1016/j.biopsych.2008.05.013
Rehnman J, 2007, ACTA PSYCHOL, V124, P344, DOI 10.1016/j.actpsy.2006.04.004
Rhodes G, 2013, NEUROPSYCHOLOGIA, V51, P2702, DOI [10.1016/j.neuropsychologia.2013.08.016, 10.1016/Lneuropsychologia.2013.08.016]
Scherf KS, 2008, J CHILD PSYCHOL PSYC, V49, P838, DOI 10.1111/j.1469-7610.2008.01903.x
Scherf KS, 2010, FRONT HUM NEUROSCI, V4, P1
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Serra M, 2003, J AUTISM DEV DISORD, V33, P303, DOI 10.1023/A:1024458618172
Spreen O., 1998, COMPENDIUM NEUROPSYC
Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
Tanaka JW, 2012, J CHILD PSYCHOL PSYC, V53, P1259, DOI 10.1111/j.1469-7610.2012.02571.x
Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
von dem Hagen EAH, 2011, CEREB CORTEX, V21, P493, DOI 10.1093/cercor/bhq062
Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
Yardley L, 2008, J PSYCHOSOM RES, V65, P445, DOI 10.1016/j.jpsychores.2008.03.013
NR 42
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 22
PY 2014
VL 9
IS 5
AR e94013
DI 10.1371/journal.pone.0094013
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK3KS
UT WOS:000338323200001
PM 24853862
ER
PT J
AU Kruizinga, I
Visser, JC
van Batenburg-Eddes, T
Carter, AS
Jansen, W
Raat, H
AF Kruizinga, Ingrid
Visser, Janne C.
van Batenburg-Eddes, Tamara
Carter, Alice S.
Jansen, Wilma
Raat, Hein
TI Screening for Autism Spectrum Disorders with the Brief Infant-Toddler
Social and Emotional Assessment
SO PLOS ONE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; TRAITS QUESTIONNAIRE ESAT;
PRESCHOOL-CHILDREN; ASSESSMENT BITSEA; ASSESSMENT ITSEA;
EARLY-CHILDHOOD; DIAGNOSIS; PREVALENCE; RELIABILITY; COMPETENCE
AB Objective: Using parent-completed questionnaires in (preventive) child health care can facilitate the early detection of psychosocial problems and psychopathology, including autism spectrum disorders (ASD). A promising questionnaire for this purpose is the Brief Infant-Toddler Social and Emotional Assessment (BITSEA). The screening accuracy with regard to ASD of the BITSEA Problem and Competence scales and a newly calculated Autism score were evaluated.
Method: Data, that was collected between April 2010 and April 2011, from a community sample of 2-year-olds (N = 3127), was combined with a sample of preschool children diagnosed with ASD (N = 159). For the total population and for subgroups by child's gender, area under the Receiver Operating Characteristic (ROC) curve was examined, and across a range of BITSEA Problem, Competence and Autism scores, sensitivity, specificity, positive and negative likelihood ratio's, diagnostic odds ratio and Youden's index were reported.
Results: The area under the ROC curve (95% confidence interval, [95%CI]) of the Problem scale was 0.90(0.87-0.92), of the Competence scale 0.93(0.91-0.95), and of the Autism score 0.95(0.93-0.97). For the total population, the screening accuracy of the Autism score was significantly better, compared to the Problem scale. The screening accuracy of the Competence scale was significantly better for girls (AUC = 0.97; 95%CI = 0.95-0.98) than for boys (AUC = 0.91; 95%CI = 0.88-0.94).
Conclusion: The results indicate that the BITSEA scales and newly calculated Autism score have good discriminative power to differentiate children with and without ASD. Therefore, the BITSEA may be helpful in the early detection of ASD, which could have beneficial effects on the child's development.
C1 [Kruizinga, Ingrid; Raat, Hein] Erasmus Univ, Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands.
[Visser, Janne C.] Karakter Univ, Ctr Nijmegen, Nijmegen, Netherlands.
[van Batenburg-Eddes, Tamara] Vrije Univ Amsterdam, Dept Psychol & Educ, Amsterdam, Netherlands.
[Carter, Alice S.] Univ Massachusetts, Dept Psychol, Boston, MA 02125 USA.
[Jansen, Wilma] Rotterdam Municipal Hlth Serv GGD Rotterdam Rijnm, Dept Youth Policy, Rotterdam, Netherlands.
RP Raat, H (reprint author), Erasmus Univ, Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands.
EM h.raat@erasmusmc.nl
FU ZonMw, The Netherlands Organization for Health Research and Development
[80-82435-98-8058]
FX This study is funded by a grant from the funding body ZonMw, The
Netherlands Organization for Health Research and Development
(www.zonmw.nl), project number: 80-82435-98-8058. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
Akobeng AK, 2007, ACTA PAEDIATR, V96, P644, DOI 10.1111/j.1651-2227.2006.00178.x
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
Bornstein MH, 2010, DEV PSYCHOPATHOL, V22, P717, DOI 10.1017/S0954579410000416
Briggs-Gowan M.J., 2002, BRIEF INFANT TODDLER
Briggs-Gowan MJ, 2004, J PEDIATR PSYCHOL, V29, P143, DOI 10.1093/jpepsy/jsh017
Briggs-Gowan MJ, 1998, INF MENTAL HLTH J, V19, P422, DOI 10.1002/(SICI)1097-0355(199824)19:4<422::AID-IMHJ5>3.0.CO;2-U
Briggs-Gowan MJ, 2006, J AM ACAD CHILD PSY, V45, P849, DOI 10.1097/01.chi.0000220849.48650.59
Briggs-Gowan MJ, 2008, PEDIATRICS, V121, P957, DOI 10.1542/peds.2007-1948
Carter AS, 2003, J ABNORM CHILD PSYCH, V31, P495, DOI 10.1023/A:1025449031360
Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Sandler AD, 2001, PEDIATRICS, V107, P1221
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
Egger HL, 2006, J CHILD PSYCHOL PSYC, V47, P313, DOI 10.1111/j.1469-7610.2006.01618.x
Filipek PA, 2000, NEUROLOGY, V55, P468
Fischer JE, 2003, INTENS CARE MED, V29, P1043, DOI 10.1007/s00134-003-1761-8
Haapsamo H, 2009, INT J CIRCUMPOL HEAL, V68, P386
Karabekiroglu K, 2010, INFANT BEHAV DEV, V33, P503, DOI 10.1016/j.infbeh.2010.07.001
Karabekiroglu K, 2009, INFANT BEHAV DEV, V32, P291, DOI 10.1016/j.infbeh.2009.03.003
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Kruizinga I, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072602
Kruizinga I, 2012, PLOS ONE, V7
Laurent de Angulo MS, 2005, ONTWIKKELING SONDERZ
Nunnally J. C., 1994, PSYCHOMETRIC THEORY
Oosterling IJ, 2009, J AUTISM DEV DISORD, V39, P897, DOI 10.1007/s10803-009-0692-9
Oosterling IJ, 2010, J CHILD PSYCHOL PSYC, V51, P250, DOI 10.1111/j.1469-7610.2009.02150.x
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Scheeringa MS, 2001, CHILD PSYCHIAT HUM D, V32, P71, DOI 10.1023/A:1017511714145
Seida JK, 2009, DEV MED CHILD NEUROL, V51, P95, DOI 10.1111/j.1469-8749.2008.03211.x
SWETS JA, 1988, SCIENCE, V240, P1285, DOI 10.1126/science.3287615
Swinkels SHN, 2006, J AUTISM DEV DISORD, V36, P723, DOI 10.1007/s10803-006-0115-0
Terwee CB, 2007, J CLIN EPIDEMIOL, V60, P34, DOI 10.1016/j.jclinepi.2006.03.012
Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
NR 37
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 22
PY 2014
VL 9
IS 5
AR e97630
DI 10.1371/journal.pone.0097630
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK3KS
UT WOS:000338323200025
PM 24851868
ER
PT J
AU Sherif, T
Rioux, P
Rousseau, ME
Kassis, N
Beck, N
Adalat, R
Das, S
Glatard, T
Evans, AC
AF Sherif, Tarek
Rioux, Pierre
Rousseau, Marc-Etienne
Kassis, Nicolas
Beck, Natacha
Adalat, Reza
Das, Samir
Glatard, Tristan
Evans, Alan C.
TI CBRAIN: a web-based, distributed computing platform for collaborative
neuroimaging research
SO FRONTIERS IN NEUROINFORMATICS
LA English
DT Article
DE eScience; distributed computing; meta-scheduler; collaborative platform;
interoperability; cloud computing; neuroimaging; visualization
ID IMAGE-ANALYSIS
AB The Canadian Brain Imaging Research Platform (CBRAIN) is a web-based collaborative research platform developed in response to the challenges raised by data-heavy, compute-intensive neuroimaging research. CBRAIN offers transparent access to remote data sources, distributed computing sites, and an array of processing and visualization tools within a controlled, secure environment. Its web interface is accessible through any modern browser and uses graphical interface idioms to reduce the technical expertise required to perform large-scale computational analyses. CBRAIN's flexible meta-scheduling has allowed the incorporation of a wide range of heterogeneous computing sites, currently including nine national research High Performance Computing (HPC) centers in Canada, one in Korea, one in Germany, and several local research servers. CBRAIN leverages remote computing cycles and facilitates resource-interoperability in a transparent manner for the end-user. Compared with typical grid solutions available, our architecture was designed to be easily extendable and deployed on existing remote computing sites with no tool modification, administrative intervention, or special software/hardware configuration. As October 2013, CBRAIN serves over 200 users spread across 53 cities in 17 countries. The platform is built as a generic framework that can accept data and analysis tools from any discipline. However, its current focus is primarily on neuroimaging research and studies of neurological diseases such as Autism, Parkinson's and Alzheimer's diseases, Multiple Sclerosis as well as on normal brain structure and development. This technical report presents the CBRAIN Platform, its current deployment and usage and future direction.
C1 [Sherif, Tarek; Rioux, Pierre; Rousseau, Marc-Etienne; Kassis, Nicolas; Beck, Natacha; Adalat, Reza; Das, Samir; Glatard, Tristan; Evans, Alan C.] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, ACElab, Montreal, PQ H3A 2B4, Canada.
[Glatard, Tristan] Univ Lyon, CNRS, INSERM, CREATIS, Lyon, France.
RP Evans, AC (reprint author), McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, ACElab, 3801 Univ St,Webster 2B 208, Montreal, PQ H3A 2B4, Canada.
EM alan.evans@mcgill.ca
RI Glatard, Tristan/H-3656-2014
FU CANARIE; Canada's Advanced Research and Innovation Network; McGill
University; Compute Canada
FX This work has been funded by CANARIE, Canada's Advanced Research and
Innovation Network (http://www.canarie.ca) and McGill University. We are
grateful for the computing cycles, storage, and support obtained from
Compute Canada (https:// computecanada.ca) and our collaborators at
KISTI (Korea) and at the Julich Supercomputing Centre (Germany). In
addition to the authors, we would like to thank Mathieu Desrosiers for
contributing sustained development efforts and site project
coordination.
CR Amunts K, 2013, SCIENCE, V340, P1472, DOI 10.1126/science.1235381
Andreetto P, 2010, J GRID COMPUT, V8, P19, DOI 10.1007/s10723-010-9146-z
Andreetto P, 2008, Journal of Physics: Conference Series, DOI 10.1088/1742-6596/119/6/062007
Antoniu G., 2012, ERCIM NEWS, V89, P21
Bachle M, 2007, IEEE SOFTWARE, V24, P105, DOI 10.1109/MS.2007.176
Barbera R, 2009, BMC BIOINFORMATICS, V10, DOI 10.1186/1471-2105-10-S6-S21
Baud J.-P., 2005, IEEE INT S HIGH PERF, P91, DOI [10.1109/HPDC.2005.1520941, DOI 10.1109/HPDC.2005.1520941]
Bell G, 2009, SCIENCE, V323, P1297, DOI 10.1126/science.1170411
Brook N., 2003, P COMP HIGH EN NUCL, P1
Buetow KH, 2005, SCIENCE, V308, P821, DOI 10.1126/science.1112120
Catlett C., 2002, Proceedings CCGRID 2002. 2nd IEEE/ACM International Symposium on Cluster Computing and the Grid, DOI 10.1109/CCGRID.2002.1017101
Chervenak AL, 2009, IEEE T PARALL DISTR, V20, P1260, DOI 10.1109/TPDS.2008.151
Costan A., 2013, CONCUR COMPUT PRACT, DOI [10.1002/cpe.3034, DOI 10.1002/CPE.3034]
Das Samir, 2011, Front Neuroinform, V5, P37, DOI 10.3389/fninf.2011.00037
Dinov I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013070
Dinov Ivo D, 2009, Front Neuroinform, V3, P22, DOI 10.3389/neuro.11.022.2009
Ellert M, 2007, FUTURE GENER COMP SY, V23, P219, DOI 10.1016/j.future.2006.05.008
Foster I., 1998, CCS 98 P 5 ACM C COM, P83, DOI [DOI 10.1145/288090.288111, 10.1145/288090.288111]
Foster I., 2003, GRID 2 BLUEPRINT NEW
Frey J., 2002, Cluster Computing, V5, DOI 10.1023/A:1015617019423
Frisoni GB, 2011, NAT REV NEUROL, V7, P429, DOI 10.1038/nrneurol.2011.99
Glatard T, 2013, IEEE T MED IMAGING, V32, P110, DOI 10.1109/TMI.2012.2220154
Gorgolewski Krzysztof, 2011, Front Neuroinform, V5, P13, DOI 10.3389/fninf.2011.00013
Gronenschild EHBM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038234
Huedo E., 2001, SCAL COMP PRACT EXP, V6, P1, DOI 10.12694/scpe.v6i3.332
Jenkinson M, 2012, NEUROIMAGE, V62, P782, DOI 10.1016/j.neuroimage.2011.09.015
JHA S, 2007, IEEE COMPUTER SOCIET, P584, DOI DOI 10.1109/E-SCIENCE.2007.47
Joshi A, 2011, NEUROINFORMATICS, V9, P69, DOI 10.1007/s12021-010-9092-8
Kacsuk P, 2012, J GRID COMPUT, V10, P601, DOI 10.1007/s10723-012-9240-5
Karama S., 2013, MOL PSYCHIATR, V19, P555, DOI [10.1038/mp.2013.64, DOI 10.1038/MP.2013.64]
Kim JS, 2005, NEUROIMAGE, V27, P210, DOI 10.1016/j.neuroimage.2005.03.036
Kranzlmuller D., 2010, REMOTE INSTRUMENTATI, P61, DOI [10.1007/978-1-4419-5597-5_6, DOI 10.1007/978-1-4419-5597-5_6]
Lavoie-Courchesne S, 2012, J PHYS CONF SER, V341, DOI 10.1088/1742-6596/341/1/012032
Lerch JP, 2006, NEUROIMAGE, V31, P993, DOI 10.1016/j.neuroimage.2006.01.042
MacKenzie-Graham AJ, 2008, NEUROIMAGE, V42, P178, DOI 10.1016/j.neuroimage.2008.04.186
Markram Henry, 2013, Funct Neurol, V28, P145, DOI 10.11138/FNeur/2013.28.3.144
Marru S., 2011, P ACM, V21, P21, DOI [10.1145/2110486.2110490, DOI 10.1145/2110486.2110490]
Olabarriaga SD, 2010, IEEE T INF TECHNOL B, V14, P979, DOI 10.1109/TITB.2010.2046742
PARK SM, 2008, IEEE INT S PAR DISTR, P1796, DOI DOI 10.1109/IPDPS.2008.4536306
Pordes Ruth, 2007, J PHYS C SER, V78, DOI DOI 10.1088/1742-6596/78/1/012057
Redolfi A, 2009, FUTURE NEUROL, V4, P703, DOI DOI 10.2217/FNL.09.53
Reuter M, 2012, NEUROIMAGE, V61, P1402, DOI 10.1016/j.neuroimage.2012.02.084
Rex DE, 2003, NEUROIMAGE, V19, P1033, DOI 10.1016/S1053-8119(03)00185-X
Troger P., 2007, 7 IEEE INT S CLUST C, P619, DOI [10.1109/CCGRID.2007.109, DOI 10.1109/CCGRID.2007.109]
Van Horn JD, 2014, BRAIN IMAGING BEHAV, V8, P323, DOI 10.1007/s11682-013-9255-y
NR 45
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5196
J9 FRONT NEUROINFORM
JI Front. Neuroinformatics
PD MAY 21
PY 2014
VL 8
AR 54
DI 10.3389/fninf.2014.00054
PG 13
WC Mathematical & Computational Biology; Neurosciences
SC Mathematical & Computational Biology; Neurosciences & Neurology
GA AZ3EZ
UT WOS:000348111700001
PM 24904400
ER
PT J
AU Takata, A
Xu, B
Ionita-Laza, I
Roos, JL
Gogos, JA
Karayiorgou, M
AF Takata, Atsushi
Xu, Bin
Ionita-Laza, Iuliana
Roos, J. Louw
Gogos, Joseph A.
Karayiorgou, Maria
TI Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a
Candidate Susceptibility Gene
SO NEURON
LA English
DT Article
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; INTELLECTUAL DISABILITY;
HISTONE METHYLATION; SEQUENCING DATA; SET1 COMPLEX; PROTEIN; GENOME;
ASSOCIATION; CHROMATIN
AB Loss-of-function (LOF) (i.e., nonsense, splice site, and frameshift) variants that lead to disruption of gene function are likely to contribute to the etiology of neuropsychiatric disorders. Here, we perform a systematic investigation of the role of both de novo and inherited LOF variants in schizophrenia using exome sequencing data from 231 case and 34 control trios. We identify two de novo LOF variants in the SETD1A gene, which encodes a subunit of histone methyltransferase, a finding unlikely to have occurred by chance, and provide evidence for a more general role of chromatin regulators in schizophrenia risk. Transmission pattern analyses reveal that LOF variants are more likely to be transmitted to affected individuals than controls. This is especially true for private LOF variants in genes intolerant to functional genetic variation. These findings highlight the contribution of LOF mutations to the genetic architecture of schizophrenia and provide important insights into disease pathogenesis.
C1 [Takata, Atsushi; Xu, Bin; Karayiorgou, Maria] Columbia Univ, Med Ctr, Dept Psychiat, New York, NY 10032 USA.
[Ionita-Laza, Iuliana] Columbia Univ, Med Ctr, Dept Biostat, New York, NY 10032 USA.
[Roos, J. Louw] Univ Pretoria, Dept Psychiat, Weskoppies Hosp, ZA-0001 Pretoria, South Africa.
[Gogos, Joseph A.] Columbia Univ, Med Ctr, Dept Neurosci, New York, NY 10032 USA.
[Gogos, Joseph A.] Columbia Univ, Med Ctr, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
[Karayiorgou, Maria] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
RP Gogos, JA (reprint author), Columbia Univ, Med Ctr, Dept Neurosci, New York, NY 10032 USA.
EM jag90@columbia.edu; mk2758@columbia.edu
FU National Institute of Mental Health (NIMH) [MH061399, MH097879]; Lieber
Center for Schizophrenia Research at Columbia University; JSPS; National
Alliance for Research in Schizophrenia and Depression (NARSAD)
FX We are grateful to all the families who participated in this research.
We thank S. L. Lundy for valuable assistance with clinical database
maintenance. We also thank S. Levy and the HudsonAlpha Genomics Services
Laboratory for sequencing. This work was partially supported by National
Institute of Mental Health (NIMH) grants MH061399 (to M. K.) and
MH097879 (to J.A.G.) and the Lieber Center for Schizophrenia Research at
Columbia University. A. T. was supported by the JSPS Postdoctoral
Fellowship for Research Abroad. B. X. was partially supported by a
National Alliance for Research in Schizophrenia and Depression (NARSAD)
Young Investigator Award.
CR Altshuler DM, 2012, NATURE, V491, P56, DOI 10.1038/nature11632
Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
Albers CA, 2011, GENOME RES, V21, P961, DOI 10.1101/gr.112326.110
Ben-David E, 2013, MOL PSYCHIATR, V18, P1054, DOI 10.1038/mp.2012.148
Bottas A, 2005, J PSYCHIATR NEUROSCI, V30, P187
Cingolani P, 2012, FLY, V6, P80, DOI 10.4161/fly.19695
Crow JF, 2000, NAT REV GENET, V1, P40, DOI 10.1038/35049558
Dehe PM, 2006, J BIOL CHEM, V281, P35404, DOI 10.1074/jbc.M603099200
de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
EDMONDS DK, 1982, FERTIL STERIL, V38, P447
Gilman SR, 2012, NAT NEUROSCI, V15, P1723, DOI 10.1038/nn.3261
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Goriely A, 2013, AM J PSYCHIAT, V170, P599, DOI 10.1176/appi.ajp.2013.12101352
Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
Gupta S, 2010, J NEUROSCI, V30, P3589, DOI 10.1523/JNEUROSCI.3732-09.2010
He X, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003671
Hu X., 2013, MOL PSYCHIAT
Huang HS, 2007, J NEUROSCI, V27, P11254, DOI 10.1523/JNEUROSCI.3272-07.2007
Huang W., 2009, NAT PROTOC, V4, P44, DOI DOI 10.1038/NPR0T.2008.211
Ionita-Laza I, 2014, P NATL ACAD SCI USA, V111, P343, DOI 10.1073/pnas.1309475110
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jensen LR, 2005, AM J HUM GENET, V76, P227, DOI 10.1086/427563
Jiang Y, 2012, BIOINFORMATICS, V28, P2576, DOI 10.1093/bioinformatics/bts484
Karayiorgou M, 2012, NAT NEUROSCI, V15, P811, DOI 10.1038/nn.3115
Karayiorgou Maria, 1995, Proceedings of the National Academy of Sciences of the United States of America, V92, P7612, DOI 10.1073/pnas.92.17.7612
Kenny E. M., 2013, MOL PSYCHIAT
Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
Merla G, 2010, HUM GENET, V128, P3, DOI 10.1007/s00439-010-0827-2
Mohan M, 2010, NAT REV CANCER, V10, P720, DOI 10.1038/nrc2915
Mukai J, 2008, NAT NEUROSCI, V11, P1302, DOI 10.1038/nn.2204
Nacak TG, 2006, J BIOL CHEM, V281, P5065, DOI 10.1074/jbc.M509073200
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Otto SP, 1998, GENETICA, V102-3, P507, DOI 10.1023/A:1017074823337
Petrovski S, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003709
Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Robinson JT, 2011, NAT BIOTECHNOL, V29, P24, DOI 10.1038/nbt.1754
Rodriguez-Murillo L, 2012, ANNU REV MED, V63, P63, DOI 10.1146/annurev-med-072010-091100
Roguev A, 2001, EMBO J, V20, P7137, DOI 10.1093/emboj/20.24.7137
Ronan JL, 2013, NAT REV GENET, V14, P347, DOI 10.1038/nrg3413
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schlichter A, 2005, EMBO J, V24, P1222, DOI 10.1038/sj.emboj.7600607
Shilatifard A, 2012, ANNU REV BIOCHEM, V81, P65, DOI 10.1146/annurev-biochem-051710-134100
Shulha HP, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003433
Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
Wynder C, 2005, NAT CELL BIOL, V7, P1113, DOI 10.1038/ncb1312
Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
Xu B, 2013, CELL, V152, P262, DOI 10.1016/j.cell.2012.11.052
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
Yates JA, 2010, FEBS LETT, V584, P689, DOI 10.1016/j.febslet.2010.01.022
Ye K, 2009, BIOINFORMATICS, V25, P2865, DOI 10.1093/bioinformatics/btp394
Zhu QQ, 2011, AM J HUM GENET, V88, P458, DOI 10.1016/j.ajhg.2011.03.008
NR 59
TC 6
Z9 7
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD MAY 21
PY 2014
VL 82
IS 4
BP 773
EP 780
DI 10.1016/j.neuron.2014.04.043
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA AH8IA
UT WOS:000336379800008
PM 24853937
ER
PT J
AU Kumamaru, E
Egashira, Y
Takenaka, R
Takamori, S
AF Kumamaru, Emi
Egashira, Yoshihiro
Takenaka, Rie
Takamori, Shigeo
TI Valproic acid selectively suppresses the formation of inhibitory
synapses in cultured cortical neurons
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Valproic acid; Vesicular GABA transporter; Synapse formation
ID HISTONE DEACETYLASE; NEOCORTICAL CIRCUITS; VESICULAR GLUTAMATE; MOOD
STABILIZER; AUTISM; GABA; BRAIN; MICE; MODEL; DIFFERENTIATION
AB Valproic acid (VPA) has been used to treat epileptic patients because of its ability to potentiate GABA signaling in the brain. Despite its clinical significance, VPA administration during pregnancy increases the risk of congenital abnormalities, such as neural tube defects and neurodevelopmental disorders including autism. Furthermore, recent studies revealed that early postnatal administration of VPA also leads to neurodevelopmental deficits in rodents. Here, using cultured cortical neurons derived from postnatal day 1 rats, we examined whether exposure to VPA would affect synapse formation. When neurons were exposed to 1 mM VPA during early development, expression of the vesicular GABA transporter (VGAT) was selectively reduced, whereas other synaptic markers, including the vesicular glutamate transporters 1 and 2 (VGLUT1 and 2), were not affected. This VPA effect was mediated through inhibition of histone deacetylases (HDACs), since the effects were mostly recapitulated by an HDAC inhibitor, trichostatin A, but not by a VPA derivative, valpromide, which lacks HDAC inhibitor activity. Immunocytochemical analysis demonstrated that VPA exposure resulted in a retardation of axonal growth specific to GABAergic neurons and a decrease in VGAT-positive synapses. Since disturbance of the excitatory and inhibitory (E-I) balance has been implicated as a potential cause of multiple psychiatric disorders, our results may account for one of the cellular mechanisms underlying the pathogenesis of VPA-induced neurodevelopmental impairments. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Kumamaru, Emi; Egashira, Yoshihiro; Takenaka, Rie; Takamori, Shigeo] Doshisha Univ, Grad Sch Brain Sci, Lab Neural Membrane Biol, Kyotanabe, Kyoto 6100394, Japan.
RP Kumamaru, E (reprint author), Doshisha Univ, Grad Sch Brain Sci, Lab Neural Membrane Biol, 1-3 Miyakodani, Kyotanabe, Kyoto 6100394, Japan.
EM ekumamar@mail.doshisha.ac.jp; yegashir@mail.doshisha.ac.jp;
rie1989ta@yahoo.co.jp; stakamor@mail.doshisha.ac.jp
CR Akerman CJ, 2007, TRENDS NEUROSCI, V30, P382, DOI 10.1016/j.tins.2007.06.002
Banerjee A, 2013, INT J NEUROPSYCHOPH, V16, P1309, DOI 10.1017/S1461145712001216
Ben-Ari Y, 2006, EPILEPTIC DISORD, V8, P91
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
CHRISTIANSON AL, 1994, DEV MED CHILD NEUROL, V36, P361
Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
COLLINS RM, 1994, J NEUROCHEM, V62, P1137
Cowan W.M., 2001, SYNAPSES SYNAPSE FOR, P571
Coyle JT, 2003, NEURON, V38, P157, DOI 10.1016/S0896-6273(03)00195-8
De Gois S, 2005, J NEUROSCI, V25, P7121, DOI 10.1523/JNEUROSCI.5221-04.2005
Deng L, 2007, J NEUROSCI, V27, P10860, DOI 10.1523/JNEUROSCI.2744-07.2007
Fukuchi M, 2009, NEUROSCI RES, V65, P35, DOI 10.1016/j.neures.2009.05.002
Gottmann K, 2009, EXP BRAIN RES, V199, P203, DOI 10.1007/s00221-009-1994-z
Hao YL, 2004, J NEUROSCI, V24, P6590, DOI 10.1523/JNEUROSCI.5747-03.2004
Hensch TK, 2005, NAT REV NEUROSCI, V6, P877, DOI 10.1038/nrn1787
Hsieh J, 2004, P NATL ACAD SCI USA, V101, P16659, DOI 10.1073/pnas.0407643101
Huang ZJ, 2009, J PHYSIOL-LONDON, V587, P1881, DOI 10.1113/jphysiol.2008.168211
Kataoka S, 2013, INT J NEUROPSYCHOPH, V16, P91, DOI 10.1017/S1461145711001714
LARSSON OM, 1986, NEUROPHARMACOLOGY, V25, P617, DOI 10.1016/0028-3908(86)90214-5
LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
Lewis DA, 2008, NEUROPSYCHOPHARMACOL, V33, P141, DOI 10.1038/sj.npp.1301563
Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
McCormick DA, 2001, ANNU REV PHYSIOL, V63, P815, DOI 10.1146/annurev.physiol.63.1.815
Moldrich RX, 2013, BEHAV BRAIN RES, V257, P253, DOI 10.1016/j.bbr.2013.09.049
Numakawa T, 2002, J BIOL CHEM, V277, P6520, DOI 10.1074/jbc.M109139200
Ornoy A, 2009, REPROD TOXICOL, V28, P1, DOI 10.1016/j.reprotox.2009.02.014
Phiel CJ, 2001, J BIOL CHEM, V276, P36734, DOI 10.1074/jbc.M101287200
Ramamoorthi K, 2011, TRENDS MOL MED, V17, P452, DOI 10.1016/j.molmed.2011.03.003
Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
Rinaldi T, 2008, CEREB CORTEX, V18, P763, DOI 10.1093/cercor/bhm117
Takamori S, 2000, J NEUROSCI, V20, P4904
Takamori S, 2001, J NEUROSCI, V21
Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y
Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
Yochum CL, 2008, BRAIN RES, V1203, P126, DOI 10.1016/j.brainres.2008.01.055
NR 35
TC 1
Z9 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 21
PY 2014
VL 569
BP 142
EP 147
DI 10.1016/j.neulet.2014.03.066
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA AH8AI
UT WOS:000336356100028
PM 24708928
ER
PT J
AU Buxbaum, JD
Bolshakova, N
Brownfeld, JM
Anney, RJL
Bender, P
Bernier, R
Cook, EH
Coon, H
Cuccaro, M
Freitag, CM
Hallmayer, J
Geschwind, D
Klauck, SM
Nurnberger, JI
Oliveira, G
Pinto, D
Poustka, F
Scherer, SW
Shih, A
Sutcliffe, JS
Szatmari, P
Vicente, AM
Vieland, V
Gallagher, L
AF Buxbaum, Joseph D.
Bolshakova, Nadia
Brownfeld, Jessica M.
Anney, Richard J. L.
Bender, Patrick
Bernier, Raphael
Cook, Edwin H.
Coon, Hilary
Cuccaro, Michael
Freitag, Christine M.
Hallmayer, Joachim
Geschwind, Daniel
Klauck, Sabine M.
Nurnberger, John I.
Oliveira, Guiomar
Pinto, Dalila
Poustka, Fritz
Scherer, Stephen W.
Shih, Andy
Sutcliffe, James S.
Szatmari, Peter
Vicente, Astrid M.
Vieland, Veronica
Gallagher, Louise
TI The Autism Simplex Collection: an international, expertly phenotyped
autism sample for genetic and phenotypic analyses
SO MOLECULAR AUTISM
LA English
DT Article
ID DE-NOVO MUTATIONS; COPY NUMBER VARIATION; SPECTRUM DISORDERS;
COMMUNICATION CHECKLIST; GENOME; INDIVIDUALS; SCALE; RISK;
IDENTIFICATION; VALIDATION
AB Background: There is an urgent need for expanding and enhancing autism spectrum disorder (ASD) samples, in order to better understand causes of ASD.
Methods: In a unique public-private partnership, 13 sites with extensive experience in both the assessment and diagnosis of ASD embarked on an ambitious, 2-year programto collect samples for genetic and phenotypic research and begin analyses on these samples. The program was called The Autism Simplex Collection (TASC). TASC sample collection began in 2008 and was completed in 2010, and included nine sites from North America and four sites from Western Europe, as well as a centralized Data Coordinating Center.
Results: Over 1,700 trios are part of this collection, with DNA from transformed cells now available through the National Institute of Mental Health (NIMH). Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule-Generic (ADOS-G) measures are available for all probands, as are standardized IQ measures, Vineland Adaptive Behavioral Scales (VABS), the Social Responsiveness Scale (SRS), Peabody Picture Vocabulary Test (PPVT), and physical measures (height, weight, and head circumference). At almost every site, additional phenotypic measures were collected, including the Broad Autism Phenotype Questionnaire (BAPQ) and Repetitive Behavior Scale-Revised (RBS-R), as well as the non-word repetition scale, Communication Checklist (Children's or Adult), and Aberrant Behavior Checklist (ABC). Moreover, for nearly 1,000 trios, the Autism Genome Project Consortium (AGP) has carried out Illumina 1 M SNP genotyping and called copy number variation (CNV) in the samples, with data being made available through the National Institutes of Health (NIH). Whole exome sequencing (WES) has been carried out in over 500 probands, together with ancestry matched controls, and this data is also available through the NIH. Additional WES is being carried out by the Autism Sequencing Consortium (ASC), where the focus is on sequencing complete trios. ASC sequencing for the first 1,000 samples (all from whole-blood DNA) is complete and data will be released in 2014. Data is being made available through NIH databases (database of Genotypes and Phenotypes (dbGaP) and National Database for Autism Research (NDAR)) with DNA released in Dist 11.0. Primary funding for the collection, genotyping, sequencing and distribution of TASC samples was provided by Autism Speaks and the NIH, including the National Institute of Mental Health (NIMH) and the National Human Genetics Research Institute (NHGRI).
Conclusions: TASC represents an important sample set that leverages expert sites. Similar approaches, leveraging expert sites and ongoing studies, represent an important path towards further enhancing available ASD samples.
C1 [Buxbaum, Joseph D.; Brownfeld, Jessica M.; Pinto, Dalila] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Dept Psychiat, New York, NY 10029 USA.
[Bolshakova, Nadia; Anney, Richard J. L.; Gallagher, Louise] Autism Genet Grp, Sch Med, Dept Psychiat, Trin Coll, Dublin 8, Ireland.
[Bender, Patrick] NIMH, Bethesda, MD 20892 USA.
[Bernier, Raphael] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Cook, Edwin H.] Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL 60608 USA.
[Coon, Hilary] Univ Utah, Dept Psychiat, Sch Med, Salt Lake City, UT 84108 USA.
[Cuccaro, Michael] Univ Miami, John P Hussman Inst Human Genom, Miami, FL 33101 USA.
[Freitag, Christine M.; Poustka, Fritz] JW Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
[Hallmayer, Joachim] Stanford Sch Med, Dept Psychiat & Behav Sci Child & Adolescent Psyc, Stanford, CA USA.
[Geschwind, Daniel] Univ Calif Los Angeles, Dept Neurol, Sch Med, Los Angeles, CA 90095 USA.
[Klauck, Sabine M.] German Canc Res Ctr, D-69120 Heidelberg, Germany.
[Nurnberger, John I.] Indiana Univ, Dept Psychiat, Sch Med, Indianapolis, IN 46202 USA.
[Oliveira, Guiomar] Ctr Hosp, Unidade Neurodesenvolvimento & Autismo, Serv Ctr Desenvolvimento Crianca, P-3000602 Coimbra, Portugal.
[Oliveira, Guiomar] Ctr Hosp, Ctr Invest & Form Clin, Pediat Hosp, P-3000602 Coimbra, Portugal.
[Oliveira, Guiomar] Univ Coimbra, P-3000602 Coimbra, Portugal.
[Oliveira, Guiomar] Univ Clin Pediat, P-3000602 Coimbra, Portugal.
[Oliveira, Guiomar] Univ Coimbra, Inst Biomed Imaging & Life Sci, Fac Med, P-3000602 Coimbra, Portugal.
[Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Dept Mol Genet, Toronto, ON M5G 1X8, Canada.
[Scherer, Stephen W.] McLaughlin Ctr, Toronto, ON M5G 1X8, Canada.
[Scherer, Stephen W.] Univ Toronto, Toronto, ON M5G 1X8, Canada.
[Shih, Andy] Autism Speaks, New York, NY 10016 USA.
[Sutcliffe, James S.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Vanderbilt Kennedy Ctr, Nashville, TN 37232 USA.
[Sutcliffe, James S.] Vanderbilt Univ, Ctr Human Genet Res & Mol Neurosci, Nashville, TN 37232 USA.
[Szatmari, Peter] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8N 3Z5, Canada.
[Vicente, Astrid M.] Inst Nacl Saude Dr Ricardo Jorge, P-1649016 Lisbon, Portugal.
[Vicente, Astrid M.] Inst Gulbenkian Ciencias, P-2781901 Oeiras, Portugal.
[Vicente, Astrid M.] BioFIG Ctr Biodivers Funct & Integrat Genom, P-1749016 Lisbon, Portugal.
[Vieland, Veronica] Ohio State Univ, Res Inst, Nationwide Childrens Hosp, Columbus, OH 43210 USA.
RP Buxbaum, JD (reprint author), Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Dept Psychiat, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu; lgallagh@tcd.ie
RI Scherer, Stephen /B-3785-2013; Sutcliffe, James/C-1348-2012
OI Scherer, Stephen /0000-0002-8326-1999; Sutcliffe,
James/0000-0001-5200-6007
FU National Institutes of Health [MH094303, MH100233]
FX The TASC consortium collection and genotyping was supported by Autism
Speaks. Funding for the sequencing and distribution of TASC samples was
provided by the National Institutes of Health (MH094303 and MH100233).
We thank Dr. Bernie Devlin for thoughtful comments on the manuscript.
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
[Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Buxbaum JD, 2012, NEURON, V76, P1052, DOI 10.1016/j.neuron.2012.12.008
Constantino JN, 2002, PSYCHOL SERVICES
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Devlin B, 2011, BRAIN RES, V1380, P78, DOI 10.1016/j.brainres.2010.11.026
Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
He X, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003671
Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246
Krumm N, 2013, AM J HUM GENET, V93, P595, DOI 10.1016/j.ajhg.2013.07.024
Lajonchere CM, 2010, NEURON, V68, P187, DOI 10.1016/j.neuron.2010.10.009
Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
Liu L, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003443
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Merikangas AK, 2009, TRENDS GENET, V25, P536, DOI 10.1016/j.tig.2009.10.006
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Norbury CF, 2004, INT J LANG COMM DIS, V39, P345, DOI 10.1080/13682820410001654883
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Poultney CS, 2013, AM J HUM GENET, V93, P607, DOI 10.1016/j.ajhg.2013.09.001
Psychiatric GCCC, 2009, AM J PSYCHIAT, V166, P540
Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stankiewicz P, 2010, ANNU REV MED, V61, P437, DOI 10.1146/annurev-med-100708-204735
Sullivan PF, 2008, CURR OPIN PSYCHIATR, V21, P157, DOI 10.1097/YCO.0b013e3282f4efde
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
Wagner R., 1999, COMPREHENSIVE TEST P
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Whitehouse AJO, 2010, AUTISM, V14, P559, DOI 10.1177/1362361310382107
Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
NR 43
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 20
PY 2014
VL 5
AR 34
DI 10.1186/2040-2392-5-34
PG 8
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CC6BL
UT WOS:000350449400001
PM 25392729
ER
PT J
AU Ahtola, E
Stjerna, S
Yrttiaho, S
Nelson, CA
Leppanen, JM
Vanhatalo, S
AF Ahtola, Eero
Stjerna, Susanna
Yrttiaho, Santeri
Nelson, Charles A.
Leppanen, Jukka M.
Vanhatalo, Sampsa
TI Dynamic Eye Tracking Based Metrics for Infant Gaze Patterns in the
Face-Distractor Competition Paradigm
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; 7-MONTH-OLD INFANTS; VISUAL-ATTENTION;
FEARFUL FACES; COGNITIVE-DEVELOPMENT; DISENGAGEMENT; CHILDREN; DURATION;
BEHAVIOR; LOOKING
AB Objective: To develop new standardized eye tracking based measures and metrics for infants' gaze dynamics in the face-distractor competition paradigm.
Method: Eye tracking data were collected from two samples of healthy 7-month-old (total n = 45), as well as one sample of 5-month-old infants (n = 22) in a paradigm with a picture of a face or a non-face pattern as a central stimulus, and a geometric shape as a lateral stimulus. The data were analyzed by using conventional measures of infants' initial disengagement from the central to the lateral stimulus (i.e., saccadic reaction time and probability) and, additionally, novel measures reflecting infants gaze dynamics after the initial disengagement (i.e., cumulative allocation of attention to the central vs. peripheral stimulus).
Results: The results showed that the initial saccade away from the centrally presented stimulus is followed by a rapid re-engagement of attention with the central stimulus, leading to cumulative preference for the central stimulus over the lateral stimulus over time. This pattern tended to be stronger for salient facial expressions as compared to non-face patterns, was replicable across two independent samples of 7-month-old infants, and differentiated between 7 and 5 month-old infants.
Conclusion: The results suggest that eye tracking based assessments of infants' cumulative preference for faces over time can be readily parameterized and standardized, and may provide valuable techniques for future studies examining normative developmental changes in preference for social signals.
Significance: Standardized measures of early developing face preferences may have potential to become surrogate biomarkers of neurocognitive and social development.
C1 [Ahtola, Eero; Stjerna, Susanna; Vanhatalo, Sampsa] Univ Helsinki, Cent Hosp, Dept Childrens Clin Neurophysiol, Helsinki, Finland.
[Ahtola, Eero] Aalto Univ, Dept Biomed Engn & Computat Sci, Helsinki, Finland.
[Yrttiaho, Santeri; Leppanen, Jukka M.] Univ Tampere, Infant Cognit Lab, Tampere Ctr Child Hlth Res, FIN-33101 Tampere, Finland.
[Nelson, Charles A.] Childrens Hosp, Labs Cognit Neurosci, Boston, MA 02115 USA.
[Nelson, Charles A.] Harvard Univ, Sch Med, Boston, MA USA.
[Vanhatalo, Sampsa] Univ Helsinki, Dept Neurol Sci, Helsinki, Finland.
RP Ahtola, E (reprint author), Univ Helsinki, Cent Hosp, Dept Childrens Clin Neurophysiol, Helsinki, Finland.
EM eero.ahtola@hus.fi
FU Helsinki University Hospital; Juselius Foundation; Paivi and Sakari
Sohlberg Foundation; Academy of Finland [218284]; European Community
[FP7-PEOPLE-2009-IOF, 254235, 283763]
FX This work was supported by Helsinki University Hospital, Juselius
Foundation, Paivi and Sakari Sohlberg Foundation, Academy of Finland
(#218284 and 218284), as well as the European Community's Seventh
Framework Programme (FP7-PEOPLE-2009-IOF, grant agreements #254235 and
#283763). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
CR ASLIN RN, 1975, PERCEPT PSYCHOPHYS, V17, P293, DOI 10.3758/BF03203214
Blaga OA, 2006, DEV PSYCHOL, V42, P1069, DOI 10.1037/0012-1649-42.6.1069
Carpenter M., 1998, MONOGR SOC RES CHILD, V63, P1, DOI DOI 10.2307/1166214
Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755
Csibra G, 1998, INT J PSYCHOPHYSIOL, V29, P201, DOI 10.1016/S0167-8760(98)00016-6
Eastwood JD, 2008, VIS COGN, V16, P248, DOI 10.1080/13506280701434383
Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x
Fletcher-Watson S, 2008, PERCEPTION, V37, P571, DOI 10.1068/p5705
Forssman L, 2013, J CHILD PSYCHOL PSYC
Frank MC, 2009, COGNITION, V110, P160, DOI 10.1016/j.cognition.2008.11.010
Frank MC, 2012, INFANCY, V17, P355, DOI 10.1111/j.1532-7078.2011.00086.x
Frischen A, 2008, PSYCHOL BULL, V134, P662, DOI 10.1037/0033-2909.134.5.662
Gredeback G, 2010, DEV NEUROPSYCHOL, V35, P1, DOI 10.1080/87565640903325758
Green CR, 2009, EUR J NEUROSCI, V29, P1302, DOI 10.1111/j.1460-9568.2009.06668.x
Hershler O, 2005, VISION RES, V45, P1707, DOI 10.1016/j.visres.2004.12.021
Holmboe K, 2008, J EXP CHILD PSYCHOL, V100, P89, DOI 10.1016/j.jecp.2007.09.004
Hunnius S, 2006, INFANT BEHAV DEV, V29, P108, DOI 10.1016/j.infbeh.2005.08.007
Hunnius S, 2008, DEV NEUROPSYCHOL, V33, P521, DOI 10.1080/87565640802101508
Hunnius S, 2007, PROG BRAIN RES, V164, P187, DOI 10.1016/S0079-6123(07)64010-2
Isler JR, 2012, DEVELOPMENTAL SCI, V15, P260, DOI 10.1111/j.1467-7687.2011.01122.x
Johnson MH, 2005, NAT REV NEUROSCI, V6, P766, DOI 10.1038/nrn1766
JOHNSON MH, 1991, J COGNITIVE NEUROSCI, V3, P335, DOI 10.1162/jocn.1991.3.4.335
Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
Leppanen J, 2010, INT J BEHAV DEV, V34, P547, DOI 10.1177/0165025410365804
Leppanen JM, BEHAV RES METHODS
Leppanen JM, 2011, J CHILD PSYCHOL PSYC, V52, P1144, DOI 10.1111/j.1469-7610.2011.02391.x
Matsuzawa M, 1997, INFANT BEHAV DEV, V20, P449, DOI 10.1016/S0163-6383(97)90035-7
McEwen BS, 2012, P NATL ACAD SCI USA, V109, P17180, DOI 10.1073/pnas.1121254109
Morgante JD, 2012, INFANCY, V17, P9, DOI 10.1111/j.1532-7078.2011.00089.x
Nakano T, 2010, P ROY SOC B-BIOL SCI, V277, P2935, DOI 10.1098/rspb.2010.0587
Peltola MJ, 2013, INFANCY, V18, P905, DOI 10.1111/infa.12013
Peltola MJ, 2008, DEVELOPMENTAL SCI, V11, P60, DOI 10.1111/j.1467-7687.2007.00659.x
Peltola MJ, 2011, PSYCHOPHYSIOLOGY, V48, P1291, DOI 10.1111/j.1469-8986.2011.01188.x
Peltola MJ, 2009, EMOTION, V9, P560, DOI 10.1037/a0015806
Perez-Edgar K, 2010, DEV PSYCHOL, V46, P1723, DOI 10.1037/a0021064
Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
Richmond J, 2009, DEVELOPMENTAL SCI, V12, P549, DOI 10.1111/j.1467-7687.2009.00795.x
Ro T, 2007, VIS COGN, V15, P322, DOI 10.1080/13506280600590434
Shic F, 2008, WASH DC 30 ANN M COG
Shic F, 2008, PROCEEDINGS OF THE EYE TRACKING RESEARCH AND APPLICATIONS SYMPOSIUM (ETRA 2008), P111, DOI 10.1145/1344471.1344500
Stjerna S, 2012, JOVE-J VIS EXP, DOI 10.3791/3774
Thayyil S, 2010, PEDIATRICS, V125, P382
Wass S, 2011, CURR BIOL, V21, P1543, DOI 10.1016/j.cub.2011.08.004
Wass SV, 2013, BEHAV RES METHODS, V45, P229, DOI 10.3758/s13428-012-0245-6
NR 45
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 20
PY 2014
VL 9
IS 5
AR e97299
DI 10.1371/journal.pone.0097299
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM0UW
UT WOS:000339563400019
PM 24845102
ER
PT J
AU Gustafsson, P
Kerekes, N
Anckarsater, H
Lichtenstein, P
Gillberg, C
Rastam, M
AF Gustafsson, Peik
Kerekes, Nora
Anckarsater, Henrik
Lichtenstein, Paul
Gillberg, Christopher
Rastam, Maria
TI Motor function and perception in children with neuropsychiatric and
conduct problems: results from a population based twin study
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Conduct Disorder; Attention-Deficit/Hyperactivity Disorder; Autism
Spectrum Disorder; Motor control; Perception; A-TAC
ID DEFICIT-HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; NEUROLOGICAL SOFT-SIGNS; ASPERGER-SYNDROME; A-TAC; 7-YEAR-OLD
CHILDREN; ANTISOCIAL-BEHAVIOR; NEUROMOTOR DEFICITS; TELEPHONE INTERVIEW;
6-YEAR-OLD CHILDREN
AB Background: Children with early symptomatic psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) have been found to have high rates of motor and/or perception difficulties. However, there have been few large-scale studies reporting on the association between Conduct Disorder (CD) and motor/perception functions. The aim of the present study was to investigate how motor function and perception relate to measures of ADHD, ASD, and CD.
Methods: Parents of 16,994 Swedish twins (ages nine and twelve years) were interviewed using the Autism-Tics, ADHD and other Comorbidities inventory (A-TAC), which has been validated as a screening instrument for early onset child psychiatric disorders and symptoms. Associations between categorical variables of scoring above previously validated cut-off values for diagnosing ADHD, ASD, and CD on the one hand and motor and/or perception problems on the other hand were analysed using cross-tabulations, and the Fisher exact test. Associations between the continuous scores for ADHD, ASD, CD, and the subdomains Concentration/Attention, Impulsiveness/Activity, Flexibility, Social Interaction and Language, and the categorical factors age and gender, on the one hand, and the dependent dichotomic variables Motor control and Perception problems, on the other hand, were analysed using binary logistic regression in general estimated equation models.
Results: Male gender was associated with increased risk of Motor control and/or Perception problems. Children scoring above the cut-off for ADHD, ASD, and/or CD, but not those who were `CD positive' but `ADHD/ASD negative', hadmore Motor control and/or Perception problems, compared with children who were screen-negative for all three diagnoses. In the multivariable model, CD and Impulsiveness/Activity had no positive associations with Motor control and/or Perception problems.
Conclusions: CD symptoms or problems with Impulsiveness/Activity were associated with Motor control or Perception problems only in the presence of ASD symptoms and/or symptoms of inattention. Our results indicate that children with CD but without ASD or inattention do not show a deviant development of motor and perceptual functions. Therefore, all children with CD should be examined concerning motor control and perception. If problems are present, a suspicion of ADHD and/or ASD should be raised.
C1 [Gustafsson, Peik; Rastam, Maria] Lund Univ, Dept Clin Sci, SE-22240 Lund, Sweden.
[Kerekes, Nora; Anckarsater, Henrik] Univ Gothenburg, CELAM Ctr Eth Law & Mental Hlth, Gothenburg, Sweden.
[Kerekes, Nora] Swedish Prison & Probat Serv, R&D Gothenburg, Gothenburg, Sweden.
[Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
RP Gustafsson, P (reprint author), Lund Univ, Dept Clin Sci, Baravagen 1C, SE-22240 Lund, Sweden.
EM peik.gustafsson@med.lu.se
RI Kerekes, Nora/C-6474-2009
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Anckarsater H, 2008, OPEN PSYCHIAT J, V2, P5, DOI DOI 10.2174/1874354400802010005
Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
Caspi A, 2004, DEV PSYCHOL, V40, P149, DOI 10.1037/0012-1649.40.20.149
Connors Lenke M, 2003, NEWBORN INF NUTS REV, V3, P104, DOI 10.1016/S1527-3369(03)00032-1
Cubo E, 2011, AN PEDIATR, V75, P40, DOI 10.1016/j.anpedi.2011.01.008
Evans D. M., 2000, GENESCREEN, V1, P77, DOI 10.1046/j.1466-9218.2000.00027.x
Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
Freitag CM, 2007, J AUTISM DEV DISORD, V37, P948, DOI 10.1007/s10803-006-0235-6
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
GHAZIUDDIN M, 1994, J INTELL DISABIL RES, V38, P519
Gillberg Christopher, 2003, Neural Plasticity, V10, P59, DOI 10.1155/NP.2003.59
Gillberg C, 2003, ARCH DIS CHILD, V88, P904, DOI 10.1136/adc.88.10.904
GILLBERG C, 1982, J CHILD PSYCHOL PSYC, V23, P131, DOI 10.1111/j.1469-7610.1982.tb00058.x
Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
GILLBERG IC, 1988, ACTA PAEDIATR SCAND, V77, P450
Gustafsson P, 2000, ACTA PAEDIATR, V89, P830, DOI 10.1080/080352500750043747
Gustafsson P, 2010, DEV MED CHILD NEUROL, V52, P364, DOI 10.1111/j.1469-8749.2009.03407.x
Hansson SL, 2005, BRIT J PSYCHIAT, V187, P262, DOI 10.1192/bjp.187.3.262
HARTSOUGH CS, 1985, AM J ORTHOPSYCHIAT, V55, P190
Jeste SS, 2011, CURR OPIN NEUROL, V24, P132, DOI 10.1097/WCO.0b013e3283446450
Kadesjo B, 1999, J AM ACAD CHILD PSY, V38, P820, DOI 10.1097/00004583-199907000-00011
KNOBLOCH H, 1956, JAMA-J AM MED ASSOC, V161, P581
Lambek R, 2010, J CHILD PSYCHOL PSYC, V51, P895, DOI 10.1111/j.1469-7610.2010.02248.x
Landgren M, 1996, DEV MED CHILD NEUROL, V38, P891
Larson T, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-1
Levy F, 2005, J AM ACAD CHILD PSY, V44, P368, DOI 10.1097/01.chi.0000153232.64968.cl
Loeber R, 1986, CRIME JUSTICE ANN RE, V7, P219
MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
Martin NC, 2006, INT J DISABIL DEV ED, V53, P21, DOI DOI 10.1080/10349120500509992
MOFFITT TE, 1988, J ABNORM CHILD PSYCH, V16, P553, DOI 10.1007/BF00914266
Moruzzi S, 2011, J AUTISM DEV DISORD, V41, P1665, DOI 10.1007/s10803-011-1199-8
Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
Nigg JT, 1998, J ABNORM PSYCHOL, V107, P468, DOI 10.1037/0021-843X.107.3.468
Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
Raine A, 2005, J ABNORM PSYCHOL, V114, P38, DOI 10.1037/0021-843X.114.1.38
Raine A, 1996, ARCH GEN PSYCHIAT, V53, P544
Raine A, 2002, DEV PSYCHOPATHOL, V14, P25, DOI 10.1017/S0954579402001025
RASMUSSEN P, 1983, DEV MED CHILD NEUROL, V25, P315
Rhee SH, 2002, PSYCHOL BULL, V128, P490, DOI 10.1037//0033-2909.128.3.490
Robinson EB, 2012, BEHAV GENET, V42, P245, DOI 10.1007/s10519-011-9500-3
Rogers Tiffany D, 2013, Front Syst Neurosci, V7, P15, DOI 10.3389/fnsys.2013.00015
Spencer TJ, 2007, AMBUL PEDIATR, V7, P73, DOI 10.1016/j.ambp.2006.07.006
Stanger C, 2004, J CLIN CHILD ADOLESC, V33, P590, DOI 10.1207/s15374424jccp3303_16
Strauss AA, 1947, PSYCHOPATHOLOGY ED B
Whyatt C, 2013, FRONT INTEGR NEUROSC, V7, P1, DOI DOI 10.3389/FNINT.2013.00051
NR 47
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD MAY 20
PY 2014
VL 6
AR 11
DI 10.1186/1866-1955-6-11
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AK5MG
UT WOS:000338468100001
PM 24872861
ER
PT J
AU Engineer, CT
Centanni, TM
Im, KW
Rahebi, KC
Buell, EP
Kilgard, MP
AF Engineer, Crystal T.
Centanni, Tracy M.
Im, Kula W.
Rahebi, Kimiya C.
Buell, Elizabeth P.
Kilgard, Michael P.
TI Degraded speech sound processing in a rat model of fragile X syndrome
SO BRAIN RESEARCH
LA English
DT Article
DE Fragile X syndrome; Speech; Auditory cortex
ID CORTICAL ACTIVITY PATTERNS; AUTISM SPECTRUM DISORDERS; PRIMARY
AUDITORY-CORTEX; MENTAL-RETARDATION PROTEIN; CRITICAL PERIOD PLASTICITY;
WORKING-MEMORY; MOUSE MODEL; DISCRIMINATION ABILITY; INSULAR CORTEX;
ENVIRONMENTAL ENRICHMENT
AB Fragile X syndrome is the most common inherited form of intellectual disability and the leading genetic cause of autism. Impaired phonological processing in fragile X syndrome interferes with the development of language skills. Although auditory cortex responses are known to be abnormal in fragile X syndrome, it is not clear how these differences impact speech sound processing. This study provides the first evidence that the cortical representation of speech sounds is impaired in Fmr1 knockout rats, despite normal speech discrimination behavior. Evoked potentials and spiking activity in response to speech sounds, noise burst trains, and tones were significantly degraded in primary auditory cortex, anterior auditory field and the ventral auditory field. Neurometric analysis of speech evoked activity using a pattern classifier confirmed that activity in these fields contains significantly less information about speech sound identity in Fmr1 knockout rats compared to control rats. Responses were normal in the posterior auditory field, which is associated with sound localization. The greatest impairment was observed in the ventral auditory field, which is related to emotional regulation. Dysfunction in the ventral auditory field may contribute to poor emotional regulation in fragile X syndrome and may help explain the observation that later auditory evoked responses are more disturbed in fragile X syndrome compared to earlier responses. Rodent models of fragile X syndrome are likely to prove useful for understanding the biological basis of fragile X syndrome and for testing candidate therapies. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Engineer, Crystal T.; Centanni, Tracy M.; Im, Kula W.; Rahebi, Kimiya C.; Buell, Elizabeth P.; Kilgard, Michael P.] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75080 USA.
RP Engineer, CT (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci, 800 West Campbell Rd GR41, Richardson, TX 75080 USA.
EM novitski@utdallas.edu
FU National Institutes of Health [5R01DC010433]
FX The authors would like to thank Akbar Afsar, Stephanie Barata, Laura
Baxter, Ian Heimbuch, Ashley Ramdeen, Ryan Russell, Amreen Sitabkhan,
Jacob VanNattan, and Nujeen Zubari for running behavior training
sessions. This work was supported by a grant from the National
Institutes of Health (Grant # 5R01DC010433 to M.P.K.).
CR Ahveninen J, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3585
Amott S.R., 2005, J COGNITIVE NEUROSCI, V17, P819
Anderson JS, 2010, AM J NEURORADIOL, V31, P131, DOI 10.3174/ajnr.A1789
Arriaga G, 2013, BRAIN LANG, V124, P96, DOI 10.1016/j.bandl.2012.10.002
Bagni C, 2013, AM J MED GENET A, V161, P2809, DOI 10.1002/ajmg.a.36241
Baker S, 2011, J INTELL DISABIL RES, V55, P19, DOI 10.1111/j.1365-2788.2010.01343.x
Barnes E, 2009, J SPEECH LANG HEAR R, V52, P1048, DOI 10.1044/1092-4388(2009/08-0001)
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Boddaert N, 2004, AM J PSYCHIAT, V161, P2117, DOI 10.1176/appi.ajp.161.11.2117
Bomba MD, 2004, INT J PSYCHOPHYSIOL, V53, P161, DOI 10.1016/j.ijpsycho.2004.04.001
Bostrom CA, 2013, CEREB CORTEX
Castren M, 2003, BRAIN TOPOGR, V15, P165, DOI 10.1023/A:1022606200636
Centanni TM, 2013, CEREB CORTEX
Centanni TM, 2014, NEUROSCIENCE, V258, P292, DOI 10.1016/j.neuroscience.2013.11.030
Centanni TM, 2013, J NEUROPHYSIOL, V110, P177, DOI 10.1152/jn.00092.2013
Chang EF, 2010, NAT NEUROSCI, V13, P1428, DOI 10.1038/nn.2641
Dansie LE, 2013, NEUROSCIENCE, V246, P186, DOI 10.1016/j.neuroscience.2013.04.058
D'Antuono M, 2003, NEUROSCIENCE, V119, P9, DOI 10.1016/S0306-4522(03)00103-9
DeWitt I, 2012, P NATL ACAD SCI USA, V109, pE505, DOI 10.1073/pnas.1113427109
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Doupe AJ, 1999, ANNU REV NEUROSCI, V22, P567, DOI 10.1146/annurev.neuro.22.1.567
Engineer CT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078607
Engineer C.T., 2014, DEV NEUROBIOL
Engineer CT, 2008, NAT NEUROSCI, V11, P603, DOI 10.1038/nn.2109
Engineer CT, 2014, BEHAV BRAIN RES, V258, P166, DOI 10.1016/j.bbr.2013.10.021
Engineer ND, 2012, NEUROSCIENCE, V205, P81, DOI 10.1016/j.neuroscience.2011.12.056
Frank MG, 2001, NEURON, V30, P275, DOI 10.1016/S0896-6273(01)00279-3
Frankland PW, 2004, MOL PSYCHIATR, V9, P417, DOI 10.1038/sj.mp.4001432
Goncalves JT, 2013, NAT NEUROSCI, V16, P903, DOI 10.1038/nn.3415
Gothelf D, 2008, ANN NEUROL, V63, P40, DOI 10.1002/ana.21243
Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
Hall SS, 2013, JAMA PSYCHIAT, V70, P1215, DOI 10.1001/jamapsychiatry.2013.247
Harlow EG, 2010, NEURON, V65, P385, DOI 10.1016/j.neuron.2010.01.024
Hays SA, 2011, J NEUROSCI, V31, P14223, DOI 10.1523/JNEUROSCI.3157-11.2011
He Q, 2014, J NEUROSCI, V34, P446, DOI 10.1523/JNEUROSCI.4447-13.2014
Hessl D, 2002, PSYCHONEUROENDOCRINO, V27, P855, DOI 10.1016/S0306-4530(01)00087-7
Hinton R, 2013, DEV NEUROREHABIL, V16, P58, DOI 10.3109/17518423.2012.704414
Jakkamsetti V, 2012, J NEUROPHYSIOL, V107, P1457, DOI 10.1152/jn.01057.2010
Johnson-Glenberg MC, 2008, COGN SYST RES, V9, P274, DOI 10.1016/j.cogsys.2008.02.002
Kawahara H, 1997, INT CONF ACOUST SPEE, P1303, DOI 10.1109/ICASSP.1997.596185
Keenan JM, 2004, COGN NEUROPSYCHOL, V21, P579, DOI 10.1080/02643290342000294
Kilgard MP, 1999, HEARING RES, V134, P16, DOI 10.1016/S0378-5955(99)00061-1
Kim H, 2013, J NEUROSCI, V33, P15686, DOI 10.1523/JNEUROSCI.3246-12.2013
Kimura A, 2010, NEUROSCIENCE, V166, P1140, DOI 10.1016/j.neuroscience.2010.01.032
Kimura A, 2007, EUR J NEUROSCI, V25, P2819, DOI 10.1111/j.1460-9568.2007.05519.x
Knoth I.S., 2012, FRONT HUM NEUROSCI, V6
Kudoh M, 2006, NEUROREPORT, V17, P1761, DOI 10.1097/WNR.0b013e32800fef9d
Lai G, 2011, RADIOLOGY, V260, P521, DOI 10.1148/radiol.11101576
LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
Lomber SG, 2008, NAT NEUROSCI, V11, P609, DOI 10.1038/nn.2108
Meredith RM, 2007, NEURON, V54, P627, DOI 10.1016/j.neuron.2007.04.028
Michalon A, 2014, BIOL PSYCHIAT, V75, P189, DOI 10.1016/j.biopsych.2013.05.038
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Miller LJ, 1999, AM J MED GENET, V83, P268, DOI 10.1002/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.3.CO;2-B
Murphy MM, 2003, INT REV RES MENT RET, V27, P83
Olmos-Serrano JL, 2011, DEV NEUROSCI-BASEL, V33, P395, DOI 10.1159/000332884
Osterweil EK, 2010, J NEUROSCI, V30, P15616, DOI 10.1523/JNEUROSCI.3888-10.2010
Ouimet T, 2012, ANN NY ACAD SCI, V1252, P325, DOI 10.1111/j.1749-6632.2012.06453.x
Padmashri R, 2013, J NEUROSCI, V33, P19715, DOI 10.1523/JNEUROSCI.2514-13.2013
Percaccio CR, 2005, J NEUROPHYSIOL, V94, P3590, DOI 10.1152/jn.00433.2005
Percaccio CR, 2007, BRAIN RES, V1174, P76, DOI 10.1016/j.brainres.2007.07.062
Perez CA, 2013, CEREB CORTEX, V23, P670, DOI 10.1093/cercor/bhs045
Petkov Christopher I, 2012, Front Evol Neurosci, V4, P12, DOI 10.3389/fnevo.2012.00012
Pierpont EI, 2011, J NEURODEV DISORD, V3, P335, DOI 10.1007/s11689-011-9095-2
Polley DB, 2007, J NEUROPHYSIOL, V97, P3621, DOI 10.1152/jn.01298.2006
Porter BA, 2011, BEHAV BRAIN RES, V219, P68, DOI 10.1016/j.bbr.2010.12.015
Puckett AC, 2007, J NEUROPHYSIOL, V98, P253, DOI 10.1152/jn.01309.2006
Rama P, 2004, CEREB CORTEX, V14, P768, DOI 10.1093/cercor/bhh037
Ranasinghe KG, 2013, NEUROSCIENCE, V252, P80, DOI 10.1016/j.neuroscience.2013.08.005
Ranasinghe KG, 2012, JARO-J ASSOC RES OTO, V13, P527, DOI 10.1007/s10162-012-0328-1
Reed A, 2011, NEURON, V70, P121, DOI 10.1016/j.neuron.2011.02.038
REISS AL, 1994, NEUROLOGY, V44, P1317
Remedios R, 2009, J NEUROSCI, V29, P1034, DOI 10.1523/JNEUROSCI.4089-08.2009
Rinaldi T, 2008, FRONT NEURAL CIRCUIT, V2, DOI 10.3389/neuro.04.004.2008
Roberts J, 2005, J SPEECH LANG HEAR R, V48, P494, DOI 10.1044/1092-4388(2005/034)
Roberts JE, 2013, J PEDIATR PSYCHOL, V38, P276, DOI 10.1093/jpepsy/jss114
Rodgers KM, 2008, CEREB CORTEX, V18, P2941, DOI 10.1093/cercor/bhn054
Rojas DC, 2001, NEUROREPORT, V12, P2573, DOI 10.1097/00001756-200108080-00056
Rotschafer S, 2013, BRAIN RES, V1506, P12, DOI 10.1016/j.brainres.2013.02.038
Russo N, 2009, J AUTISM DEV DISORD, V39, P1185, DOI 10.1007/s10803-009-0737-0
SAKURAI Y, 1994, J NEUROSCI, V14, P2606
Shetake JA, 2011, EUR J NEUROSCI, V34, P1823, DOI 10.1111/j.1460-9568.2011.07887.x
Smith PH, 2012, J COMP NEUROL, V520, P34, DOI 10.1002/cne.22682
STCLAIR DM, 1987, BIOL PSYCHIAT, V22, P303, DOI 10.1016/0006-3223(87)90148-X
Storace DA, 2010, J COMP NEUROL, V518, P1630, DOI 10.1002/cne.22345
Strumbos JG, 2010, J NEUROSCI, V30, P10263, DOI 10.1523/JNEUROSCI.1125-10.2010
SUDHALTER V, 1991, AM J MED GENET, V38, P493, DOI 10.1002/ajmg.1320380270
Van der Molen MJW, 2012, CLIN NEUROPHYSIOL, V123, P1309, DOI 10.1016/j.clinph.2011.11.039
Van der Molen MJW, 2012, CLIN NEUROPHYSIOL, V123, P720, DOI 10.1016/j.clinph.2011.08.023
Wang H, 2008, NEURON, V59, P634, DOI 10.1016/j.neuron.2008.06.027
NR 90
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD MAY 20
PY 2014
VL 1564
BP 72
EP 84
DI 10.1016/j.brainres.2014.03.049
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA AI2QU
UT WOS:000336703900008
PM 24713347
ER
PT J
AU Tan, ES
Yong, MH
Lim, ECP
Li, ZH
Brett, MSY
Tan, EC
AF Tan, Ee-Shien
Yong, Min-Hwee
Lim, Eileen C. P.
Li, Zhi-hui
Brett, Maggie S. Y.
Tan, Ene-Choo
TI Chromosome 15q11-q13 copy number gain detected by array-CGH in two cases
with a maternal methylation pattern
SO MOLECULAR CYTOGENETICS
LA English
DT Article
DE 15q duplication syndrome; Array comparative genomic hybridization
(aCGH); Copy number gain; Autism; Developmental delay; Fluorescence in
situ hybridization (FISH); Marker chromosome
ID AUTISM-SPECTRUM DISORDERS; PRADER-WILLI-SYNDROME; INTERSTITIAL
DUPLICATION; HIGH-RESOLUTION; SCHIZOPHRENIA; REGION; REARRANGEMENTS;
ABNORMALITIES; PHENOTYPE; 15Q
AB Background: The 15q11-q13 region contains many low copy repeats and is well known for its genomic instability. Several syndromes are associated with genomic imbalance or copy-number-neutral uniparental disomy. We report on two patients: Patient 1 is a boy with developmental delay and autism; and Patient 2 is a girl with developmental delay, hypotonia and dysmorphism. We performed analyses to delineate their dosage in the 15q region, determine whether the patients' dosage correlates with phenotypic severity, and whether genes in the amplified regions are significantly associated with identified functional networks.
Results: For the proximal region of 15q, molecular cytogenetic analysis with Agilent oligonucleotide array showed a copy number of 3 for Patient 1 and a copy number of 4 for Patient 2. Fluorescent in situ hybridization analysis of Patient 2 showed two different populations of cells with different marker chromosomes. Methylation analysis of the amplified region showed that the extra copies of small nuclear ribonucleoprotein polypeptide N gene were of maternal origin. Phenotypic severity did not correlate with the size and dosage of 15q, or whether the amplification is interstitial or in the form of a supernumerary marker. Pathway analysis showed that in Patient 2, the main functional networks that are affected by the genes from the duplicated/triplicated regions are developmental disorder, neurological disease and hereditary disease.
Conclusions: The 15q11-q13 gains that were found in both patients could explain their phenotypic presentations. This report expands the cohort of patients for which 15q11-q13 duplications are molecularly characterized.
C1 [Tan, Ee-Shien] KK Womens & Childrens Hosp, Genet Serv, Singapore 229899, Singapore.
[Yong, Min-Hwee] KK Womens & Childrens Hosp, Cytogenet Lab, Singapore 229899, Singapore.
[Lim, Eileen C. P.; Brett, Maggie S. Y.; Tan, Ene-Choo] KK Womens & Childrens Hosp, KK Res Lab, Singapore 229899, Singapore.
[Li, Zhi-hui] Genomax Technol Pte Ltd, Singapore 117586, Singapore.
[Tan, Ene-Choo] Duke NUS Grad Med Sch, Off Clin Sci, Singapore 169857, Singapore.
RP Tan, EC (reprint author), KK Womens & Childrens Hosp, KK Res Lab, 100 Bukit Timah Rd, Singapore 229899, Singapore.
EM tanec@bigfoot.com
FU Agency for Science and Technology and Research [BMRC 06/1/50/19/485];
National Medical Research Council, Ministry of Health, Republic of
Singapore [NMRC/PPG/KKH12010-Theme3]
FX This work was supported by BMRC 06/1/50/19/485 (Agency for Science and
Technology and Research) and NMRC/PPG/KKH12010-Theme3 (National Medical
Research Council, Ministry of Health, Republic of Singapore). The
authors appreciate the medical editing assistance of Jon Kilner, MS, MA
(Pittsburgh, Pennsylvania, USA).
CR Al Ageeli E, 2014, EUR J MED GENET, V57, P5, DOI 10.1016/j.ejmg.2013.10.008
Bassett AS, 2010, AM J PSYCHIAT, V167, P899, DOI 10.1176/appi.ajp.2009.09071016
Battaglia A, 2008, ORPHANET J RARE DIS, V3, DOI 10.1186/1750-1172-3-30
Battaglia A, 2010, AM J MED GENET C, V154C, P448, DOI 10.1002/ajmg.c.30281
Biesecker LG, 2013, NAT REV GENET, V14, P307, DOI 10.1038/nrg3424
Browne CE, 1997, AM J HUM GENET, V61, P1342, DOI 10.1086/301624
Burnside R, 2011, HUM GENET, V130, P517, DOI 10.1007/s00439-011-0970-4
Cai GQ, 2008, BMC MED GENOMICS, V1, DOI 10.1186/1755-8794-1-50
Cassidy SB, 2012, GENET MED, V14, P10, DOI 10.1038/gim.0b013e31822bead0
Crespi BJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-15
de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
Depienne C, 2009, BIOL PSYCHIAT, V66, P349, DOI 10.1016/j.biopsych.2009.01.025
Galardi S, 2002, MOL CELL BIOL, V22, P6663, DOI 10.1128/MCB.22.19.6663-6668.2002
Hedges DJ, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-2
Hoebeeck J, 2005, LAB INVEST, V85, P24, DOI 10.1038/labinvest.3700209
Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014
Hogart A, 2009, J MED GENET, V46, P86, DOI 10.1136/jmg.2008.061580
Hosak L, 2012, NEUROENDOCRINOL LETT, V33, P183
Kishore S, 2010, HUM MOL GENET, V19, P1153, DOI 10.1093/hmg/ddp585
Kitsiou-Tzeli S, 2010, AM J MED GENET A, V152A, P1925, DOI 10.1002/ajmg.a.33447
Kubota T, 1997, NAT GENET, V16, P16
Matsunami N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0052239
Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
Moreno-De-Luca D, 2013, MOL PSYCHIATR, V18, P1090, DOI 10.1038/mp.2012.138
Orrico A, 2009, AM J MED GENET A, V149A, P1033, DOI 10.1002/ajmg.a.32785
Pujana MA, 2002, EUR J HUM GENET, V10, P26, DOI 10.1038/sj/ejhg/5200760
Runte M, 2005, HUM GENET, V116, P228, DOI 10.1007/s00439-004-1219-2
SAADALLAH N, 1983, J MED GENET, V20, P290, DOI 10.1136/jmg.20.4.290
Sridhar P, 2008, J BIOMED SCI, V15, P697, DOI 10.1007/s11373-008-9271-x
Stewart LR, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-154
Tatton-Brown K, 2009, AM J MED GENET A, V149A, P147, DOI 10.1002/ajmg.a.32534
Urraca N, 2013, AUTISM RES, V6, P268, DOI 10.1002/aur.1284
Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757
Wandstrat AE, 2000, CHROMOSOMA, V109, P498, DOI 10.1007/s004120000103
Wang NJ, 2004, AM J HUM GENET, V75, P267, DOI 10.1086/422854
Yang J, 2013, BMC MED GENET, V14, P9
YUNIS JJ, 1976, SCIENCE, V191, P1268, DOI 10.1126/science.1257746
NR 37
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8166
J9 MOL CYTOGENET
JI Mol. Cytogenet.
PD MAY 16
PY 2014
VL 7
AR 32
DI 10.1186/1755-8166-7-32
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA AK5JM
UT WOS:000338460800001
PM 24959201
ER
PT J
AU Takahashi, M
Ishida, M
Saito, T
Ohshima, T
Hisanaga, S
AF Takahashi, Miyuki
Ishida, Manami
Saito, Taro
Ohshima, Toshio
Hisanaga, Shin-ichi
TI Valproic acid downregulates Cdk5 activity via the transcription of the
p35 mRNA
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Cdk5; Valproic acid; Transcription; p35; Autism; HDAC
ID CYCLIN-DEPENDENT KINASE-5; HISTONE DEACETYLASE; CORTICAL-NEURONS;
ACTIVATOR; PHOSPHORYLATION; DEGRADATION; PLASTICITY; INHIBITION;
PROTEASOME; EXPRESSION
AB The cyclin-dependent kinase 5 (Cdk5) is a neuron-specific Ser/Thr kinase that is activated by the regulatory subunit p35. Overactivation of Cdk5, which is induced by the cleavage of p35 by calpain, is implicated in neuronal death in various neurodegenerative diseases. In contrast, depletion of the Cdk5 activity renders neurons vulnerable to stresses. Recent reports suggest the involvement of Cdk5 in mental disorders. We hypothesized that perturbation of Cdk5 activity is related to mental conditions. To verify this hypothesis, we investigated the effect of valproic acid (VPA), which is a drug of choice for psychiatric disorders, on Cdk5 activity. VPA decreased the expression of p35 at both the protein and mRNA levels in cultured neurons, resulting in a decrease of Cdk5 activity. VPA decreased the p35 mRNA via histone deacetylase inhibition. The chronic administration of VPA also downregulated p35 in mouse brains. These results indicate that VPA regulates Cdk5 activity in neurons via p35 transcription mediated by HDAC inhibition. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Takahashi, Miyuki; Ishida, Manami; Saito, Taro; Hisanaga, Shin-ichi] Tokyo Metropolitan Univ, Dept Biol Sci, Hachioji, Tokyo 1920397, Japan.
[Ohshima, Toshio] Waseda Univ, Dept Life Sci & Med Biosci, Shinjuku Ku, Tokyo 1628480, Japan.
RP Hisanaga, S (reprint author), Tokyo Metropolitan Univ, Dept Biol Sci, Hachioji, Tokyo 1920397, Japan.
EM hisanaga-shinichi@tmu.ac.jp
FU Scientific Research from MEXT of Japan
FX This work was supported in part by Grants-in-Aid for Scientific Research
from MEXT of Japan (S.H.).
CR Bowden CL, 2003, BIPOLAR DISORD, V5, P189, DOI 10.1034/j.1399-5618.2003.00031.x
Cheung Zelda H., 2007, Biotechnology Journal, V2, P949, DOI 10.1002/biot.200700056
Chomiak T, 2013, NEUROTOXICOL TERATOL, V36, P57, DOI 10.1016/j.ntt.2012.08.005
Dhavan R, 2001, NAT REV MOL CELL BIO, V2, P749, DOI 10.1038/35096019
Drerup JM, 2010, BIOL PSYCHIAT, V68, P1163, DOI 10.1016/j.biopsych.2010.07.016
Engmann O, 2011, BRAIN, V134, P2408, DOI 10.1093/brain/awr155
Fukuchi M, 2009, NEUROSCI RES, V65, P35, DOI 10.1016/j.neures.2009.05.002
Gurvich N, 2002, PHARMACOL THERAPEUT, V96, P45, DOI 10.1016/S0163-7258(02)00299-1
Harada T, 2001, NAT CELL BIOL, V3, P453, DOI 10.1038/35074516
Hawasli AH, 2007, NAT NEUROSCI, V10, P880, DOI 10.1038/nn1914
Hisanaga S, 2010, J NEUROCHEM, V115, P1309, DOI 10.1111/j.1471-4159.2010.07050.x
Hosokawa T, 2006, J NEUROSCI RES, V84, P747, DOI 10.1002/jnr.20975
Hsieh J, 2005, CURR OPIN CELL BIOL, V17, P664, DOI 10.1016/j.ceb.2005.09.002
Hu JP, 2011, BRAIN RES BULL, V85, P194, DOI 10.1016/j.brainresbull.2011.03.006
Johannessen CU, 2000, NEUROCHEM INT, V37, P103, DOI 10.1016/S0197-0186(00)00013-9
Kawauchi T, 2013, GENES CELLS, V18, P176, DOI 10.1111/gtc.12029
Lai KO, 2012, NAT NEUROSCI, V15, P1506, DOI 10.1038/nn.3237
Li BS, 2000, J NEUROSCI, V20, P6055
Marinova Z, 2009, J NEUROCHEM, V111, P976, DOI 10.1111/j.1471-4159.2009.06385.x
Minegishi S, 2010, BIOCHEMISTRY-US, V49, P5482, DOI 10.1021/bi100631f
Newton SS, 2006, MOL PHARMACOL, V70, P440, DOI 10.1124/mol.106.027078
Ohshima T, 1996, GENOMICS, V35, P372, DOI 10.1006/geno.1996.0370
Ohshima T, 1996, P NATL ACAD SCI USA, V93, P11173, DOI 10.1073/pnas.93.20.11173
Patrick GN, 1998, J BIOL CHEM, V273, P24057, DOI 10.1074/jbc.273.37.24057
Phiel CJ, 2001, J BIOL CHEM, V276, P36734, DOI 10.1074/jbc.M101287200
Plattner F, 2014, NEURON, V81, P1070, DOI 10.1016/j.neuron.2014.01.022
Rogawski MA, 2004, NAT MED, V10, P685, DOI 10.1038/nm1074
Saito T, 1998, BIOCHEM BIOPH RES CO, V252, P775, DOI 10.1006/bbrc.1998.9739
Saito T, 2003, J NEUROSCI, V23, P1189
Sananbenesi F, 2007, NAT NEUROSCI, V10, P1012, DOI 10.1038/nn1943
Tang XX, 2004, CLIN CANCER RES, V10, P5837, DOI 10.1158/1078-0432.CCR-04-0395
Utreras E, 2009, J BIOL CHEM, V284, P2275, DOI 10.1074/jbc.M805052200
Wei FY, 2005, J NEUROCHEM, V93, P502, DOI 10.1111/j.1471-4159.2005.03058.x
Yamada M, 2007, J NEUROCHEM, V102, P1477, DOI 10.1111/j.1471-4159.2007.04505.x
Yger M, 2011, FRONT BEHAV NEUROSCI, V5, DOI 10.3389/fnbeh.2011.00056
NR 35
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAY 16
PY 2014
VL 447
IS 4
BP 678
EP 682
DI 10.1016/j.bbrc.2014.04.072
PG 5
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AI0RM
UT WOS:000336557300022
PM 24755075
ER
PT J
AU Dere, E
Dahm, L
Lu, D
Hammerschmidt, K
Ju, A
Tantra, M
Kastner, A
Chowdhury, K
Ehrenreich, H
AF Dere, Ekrem
Dahm, Liane
Lu, Derek
Hammerschmidt, Kurt
Ju, Anes
Tantra, Martesa
Kaestner, Anne
Chowdhury, Kamal
Ehrenreich, Hannelore
TI Heterozygous Ambra1 deficiency in mice: a genetic trait with autism-like
behavior restricted to the female gender
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE Ambra1; autophagy; heterozygous null mutant mice; autism composite
score; social interaction; ultrasound communication; repetitive
behavior; cognitive rigidity
ID SPECTRUM DISORDERS; AUTOPHAGY; SCHIZOPHRENIA; SYSTEM; BRAIN; MODEL; RATS
AB Autism-spectrum disorders (ASD) are heterogeneous, highly heritable neurodevelopmental conditions affecting around 0.5% of the population across cultures, with a male/female ratio of approximately 4:1. Phenotypically, ASD are characterized by social interaction and communication deficits, restricted interests, repetitive behaviors, and reduced cognitive flexibility. Identified causes converge at the level of the synapse, ranging from mutation of synaptic genes to quantitative alterations in synaptic protein expression, e.g., through compromised transcriptional or translational control. We wondered whether reduced turnover and degradation of synapses, due to deregulated autophagy, would lead to similar pheno-typical consequences. Ambra1, strongly expressed in cortex, hippocampus, and striatum, is a positive regulator of Beclin1, a principal player in autophagosome formation. While homozygosity of the Ambra1 null mutation causes embryonic lethality, heterozygous mice with reduced Ambra1 expression are viable, reproduce normally, and lack any immediately obvious phenotype. Surprisingly, comprehensive behavioral characterization of these mice revealed an autism-like phenotype in Ambra1(+/-) females only, including compromised communication and social interactions, a tendency of enhanced stereotypies/repetitive behaviors, and impaired cognitive flexibility. Reduced ultrasound communication was found in adults as well as pups, which achieved otherwise normal neurodevelopmental milestones. These features were all absent in male Ambra1(+/-) mice. As a first hint explaining this gender difference, we found a much stronger reduction of Ambra1 protein in the cortex of Ambra1(+/-) females compared to males. To conclude, Ambra1 deficiency can induce an autism-like phenotype. The restriction to the female gender of autism-generation by a defined genetic trait is unique thus far and warrants further investigation.
C1 [Dere, Ekrem; Dahm, Liane; Lu, Derek; Ju, Anes; Tantra, Martesa; Kaestner, Anne; Ehrenreich, Hannelore] Max Planck Inst Expt Med, D-37075 Gottingen, Germany.
[Dere, Ekrem; Ehrenreich, Hannelore] DFG Ctr Nanoscale Microscopy & Mol Physiol Brain, Gottingen, Germany.
[Hammerschmidt, Kurt] German Primate Ctr, Gottingen, Germany.
[Chowdhury, Kamal] Max Planck Inst Biophys Chem, Dept Mol Cell Biol, Gottingen, Germany.
RP Ehrenreich, H (reprint author), Max Planck Inst Expt Med, Hermann Rein St 3, D-37075 Gottingen, Germany.
EM ehrenreich@em.mpg.de
FU Max Planck Society; Max Planck Forderstiftung; DFG (CNMPB); EU-AIMS;
Innovative Medicines Initiative [115300]
FX This work was supported by the Max Planck Society, the Max Planck
Forderstiftung, the DFG (CNMPB) as well as by EU-AIMS. The research of
EU-AIMS receives support from the Innovative Medicines Initiative Joint
Undertaking under grant agreement no. 115300, resources of which are
composed of financial contribution from the European Union's Seventh
Framework Program (FP7/2007-2013), from the EFPIA companies, and from
Autism Speaks.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Beacher FDCC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038355
Bodda C, 2013, AM J PATHOL, V183, P195, DOI 10.1016/j.ajpath.2013.03.019
Bolte S, 2011, AUTISM, V15, P497, DOI 10.1177/1362361310391116
Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
Eack SM, 2013, SCHIZOPHR RES, V148, P24, DOI 10.1016/j.schres.2013.05.013
El-Kordi A, 2013, BEHAV BRAIN RES, V251, P41, DOI 10.1016/j.bbr.2012.11.016
Fimia GM, 2007, NATURE, V447, P1121, DOI 10.1038/nature05925
Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
Hammerschmidt K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041133
Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8
Heyser CJ, 2004, CURR PROTOC NEUROSCI, pChapter 8, DOI [10.1002/0471142301.ns0818s25, DOI 10.1002/0471142301.NS0818S25]
Hill J., 2008, NEUROPEPTIDE TECHNIQ, P131
Huguet G, 2013, ANNU REV GENOM HUM G, V14, P191, DOI 10.1146/annurev-genom-091212-153431
Kanner L, 1943, NERV CHILD, V2, P217
Kirkovski M, 2013, J AUTISM DEV DISORD, V43, P2584, DOI 10.1007/s10803-013-1811-1
Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
Laarakker MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031503
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
Radyushkin K, 2010, GENES BRAIN BEHAV, V9, P592, DOI 10.1111/j.1601-183X.2010.00590.x
Rietschel M, 2012, MOL PSYCHIATR, V17, P906, DOI 10.1038/mp.2011.80
Rinehart NJ, 2011, CURR TOP BEHAV NEURO, V8, P209, DOI 10.1007/7854_2010_96
Satoh Y, 2011, J NEUROSCI, V31, P11953, DOI 10.1523/JNEUROSCI.2349-11.2011
Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
Sepe S, 2014, NEUROBIOL AGING, V35, P96, DOI 10.1016/j.neurobiolaging.2013.07.001
Tilot AK, 2014, HUM MOL GENET, V23, P3212, DOI 10.1093/hmg/ddu031
Van de Weerd HA, 2001, BEHAV PROCESS, V53, P11, DOI 10.1016/S0376-6357(00)00135-2
VORHEES CV, 1979, TOXICOL APPL PHARM, V50, P267, DOI 10.1016/0041-008X(79)90152-2
Weis SN, 2014, NEUROSCIENCE, V256, P201, DOI 10.1016/j.neuroscience.2013.10.046
Wirawan E, 2012, CELL RES, V22, P43, DOI 10.1038/cr.2011.152
Zoghbi HY, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a009886
Zwaigenbaum L, 2012, J AUTISM DEV DISORD, V42, P2585, DOI 10.1007/s10803-012-1515-y
NR 35
TC 4
Z9 4
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD MAY 16
PY 2014
VL 8
AR 181
DI 10.3389/fnbeh.2014.00181
PG 19
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AH2MW
UT WOS:000335956600002
PM 24904333
ER
PT J
AU Jones, MA
Amr, S
Ferebee, A
Huynh, P
Rosenfeld, JA
Miles, MF
Davies, AG
Korey, CA
Warrick, JM
Shiang, R
Elsea, SH
Girirajan, S
Grotewiel, M
AF Jones, Melanie A.
Amr, Sami
Ferebee, Aerial
Huynh, Phung
Rosenfeld, Jill A.
Miles, Michael F.
Davies, Andrew G.
Korey, Christopher A.
Warrick, John M.
Shiang, Rita
Elsea, Sarah H.
Girirajan, Santhosh
Grotewiel, Mike
TI Genetic studies in Drosophila and humans support a model for the
concerted function of CISD2, PPT1 and CLN3 in disease
SO BIOLOGY OPEN
LA English
DT Article
DE RNA interference; Neurodegeneration; Genetic modifiers; Wolfram
syndrome; Copy number variants; Lysosomal storage disease; Gene network
ID DE-NOVO MUTATIONS; NEURONAL CEROID-LIPOFUSCINOSIS; AUTISM SPECTRUM
DISORDERS; COPY NUMBER VARIATION; INTELLECTUAL DISABILITY; MICRODELETION
SYNDROME; ENDOPLASMIC-RETICULUM; DEVELOPMENTAL DELAY; NETWORK
INTEGRATION; DIABETES-MELLITUS
AB Wolframsyndrome (WFS) is a progressive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 and WFS2 are caused by recessive mutations in the genes Wolfram Syndrome 1 (WFS1) and CDGSH iron sulfur domain 2 (CISD2), respectively. To explore the function of CISD2, we performed genetic studies in flies with altered expression of its Drosophila orthologue, cisd2. Surprisingly, flies with strong ubiquitous RNAi-mediated knockdown of cisd2 had no obvious signs of altered life span, stress resistance, locomotor behavior or several other phenotypes. We subsequently found in a targeted genetic screen, however, that altered function of cisd2 modified the effects of overexpressing the fly orthologues of two lysosomal storage disease genes, palmitoyl-protein thioesterase 1 (PPT1 in humans, Ppt1 in flies) and ceroid-lipofuscinosis, neuronal 3 (CLN3 in humans, cln3 in flies), on eye morphology in flies. We also found that cln3 modified the effects of overexpressing Ppt1 in the eye and that overexpression of cln3 interacted with a loss of function mutation in cisd2 to disrupt locomotor ability in flies. Follow-up multi-species bioinformatic analyses suggested that a gene network centered on CISD2, PPT1 and CLN3 might impact disease through altered carbohydrate metabolism, protein folding and endopeptidase activity. Human genetic studies indicated that copy number variants (duplications and deletions) including CLN3, and possibly another gene in the CISD2/PPT1/CLN3 network, are over-represented in individuals with developmental delay. Our studies indicate that cisd2, Ppt1 and cln3 function in concert in flies, suggesting that CISD2, PPT1 and CLN3 might also function coordinately in humans. Further, our studies raise the possibility that WFS2 and some lysosomal storage disorders might be influenced by common mechanisms and that the underlying genes might have previously unappreciated effects on developmental delay.
C1 [Jones, Melanie A.; Amr, Sami; Ferebee, Aerial; Huynh, Phung; Shiang, Rita; Grotewiel, Mike] Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA 23298 USA.
[Amr, Sami; Grotewiel, Mike] Virginia Commonwealth Univ, Mol Biol & Genet Program, Richmond, VA 23298 USA.
[Rosenfeld, Jill A.] Signature Genom Labs, Spokane, WA 99207 USA.
[Miles, Michael F.; Davies, Andrew G.] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA.
[Korey, Christopher A.] Coll Charleston, Dept Biol, Charleston, SC 29401 USA.
[Warrick, John M.] Univ Richmond, Dept Biol, Richmond, VA 23173 USA.
[Elsea, Sarah H.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Girirajan, Santhosh] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA.
[Girirajan, Santhosh] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.
RP Grotewiel, M (reprint author), Virginia Commonwealth Univ, Dept Human & Mol Genet, Med Coll Virginia Campus, Richmond, VA 23298 USA.
EM msgrotewiel@vcu.edu
FU A. D. Williams Foundation (Virginia Commonwealth University); National
Institutes of Health/National Institute on Aging [AG030376]
FX This work was supported by research grants from the A. D. Williams
Foundation (Virginia Commonwealth University) and the National
Institutes of Health/National Institute on Aging [AG030376] to M. G.
CR Altschul SF, 1997, NUCLEIC ACIDS RES, V25, P3389, DOI 10.1093/nar/25.17.3389
Amr S, 2007, AM J HUM GENET, V81, P673, DOI 10.1086/520961
Bachmann-Gagescu R, 2010, GENET MED, V12, P641, DOI 10.1097/GIM.0b013e3181ef4286
Ballif BC, 2008, CLIN GENET, V74, P469, DOI 10.1111/j.1399-0004.2008.01094.x
Ballif BC, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-8
BARRETT TG, 1995, LANCET, V346, P1458, DOI 10.1016/S0140-6736(95)92473-6
Bejjani BA, 2005, AM J MED GENET A, V134A, P259, DOI 10.1002/ajmg.a.30621
Bochukova EG, 2010, NATURE, V463, P666, DOI 10.1038/nature08689
BRAND AH, 1993, DEVELOPMENT, V118, P401
Buff H, 2007, GENETICS, V176, P209, DOI 10.1534/genetics.106.067983
Chan HYE, 2002, HUM MOL GENET, V11, P2895, DOI 10.1093/hmg/11.23.2895
Chen YF, 2009, GENE DEV, V23, P1183, DOI 10.1101/gad.1779509
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
DAVIDSON DJ, 1995, NAT GENET, V9, P351, DOI 10.1038/ng0495-351
de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
Dietzl G, 2007, NATURE, V448, P151, DOI 10.1038/nature05954
Duker AL, 2010, EUR J HUM GENET, V18, P1196, DOI 10.1038/ejhg.2010.102
Fergestad Tim, 2006, Genetics, V173, P1357, DOI 10.1534/genetics.106.057463
Fonseca SG, 2005, J BIOL CHEM, V280, P39609, DOI 10.1074/jbc.M507426200
Freeman M, 1996, CELL, V87, P651, DOI 10.1016/S0092-8674(00)81385-9
Fuss B, 2006, NATURE, V444, P945, DOI 10.1038/nature05412
Gargano JW, 2005, EXP GERONTOL, V40, P386, DOI 10.1016/j.exger.2005.02.005
Girirajan S, 2011, ANNU REV GENET, V45, P203, DOI 10.1146/annurev-genet-102209-163544
Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
Hickey AJ, 2006, GENETICS, V172, P2379, DOI 10.1534/genetics.105.053306
Huang W., 2009, NAT PROTOC, V4, P44, DOI DOI 10.1038/NPR0T.2008.211
Huang W, 2009, NUCLEIC ACIDS RES, V37, P1, DOI DOI 10.1093/NAR/GKN923
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jones MA, 2009, EXP GERONTOL, V44, P532, DOI 10.1016/j.exger.2009.05.007
Korey CA, 2003, BMC NEUROSCI, V4, DOI 10.1186/1471-2202-4-30
Martin I, 2009, FREE RADICAL BIO MED, V47, P803, DOI 10.1016/j.freeradbiomed.2009.06.021
Meyer LR, 2013, NUCLEIC ACIDS RES, V41, pD64, DOI 10.1093/nar/gks1048
Mostafavi S, 2008, GENOME BIOL, V9, DOI 10.1186/gb-2008-9-s1-s4
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Osman AA, 2003, J BIOL CHEM, V278, P52755, DOI 10.1074/jbc.M310331200
Pebrel-Richard C, 2014, EUR J HUM GENET, V22, P369, DOI 10.1038/ejhg.2013.141
Persaud-Sawin DA, 2007, PEDIATR RES, V61, P146, DOI 10.1203/pdr.0b013e31802d8a4a
Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
Reimand J, 2011, NUCLEIC ACIDS RES, V39, pW307, DOI 10.1093/nar/gkr378
Rosenfeld JA, 2010, J NEURODEV DISORD, V2, P26, DOI 10.1007/s11689-009-9037-4
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Scolding NJ, 1996, ANN NEUROL, V39, P352, DOI 10.1002/ana.410390312
Smotrys JE, 2004, ANNU REV BIOCHEM, V73, P559, DOI 10.1146/annurev.biochem.73.011303.073954
Strom TM, 1998, HUM MOL GENET, V7, P2021, DOI 10.1093/hmg/7.13.2021
Tuxworth RI, 2009, HUM MOL GENET, V18, P667, DOI 10.1093/hmg/ddn396
VESA J, 1995, NATURE, V376, P584, DOI 10.1038/376584a0
Walters RG, 2010, NATURE, V463, P671, DOI 10.1038/nature08727
Warde-Farley D, 2010, NUCLEIC ACIDS RES, V38, pW214, DOI 10.1093/nar/gkq537
Warrick JM, 1999, NAT GENET, V23, P425
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Wiley SE, 2007, P NATL ACAD SCI USA, V104, P5318, DOI 10.1073/pnas.0701078104
Wolfram D, 1938, MAYO CLIN P, V9, P715
NR 54
TC 2
Z9 2
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 2046-6390
J9 BIOL OPEN
JI Biol. Open
PD MAY 15
PY 2014
VL 3
IS 5
BP 342
EP 352
DI 10.1242/bio.20147559
PG 11
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AZ2MQ
UT WOS:000348068100005
PM 24705017
ER
PT J
AU Duffy, FH
Shankardass, A
McAnulty, GB
Eksioglu, YZ
Coulter, D
Rotenberg, A
Als, H
AF Duffy, Frank H.
Shankardass, Aditi
McAnulty, Gloria B.
Eksioglu, Yaman Z.
Coulter, David
Rotenberg, Alexander
Als, Heidelise
TI Corticosteroid therapy in regressive autism: a retrospective study of
effects on the Frequency Modulated Auditory Evoked Response (FMAER),
language, and behavior
SO BMC NEUROLOGY
LA English
DT Article
DE Autism; Behavior; Corticosteroids; Distortion; EEG;
Electroencephalogram; Evoked potential; EP; Frequency modulated auditory
evoked response; FMAER; Language; Regression; Spectral; Steroids; STG;
Superior temporal gyrus; Treatment
ID LANDAU-KLEFFNER-SYNDROME; SPECTRUM DISORDERS;
DEVELOPMENTAL-DISABILITIES; EPILEPTIFORM ACTIVITY; INFANTILE SPASMS;
CONTINUOUS SPIKE; CHILDREN; APHASIA; SLEEP; ANOMALIES
AB Background: Up to a third of children with Autism Spectrum Disorder (ASD) manifest regressive autism (R-ASD). They show normal early development followed by loss of language and social skills. Absent evidence-based therapies, anecdotal evidence suggests improvement following use of corticosteroids. This study examined the effects of corticosteroids for R-ASD children upon the 4 Hz frequency modulated evoked response (FMAER) arising from language cortex of the superior temporal gyrus (STG) and upon EEG background activity, language, and behavior. An untreated clinical convenience sample of ASD children served as control sample.
Methods: Twenty steroid-treated R-ASD (STAR) and 24 not-treated ASD patients (NSA), aged 3 - 5 years, were retrospectively identified from a large database. All study participants had two sequential FMAER and EEG studies; Landau-Kleffner syndrome diagnosis was excluded. All subjects' records contained clinical receptive and expressive language ratings based upon a priori developed metrics. The STAR group additionally was scored behaviorally regarding symptom severity as based on the Diagnostic and Statistical Manual IV (DSM-IV) ASD criteria list. EEGs were visually scored for abnormalities. FMAER responses were assessed quantitatively by spectral analysis. Treated and untreated group means and standard deviations for the FMAER, EEG, language, and behavior, were compared by paired t-test and Fisher's exact tests.
Results: The STAR group showed a significant increase in the 4 Hz FMAER spectral response and a significant reduction in response distortion compared to the NSA group. Star group subjects' language ratings were significantly improved and more STAR than NSA group subjects showed significant language improvement. Most STAR group children showed significant behavioral improvement after treatment. STAR group language and behavior improvement was retained one year after treatment. Groups did not differ in terms of minor EEG abnormalities. Steroid treatment produced no lasting morbidity.
Conclusions: Steroid treatment was associated with a significantly increased FMAER response magnitude, reduction of FMAER response distortion, and improvement in language and behavior scores. This was not observed in the non-treated group. These pilot findings warrant a prospective randomized validation trial of steroid treatment for R-ASD utilizing FMAER, EEG, and standardized ASD, language and behavior measures, and a longer follow-up period.
C1 [Duffy, Frank H.; Coulter, David; Rotenberg, Alexander] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA.
[Duffy, Frank H.; Shankardass, Aditi; McAnulty, Gloria B.; Coulter, David; Rotenberg, Alexander; Als, Heidelise] Harvard Univ, Sch Med, Boston, MA 02115 USA.
[Shankardass, Aditi; McAnulty, Gloria B.; Als, Heidelise] Boston Childrens Hosp, Dept Psychiat Psychol, Boston, MA 02115 USA.
[Eksioglu, Yaman Z.] Golisano Childrens Hosp, Syracuse, NY 13292 USA.
[Eksioglu, Yaman Z.] SUNY Upstate Med Univ, Syracuse, NY 13292 USA.
RP Duffy, FH (reprint author), Boston Childrens Hosp, Dept Neurol, 300 Longwood Ave, Boston, MA 02115 USA.
EM fhd@sover.net
FU National Institutes of Health/National Institute of Child Health and
Human Development [R01HD047730]; Harris Foundation; Buehler Family Fund;
Intellectual and Developmental Disabilities Research Center (IDDRC)
[P30HD018655]; Boston Children's Hospital; Tommy Fuss Fund; Harvard
Medical School
FX The authors thank EEG technologists Herman Edwards, R. EEG T. and Sheryl
Manganaro, R. EEG T., for the quality of their data acquisition and for
their consistent efforts over the years. The authors also thank Jack
Connolly, BSIT, R. EEG T., Director of Electroneurodiagnostic Training
Program, for both his supervisory and technical assistance and frequent
more direct support. The professionals acknowledged performed their
roles as part of their regular clinical and research obligations and
were not additionally compensated for their contribution. This work was
supported in part by National Institutes of Health/National Institute of
Child Health and Human Development grant R01HD047730 to Heidelise Als,
PhD, the Harris Foundation (to Dr Als), the Buehler Family Fund (to
DrAls), and the Intellectual and Developmental Disabilities Research
Center (IDDRC) grant P30HD018655 to Scott Pomeroy, MD, PhD, Boston
Children's Hospital and Harvard Medical School. The authors furthermore
acknowledge support from the Tommy Fuss Fund to Joseph
Gonzalez-Heydrich, MD, and thank the Chairmen of Neurology (Dr. Pomeroy)
and Psychiatry (David R. DeMaso, MD) for their continuing support of
these research efforts. The funding bodies indicated above had no role
in study design; in the collection, analysis, and interpretation of
data; in the writing of the manuscript; and in the decision to submit
the manuscript for publication.
CR American Electroencephalographic Society, 1994, J CLIN NEUROPHYSIOL, V11, P111, DOI DOI 10.1097/00004691-199401000-00014
American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th
Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
BARAM TZ, 1993, ANN NEUROL, V33, P231, DOI 10.1002/ana.410330302
Barger BD, 2013, J AUTISM DEV DISORD, V43, P817, DOI 10.1007/s10803-012-1621-x
Chatham WW, 2001, LUPUS, V10, P140, DOI 10.1191/096120301675075008
Chez MG, 2010, NEUROTHERAPEUTICS, V7, P293, DOI 10.1016/j.nurt.2010.05.008
Connolly AM, 1999, J PEDIATR-US, V134, P607, DOI 10.1016/S0022-3476(99)70248-9
DeStefano F, 2013, J PEDIATR-US, V163, P561, DOI 10.1016/j.jpeds.2013.02.001
Dixon WJ, 1985, BMDP STAT SOFTWARE
Duffy FH, 2013, BMC NEUROL, V13, P1
Fernandez IS, 2013, J CHILD NEUROL, V28, P83, DOI 10.1177/0883073812440507
Green GGR, 1979, J PHYSIOL-LONDON, V296, P21
Green G.G.R., 1980, J PHYSL, V307
Holmes GL, 2001, EPILEPSY BEHAV, V2, P272, DOI 10.1006/ebeh.2001.0178
Kovarik J, 2013, PATHOBIOLOGY, V80, P275, DOI 10.1159/000346960
Kurian M, 2011, EPILEPTOLOGIE, V28, P15
LANDAU WM, 1957, NEUROLOGY, V7, P523
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Lesca G, 2012, EPILEPSIA, V53, P1526, DOI 10.1111/j.1528-1167.2012.03559.x
Lewine JD, 1999, PEDIATRICS, V104, P405, DOI 10.1542/peds.104.3.405
Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
Mantovani JF, 2000, DEV MED CHILD NEUROL, V42, P349, DOI 10.1017/S0012162200210621
Martin LA, 2008, BRAIN BEHAV IMMUN, V22, P806, DOI 10.1016/j.bbi.2007.12.007
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
ROGERS SJ, 1990, J AM ACAD CHILD PSY, V29, P863, DOI 10.1097/00004583-199011000-00004
Shenoy S, 2000, J PEDIATR-US, V136, P682, DOI 10.1067/mpd.2000.105355
Sinclair DB, 2005, PEDIATR NEUROL, V32, P300, DOI 10.1016/j.pediatrneurol.2004.12.006
Stafstrom CE, 2011, J CHILD NEUROL, V26, P1411, DOI 10.1177/0883073811413129
STEFANATOS GA, 1995, J AM ACAD CHILD PSY, V34, P1107, DOI 10.1097/00004583-199508000-00022
STEFANATOS GA, 1989, ARCH NEUROL-CHICAGO, V46, P871
Stefanatos GA, 2002, CHILD NEUROPSYCHOL, V8, P195, DOI 10.1076/chin.8.3.195.13498
Stefanatos GA, 2008, NEUROPSYCHOL REV, V18, P305, DOI 10.1007/s11065-008-9073-y
Stefanatos GA, 1997, EVOKED POTENTIAL, V104, P31, DOI 10.1016/S0168-5597(96)96042-6
Stefanatos Gerry A., 2008, Seminars in Speech and Language, V29, P239, DOI 10.1055/s-0028-1082887
Tsuru T, 2000, PEDIATR NEUROL, V22, P145, DOI 10.1016/S0887-8994(99)00127-7
van Drongelen W, 2011, SIGNAL PROCESSING NE, V5
Wu S, 1996, P I PHON SCI AMST, V20, P27
NR 39
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD MAY 15
PY 2014
VL 14
AR 70
DI 10.1186/1471-2377-14-70
PG 17
WC Clinical Neurology
SC Neurosciences & Neurology
GA AH1EQ
UT WOS:000335863000001
PM 24885033
ER
PT J
AU Lionel, AC
Tammimies, K
Vaags, AK
Rosenfeld, JA
Ahn, JW
Merico, D
Noor, A
Runke, CK
Pillalamarri, VK
Carter, MT
Gazzellone, MJ
Thiruvahindrapuram, B
Fagerberg, C
Laulund, LW
Pellecchia, G
Lamoureux, S
Deshpande, C
Clayton-Smith, J
White, AC
Leather, S
Trounce, J
Bedford, HM
Hatchwell, E
Eis, PS
Yuen, RKC
Walker, S
Uddin, M
Geraghty, MT
Nikkel, SM
Tomiak, EM
Fernandez, BA
Soreni, N
Crosbie, J
Arnold, PD
Schachar, RJ
Roberts, W
Paterson, AD
So, J
Szatmari, P
Chrysler, C
Woodbury-Smith, M
Lowry, RB
Zwaigenbaum, L
Mandyam, D
Wei, J
MacDonald, JR
Howe, JL
Nalpathamkalam, T
Wang, ZZ
Tolson, D
Cobb, DS
Wilks, TM
Sorensen, MJ
Bader, PI
An, Y
Wu, BL
Musumeci, SA
Romano, C
Postorivo, D
Nardone, AM
Della Monica, M
Scarano, G
Zoccante, L
Novara, F
Zuffardi, O
Ciccone, R
Antona, V
Carella, M
Zelante, L
Cavalli, P
Poggiani, C
Cavallari, U
Argiropoulos, B
Chernos, J
Brasch-Andersen, C
Speevak, M
Fichera, M
Ogilvie, CM
Shen, YP
Hodge, JC
Talkowski, ME
Stavropoulos, DJ
Marshall, CR
Scherer, SW
AF Lionel, Anath C.
Tammimies, Kristiina
Vaags, Andrea K.
Rosenfeld, Jill A.
Ahn, Joo Wook
Merico, Daniele
Noor, Abdul
Runke, Cassandra K.
Pillalamarri, Vamsee K.
Carter, Melissa T.
Gazzellone, Matthew J.
Thiruvahindrapuram, Bhooma
Fagerberg, Christina
Laulund, Lone W.
Pellecchia, Giovanna
Lamoureux, Sylvia
Deshpande, Charu
Clayton-Smith, Jill
White, Ann C.
Leather, Susan
Trounce, John
Bedford, H. Melanie
Hatchwell, Eli
Eis, Peggy S.
Yuen, Ryan K. C.
Walker, Susan
Uddin, Mohammed
Geraghty, Michael T.
Nikkel, Sarah M.
Tomiak, Eva M.
Fernandez, Bridget A.
Soreni, Noam
Crosbie, Jennifer
Arnold, Paul D.
Schachar, Russell J.
Roberts, Wendy
Paterson, Andrew D.
So, Joyce
Szatmari, Peter
Chrysler, Christina
Woodbury-Smith, Marc
Lowry, R. Brian
Zwaigenbaum, Lonnie
Mandyam, Divya
Wei, John
MacDonald, Jeffrey R.
Howe, Jennifer L.
Nalpathamkalam, Thomas
Wang, Zhuozhi
Tolson, Daniel
Cobb, David S.
Wilks, Timothy M.
Sorensen, Mark J.
Bader, Patricia I.
An, Yu
Wu, Bai-Lin
Musumeci, Sebastiano Antonino
Romano, Corrado
Postorivo, Diana
Nardone, Anna M.
Della Monica, Matteo
Scarano, Gioacchino
Zoccante, Leonardo
Novara, Francesca
Zuffardi, Orsetta
Ciccone, Roberto
Antona, Vincenzo
Carella, Massimo
Zelante, Leopoldo
Cavalli, Pietro
Poggiani, Carlo
Cavallari, Ugo
Argiropoulos, Bob
Chernos, Judy
Brasch-Andersen, Charlotte
Speevak, Marsha
Fichera, Marco
Ogilvie, Caroline Mackie
Shen, Yiping
Hodge, Jennelle C.
Talkowski, Michael E.
Stavropoulos, Dimitri J.
Marshall, Christian R.
Scherer, Stephen W.
TI Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males
for autism spectrum disorders, ADHD and other neurodevelopmental
phenotypes
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID COPY-NUMBER VARIATIONS; DE-NOVO MUTATIONS; GENOME-WIDE ASSOCIATION; E3
UBIQUITIN LIGASE; NEURONAL MIGRATION; MENTAL-RETARDATION; INTELLECTUAL
DISABILITY; BIPOLAR-DISORDER; EXONIC DELETIONS; RARE DELETIONS
AB Rare copy number variants (CNVs) disrupting ASTN2 or both ASTN2 and TRIM32 have been reported at 9q33.1 by genome-wide studies in a few individuals with neurodevelopmental disorders (NDDs). The vertebrate-specific astrotactins, ASTN2 and its paralog ASTN1, have key roles in glial-guided neuronalmigration during brain development. To determine the prevalence of astrotactin mutations and delineate their associated phenotypic spectrum, we screened ASTN2/TRIM32 and ASTN1 (1q25.2) for exonic CNVs in clinical microarray data from 89 985 individuals across 10 sites, including 64 114 NDD subjects. In this clinical dataset, we identified 46 deletions and 12 duplications affecting ASTN2. Deletions of ASTN1 were much rarer. Deletions near the 3' terminus of ASTN2, which would disrupt all transcript isoforms (a subset of these deletions also included TRIM32), were significantly enriched in the NDD subjects (P = 0.002) compared with 44 085 population-based controls. Frequent phenotypes observed in individuals with such deletions include autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), speech delay, anxiety and obsessive compulsive disorder (OCD). The 3'-terminal ASTN2 deletions were significantly enriched compared with controls in males with NDDs, but not in females. Upon quantifying ASTN2 human brain RNA, we observed shorter isoforms expressed from an alternative transcription start site of recent evolutionary origin near the 3' end. Spatiotemporal expression profiling in the human brain revealed consistently high ASTN1 expression while ASTN2 expression peaked in the early embryonic neocortex and postnatal cerebellar cortex. Our findings shed new light on the role of the astrotactins in psychopathology and their interplay in human neurodevelopment.
C1 [Lionel, Anath C.; Tammimies, Kristiina; Vaags, Andrea K.; Merico, Daniele; Gazzellone, Matthew J.; Thiruvahindrapuram, Bhooma; Pellecchia, Giovanna; Lamoureux, Sylvia; Yuen, Ryan K. C.; Walker, Susan; Uddin, Mohammed; Mandyam, Divya; Wei, John; MacDonald, Jeffrey R.; Howe, Jennifer L.; Nalpathamkalam, Thomas; Wang, Zhuozhi; Marshall, Christian R.; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada.
[Lionel, Anath C.; Tammimies, Kristiina; Vaags, Andrea K.; Merico, Daniele; Gazzellone, Matthew J.; Thiruvahindrapuram, Bhooma; Pellecchia, Giovanna; Lamoureux, Sylvia; Yuen, Ryan K. C.; Walker, Susan; Uddin, Mohammed; Arnold, Paul D.; Paterson, Andrew D.; Mandyam, Divya; Wei, John; MacDonald, Jeffrey R.; Howe, Jennifer L.; Nalpathamkalam, Thomas; Wang, Zhuozhi; Marshall, Christian R.; Scherer, Stephen W.] Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, Canada.
[Carter, Melissa T.] Hosp Sick Children, Div Clin & Metab Genet, Toronto, ON M5G 1X8, Canada.
[Lionel, Anath C.; Gazzellone, Matthew J.; Marshall, Christian R.; Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada.
[Lionel, Anath C.; Gazzellone, Matthew J.; Marshall, Christian R.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON M5S 1A8, Canada.
[Tammimies, Kristiina] Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, S-11330 Stockholm, Sweden.
[Vaags, Andrea K.; Argiropoulos, Bob; Chernos, Judy] Alberta Childrens Prov Gen Hosp, Cytogenet Lab, GLS South, Alberta Hlth Serv, Calgary, AB T3B 6A8, Canada.
[Lowry, R. Brian] Alberta Childrens Prov Gen Hosp, Dept Med Genet, Calgary, AB T3B 6A8, Canada.
[Lowry, R. Brian] Alberta Childrens Prov Gen Hosp, Dept Pediat, Calgary, AB T3B 6A8, Canada.
[Argiropoulos, Bob; Chernos, Judy] Univ Calgary, Alberta Childrens Hosp Res Inst Child & Maternal, Calgary, AB T3B 6A8, Canada.
[Vaags, Andrea K.] Calgary Lab Serv, Dept Anat Pathol & Cytopathol, Calgary, AB T2L 2K8, Canada.
[Rosenfeld, Jill A.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
[Ahn, Joo Wook; Deshpande, Charu; Ogilvie, Caroline Mackie] Guys & St Thomas NHS Fdn Trust, Cytogenet Dept & Clin Genet, London SE1 9RT, England.
[Noor, Abdul; Stavropoulos, Dimitri J.] Hosp Sick Children, Cytogenet Lab, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada.
[Noor, Abdul; So, Joyce; Speevak, Marsha; Stavropoulos, Dimitri J.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5T 1R8, Canada.
[Crosbie, Jennifer; Arnold, Paul D.; Schachar, Russell J.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada.
[Runke, Cassandra K.; Hodge, Jennelle C.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
[Runke, Cassandra K.; Hodge, Jennelle C.] Mayo Clin, Dept Med Genet, Rochester, MN 55905 USA.
[Pillalamarri, Vamsee K.; Talkowski, Michael E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
[Pillalamarri, Vamsee K.; Talkowski, Michael E.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02114 USA.
[Fagerberg, Christina; Brasch-Andersen, Charlotte] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark.
[Laulund, Lone W.; Brasch-Andersen, Charlotte] Odense Univ Hosp, Dept Paediat, DK-5000 Odense, Denmark.
[Clayton-Smith, Jill] St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester M13 9WL, Lancs, England.
[White, Ann C.] Brighton Gen Hosp, Sussex Community NHS Trust, Brighton BN2 3EW, E Sussex, England.
[Leather, Susan] Lewisham Healthcare NHS Trust, Community Paediat, London SE13 6LH, England.
[Trounce, John] Brighton & Sussex Univ Hosp NHS Trust, Brighton BN2 5BE, E Sussex, England.
[Bedford, H. Melanie] North York Gen Hosp, Genet Program, Toronto, ON M2K 1E1, Canada.
[Hatchwell, Eli; Eis, Peggy S.] Populat Diagnost Inc, Melville, NY 11747 USA.
[Geraghty, Michael T.; Nikkel, Sarah M.] Univ Ottawa, Dept Pediat, Ottawa, ON K1H 8L1, Canada.
[Geraghty, Michael T.; Nikkel, Sarah M.; Tomiak, Eva M.] Childrens Hosp Eastern Ontario, Dept Genet, Ottawa, ON K1H 8L1, Canada.
[Fernandez, Bridget A.] Mem Univ Newfoundland, Discipline Genet, St John, NF A1B 3V6, Canada.
[Fernandez, Bridget A.] Mem Univ Newfoundland, Discipline Med, St John, NF A1B 3V6, Canada.
[Soreni, Noam] St Josephs Healthcare, Anxiety Treatment & Res Ctr, Hamilton, ON L8P 3B6, Canada.
[Roberts, Wendy; Szatmari, Peter] Hosp Sick Children, Autism Res Unit, Toronto, ON M5G 1X8, Canada.
[Roberts, Wendy] Univ Toronto, Bloorview Res Inst, Toronto, ON M4G 1R8, Canada.
[So, Joyce; Szatmari, Peter] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada.
[Chrysler, Christina; Woodbury-Smith, Marc] McMaster Univ, Offord Ctr Child Studies, Dept Psychiat & Behav Neurosci, Hamilton, ON L8S 4K1, Canada.
[Zwaigenbaum, Lonnie] Univ Alberta, Dept Pediat, Edmonton, AB T5G 0B7, Canada.
[Tolson, Daniel; Cobb, David S.; Wilks, Timothy M.] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Sorensen, Mark J.] Kalispell Reg Med Ctr, Kalispell, MT 59901 USA.
[Bader, Patricia I.] Northeast Indiana Genet Counseling Ctr, Ft Wayne, IN 46845 USA.
[An, Yu; Wu, Bai-Lin] Fudan Univ, Childrens Hosp, Inst Biomed Sci, Shanghai 200032, Peoples R China.
[An, Yu; Wu, Bai-Lin] Fudan Univ, MOE Key Lab Contemporary Anthropol, Shanghai 200032, Peoples R China.
[Wu, Bai-Lin; Shen, Yiping] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
[Wu, Bai-Lin; Shen, Yiping] Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA.
[Musumeci, Sebastiano Antonino] IRCCS Oasi Maria SS, Neurol Unit, I-94018 Troina, Italy.
[Romano, Corrado] IRCCS Oasi Maria SS, Unit Pediat & Med Genet, I-94018 Troina, Italy.
[Fichera, Marco] IRCCS Oasi Maria SS, Med Genet Lab, I-94018 Troina, Italy.
[Postorivo, Diana; Nardone, Anna M.] Univ Roma Tor Vergata, Dept Med Genet, I-00133 Rome, Italy.
[Della Monica, Matteo; Scarano, Gioacchino] Gaetano Rummo Gen Hosp, Dept Med Genet, I-82100 Benevento, Italy.
[Zoccante, Leonardo] Univ Verona, GB Rossi Hosp, Dept Life Sci & Reprod, Child Neuropsychiat Unit, I-37126 Verona, Italy.
[Novara, Francesca; Zuffardi, Orsetta; Ciccone, Roberto] Univ Pavia, Dept Mol Med, I-27100 Pavia, Italy.
[Zuffardi, Orsetta] IRCCS C Mondino Natl Inst Neurol Fdn, I-27100 Pavia, Italy.
[Antona, Vincenzo] Univ Palermo, Dept Sci Hlth Promot & Mother & Child Care, I-90127 Palermo, Italy.
[Carella, Massimo; Zelante, Leopoldo] IRCCS Casa Sollievo Sofferenza, Med Genet Unit, I-71013 San Giovanni Rotondo, FG, Italy.
[Cavalli, Pietro; Cavallari, Ugo] AO Ist Ospitalieri Cremona, Genet Unit, I-26100 Cremona, Italy.
[Poggiani, Carlo] AO Ist Ospitalieri Cremona, Neonatal Intens Care Unit, I-26100 Cremona, Italy.
[Argiropoulos, Bob; Chernos, Judy] Univ Calgary, Dept Med Genet, Calgary, AB T2N 1N4, Canada.
[Speevak, Marsha] Credit Valley Hosp Site, Trillium Hlth Partners, Dept Genet, Mississauga, ON L5M 2N1, Canada.
[Fichera, Marco] Univ Catania, I-95123 Catania, Italy.
[Shen, Yiping] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai 200127, Peoples R China.
[Crosbie, Jennifer; Schachar, Russell J.] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada.
RP Scherer, SW (reprint author), Hosp Sick Children, Ctr Appl Genom, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM stephen.scherer@sickkids.ca
RI Romano, Corrado/B-9695-2008; Scherer, Stephen /B-3785-2013; Yuen,
Ryan/J-4876-2012
OI Romano, Corrado/0000-0003-1049-0683; Scherer, Stephen
/0000-0002-8326-1999;
FU University of Toronto McLaughlin Centre; NeuroDevNet; Genome Canada;
Ontario Genomics Institute; Canadian Institutes for Health Research
(CIHR); National Institutes of Health [MH095867]; Canadian Institute for
Advanced Research; Canada Foundation for Innovation; Government of
Ontario; Autism Speaks; The Hospital for Sick Children Foundation;
NeuroDevNet doctoral fellowship; Swedish Research Council; National
Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIDDK
Central Repositories; NIH Genes, Environment and Health Initiative [GEI]
[U01HG004399]; National Institutes of Health (NIH) [CA87969, CA55075,
DK58845]; NIH GEI [U01HG004424]; Division of Aging Biology, National
Institute on Aging; Division of Geriatrics and Clinical Gerontology,
National Institute on Aging; National Eye Institute; Center for
Inherited Disease Research (CIDR) [1 X01 HG005274-01]; Gene Environment
Association Studies (GENEVA) Coordinating Center [U01HG004446];
Collaborative Genetic Study of Nicotine Dependence (COGEND) [P01
CA089392]; University of Wisconsin Transdisciplinary Tobacco Use
Research Center [P50 DA019706, P50 CA084724]; National Institute of
Diabetes; Endocrinology and Metabolic Diseases of the NIDDK; NIH
FX This work was supported by grants from the University of Toronto
McLaughlin Centre, NeuroDevNet, Genome Canada and the Ontario Genomics
Institute, the Canadian Institutes for Health Research (CIHR), National
Institutes of Health (MH095867), the Canadian Institute for Advanced
Research, the Canada Foundation for Innovation, the Government of
Ontario, Autism Speaks and The Hospital for Sick Children Foundation. A.
C. L. was supported by a NeuroDevNet doctoral fellowship. K. T. holds a
post-doctoral fellowship from the Swedish Research Council. S. W. S.
holds the GlaxoSmithKline-CIHR Chair in Genome Sciences at the
University of Toronto and The Hospital for Sick Children. D. T., D. S.
C. and T. M. W. are US military service members and this work was
prepared as part of their official duties. The views expressed in this
article are those of the authors and do not necessarily reflect the
official policy or position of the Department of the Army, Department of
the Navy, Department of Defense, nor the US Government. Title 17, USC
105 provides that 'Copyright protection under this title is not
available for any work of the U.S. Government.' Title 17, USC 101
defines a US Government work as a work prepared by a military service
member or employee of the US Government as part of that person's
official duties. Control datasets were obtained, along with permission
for use, from the database of Genotypes and Phenotypes (dbGaP) found at
http://www.ncbi.nlm.nih.gov/gap through accession numbers
phs000143.v1.p1 (Starr County Health Studies' Genetics of Diabetes
Study), phs000091.v2.p1 (GENEVA NHS/HPFS Diabetes study),
phs000169.v1.p1 (Whole Genome Association Study of Visceral Adiposity in
the HABC Study), phs000303.v1.p1 (Genetic Epidemiology of Refractive
Error in the KORA Study), phs000404.v1.p1 (COGEND; The Genetic
Architecture of Smoking and Smoking Cessation) and phs000086.v2.p1
(DCCT-EDIC Clinical Trial and Follow-up of Persons with Type 1
Diabetes). The Starr County Health Studies Genetics of Diabetes Study
was supported by the National Institute of Diabetes and Digestive and
Kidney Diseases (NIDDK) and the NIDDK Central Repositories. Support for
the GWAS of Gene and Environment Initiatives in Type 2 Diabetes was
provided through the NIH Genes, Environment and Health Initiative [GEI]
(U01HG004399). The human subjects participating in the GWAS derive from
The Nurses' Health Study and Health Professionals' Follow-up Study and
these studies are supported by National Institutes of Health (NIH)
grants CA87969, CA55075 and DK58845. Assistance with phenotype
harmonization and genotype cleaning, as well as with general study
coordination, was provided by the Gene Environment Association Studies,
GENEVA Coordinating Center (U01 HG004446) and the National Center for
Biotechnology Information. Support for genotyping, which was performed
at the Broad Institute of MIT and Harvard, was provided by the NIH GEI
(U01HG004424). Support for the 'CIDR Visceral Adiposity Study' was
provided through the Division of Aging Biology and the Division of
Geriatrics and Clinical Gerontology, National Institute on Aging.
Assistance with phenotype harmonization and genotype cleaning, as well
as with general study coordination, was provided by Health ABC Study
HABC) Investigators. The KORA dataset was obtained from the NEI
Refractive Error Collaboration (NEIREC) Database, support for which was
provided by the National Eye Institute.Support for genotyping of the
COGEND samples, which was performed at the Center for Inherited Disease
Research (CIDR), was provided by 1 X01 HG005274-01. Assistance with
genotype cleaning of the COGEND samples, as well as with general study
coordination, was provided by the Gene Environment Association Studies
(GENEVA) Coordinating Center (U01HG004446). Support for the collection
of COGEND datasets and samples was provided by the Collaborative Genetic
Study of Nicotine Dependence (COGEND; P01 CA089392) and the University
of Wisconsin Transdisciplinary Tobacco Use Research Center (P50
DA019706, P50 CA084724). The DCCT-EDIC Research Group is sponsored
through research contracts from the National Institute of Diabetes,
Endocrinology and Metabolic Diseases of the NIDDK and the NIH. The
contents of this article are solely the responsibility of the authors
and do not necessarily represent the official views of the NIDDK or the
NIH.
CR Adam D, 2013, NATURE, V496, P416, DOI 10.1038/496416a
Adams NC, 2002, DEVELOPMENT, V129, P965
AHN JW, 2013, DATABASE OXFORD 0927, DOI DOI 10.1093/DATABASE/BAT067
Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4
Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
Banerjee A, 2010, BRAIN RES BULL, V83, P132, DOI 10.1016/j.brainresbull.2010.04.011
Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
Bernardini L, 2010, EUR J HUM GENET, V18, P178, DOI 10.1038/ejhg.2009.154
Beunders G, 2013, AM J HUM GENET, V92, P210, DOI 10.1016/j.ajhg.2012.12.011
Bis JC, 2012, NAT GENET, V44, P545, DOI 10.1038/ng.2237
Burbach JPH, 2009, TRENDS NEUROSCI, V32, P69, DOI 10.1016/j.tins.2008.11.002
Chen XL, 2013, AM J HUM GENET, V92, P375, DOI 10.1016/j.ajhg.2013.02.006
Chiang AP, 2006, P NATL ACAD SCI USA, V103, P6287, DOI 10.1073/pnas.0600158103
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Costain G, 2013, HUM MOL GENET, V22, P4485, DOI 10.1093/hmg/ddt297
Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429
Curran Sarah, 2013, J Mol Psychiatry, V1, P4, DOI 10.1186/2049-9256-1-4
Dabell MP, 2013, AM J MED GENET A, V161A, P717, DOI 10.1002/ajmg.a.35780
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Duong L, 2012, AM J MED GENET B, V159B, P354, DOI 10.1002/ajmg.b.32036
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
EDMONDSON JC, 1988, J CELL BIOL, V106, P505, DOI 10.1083/jcb.106.2.505
Ernst C, 2012, ARCH GEN PSYCHIAT, V69, P1238, DOI 10.1001/archgenpsychiatry.2012.660
Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
Fernandez TV, 2012, BIOL PSYCHIAT, V71, P392, DOI 10.1016/j.biopsych.2011.09.034
FISHELL G, 1991, DEVELOPMENT, V113, P755
Folsom TD, 2013, NEUROPHARMACOLOGY, V68, P122, DOI 10.1016/j.neuropharm.2012.08.015
Freilinger T, 2012, NAT GENET, V44, P777, DOI 10.1038/ng.2307
Frosk P, 2002, AM J HUM GENET, V70, P663, DOI 10.1086/339083
Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
Glessner JT, 2010, P NATL ACAD SCI USA, V107, P10584, DOI 10.1073/pnas.1000274107
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Grant SGN, 2012, CURR OPIN NEUROBIOL, V22, P522, DOI 10.1016/j.conb.2012.02.002
Grozeva D, 2010, ARCH GEN PSYCHIAT, V67, P318, DOI 10.1001/archgenpsychiatry.2010.25
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
Hampson DR, 2012, CLIN PHARMACOL THER, V91, P189, DOI 10.1038/clpt.2011.245
Hart H, 2012, NEUROSCI BIOBEHAV R, V36, P2248, DOI 10.1016/j.neubiorev.2012.08.003
Hodge J.C., 2013, MOL PSYCHIAT
Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jacques PE, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003504
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Kearney HM, 2011, GENET MED, V13, P680, DOI 10.1097/GIM.0b013e3182217a3a
Kudryashova E, 2009, HUM MOL GENET, V18, P1353, DOI 10.1093/hmg/ddp036
Lesch KP, 2008, J NEURAL TRANSM, V115, P1573, DOI 10.1007/s00702-008-0119-3
Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
Lionel AC, 2013, HUM MOL GENET, V22, P2055, DOI 10.1093/hmg/ddt056
Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Merico D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013984
Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Neri M, 2013, NEUROMUSCULAR DISORD, V23, P478, DOI 10.1016/j.nmd.2013.02.003
Noor A, 2010, SCI TRANSL MED, V2, p49ra68
O'Halloran CJ, 2012, J CLIN EXP NEUROPSYC, V34, P35, DOI 10.1080/13803395.2011.614599
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Pagnamenta AT, 2010, BIOL PSYCHIAT, V68, P320, DOI 10.1016/j.biopsych.2010.02.002
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Pescosolido Matthew F, 2012, Dialogues Clin Neurosci, V14, P239
Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Prasad A, 2012, G3-GENES GENOM GENET, V2, P1665, DOI 10.1534/g3.112.004689
Qin XY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036711
Ramocki MB, 2008, NATURE, V455, P912, DOI 10.1038/nature07457
Roohi J, 2009, J MED GENET, V46, P176, DOI 10.1136/jmg.2008.057505
Rosenfeld JA, 2013, GENET MED, V15, P478, DOI 10.1038/gim.2012.164
Sakurai T, 2012, MOL CELL NEUROSCI, V49, P351, DOI 10.1016/j.mcn.2011.12.002
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
Sato T, 2011, J CELL SCI, V124, P3492, DOI 10.1242/jcs.088799
Schaaf CP, 2012, EUR J HUM GENET, V20, P1240, DOI 10.1038/ejhg.2012.95
Scherer SW, 2011, HUM GENET, V130, P123, DOI 10.1007/s00439-011-1037-2
Schwamborn JC, 2009, CELL, V136, P913, DOI 10.1016/j.cell.2008.12.024
Shaikh TH, 2009, GENOME RES, V19, P1682, DOI 10.1101/gr.083501.108
Silversides CK, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002843
STITT TN, 1990, NEURON, V5, P639, DOI 10.1016/0896-6273(90)90218-5
Sudarov A, 2013, EMBO MOL MED, V5, P591, DOI 10.1002/emmm.201202106
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011
Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
Tropeano M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061365
Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025
Valdar WSJ, 2002, PROTEINS, V48, P227, DOI 10.1002/prot.10146
Valiente M, 2010, CURR OPIN NEUROBIOL, V20, P68, DOI 10.1016/j.conb.2009.12.003
van Daalen E, 2011, NEUROGENETICS, V12, P315, DOI 10.1007/s10048-011-0297-2
van Ewijk H, 2012, NEUROSCI BIOBEHAV R, V36, P1093, DOI 10.1016/j.neubiorev.2012.01.003
Vrijenhoek T, 2008, AM J HUM GENET, V83, P504, DOI 10.1016/j.ajhg.2008.09.011
Vulto-van Silfhout AT, 2013, HUM MUTAT, V34, P1679, DOI 10.1002/humu.22442
Wang KS, 2010, SCHIZOPHR RES, V124, P192, DOI 10.1016/j.schres.2010.09.002
Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
Wilson PM, 2010, J NEUROSCI, V30, P8529, DOI 10.1523/JNEUROSCI.0032-10.2010
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
Zheng C, 1996, SCIENCE, V272, P417, DOI 10.1126/science.272.5260.417
NR 99
TC 6
Z9 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD MAY 15
PY 2014
VL 23
IS 10
BP 2752
EP 2768
DI 10.1093/hmg/ddt669
PG 17
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AF4PB
UT WOS:000334694800020
PM 24381304
ER
PT J
AU Lawson, RP
Rees, G
Friston, KJ
AF Lawson, Rebecca P.
Rees, Geraint
Friston, Karl J.
TI An aberrant precision account of autism
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorder (ASD); predictive coding; precision; sensory
attenuation; learning; perception and action; sensory sensitivity;
social interaction
ID FIGURES TASK-PERFORMANCE; SUPERIOR VISUAL-SEARCH; SPECTRUM DISORDERS;
REPETITION SUPPRESSION; BINOCULAR-RIVALRY; BASAL FOREBRAIN; FREE-ENERGY;
MISMATCH NEGATIVITY; ACTIVE INFERENCE; COGNITIVE-STYLE
AB Autism is a neurodevelopmental disorder characterized by problems with social-communication, restricted interests and repetitive behavior. A recent and thoughtprovoking article presented a normative explanation for the perceptual symptoms of autism in terms of a failure of Bayesian inference (Pellicano and Burr, 2012). In response, we suggested that when Bayesian inference is grounded in its neural instantiation namely, predictive coding many features of autistic perception can be attributed to aberrant precision (or beliefs about precision) within the context of hierarchical message passing in the brain (Friston et al., 2013). Here, we unpack the aberrant precision account of autism. Specifically, we consider how empirical findings that speak directly or indirectly to neurobiological mechanisms are consistent with the aberrant encoding of precision in autism; in particular, an imbalance of the precision ascribed to sensory evidence relative to prior beliefs.
C1 [Lawson, Rebecca P.; Rees, Geraint; Friston, Karl J.] UCL, Wellcome Trust Ctr Neuroimaging, London WC1N 3BG, England.
[Rees, Geraint] UCL, Inst Cognit Neurosci, London WC1N 3BG, England.
RP Lawson, RP (reprint author), UCL, Wellcome Trust Ctr Neuroimaging, 12 Queen Sq, London WC1N 3BG, England.
EM rebecca.lawson@ucl.ac.uk
RI Rees, Geraint/C-1493-2008
OI Rees, Geraint/0000-0002-9623-7007
FU Wellcome Trust
FX This work was supported by the Wellcome Trust. We thank Chris Frith and
Camilla Nord for comments on earlier drafts of this manuscript.
CR Adams Rick A, 2013, Front Psychiatry, V4, P47, DOI 10.3389/fpsyt.2013.00047
Adams RA, 2013, BRAIN STRUCT FUNCT, V218, P611, DOI 10.1007/s00429-012-0475-5
Adams WJ, 2004, NAT NEUROSCI, V7, P1057, DOI 10.1038/nn1312
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Arnal LH, 2011, NAT NEUROSCI, V14, P797, DOI 10.1038/nn.2810
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Bastos AM, 2012, NEURON, V76, P695, DOI 10.1016/j.neuron.2012.10.038
Behrens TEJ, 2007, NAT NEUROSCI, V10, P1214, DOI 10.1038/nn1954
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Brock J, 2012, TRENDS COGN SCI, V16, P573, DOI 10.1016/j.tics.2012.10.005
Brown H, 2013, COGN PROCESS, V14, P411, DOI 10.1007/s10339-013-0571-3
Brown H, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00043
Ciranna L, 2006, CURR NEUROPHARMACOL, V4, P101, DOI 10.2174/157015906776359540
Corlett PR, 2009, PSYCHOPHARMACOLOGY, V206, P515, DOI 10.1007/s00213-009-1561-0
de Haas B, 2014, CURR BIOL, V24, pR66, DOI 10.1016/j.cub.2013.11.061
Denison RN, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00166
den Ouden HEM, 2010, J NEUROSCI, V30, P3210, DOI 10.1523/JNEUROSCI.4458-09.2010
Deutsch SI, 2010, CLIN NEUROPHARMACOL, V33, P114, DOI 10.1097/WNF.0b013e3181d6f7ad
Dichter GS, 2009, SOC COGN AFFECT NEUR, V4, P215, DOI 10.1093/scan/nsp017
Domes G, 2014, NEUROPSYCHOPHARMACOL, V39, P698, DOI 10.1038/npp.2013.254
Dunn MA, 2008, J AUTISM DEV DISORD, V38, P52, DOI 10.1007/s10803-007-0359-3
Ewbank MP, 2011, J NEUROSCI, V31, P5635, DOI 10.1523/JNEUROSCI.5013-10.2011
Feifel D, 1999, PSYCHOPHARMACOLOGY, V141, P93, DOI 10.1007/s002130050811
Feldman H, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00215
Friston KJ, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00130
Friston KJ, 2008, PLOS COMPUT BIOL, V4, DOI 10.1371/journal.pcbi.1000211
Friston KJ, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002327
Friston KJ, 2009, PHILOS T R SOC B, V364, P1211, DOI 10.1098/rstb.2008.0300
Friston KJ, 2005, PHILOS T R SOC B, V360, P815, DOI 10.1098/rstb.2005.1622
Friston KJ, 2002, PROG NEUROBIOL, V68, P113, DOI 10.1016/S0301-0082(02)00076-X
Friston KJ, 2013, TRENDS COGN SCI, V17, P1, DOI 10.1016/j.tics.2012.11.003
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031
Gandal MJ, 2012, GENES BRAIN BEHAV, V11, P740, DOI 10.1111/j.1601-183X.2012.00816.x
Garrido MI, 2009, CLIN NEUROPHYSIOL, V120, P453, DOI 10.1016/j.clinph.2008.11.029
Gilbert SJ, 2008, NEUROPSYCHOLOGIA, V46, P2281, DOI 10.1016/j.neuropsychologia.2008.03.025
Gomot M, 2012, INT J PSYCHOPHYSIOL, V83, P240, DOI 10.1016/j.ijpsycho.2011.09.017
Gomot M, 2011, J AUTISM DEV DISORD, V41, P705, DOI 10.1007/s10803-010-1091-y
Gordon I, 2013, P NATL ACAD SCI USA, V110, P20953, DOI 10.1073/pnas.1312857110
Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Harrington RA, 2013, AUTISM RES, V6, P149, DOI 10.1002/aur.1288
Haznedar MM, 1997, AM J PSYCHIAT, V154, P1047
Hohwy J, 2008, COGNITION, V108, P687, DOI 10.1016/j.cognition.2008.05.010
Horder J, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.53
Karvat G., 2013, NEUROPSYCHOPHARMACOL, V39, P831, DOI [10.1038/npp.2013.274, DOI 10.1038/NPP.2013.274.]
Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
Kleinhans NM, 2009, AM J PSYCHIAT, V166, P467, DOI 10.1176/appi.ajp.2008.07101681
Kok P, 2012, CEREB CORTEX, V22, P2197, DOI 10.1093/cercor/bhr310
Kolevzon A, 2006, J CLIN PSYCHIAT, V67, P407
LAKE CR, 1977, ARCH GEN PSYCHIAT, V34, P553
Lally N, 2014, NEUROIMAGE, V85, P823, DOI 10.1016/j.neuroimage.2013.07.049
Lane RD, 1998, J COGNITIVE NEUROSCI, V10, P525, DOI 10.1162/089892998562924
Larsson J, 2012, CEREB CORTEX, V22, P567, DOI 10.1093/cercor/bhr119
Lee PS, 2007, NEUROIMAGE, V38, P184, DOI 10.1016/j.neuroimage.2007.07.013
Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036
Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
Mathys C, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00039
McTighe SM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062189
Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018
Mitchell P, 2010, AUTISM RES, V3, P113, DOI 10.1002/aur.130
Mitchell P, 2004, INFANT CHILD DEV, V13, P185, DOI 10.1002/icd.348
Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
Moran RJ, 2013, J NEUROSCI, V33, P8227, DOI 10.1523/JNEUROSCI.4255-12.2013
Mottron L, 2009, PHILOS T R SOC B, V364, P1385, DOI 10.1098/rstb.2008.0333
Moutoussis M, 2014, CONSCIOUS COGN, V25, P67, DOI 10.1016/j.concog.2014.01.009
Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219
Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009
Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404
Pepeu G, 2004, LEARN MEMORY, V11, P21, DOI 10.1101/lm.68104
Perry E, 1999, TRENDS NEUROSCI, V22, P273, DOI 10.1016/S0166-2236(98)01361-7
Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058
Pinto L, 2013, NAT NEUROSCI, V16, P1857, DOI 10.1038/nn.3552
Posey DJ, 2008, J CLIN INVEST, V118, P6, DOI 10.1172/JCI32483
Purcell AE, 2001, NEUROLOGY, V57, P1618
RICHARD P, 1991, PHYSIOL REV, V71, P331
Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
Riva D, 2011, AM J NEURORADIOL, V32, P1430, DOI 10.3174/ajnr.A2527
Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
Robertson CE, 2013, J NEUROSCI, V 33, P16983, DOI 10.1523/JNEUROSCI.0448-13.2013
Robinson PD, 2001, AM J MED GENET, V100, P30, DOI 10.1002/ajmg.1187
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
Said CP, 2013, VISION RES, V77, P59, DOI 10.1016/j.visres.2012.11.002
Schwarzkopf DS, 2014, J NEUROSCI, V34, P2713, DOI 10.1523/JNEUROSCI.4416-13.2014
Series P, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00668
Shergill SS, 2014, JAMA PSYCHIAT, V71, P28, DOI 10.1001/jamapsychiatry.2013.2974
Shipp S, 2013, TRENDS NEUROSCI, V36, P706, DOI 10.1016/j.tins.2013.09.004
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Skewes JC, 2014, AUTISM, DOI [10.1177/1362361313519872, DOI 10.1177/1362361313519872]
Stephan KE, 2009, SCHIZOPHRENIA BULL, V35, P509, DOI 10.1093/schbul/sbn176
Stocker AA, 2006, NAT NEUROSCI, V9, P578, DOI 10.1038/nn1669
Summerfield C, 2008, NAT NEUROSCI, V11, P1004, DOI 10.1038/nn.2163
Todorovic A, 2012, J NEUROSCI, V32, P13389, DOI 10.1523/JNEUROSCI.2227-12.2012
van Boxtel JJA, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00019
Van de Cruys S, 2013, I-PERCEPTION, V4, P95, DOI 10.1068/i0580ic
Vossel S, 2014, CEREB CORTEX, V24, P1436, DOI 10.1093/cercor/bhs418
Walter E, 2009, J AUTISM DEV DISORD, V39, P339, DOI 10.1007/s10803-008-0630-2
Wang AT, 2006, BRAIN, V129, P932, DOI 10.1093/brain/awl032
Watanabe T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039561
White SJ, 2011, J AUTISM DEV DISORD, V41, P1565, DOI 10.1007/s10803-011-1182-4
Wing L, 1996, BRIT MED J, V312, P327
Yu AJ, 2005, NEURON, V46, P681, DOI 10.1016/j.neuron.2005.04.026
Yuhas J, 2011, J AUTISM DEV DISORD, V41, P248, DOI 10.1007/s10803-010-1040-9
NR 106
TC 4
Z9 4
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD MAY 14
PY 2014
VL 8
AR 302
DI 10.3389/fnhum.2014.00302
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AL9WI
UT WOS:000339493700001
PM 24860482
ER
PT J
AU Simpson, EA
Sclafani, V
Paukner, A
Hamel, AF
Novak, MA
Meyer, JS
Suomi, SJ
Ferrari, PF
AF Simpson, Elizabeth A.
Sclafani, Valentina
Paukner, Annika
Hamel, Amanda F.
Novak, Melinda A.
Meyer, Jerrold S.
Suomi, Stephen J.
Ferrari, Pier Francesco
TI Inhaled oxytocin increases positive social behaviors in newborn macaques
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE imitation recognition; neonatal imitation; individual differences
ID AUTISM SPECTRUM DISORDERS; INTRANASAL OXYTOCIN; PLASMA OXYTOCIN; RHESUS
MACAQUES; DOSE-RESPONSE; NEURAL BASIS; AFFILIATION; BRAIN; ATTENTION;
MONKEYS
AB Early caregiver-infant interactions are critical for infants' socioemotional and cognitive development. Several hormones and neuromodulators, including oxytocin, affect these interactions. Exogenous oxytocin promotes social behaviors in several species, including human and nonhuman primates. Although exogenous oxytocin increases social function in adults-including expression recognition and affiliation-it is unknown whether oxytocin can increase social interactions in infants. We hypothesized that nebulized oxytocin would increase affiliative social behaviors and such effects would be modulated by infants' social skills, measured earlier in development. We also hypothesized that oxytocin's effects on social behaviors may be due to its anxiolytic effects. We tested these hypotheses in a blind study by nebulizing 7- to 14-d-old macaques (n = 28) with oxytocin or saline. Following oxytocin administration, infants' facial gesturing at a human caregiver increased, and infants' salivary oxytocin was positively correlated with the time spent in close proximity to a caregiver. Infants' imitative skill (measured earlier in development: 1-7 d of age) predicted oxytocin-associated increases in affiliative behaviors-lip smacking, visual attention to a caregiver, and time in close proximity to a caregiver-suggesting that infants with higher propensities for positive social interactions are more sensitive to exogenous oxytocin. Oxytocin also decreased salivary cortisol, but not stress-related behaviors (e.g., scratching), suggesting the possibility of some anxiolytic effects. To our knowledge, this study provides the first evidence that oxytocin increases positive social behaviors in newborns. This information is of critical importance for potential interventions aimed at ameliorating inadequate social behaviors in infants with higher likelihood of developing neurodevelopmental disorder.
C1 [Simpson, Elizabeth A.; Paukner, Annika; Suomi, Stephen J.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Comparat Ethol Lab, Poolesville, MD 20837 USA.
[Simpson, Elizabeth A.; Sclafani, Valentina; Ferrari, Pier Francesco] Univ Parma, Dipartimento Neurosci, I-43100 Parma, Italy.
[Hamel, Amanda F.; Novak, Melinda A.; Meyer, Jerrold S.] Univ Massachusetts, Dept Psychol, Amherst, MA 01003 USA.
RP Simpson, EA (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Comparat Ethol Lab, Poolesville, MD 20837 USA.
EM simpsonea@mail.nih.gov
FU Division of Intramural Research, Eunice Kennedy Shriver National
Institute of Child Health and Human Development (NICHD), NICHD
[P01HD064653]; National Institutes of Health [RR11122]
FX We thank Ruth Woodward and Angela Ruggiero for technical assistance
administering oxytocin and collecting saliva. We thank Lydia Martin,
Grace Maloney, and Chris Catalfamo for behavioral reliability coding.
Thanks to Nathan Fox for feedback on an earlier version of this paper.
The Division of Intramural Research, Eunice Kennedy Shriver National
Institute of Child Health and Human Development (NICHD), NICHD Grant
P01HD064653 (to P.F.F.), and National Institutes of Health Grant RR11122
(to M.A.N.) supported this research.
CR Ainsworth M. S., 1974, GROWTH COMPETENCE, P97
Anagnostou E, 2014, BRAIN RES, V1580, P188, DOI 10.1016/j.brainres.2014.01.049
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Apter-Levi Y, 2014, BRAIN RES, V1580, P124, DOI 10.1016/j.brainres.2013.10.052
Arnstein D, 2011, J NEUROSCI, V31, P14243, DOI 10.1523/JNEUROSCI.0963-11.2011
Atzil S, 2014, SOC COGN AFFECT NEUR, V9, P1193, DOI 10.1093/scan/nst105
Bakermans-Kranenburg MJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.34
Bales KL, 2013, BIOL PSYCHIAT, V74, P180, DOI 10.1016/j.biopsych.2012.08.025
Bartz JA, 2011, TRENDS COGN SCI, V15, P301, DOI 10.1016/j.tics.2011.05.002
Cardoso C, 2013, PSYCHONEUROENDOCRINO, V38, P399, DOI 10.1016/j.psyneuen.2012.07.013
Carter CS, 2003, PHYSIOL BEHAV, V79, P383, DOI 10.1016/S0031-9384(03)00151-3
Chang SWC, 2014, BRAIN RES, V1580, P57, DOI 10.1016/j.brainres.2013.11.006
Chang SWC, 2012, P NATL ACAD SCI USA, V109, P959, DOI 10.1073/pnas.1114621109
Churchland PS, 2012, HORM BEHAV, V61, P392, DOI 10.1016/j.yhbeh.2011.12.003
Clark CL, 2013, PSYCHONEUROENDOCRINO, V38, P1208, DOI 10.1016/j.psyneuen.2012.10.017
Crockford C, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00068
Curley JP, 2005, TRENDS ECOL EVOL, V20, P561, DOI 10.1016/j.tree.2005.05.018
Dadds MR, 2014, J AUTISM DEV DISORD, V44, P521, DOI 10.1007/s10803-013-1899-3
Domes G, 2007, BIOL PSYCHIAT, V62, P1187, DOI 10.1016/j.biopsych.2007.03.025
Domes G, 2013, BIOL PSYCHIAT, V74, P164, DOI 10.1016/j.biopsych.2013.02.007
Ebitz RB, 2013, P NATL ACAD SCI USA, V110, P11630, DOI 10.1073/pnas.1305230110
Feldman R, 2007, CURR DIR PSYCHOL SCI, V16, P340, DOI 10.1111/j.1467-8721.2007.00532.x
Feldman R, 2007, PSYCHOL SCI, V18, P965, DOI 10.1111/j.1467-9280.2007.02010.x
Feldman R, 2012, HORM BEHAV, V61, P380, DOI 10.1016/j.yhbeh.2012.01.008
Ferrari PF, 2009, CHILD DEV, V80, P1057, DOI 10.1111/j.1467-8624.2009.01316.x
Ferrari PF, 2012, J COGNITIVE NEUROSCI, V24, P1165, DOI 10.1162/jocn_a_00198
Ferrari PF, 2009, CURR BIOL, V19, P1768, DOI 10.1016/j.cub.2009.08.055
Ferrari PF, 2006, PLOS BIOL, V4, P1501, DOI 10.1371/journal.pbio.0040302
Ferrari PF, 2009, PHILOS T R SOC LON B
Gordon I, 2013, P NATL ACAD SCI USA, V110, P20953, DOI 10.1073/pnas.1312857110
Guastella Adam J, 2012, Horm Behav, V61, P410, DOI 10.1016/j.yhbeh.2012.01.002
Guastella AJ, 2008, BIOL PSYCHIAT, V63, P3, DOI 10.1016/j.biopsych.2007.06.026
Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
Guastella AJ, 2013, PSYCHONEUROENDOCRINO, V38, P612, DOI 10.1016/j.psyneuen.2012.11.019
Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
Huang HP, 2014, NEUROPSYCHOPHARMACOL, V39, P1102, DOI 10.1038/npp.2013.310
INSEL TR, 1992, PSYCHONEUROENDOCRINO, V17, P3, DOI 10.1016/0306-4530(92)90073-G
Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
Kosaka H, 2012, BMC PSYCHIATRY, V12, P1
Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
LEGROS JJ, 1984, J CLIN ENDOCR METAB, V58, P105
Lenzi D, 2009, CEREB CORTEX, V19, P1124, DOI 10.1093/cercor/bhn153
Liu N, 2013, SOC NEUR M SAN DIEG
Lochhead JJ, 2012, ADV DRUG DELIVER REV, V64, P614, DOI 10.1016/j.addr.2011.11.002
Ludwig M, 2006, NAT REV NEUROSCI, V7, P126, DOI 10.1038/nrn1845
Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
Modi ME, 2012, HORM BEHAV, V61, P340, DOI 10.1016/j.yhbeh.2011.12.010
Modi M.E., 2014, PSYCHONEUROENDOCRINO
Neumann ID, 2013, PSYCHONEUROENDOCRINO, V38, P1985, DOI 10.1016/j.psyneuen.2013.03.003
Parr LA, 2013, PSYCHONEUROENDOCRINO, V38, P1748, DOI 10.1016/j.psyneuen.2013.02.011
Paukner A, 2009, SCIENCE, V325, P880, DOI 10.1126/science.1176269
Paukner A, 2005, BIOL LETTERS, V1, P219, DOI 10.1098/rsbl.2004.0291
Perry A, 2010, PSYCHONEUROENDOCRINO, V35, P1446, DOI 10.1016/j.psyneuen.2010.04.011
Rault JL, 2013, PHYSIOL BEHAV, V112, P40, DOI 10.1016/j.physbeh.2013.02.007
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
SCHINO G, 1991, PHARMACOL BIOCHEM BE, V38, P889, DOI 10.1016/0091-3057(91)90258-4
Schmid B, 2011, J PSYCHIATR RES, V45, P1387, DOI 10.1016/j.jpsychires.2011.05.010
Simpson EA, 2013, PLOS ONE, V8, P1
Simpson EA, 2014, PHILOS T R SOC B, V369, DOI 10.1098/rstb.2013.0289
Simpson EA, 2013, DEV PSYCHOBIOL, V56, P864
Smith AS, 2014, BIOL PSYCHIAT, V76, P281, DOI 10.1016/j.biopsych.2013.09.017
Solyst JA, 2013, SOC NEUR M SAN DIEG
Stavropoulos KKM, 2013, J CHILD PSYCHOL PSYC, V54, P603, DOI 10.1111/jcpp.12061
Stoop R, 2012, NEURON, V76, P142, DOI 10.1016/j.neuron.2012.09.025
Striepens N, 2013, SCI REP, V3, P1
Striepens N, 2011, FRONT NEUROENDOCRIN, V32, P426, DOI 10.1016/j.yfrne.2011.07.001
Swain JE, 2007, J CHILD PSYCHOL PSYC, V48, P262, DOI 10.1111/j.1469-7610.2007.01731.x
Tachibana M, 2013, J CHILD ADOL PSYCHOP, V23, P123, DOI 10.1089/cap.2012.0048
TRONICK E, 1978, J AM ACAD CHILD PSY, V17, P1, DOI 10.1016/S0002-7138(09)62273-1
van IJzendoorn MH, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00174
van Ijzendoorn MH, 2012, PSYCHONEUROENDOCRINO, V37, P438, DOI 10.1016/j.psyneuen.2011.07.008
Weisman O, 2012, PSYCHONEUROENDOCRINO, V37, P1582, DOI 10.1016/j.psyneuen.2012.02.014
Weisman O, 2013, BIOL LETTERS, V9, DOI 10.1098/rsbl.2013.0828
Weisman O, 2014, PROG NEURO-PSYCHOPH, V49, P47, DOI 10.1016/j.pnpbp.2013.11.006
Young LJ, 2013, BIOL PSYCHIAT, V74, P160, DOI 10.1016/j.biopsych.2013.05.015
Young LJ, 2002, BIOL PSYCHIAT, V51, P18, DOI 10.1016/S0006-3223(01)01268-9
NR 76
TC 7
Z9 7
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 13
PY 2014
VL 111
IS 19
BP 6922
EP 6927
DI 10.1073/pnas.1402471111
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AH0GS
UT WOS:000335798000049
PM 24778211
ER
PT J
AU Siniscalco, D
AF Siniscalco, Dario
TI The searching for autism biomarkers: a commentary on: a new methodology
of viewing extra-axial fluid and cortical abnormalities in children with
autism via transcranial ultrasonography
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism; transcranial ultrasonography; biomarkers; brain lesions and
behavior disturbances; neurotransmitter agents
C1 [Siniscalco, Dario] Univ Naples 2, Dept Expt Med, Naples, Italy.
[Siniscalco, Dario] Ctr Autism La Forza Silenzio, Caserta, Italy.
[Siniscalco, Dario] Cancellautismo, Florence, Italy.
RP Siniscalco, D (reprint author), Univ Naples 2, Dept Expt Med, Naples, Italy.
EM dariosin@uab.edu
CR Baio J., 2014, MMWR SURVEILL SUM S2, V63, P1
Bradstreet JJ, 2014, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00934
Siniscalco D, 2012, J AUTISM DEV DISORD, V42, P1403, DOI 10.1007/s10803-011-1373-z
Siniscalco D., 2013, AUTISM S, VS2, pe001, DOI DOI 10.4172/2165-7890.S2-E001
Siniscalco D., 2013, AUTISM, V3, pe119, DOI [10.4172/2165-7890.1000e119, DOI 10.4172/2165-7890.1000E119]
NR 5
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD MAY 12
PY 2014
VL 8
AR 240
DI 10.3389/fnhum.2014.00240
PG 2
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AH4XP
UT WOS:000336132600001
PM 24860465
ER
PT J
AU de Rezende, VB
Rosa, DV
Comim, CM
Magno, LAV
Rodrigues, ALS
Vidigal, P
Jeromin, A
Quevedo, J
Romano-Silva, MA
AF de Rezende, Vitor Bortolo
Rosa, Daniela Valadao
Comim, Clarissa Martinelli
Viana Magno, Luiz Alexandre
Severo Rodrigues, Ana Lucia
Vidigal, Paula
Jeromin, Andreas
Quevedo, Joao
Romano-Silva, Marco Aurelio
TI NCS-1 deficiency causes anxiety and depressive-like behavior with
impaired non-aversive memory in mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE NCS-1; Knockout; Behavior; Anxiety; Depression; Memory
ID NEURONAL CALCIUM SENSOR-1; INHIBITORY AVOIDANCE TASK; GENE; FREQUENIN;
PROTEIN; FACILITATION; EXPRESSION; PLASTICITY; DROSOPHILA; RECEPTOR
AB Sensing and regulating intracellular levels of calcium are essential for proper cellular function. In neurons, calcium sensing plays important roles in neuronal plasticity, neurotransmitter release, long-term synapse modification and ion channel activity. Neuronal calcium sensor-1 (NCS-1) is a member of the highly conserved neuronal calcium sensor family. Although NCS-1 has been associated with psychiatric conditions including autism, bipolar disorder and schizophrenia, it is unclear which role NCS-1 plays in behavior. To understand the involvement of NCS-1 in psychiatric conditions, we provided a comprehensive behavioral characterization of NCS-1 knockout (KO) mice. These mice grow and develop normally without apparent abnormalities in comparison to wild type littermates. However, open field showed that NCS-1 deficiency impairs novelty-induced exploratory activity in both KO and heterozygote (HT) mice. Moreover, NCS-1-deficiency also resulted in anxiety- and depressive-like behaviors as demonstrated by elevated plus maze, large open field, forced swim and tail suspension tasks. Furthermore, based on spontaneous object recognition test, non-aversive long-term memory was impaired in NCS-1 KO mice. In contrast, neither social behavior nor a kind of aversive memory was affected under NCS-1 deficiency. These data implicate NCS-1 in exploratory activity, memory and mood-related behaviors, suggesting that NCS-1 gene ablation may result in phenotypic abnormalities associated with neuropsychiatric disorders. (C) 2014 Elsevier Inc. All rights reserved.
C1 [de Rezende, Vitor Bortolo; Rosa, Daniela Valadao; Viana Magno, Luiz Alexandre; Romano-Silva, Marco Aurelio] Univ Fed Minas Gerais, Fac Med, Dept Saude Mental, Lab Neurociencia,INCT Med Mol, BR-30130100 Belo Horizonte, MG, Brazil.
[Vidigal, Paula] Univ Fed Minas Gerais, Fac Med, Dept Anat Patol & Med Legal, Lab Patol Mol, BR-30130100 Belo Horizonte, MG, Brazil.
[Comim, Clarissa Martinelli; Quevedo, Joao] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Neurociencias,INCT Translac Med, BR-88806000 Criciuma, SC, Brazil.
[Severo Rodrigues, Ana Lucia] Univ Fed Santa Catarina, Dept Bioquim, Ctr Ciencias Biol, Lab Neurobiol Depressao, BR-88040900 Florianopolis, SC, Brazil.
[Jeromin, Andreas] Banyan Biomarkers Inc, Alachua, FL 32615 USA.
RP Romano-Silva, MA (reprint author), Univ Fed Minas Gerais, Fac Med, Dept Saude Mental, Inst Nacl Ciencia & Tecnol,Lab Neurociencia, Av Alfredo Balena,190 Room 114, Belo Horizonte, MG, Brazil.
EM romano-silva@ufmg.br
RI Quevedo, Joao/E-5491-2013; Magno, Luiz Alexandre/B-1552-2010
OI Quevedo, Joao/0000-0003-3114-6611; Magno, Luiz
Alexandre/0000-0003-3693-1897
FU INCT-MM (FAPEMIG) [CBB-APQ-00075-09/CNPq 573646/2008-2]
FX Grant INCT-MM (FAPEMIG: CBB-APQ-00075-09/CNPq 573646/2008-2) supported
this work. We thank to Dr. Karen Torres, Dr. Bruno Sousa, M.Sc. Amy
Kowalski and Dr. Juliana Carten for critical review of the manuscript.
We also thank Dr. Maicon Albuquerque for providing statistical
assistance during our data analysis, and to Dr. Andreas Mullemann and
Dr. Horst Bluethmann (Hoffmann-La-Roche-Switzerland) for generating
NCS-1 knockout mouse. Dr. Andreas Jeromin is an employee of Banyan
Biomarkers, Inc. The other authors declare no conflict of interest in
all terms of editorial policy section.
CR Berridge MJ, 2000, NAT REV MOL CELL BIO, V1, P11, DOI 10.1038/35036035
Blasiole B, 2005, J NEUROBIOL, V64, P285, DOI 10.1002/neu.20138
Boehmerle W, 2007, P NATL ACAD SCI USA, V104, P11103, DOI 10.1073/pnas.0701546104
Burgoyne RD, 2007, NAT REV NEUROSCI, V8, P182, DOI 10.1038/nrn2093
Choleris E, 2001, NEUROSCI BIOBEHAV R, V25, P235, DOI 10.1016/S0149-7634(01)00011-2
Coukell B, 2004, DEV GROWTH DIFFER, V46, P449
Genin A, 2001, NEUROSCIENCE, V106, P571, DOI 10.1016/S0306-4522(01)00301-3
Gierke P, 2004, BIOCHEM BIOPH RES CO, V323, P38, DOI 10.1016/j.bbrc.2004.08.055
Gomez M, 2001, NEURON, V30, P241, DOI 10.1016/S0896-6273(01)00276-8
Handley MTW, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010534
Jo J, 2008, NEURON, V60, P1095, DOI 10.1016/j.neuron.2008.10.050
Kabbani N, 2002, J NEUROSCI, V22, P8476
Koh PO, 2003, P NATL ACAD SCI USA, V100, P313, DOI 10.1073/pnas.232693499
LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180
Muhlemann A, FUNCTIONAL STUDY NEU
OLAFSSON P, 1995, P NATL ACAD SCI USA, V92, P8001, DOI 10.1073/pnas.92.17.8001
Piton A, 2008, HUM MOL GENET, V17, P3965, DOI 10.1093/hmg/ddn300
PONGS O, 1993, NEURON, V11, P15, DOI 10.1016/0896-6273(93)90267-U
PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
RIVOSECCHI R, 1994, J PHYSIOL-LONDON, V474, P223
Rosa DVF, 2010, BRAIN RES BULL, V82, P289, DOI 10.1016/j.brainresbull.2010.04.014
Saab BJ, 2009, NEURON, V63, P643, DOI 10.1016/j.neuron.2009.08.014
Schroder N, 2003, SYNAPSE, V49, P89, DOI 10.1002/syn.10210
Sippy T, 2003, NAT NEUROSCI, V6, P1031, DOI 10.1038/nn1117
Souza Bruno R, 2006, Dialogues Clin Neurosci, V8, P95
Stem L., 1985, PSYCHOPHARMACOLOGY B, V85, P367
Tsujimoto T, 2002, SCIENCE, V295, P2276, DOI 10.1126/science.1068278
Zarrindast MR, 2007, BEHAV PHARMACOL, V18, P289, DOI 10.1097/FBP.0b013e3281f520b0
NR 28
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 10
PY 2014
VL 130
BP 91
EP 98
DI 10.1016/j.physbeh.2014.03.005
PG 8
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA AI4XM
UT WOS:000336869900013
PM 24631552
ER
PT J
AU Iwata, K
Matsuzaki, H
Tachibana, T
Ohno, K
Yoshimura, S
Takamura, H
Yamada, K
Matsuzaki, S
Nakamura, K
Tsuchiya, KJ
Matsumoto, K
Tsujii, M
Sugiyama, T
Katayama, T
Mori, N
AF Iwata, Keiko
Matsuzaki, Hideo
Tachibana, Taro
Ohno, Koji
Yoshimura, Saori
Takamura, Hironori
Yamada, Kohei
Matsuzaki, Shinsuke
Nakamura, Kazuhiko
Tsuchiya, Kenji J.
Matsumoto, Kaori
Tsujii, Masatsugu
Sugiyama, Toshirou
Katayama, Taiichi
Mori, Norio
TI N-ethylmaleimide-sensitive factor interacts with the serotonin
transporter and modulates its trafficking: implications for
pathophysiology in autism
SO MOLECULAR AUTISM
LA English
DT Article
DE Serotonin transporter; NSF; Interaction; Membrane trafficking; Autism;
Post-mortem brain; Lymphocyte
ID PROTEIN-KINASE-C; BIOGENIC-AMINE TRANSPORTERS; HIGH-FUNCTIONING AUTISM;
DOPAMINE TRANSPORTER; SPECTRUM DISORDERS; GABA(A) RECEPTORS; SYNTAXIN
1A; 1ST-DEGREE RELATIVES; EPILEPTIC SEIZURES; RETARDED-CHILDREN
AB Background: Changes in serotonin transporter (SERT) function have been implicated in autism. SERT function is influenced by the number of transporter molecules present at the cell surface, which is regulated by various cellular mechanisms including interactions with other proteins. Thus, we searched for novel SERT-binding proteins and investigated whether the expression of one such protein was affected in subjects with autism.
Methods: Novel SERT-binding proteins were examined by a pull-down system. Alterations of SERT function and membrane expression upon knockdown of the novel SERT-binding protein were studied in HEK293-hSERT cells. Endogenous interaction of SERT with the protein was evaluated in mouse brains. Alterations in the mRNA expression of SERT (SLC6A4) and the SERT-binding protein in the post-mortem brains and the lymphocytes of autism patients were compared to nonclinical controls.
Results: N-ethylmaleimide-sensitive factor (NSF) was identified as a novel SERT-binding protein. NSF was co-localized with SERT at the plasma membrane, and NSF knockdown resulted in decreased SERT expression at the cell membranes and decreased SERT uptake function. NSF was endogenously co-localized with SERT and interacted with SERT. While SLC6A4 expression was not significantly changed, NSF expression tended to be reduced in post-mortem brains, and was significantly reduced in lymphocytes of autistic subjects, which correlated with the severity of the clinical symptoms.
Conclusions: These data clearly show that NSF interacts with SERT under physiological conditions and is required for SERT membrane trafficking and uptake function. A possible role for NSF in the pathophysiology of autism through modulation of SERT trafficking, is suggested.
C1 [Iwata, Keiko; Matsuzaki, Hideo] Univ Fukui, Res Ctr Child Mental Dev, Fukui 910, Japan.
[Iwata, Keiko; Matsuzaki, Hideo] Osaka Univ, United Grad Sch Child Dev, Dept Dev Funct Brain Act, Fukui, Japan.
[Iwata, Keiko; Matsuzaki, Hideo] Kanazawa Univ, Fukui, Japan.
[Iwata, Keiko; Matsuzaki, Hideo] Hamamatsu Univ, Sch Med, Fukui, Japan.
[Iwata, Keiko; Matsuzaki, Hideo] Chiba Univ, Fukui, Japan.
[Iwata, Keiko; Matsuzaki, Hideo] Univ Fukui, Fukui 910, Japan.
[Matsuzaki, Hideo; Tsuchiya, Kenji J.; Matsumoto, Kaori; Tsujii, Masatsugu; Mori, Norio] Hamamatsu Univ, Sch Med, Res Ctr Child Mental Dev, Hamamatsu, Shizuoka, Japan.
[Tachibana, Taro; Yoshimura, Saori] Osaka City Univ, Grad Sch Engn, Dept Bioengn, Osaka 558, Japan.
[Ohno, Koji] Hamamatsu Univ, Sch Med, Dept Anat, Hamamatsu, Shizuoka, Japan.
[Takamura, Hironori; Yamada, Kohei; Matsuzaki, Shinsuke; Katayama, Taiichi] Osaka Univ, United Grad Sch Child Dev, Dept Mol Brain Sci, Suita, Osaka, Japan.
[Takamura, Hironori; Yamada, Kohei; Matsuzaki, Shinsuke; Katayama, Taiichi] Kanazawa Univ, Suita, Osaka, Japan.
[Takamura, Hironori; Yamada, Kohei; Matsuzaki, Shinsuke; Katayama, Taiichi] Hamamatsu Univ, Sch Med, Suita, Osaka, Japan.
[Takamura, Hironori; Yamada, Kohei; Matsuzaki, Shinsuke; Katayama, Taiichi] Chiba Univ, Suita, Osaka, Japan.
[Takamura, Hironori; Yamada, Kohei; Matsuzaki, Shinsuke; Katayama, Taiichi] Univ Fukui, Suita, Osaka, Japan.
[Takamura, Hironori; Yamada, Kohei] Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, Suita, Osaka, Japan.
[Nakamura, Kazuhiko; Mori, Norio] Hamamatsu Univ, Sch Med, Dept Psychiat, Hamamatsu, Shizuoka, Japan.
[Tsujii, Masatsugu] Chukyo Univ, Fac Contemporary Sociol, Toyota, Japan.
[Sugiyama, Toshirou] Hamamatsu Univ, Sch Med, Dept Child & Adolescent Psychiat, Hamamatsu, Shizuoka, Japan.
RP Matsuzaki, H (reprint author), Univ Fukui, Res Ctr Child Mental Dev, Fukui 910, Japan.
EM matsuzah@u-fukui.ac.jp; katayama@ugscd.osaka-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
FX We thank Dr Jane Pickett, Director of Brain Resources and Data, Autism
Tissue Program, for facilitating brain tissue collection. Human tissue
was obtained from the National Institute of Child Health and Development
Brain and Tissue Bank for Developmental Disorders at the University of
Maryland, Baltimore, MD. Tissue samples were also provided by the
Harvard Brain Tissue Resource Center. Written informed consent was
obtained from the participants or their families for publication of this
manuscript and accompanying figures. We would like to thank all the
participants and families for their time and effort. We thank Heinrich
Betz for the generous supply of full-length rat SERT cDNA. We also thank
Masako Suzuki (Research Equipment Center, Hamamatsu University School of
Medicine) for the technical support of the mass spectrometry analysis.
This study was supported by a Grant-in-Aid for Scientific Research (C)
from the Ministry of Education, Culture, Sports, Science and Technology
of Japan to KI and a Grant-in-Aid for Scientific Research on Innovative
Areas from the Ministry of Education, Culture, Sports, Science and
Technology of Japan to HM. A part of this study is the result of
integrated research on neuropsychiatric disorders carried out under the
Strategic Research Program for Brain Sciences by the Ministry of
Education, Culture, Sports, Science and Technology of Japan.
CR ABRAMSON RK, 1989, J AUTISM DEV DISORD, V19, P397, DOI 10.1007/BF02212938
ANDERSON GM, 1987, J CHILD PSYCHOL PSYC, V28, P885, DOI 10.1111/j.1469-7610.1987.tb00677.x
Azmitia EC, 2011, NEUROPHARMACOLOGY, V60, P1347, DOI 10.1016/j.neuropharm.2011.02.002
Bauman AL, 2000, J NEUROSCI, V20, P7571
Blakely RD, 2000, CURR OPIN NEUROBIOL, V10, P328, DOI 10.1016/S0959-4388(00)00088-X
Bookout Angie L, 2003, Nucl Recept Signal, V1, pe012
Brooks-Kayal A, 2010, BRAIN DEV-JPN, V32, P731, DOI 10.1016/j.braindev.2010.04.010
Carneiro AM, 2002, J NEUROSCI, V22, P7045
Carneiro AMD, 2008, J CLIN INVEST, V118, P1544, DOI 10.1172/JCI33374
Carneiro AMD, 2006, J BIOL CHEM, V281, P24769, DOI 10.1074/jbc.M603877200
Chanrion B, 2007, P NATL ACAD SCI USA, V104, P8119, DOI 10.1073/pnas.0610964104
Chou WH, 2010, J NEUROSCI, V30, P13955, DOI 10.1523/JNEUROSCI.0270-10.2010
CIARANELLO RD, 1982, NEW ENGL J MED, V307, P181, DOI 10.1056/NEJM198207153070310
Ciccone MA, 2008, NEUROPHARMACOLOGY, V55, P763, DOI 10.1016/j.neuropharm.2008.06.018
Cong M, 2001, J BIOL CHEM, V276, P45145, DOI 10.1074/jbc.M106087200
Conroy J, 2004, MOL PSYCHIATR, V9, P587, DOI 10.1038/sj.mp.4001459
COOK EH, 1988, J AUTISM DEV DISORD, V18, P553, DOI 10.1007/BF02211873
Cook EH, 1997, MOL PSYCHIATR, V2, P247
Cook E H Jr, 1990, J Neuropsychiatry Clin Neurosci, V2, P268
Cross S, 2008, NEUROPSYCHOPHARMACOL, V33, P353, DOI 10.1038/sj.npp.1301406
Cupello A, 2008, NEUROCHEM RES, V33, P2263, DOI 10.1007/s11064-008-9708-7
Cupello A, 2005, NEUROCHEM RES, V30, P425, DOI 10.1007/s11064-005-2676-2
Czesak M, 2007, J NEUROSCI METH, V164, P59, DOI 10.1016/j.jneumeth.2007.03.002
Deonna T, 2006, EPILEPSIA, V47, P79, DOI 10.1111/j.1528-1167.2006.00697.x
Evers DM, 2010, NAT NEUROSCI, V13, P1199, DOI 10.1038/nn.2624
FARAJ BA, 1994, INT J IMMUNOPHARMACO, V16, P561, DOI 10.1016/0192-0561(94)90107-4
Favale E, 2003, SEIZURE-EUR J EPILEP, V12, P316, DOI 10.1016/S1059-1311(02)00315-1
FAVALE E, 1995, NEUROLOGY, V45, P1926
Fleming KG, 1998, J BIOL CHEM, V273, P15675, DOI 10.1074/jbc.273.25.15675
HANLEY HG, 1977, ARCH GEN PSYCHIAT, V34, P521
Hanley JG, 2002, NEURON, V34, P53, DOI 10.1016/S0896-6273(02)00638-4
Hanson PI, 1997, CELL, V90, P523, DOI 10.1016/S0092-8674(00)80512-7
Hay JC, 1997, CURR OPIN CELL BIOL, V9, P505, DOI 10.1016/S0955-0674(97)80026-9
Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
Huang SP, 2010, J NEUROSCI, V30, P9381, DOI 10.1523/JNEUROSCI.1207-10.2010
Iwata K, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-11
Jahn R, 2006, NAT REV MOL CELL BIO, V7, P631, DOI 10.1038/nrm2002
Jess U, 2002, BIOCHEM BIOPH RES CO, V294, P272, DOI 10.1016/S0006-291X(02)00460-6
Jorgensen S, 2008, J NEUROSCI METH, V169, P168, DOI 10.1016/j.jneumeth.2007.12.004
Kim SJ, 2002, MOL PSYCHIATR, V7, P278, DOI 10.1038/sj/mp/4001033
Kittler JT, 2001, MOL CELL NEUROSCI, V18, P13, DOI 10.1006/mcne.2001.1005
Kneussel M, 2002, BRAIN RES REV, V39, P74, DOI 10.1016/S0165-0173(02)00159-5
Lautenschlager M, 2000, NEUROSCIENCE, V99, P519, DOI 10.1016/S0306-4522(00)00222-0
Leil TA, 2004, J NEUROSCI, V24, P11429, DOI 10.1523/JNEUROSCI.3355-04.2004
Levisohn PM, 2007, EPILEPSIA, V48, P33, DOI 10.1111/j.1528-1167.2007.01399.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Maestrini E, 1999, AM J MED GENET, V88, P492, DOI 10.1002/(SICI)1096-8628(19991015)88:5<492::AID-AJMG11>3.0.CO;2-X
Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x
Matveeva EA, 2007, EPILEPSY RES, V73, P266, DOI 10.1016/j.eplepsyres.2006.11.003
McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P993
Mendez M. A., 2012, NEUROPHARMACOLOGY, V68, P195, DOI 10.1016/j.neuropharm.2012.04.008
Muller HK, 2006, J BIOL CHEM, V281, P28901, DOI 10.1074/jbc.M602848200
Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
Nakamura K, 2008, INT J NEUROPSYCHOPH, V11, P1073, DOI 10.1017/S1461145708009036
Nakamura K, 2011, PROG NEURO-PSYCHOPH, V35, P454, DOI 10.1016/j.pnpbp.2010.11.033
Nishimune A, 1998, NEURON, V21, P87, DOI 10.1016/S0896-6273(00)80517-6
Osten P, 1998, NEURON, V21, P99, DOI 10.1016/S0896-6273(00)80518-8
Purcell AE, 2001, NEUROLOGY, V57, P1618
Quick MW, 2002, INT J DEV NEUROSCI, V20, P219, DOI 10.1016/S0736-5748(02)00021-7
Quick MW, 2003, NEURON, V40, P537, DOI 10.1016/S0896-6273(03)00605-6
Ramoz N, 2006, BIOL PSYCHIAT, V60, P186, DOI 10.1016/j.biopsych.2006.01.009
Robinson MB, 2002, J NEUROCHEM, V80, P1, DOI 10.1046/j.0022-3042.2001.00698.x
Rocha L, 2007, PROG NEURO-PSYCHOPH, V31, P1208, DOI 10.1016/j.pnpbp.2007.04.014
ROTHMAN JE, 1994, NATURE, V372, P55, DOI 10.1038/372055a0
Sanyal S, 2001, NEUROREPORT, V12, P1363, DOI 10.1097/00001756-200105250-00015
SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
Schmitt-Ulms G, 2004, NAT BIOTECHNOL, V22, P724, DOI 10.1038/nbt969
Song I, 1998, NEURON, V21, P393, DOI 10.1016/S0896-6273(00)80548-6
Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
Sullivan PF, 2006, AM J MED GENET B, V141B, P261, DOI 10.1002/ajmg.b.30272
Sur C, 1997, P NATL ACAD SCI USA, V94, P7639, DOI 10.1073/pnas.94.14.7639
Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
Tsuruda PR, 2010, J PHARMACOL TOXICOL, V61, P192, DOI 10.1016/j.vascn.2009.12.003
Tuchman R, 2009, BRAIN DEV-JPN, V31, P95, DOI 10.1016/j.braindev.2008.09.009
Tuchman R, 2010, BRAIN DEV-JPN, V32, P719, DOI 10.1016/j.braindev.2010.05.007
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Wersinger C, 2009, NEUROSCI LETT, V453, P157, DOI 10.1016/j.neulet.2009.02.033
Wersinger C, 2006, EUR J NEUROSCI, V24, P55, DOI 10.1111/j.1460-9568.2006.04900.x
Zhao CX, 2007, FEBS LETT, V581, P2140, DOI 10.1016/j.febslet.2007.03.032
Zhao CX, 2012, BBA-MOL CELL RES, V1823, P159, DOI 10.1016/j.bbamcr.2011.06.003
NR 80
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 10
PY 2014
VL 5
AR 33
DI 10.1186/2040-2392-5-33
PG 18
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AH3YE
UT WOS:000336061400001
PM 24834316
ER
PT J
AU Eden, KE
de Vries, PJ
Moss, J
Richards, C
Oliver, C
AF Eden, Kate E.
de Vries, Petrus J.
Moss, Jo
Richards, Caroline
Oliver, Chris
TI Self-injury and aggression in tuberous sclerosis complex: cross syndrome
comparison and associated risk markers
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Aggression; ASD; Impulsivity; Pain; Repetitive/stereotyped behaviour;
Self-injury; Tuberous sclerosis complex
ID AUTISM SPECTRUM DISORDERS; DE-LANGE-SYNDROME; INTELLECTUAL DISABILITIES;
PROBLEM BEHAVIOR; DEVELOPMENTAL-DISABILITIES; CHALLENGING BEHAVIOR;
FUNCTIONAL-ANALYSIS; PSYCHOMETRIC PROPERTIES; COGNITIVE IMPAIRMENTS;
EARLY-CHILDHOOD
AB Background: Research reporting prevalence rates of self-injurious and aggressive behaviour in people with tuberous sclerosis complex (TSC) is limited. No studies have compared rates of these behaviours in TSC with those in other syndrome groups matched for degree of disability or investigated risk markers for these behaviours in TSC.
Methods: Data from the Challenging Behaviour Questionnaire were collected for 37 children, aged 4 to 15 years, with TSC. Odds ratios were used to compare rates of self-injury and aggression in children with TSC with children with idiopathic autism spectrum disorder (ASD), fragile X, Cornelia de Lange and Down syndromes. Characteristics were measured using the Mood Interest and Pleasure Questionnaire, the Activity Questionnaire, the Social Communication Questionnaire, the Repetitive Behaviour Questionnaire, the Wessex Behaviour Schedule and the revised Non-communicating Children Pain Checklist. Mann-Whitney U analyses were used to compare characteristics between individuals with self-injury and aggression and those not showing these behaviours.
Results: Rates of self-injury and aggression in TSC were 27% and 50%, respectively. These are high but not significantly different from rates in children with Down syndrome or other syndrome groups. Both self-injury and aggression were associated with stereotyped and pain-related behaviours, low mood, hyperactivity, impulsivity and repetitive use of language. Children who engaged in self-injury also had lower levels of interest and pleasure and showed a greater degree of `insistence on sameness' than children who did not self-injure. Aggression was associated with repetitive behaviour. The majority of these associations remained significant when the association with level of adaptive functioning was controlled for.
Conclusions: Behavioural profiles can be used to identify those most at risk of developing self-injury and aggression. Further research is warranted to understand the influence of such internal factors as mood, ASD symptomatology and pain on challenging behaviour in people with intellectual disability.
C1 [Eden, Kate E.; Moss, Jo; Richards, Caroline; Oliver, Chris] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
[de Vries, Petrus J.] Univ Cape Town, Div Child & Adolescent Psychiat, ZA-7700 Rondebosch, South Africa.
[Moss, Jo] UCL, Inst Cognit Neurosci, London WC1N 3AR, England.
RP Eden, KE (reprint author), Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
EM kate.eden1@gmail.com
RI Moss, Jo/C-8812-2009
FU Cerebra
FX Cerebra funded this project. The Tuberous Sclerosis Association helped
to recruit families of children with tuberous sclerosis complex. Many
members of the Cerebra Centre for Neurodevelopmental Disorders also
helped to collect and enter data for the comparison groups, including
Michelle Hooker and Sarah Duffay.
CR AHLSEN G, 1994, ARCH NEUROL-CHICAGO, V51, P76
Aman M., 1986, ABERRANT BEHAV CHECK
[Anonymous], 1993, CELL, V75, P1306
Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
Baker P, 1998, J AUTISM DEV DISORD, V28, P279, DOI 10.1023/A:1026004501631
Berg K., 2007, J POLICY PRACT INTEL, V4, P120, DOI DOI 10.1111/J.1741-1130.2007.00109.X
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Bhuiyan ZA, 2006, J MED GENET, V43, P568, DOI 10.1136/jmg.2005.038240
Bolton PF, 2002, BRAIN, V125, P1247, DOI 10.1093/brain/awf124
Breau LM, 2002, PAIN, V99, P349, DOI 10.1016/S0304-3959(02)00179-3
Breau LM, 2000, DEV MED CHILD NEUROL, V42, P609, DOI 10.1017/S0012162200001146
Breau LM, 2003, J PEDIATR-US, V142, P498, DOI 10.1067/mpd.2003.163
Bruno E, 2003, CARDIOL YOUNG, V13, P532
Burbidge C, 2008, ACTIVITY QUESTIONNAI
Burbidge C, 2010, J INTELL DISABIL RES, V54, P1078, DOI 10.1111/j.1365-2788.2010.01338.x
Carr E., 1995, MENTAL RETARDATION D, V1, P94, DOI DOI 10.1002/MRDD.1410010204
Carr EG, 2003, AM J MENT RETARD, V108, P117, DOI 10.1352/0895-8017(2003)108<0117:MDAABS>2.0.CO;2
Carr EG, 2007, J AUTISM DEV DISORD, V37, P413, DOI 10.1007/s10803-006-0176-0
CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
Carr EG, 2006, BEHAV MODIF, V30, P901, DOI 10.1177/0145445506290080
Chapman RS, 2000, MENT RETARD DEV D R, V6, P84, DOI 10.1002/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P
Collacott RA, 1998, BRIT J PSYCHIAT, V172, P85, DOI 10.1192/bjp.172.1.85
Cooper SA, 2009, J INTELL DISABIL RES, V53, P200, DOI 10.1111/j.1365-2788.2008.01060.x
Courtemanche A, 2012, J INTELL DISABIL RES, V56, P501, DOI 10.1111/j.1365-2788.2011.01492.x
Crino PB, 2006, NEW ENGL J MED, V355, P1345, DOI 10.1056/NEJMra055323
Crocker AG, 2006, J INTELL DISABIL RES, V50, P652, DOI 10.1111/j.1365-2788.2006.00815.x
Curatolo P, 2008, LANCET, V372, P657, DOI 10.1016/S0140-6736(08)61279-9
de Vries PJ, 2007, EUR CHILD ADOLES PSY, V16, P16, DOI 10.1007/s00787-006-0570-3
de Vries PJ, 2010, TUBEROUS SCLEROSIS C
de Vries PJ, 2007, NEW ENGL J MED, V356, P92
Duerden EG, 2012, J AUTISM DEV DISORD, V42, P2460, DOI 10.1007/s10803-012-1497-9
DURAND VM, 1991, J APPL BEHAV ANAL, V24, P251, DOI 10.1901/jaba.1991.24-251
Dykens EM, 2002, J INTELL DISABIL RES, V46, P484, DOI 10.1046/j.1365-2788.2002.00431.x
Eaves L.C., 2006, J DEV BEHAV PEDIATR, V27, P95, DOI DOI 10.1097/00004703-200604002-00007
Emerson E, 2001, CHALLENGING BEHAV AN
Fidler DJ, 2005, INFANT YOUNG CHILD, V18, P86
Field A., 2009, DISCOVERING STAT USI
Gutierrez GC, 1998, J AUTISM DEV DISORD, V28, P97, DOI 10.1023/A:1026032413811
Hanley GP, 2003, J APPL BEHAV ANAL, V36, P147, DOI 10.1901/jaba.2003.36-147
Hayes S, 2011, J INTELL DISABIL RES, V55, P182, DOI 10.1111/j.1365-2788.2010.01355.x
Hunt A, 1998, J APPL RES INTELLECT, V11, P227
Hyman P, 2002, AM J MENT RETARD, V107, P146, DOI 10.1352/0895-8017(2002)107<0146:SIBSRA>2.0.CO;2
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Joinson C, 2003, PSYCHOL MED, V33, P335, DOI 10.1017/S0033291702007092
Kopp CMC, 2008, EPILEPSY BEHAV, V13, P505, DOI 10.1016/j.yebeh.2008.05.010
Kushlick R, 1973, PSYCHOL MED, V3, P466
Langthorne P, 2008, AM J MENT RETARD, V113, P403, DOI 10.1352/2008.113:403-417
Leung Alexander K C, 2007, J Pediatr Health Care, V21, P108, DOI 10.1016/j.pedhc.2006.05.004
Lord C., 1999, AUTISM DIAGNOSTIC OB
McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
McGill P, 1999, J APPL BEHAV ANAL, V32, P393, DOI 10.1901/jaba.1999.32-393
Melzack R, 1965, SCIENCE, V150, P171
Merkel S I, 1997, Pediatr Nurs, V23, P293
Moss J, 2008, REPETITIVE BEHAV SCA
Moss J, 2009, J AUTISM DEV DISORD, V39, P572, DOI 10.1007/s10803-008-0655-6
Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
O'Callaghan FJK, 1998, LANCET, V351, P1490, DOI 10.1016/S0140-6736(05)78872-3
Oliver C, 2011, J AUTISM DEV DISORD, V41, P1019, DOI 10.1007/s10803-010-1125-5
PALMER J, 1982, BRIT J MENT SUBNORM, V28, P88
Petty J, 2005, CURR OPIN PSYCHIATR, V18, P484, DOI 10.1097/01.yco.0000179484.62391.dc
Rakowski SK, 2006, KIDNEY INT, V70, P1777, DOI 10.1038/sj.ki.5001853
Ramesh V, 2003, BIOCHEM SOC T, V31, P579, DOI 10.1042/BST0310579
Richards C, 2012, J INTELL DISABIL RES, V56, P476, DOI 10.1111/j.1365-2788.2012.01537.x
Ross E, 2008, MOOD INTEREST PLEASU
Ross E, 2003, BRIT J CLIN PSYCHOL, V42, P81, DOI 10.1348/014466503762842039
Ross E, 2002, J INTELL DISABIL RES, V46, P191, DOI 10.1046/j.1365-2788.2002.00397.x
Rutter M, 1995, AUTISM DIAGNOSTIC IN
Rutter M., 2003, SOCIAL COMMUNICATION
Sanlaville D, 2007, EUR J HUM GENET, V15, P389, DOI 10.1038/sj.ejhg.5201778
Smalley S, 1998, J AUTISM DEV DISORD, V28, P408
Staley BA, 2008, EPILEPSY BEHAV, V13, P650, DOI 10.1016/j.yebeh.2008.07.010
Symons FJ, 2009, RES DEV DISABIL, V30, P521, DOI 10.1016/j.ridd.2008.07.012
Symons FJ, 2005, PAIN, V117, P473, DOI 10.1016/j.pain.2005.07.010
Symons FJ, 2011, NEUROSCI BIOBEHAV R, V35, P1266, DOI 10.1016/j.neubiorev.2011.01.002
TAYLOR DV, 1993, AM J MENT RETARD, V97, P659
Tunnicliffe P, 2011, RES DEV DISABIL, V32, P404, DOI 10.1016/j.ridd.2010.12.008
vanSlegtenhorst M, 1997, SCIENCE, V277, P805
WEBB DW, 1992, BRIT MED J, V304, P1647
Woolf CJ, 2000, SCIENCE, V288, P1765, DOI 10.1126/science.288.5472.1765
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 80
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD MAY 10
PY 2014
VL 6
AR 10
DI 10.1186/1866-1955-6-10
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AH1FU
UT WOS:000335866000001
PM 24822087
ER
PT J
AU deCastro, BR
AF deCastro, B. Rey
TI Acrolein and Asthma Attack Prevalence in a Representative Sample of the
United States Adult Population 2000-2009
SO PLOS ONE
LA English
DT Article
ID HAZARDOUS AIR-POLLUTANTS; AUTISM SPECTRUM DISORDERS; HEALTH INTERVIEW
SURVEY; TOXICS CONCENTRATIONS; OXIDATIVE STRESS; INHALED ACROLEIN;
RISK-ASSESSMENT; LUNG-FUNCTION; MAIN ROAD; POLLUTION
AB Background: Acrolein is an air toxic and highly potent respiratory irritant. There is little epidemiology available, but US EPA estimates that outdoor acrolein is responsible for about 75 percent of non-cancer respiratory health effects attributable to air toxics in the United States, based on the Agency's 2005 NATA (National-Scale Air Toxics Assessment) and acrolein's comparatively potent inhalation reference concentration of 0.02 mu g/m(3).
Objectives: Assess the association between estimated outdoor acrolein exposure and asthma attack reported by a representative cross-sectional sample of the adult United States population.
Methods: NATA 2005 chronic outdoor acrolein exposure estimates at the census tract were linked with residences oif adults (>= 18 years old) in the NHIS (National Health Interview Survey) 2000 - 2009 (n = 271,348 subjects). A sample-weighted logistic regression model characterized the association between the prevalence of reporting at least one asthma attack in the 12 months prior to survey interview and quintiles of exposure to outdoor acrolein, controlling for potential confounders.
Results: In the highest quintile of outdoor acrolein exposure (0.05 - 0.46 mu g/m(3)), there was a marginally significant increase in the asthma attack pOR (prevalence-odds ratio [95% CI] = 1.08 [0.98: 1.19]) relative to the lowest quintile. The highest quintile was also associated with a marginally significant increase in prevalence-odds (1.13 [0.98: 1.29]) in a model limited to never smokers (n = 153,820).
Conclusions: Chronic exposure to outdoor acrolein of 0.05 - 0.46 mg/m(3) appears to increase the prevalence-odds of having at least one asthma attack in the previous year by 8 percent in a representative cross-sectional sample of the adult United States population.
C1 Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30333 USA.
RP deCastro, BR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30333 USA.
EM rdecastro@cdc.gov
RI deCastro, Rey/G-2874-2011
OI deCastro, Rey/0000-0002-1610-5849
CR Abraham K, 2011, MOL NUTR FOOD RES, V55, P1277, DOI 10.1002/mnfr.201100481
Akinbami LJ, 2010, ENVIRON RES, V110, P294, DOI 10.1016/j.envres.2010.01.001
Alarie Y, 1973, CRC Crit Rev Toxicol, V2, P299, DOI 10.3109/10408447309082020
Alwis KU, 2012, ANAL CHIM A IN PRESS
Atkinson R., 1985, CHEM REV, V85, P69
ATSDR, 2007, TOX PROF ACR
Baumann LM, 2011, J ALLERGY CLIN IMMUN, V127, P875, DOI 10.1016/j.jaci.2010.11.031
Bein K, 2011, MOL NUTR FOOD RES, V55, P1342, DOI 10.1002/mnfr.201100279
BESWICK FW, 1983, HUM TOXICOL, V2, P247
BINDER DA, 1983, INT STAT REV, V51, P279, DOI 10.2307/1402588
Biswal S, 2003, CARCINOGENESIS, V24, P1401, DOI 10.1093/carcin/bgg061
Botman SL, 2000, DESIGN ESTIMATION NA
Brauer M, 2002, AM J RESP CRIT CARE, V166, P1092, DOI 10.1164/rccm.200108-007OC
CA Office of Environmental Health Hazard Assessment, 2008, AIR TOX HOT SPOTS RI
Cahill Thomas M, 2010, Res Rep Health Eff Inst, P3
CDC, 2010, NHI SURV DESCR
CDC, 2011, US SURV WEIGHTS LINK
CDC, 2010, MULT IMP FAM INC PER
CDC, 2000, NAT HLTH INT SURV
CDC, 2011, VAR EST OTH AN ISS N
CDC, 2009, VAR EST OTH AN ISS 1
CDC and NCHS (National Center for Health Statistics), 2010, HLTH US 2010
Cowell EM, 1939, BRIT MED J, V2, P736
Dorman DC, 2008, INHAL TOXICOL, V20, P205, DOI 10.1080/08958370701864151
Eastern Research Group, 2010, RES 2005 NATA MOD TO
EDNEY EO, 1986, INT J CHEM KINET, V18, P1355, DOI 10.1002/kin.550181207
Faroon O, 2008, TOXICOL IND HEALTH, V24, P447, DOI 10.1177/0748233708094188
Faroon O, 2008, TOXICOL IND HEALTH, V24, P543, DOI 10.1177/0748233708098124
Feng ZH, 2006, P NATL ACAD SCI USA, V103, P15404, DOI 10.1073/pnas.0607031103
Folsom RE, 2009, P JOINT STAT M 2000, P598
GDCh Advisory Committee on Existing Chemicals of Environmental Relevance (BUA), 1994, 157 BUA GDCH ADV COM
GRAFSTROM RC, 1988, CANCER RES, V48, P1717
Haag WR, 1988, ESTIMATION PHOTOLYSI
Health Effects Institute Air Toxics Review Panel, 2007, MOB SOURC AIR TOX CR
Hecht SS, 2006, P NATL ACAD SCI USA, V103, P15725, DOI 10.1073/pnas.0607811103
HILL AB, 1965, P ROY SOC MED, V58, P295
Hilmas CJ, 2008, MED ASPECTS CHEM WAR, P9
Holguin F, 2007, AM J RESP CRIT CARE, V176, P1236, DOI 10.1164/rccm.200611-1616OC
Howard PH., 1989, HDB ENV FATE EXPOSUR
International Agency for Research on Cancer, 1985, DRY CLEAN SOM CHL SO
Jomova K, 2010, MOL CELL BIOCHEM, V345, P91, DOI 10.1007/s11010-010-0563-x
Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76
Kan HD, 2007, THORAX, V62, P873, DOI 10.1136/thx.2006.073015
Kehrer JP, 2000, TOXICOL SCI, V57, P6, DOI 10.1093/toxsci/57.1.6
Kelly FJ, 2011, CLIN EXP ALLERGY, V41, P1059, DOI 10.1111/j.1365-2222.2011.03776.x
Kim JJ, 2008, ENVIRON HEALTH PERSP, V116, P1274, DOI 10.1289/ehp.10735
Leikauf GD, 2002, ENVIRON HEALTH PERSP, V110, P505
Leung G, 2011, NEUROSCIENCE, V173, P150, DOI 10.1016/j.neuroscience.2010.11.018
Linder SH, 2008, ENVIRON SCI TECHNOL, V42, P4312, DOI 10.1021/es072042u
Logue JM, 2010, J AIR WASTE MANAGE, V60, P271, DOI 10.3155/1047-3289.60.3.271
Logue JM, 2011, INDOOR AIR, V21, P92, DOI 10.1111/j.1600-0668.2010.00683.x
LoPachin RM, 2008, NEUROTOXICOLOGY, V29, P871, DOI 10.1016/j.neuro.2008.04.016
MacKay D, 1995, ILLUSTRATED HDB PHYS
Mason JB, 2011, ENVIRON SCI TECHNOL, V45, P2243, DOI 10.1021/es102500v
McCarthy MC, 2009, ENVIRON HEALTH PERSP, V117, P790, DOI 10.1289/ehp.11861
Monteil C, 1999, TOXICOLOGY, V133, P129, DOI 10.1016/S0300-483X(99)00015-3
Morgenstern V, 2008, AM J RESP CRIT CARE, V177, P1331, DOI 10.1164/rccm.200701-036OC
National Heart Lung and Blood Institute, 2012, WHAT IS ASTHM
National Heart Lung and Blood Institute, 1995, GLOB IN ASTHM
National Heart Lung and Blood Institute, 2007, GUID DIAGN MAN ASTHM
Nazaroff WW, 2004, J EXPO ANAL ENV EPID, V14, pS71, DOI 10.1038/sj.jea.7500361
Parker JD, 2009, ENVIRON HEALTH PERSP, V117, P140, DOI 10.1289/ehp.11497
Parker JD, 2008, ENVIRON RES, V106, P384, DOI 10.1016/j.envres.2007.11.001
Payne-Sturges DC, 2004, ENVIRON HEALTH PERSP, V112, P589
Pujades-Rodriguez M, 2009, OCCUP ENVIRON MED, V66, P679, DOI 10.1136/oem.2008.043885
Research Triangle Institute, 2008, SAS CALL SUDAAN
Rosenbaum AS, 1999, J AIR WASTE MANAGE, V49, P1138
Rubin DB, 2004, MULTIPLE IMPUTATION
Salam MT, 2008, CURR OPIN PULM MED, V14, P3, DOI 10.1097/MCP.0b013e3282f1987a
Schenker N, 2006, J AM STAT ASSOC, V101, P924, DOI 10.1198/016214505000001375
Schroeter JD, 2008, INHAL TOXICOL, V20, P227, DOI 10.1080/08958370701864235
Seaman VY, 2007, ENVIRON SCI TECHNOL, V41, P6940, DOI 10.1021/es0707299
Shi RY, 2011, MOL NUTR FOOD RES, V55, P1320, DOI 10.1002/mnfr.201100217
Shorter JH, 2012, ACROLEIN MONITOR USI
Singh M, 2010, J ALZHEIMERS DIS, V21, P741, DOI 10.3233/JAD-2010-100405
Stone V, 2000, AM J RESP CRIT CARE, V162, pS44
Stoner AM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075176
Struve MF, 2008, INHAL TOXICOL, V20, P217, DOI 10.1080/08958370701864219
Swift JL, 2006, 22 ANN NAT ENV MON C
Tanuma N, 2008, BRAIN DEV-JPN, V30, P402, DOI 10.1016/j.braindev.2007.12.001
Tuorinsky SD, 2008, MED ASPECTS CHEM WAR, P339
US Census Bureau, 2012, CENS TRACTS BLOCK NU
U.S. Environmental Protection Agency, 2010, TOX REL INV
U.S. Environmental Protection Agency E, 2003, TOX REV ACR
U.S. Environmental Protection Agency (EPA), 2011, 2005 NAT SCAL AIR TO
US EPA, 2010, EPA SCH MON IN FACT
US EPA, 2010, 2005 NAT EM INV DAT
US EPA, 2003, INT RISK INF SYST IR
US EPA, 2011, OV METH EPAS NAT SCA
US EPA, 1999, TO15 US EPA, Vsecond
US EPA, 2010, CLEAN AIR ACT AM 199
Venn AJ, 2001, AM J RESP CRIT CARE, V164, P2177, DOI 10.1164/rccm2106126
Voulgaridou GP, 2011, MUTAT RES-FUND MOL M, V711, P13, DOI 10.1016/j.mrfmmm.2011.03.006
Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
Woodruff TJ, 1998, ENVIRON HEALTH PERSP, V106, P245, DOI 10.1289/ehp.98106245
Woodruff TJ, 2007, ENVIRON HEALTH PERSP, V115, P410, DOI 10.1289/ehp.9467
NR 96
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 9
PY 2014
VL 9
IS 5
AR e96926
DI 10.1371/journal.pone.0096926
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AI4LX
UT WOS:000336838000080
PM 24816802
ER
PT J
AU Irwin, JR
Brancazio, L
AF Irwin, Julia R.
Brancazio, Lawrence
TI Seeing to hear? Patterns of gaze to speaking faces in children with
autism spectrum disorders
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE autism spectrum disorders; audiovisual speech perception; eyetracking;
communication development; speech in noise; lipreading
ID AUDIOVISUAL SPEECH-PERCEPTION; VISUAL INFLUENCES; EYE-TRACKING; EFFECT
SIZE; INFORMATION; INTEGRATION; INDIVIDUALS; STATISTICS; DESIGNS;
COMPETENCE
AB Using eye-tracking methodology, gaze to a speaking face was compared in a group of children with autism spectrum disorders (ASD) and a group with typical development (TD). Patterns of gaze were observed under three conditions: audiovisual (AV) speech in auditory noise, visual only speech and an AV non-face, non-speech control. Children with ASD looked less to the face of the speaker and fixated less on the speakers' mouth than TD controls. No differences in gaze were reported for the non-face, non-speech control task. Since the mouth holds much of the articulatory information available on the face, these findings suggest that children with ASD may have reduced access to critical linguistic information. This reduced access to visible articulatory information could be a contributor to the communication and language problems exhibited by children with ASD.
C1 [Irwin, Julia R.; Brancazio, Lawrence] Haskins Labs Inc, New Haven, CT 06511 USA.
[Irwin, Julia R.; Brancazio, Lawrence] So Connecticut State Univ, Dept Psychol, New Haven, CT 06515 USA.
RP Irwin, JR (reprint author), Haskins Labs Inc, 300 George St, New Haven, CT 06511 USA.
EM julia.irwin@haskins.yale.edu
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
Alcantara J. I., 2004, J CHILD PSYCHOL PSYC, V45, P1107, DOI [10.1111/j.1469-7610.2004.t01-1-00303.x, DOI 10.1111/J.1469-7610.2004.T01-1-00303.X]
Alsius A, 2005, CURR BIOL, V15, P839, DOI 10.1016/j.cub.2005.03.046
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bakeman R, 2005, BEHAV RES METHODS, V37, P379, DOI 10.3758/BF03192707
Bergeson T. R., 2004, HDB MULTISENSORY PRO, P749
Boraston Z, 2007, J PHYSIOL-LONDON, V581, P893, DOI 10.1113/jphysiol.2007.133587
Buchan JN, 2007, SOC NEUROSCI, V2, P1, DOI 10.1080/17470910601043644
Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
COHEN J, 1973, EDUC PSYCHOL MEAS, V33, P107, DOI 10.1177/001316447303300111
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220
Desjardins RN, 1997, J EXP CHILD PSYCHOL, V66, P85, DOI 10.1006/jecp.1997.2379
Elliott C. D., 1991, DIFFERENTIAL ABILITY
Falck-Ytter T, 2011, PROG BRAIN RES, V189, P209, DOI 10.1016/B978-0-444-53884-0.00026-9
Foxe JJ, 2015, CEREB CORTEX, V25, P298, DOI 10.1093/cercor/bht213
HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
HUTT C, 1966, BEHAV SCI, V11, P346, DOI 10.1002/bs.3830110504
Iarocci G, 2010, AUTISM, V14, P305, DOI 10.1177/1362361309353615
Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
Irwin JR, 2011, CHILD DEV, V82, P1397, DOI 10.1111/j.1467-8624.2011.01619.x
Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Lachs L, 2004, J ACOUST SOC AM, V116, P507, DOI 10.1121/1.1757454
Lachs L, 2001, EAR HEARING, V22, P236, DOI 10.1097/00003446-200106000-00007
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C., 2002, AUTISM DIAGNOSTIC OB
MACDONALD J, 1978, PERCEPT PSYCHOPHYS, V24, P253, DOI 10.3758/BF03206096
MacDonald J, 2000, PERCEPTION, V29, P1155, DOI 10.1068/p3020
Massaro D. W., 2003, J DEV LEARNING DISOR, V7, P111
MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0
Meltzoff A. N., 1994, DEV INTERSENSORY PER, P335
Menard L, 2009, J ACOUST SOC AM, V126, P1406, DOI 10.1121/1.3158930
Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y
Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
Olejnik S, 2003, PSYCHOL METHODS, V8, P434, DOI 10.1037/1082-989X.8.4.434
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
PHILLIPS W, 1992, DEV PSYCHOPATHOL, V4, P375, DOI 10.1017/S0954579400000845
Reisberg D., 1987, HEARING EYE PSYCHOL, P97
REMEZ RE, 1981, SCIENCE, V212, P947, DOI 10.1126/science.7233191
Saalasti S, 2012, J AUTISM DEV DISORD, V42, P1606, DOI 10.1007/s10803-011-1400-0
Semel E., 2003, CLIN EVALUATION LANG, V4th
Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001
Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x
Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
Sterling L, 2008, J AUTISM DEV DISORD, V38, P1666, DOI 10.1007/s10803-008-0550-1
SUMBY WH, 1954, J ACOUST SOC AM, V26, P212, DOI 10.1121/1.1907309
Thomas SM, 2004, J EXP PSYCHOL HUMAN, V30, P873, DOI 10.1037/0096-1523.30.5.873
Volkmar F. R., 1990, DEV PSYCHOPATHOL, V2, P61, DOI 10.1017/S0954579400000596
VOLKMAR FR, 1989, J CHILD PSYCHOL PSYC, V30, P591, DOI 10.1111/j.1469-7610.1989.tb00270.x
Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
Woynaroski TG, 2013, J AUTISM DEV DISORD, V43, P2891, DOI 10.1007/s10803-013-1836-5
Yi A, 2013, J SPEECH LANG HEAR R, V56, P471, DOI 10.1044/1092-4388(2012/10-0288)
NR 58
TC 2
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 8
PY 2014
VL 5
AR 397
DI 10.3389/fpsyg.2014.00397
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA AH2VW
UT WOS:000335981100001
PM 24847297
ER
PT J
AU Murdaugh, DL
Nadendla, KD
Kana, RK
AF Murdaugh, Donna L.
Nadendla, Kavita D.
Kana, Rajesh K.
TI Differential role of temporoparietal junction and medial prefrontal
cortex in causal inference in autism: An independent component analysis
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Autism; Independent component analysis; fMRI; Functional connectivity;
Theory of Mind
ID TEMPORO-PARIETAL JUNCTION; ASPERGER-SYNDROME; MIND; BRAIN; ATTRIBUTION;
PERFORMANCE; ACTIVATION; SPECTRUM; TASKS; FMRI
AB Neuroimaging studies have consistently identified a network of brain regions responsible for making inferences of others' mental states. This network includes the medial prefrontal cortex (MPFC), posterior superior temporal sulcus (pSTS) at the temporoparietal junction (TPJ), and temporal poles. Although TPJ and MPFC are key nodes of the Theory of Mind (ToM) network, their relative functional roles are still debated. This study sought to examine the contribution of these regions in causal attribution and to explore the nature of the ToM network in people with autism spectrum disorders (ASD). Participants watched a series of comic strip vignettes in the MRI scanner, and identified the most logical ending to each vignette, which sometimes required intentional causal attribution. Independent component analysis was done to isolate temporally correlated brain networks. The functional networks for intentional causality included the TPJ and MPFC, with an increased contribution of TPJ. There was also a significant group difference in the TPJ, with reduced response in participants with ASD. These results suggest an increased role of TPJ in intentional causality. In addition, the reduced response in ASD in TPJ may reflect their difficulties in social cognition. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Murdaugh, Donna L.; Nadendla, Kavita D.; Kana, Rajesh K.] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA.
RP Kana, RK (reprint author), Univ Alabama Birmingham, Dept Psychol, CIRC 235G,1719 6th Ave South, Birmingham, AL 35294 USA.
EM rkana@uab.edu
CR Apperly IA, 2007, COGNITION, V103, P300, DOI 10.1016/j.cognition.2006.04.012
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Brunet E, 2000, NEUROIMAGE, V11, P157, DOI 10.1006/nimg.1999.0525
Calhoun VD, 2008, HUM BRAIN MAPP, V29, P828, DOI 10.1002/hbm.20581
Calhoun VD, 2001, HUM BRAIN MAPP, V13, P43, DOI 10.1002/hbm.1024
Calhoun VD, 2002, HUM BRAIN MAPP, V16, P158, DOI 10.1002/hbm.10032
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Ciaramidaro A, 2007, NEUROPSYCHOLOGIA, V45, P3105, DOI 10.1016/j.neuropsychologia.2007.05.011
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
FLETCHER PC, 1995, COGNITION, V57, P109, DOI 10.1016/0010-0277(95)00692-R
Freire L, 2001, NEUROIMAGE, V14, P709, DOI 10.1006/nimg.2001.0869
Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
Gallagher HL, 2000, NEUROPSYCHOLOGIA, V38, P11, DOI 10.1016/S0028-3932(99)00053-6
Gweon H, 2012, CHILD DEV, V83, P1853, DOI 10.1111/j.1467-8624.2012.01829.x
Hagan E., 2012, SOC COGN AFFECT NEUR, V8, P694
Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040
HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510
Kana R.K., 2012, SCAN
Li YO, 2007, HUM BRAIN MAPP, V28, P1251, DOI 10.1002/hbm.20359
Lombardo MV, 2011, NEUROIMAGE, V56, P1832, DOI 10.1016/j.neuroimage.2011.02.067
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
McKeown MJ, 1998, HUM BRAIN MAPP, V6, P160, DOI 10.1002/(SICI)1097-0193(1998)6:3<160::AID-HBM5>3.0.CO;2-1
Sabatinelli D, 2011, NEUROIMAGE, V54, P2524, DOI 10.1016/j.neuroimage.2010.10.011
Saxe R, 2005, NEUROPSYCHOLOGIA, V43, P1391, DOI 10.1016/j.neuropsychologia.2005.02.013
Saxe R, 2006, SOC NEUROSCI, V1, P284, DOI 10.1080/17470910601000446
Saxe R, 2003, NEUROIMAGE, V19, P1835, DOI 10.1016/S1053-8119(03)00230-1
Saxe RR, 2009, CHILD DEV, V80, P1197, DOI 10.1111/j.1467-8624.2009.01325.x
Szameitat AJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038506
Young L, 2010, NEUROPSYCHOLOGIA, V48, P2658, DOI 10.1016/j.neuropsychologia.2010.05.012
NR 33
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 7
PY 2014
VL 568
BP 50
EP 55
DI 10.1016/j.neulet.2014.03.051
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA AH4QV
UT WOS:000336114000010
PM 24695086
ER
PT J
AU Sangha, S
Greba, Q
Robinson, PD
Ballendine, SA
Howland, JG
AF Sangha, Susan
Greba, Quentin
Robinson, Paul D.
Ballendine, Stephanie A.
Howland, John G.
TI Heightened fear in response to a safety cue and extinguished fear cue in
a rat model of maternal immune activation
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE fear conditioning; animal model; polyl:C; schizophrenia; reward;
prefrontal cortex; hippocampus; amygdala
ID PRENATAL EXPOSURE; BEHAVIORAL FLEXIBILITY; ADULT SCHIZOPHRENIA; PREPULSE
INHIBITION; ANIMAL-MODEL; EXTINCTION; INFECTION; MEMORY; MECHANISMS;
PREGNANCY
AB Maternal immune activation (MIA) during pregnancy is an environmental risk factor for psychiatric illnesses such as schizophrenia and autism in the offspring. Hence, changes in an array of behaviors, including behavioral flexibility, consistent with altered functioning of cortico-limbic circuits have been reported in rodent models of MIA. Surprisingly, previous studies have not examined the effect of MIA on the extinction of fear conditioning which depends on cortico-limbic circuits. Thus, we tested the effects of treating pregnant Long Evans rats with the viral mimetic polyl:C (gestational day 15; 4 mg/kg; i.v.) on fear conditioning and extinction in the male offspring using two different tasks. In the first experiment, we observed no effect of polyl:C treatment on the acquisition or extinction of a classically conditioned fear memory in a non-discriminative auditory cue paradigm. However, polyl:C-treated offspring did increase contextual freezing during the recall of fear extinction in this non-discriminative paradigm. The second experiment utilized a recently developed task to explicitly test the ability of rats to discriminate among cues signifying fear, reward, and safety; a task that requires behavioral flexibility. To our surprise, polyl:C-treated rats acquired the task in a manner similar to saline-treated rats. However, upon subsequent extinction training, they showed significantly faster extinction of the freezing response to the fear cue. In contrast, during the extinction recall test, polyl:C-treated offspring showed enhanced freezing behavior before and after presentation of the fear cue, suggesting an impairment in their ability to regulate fear behavior. These behavioral results are integrated into the literature suggesting impairments in cortico-limbic brain function in the offspring of rats treated with polyl:C during pregnancy.
C1 [Sangha, Susan; Greba, Quentin; Robinson, Paul D.; Ballendine, Stephanie A.; Howland, John G.] Univ Saskatchewan, Dept Physiol, Saskatoon, SK S7N 5E5, Canada.
RP Sangha, S (reprint author), Univ Saskatchewan, Dept Physiol, GB33,Hlth Sci Bldg,107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
EM sangha@purdue.edu; john.howland@usask.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC);
Canadian Institutes for Health Research (CIHR); NSERC; CIHR
FX This work was supported by a Discovery Grant from the Natural Sciences
and Engineering Research Council of Canada (NSERC) and Operating Grant
from the Canadian Institutes for Health Research (CIHR) to John G.
Howland. Paul D. Robinson was supported by an NSERC Undergraduate
Student Research Award. Stephanie A. Ballendine received support from a
CIHR Master's scholarship. John G. Howland is a CIHR New Investigator.
The authors thank Don A. Davies for contributing to video scoring.
CR BLANCHAR.RJ, 1969, J COMP PHYSIOL PSYCH, V67, P370, DOI 10.1037/h0026779
Bronson SL, 2011, BEHAV BRAIN RES, V220, P55, DOI 10.1016/j.bbr.2010.12.040
Brown AS, 2009, AM J PSYCHIAT, V166, P683, DOI 10.1176/appi.ajp.2008.08010089
Brown AS, 2011, SCHIZOPHRENIA BULL, V37, P284, DOI 10.1093/schbul/sbq146
Brown AS, 2012, DEV NEUROBIOL, V72, P1272, DOI 10.1002/dneu.22024
Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
Christianson JP, 2012, J NEUROSCI, V32, P14118, DOI 10.1523/JNEUROSCI.3340-12.2012
Corcoran KA, 2001, J NEUROSCI, V21, P1720
Dickerson Desiree D, 2013, Front Behav Neurosci, V7, P217, DOI 10.3389/fnbeh.2013.00217
Dickerson DD, 2010, J NEUROSCI, V30, P12424, DOI 10.1523/JNEUROSCI.3046-10.2010
Fineberg AM, 2013, BIOL PSYCHIAT, V73, P951, DOI 10.1016/j.biopsych.2013.01.001
Holt DJ, 2009, BIOL PSYCHIAT, V65, P455, DOI 10.1016/j.biopsych.2008.09.017
Holt DJ, 2012, ARCH GEN PSYCHIAT, V69, P893, DOI 10.1001/archgenpsychiatry.2011.2310
Howland JG, 2012, NEUROSCIENCE, V201, P184, DOI 10.1016/j.neuroscience.2011.11.011
Ji JZ, 2007, HIPPOCAMPUS, V17, P749, DOI 10.1002/hipo.20331
Khandaker GM, 2013, PSYCHOL MED, V43, P239, DOI 10.1017/S0033291712000736
Leeson VC, 2009, BIOL PSYCHIAT, V66, P586, DOI 10.1016/j.biopsych.2009.05.016
Lesting J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021714
Likhtik E, 2014, NAT NEUROSCI, V17, P106, DOI 10.1038/nn.3582
Maren S, 2004, NAT REV NEUROSCI, V5, P844, DOI 10.1038/nrn1535
Meyer U, 2014, BIOL PSYCHIAT, V75, P307, DOI 10.1016/j.biopsych.2013.07.011
Meyer U, 2012, NEUROPHARMACOLOGY, V62, P1308, DOI 10.1016/j.neuropharm.2011.01.009
Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
Morrow JD, 2011, BEHAV BRAIN RES, V220, P238, DOI 10.1016/j.bbr.2011.02.013
Myers KM, 2007, MOL PSYCHIATR, V12, P120, DOI 10.1038/sj.mp.4001939
Pantelis C, 1999, SCHIZOPHR RES, V37, P251, DOI 10.1016/S0920-9964(98)00156-X
Pearce BD, 2001, MOL PSYCHIATR, V6, P634, DOI 10.1038/sj.mp.4000956
Pecina S, 2006, BMC BIOL, V4, DOI 10.1186/1741-7007-4-8
Piontkewitz Y, 2012, NEUROPHARMACOLOGY, V62, P1273, DOI 10.1016/j.neuropharm.2011.04.019
Pollak DD, 2008, NEURON, V60, P149, DOI 10.1016/j.neuron.2008.07.041
Quirk GJ, 2008, NEUROPSYCHOPHARMACOL, V33, P56, DOI 10.1038/sj.npp.1301555
Rauch SL, 2006, BIOL PSYCHIAT, V60, P376, DOI 10.1016/j.biopsych.2006.06.004
Rogan MT, 2005, NEURON, V46, P309, DOI 10.1016/j.neuron.2005.02.017
Sangha S, 2014, NEUROPSYCHOPHARMACOL, V39, P2405, DOI 10.1038/npp.2014.89
Sangha S, 2013, J NEUROSCI, V33, P3744, DOI 10.1523/JNEUROSCI.3302-12.2013
Savanthrapadian S, 2013, HIPPOCAMPUS, V23, P1395, DOI 10.1002/hipo.22193
Schwendener S, 2009, J NEURODEV DISORD, V1, P15, DOI 10.1007/s11689-008-9000-9
Vorhees CV, 2012, SYNAPSE, V66, P725, DOI 10.1002/syn.21561
Wolff AR, 2010, BEHAV BRAIN RES, V213, P323, DOI 10.1016/j.bbr.2010.05.008
Wolff AR, 2008, BEHAV BRAIN RES, V190, P156, DOI 10.1016/j.bbr.2008.02.021
Yee N, 2012, J PSYCHIATR RES, V46, P1199, DOI 10.1016/j.jpsychires.2012.05.010
Zhang Y, 2012, NEUROPHARMACOLOGY, V62, P1299, DOI 10.1016/j.neuropharm.2011.02.022
Zuckerman L, 2003, NEUROPSYCHOPHARMACOL, V28, P1778, DOI 10.1038/sj.npp.1300248
Zuckerman L, 2005, J PSYCHIAT RES, V39, P311, DOI 10.1016/j.jpsychires.2004.08.008
NR 44
TC 2
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD MAY 7
PY 2014
VL 8
AR 168
DI 10.3389/fnbeh.2014.00168
PG 11
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AH2LR
UT WOS:000335953500001
PM 24847231
ER
PT J
AU Sandin, S
Lichtenstein, P
Kuja-Halkola, R
Larsson, H
Hultman, CM
Reichenberg, A
AF Sandin, Sven
Lichtenstein, Paul
Kuja-Halkola, Ralf
Larsson, Henrik
Hultman, Christina M.
Reichenberg, Abraham
TI The Familial Risk of Autism
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDER; SPECTRUM DISORDERS;
ENVIRONMENTAL-FACTORS; EPIDEMIOLOGIC SURVEY; RECURRENCE RISK; TWIN;
REGISTER; SCHIZOPHRENIA; HERITABILITY; GENETICS
AB IMPORTANCE Autism spectrum disorder (ASD) aggregates in families, but the individual risk and to what extent this is caused by genetic factors or shared or nonshared environmental factors remains
OBJECTIVE To provide estimates of familial aggregation and heritability of ASD.
DESIGN, SETTING, AND PARTICIPANTS A population-based cohort including 2 049 973 Swedish children born 1982 through 2006. We identified 37 570 twin pairs, 2 642 064 full sibling pairs, 432 281 maternal and 445 531 paternal half sibling pairs, and 5 799 875 cousin pairs. Diagnoses of ASD to December 31, 2009 were ascertained.
MAIN OUTCOMES AND MEASURES The relative recurrence risk (RRR) measures familial aggregation of disease. The RRR is the relative risk of autism in a participant with a sibling or cousin who has the diagnosis (exposed) compared with the risk in a participant with no diagnosed family member (unexposed). We calculated RRR for both ASD and autistic disorder adjusting for age, birth year, sex, parental psychiatric history, and parental age. We estimated how much of the probability of developing ASD can be related to genetic (additive and dominant) and environmental (shared and nonshared) factors.
RESULTS In the sample, 14 516 children were diagnosed with ASD, of whom 5689 had autistic disorder. The RRR and rate per 100 000 person-years for ASD among monozygotic twins was estimated to be 153.0 (95% CI, 56.7-412.8; rate, 6274 for exposed vs 27 for unexposed); for dizygotic twins, 8.2 (95% CI, 3.7-18.1; rate, 805 for exposed vs 55 for unexposed); for full siblings, 10.3 (95% CI, 9.4-11.3; rate, 829 for exposed vs 49 for unexposed); for maternal half siblings, 3.3 (95% CI, 2.6-4.2; rate, 492 for exposed vs 94 for unexposed); for paternal half siblings, 2.9 (95% CI, 2.2-3.7; rate, 371 for exposed vs 85 for unexposed); and for cousins, 2.0 (95% CI, 1.8-2.2; rate, 155 for exposed vs 49 for unexposed). The RRR pattern was similar for autistic disorder but of slightly higher magnitude. We found support for a disease etiology including only additive genetic and nonshared environmental effects. The ASD heritability was estimated to be 0.50 (95% CI, 0.45-0.56) and the autistic disorder heritability was estimated to 0.54 (95% CI, 0.44-0.64).
CONCLUSIONS AND RELEVANCE Among children born in Sweden, the individual risk of ASD and autistic disorder increased with increasing genetic relatedness. Heritability of ASD and autistic disorder were estimated to be approximately 50%. These findings may inform the counseling of families with affected children.
C1 [Sandin, Sven; Lichtenstein, Paul; Kuja-Halkola, Ralf; Larsson, Henrik; Hultman, Christina M.] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden.
[Sandin, Sven] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England.
[Reichenberg, Abraham] Ichan Sch Med Mt Sinai, Dept Psychiat, New York, NY USA.
[Reichenberg, Abraham] Ichan Sch Med Mt Sinai, Dept Prevent Med, New York, NY USA.
[Reichenberg, Abraham] Ichan Sch Med Mt Sinai, Seaver Autism Ctr, New York, NY USA.
[Reichenberg, Abraham] Ichan Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA.
RP Sandin, S (reprint author), Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden.
EM sven.sandin@ki.se
FU National Institutes of Health; Eunice Kennedy Shriver National Institute
of Child Health and Human Development, National Institute of
Environmental Health Sciences [HD073978]; National Institute of
Neurological Disorders and Stroke; National Institute of Mental Health
[MH097849]; Beatrice and Samuel A. Seaver Foundation
FX This study was supported, in part, by grants from the National
Institutes of Health; grant HD073978 from the Eunice Kennedy Shriver
National Institute of Child Health and Human Development, National
Institute of Environmental Health Sciences, and National Institute of
Neurological Disorders and Stroke; grant MH097849 from the National
Institute of Mental Health; and by the Beatrice and Samuel A. Seaver
Foundation.
CR Axelsson O, 2003, ACTA OBSTET GYN SCAN, V82, P491, DOI 10.1034/j.1600-0412.2003.00172.x
BAILEY A, 1995, PSYCHOL MED, V25, P63
Boker S, 2011, PSYCHOMETRIKA, V76, P306, DOI 10.1007/s11336-010-9200-6
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
Chudley AE, 1998, J DEV BEHAV PEDIATR, V19, P321, DOI 10.1097/00004703-199810000-00001
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
Ekbom A, 2011, METHODS MOL BIOL, V675, P215, DOI 10.1007/978-1-59745-423-0_10
Ekholm B, 2005, NORD J PSYCHIAT, V59, P457, DOI 10.1080/08039480500360906
FOLSTEIN S, 1977, NATURE, V265, P726, DOI 10.1038/265726a0
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
GRAMBSCH PM, 1994, BIOMETRIKA, V81, P515
Gronborg TK, 2013, JAMA PEDIATR, V167, P947, DOI 10.1001/jamapediatrics.2013.2259
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hollander E, 2010, TXB AUTISM SPECTRUM
Idring S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041280
Korn EL, 1997, AM J EPIDEMIOL, V145, P72
LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lichtenstein P, 2006, PSYCHOL MED, V36, P1417, DOI 10.1017/S0033291706008385
Lichtenstein P, 2006, TWIN RES HUM GENET, V9, P875, DOI 10.1375/183242706779462444
Lindstrom L, 2006, STAT MED, V25, P3110, DOI 10.1002/sim.2266
Ludvigsson JF, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-450
Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
RITVO ER, 1989, AM J PSYCHIAT, V146, P1032
Robinson EB, 2013, P NATL ACAD SCI USA, V110, P5258, DOI 10.1073/pnas.1211070110
Ronald A, 2011, MOL PSYCHIATR, V16, P1039, DOI 10.1038/mp.2010.82
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Sellgren C, 2011, ACTA PSYCHIAT SCAND, V124, P447, DOI 10.1111/j.1600-0447.2011.01747.x
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
Stone WS, 2011, N AM J MED SCI BOSTO, V4, P124
Sumi S, 2006, J HUM GENET, V51, P518, DOI 10.1007/s10038-006-0392-7
Szatmari P, 1998, J AUTISM DEV DISORD, V28, P351, DOI 10.1023/A:1026096203946
NR 34
TC 35
Z9 35
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 7
PY 2014
VL 311
IS 17
BP 1770
EP 1777
DI 10.1001/jama.2014.4144
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA AG4IG
UT WOS:000335382300022
PM 24794370
ER
PT J
AU Baron-Cohen, S
Murphy, L
Chakrabarti, B
Craig, I
Mallya, U
Lakatosova, S
Rehnstrom, K
Peltonen, L
Wheelwright, S
Allison, C
Fisher, SE
Warrier, V
AF Baron-Cohen, Simon
Murphy, Laura
Chakrabarti, Bhismadev
Craig, Ian
Mallya, Uma
Lakatosova, Silvia
Rehnstrom, Karola
Peltonen, Leena
Wheelwright, Sally
Allison, Carrie
Fisher, Simon E.
Warrier, Varun
TI A Genome Wide Association Study of Mathematical Ability Reveals an
Association at Chromosome 3q29, a Locus Associated with Autism and
Learning Difficulties: A Preliminary Study
SO PLOS ONE
LA English
DT Article
ID COGNITIVE-ABILITY; LOW PERFORMANCE; MICRODELETION; ACHIEVEMENT;
MICROARRAYS; DISABILITY; LINKAGE; DESIGN
AB Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability. We carried out a genome wide association scan using pooled DNA in two groups of U. K. samples, based on end of secondary/high school national academic exam achievement: high (n = 419) versus low (n = 183) mathematical ability while controlling for their verbal ability. Significant differences in allele frequencies between these groups were searched for in 906,600 SNPs using the Affymetrix GeneChip Human Mapping version 6.0 array. After meeting a threshold of p, P<1.5 x 10(-5), 12 SNPs from the pooled association analysis were individually genotyped in 542 of the participants and analyzed to validate the initial associations (lowest p-value 1.14 x 10(-6)). In this analysis, one of the SNPs (rs789859) showed significant association after Bonferroni correction, and four (rs10873824, rs4144887, rs12130910 rs2809115) were nominally significant (lowest p-value 3.278 x 10(-4)). Three of the SNPs of interest are located within, or near to, known genes (FAM43A, SFT2D1, C14orf64). The SNP that showed the strongest association, rs789859, is located in a region on chromosome 3q29 that has been previously linked to learning difficulties and autism. rs789859 lies 1.3 kbp downstream of LSG1, and 700 bp upstream of FAM43A, mapping within the potential promoter/regulatory region of the latter. To our knowledge, this is only the second study to investigate the association of genetic variants with mathematical ability, and it highlights a number of interesting markers for future study.
C1 [Baron-Cohen, Simon; Murphy, Laura; Chakrabarti, Bhismadev; Mallya, Uma; Lakatosova, Silvia; Wheelwright, Sally; Allison, Carrie; Warrier, Varun] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 1TN, Cambs, England.
[Baron-Cohen, Simon] Cambridgeshire & Peterborough NHS Fdn Trust CPFT, CLASS Clin, Cambridge, Cambs, England.
[Chakrabarti, Bhismadev] Univ Reading, Ctr Integrat Neurosci & Neurodynam, Sch Psychol & Clin Language Sci, Reading, Berks, England.
[Craig, Ian] Kings Coll London, Inst Psychiat, MRC, Ctr Social Genet & Dev Psychiat, London, England.
[Rehnstrom, Karola; Peltonen, Leena] Wellcome Trust Sanger Inst, Hinxton, Cambs, England.
[Fisher, Simon E.] Max Planck Inst Psycholinguist, NL-6500 AH Nijmegen, Netherlands.
[Fisher, Simon E.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
RP Baron-Cohen, S (reprint author), Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 1TN, Cambs, England.
EM sb205@cam.ac.uk; vw260@medschl.cam.ac.uk
RI Fisher, Simon/E-9130-2012
OI Fisher, Simon/0000-0002-3132-1996
FU Nancy Lurie Marks Family Foundation; Medical Research Council (MRC) UK;
Autism Research Trust (ART); Max Planck Society
FX This work was funded by grants to SBC from the Nancy Lurie Marks Family
Foundation, the Medical Research Council (MRC) UK, and the Autism
Research Trust (ART). LM and SEF were supported by the Max Planck
Society. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
CR Alarcon M, 2000, J SCHOOL PSYCHOL, V38, P63, DOI 10.1016/S0022-4405(99)00037-0
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2007, HUM NATURE-INT BIOS, V18, P125, DOI 10.1007/s12110-007-9014-0
Barratt BJ, 2002, ANN HUM GENET, V66, P393, DOI 10.1017/S0003480002001252
Davis OSP, 2009, BIOINFORMATICS, V25, P281, DOI 10.1093/bioinformatics/btn587
Docherty SJ, 2010, GENES BRAIN BEHAV, V9, P234, DOI 10.1111/j.1601-183X.2009.00553.x
Kovas Y, 2007, J LEARN DISABIL-US, V40, P554, DOI 10.1177/00222194070400060601
Mulle JG, 2010, AM J HUM GENET, V87, P229, DOI 10.1016/j.ajhg.2010.07.013
Nava C, 2014, EUR J HUM GENET, V22, P71, DOI 10.1038/ejhg.2013.88
Oliver B, 2004, J EDUC PSYCHOL, V96, P504, DOI 10.1037/0022-0663.96.3.504
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Purcell S, 2003, BIOINFORMATICS, V19, P149, DOI 10.1093/bioinformatics/19.1.149
Sagar A, 2013, AM J MED GENET A, V161A, P845, DOI 10.1002/ajmg.a.35754
Schosser Alexandra, 2010, BMC Res Notes, V3, P274, DOI 10.1186/1756-0500-3-274
WADSWORTH SJ, 1995, BEHAV GENET, V25, P1, DOI 10.1007/BF02197237
Wijsman EM, 2004, BEHAV GENET, V34, P51, DOI 10.1023/B:BEGE.0000009476.33020.b9
Willatt L, 2005, AM J HUM GENET, V77, P154, DOI 10.1086/431653
Yuan HY, 2006, NUCLEIC ACIDS RES, V34, pW635, DOI 10.1093/nar/gkl236
NR 18
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 6
PY 2014
VL 9
IS 5
AR e96374
DI 10.1371/journal.pone.0096374
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AJ9KS
UT WOS:000338029800063
PM 24801482
ER
PT J
AU Ogawa, LM
Vallender, EJ
AF Ogawa, Lisa M.
Vallender, Eric J.
TI Evolutionary conservation in genes underlying human psychiatric
disorders
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE schizophrenia; autism; Homo sapiens; adaptation
ID GENOME-WIDE ASSOCIATION; HUMAN BRAIN-SIZE; AUTISM SPECTRUM DISORDERS;
COPY NUMBER VARIATION; ADAPTIVE EVOLUTION; MOLECULAR EVOLUTION; LIFETIME
PREVALENCE; MAJOR DETERMINANT; BIPOLAR DISORDER; ANIMAL-MODELS
AB Many psychiatric diseases observed in humans have tenuous or absent analogs in other species. Most notable among these are schizophrenia and autism. One hypothesis has posited that these diseases have arisen as a consequence of human brain evolution, for example, that the same processes that led to advances in cognition, language, and executive function also resulted in novel diseases in humans when dysfunctional. Here, the molecular evolution of the protein-coding regions of genes associated with these and other psychiatric disorders are compared among species. Genes associated with psychiatric disorders are drawn from the literature and orthologous sequences are collected from eleven primate species (human, chimpanzee, bonobo, gorilla, orangutan, gibbon, macaque, baboon, marmoset, squirrel monkey, and galago) and 34 non-primate mammalian species. Evolutionary parameters, including d(N)/d(S), are calculated for each gene and compared between disease classes and among species, focusing on humans and primates compared to other mammals, and on large-brained taxa (cetaceans, rhinoceros, walrus, bear, and elephant) compared to their small-brained sister species. Evidence of differential selection in humans to the exclusion of non-human primates was absent, however elevated d(N)/d(S) was detected in catarrhines as a whole, as well as in cetaceans, possibly as part of a more general trend. Although this may suggest that protein changes associated with schizophrenia and autism are not a cost of the higher brain function found in humans, it may also point to insufficiencies in the study of these diseases including incomplete or inaccurate gene association lists and/or a greater role of regulatory changes or copy number variation. Through this work a better understanding of the molecular evolution of the human brain, the pathophysiology of disease, and the genetic basis of human psychiatric disease is gained.
C1 [Ogawa, Lisa M.; Vallender, Eric J.] Harvard Univ, Sch Med, Div Neurosci, New England Primate Res Ctr, Southborough, MA 01772 USA.
RP Vallender, EJ (reprint author), Harvard Univ, Sch Med, Div Neurosci, New England Primate Res Ctr, One Pine Hill Dr, Southborough, MA 01772 USA.
EM eric_vallender@hms.harvard.edu
FU National Institutes of Health [AA019688, OD011103]
FX This work was supported in part by grants from the National Institutes
of Health: AA019688 (to Eric J. Vallender) and OD011103. The authors
acknowledge helpful discussions with Dharmendra Goswami, Gregory Miller,
and Bertha Madras among others.
CR Aberg KA, 2013, JAMA PSYCHIAT, V70, P573, DOI 10.1001/jamapsychiatry.2013.288
Abrahams BS, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-36
Acland A, 2014, NUCLEIC ACIDS RES, V42, pD7, DOI 10.1093/nar/gkt1146
Akashi H, 2012, GENETICS, V192, P15, DOI 10.1534/genetics.112.140178
Allen NC, 2008, NAT GENET, V40, P827, DOI 10.1038/ng.171
Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
Becker KG, 2004, NAT GENET, V36, P431, DOI 10.1038/ng0504-431
Boddy AM, 2012, J EVOLUTION BIOL, V25, P981, DOI 10.1111/j.1420-9101.2012.02491.x
Boratyn GM, 2013, NUCLEIC ACIDS RES, V41, pW29, DOI 10.1093/nar/gkt282
Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
Burns Johnatan, 2006, Psychiatr Danub, V18, P225
Burns J. K., 2004, BEHAV BRAIN SCI, V27, P855, DOI 10.1017/S0140525X04000196
Burns JK, 2004, BEHAV BRAIN SCI, V27, P831
Carroll LS, 2009, GENOME MED, V1, DOI 10.1186/gm102
Claridge G., 1990, SOUNDS BELL JAR 10 P
Connor RC, 2007, PHILOS T R SOC B, V362, P587, DOI 10.1098/rstb.2006.1997
Cooper GM, 2007, NAT GENET, V39, pS22, DOI 10.1038/ng2054
Crespi B, 2007, P ROY SOC B-BIOL SCI, V274, P2801, DOI 10.1098/rspb.2007.0876
Crespi B, 2010, P NATL ACAD SCI USA, V107, P1736, DOI 10.1073/pnas.0906080106
Crespi BJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-15
Crow TJ, 1997, SCHIZOPHR RES, V28, P127, DOI 10.1016/S0920-9964(97)00110-2
Davis JM, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004241
de Lacy N, 2013, ANNU REV CLIN PSYCHO, V9, P555, DOI 10.1146/annurev-clinpsy-050212-185627
Dumas LJ, 2012, AM J HUM GENET, V91, P444, DOI 10.1016/j.ajhg.2012.07.016
Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
Enard W, 2002, NATURE, V418, P869, DOI 10.1038/nature01025
Evans PD, 2004, HUM MOL GENET, V13, P1139, DOI 10.1093/hmg/ddh126
Evans PD, 2004, HUM MOL GENET, V13, P489, DOI 10.1093/hmg/ddh055
Fanous AH, 2012, AM J PSYCHIAT, V169, P1309, DOI 10.1176/appi.ajp.2012.12020218
FARLEY JD, 1976, ACTA PSYCHIAT SCAND, V53, P173, DOI 10.1111/j.1600-0447.1976.tb00073.x
Fay JC, 2013, APPL T GENOMICS, V2, P42, DOI [DOI 10.1016/J.ATG.2013.08.001, 10.1016/j.atg.2013.08.001]
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Goldner EM, 2002, CAN J PSYCHIAT, V47, P833
Haygood R, 2007, NAT GENET, V39, P1140, DOI 10.1038/ng2104
Horrobin DF, 1998, MED HYPOTHESES, V50, P269, DOI 10.1016/S0306-9877(98)90000-7
Jia P, 2010, MOL PSYCHIATR, V15, P453, DOI 10.1038/mp.2009.93
KARLSSON JL, 1984, HEREDITAS, V100, P83, DOI 10.1111/j.1601-5223.1984.tb00108.x
Kessler RC, 2009, EPIDEMIOL PSICHIAT S, V18, P23
Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
KING MC, 1975, SCIENCE, V188, P107, DOI 10.1126/science.1090005
Kouprina N, 2004, PLOS BIOL, V2, P653, DOI 10.1371/journal.pbio.0020126
Larkin MA, 2007, BIOINFORMATICS, V23, P2947, DOI 10.1093/bioinformatics/btm404
Levinson DF, 2012, AM J PSYCHIAT, V169, P963, DOI [10.1176/appl.ajp.2012.11091423, 10.1176/appi.ajp.2012.11091423]
Lewis CM, 2003, AM J HUM GENET, V73, P34, DOI 10.1086/376549
Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
McGowen MR, 2012, P ROY SOC B-BIOL SCI, V279, P3643, DOI 10.1098/rspb.2012.0869
Meredith RW, 2011, SCIENCE, V334, P521, DOI 10.1126/science.1211028
Moalic JM, 2010, CURR MED CHEM, V17, P1300
Need AC, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000373
NEI M, 1986, MOL BIOL EVOL, V3, P418
Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
Nettle D., 2001, STRONG IMAGINATION M
Ng MYM, 2009, MOL PSYCHIATR, V14, P774, DOI 10.1038/mp.2008.135
OHTA T, 1995, J MOL EVOL, V40, P56
Owen MJ, 2011, BRIT J PSYCHIAT, V198, P173, DOI 10.1192/bjp.bp.110.084384
Peraala J, 2007, ARCH GEN PSYCHIAT, V64, P19, DOI 10.1001/archpsyc.64.1.19
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Popesco MC, 2006, SCIENCE, V313, P1304, DOI 10.1126/science.1127980
POST F, 1994, BRIT J PSYCHIAT, V165, P22, DOI 10.1192/bjp.165.1.22
Pruitt KD, 2014, NUCLEIC ACIDS RES, V42, pD756, DOI 10.1093/nar/gkt1114
Raychaudhuri S, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001097
Razafsha M, 2013, NEUROSCIENCE, V240, P204, DOI 10.1016/j.neuroscience.2013.02.045
Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
Ross CA, 2006, NEURON, V52, P139, DOI 10.1016/j.neuron.2006.09.015
Saha S, 2005, PLOS MED, V2, P413, DOI 10.1371/journal.pmed.0020141
Salyakina D, 2010, AUTISM RES, V3, P303, DOI 10.1002/aur.158
Seiffert ER, 2007, BMC EVOL BIOL, V7, DOI 10.1186/1471-2148-7-224
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Steimer Thierry, 2011, Dialogues Clin Neurosci, V13, P495
Sun J, 2008, AM J MED GENET B, V147B, P1173, DOI 10.1002/ajmg.b.30743
Sun JC, 2009, BIOINFORMATICS, V25, P2595, DOI 10.1093/bioinformatics/btp428
Tsang KM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076978
Vallender EJ, 2009, METHODS, V49, P50, DOI 10.1016/j.ymeth.2009.05.010
Vallender EJ, 2007, BMC EVOL BIOL, V7, DOI 10.1186/1471-2148-7-168
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Wang YQ, 2004, HUM MOL GENET, V13, P1131, DOI 10.1093/hmg/ddh127
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Yang ZH, 2007, MOL BIOL EVOL, V24, P1586, DOI 10.1093/molbev/msm088
Zhang JZ, 2003, GENETICS, V165, P2063
Zhang YQ, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-1
NR 84
TC 2
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD MAY 6
PY 2014
VL 8
AR 283
DI 10.3389/fnhum.2014.00283
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AH4UB
UT WOS:000336122900001
PM 24834046
ER
PT J
AU Schilbach, L
AF Schilbach, Leonhard
TI On the relationship of online and offline social cognition
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE social interaction; social neuroscience; social cognition from an
observer's point of view; social cognition from an interactor's point of
view; developmental psychology
ID MIRROR NEURONS; EYE-MOVEMENTS; 2ND-PERSON NEUROSCIENCE; BRAIN; MIND;
SELF; SIMULATION; IMITATION; AUTISM; GAZE
AB Social neuroscience studies the neurobiological underpinnings of people making sense of people. Due to both conceptual and methodological constraints, the majority of studies in this field of research, however, has employed experimental paradigms that focus on social cognition from an observer's rather than from an interactor's point of view (offline vs. online social cognition). This calls for an increased effort to systematically investigate the neural bases of participation in real-time social interaction. In light of the ontogenetic primacy of social interaction over observation and the idea that neural networks established during social interaction may be "re-used" during observation, other important objectives of the field will be to relate new findings into the neural bases of social interaction to previous work investigating the neural bases of social observation as well as to find ways to directly compare the two.
C1 Univ Hosp Cologne, Dept Psychiat, D-50924 Cologne, Germany.
RP Schilbach, L (reprint author), Univ Hosp Cologne, Dept Psychiat, Kerpener Str 62, D-50924 Cologne, Germany.
EM leonhard.schilbach@uk-koeln.de
CR Anderson ML, 2010, BEHAV BRAIN SCI, V33, P245, DOI 10.1017/S0140525X10000853
Anderson NC, 2013, BEHAV RES METHODS, V45, P842, DOI 10.3758/s13428-012-0299-5
Baez-Mendoza R, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00233
Barisic I., 2013, P SIGCHI C HUM FACT
Carpendale JIM, 2004, BEHAV BRAIN SCI, V27, P79
Caspers S, 2010, NEUROIMAGE, V50, P1148, DOI 10.1016/j.neuroimage.2009.12.112
Charman T, 2000, COGNITIVE DEV, V15, P481, DOI 10.1016/S0885-2014(01)00037-5
Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
Di Paolo E, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00163
Dumas G, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012166
Dumas G, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00128
Engemann DA, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00148
Etzel JA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003690
Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692
Frith U, 2010, PHILOS T R SOC B, V365, P165, DOI 10.1098/rstb.2009.0160
Froese T, 2014, SCI REP-UK, V4, DOI 10.1038/srep03672
Gallese V, 2013, CORTEX, V49, P2954, DOI 10.1016/j.cortex.2013.09.008
Gallotti M, 2013, TRENDS COGN SCI, V17, P160, DOI 10.1016/j.tics.2013.02.002
Guionnet S, 2012, CEREB CORTEX, V22, P971, DOI 10.1093/cercor/bhr177
Heyes C, 2013, CORTEX, V49, P2946, DOI 10.1016/j.cortex.2013.07.002
Heyes C, 2010, NEUROSCI BIOBEHAV R, V34, P575, DOI 10.1016/j.neubiorev.2009.11.007
Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
Jermann P., 2010, P 24 ACM BCS C HUM C
Keysers C, 2007, TRENDS COGN SCI, V11, P194, DOI 10.1016/j.tics.2007.02.002
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Knops A, 2009, SCIENCE, V324, P1583, DOI 10.1126/science.1171599
Konvalinka I, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00215
Kriegeskorte N, 2006, P NATL ACAD SCI USA, V103, P3863, DOI 10.1073/pnas.0600244103
Linden DEJ, 2006, MOL PSYCHIATR, V11, P528, DOI 10.1038/sj.mp.4001816
McCullough James P Jr, 2011, Am J Psychother, V65, P225
Moore K, 2013, BEHAV BRAIN SCI, V36, P431, DOI 10.1017/S0140525X12002129
Ochsner KN, 2001, AM PSYCHOL, V56, P717, DOI 10.1037//0003-066X.56.9.717
Paulus FM, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00196
Peters J, 2009, J NEUROSCI, V29, P15727, DOI 10.1523/JNEUROSCI.3489-09.2009
Pfeiffer UJ, 2013, NEUROSCI BIOBEHAV R, V37, P2516, DOI 10.1016/j.neubiorev.2013.07.017
Pfeiffer UJ, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00022
Reddy V., 2008, INFANTS KNOW MINDS
Reddy V, 2003, TRENDS COGN SCI, V7, P397, DOI 10.1016/S1364-6613(03)00191-8
Richardson DC, 2007, PSYCHOL SCI, V18, P407, DOI 10.1111/j.1467-9280.2007.01914.x
Rietveld E, 2013, BEHAV BRAIN SCI, V36, P436, DOI 10.1017/S0140525X12002038
Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
Saito Daisuke N, 2010, Front Integr Neurosci, V4, P127, DOI 10.3389/fnint.2010.00127
Schilbach L, 2010, J COGNITIVE NEUROSCI, V22, P2702, DOI 10.1162/jocn.2009.21401
Schilbach L, 2012, AUTISM, V16, P151, DOI 10.1177/1362361311409258
Schilbach Leonhard, 2010, Nat Rev Neurosci, V11, P449, DOI 10.1038/nrn2805-c1
Schilbach L, 2013, BEHAV BRAIN SCI, V36, P393, DOI 10.1017/S0140525X12000660
Schilbach L, 2008, SOC NEUROSCI, V3, P37, DOI 10.1080/17470910701563228
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Timmermans B., 2013, SOCIAL COGNITION WE, V17, P160, DOI [10.1016/j.tics.2013.02.002, DOI 10.1016/J.TICS.2013.02.002]
Timmermans B, 2012, PHILOS T R SOC B, V367, P1412, DOI 10.1098/rstb.2011.0421
Tognoli E, 2007, P NATL ACAD SCI USA, V104, P8190, DOI 10.1073/pnas.0611453104
Tost H, 2012, NAT MED, V18, P211, DOI 10.1038/nm.2671
Vogeley K, 2001, NEUROIMAGE, V14, P170, DOI 10.1006/nimg.2001.0789
Waytz A, 2011, CURR DIR PSYCHOL SCI, V20, P197, DOI 10.1177/0963721411409007
Westermann G, 2007, DEVELOPMENTAL SCI, V10, P75, DOI 10.1111/j.1467-7687.2007.00567.x
Wilms M, 2010, SOC COGN AFFECT NEUR, V5, P98, DOI 10.1093/scan/nsq024
WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
Wittgenstein Ludwig, 2001, PHILOS INVESTIGATION
NR 58
TC 8
Z9 8
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD MAY 6
PY 2014
VL 8
AR 278
DI 10.3389/fnhum.2014.00278
PG 8
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AH4TY
UT WOS:000336122600001
PM 24834045
ER
PT J
AU Ozkubat, U
Ozdemir, S
AF Ozkubat, Ufuk
Ozdemir, Selda
TI A comparison of social skills in Turkish children with visual
impairments, children with intellectual impairments and typically
developing children
SO INTERNATIONAL JOURNAL OF INCLUSIVE EDUCATION
LA English
DT Article
DE visual impairments; intellectual impairments; inclusive education;
social skills
ID ELEMENTARY-SCHOOL CLASSROOMS; AUTISM SPECTRUM DISORDERS;
MENTAL-RETARDATION; BEHAVIOR PROBLEMS; PARENTING STRESS; INCLUSION;
DISABILITIES; ADOLESCENTS; INTEGRATION; ACCEPTANCE
AB The purpose of this study was to compare the social skills of five groups of children: children with visual impairments attending inclusive education schools, children with visual impairments attending schools for the blind, children with intellectual impairments attending inclusive education schools, children with intellectual impairments attending segregated special education schools, and typically developing children. A hundred and sixty-nine children aged from 7 to 12 participated in the study. The children's social skills were rated by their teachers on the Social Skills Rating System (SSRS) - Turkish Form. The results suggested significant group differences between children attending inclusive education schools and children attending special education schools. Analysis of the findings indicated that children with visual impairments and children with intellectual impairments had poorer social skills than typically developing children; however children with visual impairments and children with intellectual impairments attending inclusive education schools had higher social skills than children attending segregated special education schools. The findings of the study were discussed and suggestions for future research were provided.
C1 [Ozkubat, Ufuk; Ozdemir, Selda] Gazi Univ, Dept Special Educ, TR-06500 Ankara, Turkey.
RP Ozdemir, S (reprint author), Gazi Univ, Dept Special Educ, TR-06500 Ankara, Turkey.
EM seldaozdemir@gazi.edu.tr
CR Baker BL, 2002, AM J MENT RETARD, V107, P433, DOI 10.1352/0895-8017(2002)107<0433:BPAPSI>2.0.CO;2
Baker BL, 2003, J INTELL DISABIL RES, V47, P217, DOI 10.1046/j.1365-2788.2003.00484.x
Buhrow M. M., 1998, J VISUAL IMPAIRMENT, V92, P213
Bunch G, 2004, DISABIL SOC, V19, P61, DOI 10.1080/0968759032000155640
Cosbey JE, 2006, RES PRACT PERS SEV D, V31, P144
Diperna JC, 2005, PSYCHOL SCHOOLS, V42, P345, DOI 10.1002/pits.20095
Dowing J. E., 1996, INCLUDING STUDENTS S
Dymond K. S., 2001, FOCUS AUTISM OTHER D, V6, P54, DOI [10.1177/108835760101600113, DOI 10.1177/108835760101600113]
Einfeld SL, 1996, J INTELL DISABIL RES, V40, P99, DOI 10.1111/j.1365-2788.1996.tb00611.x
Fenty NS, 2008, INTERV SCH CLIN, V43, P186, DOI 10.1177/1053451207312922
Ferguson D. L, 2008, EUROPEAN J SPECIAL N, V23, P109, DOI DOI 10.1080/08856250801946236
Frederickson N., 2007, ED PSYCHOL PRACTICE, V23, P109, DOI [10.1080/02667360701320770, DOI 10.1080/02667360701320770]
FREUND LS, 1991, RES DEV DISABIL, V12, P435, DOI 10.1016/0891-4222(91)90037-S
Gresham F., 1988, ADV SCH PSYCHOL, V6, P203
Gresham F. M., 1990, SOCIAL SKILLS RATING
GRESHAM FM, 1987, J SPEC EDUC, V21, P167
Gresham FM, 1997, ED TREATMENT CHILDRE, V20, P233
Guralnick M. J., 2006, J POLICY PRACT INTEL, V3, P49, DOI DOI 10.1111/J.1741-1130.2006.00052.X
Hall JA, 1997, RES SOCIAL WORK PRAC, V7, P187
Hartup W. W., 1975, SCH PSYCHOL DIGEST, V4, P11
Hodges JS, 1999, J VISUAL IMPAIR BLIN, V93, P153
Huang WH, 1997, BEHAV MODIF, V21, P3, DOI 10.1177/01454455970211001
Jindal S. D., 2004, J VISUAL IMPAIRMENT, V98, P470
Jindal S. D., 2005, J VISUAL IMPAIRMENT, V99, P403
Jones AP, 2010, J AUTISM DEV DISORD, V40, P1094, DOI 10.1007/s10803-010-0957-3
Kargin T., 2004, OZEL EGITIM DERGISI, V5, P1
Kekelis L. S., 1992, PEER INTERACTIONS CH
Lane KL, 2004, J SPEC EDUC, V38, P104, DOI 10.1177/00224669040380020401
Lewis L, 2005, BRIT J EDUC TECHNOL, V36, P739, DOI 10.1111/j.1467-8535.2005.00504.x
Luiselli J. K., 2005, J APPL SCH PSYCHOL, V21, P21, DOI [10.1300/J370v21n01_02, DOI 10.1300/J370V21N01_]
MacCuspie P. A., 1996, PROMOTING ACCEPTANCE
Macintosh K, 2006, J AUTISM DEV DISORD, V36, P1065, DOI 10.1007/s10803-006-0139-5
Mahoney G., 2008, SYNDROME RES PRACTIC, V13, P47
Manetti M, 2001, INT J BEHAV DEV, V25, P279
Mathews TL, 2009, CHILD FAM BEHAV THER, V31, P270, DOI 10.1080/07317100903333160
McGaha CG, 2001, J VISUAL IMPAIR BLIN, V95, P80
Meimer C. R., 2006, ED TREATMENT CHILDRE, V29, P409
Merrell K. W., 2001, EXCEPTIONALITY, V9, P3, DOI DOI 10.1207/S15327035EX091&2_2
Miller M. J., 2005, PREVENTING SCH FAILU, V49, P27, DOI [10.3200/PSFL.49.2.27-39, DOI 10.3200/PSFL.49.2.27-39]
Odluyurt S, 2010, KURAM UYGULAMA EGI, V10, P1563
Odom SL, 2000, TOP EARLY CHILD SPEC, V20, P20, DOI 10.1177/027112140002000104
ODOM SL, 1990, TOP EARLY CHILD SPEC, V10, P48
Peters S. J., 2004, INCLUSIVE ED EFA STR
Polat F, 2011, INT J EDUC DEV, V31, P50, DOI 10.1016/j.ijedudev.2010.06.009
Rich E. C., 2008, ED TREATMENT CHILDRE, V31, P183, DOI [10.1353/etc.0.0026, DOI 10.1353/ETC.0.0026]
Rosenblum LP, 1998, J VISUAL IMPAIR BLIN, V92, P593
Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
Ruijs NM, 2009, EDUC RES REV-NETH, V4, P67, DOI 10.1016/j.edurev.2009.02.002
Rutherford R. B., 1992, TEACHING SOCIAL SKIL
Sandieson R., 2002, INT J DISABIL DEV ED, V49, P243, DOI [10.1080/1034912022000007270, DOI 10.1080/1034912022000007270]
Sargent L. R., 1991, SOCIAL SKILLS SCH CO
Schut R. B., 1991, J VISUAL IMPAIRMENT, V85, P340
Silver CH, 1999, DEV NEUROPSYCHOL, V16, P117, DOI 10.1207/S15326942DN160107
Sucuoglu B., 2005, OZEL EGITIM DERGISI, V6, P41
Symes W, 2010, SCHOOL PSYCHOL INT, V31, P478, DOI 10.1177/0143034310382496
Townsend M, 2007, J APPL RES INTELLECT, V20, P265, DOI 10.1111/j.1468-3148.2006.00329.x
Williams GJ, 2003, INTERV SCH CLIN, V38, P205, DOI 10.1177/105345120303800402
Wolery M., 1994, TEACHER ED SPECIAL E, V17, P1, DOI 10.1177/088840649401700102
NR 58
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1360-3116
EI 1464-5173
J9 INT J INCLUSIVE EDUC
JI Int. J. Incl. Educ.
PD MAY 4
PY 2014
VL 18
IS 5
BP 500
EP 514
DI 10.1080/13603116.2013.789088
PG 15
WC Education & Educational Research
SC Education & Educational Research
GA AH0XL
UT WOS:000335844000005
ER
PT J
AU Kuzmanovic, B
Schilbach, L
Georgescu, AL
Kockler, H
Santos, NS
Shah, NJ
Bente, G
Fink, GR
Vogeley, K
AF Kuzmanovic, Bojana
Schilbach, Leonhard
Georgescu, Alexandra L.
Kockler, Hanna
Santos, Natacha S.
Shah, N. Jon
Bente, Gary
Fink, Gereon R.
Vogeley, Kai
TI Dissociating animacy processing in high-functioning autism: Neural
correlates of stimulus properties and subjective ratings
SO SOCIAL NEUROSCIENCE
LA English
DT Article
DE Animacy; High-functioning autism; Amygdala; dmPFC; Social cognition
ID ASPERGER-SYNDROME; SPECTRUM DISORDERS; SOCIAL COGNITION; PREFRONTAL
CORTEX; 1ST IMPRESSIONS; MENTAL STATES; MIND; BRAIN; ATTRIBUTION;
PERCEPTION
AB When movements indicate meaningful actions, even nonbiological objects induce the impression of having a mind or animacy. This basic social ability was investigated in adults with high-functioning autism (HFA, n=13, and matched controls, n=13) by systematically varying motion properties of simple geometric shapes. Critically, trial-by-trial variations of (1) motion complexity of stimuli, and of (2) participants' individual animacy ratings were separately correlated with neural activity to dissociate cognitive strategies relying more closely on stimulus analysis vs. subjective experience. Increasing motion complexity did not yield any significant group differences, and in both groups, it correlated with neural activity in regions involved in perceptual and evaluative processing, including the ventral medial prefrontal cortex (mPFC), superior temporal gyrus (STG) and posterior cingulate cortex (PCC). In contrast, although there were no significant behavioral differences between the groups, increasing animacy ratings correlated with neural activity in the insula, STG, amygdala, dorsal mPFC and PCC more strongly in controls than in HFA. These results indicate that in HFA the evaluation of stimulus properties cuing for animacy is intact, while increasing subjective ratings do not seem to be robustly related to social processing, including spontaneous mental state inferences and experience of salience.
C1 [Kuzmanovic, Bojana] Res Ctr Juelich, Inst Neurosci & Med Eth Neurosci INM 8, Julich, Germany.
[Kuzmanovic, Bojana; Schilbach, Leonhard; Georgescu, Alexandra L.; Kockler, Hanna; Santos, Natacha S.; Vogeley, Kai] Univ Hosp Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany.
[Shah, N. Jon] Res Ctr Juelich, Inst Neurosci & Med Med Imaging Phys INM 4, Julich, Germany.
[Bente, Gary] Univ Cologne, Dept Social Psychol & Media Psychol, D-50931 Cologne, Germany.
[Fink, Gereon R.; Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med Cognit Neurosci INM 3, Julich, Germany.
[Fink, Gereon R.] Univ Hosp Cologne, Dept Neurol, Cologne, Germany.
RP Kuzmanovic, B (reprint author), Forschungszentrum Julich, INM 8, D-52425 Julich, Germany.
EM b.kuzmanovic@fz-juelich.de
RI Fink, Gereon/E-1616-2012
OI Fink, Gereon/0000-0002-8230-1856
FU Federal Ministry of Education and Research, Germany [01GP0802]
FX This work was supported by the Federal Ministry of Education and
Research, Germany [01GP0802; KV].
CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
Bar M, 2006, P NATL ACAD SCI USA, V103, P449, DOI 10.1073/pnas.0507062103
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Beck A. T., 1987, BECK DEPRESSION INVE
Blake R, 2007, ANNU REV PSYCHOL, V58, P47, DOI 10.1146/annurev.psych.57.102904.190152
Buchel C, 1998, NEUROIMAGE, V8, P140, DOI 10.1006/nimg.1998.0351
Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
D'Argembeau A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00372
David N, 2010, J AUTISM DEV DISORD, V40, P1549, DOI 10.1007/s10803-010-1008-9
David N, 2011, AUTISM RES, V4, P383, DOI 10.1002/aur.210
Duvernoy H. M., 1999, HUMAN BRAIN SURFACE, V2nd
Eickhoff SB, 2007, NEUROIMAGE, V36, P511, DOI 10.1016/j.neuroimage.2007.03.060
Epley N., 2010, HDB SOCIAL PSYCHOL
Freeman JB, 2010, HUM BRAIN MAPP, V31, P150, DOI 10.1002/hbm.20852
Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x
Gobbini MI, 2007, J COGNITIVE NEUROSCI, V19, P1803, DOI 10.1162/jocn.2007.19.11.1803
Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040
Heberlein AS, 2004, P NATL ACAD SCI USA, V101, P7487, DOI 10.1073/pnas.0308220101
Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
Klin A, 2006, BRAIN COGNITION, V61, P40, DOI 10.1016/j.bandc.2005.12.016
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
Kuzmanovic B, 2011, RES AUTISM SPECT DIS, V5, P604, DOI 10.1016/j.rasd.2010.07.005
Kuzmanovic B, 2012, NEUROIMAGE, V60, P179, DOI 10.1016/j.neuroimage.2011.12.046
Lehnhardt FG, 2011, FORTSCHR NEUROL PSYC, V79, P290, DOI 10.1055/s-0031-1273233
LEHRL S, 1995, ACTA NEUROL SCAND, V91, P335
Lieberman M, 2010, HDB SOCIAL PSYCHOL, P143
Martin A, 2003, COGN NEUROPSYCHOL, V20, P575, DOI 10.1080/02643290342000005
Pessoa L, 2008, NAT REV NEUROSCI, V9, P148, DOI 10.1038/nrn2317
Phan KL, 2004, NEUROIMAGE, V21, P768, DOI 10.1016/j.neuroimage.2003.09.072
Redcay E., 2012, HUM BRAIN MAPP, V34, P2511, DOI [10.1002/hbm.22086, DOI 10.1002/HBM.22086]
Robinson JL, 2010, HUM BRAIN MAPP, V31, P173, DOI 10.1002/hbm.20854
Santos NS, 2008, CONSCIOUS COGN, V17, P425, DOI 10.1016/j.concog.2008.03.012
Santos NS, 2010, NEUROIMAGE, V53, P291, DOI 10.1016/j.neuroimage.2010.05.080
Satzger W, 2002, Z DIFFERENTIELLE DIA, V23, P159, DOI 10.1024//0170-1789.23.2.159
Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040
Schilbach L, 2012, AUTISM, V16, P151, DOI 10.1177/1362361311409258
Schilbach L, 2013, BEHAV BRAIN SCI, V36, P393, DOI 10.1017/S0140525X12000660
Schilbach L, 2008, CONSCIOUS COGN, V17, P457, DOI 10.1016/j.concog.2008.03.013
Schiller D, 2009, NAT NEUROSCI, V12, P508, DOI 10.1038/nn.2278
Schmidt K-H, 1992, WORTSCHATZTEST WST
Schultz J, 2005, NEURON, V45, P625, DOI 10.1016/j.neuron.2004.12.052
Schultz J, 2004, J COGNITIVE NEUROSCI, V16, P1695, DOI 10.1162/0898929042947874
Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208
Senju A, 2012, NEUROSCIENTIST, V18, P108, DOI 10.1177/1073858410397208
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Singer T, 2009, TRENDS COGN SCI, V13, P334, DOI 10.1016/j.tics.2009.05.001
Spengler S, 2010, BIOL PSYCHIAT, V68, P1148, DOI 10.1016/j.biopsych.2010.09.017
Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
Tavares P, 2008, CEREB CORTEX, V18, P1876, DOI 10.1093/cercor/bhm212
Tremoulet PD, 2000, PERCEPTION, V29, P943, DOI 10.1068/p3101
Wheatley T, 2007, PSYCHOL SCI, V18, P469, DOI 10.1111/j.1467-9280.2007.01923.x
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
Woodbury-Smith M, 2005, J AUTISM DEV DISORD, V35, P235, DOI 10.1007/s10803-005-2002-5
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
Zwickel J., 2010, SOCIAL COGNITIVE AFF, V6, P564
Zysset S, 2003, NEUROSCI LETT, V335, P183, DOI 10.1016/S0304-3940(02)01196-5
NR 64
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1747-0919
EI 1747-0927
J9 SOC NEUROSCI-UK
JI Soc. Neurosci.
PD MAY 4
PY 2014
VL 9
IS 3
BP 309
EP 325
DI 10.1080/17470919.2014.886618
PG 17
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AE5ZE
UT WOS:000334067000011
PM 24512520
ER
PT J
AU Beck, DE
Maranto, R
Lo, WJ
AF Beck, Dennis E.
Maranto, Robert
Lo, Wen-Juo
TI Determinants of Student and Parent Satisfaction at a Cyber Charter
School
SO JOURNAL OF EDUCATIONAL RESEARCH
LA English
DT Article
DE special education; parent satisfaction; cyber schools; student
satisfaction
ID COMPARING RESPONSE RATES; DOWN-SYNDROME; AUTISM; CHILDREN; EDUCATION;
METAANALYSIS; ADOLESCENCE; SUPPORT; HEALTH; LIFE
AB Research indicates that in traditional public schools the subjective well-being of students and parents varies by gender, race, and special education status. Prior studies suggest that general education students are more satisfied with their schooling than special education students, that female students have greater satisfaction with their schooling than male students, and that Caucasian and Latino students report greater school satisfaction than African American students. No prior research has studied parental and student subjective well-being in a cyber environment. The authors investigate parental and student subjective well-being in a cyber charter school, using a student (n = 269; 53.7% response rate) and parent (n = 232; 48.7% response rate) survey. They find statistically significant differences in subjective well-being across demographic groups of students, and also significantly higher satisfaction among special education students in the cyber school environment. Implications are discussed.
C1 [Beck, Dennis E.] Univ Arkansas, Fayetteville, AR 72701 USA.
[Maranto, Robert] Univ Arkansas, Dept Educ Reform, Fayetteville, AR 72701 USA.
[Lo, Wen-Juo] Univ Arkansas, Educ Stat & Res Methodol ESRM, Fayetteville, AR 72701 USA.
RP Beck, DE (reprint author), Univ Arkansas, CIED, 102 PEAH, Fayetteville, AR 72701 USA.
EM debeck@uark.edu
CR Arber S., 2001, RES SOCIAL LIFE, P58
Bailey D., 2003, FAMILIES 1 EXPERIENC
Baker J. A., 1999, ELEMENTARY SCH J, V85, P69
Bitterman A, 2008, J AUTISM DEV DISORD, V38, P1509, DOI 10.1007/s10803-007-0531-9
Buck J. S., 2010, ACTING WHITE
Burns J., 2001, WESTMINISTER STUDIES, V24, P155
Clark M. A., 2006, ASCA SCH COUNSELOR, V43, P20
Costello A, 2005, PRACTICAL ASSESSMENT, V10, P7
CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297
Culp K. M., 2005, Journal of Educational Computing Research, V32, DOI 10.2190/7W71-QVT2-PAP2-UDX7
Descry C., 2001, UNSCREWED ED ANNIE
Dillman D. A., 2009, INTERNET MAIL MIXED
DING C, 2007, STUDIES ED EVALUATIO, V0033
Eamons N. K., 2002, J YOUTH ADOLESCENCE, V31, P231
ECCLES JS, 1993, AM PSYCHOL, V48, P90, DOI 10.1037//0003-066X.48.2.90
Epstein J. L, 1981, QUALITY SCH LIFE
EPSTEIN JL, 1976, AM EDUC RES J, V13, P15, DOI 10.3102/00028312013001015
Fabrigar LR, 1999, PSYCHOL METHODS, V4, P272, DOI 10.1037//1082-989X.4.3.272
Floyd FJ, 1995, PSYCHOL ASSESSMENT, V7, P286, DOI 10.1037//1040-3590.7.3.286
Friedman B. A., 2006, J EDUC ADMIN, V44, P471, DOI 10.1108/09578230610683769
Gibbons S, 2011, ECON EDUC REV, V30, P312, DOI 10.1016/j.econedurev.2010.11.001
Glass G. V., 2008, FERTILIZERS PILLS MA
Gunn C, 2003, J ASYNCHRONOUS LEARN, V7, P14
Henderson A. T., 2007, BAKE SALE
Hess F, 2001, TEACH COLL REC, V103, P1102, DOI 10.1111/0161-4681.00144
HORN JL, 1965, PSYCHOMETRIKA, V30, P179, DOI 10.1007/BF02289447
Huebner E., 1994, PSYCHOL ASSESSMENT, V6, P149, DOI [10.1037/1040-3590.6.2.149, DOI 10.1037/1040-3590.6.2.149]
Huebner E. S., 2000, SCHOOL PSYCHOL INT, V21, P218
Johnson J., 2002, ITS YOUR OWN CHILD R
Kafer K., 2004, GIRL POWER WHY GIRLS
Kangas M., 2008, LEARNING ENV RES, V13, P205
Karatzias A, 2001, J YOUTH ADOLESCENCE, V30, P465, DOI 10.1023/A:1010497216920
Karazias A., 2002, ED PSYCHOL, V22, P33, DOI DOI 10.1080/01443410120101233
Kasari C, 1999, J AUTISM DEV DISORD, V29, P297, DOI 10.1023/A:1022159302571
Laws G, 2001, EDUC RES, V43, P209, DOI 10.1080/00131880110051173
Levine P., 2004, SPECIAL ED ELEMENTAR
Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
Manfreda KL, 2008, INT J MARKET RES, V50, P79
Maranto Robert, 2012, PRESIDENT OBAMA ED R
Montes G, 2009, PEDIATRICS, V124, P407
Natvig Gerd Karin, 2003, Int J Nurs Pract, V9, P166, DOI 10.1046/j.1440-172X.2003.00419.x
Nickerson AB, 2004, SOC INDIC RES, V66, P35, DOI 10.1023/B:SOCI.0000007496.42095.2c
O'Brien T., 2010, UNIQUE SCH SERVING U, P16
OKUN MA, 1990, SOC INDIC RES, V22, P419, DOI 10.1007/BF00303835
Ong-Dean Colin, 2009, DISTINGUISHING DISAB
Ravitch D., 2010, DEATH LIFE GREAT AM
Reise SP, 2000, PSYCHOL ASSESSMENT, V12, P287, DOI 10.1037//1040-3590.12.3.287
Renty J, 2006, CHILD CARE HLTH DEV, V32, P371, DOI 10.1111/j.1365-2214.2006.00584.x
Samdal O, 1998, HEALTH EDUC RES, V13, P383, DOI 10.1093/her/13.3.383
Shih TH, 2008, FIELD METHOD, V20, P249, DOI 10.1177/1525822X08317085
Siklos S, 2006, J AUTISM DEV DISORD, V36, P921, DOI 10.1007/s10803-006-0129-7
Sitzia J, 1998, INT J QUAL HEALTH C, V10, P311, DOI 10.1093/intqhc/10.4.311
Southwest Educational Development Laboratory, 2004, READ SCH FAM COMM CO
Spann S. J., 2003, FOCUS AUTISM OTHER D, V18, P228, DOI DOI 10.1177/10883576030180040401
Tabachnick B., 2007, USING MULTIVARIATE S, V5th
Valdes G., 1996, CON RESPETO
Valle JW, 2009, PALG STUD URBAN EDUC, P1, DOI 10.1057/9780230619739
Verkuyten M, 2002, SOC INDIC RES, V59, P203, DOI 10.1023/A:1016279602893
Yancey G., 2011, COMPROMISING SCHOLAR
NR 59
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0022-0671
EI 1940-0675
J9 J EDUC RES
JI J. Educ. Res.
PD MAY 4
PY 2014
VL 107
IS 3
BP 209
EP 216
DI 10.1080/00220671.2013.807494
PG 8
WC Education & Educational Research
SC Education & Educational Research
GA AE3KI
UT WOS:000333875000005
ER
PT J
AU Lamport, D
Turner, LA
AF Lamport, Dustin
Turner, Lisa A.
TI Romantic Attachment, Empathy, and the Broader Autism Phenotype among
College Students
SO JOURNAL OF GENETIC PSYCHOLOGY
LA English
DT Article
DE broader autism phenotype; empathy; romantic attachment
ID SPECTRUM QUOTIENT AQ; ADULT ATTACHMENT; RELATIONSHIP SATISFACTION;
FUNCTIONING AUTISM; NONCLINICAL SAMPLE; GENERAL-POPULATION; PATTERNS;
CHILDREN; TRAITS; STYLES
AB Recent research suggests that mild autistic-like characteristics can be measured among relatives of individuals with autism and in the general population. These characteristics have been referred to as the broader autism phenotype (BAP), and include pragmatic language difficulties, aloofness, and rigidity. Evidence is growing to suggest that individuals with BAP encounter difficulties in their social interactions. Recent work demonstrates that college students scoring high on the BAP report more loneliness (Jobe & Williams White, 2007) and more interpersonal problems (Wainer, Ingersoll, & Hopwood, 2012). Because intimate relationships are important in development and are very salient in emerging adulthood, the authors examined the relation of the BAP to romantic attachment and empathy among young adults. Higher BAP scores were associated with lower empathy and higher attachment anxiety and avoidance. Specifically, pragmatic language difficulties were related to higher rates of avoidant attachment and this relationship was mediated by empathy. In contrast, pragmatic language deficits were directly related to anxious attachment.
C1 [Lamport, Dustin] Univ S Alabama, Mobile, AL 36688 USA.
[Turner, Lisa A.] Univ S Alabama, Dept Psychol, Mobile, AL 36688 USA.
RP Turner, LA (reprint author), Univ S Alabama, Dept Psychol, Mobile, AL 36688 USA.
EM laturner@southalabama.edu
CR AINSWORTH MDS, 1979, AM PSYCHOL, V34, P932, DOI 10.1037//0003-066X.34.10.932
Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Bartholomew K., 1991, J PERS SOC PSYCHOL, V61, P224
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
BOWLBY J, 1977, BRIT J PSYCHIAT, V130, P201, DOI 10.1192/bjp.130.3.201
Brennan K. A., 1998, ATTACHMENT THEORY CL, P46
Britton PC, 2005, J SOC PSYCHOL, V145, P519, DOI 10.3200/SOCP.145.5.519-530
Centers for Disease Control, 2014, AUTISM
Chen FS, 2011, J AUTISM DEV DISORD, V41, P1131, DOI 10.1007/s10803-010-1136-2
Clark TF, 2008, EMOTION, V8, P803, DOI 10.1037/a0014124
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103
Fombonne E, 1997, J CHILD PSYCHOL PSYC, V38, P667, DOI 10.1111/j.1469-7610.1997.tb01694.x
Fraley RC, 2002, PERS SOC PSYCHOL REV, V6, P123, DOI 10.1207/S15327957PSPR0602_03
Fraley RC, 2000, J PERS SOC PSYCHOL, V78, P350, DOI 10.1037/0022-3514.78.2.350
Hayes AF, 2009, COMMUN MONOGR, V76, P408, DOI 10.1080/03637750903310360
HAZAN C, 1987, J PERS SOC PSYCHOL, V52, P511, DOI 10.1037//0022-3514.52.3.511
Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
Ingersoll B, 2010, J AUTISM DEV DISORD, V40, P590, DOI 10.1007/s10803-009-0907-0
Ingersoll B, 2011, J AUTISM DEV DISORD, V41, P1646, DOI 10.1007/s10803-011-1192-2
Ingersoll B, 2011, AUTISM RES, V4, P143, DOI 10.1002/aur.170
Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
Joireman JA, 2002, N AM J PSYCHOL, V4, P63
KIRKPATRICK LA, 1994, PERS RELATIONSHIP, V1, P123, DOI 10.1111/j.1475-6811.1994.tb00058.x
Klohnen EC, 1998, J PERS SOC PSYCHOL, V74, P211, DOI 10.1037/0022-3514.74.1.211
Lind SE, 2010, J AUTISM DEV DISORD, V40, P479, DOI 10.1007/s10803-009-0889-y
Pollmann MMH, 2010, J AUTISM DEV DISORD, V40, P470, DOI 10.1007/s10803-009-0888-z
Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
SIMPSON JA, 1990, J PERS SOC PSYCHOL, V59, P971, DOI 10.1037/0022-3514.59.5.971
Stackert RA, 2003, PERS INDIV DIFFER, V34, P1419, DOI 10.1016/S0191-8869(02)00124-1
Wainer AL, 2011, J PSYCHOPATHOL BEHAV, V33, P459, DOI 10.1007/s10862-011-9259-0
Wakabayashi A, 2006, PERS INDIV DIFFER, V41, P929, DOI 10.1016/j.paid.2006.03.017
Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
Wei MF, 2011, J PERS, V79, P191, DOI 10.1111/j.1467-6494.2010.00677.x
Wong C, 2012, J AUTISM DEV DISORD, V42, P2152, DOI 10.1007/s10803-012-1467-2
NR 38
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0022-1325
EI 1940-0896
J9 J GENET PSYCHOL
JI J. Genet. Psychol.
PD MAY 4
PY 2014
VL 175
IS 3
BP 202
EP 213
DI 10.1080/00221325.2013.856838
PG 12
WC Psychology, Developmental; Psychology; Psychology, Multidisciplinary
SC Psychology
GA AG3EG
UT WOS:000335298000002
PM 25175527
ER
PT J
AU Michel, C
Hoehl, S
Striano, T
AF Michel, Christine
Hoehl, Stefanie
Striano, Tricia
TI The influence of familiarity on explicit eye gaze judgement in
preschoolers
SO EUROPEAN JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE Familiarity; Preschoolers; Explicit eye gaze judgement
ID AUTISM SPECTRUM DISORDER; 6-MONTH-OLD INFANTS; VISUAL-ATTENTION;
YOUNG-CHILDREN; RECOGNITION; FACE; MOTHERS; STRANGERS; LOOKING; AGE
AB The current study explores the influence of familiarity on explicit eye gaze judgement in preschoolers. We introduce reaction times for touches as a new measure for children studies. Children aged four-six years saw either their caregiver's face or a stranger's face looking at an object or away from it. Children were asked to touch the face that was looking at the object and reaction times to correct touches were measured. Children reacted faster to strangers' faces than to their caregivers' faces. This may indicate that preschoolers used the face of a stranger more effectively as a source of information about the environment and for this reason detected the eye gaze-object relationship faster. In addition, children's reactions were faster in a nonsocial shape-matching task than in the social eye gaze-judgement task. The applied paradigm is appropriate to further investigate the development and influencing factors of explicit eye gaze judgements in preschoolers.
C1 [Michel, Christine; Hoehl, Stefanie] Heidelberg Univ, Inst Psychol, D-69117 Heidelberg, Germany.
[Striano, Tricia] CUNY Hunter Coll, New York, NY 10021 USA.
[Striano, Tricia] Inst Educ Hlth & Res, Milton, MA USA.
RP Michel, C (reprint author), Heidelberg Univ, Inst Psychol, Hauptstr 47-51, D-69117 Heidelberg, Germany.
EM christine.michel@psychologie.uni-heidelberg.de
RI Hoehl, Stefanie/N-2452-2014
OI Hoehl, Stefanie/0000-0003-0472-0374
CR Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820
Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
Deaner RO, 2007, BIOL LETT-UK, V3, P64, DOI 10.1098/rsbl.2006.0564
deHaan M, 1997, CHILD DEV, V68, P187, DOI 10.2307/1131845
de Haan M, 1999, DEV PSYCHOL, V35, P1113, DOI 10.1037/0012-1649.35.4.1113
Devouche E, 2004, INFANT CHILD DEV, V13, P35, DOI 10.1002/icd.334
Doherty MJ, 2006, INFANT CHILD DEV, V15, P179, DOI 10.1002/icd.434
Doherty MJ, 2009, J EXP CHILD PSYCHOL, V104, P296, DOI 10.1016/j.jecp.2009.06.004
Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
Gredeback G, 2010, DEVELOPMENTAL SCI, V13, P839, DOI 10.1111/j.1467-7687.2009.00945.x
Herba CM, 2006, J CHILD PSYCHOL PSYC, V47, P1098, DOI 10.1111/j.1469-7610.2006.01652.x
Hoehl S, 2012, DEV COGN NEUROS-NETH, V2, P81, DOI 10.1016/j.dcn.2011.07.015
Hoehl S, 2009, CHILD DEV, V80, P968, DOI 10.1111/j.1467-8624.2009.01311.x
MASANGKA.ZS, 1974, CHILD DEV, V45, P357, DOI 10.2307/1127956
Natu V, 2011, BRIT J PSYCHOL, V102, P726, DOI 10.1111/j.2044-8295.2011.02053.x
Riby DM, 2009, RES AUTISM SPECT DIS, V3, P723, DOI 10.1016/j.rasd.2009.02.001
Ristic J, 2002, PSYCHON B REV, V9, P507, DOI 10.3758/BF03196306
Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x
Snyder KA, 2010, INFANCY, V15, P270, DOI 10.1111/j.1532-7078.2009.00015.x
Striano T, 2005, COGNITION EMOTION, V19, P781, DOI 10.1080/02699930541000002
Szekely E, 2011, J CHILD PSYCHOL PSYC, V52, P1279, DOI 10.1111/j.1469-7610.2011.02423.x
Walden TA, 2005, INT J BEHAV DEV, V29, P356, DOI 10.1080/01650250500166824
Wilson R, 2007, J AUTISM DEV DISORD, V37, P314, DOI 10.1007/s10803-006-0169-z
NR 23
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1740-5629
EI 1740-5610
J9 EUR J DEV PSYCHOL
JI Eur. J. Dev. Psychol.
PD MAY 4
PY 2014
VL 11
IS 3
BP 344
EP 355
DI 10.1080/17405629.2013.832670
PG 12
WC Psychology, Developmental
SC Psychology
GA AE4WW
UT WOS:000333988000006
ER
PT J
AU Prevost, M
Carrier, ME
Chowne, G
Zelkowitz, P
Joseph, L
Gold, I
AF Prevost, Marie
Carrier, Marie-Eve
Chowne, Gabrielle
Zelkowitz, Phyllis
Joseph, Lawrence
Gold, Ian
TI The Reading the Mind in the Eyes test: validation of a French version
and exploration of cultural variations in a multi-ethnic city
SO COGNITIVE NEUROPSYCHIATRY
LA English
DT Article
DE theory of mind; empathy; translation; Francophone; culture; language
ID UNAFFECTED 1ST-DEGREE RELATIVES; HIGH-FUNCTIONING AUTISM;
ASPERGER-SYNDROME; SCHIZOPHRENIA-PATIENTS; SOCIAL COGNITION; IMPAIRED
THEORY; POPULATION; EMPATHY; ADULTS; FACE
AB IntroductionThe first aim of our study was to validate the French version of the Reading the Mind in the Eyes test, a theory of mind test. The second aim was to test whether cultural differences modulate performance on this test.MethodsA total of 109 participants completed the original English version and 97 participants completed the French version. Another group of 30 participants completed the French version twice, one week apart.ResultsWe report a similar overall distribution of scores in both versions and no differences in the mean scores between them. However, 2 items in the French version did not collect a majority of responses, which differed from the results of the English version. Test-retest showed good stability of the French version. As expected, participants who do not speak French or English at home, and those born in Asia, performed worse than North American participants, and those who speak English or French at home.ConclusionsWe report a French version with acceptable validity and good stability. The cultural differences observed support the idea that Asian culture does not use theory of mind to explain people's behaviours as much as North American people do.
C1 [Prevost, Marie; Chowne, Gabrielle; Gold, Ian] McGill Univ, Dept Philosophy, Montreal, PQ H3A 2T7, Canada.
[Prevost, Marie; Chowne, Gabrielle; Gold, Ian] McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T7, Canada.
[Carrier, Marie-Eve; Zelkowitz, Phyllis] McGill Univ, Jewish Gen Hosp, Dept Psychiat, Montreal, PQ H3T 1E2, Canada.
[Carrier, Marie-Eve; Zelkowitz, Phyllis] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada.
[Joseph, Lawrence] McGill Univ, Royal Victoria Hosp, Ctr Hlth, Div Clin Epidemiol, Montreal, PQ H3A 1A1, Canada.
RP Prevost, M (reprint author), McGill Univ, Dept Philosophy, Leacock Bldg,Room 908,855 Sherbrooke West, Montreal, PQ H3A 2T7, Canada.
EM marie.prevost@mail.mcgill.ca
FU CIHR Team in Perinatal Mental Health
FX This work was supported by the CIHR Team in Perinatal Mental Health.
CR Adams RB, 2010, J COGNITIVE NEUROSCI, V22, P97, DOI 10.1162/jocn.2009.21187
Ahmed FS, 2011, J AUTISM DEV DISORD, V41, P667, DOI 10.1007/s10803-010-1087-7
Alaerts K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020989
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
Boisseau E., 2010, THESIS U QUEBEC MONT
Carroll JM, 2006, J AUTISM DEV DISORD, V36, P949, DOI 10.1007/s10803-006-0127-9
Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
Chatel-Goldman J, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00107
Choi I, 2003, J PERS SOC PSYCHOL, V84, P46, DOI 10.1037/0022-3514.84.1.46
Cook CM, 2010, PERS INDIV DIFFER, V49, P712, DOI 10.1016/j.paid.2010.06.010
de Achaval D, 2010, NEUROPSYCHOLOGIA, V48, P1209, DOI 10.1016/j.neuropsychologia.2009.12.019
Dehning S, 2012, BMC MED EDUC, V12, DOI 10.1186/1472-6920-12-34
Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Hallerbäck Maria Unenge, 2009, Cogn Neuropsychiatry, V14, P127, DOI 10.1080/13546800902901518
Harkness KL, 2010, COGNITION EMOTION, V24, P497, DOI 10.1080/02699930902750249
Hirao K, 2008, SCHIZOPHR RES, V105, P165, DOI 10.1016/j.schres.2008.07.021
Irani F, 2006, SCHIZOPHR RES, V88, P151, DOI 10.1016/j.schres.2006.07.016
Johnston L, 2008, AUST J PSYCHOL, V60, P135, DOI 10.1080/00049530701449521
Kelemen O, 2004, ACTA PSYCHIAT SCAND, V110, P146, DOI 10.1111/j.1600-0047.2004.00357.x
Kelemen O, 2005, NEUROPSYCHOLOGY, V19, P494, DOI 10.1037/0894-4105.19.4.494
Kenyon M, 2012, INT J EAT DISORDER, V45, P377, DOI 10.1002/eat.20967
Kettle JWL, 2008, SCHIZOPHR RES, V99, P96, DOI 10.1016/j.schres.2007.11.011
Kucera H., 1967, COMPUTATIONAL ANAL P
Kunihira Y, 2006, J AUTISM DEV DISORD, V36, P553, DOI 10.1007/s10803-006-0094-1
Lillard A, 1998, PSYCHOL BULL, V123, P3, DOI 10.1037/0033-2909.123.1.3
Lillard A, 1999, CURR DIR PSYCHOL SCI, V8, P57, DOI 10.1111/1467-8721.00014
Mason MF, 2010, SOC COGN AFFECT NEUR, V5, P292, DOI 10.1093/scan/nsq034
Masuda T, 2008, J PERS SOC PSYCHOL, V94, P365, DOI 10.1037/0022-3514.94.3.365
Masuda T, 2001, J PERS SOC PSYCHOL, V81, P922, DOI 10.1037//0022-3514.81.5.922
McGlade N, 2008, BRIT J PSYCHIAT, V193, P77, DOI 10.1192/bjp.bp.107.044198
MORRIS MW, 1994, J PERS SOC PSYCHOL, V67, P949, DOI 10.1037/0022-3514.67.6.949
Murphy David, 2006, Cogn Neuropsychiatry, V11, P99, DOI 10.1080/13546800444000182
New B, 2001, ANN PSYCHOL, V101, P447
PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
Rule NO, 2010, J PERS SOC PSYCHOL, V98, P1, DOI 10.1037/a0017673
Russell TA, 2000, AM J PSYCHIAT, V157, P2040, DOI 10.1176/appi.ajp.157.12.2040
Serafin M, 2004, GIORNALE ITALIANO PS, V4, P839
Shahaeian A, 2011, DEV PSYCHOL, V47, P1239, DOI 10.1037/a0023899
Smeets T, 2009, HORM BEHAV, V55, P507, DOI 10.1016/j.yhbeh.2009.01.011
Stanford AD, 2011, SCHIZOPHR RES, V131, P11, DOI 10.1016/j.schres.2011.06.005
Valla JM, 2010, AUTISM RES, V3, P174, DOI 10.1002/aur.143
Voracek M, 2006, PERS INDIV DIFFER, V41, P1481, DOI 10.1016/j.paid.2006.06.009
Yildirim EA, 2011, TURK PSIKIYATR DERG, V22, P177, DOI 10.5080/u6500
NR 45
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1354-6805
EI 1464-0619
J9 COGN NEUROPSYCHIATRY
JI Cogn. Neuropsychiatry
PD MAY 4
PY 2014
VL 19
IS 3
BP 189
EP 204
DI 10.1080/13546805.2013.823859
PG 16
WC Psychiatry
SC Psychiatry
GA AA3YS
UT WOS:000331031700001
PM 23937473
ER
PT J
AU Bellebaum, C
Brodmann, K
Thoma, P
AF Bellebaum, Christian
Brodmann, Katja
Thoma, Patrizia
TI Active and observational reward learning in adults with autism spectrum
disorder: relationship with empathy in an atypical sample
SO COGNITIVE NEUROPSYCHIATRY
LA English
DT Article
DE autism; empathy; reward; FRN; observational learning
ID MAJOR DEPRESSIVE DISORDER; EVENT-RELATED POTENTIALS; ERROR-RELATED
NEGATIVITY; HIGH-FUNCTIONING AUTISM; TIME-ESTIMATION TASK; NEURAL
SYSTEM; DOPAMINERGIC INNERVATION; PSYCHIATRIC-DISORDERS;
PERSPECTIVE-TAKING; BRAIN POTENTIALS
AB IntroductionAutism spectrum disorders (ASDs) are characterised by disturbances in social behaviour. A prevailing hypothesis suggests that these problems are related to deficits in assigning rewarding value to social stimuli. The present study aimed to examine monetary reward processing in adults with ASDs by means of event-related potentials (ERPs).MethodsTen individuals with mild ASDs (Asperger's syndrome and high-functioning autism) and 12 healthy control subjects performed an active and an observational probabilistic reward-learning task.ResultsBoth groups showed similar overall learning performance. With respect to reward processing, subjects with ASDs exhibited a general reduction in feedback-related negativity (FRN) amplitude, irrespective of feedback valence and type of learning (active or observational). Individuals with ASDs showed lower scores for cognitive empathy, while affective empathy did not differ between groups. Correlation analyses revealed that higher empathy (both cognitive and affective) negatively affected performance in observational learning in controls and in active learning in ASDs (only cognitive empathy). No relationships were seen between empathy and ERPs.ConclusionsReduced FRN amplitudes are discussed in terms of a deficit in fast reward processing in ASDs, which may indicate altered reward system functioning.
C1 [Bellebaum, Christian; Brodmann, Katja; Thoma, Patrizia] Ruhr Univ Bochum, Fac Psychol, Dept Neuropsychol, Inst Cognit Neurosci, Bochum, Germany.
RP Thoma, P (reprint author), Ruhr Univ Bochum, Fac Psychol, Dept Neuropsychol, Inst Cognit Neurosci, Bochum, Germany.
EM Patrizia.Thoma@rub.de
FU Ministry of Innovation, Science and Research of the federal state of
Nordrhein-Westfalen, Germany (Ministerium fur Innovation, Wissenschaft
und Forschung des Landes Nordrhein-Westfalen [334-4]; DFG (German
Research Foundation)
FX We thank the Ministry of Innovation, Science and Research of the federal
state of Nordrhein-Westfalen, Germany (Ministerium fur Innovation,
Wissenschaft und Forschung des Landes Nordrhein-Westfalen [grant number
334-4]) for supporting this research. This study was also partly funded
by a scheme to reward the successful first attainment of DFG (German
Research Foundation) projects ("Novice Premium''), awarded to P. T. by
the Ruhr University Bochum.
CR Aron AR, 2004, J NEUROPHYSIOL, V92, P1144, DOI 10.1152/jn.01209.2003
Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
BECK AT, 1988, J CONSULT CLIN PSYCH, V56, P893, DOI 10.1037/0022-006X.56.6.893
Beck A.T., 1995, BECK DEPRESSIONS INV
Bellebaum C, 2010, CEREB CORTEX, V20, P2874, DOI 10.1093/cercor/bhq038
Bellebaum C, 2012, BEHAV BRAIN RES, V227, P241, DOI 10.1016/j.bbr.2011.10.042
BERGER B, 1991, TRENDS NEUROSCI, V14, P21, DOI 10.1016/0166-2236(91)90179-X
BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820
Chiu PH, 2007, AM J PSYCHIAT, V164, P608, DOI 10.1176/appi.ajp.164.4.608
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
DEHAENE S, 1994, PSYCHOL SCI, V5, P303, DOI 10.1111/j.1467-9280.1994.tb00630.x
Delgado MR, 2003, COGN AFFECT BEHAV NE, V3, P27, DOI 10.3758/CABN.3.1.27
Dichter G. S., 2010, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
Dilling H, 2000, INT KLASSIFIKATION P
Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
Falkenstein M., 1990, PSYCHOPHYSIOLOGICAL, P192
Ferdinand NK, 2012, J NEUROSCI, V32, P12087, DOI 10.1523/JNEUROSCI.1410-12.2012
Fukushima H, 2009, SOC NEUROSCI-UK, V4, P261, DOI 10.1080/17470910802625009
Fukushima H, 2006, SOC COGN AFFECT NEUR, V1, P149, DOI 10.1093/scan/nsl020
GEHRING WJ, 1993, PSYCHOL SCI, V4, P385, DOI 10.1111/j.1467-9280.1993.tb00586.x
Gehring WJ, 2002, SCIENCE, V295, P2279, DOI 10.1126/science.1066893
Georgiadi E, 2011, PSYCHOPHYSIOLOGY, V48, P1192, DOI 10.1111/j.1469-8986.2011.01198.x
Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348
Groen Y, 2008, CLIN NEUROPHYSIOL, V119, P2476, DOI 10.1016/j.clinph.2008.08.004
Haber SN, 1997, CRIT REV NEUROBIOL, V11, P323
Holmes AJ, 2008, ARCH GEN PSYCHIAT, V65, P179, DOI 10.1001/archgenpsychiatry.2007.19
Holmes AJ, 2010, COGN AFFECT BEHAV NE, V10, P119, DOI [10.3758/CABN.10.1.119, 10.3158/CABN.10.1.119]
Holroyd CB, 2007, PSYCHOPHYSIOLOGY, V44, P913, DOI 10.1111/j.1469-8986.2007.00561.x
Holroyd CB, 2009, COGN AFFECT BEHAV NE, V9, P59, DOI 10.3758/CABN.9.1.59
Holroyd CB, 2008, PSYCHOPHYSIOLOGY, V45, P688, DOI 10.1111/j.1469-8986.2008.00668.x
Holroyd CB, 2002, PSYCHOL REV, V109, P679, DOI 10.1037//0033-295X.109.4.679
Jocham G, 2009, NEUROSCI BIOBEHAV R, V33, P48, DOI 10.1016/j.neubiorev.2008.08.011
Kampe KKW, 2001, NATURE, V413, P589, DOI 10.1038/35098149
Kang SK, 2010, J EXP SOC PSYCHOL, V46, P229, DOI 10.1016/j.jesp.2009.09.012
Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
Koban L, 2012, COGN AFFECT BEHAV NE, V12, P460, DOI 10.3758/s13415-012-0091-0
Koban L, 2010, SOC NEUROSCI-UK, V5, P360, DOI 10.1080/17470911003651547
Kobza S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050250
Kobza S, 2011, BEHAV BRAIN RES, V225, P396, DOI 10.1016/j.bbr.2011.07.059
Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1
Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
LAINHART JE, 1994, J AUTISM DEV DISORD, V24, P587, DOI 10.1007/BF02172140
Lamm C, 2007, J COGNITIVE NEUROSCI, V19, P42, DOI 10.1162/jocn.2007.19.1.42
Larson MJ, 2010, PSYCHOPHYSIOLOGY, V47, P415, DOI 10.1111/j.1469-8986.2009.00949.x
Larson MJ, 2011, PSYCHIAT RES, V187, P198, DOI 10.1016/j.psychres.2010.11.006
Lee TW, 1999, NEURAL COMPUT, V11, P417, DOI 10.1162/089976699300016719
Lehrl S., 1977, MEHRFACHWAHL WORTSCH
Ma QG, 2011, NEUROIMAGE, V54, P2472, DOI 10.1016/j.neuroimage.2010.10.045
Mies GW, 2011, PSYCHOL MED, V41, P2515, DOI 10.1017/S0033291711000778
Miltner WHR, 1997, J COGNITIVE NEUROSCI, V9, P788, DOI 10.1162/jocn.1997.9.6.788
Mukaddes NM, 2010, WORLD J BIOL PSYCHIA, V11, P964, DOI 10.3109/15622975.2010.507785
MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
Newman-Norlund RD, 2009, SOC COGN AFFECT NEUR, V4, P10, DOI 10.1093/scan/nsn028
Noterdaeme M, 2010, EUR CHILD ADOLES PSY, V19, P475, DOI 10.1007/s00787-009-0057-0
O'Doherty J, 2004, SCIENCE, V304, P452, DOI 10.1126/science.1094285
Oliveira FTP, 2007, J COGNITIVE NEUROSCI, V19, P1994, DOI 10.1162/jocn.2007.19.12.1994
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Paulus C., 2007, SAARBRUCKER PERSONAL
Rademacher L, 2010, NEUROIMAGE, V49, P3276, DOI 10.1016/j.neuroimage.2009.10.089
Ruchsow M, 2006, J PSYCHIAT RES, V40, P37, DOI 10.1016/j.jpsychires.2005.02.002
Ruchsow M, 2004, PSYCHOPHYSIOLOGY, V41, P833, DOI 10.1111/j.1469-8986.2004.00237.x
Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975
Santesso DL, 2009, PSYCHOPHYSIOLOGY, V46, P143, DOI 10.1111/j.1469-8986.2008.00714.x
Santesso DL, 2008, NEUROREPORT, V19, P1045, DOI 10.1097/WNR.0b013e3283036e73
Schmitz N, 2008, BRIT J PSYCHIAT, V192, P19, DOI 10.1192/bjp.bp.107.036921
Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
Schultz W, 1997, SCIENCE, V275, P1593, DOI 10.1126/science.275.5306.1593
Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
Shamay-Tsoory SG, 2007, NEUROPSYCHOLOGIA, V45, P3054, DOI 10.1016/j.neuropsychologia.2007.05.021
Shane MS, 2009, SOC COGN AFFECT NEUR, V4, P111, DOI 10.1093/scan/nsn043
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
Solomon M, 2011, AUTISM RES, V4, P109, DOI 10.1002/aur.177
Spreckelmeyer KN, 2009, SOC COGN AFFECT NEUR, V4, P158, DOI 10.1093/scan/nsn051
Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015
TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
Thoma P, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00135
WILLIAMS SM, 1993, CEREB CORTEX, V3, P199, DOI 10.1093/cercor/3.3.199
Winston JS, 2007, NEUROPSYCHOLOGIA, V45, P195, DOI 10.1016/j.neuropsychologia.2006.05.009
Yamada M, 2011, EMOTION, V11, P1336, DOI 10.1037/a0023854
Yeung N, 2005, CEREB CORTEX, V15, P535, DOI 10.1093/cercor/bhh153
NR 87
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1354-6805
EI 1464-0619
J9 COGN NEUROPSYCHIATRY
JI Cogn. Neuropsychiatry
PD MAY 4
PY 2014
VL 19
IS 3
BP 205
EP 225
DI 10.1080/13546805.2013.823860
PG 21
WC Psychiatry
SC Psychiatry
GA AA3YS
UT WOS:000331031700002
PM 23998722
ER
PT J
AU Ludlow, AK
Heaton, P
Hill, E
Franklin, A
AF Ludlow, Amanda K.
Heaton, Pamela
Hill, Elisabeth
Franklin, Anna
TI Color obsessions and phobias in autism spectrum disorders: The case of
JG
SO NEUROCASE
LA English
DT Article
DE Autism Spectrum Disorders; Color; Obsessions; Phobias
ID CHILDREN; DISCRIMINATION; ABNORMALITIES
AB The current study is the first investigation of color obsessions' and phobias' in ASD. We investigate the color perception and cognition of J.G., a boy with ASD who has a strong obsession with blue, and a strong phobia of other colors. J.G.'s performance on a series of color tasks (color-entity association; chromatic discrimination; color classification) is compared to 13 children with and without autism who do not have color obsessions or phobias. The findings lead to the formalization of two hypotheses: (i) color obsessions and phobias in individuals with ASD are related to an unusually strong ability to associate colors with entities; (ii) color obsessions are related to hyposensitivity, and color phobias to hypersensitivity, in the affected regions of color space.
C1 [Ludlow, Amanda K.] Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
[Heaton, Pamela; Hill, Elisabeth] Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England.
[Franklin, Anna] Univ Sussex, Sch Psychol, Brighton, E Sussex, England.
RP Ludlow, AK (reprint author), Univ Birmingham, Birmingham B15 2TT, W Midlands, England.
EM a.k.ludlow@bham.ac.uk
FU EU [12984]; FRSF grant from the University of Surrey
FX We would like to thank all the children for taking part in the study and
also their parents and teachers for their co-operation in our research.
This work was supported by EU grant (12984) Stages in the Evolution and
Development of Sign Use (SEDSU), and a FRSF grant from the University of
Surrey to AF.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 1980, DIAGN STAT MAN MENT
Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
Davies I, 2002, BRIT J DEV PSYCHOL, V20, P185, DOI 10.1348/026151002166406
Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749
Dunn W., 1999, SENSORY PROFILE
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Fletcher R., 1998, CITY U COLOUR VISION
Franklin A, 2008, J AUTISM DEV DISORD, V38, P1837, DOI 10.1007/s10803-008-0574-6
Franklin A, 2010, DEVELOPMENTAL SCI, V13, P188, DOI 10.1111/j.1467-7687.2009.00869.x
Franklin A., 2011, NEW DIRECTIONS COLOU
Fujita T, 2011, RES AUTISM SPECT DIS, V5, P277, DOI 10.1016/j.rasd.2010.04.009
Grandin T., 1995, THINKING PICTURES OT
Heaton P, 2008, RES AUTISM SPECT DIS, V2, P147, DOI 10.1016/j.rasd.2007.04.004
Ishihara S., 1970, TESTS COLOUR BLINDNE
Jones RSP, 2003, J INTELLECT DEV DIS, V28, P112, DOI 10.1080/1366825031000147058
Koh H. C., 2011, NEUROPSYCHOLOGIA, V48, P4046
Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
Ludlow AK, 2009, J AUTISM DEV DISORD, V39, P815, DOI 10.1007/s10803-008-0672-5
Minshew NJ, 2008, J AUTISM DEV DISORD, V38, P1485, DOI 10.1007/s10803-007-0528-4
Moore S., 2004, GEORGE SAM
Munsell A. H., 1905, COLOR NOTATION
Ornitz E. M., 1989, AUTISM NATURE DIAGNO, P174
Palmer SE, 2010, P NATL ACAD SCI USA, V107, P8877, DOI 10.1073/pnas.0906172107
Poggio T., 2002, PERCEPTUAL LEARNING
Raven J. C., 1992, STANDARD PROGR MATRI
SNODGRASS JG, 1980, J EXP PSYCHOL-HUM L, V6, P174, DOI 10.1037/0278-7393.6.2.174
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
Wechsler D., 1992, UK MANUAL
WHITE BB, 1987, MED HYPOTHESES, V24, P223, DOI 10.1016/0306-9877(87)90068-5
Williams D., 1999, COLOUR BLIND
NR 33
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1355-4794
EI 1465-3656
J9 NEUROCASE
JI Neurocase
PD MAY 4
PY 2014
VL 20
IS 3
BP 296
EP 306
DI 10.1080/13554794.2013.770880
PG 11
WC Clinical Neurology; Psychiatry; Psychology
SC Neurosciences & Neurology; Psychiatry; Psychology
GA 301AK
UT WOS:000330504900007
PM 23547979
ER
PT J
AU Heavner, K
Newschaffer, C
Hertz-Picciotto, I
Bennett, D
Burstyn, I
AF Heavner, Karyn
Newschaffer, Craig
Hertz-Picciotto, Irva
Bennett, Deborah
Burstyn, Igor
TI Quantifying the potential impact of measurement error in an
investigation of autism spectrum disorder (ASD)
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID COVARIATE MEASUREMENT ERROR; LOGISTIC-REGRESSION; RISK-FACTORS; MODEL;
EXPOSURES; SCALE; SEX
AB The Early Autism Risk Longitudinal Investigation (EARLI), an ongoing study of a risk-enriched pregnancy cohort, examines genetic and environmental risk factors for autism spectrum disorders (ASDs). We simulated the potential effects of both measurement error (ME) in exposures and misclassification of ASD-related phenotype (assessed as Autism Observation Scale for Infants (AOSI) scores) on measures of association generated under this study design. We investigated the impact on the power to detect true associations with exposure and the false positive rate (FPR) for a non-causal correlate of exposure (X-2, r= 0.7) for continuous AOSI score (linear model) versus dichotomised AOSI (logistic regression) when the sample size (n), degree of ME in exposure, and strength of the expected (true) OR (eOR)) between exposure and AOSI varied. Exposure was a continuous variable in all linear models and dichotomised at one SD above the mean in logistic models. Simulations reveal complex patterns and suggest that: (1) There was attenuation of associations that increased with eOR and ME; (2) The FPR was considerable under many scenarios; and (3) The FPR has a complex dependence on the eOR, ME and model choice, but was greater for logistic models. The findings will stimulate work examining cost-effective strategies to reduce the impact of ME in realistic sample sizes and affirm the importance for EARLI of investment in biological samples that help precisely quantify a wide range of environmental exposures.
C1 [Heavner, Karyn] Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA.
[Newschaffer, Craig; Burstyn, Igor] Drexel Univ, Sch Publ Hlth, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA.
[Hertz-Picciotto, Irva; Bennett, Deborah] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Burstyn, Igor] Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA.
RP Heavner, K (reprint author), Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Nesbit Hall,3215 Market St, Philadelphia, PA 19104 USA.
EM karynkh@aol.com
FU Autism Science Foundation [12-1002]
FX This study was funded by a postdoctoral grant from the Autism Science
Foundation (Grant number 12-1002).
CR Aibar L, 2012, J PERINAT MED, V40, P271, DOI 10.1515/jpm-2011-0137
Armstrong BG, 1996, AM J EPIDEMIOL, V144, P192
Austin PC, 2004, STAT MED, V23, P1159, DOI 10.1002/sim.1687
Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
Cangul MZ, 2009, STAT MED, V28, P2531, DOI 10.1002/sim.3633
Cannon TD, 2006, ANNU REV CLIN PSYCHO, V2, P267, DOI 10.1146/annurev.clinpsy.2.022305.095232
Carroll RJ, 1995, MEASUREMENT ERROR NO, VFirst
Christley R. M., 2010, OPEN EPIDEMIOL J, V3, P16
Connolly JJ, 2013, CHILD DEV, V84, P17, DOI 10.1111/j.1467-8624.2012.01838.x
de Vocht F, 2012, J EXPO SCI ENV EPID, V22, P352, DOI 10.1038/jes.2012.22
Ferrari P, 2008, STAT MED, V27, P6037, DOI 10.1002/sim.3444
Freedman LS, 2008, STAT MED, V27, P5195, DOI 10.1002/sim.3361
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Gustafson P, 2006, J ROY STAT SOC A STA, V169, P865, DOI 10.1111/j.1467-985X.2006.00436.x
Gustafson P, 2005, STAT SCI, V20, P111, DOI 10.1214/088342305000000098
Gustafson P., 2003, MEASUREMENT ERROR MI
Jurek AM, 2005, INT J EPIDEMIOL, V34, P680, DOI 10.1093/ije/dyi060
Leavey A, 2013, J PEDIATR-US, V162, P361, DOI 10.1016/j.jpeds.2012.07.040
Maldonado G, 1998, EPIDEMIOLOGY, V9, P432, DOI 10.1097/00001648-199807000-00014
Newschaffer CJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-7
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
STEFANSKI LA, 1985, ANN STAT, V13, P1335, DOI 10.1214/aos/1176349741
Wakefield J, 2010, GENET EPIDEMIOL, V34, P16, DOI 10.1002/gepi.20429
Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
White E, 2008, PRINCIPLES EXPOSURE, Vsecond
NR 25
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD MAY
PY 2014
VL 68
IS 5
BP 438
EP 445
DI 10.1136/jech-2013-202982
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CB0CY
UT WOS:000349294000004
PM 24470431
ER
PT J
AU Deriziotis, P
Graham, SA
Estruch, SB
Fisher, SE
AF Deriziotis, Pelagia
Graham, Sarah A.
Estruch, Sara B.
Fisher, Simon E.
TI Investigating Protein-protein Interactions in Live Cells Using
Bioluminescence Resonance Energy Transfer
SO Jove-Journal of Visualized Experiments
LA English
DT Article
DE Cellular Biology; Issue 87; Protein-protein interactions;
Bioluminescence Resonance Energy Transfer; Live cell; Transfection;
Luciferase; Yellow Fluorescent Protein; Mutations
ID DE-NOVO MUTATIONS; LANGUAGE DEFICITS; LIVING CELLS; SPEECH; BRET;
IDENTIFICATION; DISORDERS; AUTISM; DOMAIN; FOXP1
AB Assays based on Bioluminescence Resonance Energy Transfer (BRET) provide a sensitive and reliable means to monitor protein-protein interactions in live cells. BRET is the non-radiative transfer of energy from a 'donor' luciferase enzyme to an 'acceptor' fluorescent protein. In the most common configuration of this assay, the donor is Renilla reniformis luciferase and the acceptor is Yellow Fluorescent Protein (YFP). Because the efficiency of energy transfer is strongly distance-dependent, observation of the BRET phenomenon requires that the donor and acceptor be in close proximity. To test for an interaction between two proteins of interest in cultured mammalian cells, one protein is expressed as a fusion with luciferase and the second as a fusion with YFP. An interaction between the two proteins of interest may bring the donor and acceptor sufficiently close for energy transfer to occur. Compared to other techniques for investigating protein-protein interactions, the BRET assay is sensitive, requires little hands-on time and few reagents, and is able to detect interactions which are weak, transient, or dependent on the biochemical environment found within a live cell. It is therefore an ideal approach for confirming putative interactions suggested by yeast two-hybrid or mass spectrometry proteomics studies, and in addition it is well-suited for mapping interacting regions, assessing the effect of post-translational modifications on protein-protein interactions, and evaluating the impact of mutations identified in patient DNA.
C1 [Deriziotis, Pelagia; Graham, Sarah A.; Estruch, Sara B.; Fisher, Simon E.] Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands.
[Fisher, Simon E.] Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
RP Fisher, SE (reprint author), Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands.
EM simon.fisher@mpi.nl
RI Derizioti, Pelagia/C-3857-2015; Fisher, Simon/E-9130-2012
OI Derizioti, Pelagia/0000-0001-5544-8345; Fisher,
Simon/0000-0002-3132-1996
FU Max Planck Society
FX This work was supported by the Max Planck Society.
CR Berggard T, 2007, PROTEOMICS, V7, P2833, DOI 10.1002/pmic.200700131
Boute N, 2001, MOL PHARMACOL, V60, P640
Boute N, 2002, TRENDS PHARMACOL SCI, V23, P351, DOI 10.1016/S0165-6147(02)02062-X
Ciruela F, 2008, CURR OPIN BIOTECH, V19, P338, DOI 10.1016/j.copbio.2008.06.003
Deriziotis P, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-4-204
Fisher SE, 2009, TRENDS GENET, V25, P166, DOI 10.1016/j.tig.2009.03.002
Gingras AC, 2007, NAT REV MOL CELL BIO, V8, P645, DOI 10.1038/nrm2208
Graham SA, 2013, CURR OPIN NEUROBIOL, V23, P43, DOI 10.1016/j.conb.2012.11.006
Green MR, 2012, MOL CLONING LAB MANU, VFourth
Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017
Horn D, 2010, HUM MUTAT, V31, pE1851, DOI 10.1002/humu.21362
Kocan M., 2011, FRONTIERS ENDOCRINOL, V1
Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
Li SR, 2004, MOL CELL BIOL, V24, P809, DOI 10.1128/MCB.24.2.809-822.2004
MacDermot KD, 2005, AM J HUM GENET, V76, P1074, DOI 10.1086/430841
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Perroy J, 2004, NAT METHODS, V1, P203, DOI 10.1038/NMETH722
Pfleger KDG, 2006, NAT METHODS, V3, P165, DOI 10.1038/nmeth841
Pfleger KDG, 2006, CELL SIGNAL, V18, P1664, DOI 10.1016/j.cellsig.2006.01.004
Roduit R, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007379
Suter B, 2008, CURR OPIN BIOTECH, V19, P316, DOI 10.1016/j.copbio.2008.06.005
Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
Vernes SC, 2006, HUM MOL GENET, V15, P3154, DOI 10.1093/hmg/ddl392
NR 23
TC 1
Z9 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD MAY
PY 2014
IS 87
AR e51438
DI 10.3791/51438
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA4VV
UT WOS:000348905400050
ER
PT J
AU Hahn, LJ
Zimmer, BJ
Brady, NC
Romine, RES
Fleming, KK
AF Hahn, Laura J.
Zimmer, B. Jean
Brady, Nancy C.
Romine, Rebecca E. Swinburne
Fleming, Kandace K.
TI Role of Maternal Gesture Use in Speech Use by Children With Fragile X
Syndrome
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE fragile X syndrome; gesture; language development; speech
ID AUTISM SPECTRUM DISORDER; LANGUAGE-DEVELOPMENT; YOUNG-CHILDREN;
DOWN-SYNDROME; JOINT ATTENTION; DEVELOPMENTAL DELAYS;
PRESCHOOL-CHILDREN; SPOKEN LANGUAGE; VERBAL LABELS; COMMUNICATION
AB Purpose: The purpose of this study was to investigate how maternal gesture relates to speech production by children with fragile X syndrome (FXS).
Method: Participants were 27 young children with FXS (23 boys, 4 girls) and their mothers. Videotaped home observations were conducted between the ages of 25 and 37 months (toddler period) and again between the ages of 60 and 71 months (child period). The videos were later coded for types of maternal utterances and maternal gestures that preceded child speech productions. Children were also assessed with the Mullen Scales of Early Learning at both ages.
Results: Maternal gesture use in the toddler period was positively related to expressive language scores at both age periods and was related to receptive language scores in the child period. Maternal proximal pointing, in comparison to other gestures, evoked more speech responses from children during the mother-child interactions, particularly when combined with wh-questions.
Conclusion: This study adds to the growing body of research on the importance of contextual variables, such as maternal gestures, in child language development. Parental gesture use may be an easily added ingredient to parent-focused early language intervention programs.
C1 [Hahn, Laura J.; Zimmer, B. Jean; Brady, Nancy C.; Romine, Rebecca E. Swinburne; Fleming, Kandace K.] Univ Kansas, Lawrence, KS 66045 USA.
RP Hahn, LJ (reprint author), Univ Kansas, Lawrence, KS 66045 USA.
EM laura.j.hahn@ku.edu
CR Abbeduto L, 2005, TRENDS LANG ACQUIS R, V4, P53
Abbeduto L, 1997, MENT RETARD DEV D R, V3, P313, DOI 10.1002/(SICI)1098-2779(1997)3:4<313::AID-MRDD6>3.0.CO;2-O
Abbeduto L, 2007, MENT RETARD DEV D R, V13, P36, DOI 10.1002/mrdd.20142
ABRAHAMSEN A, 1985, MERRILL PALMER QUART, V31, P177
AKHTAR N, 1991, J CHILD LANG, V18, P41
BAKEMAN R, 1986, INFANT BEHAV DEV, V9, P215, DOI 10.1016/0163-6383(86)90030-5
Bangerter A, 2004, PSYCHOL SCI, V15, P415, DOI 10.1111/j.0956-7976.2004.00694.x
Bangs T. E., 1979, BIRTH TO THREE DEVEL
BATES E., 1976, LANGUAGE CONTEXT
BATES E, 1975, MERRILL PALMER QUART, V21, P205
Bayley N, 1993, BAYLEY SCALES OF INF, V2nd
Beck AR, 2003, AM J SPEECH-LANG PAT, V12, P51, DOI 10.1044/1058-0360(2003/052)
Brady N, 2006, AM J SPEECH-LANG PAT, V15, P353, DOI 10.1044/1058-0360(2006/033)
Brady N. C., 2007, SPEECH LANGUAGE DEV, P173
Brady NC, 2004, J SPEECH LANG HEAR R, V47, P663, DOI 10.1044/1092-4388(2004/051)
Buschmann A, 2009, ARCH DIS CHILD, V94, P110, DOI 10.1136/adc.2008.141572
Capirci O, 1996, J CHILD LANG, V23, P645
Capone NC, 2004, J SPEECH LANG HEAR R, V47, P173, DOI [10.1044/1092-4388(2004/015), 10.1044/1092-4388(2004/15)]
Caselli MC, 1998, J SPEECH LANG HEAR R, V41, P1125
Centers for Disease Control and Prevention, 2011, FMR1 AND THE FRAGILE
Chan J. B., 2001, AAC AUGMENTATIVE ALT, V17, P73, DOI [10.1080/aac.17.2.73.87, DOI 10.1080/AAC.17.2.73.87]
Crawford DC, 2001, GENET MED, V3, P359, DOI 10.1097/00125817-200109000-00006
Demark JL, 2003, AM J MENT RETARD, V108, P314, DOI 10.1352/0895-8017(2003)108<314:BRBAAF>2.0.CO;2
Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
Venker CE, 2012, AUTISM, V16, P568, DOI 10.1177/1362361311413396
TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
Fernald A., 2008, PAPER PRESENTED AT T
Fey ME, 2006, J SPEECH LANG HEAR R, V49, P526, DOI 10.1044/1092-4388(2006/039)
Flenthrope JL, 2010, AM J SPEECH-LANG PAT, V19, P135, DOI 10.1044/1058-0360(2009/09-0018)
Folio M. R., 1983, PEABODY DEVELOPMENTA
FOLVEN RJ, 1991, DEV PSYCHOL, V27, P806, DOI 10.1037/0012-1649.27.5.806
Girolametto L., 2006, TREATMENT LANGUAGE D, P77
Gogate LJ, 2000, CHILD DEV, V71, P878, DOI 10.1111/1467-8624.00197
MORFORD M, 1992, J CHILD LANG, V19, P559
Goodhart F., 1993, FIRST LANG, V13, P225, DOI [10.1177/014272379301303804, DOI 10.1177/014272379301303804]
Goodwyn SW, 2000, J NONVERBAL BEHAV, V24, P81, DOI 10.1023/A:1006653828895
Hagerman R. J., 2007, SPEECH LANGUAGE DEV, P27
Hagerman RJ, 2008, CURR PEDIAT REV, V4, P40, DOI DOI 10.2174/157339608783565770
Harris NGS, 1997, DEV NEUROPSYCHOL, V13, P345
Hart B., 1991, FIRST LANG, V11, P289
Hatton DD, 2009, AJIDD-AM J INTELLECT, V114, P161, DOI 10.1352/1944-7558-114.3.161
Ingersoll B, 2010, J SPEECH LANG HEAR R, V53, P1040, DOI 10.1044/1092-4388(2009/09-0043)
Iverson JM, 1999, COGNITIVE DEV, V14, P57, DOI 10.1016/S0885-2014(99)80018-5
Iverson JM, 2005, PSYCHOL SCI, V16, P367, DOI 10.1111/j.0956-7976.2005.01542.x
Iverson JM, 2006, INT J LANG COMM DIS, V41, P235, DOI 10.1080/13682820500312151
Kaufmann WE, 2004, AM J MED GENET A, V129A, P225, DOI 10.1002/ajmg.a.30229
Kita S., 2003, POINTING WHERE LANGU
LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
Landry SH, 2006, DEV PSYCHOL, V42, P627, DOI 10.1037/0012-1649.42.4.627
LANDRY SH, 1989, CHILD DEV, V60, P103, DOI 10.1111/j.1467-8624.1989.tb02700.x
Legerstee M, 2002, J CHILD LANG, V29, P23, DOI 10.1017/S0305000901004895
Liszkowski U, 2004, DEVELOPMENTAL SCI, V7, P297, DOI 10.1111/j.1467-7687.2004.00349.x
Loesch DZ, 2004, MENT RETARD DEV D R, V10, P31, DOI 10.1002/mrdd.20006
Louwerse MM, 2010, COGNITIVE SCI, V34, P1517, DOI 10.1111/j.1551-6709.2010.01135.x
Masur E. F., 1990, FROM GESTURE TO LANG, P18
McDuffie A, 2013, TOP EARLY CHILD SPEC, V33, P172, DOI 10.1177/0271121413476348
McGregor KK, 2009, J CHILD LANG, V36, P807, DOI 10.1017/S0305000908009173
MCLEAN JE, 1991, J SPEECH HEAR RES, V34, P294
McNeil NM, 2000, J NONVERBAL BEHAV, V24, P131, DOI 10.1023/A:1006657929803
Mirrett PL, 2004, J DEV BEHAV PEDIATR, V25, P21, DOI 10.1097/00004703-200402000-00004
Misangyi VF, 2006, ORGAN RES METHODS, V9, P5, DOI 10.1177/1094428105283190
Moore C, 1999, DEV PSYCHOL, V35, P60, DOI 10.1037/0012-1649.35.1.60
Mullen EM, 1995, MULLEN SCALES OF EAR
Namy LL, 2000, J NONVERBAL BEHAV, V24, P63, DOI 10.1023/A:1006601812056
NINIO A, 1978, J CHILD LANG, V5, P1
Noldus Information Technology, 2002, THE OBSERVER BASE PA
O'Neill M, 2005, DEVELOPMENTAL SCI, V8, P352, DOI 10.1111/j.1467-7687.2005.00423.x
Ozcaliskan S., 2005, COGNITION, V96, P101, DOI [10.1016/j.cognition.2005.01.001, DOI 10.1016/J.C0GNITI0N.2005.01.001]
Philofsky A, 2004, AM J MENT RETARD, V109, P208, DOI 10.1352/0895-8017(2004)109<208:LACFAA>2.0.CO;2
RATNER N, 1978, J CHILD LANG, V5, P391
Roach MA, 1998, DEV PSYCHOL, V34, P77, DOI 10.1037/0012-1649.34.1.77
Roberts J., 2001, AM J MENT RETARD, V106, P177, DOI [10.1352/0895-8017(2001)106, DOI 10.1352/0895-8017(2001)106]
Roberts J., 2001, J EARLY INTERVENTION, V24, P207, DOI 10.1177/10538151010240030601
Roberts JE, 2002, AM J SPEECH-LANG PAT, V11, P295, DOI 10.1044/1058-0360(2002/034)
Roberts JE, 2009, J PEDIATR PSYCHOL, V34, P827, DOI 10.1093/jpepsy/jsn129
Rowe ML, 2009, SCIENCE, V323, P951, DOI 10.1126/science.1167025
Saxon TF, 1997, MERRILL PALMER QUART, V43, P48
Schmidt CL, 1996, J CHILD LANG, V23, P279
Schopler E., 1988, THE CHILDHOOD AUTISM
Shatz M., 1982, LANG ACQUIS, P102
SHERMAN SL, 1984, ANN HUM GENET, V48, P21, DOI 10.1111/j.1469-1809.1984.tb00830.x
Soto G, 1997, AUGMENTATIVE ALTERNA, V13, P186, DOI DOI 10.1080/07434619712331278008
Stone WL, 1997, J ABNORM CHILD PSYCH, V25, P475, DOI 10.1023/A:1022685731726
Stone WL, 2001, AUTISM, V5, P341, DOI 10.1177/1362361301005004002
Talbott MR, 2015, J AUTISM DEV DISORD, V45, P4, DOI 10.1007/s10803-013-1820-0
TFOUNI LV, 1983, J CHILD LANG, V10, P123
Tomasello M, 2007, CHILD DEV, V78, P705, DOI 10.1111/j.1467-8624.2007.01025.x
Tomasello M., 1988, LANG SCI, V10, P69, DOI 10.1016/0388-0001(88)90006-X
Trevarthen C, 2001, J CHILD PSYCHOL PSYC, V42, P3, DOI 10.1017/S0021963001006552
Turner G, 1996, AM J MED GENET, V64, P196, DOI 10.1002/(SICI)1096-8628(19960712)64:1<196::AID-AJMG35>3.0.CO;2-G
UCLA Statistical Consulting Group, 2013, STATA FAQ HOW DO I I
Van Hecke AV, 2007, CHILD DEV, V78, P53
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Vygotsky L. S., 1978, MIND IN SOCIETY THE
Wang X.-L., 2001, INT J EARLY YEARS ED, V9, P71, DOI 10.1080/09669760125651
Warren S., 2008, SPEECH LANGUAGE DEV, P53
Warren SF, 2010, AJIDD-AM J INTELLECT, V115, P54, DOI 10.1352/1944-7558-115.1.54
Watson LR, 2013, AM J SPEECH-LANG PAT, V22, P25, DOI 10.1044/1058-0360(2012/11-0145)
WOOD D, 1976, J CHILD PSYCHOL PSYC, V17, P89, DOI 10.1111/j.1469-7610.1976.tb00381.x
Zammit M, 2011, J CHILD LANG, V38, P201, DOI 10.1017/S0305000909990328
NR 100
TC 1
Z9 1
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
EI 1558-9110
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD MAY
PY 2014
VL 23
IS 2
BP 146
EP 159
DI 10.1044/2013_AJSLP-13-0046
PG 14
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AU5ZP
UT WOS:000345682200005
PM 24686460
ER
PT J
AU Ronald, A
Larsson, H
Anckarsater, H
Lichtenstein, P
AF Ronald, Angelica
Larsson, Henrik
Anckarsater, Henrik
Lichtenstein, Paul
TI Symptoms of Autism and ADHD: A Swedish Twin Study Examining Their
Overlap
SO JOURNAL OF ABNORMAL PSYCHOLOGY
LA English
DT Article
DE autism; ADHD; twins; comorbidity; genetics
ID DEFICIT-HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; SUBSTANTIAL GENETIC OVERLAP; SPECTRUM DISORDERS; DSM-IV;
PSYCHIATRIC-DISORDERS; SOCIAL-COMMUNICATION; GENERAL-POPULATION;
COMMUNITY TWIN; TRAITS
AB Autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) show high comorbidity. The following questions were addressed regarding their specific symptoms: What is the factor structure of ASD and ADHD symptoms, to what degree do different symptom domains cluster together, to what extent are these domains caused by the same genetic and environmental influences, and what is the best model of their co-occurrence? A population-based twin cohort of over 17,000 9- and 12-year-olds were assessed using the Autism-Tics, AD/HD, and other Comorbidities parental interview inventory. Principal component analyses were conducted, and symptom domain clustering was assessed. Four multivariate twin models were compared. Factors split into three ASD (social impairments, communication impairments, and restricted repetitive behaviors and interests), and three ADHD (inattention, hyperactivity, and impulsivity) symptom domains. Some ASD-ADHD symptom domain combinations clustered together often, although others not at all. A two-factor common pathway model fit the data, suggesting that ASD and ADHD symptom domains tap into separate "ASD" and "ADHD" latent factors that showed high genetic overlap. All subdomains also showed significant specific genetic and environmental influences, reflecting the etiological heterogeneity both within and between ASD and ADHD. These findings support the conceptual distinction of ASD and ADHD, and demonstrate the considerable natural co-occurrence of particular ASD/ADHD symptom domains. The results imply that more children with 1 condition show features of the other condition than show complete comorbidity. Emphasis on symptom co-occurrence, rather than complete comorbidity between disorders, may help focus clinical approaches and advance molecular genetic research.
C1 [Ronald, Angelica] Univ London, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
[Larsson, Henrik; Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Larsson, Henrik] Karolinska Inst, Ctr Neurodev Disorders, Stockholm, Sweden.
[Anckarsater, Henrik] Gothenburg Univ, Inst Neurosci & Physiol, Sahlgrens Acad, S-41124 Gothenburg, Sweden.
RP Ronald, A (reprint author), Univ London, Ctr Brain & Cognit Dev, Dept Psychol Sci, Malet St, London WC1E 7HX, England.
EM a.ronald@bbk.ac.uk
RI Ronald, Angelica/C-7812-2009
OI Ronald, Angelica/0000-0002-9576-2176
CR AKAIKE H, 1987, PSYCHOMETRIKA, V52, P317, DOI 10.1007/BF02294359
Anckarsater H, 2008, OPEN PSYCHIAT J, V2, P5, DOI DOI 10.2174/1874354400802010005
Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
Asherson Philip, 2012, Curr Top Behav Neurosci, V9, P239, DOI 10.1007/7854_2011_155
Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50
Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
Curran S, 2011, AUTISM RES, V4, P377, DOI 10.1002/aur.207
Dworzynski K, 2009, J AUTISM DEV DISORD, V39, P1197, DOI 10.1007/s10803-009-0736-1
Fan Xueliang, 2012, Curr Top Behav Neurosci, V9, P273, DOI 10.1007/7854_2011_121
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Ghanizadeh A, 2012, J RES MED SCI, V17, P368
Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
Gomez R, 2013, J ATTEN DISORD, DOI [10.1177/ 1087054713485206, DOI 10.1177/1087054713485206, 10.1177/1087054713485206]
Greven CU, 2011, J ABNORM CHILD PSYCH, V39, P265, DOI 10.1007/s10802-010-9451-9
Hansson SL, 2005, BRIT J PSYCHIAT, V187, P262, DOI 10.1192/bjp.187.3.262
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
Ho A, 2005, J AUTISM DEV DISORD, V35, P129, DOI 10.1007/s10803-004-1040-8
Insel T., 2013, TRANSFORMING DIAGNOS
Langley K, 2010, ARCH GEN PSYCHIAT, V67, P1317, DOI 10.1001/archgenpsychiatry.2010.163
Larsson H, 2006, J AM ACAD CHILD PSY, V45, P973, DOI 10.1097/01.chi.0000222787.57100.d8
Larsson H, 2012, J CHILD PSYCHOL PSYC, V53, P73, DOI 10.1111/j.1469-7610.2011.02467.x
Lecavalier L, 2009, J CHILD PSYCHOL PSYC, V50, P1246, DOI 10.1111/j.1469-7610.2009.02104.x
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
Lundstrom S, 2011, PSYCHOL MED, V41, P2423, DOI 10.1017/S0033291711000377
Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
Markon KE, 2004, BEHAV GENET, V34, P593, DOI 10.1007/s10519-004-5587-0
McDonald JH, 2009, HDB BIOL STAT
McLoughlin G, 2007, J ABNORM CHILD PSYCH, V35, P999, DOI 10.1007/s10802-007-9149-9
Moilanen I, 1999, EUR CHILD ADOLES PSY, V8, P62
Mulligan A, 2009, J AUTISM DEV DISORD, V39, P197, DOI 10.1007/s10803-008-0621-3
Neale M. C., 2003, MX STAT MODELING, V6th
Nordenbaek C, 2014, EUR CHILD ADOLES PSY, V23, P35, DOI 10.1007/s00787-013-0419-5
Plomin R., 2008, BEHAV GENETICS
Polderman TJC, 2013, PSYCHOL MED, V43, P1985, DOI 10.1017/S0033291712002863
Posthuma D, 2013, CURR OPIN NEUROL, V26, P111, DOI 10.1097/WCO.0b013e32835f19c3
Raftery AE, 1995, SOCIOL METHODOL, V25, P111, DOI 10.2307/271063
Reiersen Angela M, 2011, J Can Acad Child Adolesc Psychiatry, V20, P15
Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Reiersen AM, 2008, J AM ACAD CHILD PSY, V47, P662, DOI 10.1097/CHI.0b013e31816bff88
Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
Ronald A, 2008, EUR CHILD ADOLES PSY, V17, P473, DOI 10.1007/s00787-008-0689-5
Ronald A, 2011, MOL PSYCHIATR, V16, P1039, DOI 10.1038/mp.2010.82
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Ronald A, 2010, BEHAV GENET, V40, P31, DOI 10.1007/s10519-009-9308-6
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Ronald A, 2010, J ABNORM CHILD PSYCH, V38, P185, DOI 10.1007/s10802-009-9366-5
Rutter M., 1994, CLIN PSYCHOL-SCI PR, V1, P100, DOI 10.1111/j.1468-2850.1994.tb00012.x
Sham P, 1998, STAT HUMAN GENETICS
SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Simonoff E, 1998, PSYCHOL MED, V28, P825, DOI 10.1017/S0033291798006886
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Smith Lauren C, 2013, Atten Defic Hyperact Disord, V5, P9, DOI 10.1007/s12402-012-0091-5
SPSS, 2009, PASW STAT WIND VERS
St Pourcain B, 2011, J AM ACAD CHILD PSY, V50, P892, DOI 10.1016/j.jaac.2011.05.015
Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
Taylor M., PSYCHOL MED IN PRESS
Toplak ME, 2012, J CHILD PSYCHOL PSYC, V53, P292, DOI 10.1111/j.1469-7610.2011.02500.x
Willcutt E, 2012, NEUROTHERAPEUTICS, V9, P490, DOI 10.1007/s13311-012-0135-8
Willcutt EG, 2012, J ABNORM PSYCHOL, V121, P991, DOI 10.1037/a0027347
NR 66
TC 2
Z9 2
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-843X
EI 1939-1846
J9 J ABNORM PSYCHOL
JI J. Abnorm. Psychol.
PD MAY
PY 2014
VL 123
IS 2
BP 440
EP 451
DI 10.1037/a0036088
PG 12
WC Psychology, Clinical; Psychology, Multidisciplinary
SC Psychology
GA AS1AF
UT WOS:000344007600016
PM 24731073
ER
PT J
AU Pearn, J
AF Pearn, John
TI Professor Tyndale John Rendle-Short (1919-2010), British and Australian
paediatrician: A life in two domains
SO JOURNAL OF MEDICAL BIOGRAPHY
LA English
DT Article
DE Paediatrics; medical history; Rendle-Short kindred; theology; medical
education
ID INFANTILE AUTISM
AB Professor Tyndale John Rendle-Short (1919-2010), a British and Australian paediatrician, lived a professional life of considerable influence in two domains - academic paediatrics and fundamentalist theology. A Cambridge medical graduate (1943) and doctor-soldier, he was appointed as the Foundation Professor of Child Health at the University of Queensland (1961). In Australia, he was a pioneer in three paediatric developments ('rooming-in' for mothers in hospitals, autism research and cystic fibrosis). His A Synopsis of Children's Diseases was published in six editions, was translated into three languages and was used as a standard paediatric textbook on four Continents. Distinct from this clinical domain, as a passionate anti-Darwinist his fundamentalist theology was that variously self-described as 'theistic evolution' (believing in 'progressive Creationism') and later that of 'six-literal day young-earth Creation'. He established and was the Foundation Chairman of the Creation Science Foundation (UK) and was World Chairman of the US-based Creation Ministries International. This biography is a record of this perhaps paradoxical and unique life.
C1 Royal Childrens Hosp, Dept Paediat & Child Hlth, Brisbane, Qld 4029, Australia.
RP Pearn, J (reprint author), Royal Childrens Hosp, Dept Paediat & Child Hlth, Brisbane, Qld 4029, Australia.
EM j.pearn@uq.edu.au
CR [Anonymous], 1953, TIMES, P8
[Anonymous], 1997, CREATION, V19, P50
BURROWS NFE, 1951, BRIT MED J, V1, P329
CLANCY H, 1969, DEV MED CHILD NEUROL, V11, P432
CLANCY H, 1969, DEV MED CHILD NEUROL, V11, P569
Connell HM, 1979, ESSENTIALS CHILD PSY
Earnshaw P A, 1969, Med J Aust, V2, P928
Ham K., 2010, TRIBUTE PIONEER
Herbert A, 2010, LUKES J CHRISTIAN ME, V15, P28
Holt KS, 1964, LANCET, Vii, P1144
Illingworth RS, 1957, LANCET, V11, P653
LORBER JOHN, 1961, QUART REV PEDIATRICS, V16, P93
Pearn J, 1986, FOCUS INNOVATION HIS, P163
PEARN J, 1984, AUST PAEDIATR J, V20, P175
Pearn J, 1999, GLOBAL ERADICATION D, V5, P11
Pearn J. H., 1986, FOCUS INNOVATION HIS, P165
Pearn JH, 2012, SYMBOLS SERVICE, P48
PEARN JH, 1970, PRACTITIONER, V204, P34
Rendle-Short, 1985, COMMUNICATION
Rendle-Short Francesca, 2010, HECATE, V36, P57
RENDLESH.J, 1973, AUST PAEDIATR J, V9, P263
Rendle-Short J, 1984, SYNOPSIS CHILDRENS D
Rendle-Short J., 1977, CHILD GUIDE PAEDIAT
Rendle-Short J., 1960, P ROY SOC MED, V48, P132
Rendle-Short J, 1966, LIFE W CADOGAN FATHE
RENDLESHORT J, 1956, ARCH DIS CHILD, V31, P28
Rendle-Short J, 1961, SYNOPSIS PHYSL
RENDLE-SHORT J, 1960, Bull Hist Med, V34, P97
Rendle-Short J, 1976, MED J AUSTRALIA, V1, P756
RENDLE-SHORT J, 1960, Med Hist, V4, P288
RENDLESH.J, 1969, MED J AUSTRALIA, V2, P245
RENDLESHORT J, 1962, MED J AUSTRALIA, V1, P632
Rendle-Short TJ, 1981, CREATION MAGAZINE, P4
Rendle-Short TJ, 1965, AUSTR PAEDIAT J, V1, P98
Rendle-Short TJ, 1991, REASONABLE CHRISTIAN
Rendle-Short TJ, 1998, GREEN EYE STORM
Rendle-Short TJ, COMMUNICATION
Rendle-Short TJ, 1984, MAN APE IMAGE CHRIST
Travers E, 1956, LANCET, Vii, P113
Tudehope DI, 1984, PRIMER NEONATAL MED
Tulloch A., 1976, PAEDIAT STUDENT
NR 41
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0967-7720
EI 1758-1087
J9 J MED BIOGR
JI J. Med. Biogr.
PD MAY
PY 2014
VL 22
IS 2
BP 63
EP 70
DI 10.1177/0967772013479508
PG 8
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA AQ1XA
UT WOS:000342576400002
ER
PT J
AU Ranft, P
AF Ranft, Patricia
TI Ruminations on Hildegard of Bingen (1098-1179) and autism
SO JOURNAL OF MEDICAL BIOGRAPHY
LA English
DT Article
DE Hildegard of Bingen; autism; Asperger; monasticism
ID DIAGNOSIS
AB The article brings together contemporary research on autism spectrum disorder and historical sources concerning the medical condition of a 12th century nun, Hildegard of Bingen, to test two hypotheses: first, that Hildegard manifested disabilities that meet the criteria for autism spectrum disorder and, second, that medieval monasticism was unwittingly well-suited to treat Hildegard's condition. Abundant Hildegardian sources document traces of autism spectrum disorder behaviour in Hildegard's unusual childhood and the composite picture that emerges, when these individual traits are gathered together, is consistent with an autism spectrum disorder diagnosis. The role monasticism played in helping Hildegard overcome these behaviours is documented and aspects that monasticism shares with modern autism spectrum disorder treatment programs are identified. By recognizing the presence of autism spectrum disorder traits in a major cultural leader of another era and by identifying the type of life she lived while those traits were minimized, we gain insight into the history of autism, medieval monastic life and effective elements of autism spectrum disorder treatment.
C1 [Ranft, Patricia] Cent Michigan Univ, Mt Pleasant, MI USA.
RP Ranft, P (reprint author), 133 Hampton Rd Ave, Hampton, VA 23661 USA.
EM ranft1p@cmich.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN DIS T
Baird J, 1994, LETT HILDEGARD BINGE
Baron-Cohen S., 2004, ESSENTIAL DIFFERENCE, P168
Berger M, 1999, NATURAL PHILOS SELEC, P56
Dawson G., 1997, EFFECTIVENESS EARLY, P307
DEYKIN EY, 1979, AM J PSYCHIAT, V136, P1310
Dronke P., 2001, WOMEN WRITERS MIDDLE, P147
Filipek PA, 2000, NEUROLOGY, V55, P468
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Filogano G, 1997, BRAIN PLASTICITY
Flanagan S., 1998, HILDEGARD BINGEN 109, P199
Frith U, 1991, AUTISM ASPERGER SYND
Glaze F, 1990, VOICE LIVING LIGHT, P135
Grafma J, 1999, NEURONAL PLASTICITY
Hart C, 1990, SCIVIAS
Hozeski B., 1994, BOOK REWARDS LIFE, P9
Kanner L, 1943, NERV CHILD, V2, P217
Ranft P., 2002, WOMEN W INTELLECTUAL, P55
Ranft P., 2012, DOCTRINE INCARNATION
Sachs O., 1985, MIGRAINES, P106
Schnapp J, 1991, EXEMPLARIA, V3, P272
Silvas A, 1998, JUTTA HILDEGARD BIOG
Wetherby A, 2001, AUTISM SPECTRUM DISO, P121
Wing L, 1976, EARLY CHILDHOOD AUTI, P3
Wittenstein L, 1929, OUR KNOWLEDGE EXTERN, P42
Yapko D., 2003, UNDERSTANDING AUTISM
NR 26
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0967-7720
EI 1758-1087
J9 J MED BIOGR
JI J. Med. Biogr.
PD MAY
PY 2014
VL 22
IS 2
BP 107
EP 115
DI 10.1177/0967772013479283
PG 10
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA AQ1XA
UT WOS:000342576400009
ER
PT J
AU Chok, JT
Koesler, B
AF Chok, James T.
Koesler, Bryan
TI Distinguishing Obsessive-Compulsive Behavior From Stereotypy: A
Preliminary Investigation
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE stereotypy; ritualistic and repetitive behavior; physiology;
Obsessive-Compulsive Disorder
ID REPETITIVE BEHAVIORS; FUNCTIONAL-ANALYSIS; INTERESTS DOMAIN; DISORDER;
AUTISM; INDIVIDUALS; DISABILITIES; PARENTS
AB The current project was an initial attempt to develop assessment procedures for distinguishing between obsessive-compulsive (OC) and stereotypic behavior and evaluate the impact of different treatments for these behaviors. Two individuals with autism, one with repetitive behavior characteristic of OC behavior and one with repetitive behavior not characteristic of OC behavior, participated in the study. In Experiment 1, given that individuals with Obsessive-Compulsive Disorder (OCD) report experiencing unpleasant urges that are relieved when they perform compulsive actions, an attempt was made to identify these experiences by measuring heart rate and affect when access to repetitive behavior was restricted and allowed. In Experiment 2, a multiple schedules treatment was conducted with each participant, and in Experiment 3, the participant with autism and OC behavior completed exposure and response prevention (ERP) treatment. The overall results across studies suggest that one potential way to discriminate between OC behavior and stereotypy in nonvocal children with autism is to consider the topography of repetitive behavior along with changes in physiology and affect. In addition, it may be worth considering the use of ERP, a traditional treatment for OCD, to treat repetitive behavior maintained by automatic reinforcement if treatments that provide access to repetitive behavior are not effective.
C1 [Chok, James T.] Melmark Penn, Berwyn, PA 19312 USA.
[Koesler, Bryan] Massachusetts Sch Profess Psychol, Clin Psychol Program, Newton, MA USA.
RP Chok, JT (reprint author), Melmark Penn, 2600 Wayland Rd, Berwyn, PA 19312 USA.
EM JimChok@melmark.org
CR Abramson RK, 2005, CHILD PSYCHIAT HUM D, V36, P155, DOI 10.1007/s10578-005-2973-7
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bloch MH, 2008, AM J PSYCHIAT, V165, P1532, DOI 10.1176/appi.ajp.2008.08020320
BOULOUGOURIS JC, 1977, BEHAV RES THER, V15, P221, DOI 10.1016/0005-7967(77)90019-5
Brusa E., 2008, INT J BEHAV CONSULTA, V4, P264
CHARLOP MH, 1990, J APPL BEHAV ANAL, V23, P163, DOI 10.1901/jaba.1990.23-163
CUCCARO ML, 1993, J NEUROPSYCH CLIN N, V5, P94
Doughty SS, 2007, J EXP ANAL BEHAV, V87, P325, DOI 10.1901/jeab.2007.39-05
DUNLAP G, 1983, AM J MENT DEF, V88, P194
Foa EB, 1996, LONG TERM TREATMENTS, P285
Green CW, 1999, BEHAV MODIF, V23, P280, DOI 10.1177/0145445599232006
Hanley GP, 2000, J APPL BEHAV ANAL, V33, P285, DOI 10.1901/jaba.2000.33-285
Hollander E, 2003, PSYCHIAT RES, V117, P11, DOI 10.1016/S0165-1781(02)00304-9
HORNSVELD RHJ, 1979, BEHAV RES THER, V17, P223, DOI 10.1016/0005-7967(79)90037-8
Huey ED, 2008, J NEUROPSYCH CLIN N, V20, P390, DOI 10.1176/appi.neuropsych.20.4.390
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
JONES RSP, 1990, J MENT DEFIC RES, V34, P261
Jones RSP, 1999, BEHAV INTERVENT, V14, P45, DOI 10.1002/(SICI)1099-078X(199901/03)14:1<45::AID-BIN27>3.0.CO;2-0
Lehmkuhl HD, 2008, J AUTISM DEV DISORD, V38, P977, DOI 10.1007/s10803-007-0457-2
Lorenz K., 1981, FDN ETHOLOGY
Lotfizadeh A. D., 2012, BEHAV ANAL, V35, P162
Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
Rodriguez NM, 2012, J APPL BEHAV ANAL, V45, P1, DOI 10.1901/jaba.2012.45-1
Scahill L, 2006, J AM ACAD CHILD PSY, V45, P1114, DOI 10.1097/01.chi.0000220854.79144.e7
Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846
Smith CJ, 2009, J CHILD PSYCHOL PSYC, V50, P982, DOI 10.1111/j.1469-7610.2009.02060.x
Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x
Szechtman H, 2004, PSYCHOL REV, V111, P111, DOI 10.1037/0033-295X.111.1.111
Tinbergen N., 1948, Wilson Bulletin, V60, P6
Woody E. Z., 2005, BEHAV BRAIN FUNCT, V1, P1
NR 30
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD MAY
PY 2014
VL 38
IS 3
SI SI
BP 344
EP 373
DI 10.1177/0145445513509475
PG 30
WC Psychology, Clinical
SC Psychology
GA AQ3GW
UT WOS:000342680400002
ER
PT J
AU Enloe, KA
Rapp, JT
AF Enloe, Kimberley A.
Rapp, John T.
TI Effects of Noncontingent Social Interaction on Immediate and Subsequent
Engagement in Vocal and Motor Stereotypy in Children With Autism
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE motor stereotypy; noncontingent reinforcement; subsequent effects; vocal
stereotypy
ID MATCHED STIMULATION; RESPONSE INTERRUPTION; FUNCTIONAL-ANALYSIS;
SPECTRUM DISORDERS; BEHAVIOR; INDIVIDUALS; REDIRECTION; MUSIC; FORMS
AB This study evaluated the effects of noncontingent social interaction (SI) on immediate and subsequent engagement in vocal and motor stereotypy in three children with autism. During SI, a therapist delivered continuous interaction in the form of reading aloud from a Kindle T e-reader. Results showed that when compared with a no-interaction baseline sequence, SI decreased immediate engagement vocal stereotypy for all three participants without increasing subsequent engagement for any participant. Furthermore, SI also increased immediate engagement in motor stereotypy for one participant, decreased immediate engagement in motor stereotypy for two participants, but did not increase subsequent engagement in motor stereotypy for any participant. Some clinical implications and limitations of the findings are discussed.
C1 [Enloe, Kimberley A.] St Cloud State Univ, St Cloud, MN USA.
[Rapp, John T.] Auburn Univ, Behav Anal Program, Auburn, AL 36849 USA.
RP Rapp, JT (reprint author), Auburn Univ, Dept Psychol, 226 Thach, Auburn, AL 36849 USA.
EM jtr0014@auburn.edu
CR Athens ES, 2008, J APPL BEHAV ANAL, V41, P291, DOI 10.1901/jaba.2008.41-291
DiGennaro-Reed F. D., 2012, RES AUTISM SPECT DIS, V6, P422, DOI [10.1016/j.rasd.2011.07.003, DOI 10.1016/J.RASD.2011.07.003]
Guzinski Erin M, 2012, Anal Verbal Behav, V28, P101
Iwata Brian A, 2008, Behav Anal Pract, V1, P3
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Jones R. S. P., 1989, J INTELL DISABIL RES, V3, P261
KOEGEL RL, 1974, J APPL BEHAV ANAL, V7, P521, DOI 10.1901/jaba.1974.7-521
Lanovaz M. J., 2010, EUROPEAN J BEHAV ANA, V11, P17
Lanovaz MJ, 2013, J APPL BEHAV ANAL, V46, P544, DOI 10.1002/jaba.35
Lanovaz MJ, 2009, BEHAV MODIF, V33, P682, DOI 10.1177/0145445509344972
Lanovaz MJ, 2012, BEHAV INTERVENT, V27, P207, DOI 10.1002/bin.1345
Lanovaz MJ, 2012, BEHAV MODIF, V36, P146, DOI 10.1177/0145445511427192
Lanovaz MJ, 2013, RES AUTISM SPECT DIS, V7, P1234, DOI 10.1016/j.rasd.2013.07.009
Lanovaz MJ, 2011, J APPL BEHAV ANAL, V44, P647, DOI 10.1901/jaba.2011.44-647
Laraway S, 2003, J APPL BEHAV ANAL, V36, P407, DOI 10.1901/jaba.2003.36-407
Lovaas O. I., 2003, TEACHING INDIVIDUALS
Love JJ, 2012, J APPL BEHAV ANAL, V45, P549, DOI 10.1901/jaba.2012.45-549
Morrison K, 1997, RES DEV DISABIL, V18, P127, DOI 10.1016/S0891-4222(96)00046-7
Mudford OC, 2009, J APPL BEHAV ANAL, V42, P165, DOI 10.1901/jaba.2009.42-165
Neely L, 2013, RES AUTISM SPECT DIS, V7, P509, DOI 10.1016/j.rasd.2012.12.004
Pastrana SJ, 2013, BEHAV MODIF, V37, P591, DOI 10.1177/0145445513485751
Querim AC, 2013, J APPL BEHAV ANAL, V46, P47, DOI 10.1002/jaba.26
Rapp JT, 2007, J APPL BEHAV ANAL, V40, P73, DOI 10.1901/jaba.2007.142-05
Rapp JT, 2013, BEHAV MODIF, V37, P543, DOI 10.1177/0145445512461650
Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
Rapp JT, 2004, J APPL BEHAV ANAL, V37, P481, DOI 10.1901/jaba.2004.37-481
Rapp JT, 2006, J APPL BEHAV ANAL, V39, P137, DOI 10.1901/jaba.2006.37-05
Saylor S, 2012, J APPL BEHAV ANAL, V45, P185, DOI 10.1901/jaba.2012.45-185
SCHWARTZ SS, 1986, AM J MENT RETARD, V90, P625
Simmons JN, 2003, J APPL BEHAV ANAL, V36, P541, DOI 10.1901/jaba.2003.36-541
NR 30
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD MAY
PY 2014
VL 38
IS 3
SI SI
BP 374
EP 391
DI 10.1177/0145445513514081
PG 18
WC Psychology, Clinical
SC Psychology
GA AQ3GW
UT WOS:000342680400003
ER
PT J
AU Rispoli, M
Camargo, SH
Neely, L
Gerow, S
Lang, R
Goodwyn, F
Ninci, J
AF Rispoli, Mandy
Camargo, Siglia Hoher
Neely, Leslie
Gerow, Stephanie
Lang, Russell
Goodwyn, Fara
Ninci, Jennifer
TI Pre-Session Satiation as a Treatment for Stereotypy During Group
Activities
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE abolishing operation; stereotypy; automatically maintained behavior;
autism
ID CHALLENGING BEHAVIOR; DEVELOPMENTAL-DISABILITIES; AUTOMATIC
REINFORCEMENT; MOTIVATING OPERATIONS; VOCAL STEREOTYPY; STIMULI;
INTERVENTION; IMMEDIATE; CHILDREN; AUTISM
AB Individuals with developmental disabilities may engage in automatically reinforced behaviors that may interfere with learning opportunities. Manipulation of motivating operations has been shown to reduce automatically maintained behavior in some individuals. Considering behavioral indicators of satiation may assist in identifying the point at which an abolishing operation has begun to effect behavior. The purpose of this study was to evaluate the effects of pre-session satiation of automatic reinforcement on subsequent levels of stereotypy and activity engagement during group activities for three males ages 5 to 13 years with developmental disabilities. Following functional analyses with analogue conditions, an alternating treatment design compared a pre-session access to stereotypy condition with a no-presession access condition prior to group activity sessions. Results indicated that pre-session satiation of the putative reinforcer produced by stereotypy was effective in decreasing stereotypy and increasing activity engagement during subsequent group activities for all participants. These findings add to the literature supporting the effectiveness of abolishing operations to decrease automatically maintained stereotypy.
C1 [Rispoli, Mandy; Neely, Leslie; Gerow, Stephanie; Goodwyn, Fara] Texas A&M Univ, Dept Educ Psychol, College Stn, TX 77843 USA.
[Camargo, Siglia Hoher] Texas A&M Univ, College Stn, TX 77843 USA.
[Ninci, Jennifer] Texas A&M Univ, Dept Educ Psychol, Special Educ Program, College Stn, TX 77843 USA.
[Lang, Russell] Texas State Univ, Dept Curriculum & Instruct, San Marcos, TX USA.
[Lang, Russell] Texas State Univ, Clin Autism Res Evaluat & Support, San Marcos, TX USA.
RP Rispoli, M (reprint author), Texas A&M Univ, 4225 TAMU, College Stn, TX 77843 USA.
EM mrispoli@tamu.edu
CR Chung YC, 2010, BEHAV MODIF, V34, P479, DOI 10.1177/0145445510378380
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Lang R, 2009, J APPL BEHAV ANAL, V42, P889, DOI 10.1901/jaba.2009.42-889
Lang R, 2010, BEHAV MODIF, V34, P267, DOI 10.1177/0145445510370713
Lanovaz MJ, 2009, BEHAV MODIF, V33, P682, DOI 10.1177/0145445509344972
Lanovaz MJ, 2013, RES AUTISM SPECT DIS, V7, P1234, DOI 10.1016/j.rasd.2013.07.009
Laraway S, 2003, J APPL BEHAV ANAL, V36, P407, DOI 10.1901/jaba.2003.36-407
MacDonald R, 2007, RES DEV DISABIL, V28, P266, DOI 10.1016/j.ridd.2006.01.004
O'Reilly M, 2009, J APPL BEHAV ANAL, V42, P773, DOI 10.1901/jaba.2009.42-773
Piazza CC, 2000, J APPL BEHAV ANAL, V33, P13, DOI 10.1901/jaba.2000.33-13
Rapp JT, 2013, BEHAV MODIF, V37, P543, DOI 10.1177/0145445512461650
Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
Rapp JT, 2004, BEHAV INTERVENT, V19, P287, DOI 10.1002/bin.166
Rispoli M, 2011, J APPL BEHAV ANAL, V44, P187, DOI 10.1901/jaba.2011.44-187
Rispoli MJ, 2011, EDUC TRAIN AUTISM DE, V46, P607
Roantree CF, 2006, J APPL BEHAV ANAL, V39, P381, DOI 10.1901/jaba.2006.97-05
Simmons JN, 2003, J APPL BEHAV ANAL, V36, P541, DOI 10.1901/jaba.2003.36-541
VOLLMER TR, 1994, RES DEV DISABIL, V15, P187, DOI 10.1016/0891-4222(94)90011-6
NR 18
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD MAY
PY 2014
VL 38
IS 3
SI SI
BP 392
EP 411
DI 10.1177/0145445513511631
PG 20
WC Psychology, Clinical
SC Psychology
GA AQ3GW
UT WOS:000342680400004
ER
PT J
AU Watkins, N
Sparling, E
AF Watkins, Nicholas
Sparling, Elizabeth
TI The Effectiveness of the Snug Vest on Stereotypic Behaviors in Children
Diagnosed With an Autism Spectrum Disorder
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE autism; stereotypy; sensory integration; deep pressure; Snug Vest; QABF
ID SENSORY INTEGRATION THERAPY; SELF-INJURIOUS-BEHAVIOR; VOCAL STEREOTYPY;
FUNCTIONAL-ANALYSIS; WEIGHTED VESTS; NONCONTINGENT REINFORCEMENT;
DIFFERENTIAL REINFORCEMENT; AUTOMATIC REINFORCEMENT; DEVELOPMENTAL
DISORDERS; OCCUPATIONAL-THERAPY
AB Various reviews of the effects of sensory integration therapy (SIT) have concluded that such interventions fail to reduce stereotypy. However, a new, and as yet untested, SIT iteration, an inflatable wearable vest known as the Snug Vest purports to decrease such repetitive behavior. In the current study, three children who emitted different forms of stereotypy participated in an alternating treatments design in which each participant wore a fully inflated vest and either a fully deflated vest or no vest. The results of the study show that the Snug Vest failed to reduce any participants' stereotypy. We highlight our findings in the context of professional practice and discuss several potential limitations.
C1 [Watkins, Nicholas] Douglas Coll, Dept Disabil & Community Studies, New Westminster, BC V3L 5B2, Canada.
[Sparling, Elizabeth] Pivot Point Family Growth Ctr, Surrey, BC, Canada.
RP Watkins, N (reprint author), Douglas Coll, POB 2503, New Westminster, BC V3L 5B2, Canada.
EM watkinsn@douglascollege.ca
CR Ahearn WH, 2005, J APPL BEHAV ANAL, V38, P247, DOI 10.1901/jaba.2005.36-04
Ahearn WH, 2007, J APPL BEHAV ANAL, V40, P263, DOI 10.1901/jaba.2007.30-06
Ahrens EN, 2011, J APPL BEHAV ANAL, V44, P95, DOI 10.1901/jaba.2011.44-95
[Anonymous], 2013, CLIN SUPPORT
[Anonymous], INSTR MAN
[Anonymous], 2009, NAT STAND PROJ ADDR
Athens ES, 2008, J APPL BEHAV ANAL, V41, P291, DOI 10.1901/jaba.2008.41-291
Ayres A. J., 1974, DEV SENSORY INTEGRAT, P96
Ayres A. J., 1972, SENSORY INTEGRATION
Ayres AJ, 1979, SENSORY INTEGRATION
Bahrami F, 2012, RES DEV DISABIL, V33, P1183, DOI 10.1016/j.ridd.2012.01.018
Barlow D., 2009, SINGLE CASE EXPT DES
Beavers GA, 2011, J APPL BEHAV ANAL, V44, P593, DOI 10.1901/jaba.2011.44-593
Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
Britton LN, 2002, BEHAV INTERVENT, V17, P93, DOI 10.1002/bin.110
Bulkeley K, 2013, RES AUTISM SPECT DIS, V7, P1257, DOI 10.1016/j.rasd.2013.07.014
Carter S. L., 2005, J EARLY INTENSIVE BE, V2, P252
Case-Smith J, 1999, AM J OCCUP THER, V53, P489
Celiberti DA, 1997, RES DEV DISABIL, V18, P139, DOI 10.1016/S0891-4222(96)00032-7
Cox AL, 2009, FOCUS AUTISM DEV DIS, V24, P17, DOI 10.1177/1088357608330753
Cunningham AB, 2008, RES AUTISM SPECT DIS, V2, P469, DOI 10.1016/j.rasd.2007.09.006
Davis TN, 2013, DEV NEUROREHABIL, V16, P210, DOI 10.3109/17518423.2012.753955
Devlin S, 2011, J AUTISM DEV DISORD, V41, P1303, DOI 10.1007/s10803-010-1149-x
Fertel-Daly D, 2001, AM J OCCUP THER, V55, P629
Goldman S, 2009, DEV MED CHILD NEUROL, V51, P30, DOI 10.1111/j.1469-8749.2008.03178.x
Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
Hanley GP, 2003, J APPL BEHAV ANAL, V36, P147, DOI 10.1901/jaba.2003.36-147
Hodgetts S, 2011, J AUTISM DEV DISORD, V41, P805, DOI 10.1007/s10803-010-1104-x
HOEHN TP, 1994, J LEARN DISABIL, V27, P338
Iwata Brian A, 2008, Behav Anal Pract, V1, P3
Kane A, 2004, SCI REV MENTAL HLTH, V3, P19
Kennedy C, 2005, SINGLE CASE DESIGNS
KOEGEL RL, 1974, J APPL BEHAV ANAL, V7, P521, DOI 10.1901/jaba.1974.7-521
Kranowitz C. S., 2005, OUT OF SYNC CHILD
Lang R, 2012, RES AUTISM SPECT DIS, V6, P1004, DOI 10.1016/j.rasd.2012.01.006
Lang R, 2009, J APPL BEHAV ANAL, V42, P889, DOI 10.1901/jaba.2009.42-889
Lang R, 2010, RES AUTISM SPECT DIS, V4, P565, DOI 10.1016/j.rasd.2010.01.006
Lanovaz MJ, 2013, RES DEV DISABIL, V34, P2734, DOI [10.1016/j.ridd.2013.05.038, 10.1016/j.sidd.2013.05.038]
Lanovaz MJ, 2011, RES AUTISM SPECT DIS, V5, P1159, DOI 10.1016/j.rasd.2011.01.001
Lanovaz MJ, 2010, BEHAV INTERVENT, V25, P229, DOI 10.1002/bin.308
Leew SV, 2010, CAN J OCCUP THER, V77, P113, DOI 10.2182/cjot.2010.77.2.7
MacDonald R, 2007, RES DEV DISABIL, V28, P266, DOI 10.1016/j.ridd.2006.01.004
Matson J. L., 1995, USERS GUIDE QUESTION
Matson JL, 2007, RES DEV DISABIL, V28, P567, DOI 10.1016/j.ridd.2006.08.001
Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
Matson JL, 2012, RES DEV DISABIL, V33, P630, DOI 10.1016/j.ridd.2011.11.006
Morrison K, 1997, RES DEV DISABIL, V18, P127, DOI 10.1016/S0891-4222(96)00046-7
Mudford OC, 2009, J APPL BEHAV ANAL, V42, P527, DOI 10.1901/jaba.2009.42-527
Nuernberger JE, 2013, J DEV PHYS DISABIL, V25, P105, DOI 10.1007/s10882-012-9309-x
Olson Laurette J, 2004, Occup Ther Int, V11, P52, DOI 10.1002/oti.197
Olson Laurette J., 2004, Physical & Occupational Therapy in Pediatrics, V24, P45, DOI 10.1300/J006v24n03_04
Piazza CC, 2000, J APPL BEHAV ANAL, V33, P13, DOI 10.1901/jaba.2000.33-13
Prupas A, 2001, EDUC TRAIN MENT RET, V36, P196
Querim AC, 2013, J APPL BEHAV ANAL, V46, P47, DOI 10.1002/jaba.26
Quigley SP, 2011, RES AUTISM SPECT DIS, V5, P529, DOI 10.1016/j.rasd.2010.06.019
Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
Rapp JT, 2009, BEHAV INTERVENT, V24, P85, DOI 10.1002/bin.276
Reichow B, 2010, FOCUS AUTISM DEV DIS, V25, P3, DOI 10.1177/1088357609353751
Roscoe EM, 1998, J APPL BEHAV ANAL, V31, P635, DOI 10.1901/jaba.1998.31-635
Schreck KA, 2010, BEHAV INTERVENT, V25, P307, DOI 10.1002/bin.305
Schreck KA, 2008, BEHAV INTERVENT, V23, P201, DOI 10.1002/bin.264
Smith T, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P331
Taylor BA, 2005, BEHAV INTERVENT, V20, P239, DOI 10.1002/bin.200
VandenBerg NL, 2001, AM J OCCUP THER, V55, P621
Wallen Margaret, 2012, Aust Occup Ther J, V59, P468, DOI 10.1111/1440-1630.12014
Watkins N, 2014, J APPL BEHAV ANAL, V47, P186, DOI 10.1002/jaba.97
Watkins N, 2013, RES DEV DISABIL, V34, P11, DOI 10.1016/j.ridd.2012.08.003
Watling R, 1999, AM J OCCUP THER, V53, P498
Williamson G. G., 1997, ZERO 3, V17, P29
NR 69
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD MAY
PY 2014
VL 38
IS 3
SI SI
BP 412
EP 427
DI 10.1177/0145445514532128
PG 16
WC Psychology, Clinical
SC Psychology
GA AQ3GW
UT WOS:000342680400005
ER
PT J
AU Petrova, EG
Hyman, M
Estrella, MRP
Inglehart, MR
AF Petrova, Elena G.
Hyman, Michael
Estrella, Maria Regina Padilla
Inglehart, Marita R.
TI Children with Special Health Care Needs: Exploring the Relationships
between Patients' Level of Functioning, Their Oral Health, and
Caregivers' Oral Health-related Responses
SO PEDIATRIC DENTISTRY
LA English
DT Article
DE CHILDREN WITH DISABILITIES; ORAL HEALTH; HEALTH EDUCATION; PARENTS;
CHILDREN WITH SPECIAL HEALTH CARE NEEDS
ID SPECIAL OLYMPICS; BEHAVIOR; PERCEPTIONS; ATTITUDES; AUTISM
AB Purpose: The purposes of this study were to increase dentists' understanding of how to best engage parents and their children with special health care needs (SHCN) in oral health promotion efforts and explore the relationships between these patients' level of functioning. and oral health and their parents' comfort concerning oral health promotion. Methods: Survey data were collected from 154 caregivers of SHCN children. Children's oral health data were obtained from their clinical charts. Results: The patients' level of functioning ranged from the lowest to the highest regarding their ability to listen/understand, talk, relate to others, care for themselves, play with others, and participate in physical activities. Children's gingival health was correlated with their ability to talk (r=-.12; P<.05). Their oral hygiene score correlated with their ability to talk (r=.18; P<.05) and their skills in social play interactions (r=.21; P<.05). The parents' comfort level concerning oral health promotion correlated positively with their child's level of functioning. Parents' interest in receiving oral health instruction correlated positively with their child's level of functioning. Conclusions: Understanding patient's level of functioning might predict the degree to which parents actually engage in oral health promotion efforts and are interested in oral health-related education.
C1 [Petrova, Elena G.] Univ Minnesota, Sch Dent, Minneapolis, MN 55455 USA.
[Hyman, Michael] Wayne State Univ, Masters Program Biomed Sci, Detroit, MI USA.
[Inglehart, Marita R.] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA.
[Inglehart, Marita R.] Univ Michigan, Dept Psychol, Coll Literature Sci & Arts, Ann Arbor, MI USA.
[Estrella, Maria Regina Padilla] Univ Adelaide, Adelaide, SA, Australia.
[Estrella, Maria Regina Padilla] Womens & Childrens Hosp, Adelaide, SA, Australia.
RP Inglehart, MR (reprint author), Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA.
EM mri@umich.edu
CR Alhammad Nouf S, 2010, Odontostomatol Trop, V33, P5
American Academy of Pediatric Dentistry, 2013, PEDIAT DENT, V35, P157
[Anonymous], 2010, STAT PACK SOC SCI SP
Bakry NS, 2012, J CLIN PEDIATR DENT, V36, P319
Bissar AR, 2010, INT J PAEDIATR DENT, V20, P451, DOI 10.1111/j.1365-263X.2010.01065.x
Brown BR, 2011, ANGLE ORTHOD, V81, P1090, DOI 10.2319/013111-64.1
Dao Loan P, 2005, J Dent Educ, V69, P1107
Edelstein BL, 2009, ACAD PEDIATR, V9, P415, DOI 10.1016/j.acap.2009.09.010
Garfinkle AJ, 2010, J PERIODONTOL, V81, P1
Kenney MK, 2008, AMBUL PEDIATR, V8, P312, DOI 10.1016/j.ambp.2008.04.005
Kerins C, 2011, PEDIATR DENT, V33, P107
Kewallal A, PEDIAT DENT UNPUB
Leroy R, 2012, COMMUNITY DENT HLTH, V29, P68, DOI 10.1922/CDH_2704Leroy06
Mouradian W E, 2001, J Dent Educ, V65, P821
Nahar Sultana Gul, 2010, Bangladesh Med Res Counc Bull, V36, P61
National Maternal and Child Oral Health Resource Center, 2005, OR HLTH SERV CHILDR
Nelson LP, 2011, PEDIATR DENT, V33, P29
Oredugba Folakemi A, 2010, Spec Care Dentist, V30, P211, DOI 10.1111/j.1754-4505.2010.00155.x
Purohit Bharathi M, 2010, Spec Care Dentist, V30, P235, DOI 10.1111/j.1754-4505.2010.00160.x
Rich John P 3rd, 2006, J Dent Educ, V70, P1308
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Thikkurissy S, 2009, Dent Clin North Am, V53, P351, DOI 10.1016/j.cden.2008.12.004
U.S. Department of Health and Human Services, HIPAA ADM SIMPL STAT
US Department of Health and Human Services, 2000, NIH PUBL, V00-4713, P7
US Department of Health and Human Services Health Resources and Services Administration Maternal and Child Health Bureau, 2005, NAT SURV CHILDR HLTH
Van Dyck P, 2003, ARCH PEDIAT ADOLESC, V158, P884
Weil TN, 2010, J DENT EDUC, V74, P1294
Weil TN, 2012, PEDIATR DENT, V34, P473
NR 28
TC 0
Z9 0
PU AMER ACAD PEDIATRIC DENTISTRY
PI CHICAGO
PA 211 E CHICAGO AVENUE SUITE 1036, CHICAGO, IL 60611-2616 USA
SN 0164-1263
EI 1942-5473
J9 PEDIATR DENT
JI Pediatr. Dent.
PD MAY-JUN
PY 2014
VL 36
IS 3
BP 233
EP 239
PG 7
WC Dentistry, Oral Surgery & Medicine; Pediatrics
SC Dentistry, Oral Surgery & Medicine; Pediatrics
GA AP8NW
UT WOS:000342336700011
PM 24960391
ER
PT J
AU Papineau, SD
Wilson, S
AF Papineau, Scott D.
Wilson, Stephen
TI Dentition Abnormalities in a Timothy Syndrome Patient With a Novel
Genetic Mutation: A Case Report
SO PEDIATRIC DENTISTRY
LA English
DT Article
DE TIMOTHY SYNDROME; ENAMEL HYPOPLASIA; GENETICS
ID LONG QT SYNDROME; ARRHYTHMIA
AB The purpose of this paper was to present the case of a two-year-old male diagnosed with Timothy syndrome who presented with generalized enamel defects in the primary dentition. Timothy syndrome is an autosomal dominant condition characterized by a de novo missense mutation in the Ca(v)1.2 L-type calcium channel CACNA1C. Timothy syndrome patients present with multiple clinical manifestations, including: cardiac arrhythmias; syndactyly; immune deficiency; intermittent hypoglycemia; and neurologic issues, including seizures, mental retardation, hypotonia, and autism. Craniofacial abnormalities reported include: low-set ears; flat nasal bridge; small upper jaw; thin upper lip; round face; and baldness at birth. Abnormalities in the dentition have been reported, including small, misplaced teeth with poor enamel and severe caries. At present, there is no thorough description of the dental abnormalities seen in a patient with Timothy syndrome.
C1 [Wilson, Stephen] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Dent, Cincinnati, OH 45229 USA.
EM scott.papineau@yahoo.com
CR Czosek RJ, 2010, HEART RHYTHM, V7, P1516, DOI 10.1016/j.hrthm.2010.05.023
Etheridge SP, 2011, AM J MED GENET A, V155A, P2578, DOI 10.1002/ajmg.a.34223
Gillis J, 2012, AM J MED GENET A, V158A, P182, DOI 10.1002/ajmg.a.34355
Krause U, 2011, CLIN RES CARDIOL, V100, P1123, DOI 10.1007/s00392-011-0358-4
Lo-A-Njoe SM, 2005, HEART RHYTHM, V2, P1369
MARKS ML, 1995, J AM COLL CARDIOL, V25, P59, DOI 10.1016/0735-1097(94)00318-K
MARKS ML, 1995, AM J CARDIOL, V76, P744, DOI 10.1016/S0002-9149(99)80216-1
Splawski I, 2005, P NATL ACAD SCI USA, V102, P8089, DOI 10.1073/pnas.0502506102
Splawski I, 2006, GENE REV
Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
Yarotskyy V, 2009, J PHYSIOL-LONDON, V587, P551, DOI 10.1113/jphysiol.2008.161737
NR 11
TC 0
Z9 0
PU AMER ACAD PEDIATRIC DENTISTRY
PI CHICAGO
PA 211 E CHICAGO AVENUE SUITE 1036, CHICAGO, IL 60611-2616 USA
SN 0164-1263
EI 1942-5473
J9 PEDIATR DENT
JI Pediatr. Dent.
PD MAY-JUN
PY 2014
VL 36
IS 3
BP 245
EP 249
PG 5
WC Dentistry, Oral Surgery & Medicine; Pediatrics
SC Dentistry, Oral Surgery & Medicine; Pediatrics
GA AP8NW
UT WOS:000342336700013
PM 24960393
ER
PT J
AU Kaurani, L
Vishal, M
Kumar, D
Sharma, A
Mehani, B
Sharma, C
Chakraborty, S
Jha, P
Ray, J
Sen, A
Dash, D
Ray, K
Mukhopadhyay, A
AF Kaurani, Lalit
Vishal, Mansi
Kumar, Dhirendra
Sharma, Anchal
Mehani, Bharati
Sharma, Charu
Chakraborty, Subhadip
Jha, Pankaj
Ray, Jharna
Sen, Abhijit
Dash, Debasis
Ray, Kunal
Mukhopadhyay, Arijit
TI Gene-Rich Large Deletions Are Overrepresented in POAG Patients of Indian
and Caucasian Origins
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE glaucoma; POAG; genomics; CNV; CNTN4
ID COPY-NUMBER VARIATION; OPEN-ANGLE GLAUCOMA; CHROMOSOME 3Q; REVEALS;
SUSCEPTIBILITY; DUPLICATIONS; POPULATIONS; PHENOTYPES; VARIANTS;
SPECTRUM
AB PURPOSE. Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness.
METHODS. Genome-wide analysis of CNVs > 100 kb were analyzed in a total of 1720 individuals, including an Indian cohort (347 POAG cases and 345 controls) and a Caucasian cohort (624 cases and 404 controls). All the CNV data were obtained from experiments performed on Illumina 660W-Quad (infinium) arrays.
RESULTS. We observed that for both the populations CNVs > 1 Mb was significantly enriched for gene-rich regions unique to the POAG cases (P < 10 (11)). In the Indian cohort CNVs > 1 Mb (39 calls) in patients influenced 125 genes while in controls 31 such CNVs influenced only 5 genes with no overlap. In both cohorts we observed 1.9-fold gene enrichment in patients for deletions compared to duplications, while such a bias was not observed in controls (0.3-fold). Overall duplications > 1 Mb were more than deletions (Del/Dup = 0.82) confirming that the enrichment of gene-rich deletions in patients was associated with the disease. Of the 39 CNVs > 1 Mb from Indian patients, 28 (72%) also were implicated in other neurodegenerative disorders, like autism, schizophrenia, sensorineural hearing loss, and so forth. We found one large duplication encompassing CNTN4 gene in Indian and Caucasian POAG patients that was absent in the controls.
CONCLUSIONS. To our knowledge, our study is the first report on large CNV bias for gene-rich regions in glaucomatous neurodegeneration, implicating its impact across populations of contrasting ethnicities. We identified CNTN4 as a novel candidate gene for POAG.
C1 [Kaurani, Lalit; Vishal, Mansi; Sharma, Anchal; Mehani, Bharati; Jha, Pankaj; Mukhopadhyay, Arijit] CSIR Inst Genom & Integrat Biol, Delhi, India.
[Vishal, Mansi; Chakraborty, Subhadip; Ray, Kunal] CSIR Indian Inst Chem Biol, Mol & Human Genet Div, Kolkata, India.
[Kumar, Dhirendra; Dash, Debasis] CSIR Inst Genom & Integrat Biol, GN Ramachandran Knowledge Ctr Genome Informat, Delhi, India.
[Sharma, Anchal; Ray, Kunal; Mukhopadhyay, Arijit] Acad Sci & Innovat Res AcSIR, New Delhi, India.
[Sharma, Charu] Shiv Nadar Univ, Dept Math, Gautam Buddha Nagar, Uttar Pradesh, India.
[Chakraborty, Subhadip; Ray, Jharna] Univ Calcutta, SN Pradhan Ctr Neurosci, Kolkata, India.
[Sen, Abhijit] Dristi Pradip, Kolkata, India.
RP Mukhopadhyay, A (reprint author), CSIR Cent Rd Res Inst, Acad Sci & Innovat Res, CSIR Inst Genom & Integrat Biol IGIB, Mathura Rd Near Sukhdev Vihar, New Delhi 110025, India.
EM kunalray@gmail.com; arijit@igib.res.in
FU Council of Scientific and Industrial Research (CSIR), India [MLP-0016,
BSC-0123]; CSIR-India; National Institutes of Health (NIH) Genes,
Environment and Health Initiative [GEI] [U01HG004728]; Gene Environment
Association Studies (GENEVA) under GEI; NIH GEI [U01 HG04424]
FX Supported by the Council of Scientific and Industrial Research (CSIR),
India (Grants MLP-0016 and BSC-0123), and a senior research fellowship
from CSIR-India (LK). The GLAUGEN study was supported by the National
Institutes of Health (NIH) Genes, Environment and Health Initiative
([GEI], U01HG004728). The GLAUGEN study is one of the genome-wide
association studies funded as part of the Gene Environment Association
Studies (GENEVA) under GEI. Genotyping, which was performed at the Broad
Institute of the Massachusetts Institute of technology (MIT; Cambridge,
MA, USA) and Harvard University (Cambridge, MA, USA), was supported by
the NIH GEI (U01 HG04424).
CR Banerjee D, 2012, MOL VIS, V18, P1548
Burdon KP, 2011, NAT GENET, V43, P574, DOI 10.1038/ng.824
Chanda B, 2008, HUM MOL GENET, V17, P3446, DOI 10.1093/hmg/ddn238
Chen R, 2012, CELL, V148, P1293, DOI 10.1016/j.cell.2012.02.009
Davis LK, 2011, INVEST OPHTH VIS SCI, V52, P7122, DOI 10.1167/iovs.10-5606
Fernandez T, 2004, AM J HUM GENET, V74, P1286, DOI 10.1086/421474
Fingert JH, 2011, HUM MOL GENET, V20, P2482, DOI 10.1093/hmg/ddr123
Fu WQ, 2013, NATURE, V493, P216, DOI 10.1038/nature11690
Gautam P, 2012, HUM GENET, V131, P131, DOI 10.1007/s00439-011-1050-5
Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Gonzalez E, 2005, SCIENCE, V307, P1434, DOI 10.1126/science.1101160
Hansford LM, 2003, CYTOGENET GENOME RES, V101, P17, DOI 10.1159/000073412
Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
Jakobsson M, 2008, NATURE, V451, P998, DOI 10.1038/nature06742
Kitsos G, 2001, EUR J HUM GENET, V9, P452, DOI 10.1038/sj.ejhg.5200645
Kuningas M, 2011, HUM MOL GENET, V20, P4290, DOI 10.1093/hmg/ddr340
Lehmann OJ, 2002, INVEST OPHTH VIS SCI, V43, P1843
Liu YT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027134
Nag A, 2013, INVEST OPHTH VIS SCI, V54, P3607, DOI 10.1167/iovs.13-11952
Prasov L, 2012, HUM MOL GENET, V21, P3681, DOI 10.1093/hmg/dds197
Ray K, 2009, J GENET, V88, P451
Rzhetsky A, 2007, P NATL ACAD SCI USA, V104, P11694, DOI 10.1073/pnas.0704820104
Scheetz TE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058657
Tanaka E, 2008, J NEUROL SCI, V266, P180, DOI 10.1016/j.jns.2007.09.004
Tsuang DW, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014456
Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
Wirtz MK, 1997, AM J HUM GENET, V60, P296
Yamagata M, 2012, J NEUROSCI, V32, P14402, DOI 10.1523/JNEUROSCI.3193-12.2012
NR 29
TC 1
Z9 1
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAY
PY 2014
VL 55
IS 5
BP 3258
EP 3264
DI 10.1167/iovs.14-14339
PG 7
WC Ophthalmology
SC Ophthalmology
GA AL9TP
UT WOS:000339484800058
PM 24764060
ER
PT J
AU Dodd, JL
Hagge, DK
AF Dodd, Janet L.
Hagge, Darla K.
TI AAC Camp as an Alternative School-Based Service Delivery Model: A
Retrospective Survey
SO COMMUNICATION DISORDERS QUARTERLY
LA English
DT Article
DE AAC intervention; progress monitoring; complex communication needs;
alternative service delivery model
ID COMPLEX COMMUNICATION NEEDS; AIDED LANGUAGE STIMULATION;
DEVELOPMENTAL-DISABILITIES; SPEECH PRODUCTION; CHILDREN; INTERVENTIONS;
ADULTS; INDIVIDUALS; AUTISM; IMPACT
AB School-based speech-language pathologists are obligated to apply evidence-based practice and document progress of their students' response to intervention in compliance with federal law. The purpose of this preliminary study was to explore the effects of an augmentative and alternative communication (AAC)-based intervention provided in a camp format and begin the exploration of examining strategies to monitor and document progress. Through the use of a survey, data were also collected regarding the demographics of camp attendees and their response to the camp-based intervention model. Results indicated children with autism and intellectual disability comprised a significant portion of the children referred for this type of intervention, and positive gains were documented both in the areas of communicative behaviors and pragmatic use.
C1 [Dodd, Janet L.] Chapman Univ, Orange, CA 92866 USA.
[Hagge, Darla K.] Calif State Univ Sacramento, Sacramento, CA 95819 USA.
RP Dodd, JL (reprint author), Chapman Univ, 1 Univ, Orange, CA 92866 USA.
EM doddkidtalk@verizon.net
CR Alant E, 2006, DISABIL REHABIL, V28, P143, DOI 10.1080/09638280500077986
American Speech-Language-Hearing Association, 2005, ROL RESP SPEECH LANG
[Anonymous], 2004, S C
Beck AR, 2009, AUGMENT ALTERN COMM, V25, P42, DOI 10.1080/07434610802131059
Beukelman DR, 2008, AUGMENT ALTERN COMM, V24, P255, DOI 10.1080/07434610802388477
Binger Cathy, 2008, Seminars in Speech and Language, V29, P101, DOI 10.1055/s-2008-1079124
Binger C, 2007, AUGMENT ALTERN COMM, V23, P30, DOI 10.1080/07434610600807470
Binger C, 2011, J SPEECH LANG HEAR R, V54, P160, DOI 10.1044/1092-4388(2010/09-0163)
Bruner J, 1981, LANG COMMUN, V1, P155, DOI DOI 10.1016/0271-5309(81)90010-0
Bruno J, 2006, AUGMENT ALTERN COMM, V22, P300, DOI 10.1080/07434610600768318
Calculator S. N., 1999, AUGMENTATIVE ALTERNA, V15, P4, DOI 10.1080/07434619912331278525
Dada S, 2009, AM J SPEECH-LANG PAT, V18, P50, DOI 10.1044/1058-0360(2008/07-0018)
Dodd J. L., 2011, AM SPEECH LANG HEAR
Dodd J. L., 2013, IMMERSIVE AAC UNPUB
Dyches T. T., 2002, AUGMENTATIVE ALTERNA, V18, P124, DOI 10.1080/07434610212331281211
Ganz JB, 2012, J AUTISM DEV DISORD, V42, P60, DOI 10.1007/s10803-011-1212-2
Goossens C., 1989, AUGMENTATIVE ALTERNA, V5, P14, DOI 10.1080/07434618912331274926
Gorey M., 2013, CAL SPEECH LANG HEAR
Grant S., 1995, J CHILDHOOD COMMUNIC, V16, P31
Harris MD, 2004, AM J SPEECH-LANG PAT, V13, P155, DOI 10.1044/1058-0360(2004/016)
Hemsley B, 2008, AUGMENT ALTERN COMM, V24, P110, DOI 10.1080/07434610701830579
Larsson M, 2008, AUGMENT ALTERN COMM, V24, P139, DOI 10.1080/07434610801897239
Light J., 1989, AUGMENTATIVE ALTERNA, V5, P137, DOI 10.1080/07434618912331275126
Light J., 1997, AUGMENTATIVE ALTERNA, V13, P61, DOI 10.1080/07434619712331277848
Lund SK, 2003, J SPEECH LANG HEAR R, V46, P1110, DOI 10.1044/1092-4388(2003/087)
Mancil GR, 2006, EDUC TRAIN DEV DISAB, V41, P213
Millar DC, 2006, J SPEECH LANG HEAR R, V49, P248, DOI 10.1044/1092-4388(2006/021)
Mirenda P., 2013, AUGMENTATIVE ALTERNA, V4th
National Joint Committee for the Communication Needs of Persons With Severe Disabilities, 1992, ASHA S7, V34, P2
Nigam R, 2006, AUGMENT ALTERN COMM, V22, P160, DOI 10.1080/07434610600650052
Paul R, 2012, LANGUAGE DISORDERS I
Schlosser R. W., 2004, AUGMENTATIVE ALTERNA, V20, P1, DOI 10.1080/07434610310001621083
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
Schlosser RW, 2006, RES DEV DISABIL, V27, P1, DOI 10.1016/j.ridd.2004.04.004
Schlosser RW, 2005, AUGMENT ALTERN COMM, V21, P233, DOI 10.1080/07434610500194813
Shumway S, 2009, J SPEECH LANG HEAR R, V52, P1139, DOI 10.1044/1092-4388(2009/07-0280)
Sigafoos J., 2005, TECHNOLOGY DISABILIT, V17, P143
Ukrainetz T., 2008, AM SPEECH LANG HEAR
van der Meer L, 2012, RES DEV DISABIL, V33, P1658, DOI 10.1016/j.ridd.2012.04.004
Warren SF, 2007, MENT RETARD DEV D R, V13, P70, DOI 10.1002/mrdd.20139
WETHERBY AM, 1988, J SPEECH HEAR RES, V31, P240
Wetherby A. M., 1989, SEMINARS SPEECH LANG, V10, P77, DOI 10.1055/s-0028-1082491
NR 42
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1525-7401
EI 1538-4837
J9 COMMUN DISORD Q
JI Comm. Disord. Q.
PD MAY
PY 2014
VL 35
IS 3
BP 123
EP 132
DI 10.1177/1525740113512670
PG 10
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA AL7SP
UT WOS:000339335800001
ER
PT J
AU DeVeney, SL
Cress, CJ
Reid, R
AF DeVeney, Shari L.
Cress, Cynthia J.
Reid, Robert
TI Comparison of Two Word Learning Techniques and the Effect of
Neighborhood Density for Late Talkers
SO COMMUNICATION DISORDERS QUARTERLY
LA English
DT Article
DE birth to 3 years; age; intervention strategies; language/linguistics;
delays/disorders; research; single subject; methodology; research
ID LATE-TALKING TODDLERS; LANGUAGE IMPAIRMENT; PHONOTACTIC PROBABILITY;
READING OUTCOMES; VOCABULARY; ACTIVATION; AUTISM; DELAYS
AB The investigators compared two techniques for teaching expressive vocabulary to late talkers: modeling with an expectant pause and modeling with an evoked child production. They also explored the influence of neighborhood density on children's real word learning. Three late talkers (ages 25-33 months) received two alternating vocabulary treatments (expectant pause and evoked production) in the home. Two participants were identified as having an expressive language delay, and one participant was identified as having an expressive and receptive language delay. During the expectant pause treatment, the clinician paused several seconds after each target word model, looking at the child expectantly. In the evoked production condition, after each target word model, a child was prompted to say the word using a cloze procedure of the modeled phrase. Both treatments were effective for all participants; no consistent advantage of one treatment technique over the other was noted. Two participants produced denser words than sparse words, one in early sessions and one in later experimental sessions, but a consistent pattern was not present across all participants. This study provided support for focused vocabulary intervention with late talking toddlers. Receptive language skills and word form characteristics may help explain individual variations in response to treatment for late talkers.
C1 [DeVeney, Shari L.] Univ Nebraska Omaha, Omaha, NE 68182 USA.
[Cress, Cynthia J.; Reid, Robert] Univ Nebraska Lincoln, Lincoln, NE USA.
RP DeVeney, SL (reprint author), Univ Nebraska Omaha, Dept Special Educ & Commun Disorders, 6005 Dodge St,512E Roskens Hall, Omaha, NE 68182 USA.
EM sdeveney@unomaha.edu
CR Cable A. L., 2010, INT J LANG COMM DIS, V46, P138
Desmarais C, 2008, INT J LANG COMM DIS, V43, P361, DOI 10.1080/13682820701546854
Drager KDR, 2006, AM J SPEECH-LANG PAT, V15, P112, DOI 10.1044/1058-0360(2006/012)
Fenson L., 2006, MACARTHUR BATES COMM
Fey M., 1986, LANGUAGE INTERVENTIO
Girolametto L, 1996, J SPEECH HEAR RES, V39, P1274
Girolametto L. E., 1996, J CHILDHOOD COMMUNIC, V17, P39
Hancock TB, 2006, TREATMENT LANGUAGE D, P203
Hoover JR, 2012, J CHILD LANG, V39, P835, DOI 10.1017/S0305000911000365
Hoover JR, 2010, J MEM LANG, V63, P100, DOI 10.1016/j.jml.2010.02.003
Kouri TA, 2005, J SPEECH LANG HEAR R, V48, P157, DOI 10.1044/1092-4388(2004/012)
Lederer S. H., 2001, INFANT TODDLER INTER, V11, P223
LEONARD LB, 1982, J SPEECH HEAR RES, V25, P554
Luce PA, 1998, EAR HEARING, V19, P1, DOI 10.1097/00003446-199802000-00001
MacRoy-Higgins M., 2012, INT J LANG COMM DIS, V48, P188
WEISMER SE, 1989, J SPEECH HEAR DISORD, V54, P269
Nelson J. R., 1999, RES METHODS
Newborg J, 2005, BATTELLE DEV INVENTO
Rescorla L, 2005, J SPEECH LANG HEAR R, V48, P459, DOI 10.1044/1092-4388(2005/031)
Rescorla L, 2002, J SPEECH LANG HEAR R, V45, P360, DOI 10.1044/1092-4388(2002/028)
Rescorla L, 2009, J SPEECH LANG HEAR R, V52, P16, DOI 10.1044/1092-4388(2008/07-0171)
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Shriberg LD, 1997, J SPEECH LANG HEAR R, V40, P708
Storkel HL, 2010, J COMMUN DISORD, V43, P105, DOI 10.1016/j.jcomdis.2009.11.001
Storkel HL, 2009, J CHILD LANG, V36, P291, DOI 10.1017/S030500090800891X
Storkel HL, 2010, BEHAV RES METHODS, V42, P497, DOI 10.3758/BRM.42.2.497
Storkel HL, 2006, J SPEECH LANG HEAR R, V49, P1175, DOI 10.1044/1092-4388(2006/085)
Thomson JM, 2005, MEM COGNITION, V33, P1210, DOI 10.3758/BF03193223
Tsybina I, 2007, CONT ISSUES COMMUNIC, V34, P118
Vannest K., 2009, BEHAV THER, V40, P357
Vannest K. J., 2011, SINGLE CASE RES WEB
Vitevitch MS, 1999, J MEM LANG, V40, P374, DOI 10.1006/jmla.1998.2618
WEISMER SE, 1993, J SPEECH HEAR RES, V36, P1037
Wilcox M. J., 1991, AM J SPEECH-LANG PAT, V1, P49
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 35
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1525-7401
EI 1538-4837
J9 COMMUN DISORD Q
JI Comm. Disord. Q.
PD MAY
PY 2014
VL 35
IS 3
BP 133
EP 145
DI 10.1177/1525740113516788
PG 13
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA AL7SP
UT WOS:000339335800002
ER
PT J
AU Allely, CS
Minnis, H
Thompson, L
Wilson, P
Gillberg, C
AF Allely, Clare S.
Minnis, Helen
Thompson, Lucy
Wilson, Philip
Gillberg, Christopher
TI Neurodevelopmental and psychosocial risk factors in serial killers and
mass murderers
SO AGGRESSION AND VIOLENT BEHAVIOR
LA English
DT Article
DE Autistic Spectrum Disorder; Serial killer; Mass murder; Brain injury;
Psychosocial stressors
ID ASPERGERS-SYNDROME; SEXUAL HOMICIDE; ANTISOCIAL-BEHAVIOR; CRIMINAL
BEHAVIOR; UNITED-STATES; HEAD-INJURY; VIOLENCE; AGGRESSION;
DAHMER,JEFFREY; PSYCHOPATHY
AB Multiple and serial murders are rare events that have a very profound societal impact. We have conducted a systematic review, following PRISMA guidelines, of both the peer reviewed literature and of journalistic and legal sources regarding mass and serial killings. Our findings tentatively indicate that these extreme forms of violence may be a result of a highly complex interaction of biological, psychological and sociological factors and that, potentially, a significant proportion of mass or serial killers may have had neurodevelopmental disorders such as autism spectrum disorder or head injury. Research into multiple and serial murders is in its infancy: there is a lack of rigorous studies and most of the literature is anecdotal and speculative. Specific future study of the potential role of neurodevelopmental disorders in multiple and serial murders is warranted and, due to the rarity of these events, innovative research techniques may be required. (C) 2014 The Authors. Published by Elsevier Ltd.
C1 [Allely, Clare S.; Minnis, Helen; Thompson, Lucy] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G3 8SJ, Lanark, Scotland.
[Wilson, Philip] Univ Aberdeen, Ctr Rural Hlth, Ctr Hlth Sci, Inverness IV2 3JH, Scotland.
[Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
RP Minnis, H (reprint author), Univ Glasgow, Inst Hlth & Wellbeing, Royal Hosp Sick Children, Caledonia House,Yorkhill, Glasgow G3 8SJ, Lanark, Scotland.
EM Clare.allely@glasgow.ac.uk; Helen.minnis@glasgow.ac.uk;
Lucy.thompson@glasgow.ac.uk; p.wilson@abdn.ac.uk;
christopher.gillberg@gnc.gu.se
CR Allen D, 2008, J AUTISM DEV DISORD, V38, P748, DOI 10.1007/s10803-007-0442-9
American Psychiatriac Association, 2000, DIAGN STAT MAN MEN, VFourth
Arrigo BA, 2004, BEHAV SCI LAW, V22, P375, DOI 10.1002/bsl.583
BARONCOHEN S, 1988, J CHILD PSYCHOL PSYC, V29, P351, DOI 10.1111/j.1469-7610.1988.tb00723.x
Baron-Cohen Simon, 2011, SCI EVIL EMPATHY ORI
Barry-Walsh JB, 2004, J FORENSIC PSYCHI PS, V15, P96, DOI 10.1080/14789940310001638628
Barzman DH, 2010, NEUROPSYCH DIS TREAT, V6, P691, DOI 10.2147/NDT.S5832
Beasley JO, 2004, BEHAV SCI LAW, V22, P395, DOI 10.1002/bsl.595
Beaver K. M., 2014, EVOLUTIONARY BEHAV G, P117
Bell C, 2001, BRIT J PSYCHIAT, V178, P399, DOI 10.1192/bjp.178.5.399
BENNETT KA, 1993, J FORENSIC SCI, V38, P1227
Brantley A. G., 2005, FBI LAW ENFORCEMENT, V74, P26
BRITTAIN RP, 1970, MED SCI LAW, V10, P198
Browning A, 2011, CRIMINOL CRIM JUSTIC, V11, P165, DOI 10.1177/1748895811398455
Burgess A. W., 1994, SERIAL MURDER HDB AG, P509
Buss DM, 1997, CLIN PSYCHOL REV, V17, P605, DOI 10.1016/S0272-7358(97)00037-8
Campobasso CP, 2009, FORENSIC SCI INT, V185, P7, DOI 10.1016/j.forsciint.2008.12.023
Cantor CH, 2000, J AM ACAD PSYCHIATRY, V28, P55
Carlin N., 2011, PASTORAL PSYCHOL, V60, DOI 10.1007/s11089-011-0348-5
Carlisle A. C., 2000, SERIAL KILLERS
Carlo P., 1996, NIGHT STALKER TRUE S
Cervantes SV, 2010, CRIME MEDIA CULT, V6, P185, DOI 10.1177/1741659010378630
Claus C, 1999, J FORENSIC PSYCHIATR, V10, P427, DOI 10.1080/09585189908403694
CLONINGER CR, 1982, ARCH GEN PSYCHIAT, V39, P1242
COOPER SA, 1993, J INTELL DISABIL RES, V37, P189
Cullen, 1996, CULLEN PUBLIC INQUIR
Dahmer L., 1994, FATHERS STORY
Davis C. A., 2007, SADISTIC KILLERS PRO
Davis D., 1991, NIGHTMARE APARTMENT
de Becker G., 1997, GIFT FEAR
DEHART DD, 1994, OMEGA-J DEATH DYING, V29, P29
Dein K., 2010, ADV PSYCHIAT TREATME, V16, P37
DIETZ PE, 1986, B NEW YORK ACAD MED, V62, P477
Dutton D., 1992, INT J OFFENDER THER, V36, P212
Duwe G, 2004, JUSTICE Q, V21, P729, DOI 10.1080/07418820400095971
Dvorchak B., 1991, MILWAKEE MASSACRE J
Eftimiades M., 1993, GARDEN GRAVES SHOCKI
Egger S. A., 1998, J DAHMER KILLER US E
EGGER SA, 1984, J POLICE SCI ADMIN, V12, P348
EVERALL IP, 1990, BRIT J PSYCHIAT, V157, P284, DOI 10.1192/bjp.157.2.284
Fanning D., 2007, WINDOW TERRIFYING TR
Ferguson CJ, 2003, J CRIM JUST, V31, P287, DOI 10.1016/S0047-2352(03)00009-6
Fitzgerald M, 2010, PSYCHIAT THEOR APPL, P1
Fitzgerald M, 2001, J AM ACAD CHILD PSY, V40, P870, DOI 10.1097/00004583-200108000-00006
Fox J. A., 2007, BRIFF TREATMENT CRIS, V7, P127, DOI 10.1093/brief-treatment/mhm005
Fox J. A., 2005, EXTREME KILLING UNDE
Fox J. A., 1994, OVERKILL MASS MURDER
Fox JA, 1998, CRIME JUSTICE, V23, P407, DOI 10.1086/449274
Freckelton I., 2012, COMPREHENSIVE BOOK A, P249
Freedman D, 2000, SOC SCI MED, V50, P1757, DOI 10.1016/S0277-9536(99)00417-7
Gansler DA, 2009, PSYCHIAT RES-NEUROIM, V171, P145, DOI 10.1016/j.pscychresns.2008.03.007
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
Goetz AT, 2010, PSICOTHEMA, V22, P15
Grafman J, 1996, NEUROLOGY, V46, P1231
Hagelstam C, 2006, FORENSIC SCI INT, V164, P110, DOI 10.1016/j.forsciint.2005.12.006
HALE R, 1994, PSYCHOLOGY, V31, P17
HALL I, 1995, BRIT J PSYCHIAT, V166, P262
Heide KM, 2006, INT J LAW PSYCHIAT, V29, P220, DOI 10.1016/j.ijlp.2005.10.001
Hickey E, 1997, SERIAL MURDERS THEIR
Hippler K, 2010, J AUTISM DEV DISORD, V40, P774, DOI 10.1007/s10803-009-0917-y
Holmes R. M., 2010, SERIAL MURDER, V3rd
Hyland P., 2012, INT J CRIMINOL SOCIO, V5, P864
Inguito G B, 2000, Del Med J, V72, P479
Jenkins P., 2005, THEMYTHOLOGY CRIME C
JENTZEN J, 1994, AM J FOREN MED PATH, V15, P283, DOI 10.1097/00000433-199412000-00002
Kelleher MD, 1997, FLASH POINT AM MASS
Kennedy D., 1994, KILLING DAY BIZARRE
Kiger K., 1990, SERIAL MURDER ELUSIV, P35
Kirschner D, 1996, INT J OFFENDER THER, V40, P204, DOI 10.1177/0306624X9604000304
Kohn Y, 1998, ISRAEL J PSYCHIAT, V35, P293
KON Y, 1994, BRIT J PSYCHIAT, V165, P685, DOI 10.1192/bjp.165.5.685
LaBrode R. T., 2007, BRIEF TREATMENT CRIS, V7, P151, DOI DOI 10.1093/BRIEF-TREATMENT/MHM004
Lachmann FM, 2006, PSYCHOANAL INQ, V26, P362
LaFree G., 1999, HOMICIDE SOURCEBOOK, P125
LaFree G., 1999, STUDYING PREVENTING, Vvi, P79
Langevin R., 1988, ANN SEX RES, V1, P263, DOI 10.1007/BF00852801
Langman P, 2009, AGGRESS VIOLENT BEH, V14, P79, DOI 10.1016/j.avb.2008.10.003
Lee J, 2007, ANN ACAD MED SINGAP, V36, P444
Lewis D. O., 1998, GUILTY REASON INSANI
Lundstrom S., 2013, J AUTISM DEV DISORD, P1
Luxenburg J., 1993, ANN M AM SOC CRIM MI
Martens Willem H J, 2011, Psychoanal Rev, V98, P493, DOI 10.1521/prev.2011.98.4.493
Martens WHJ, 2005, INT J OFFENDER THER, V49, P298, DOI 10.1177/0306624X05274898
Maseide, 2012, LANCET, V379, P2413
Masters B., 1993, SHRINE J DAHMER
MAWSON D, 1985, BRIT J PSYCHIAT, V147, P566, DOI 10.1192/bjp.147.5.566
Meloy JR, 2000, AGGRESS VIOLENT BEH, V5, P1, DOI 10.1016/S1359-1789(99)00006-3
Mesibov GB, 2006, AUTISM, V10, P7, DOI 10.1177/136236130601000102
Miller L, 2000, SERIAL OFFENDERS : CURRENT THOUGHT, RECENT FINDINGS, P135
Mitchell H., 2005, J POLICE CRIMINAL PS, V20, P40, DOI 10.1007/BF02806705
Mladinch R, 2001, J RIFKIN STORY MOUTH
Moes E. C., 1991, M KLEIN OBJECT RELAT, V9, P54
Mouridsen SE, 2008, INT J OFFENDER THER, V52, P196, DOI 10.1177/0306624X07302056
Mouzos J., 2007, TRENDS ISSUES CRIME, V346
Mukaddes NM, 2006, J AUTISM DEV DISORD, V36, P471, DOI 10.1007/s10803-006-0087-0
Murphy D, 2010, J FORENSIC PSYCHI PS, V21, P462, DOI 10.1080/14789940903426885
Myers W. C., 2008, FORENSIC SCI INT, V176, P87
Myers W C, 1993, Bull Am Acad Psychiatry Law, V21, P435
Myers WC, 2005, J FORENSIC SCI, V50, P652
Myers WC, 2004, BEHAV SCI LAW, V22, P357, DOI 10.1002/bsl.590
Newman G., 1977, ABSTRACTS CRIMINOLOG, V17, P251
Nichols DS, 2006, J PERS ASSESS, V86, P242, DOI 10.1207/s15327752jpa8603_02
Norris J, 1988, SERIAL KILLERS
Ostrosky-Solis F, 2008, J FORENSIC SCI, V53, P1223, DOI 10.1111/j.1556-4029.2008.00803.x
Palermo GB, 2008, SERIAL MURDER AND THE PSYCHOLOGY OF VIOLENT CRIMES, P85, DOI 10.1007/978-1-60327-049-6_6
PALLONE NJ, 1998, SOCIETY, V35
POLLOCK PH, 1995, INT J OFFENDER THER, V39, P258, DOI 10.1177/0306624X9503900306
Prenky B. L., 1989, AM J PSYCHIAT, V146, P887
Prothero M., 2007, DEFENDING GRAY UNRAV
Pulitzer L.B., 1994, CROSSING LINE TRUE S
Quinet K, 2007, HOMICIDE STUD, V11, P319, DOI 10.1177/1088767907307467
Raine A., 1995, NEUROPSYCHIATRY PERS, P50
Raine A, 1993, PSYCHOPATHOLOGY CRIM
Raine A, 2008, CURR DIR PSYCHOL SCI, V17, P323, DOI 10.1111/j.1467-8721.2008.00599.x
Ramsland K., 2011, MIND MURDERER PRIVIL, pxiii
Ressler B. K., 1992, WHOEVER FIGHTS MONST
Ressler R. K., 1988, SEXUAL HOMICIDE PATT
Sale I, 2008, SERIAL MURDER AND THE PSYCHOLOGY OF VIOLENT CRIMES, P197, DOI 10.1007/978-1-60327-049-6_11
Salfati G. C., 2001, HOMICIDE STUDIES, V5, P286
Sarapatta M, 1998, BRAIN INJURY, V12, P821, DOI 10.1080/026990598122061
Schlesinger LB, 2000, SERIAL OFFENDERS : CURRENT THOUGHT, RECENT FINDINGS, P3
Schlesinger LB, 1998, CURR PSYCHOL, V17, P212, DOI 10.1007/s12144-998-1007-6
Scott J, 1996, BRIT MED J, V312, P2
SCRAGG P, 1994, BRIT J PSYCHIAT, V165, P679, DOI 10.1192/bjp.165.5.679
Sederstrom H., 2001, J NEURAL TRANSM, V108, P869
Silva J. A., 2003, AM J FORENSIC PSYCH, V24, P5
Silva J. A., 2002, AM ACAD PSYCHIAT LAW
Silva J. A., 2005, AM J FORENSIC PSYCH, V26, p[2005, 25]
Silva J. A., 2003, AM ACAD PSYCHIAT LAW
Silva J. A., 2002, P AM ACAD FORENSIC S, VVIII
Silva J. A., 2003, P AM ACAD FORENSIC S, VIX
Silva JA, 2002, J FORENSIC SCI, V47, P1347
Silva JA, 2004, BEHAV SCI LAW, V22, P787, DOI 10.1002/bsl.620
Silvio H, 2006, J CRIM JUST, V34, P251, DOI 10.1016/j.jcrimjus.2006.03.006
Smith K., 2012, HOMICIDES FIREARM OF
Soderstrom A. H., 2005, NORD J PSYCHIAT, V59, P246
Sperber M., 2010, DOSTOYEVSKYS STALKER
Stein A, 2004, CONTEMP PSYCHOANAL, V40, P495
Stone M. H., 2009, THE ANATOMY OF EVIL
STONE MH, 1989, PSYCHIAT CLIN N AM, V12, P643
Stone MH, 2001, J PERS DISORD, V15, P1, DOI 10.1521/pedi.15.1.1.18646
Strubel A., 2007, NEW SCH PSYCHOL B, V5, P41
Tetzlaff J., 2009, BMJ-BRIT MED J, V6, pb2700
Tithecott Richard, 1997, MEN MONSTERS J DAHME
Volavka J, 1999, J NEUROPSYCH CLIN N, V11, P307
Volkmar F. R., 2000, ASPERGER SYNDROME, V27, P25
Wessely S, 2012, LANCET, V379, P1563, DOI 10.1016/S0140-6736(12)60655-2
Whitman TA, 2004, AGGRESS VIOLENT BEH, V9, P693, DOI 10.1016/j.avb.2003.08.003
Whittle B., 2000, PRESCRIPTION MURDER
Wilson D., 1993, J INTELLECTUAL DISAB, V85
Woodbury-Smith MR, 2006, J FORENSIC PSYCHI PS, V17, P108, DOI 10.1080/14789940600589464
NR 151
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-1789
EI 1873-6335
J9 AGGRESS VIOLENT BEH
JI Aggress. Violent Behav.
PD MAY-JUN
PY 2014
VL 19
IS 3
BP 288
EP 301
DI 10.1016/j.avb.2014.04.004
PG 14
WC Criminology & Penology; Psychology, Multidisciplinary
SC Criminology & Penology; Psychology
GA AJ7EN
UT WOS:000337860100011
ER
PT J
AU Baker, CA
Peterson, E
Pulos, S
Kirkland, RA
AF Baker, Crystal A.
Peterson, Eric
Pulos, Steven
Kirkland, Rena A.
TI Eyes and IQ: A meta-analysis of the relationship between intelligence
and "Reading the Mind in the Eyes"
SO INTELLIGENCE
LA English
DT Article
DE Mental state; Mentalizing; RMET; Social cognition; Theory of mind
ID HIGH-FUNCTIONING AUTISM; VOXEL-BASED MORPHOMETRY; SOCIAL COGNITION;
ASPERGER-SYNDROME; FALSE-BELIEF; EMOTIONAL INTELLIGENCE;
ANOREXIA-NERVOSA; MULTIPLE-SCLEROSIS; DOMAIN-SPECIFICITY; LOBE
CONTRIBUTIONS
AB Although the Reading the Mind in the Eyes Test (RMET; Baron-Cohen et al. 1997, 2001) has been used as a measure of mental state understanding in over 250 studies, the extent to which it correlates with intelligence is seldom considered. We conducted a meta-analysis to investigate whether or not a relationship exists between intelligence and performance on the RMET. The analysis of 77 effects sizes with 3583 participants revealed a small positive correlation (r = .24) with no difference between verbal and performance abilities. We conclude that intelligence does play a significant role in performance on the RMET and that verbal and performance abilities contribute to this relationship equally. We discuss these findings in the context of the theory of mind and domain-general resources literature. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Baker, Crystal A.; Peterson, Eric; Pulos, Steven; Kirkland, Rena A.] Univ No Colorado, Sch Psychol Sci, Greeley, CO 80639 USA.
RP Baker, CA (reprint author), Univ No Colorado, Sch Psychol Sci, 501 20th St, Greeley, CO 80639 USA.
EM crystal.baker@unco.edu; eric.peterson@unco.edu; steven.pulos@unco.edu;
rena.kirkland@gmail.com
CR Adams RB, 2010, J COGNITIVE NEUROSCI, V22, P97, DOI 10.1162/jocn.2009.21187
Adler N, 2010, PSYCHIAT RES, V178, P214, DOI 10.1016/j.psychres.2009.11.015
Adolphs R, 2006, BRAIN RES, V1079, P25, DOI 10.1016/j.brainres.2005.12.127
Apperly IA, 2004, J COGNITIVE NEUROSCI, V16, P1773, DOI 10.1162/0898929042947928
Apperly IA, 2007, COGNITION, V103, P300, DOI 10.1016/j.cognition.2006.04.012
Bailey PE, 2008, J GERONTOL B-PSYCHOL, V63, pP219
Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47
BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
Barrett LF, 2007, TRENDS COGN SCI, V11, P327, DOI 10.1016/j.tics.2007.06.003
Beck L, 2012, EMOTION, V12, P503, DOI 10.1037/a0026320
Billington J, 2007, LEARN INDIVID DIFFER, V17, P260, DOI 10.1016/j.lindif.2007.02.004
Bora E, 2007, EUR ARCH PSY CLIN N, V257, P104, DOI 10.1007/s00406-006-0681-3
Bora E, 2006, PSYCHIAT RES, V145, P95, DOI 10.1016/j.psychres.2005.11.003
Borenstein M, 2009, INTRO METAANALYSIS
Botting N, 2008, BRIT J DEV PSYCHOL, V26, P281, DOI 10.1348/026151007X235891
Brand C, 1987, A JENSEN CONSENSUS C, P251
Brent E, 2004, AUTISM, V8, P283, DOI 10.1177/1362361304045217
Camargo M. A., 2007, THESIS U NEW YORK NE
Carroll JM, 2006, J AUTISM DEV DISORD, V36, P949, DOI 10.1007/s10803-006-0127-9
Castelli I, 2010, NEUROPSYCHOLOGIA, V48, P2586, DOI 10.1016/j.neuropsychologia.2010.05.005
Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
CORCORAN R, 1995, SCHIZOPHR RES, V17, P5, DOI 10.1016/0920-9964(95)00024-G
Craig JS, 2004, SCHIZOPHR RES, V69, P29, DOI 10.1016/S0920-9964(03)00154-3
CRAWFORD JR, 1989, BRIT J CLIN PSYCHOL, V28, P267
David N, 2008, J AUTISM DEV DISORD, V38, P593, DOI 10.1007/s10803-007-0425-x
de Achaval D, 2010, NEUROPSYCHOLOGIA, V48, P1209, DOI 10.1016/j.neuropsychologia.2009.12.019
Demurie E, 2011, RES AUTISM SPECT DIS, V5, P126, DOI 10.1016/j.rasd.2010.03.002
Dorris L, 2004, J CHILD PSYCHOL PSYC, V45, P412, DOI 10.1111/j.1469-7610.2004.00232.x
Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
EAGLY AH, 1991, PERS SOC PSYCHOL B, V17, P306, DOI 10.1177/0146167291173011
Ferguson FJ, 2010, PERS INDIV DIFFER, V49, P414, DOI 10.1016/j.paid.2010.04.009
Garrido L, 2009, BRAIN, V132, P3443, DOI 10.1093/brain/awp271
Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
Hallerbäck Maria Unenge, 2009, Cogn Neuropsychiatry, V14, P127, DOI 10.1080/13546800902901518
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Harrison A, 2009, CLIN PSYCHOL PSYCHOT, V16, P348, DOI 10.1002/cpp.628
Hassenstab J, 2007, J NERV MENT DIS, V195, P277, DOI 10.1097/01.nmd.0000253794.74540.2d
Havet-Thomassin V, 2006, BRAIN INJURY, V20, P83, DOI 10.1080/02699050500340655
Hefter RL, 2005, NEUROLOGY, V65, P1620, DOI 10.1212/01.wnl.0000184498.16959.c0
Henry JD, 2009, J INT NEUROPSYCH SOC, V15, P277, DOI 10.1017/S1355617709090195
Henry JD, 2009, PSYCHOL AGING, V24, P252, DOI 10.1037/a0014001
Henry P. J., 2005, HDB UNDERSTANDING ME, P295
Hirao K, 2008, SCHIZOPHR RES, V105, P165, DOI 10.1016/j.schres.2008.07.021
Hunt E., 2005, COGNITION INTELLIGEN, P1
Hunter J. E., 2004, METHODS METAANALYSIS, V2nd
Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
Ingersoll B, 2010, J AUTISM DEV DISORD, V40, P590, DOI 10.1007/s10803-009-0907-0
Jensen A. R., 1998, G FACTOR SCI MENTAL
Kaland N, 2008, J AUTISM DEV DISORD, V38, P1112, DOI 10.1007/s10803-007-0496-8
Kidd DC, 2013, SCIENCE, V342, P377, DOI 10.1126/science.1239918
Kirkland R. A., 2012, ASS PSYCH SCI ANN C
Kirkland R. A., 2013, N AM J PSYCHOL, V15, P121
Kline P., 1991, INTELLIGENCE PSYCHOM
Lau J. Y. H., 2006, THESIS U HONG KONG C
Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
Lawrence K, 2003, NEUROPSYCHOLOGIA, V41, P894, DOI 10.1016/S0028-3932(03)00002-2
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
LEWIS C, 1990, CHILD DEV, V61, P1514, DOI 10.1111/j.1467-8624.1990.tb02879.x
Lipsey M. W., 2001, PRACTICAL METAANALYS
Lysaker PH, 2010, SCHIZOPHR RES, V124, P81, DOI 10.1016/j.schres.2010.06.019
Mar RA, 2006, J RES PERS, V40, P694, DOI 10.1016/j.jrp.2005.08.002
MATTHEWS GB, 2005, BLACKW GREAT MIND, P1
Mayer JD, 2008, ANNU REV PSYCHOL, V59, P507, DOI 10.1146/annurev.psych.59.103006.093646
McGlade N, 2008, BRIT J PSYCHIAT, V193, P77, DOI 10.1192/bjp.bp.107.044198
Meyer J, 2006, J PSYCHOL, V140, P199, DOI 10.3200/JRLP.140.3.199-207
Milligan K, 2007, CHILD DEV, V78, P622, DOI 10.1111/j.1467-8624.2007.01018.x
Montgomery J., 2007, THESIS U SASKATCHEWA
Moran JM, 2013, BEHAV BRAIN RES, V237, P32, DOI 10.1016/j.bbr.2012.09.020
Murphy NA, 2011, INTELLIGENCE, V39, P54, DOI 10.1016/j.intell.2010.10.001
Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
Peterson E., 2012, FRONTIERS PSYCHOL PE, V3, P1
Phillips L. H., 2002, J GERONTOL B-PSYCHOL, V57, P526
Plesa Skewerer D. P., 2006, COGNITIVE NEUROPSYCH, V23, P338
Pons F, 2003, SCAND J PSYCHOL, V44, P347, DOI 10.1111/1467-9450.00354
Premack D., 1978, BEHAVIORAL BRAIN SCI, V4, P515, DOI [10.1017/S0140525X00076512, DOI 10.1017/S0140525X00076512]
Raven J, 2000, COGNITIVE PSYCHOL, V41, P1, DOI 10.1006/cogp.1999.0735
Richell RA, 2003, NEUROPSYCHOLOGIA, V41, P523, DOI 10.1016/S0028-3932(02)00175-6
Riveros R, 2010, SCHIZOPHR RES, V116, P297, DOI 10.1016/j.schres.2009.10.017
Roca M, 2010, COGN BEHAV NEUROL, V23, P152, DOI 10.1097/WNN.0b013e3181e078de
Roca M, 2008, MULT SCLER, V14, P364, DOI 10.1177/1352458507084270
Rosenberg M. S., 2000, METAWIN STAT SOFTWAR
Rosenberg MS, 2005, EVOLUTION, V59, P464, DOI 10.1554/04-602
Russell TA, 2009, PSYCHIAT RES, V168, P181, DOI 10.1016/j.psychres.2008.10.028
Sabbagh MA, 2004, BRAIN COGNITION, V55, P209, DOI 10.1016/j.banc.2003.04.002
Schwartz C, 2010, J AUTISM DEV DISORD, V40, P100, DOI 10.1007/s10803-009-0843-z
Sharp C, 2008, COGNITION EMOTION, V22, P1149, DOI 10.1080/02699930701667586
Shaw P, 2005, J COGNITIVE NEUROSCI, V17, P1410, DOI 10.1162/0898929054985491
Siegal M, 2002, NAT REV NEUROSCI, V3, P463, DOI 10.1038/nrn844
Slessor G, 2007, PSYCHOL AGING, V22, P639, DOI 10.1037/0882-7974.22.3.639
Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
Stone VE, 2006, SOC NEUROSCI-UK, V1, P309, DOI 10.1080/17470910601029221
Strenze T, 2007, INTELLIGENCE, V35, P401, DOI 10.1016/j.intell.2006.09.004
Strong E., 2011, J VISION, V11
Szily E, 2009, PSYCHOPATHOLOGY, V42, P229, DOI 10.1159/000218520
Tso IF, 2010, SCHIZOPHR RES, V122, P156, DOI 10.1016/j.schres.2009.12.007
Turkstra LS, 2008, BRAIN INJURY, V22, P397, DOI 10.1080/02699050802027059
Van Rooy DL, 2004, J VOCAT BEHAV, V65, P71, DOI 10.1016/S0001-8791(03)00076-9
Wang MC, 1998, PSYCHOL METHODS, V3, P46, DOI 10.1037//1082-989X.3.1.46
Wang YG, 2008, PSYCHIAT RES, V161, P153, DOI 10.1016/j.psychres.2007.07.018
Wellman HM, 2001, CHILD DEV, V72, P655, DOI 10.1111/1467-8624.00304
Wigan E., 2007, THESIS U EDINBURGH S
Wilhelm O., 2005, HDB UNDERSTANDING ME, P1
Woodward LJ, 2000, J CHILD PSYCHOL PSYC, V41, P191, DOI 10.1017/S002196309900520X
Wynn JK, 2010, BIOL PSYCHIAT, V67, P940, DOI 10.1016/j.biopsych.2009.11.024
NR 108
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0160-2896
EI 1873-7935
J9 INTELLIGENCE
JI Intelligence
PD MAY-JUN
PY 2014
VL 44
BP 78
EP 92
DI 10.1016/j.intell.2014.03.001
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA AJ6DN
UT WOS:000337780000011
ER
PT J
AU Neiworth, JJ
Whillock, KM
Kim, SH
Greenberg, JR
Jones, KB
Patel, AR
Steefel-Moore, DL
Shaw, AJ
Rupert, DD
Gauer, JL
Kudura, AG
AF Neiworth, Julie J.
Whillock, Katherine M.
Kim, Seo Hyun
Greenberg, Julia R.
Jones, Katherine B.
Patel, Anushka R.
Steefel-Moore, David L.
Shaw, Allyson J.
Rupert, Deborah D.
Gauer, Jacqueline L.
Kudura, Aisha G.
TI Gestalt Principle Use in College Students, Children With Autism,
Toddlers (Homo sapiens), and Cotton Top Tamarins (Saguinus oedipus)
SO JOURNAL OF COMPARATIVE PSYCHOLOGY
LA English
DT Article
DE tamarin; primate; perception; Gestalt; autism
ID MONKEYS CEBUS-APELLA; CHIMPANZEES PAN-TROGLODYTES; HIERARCHICAL
VISUAL-STIMULI; PIGEONS COLUMBA-LIVIA; BRAIN EVOLUTION; CORPUS-CALLOSUM;
MACACA-MULATTA; HUMANS; PERCEPTION; ATTENTION
AB The use of Gestalt principles of proximity, similarity, and closure to recognize objects by configural superiority was examined in college students, low- and high-functioning children with autism, toddlers, and adult cotton top tamarin monkeys. At issue was whether the monkeys showed differences from humans in perceptual processing and whether they showed any similarities with clinical or developmental groups. The method required a pointing response to discriminate an odd item in a 4-item visual display. All subjects were trained to a high accuracy to point to the odd item before being tested with graphic stimuli that differentiated feature changes based on configural superiority. The results were that college students and high-functioning children with autism responded faster and more accurately to trials in which the odd item was easily noticed by the use of Gestalt principles and configural superiority. Toddlers also responded more accurately to the Gestalt trials, but without being faster at making the response. Low-functioning children with autism and tamarins showed no advantage to Gestalt trials but exhibited different processing styles. The implications of these findings to track the evolution of human perception and to develop a primate model for the perceptual deficits of autism are discussed.
C1 [Neiworth, Julie J.] Carleton Coll, Dept Psychol, Northfield, MN 55057 USA.
[Whillock, Katherine M.] Penn State Univ, University Pk, PA 16802 USA.
[Kim, Seo Hyun] Columbia Univ, Dept Psychol & Educ, New York, NY 10027 USA.
[Greenberg, Julia R.] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA.
[Jones, Katherine B.] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
[Patel, Anushka R.] Harvard Univ, Cambridge, MA 02138 USA.
[Steefel-Moore, David L.] MATCH Publ Charter Sch, Plymouth, MN USA.
[Shaw, Allyson J.] Columbia Univ, Teachers Coll, New York, NY 10027 USA.
[Rupert, Deborah D.] Columbia Univ, New York, NY 10027 USA.
[Gauer, Jacqueline L.] Univ Texas Dallas, Dallas, TX 75230 USA.
[Kudura, Aisha G.] New Mexico State Univ, Las Cruces, NM 88003 USA.
RP Neiworth, JJ (reprint author), Carleton Coll, Dept Psychol, One North Coll St, Northfield, MN 55057 USA.
EM jneiwort@carleton.edu
FU NIMH AREA [1-R15MH071232-01A2]
FX This research was funded by NIMH AREA 1-R15MH071232-01A2 to Julie
Neiworth, principal investigator. We acknowledge the support of Julia
Strand and Sarah Meerts of Carleton College, for editing advice on
earlier versions of this article; Kristen A. Miller for help in
collecting data from the toddlers; and Shaun M. Sawtell for help in
collecting data from college students and tamarins.
CR Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x
Boring E. G., 1942, SENSATION PERCEPTION
Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x
Burns JK, 2006, PROG NEURO-PSYCHOPH, V30, P797, DOI 10.1016/j.pnpbp.2006.01.006
Cassia VM, 2002, J EXP PSYCHOL GEN, V131, P398, DOI 10.1037//0096-3445.131.3.398
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
CERELLA J, 1980, PATTERN RECOGN, V12, P1, DOI 10.1016/0031-3203(80)90048-5
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
De Lillo C, 2005, J COMP PSYCHOL, V119, P155, DOI 10.1037/0735-7036.119.2.155
De Lillo C, 2012, BEHAV BRAIN RES, V226, P445, DOI 10.1016/j.bbr.2011.09.040
De Lillo C, 2011, J EXP PSYCHOL ANIM B, V37, P341, DOI 10.1037/a0022989
Dukette D, 2001, DEVELOPMENTAL SCI, V4, P233, DOI 10.1111/1467-7687.00168
EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794
Fagot J, 1999, J COMP PSYCHOL, V113, P3, DOI 10.1037/0735-7036.113.1.3
Fagot J, 1997, J EXP PSYCHOL HUMAN, V23, P429, DOI 10.1037/0096-1523.23.2.429
Frith U., 1989, AUTISM EXPLAINING EN
Fujita K, 2001, PRIMATE ORIGINS OF HUMAN COGNITION AND BEHAVIOR, P29
Fujita K, 2001, PERCEPT PSYCHOPHYS, V63, P115, DOI 10.3758/BF03200507
Fujita K, 2005, J EXP PSYCHOL ANIM B, V31, P387, DOI 10.1037/0097-7403.31.4.387
Goto K, 2012, J EXP PSYCHOL ANIM B, V38, P125, DOI 10.1037/a0026899
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Herbert MR, 2005, NEUROSCIENTIST, V11, P417, DOI 10.1177/0091270005278866
Hopkins WD, 2002, ANIM COGN, V5, P27, DOI 10.1007/s10071-001-0121-8
Kelly DM, 2003, J COMP PSYCHOL, V117, P200, DOI 10.1037/0735-7036.117.2.200
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
KIMCHI R, 1992, PSYCHOL BULL, V112, P24, DOI 10.1037/0033-2909.112.1.24
Leigh SR, 2004, AM J PRIMATOL, V62, P139, DOI 10.1002/ajp.20012
Matsuno T, 2006, BEHAV BRAIN RES, V172, P219, DOI 10.1016/j.bbr.2006.05.004
MCCLELLAND JL, 1978, J EXP PSYCHOL HUMAN, V4, P210, DOI 10.1037//0096-1523.4.2.210
Mottron L, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P131
Neiworth JJ, 2006, J COMP PSYCHOL, V120, P323, DOI 10.1037/0735-7036.120.4.323
Neiworth JJ, 2004, DEVELOPMENTAL SCI, V7, P185, DOI 10.1111/j.1467-7687.2004.00337.x
Neiworth JJ, 2002, J COMP PSYCHOL, V116, P3, DOI 10.1037//0735-7036.116.1.3
Neiworth JJ, 2003, ANIM COGN, V6, P27, DOI 10.1007/s10071-003-0162-2
Neiworth JJ, 2001, J COMP PSYCHOL, V115, P432, DOI 10.1037//0735-7036.115.4.432
Neiworth JJ, 2009, J COMP PSYCHOL, V123, P10, DOI 10.1037/a0012662
Penn HE, 2006, CHILD NEUROPSYCHOL, V12, P57, DOI 10.1080/09297040500253546
POMERANTZ JR, 1983, J EXP PSYCHOL GEN, V112, P516, DOI 10.1037/0096-3445.112.4.516
POMERANTZ JR, 1989, J EXP PSYCHOL HUMAN, V15, P635, DOI 10.1037/0096-1523.15.4.635
POMERANTZ JR, 1977, J EXP PSYCHOL HUMAN, V3, P422, DOI 10.1037//0096-1523.3.3.422
Quinn PC, 2002, PSYCHOL SCI, V13, P320, DOI 10.1111/1467-9280.00459
Rilling JK, 1999, NEUROREPORT, V10, P1453, DOI 10.1097/00001756-199905140-00012
SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
Sherr EH, 2005, NEUROLOGY, V65, P1496, DOI 10.1212/01.wnl.0000183066.09239.b6
Silk TJ, 2006, AM J PSYCHIAT, V163, P1440, DOI 10.1176/appi.ajp.163.8.1440
Spinozzi G, 2003, J COMP PSYCHOL, V117, P15, DOI 10.1037/0735-7036.117.1.15
Spinozzi G, 2006, BEHAV BRAIN RES, V166, P45, DOI 10.1016/j.bbr.2005.06.043
Spinozzi G, 2009, J COMP PSYCHOL, V123, P56, DOI 10.1037/a0012674
TEUNISSE JP, 1994, INT J NEUROSCI, V77, P1
WILLIAMS A, 1978, MEM COGNITION, V6, P85, DOI 10.3758/BF03197432
World Health Organisation (WHO), 2009, INT STAT CLASS DIS R, V10th
NR 52
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0735-7036
EI 1939-2087
J9 J COMP PSYCHOL
JI J. Comp. Psychol.
PD MAY
PY 2014
VL 128
IS 2
SI SI
BP 188
EP 198
DI 10.1037/a0034840
PG 11
WC Behavioral Sciences; Psychology; Psychology, Multidisciplinary; Zoology
SC Behavioral Sciences; Psychology; Zoology
GA AJ7TB
UT WOS:000337899000014
PM 24491175
ER
PT J
AU Braun, JM
Kalkbrenner, AE
Just, AC
Yolton, K
Calafat, AM
Sjodin, A
Hauser, R
Webster, GM
Chen, AM
Lanphear, BP
AF Braun, Joseph M.
Kalkbrenner, Amy E.
Just, Allan C.
Yolton, Kimberly
Calafat, Antonia M.
Sjodin, Andreas
Hauser, Russ
Webster, Glenys M.
Chen, Aimin
Lanphear, Bruce P.
TI Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal
Social, Repetitive, and Stereotypic Behaviors in 4-and 5-Year-Old
Children: The HOME Study
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID ATTENTION DEFICIT/HYPERACTIVITY DISORDER; POLYBROMINATED DIPHENYL
ETHERS; PERSISTENT ORGANIC POLLUTANTS; AUTISM SPECTRUM DISORDERS;
BISPHENOL-A EXPOSURE; POLYFLUOROALKYL CHEMICALS; HIERARCHICAL
REGRESSION; ORGANOCHLORINE EXPOSURE; CHILDHOOD BEHAVIOR; PERINATAL
EXPOSURE
AB Background: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult.
Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors.
Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a two-stage hierarchical analysis to account for repeated measures and confounding by correlated EDCs.
Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (<= 1.5). Each 2-SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE-28) (beta = 2.5; 95% CI: -0.6, 5.6) or trans-nonachlor (beta = 4.1; 95% CI: 0.8-7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB-178 (beta = -3.0; 95% CI: -6.3, 0.2), beta-hexachlorocyclohexane (beta = -3.3; 95% CI: -6.1, -0.5), or PBDE-85 (beta = -3.2; 95% CI: -5.9, -0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (beta = -2.0; 95% CI: -4.4, 0.4).
Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, beta-hexachlorocyclohexane, PCB-178, PBDE-28, PBDE-85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors.
C1 [Braun, Joseph M.] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
[Kalkbrenner, Amy E.] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA.
[Just, Allan C.; Hauser, Russ] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
[Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA.
[Calafat, Antonia M.; Sjodin, Andreas] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA.
[Webster, Glenys M.; Lanphear, Bruce P.] Simon Fraser Univ, Fac Hlth & Sci, Burnaby, BC V5A 1S6, Canada.
[Webster, Glenys M.; Lanphear, Bruce P.] BC Childrens & Womens Hosp, Child & Family Res Inst, Vancouver, BC, Canada.
[Chen, Aimin] Univ Cincinnati, Dept Environm Hlth, Div Epidemiol & Biostat, Cincinnati, OH USA.
RP Braun, JM (reprint author), Brown Univ, Dept Epidemiol, Box G S121-2, Providence, RI 02912 USA.
EM joseph_braun_1@brown.edu
RI Sjodin, Andreas/F-2464-2010; Braun, Joseph/H-8649-2014
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11
Beck A. T., 1996, BECK DEPRESSION INVE, V2nd
Bellinger DC, 2004, ENVIRON RES, V95, P394, DOI 10.1016/j.evnres.2003.07.013
Bolte S, 2008, AUTISM RES, V1, P354, DOI 10.1002/aur.49
Braun JM, 2009, ENVIRON HEALTH PERSP, V117, P1945, DOI 10.1289/ehp.0900979
Braun JM, 2012, DEV MED CHILD NEUROL, V54, P1068, DOI 10.1111/j.1469-8749.2012.04372.x
Braun JM, 2012, ENVIRON HEALTH PERSP, V120, P739, DOI 10.1289/ehp.1104139
Braun JM, 2011, PEDIATRICS, V128, P873, DOI 10.1542/peds.2011-1335
Caldwell B. M., 2003, HOME INVENTORY ADM M
CASSIDY RA, 1994, TOXICOL APPL PHARM, V126, P326, DOI 10.1006/taap.1994.1123
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
CDC (Centers for Disease Control and Prevention), 2009, 4 CDCP
Cheslack-Postava K, 2013, NEUROTOXICOL TERATOL, V38, P1, DOI 10.1016/j.ntt.2013.04.001
Cole SR, 2008, AM J EPIDEMIOL, V168, P656, DOI 10.1093/aje/kwn164
Constantino JN, 2005, SOCIAL RESPONSIVENES
de Cock M, 2012, ACTA PAEDIATR, V101, P811, DOI 10.1111/j.1651-2227.2012.02693.x
De Roos AJ, 2001, AM J IND MED, V39, P477, DOI 10.1002/ajim.1041
Dingemans MML, 2011, ENVIRON HEALTH PERSP, V119, P900, DOI 10.1289/ehp.1003035
Engel SM, 2010, ENVIRON HEALTH PERSP, V118, P565, DOI 10.1289/ehp.0901470
Eskenazi B, 2013, ENVIRON HEALTH PERSP, V121, P257, DOI 10.1289/ehp.1205597
Eubig PA, 2010, ENVIRON HEALTH PERSP, V118, P1654, DOI 10.1289/ehp.0901852
Gelman A, 2008, STAT MED, V27, P2865, DOI 10.1002/sim.3107
Geyer H, 2004, ORGANOHALOGEN COMPOU, V66, P3867
Gioiosa L, 2013, HORM BEHAV, V63, P598, DOI 10.1016/j.yhbeh.2013.02.016
GREENLAND S, 1994, ARCH ENVIRON HEALTH, V49, P9
GREENLAND S, 1994, ENVIRON HEALTH PERSP, V102, P33
Hamers T, 2006, TOXICOL SCI, V92, P157, DOI 10.1093/toxsci/kfj187
Hammock EAD, 2006, PHILOS T R SOC B, V361, P2187, DOI 10.1098/rstb.2006.1939
Henrichs J, 2013, CLIN ENDOCRINOL, V79, P152, DOI 10.1111/cen.12227
Herbstman JB, 2010, ENVIRON HEALTH PERSP, V118, P712, DOI 10.1289/ehp.0901340
Hertz-Picciotto I, 2011, ENVIRON HEALTH-GLOB, V10, DOI 10.1186/1476-069X-10-1
Hoffman K, 2010, ENVIRON HEALTH PERSP, V118, P1762, DOI 10.1289/ehp.1001898
Hornung RW, 1990, APPL OCCUP ENV HYG, V5, P46, DOI DOI 10.1080/1047322X.1990.10389587
Howdeshell KL, 2008, TOXICOL SCI, V105, P153, DOI 10.1093/toxsci/kfn077
Jones R, 2012, ORGANOALOGEN COMPD, V74, P97
Jones RM, 2013, BEHAV BRAIN RES, V251, P113, DOI 10.1016/j.bbr.2012.10.037
Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76
Kapadia R, 2008, FRONT BIOSCI-LANDMRK, V13, P1813, DOI 10.2741/2802
Kuklenyik Z, 2005, ANAL CHEM, V77, P6085, DOI 10.1021/ac050671l
Landrigan PJ, 2012, ENVIRON HEALTH PERSP, V120, pA258, DOI 10.1289/ehp.1104285
Meeker JD, 2009, ENVIRON HEALTH-GLOB, V8, DOI 10.1186/1476-069X-8-32
Miodovnik A, 2011, NEUROTOXICOLOGY, V32, P261, DOI 10.1016/j.neuro.2010.12.009
Mitchell MM, 2012, ENVIRON MOL MUTAGEN, V53, P589, DOI 10.1002/em.21722
Olsen GW, 2007, ENVIRON HEALTH PERSP, V115, P1298, DOI 10.1289/ehp.10009
Patterson DG, 2009, ENVIRON SCI TECHNOL, V43, P1211, DOI 10.1021/es801966w
Power MC, 2013, NEUROEPIDEMIOLOGY, V40, P125, DOI 10.1159/000342310
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
Ronald A, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2010.00223
Safe SH, 1998, ENVIRON HEALTH PERSP, V106, P1051, DOI 10.2307/3434151
Sagiv SK, 2010, AM J EPIDEMIOL, V171, P593, DOI 10.1093/aje/kwp427
Schisterman EF, 2009, EPIDEMIOLOGY, V20, P488, DOI 10.1097/EDE.0b013e3181a819a1
Silva MJ, 2007, J CHROMATOGR B, V860, P106, DOI 10.1016/j.jchromb.2007.10.023
Sjodin A, 2008, ENVIRON SCI TECHNOL, V42, P1377, DOI 10.1021/es702451p
Stein CR, 2013, EPIDEMIOLOGY, V24, P590, DOI 10.1097/EDE.0b013e3182944432
Van den Berg M, 2006, TOXICOL SCI, V93, P223, DOI 10.1093/toxsci/kfl055
Wechsler D, 1999, WECHSLER ABBREVIATED
Witte JS, 1998, EPIDEMIOLOGY, V9, P563, DOI 10.1097/00001648-199809000-00016
Wolff MS, 2000, CANCER EPIDEM BIOMAR, V9, P271
Wolstenholme JT, 2012, ENDOCRINOLOGY, V153, P3828, DOI 10.1210/en.2012-1195
Woodruff TJ, 2011, ENVIRON HEALTH PERSP, V119, P878, DOI 10.1289/ehp.1002727
Ye XY, 2008, ANAL CHIM ACTA, V622, P150, DOI 10.1016/j.aca.2008.05.068
NR 63
TC 10
Z9 10
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2014
VL 122
IS 5
BP 513
EP 520
DI 10.1289/ehp.1307261
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AJ3ZC
UT WOS:000337606300022
PM 24622245
ER
PT J
AU Atkin, K
Tozer, R
AF Atkin, Karl
Tozer, Rosemary
TI Personalisation, family relationships and autism: Conceptualising the
role of adult siblings
SO JOURNAL OF SOCIAL WORK
LA English
DT Article
DE Social work; autism; carers; European; family support; learning
disability; social support
ID EXPERIENCE
AB .Summary: Current policy discourses demonstrate a weak connection to broader theoretical debates about family obligation and in particular how family responsibilities become negotiated over time and across the life course. How policy imagines family care can, therefore, be different to the actual experiences of families. This qualitative paper, using semi-structured interviews, explores the experience of a particularly neglected group, adult siblings, who have a brother or sister with autism (plus learning disability). We spoke to 21 adult siblings, met with 12 of their siblings with autism and talked to 12 health and social care professionals.
Findings: Our analysis suggests that connectedness and commitment, which remained subject to continuous redefinition by all family members, informed sibling relationships Practitioners, however, struggle to engage with this complexity, thereby undermining the extent siblings' relationships can be realised.
Application: The paper concludes that policy initiatives are at risk of becoming an uneasy compromise, in which the need to offer choice occurs alongside the 'problem' of managing family care. Sibling relationships are more than simply 'being of' or 'belonging to' a family. They are dynamic, subject to contingency and negotiation. Interventions should be formulated to work with these assumptions, without presupposing a definite experience fixed in time and space. This would not only maximise the disabled siblings' quality of life, but also ensure a more productive and fulfilling context for family relationships.
C1 [Atkin, Karl; Tozer, Rosemary] Univ York, York YO10 5DD, N Yorkshire, England.
RP Atkin, K (reprint author), Univ York, Dept Hlth Sci, Seebohm Rowntree Bldg Area 4, York YO10 5DD, N Yorkshire, England.
EM karl.atkin@york.ac.uk
CR Arthur A., 2003, BRIT J LEARN DISABIL, V31, P25, DOI DOI 10.1046/J.1468-3156.2003.00193.X
Atkin K, 2010, SOC SCI MED, V71, P386, DOI 10.1016/j.socscimed.2010.04.011
Bauman Z., 1996, INTIMATIONS POSTMODE
Beck U., 1992, RISK SOC NEW MODERNI
Bowey L, 2007, BRIT J SOC WORK, V37, P39, DOI 10.1093/bjsw/bcl052
Boxall K., 2009, POLICY POLIT, V37, P449
Bury M, 2005, RAPID REV CURRENT ST
Carers UK, 2009, FACTS CARERS
Cheal D., 2002, SOCIOLOGY FAMILY LIF
Cicirelli V. G., 1995, SIBLING RELATIONSHIP
CONNIDIS IA, 1992, J MARRIAGE FAM, V54, P972, DOI 10.2307/353176
Costigliola Vincenzo, 2010, EPMA J, V1, P525, DOI 10.1007/s13167-010-0059-5
Davys Deborah, 2010, J Intellect Disabil, V14, P167, DOI 10.1177/1744629510385625
Denzin NK, 1998, LANDSCAPE QUALITATIV
Department of Health, 2008, CAR HEART 21 CENT FA
Department of Health, 2010, CAR PERS IMPR OUTC
Dorr H., 2010, GOOD PRACTICE INVOLV
Fielding N., 1993, RES SOCIAL LIFE, P140
Finch J, 2007, SOCIOLOGY, V41, P65, DOI 10.1177/0038038507072284
Gass K, 2007, J CHILD PSYCHOL PSYC, V48, P167, DOI 10.1111/j.1469-7610.2006.01699.x
Giddens A., 1991, MODERNITY SELF IDENT
Glendinning G., 2010, QUALITY AGEING OLDER, V11, P40
Meyer D., 2008, SUPPORT LEARNING, V23, P113, DOI 10.1111/j.1467-9604.2008.00381.x
Mitchell W., 2009, SOCIAL WORK ED, V28, P309
Morgan D., 1996, FAMILY CONNECTIONS
Northouse LL, 2010, CA-CANCER J CLIN, V60, P317, DOI 10.3322/caac.20081
Orsmond GI, 2007, MENT RETARD DEV D R, V13, P313, DOI 10.1002/mrdd.20171
Pickard S, 2010, SOCIOLOGY, V44, P471, DOI 10.1177/0038038510362482
Riessman C. K., 2008, NARRATIVE METHODS HU
Robinson Sally, 2011, J Intellect Disabil, V15, P63, DOI 10.1177/1744629511403649
Rose N., 1999, POWERS OF FREEDOM
Ross P, 2006, J INTELLECT DEV DIS, V31, P77, DOI 10.1080/13668250600710864
Silverman D., 2004, DOING QUALITATIVE RE, V2nd
Sointu E, 2005, SOCIOL REV, V53, P255, DOI 10.1111/j.1467-954X.2005.00513.x
Taylor C., 2004, MODERN SOCIAL IMAGIN
Twigg J., 1994, CARERS PERCEIVED POL
Whiteman S. D., 2011, J FAMILY THEORY REV, V3, P124
Williams F., 2004, RETHINKING FAMILIES
Williams SJ, 2000, SOCIOL HEALTH ILL, V22, P40, DOI 10.1111/1467-9566.00191
Mansell Ian, 2010, J Intellect Disabil, V14, P21, DOI 10.1177/1744629510373045
Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
NR 41
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1468-0173
EI 1741-296X
J9 J SOC WORK
JI J. Soc. Work
PD MAY
PY 2014
VL 14
IS 3
BP 225
EP 242
DI 10.1177/1468017313476453
PG 18
WC Social Work
SC Social Work
GA AJ4EH
UT WOS:000337624000001
ER
PT J
AU Zeidan-Chulia, F
de Oliveira, BHN
Salmina, AB
Casanova, MF
Gelain, DP
Noda, M
Verkhratsky, A
Moreira, JCF
AF Zeidan-Chulia, F.
de Oliveira, B-H N.
Salmina, A. B.
Casanova, M. F.
Gelain, D. P.
Noda, M.
Verkhratsky, A.
Moreira, J. C. F.
TI Altered expression of Alzheimer's disease-related genes in the
cerebellum of autistic patients: a model for disrupted brain connectome
and therapy
SO CELL DEATH & DISEASE
LA English
DT Article
DE proliferation; mitochondria; APP; magnesium; rapamycin
ID AMYLOID-PRECURSOR-PROTEIN; REGULATED PROTEOLYSIS; SPECTRUM DISORDERS;
COGNITIVE DEFICITS; RNA INTERFERENCE; GAMMA-SECRETASE; NMDA RECEPTORS;
CELL-SURVIVAL; MOUSE MODEL; SAPP-ALPHA
AB Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be elevated in severe autism, leading to the 'anabolic hypothesis' of its etiology. Here we performed a focused microarray analysis of genes belonging to NOTCH and WNT signaling cascades, as well as genes related to AD and apoptosis pathways in cerebellar samples from autistic individuals, to provide further evidence for pathological relevance of these cascades for autism. By using the limma package from R and false discovery rate, we demonstrated that 31% (116 out of 374) of the genes belonging to these pathways displayed significant changes in expression (corrected P-values <0.05), with mitochondria- related genes being the most downregulated. We also found upregulation of GRIN1, the channel-forming subunit of NMDA glutamate receptors, and MAP3K1, known activator of the JNK and ERK pathways with anti-apoptotic effect. Expression of PSEN2 (presinilin 2) and APBB1 (or F65) were significantly lower when compared with control samples. Based on these results, we propose a model of NMDA glutamate receptor-mediated ERK activation of alpha-secretase activity and mitochondrial adaptation to apoptosis that may explain the early brain overgrowth and disruption of synaptic plasticity and connectome in autism. Finally, systems pharmacology analyses of the model that integrates all these genes together (NOWADA) highlighted magnesium (Mg2+) and rapamycin as most efficient drugs to target this network model in silico. Their potential therapeutic application, in the context of autism, is therefore discussed.
C1 [Zeidan-Chulia, F.; de Oliveira, B-H N.; Gelain, D. P.; Moreira, J. C. F.] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Ctr Estudos Estresse Oxidat, BR-90035003 Porto Alegre, RS, Brazil.
[Salmina, A. B.] Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk, Russia.
[Casanova, M. F.] Univ Louisville, Dept Psychiat & Behav Sci, Louisville, KY 40292 USA.
[Noda, M.] Kyushu Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol, Fukuoka 812, Japan.
[Verkhratsky, A.] Univ Manchester, Fac Life Sci, Manchester, Lancs, England.
[Verkhratsky, A.] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.
[Verkhratsky, A.] Univ Basque Country UPV EHU, Dept Neurosci, Leioa, Spain.
RP Zeidan-Chulia, F (reprint author), Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Ctr Estudos Estresse Oxidat, Rua Ramiro Barcelos 2600 ANEXO, BR-90035003 Porto Alegre, RS, Brazil.
EM fzchulia.biomed@gmail.com
RI Verkhratsky, Alexei/J-4527-2013; Zeidan Chulia, Fares/E-5605-2015
OI Verkhratsky, Alexei/0000-0003-2592-9898;
FU FAPERGS [PqG 1008860, PqG 1008857, ARD11/1893-7, PRONEX 1000274]; CAPES
[PROCAD 066/2007]; CNPq [558289/2008-8, 302330/2009-7]; PROPESQ-UFRGS
FX First of all, our sincere apologies to the authors whose work have not
been cited in the present study because of space considerations. We
thank Brazilian research funding agencies FAPERGS (PqG 1008860, PqG
1008857, ARD11/1893-7, and PRONEX 1000274), CAPES (PROCAD 066/2007),
CNPq (558289/2008-8 and 302330/2009-7), as well as PROPESQ-UFRGS for
supporting this work.
CR Aida T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036853
Andrasi E, 2005, J ALZHEIMERS DIS, V7, P273
Ashwood P, 2004, AUTOIMMUN REV, V3, P557, DOI 10.1016/j.autrev.2004.07.036
Bailey AR, 2013, GLIA, V61, P1556, DOI 10.1002/glia.22544
Boo JH, 2008, BIOCHEM BIOPH RES CO, V372, P913, DOI 10.1016/j.bbrc.2008.05.153
Braak H, 1998, PROG BRAIN RES, V117, P267
Cai Z, 2012, J NEUROSCI RES, V90, P1105, DOI 10.1002/jnr.23011
Caille I, 2004, DEVELOPMENT, V131, P2173, DOI 10.1242/dev.01103
Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x
Castro MAA, 2009, BIOINFORMATICS, V25, P1468, DOI 10.1093/bioinformatics/btp246
Cheng GJ, 2002, EXP NEUROL, V175, P407, DOI 10.1006/exnr.2002.7920
Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
Courchesne E, 2005, DEV PSYCHOPATHOL, V17, P577, DOI 10.1017/S0954579405050285
Demars MP, 2011, STEM CELL RES THER, V2, DOI 10.1186/scrt77
Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788
Frye Richard E, 2013, Front Public Health, V1, P31, DOI 10.3389/fpubh.2013.00031
Gakhar-Koppole N, 2008, EUR J NEUROSCI, V28, P871, DOI 10.1111/j.1460-9568.2008.06398.x
Gentleman RC, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-10-r80
Ginsberg MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044736
Guevara-Campos J, 2013, METAB BRAIN DIS, V28, P605, DOI 10.1007/s11011-013-9419-x
He P, 2009, J NEUROSCI, V29, P6545, DOI 10.1523/JNEUROSCI.0421-09.2009
Hooper SD, 2005, BIOINFORMATICS, V21, P4432, DOI 10.1093/bioinformatics/bti696
KERBESHIAN J, 1987, J CLIN PSYCHOPHARM, V7, P401
Kojro E, 2009, J ALZHEIMERS DIS, V16, P865, DOI 10.3233/JAD-2009-0998
Lahiri DK, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00094
Laurence JA, 2005, CEREBELLUM, V4, P206, DOI 10.1080/14734220500208846
Lee SF, 2011, J BIOL CHEM, V286, P27447, DOI 10.1074/jbc.M111.243154
LELORD G, 1981, J AUTISM DEV DISORD, V11, P219, DOI 10.1007/BF01531686
Li W, 2013, J NEUROSCI, V33, P8423, DOI 10.1523/JNEUROSCI.4610-12.2013
Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
Lu SY, 2013, PROTEINS, V81, P740, DOI 10.1002/prot.24221
Mattson MP, 1997, PHYSIOL REV, V77, P1081
Mills JL, 2007, CLIN ENDOCRINOL, V67, P230, DOI 10.1111/j.1365-2265.2007.02868.x
Miyazaki K, 2004, BRAIN DEV-JPN, V26, P292, DOI 10.1016/S0387-7604(03)00168-2
Nunes MA, 2013, CURR ALZHEIMER RES, V10, P104
Ohsawa I, 1999, EUR J NEUROSCI, V11, P1907, DOI 10.1046/j.1460-9568.1999.00601.x
RAFF MC, 1993, SCIENCE, V262, P695, DOI 10.1126/science.8235590
Ray B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020405
Reeber Stacey L, 2013, Front Syst Neurosci, V7, P83, DOI 10.3389/fnsys.2013.00083
Ricci S, 2013, NEUROTOX RES, V24, P491, DOI 10.1007/s12640-013-9393-4
Rodriguez JJ, 2011, J ANAT, V219, P78, DOI 10.1111/j.1469-7580.2011.01343.x
Rogers Tiffany D, 2013, Front Syst Neurosci, V7, P15, DOI 10.3389/fnsys.2013.00015
Rosado JO, 2011, CURR CANCER DRUG TAR, V11, P849
Sabo SL, 1999, J BIOL CHEM, V274, P7952, DOI 10.1074/jbc.274.12.7952
Selkoe DJ, 2001, PHYSIOL REV, V81, P741
Smoot ME, 2011, BIOINFORMATICS, V27, P431, DOI 10.1093/bioinformatics/btq675
Sokol DK, 2006, J CHILD NEUROL, V21, P444, DOI 10.2310/7010.2006.00130
Spilman P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009979
Stadler F, 2005, J NEUROCHEM, V94, P324, DOI 10.1111/j.1471-4159.2005.03190.x
Strambi M, 2006, BIOL TRACE ELEM RES, V109, P97, DOI 10.1385/BTER:109:2:097
Suh J, 2011, J NEUROCHEM, V119, P377, DOI 10.1111/j.1471-4159.2011.07419.x
Tang GM, 2013, NEUROBIOL DIS, V54, P349, DOI 10.1016/j.nbd.2013.01.006
Tavassoli E, 2013, INT J DEV NEUROSCI, V31, P790, DOI 10.1016/j.ijdevneu.2013.09.010
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Verges DK, 2011, J NEUROSCI, V31, P11328, DOI 10.1523/JNEUROSCI.0607-11.2011
Wain HM, 2004, NUCLEIC ACIDS RES, V32, pD255, DOI 10.1093/nar/gkh072
Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
Wei HG, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-52
Woo HN, 2009, BIOCHEM BIOPH RES CO, V390, P1093, DOI 10.1016/j.bbrc.2009.10.093
Xie ZC, 2007, J BIOL CHEM, V282, P4318, DOI 10.1074/jbc.M609293200
Young-Pearse TL, 2007, J NEUROSCI, V27, P14459, DOI 10.1523/JNEUROSCI.4701-07.2007
Yu WF, 2010, AM J PATHOL, V176, P2209, DOI 10.2353/ajpath.2010.090496
Yujiri T, 1998, SCIENCE, V282, P1911, DOI 10.1126/science.282.5395.1911
Zampese Enrico, 2011, Commun Integr Biol, V4, P357, DOI 10.4161/cib.4.3.15160
Zampese E, 2011, P NATL ACAD SCI USA, V108, P2777, DOI 10.1073/pnas.1100735108
Zeidan-Chulia F, 2011, ACTA ODONTOL SCAND, V69, P193, DOI 10.3109/00016357.2010.549505
Zeidan-Chulia F, 2014, NEUROSCI BIOBEHAV R, V38, P160, DOI 10.1016/j.neubiorev.2013.11.008
Zeidan-Chulia F, 2013, NEUROMOL MED, V15, P364, DOI 10.1007/s12017-013-8224-3
Zhang BL, 2000, J BIOL CHEM, V275, P25299, DOI 10.1074/jbc.M001027200
Zhang H, 2012, J NEUROCHEM, V120, P9, DOI 10.1111/j.1471-4159.2011.07519.x
NR 70
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD MAY
PY 2014
VL 5
SI SI
AR e1250
DI 10.1038/cddis.2014.227
PG 13
WC Cell Biology
SC Cell Biology
GA AI9DN
UT WOS:000337229300050
PM 24853428
ER
PT J
AU Bink, M
van Nieuwenhuizen, C
Popma, A
Bongers, IL
van Boxtel, GJM
AF Bink, Marleen
van Nieuwenhuizen, Chijs
Popma, Arne
Bongers, Ilja L.
van Boxtel, Geert J. M.
TI Neurocognitive Effects of Neurofeedback in Adolescents With ADHD: A
Randomized Controlled Trial
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID DEFICIT-HYPERACTIVITY-DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; PERVASIVE
DEVELOPMENTAL DISORDERS; AUTISM SPECTRUM DISORDERS; CONTROLLED
CLINICAL-TRIAL; DSM-IV; CHILDREN; EEG; PREVALENCE
AB Objective: Neurofeedback aims to reduce symptoms of attention-deficit/hyperactivity disorder (ADHD), mainly attention problems. However, the additional influence of neurofeedback over treatment as usual (TAU) on neurocognitive functioning for adolescents with ADHD remains unclear.
Method: By using a multicenter parallel randomized controlled trial (RCT) design, male adolescents with a DSM-IV-TR diagnosis of ADHD (mean age = 16.1 years; range, 12-24) were randomized to receive either a combination of TAU and neurofeedback (n = 45) or TAU (n = 26). Randomization was computer generated and stratified by age group (ages 12 through 15, 16 through 20, and 21 through 24 years). The neurofeedback intervention consisted of approximately 37 sessions over a period of 25 weeks of theta/sensorimotor rhythm training on the vertex (Cz). Primary neurocognitive outcomes included performance parameters derived from the D2 Test of Attention, the Digit Span backward, the Stroop Color-Word Test and the Tower of London, all assessed preintervention and postintervention. Data were collected between December 2009 and July 2012.
Results: At postintervention, outcomes of attention and/or motor speed were improved, with faster processing times for both intervention conditions and with medium to large effect sizes (range,.p 2 =.08-. 54; P values <.023). In both groups, no improvements for higher executive functions were observed. Results might partly resemble practice effects.
Conclusions: Although neurocognitive outcomes improved in all adolescents receiving treatment for ADHD, no additional value for neurofeedback over TAU was observed. Hence, this study does not provide evidence for using theta/sensorimotor rhythm neurofeedback to enhance neurocognitive performance as additional intervention to TAU for adolescents with ADHD symptoms. (C) Copyright 2014 Physicians Postgraduate Press, Inc.
C1 [Bink, Marleen; van Nieuwenhuizen, Chijs] Tilburg Univ, Sci Ctr Care & Welf Tranzo, NL-5000 LE Tilburg, Netherlands.
[van Boxtel, Geert J. M.] Tilburg Univ, Dept Psychol, NL-5000 LE Tilburg, Netherlands.
[van Nieuwenhuizen, Chijs; Bongers, Ilja L.] GGzE Ctr Child & Adolescent Psychiat, Eindhoven, Netherlands.
[Popma, Arne] VUmc De Bascule, Acad Dept Child & Adolescent Psychiat, Duivendrecht, Netherlands.
RP Bink, M (reprint author), Tilburg Univ, Sci Ctr Care & Welf Tranzo, POB 90153 T618, NL-5000 LE Tilburg, Netherlands.
EM m.bink@ggze.nl
FU Netherlands Organization for Health Research and Development (ZonMw)
[157 002 004]
FX This trial is funded by The Netherlands Organization for Health Research
and Development (ZonMw): 157 002 004.
CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19
[Anonymous], 2005, EEGER NEUR SOFTW 4 2
Arnold LE, 2013, J ATTEN DISORD, V17, P410, DOI 10.1177/1087054712446173
Bakhshayesh AR, 2011, EUR CHILD ADOLES PSY, V20, P481, DOI 10.1007/s00787-011-0208-y
Brickenkamp R, 2007, D2 TEST ATTENTION
Calamia M, 2012, CLIN NEUROPSYCHOL, V26, P543, DOI 10.1080/13854046.2012.680913
Coghill DR, BIOL PSYCHIAT
Corporation IBM, 2012, IBM SPSS STAT WIND V
Cortese S, 2012, EXPERT REV NEUROTHER, V12, P461, DOI [10.1586/ern.12.23, 10.1586/ERN.12.23]
Culbertson W. C., 2005, TOWER LONDON DREXEL
Dallal GE, RANDOMIZATION PLAN G
Duric NS, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-107
Faraone SV, 2010, EUR CHILD ADOLES PSY, V19, P353, DOI 10.1007/s00787-009-0054-3
Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
Gevensleben H, 2009, J CHILD PSYCHOL PSYC, V50, P780, DOI 10.1111/j.1469-7610.2008.02033.x
Gevensleben H, 2009, INT J PSYCHOPHYSIOL, V74, P149, DOI 10.1016/j.ijpsycho.2009.08.005
Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7
Greenhill LL, 2001, J AM ACAD CHILD PSY, V40, P180, DOI 10.1097/00004583-200102000-00012
Gur RC, 2012, NEUROPSYCHOLOGY, V26, P251, DOI 10.1037/a0026712
Hammes JGW, 1978, STROOP COLOR WORD TE
Holtmann M, 2011, DEV MED CHILD NEUROL, V53, P986, DOI 10.1111/j.1469-8749.2011.04043.x
Holtmann M, 2007, PSYCHOPATHOLOGY, V40, P172, DOI 10.1159/000100007
Hutton P, 2012, ACTA PSYCHIAT SCAND, V126, P1, DOI 10.1111/j.1600-0447.2012.01858.x
Kooij JJS, 2005, PSYCHOL MED, V35, P817, DOI 10.1017/S003329170400337X
Kooij JJS, 2002, ADHD ADULTS INTRO DI
Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
Lezak MD, 2004, ORIENTATION ATTENTIO, P349
Lezak MD, 2004, NEUROPSYCHOL ASSESSM, P349
Lofthouse N, 2012, J ATTEN DISORD, V16, P351, DOI 10.1177/1087054711427530
Logemann HNA, 2010, NEUROSCI LETT, V479, P49, DOI 10.1016/j.neulet.2010.05.026
Loo SK, 2012, NEUROTHERAPEUTICS, V9, P569, DOI 10.1007/s13311-012-0131-z
Lubar J. F., 2003, BIOFEEDBACK PRACTITI, P409
Meisel V, 2013, BIOL PSYCHOL, V94, P12, DOI 10.1016/j.biopsycho.2013.04.015
Moriyama TS, 2012, NEUROTHERAPEUTICS, V9, P588, DOI 10.1007/s13311-012-0136-7
Palsson O, 2001, ANN M ASS APPL PSYCH
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
Rapport LJ, 1997, CLIN NEUROPSYCHOL, V11, P375, DOI 10.1080/13854049708400466
Rapport LJ, 1997, J CLIN EXP NEUROPSYC, V19, P655, DOI 10.1080/01688639708403751
Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
Schulz KF, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-18
Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
Sheehan DV, 1997, EUR PSYCHIAT, V12, P232, DOI 10.1016/S0924-9338(97)83297-X
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Snyder SM, 2006, J CLIN NEUROPHYSIOL, V23, P440
Sonuga-Barke EJS, 2013, AM J PSYCHIAT, V170, P275, DOI 10.1176/appi.ajp.2012.12070991
Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/h0054651
Swanson J, 2011, NEUROPSYCHOPHARMACOL, V36, P207, DOI 10.1038/npp.2010.160
van Lieshout M, 2013, CLIN PSYCHOL REV, V33, P539, DOI 10.1016/j.cpr.2013.02.003
Vink M, 2007, DUTCH BASIC PROGRAM
Vollebregt MA, J CHILD PSYCHOL PSYC
van Dongen-Boomsma M, 2013, J CLIN PSYCHIAT, V74, P821, DOI 10.4088/JCP.12m08321
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Willcutt E, 2012, NEUROTHERAPEUTICS, V9, P490, DOI 10.1007/s13311-012-0135-8
NR 54
TC 2
Z9 2
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2014
VL 75
IS 5
BP 535
EP U279
DI 10.4088/JCP.13m08590
PG 14
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AI9LZ
UT WOS:000337255400019
PM 24922488
ER
PT J
AU Sisskin, V
Wasilus, S
AF Sisskin, Vivian
Wasilus, Samantha
TI Lost in the Literature, but Not the Caseload: Working with Atypical
Disfluency from Theory to Practice
SO SEMINARS IN SPEECH AND LANGUAGE
LA English
DT Article
DE Stuttering; atypical disfluency; word-final repetition; autism
ID WORD-FINAL DISFLUENCIES; FUNCTIONING AUTISM; BRAIN-DAMAGE; REPETITIONS;
CHILDREN
AB Atypical disfluency is a frustrating but little addressed clinical problem. The purpose of this article and case study was to summarize what is known about atypical fluency profiles and to describe the presenting behaviors and successful treatment of an unusual fluency profile (numerous word-final syllable repetitions) in a school-aged child. To this end, we describe the speech fluency and associated communication characteristics of a young boy diagnosed with Asperger disorder who was between 7; 2 and 8; 0 when seen for evaluation and treatment. We describe a therapy protocol that was successful in nearly eliminating these atypical disfluencies. The protocol emphasized self-monitoring and was integrated with other goals to improve the child's communication, which had features consistent with mild autism spectrum disorder (ASD). Following an 8-week treatment, the child significantly reduced his percent stuttered syllables of atypical disfluencies (word-final repetition and phrase-final repetition), resulting in significant qualitative improvements to his speech. This case study demonstrates that traditional stuttering modification treatment can be successful in reducing atypical and typical disfluencies in a child with concomitant social language impairment consistent with ASD. The therapy approach reported here may be useful in treatment of other cases having symptoms similar to the child we treated.
C1 [Sisskin, Vivian; Wasilus, Samantha] Univ Maryland, Dept Hearing & Speech Sci, College Pk, MD 20742 USA.
RP Wasilus, S (reprint author), Univ Maryland, Dept Hearing & Speech Sci, 0100 LeFrak Hall, College Pk, MD 20742 USA.
EM samantha.wasilus@gmail.com
CR Ambrose NG, 1999, J SPEECH LANG HEAR R, V42, P895
American Speech-Language-Hearing Association, ASHA SLP HLTH CAR SU
ARDILA A, 1986, BRAIN LANG, V27, P239, DOI 10.1016/0093-934X(86)90018-0
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BIJLEVELD H, 1994, FOLIA PHONIATR LOGO, V46, P250
Bloodstein O., 2008, HDB STUTTERING
Bowers L., 2008, SOCIAL LANGUAGE DEV
CAMARATA SM, 1989, J SPEECH HEAR DISORD, V54, P159
Chermak G, 1986, J PHONETICS, V13, P477
Guitar B., 2005, STUTTERING INTEGRATE
Hietala A, 2005, ANN ASHA CONV NOV 18
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Humphrey B, 2001, WORD FINAL DYSFLUENC
Humphrey BD, 1997, FLA ASSOC SPEECH LAN, V17, P41
Laurent AC, 2004, TOP LANG DISORD, V24, P286
LEBRUN Y, 1985, J FLUENCY DISORD, V10, P137, DOI 10.1016/0094-730X(85)90021-X
LEBRUN Y, 1990, J FLUENCY DISORD, V15, P107, DOI 10.1016/0094-730X(90)90037-S
Manning W. H., 2010, CLIN DECISION MAKING
McAllister J, 2005, J FLUENCY DISORD, V30, P255, DOI 10.1016/j.fluids.2005.05.005
MOWRER DE, 1987, J SPEECH HEAR DISORD, V52, P174
Osborne C, 2004, PERSPECT FLUEN FLUE, V14, P3, DOI 10.1044/ffd14.1.3
Plexico L, 2010, SIG 4 PERSPECTIVES F, V20, P42
Ratner NB, 2005, J FLUENCY DISORD, V30, P163, DOI 10.1016/j.jfludis.2005.04.002
Riley G., 2008, STUTTERING SEVERITY, V4th, pSSI
Rosenfield DB, 1991, SPEECH MOTOR CONTROL
RUDMIN F, 1984, J FLUENCY DISORD, V9, P85, DOI 10.1016/0094-730X(84)90009-3
Scaler Scott K, 2006, P 5 WORLD C FLUENC D
Scott KS, 2014, INT J LANG COMM DIS, V49, P75, DOI 10.1111/1460-6984.12048
Semel E., 2003, CLIN EVALUATION LANG, V4th
Sisskin V, 2006, PERSPECTIVES FLUENCY, V16, P12
Sisskin V, 2007, 10 ANN INT STUTT AW
STANSFIELD J, 1995, J FLUENCY DISORD, V20, P1, DOI 10.1016/0094-730X(93)00001-V
VanBorsel J, 1996, J FLUENCY DISORD, V21, P137, DOI 10.1016/0094-730X(96)00011-3
Van Borsel J, 2005, FOLIA PHONIATR LOGO, V57, P148, DOI 10.1159/000084135
Yaruss SJ, 2010, OVERALL ASSESSMENT S
NR 35
TC 0
Z9 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0734-0478
EI 1098-9056
J9 SEMIN SPEECH LANG
JI Semin. Speech Lang.
PD MAY
PY 2014
VL 35
IS 2
DI 10.1055/s-0034-1371757
PG 9
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AI9XW
UT WOS:000337301600005
PM 24782276
ER
PT J
AU Lewis, JD
Evans, AC
Pruett, JR
Botteron, K
Zwaigenbaum, L
Estes, A
Gerig, G
Collins, L
Kostopoulos, P
McKinstry, R
Dager, S
Paterson, S
Schultz, RT
Styner, M
Hazlett, H
Piven, J
AF Lewis, J. D.
Evans, A. C.
Pruett, J. R.
Botteron, K.
Zwaigenbaum, L.
Estes, A.
Gerig, G.
Collins, L.
Kostopoulos, P.
McKinstry, R.
Dager, S.
Paterson, S.
Schultz, R. T.
Styner, M.
Hazlett, H.
Piven, J.
CA IBIS Network
TI Network inefficiencies in autism spectrum disorder at 24 months
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; CEREBRAL-BLOOD-FLOW; FUSIFORM FACE AREA;
CHILDHOOD AUTISM; CORPUS-CALLOSUM; TEMPORAL-LOBE; WHITE-MATTER;
SMALL-WORLD; FRONTAL-CORTEX; BRAIN NETWORK
AB Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral symptoms that emerge during the first years of life. Associated with these symptoms are differences in the structure of a wide array of brain regions, and in the connectivity between these regions. However, the use of cohorts with large age variability and participants past the generally recognized age of onset of the defining behaviors means that many of the reported abnormalities may be a result of cascade effects of developmentally earlier deviations. This study assessed differences in connectivity in ASD at the age at which the defining behaviors first become clear. There were 113 24-month-old participants at high risk for ASD, 31 of whom were classified as ASD, and 23 typically developing 24-month-old participants at low risk for ASD. Utilizing diffusion data to obtain measures of the length and strength of connections between anatomical regions, we performed an analysis of network efficiency. Our results showed significantly decreased local and global efficiency over temporal, parietal and occipital lobes in high-risk infants classified as ASD, relative to both low-and high-risk infants not classified as ASD. The frontal lobes showed only a reduction in global efficiency in Broca's area. In addition, these same regions showed an inverse relation between efficiency and symptom severity across the high-risk infants. The results suggest delay or deficits in infants with ASD in the optimization of both local and global aspects of network structure in regions involved in processing auditory and visual stimuli, language and nonlinguistic social stimuli.
C1 [Lewis, J. D.; Evans, A. C.; Collins, L.; Kostopoulos, P.] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada.
[Pruett, J. R.; Botteron, K.; McKinstry, R.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Zwaigenbaum, L.] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.
[Estes, A.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
[Gerig, G.] Univ Utah, Sci Comp & Imaging Inst, Salt Lake City, UT USA.
[Dager, S.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
[Paterson, S.; Schultz, R. T.] Univ Penn, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Styner, M.] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA.
[Styner, M.; Hazlett, H.; Piven, J.] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
RP Lewis, JD (reprint author), McGill Univ, Montreal Neurol Inst, 3801 Univ,WB208, Montreal, PQ H3A 2B4, Canada.
EM jlewis@bic.mni.mcgill.ca
FU NIH Autism Center of Excellence grant [HD055741]; Autism Speaks; Simons
Foundation; Canada Foundation for Innovation (CFI); Government of
Quebec; National Science and Engineering Research Council (NSERC); Fonds
Quebecois de Recherche sur la Nature et les Technologies (FQRNT)
FX This work was supported by an NIH Autism Center of Excellence grant (a
longitudinal MRI study of infants at risk for autism, NIH, R01
Supplement, 2009-2013, NIMH and NICHD #HD055741 to Principal
Investigator JP) and funding from Autism Speaks, the Simons Foundation,
the Canada Foundation for Innovation (CFI), the Government of Quebec,
the National Science and Engineering Research Council (NSERC) and the
Fonds Quebecois de Recherche sur la Nature et les Technologies (FQRNT).
CR Achard S, 2007, PLOS COMPUT BIOL, V3, P174, DOI 10.1371/journal.pcbi.0030017
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
Behrens TEJ, 2003, NAT NEUROSCI, V6, P750, DOI 10.1038/nn1075
Behrens TEJ, 2007, NEUROIMAGE, V34, P144, DOI 10.1016/j.neuroimage.2006.09.018
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500
Bullmore ET, 2012, NAT REV NEUROSCI, V13, P336, DOI 10.1038/nrn3214
Burroni L, 2008, NUCL MED COMMUN, V29, P150
Caramanos Z, 2010, NEUROIMAGE, V49, P1601, DOI 10.1016/j.neuroimage.2009.08.008
Chugani HT, 1996, ANN NEUROL, V39, P643, DOI 10.1002/ana.410390514
COLLINS DL, 1994, J COMPUT ASSIST TOMO, V18, P192
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794
Elison JT, 2013, AM J PSYCHIAT, V170, P899, DOI 10.1176/appi.ajp.2012.12091150
Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x
Elsabbagh M, 2013, BIOL PSYCHIAT, V74, P189, DOI 10.1016/j.biopsych.2012.11.030
Eyler LT, 2012, BRAIN, V135, P949, DOI 10.1093/brain/awr364
Fan Y, 2011, NEUROIMAGE, V54, P1862, DOI 10.1016/j.neuroimage.2010.07.025
Frazier TW, 2009, BIOL PSYCHIAT, V66, P935, DOI 10.1016/j.biopsych.2009.07.022
Gallos LK, 2012, P NATL ACAD SCI USA, V109, P2825, DOI 10.1073/pnas.1106612109
Georgiades S, 2013, JAMA PSYCHIAT, V70, P42, DOI 10.1001/2013.jamapsychiatry.1
Gong GL, 2009, CEREB CORTEX, V19, P524, DOI 10.1093/cercor/bhn102
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Gouttard S, 2008, LECT NOTES COMPUT SC, V5242, P263, DOI 10.1007/978-3-540-85990-1_32
Guiraud JA, 2011, NEUROREPORT, V22, P845, DOI 10.1097/WNR.0b013e32834c0bec
Guiraud JA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036428
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
Jenkinson M, 2001, MED IMAGE ANAL, V5, P143, DOI 10.1016/S1361-8415(01)00036-6
Johnson MH, 2005, DEV PSYCHOPATHOL, V17, P599, DOI 10.1017/S0954579405050297
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Karmiloff-Smith A, 1998, TRENDS COGN SCI, V2, P389, DOI 10.1016/S1364-6613(98)01230-3
Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
Khundrakpam BS, 2013, CEREB CORTEX, V23, P2072, DOI 10.1093/cercor/bhs187
Kim JS, 2005, NEUROIMAGE, V27, P210, DOI 10.1016/j.neuroimage.2005.03.036
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Lainhart JE, 1997, J AM ACAD CHILD PSY, V36, P282, DOI 10.1097/00004583-199702000-00019
Latora V, 2001, PHYS REV LETT, V87, DOI 10.1103/PhysRevLett.87.198701
Latora V, 2003, EUR PHYS J B, V32, P249, DOI 10.1140/epjb/e2003-00095-5
Lewis JD, 2008, DEVELOPMENTAL SCI, V11, P135, DOI 10.1111/j.1467-7687.2007.00634.x
Lewis JD, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00845
Li H., 2012, HUM BRAIN MAPP, DOI [10.1002/hbm.22185, DOI 10.1002/HBM.22185]
Liu YN, 2011, NEUROPSYCHOLOGIA, V49, P2105, DOI 10.1016/j.neuropsychologia.2011.04.005
Liu Z, 2010, P SPIE MED IMAGING 2
Lyttelton O, 2007, NEUROIMAGE, V34, P1535, DOI 10.1016/j.neuroimage.2006.10.041
Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332
Meresse IG, 2005, ANN NEUROL, V58, P466, DOI 10.1002/ana.20597
Messinger D, 2013, J AM ACAD CHILD PSY, V52, P300, DOI 10.1016/j.jaac.2012.12.011
Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076
Ohnishi T, 2000, BRAIN, V123, P1838, DOI 10.1093/brain/123.9.1838
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Redcay E, 2008, NEUROSCI BIOBEHAV R, V32, P123, DOI 10.1016/j.neubiorev.2007.06.004
Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
Rubinov M, 2010, NEUROIMAGE, V52, P1059, DOI 10.1016/j.neuroimage.2009.10.003
Rudie JD, 2013, NEUROIMAGE-CLIN, V2, P79, DOI 10.1016/j.nicl.2012.11.006
RUTTER M, 1978, J AUTISM CHILD SCHIZ, V8, P139, DOI 10.1007/BF01537863
Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Shih P, 2010, NEUROPSYCHOLOGIA, V48, P2931, DOI 10.1016/j.neuropsychologia.2010.05.035
Sled JG, 1998, IEEE T MED IMAGING, V17, P87, DOI 10.1109/42.668698
TAGERFLUSBERG H, 1981, J AUTISM DEV DISORD, V11, P45, DOI 10.1007/BF01531340
Tohka J, 2004, NEUROIMAGE, V23, P84, DOI 10.1016/j.neuroimage.2004.05.007
Turner Katherine C, 2006, Behav Brain Funct, V2, P34, DOI 10.1186/1744-9081-2-34
Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
Vissers ME, 2011, NEUROSCI BIOBEHAV R, V36, P604, DOI DOI 10.1016/J.NEUBI0REV.2011.09.003
Watts DJ, 1998, NATURE, V393, P440, DOI 10.1038/30918
Welchew DE, 2005, BIOL PSYCHIAT, V57, P991, DOI 10.1016/j.biopsych.2005.01.028
Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002
Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
Zijdenbos AP, 2002, IEEE T MED IMAGING, V21, P1280, DOI 10.1109/TMI.2002.806283
Zilbovicius M, 2000, AM J PSYCHIAT, V157, P1988, DOI 10.1176/appi.ajp.157.12.1988
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 84
TC 2
Z9 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD MAY
PY 2014
VL 4
AR e388
DI 10.1038/tp.2014.24
PG 11
WC Psychiatry
SC Psychiatry
GA AJ2RX
UT WOS:000337509500001
PM 24802306
ER
PT J
AU Rakap, S
Snyder, P
Pasia, C
AF Rakap, Salih
Snyder, Patricia
Pasia, Cathleen
TI Comparison of Nonoverlap Methods for Identifying Treatment Effect in
Single-Subject Experimental Research
SO BEHAVIORAL DISORDERS
LA English
DT Article
ID EFFECT SIZES; QUANTITATIVE SYNTHESIS; CHALLENGING BEHAVIOR; VISUAL
INSPECTION; DESIGNS; METAANALYSIS; CHILDREN; AUTISM; INSTRUCTION;
PERCENTAGE
AB Debate is occurring about which result interpretation aides focused on examining the experimental effect should be used in single-subject experimental research. In this study, we examined seven nonoverlap methods and compared results using each method to judgments of two visual analysts. The data sources for the present study were 36 studies focused on naturalistic instruction interventions for young children with disabilities and 222 A-B graphs available in these studies. Two visual analysts made judgments about whether a functional relationship was evident in 222 A-B graphs. A graphing program was used to derive data for calculating each of the nonoverlap methods. Results showed that (a) estimates of experimental effect varied across the seven nonoverlap methods and (b) nonoverlap methods corresponding most closely with visual analysts' judgments of a change in data patterns differed from the nonoverlap methods that corresponded most closely with visual analysts' judgments of no change in data patterns. Based on findings from this study, we discuss considerations for selection and use of nonoverlap methods as result interpretation aides in single-subject experimental research and offer directions for future research.
C1 [Rakap, Salih; Snyder, Patricia; Pasia, Cathleen] Univ Florida, Gainesville, FL 32611 USA.
RP Rakap, S (reprint author), Univ Florida, Ctr Excellence Early Childhood Studies, Gainesville, FL 32611 USA.
EM salihrakap@ufl.edu
CR ALLISON DB, 1993, BEHAV RES THER, V31, P621, DOI 10.1016/0005-7967(93)90115-B
American Psychological Association, 2010, PUBL MAN AM PSYCH AS, V6th
BAER DM, 1977, J APPL BEHAV ANAL, V10, P167, DOI 10.1901/jaba.1977.10-167
BAMBARA LM, 1988, J ASSOC PERS SEVERE, V13, P8
Barrett P. T., 2011, NOTE COHENS OVERLAPP
Beretvas SN, 2008, EVIDENCE BASED COMMU, V2, P129, DOI DOI 10.1080/17489530802446302
Biosoft, 2004, UNGR WIND VERS 5 0
Campbell JM, 2004, BEHAV MODIF, V28, P234, DOI 10.1177/0145445503259264
CENTER BA, 1985, J SPEC EDUC, V19, P387
Chiara L, 1995, J EARLY INTERVENTION, V19, P203
Cohen R., 1988, STAT POWER ANAL BEHA
DEPROSPERO A, 1979, J APPL BEHAV ANAL, V12, P573, DOI 10.1901/jaba.1979.12-573
Ferron J, 2002, J EXP EDUC, V70, P165
Grissom R., 2005, EFFECT SIZES RES BRO
Hinton P. R., 2004, STAT EXPLAINED GUIDE
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Kazdin A. E., 1982, SINGLE CASE RES DESI
Kokina A, 2010, J AUTISM DEV DISORD, V40, P812, DOI 10.1007/s10803-009-0931-0
Kratochwill T. R., 2010, SINGLE CASE DESIGNS
Laushey KM, 2009, J AUTISM DEV DISORD, V39, P1435, DOI 10.1007/s10803-009-0757-9
Lequia J, 2012, RES AUTISM SPECT DIS, V6, P480, DOI 10.1016/j.rasd.2011.07.008
Lipsey M. W., 2001, PRACTICAL METAANALYS
Ma HH, 2006, BEHAV MODIF, V30, P598, DOI 10.1177/0145445504272974
Maggin DM, 2013, REM SPEC EDUC, V34, P44, DOI 10.1177/0741932511435176
Mason RA, 2013, RES AUTISM SPECT DIS, V7, P120, DOI 10.1016/j.rasd.2012.08.003
OTTENBACHER KJ, 1990, MENT RETARD, V28, P283
PARK HS, 1990, J EXP EDUC, V58, P311
Parker R. I., 2007, PAIRWISE DATA OVERLA
Parker RI, 2011, BEHAV THER, V42, P284, DOI 10.1016/j.beth.2010.08.006
Parker RI, 2011, BEHAV MODIF, V35, P303, DOI 10.1177/0145445511399147
Parker RI, 2005, SCHOOL PSYCHOL REV, V34, P116
Parker RI, 2007, BEHAV MODIF, V31, P919, DOI 10.1177/0145445507303452
Parker RI, 2007, J SPEC EDUC, V40, P194, DOI 10.1177/00224669070400040101
Parker RI, 2003, BEHAV THER, V34, P189, DOI 10.1016/S0005-7894(03)80013-8
Parker RI, 2009, EXCEPT CHILDREN, V75, P135
Parker RI, 2009, BEHAV THER, V40, P357, DOI 10.1016/j.beth.2008.10.006
Parsonson B. S., 1986, RES METHODS APPL BEH, P157
Rispoli MJ, 2011, EDUC TRAIN AUTISM DE, V46, P607
Rogers LA, 2008, J EDUC PSYCHOL, V100, P879, DOI 10.1037/0022-0663.100.4.879
ROSENTHAL R, 1979, PSYCHOL BULL, V86, P638, DOI 10.1037//0033-2909.86.3.638
SALZBERG CL, 1987, REM SPEC EDUC, V8, P43
Schneider N., 2008, EVIDENCE BASED COMMU, V2, P152, DOI DOI 10.1080/17489530802505396
Scruggs TE, 2013, REM SPEC EDUC, V34, P9, DOI 10.1177/0741932512440730
Scruggs TE, 1998, BEHAV MODIF, V22, P221, DOI 10.1177/01454455980223001
SCRUGGS TE, 1987, REM SPEC EDUC, V8, P24
Shadish W. R., 2008, EVIDENCE BASED COMMU, V2, P188, DOI DOI 10.1080/17489530802581603
Shadish W. R., 2007, INFORM FEDERAL POLIC, P95, DOI DOI 10.1002/EV.217
Shadish WR, 2009, BEHAV RES METHODS, V41, P177, DOI 10.3758/BRM.41.1.177
Snyder P, 2014, NATURALISTIC I UNPUB
Trembath D, 2009, J INTELLECT DEV DIS, V34, P173, DOI 10.1080/13668250902845210
Van den Noortgate W, 2003, BEHAV RES METH INS C, V35, P1
Van Rie GL, 2009, RES AUTISM SPECT DIS, V3, P783, DOI 10.1016/j.rasd.2009.03.001
White O. R., 1980, EXCEPTIONAL TEACHING
Wolery M., 2008, C RES INN EARL INT S
WOLERY M, 1982, PHYS THER, V62, P445
Wolery M, 2010, J SPEC EDUC, V44, P18, DOI 10.1177/0022466908328009
NR 56
TC 0
Z9 0
PU COUNCIL CHILDREN BEHAVIORAL DISORDERS
PI ARLINGTON
PA COUNCIL EXCEPTIONAL CHILDREN, 1110 NORTH GLEBE RD, ARLINGTON, VA
22201-5704 USA
SN 0198-7429
EI 2163-5307
J9 BEHAV DISORDERS
JI Behav. Disord.
PD MAY
PY 2014
VL 39
IS 3
BP 128
EP 145
PG 18
WC Psychology, Clinical; Psychology, Educational
SC Psychology
GA AI7FR
UT WOS:000337050600002
ER
PT J
AU Reid, AK
Folks, N
Hardy, J
AF Reid, Alliston K.
Folks, Nathan
Hardy, Jordan
TI On the dynamics of stimulus control during guided skill learning in
nonhumans
SO BEHAVIOURAL PROCESSES
LA English
DT Article
DE Autonomy; Expertise; Motor skill; Prompt dependence; Skill learning;
Stimulus control
ID REINFORCEMENT CONTINGENCIES; GUIDING CUES; DISCRIMINATION; EXPERTISE;
BEHAVIOR; AUTISM; MEMORY; DOGS; RATS
AB This study measured skill acquisition in the presence and absence of guiding cues in pigeons.
It asked whether the speed of development of autonomy for the motor skill is influenced by the difficulty level of two guiding-cue conditions requiring the same left-right response sequence. The Follow-Red condition required a simple go, no-go discrimination (red = S+, green = S-), whereas the Red-Green condition was a more difficult simultaneous chain requiring sensitivity to the serial order of key colors (red = S+, green = S- for the first peck, but red = S-, green = S+ for the second peck). Pigeons exposed to the difficult Red-Green condition displayed significantly higher accuracy levels during no-cues conditions earlier in training than those exposed to the easier Follow-Red condition. A modified Power Law of Practice was used to evaluate the null hypothesis that autonomy develops equally in explicit guiding-cues conditions and no-cues conditions. This hypothesis was retained in the Follow-Red condition but rejected in the Red-Green condition. Practice completing the response sequence in the Follow-Red and no-cues conditions both contributed equally to autonomy. Autonomy developed faster in the Red,Green group in both conditions, and it developed unexpectedly rapidly during the second guiding-cues condition, implying the involvement of a second process for the Red-Green condition. We discuss the implications of these results to prompt dependence in children with learning disabilities, the transfer of stimulus control, and potential behavioral interventions. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Reid, Alliston K.; Folks, Nathan; Hardy, Jordan] Wofford Coll, Dept Psychol, Spartanburg, SC 29303 USA.
RP Reid, AK (reprint author), Wofford Coll, Dept Psychol, 429 North Church St, Spartanburg, SC 29303 USA.
EM reidak@wofford.edu
CR Clark KM, 2004, J APPL BEHAV ANAL, V37, P503, DOI 10.1901/jaba.2004.37-503
CRAIK FIM, 1972, J VERB LEARN VERB BE, V11, P671, DOI 10.1016/S0022-5371(72)80001-X
Ebbinghaus H., 1885, MEMORY CONTRIBUTION
Erricsson K. A., 1993, PSYCHOL REV, V100, P363
Fitts P., 1967, HUMAN PERFORMANCE
Fox A. E., PSYCHOL REC IN PRESS
HEARST E, 1991, AM SCI, V79, P432
Helton WS, 2007, J EXP PSYCHOL-APPL, V13, P171, DOI 10.1037/1076-898X.13.3.171
Helton WS, 2004, J GEN PSYCHOL, V131, P86, DOI 10.3200/GENP.131.1.86-96
Helton WS, 2007, J GEN PSYCHOL, V134, P247, DOI 10.3200/GENP.134.2.247-258
Helton WS, 2005, ANIM COGN, V8, P67, DOI 10.1007/s10071-004-0234-y
Karsten AM, 2009, J APPL BEHAV ANAL, V42, P327, DOI 10.1901/jaba.2009.42-327
LATTAL KA, 1975, J EXP ANAL BEHAV, V23, P241, DOI 10.1901/jeab.1975.23-241
MacDuff G. S., 2001, MAKING DIFFERENCE BE, P37
Proctor RW, 2006, CAMBRIDGE HANDBOOK OF EXPERTISE AND EXPERT PERFORMANCE, P265
Reid AK, 2010, BEHAV PROCESS, V84, P511, DOI 10.1016/j.beproc.2010.01.001
Reid AK, 2013, LEARN BEHAV, V41, P402, DOI 10.3758/s13420-013-0115-9
Reid AK, 2013, LEARN BEHAV, V41, P455, DOI 10.3758/s13420-013-0121-y
Reid AK, 2009, J EXP PSYCHOL ANIM B, V35, P293, DOI 10.1037/a0013926
Rosenbloom P. S., 1981, COGNITIVE SKILLS THE, P1
Rosenbloom P. S., 2006, TUTORIALS QUANTITATI, V2, P43
SHIMP CP, 1981, J EXP ANAL BEHAV, V36, P303, DOI 10.1901/jeab.1981.36-303
SHIMP CP, 1982, ANIM LEARN BEHAV, V10, P358, DOI 10.3758/BF03213722
TERRACE HS, 1963, J EXP ANAL BEHAV, V6, P1, DOI 10.1901/jeab.1963.6-1
Terrace HS, 1984, QUANTITATIVE ANAL BE, V4, P115
Terrace H.S., 2005, COMPARATIVE COGNITIO, P481
TERRACE HS, 1963, J EXP ANAL BEHAV, V6, P223, DOI 10.1901/jeab.1963.6-223
TOUCHETTE PE, 1984, J APPL BEHAV ANAL, V17, P175, DOI 10.1901/jaba.1984.17-175
TOUCHETT.PE, 1971, J EXP ANAL BEHAV, V15, P347, DOI 10.1901/jeab.1971.15-347
NR 29
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0376-6357
EI 1872-8308
J9 BEHAV PROCESS
JI Behav. Processes
PD MAY
PY 2014
VL 104
SI SI
BP 72
EP 83
DI 10.1016/j.beproc.2014.01.017
PG 12
WC Psychology, Biological; Behavioral Sciences; Zoology
SC Psychology; Behavioral Sciences; Zoology
GA AI4HK
UT WOS:000336826100010
PM 24468214
ER
PT J
AU Suraev, AS
Bowen, MT
Ali, SO
Hicks, C
Ramos, L
McGregor, LS
AF Suraev, Anastasia S.
Bowen, Michael T.
Ali, Sinan O.
Hicks, Callum
Ramos, Linnet
McGregor, Lain S.
TI Adolescent exposure to oxytocin, but not the selective oxytocin receptor
agonist TGOT, increases social behavior and plasma oxytocin in adulthood
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Oxytocin; TGOT; Social behavior; Social play; Anxiety; EIA
ID AUTISM SPECTRUM DISORDERS; V1A VASOPRESSIN RECEPTOR; ANXIETY-RELATED
BEHAVIOR; MALE-RATS; INTRANASAL OXYTOCIN; ENZYME-IMMUNOASSAY; FOS
EXPRESSION; BRAIN; MICE; SYSTEM
AB There are indications that exposing adolescent rodents to oxytocin (OT) may have positive "trait-changing" effects resulting in increased sociability and decreased anxiety that last well beyond acute drug exposure and into adulthood. Such findings may have relevance to the utility of OT in producing sustained beneficial effects in human psychiatric conditions. The present study further examined these effects using an intermittent regime of OT exposure in adolescence, and using Long Evans rats, that are generally more sensitive to the acute prosocial effects of OT. As OT has substantial affinity for the vasopressin Via receptor (V1aR) in addition to the oxytocin receptor (OTR), we examined whether a more selective peptidergic OTR agonist - [Thr4, Gly7]-oxytocin (TGOT) - would have similar lasting effects on behavior. Male Long Evans rats received OT or TGOT (0.5-1 mg/kg, intraperitoneal), once every three days, for a total of 10 doses during adolescence (postnatal day (PND) 28-55). Social and anxiety-related behaviors were assessed during acute administration as well as later in adulthood (from PND 70 onwards). OT produced greater acute behavioral effects than TGOT, including an inhibition of social play and reduced rearing, most likely reflecting primary sedative effects. In adulthood, OT but not TGOT pretreated rats displayed lasting increases in social interaction, accompanied by an enduring increase in plasma OT. These findings confirm lasting behavioral and neuroendocrine effects of adolescent OT exposure. However, the absence of such effects with TGOT suggests possible involvement of the V1aR as well as the OTR in this example of developmental neuroplasticity. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Suraev, Anastasia S.; Bowen, Michael T.; Ali, Sinan O.; Hicks, Callum; Ramos, Linnet; McGregor, Lain S.] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
RP McGregor, LS (reprint author), Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
EM iain.mcgregor@sydney.edu.au
FU National Health and Medical Research Council (NHMRC); Australian
Research Council (ARC)
FX This study was supported by research funding to Professor lain McGregor
from the National Health and Medical Research Council (NHMRC) and the
Australian Research Council (ARC). Professor McGregor is an ARC
Australian Professorial Fellow and NHMRC Principal Research Fellow.
CR Bales KL, 2012, HORM BEHAV, V61, P313, DOI 10.1016/j.yhbeh.2011.12.013
Bielsky IF, 2005, NEURON, V47, P503, DOI 10.1016/j.neuron.2005.06.031
Bowen MT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027237
Braida D, 2012, PSYCHOPHARMACOLOGY, V220, P319, DOI 10.1007/s00213-011-2482-2
Busnelli M., 2013, J PHARM EXP THER
Carson DS, 2010, ADDICT BIOL, V15, P448, DOI 10.1111/j.1369-1600.2010.00247.x
Egashira N, 2007, BEHAV BRAIN RES, V178, P123, DOI 10.1016/j.bbr.2006.12.009
ELANDS J, 1988, AM J PHYSIOL, V254, pE31
Grippo AJ, 2009, PSYCHONEUROENDOCRINO, V34, P1542, DOI 10.1016/j.psyneuen.2009.05.017
Hicks C, 2012, J NEUROENDOCRINOL, V24, P1012, DOI 10.1111/j.1365-2826.2012.02311.x
Huang H., 2013, NEUROPSYCHOPHARMACOL
Kagerbauer SM, 2013, J NEUROENDOCRINOL, V25, P668, DOI 10.1111/jne.12038
Kosaka H, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-110
Kramer KM, 2004, CAN J ZOOL, V82, P1194, DOI 10.1139/Z04-098
Landgraf R, 2003, EUR J NEUROSCI, V18, P403, DOI 10.1046/j.1460-9568.2003.02750.x
Lee PR, 2007, BRAIN RES, V1156, P152, DOI 10.1016/j.brainres.2007.04.042
Lever C, 2006, REV NEUROSCIENCE, V17, P111
LOWBRIDGE J, 1977, J MED CHEM, V20, P120, DOI 10.1021/jm00211a025
Lukas M, 2011, NEUROPSYCHOPHARMACOL, V36, P2159, DOI 10.1038/npp.2011.95
Lukas M, 2010, NEUROPHARMACOLOGY, V58, P78, DOI 10.1016/j.neuropharm.2009.06.020
Manning M, 2012, J NEUROENDOCRINOL, V24, P609, DOI 10.1111/j.1365-2826.2012.02303.x
McCullough ME, 2013, NEUROSCI BIOBEHAV R, V37, P1485, DOI 10.1016/j.neubiorev.2013.04.018
McEwen Barbara B, 2004, Adv Pharmacol, V50, P1
McGregor IS, 2013, OXYTOCIN, VASOPRESSIN AND RELATED PEPTIDES IN THE REGULATION OF BEHAVIOR, P270
Motbey CP, 2012, ADDICT BIOL, V17, P409, DOI 10.1111/j.1369-1600.2011.00384.x
Moura PJ, 2010, BRAZ J MED BIOL RES, V43, P663, DOI 10.1590/S0100-879X2010007500047
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
Neumann ID, 2013, PSYCHONEUROENDOCRINO, V38, P1985, DOI 10.1016/j.psyneuen.2013.03.003
Neumann ID, 2002, PROG BRAIN RES, V139, P147
Neumann ID, 2009, FRONT NEUROENDOCRIN, V30, P483, DOI 10.1016/j.yfrne.2009.04.012
Pellis SM, 2007, CURR DIR PSYCHOL SCI, V16, P95, DOI 10.1111/j.1467-8721.2007.00483.x
Petersson M, 1999, NEUROSCI LETT, V264, P41, DOI 10.1016/S0304-3940(99)00159-7
Petersson M, 1996, PHYSIOL BEHAV, V60, P1311
Ramos L, 2013, NEUROPSYCHOPHARMACOL, V38, P2249, DOI 10.1038/npp.2013.125
Rault JL, 2013, PHYSIOL BEHAV, V112, P40, DOI 10.1016/j.physbeh.2013.02.007
Sala M, 2011, BIOL PSYCHIAT, V69, P875, DOI 10.1016/j.biopsych.2010.12.022
Sala M., 2012, J NEUROENDOCRINOL, V24, P107
Spear LP, 2000, NEUROSCI BIOBEHAV R, V24, P417, DOI 10.1016/S0149-7634(00)00014-2
Szeto A, 2011, PSYCHOSOM MED, V73, P393, DOI 10.1097/PSY.0b013e31821df0c2
Tachibana M, 2013, J CHILD ADOL PSYCHOP, V23, P123, DOI 10.1089/cap.2012.0048
Teng BL, 2013, NEUROPHARMACOLOGY, V72, P187, DOI 10.1016/j.neuropharm.2013.04.038
Terrillon S, 2002, J MED CHEM, V45, P2579, DOI 10.1021/jm010526+
THEODOSIS DT, 1986, NATURE, V322, P738, DOI 10.1038/322738a0
Theodosis DT, 2002, FRONT NEUROENDOCRIN, V23, P101, DOI 10.1006/frne.2001.0226
Trezza V, 2010, TRENDS PHARMACOL SCI, V31, P463, DOI 10.1016/j.tips.2010.06.008
Trezza V, 2008, EUR NEUROPSYCHOPHARM, V18, P519, DOI 10.1016/j.euroneuro.2008.03.001
UVNASMOBERG K, 1994, PHARMACOL BIOCHEM BE, V49, P101, DOI 10.1016/0091-3057(94)90462-6
UVNASMOBERG K, 1992, ACTA PHYSIOL SCAND, V144, P487, DOI 10.1111/j.1748-1716.1992.tb09327.x
Uvnas-Moberg K, 1998, NEWS PHYSIOL SCI, V13, P22
Veenema AH, 2013, PSYCHONEUROENDOCRINO, V38, P2554, DOI 10.1016/j.psyneuen.2013.06.002
Windle RJ, 1997, ENDOCRINOLOGY, V138, P2829, DOI 10.1210/en.138.7.2829
WITT DM, 1992, PHARMACOL BIOCHEM BE, V43, P855, DOI 10.1016/0091-3057(92)90418-F
Young LJ, 2011, NEUROPSYCHOPHARMACOL, V36, P2151, DOI 10.1038/npp.2011.124
Zhong SF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051095
NR 54
TC 4
Z9 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD MAY
PY 2014
VL 65
IS 5
BP 488
EP 496
DI 10.1016/j.yhbeh.2014.03.002
PG 9
WC Behavioral Sciences; Endocrinology & Metabolism
SC Behavioral Sciences; Endocrinology & Metabolism
GA AI5DG
UT WOS:000336885000007
PM 24631584
ER
PT J
AU Gabis, LV
Pomeroy, J
AF Gabis, Lidia V.
Pomeroy, John
TI An Etiologic Classification of Autism Spectrum Disorders
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE pervasive developmental disorders; autism spectrum disorders (ASD);
regression; classification; children; epidemiology
ID RISK-FACTORS; CHILDREN; POPULATION; SUBTYPES; COMPLEX
AB Background: Autism spectrum disorders (AS) represent a common phenotype related to Multiple etiologies, such as genetic, brain injury (e.g., prematurity), environmental (e.g., viral, toxic), multiple or unknown causes.
Objectives: To devise a clinical classification of children diagnosed with ASP according to etiologic workup.
Methods: Children diagnosed with ASD (n=436) from two databases were divided into groups of symptomatic, cryptogenic or idiopathic, and variables within each database and diagnostic category were compared.
Results: By analyzing the two separate databases, 5.4% of the children were classified as symptomatic, 27% as cryptogenic and 67.75% as idiopathic. Among other findings, the entire symptomatic group demonstrated language delays, but almost none showed evidence for regression. Our results indicate similarities between the idiopathic and cryptogenic subgroups in most of the examined variables, and mutual differences from the symptomatic subgroup. The similarities between the first two subgroups Support prior evidence that most perinatal factors and minor physical anomalies do not contribute to the development of core symptoms of autism.
Conclusions: Differences in gender and clinical and diagnostic features were found when etiology was used to create Subtypes of ASD. This classification could have heuristic importance in the search for an autism gene(s).
C1 [Gabis, Lidia V.] Chaim Sheba Med Ctr, Weinberg Dev Ctr, IL-52621 Tel Hashomer, Israel.
[Gabis, Lidia V.] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
[Gabis, Lidia V.] Ono Acad Coll, Kiryat Ono, Israel.
[Pomeroy, John] Cody Ctr Autism, Stony Brook, NY USA.
RP Gabis, LV (reprint author), Chaim Sheba Med Ctr, Weinberg Dev Ctr, IL-52621 Tel Hashomer, Israel.
EM lidiagabis@gmail.com
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Badawi N, 2006, DEV MED CHILD NEUROL, V48, P85, DOI 10.1017/S001216220600020X
Baieli S, 2003, J AUTISM DEV DISORD, V33, P201, DOI 10.1023/A:1022999712639
Canitano R, 2007, AUTISM, V11, P19, DOI 10.1177/1362361307070992
Capone GT, 2005, AM J MED GENET A, V134A, P373, DOI 10.1002/ajmg.a.30622
Davidovitch M, 2001, ISRAEL MED ASSOC J, V3, P188
Edwards J C, 2001, CNS Spectr, V6, P750
Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3
Gal G, 2012, J AUTISM DEV DISORD, V42, P428, DOI 10.1007/s10803-011-1252-7
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Gorczyca P, 2009, INT M AUT RES IMFAR
Indredavik MS, 2005, PEDIATR NEUROL, V33, P259, DOI 10.1016/j.pediatrneurol.2005.05.002
Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kau ASM, 2004, AM J MED GENET A, V126A, P9, DOI 10.1002/ajmg.a.20218
Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x
Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
Miles JH, 2000, AM J MED GENET, V91, P245, DOI 10.1002/(SICI)1096-8628(20000410)91:4<245::AID-AJMG1>3.0.CO;2-2
Miles JH, 2005, AM J MED GENET A, V135A, P171, DOI 10.1002/ajmg.a.30590
Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
Piggot J, 2009, NEUROSCIENCE, V164, P247, DOI 10.1016/j.neuroscience.2009.05.054
Skuse DH, 2007, TRENDS GENET, V23, P387, DOI 10.1016/j.tig.2007.06.003
Yamashita Y, 2003, J AUTISM DEV DISORD, V33, P455, DOI 10.1023/A:1025023131029
NR 24
TC 0
Z9 0
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD MAY
PY 2014
VL 16
IS 5
BP 295
EP 298
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA AI5CZ
UT WOS:000336884300008
PM 24979834
ER
PT J
AU Berko, ER
Suzuki, M
Beren, F
Lemetre, C
Alaimo, CM
Calder, RB
Ballaban-Gil, K
Gounder, B
Kampf, K
Kirschen, J
Maqbool, SB
Momin, Z
Reynolds, DM
Russo, N
Shulman, L
Stasiek, E
Tozour, J
Valicenti-McDermott, M
Wang, SL
Abrahams, BS
Hargitai, J
Inbar, D
Zhang, ZD
Buxbaum, JD
Molholm, S
Foxe, JJ
Marion, RW
Auton, A
Greally, JM
AF Berko, Esther R.
Suzuki, Masako
Beren, Faygel
Lemetre, Christophe
Alaimo, Christine M.
Calder, R. Brent
Ballaban-Gil, Karen
Gounder, Batya
Kampf, Kaylee
Kirschen, Jill
Maqbool, Shahina B.
Momin, Zeineen
Reynolds, David M.
Russo, Natalie
Shulman, Lisa
Stasiek, Edyta
Tozour, Jessica
Valicenti-McDermott, Maria
Wang, Shenglong
Abrahams, Brett S.
Hargitai, Joseph
Inbar, Dov
Zhang, Zhengdong
Buxbaum, Joseph D.
Molholm, Sophie
Foxe, John J.
Marion, Robert W.
Auton, Adam
Greally, John M.
TI Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum
Disorder
SO PLOS GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; COPY NUMBER VARIATION; DNA METHYLATION; GENE
PRIORITIZATION; MATERNAL AGE; R PACKAGE; NETWORK; PATTERNS; BRAIN;
PHENOTYPE
AB DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a possible mediator of environmental effects during development, encoding a cellular memory reflected by altered function of progeny cells. Advanced maternal age (AMA) is associated with an increased risk of having a child with ASD for reasons that are not understood. To explore whether AMA involves covert aneuploidy or epigenetic dysregulation leading to ASD in the offspring, we tested a homogeneous ectodermal cell type from 47 individuals with ASD compared with 48 typically developing (TD) controls born to mothers of >= 35 years, using a quantitative genome-wide DNA methylation assay. We show that DNA methylation patterns are dysregulated in ectodermal cells in these individuals, having accounted for confounding effects due to subject age, sex and ancestral haplotype. We did not find mosaic aneuploidy or copy number variability to occur at differentially-methylated regions in these subjects. Of note, the loci with distinctive DNA methylation were found at genes expressed in the brain and encoding protein products significantly enriched for interactions with those produced by known ASD-causing genes, representing a perturbation by epigenomic dysregulation of the same networks compromised by DNA mutational mechanisms. The results indicate the presence of a mosaic subpopulation of epigenetically-dysregulated, ectodermally-derived cells in subjects with ASD. The epigenetic dysregulation observed in these ASD subjects born to older mothers may be associated with aging parental gametes, environmental influences during embryogenesis or could be the consequence of mutations of the chromatin regulatory genes increasingly implicated in ASD. The results indicate that epigenetic dysregulatory mechanisms may complement and interact with DNA mutations in the pathogenesis of the disorder.
C1 [Berko, Esther R.; Suzuki, Masako; Lemetre, Christophe; Calder, R. Brent; Kirschen, Jill; Maqbool, Shahina B.; Momin, Zeineen; Reynolds, David M.; Stasiek, Edyta; Tozour, Jessica; Abrahams, Brett S.; Hargitai, Joseph; Zhang, Zhengdong; Auton, Adam; Greally, John M.] Albert Einstein Coll Med, Ctr Epigenom, Bronx, NY 10467 USA.
[Berko, Esther R.; Suzuki, Masako; Lemetre, Christophe; Calder, R. Brent; Kirschen, Jill; Maqbool, Shahina B.; Momin, Zeineen; Reynolds, David M.; Stasiek, Edyta; Tozour, Jessica; Abrahams, Brett S.; Hargitai, Joseph; Zhang, Zhengdong; Auton, Adam; Greally, John M.] Albert Einstein Coll Med, Dept Genet, Div Computat Genet, Bronx, NY 10467 USA.
[Beren, Faygel; Gounder, Batya] Yeshiva Univ, Stern Coll Women, New York, NY 10033 USA.
[Alaimo, Christine M.; Russo, Natalie; Molholm, Sophie; Foxe, John J.] Albert Einstein Coll Med, Childrens Evaluat & Rehabil Ctr, Sheryl & Daniel R Tishman Cognit Neurophysiol Lab, Bronx, NY 10467 USA.
[Alaimo, Christine M.; Russo, Natalie; Molholm, Sophie; Foxe, John J.] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA.
[Alaimo, Christine M.; Russo, Natalie; Abrahams, Brett S.; Molholm, Sophie; Foxe, John J.] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USA.
[Ballaban-Gil, Karen] Childrens Hosp Montefiore, Dept Neurol, Bronx, NY USA.
[Russo, Natalie] Syracuse Univ, Dept Psychol, Coll Arts & Sci, Syracuse, NY USA.
[Shulman, Lisa; Valicenti-McDermott, Maria; Marion, Robert W.] Albert Einstein Coll Med, Dept Pediat, Childrens Evaluat & Rehabil Ctr, Bronx, NY 10467 USA.
[Wang, Shenglong] NYU, Informat Technol Serv, New York, NY USA.
[Inbar, Dov] Schneider Childrens Med Ctr, Child Dev & Rehabil Inst, Petah Tiqwa, Israel.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, Dept Psychiat, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, Dept Neurosci, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, Dept Genet & Genom Sci, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Friedman Brain Inst, New York, NY USA.
RP Berko, ER (reprint author), Albert Einstein Coll Med, Ctr Epigenom, Bronx, NY 10467 USA.
EM john.greally@einstein.yu.edu
FU Jonas Ehrlich Charitable Foundation; Dennis Weatherstone Pre-Doctoral
Fellowship from Autism Speaks; Einstein's Medical Student Training
Program award [NIH NIGMS T32 GM007288]; Einstein's Center for
Epigenomics; Eunice Kennedy Shriver National Institute of Child Health &
Human Development [NICHD P30 HD071593]; Sheryl and Daniel R. Tishman
Charitable Foundation; Seaver Foundation
FX Support for this project was provided by the Jonas Ehrlich Charitable
Foundation, and a Dennis Weatherstone Pre-Doctoral Fellowship from
Autism Speaks to ERB. Support was also provided by Einstein's Medical
Student Training Program award (NIH NIGMS T32 GM007288), and Einstein's
Center for Epigenomics. The Human Clinical Phenotyping Core is a
facility of the Rose F. Kennedy Intellectual and Developmental
Disabilities Research Center (IDDRC) which is funded through a center
grant from the Eunice Kennedy Shriver National Institute of Child Health
& Human Development (NICHD P30 HD071593). Ongoing support of The
Cognitive Neurophysiology Laboratory is provided through a grant from
the Sheryl and Daniel R. Tishman Charitable Foundation. JDB receives
support from the Seaver Foundation. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR Abu-Amero KK, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-135
Bell JT, 2012, PLOS GENET, V8, P189, DOI 10.1371/journal.pgen.1002629
Bell JT, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-1-r10
Ben-David E, 2013, MOL PSYCHIATR, V18, P1054, DOI 10.1038/mp.2012.148
Bennetto L, 2007, BIOL PSYCHIAT, V62, P1015, DOI 10.1016/j.biopsych.2007.04.019
Boks MP, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006767
Chen CP, 2012, GENET COUNSEL, V23, P335
Chen YA, 2013, EPIGENETICS-US, V8, P203, DOI 10.4161/epi.23470
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Erten S, 2011, BIODATA MIN, V4, DOI 10.1186/1756-0381-4-19
Galle SA, 2013, PERCEPTION, V42, P341, DOI 10.1068/p7337
Garg S, 2013, DEV MED CHILD NEUROL, V55, P139, DOI 10.1111/dmcn.12043
Geeleher P, 2013, BIOINFORMATICS, V29, P1851, DOI 10.1093/bioinformatics/btt311
Gertz J, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002228
Ginsberg MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044736
Gonzalez JR, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-166
Grabrucker Andreas M, 2012, Front Psychiatry, V3, P118, DOI 10.3389/fpsyt.2012.00118
Heyn H, 2012, P NATL ACAD SCI USA, V109, P10522, DOI 10.1073/pnas.1120658109
Houseman EA, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-86
Jacobs KB, 2012, NAT GENET, V44, P651, DOI 10.1038/ng.2270
Jaffe AE, 2012, INT J EPIDEMIOL, V41, P200, DOI 10.1093/ije/dyr238
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Kostanecka A, 2012, AM J MED GENET A, V158A, P3018, DOI 10.1002/ajmg.a.35670
Ladd-Acosta C, 2014, MOL PSYCHIATR, V19, P862, DOI 10.1038/mp.2013.114
Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
Lauritsen MB, 2006, MOL PSYCHIATR, V11, P37, DOI 10.1038/sj.mp.4001754
Leek JT, 2012, BIOINFORMATICS, V28, P882, DOI 10.1093/bioinformatics/bts034
Maere S, 2005, BIOINFORMATICS, V21, P3448, DOI 10.1093/bioinformatics/bti551
Miyake K, 2012, ADV EXP MED BIOL, V724, P91, DOI 10.1007/978-1-4614-0653-2_7
Morrow EM, 2010, J AM ACAD CHILD PSY, V49, P1091, DOI 10.1016/j.jaac.2010.08.009
Muers M, 2012, NAT REV GENET, V13, P377, DOI 10.1038/nrg3248
Myers RA, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001318
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Papavassiliou P, 2009, AM J MED GENET A, V149A, P573, DOI 10.1002/ajmg.a.32729
Pellestor F, 2005, CYTOGENET GENOME RES, V111, P206, DOI 10.1159/000086891
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Poduri A, 2013, SCIENCE, V341, P43, DOI 10.1126/science.1237758
Price AL, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000519
Rakyan VK, 2011, NAT REV GENET, V12, P529, DOI 10.1038/nrg3000
Risch N, 1999, AM J HUM GENET, V65, P493, DOI 10.1086/302497
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sandin S, 2012, J AM ACAD CHILD PSY, V51, P477, DOI 10.1016/j.jaac.2012.02.018
Sarter B, 2005, HUM GENET, V117, P402, DOI 10.1007/s00439-005-1317-9
Shulha HP, 2012, ARCH GEN PSYCHIAT, V69, P314, DOI 10.1001/archgenpsychiatry.2011.151
Teschendorff AE, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008274
Gibbs JR, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000952
van Eijk KR, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-636
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Wang D, 2012, BIOINFORMATICS, V28, P729, DOI 10.1093/bioinformatics/bts013
Warde-Farley D, 2010, NUCLEIC ACIDS RES, V38, pW214, DOI 10.1093/nar/gkq537
Wong CCY, 2014, MOL PSYCHIATR, V19, P495, DOI 10.1038/mp.2013.41
Xi Yuanxin, 2009, BMC Bioinformatics, V10, P232, DOI 10.1186/1471-2105-10-232
Young MD, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-2-r14
NR 56
TC 10
Z9 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD MAY
PY 2014
VL 10
IS 5
AR e1004402
DI 10.1371/journal.pgen.1004402
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA AI8FP
UT WOS:000337145100073
PM 24875834
ER
PT J
AU Portmann, T
Yang, M
Mao, R
Panagiotakos, G
Ellegood, J
Dolen, G
Bader, PL
Grueter, BA
Goold, C
Fisher, E
Clifford, K
Rengarajan, P
Kalikhman, D
Loureiro, D
Saw, NL
Zhou, ZQ
Miller, MA
Lerch, JP
Henkelman, RM
Shamloo, M
Malenka, RC
Crawley, JN
Dolmetsch, RE
AF Portmann, Thomas
Yang, Mu
Mao, Rong
Panagiotakos, Georgia
Ellegood, Jacob
Dolen, Gul
Bader, Patrick L.
Grueter, Brad A.
Goold, Carleton
Fisher, Elaine
Clifford, Katherine
Rengarajan, Pavitra
Kalikhman, David
Loureiro, Darren
Saw, Nay L.
Zhou Zhengqui
Miller, Michael A.
Lerch, Jason P.
Henkelman, R. Mark
Shamloo, Mehrdad
Malenka, Robert C.
Crawley, Jacqueline N.
Dolmetsch, Ricardo E.
TI Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a
Mouse Model of 16p11.2 Deletion Syndrome
SO CELL REPORTS
LA English
DT Article
ID DEVELOPING CEREBRAL-CORTEX; AUTISM SPECTRUM DISORDERS; SUBTYPE-SPECIFIC
GENES; PROJECTION NEURONS; MOLECULAR SPECIFICATION; NUCLEUS-ACCUMBENS;
PYRAMIDAL NEURONS; TIMOTHY SYNDROME; CORPUS-CALLOSUM; PHENOTYPES
AB A deletion on human chromosome 16p11.2 is associated with autism spectrum disorders. We deleted the syntenic region on mouse chromosome 7F3. MRI and high-throughput single-cell transcriptomics revealed anatomical and cellular abnormalities, particularly in cortex and striatum of juvenile mutant mice (16p11(+/-)). We found elevated numbers of striatal medium spiny neurons (MSNs) expressing the dopamine D2 receptor (Drd2(+)) and fewer dopamine-sensitive (Drd1(+)) neurons in deep layers of cortex. Electrophysiological recordings of Drd2(+) MSN revealed synaptic defects, suggesting abnormal basal ganglia circuitry function in 16p11(+/-) mice. This is further supported by behavioral experiments showing hyperactivity, circling, and deficits in movement control. Strikingly, 16p11(+/-) mice showed a complete lack of habituation reminiscent of what is observed in some autistic individuals. Our findings unveil a fundamental role of genes affected by the 16p11.2 deletion in establishing the basal ganglia circuitry and provide insights in the pathophysiology of autism.
C1 [Portmann, Thomas; Mao, Rong; Panagiotakos, Georgia; Goold, Carleton; Fisher, Elaine; Clifford, Katherine; Rengarajan, Pavitra; Dolmetsch, Ricardo E.] Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA.
[Portmann, Thomas; Mao, Rong; Panagiotakos, Georgia; Bader, Patrick L.; Grueter, Brad A.; Goold, Carleton; Fisher, Elaine; Clifford, Katherine; Rengarajan, Pavitra; Shamloo, Mehrdad; Malenka, Robert C.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
[Yang, Mu; Kalikhman, David; Loureiro, Darren; Crawley, Jacqueline N.] NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA.
Stanford Univ, Neurosci Program, Stanford, CA 94305 USA.
[Ellegood, Jacob; Lerch, Jason P.; Henkelman, R. Mark] Hosp Sick Children, Mouse Imaging Ctr MICe, Toronto, ON M5T 3H7, Canada.
[Dolen, Gul] Johns Hopkins Univ, Brain Sci Inst, Dept Neurosci, Baltimore, MD 21205 USA.
[Bader, Patrick L.] Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA.
[Grueter, Brad A.; Malenka, Robert C.] Stanford Univ, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA.
[Saw, Nay L.; Zhou Zhengqui; Miller, Michael A.; Shamloo, Mehrdad] Stanford Behav & Funct Neurosci Lab, Stanford, CA 94305 USA.
[Lerch, Jason P.; Henkelman, R. Mark] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada.
[Shamloo, Mehrdad] Stanford Inst Neuroinnovat & Translat Neurosci, Stanford, CA 94305 USA.
[Dolmetsch, Ricardo E.] Novartis Inst Biomed Res, Cambridge, MA 02139 USA.
RP Dolmetsch, RE (reprint author), Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA.
EM ricardo.dolmetsch@novartis.com
RI Henkelman, Mark/F-3662-2011
FU Simons foundation SFARI grant [204340]; Nina Jauw; Swiss National
Science Foundation [PBSKP3-123434, PA00P3_134196]; NIMH Intramural
Research Program; University of California Davis MIND Institute; NIMH
[MH09064802]; NIH/NIMH [MH091160]; Institute of Neurological Disorders
and Stroke P30 center core grant [NS06937501A1]
FX We would like to thank Ulrich Elling and Josef Penninger (IMBA Vienna,
Austria) for help and advice on mouse ESC targeting, Marty Bigos of the
Stanford shared FACS facility for assistance with clone sorting, Renee
Reijo-Pera for generously providing the Biomark Instruments, Kristin L.
Sainani for advice in statistical analysis of mouse behavioral data, and
Yishan Sun for validating and providing primer pairs for the single-cell
gene expression analysis. This research was funded by the Simons
foundation SFARI grant no. 204340 (R.E.D. and J.N.C.), Nina Jauw
(R.E.D.), the Swiss National Science Foundation (nos. PBSKP3-123434 and
PA00P3_134196, T. P.), the NIMH Intramural Research Program and the
University of California Davis MIND Institute (M.Y., D.K., D.L., and
J.N.C.), an F31 NRSA from the NIMH (no. MH09064802, G.P.), a K99 from
the NIH/NIMH (no. MH091160, R.M.), and the Institute of Neurological
Disorders and Stroke P30 center core grant no. NS06937501A1 (M.S.).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Alcamo EA, 2008, NEURON, V57, P364, DOI 10.1016/j.neuron.2007.12.012
Arlotta P, 2008, J NEUROSCI, V28, P622, DOI 10.1523/JNEUROSCI.2986-07.2008
Arlotta P, 2005, NEURON, V45, P207, DOI 10.1016/j.neuron.2004.12.036
Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
Bengtsson M, 2005, GENOME RES, V15, P1388, DOI 10.1101/gr.3820805
Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
Brielmaier J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040914
Cascio CJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-9
Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22
Chen B, 2008, P NATL ACAD SCI USA, V105, P11382, DOI 10.1073/pnas.0804918105
Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
Coutellier L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046604
de Anda FC, 2012, NAT NEUROSCI, V15, P1022, DOI 10.1038/nn.3141
DeLong Mahlon, 2009, Parkinsonism Relat Disord, V15 Suppl 3, pS237, DOI 10.1016/S1353-8020(09)70822-3
Ding JB, 2012, NAT NEUROSCI, V15, P215, DOI 10.1038/nn.3003
Dolen G, 2013, NATURE, V501, P179, DOI 10.1038/nature12518
Ellegood J, 2013, NEUROIMAGE, V70, P288, DOI 10.1016/j.neuroimage.2012.12.029
Ey E, 2012, GENES BRAIN BEHAV, V11, P928, DOI 10.1111/j.1601-183X.2012.00849.x
Faizi M, 2011, NEUROBIOL DIS, V43, P397, DOI 10.1016/j.nbd.2011.04.011
Faizi M, 2012, BRAIN BEHAV, V2, P142, DOI 10.1002/brb3.41
Fernandez BA, 2010, J MED GENET, V47, P195, DOI 10.1136/jmg.2009.069369
Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
GIEDD JN, 1994, AM J PSYCHIAT, V151, P665
Gilliam M, 2011, BIOL PSYCHIAT, V69, P839, DOI 10.1016/j.biopsych.2010.11.024
Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
Gong SC, 2003, NATURE, V425, P917, DOI 10.1038/nature02033
Grueter BA, 2010, NAT NEUROSCI, V13, P1519, DOI 10.1038/nn.2685
Horev G, 2011, P NATL ACAD SCI USA, V108, P17076, DOI 10.1073/pnas.1114042108
Insel TR, 2003, PHYSIOL BEHAV, V79, P351, DOI 10.1016/S0031-9384(03)00148-3
Ishizaki T, 2010, J CEREBR BLOOD F MET, V30, P1756, DOI 10.1038/jcbfm.2010.39
Kravitz AV, 2012, NAT NEUROSCI, V15, P816, DOI 10.1038/nn.3100
Kreitzer AC, 2007, NATURE, V445, P643, DOI 10.1038/nature05506
Lai T, 2008, NEURON, V57, P232, DOI 10.1016/j.neuron.2007.12.023
Marin O, 2000, J NEUROSCI, V20, P6063
McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
Molnar Z, 2006, NEUROSCI RES, V55, P105, DOI 10.1016/j.neures.2006.02.008
Molyneaux BJ, 2009, J NEUROSCI, V29, P12343, DOI 10.1523/JNEUROSCI.6108-08.2009
Nieman BJ, 2007, HUM BRAIN MAPP, V28, P567, DOI 10.1002/hbm.20408
Nobrega-Pereira S, 2010, J NEUROSCI, V30, P2824, DOI 10.1523/JNEUROSCI.4023-09.2010
Olsen SR, 2012, NATURE, V483, P47, DOI 10.1038/nature10835
Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
Sasaki S, 2008, MOL CELL NEUROSCI, V38, P474, DOI 10.1016/j.mcn.2008.04.002
Seong HJ, 2012, J NEUROSCI, V32, P10516, DOI 10.1523/JNEUROSCI.1367-12.2012
Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
Silverman JL, 2011, BRAIN RES, V1380, P120, DOI 10.1016/j.brainres.2010.09.026
Suter DM, 2011, SCIENCE, V332, P472, DOI 10.1126/science.1198817
Takemoto M, 2011, CEREB CORTEX, V21, P1925, DOI 10.1093/cercor/bhq265
Tang SHE, 2002, GENESIS, V32, P199, DOI 10.1002/gene.10030
Thurley K, 2008, J NEUROPHYSIOL, V99, P2985, DOI 10.1152/jn.01098.2007
Wahlsten D, 2003, BRAIN RES, V971, P47, DOI 10.1016/S0006-8993(03)02354-0
WARD JH, 1963, J AM STAT ASSOC, V58, P236, DOI 10.2307/2282967
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Yang M, 2011, CURR PROTOC NEUROSCI, V8, P8
Yang M, 2009, CURR PROTOC NEUROSCI, V8
Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
Yoo AS, 2011, NATURE, V476, P228, DOI 10.1038/nature10323
NR 61
TC 8
Z9 8
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD MAY
PY 2014
VL 7
IS 4
BP 1077
EP 1092
DI 10.1016/j.celrep.2014.03.036
PG 16
WC Cell Biology
SC Cell Biology
GA AH9WL
UT WOS:000336495700018
PM 24794428
ER
PT J
AU Keri, S
AF Keri, Szabolcs
TI Social influence on associative learning: Double dissociation in
high-functioning autism, early-stage behavioural variant frontotemporal
dementia and Alzheimer's disease
SO CORTEX
LA English
DT Article
DE Autism; Alzheimer's disease; Behavioural variant frontotemporal
dementia; Paired associates learning; Social cognition; Theory of Mind
ID MILD COGNITIVE IMPAIRMENT; LOBAR DEGENERATION; EPISODIC MEMORY;
DIFFERENTIAL-DIAGNOSIS; NETWORK CONNECTIVITY; ASPERGER-SYNDROME; REVISED
VERSION; MIND DEFICITS; ATROPHY; DYSFUNCTION
AB Introduction: Most of our learning activity takes place in a social context. I examined how social interactions influence associative learning in neurodegenerative diseases and atypical neurodevelopmental conditions primarily characterised by social cognitive and memory dysfunctions.
Methods: Participants were individuals with high-functioning autism (HFA, n = 18), earlystage behavioural variant frontotemporal dementia (bvFTD, n = 16) and Alzheimer's disease (AD, n = 20). The leading symptoms in HFA and bvFTD were social and behavioural dysfunctions, whereas AD was characterised by memory deficits. Participants received three versions of a paired associates learning task. In the game with boxes test, objects were hidden in six candy boxes placed in different locations on the computer screen. In the game with faces, each box was labelled by a photo of a person. In the real-life version of the game, participants played with real persons.
Results: Individuals with HFA and bvFTD performed well in the computer games, but failed on the task including real persons. In contrast, in patients with early-stage AD, social interactions boosted paired associates learning up to the level of healthy control volunteers. Worse performance in the real life game was associated with less successful recognition of complex emotions and mental states in the Reading the Mind in the Eyes Test. Spatial span did not affect the results.
Conclusions: When social cognition is impaired, but memory systems are less compromised (HFA and bvFTD), real-life interactions disrupt associative learning; when disease process impairs memory systems but social cognition is relatively intact (early-stage AD), social interactions have a beneficial effect on learning and memory. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Keri, Szabolcs] Univ Szeged, Dept Physiol, Fac Med, H-6720 Szeged, Hungary.
[Keri, Szabolcs] Nyiro Gyula Hosp, Natl Inst Psychiat & Addict, Budapest, Hungary.
[Keri, Szabolcs] Budapest Univ Technol & Econ, Dept Cognit Sci, Budapest, Hungary.
RP Keri, S (reprint author), Univ Szeged, Dept Physiol, Dom Sq 10, H-6720 Szeged, Hungary.
EM keri.szabolcs.gyula@med.u-szeged.hu
FU European Union; European Social Fund; National Brain Research Program
FX I am grateful to Ibolya Halasz, Katalin Kiss, Zoltan Fekete, Oguz
Kelemen and Henrik Vougt for their assistance in the recruitment and
assessment of the patients and neuro-imaging analysis. This research was
realized in the frames of TAMOP 4.2.4. A/2-11-1-2012-0001 "National
Excellence Program - elaborating and operating an inland student and
researcher personal support system". The project was subsidized by the
European Union and co-financed by the European Social Fund and the
National Brain Research Program.
CR Adenzato M, 2010, NEUROPSYCHOLOGIA, V48, P2, DOI 10.1016/j.neuropsychologia.2009.08.001
Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514
Allen TA, 2013, P NATL ACAD SCI USA, V110, P10379, DOI 10.1073/pnas.1301199110
Baglio F, 2012, J ALZHEIMERS DIS, V29, P25, DOI 10.3233/JAD-2011-111256
Barnes J, 2006, ARCH NEUROL-CHICAGO, V63, P1434, DOI 10.1001/archneur.63.10.1434
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
BENTON AL, 1968, NEUROPSYCHOLOGIA, V6, P53, DOI 10.1016/0028-3932(68)90038-9
Bertoux M., 2013, BIOL PSYCHIAT
Blackwell AD, 2004, DEMENT GERIATR COGN, V17, P42, DOI 10.1159/000074081
Boucher J, 2012, PSYCHOL BULL, V138, P458, DOI 10.1037/a0026869
Boutet C, 2012, NEURORADIOLOGY, V54, P1321, DOI 10.1007/s00234-012-1058-0
Brennan PA, 2006, PHILOS T R SOC B, V361, P2061, DOI 10.1098/rstb.2006.1931
Cacioppo JT, 2011, ANN NY ACAD SCI, V1224, P162, DOI 10.1111/j.1749-6632.2010.05858.x
Clague F, 2005, NEUROPSYCHOLOGIA, V43, P1338, DOI 10.1016/j.neuropsychologia.2004.11.023
CUMMINGS JL, 1994, NEUROLOGY, V44, P2308
de Rover M, 2011, NEUROPSYCHOLOGIA, V49, P2060, DOI 10.1016/j.neuropsychologia.2011.03.037
de Souza LC, 2011, J NEUROL NEUROSUR PS, V82, P240, DOI 10.1136/jnnp.2010.207183
de Souza LC, 2013, J ALZHEIMERS DIS, V36, P57, DOI 10.3233/JAD-122293
Davidson PSR, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00531
Emery NJ, 2004, SCIENCE, V306, P1903, DOI 10.1126/science.1098410
Filippi M, 2013, CORTEX, V49, P2389, DOI 10.1016/j.cortex.2012.09.017
Fiske S. T., 2013, SOCIAL COGNITION BRA, V2nd
FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
Frisch S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055251
Frith CD, 2012, ANNU REV PSYCHOL, V63, P287, DOI 10.1146/annurev-psych-120710-100449
Frith U, 2012, Q J EXP PSYCHOL, V65, P2073, DOI 10.1080/17470218.2012.697178
Graham A, 2005, BRAIN, V128, P597, DOI 10.1093/brain/awh348
Gregory C, 2002, BRAIN, V125, P752, DOI 10.1093/brain/awf079
Hamann SB, 2000, NEUROPSYCHOLOGY, V14, P82, DOI 10.1037//0894-4105.14.1.82
Hodges JR, 2013, J ALZHEIMERS DIS, V33, pS211, DOI 10.3233/JAD-2012-129038
Homberger M., 2010, NEUROLOGY, V74, P472
Homberger M, 2012, BRAIN 3, V135, P678
Hornberger M, 2012, BRAIN, V135, P3015, DOI 10.1093/brain/aws239
Irish M, 2013, CORTEX, V49, P2377, DOI 10.1016/j.cortex.2013.03.002
Jacobs HIL, 2013, NEUROSCI BIOBEHAV R, V37, P753, DOI 10.1016/j.neubiorev.2013.03.009
Kazui H, 2000, BRIT J PSYCHIAT, V177, P343, DOI 10.1192/bjp.177.4.343
Keane J, 2002, NEUROPSYCHOLOGIA, V40, P655, DOI 10.1016/S0028-3932(01)00156-7
Kipps CM, 2008, NEUROLOGY, V70, P2046, DOI 10.1212/01.wnl.0000313366.76973.8a
Kipps CM, 2007, DEMENT GERIATR COGN, V23, P334, DOI 10.1159/000100973
Konya A., 1995, REY EMLEKEZETVIZSGAL
Laisney M, 2013, J NEUROPSYCHOL, V7, P107, DOI 10.1111/j.1748-6653.2012.02038.x
Le Bouc R, 2012, BRAIN, V135, P3026, DOI 10.1093/brain/aws237
Lee ACH, 2003, EUR J NEUROSCI, V18, P1660, DOI 10.1046/j.1460-9568.2003.02883.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Mandal PK, 2012, J ALZHEIMERS DIS, V31, pS117, DOI 10.3233/JAD-2012-120901
Mathuranath PS, 2000, NEUROLOGY, V55, P1613
MCKHANN G, 1984, NEUROLOGY, V34, P939
MILNER B, 1971, BRIT MED BULL, V27, P272
Moayeri SE, 2000, NEUROREPORT, V11, P653, DOI 10.1097/00001756-200003200-00001
Moreau N, 2013, AGEING RES REV, V12, P833, DOI 10.1016/j.arr.2013.06.005
Mori E, 1999, AM J PSYCHIAT, V156, P216
Neary D, 1998, NEUROLOGY, V51, P1546
NELSON HE, 1976, CORTEX, V12, P313
Nemeth D., 2013, APPL NEUROPSYCHOLOGY
O'Connell H, 2004, INT J GERIATR PSYCH, V19, P1207, DOI 10.1002/gps.1180
OWEN AM, 1990, NEUROPSYCHOLOGIA, V28, P1021, DOI 10.1016/0028-3932(90)90137-D
Pardini M, 2013, J NEUROL NEUROSUR PS, V84, P818, DOI 10.1136/jnnp-2012-303684
Pocnet C, 2013, INT J GERIATR PSYCH, V28, P276, DOI 10.1002/gps.3822
Poletti M, 2012, NEUROSCI BIOBEHAV R, V36, P2147, DOI 10.1016/j.neubiorev.2012.07.004
Racsmany M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029992
Rascovsky K, 2011, BRAIN, V134, P2456, DOI 10.1093/brain/awr179
Rey A., 1941, ARCH PSYCHOL, V28, P215
SAHAKIAN BJ, 1988, BRAIN, V111, P695, DOI 10.1093/brain/111.3.695
SCHELTENS P, 1992, J NEUROL NEUROSUR PS, V55, P967, DOI 10.1136/jnnp.55.10.967
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Sestieri C, 2011, J NEUROSCI, V31, P4407, DOI 10.1523/JNEUROSCI.3335-10.2011
Shi J, 2005, ACTA NEUROPATHOL, V110, P501, DOI 10.1007/s00401-005-1079-4
Stacho L., 2003, PSYCHIAT HUNGARICA, V18, P226
Stopford CL, 2012, CORTEX, V48, P429, DOI 10.1016/j.cortex.2010.12.002
Sturm VE, 2013, P NATL ACAD SCI USA, V110, P9944, DOI 10.1073/pnas.1301119110
Swainson R, 2001, DEMENT GERIATR COGN, V12, P265, DOI 10.1159/000051269
Torralva T, 2009, BRAIN, V132, P1299, DOI 10.1093/brain/awp041
Tulving E., 1972, ORG MEMORY, P381
Weber Max, 1978, EC SOC
Wechsler D., 1987, WECHSLER MEMORY SCAL
Wechsler D, 1999, WECHSLER ABBREVIATED
Williams DL, 2006, CHILD NEUROPSYCHOL, V12, P279, DOI 10.1080/09297040600681190
Williams DL, 2005, ARCH CLIN NEUROPSYCH, V20, P1, DOI 10.1016/j.acn.2002.08.001
Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21
Zhou J, 2010, BRAIN, V133, P1352, DOI 10.1093/brain/awq075
NR 81
TC 1
Z9 1
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0010-9452
EI 1973-8102
J9 CORTEX
JI Cortex
PD MAY
PY 2014
VL 54
BP 200
EP 209
DI 10.1016/j.cortex.2014.02.018
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AH9LW
UT WOS:000336464900017
PM 24709075
ER
PT J
AU Utine, GE
Haliloglu, G
Volkan-Salanci, B
Cetinkaya, A
Kiper, PO
Alanay, Y
Aktas, D
Anlar, B
Topcu, M
Boduroglu, K
Alikasifoglu, M
AF Utine, G. Eda
Haliloglu, Goknur
Volkan-Salanci, Bilge
Cetinkaya, Arda
Kiper, Pelin O.
Alanay, Yasemin
Aktas, Dilek
Anlar, Banu
Topcu, Meral
Boduroglu, Koray
Alikasifoglu, Mehmet
TI Etiological yield of SNP microarrays in idiopathic intellectual
disability
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Article
DE SNP microarray; Intellectual disability; NRXN1; FOXP2; UBE2A;
Uniparental disomy; Subtelomeric rearrangements
ID GLOBAL DEVELOPMENTAL DELAY; MENTAL-RETARDATION SYNDROME; AUTISM SPECTRUM
DISORDER; CLINICAL DIAGNOSTIC-TEST; CHROMOSOMAL MICROARRAY; DYSMORPHIC
FEATURES; CA2+ CHANNELS; SPEECH DELAY; ARRAY CGH; DELETION
AB Intellectual disability (ID) has a prevalence of 3% and is classified according to its severity. An underlying etiology cannot be determined in 75-80% in mild ID, and in 20-50% of severe ID. After it has been shown that copy number variations involving short DNA segments may cause ID, genome-wide SNP microarrays are being used as a tool for detecting submicroscopic copy number changes and uniparental disomy. This study was performed to investigate the presence of copy number changes in patients with ID of unidentified etiology. Affymetrix (R) 6.0 SNP microarray platform was used for analysis of 100 patients and their healthy parents, and data were evaluated using various databases and literature. Etiological diagnoses were made in 12 patients (12%). Homozygous deletion in NRXN1 gene and duplication in IL1RAPL1 gene were detected for the first time. Two separate patients had deletions in FOXP2 and UBE2A genes, respectively, for which only few patients have recently been reported. Interstitial and subtelomeric copy number changes were described in 6 patients, in whom routine cytogenetic tools revealed normal results. In one patient uniparental disomy type of Angelman syndrome was diagnosed. SNP microarrays constitute a screening test able to detect very small genomic changes, with a high etiological yield even in patients already evaluated using traditional cytogenetic tools, offer analysis for uniparental disomy and homozygosity, and thereby are helpful in finding novel disease-causing genes: for these reasons they should be considered as a first-tier genetic screening test in the evaluation of patients with ID and autism. (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
C1 [Utine, G. Eda; Haliloglu, Goknur; Volkan-Salanci, Bilge; Kiper, Pelin O.; Alanay, Yasemin; Anlar, Banu; Topcu, Meral; Boduroglu, Koray] Hacettepe Univ, Dept Pediat, Ankara, Turkey.
[Utine, G. Eda; Volkan-Salanci, Bilge; Cetinkaya, Arda; Kiper, Pelin O.; Alanay, Yasemin; Aktas, Dilek; Boduroglu, Koray; Alikasifoglu, Mehmet] Hacettepe Univ, Dept Pediat Genet, Ankara, Turkey.
[Haliloglu, Goknur; Anlar, Banu; Topcu, Meral] Hacettepe Univ, Dept Pediat Neurol, Ankara, Turkey.
[Cetinkaya, Arda; Aktas, Dilek; Alikasifoglu, Mehmet] Hacettepe Univ, Dept Med Genet, Ankara, Turkey.
RP Utine, GE (reprint author), Hacettepe Univ, Dept Pediat, Dept Pediat Genet, Ankara, Turkey.
EM geutine@hacettepe.edu.tr
CR Battaglia A, 2013, EUR J PAEDIATR NEURO, V17, P589, DOI 10.1016/j.ejpn.2013.04.010
Brisset S, 2002, AM J MED GENET, V113, P339, DOI 10.1002/ajmg.10740
Bruno DL, 2011, HUM MUTAT, V32, P1500, DOI 10.1002/humu.21581
Bruno DL, 2011, J MED GENET, V48, P831, DOI 10.1136/jmedgenet-2011-100372
Budny B, 2010, CLIN GENET, V77, P541, DOI 10.1111/j.1399-0004.2010.01429.x
Cody JD, 2007, AM J MED GENET A, V143A, P1181, DOI 10.1002/ajmg.a.31729
de Leeuw N, 2010, AM J MED GENET A, V152A, P3084, DOI 10.1002/ajmg.a.33743
Feenstra I, 2007, AM J MED GENET A, V143A, P1858, DOI 10.1002/ajmg.a.31850
FU YH, 1991, CELL, V67, P1047, DOI 10.1016/0092-8674(91)90283-5
Gregor A, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-106
Harrison V, 2011, AM J MED GENET A, V155A, P2826, DOI 10.1002/ajmg.a.34255
Hellani A, 2010, AM J MED GENET A, V152A, P1555, DOI 10.1002/ajmg.a.33400
Kaminsky EB, 2011, GENET MED, V13, P777, DOI 10.1097/GIM.0b013e31822c79f9
Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
Lai CSL, 2000, AM J HUM GENET, V67, P357, DOI 10.1086/303011
Lennon PA, 2007, AM J MED GENET A, V143A, P791, DOI 10.1002/ajmg.a.31632
MAHER ER, 1991, J MED GENET, V28, P801, DOI 10.1136/jmg.28.11.801
Manning M, 2010, GENET MED, V12, P742, DOI 10.1097/GIM.0b013e3181f8baad
Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
Missler M, 2003, NATURE, V423, P939, DOI 10.1038/nature01755
Nascimento RMP, 2006, AM J HUM GENET, V79, P549, DOI 10.1086/507047
Nawara M, 2008, AM J MED GENET A, V146A, P3167, DOI 10.1002/ajmg.a.32613
Pescucci C, 2007, EUR J MED GENET, V50, P21, DOI 10.1016/j.ejmg.2006.09.001
POISSONNIER M, 1992, ANN GENET-PARIS, V35, P146
Puffenberger EG, 2012, HUM MUTAT, V33, P1639, DOI 10.1002/humu.22237
Reissner C, 2008, P NATL ACAD SCI USA, V105, P15124, DOI 10.1073/pnas.0801639105
ROUSSEAU F, 1991, NEW ENGL J MED, V325, P1673, DOI 10.1056/NEJM199112123252401
Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
Schinzel A., 2001, CATALOGUE UNBALANCED
Shapiro BK, 2007, NELSON TXB PEDIAT, P191
Shevell M, 2003, NEUROLOGY, V60, P367
Shevell MI, 2008, AM J MED GENET B, V147B, P1101, DOI 10.1002/ajmg.b.30730
Siggberg L, 2010, AM J MED GENET A, V152A, P1398, DOI 10.1002/ajmg.a.33402
Stromme P, 2000, DEV MED CHILD NEUROL, V42, P76, DOI 10.1017/S0012162200000165
TAKAYAMA C, 1995, NEUROSCI LETT, V188, P89, DOI 10.1016/0304-3940(95)11403-J
Utine GE, 2013, J CHILD NEUROL, V28, P926, DOI 10.1177/0883073813484967
Vermeesch JR, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.8.e93
Zahir FR, 2008, J MED GENET, V45, P239, DOI 10.1136/jmg.2007.054437
Zhang WQ, 2005, J NEUROSCI, V25, P4330, DOI 10.1523/JNEUROSCI.0497-05.2005
Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 40
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
EI 1532-2130
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD MAY
PY 2014
VL 18
IS 3
BP 327
EP 337
DI 10.1016/j.ejpn.2014.01.004
PG 11
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA AI2NQ
UT WOS:000336695500012
PM 24508361
ER
PT J
AU Goddard, E
Carral-Fernandez, L
Denneny, E
Campbell, IC
Treasure, J
AF Goddard, Elizabeth
Carral-Fernandez, Laura
Denneny, Emma
Campbell, Iain C.
Treasure, Janet
TI Cognitive flexibility, central coherence and social emotional processing
in males with an eating disorder
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Anorexia nervosa; Eating disorders; Gender; Neuropsychology; Cognitive
flexibility
ID AUTISM SPECTRUM DISORDERS; ANOREXIA-NERVOSA PATIENTS; BULIMIA-NERVOSA;
ASPERGER-SYNDROME; GENDER-DIFFERENCES; EMBEDDED FIGURES; WEAK COHERENCE;
RECOGNITION; MIND; PERFECTIONISM
AB Objectives. Females are more likely to develop an eating disorder (ED) than males. Studies of affected men may therefore inform models of risk and resilience to EDs. The aim of this study was to examine putative neurocognitive intermediate phenotypes of EDs in affected males. Methods. Cognitive flexibility, central coherence (global/detail processing), complex emotion recognition and social-threat sensitivity were investigated in men with EDs and healthy men. Measures of distress, perfectionism, and obsessive compulsivity were collected. Results. Men with EDs were more cognitively inflexible across tasks and had more difficulty integrating global information than healthy men. Unexpectedly, there were no group differences on a visuospatial task of detail processing or on social-emotional processing tasks. Men with EDs had higher scores on measures of distress, perfectionism and obsessive compulsivity than healthy men. Conclusions. Men with EDs share some of the intermediate cognitive phenotype present in women with EDs. Like their female counterparts, males with EDs show an inflexible, fragmented cognitive style. However, relative to healthy men, men with EDs do not have superior detail processing abilities, poor emotion recognition or increased sensitivity to social-threat. It is possible that gender differences in social-threat processing contribute to the female preponderance of EDs.
C1 [Goddard, Elizabeth; Campbell, Iain C.; Treasure, Janet] Kings Coll London, Dept Psychol Med, Sect Eating Disorders, Inst Psychiat, London WC2R 2LS, England.
[Carral-Fernandez, Laura] Univ Hosp Marques de Valdecilla, Eating Disorders Unit, Santander, Spain.
[Denneny, Emma] Guys Kings & St Thomas Sch Med, London, England.
RP Goddard, E (reprint author), Sect Eating Disorders, P059,103 Denmark Hill, London SE5 8AF, England.
EM Elizabeth.Goddard@kcl.ac.uk
FU National Institute for Health Research (NIHR) [RP-PG-0606-1043]; NIHR
[PB-PG-0609-19025]; Marques de Valdecilla Public Foundation-Research
Institute (FMV-IFIMAV, Santander, Spain); Institute of Health Carlos III
(Spain)
FX This article discusses independent research funded by the National
Institute for Health Research (NIHR) under its Programme Grants for
Applied Research scheme (RP-PG-0606-1043). EG was supported by research
funded by NIHR under its Research for Patient Benefit programme
(PB-PG-0609-19025). The views expressed are those of the author(s) and
not necessarily those of the NHS, the NIHR or the Department of Health.
Laura Carral-Fernandez was supported by a jointly funded research
training fellowship from the Marques de Valdecilla Public
Foundation-Research Institute (FMV-IFIMAV, Santander, Spain) and the
Institute of Health Carlos III (Spain).
CR Anderson Charles B, 2004, Eat Behav, V5, P1, DOI 10.1016/j.eatbeh.2003.07.001
Ashwin C, 2006, PSYCHOL MED, V36, P835, DOI 10.1017/S0033291706007203
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
Bohn K., 2008, COGNITIVE BEHAV THER, P315
Booth R., 2006, THESIS KINGS COLL LO
Bramon-Bosch E, 2000, EUR EAT DISORD REV, V8, P321, DOI 10.1002/1099-0968(200008)8:4<321::AID-ERV355>3.0.CO;2-G
Burgess PW, 1997, HAYLING BRIXTON TEST
Button E, 2008, INT J EAT DISORDER, V41, P758, DOI 10.1002/eat.20553
Cardi V, 2012, WORLD J BIOL PSYCHIA
Carlat DJ, 1997, AM J PSYCHIAT, V154, P1127
Castro L, 2010, AUST NZ J PSYCHIAT, V44, P1118, DOI 10.3109/00048674.2010.524625
COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
Connan F, 2003, PHYSIOL BEHAV, V79, P13, DOI 10.1016/S0031-9384(03)00101-X
Crisp A, 2006, EUR EAT DISORD REV, V14, P163, DOI 10.1002/erv.703
Darcy AM, 2011, INT J EAT DISORDER, V45, P110
Davies H, 2009, EAT WEIGHT DISORD-ST, V14, pE84
Fairburn C. G., 2008, COGNITIVE BEHAV THER
Fassino S, 2001, J NERV MENT DIS, V189, P788, DOI 10.1097/00005053-200111000-00009
Faul F, 1992, G POWER
Fernandez-Aranda F, 2004, EUR EAT DISORD REV, V12, P367, DOI 10.1002/erv.603
Foa EB, 2002, PSYCHOL ASSESSMENT, V14, P485, DOI 10.1037//1040-3590.14.4.485
FROST RO, 1990, COGNITIVE THER RES, V14, P449, DOI 10.1007/BF01172967
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
Halmi KA, 2000, AM J PSYCHIAT, V157, P1799, DOI 10.1176/appi.ajp.157.11.1799
Halmi KA, 2005, INT J EAT DISORDER, V38, P371, DOI 10.1002/eat.20190
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Happe FGE, 2008, Q J EXP PSYCHOL, V61, P50, DOI 10.1080/17470210701508731
Harrison A, 2009, CLIN PSYCHOL PSYCHOT, V16, P348, DOI 10.1002/cpp.628
Harrison A, 2010, PSYCHOL MED, V40, P1887, DOI 10.1017/S0033291710000036
Harrison A, 2011, WORLD J BIOL PSYCHIA, V12, P462, DOI 10.3109/15622975.2010.551666
Harrison A, 2012, BRIT J CLIN PSYCHOL, V51, P261, DOI 10.1111/j.2044-8260.2011.02026.x
Heaton RK, 1993, WISCONSIN CARD SORTI
Hebebrand J, 1996, INT J EAT DISORDER, V19, P359, DOI 10.1002/(SICI)1098-108X(199605)19:4<359::AID-EAT4>3.0.CO;2-K
HOCHBERG Y, 1988, BIOMETRIKA, V75, P800, DOI 10.1093/biomet/75.4.800
Holliday J, 2005, AM J PSYCHIAT, V162, P2269, DOI 10.1176/appi.ajp.162.12.2269
Jacobi C, 2004, PSYCHOL BULL, V130, P19, DOI 10.1037/0033-2909.130.1.19
Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
Kaye W, 2008, PHYSIOL BEHAV, V94, P121, DOI 10.1016/j.physbeh.2007.11.037
Kenyon M, 2012, INT J EAT DISORDER, V45, P377, DOI 10.1002/eat.20967
Kucharska-Pietura K, 2004, INT J EAT DISORDER, V35, P42, DOI 10.1002/eat.10219
Lopez C, 2008, INT J EAT DISORDER, V41, P143, DOI 10.1002/eat.20478
Lopez C, 2009, J CLIN EXP NEUROPSYC, V31, P117, DOI 10.1080/13803390802036092
Lopez CA, 2008, INT J EAT DISORDER, V41, P340, DOI 10.1002/eat.20511
LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
Mogg K, 2007, BIOL PSYCHOL, V76, P163, DOI 10.1016/j.biopsycho.2007.07.005
Nelson H. E., 1982, NATL ADULT READING T
Nunez-Navarro A, 2011, EUR EAT DISORD REV, V20, P23
Oldershaw A, 2011, NEUROSCI BIOBEHAV R, V35, P970, DOI 10.1016/j.neubiorev.2010.11.001
Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
Osterrieth P, 1944, ARCH PSYCHOL, V30, P206
Parker GB, 2004, J NERV MENT DIS, V192, P210, DOI 10.1097/01.nmd.0000116464.60500.63
Pearson R, 2005, HORM BEHAV, V47, P267, DOI 10.1016/j.yhbeh.2004.11.003
Pigott TA, 1999, J CLIN PSYCHIAT, V60, P4
Reitan RM, 1955, J CONSULT PSYCHOL, V19, P393, DOI 10.1037/h0044509
Roberts ME, 2010, J PSYCHIATR RES, V44, P964, DOI 10.1016/j.jpsychires.2010.03.001
Roberts ME, 2012, WORLD J BIOL PSYCHIA
Roberts ME, 2009, THESIS KINGS COLL LO
Roberts ME, 2007, PSYCHOL MED, V37, P1075, DOI 10.1017/S0033291707009877
Rosenthal R, 1991, METAANALYTIC PROCEDU
Russell TA, 2009, PSYCHIAT RES, V168, P181, DOI 10.1016/j.psychres.2008.10.028
Schmidt U, 2006, BRIT J CLIN PSYCHOL, V45, P343, DOI 10.1348/014466505X53902
Schuepbach D, 2009, BRAIN COGNITION, V71, P313, DOI 10.1016/j.bandc.2009.07.006
SNODGRASS JG, 1987, BEHAV RES METH INSTR, V19, P270, DOI 10.3758/BF03203798
Southgate L, 2008, EUR EAT DISORD REV, V16, P451, DOI 10.1002/erv.870
Steinglass JE, 2011, INT J EAT DISORDER, V44, P134, DOI 10.1002/eat.20784
Strober M, 2006, INT J EAT DISORDER, V39, P570, DOI 10.1002/eat.20293
Tchanturia K, 2004, J INT NEUROPSYCH SOC, V10, P513, DOI 10.1017/S1355617704104086
Tchanturia K, 2011, EUR EAT DISORD REV, V20, P169
Tchanturia K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020462
Tchanturia K, 2004, J PSYCHIAT RES, V38, P545, DOI 10.1016/j.jphyschires.2004.03.001
Tchanturia K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028331
Tenconi E, 2010, WORLD J BIOL PSYCHIA, V11, P813, DOI 10.3109/15622975.2010.483250
Welch E, 2011, BEHAV RES THER, V49, P85, DOI 10.1016/j.brat.2010.10.010
Witkin H. A., 2002, GROUP EMBEDDED FIGUR
WITKIN HA, 1950, J PERS, V19, P1, DOI 10.1111/j.1467-6494.1950.tb01084.x
Woodside DB, 2004, J PSYCHOSOM RES, V57, P273, DOI 10.1016/j.jpsychores.2004.02.011
NR 78
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD MAY
PY 2014
VL 15
IS 4
BP 317
EP 326
DI 10.3109/15622975.2012.750014
PG 10
WC Psychiatry
SC Psychiatry
GA AI1AH
UT WOS:000336581500007
PM 23336111
ER
PT J
AU Sarkar, S
Craig, MC
Dell'Acqua, F
O'Connor, TG
Catani, M
Deeley, Q
Glover, V
Murphy, DGM
AF Sarkar, Sagari
Craig, Michael C.
Dell'Acqua, Flavio
O'Connor, Thomas G.
Catani, Marco
Deeley, Quinton
Glover, Vivette
Murphy, Declan G. M.
TI Prenatal stress and limbic-prefrontal white matter microstructure in
children aged 6-9 years: a preliminary diffusion tensor imaging study
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE DT-MRI; prenatal stress; neuroimaging; uncinate fasciculus; white matter
ID MATERNAL ANTENATAL ANXIETY; BEHAVIOURAL/EMOTIONAL PROBLEMS; ADHD
SYMPTOMS; HUMAN BRAIN; PREGNANCY; CHILDHOOD; EXPOSURE; AUTISM;
TEMPERAMENT; FEARFULNESS
AB Objectives. Maternal prenatal stress is associated with elevated risk of adverse behavioural outcomes in offspring. This association may involve developmental disruption to limbic-prefrontal white matter circuitry, of which the uncinate fasciculus is the major tract. One potential candidate for modulating brain development is maternal prenatal stress. We provide the first prospective study of prenatal stress and white matter microstructure in children. Methods. A total of 22 healthy children (mean age 7 years) of mothers recruited in pregnancy underwent diffusion tensor magnetic resonance imaging. We examined correlations between prenatal stressful life events and white matter microstructural organisation indices (fractional anisotropy (FA) and perpendicular diffusivity (D-perp)) of the uncinate fasciculus and a "control" tract. Results. Maternal prenatal stressful life events were correlated positively with right uncinate fasciculus FA, and negatively with right uncinate fasciculus D-perp in their child, with a similar trend with left uncinate fasciculus D-perp. Prenatal stress was not associated with control tract properties; sociodemographic/obstetric variables were not associated with FA/D-perp of either tract. Conclusions. Variation in maternal prenatal stress may be associated with differences in the development of white matter within brain networks underlying child social behaviour.
C1 [Sarkar, Sagari; Craig, Michael C.; Dell'Acqua, Flavio; Catani, Marco; Deeley, Quinton; Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London WC2R 2LS, England.
[Craig, Michael C.; Dell'Acqua, Flavio; Catani, Marco] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, Natbrainlab, London WC2R 2LS, England.
[Craig, Michael C.; Dell'Acqua, Flavio; Catani, Marco; Deeley, Quinton; Murphy, Declan G. M.] Kings Coll London, NIHR Biomed Res Ctr Mental Hlth, South London & Maudsley NHS Fdn Trust, London WC2R 2LS, England.
[Craig, Michael C.; Dell'Acqua, Flavio; Catani, Marco; Deeley, Quinton; Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
[O'Connor, Thomas G.] Univ Rochester, Med Ctr, Dept Psychiat, Rochester, NY 14642 USA.
[Glover, Vivette] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London, England.
[Sarkar, Sagari] Kings Coll London, Inst Psychiat, Dept Neuroimaging, London WC2R 2LS, England.
[Craig, Michael C.] South London & Maudsley NHS Fdn Trust, Bethlem Royal Hosp, Natl Autism Unit, London, England.
RP Craig, MC (reprint author), Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London WC2R 2LS, England.
EM michael.c.craig@kcl.ac.uk
FU March of Dimes foundation; Baily Thomas Charitable Fund; Academy of
Medical Sciences; NIHR Biomedical Research Centre for Mental Health at
King's College London; Institute of Psychiatry; South London & Maudsley
NHS Foundation Trust
FX This work was funded by the March of Dimes foundation, Baily Thomas
Charitable Fund, The Academy of Medical Sciences, the NIHR Biomedical
Research Centre for Mental Health at King's College London, Institute of
Psychiatry and South London & Maudsley NHS Foundation Trust, and a
generous donation from a private individual. We would also like to thank
all the children and their parents for taking part. We would like to
acknowledge Fiona Rose-Clarke for her assistance with recruitment and
data collection.
CR Allin M, 2010, NEURODEVELOPMENTAL O, P97, DOI 10.1017/CBO9780511712166.009
Ashtari M, 2011, DEV MED CHILD NEUROL, V54, P6, DOI [10.1038/ni.3099, DOI 10.1038/NI.3099]
Barker ED, 2009, AM J PSYCHIAT, V166, P900, DOI 10.1176/appi.ajp.2009.08121770
BARNETT BEW, 1983, J PSYCHOSOM RES, V27, P313, DOI 10.1016/0022-3999(83)90054-5
Basser PJ, 2000, MAGNET RESON MED, V44, P625, DOI 10.1002/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O
Beaulieu C, 2009, DIFFUSION MRI: FROM QUANTITATIVE MEASUREMENT TO IN VIVO NEUROANATOMY, P105, DOI 10.1016/B978-0-12-374709-9.00006-7
Bergman K, 2007, J AM ACAD CHILD PSY, V46, P1454, DOI 10.1097/chi.0b013e31814a62f6
Bergman K, 2008, J CHILD PSYCHOL PSYC, V49, P1089, DOI 10.1111/j.1469-7610.2008.01987.x
Beversdorf DQ, 2005, J AUTISM DEV DISORD, V35, P471, DOI 10.1007/s10803-005-5037-8
Buss C, 2010, PSYCHONEUROENDOCRINO, V35, P141, DOI 10.1016/j.psyneuen.2009.07.010
Buss C, 2012, P NATL ACAD SCI USA, V109, pE1312, DOI 10.1073/pnas.1201295109
Catani M, 2008, CORTEX, V44, P1105, DOI 10.1016/j.cortex.2008.05.004
Catani M, 2002, NEUROIMAGE, V17, P77, DOI 10.1006/nimg.2002.1136
Chang LC, 2005, MAGNET RESON MED, V53, P1088, DOI 10.1002/mrm.20426
COX JL, 1987, BRIT J PSYCHIAT, V150, P782, DOI 10.1192/bjp.150.6.782
Craig MC, 2009, MOL PSYCHIATR, V14, P946, DOI 10.1038/mp.2009.40
Deoni SCL, 2011, J NEUROSCI, V31, P784, DOI 10.1523/JNEUROSCI.2106-10.2011
Gutteling BM, 2005, EUR CHILD ADOLES PSY, V14, P41, DOI 10.1007/s00787-005-0435-1
Hay DF, 2010, CHILD DEV, V81, P149, DOI 10.1111/j.1467-8624.2009.01386.x
Huizink AC, 2002, J AM ACAD CHILD PSY, V41, P1078, DOI 10.1097/01.CHI.0000020276.43550.4B
Huizink AC, 2007, ACTA PSYCHIAT SCAND, V116, P438, DOI 10.1111/j.1600-0447.2007.01050.x
Jones DK, 2002, HUM BRAIN MAPP, V15, P216, DOI 10.1002/hbm.10018
Kinney DK, 2008, J AUTISM DEV DISORD, V38, P481, DOI 10.1007/s10803-007-0414-0
Kraszpulski M, 2006, STRESS, V9, P85, DOI 10.1080/10253890600798109
Lagae L, 2007, NEUROPSYCHOPHARMACOL, V33, P536
Lebel C, 2008, NEUROIMAGE, V40, P1044, DOI 10.1016/j.neuroimage.2007.12.053
Leemans A., 2009, P INT SOC MAG RESON, V17, P3537
Marsh R, 2008, J AM ACAD CHILD PSY, V47, P1233, DOI 10.1097/CHI.0b013e318185e703
O'Connor TG, 2003, J CHILD PSYCHOL PSYC, V44, P1025, DOI 10.1111/1469-7610.00187
O'Connor TG, 2002, BRIT J PSYCHIAT, V180, P502, DOI 10.1192/bjp.180.6.502
Rice F, 2010, PSYCHOL MED, V40, P1
Rodriguez A, 2005, J CHILD PSYCHOL PSYC, V46, P246, DOI 10.1111/j.1469-7610.2004.00359.x
Salm AK, 2004, DEV BRAIN RES, V148, P159, DOI 10.1016/j.devbrainres.2003.11.005
Sarkar P, 2006, PRENATAL DIAG, V26, P505, DOI 10.1002/pd.1444
Sarkar S., 2012, PSYCHOL MED, P1, DOI DOI 10.1017/S003329171200116X
Sorensen AG, 2007, P INT SOC MAG RESON, V15, P3720, DOI DOI 10.1038/SJ.IJ0.0803354
Tamura M, 2011, J NEUROSCI, V31, P11505, DOI 10.1523/JNEUROSCI.3447-10.2011
UNO H, 1994, HORM BEHAV, V28, P336, DOI 10.1006/hbeh.1994.1030
Van den Bergh BRH, 2004, CHILD DEV, V75, P1085, DOI 10.1111/j.1467-8624.2004.00727.x
WIGGINS RC, 1986, METAB BRAIN DIS, V1, P197, DOI 10.1007/BF01001781
Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
NR 41
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD MAY
PY 2014
VL 15
IS 4
BP 346
EP 352
DI 10.3109/15622975.2014.903336
PG 7
WC Psychiatry
SC Psychiatry
GA AI1AH
UT WOS:000336581500010
PM 24815522
ER
PT J
AU Mendez, MF
Fong, SS
Shapira, JS
Jimenez, EE
Kaiser, NC
Kremen, SA
Tsai, PH
AF Mendez, Mario F.
Fong, Sylvia S.
Shapira, Jill S.
Jimenez, Elvira E.
Kaiser, Natalie C.
Kremen, Sarah A.
Tsai, Po-Heng
TI Observation of Social Behavior in Frontotemporal Dementia
SO AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
LA English
DT Article
DE dementia; frontotemporal lobar degeneration; Alzheimer's disease; social
behavior; autism
ID LOBAR DEGENERATION; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; MIND
DEFICITS; RATING-SCALE; VARIANT; COGNITION; CONSENSUS
AB Background: The most characteristic manifestations of behavioral variant frontotemporal dementia (bvFTD) are abnormalities in social behavior. However, distinguishing bvFTD based on social behavior can be difficult in structured clinical settings.
Methods: Using a Social Observation Inventory, 10 patients with bvFTD and 10 patients with Alzheimer's disease (AD) were compared to their caregiver interlocutors on 1-hour mealtime, in-home videotaped segments.
Results: Compared to caregivers and patients with AD, patients with bvFTD were significantly disturbed in social behavior. In contrast, patients with AD were indistinguishable from their caregivers. The lack of you comments and decreased tact and manners distinguished 92.6% of the patients with bvFTD from patients with AD and caregivers. The Social Observation Inventory scores correlated with scores on frontal-executive tests and socioemotional scales.
Conclusions: The systematic observation of social behavior during routine activities may be one of the best ways to distinguish patients with bvFTD from normal individuals and from patients with other dementias.
C1 [Mendez, Mario F.; Fong, Sylvia S.; Shapira, Jill S.; Jimenez, Elvira E.; Kaiser, Natalie C.; Kremen, Sarah A.; Tsai, Po-Heng] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.
[Mendez, Mario F.; Fong, Sylvia S.; Shapira, Jill S.; Jimenez, Elvira E.; Kaiser, Natalie C.; Tsai, Po-Heng] VA Greater Los Angeles Healthcare Ctr, Los Angeles, CA 90073 USA.
RP Mendez, MF (reprint author), VA Greater Los Angeles Healthcare Ctr, Neurobehav Unit 691 116AF, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA.
EM mmendez@UCLA.edu
FU NIH [R01AG034499-03]
FX The authors disclosed receipt of the following financial support for the
research, authorship and/or publication of this article: This work was
supported by NIH grant #R01AG034499-03.
CR ABRAMS R, 1978, AM J PSYCHIAT, V135, P226
Adenzato M, 2010, NEUROPSYCHOLOGIA, V48, P2, DOI 10.1016/j.neuropsychologia.2009.08.001
Cairns NJ, 2007, ACTA NEUROPATHOL, V114, P5, DOI 10.1007/s00401-007-0237-2
Cardarelli R, 2010, AM FAM PHYSICIAN, V82, P1372
Cerami C, 2013, NEUROL SCI, V34, P1267, DOI 10.1007/s10072-013-1317-9
Delis DC, 2001, DELIS KAPLAN EXECUTI
Eslinger PJ, 2011, J NEUROPSYCH CLIN N, V23, P74, DOI 10.1176/appi.neuropsych.23.1.74
Eslinger PJ, 2007, J NEUROL NEUROSUR PS, V78, P457, DOI 10.1136/jnnp.2006.098228
FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
Ibanez A, 2012, NEUROLOGY, V78, P1354, DOI 10.1212/WNL.0b013e3182518375
Knopman DS, 2011, ALZHEIMERS DEMENT, V7, P293, DOI 10.1016/j.jalz.2010.12.006
LaMarre AK, 2013, NEUROLOGY, V80, P1973, DOI 10.1212/WNL.0b013e318293e368
Le Bouc R, 2012, BRAIN, V135, P3026, DOI 10.1093/brain/aws237
Lezak MD, 2012, NEUROPSYCHOLOGICAL A, V5th
McKhann GM, 2011, ALZHEIMERS DEMENT, V7, P263, DOI 10.1016/j.jalz.2011.03.005
Mendez Mario F, 2004, Cogn Behav Neurol, V17, P133, DOI 10.1097/01.wnn.0000136593.21532.16
Mendez MF, 2009, CNS SPECTRUMS, V14, P608
Mendez MF, 2003, NEUROCASE, V9, P44, DOI 10.1076/neur.9.1.44.14375
Mendez MF, 2005, COGN BEHAV NEUROL, V18, P193, DOI 10.1097/01.wnn.0000191292.17964.bb
Mendez MF, 2008, J NEUROPSYCH CLIN N, V20, P130, DOI 10.1176/appi.neuropsych.20.2.130
MORRIS JC, 1993, NEUROLOGY, V43, P2412
Mychack P, 2001, NEUROLOGY, V56, pS11
Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
Neary D, 1998, NEUROLOGY, V51, P1546
Snowden J, 2007, ACTA NEUROPATHOL, V114, P31, DOI 10.1007/s00401-007-0236-3
Pardini M, 2013, J NEUROL NEUROSUR PS, V84, P818, DOI 10.1136/jnnp-2012-303684
Passant U, 2005, ALZ DIS ASSOC DIS, V19, pS15, DOI 10.1097/01.wad.0000183084.22562.5a
Rankin KP, 2003, NEUROLOGY, V60, P266
Rascovsky K, 2011, BRAIN, V134, P2456, DOI 10.1093/brain/awr179
Ratnavalli E, 2002, NEUROLOGY, V58, P1615
Rosen HJ, 2002, BRAIN, V125, P2286, DOI 10.1093/brain/awf225
Seeley WW, 2007, ALZ DIS ASSOC DIS, V21, pS50
Shany-Ur T, 2011, CURR OPIN NEUROL, V24, P550, DOI 10.1097/WCO.0b013e32834cd42a
Snowden JS, 2001, J NEUROL NEUROSUR PS, V70, P323, DOI 10.1136/jnnp.70.3.323
Sollberger M, 2009, NEUROPSYCHOLOGIA, V47, P2812, DOI 10.1016/j.neuropsychologia.2009.06.006
Yesavage JA, 1982, J PSYCHIATR RES, V17, P37
Zahn R, 2009, BRAIN, V132, P604, DOI 10.1093/brain/awn343
NR 37
TC 3
Z9 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1533-3175
EI 1938-2731
J9 AM J ALZHEIMERS DIS
JI Am. J. Alzheimers Dis. Other Dement.
PD MAY
PY 2014
VL 29
IS 3
BP 215
EP 221
DI 10.1177/1533317513517035
PG 7
WC Geriatrics & Gerontology; Clinical Neurology
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA AI0HL
UT WOS:000336527000005
PM 24370617
ER
PT J
AU Adamson, LB
Bakeman, R
Deckner, DF
Nelson, PB
AF Adamson, Lauren B.
Bakeman, Roger
Deckner, Deborah F.
Nelson, P. Brooke
TI From Interactions to Conversations: The Development of Joint Engagement
During Early Childhood
SO CHILD DEVELOPMENT
LA English
DT Article
ID LANGUAGE INTERVENTION; YOUNG-CHILDREN; DOWN-SYNDROME; EMERGENCE;
ATTENTION; AUTISM; TODDLERS; MIND; COMMUNICATION; MOTHERS
AB This research traces the development of symbol-infused joint engagement during mother-child interactions into the preschool years. Forty-nine children, who had been previously observed as toddlers (L. B. Adamson, R. Bakeman, & D. F. Deckner, 2004), were systematically observed during interactions with their mothers at ages 31/2, 41/2, and 51/2 during activities related to the past and future, internal states, and graphic systems. Although the amount of symbol-infused joint engagement reached a ceiling by 31/2, its focus continued to become more complex and its form more balanced. Individual differences in children's symbol-infused joint engagement were stable across 4 years. These findings highlight both how joint engagement is transformed as conversational skills develop and how it remains rooted in earlier interactions and supported by caregiver's actions.
C1 [Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Nelson, P. Brooke] Georgia State Univ, Atlanta, GA 30303 USA.
RP Adamson, LB (reprint author), Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA.
EM ladamson@gsu.edu
CR Adamson L. B., ENCY LANGUAGE DEV
Adamson L. B., 1996, COMMUNICATION DEV IN
Adamson LB, 2010, J AUTISM DEV DISORD, V40, P665, DOI 10.1007/s10803-009-0914-1
Adamson LB, 2012, J AUTISM DEV DISORD, V42, P2622, DOI 10.1007/s10803-012-1520-1
Adamson LB, 2004, CHILD DEV, V75, P1171, DOI 10.1111/j.1467-8624.2004.00732.x
Adamson LB, 2010, J SPEECH LANG HEAR R, V53, P1769, DOI 10.1044/1092-4388(2010/09-0208)
Adamson LB, 2009, J AUTISM DEV DISORD, V39, P84, DOI 10.1007/s10803-008-0601-7
Adamson LB, 2006, CHILD DEV, V77, P186, DOI 10.1111/j.1467-8624.2006.00864.x
BAKEMAN R, 1984, CHILD DEV, V55, P1278, DOI 10.2307/1129997
Bakeman R., 1997, OBSERVING INTERACTIO
Bartsch K., 1995, CHILDREN TALK MIND
Brown Roger, 1973, 1 LANGUAGE
Callaghan TC, 2002, CHILD DEV, V73, P359, DOI 10.1111/1467-8624.00412
Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
Charman T, 2002, SOC DEV, V11, P1, DOI 10.1111/1467-9507.00183
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
Dale PS, 2003, J SPEECH LANG HEAR R, V46, P544, DOI 10.1044/1092-4388(2003/044)
DeLoache JS, 2002, MINN SYM CHILD PSYCH, V32, P73
Doherty M., 2011, PERCEPTION CAUSATION, P305
DUNN J, 1987, DEV PSYCHOL, V23, P132, DOI 10.1037//0012-1649.23.1.132
Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
Eilan N., 2005, JOINT ATTENTION COMM
Ensor R, 2008, CHILD DEV, V79, P201, DOI 10.1111/j.1467-8624.2007.01120.x
Fenson L, 1993, MACARTHUR COMMUNICAT
Fivush R, 2006, CHILD DEV, V77, P1568, DOI 10.1111/j.1467-8624.2006.00960.x
Fivush R., 1997, DEV SPANS EVENT COMP, P169
Kaiser AP, 2011, J EARLY INTERVENTION, V33, P298, DOI 10.1177/1053815111429968
Kaplan H., 1963, SYMBOL FORMATION
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Masur EF, 2001, MERRILL PALMER QUART, V47, P100, DOI 10.1353/mpq.2001.0003
Melzi G, 2011, CHILD DEV, V82, P1282, DOI 10.1111/j.1467-8624.2011.01600.x
Moore C., 1995, JOINT ATTENTION ITS
Morford JP, 1997, CHILD DEV, V68, P420, DOI 10.2307/1131669
Mullen E, 1995, MULLEN SCALES EARLY
Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x
MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
Nelson K., 2008, YOUNG MINDS SOCIAL W
Nelson K., 1996, LANGUAGE COGNITIVE D
Nelson KD, 2004, PSYCHOL REV, V111, P486, DOI 10.1037/0033-295X.111.2.486
Nelson PB, 2012, SOC DEV, V21, P313, DOI 10.1111/j.1467-9507.2011.00638.x
Nelson PB, 2008, DEVELOPMENTAL SCI, V11, P847, DOI 10.1111/j.1467-7687.2008.00733.x
Perner J, 2007, INFANT CHILD DEV, V16, P471, DOI 10.1002/icd.517
Quera V., 2011, SEQUENTIAL ANAL OBSE
Rescorla L, 2000, J CHILD LANG, V27, P293, DOI 10.1017/S030500090000413X
Rogoff Barbara, 1990, APPRENTICESHIP THINK
Romski M, 2010, J SPEECH LANG HEAR R, V53, P350, DOI 10.1044/1092-4388(2009/08-0156)
Sander L., 1977, INTERACTION CONVERSA, P133
Seemann A, 2011, JOINT ATTENTION: NEW DEVELOPMENTS IN PSYCHOLOGY, PHILOSOPHY OF MIND, AND SOCIAL NEUROSCIENCE, P1
SIGEL IE, 1993, DEVELOPMENT AND MEANING OF PSYCHOLOGICAL DISTANCE, P141
Sigel I. E., 1970, MIAM S PRED BEH 1968, P99
Tare M, 2010, J APPL DEV PSYCHOL, V31, P395, DOI 10.1016/j.appdev.2010.06.005
Thal DJ, 1997, DEV NEUROPSYCHOL, V13, P239
Tomasello Michael, 2003, CONSTRUCTING LANGUAG
Tronick E. Z., 1979, SPEECH BEGINNING INT, P349
Tukey J.W., 1977, EXPLORATORY DATA ANA
Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
Williams K. T., 1997, EXPRESSIVE VOCABULAR
NR 58
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
EI 1467-8624
J9 CHILD DEV
JI Child Dev.
PD MAY
PY 2014
VL 85
IS 3
BP 941
EP 955
DI 10.1111/cdev.12187
PG 15
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA AH0CL
UT WOS:000335786600008
PM 24266591
ER
PT J
AU Winstone, N
Huntington, C
Goldsack, L
Kyrou, E
Millward, L
AF Winstone, Naomi
Huntington, Corinne
Goldsack, Lisa
Kyrou, Elli
Millward, Lynne
TI Eliciting rich dialogue through the use of activity-oriented interviews
Exploring self-identity in autistic young people
SO CHILDHOOD-A GLOBAL JOURNAL OF CHILD RESEARCH
LA English
DT Article
DE child-centred research methods; self-identity; interview; qualitative;
Autism
ID CHILDREN; MIND; IMPAIRMENTS; LANGUAGE; GENDER; ADULTS; LINKS; POWER; FUN
AB The ability of children and young people to form and express their perspectives through qualitative research studies can be constrained by difficulties that they can face in typical interview situations. This article describes and evaluates an interview method using concrete and engaging activities designed to enable autistic young people to voice their abilities and perspectives. Participants' sense of self-identity was explored using traditional semi-structured interviews and novel activity-oriented interviews. The latter method provided a context within which autistic young people were better able to voice their perspectives. The efficacy of this method and considerations for its use are discussed.
C1 [Winstone, Naomi; Goldsack, Lisa; Kyrou, Elli; Millward, Lynne] Univ Surrey, Guildford GU2 7XH, Surrey, England.
[Huntington, Corinne] Kings Coll Hosp London, London SE5 8RX, England.
RP Winstone, N (reprint author), Univ Surrey, Sch Psychol, Guildford GU2 7XH, Surrey, England.
EM N.Winstone@surrey.ac.uk
CR ARCHER SL, 1989, J ADOLESCENCE, V12, P117, DOI 10.1016/0140-1971(89)90003-1
Bagatell N, 2007, DISABIL SOC, V22, P413, DOI 10.1080/09687590701337967
Barker J., 2003, INT J SOCIOLOGY SOCI, V23, P33, DOI DOI 10.1108/01443330310790435
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Barrow W, 2012, SCHOOL PSYCHOL INT, V33, P450, DOI 10.1177/0143034311429167
Begley A, 2000, RES CHILDRENS PERSPE, P98
Bosacki SL, 2000, J EDUC PSYCHOL, V92, P709, DOI 10.1037//0022-0663.92.4.709
Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
Breakwell G. M., 2006, RES METHODS PSYCHOL, P232
Christensen P, 2008, RES CHILDREN PERSPEC, P156
Colucci E, 2007, QUAL HEALTH RES, V17, P1422, DOI 10.1177/1049732307308129
Cook T, 2007, CHILDHOOD, V14, P29, DOI 10.1177/0907568207068562
Crawford P, 2008, INT J NURS STUD, V45, P1055, DOI 10.1016/j.ijnurstu.2007.05.005
Curtis K., 2004, CHILD FAMILY SOCIAL, V9, P167, DOI 10.1111/j.1365-2206.2004.00304.x
Damon W., 1988, SELF UNDERSTANDING C
Daniel LS, 2010, FOCUS AUTISM DEV DIS, V25, P220, DOI 10.1177/1088357610378290
Darbyshire P, 2005, QUALITATIVE RES, V5, P417, DOI DOI 10.1177/1468794105056921
Davis J, 2008, RES CHILDREN PERSPEC, P220
Engel S, 1999, STORIES CHILDREN TEL
Hall K, 2001, ASPERGER SYNDROME UN
Holland S, 2010, CHILDHOOD, V17, P360, DOI 10.1177/0907568210369310
Hughes C, 2004, SOC DEV, V13, P590, DOI 10.1111/j.1467-9507.2004.00285.x
Lee A, 1998, J CHILD PSYCHOL PSYC, V39, P1131, DOI 10.1111/1469-7610.00417
LEWIS M, 1990, MERRILL PALMER QUART, V36, P93
Lundy L, 2012, CHILDHOOD, V19, P129, DOI 10.1177/0907568211409078
Mauthner M., 1997, CHILDREN SOC, V11, P16, DOI DOI 10.1111/J.1099-0860.1997.TB00003.X
Menzies R, 2011, ASSETS 11: PROCEEDINGS OF THE 13TH INTERNATIONAL ACM SIGACCESS CONFERENCE ON COMPUTERS AND ACCESSIBILITY, P273
Oakley A., 1994, CHILDRENS CHILDHOODS, P13
Pratt C, 1990, 1 LANGUAGE, V10, P167, DOI 10.1177/014272379001002905
Preece D., 2002, BRIT J LEARN DISABIL, V30, P97, DOI 10.1046/j.1468-3156.2002.00179.x
Priestley G, 1997, APPL COGNITIVE PSYCH, V11, P69, DOI 10.1002/(SICI)1099-0720(199702)11:1<69::AID-ACP426>3.0.CO;2-V
Punch S, 2002, CHILDHOOD, V9, P321, DOI 10.1177/0907568202009003005
Reddy V, 2010, AUTISM, V14, P531, DOI 10.1177/1362361310370397
Scott J., 2008, RES CHILDREN PERSPEC, V2nd, P87
Tager-Flusberg H, 1999, INT REV PSYCHIATR, V11, P325, DOI 10.1080/09540269974203
Wesson M, 2001, APPL COGNITIVE PSYCH, V15, P301, DOI 10.1002/acp.706
Williams D., 1992, NOBODY NOWHERE EXTRA
Williams E, 2004, THEOR PSYCHOL, V14, P704, DOI 10.1177/0959354304046180
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
Woodhead M., 2008, RES CHILDREN PERSPEC, V2nd, P10
Woodhouse B., 2004, RETHINKING CHILDHOOD, P229
NR 42
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0907-5682
EI 1461-7013
J9 CHILDHOOD
JI Child.-Glob. J. Child Res.
PD MAY
PY 2014
VL 21
IS 2
BP 190
EP 206
DI 10.1177/0907568213491771
PG 17
WC Social Sciences, Interdisciplinary
SC Social Sciences - Other Topics
GA AH0RN
UT WOS:000335828000004
ER
PT J
AU Juneja, M
Mishra, D
Russell, PSS
Gulati, S
Deshmukh, V
Tudu, P
Sagar, R
Silberberg, D
Bhutani, VK
Pinto, JM
Durkin, M
Pandey, RM
Nair, MKC
Arora, NK
AF Juneja, Monica
Mishra, Devendra
Russell, Paul S. S.
Gulati, Sheffali
Deshmukh, Vaishali
Tudu, Poma
Sagar, Rajesh
Silberberg, Donald
Bhutani, Vinod K.
Pinto, Jennifer M.
Durkin, Maureen
Pandey, Ravindra M.
Nair, M. K. C.
Arora, Narendra K.
CA INCLEN Study Grp
TI INCLEN diagnostic tool for autism spectrum disorder (INDT-ASD):
Development and validation
SO INDIAN PEDIATRICS
LA English
DT Article
DE Childhood; Neuro developmental disorders; Resource limited settings;
Childhood austism rating scale; Pervasive developmental disorders
ID SYMPTOM MODEL; FIELD TRIAL; DSM-IV; CRITERIA; CLASSIFICATION;
COMPONENTS; INTERVIEW; VALIDITY; CHILDREN; SCALE
AB To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD).
Diagnostic test evaluation by cross sectional design
Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India.
Children aged 2-9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard).
Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency.
154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P < 0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for' ASD group' was 82.52% [Cohen's kappa=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = -0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance.
INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder.
C1 [Juneja, Monica; Mishra, Devendra; Russell, Paul S. S.; Gulati, Sheffali; Deshmukh, Vaishali; Tudu, Poma; Sagar, Rajesh; Silberberg, Donald; Bhutani, Vinod K.; Pinto, Jennifer M.; Durkin, Maureen; Pandey, Ravindra M.; Nair, M. K. C.; Arora, Narendra K.; INCLEN Study Grp] INCLEN TRUST Int, New Delhi, India.
RP Arora, NK (reprint author), INCLEN TRUST Int, F1-5 Okhla Ind Area,Phase 1, New Delhi, India.
EM nkarora@inclentrust.org
RI Durkin, Maureen/B-7834-2015; Karande, Sunil/F-1835-2013
OI Karande, Sunil/0000-0002-1170-325X
FU Ministry of Social Justice and Empowerment (National Trust); National
Institute of Health (NIH-USA); Fogarty International Center (FIH);
Autism Speaks (USA)
FX Ministry of Social Justice and Empowerment (National Trust), National
Institute of Health (NIH-USA), Fogarty International Center (FIH), and
Autism Speaks (USA).
CR [Anonymous], 2002, INT CLASS DIS ICD 10
(APA) APA, 2000, DIAGN STAT MAN MENT
Bakare MO, 2011, SAJP-S AFR J PSYCHI, V17, P118
Boomsma A, 2008, J CHILD PSYCHOL PSYC, V49, P809, DOI 10.1111/j.1469-7610.2008.01897.x
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
de Bosset V, 2002, ENDOSCOPY, V34, P360, DOI 10.1055/s-2002-25277
Doll EA, 1935, AM J ORTHOPSYCHIAT, V5, P180
Fischer Russell G., 1978, J ACAD LIBR, V4, P64
Fitzpatrick R, 1998, Health Technol Assess, V2, P1
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Kulsrestha SK, 1971, STANFORD BINET INTEL
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
McColl E, 2001, Health Technol Assess, V5, P1
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Russell AJ, 2009, PSYCHOTHER PSYCHOSOM, V78, P59, DOI 10.1159/000172622
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Sell NK, 2012, DISABIL HEALTH J, V5, P9, DOI 10.1016/j.dhjo.2011.08.002
Sigman M, 2005, J AUTISM DEV DISORD, V35, P15, DOI 10.1007/s10803-004-1027-5
SPITZER RL, 1990, J AM ACAD CHILD PSY, V29, P855, DOI 10.1097/00004583-199011000-00003
Tadevosyan-Leyfer O, 2003, J AM ACAD CHILD PSY, V42, P864, DOI 10.1097/01.CHI.0000046870.56865.90
Tanguay PE, 1998, J AM ACAD CHILD PSY, V37, P271, DOI 10.1097/00004583-199803000-00011
van Lang NDJ, 2006, J CHILD PSYCHOL PSYC, V47, P37, DOI 10.1111/j.1469-7610.2005.01434.x
VOLKMAR FR, 1988, J AUTISM DEV DISORD, V18, P81, DOI 10.1007/BF02211820
Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
VOLKMAR FR, 1994, AM J PSYCHIAT, V151, P1361
NR 30
TC 3
Z9 3
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
INDIA
SN 0019-6061
EI 0974-7559
J9 INDIAN PEDIATR
JI Indian Pediatrics
PD MAY
PY 2014
VL 51
IS 5
BP 359
EP 365
DI 10.1007/s13312-014-0417-9
PG 7
WC Pediatrics
SC Pediatrics
GA AH3TZ
UT WOS:000336049800005
PM 24953575
ER
PT J
AU Brisson, J
Martel, K
Serres, J
Sirois, S
Adrien, JL
AF Brisson, Julie
Martel, Karine
Serres, Josette
Sirois, Sylvain
Adrien, Jean-Louis
TI ACOUSTIC ANALYSIS OF ORAL PRODUCTIONS OF INFANTS LATER DIAGNOSED WITH
AUTISM AND THEIR MOTHER
SO INFANT MENTAL HEALTH JOURNAL
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; FAMILY HOME MOVIES; SPECTRUM DISORDERS;
MATERNAL SPEECH; INTONATION CONTOURS; EARLY RECOGNITION;
ASPERGER-SYNDROME; YOUNG-CHILDREN; 1ST YEAR; PROSODY
AB Research on early signs of autism in social interactions often focuses on infants' motor behaviors; few studies have focused on speech characteristics. This study examines infant-directed speech of mothers of infants later diagnosed with autism (LDA; n = 12) or of typically developing infants (TD; n = 11) as well as infants' productions (13 LDA, 13 TD). Since LDA infants appear to behave differently in the first months of life, it can affect the functioning of dyadic interactions, especially the first vocal productions, sensitive to expressiveness and emotions sharing. We assumed that in the first 6 months of life, prosodic characteristics (mean duration, mean pitch, and intonative contour types) will be different in dyads with autism. We extracted infants' and mothers' vocal productions from family home movies and analyzed the mean duration and pitch as well as the pitch contours in interactive episodes. Results show that mothers of LDA infants use relatively shorter productions as compared to mothers talking to TD infants. LDA infants' productions are not different in duration or pitch, but they use less complex modulated productions (i.e., those with more than two melodic modulations) than do TD. Further studies should focus on developmental profiles in the first year, analyzing prosody monthly.
RESUMEN La investigacion sobre las tempranas senales de autismo en interacciones sociales a menudo se enfoca en la conducta motora de los infantes; pocos estudios se han enfocado en las caracteristicas del habla. Este estudio examina el habla dirigida a los infantes de madres cuyos infantes son diagnosticados con autismo posteriormente (LDA, n = 12) o de infantes que se desarrollan tipicamente (TD, n = 11), asi como las producciones de los infantes (13 LDA y 13 TD). El hecho de que los infantes LDA parecen comportarse diferentemente en su primer mes de vida puede afectar el funcionamiento de las interacciones diadicas, especialmente las primeras producciones vocales, sensibles a la expresividad y a compartir emociones. Asumimos que en los primeros seis meses de vida, las caracteristicas prosodicas (promedio de duracion, promedio de entonacion y tipos de curvas de entonacion) seran diferentes en diadas con autismo. Obtuvimos producciones vocales de los infantes y madres en videos caseros y analizamos el promedio de duracion y entonacion, asi como las curvas de entonacion en episodios interactivos. Los resultados muestran que las madres de infantes LDA usan producciones relativamente mas cortas comparadas con las madres que le hablan a infantes del grupo TD. Las producciones de los infantes LDA no son diferentes en duracion o entonacion, pero ellos usan producciones moduladas (las que tienen mas de dos modulaciones melodicas) menos complejas que las de los infantes con desarrollo tipico. Estudios posteriores deben enfocarse en perfiles de desarrollo en el primer ano, analizando cada mes la prosodia.
RESUME La recherche sur les signes precoces d'autisme dans les interactions sociales met souvent l'accent sur les comportements moteurs des nourrissons. Peu d'etudes mettent l'accent sur les caracteristiques vocales. Cette etude examine les paroles dirigees vers le nourrisson des meres de bebes plus tard diagnostiques avec un autisme (abreges selon l'anglais LDA, n = 12) ou d'un bebe se developpant de maniere typique (abreges selon l'anglais TD, n = 11), ainsi que les productions des nourrissons (13 LDA et 13 TD). Puisque les bebes LDA semblent se comporter differemment dans les premiers mois de leur vie, cela peut affecter le fonctionnement d'interactions dyadiques, surtout les premieres productions vocales, la partage d'emotions et la sensibilite a l'expression. Nous supposons que dans les six premiers mois de la vie les caracteristiques prosodiques (duree moyenne, hauteur moyenne de la voix, types de contour de l'intonation) sont differentes chez les dyades avec un autisme. Nous avons extrait les productions vocales de bebes et de meres dans des videos familiales et analyse la duree moyenne et la voix moyenne, ainsi que les contours de voix dans des episodes d'interaction. Les resultats montrent que les meres de bebes LDA utilisent des productions relativement plus courtes que ne le font les meres parlant a des bebes TD. Les productions de bebes LDA n'etaient differentes ni en duree ni en voix mais utilisaient des productions modulees moins complexes (pour ce qui concerne ceux qui faisaient etat de plus de deux modulations melodiques) que les bebes se developpant de maniere typique. Plus d'etudes devraient se pencher sur les profils de developpement dans la premiere annee, en analysant la prosodie mensuellement.
ZUSAMMENFASSUNG Forschung uber fruhe Anzeichen von Autismus in sozialen Interaktionen fokussiert oft auf motorische Verhaltensweisen von Sauglingen, nur wenige Studien legten den Fokus auf Sprachmerkmale. Diese Studie untersucht die an den Saugling gerichtete Sprache der Mutter von Sauglingen mit spater diagnostiziertem Autismus (LDA (later diagnosed with autism), n = 12) oder von normal entwickelten Sauglingen (TD (typically developing), n = 11) sowie die stimmlichen Produktionen der Sauglinge (13 LDA und 13 TD). LDA-Sauglinge scheinen sich im ersten Lebensmonat anders zu verhalten. Dieses Verhalten kann dyadische Interaktionen beeinflussen, vor allem die ersten stimmlichen Produktionen, die mit Ausdrucksfahigkeit und geteilten Emotionen zusammenhangen. Wir gehen davon aus, dass in den ersten sechs Lebensmonaten prosodische Merkmale (mittlere Dauer, mittlere Tonhohe und Tonhohenkonturen) in Dyaden mit Autismus anders sein werden. Wir extrahierten stimmliche Produktionen von Sauglingen und Muttern aus Familienvideos und analysierten die mittlere Dauer, Tonhohe und die Tonhohenkonturen anhand interaktiver Episoden. Die Ergebnisse zeigen, dass Mutter von LDA-Sauglingen vergleichsweise kurzere Produktionen verwenden als Mutter die zu ihren TD-Sauglingen sprechen. Produktionen von LDA-Sauglingen unterscheiden sich nicht in Dauer oder Tonhohe, aber sie verwenden weniger komplex modulierte Produktionen (mit mehr als zwei melodischen Modulationen) als normal entwickelte Sauglingen. Weitere Studien sollten auf die Entwicklungsprofile im ersten Jahr fokussieren und dabei die Prosodie monatlich analysieren.
ABSTRACT Research on early signs of autism in social interactions often focuses on infants' motor behaviors; few studies focused on speech characteristics. This study examines infant-directed speech of mothers of infants later diagnosed with autism (LDA, n = 12) or of typically developing infant (TD, n = 11), as well as infants' productions (13 LDA and 13 TD). ?????????????????????????????????????????????????????????????????????????????????????????????(LDA, n = 12)???????????????(TD, n = 11)??????????????????????????(13 LDA and 13 TD)??????LAD?????????1????????????????????????????????????????????????????????????????????6????????????prosodic characteristics(??????????????????????????????)?????????????????????????????????????????????????????????????????????????????????????????????????LDA???????TD?????????????????????????????????????????LDA????????????????????????????????????????????????????(?????????????????)?????????????????????prosody???????????1??????????????????????
C1 [Brisson, Julie; Serres, Josette; Adrien, Jean-Louis] Univ Paris Descartes Sorbonne Cite, Paris, France.
[Brisson, Julie; Sirois, Sylvain] Univ Quebec Trois Rivieres, Trois Rivieres, PQ GA9 5H7, Canada.
[Martel, Karine] Univ Caen Basse Normandie, Caen, France.
RP Brisson, J (reprint author), Univ Rouen, Lab PSY Nca, Rue Lavoisier, F-76821 Mont St Aignan, France.
EM julie_brisson@yahoo.fr
CR Adamson LB, 2010, J AUTISM DEV DISORD, V40, P665, DOI 10.1007/s10803-009-0914-1
Adrien J. L., 1991, ACTA PAEDOPSYCHIATIC, V55, P59
Adrien J. L., 1991, Brain Dysfunction, V4, P355
ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
ADRIEN JL, 1991, J AUTISM DEV DISORD, V21, P43, DOI 10.1007/BF02206996
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baltaxe C., 1984, P 10 INT C PHON SCI, P713
BATESON MC, 1975, ANN NY ACAD SCI, V263, P101, DOI 10.1111/j.1749-6632.1975.tb41575.x
BERTONCINI J, 1987, J ACOUST SOC AM, V82, P31, DOI 10.1121/1.395570
BLOOM K, 1988, J CHILD LANG, V15, P469
Boersma P., 2007, PRAAT DOING PHONETIC
Bonneh YS, 2011, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00237
Christophe A, 2001, INFANCY, V2, P385, DOI 10.1207/S15327078IN0203_6
Cohen D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061402
Cruttenden Alan, 1997, INTONATION, V2nd
CUTLER A, 1987, J CHILD LANG, V14, P145
Danon-Boileau L., 2007, SIGNS AUTISM INFANTS, P63
D'Odorico L., 2009, ENFANCE, V61, P317
Dawson G, 2000, J APPL DEV PSYCHOL, V21, P299, DOI 10.1016/S0193-3973(99)00042-8
Demuth K., 1995, P N E LINGUISTIC SOC, P13
Fagan MK, 2007, INFANCY, V11, P191
FERNALD A, 1984, DEV PSYCHOL, V20, P104, DOI 10.1037//0012-1649.20.1.104
Fosnot S. M., 1999, P 14 INT C PHON SCI, P1925
Garnica O. K., 1977, TALKING CHILDREN LAN, P63
Gratier M, 2011, DEV PSYCHOL, V47, P67, DOI 10.1037/a0020722
Grossman RB, 2010, J SPEECH LANG HEAR R, V53, P778, DOI 10.1044/1092-4388(2009/08-0127)
Hohle B, 2009, INFANT BEHAV DEV, V32, P262, DOI 10.1016/j.infbeh.2009.03.004
Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
Hsu HC, 2001, INFANT BEHAV DEV, V24, P107, DOI 10.1016/S0163-6383(01)00061-3
Jardri R, 2012, INT J DEV NEUROSCI, V30, P159, DOI 10.1016/j.ijdevneu.2011.11.002
Josse D., 2001, MANUEL BRUNET LEZINE
Kisilevsky BS, 2009, INFANT BEHAV DEV, V32, P59, DOI 10.1016/j.infbeh.2008.10.002
Kitamura C, 2003, INFANCY, V4, P85, DOI 10.1207/S15327078IN0401_5
Laznick M. C., 2007, SIGNS AUTISM INFANTS, P139
Lewitt A. G., 1993, HASKINS LAB STATUS R, P41
LYNCH MP, 1995, DEV PSYCHOBIOL, V28, P3, DOI 10.1002/dev.420280103
Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
Maestro S, 2005, CHILD PSYCHIAT HUM D, V35, P383, DOI 10.1007/s10578-005-2695-x
Mahdhaoui A, 2011, INT J METH PSYCH RES, V20, pE6, DOI 10.1002/mpr.332
McCann J, 2003, INT J LANG COMM DIS, V38, P325, DOI 10.1080/1368282031000154204
Muratori F., 2007, INT J DIALOGICAL SCI, V2, P93
Nazzi T, 1998, J EXP PSYCHOL HUMAN, V24, P756, DOI 10.1037//0096-1523.24.3.756
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12
Perron-Borelli M., 1997, ECHELLES DIFFERENTIE
Prieto P., 2011, J CHILD LANG, V39, P221
Ricks D., 1979, SPEECH BEGINNING INT, P245
Schoen E., 2011, AUTISM RES, V4, P1
Schopler E., 1988, CHILDHOOD AUTISM RAT
Schopler E., 1997, PROFIL PSYCHO ED PEP
Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155
Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
Smith NA, 2008, INFANCY, V13, P410, DOI 10.1080/15250000802188719
Stern D., 1985, INTERPERSONAL WORLD
STERN DN, 1983, J CHILD LANG, V10, P1
STERN DN, 1982, DEV PSYCHOL, V18, P727
TAGERFLUSBERG H, 1990, J CHILD LANG, V17, P591
Trevarthen C, 2005, BRAIN DEV-JPN, V27, pS25, DOI 10.1016/j.braindev.2005.03.016
Warren SF, 2010, J AUTISM DEV DISORD, V40, P555, DOI 10.1007/s10803-009-0902-5
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
World Health Organization, 1994, INT CLASS DIS
NR 64
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0163-9641
EI 1097-0355
J9 INFANT MENT HEALTH J
JI Infant Ment. Health J.
PD MAY
PY 2014
VL 35
IS 3
BP 285
EP 295
DI 10.1002/imhj.21442
PG 11
WC Psychology, Developmental
SC Psychology
GA AF4IB
UT WOS:000334674100008
PM 25798482
ER
PT J
AU Goch, CJ
Stieltjes, B
Henze, R
Hering, J
Poustka, L
Meinzer, HP
Maier-Hein, KH
AF Goch, Caspar J.
Stieltjes, Bram
Henze, Romy
Hering, Jan
Poustka, Luise
Meinzer, Hans-Peter
Maier-Hein, Klaus H.
TI Quantification of changes in language-related brain areas in autism
spectrum disorders using large-scale network analysis
SO INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
LA English
DT Article
DE Connectomics; Network analysis; Diffusion imaging; Autism spectrum
disorder; Open-source
ID HIGH-FUNCTIONING AUTISM; HUMAN CEREBRAL-CORTEX; WHITE-MATTER; DIAGNOSTIC
INTERVIEW; ASPERGER-SYNDROME; CHILDREN; LATERALIZATION; CLASSIFICATION;
CONNECTOMICS; ORGANIZATION
AB Diagnosis of autism spectrum disorders (ASD) is difficult, as symptoms vary greatly and are difficult to quantify objectively. Recent work has focused on the assessment of non-invasive diffusion tensor imaging-based biomarkers that reflect the microstructural characteristics of neuronal pathways in the brain. While tractography-based approaches typically analyze specific structures of interest, a graph-based large-scale network analysis of the connectome can yield comprehensive measures of larger-scale architectural patterns in the brain. Commonly applied global network indices, however, do not provide any specificity with respect to functional areas or anatomical structures. Aim of this work was to assess the concept of network centrality as a tool to perform locally specific analysis without disregarding the global network architecture and compare it to other popular network indices.
We create connectome networks from fiber tractographies and parcellations of the human brain and compute global network indices as well as local indices for Wernicke's Area, Broca's Area and the Motor Cortex. Our approach was evaluated on 18 children suffering from ASD and 18 typically developed controls using magnetic resonance imaging-based cortical parcellations in combination with diffusion tensor imaging tractography.
We show that the network centrality of Wernicke's area is significantly (p 0.001) reduced in ASD, while the motor cortex, which was used as a control region, did not show significant alterations. This could reflect the reduced capacity for comprehension of language in ASD.
The betweenness centrality could potentially be an important metric in the development of future diagnostic tools in the clinical context of ASD diagnosis. Our results further demonstrate the applicability of large-scale network analysis tools in the domain of region-specific analysis with a potential application in many different psychological disorders.
C1 [Goch, Caspar J.; Stieltjes, Bram; Hering, Jan; Meinzer, Hans-Peter; Maier-Hein, Klaus H.] German Canc Res Ctr, D-69120 Heidelberg, Germany.
[Henze, Romy] Univ Heidelberg Hosp, D-69115 Heidelberg, Germany.
[Poustka, Luise] Heidelberg Univ, Cent Inst Mental Hlth, Clin Fac Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
RP Goch, CJ (reprint author), German Canc Res Ctr, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
EM c.goch@dkfz.de; k.maier-hein@dkfz.de
FU Helmholtz International Graduate School for Cancer Research; German
Research Foundation (DFG) [ME 833/15-1]
FX This study was in part financed by the Helmholtz International Graduate
School for Cancer Research. Dr. Maier-Hein (ne Fritzsche) received
support from the German Research Foundation (DFG), Grant ME 833/15-1.
CR Aoki Y, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-25
Baio J, 2012, MORBIDITY MORTALITY
Barttfeld P, 2012, NEUROPSYCHOLOGIA, V50, P3653, DOI 10.1016/j.neuropsychologia.2012.09.047
Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
Buckner RL, 2009, J NEUROSCI, V29, P1860, DOI 10.1523/JNEUROSCI.5062-08.2009
Bullmore ET, 2009, NAT REV NEUROSCI, V10, P186, DOI 10.1038/nrn2575
Burns MS, 2010, TOP STROKE REHABIL, V17, P401, DOI 10.1310/tsr1706-401
Cauda F, 2014, HUM BRAIN MAPP, V35, P2073, DOI 10.1002/hbm.22313
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Dehaene-Lambertz G, 2006, P NATL ACAD SCI USA, V103, P14240, DOI 10.1073/pnas.0606302103
Desikan RS, 2006, NEUROIMAGE, V31, P968, DOI 10.1016/j.neuroimage.2006.01.021
DeWitt I, 2012, P NATL ACAD SCI USA, V109, pE505, DOI 10.1073/pnas.1113427109
Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
Fischl B, 2004, CEREB CORTEX, V14, P11, DOI 10.1093/cercor/bhg087
Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083
Ford AA, 2013, FRONT NEUROANAT, V7, DOI 10.3389/fnana.2013.00008
Fornito A, 2013, NEUROIMAGE, V80, P426, DOI 10.1016/j.neuroimage.2013.04.087
FREEMAN LC, 1977, SOCIOMETRY, V40, P35, DOI 10.2307/3033543
Fritzsche KH, 2012, METHOD INFORM MED, V51, P441, DOI 10.3414/ME11-02-0031
Goch C, 2013, BILDVERARBEITUNG MED, P51
Gotts SJ, 2013, P NATL ACAD SCI USA, V110, pE3435, DOI 10.1073/pnas.1302581110
Greimel E, 2013, BRAIN STRUCT FUNCT, V218, P929, DOI 10.1007/s00429-012-0439-9
Griffa A, 2013, NEUROIMAGE, V80, P515, DOI 10.1016/j.neuroimage.2013.04.056
Groen WB, 2010, CEREB CORTEX, V20, P1937, DOI 10.1093/cercor/bhp264
Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Ingalhalikar M, 2011, NEUROIMAGE, V57, P918, DOI 10.1016/j.neuroimage.2011.05.023
Jakab A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060982
Jenkinson M, 2012, NEUROIMAGE, V62, P782, DOI 10.1016/j.neuroimage.2011.09.015
Johansen-Berg H, 2013, NEUROIMAGE, V80, P541, DOI 10.1016/j.neuroimage.2013.05.082
Joseph RM, 2013, BRAIN IMAGING BEHAV, P1
Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042
Lee JE, 2009, NEUROIMAGE, V44, P870, DOI 10.1016/j.neuroimage.2008.09.041
Lewis WW, 2012, CEREB CORTEX, V23, P1526
Li H., 2012, HUM BRAIN MAPP, DOI [10.1002/hbm.22185, DOI 10.1002/HBM.22185]
Li YH, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000395
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
McGrath J, 2013, AUTISM RES, V6, P307, DOI 10.1002/aur.1290
Mills BD, 2013, NEUROPSYCHOLOGIA, V51, P1933, DOI 10.1016/j.neuropsychologia.2013.06.012
Mueller S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067329
Nebel MB, 2012, HUM BRAIN MAPP, V35, P567
Neher PF, 2012, SPIE MED IMAGING 201
Nolden M, 2013, INT J COMPUT ASS RAD, V8, P607, DOI 10.1007/s11548-013-0840-8
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Poustka L, 2012, WORLD J BIOL PSYCHIA, V13, P269, DOI 10.3109/15622975.2011.591824
Raven J. C., 1995, COLOURED PROGR MATRI
Rinehart NJ, 2002, AUST NZ J PSYCHIAT, V36, P762, DOI 10.1046/j.1440-1614.2002.01097.x
Roine U, 2013, AUTISM RES, V6, P642, DOI 10.1002/aur.1332
Segonne F, 2004, NEUROIMAGE, V22, P1060, DOI 10.1016/j.neuroimage.2004.03.032
Seo EH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053922
Sporns O, 2013, NEUROIMAGE, V80, P53, DOI 10.1016/j.neuroimage.2013.03.023
Szaflarski JP, 2012, BRAIN RES, V1433, P85, DOI 10.1016/j.brainres.2011.11.026
Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014
Walker L, 2012, BIOL PSYCHIAT, V72, P1043, DOI 10.1016/j.biopsych.2012.08.001
NR 57
TC 2
Z9 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-6410
EI 1861-6429
J9 INT J COMPUT ASS RAD
JI Int. J. Comput. Assist. Radiol. Surg.
PD MAY
PY 2014
VL 9
IS 3
SI SI
BP 357
EP 365
DI 10.1007/s11548-014-0977-0
PG 9
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging;
Surgery
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging; Surgery
GA AH8KP
UT WOS:000336387000003
PM 24459035
ER
PT J
AU Nishiyama, T
Suzuki, M
Adachi, K
Sumi, S
Okada, K
Kishino, H
Sakai, S
Kamio, Y
Kojima, M
Suzuki, S
Kanne, SM
AF Nishiyama, Takeshi
Suzuki, Masako
Adachi, Katsunori
Sumi, Satoshi
Okada, Kensuke
Kishino, Hirohisa
Sakai, Saeko
Kamio, Yoko
Kojima, Masayo
Suzuki, Sadao
Kanne, Stephen M.
TI Comprehensive Comparison of Self-administered Questionnaires for
Measuring Quantitative Autistic Traits in Adults
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Quantitative autistic traits (QAT); Broader autism phenotype (BAP);
Autism spectrum disorder (ASD); Reliability; Validity
ID SPECTRUM QUOTIENT AQ; PERVASIVE DEVELOPMENTAL DISORDERS; EPWORTH
SLEEPINESS SCALE; BRIEF SYMPTOM INVENTORY; JAPANESE VERSION;
FAMILY-HISTORY; HEALTH SURVEY; SOCIAL IMPAIRMENT; PATIENT GROUPS; DATA
QUALITY
AB We comprehensively compared all available questionnaires for measuring quantitative autistic traits (QATs) in terms of reliability and construct validity in 3,147 non-clinical and 60 clinical subjects with normal intelligence. We examined four full-length forms, the Subthreshold Autism Trait Questionnaire (SATQ), the Broader Autism Phenotype Questionnaire, the Social Responsiveness Scale2-Adult Self report (SRS2-AS), and the Autism-Spectrum Quotient (AQ). The SRS2-AS and the AQ each had several short forms that we also examined, bringing the total to 11 forms. Though all QAT questionnaires showed acceptable levels of test-re-test reliability, the AQ and SRS2-AS, including their short forms, exhibited poor internal consistency and discriminant validity, respectively. The SATQ excelled in terms of classical test theory and due to its short length.
C1 [Nishiyama, Takeshi] Aichi Med Univ, Dept Publ Hlth, Nagakute, Aichi 4801195, Japan.
[Suzuki, Masako] Nagoya City Univ, Grad Sch Med Sci, Dept Psychiat, Nagoya, Aichi, Japan.
[Adachi, Katsunori] Nagoya City Univ, Sch Nursing, Dept Psychiat & Mental Hlth Nursing, Nagoya, Aichi, Japan.
[Sumi, Satoshi] Nagoya Western Rehabil Ctr Children Disabil, Dept Pediat, Nagoya, Aichi, Japan.
[Okada, Kensuke] Senshu Univ, Dept Psychol, Tokyo, Japan.
[Kishino, Hirohisa] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Biometry & Bioinformat, Tokyo, Japan.
[Sakai, Saeko] Osaka Univ, United Grad Sch Child Dev, Dept Child Dev, Osaka, Japan.
[Kamio, Yoko] Natl Ctr Neurol & Psychiat, Dept Child & Adolescent Mental Hlth, Tokyo, Japan.
[Kojima, Masayo; Suzuki, Sadao] Nagoya City Univ, Dept Publ Hlth, Grad Sch Med Sci, Nagoya, Aichi, Japan.
[Kanne, Stephen M.] Univ Missouri, Dept Hlth Psychol, Thompson Ctr Autism & Neurodev Disorder, Columbia, MO USA.
RP Nishiyama, T (reprint author), Aichi Med Univ, Dept Publ Hlth, 1-1 Yazako, Nagakute, Aichi 4801195, Japan.
EM nishiyama@minos.ocn.ne.jp
CR Allison C, 2012, J AM ACAD CHILD PSY, V51, P202, DOI 10.1016/j.jaac.2011.11.003
Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
Boulet J., 1991, PSYCHOL ASSESSMENT J, V3, P433, DOI [10.1037/1040-3590.3.3.433, DOI 10.1037/1040-3590.3.3.433]
Brugha TS, 2012, PSYCHOL MED, V42, P647, DOI 10.1017/S0033291711001292
CAMPBELL DT, 1959, PSYCHOL BULL, V56, P81, DOI 10.1037/h0046016
Constantino J. N., 2012, SOCIAL RESPONSIVENES, Vsecond
Constantino JN, 2007, J AM ACAD CHILD PSY, V46, P1668, DOI 10.1097/chi.0b013e318157cb23
Constantino JN, 2009, DEV PSYCHOPATHOL, V21, P127, DOI 10.1017/S095457940900008X
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Davidson J, 2014, J AUTISM DEV DISORD, V44, P2392, DOI 10.1007/s10803-012-1492-1
DELONG ER, 1988, BIOMETRICS, V44, P837, DOI 10.2307/2531595
Derogatis LR, 1977, SCL 90R REVISED VERS
DEROGATIS LR, 1983, PSYCHOL MED, V13, P595
Duku E, 2013, J AUTISM DEV DISORD, V43, P860, DOI 10.1007/s10803-012-1627-4
Efron B., 1994, INTRO BOOTSTRAP CHAP
Fleiss JL, 1999, DESIGN ANAL CLIN EXP
FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
Froom P, 1999, J CLIN EPIDEMIOL, V52, P731, DOI 10.1016/S0895-4356(99)00070-0
Fujita K., 2006, JAPANESE VERSION WAI
Fukuhara S., 2004, MANUAL SF 36V2 JAPAN
Fukuhara S, 1998, J CLIN EPIDEMIOL, V51, P1037, DOI 10.1016/S0895-4356(98)00095-X
Furukawa TA, 2008, INT J METH PSYCH RES, V17, P152, DOI 10.1002/mpr.257
Gamer M., 2010, IRR VARIOUS COEFFICE
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Hoekstra RA, 2011, J AUTISM DEV DISORD, V41, P589, DOI 10.1007/s10803-010-1073-0
Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
Hurst RM, 2007, J AUTISM DEV DISORD, V37, P1711, DOI 10.1007/s10803-006-0302-z
Ingersoll B, 2011, J AUTISM DEV DISORD, V41, P1646, DOI 10.1007/s10803-011-1192-2
Japanese version of WISC III and Publication Committee, 1998, JAP VERS WISC 3
JOHNS MW, 1991, SLEEP, V14, P540
Kanne SM, 2012, J AUTISM DEV DISORD, V42, P769, DOI 10.1007/s10803-011-1308-8
Kanne SM, 2009, J AUTISM DEV DISORD, V39, P827, DOI 10.1007/s10803-008-0688-x
Kanner L, 1943, NERV CHILD, V2, P217
Kawakami N., 1993, JAPANESE J HYGINE, V48, P401
Kessler RC, 2002, PSYCHOL MED, V32, P959, DOI 10.1017/S0033291702006074
KIRSHNER B, 1985, J CHRON DIS, V38, P27, DOI 10.1016/0021-9681(85)90005-0
Kloosterman PH, 2011, PERS INDIV DIFFER, V50, P310, DOI 10.1016/j.paid.2010.10.015
Kurita H, 2005, PSYCHIAT CLIN NEUROS, V59, P490, DOI 10.1111/j.1440-1819.2005.01403.x
Lau WYP, 2013, RES DEV DISABIL, V34, P294, DOI 10.1016/j.ridd.2012.08.005
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
MAYFIELD D, 1974, AM J PSYCHIAT, V131, P1121
McGraw KO, 1996, PSYCHOL METHODS, V1, P30, DOI 10.1037/1082-989X.1.4.390
MCHORNEY CA, 1994, MED CARE, V32, P40, DOI 10.1097/00005650-199401000-00004
MESSICK S, 1995, AM PSYCHOL, V50, P741, DOI 10.1037/0003-066X.50.9.741
Micali N, 2004, AUTISM, V8, P21, DOI 10.1177/1362361304040636
Nunnally J. C., 1994, PSYCHOMETRIC THEORY
PIERSMA HL, 1994, J PERS ASSESS, V63, P338, DOI 10.1207/s15327752jpa6302_12
Piven J, 1997, AM J PSYCHIAT, V154, P185
PIVEN J, 1990, J AM ACAD CHILD PSY, V29, P177, DOI 10.1097/00004583-199003000-00004
Podsakoff PM, 2003, J APPL PSYCHOL, V88, P879, DOI 10.1037/0021-9101.88.5.879
R Development Core Team, 2012, R LANG ENV STAT COMP
RANSOHOFF DF, 1978, NEW ENGL J MED, V299, P926, DOI 10.1056/NEJM197810262991705
Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
Rizopoulos D., 2006, J STAT SOFTW, V17, P1, DOI DOI 10.1360/J0S170001
Robin X, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-77
Ruta L, 2012, J AUTISM DEV DISORD, V42, P625, DOI 10.1007/s10803-011-1290-1
SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420
St Pourcain Beate, 2010, Am J Psychiatry, V167, P1364, DOI 10.1176/appi.ajp.2010.09121789
STEIGER JH, 1980, PSYCHOL BULL, V87, P245, DOI 10.1037//0033-2909.87.2.245
Streiner DL, 2008, HLTH MEASUREMENT SCA, VFourth
Takegami M, 2009, SLEEP MED, V10, P556, DOI 10.1016/j.sleep.2008.04.015
Tanaka Institute of Education, 1987, TAN BIN INT SCAL
Tomioka Mitsunao, 2008, Biopsychosoc Med, V2, P19, DOI 10.1186/1751-0759-2-19
Wakabayashi A, 2006, PERS INDIV DIFFER, V41, P873, DOI 10.1016/j.paid.2006.04.003
Wakabayashi A, 2006, J AUTISM DEV DISORD, V36, P263, DOI 10.1007/s10803-005-0061-2
Ware JE, 2000, SCORE VERSION 2 SF 3
Ware JE, 1998, J CLIN EPIDEMIOL, V51, P945, DOI 10.1016/S0895-4356(98)00085-7
WATSON D, 1984, PSYCHOL BULL, V96, P465, DOI 10.1037/0033-2909.96.3.465
Wild D, 2005, VALUE HEALTH, V8, P94, DOI 10.1111/j.1524-4733.2005.04054.x
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 76
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 993
EP 1007
DI 10.1007/s10803-013-2020-7
PG 15
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200001
PM 24342972
ER
PT J
AU Gardiner, E
Iarocci, G
AF Gardiner, Emily
Iarocci, Grace
TI Students with Autism Spectrum Disorder in the University Context: Peer
Acceptance Predicts Intention to Volunteer
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Acceptance; Post-secondary education;
Behavioral intent; Peers
ID POSTSECONDARY EDUCATION; INTELLECTUAL DISABILITIES; CHILDRENS ATTITUDES;
COMMUNITY-SERVICE; COLLEGE-STUDENTS; PERCEPTIONS; SCHIZOPHRENIA; ADULTS;
TRANSITION; YOUTH
AB With growing numbers of individuals with autism spectrum disorder (ASD) entering post-secondary institutions, strategies are needed to facilitate the social integration of these students. The goal of this study was to examine the role of various factors in university students' acceptance of, and intention to volunteer with, a peer with ASD. Both contact quantity and quality emerged as significant predictors of acceptance; however, for those who had experienced direct contact with individuals with ASD, only perceived quality emerged as significant. Moreover, acceptance played a significant role in participants' likelihood of signing up to volunteer. These findings point to the central role that positive experiences play in attitude formation for this population.
C1 [Gardiner, Emily; Iarocci, Grace] Simon Fraser Univ, Dept Psychol, Burnaby, BC V5A 1S6, Canada.
RP Gardiner, E (reprint author), Simon Fraser Univ, Dept Psychol, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada.
EM emily_gardiner@sfu.ca
CR Ahlborn LJ, 2008, RES DEV DISABIL, V29, P61, DOI 10.1016/j.ridd.2006.11.001
Antonio AL, 2000, REV HIGH EDUC, V23, P373
AUCC (Association of Universities and Colleges of Canada), 2011, TRENDS HIGH ED
Balswick T. O., 2005, RECIPROCATING SELF H
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Campbell DG, 1996, J AUTISM DEV DISORD, V26, P621, DOI 10.1007/BF02172351
Campbell JM, 2004, RES DEV DISABIL, V25, P321, DOI 10.1016/j.ridd.2004.01.005
Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075
Chitiyo M., 2011, J RES SPECIAL ED NEE, V11, P70, DOI 10.1111/j.1471-3802.2010.01181.x
Cruce T. M., 2006, ANN FOR ASS I RES CH
FORTINI ME, 1987, AM J MENT RETARD, V92, P78
Geller L. L., 2012, SOCIAL WORK MENTAL H, V8, P92
Griffin MM, 2012, J POLICY PRACT INTEL, V9, P234, DOI 10.1111/jppi.12008
Gus L., 2000, ED PSYCHOL PRACTICE, V16, P461, DOI 10.1080/713666109
Hall H, 1999, J DEV PHYS DISABIL, V11, P61, DOI 10.1023/A:1021812702337
Harnum M, 2007, J AUTISM DEV DISORD, V37, P1337, DOI 10.1007/s10803-006-0273-0
Hart D, 2010, FOCUS AUTISM DEV DIS, V25, P134, DOI 10.1177/1088357610373759
Helps S, 1999, AUTISM, V3, P287, DOI 10.1177/1362361399003003006
Holmes EP, 1999, SCHIZOPHRENIA BULL, V25, P447
Iobst E, 2009, RES AUTISM SPECT DIS, V3, P401, DOI 10.1016/j.rasd.2008.08.006
Ison N, 2010, DEV NEUROREHABIL, V13, P360, DOI 10.3109/17518423.2010.496764
Kamps D. M., 1998, J ED TREATMENT CHILD, V21, P107
MacDonald J. D., 1999, J DEV DISABILITIES, V6, P15
Mahoney D., 2008, THESIS U N CAROLINA
Marks HM, 2004, J HIGH EDUC, V75, P307, DOI 10.1353/jhe.2004.0015
May C, 2012, J POLICY PRACT INTEL, V9, P240, DOI 10.1111/jppi.12013
McGregor E, 2001, AUTISM, V5, P189
MCHALE SM, 1980, AM J MENT DEF, V85, P18
McManus J. L., 2010, J SOCIAL PERSONAL RE, V28, P579
Morton JE, 2008, RES DEV DISABIL, V29, P189, DOI 10.1016/j.ridd.2007.02.006
Nevill REA, 2011, J AUTISM DEV DISORD, V41, P1619, DOI 10.1007/s10803-011-1189-x
Park M., 2010, J RES SPECIAL ED NEE, V10, P107
Penn DL, 2001, SCHIZOPHRENIA BULL, V27, P197
Penn DL, 2003, SCHIZOPHRENIA BULL, V29, P383
PRATHER JH, 1984, PSYCHOL REP, V55, P887
Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
Statistics Canada, 2012, VOL RAT DISTR VOL HO
Stevens J. P., 2009, APPL MULTIVARIATE ST, V5th
Stodden RA, 2004, EDUC TRAIN DEV DISAB, V39, P3
STONE WL, 1987, J PEDIATR PSYCHOL, V12, P615, DOI 10.1093/jpepsy/12.4.615
Swaim KF, 2001, J AUTISM DEV DISORD, V31, P195, DOI 10.1023/A:1010703316365
Swiezy N., 2005, AUTISM KNOWLEDGE SUR
Teaching and Learning Centre, 2011, SFU STUD PRES SURV T
Welkowitz L. A., 2010, ASPERGERS SYNFROME I, P173
Whitaker P., 1998, BR J SPEC ED, V25, P60, DOI 10.1111/1467-8527.t01-1-00058
White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
World Health Organization (WHO), 2002, COMM LANG FUNCT DIS
NR 47
TC 2
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1008
EP 1017
DI 10.1007/s10803-013-1950-4
PG 10
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200002
PM 24077739
ER
PT J
AU Walsh, JA
Vida, MD
Rutherford, MD
AF Walsh, Jennifer A.
Vida, Mark D.
Rutherford, M. D.
TI Strategies for Perceiving Facial Expressions in Adults with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ASD; Face perception; Emotion perception; Perceptual strategies
ID CHILDREN; PERCEPTION; EMOTIONS; DEFICITS; FACES
AB Rutherford and McIntosh (J Autism Dev Disord 37: 187-196, 2007) demonstrated that individuals with autism spectrum disorder (ASD) are more tolerant than controls of exaggerated schematic facial expressions, suggesting that they may use an alternative strategy when processing emotional expressions. The current study was designed to test this finding using photographs of real people. In addition, two control tasks were added to eliminate alternative explanations. We replicated the findings of Rutherford and McIntosh (J Autism Dev Disord 37: 187-196, 2007) and also demonstrated that adults with ASD do not show this tolerance when evaluating how realistic the expressions are. These results suggest adults with ASD employ a rule-based strategy to a greater extent than typical adults when processing facial expressions but not when processing other aspects of faces.
C1 [Walsh, Jennifer A.; Vida, Mark D.; Rutherford, M. D.] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada.
RP Rutherford, MD (reprint author), McMaster Univ, Dept Psychol Neurosci & Behav, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.
EM rutherm@mcmaster.ca
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
Blalock H. M., 1972, SOCIAL STAT
Calder AJ, 2000, COGNITION, V76, P105, DOI 10.1016/S0010-0277(00)00074-3
CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218
Gross TF, 2004, J ABNORM CHILD PSYCH, V32, P469, DOI 10.1023/B:JACP.0000037777.17698.01
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
LOVELAND KA, 1995, DEV PSYCHOPATHOL, V7, P409
McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
OZONOFF S, 1990, J CHILD PSYCHOL PSYC, V31, P343, DOI 10.1111/j.1469-7610.1990.tb01574.x
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P187, DOI 10.1007/s10803-006-0151-9
Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
Tiddeman B, 2001, IEEE COMPUT GRAPH, V21, P42, DOI 10.1109/38.946630
Tiddeman BP, 2005, COMPUT GRAPH FORUM, V24, P449, DOI 10.1111/j.1467-8659.2005.00870.x
VOLKMAR FR, 1987, J AM ACAD CHILD PSY, V26, P156, DOI 10.1097/00004583-198703000-00005
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
NR 24
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1018
EP 1026
DI 10.1007/s10803-013-1953-1
PG 9
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200003
PM 24077783
ER
PT J
AU Duff, CK
Flattery, JJ
AF Duff, Christine K.
Flattery, J. J., Jr.
TI Developing Mirror Self Awareness in Students with Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Joint attention; Mirror self-awareness;
Pronoun development; Self permanence; Video modeling
ID JOINT ATTENTION; CHILDREN; RECOGNITION; AMYGDALA; 6-MONTH-OLDS;
EMERGENCE; LANGUAGE; GAZE
AB A teaching methodology and curriculum was designed to develop and increase positive self-awareness in students diagnosed with autism spectrum disorders (ASD). Joint attention (JA) strategies were first utilized to directly teach students about reflected mirror images, and then subsequently, to indirectly teach students about their reflected image. Not only were Mirror Self Awareness Development (MSAD) JA activities initiated and preferred by students over non MSAD JA activities, they yielded a four step framework with which to measure increases in student self-awareness. While the focus of this study was to increase positive self-awareness in students with ASD, it may contribute to understanding the developmental stages of 'Self'.
RP Duff, CK (reprint author), 291 Torpoint Gate, Longwood, FL 32779 USA.
EM mirrorselfawareness@yahoo.com
CR Asendorpf JB, 1996, DEV PSYCHOL, V32, P313, DOI 10.1037/0012-1649.32.2.313
Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
Cooley C., 1964, HUMAN NATURE SOCIAL
DAWSON G, 1984, J AUTISM DEV DISORD, V14, P383, DOI 10.1007/BF02409829
Delano ME, 2007, REM SPEC EDUC, V28, P33, DOI 10.1177/07419325070280010401
D'Entremont B, 1997, INFANT BEHAV DEV, V20, P569, DOI 10.1016/S0163-6383(97)90048-5
Diessel H, 2006, COGN LINGUIST, V17, P463, DOI 10.1515/COG.2006.015
Farroni T., 2002, GIORNALE ITALIANO PS, V29, P857
GALLUP GG, 1982, AM J PRIMATOL, V2, P237, DOI 10.1002/ajp.1350020302
GALLUP GG, 1970, SCIENCE, V167, P86, DOI 10.1126/science.167.3914.86
Hamann SB, 2002, PSYCHOL SCI, V13, P135, DOI 10.1111/1467-9280.00425
Harrington K., 2012, AUTISM ASPERGERS DIG
Huskinson L., 2004, NIETZCHE JUNG WHOLE
Joseph SM, 1997, J ANAL PSYCHOL, V42, P139
Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261
LEWIS M, 1989, CHILD DEV, V60, P146, DOI 10.1111/j.1467-8624.1989.tb02704.x
Mead George Herbert, 1962, MIND SELF SOC STANDP
Mizuno A, 2011, BRAIN, V134, P2422, DOI 10.1093/brain/awr151
Morales M, 1998, INFANT BEHAV DEV, V21, P373, DOI 10.1016/S0163-6383(98)90014-5
Mosconi MW, 2009, ARCH GEN PSYCHIAT, V66, P509, DOI 10.1001/archgenpsychiatry.2009.19
MUNDY P, 1994, DEV PSYCHOPATHOL, V6, P389, DOI 10.1017/S0954579400006003
Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
Murray DS, 2008, FOCUS AUTISM DEV DIS, V23, P5, DOI 10.1177/1088357607311443
Owens R. E., 2008, LANGUAGE DEV INTRO
Quinsay B., 2012, CSLOT CTR SPEECH LAN
Rochat P, 2003, CONSCIOUS COGN, V12, P717, DOI 10.1016/S1053-8100(03)00081-3
Rosenberg D., 2009, ARCH GEN PSYCHIAT, V66, P509, DOI [10.3410/f.1161963.622403.f1000.com/prime/1161963#eval622403, DOI 10.3410/F.1161963.622403.F1000.COM/PRIME/1161963#EVAL622403]
Rossetti L, 1990, ROSSETTI INFANT TODD
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
SPIKER D, 1984, CHILD DEV, V55, P214, DOI 10.1111/j.1467-8624.1984.tb00285.x
Volkmar F. R., 2005, HDB AUTISM PERVASIVE
Wehmeyer M., 2008, ED CHILDREN YOUTH AU, P433
Wicklund R. A., 1972, THEORY OBJECTIVE SEL
NR 34
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1027
EP 1038
DI 10.1007/s10803-013-1954-0
PG 12
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200004
PM 24077784
ER
PT J
AU Pallett, PM
Cohen, SJ
Dobkins, KR
AF Pallett, Pamela M.
Cohen, Shereen J.
Dobkins, Karen R.
TI Face and Object Discrimination in Autism, and Relationship to IQ and Age
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorders; Face processing; Object processing; Inversion
effects; Adolescents; Development
ID EMBEDDED FIGURES TASK; ASPERGER-SYNDROME; SPECTRUM DISORDERS; CONFIGURAL
INFORMATION; IDENTITY RECOGNITION; EXTRASTRIATE CORTEX;
SPATIAL-FREQUENCY; WILLIAMS-SYNDROME; INVERSION LEADS; FUNCTIONAL MRI
AB The current study tested fine discrimination of upright and inverted faces and objects in adolescents with Autism Spectrum Disorder (ASD) as compared to age- and IQ-matched controls. Discrimination sensitivity was tested using morphed faces and morphed objects, and all stimuli were equated in low-level visual characteristics (luminance, contrast, spatial frequency make-up). Participants with ASD exhibited slight, non-significant impairments in discrimination sensitivity for faces, yet significantly enhanced discrimination sensitivity for objects. The ASD group also showed a protracted development of face and object inversion effects. Finally, for ASD participants, face sensitivity improved with increasing IQ while object sensitivity improved with age. By contrast, for controls, face sensitivity improved with age, but neither face nor object sensitivity was influenced by IQ. These findings suggest that individuals with ASD follow a qualitatively different path in the development of face and object processing abilities.
C1 [Pallett, Pamela M.; Cohen, Shereen J.; Dobkins, Karen R.] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.
RP Dobkins, KR (reprint author), Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.
EM kdobkins@ucsd.edu
CR American Psychiatric Association, 2004, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P131, DOI 10.1007/s10803-005-0046-1
Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
Bookheimer SY, 2008, J INT NEUROPSYCH SOC, V14, P922, DOI 10.1017/S135561770808140X
Bosworth RG, 2006, J OPT SOC AM A, V23, P2085, DOI 10.1364/JOSAA.23.002085
BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Damarla SR, 2010, AUTISM RES, V3, P273, DOI 10.1002/aur.153
Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
Deruelle C, 2008, BRAIN COGNITION, V66, P115, DOI 10.1016/j.bandc.2007.06.001
Deruelle C, 2006, INT J PSYCHOL, V41, P97, DOI 10.1080/00207590500184610
Falck-Ytter T, 2008, AUTISM RES, V1, P297, DOI 10.1002/aur.45
Farah MJ, 1998, PSYCHOL REV, V105, P482, DOI 10.1037//0033-295X.105.3.482
Freire A, 2000, PERCEPTION, V29, P159, DOI 10.1068/p3012
Gauthier I, 2009, VISION RES, V49, P470, DOI 10.1016/j.visres.2008.12.007
Gepner B, 1996, CHILD NEUROPSYCHOL, V2, P123, DOI 10.1080/09297049608401357
Germine LT, 2011, COGNITION, V118, P201, DOI 10.1016/j.cognition.2010.11.002
Goffaux V, 2007, J EXP PSYCHOL HUMAN, V33, P995, DOI 10.1037/0096-1523.33.4.995
Goffaux V, 2011, CEREB CORTEX, V21, P467, DOI 10.1093/cercor/bhq112
Goffaux V, 2011, J VISION, V11, DOI 10.1167/11.10.1
Golarai G, 2006, CLIN NEUROSCI RES, V6, P145, DOI 10.1016/j.cnr.2006.08.001
Grill-Spector K, 1999, NEURON, V24, P187, DOI 10.1016/S0896-6273(00)80832-6
Grossman RB, 2008, RES AUTISM SPECT DIS, V2, P681, DOI 10.1016/j.rasd.2008.02.004
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Hauck M, 1998, CHILD NEUROPSYCHOL, V4, P187, DOI 10.1076/chin.4.3.187.3174
Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
Hole GJ, 1999, PERCEPTION, V28, P341, DOI 10.1068/p2622
Hubl D, 2003, NEUROLOGY, V61, P1232
Jarrold C, 2004, J AUTISM DEV DISORD, V34, P81, DOI 10.1023/B:JADD.0000018078.82542.ab
Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Kanwisher N, 1998, COGNITION, V68, pB1, DOI 10.1016/S0010-0277(98)00035-3
Kanwisher N, 1997, J NEUROSCI, V17, P4302
Lahaie A, 2006, NEUROPSYCHOLOGY, V20, P30, DOI 10.1037/0894-4105.20.1.30
Langner O, 2010, COGNITION EMOTION, V24, P1377, DOI 10.1080/02699930903485076
Leonard HC, 2011, J AUTISM DEV DISORD, V41, P968, DOI 10.1007/s10803-010-1115-7
Lopez B, 2004, VIS COGN, V11, P673, DOI 10.1080/13506280344000437
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Macchi Cassia V., 2009, DEVELOPMENTAL SCI, V12, P236, DOI [10.1111/j.1467-7687.2008.00765.x, DOI 10.1111/J.1467-7687.2008.00765.X]
Macchi Cassia V., 2011, J EXPT CHILD PSYCHOL, V109, P454, DOI [10.1016/j.jecp.2011.03.003, DOI 10.1016/J.JECP.2011.03.003]
Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4
McCleery JP, 2009, BIOL PSYCHIAT, V66, P950, DOI 10.1016/j.biopsych.2009.07.031
McKone E, 2009, PSYCHON B REV, V16, P778, DOI 10.3758/PBR.16.5.778
McKone E., 2009, COGNITIVE NEUROSCIEN, P467
McKone E, 2006, J EXP CHILD PSYCHOL, V94, P134, DOI 10.1016/j.jecp.2006.01.001
McKone E, 2007, TRENDS COGN SCI, V11, P8, DOI 10.1016/j.tics.2006.11.002
Morita T, 2012, SOC NEUROSCI-UK, V7, P223, DOI 10.1080/17470919.2011.598945
O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402
Pallett P. M., 2013, VISUAL NEUROSCI, P1, DOI [10.1017/S0952523813000217, DOI 10.1017/S0952523813000217]
Pallett PM, 2011, ATTEN PERCEPT PSYCHO, V73, P504, DOI 10.3758/s13414-010-0033-2
Pascalis O, 2011, WIRES COGN SCI, V2, P666, DOI 10.1002/wcs.146
Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366
Pellicano E, 2006, DEVELOPMENTAL SCI, V9, P270, DOI 10.1111/j.1467-7687.2006.00489.x
Picozzi M, 2009, J EXP CHILD PSYCHOL, V102, P487, DOI 10.1016/j.jecp.2008.11.001
Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
Pitcher D, 2009, CURR BIOL, V19, P319, DOI 10.1016/j.cub.2009.01.007
Riby DM, 2009, PSYCHOL REP, V105, P721, DOI 10.2466/PR0.105.3.721-726
Richler JJ, 2011, VISION RES, V51, P333, DOI 10.1016/j.visres.2010.11.014
Rinehart NJ, 2000, J CHILD PSYCHOL PSYC, V41, P769, DOI 10.1017/S002196309900596X
Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
ROLLS ET, 1992, PHILOS T ROY SOC B, V335, P11, DOI 10.1098/rstb.1992.0002
Rondan C, 2007, RES DEV DISABIL, V28, P197, DOI 10.1016/j.ridd.2006.02.007
Rose FE, 2007, J AUTISM DEV DISORD, V37, P513, DOI 10.1007/s10803-006-0200-4
Rosset DB, 2008, J AUTISM DEV DISORD, V38, P919, DOI 10.1007/s10803-007-0465-2
Rossion B, 2008, ACTA PSYCHOL, V128, P274, DOI 10.1016/j.actpsy.2008.02.003
Rutherford MD, 2007, VISION RES, V47, P2099, DOI 10.1016/j.visres.2007.01.029
Rutter M, 2003, NOVART FDN SYMP, V251, P1
Sangrigoli S, 2004, DEVELOPMENTAL SCI, V7, P74, DOI 10.1111/j.1467-7687.2004.00324.x
Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3
Scherf KS, 2012, DEV COGN NEUROS-NETH, V2, P199, DOI 10.1016/j.dcn.2011.07.016
Scherf KS, 2008, J CHILD PSYCHOL PSYC, V49, P838, DOI 10.1111/j.1469-7610.2008.01903.x
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Sekuler AB, 2004, CURR BIOL, V14, P391, DOI 10.1016/j.cub.2004.02.028
SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
TANAKA JW, 1993, Q J EXP PSYCHOL-A, V46, P225
Tanaka JW, 2007, PERCEPT PSYCHOPHYS, V69, P619, DOI 10.3758/BF03193919
TAYLOR MM, 1967, J ACOUST SOC AM, V41, P782, DOI 10.1121/1.1910407
Teunisse JP, 2003, BRAIN COGNITION, V52, P285, DOI 10.1016/S0278-2626(03)00042-3
VALENTINE T, 1988, BRIT J PSYCHOL, V79, P471
van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055
Vlamings PHJM, 2010, BIOL PSYCHIAT, V68, P1107, DOI 10.1016/j.biopsych.2010.06.024
Wechsler D., 1939, MEASUREMENT ADULT IN
Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
Wichmann FA, 2001, PERCEPT PSYCHOPHYS, V63, P1293, DOI 10.3758/BF03194544
Wilson CE, 2010, PERCEPTION, V39, P1645, DOI 10.1068/p6727
Wilson CE, 2010, J INTELL DISABIL RES, V54, P1104, DOI 10.1111/j.1365-2788.2010.01340.x
Wilson H. R., 2007, J AUTISM DEV DISORD, V37, P314
Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
Yamashita JA, 2005, J EXP PSYCHOL HUMAN, V31, P420, DOI 10.1037/0096-1523.31.3.420
YOUNG AW, 1987, PERCEPTION, V16, P747, DOI 10.1068/p160747
Zhao L, 2001, VISION RES, V41, P2979, DOI 10.1016/S0042-6989(01)00202-4
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 102
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1039
EP 1054
DI 10.1007/s10803-013-1955-z
PG 16
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200005
PM 24150884
ER
PT J
AU Koegel, LK
Park, MN
Koegel, RL
AF Koegel, Lynn Kern
Park, Mi N.
Koegel, Robert L.
TI Using Self-Management to Improve the Reciprocal Social Conversation of
Children with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Communication; Conversation; Self-management; Intervention
ID TEACHING-CHILDREN; QUESTION-ASKING; SCHOOL-STUDENTS; SKILLS;
INTERVENTIONS; SOCIALIZATION; COMMUNICATION; DISABILITIES; INDIVIDUALS;
SETTINGS
AB Individuals with autism spectrum disorders often exhibit difficulties with reciprocal social conversation, engaging in limited verbal exchanges, even when language structures are intact. This study employed a multiple baseline design to examine the effectiveness of a self-management intervention targeting (1) on-topic responsiveness to a conversational partner; (2) expansion of the conversational topic; and (3) on-topic question asking. Results demonstrated improved reciprocal social conversation through elaborated responses and on-topic question asking, which generalized and maintained. Social validity measures by naive observers indicated that the intervention led to meaningful improvements during conversation, including interest, naturalness, and desirability as a conversational partner.
C1 [Koegel, Lynn Kern] Univ Calif Santa Barbara, Koegel Autism Ctr, Santa Barbara, CA 93106 USA.
[Park, Mi N.] Univ Calif Santa Barbara, Gevirtz Grad Sch Educ, Counseling Clin & Sch Psychol Dept, Santa Barbara, CA 93106 USA.
[Koegel, Robert L.] Univ Calif Santa Barbara, Gevirtz Grad Sch Educ, Koegel Autism Ctr, Counseling Clin & Sch Psychol Dept, Santa Barbara, CA 93106 USA.
RP Koegel, RL (reprint author), Univ Calif Santa Barbara, Gevirtz Grad Sch Educ, Koegel Autism Ctr, Counseling Clin & Sch Psychol Dept, Santa Barbara, CA 93106 USA.
EM lynnk@education.ucsb.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baltaxe CA, 1977, J PEDIATR PSYCHOL, V2, P176, DOI DOI 10.1093/JPEPSY/2.4.176
Bang J, 2013, J AUTISM DEV DISORD, V43, P1732, DOI 10.1007/s10803-012-1716-4
Barlow D. H., 2008, SINGLE CASE EXPT DES
Boettcher M. A., 2004, THESIS U CALIFORNIA
Busk PL, 1992, SINGLE CASE RES DESI, P187
Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002
Charlop-Christy M.H., 2003, EDUC TREAT CHILD, V26, P108
Chin HY, 2000, J AUTISM DEV DISORD, V30, P569, DOI 10.1023/A:1005639427185
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
de Villiers J, 2007, J AUTISM DEV DISORD, V37, P1375, DOI 10.1007/s10803-006-0264-1
DiSalvo C., 2002, FOCUS AUTISM OTHER D, V17, P198, DOI DOI 10.1177/10883576020170040201
FINE J, 1994, J AUTISM DEV DISORD, V24, P315, DOI 10.1007/BF02172230
Hughes C, 2012, RES PRACT PERS SEV D, V37, P288
Jones CD, 2009, J AUTISM DEV DISORD, V39, P432, DOI 10.1007/s10803-008-0642-y
Kasari C, 2012, J CHILD PSYCHOL PSYC, V53, P431, DOI 10.1111/j.1469-7610.2011.02493.x
Koegel L. K., 1992, TEACH SELF MANAGEMEN
Koegel LK, 2012, J POSIT BEHAV INTERV, V14, P220, DOI 10.1177/1098300712437042
Koegel LK, 1998, AM J MENT RETARD, V102, P346
KOEGEL LK, 1992, J APPL BEHAV ANAL, V25, P341, DOI 10.1901/jaba.1992.25-341
Koegel R, 2013, J AUTISM DEV DISORD, V43, P2121, DOI 10.1007/s10803-013-1765-3
Koegel R. L., 2012, PRT POCKET GUIDE
KOEGEL RL, 1994, CURR I AUT, P81
LANDA R, 1992, PSYCHOL MED, V22, P245
Lee S. H., 2007, FOCUS AUTISM OTHER D, V22, P2, DOI DOI 10.1177/10883576070220010101
Locke J, 2013, SCH MENT HEALTH, V5, P38, DOI 10.1007/s12310-012-9092-y
McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
McDougall D, 1998, REM SPEC EDUC, V19, P310
Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
Newman B, 2000, BEHAV INTERVENT, V15, P145, DOI 10.1002/(SICI)1099-078X(200004/06)15:2<145::AID-BIN50>3.3.CO;2-V
Nuernberger JE, 2013, RES AUTISM SPECT DIS, V7, P411, DOI 10.1016/j.rasd.2012.09.004
Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
Palmen A, 2008, AUTISM, V12, P83, DOI 10.1177/1362361307085265
Paul R, 2008, CHILD ADOL PSYCH CL, V17, P835, DOI 10.1016/j.chc.2008.06.011
Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
Paul R, 2004, J AUTISM DEV DISORD, V34, P223, DOI 10.1023/B:JADD.0000022612.18116.46
Raghavendra P, 2013, CHILD CARE HLTH DEV, V39, P461, DOI 10.1111/cch.12084
Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
Sarokoff RA, 2001, J APPL BEHAV ANAL, V34, P81, DOI 10.1901/jaba.2001.34-81
Schriebman L., 1996, POSITIVE BEHAV SUPPO, P353
SCRUGGS TE, 1987, REM SPEC EDUC, V8, P24
STRAIN PS, 1994, J EMOT BEHAV DISORD, V2, P78
TAYLOR BA, 1995, J APPL BEHAV ANAL, V28, P3, DOI 10.1901/jaba.1995.28-3
Volkmar FR, 2011, DEV PSYCHOBIOL, V53, P428, DOI 10.1002/dev.20556
NR 44
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1055
EP 1063
DI 10.1007/s10803-013-1956-y
PG 9
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200006
PM 24127164
ER
PT J
AU van Steijn, DJ
Oerlemans, AM
van Aken, MAG
Buitelaar, JK
Rommelse, NNJ
AF van Steijn, Daphne J.
Oerlemans, Anoek M.
van Aken, Marcel A. G.
Buitelaar, Jan K.
Rommelse, Nanda N. J.
TI The Reciprocal Relationship of ASD, ADHD, Depressive Symptoms and Stress
in Parents of Children with ASD and/or ADHD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Attention-deficit/hyperactivity disorder;
Parenting stress; Depressive symptoms; Parental symptoms; Child
pathology
ID AUTISM SPECTRUM DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
PERVASIVE DEVELOPMENTAL DISORDERS; BEHAVIOR PROBLEMS; INTELLECTUAL
DISABILITY; SYNDROME SPECIFICITY; PRESCHOOL-CHILDREN; FAMILY RESILIENCE;
MENTAL-HEALTH; QUOTIENT AQ
AB This study investigated the role of parental Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and depressive symptoms on parenting stress in 174 families with children with ASD and/or ADHD, using generalized linear models and structural equation models. Fathers and mothers reported more stress when parenting with their child with ASD and/or ADHD than when parenting with the unaffected sibling; they also experienced more stress than a norm population. Depressive symptoms were most pronounced in the parents of children with ASD and ASD? ADHD. Spouse correlations were found for ASD, depression, and parenting stress. Paternal ASD and maternal ADHD symptoms were related to increased parenting stress, and parental ADHD symptoms with depressive symptoms and parenting stress. The results highlight the increased burden of raising a child with ASD and/or ADHD and the reciprocal relationship this has with parents' ASD, ADHD, and depressive symptoms, and levels of stress.
C1 [van Steijn, Daphne J.; Oerlemans, Anoek M.; Buitelaar, Jan K.; Rommelse, Nanda N. J.] Karakter Child & Adolescent Psychiat Univ Ctr, NL-6525 GC Nijmegen, Netherlands.
[Oerlemans, Anoek M.; Rommelse, Nanda N. J.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
[van Aken, Marcel A. G.] Univ Utrecht, Dept Dev Psychol, Utrecht, Netherlands.
[Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
RP van Steijn, DJ (reprint author), Karakter Child & Adolescent Psychiat Univ Ctr, Reinier Postlaan 12, NL-6525 GC Nijmegen, Netherlands.
EM d.vansteijn@karakter.com
CR (APA) APA, 2000, DIAGN STAT MAN MENT
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Benjamini Y, 2010, J R STAT SOC B, V72, P405
BENTLER PM, 1990, PSYCHOL BULL, V107, P238, DOI 10.1037//0033-2909.107.2.238
Berg-Nielsen T. S., 2002, CLIN CHILD PSYCHOL P, V7, P529, DOI DOI 10.1177/1359104502007004006
Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
Boomsma DI, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010621
Boothby K., 2010, TURKISH J PSYCHIAT, V21, P49
Cartwright KL, 2011, J AM ACAD CHILD PSY, V50, P1042, DOI 10.1016/j.jaac.2011.07.006
Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
Cherkasova M. V., 2012, MINERVA PSYCHIAT, V53, P11
Conners C. K., 1999, CONNERS ADULT ADHD R
Conners C. K., 1997, CONNERS RATING SCALE
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Craig L, 2006, GENDER SOC, V20, P259, DOI 10.1177/0891243205285212
De Brock A. A. J. L, 1992, NOSIK
Dix T, 2009, DEV REV, V29, P45, DOI 10.1016/j.dr.2008.11.002
Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
Faraone SV, 2009, PSYCHOL MED, V39, P685, DOI 10.1017/S0033291708003917
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Gupta VB, 2007, J DEV PHYS DISABIL, V19, P417, DOI 10.1007/s10882-007-9060-x
Harpin VA, 2005, ARCH DIS CHILD, V90, pI2, DOI 10.1136/adc.2004.059006
Hartman C. A., 2007, CHILDRENS SOCIAL BEH
Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
Head LS, 2007, MENT RETARD DEV D R, V13, P293, DOI 10.1002/mrdd.20169
Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Horwitz E, 2005, TIJDSCHR PSYCHIAT, V47, P291
Hu L., 1998, PSYCHOL METHODS, V4, P3
Kooij S. J. J., 2004, PSYCHOL MED, V35, P817
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Lee P. C., 2012, RES DEV DISABIL, V34, P656
Leigh B., 2008, BMC PSYCHIATRY, V8, P1
Little L., 2002, PEDIAT NURSING, V28, P265
Luteijn E., 2002, VRAGENLIJST INVENTAR
Muthen L. K., 1998, MPLUS USERS GUIDE, P197
Nezu A. M., 2006, PROBLEM SOLVING PROM
Ormel J., 1991, GEN HLTH QUESTIONNAI
Ornstein-Davis N., 2008, J AUTISM DEV DISORD, V38, P1278
Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
Ozdemir H, 2007, TURK PSIKIYATR DERG, V18, P13
Roach MA, 1999, AM J MENT RETARD, V104, P422, DOI 10.1352/0895-8017(1999)104<0422:MAFOCW>2.0.CO;2
Rommelse NNJ, 2007, J AM ACAD CHILD PSY, V46, P582, DOI 10.1097/chi.0b013e3180335af7
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Rutter M., 2003, SOCIAL COMMUNICATION
Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
Sterling L, 2008, J AUTISM DEV DISORD, V38, P1011, DOI 10.1007/s10803-007-0477-y
Taylor E, 1991, EPIDEMIOLOGY CHILDHO
Theule J., 2010, J EMOT BEHAV DISORD, V20, P640
Tomeny T. S., 2012, AUTISM
van IJzendoorn M. H., 2007, J ABNORMAL CHILD PSY, V35, P859
van Steijn DJ, 2012, J CHILD PSYCHOL PSYC, V53, P954, DOI 10.1111/j.1469-7610.2012.02556.x
Walsh F, 2002, FAM RELAT, V51, P130, DOI 10.1111/j.1741-3729.2002.00130.x
Walsh F, 2003, FAM PROCESS, V42, P1, DOI 10.1111/j.1545-5300.2003.00001.x
Wheaton B., 1997, SOCIOL METHODOL, P84
NR 59
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1064
EP 1076
DI 10.1007/s10803-013-1958-9
PG 13
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200007
PM 24114582
ER
PT J
AU May, T
Cornish, K
Rinehart, N
AF May, Tamara
Cornish, Kim
Rinehart, Nicole
TI Does Gender Matter? A One Year Follow-up of Autistic, Attention and
Anxiety Symptoms in High-Functioning Children with Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Gender; Autism spectrum disorder; Attention; Anxiety; Girls
ID PERVASIVE DEVELOPMENTAL DISORDERS; SEX-DIFFERENCES; PSYCHOPATHOLOGY;
INDIVIDUALS; ADOLESCENCE; COMORBIDITY; CHILDHOOD; PEOPLE; SAMPLE
AB Gender differences in autism spectrum disorder (ASD) symptoms and associated problem behaviours over development may provide clues regarding why more males than females are diagnosed with ASD. Fifty-six high-functioning children with ASD, and 44 typically developing controls, half of the participants female, were assessed at baseline (aged 7-12 years) and one-year later, collecting measures of autism, attention and anxiety symptoms, school placement and support information. Findings indicated no gender differences in autistic symptoms. Males were more hyperactive and received more integration-aide support in mainstream schools, and females were more socially anxious. Overall, similar gender profiles were present across two time points. Lower hyperactivity levels in females might contribute to their under-identification. Implications are discussed using a biopsychosocial model of gender difference.
C1 [May, Tamara; Cornish, Kim; Rinehart, Nicole] Monash Univ, Sch Psychol & Psychiat, Melbourne, Vic 3800, Australia.
RP May, T (reprint author), Monash Univ, Sch Psychol & Psychiat, Wellington Rd, Melbourne, Vic 3800, Australia.
EM Tamara.May@monash.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Biederman J, 2000, AM J PSYCHIAT, V157, P816, DOI 10.1176/appi.ajp.157.5.816
Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y
Burd L, 2002, J CHILD NEUROL, V17, P681, DOI 10.1177/088307380201700906
Conners C. K., 2003, CONNERS
Constantino JN, 2002, SOCIAL RESPONSIVENES
Crick NR, 2003, DEV PSYCHOPATHOL, V15, P719, DOI 10.1017/S095457940300035X
EPSTEIN NB, 1983, J MARITAL FAM THER, V9, P171, DOI 10.1111/j.1752-0606.1983.tb01497.x
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
GILLBERG C, 1987, J AUTISM DEV DISORD, V17, P273, DOI 10.1007/BF01495061
Guttmann-Steinmetz S, 2009, J AUTISM DEV DISORD, V39, P976, DOI 10.1007/s10803-009-0706-7
Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Kopp S., 1992, EUROPEAN CHILD ADOLE, V1, P89
Leekam S, 2007, J CHILD PSYCHOL PSYC, V48, P1131, DOI 10.1111/j.1469-7610.2007.01778.x
Levy F, 2005, J AM ACAD CHILD PSY, V44, P368, DOI 10.1097/01.chi.0000153232.64968.cl
Mandy W, 2011, J AUTISM DEV DISORD, V42, P1304
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
May T, 2013, J AUTISM DEV DISORD, V43, P2147, DOI 10.1007/s10803-013-1766-2
May T., 2012, J ATTEN DISORD, V18, DOI [10.1177/1087054712455502, DOI 10.1177/1087054712455502]
MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216
Migliore A, 2012, REHABIL COUNS BULL, V55, P176, DOI 10.1177/0034355212438943
Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
Rivet TT, 2011, J DEV PHYS DISABIL, V23, P399, DOI 10.1007/s10882-011-9235-3
Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Skuse DH, 2005, HUM MOL GENET, V14, pR27, DOI 10.1093/hmg/ddi112
Solomon M, 2012, J AUTISM DEV DISORD, V42, P48, DOI 10.1007/s10803-011-1215-z
Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
Thompson T., 2003, J LEARNING DISABILIT, V7, P345, DOI DOI 10.1177/1469004703074003
Wechsler D, 2005, WISC 4 AUSTR ADM SCO
Wechsler D, 1999, WECHSLER ABBREVIATED
Wehmeyer M. L., 2001, ED TREATMENT CHILDRE, V24, P28
White SW, 2007, J AUTISM DEV DISORD, V37, P1403, DOI 10.1007/s10803-006-0281-0
WING L, 1981, PSYCHIAT RES, V5, P129, DOI 10.1016/0165-1781(81)90043-3
Yianni-Coudurier C, 2008, J INTELL DISABIL RES, V52, P855, DOI 10.1111/j.1365-2788.2008.01100.x
Zwaigenbaum L, 2012, J AUTISM DEV DISORD, V42, P2585, DOI 10.1007/s10803-012-1515-y
NR 41
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1077
EP 1086
DI 10.1007/s10803-013-1964-y
PG 10
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200008
PM 24105364
ER
PT J
AU Nayfack, AM
Huffman, LC
Feldman, HM
Chan, J
Saynina, O
Wise, PH
AF Nayfack, Aaron M.
Huffman, Lynne C.
Feldman, Heidi M.
Chan, Jia
Saynina, Olga
Wise, Paul H.
TI Hospitalizations of Children with Autism Increased from 1999 to 2009
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Mental health; Hospitalization; Adolescence
ID HEALTH-CARE EXPENDITURES; SPECTRUM DISORDERS;
PSYCHIATRIC-HOSPITALIZATION; MEDICAID; COSTS
AB We performed a retrospective analysis of hospital discharges for children with autism, in comparison to children with cerebral palsy, Down syndrome, mental retardation/intellectual disability, and the general population. Hospitalizations for autism increased nearly threefold over 10 years, especially at the oldest ages, while hospitalizations for the other groups did not change. Leading discharge diagnoses for each age group in children with autism included mental health and nervous system disorders. Older age, Caucasian ethnicity, and living in a region with a high number of pediatric beds predicted hospitalizations associated with mental health diagnoses. These findings underscore the need for comprehensive clinical services that address the complex needs of children with autism to prevent costly hospitalizations.
C1 [Nayfack, Aaron M.; Huffman, Lynne C.; Feldman, Heidi M.; Chan, Jia; Saynina, Olga; Wise, Paul H.] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA.
[Nayfack, Aaron M.] Santa Clara Valley Med Ctr, Dept Pediat, San Jose, CA 95128 USA.
[Huffman, Lynne C.; Feldman, Heidi M.; Chan, Jia; Saynina, Olga; Wise, Paul H.] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA.
RP Nayfack, AM (reprint author), 828 S Bascom Ave,Suite 100, San Jose, CA 95128 USA.
EM aaron.nayfack@hhs.sccgov.org
CR Amendah D., 2011, AUTISM SPECTRUM DISO, P1347
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Centet on budget and policy priorities, 2007, COMP PUBLIC PRIVATE
Chamber J., 2004, WHAT ARE WE SPENDING
Chamberlain LJ, 2010, PEDIATRICS, V125, P1190, DOI 10.1542/peds.2009-1109
Cidav Z, 2013, J AUTISM DEV DISORD, V43, P924, DOI 10.1007/s10803-012-1637-2
Croen LA, 2006, PEDIATRICS, V118, pE1203, DOI 10.1542/peds.2006-0127
Department of Health Care Services, 2010, SPEC CAR CTR DIR
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Government Accountability Office, 2005, REP CHAIRM RANK MIN
Health Care Financing Administration, 2002, DRGS DIAGN REL GROUP
Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246
Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
Lokhandwala T, 2012, J AUTISM DEV DISORD, V42, P95, DOI 10.1007/s10803-011-1217-x
Mandell DS, 2008, J AUTISM DEV DISORD, V38, P1059, DOI 10.1007/s10803-007-0481-2
Mandell DS, 2006, J AUTISM DEV DISORD, V36, P475, DOI 10.1007/s10803-006-0088-z
Mandell DS, 2012, ARCH PEDIAT ADOL MED, V166, P68, DOI 10.1001/archpediatrics.2011.714
Peacock G, 2012, J DEV BEHAV PEDIATR, V33, P2, DOI 10.1097/DBP.0b013e31823969de
Peng CZ, 2009, J CHILD NEUROL, V24, P140, DOI 10.1177/0883073808321059
Pineda N, 2011, ARTHRIT CARE RES, V63, P998, DOI 10.1002/acr.20458
Pineda N., J PEDIAT HE IN PRESS
Shimabukuro TT, 2008, J AUTISM DEV DISORD, V38, P546, DOI 10.1007/s10803-007-0424-y
Wang L, 2010, J AM ACAD CHILD PSY, V49, P1165, DOI 10.1016/j.jaac.2010.08.003
NR 24
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1087
EP 1094
DI 10.1007/s10803-013-1965-x
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200009
PM 24122446
ER
PT J
AU Dammeyer, J
AF Dammeyer, Jesper
TI Symptoms of Autism Among Children with Congenital Deafblindness
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Blind; Deaf; Deafblindness; Differential diagnostics; Dual
sensory impairment
ID PERVASIVE DEVELOPMENTAL DISORDERS; INTELLECTUAL DISABILITY; BEHAVIOR
CHECKLIST; SPECTRUM DISORDERS; INFANTILE-AUTISM; BLIND-CHILDREN;
DEAF-CHILDREN; PEOPLE; MIND; COOCCURRENCE
AB Associations between congenital deafness or blindness and autism have been found. The main consequences of congenital sensory impairment, being barriers for communication, language and social interaction development, may lead to symptoms of autism. To date only few studies have been reported concerning individuals with congenital deafblindness. This study examines symptoms of autism among 71 children with congenital deafblindness using the Autism Behavior Checklist. The cohort of children with congenital deafblindness was found to have symptoms of autism on a level similar to children with another developmental disorder than autism for example intellectual disability. No association was found between severity of congenital sensory impairment and severity or type of symptoms of autism.
C1 [Dammeyer, Jesper] Univ Copenhagen, Dept Psychol, DK-1353 Copenhagen K, Denmark.
[Dammeyer, Jesper] Ctr Deafblindness & Hearing Impairment, Aalborg, Denmark.
RP Dammeyer, J (reprint author), Univ Copenhagen, Dept Psychol, Oster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark.
EM jesper.dammeyer@psy.ku.dk
CR Andrews R., 2005, BRIT J VISUAL IMPAIR, V23, P52, DOI 10.1177/0264619605054776
Brown R, 1997, J CHILD PSYCHOL PSYC, V38, P693, DOI 10.1111/j.1469-7610.1997.tb01696.x
Carvill S, 2001, J INTELL DISABIL RES, V45, P467, DOI 10.1046/j.1365-2788.2001.00366.x
Cass H., 1998, AUTISM, V2, P117, DOI 10.1177/1362361398022002
Chess S., 1972, PSYCHIAT DISORDERS C
Dale N., 2005, AUTISM BLINDNESS RES, P74
Dammeyer J, 2010, INT J AUDIOL, V49, P76, DOI 10.3109/14992020903311388
Dammeyer J, 2011, RES DEV DISABIL, V32, P571, DOI 10.1016/j.ridd.2010.12.019
Dammeyer J., 2012, BRIT J VISUAL IMPAIR, V30, P101
Dammeyer J, 2009, J DEAF STUD DEAF EDU, V14, P278, DOI 10.1093/deafed/enn042
de Bildt A, 2005, J CHILD PSYCHOL PSYC, V46, P275, DOI 10.1111/j.1469-7610.2004.00346.x
Dekker R., 1991, J VISUAL IMPAIRMENT, V85, P123
Eaves RC, 2000, PSYCHOL SCHOOLS, V37, P311, DOI 10.1002/1520-6807(200007)37:4<323::AID-PITS2>3.0.CO;2-S
Fellinger J, 2012, LANCET, V379, P1037, DOI 10.1016/S0140-6736(11)61143-4
Fraiberg S., 1977, INSIGHTS BLIND, P248
Gense M. H., 2005, AUTISM SPECTRUM DISO
GORDON AG, 1991, AM J PSYCHIAT, V148, P1615
Hartshorne TS, 2005, AM J MED GENET A, V133A, P257, DOI 10.1002/ajmg.a.30545
Hobson R. P., 1997, BLINDNESS PSYCHOL DE, P99
Hobson RP, 2010, J CHILD PSYCHOL PSYC, V51, P1235, DOI 10.1111/j.1469-7610.2010.02274.x
Hobson RP, 2003, PHILOS T R SOC B, V358, P335, DOI 10.1098/rstb.2002.1201
Hoevenaars-van den Boom MAA, 2009, J INTELL DISABIL RES, V53, P548, DOI 10.1111/j.1365-2788.2009.01175.x
Janssen I., 2007, COMMUNICATION CONGEN
Johansson M, 2006, DEV MED CHILD NEUROL, V48, P40, DOI 10.1017/S0012162206000090
Jure R., 1991, DEV MED CHILD NEUROL, V33, P1060
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Krug DA, 1993, AUTISM SCREENING INS
Mayberry R. I., 2003, HDB NEUROPSYCHOLOG 2, V8, P487
Meristo M, 2007, DEV PSYCHOL, V43, P1156, DOI 10.1037/0012-1649.43.5.1156
Mukaddes NM, 2007, PSYCHIAT CLIN NEUROS, V61, P39, DOI 10.1111/j.1440-1819.2007.01608.x
Murdoch H., 2000, DBI REV MAGAZINE DEA, V26, P7
Peterson CC, 2005, CHILD DEV, V76, P502, DOI 10.1111/j.1467-8624.2005.00859.x
Peterson CC, 1999, PSYCHOL SCI, V10, P126, DOI 10.1111/1467-9280.00119
Preisler G., 2005, SCANDINAVIAN J DISAB, V7, P41, DOI DOI 10.1080/15017410510032145
PREISLER GM, 1995, CHILD CARE HLTH DEV, V21, P79, DOI 10.1111/j.1365-2214.1995.tb00412.x
PREISLER GM, 1991, CHILD CARE HLTH DEV, V17, P65, DOI 10.1111/j.1365-2214.1991.tb00680.x
Rodbroe I., 2006, COMMUNICATION CONGEN, VI
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
ROGERS SJ, 1989, DEV MED CHILD NEUROL, V31, P598
Roid G. H., 1997, EXAMINERS MANUAL LEI
Ronnberg J, 2001, SCAND AUDIOL, V30, P67, DOI 10.1080/010503901300112176
Roper L, 2003, AUTISM, V7, P245, DOI 10.1177/1362361303007003002
Rosenhall U, 1999, J AUTISM DEV DISORD, V29, P349, DOI 10.1023/A:1023022709710
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Szymanski CA, 2012, J AUTISM DEV DISORD, V42, P2027, DOI 10.1007/s10803-012-1452-9
Van Dijk J., 1993, STRATEGIES DEAFBLIND
Warren D. H., 2003, HDB NEUROPSYCHOLOGY, V8, P439
Zafeiriou DI, 2007, BRAIN DEV-JPN, V29, P257, DOI 10.1016/j.braindev.2006.09.003
NR 48
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1095
EP 1102
DI 10.1007/s10803-013-1967-8
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200010
PM 24127166
ER
PT J
AU Kaat, AJ
Lecavalier, L
Aman, MG
AF Kaat, Aaron J.
Lecavalier, Luc
Aman, Michael G.
TI Validity of the Aberrant Behavior Checklist in Children with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Aberrant Behavior Checklist; Factor analysis;
Irritability; Rating scales; Assessment
ID PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE;
FRAGILE-X-SYNDROME; MENTAL-RETARDATION; ADOLESCENTS; ARIPIPRAZOLE;
IRRITABILITY; RISPERIDONE; COMMUNITY; SAMPLE
AB The Aberrant Behavior Checklist (ABC) is a widely used measure in autism spectrum disorder (ASD) treatment studies. We conducted confirmatory and exploratory factor analyses of the ABC in 1,893 children evaluated as part of the Autism Treatment Network. The root mean square error of approximation was .086 for the standard item assignment, and in exploratory factor analysis, the large majority of items continued to load on the originally assigned factors. Correlations between the ABC subscales and multiple external variables including the Child Behavior Checklist and demographic variables supported the convergent and divergent validity of the ABC as a measure of behavior problems in ASD. Finally, we examined the impact of participant characteristics on subscale scores and present normative data.
C1 [Kaat, Aaron J.; Lecavalier, Luc; Aman, Michael G.] Ohio State Univ, Dept Psychol, Nisonger Ctr, Columbus, OH 43210 USA.
RP Aman, MG (reprint author), Ohio State Univ, Dept Psychol, Nisonger Ctr, 1581 Dodd Dr Room 175C, Columbus, OH 43210 USA.
EM aman.1@osu.edu
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Aman M., 1986, ABERRANT BEHAV CHECK
Aman MG, 2009, J AM ACAD CHILD PSY, V48, P1143, DOI 10.1097/CHI.0b013e3181bfd669
AMAN MG, 1985, AM J MENT DEF, V89, P485
Aman M.G., 2012, ANNOTATED BIBL UNPUB
AMAN MG, 1984, J CLIN CHILD PSYCHOL, V13, P237, DOI 10.1207/s15374424jccp1303_4
Aman MG, 2012, CLIN EXP PHARMACOL P, V2, pe114, DOI [DOI 10.4172/2161-1459.1000E114, 10.4172/2161-1459.1000e114]
Aman MG, 2004, CNS SPECTRUMS, V9, P36
Anderson DK, 2011, AJIDD-AM J INTELLECT, V116, P381, DOI 10.1352/1944-7558-116.5.381
Brinkley J, 2007, J AUTISM DEV DISORD, V37, P1949, DOI 10.1007/s10803-006-0327-3
Brown EC, 2002, RES DEV DISABIL, V23, P45, DOI 10.1016/S0891-4222(01)00091-9
Browne M. W., 2008, CEFA COMPREHENSIVE E
BROWNE MW, 1992, SOCIOL METHOD RES, V21, P230, DOI 10.1177/0049124192021002005
Budimirovic DB, 2011, DEV NEUROSCI-BASEL, V33, P379, DOI 10.1159/000330213
Card NA, 2008, CHILD DEV, V79, P1185, DOI 10.1111/j.1467-8624.2008.01184.x
COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
Einfeld SL, 2010, J MENT HEALTH RES IN, V3, P177, DOI 10.1080/19315864.2010.519098
FREUND LS, 1991, RES DEV DISABIL, V12, P435, DOI 10.1016/0891-4222(91)90037-S
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
Joreskog K., 2007, LISREL 8 8 WINDOWS C
Karabekiroglu K, 2009, CHILD PSYCHIAT HUM D, V40, P99, DOI 10.1007/s10578-008-0108-7
Lecavalier L, 2006, AM J MENT RETARD, V111, P199, DOI 10.1352/0895-8017(2006)111[199:VOTADI]2.0.CO;2
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
MARSHBURN EC, 1992, J AUTISM DEV DISORD, V22, P357, DOI 10.1007/BF01048240
Norris M, 2010, J AUTISM DEV DISORD, V40, P8, DOI 10.1007/s10803-009-0816-2
Oliver C, 2008, BRIT J PSYCHIAT, V193, P466, DOI 10.1192/bjp.bp.107.044370
Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
Ramtekkar UP, 2010, J AM ACAD CHILD PSY, V49, P217, DOI 10.1016/j.jaac.2009.11.011
Mccracken JT, 2005, AM J PSYCHIAT, V162, P1361
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
Roid G. H., 2003, STANFORD BINET INTEL
Sansone SM, 2012, J AUTISM DEV DISORD, V42, P1377, DOI 10.1007/s10803-011-1370-2
Satorra A., 1994, LATENT VARIABLES ANA, P399
Scahill L., 2012, J AUTISM DEV DISORD, V43, P739
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
Walley RM, 2005, J INTELL DISABIL RES, V49, P613, DOI 10.1111/j.1365-2788.2005.00717.x
Worley JA, 2011, RES AUTISM SPECT DIS, V5, P1086, DOI 10.1016/j.rasd.2010.12.002
NR 44
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1103
EP 1116
DI 10.1007/s10803-013-1970-0
PG 14
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200011
PM 24165702
ER
PT J
AU Chaidez, V
Hansen, RL
Hertz-Picciotto, I
AF Chaidez, Virginia
Hansen, Robin L.
Hertz-Picciotto, Irva
TI Gastrointestinal Problems in Children with Autism, Developmental Delays
or Typical Development
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Gastrointestinal problems; Autism; Developmental delays; Maladaptive
behaviors
ID SPECTRUM DISORDERS; SYMPTOMS; ASSOCIATION; PREVALENCE; DISEASE; ASDS
AB To compare gastrointestinal (GI) problems among children with: (1) autism spectrum disorder (ASD), (2) developmental delay (DD) and (3) typical development (TD), GI symptom frequencies were obtained for 960 children from the CHildhood Autism Risks from Genetics and Environment (CHARGE) study. We also examined scores on five Aberrant Behavior Checklist (ABC) subscales comparing ASD children with high versus low frequency GI symptoms. Compared to TD children, those with ASD [aOR 7.92 (4.89-12.85)] and DD [aOR 4.55 (2.51-8.24)] were more likely to have at least one frequent GI symptom. Restricting to ASD children, those with frequent abdominal pain, gaseousness, diarrhea, constipation or pain on stooling scored worse on irritability, social withdrawal, stereotypy, and hyperactivity compared with children having no frequent GI symptoms. Frequent GI problems affect young children with ASD and DD more commonly than those with TD. Maladaptive behaviors correlate with GI problems, suggesting these comorbidities require attention.
C1 [Chaidez, Virginia] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95618 USA.
[Hansen, Robin L.] Univ Calif Davis, Sch Med, Dept Pediat, Davis, CA 95616 USA.
[Hansen, Robin L.; Hertz-Picciotto, Irva] Univ Calif Davis, Med Invest Neurodev Disorders MIND Inst, Davis, CA 95616 USA.
[Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Div Environm & Occupat Hlth, Davis, CA 95616 USA.
RP Chaidez, V (reprint author), Univ Calif Davis, UC CalFresh Nutr Educ Program, State Off, 1103 Meyer Hall, Davis, CA 95616 USA.
EM vachaidez@ucdavis.edu
CR Aman M., 1994, ABERRANT BEHAV CHECK
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D
de Theije CGM, 2011, EUR J PHARMACOL, V668, pS70, DOI 10.1016/j.ejphar.2011.07.013
Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
Herndon AC, 2009, J AUTISM DEV DISORD, V39, P212, DOI 10.1007/s10803-008-0606-2
Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
Jyonouchi H, 2005, J PEDIATR-US, V146, P605, DOI 10.1016/j.peds.2005.01.027
Lord C, 2003, AUTISM DIAGNOSTIC OB
Lord C, 1993, AUTISM DIAGNOSTIC IN
Maenner MJ, 2012, J AUTISM DEV DISORD, V42, P1520, DOI 10.1007/s10803-011-1379-6
Molloy CA, 2003, AUTISM, V7, P165, DOI 10.1177/1362361303007002004
Mullen E, 1995, MULLEN SCALES EARLY
Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8
Schieve LA, 2012, RES DEV DISABIL, V33, P467, DOI 10.1016/j.ridd.2011.10.008
Sparrow S, 1984, VINELAND ADAPTIVE BE
Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a
NR 19
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1117
EP 1127
DI 10.1007/s10803-013-1973-x
PG 11
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200012
PM 24193577
ER
PT J
AU Lecavalier, L
Wood, JJ
Halladay, AK
Jones, NE
Aman, MG
Cook, EH
Handen, BL
King, BH
Pearson, DA
Hallett, V
Sullivan, KA
Grondhuis, S
Bishop, SL
Horrigan, JP
Dawson, G
Scahill, L
AF Lecavalier, Luc
Wood, Jeffrey J.
Halladay, Alycia K.
Jones, Nancy E.
Aman, Michael G.
Cook, Edwin H.
Handen, Benjamin L.
King, Bryan H.
Pearson, Deborah A.
Hallett, Victoria
Sullivan, Katherine Anne
Grondhuis, Sabrina
Bishop, Somer L.
Horrigan, Joseph P.
Dawson, Geraldine
Scahill, Lawrence
TI Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Anxiety; Instrument; Measure; Assessment;
Treatment; Intervention
ID PERVASIVE DEVELOPMENTAL DISORDERS; COGNITIVE-BEHAVIORAL THERAPY;
DRUG-ADMINISTRATION PERSPECTIVE; MULTIPLE INFORMANT AGREEMENT; REVISED
CHILD ANXIETY; CONTROLLED-TRIAL; INTERVIEW SCHEDULE; RATING-SCALE;
DSM-IV; PSYCHOMETRIC PROPERTIES
AB Despite the high rate of anxiety in individuals with autism spectrum disorder (ASD), measuring anxiety in ASD is fraught with uncertainty. This is due, in part, to incomplete consensus on the manifestations of anxiety in this population. Autism Speaks assembled a panel of experts to conduct a systematic review of available measures for anxiety in youth with ASD. To complete the review, the panel held monthly conference calls and two face-to-face meetings over a fourteen-month period. Thirty eight published studies were reviewed and ten assessment measures were examined: four were deemed appropriate for use in clinical trials, although with conditions; three were judged to be potentially appropriate, while three were considered not useful for clinical trials assessing anxiety. Despite recent advances, additional relevant, reliable and valid outcome measures are needed to evaluate treatments for anxiety in ASD.
C1 [Lecavalier, Luc; Aman, Michael G.; Grondhuis, Sabrina] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[Lecavalier, Luc; Aman, Michael G.; Grondhuis, Sabrina] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
[Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Educ, Los Angeles, CA USA.
[Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA USA.
[Halladay, Alycia K.; Jones, Nancy E.; Horrigan, Joseph P.; Dawson, Geraldine] Autism Speaks, New York, NY USA.
[Jones, Nancy E.; Horrigan, Joseph P.] Neuren Pharmaceut Ltd, Durham, NC USA.
[Cook, Edwin H.] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA.
[Handen, Benjamin L.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
[King, Bryan H.] Univ Washington, Dept Psychiat, Seattle, WA 98195 USA.
[King, Bryan H.] Univ Washington, Dept Behav Sci, Seattle, WA 98195 USA.
[King, Bryan H.] Seattle Childrens Hosp, Seattle, WA USA.
[Pearson, Deborah A.] Univ Texas Med Sch, Dept Psychiat, Houston, TX USA.
[Pearson, Deborah A.] Univ Texas Med Sch, Dept Behav Sci, Houston, TX USA.
[Hallett, Victoria] Kings Coll London, London WC2R 2LS, England.
[Sullivan, Katherine Anne] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
[Bishop, Somer L.] Weill Cornell Med Coll, Dept Psychiat & Psychol, New York, NY USA.
[Dawson, Geraldine] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA.
[Scahill, Lawrence] Emory Univ, Dept Pediat, Marcus Ctr, Atlanta, GA 30329 USA.
RP Scahill, L (reprint author), Emory Univ, Dept Pediat, Marcus Ctr, 1920 Briarcliff Rd, Atlanta, GA 30329 USA.
EM lawrence.scahill@emory.edu
CR Achenbach TM, 2005, J CLIN CHILD ADOLESC, V34, P541, DOI 10.1207/s15374424jccp3403_9
Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Achenbach TM, 1991, MANUAL CHILD BEHAV C
AMAN MG, 1985, AM J MENT DEF, V89, P485
Aman MG, 1996, RES DEV DISABIL, V17, P41, DOI 10.1016/0891-4222(95)00039-9
Aman MG, 2002, AM J PSYCHIAT, V159, P1337, DOI 10.1176/appi.ajp.159.8.1337
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Barmish AJ, 2005, J CLIN CHILD ADOLESC, V34, P569, DOI 10.1207/s15374424jccp3403_12
Birmaher B, 1997, J AM ACAD CHILD PSY, V36, P545, DOI 10.1097/00004583-199704000-00018
Birmaher B, 1999, J AM ACAD CHILD PSY, V38, P1230, DOI 10.1097/00004583-199910000-00011
Cartwright-Hatton S., 2011, J AM ACAD CHILD ADOL, V50, p[242, e6]
Centers for Disease Control and Prevention, 2012, MORBIDITY MORTALITY, V61
Centre for Childhood Disability Research, 2004, OUTC MEAS RAT FORM G
Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
Chorpita BF, 2000, BEHAV RES THER, V38, P835, DOI 10.1016/S0005-7967(99)00130-8
Chorpita BF, 2008, J PSYCHOPATHOL BEHAV, V30, P52, DOI 10.1007/s10862-007-9075-8
Chorpita BF, 2005, BEHAV RES THER, V43, P309, DOI 10.1016/j.brat.2004.02.004
Costello EJ, 2005, CHILD ADOL PSYCH CL, V14, P631, DOI 10.1016/j.chc.2005.06.003
CURRY JF, 1990, J CONSULT CLIN PSYCH, V58, P109, DOI 10.1037//0022-006X.58.1.109
Dierker LC, 2001, J AM ACAD CHILD PSY, V40, P929, DOI 10.1097/00004583-200108000-00015
Diggle P, 2002, ANAL LONGITUDINAL DA, V2nd
Dutra L, 2004, J CLIN PSYCHOL, V60, P65, DOI 10.1002/jclp.10234
Ebesutani C, 2010, J PSYCHOPATHOL BEHAV, V32, P373, DOI 10.1007/s10862-009-9174-9
Esbensen AJ, 2003, J AUTISM DEV DISORD, V33, P617, DOI 10.1023/B:JADD.0000005999.27178.55
Evans DW, 2005, CHILD PSYCHIAT HUM D, V36, P3, DOI 10.1007/s10578-004-3619-x
Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
Fleiss JL, 2003, WILEY SERIES PROBABI, V3rd
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Gadow K. D., 2002, CHILD SYMPTON INVENT
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Ginsburg GS, 2011, CHILD YOUTH CARE FOR, V40, P93, DOI 10.1007/s10566-010-9125-3
Ginsburg GS, 2011, J CONSULT CLIN PSYCH, V79, P806, DOI 10.1037/a0025933
Gotham K., 2012, AUTISM RES, V6, P33
Grills AE, 2003, J AM ACAD CHILD PSY, V42, P30, DOI 10.1097/01.CHI.0000024899.60748.EE
Grondhuis SN, 2012, RES AUTISM SPECT DIS, V6, P1345, DOI 10.1016/j.rasd.2012.04.006
Hallett V, 2009, DEPRESS ANXIETY, V26, P316, DOI 10.1002/da.20539
Hallett V., 2013, J AUTISM DEV DISORDE
Hallett V, 2010, AM J PSYCHIAT, V167, P809, DOI 10.1176/appi.ajp.2009.09070990
Hallett V, 2013, J CHILD PSYCHOL PSYC, V54, P1176, DOI 10.1111/jcpp.12068
Kerns CM, 2012, CLIN PSYCHOL-SCI PR, V19, P323, DOI 10.1111/cpsp.12009
King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
Laughren T, 2006, SCHIZOPHRENIA BULL, V32, P220, DOI 10.1093/schbul/sbi039
Laughren TP, 2003, BIOL PSYCHIAT, V54, P195, DOI 10.1016/S0006-3223(03)00529-8
Lecavalier L, 2004, J AUTISM DEV DISORD, V34, P709, DOI 10.1007/s10803-004-5291-1
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
LeDoux J, 1998, BIOL PSYCHIAT, V44, P1229, DOI 10.1016/S0006-3223(98)00282-0
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
March JS, 1997, J AM ACAD CHILD PSY, V36, P554, DOI 10.1097/00004583-199704000-00019
Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
Nunnally J. C., 1994, PSYCHOMETRIC THEORY
PERRIN S, 1992, J ABNORM CHILD PSYCH, V20, P567, DOI 10.1007/BF00911241
Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
Reaven JA, 2009, FOCUS AUTISM DEV DIS, V24, P27, DOI 10.1177/1088357608327666
Renno P., J AUTISM DEV DISORDE
Research Unit on Pediatric Psychopharmacology Anxiety Study Group, 2002, J AM ACAD CHILD ADOL, V41, P1061, DOI DOI 10.1097/00004583-200209000-00006
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
REYNOLDS CR, 1978, J ABNORM CHILD PSYCH, V6, P271, DOI 10.1007/BF00919131
Walkup JT, 2001, NEW ENGL J MED, V344, P1279, DOI 10.1056/NEJM200104263441703
Silverman W. K., 1996, ANXIETY DISORDERS IN
Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Snyder R, 2002, J AM ACAD CHILD PSY, V41, P1026, DOI 10.1097/01.CHI.0000020270/43550.CC
Storch EA, 2013, J AM ACAD CHILD PSY, V52, P132, DOI 10.1016/j.jaac.2012.11.007
Storch EA, 2012, J AUTISM DEV DISORD, V42, P2374, DOI 10.1007/s10803-012-1489-9
Storch EA, 2012, J CHILD ADOL PSYCHOP, V22, P292, DOI 10.1089/cap.2011.0114
Su LY, 2008, J ANXIETY DISORD, V22, P612, DOI 10.1016/j.janxdis.2007.05.011
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Thayler N. S., 2010, CHILD PSYCHIAT HUMAN, V41, P501
van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
Walkup JT, 2008, NEW ENGL J MED, V359, P2753, DOI 10.1056/NEJMoa0804633
Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477
White SW, 2013, J AUTISM DEV DISORD, V43, P382, DOI 10.1007/s10803-012-1577-x
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
Wood JJ, 2009, CHILD PSYCHIAT HUM D, V40, P301, DOI 10.1007/s10578-009-0127-z
Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
NR 79
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1128
EP 1143
DI 10.1007/s10803-013-1974-9
PG 16
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200013
PM 24158679
ER
PT J
AU Miller, L
McGonigle-Chalmers, M
AF Miller, Louisa
McGonigle-Chalmers, Maggie
TI Exploring Perceptual Skills in Children with Autism Spectrum Disorders:
From Target Detection to Dynamic Perceptual Discrimination
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Attention switching; Perception; Target discrimination
ID HIGH-FUNCTIONING AUTISM; VISUAL-SEARCH; ATTENTION; DEFICIT; ADULTS;
IMPAIRMENT; TASK; DISSOCIATION; ADHD
AB Perceptual processing in autism is associated with both 'strengths' and 'weaknesses' but within a literature that varies widely in terms of the assessments used. We report data from 12 children with autism spectrum disorders (ASD) and 12 age and IQ matched neurotypical controls tested on a set of tasks using the same stimuli throughout but systematically changing in difficulty. These tasks ranged through simple detection of stimulus onset to pairwise size discrimination across two approaching targets. Children with ASD were slower than controls even in simple detection tasks, but this did not explain further group differences found in the size discrimination of approaching targets. The results are discussed in terms of impairments in speed of responding in ASD under certain conditions of visuomotor coupling, stimulus presentation and increased information processing demands.
C1 [Miller, Louisa; McGonigle-Chalmers, Maggie] Univ Edinburgh, Dept Psychol, Sch Philosophy Psychol & Language Sci, Edinburgh EH8 9JZ, Midlothian, Scotland.
RP Miller, L (reprint author), Univ Edinburgh, Dept Psychol, Sch Philosophy Psychol & Language Sci, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland.
EM s0452198@sms.ed.ac.uk
CR Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3
Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003
Borghi A. M., 2004, HUMAN MOVEMENT SCI, V28, P12
Bott L, 2006, Q J EXP PSYCHOL, V59, P1237, DOI 10.1080/02724980543000196
BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535
Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
Frith U., 2003, AUTISM EXPLAINING EN
Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006
Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
Goldstein G, 2008, NEUROPSYCHOLOGY, V22, P301, DOI 10.1037/0894-4105.22.3.301
Goldstein G, 2001, J AUTISM DEV DISORD, V31, P433, DOI 10.1023/A:1010620820786
Gonzalez C, 2013, J AUTISM DEV DISORD, V43, P2259, DOI 10.1007/s10803-013-1772-4
Greenaway R, 2005, PSYCHOL SCI, V16, P987, DOI 10.1111/j.1467-9280.2005.01648.x
Grissom RJ, 2012, EFFECT SIZES FOR RESEARCH: UNIVARIATE AND MULTIVARIATE APPLICATIONS, 2ND EDITION, P1
Grubb MA, 2013, AUTISM RES, V6, P108, DOI 10.1002/aur.1269
Happe F., 2010, AUTISM TALENT
Jarrold C, 2005, DEVELOPMENTAL SCI, V8, P344, DOI 10.1111/j.1467-7687.2005.00422.x
Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019
Joliffe T., 1997, J CHILD PSYCHOL PSYC, V38, P52
Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
Kaufman A. S., 2004, KAUFMAN ASSESSMENT B
Mann TA, 2003, J CHILD PSYCHOL PSYC, V44, P274, DOI 10.1111/1469-7610.00120
McGonigle-Chalmers M, 2008, J AUTISM DEV DISORD, V38, P1382, DOI 10.1007/s10803-007-0396-y
Minshew NJ, 1999, NEUROLOGY, V52, P917
Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795
O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P765, DOI 10.1017/S0021963098002601
Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149
Purcell C, 2012, DEVELOPMENTAL SCI, V15, P299, DOI 10.1111/j.1467-7687.2011.01123.x
Ronconi L, 2013, CORTEX, V49, P1025, DOI 10.1016/j.cortex.2012.03.005
Rosset DB, 2008, J AUTISM DEV DISORD, V38, P919, DOI 10.1007/s10803-007-0465-2
Sachse M, 2013, J AUTISM DEV DISORD, V43, P1222, DOI 10.1007/s10803-012-1668-8
Schmitz N, 2007, NEUROSCI LETT, V412, P12, DOI 10.1016/j.neulet.2006.07.077
Schomaker J., 2009, J EUROPEAN PSYCHOL S, V1, P1
SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
Sussman E., 2003, PSYCHONOMIC B REV, V10
Tsatsanis K. D., 2005, HDB AUTISM PERVASIVE, P365
Wainwright JA, 1996, J AUTISM DEV DISORD, V26, P423, DOI 10.1007/BF02172827
Walter E, 2009, J AUTISM DEV DISORD, V39, P339, DOI 10.1007/s10803-008-0630-2
NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1144
EP 1157
DI 10.1007/s10803-013-1977-6
PG 14
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200014
PM 24141747
ER
PT J
AU Wei, X
Christiano, ERA
Yu, JW
Blackorby, J
Shattuck, P
Newman, LA
AF Wei, Xin
Christiano, Elizabeth R. A.
Yu, Jennifer W.
Blackorby, Jose
Shattuck, Paul
Newman, Lynn A.
TI Postsecondary Pathways and Persistence for STEM Versus Non-STEM Majors:
Among College Students with an Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; 2-Year community colleges; 4-Year universities; College pathway;
College persistence; Science, technology, engineering and mathematics
(STEM)
ID PREVALENCE; CHILDREN
AB Little is known about postsecondary pathways and persistence among college students with an autism spectrum disorder (ASD). This study analyzed data from the National Longitudinal Transition Study-2, 2001-2009, a nationally representative sample of students in special education with an ASD who progressed from high school to postsecondary education. Findings suggest that most college students with an ASD enrolled in a 2-year community college at some point in the postsecondary careers (81 %). Those in science, technology, engineering and mathematics (STEM) fields were more likely to persist in a 2-year community college and were twice as likely to transfer from a 2-year community college to a 4-year university than their peers in the non-STEM fields. College persistence rates varied by gender, race, parent education level, and college pathway and major. Educational policy implications are discussed.
C1 [Wei, Xin; Christiano, Elizabeth R. A.; Yu, Jennifer W.; Blackorby, Jose; Newman, Lynn A.] SRI Int, Ctr Educ & Human Serv, Menlo Pk, CA 94025 USA.
[Shattuck, Paul] Drexel Univ, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA.
RP Wei, X (reprint author), SRI Int, Ctr Educ & Human Serv, 333 Ravenswood Ave,BS169, Menlo Pk, CA 94025 USA.
EM xin.wei@sri.com
CR Anderson D., 2006, INCREASING THE SUCCE
Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
Baron-Cohen S, 2007, HUM NATURE-INT BIOS, V18, P125, DOI 10.1007/s12110-007-9014-0
Baron-Cohen S, 2006, PROG NEURO-PSYCHOPH, V30, P865, DOI 10.1016/j.pnpbp.2006.01.010
Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
Centers for Disease Control and Prevention, 2013, NATIONAL HEALTH STAT, V65, P1
Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093
Chen X., 2012, NCES 2013 152
Choy S., 2001, STUDENTS WHOSE PAREN, V2001-126
Conger D, 2010, ANN AM ACAD POLIT SS, V627, P184, DOI 10.1177/0002716209348751
Fealing K. H., 2011, PAPER PRESENTED AT T
Fike D. S., 2008, COMMUNITY COLL REV, V36, DOI 10.1177/0091552108320222
Gandara P., 2012, BUILDING PATHWAYS TO
Glennon T. J., 2001, WORK, V17, P183
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Jefferson-Wilson P., 1999, THESIS
Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
Lee Jr J. M., 2011, THE COLLEGE COMPLETI
Malcom L. E., 2008, PRESENTED AT THE ASS
Nagle K., 2009, RESEARCH IN DISABILI
National Science Foundation, 2006, INVESTING IN AMERICA
Newman L., 2011, THE POST HIGH SCHOOL
Ponticelli JE, 2009, EXCEPTIONALITY, V17, P164, DOI 10.1080/09362830903028473
Roksa J., 2010, EQUAL OPPORTUNITY IN
Snyder TD, 2012, DIGEST OF EDUCATION
US Census Bureau, 2012, STATISTICAL ABSTRACT
Valdes K., NATIONAL LONGITUDINA
VanBergeijk E, 2008, J AUTISM DEV DISORD, V38, P1359, DOI 10.1007/s10803-007-0524-8
Wei X., 2012, J AUTISM DEV DISORD, V42, DOI [10.1007/s10803-012-1700-z, DOI 10.1007/S10803-012-1700-Z]
Weko T., 2009, STUDENTS WHO STUDY S
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 31
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1159
EP 1167
DI 10.1007/s10803-013-1978-5
PG 9
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200015
PM 24158680
ER
PT J
AU Cholemkery, H
Mojica, L
Rohrmann, S
Gensthaler, A
Freitag, CM
AF Cholemkery, Hannah
Mojica, Laura
Rohrmann, Sonja
Gensthaler, Angelika
Freitag, Christine M.
TI Can Autism Spectrum Disorders and Social Anxiety Disorders be
Differentiated by the Social Responsiveness Scale in Children and
Adolescents?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Psychometric assessment; Differential diagnosis; Child psychiatric
disorder; Autism spectrum disorder; Social anxiety disorders
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING AUTISM;
CROSS-CULTURAL VALIDATION; SELECTIVE MUTISM; ASPERGER-SYNDROME; TRAITS;
SYMPTOMS; FAMILY; MOOD; SRS
AB Autism spectrum disorder (ASD) as well as social phobia (SP), and selective mutism (SM) are characterised by impaired social interaction. We assessed the validity of the Social Responsiveness Scale (SRS) to differentiate between ASD, and SP/SM. Raw scores were compared in 6-18 year old individuals with ASD (N = 60), SP (N = 38), SM (N = 43), and typically developed (N = 42). Sensitivity and specificity were examined. The three disorders showed overlapping SRS scores. Especially in boys with SM (ROC-AUC = .81), presence of ASD was overestimated by the SRS. A combination of three disorder specific questionnaires resulted in marginally improved diagnostic accuracy. For the clinically very relevant differential diagnosis of SP/SM, SRS results must be interpreted with caution.
C1 [Cholemkery, Hannah; Mojica, Laura; Gensthaler, Angelika; Freitag, Christine M.] JW Goethe Univ Hosp, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
[Rohrmann, Sonja] Goethe Univ Frankfurt, Dept Psychol, D-60054 Frankfurt, Germany.
RP Cholemkery, H (reprint author), JW Goethe Univ Hosp, Dept Child & Adolescent Psychiat Psychosomat & Ps, Deutschordenstr 50, D-60528 Frankfurt, Germany.
EM Hannah.Cholemkery@kgu.de; L.Mojica@stud.uni-heidelberg.de;
Rohrmann@psych.uni-frankfurt.de; Angelika.Gensthaler@kgu.de;
C.Freitag@em.uni-frankfurt.de
CR Achenbach T. M., 1998, KOLN ARBEITSGRUPPE K
Adornetto Carmen, 2012, Child Adolesc Psychiatry Ment Health, V6, P40, DOI 10.1186/1753-2000-6-40
Aldridge FJ, 2012, J AUTISM DEV DISORD, V42, P294, DOI 10.1007/s10803-011-1242-9
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Andersson CB, 1998, NORD J PSYCHIAT, V52, P231, DOI 10.1080/08039489850139157
Aster M, 2006, WECHSLER INTELLIGENZ
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Bergman RL, 2002, J AM ACAD CHILD PSY, V41, P938, DOI 10.1097/00004583-200208000-00012
BLACK B, 1995, J AM ACAD CHILD PSY, V34, P847, DOI 10.1097/00004583-199507000-00007
BLACK B, 1992, J AM ACAD CHILD PSY, V31, P1090, DOI 10.1097/00004583-199211000-00015
Bolte S., 2008, SKALA ERFASSUNG SOZI
Bolte S, 2008, AUTISM RES, V1, P354, DOI 10.1002/aur.49
Bolte S, 2006, DIAGNOSTISCHES INTER
Bolte S., 2006, DTSCH FASSUNG SOCIAL
Bolte S., 2011, J AUTISM DEV DISORD, V42, P66
Carbone D, 2010, J ABNORM CHILD PSYCH, V38, P1057, DOI 10.1007/s10802-010-9425-y
Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
Chavira DA, 2007, J AM ACAD CHILD PSY, V46, P1464, DOI 10.1097/chi.0b013e318149366a
Cholemkery H, 2014, EUR CHILD ADOLES PSY, V23, P81, DOI 10.1007/s00787-013-0427-5
Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
Constantino JN, 2005, SOCIAL RESPONSIVENES
DeLong R, 2004, J NEUROPSYCH CLIN N, V16, P199, DOI 10.1176/appi.neuropsych.16.2.199
Dopfner M., 1994, HDB ELTERNFRAGEBOGEN
Dopfner M., 2008, DISYPS 2 DIAGNOSTIK
Field A., 2009, DISCOVERING STAT USI
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Ghaziuddin M., 2002, FOCUS AUTISM OTHER D, V17, P138, DOI DOI 10.1177/10883576020170030301
Glascoe FP, 2005, MENT RETARD DEV D R, V11, P173, DOI 10.1002/mrdd.20068
GRZADZINSKI R, 2011, AUTISM, V41, P1178
Hartley SL, 2009, AUTISM, V13, P485, DOI 10.1177/1362361309335717
Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
Koyama T, 2006, J AUTISM DEV DISORD, V36, P373, DOI 10.1007/s10803-006-0075-4
Kristensen H, 2000, J AM ACAD CHILD PSY, V39, P249, DOI 10.1097/00004583-200002000-00026
Kuusikko S, 2008, J AUTISM DEV DISORD, V38, P1697, DOI 10.1007/s10803-008-0555-9
Mazzone L, 2012, ANN GEN PSYCHIATR, V11, DOI 10.1186/1744-859X-11-16
Melfsen S., 2009, LEHRBUCH VERHALTENST, V1, P555
Melfsen S., 2006, EUROPEAN CHILD ADOLE, V12, P11
Merikangas KR, 2003, ACTA PSYCHIAT SCAND, V108, P28, DOI 10.1034/j.1600-0447.108.s417.5.x
Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071
Petermann F., 2010, HAMBURG WECHSLER INT
Pine DS, 2008, J AM ACAD CHILD PSY, V47, P652, DOI 10.1097/CHI.0b013e31816bffa5
Piven J, 1999, AM J PSYCHIAT, V156, P557
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Ruhl D, 2004, DIAGNOSTISCHE BEOBAC
Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
Rutter M., 2003, SOCIAL COMMUNICATION
Schneider S, 2009, DIAGNOSTISCHES INTER
Settipani CA, 2012, J ANXIETY DISORD, V26, P459, DOI 10.1016/j.janxdis.2012.01.010
Sharp WG, 2007, J ANXIETY DISORD, V21, P568, DOI 10.1016/j.janxdis.2006.07.002
Simonoff E., 2008, J AM ACAD CHILD ADOL, V47, P568
Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Tabachnick B., 2007, USING MUTIVARIATE ST
Taylor M. J., 2012, PSYCHOL MED, V16, P1
Towbin KE, 2005, J CHILD ADOL PSYCHOP, V15, P452, DOI 10.1089/cap.2005.15.452
Tyson KE, 2012, J AUTISM DEV DISORD, V42, P1477, DOI 10.1007/s10803-011-1386-7
van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
van Steensel FJA, 2013, J AUTISM DEV DISORD, V43, P361, DOI 10.1007/s10803-012-1575-z
Wang J, 2012, J AUTISM DEV DISORD, V42, P2450, DOI 10.1007/s10803-012-1499-7
Weill R. H., 2006, CFT 20 R GRUNDINTELL
White SW, 2012, J AUTISM DEV DISORD, V42, P874, DOI 10.1007/s10803-011-1325-7
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
NR 65
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1168
EP 1182
DI 10.1007/s10803-013-1979-4
PG 15
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200016
PM 24682652
ER
PT J
AU Brezis, RS
Galili, T
Wong, T
Piggot, JI
AF Brezis, Rachel S.
Galili, Tal
Wong, Tiffany
Piggot, Judith I.
TI Impaired Social Processing in Autism and its Reflections in Memory: A
Deeper View of Encoding and Retrieval Processes
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social memory; Autism; Encoding; Retrieval; Levels of processing
ID ASPERGERS-SYNDROME; INDIVIDUALS; SELF; DISORDERS; COGNITION; CHILDREN;
ABILITY; RATINGS; ADULTS; WORDS
AB Previous studies of memory in autism spectrum conditions (ASC) have consistently shown that persons with ASC have reduced memories for social information, relative to a spared memory for non-social facts. The current study aims to reproduce these findings, while examining the possible causes leading to this difference. Participants' memory for trait-words was tested after they had viewed the words in three study contexts: visuo-motor, letter-detection, and social judgment. While participants with ASC showed a levels-of-processing effect, such that their memory for words viewed in the social judgment context was greater than their memory for words viewed in the letter-detection context, their memory for socially-processed words was reduced relative to comparison participants. This interaction effect could not be explained by a speed/accuracy trade-off, nor could it be explained solely by differences in encoding. These results suggest that social memory deficits in ASC arise from difficulties both in orienting towards and encoding social content, as well as retaining and retrieving it. Implications for theory and clinical practice are discussed.
C1 [Brezis, Rachel S.] Univ Chicago, Dept Comparat Human Dev, Chicago, IL 60637 USA.
[Brezis, Rachel S.] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
[Galili, Tal] Tel Aviv Univ, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel.
[Wong, Tiffany; Piggot, Judith I.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
RP Brezis, RS (reprint author), Univ Calif Los Angeles, Ctr Culture & Hlth, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza,Box 62,Room B7-435, Los Angeles, CA 90024 USA.
EM rsbrezis@ucla.edu
CR ANDERSON NH, 1968, J PERS SOC PSYCHOL, V9, P272, DOI 10.1037/h0025907
Baron-Cohen S., 1999, UNDERSTANDING OTHER
Ben Shalom D, 2003, CORTEX, V39, P1129
Blair RJR, 1996, J AUTISM DEV DISORD, V26, P571
Boucher J, 2012, AUTISM, V16, P603, DOI 10.1177/1362361311417738
Boucher J, 2008, MEMORY AUTISM THEORY
Bowler DM, 2004, J AUTISM DEV DISORD, V34, P533, DOI 10.1007/s10803-004-2548-7
Brezis R. S., MEMORY SELF IN PRESS
Constantino JN, 2005, SOCIAL RESPONSIVENES
Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
Danker JF, 2010, PSYCHOL BULL, V136, P87, DOI 10.1037/a0017937
Henderson HA, 2009, J CHILD PSYCHOL PSYC, V50, P853, DOI 10.1111/j.1469-7610.2008.02059.x
HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Kuperman V, 2012, BEHAV RES METHODS, V44, P978, DOI 10.3758/s13428-012-0210-4
Lind SE, 2010, AUTISM, V14, P430, DOI 10.1177/1362361309358700
Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
Lord C., 1999, AUTISM DIAGNOSTIC OB
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
Merriam-Webster, 2009, MERR WEBST WORDCENTR
Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
MORRIS CD, 1977, J VERB LEARN VERB BE, V16, P519, DOI 10.1016/S0022-5371(77)80016-9
Mottron L, 2001, J CHILD PSYCHOL PSYC, V42, P253, DOI 10.1017/S0021963001006722
Piggot J, 2004, J AM ACAD CHILD PSY, V43, P473, DOI 10.1097/01.chi.0000111363.94169.37
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Rutter M., 2003, SOCIAL COMMUNICATION
Sinzig J, 2008, EUR CHILD ADOLES PSY, V17, P63, DOI 10.1007/s00787-007-0637-9
Stanislaw H, 1999, BEHAV RES METH INS C, V31, P137, DOI 10.3758/BF03207704
Takeda T, 2007, PSYCHIAT CLIN NEUROS, V61, P407, DOI 10.1111/j.1440-1819.2007.01678.x
Toichi M, 2002, NEUROPSYCHOLOGIA, V40, P964, DOI 10.1016/S0028-3932(01)00163-4
Wechsler D, 1999, WECHSLER ABBREVIATED
Whitehouse AJO, 2007, AUTISM, V11, P241, DOI 10.1177/1362361307076860
NR 32
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1183
EP 1192
DI 10.1007/s10803-013-1980-y
PG 10
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200017
PM 24214241
ER
PT J
AU Grainger, C
Williams, DM
Lind, SE
AF Grainger, Catherine
Williams, David M.
Lind, Sophie E.
TI Online Action Monitoring and Memory for Self-Performed Actions in Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Action monitoring; Enactment effect; Source
memory; Self-referencing; Agency
ID ASPERGER-SYNDROME; AUTOBIOGRAPHICAL MEMORY; FUNCTIONING AUTISM;
CHILDRENS MEMORY; EPISODIC MEMORY; ADULTS; EVENTS; MIND; INDIVIDUALS;
RECOGNITION
AB This study explored whether individuals with autism spectrum disorder (ASD) experience difficulties with action monitoring. Two experimental tasks examined whether adults with ASD are able to monitor their own actions online, and whether they also show a typical enactment effects in memory (enhanced memory for actions they have performed compared to actions they have observed being performed). Individuals with ASD and comparison participants showed a similar pattern of performance on both tasks. In a task which required individuals to distinguish person-caused from computer-caused changes in phenomenology both groups found it easier to monitor their own actions compared to those of an experimenter. Both groups also showed typical enactment effects. Despite recent suggestions to the contrary, these results support suggestions that action monitoring is unimpaired in ASD.
C1 [Grainger, Catherine; Williams, David M.] Univ Kent, Sch Psychol, Keynes Coll, Canterbury CT2 7NP, Kent, England.
[Lind, Sophie E.] City Univ London, Dept Psychol, Autism Res Grp, London EC1R 0JD, England.
RP Grainger, C (reprint author), Univ Kent, Sch Psychol, Keynes Coll, Canterbury CT2 7NP, Kent, England.
EM cg341@kent.ac.uk; D.M.Williams@kent.ac.uk; Sophie.Lind.2@city.ac.uk3
CR American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
BAKERWARD L, 1990, COGNITIVE DEV, V5, P55, DOI 10.1016/0885-2014(90)90012-I
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2
Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
COLTHEART M, 1981, Q J EXP PSYCHOL-A, V33, P497
Crane L, 2012, J AUTISM DEV DISORD, V42, P2100, DOI 10.1007/s10803-012-1459-2
Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
d Health Organization, 1993, INTERNATIONAL CLASSI
David N, 2008, J AUTISM DEV DISORD, V38, P593, DOI 10.1007/s10803-007-0425-x
ENGELKAMP J, 1989, PSYCHOL RES-PSYCH FO, V51, P153, DOI 10.1007/BF00309142
Engelkamp J., 1998, MEMORY FOR ACTIONS
Farrant A, 1998, J AUTISM DEV DISORD, V28, P43, DOI 10.1023/A:1026010919219
FERRARI M, 1983, J AUTISM DEV DISORD, V13, P317, DOI 10.1007/BF01531569
FRITH CD, 1989, PSYCHOL MED, V19, P359
FRITH U, 1969, J CHILD PSYCHOL PSYC, V10, P153, DOI 10.1111/j.1469-7610.1969.tb02077.x
Hala S, 2005, J AUTISM DEV DISORD, V35, P75, DOI 10.1007/s10803-004-1036-4
Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
Hare DJ, 2007, RES DEV DISABIL, V28, P317, DOI 10.1016/j.ridd.2006.03.003
Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
Hill EL, 2002, INFANT CHILD DEV, V11, P159, DOI 10.1002/icd.303
Hobson R. P., 1990, DEV PSYCHOPATHOL, V2, P163, DOI 10.1017/S0954579400000687
HURLBURT RT, 1994, PSYCHOL MED, V24, P385
Kucera H., 1967, COMPUTATIONAL ANALYS
Lind S. E., NEUROPSYCHOLOGY
Lind SE, 2010, J ABNORM PSYCHOL, V119, P896, DOI 10.1037/a0020631
Lind SE, 2009, J AUTISM DEV DISORD, V39, P643, DOI 10.1007/s10803-008-0670-7
Lind SE, 2010, AUTISM, V14, P430, DOI 10.1177/1362361309358700
Lind SE, 2009, J AUTISM DEV DISORD, V39, P1231, DOI 10.1007/s10803-009-0735-2
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Maras K., 2012, JOURNAL OF AUTISM AN, V43, P1
Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
Millward C, 2000, J AUTISM DEV DISORD, V30, P15, DOI 10.1023/A:1005455926727
Russell J, 1999, Cogn Neuropsychiatry, V4, P303
Russell J, 2001, J CHILD PSYCHOL PSYC, V42, P317, DOI 10.1017/S0021963001006874
Russell J, 1998, J AUTISM DEV DISORD, V28, P177, DOI 10.1023/A:1026009203333
Russell J., 1996, AGENCY ITS ROLE IN M
Sebanz N, 2005, COGN NEUROPSYCHOL, V22, P433, DOI 10.1080/02643290442000121
SUMMERS JA, 1994, J AUTISM DEV DISORD, V24, P773, DOI 10.1007/BF02172285
Wechsler D, 1999, WECHSLER ABBREVIATED
Williams D, 2010, DEVELOPMENTAL SCI, V13, P307, DOI 10.1111/j.1467-7687.2009.00885.x
Williams D, 2010, AUTISM, V14, P474, DOI 10.1177/1362361310366314
Williams D, 2009, J AUTISM DEV DISORD, V39, P251, DOI 10.1007/s10803-008-0619-x
Williams DM, 2009, J AUTISM DEV DISORD, V39, P865, DOI 10.1007/s10803-009-0695-6
Wojcik DZ, 2011, MEMORY, V19, P549, DOI 10.1080/09658211.2011.590506
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
Yirmiya N, 1998, PSYCHOL BULL, V124, P283, DOI 10.1037/0033-2909.124.3.283
Zalla T., 2010, PLOS ONE, V5, P1
NR 50
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1193
EP 1206
DI 10.1007/s10803-013-1987-4
PG 14
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200018
PM 24193578
ER
PT J
AU Harrop, C
McConachie, H
Emsley, R
Leadbitter, K
Green, J
AF Harrop, Clare
McConachie, Helen
Emsley, Richard
Leadbitter, Kathy
Green, Jonathan
CA PACT Consortium
TI Restricted and Repetitive Behaviors in Autism Spectrum Disorders and
Typical Development: Cross-Sectional and Longitudinal Comparisons
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Repetitive behaviors; Measurement longitudinal
ID YOUNG-CHILDREN; DIAGNOSTIC INTERVIEW; COMMUNICATION DISORDERS;
ASPERGER-SYNDROME; FOLLOW-UP; INTERESTS; STEREOTYPIES; INFANTS; TIME;
PLAY
AB Restricted and repetitive behaviors (RRBs) are characteristic of autism spectrum disorders (ASD). However, compared to social and communicative impairments, less is known about their development, trajectory and etiology. This study explored RRBs in young children with ASD matched to typically developing (TD) children on non-verbal development. RRBs were coded from direct observation at three time points within 13 months of development. Children with ASD displayed higher frequency and greater diversity of RRBs at all time points, however RRBs were not unique to ASD and evident in the TD control group albeit at a reduced frequency. RRBs did not correlate with social and communicative impairments in the ASD group, suggesting dissociation between these domains.
C1 [Harrop, Clare] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
[McConachie, Helen] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Emsley, Richard] Univ Manchester, Inst Populat Hlth, Ctr Biostat, Manchester, Lancs, England.
[Leadbitter, Kathy; Green, Jonathan] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England.
RP Harrop, C (reprint author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Autism Res & Treatment, 760 Westwood Plaza, Los Angeles, CA 90024 USA.
EM charrop@mednet.ucla.edu
RI Byford, Sarah/D-1699-2010; Pickles, Andrew/A-9625-2011; Barrett,
Barbara/F-7606-2010
OI Byford, Sarah/0000-0001-7084-1495; Pickles, Andrew/0000-0003-1283-0346;
Barrett, Barbara/0000-0002-0270-6256
CR American Psychiatric Association, 2013, DIAGN STAT MAN 5 DSM
Arnott B, 2010, J DEV BEHAV PEDIATR, V31, P223, DOI 10.1097/DBP.0b013e3181d5a2ad
Barber AB, 2012, J AUTISM DEV DISORD, V42, P2006, DOI 10.1007/s10803-011-1434-3
Barrett S, 2004, AUTISM, V8, P61, DOI 10.1177/1362361304040640
Bodfish J.W., 1999, REPETITIVE BEHAV SCA
Bornstein MH, 1996, CHILD DEV, V67, P2910, DOI 10.1111/j.1467-8624.1996.tb01895.x
Bornstein MH, 1997, INFANT BEHAV DEV, V20, P197, DOI 10.1016/S0163-6383(97)90022-9
Boyd B. A., 2010, DIRECT OBSERVA UNPUB
Bruckner CT, 2007, AUTISM, V11, P161, DOI 10.1177/1362361307075709
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
Chawarska K, 2007, J AUTISM DEV DISORD, V37, P62, DOI 10.1007/s10803-006-0330-8
Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947
DeLoache JS, 2007, DEV PSYCHOL, V43, P1579, DOI 10.1037/0012-1649.43.6.1579
Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P57, DOI 10.1007/s10803-008-0599-x
Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Gardenier NC, 2004, RES DEV DISABIL, V25, P99, DOI 10.1016/j.ridd.2003.05.004
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
Honey E, 2007, J AUTISM DEV DISORD, V37, P1107, DOI 10.1007/s10803-006-0253-4
Honey E, 2008, J AUTISM DEV DISORD, V38, P1439, DOI 10.1007/s10803-006-0191-1
Hus V, 2007, BIOL PSYCHIAT, V61, P438, DOI 10.1016/j.biopsych.2006.08.044
Kanner L, 1943, NERV CHILD, V2, P217
Kim SH, 2010, AUTISM RES, V3, P162, DOI 10.1002/aur.142
Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x
Leekam S, 2007, J CHILD PSYCHOL PSYC, V48, P1131, DOI 10.1111/j.1469-7610.2007.01778.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2002, AUTISM DIAGNOSTIC OB
Mahone EM, 2004, J PEDIATR-US, V145, P391, DOI 10.1016/j.jpeds.2004.06.014
Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
McConachie H, 2005, J AUTISM DEV DISORD, V35, P167, DOI 10.1007/s10803-005-1995-0
Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
Militerni R, 2002, EUR CHILD ADOLES PSY, V11, P210, DOI 10.1007/s00787-002-0279-x
Mooney EL, 2009, J AUTISM DEV DISORD, V39, P765, DOI 10.1007/s10803-008-0680-5
Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018
Moss J, 2013, AUTISM, V17, P390, DOI 10.1177/1362361312442790
Mullen E, 1995, MULLEN SCALES EARLY
MUNDY P, 1994, DEV PSYCHOPATHOL, V6, P389, DOI 10.1017/S0954579400006003
NOLDUS LPJJ, 1991, BEHAV RES METH INSTR, V23, P415
Ozonoff S., 2008, AUTISM, V12, P557
Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6
Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x
Ronald A, 2005, DEVELOPMENTAL SCI, V8, P444, DOI 10.1111/j.1467-7687.2005.00433.x
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x
Tan A, 1997, MOVEMENT DISORD, V12, P47, DOI 10.1002/mds.870120109
THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X
THELEN E, 1981, DEV PSYCHOL, V17, P237, DOI 10.1037//0012-1649.17.3.237
Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
Walker DR, 2004, J AM ACAD CHILD PSY, V43, P172, DOI 10.1097/01.chi.0000101375.03068.db
Watt N, 2008, J AUTISM DEV DISORD, V38, P1518, DOI 10.1007/s10803-007-0532-8
Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
Wetherby AM, 2002, COMMUNICATION SYMBOL
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
Zimmerman I.L., 1992, PRESCHOOL LANGUAGE S
NR 58
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1207
EP 1219
DI 10.1007/s10803-013-1986-5
PG 13
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200019
PM 24234675
ER
PT J
AU Riby, DM
Hanley, M
Kirk, H
Clark, F
Little, K
Fleck, R
Janes, E
Kelso, L
O'Kane, F
Cole-Fletcher, R
Allday, MH
Hocking, D
Cornish, K
Rodgers, J
AF Riby, Deborah M.
Hanley, Mary
Kirk, Hannah
Clark, Fiona
Little, Katie
Fleck, Ruth
Janes, Emily
Kelso, Linzi
O'Kane, Fionnuala
Cole-Fletcher, Rachel
Allday, Marianne Hvistendahl
Hocking, Darren
Cornish, Kim
Rodgers, Jacqui
TI The Interplay Between Anxiety and Social Functioning in Williams
Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Williams syndrome; Social; Anxiety
ID ASPERGER-SYNDROME; AUTISM SPECTRUM; BEHAVIORAL-CHARACTERISTICS;
PSYCHOMETRIC PROPERTIES; CHILDRENS ANXIETY; CONTROLLED-TRIAL;
YOUNG-CHILDREN; MENTAL-HEALTH; DISORDERS; ADULTS
AB The developmental disorder Williams syndrome (WS) has been associated with an atypical social profile of hyper-sociability and heightened social sensitivity across the developmental spectrum. In addition, previous research suggests that both children and adults with WS have a predisposition towards anxiety. The current research aimed to explore the profiles of social behaviour and anxiety across a broad age range of individuals with the disorder (n = 59, ages 6-36 years). We used insights from parental reports on two frequently used measures, the Spence Children's Anxiety Scale (SCAS-P) and the Social Responsiveness Scale (SRS). Severity of anxiety was correlated with a greater degree of social dysfunction as measured by the SRS in this group. We split the group according to high or low anxiety as measured by the SCAS-P and explored the profile of social skills for the two groups. Individuals high and low in anxiety differed in their social abilities. The results emphasise the need to address anxiety issues in this disorder and to consider how components of anxiety might relate to other features of the disorder.
C1 [Riby, Deborah M.; Hanley, Mary] Univ Durham, Dept Psychol, Sci Labs, Durham DH1 3LE, England.
[Riby, Deborah M.; Kirk, Hannah; Hocking, Darren; Cornish, Kim] Monash Univ, Sch Psychol & Psychiat, Melbourne, Vic 3004, Australia.
[Hanley, Mary; Kelso, Linzi; O'Kane, Fionnuala] Queens Univ, Sch Psychol, Belfast, Antrim, North Ireland.
[Clark, Fiona; Little, Katie; Fleck, Ruth; Allday, Marianne Hvistendahl] Newcastle Univ, Sch Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Janes, Emily; Cole-Fletcher, Rachel; Rodgers, Jacqui] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Janes, Emily] Northumberland Tyne & Wear NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England.
RP Riby, DM (reprint author), Univ Durham, Dept Psychol, Sci Labs, South Rd, Durham DH1 3LE, England.
EM Deborah.Riby@durham.ac.uk
CR Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
Blomberg S, 2006, RES DEV DISABIL, V27, P668, DOI 10.1016/j.ridd.2005.09.002
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Davies M, 1998, BRIT J PSYCHIAT, V172, P273, DOI 10.1192/bjp.172.3.273
Dimitropoulos A, 2009, J MENT HEALTH RES IN, V2, P220, DOI 10.1080/19315860903052204
Dodd H. F., 2009, J AUTISM DEV DISORD, P1
Dodd HF, 2009, J MENT HEALTH RES IN, V2, P89, DOI 10.1080/19315860902725867
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Dykens EM, 2005, AM J MENT RETARD, V110, P346, DOI 10.1352/0895-8017(2005)110[346:MAAIWS]2.0.CO;2
Dykens EM, 2003, DEV NEUROPSYCHOL, V23, P291, DOI 10.1207/S15326942DN231&2_13
Gillott Alinda, 2007, J Intellect Disabil, V11, P359, DOI 10.1177/1744629507083585
Graham JM, 2005, AM J MED GENET A, V133A, P240, DOI 10.1002/ajmg.a.30543
Hurtig T, 2009, AUTISM, V13, P583, DOI 10.1177/1362361309335719
Janes E, 2014, J INTELL DISABIL RES, V58, P746, DOI 10.1111/jir.12086
Jawaid A, 2012, J INTELL DISABIL RES, V56, P335, DOI 10.1111/j.1365-2788.2011.01452.x
Jones W, 2000, J COGNITIVE NEUROSCI, V12, P30, DOI 10.1162/089892900561968
Klein-Tasman BP, 2007, CHILD NEUROPSYCHOL, V13, P444, DOI 10.1080/09297040601033680
Klein-Tasman BP, 2009, J DEV BEHAV PEDIATR, V30, P289, DOI 10.1097/DBP.0b013e3181ad1f9a
Klein-Tasman BP, 2011, J AUTISM DEV DISORD, V41, P341, DOI 10.1007/s10803-010-1060-5
Klin A., 2000, ASPERGER SYNDROME
Korenberg J. R., 2003, NATURE ENCY HUMAN GE, P757
Leyfer OT, 2006, AM J MED GENET B, V141B, P615, DOI 10.1002/ajmg.b.30344
Little K, 2013, RES DEV DISABIL, V34, P959, DOI 10.1016/j.ridd.2012.11.020
Martens MA, 2008, J CHILD PSYCHOL PSYC, V49, P576, DOI 10.1111/j.1469-7610.2008.01887.x
Mervis CB, 2003, DEV NEUROPSYCHOL, V23, P243, DOI 10.1207/S15326942DN231&2_11
Mervis CB, 2000, BRAIN COGNITION, V44, P604, DOI 10.1006/brcg.2000.1232
Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
Porter MA, 2009, CHILD NEUROPSYCHOL, V15, P359, DOI 10.1080/09297040802577881
Porter MA, 2005, DEV NEUROPSYCHOL, V27, P275, DOI 10.1207/s15326942dn2702_5
Raven J. C., 1990, RAVENS COLOURED PROG
Riby D. M., 2013, J INTELLECT IN PRESS
Riby D. M., 2013, J NEURODEVE IN PRESS
Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x
Searcy YM, 2004, AM J MENT RETARD, V109, P231, DOI 10.1352/0895-8017(2004)109<231:TRBAAI>2.0.CO;2
Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
Spence SH, 2003, J ANXIETY DISORD, V17, P605, DOI 10.1016/S0887-6185(02)00236-0
Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
Stinton C, 2012, RES DEV DISABIL, V33, P144, DOI 10.1016/j.ridd.2011.09.002
Stinton C, 2010, AJIDD-AM J INTELLECT, V115, P3, DOI 10.1352/1944-7558-115.1.3
Stromme P, 2002, J CHILD NEUROL, V17, P269, DOI 10.1177/088307380201700406
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Tantam D, 2003, CHILD ADOL PSYCH CL, V12, P143, DOI 10.1016/S1056-4993(02)00053-6
UDWIN O, 1987, J CHILD PSYCHOL PSYC, V28, P297, DOI 10.1111/j.1469-7610.1987.tb00212.x
van der Fluit F, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00197
van Steensel FJA, 2013, J AUTISM DEV DISORD, V43, P361, DOI 10.1007/s10803-012-1575-z
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
NR 47
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1220
EP 1229
DI 10.1007/s10803-013-1984-7
PG 10
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200020
PM 24197115
ER
PT J
AU Griffith, GM
Hastings, RP
Petalas, MA
AF Griffith, Gemma M.
Hastings, Richard P.
Petalas, Michael A.
TI Brief Report: Fathers' and Mothers' Ratings of Behavioral and Emotional
Problems in Siblings of Children with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ASD; Sibling; SDQ; Mother; Father; Behavior
ID MATERNAL MENTAL-HEALTH; INTELLECTUAL DISABILITY; DIFFICULTIES
QUESTIONNAIRE; ADJUSTMENT; PARENT; STRENGTHS; SYMPTOMS; PSYCHOPATHOLOGY;
PERCEPTIONS; PROGRAMS
AB Debate is ongoing about whether typically developing siblings of children with autism spectrum disorder (ASD) are at greater risk of behavioral or emotional problems than siblings of children without ASD. Most data on behavior is provided by mothers, and we do not know whether fathers' reports differ. The strengths and difficulties questionnaire (Goodman in J Child Psychol Psychiatry 38(5):581-586, 1997) was completed by 168 mothers and 130 fathers. Parents were more likely to rate siblings as having 'abnormal' behavior when compared to a normative population. We found moderate correlations between mother-father ratings. More research may be needed to understand any clinical benefits of gathering data about sibling adjustment from more than one parent in the family. Implications for clinical practice and future research are discussed.
C1 [Griffith, Gemma M.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
[Hastings, Richard P.] Univ Warwick, Ctr Educ Dev Appraisal & Res, Coventry CV4 7AL, W Midlands, England.
[Petalas, Michael A.] Plas Coch Independent Hosp, St Asaph LL17 0HU, Denbigh, Wales.
RP Griffith, GM (reprint author), Bangor Univ, Sch Psychol, Brigantia Bldg, Bangor LL57 2AS, Gwynedd, Wales.
EM g.m.griffith@bangor.ac.uk; R.Hastings@warwick.ac.uk;
mike.petalas@mentalhealthcare-uk.com
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19
Benson PR, 2008, RES AUTISM SPECT DIS, V2, P583, DOI 10.1016/j.rasd.2007.12.002
Cassano M, 2006, J CLIN CHILD ADOLESC, V35, P583, DOI 10.1207/s15374424jccp3504_10
Cebula KR, 2012, J AUTISM DEV DISORD, V42, P847, DOI 10.1007/s10803-011-1322-x
Cuskelly M, 2006, J INTELL DISABIL RES, V50, P917, DOI 10.1111/j.1365-2788.2006.00922.x
CUSKELLY M, 1992, J CHILD PSYCHOL PSYC, V33, P749, DOI 10.1111/j.1469-7610.1992.tb00910.x
Dave S, 2008, CHILD PSYCHIAT HUM D, V39, P399, DOI 10.1007/s10578-008-0097-6
Duhig AM, 2000, CLIN PSYCHOL-SCI PR, V7, P435, DOI 10.1093/clipsy/7.4.435
Dyson L., 2003, LEARNING DISABILITIE, V18, P1, DOI 10.1111/1540-5826.00053
Fisman S, 2000, CAN J PSYCHIAT, V45, P369
GOLD N, 1993, J AUTISM DEV DISORD, V23, P147, DOI 10.1007/BF01066424
Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Guite J, 2004, CHILD HEALTH CARE, V33, P77, DOI 10.1207/s15326888chc3301_5
Hastings RP, 2003, J AUTISM DEV DISORD, V33, P99, DOI 10.1023/A:1022290723442
Hastings RP, 2003, J AUTISM DEV DISORD, V33, P141, DOI 10.1023/A:1022983209004
Hay DF, 1999, J CHILD PSYCHOL PSYC, V40, P1249, DOI 10.1017/S0021963099004795
Luoma I, 2004, NORD J PSYCHIAT, V58, P205, DOI 10.1080/08039480410006241
Macks RJ, 2007, J AUTISM DEV DISORD, V37, P1060, DOI 10.1007/s10803-006-0249-0
Meltzer H, 2000, MENTAL HLTH CHILDREN
Neece CL, 2010, AJIDD-AM J INTELLECT, V115, P291, DOI 10.1352/1944-7558-115.4.291
Neely-Barnes SL, 2011, FAM RELAT, V60, P331, DOI 10.1111/j.1741-3729.2011.00652.x
Nielsen KM, 2012, J PEDIATR NURS, V27, P34, DOI 10.1016/j.pedn.2010.08.009
Petalas MA, 2009, AUTISM, V13, P471, DOI 10.1177/1362361309335721
Petalas MA, 2012, RES AUTISM SPECT DIS, V6, P546, DOI 10.1016/j.rasd.2011.07.015
PHARES V, 1992, AM PSYCHOL, V47, P656, DOI 10.1037/0003-066X.47.5.656
Phares V, 2005, J PEDIATR PSYCHOL, V30, P631, DOI 10.1093/jpepsy/jsi050
Ross P, 2006, J INTELLECT DEV DIS, V31, P77, DOI 10.1080/13668250600710864
Rossiter L., 2001, J CHILD FAM STUD, V10, P65, DOI DOI 10.1023/A:1016629500708
Rowe DC, 1997, J ABNORM CHILD PSYCH, V25, P265, DOI 10.1023/A:1025756201689
Seligman M., 2009, ORDINARY FAMILIES SP
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
Totsika V, 2011, J ABNORM CHILD PSYCH, V39, P1137, DOI 10.1007/s10802-011-9534-2
Treutler CM, 2003, J ABNORM CHILD PSYCH, V31, P13, DOI 10.1023/A:1021765114434
Trivette CM, 2010, TOP EARLY CHILD SPEC, V30, P3, DOI 10.1177/0271121410364250
Verte S, 2003, CHILD CARE HLTH DEV, V29, P193, DOI 10.1046/j.1365-2214.2003.00331.x
NR 36
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1230
EP 1235
DI 10.1007/s10803-013-1969-6
PG 6
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200021
PM 24141746
ER
PT J
AU Russell-Smith, SN
Comerford, BJE
Maybery, MT
Whitehouse, AJO
AF Russell-Smith, Suzanna N.
Comerford, Bronwynn J. E.
Maybery, Murray T.
Whitehouse, Andrew J. O.
TI Brief Report: Further Evidence for a Link Between Inner Speech
Limitations and Executive Function in High-Functioning Children with
Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorder; Executive function; Cognitive
flexibility; Inner speech; Wisconsin card sorting test; Articulatory
suppression
ID CARD SORTING TEST; PRIVATE SPEECH; PERFORMANCE; DYSFUNCTION; MEMORY;
TASKS
AB This study investigated the involvement of inner speech limitations in the executive dysfunction associated with autism spectrum disorders (ASDs). Seventeen children with ASD and 18 controls, statistically-matched in age and IQ, performed a computer-based card sorting test (CST) to assess cognitive flexibility under four conditions: baseline, with articulatory suppression, with a concurrent mouthing task, and while verbalizing their strategies aloud. Articulatory suppression adversely affected CST performance for the control group but not the ASD group. The results additionally showed that overtly verbalizing strategies did not benefit the ASD children as it did the typically developing children. The findings thus provide further evidence that ASD children do not use inner speech to the same extent, or with the same effectiveness, as typically developing children when performing executive tasks.
C1 [Russell-Smith, Suzanna N.; Comerford, Bronwynn J. E.; Maybery, Murray T.; Whitehouse, Andrew J. O.] Univ Western Australia, Sch Psychol, Neurocognit Dev Unit, Perth, WA 6009, Australia.
[Whitehouse, Andrew J. O.] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia.
RP Russell-Smith, SN (reprint author), Univ Western Australia, Sch Psychol, Neurocognit Dev Unit, 35 Stirling Highway, Perth, WA 6009, Australia.
EM suzanna.russell-smith@uwa.edu.au
RI Maybery, Murray/H-5390-2014
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Baddeley A, 2001, J EXP PSYCHOL GEN, V130, P641, DOI 10.1037//0096-3445.130.4.641
Baldo JV, 2005, BRAIN LANG, V92, P240, DOI 10.1016/j.bandl.2004.06.103
Biro S, 2001, DEV PSYCHOPATHOL, V13, P97, DOI 10.1017/S0954579401001079
BIVENS JA, 1990, MERRILL PALMER QUART, V36, P443
Chapman R., 2000, SYSTEMATIC ANAL LANG
Grinter EJ, 2010, J CHILD PSYCHOL PSYC, V51, P717, DOI 10.1111/j.1469-7610.2009.02203.x
Heaton RK, 1993, WISCONSIN CARD SORTI
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Holland L, 2010, BRIT J DEV PSYCHOL, V28, P369, DOI 10.1348/026151009X424088
HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2
Kaland N, 2008, J AUTISM DEV DISORD, V38, P1161, DOI 10.1007/s10803-007-0474-1
Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
Perry W, 2001, J INT NEUROPSYCH SOC, V7, P344, DOI 10.1017/S1355617701733085
Russell J, 1999, J AUTISM DEV DISORD, V29, P103, DOI 10.1023/A:1023084425406
Sayhoun C., 2009, J AUTISM DEV DISORD, V39, P1014
SNODGRASS JG, 1980, J EXP PSYCHOL-HUM L, V6, P174, DOI 10.1037/0278-7393.6.2.174
Velazquez JLP, 2009, INT J PSYCHOPHYSIOL, V73, P341, DOI 10.1016/j.ijpsycho.2009.05.009
Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8
Wechsler D., 2003, WECHSLER INTELLIGENC
Whitehouse AJO, 2006, J CHILD PSYCHOL PSYC, V47, P857, DOI 10.1111/j.1469-7610.2006.01624.x
Williams DM, 2012, DEV PSYCHOPATHOL, V24, P225, DOI 10.1017/S0954579411000794
Winsler A, 2003, CHILD DEV, V74, P659, DOI 10.1111/1467-8624.00561
Winsler A, 2007, J AUTISM DEV DISORD, V37, P1617, DOI 10.1007/s10803-006-0294-8
NR 25
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1236
EP 1243
DI 10.1007/s10803-013-1975-8
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200022
PM 24197114
ER
PT J
AU Schreibman, L
Stahmer, AC
AF Schreibman, Laura
Stahmer, Aubyn C.
TI A Randomized Trial Comparison of the Effects of Verbal and Pictorial
Naturalistic Communication Strategies on Spoken Language for Young
Children with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Behavioral intervention; Functional communication; Vocal
language intervention; Pictorial communication intervention;
Augmentative communication
ID INTERVENTIONS; SPECTRUM; SPEECH; PRESCHOOLERS; ACQUISITION; DISORDERS;
PARADIGM; BEHAVIOR; PARENTS
AB Presently there is no consensus on the specific behavioral treatment of choice for targeting language in young nonverbal children with autism. This randomized clinical trial compared the effectiveness of a verbally-based intervention, Pivotal Response Training (PRT) to a pictorially-based behavioral intervention, the Picture Exchange Communication System (PECS) on the acquisition of spoken language by young (2-4 years), nonverbal or minimally verbal (<= 9 words) children with autism. Thirty-nine children were randomly assigned to either the PRT or PECS condition. Participants received on average 247 h of intervention across 23 weeks. Dependent measures included overall communication, expressive vocabulary, pictorial communication and parent satisfaction. Children in both intervention groups demonstrated increases in spoken language skills, with no significant difference between the two conditions. Seventy-eight percent of all children exited the program with more than 10 functional words. Parents were very satisfied with both programs but indicated PECS was more difficult to implement.
C1 [Schreibman, Laura] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.
[Stahmer, Aubyn C.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Stahmer, Aubyn C.] Rady Childrens Hosp, San Diego, CA USA.
RP Schreibman, L (reprint author), Univ Calif San Diego, Dept Psychol, 9500 Gilman Dr MC 0109, La Jolla, CA 92093 USA.
EM lschreibman@ucsd.edu; astahmer@ucsd.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Fenson L., 2006, MACARTHUR BATES COMM
Frost L., 2002, PICTURE EXCHANGE COM, V2nd
Ganz J. B., 2007, RES AUTISM SPECT DIS, V2, P167
Gardner MF, 1990, EXPRESSIVE ONE WORD
Koegel R. L., 1989, TEACH PIVOTAL BEHAV
KOEGEL RL, 1987, J AUTISM DEV DISORD, V17, P187, DOI 10.1007/BF01495055
KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P141, DOI 10.1007/BF01058147
Koegel RL, 1998, J AUTISM DEV DISORD, V28, P241, DOI 10.1023/A:1026073522897
LASKI KE, 1988, J APPL BEHAV ANAL, V21, P391, DOI 10.1901/jaba.1988.21-391
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mirenda P., 1988, FOCUS AUTISTIC BEHAV, V3, P1
Mullen E, 1995, MULLEN SCALES EARLY
National Research Council, 2001, ED CHILDR AUT
Romski M, 2010, J SPEECH LANG HEAR R, V53, P350, DOI 10.1044/1092-4388(2009/08-0156)
Sparrow SS, 1989, MAJOR PSYCHOL ASSESS, V2, P199
Sze K., 2003, ASS BEH AN
Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335
Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
NR 24
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1244
EP 1251
DI 10.1007/s10803-013-1972-y
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200023
PM 24272416
ER
PT J
AU McGonigle, JJ
Migyanka, JM
Glor-Scheib, SJ
Cramer, R
Fratangeli, JJ
Hegde, GG
Shang, J
Venkat, A
AF McGonigle, John J.
Migyanka, Joann M.
Glor-Scheib, Susan J.
Cramer, Ryan
Fratangeli, Jeffrey J.
Hegde, Gajanan G.
Shang, Jennifer
Venkat, Arvind
TI Development and Evaluation of Educational Materials for Pre-hospital and
Emergency Department Personnel on the Care of Patients with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Emergency medical services; Emergency nurse; Emergency department;
Autism spectrum disorder; Education
ID CHILDREN; HEALTH
AB With the rising prevalence of patients with autism spectrum disorder (ASD), there has been an increase in the acute presentation of these individuals to the general health care system. Emergency medical services and emergency department personnel commonly address the health care needs of patients with ASD at times of crisis. Unfortunately, there is little education provided to front-line emergency medical technicians, paramedics and emergency nurses on the characteristics of ASD and how these characteristics can create challenges for individuals with ASD and their health care providers in the pre-hospital and emergency department settings. This paper describes the development of educational materials on ASD and the results of training of emergency medical services and emergency department personnel.
C1 [McGonigle, John J.; Cramer, Ryan] Univ Pittsburgh, Western Psychiat Inst & Clin, Western Reg ASERT, Med Ctr, Pittsburgh, PA 15213 USA.
[Migyanka, Joann M.; Glor-Scheib, Susan J.] Indiana Univ Penn, Indiana, PA USA.
[Fratangeli, Jeffrey J.] Indiana Univ Penn, Coll Educ & Educ Technol, Indiana, PA USA.
[Hegde, Gajanan G.; Shang, Jennifer] Univ Pittsburgh, Katz Grad Sch Business, Pittsburgh, PA 15260 USA.
[Venkat, Arvind] Allegheny Gen Hosp, Dept Emergency Med, Allegheny Hlth Network, Pittsburgh, PA 15212 USA.
RP Venkat, A (reprint author), Allegheny Gen Hosp, Dept Emergency Med, Allegheny Hlth Network, 320 East North Ave, Pittsburgh, PA 15212 USA.
EM avenkat@wpahs.org
CR Autism society, 2013, AUT FACTS STAT
Autism society, 2013, SAF SOUND CAMP
Autism society, 2013, AB AUT
Centers for Disease Control and Prevention, 2010, NAT HOSP AMB MED SUR
Gurney JG, 2006, ARCH PEDIAT ADOL MED, V160, P825, DOI 10.1001/archpedi.160.8.825
Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
National Center for Health Care Statistics, 2013, HLTH US 2012 SPEC FE
Pennsylvania Department of Public Welfare Office of Developmental Programs Bureau of Autism Services and Autism Services Education Resources Training Collaboratives, 2011, 4 PENNS DEP PUBL WEL
Scarpinato N, 2010, J SPEC PEDIATR NURS, V15, P244, DOI 10.1111/j.1744-6155.2010.00244.x
Shellenbarger Teresa, 2004, J Emerg Nurs, V30, P278, DOI 10.1016/j.jen.2004.02.002
van Olejnik L., 2004, J EMERGENCY MED SERV, V29, P56
Venkat A, 2012, POSTGRAD MED J, V88, P472, DOI 10.1136/postgradmedj-2011-130727
NR 12
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2014
VL 44
IS 5
BP 1252
EP 1259
DI 10.1007/s10803-013-1962-0
PG 8
WC Psychology, Developmental
SC Psychology
GA AH7RD
UT WOS:000336330200024
PM 24091472
ER
PT J
AU Norbury, CF
Gemmell, T
Paul, R
AF Norbury, Courtenay Frazier
Gemmell, Tracey
Paul, Rhea
TI Pragmatics abilities in narrative production: a cross-disorder
comparison
SO JOURNAL OF CHILD LANGUAGE
LA English
DT Article
ID AUTISTIC-SPECTRUM DISORDERS; HIGH-FUNCTIONING CHILDREN; LANGUAGE
IMPAIRMENT; ASPERGER-SYNDROME; STORY; COHERENCE; ADULTS; SKILLS; MIND
AB We aimed to disentangle contributions of socio-pragmatic and structural language deficits to narrative competence by comparing the narratives of children with autism spectrum disorder (ASD; n=25), non-autistic children with language impairments (LI; n=23), and children with typical development (TD; n=27). Groups were matched for age (61/2 to 15 years; mean: 10;6) and non-verbal ability; ASD and TD groups were matched on standardized language scores. Despite distinct clinical presentation, children with ASD and LI produced similarly simple narratives that lacked semantic richness and omitted important story elements, when compared to TD peers. Pragmatic errors were common across groups. Within the LI group, pragmatic errors were negatively correlated with story macrostructure scores and with an index of semantic-pragmatic relevance. For the group with ASD, pragmatic errors consisted of comments that, though extraneous, did not detract from the gist of the narrative. These findings underline the importance of both language and socio-pragmatic skill for producing coherent, appropriate narratives.
C1 [Norbury, Courtenay Frazier] Univ London, Dept Psychol, Egham TW20 0EX, Surrey, England.
[Gemmell, Tracey] Winnebago Cty Special Educ Cooperat, Rockton, IL USA.
[Paul, Rhea] Univ Cattolica Sacro Cuore, I-20123 Milan, Italy.
RP Norbury, CF (reprint author), Univ London, Dept Psychol, Egham TW20 0EX, Surrey, England.
EM courtenay.norbury@rhul.ac.uk
CR American Psychiatric and Association, 2012, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Beaumont R, 2006, AUTISM, V10, P365, DOI 10.1177/1362361306064416
Berman R. A., 2009, CAMBRIDGE HDB CHILD, P354, DOI DOI 10.1017/CB09780511576164CB09780511576164
Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
BISHOP DVM, 1987, J SPEECH HEAR DISORD, V52, P156
Bishop DVM, 2010, BEHAV GENET, V40, P618, DOI 10.1007/s10519-010-9381-x
Boudreau D, 2008, TOP LANG DISORD, V28, P99
Bowyer-Crane C, 2008, J CHILD PSYCHOL PSYC, V49, P422, DOI 10.1111/j.1469-7610.2007.01849.x
BRUNER J, 1991, CRIT INQUIRY, V18, P1, DOI 10.1086/448619
CANTWELL D, 1978, J CHILD PSYCHOL PSYC, V19, P351, DOI 10.1111/j.1469-7610.1978.tb00481.x
Capps L., 2000, J ABNORMAL CHILD PSY, V28, P193
Chapman R., 2003, SYSTEMATIC ANAL LANG
Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
Cicourel A., 1996, PRAGMAT COGN, V4.2, P221, DOI 10.1075/pc.4.2.04cic
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
Conti-Ramsden G, 2006, J CHILD PSYCHOL PSYC, V47, P621, DOI 10.1111/j.1469-7610.2005.01584.x
Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
Dickinson D. K., 2001, BEGINNING LITERACY L, P313
Diehl JJ, 2006, J ABNORM CHILD PSYCH, V34, P87, DOI 10.1007/s10802-005-9003-x
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Eigsti I., 2010, RES AUTISM SPECT DIS, V5, P681
Elliot C. D., 1990, DIFFERENTIAL ABILITY
Gabig CS, 2008, LANG SPEECH HEAR SER, V39, P498, DOI 10.1044/0161-1461(2008/07-0023)
Garcia-Perez RM, 2008, J AUTISM DEV DISORD, V38, P156, DOI 10.1007/s10803-007-0379-z
Gemmell T., 2007, THESIS SO CONNECTICU
Goldman S, 2008, J AUTISM DEV DISORD, V38, P1982, DOI 10.1007/s10803-008-0588-0
Goldstein B, 2000, CULTURAL LINGUISTIC
HEATH SB, 1986, TOP LANG DISORD, V7, P84
Jolliffe T, 2000, PSYCHOL MED, V30, P1169, DOI 10.1017/S003329179900241X
KAPLAN RB, 1966, LANG LEARN, V16, P1, DOI 10.1111/j.1467-1770.1966.tb00804.x
Kelley E, 2010, RES AUTISM SPECT DIS, V4, P526, DOI 10.1016/j.rasd.2009.12.001
Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
Loucas T, 2008, J CHILD PSYCHOL PSYC, V49, P1184, DOI 10.1111/j.1469-7610.2008.01951.x
Loveland K. A., 1993, UNDERSTANDING OTHER, P247
LOVELAND KA, 1990, BRIT J DEV PSYCHOL, V8, P9
Manolitsi M, 2011, CHILD LANG TEACH THE, V27, P39, DOI 10.1177/0265659010369991
Mayer M., 1969, BOY DOG HIS FROG
Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
Norbury CF, 2005, BRIT J DEV PSYCHOL, V23, P383, DOI 10.1348/026151005X26732
Norbury CF, 2004, INT J LANG COMM DIS, V39, P345, DOI 10.1080/13682820410001654883
Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
O'Connell P., 1997, SPEECH LANGUAGE HEAR
Pankratz ME, 2007, LANG SPEECH HEAR SER, V38, P390, DOI 10.1044/0161-1461(2007/040)
Paul R., 2007, LANGUAGE DISORDERS I
Paul R., 1996, J SPEECH HEAR RES, V39, P99
Peng F., 1988, LANG SCI, V10, P193, DOI [10.1016/0388-0001(88)90012-5, DOI 10.1016/0388-0001(88)90012-5]
Polyani L., 1989, TELLING AM STORY STR
Reichow B., 2008, COMMUNICATION DISORD, V29, P169, DOI [10.1177/1525740108318697, DOI 10.1177/152574010831869720948979]
Renfrew C., 1969, BUS STORY
Semel E., 2006, CLIN EVALUATION LANG, V4th
Sheskin D.J., 2000, HDB PARAMETRIC NONPA
Stein N., 1979, NEW DIRECTIONS DISCO, V2, P53
Stothard SE, 1998, J SPEECH LANG HEAR R, V41, P407
Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
TAGERFLUSBERG H, 1995, APPL PSYCHOLINGUIST, V16, P241, DOI 10.1017/S0142716400007281
Tomblin J. B., 2011, INT J LANG COMM DIS, V46, P127, DOI [DOI 10.1111/J.1460-6984.2011.00017.X, 10.1111/j.1460-6984.2011.00017.x]
Verhoeven JS, 2012, CEREB CORTEX, V22, P2263, DOI 10.1093/cercor/bhr292
WATERHOUSE L, 1982, BRAIN LANG, V15, P307, DOI 10.1016/0093-934X(82)90062-1
Wechsler D., 2004, WECHSLER INTELLIGENC
Wechsler D, 1999, WECHSLER ABBREVIATED
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Whitehouse AJO, 2008, J COMMUN DISORD, V41, P319, DOI 10.1016/j.jcomdis.2008.01.002
NR 68
TC 2
Z9 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0305-0009
EI 1469-7602
J9 J CHILD LANG
JI J. Child Lang.
PD MAY
PY 2014
VL 41
IS 3
BP 485
EP 510
DI 10.1017/S030500091300007X
PG 26
WC Psychology, Developmental; Linguistics; Psychology, Experimental
SC Psychology; Linguistics
GA AG9RF
UT WOS:000335756400001
PM 23632039
ER
PT J
AU Orinstein, AJ
Helt, M
Troyb, E
Tyson, KE
Barton, ML
Eigsti, IM
Naigles, L
Fein, DA
AF Orinstein, Alyssa J.
Helt, Molly
Troyb, Eva
Tyson, Katherine E.
Barton, Marianne L.
Eigsti, Inge-Marie
Naigles, Letitia
Fein, Deborah A.
TI Intervention for Optimal Outcome in Children and Adolescents with a
History of Autism
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE autism spectrum disorder; optimal outcomes; intervention history;
medication
ID INTENSIVE BEHAVIORAL TREATMENT; ALTERNATIVE MEDICINE TREATMENTS;
SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; YOUNG-CHILDREN; COMMUNICATION;
COMPLEMENTARY; INDIVIDUALS; PREDICTORS
AB Objective:Autism spectrum disorders (ASDs) were once considered lifelong disorders, but recent findings indicate that some children with ASDs no longer meet diagnostic criteria for any ASD and reach normal cognitive function. These children are considered to have achieved optimal outcomes (OO). The present study aimed to retrospectively examine group differences in the intervention history of children and adolescents with OO and those with high-functioning autism (HFA).Method:The current study examined intervention histories in 25 individuals with OO and 34 individuals with HFA (current age, 8-21 years), who did not differ on age, sex, nonverbal intelligence, or family income. Intervention history was collected through detailed parent questionnaires.Results:Children in the OO group had earlier parental concern, received earlier referrals to specialists, and had earlier and more intensive intervention than those in the HFA group. Substantially more children with OO than HFA received applied behavior analysis (ABA) therapy, although for children who received ABA, the intensity did not differ between the groups. Children in the HFA group were more likely to have received medication, especially antipsychotics and antidepressants. There were no group differences in the percent of children receiving special diets or supplements.Conclusion:These data suggest that OO individuals generally receive earlier, more intense interventions, and more ABA, whereas HFA individuals receive more pharmacologic treatments. Although the use of retrospective data is a clear limitation to the current study, the substantial differences in the reported provision of early intervention, and ABA in particular, is highly suggestive and should be replicated in prospective studies.
C1 [Orinstein, Alyssa J.; Helt, Molly; Troyb, Eva; Tyson, Katherine E.; Barton, Marianne L.; Eigsti, Inge-Marie; Naigles, Letitia; Fein, Deborah A.] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
RP Orinstein, AJ (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd,Unit 1020, Storrs, CT 06269 USA.
EM alyssa.orinstein@uconn.edu
FU National Institutes of Mental Health [R01MH076189]
FX Supported by the National Institutes of Mental Health grant
(R01MH076189).
CR Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037
Frazier TW, 2011, J CHILD ADOL PSYCHOP, V21, P571, DOI 10.1089/cap.2011.0057
Gabriels RL, 2001, AUTISM, V5, P407, DOI 10.1177/1362361301005004006
Greenspan H, 2006, ENGAGING AUTISM USIN
Gresham FM, 1998, J AUTISM DEV DISORD, V28, P5, DOI 10.1023/A:1026002717402
Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
Huffman LC, 2011, J DEV BEHAV PEDIATR, V32, P56, DOI 10.1097/DBP.0b013e3182040acf
Hus V, 2011, J CHILD PSYCHOL PSYC, V52, P753, DOI 10.1111/j.1469-7610.2011.02398.x
Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
Leskovec TJ, 2008, HARVARD REV PSYCHIAT, V16, P97, DOI 10.1080/10673220802075852
Levy SE, 2008, CHILD ADOL PSYCH CL, V17, P803, DOI 10.1016/j.chc.2008.06.004
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Luiselli J. K., 2000, AUTISM, V4, P426, DOI 10.1177/1362361300004004007
Luyster R, 2005, DEV NEUROPSYCHOL, V27, P311, DOI 10.1207/s15326942dn2703_2
MCEACHIN JJ, 1993, AM J MENT RETARD, V97, P359
McEachin JJ, 1993, AM J MENT RETARD, V97, P373
MUNDY P, 1993, AM J MENT RETARD, V97, P381
Reichow B, 2012, COCHRANE DB SYST REV, V10
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
SCHOPLER E, 1989, J CONSULT CLIN PSYCH, V57, P162
Sheinkopf SJ, 1998, J AUTISM DEV DISORD, V28, P15, DOI 10.1023/A:1026054701472
Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
Sparrow S., 1985, VINELAND ADAPTIVE BE
Troyb E, 2013, AUTISM
Troyb E, 2013, CHILD NEUROPSYCHOL
Wechsler D, 1999, WECHSLER ABBREVIATED
NR 33
TC 3
Z9 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2014
VL 35
IS 4
BP 247
EP 256
DI 10.1097/DBP.0000000000000037
PG 10
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA AH3AZ
UT WOS:000335994900002
PM 24799263
ER
PT J
AU Gillette, MLD
Stough, CO
Beck, AR
Maliszewski, G
Best, CM
Gerling, JK
Summar, S
AF Gillette, Meredith L. Dreyer
Stough, Cathleen Odar
Beck, Amy R.
Maliszewski, Genevieve
Best, Cora M.
Gerling, Janelle K.
Summar, Shelly
TI Outcomes of a Weight Management Clinic for Children with Special Needs
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE childhood obesity; eating behaviors; autism spectrum disorders; Down
syndrome; intervention
ID RANDOMIZED CONTROLLED-TRIAL; DEVELOPMENTAL-DISABILITIES; PEDIATRIC
OBESITY; DOWN-SYNDROME; AUTISM; OVERWEIGHT; PREVALENCE; INTERVENTION;
ADOLESCENTS; BEHAVIORS
AB Objective:Rates of obesity are elevated among children with special needs (e.g., autism spectrum disorder, Down syndrome, or developmental disabilities). The objective of this study was to evaluate the effectiveness of a multidisciplinary tailored intervention to treat obesity among youth with special needs.Method:Seventy-six children aged 2 to 19 years participated in a multidisciplinary weight management clinic adapted for children with special needs. A description of the patients presenting for specialized clinical services is provided, and the impact of the intervention on child body mass index (BMI) and food variety was examined for a subset (n = 30) of children. Descriptive statistics of the patient population at baseline were calculated and a series of t tests, correlations, and analysis of variance models examined change in BMI z-scores (BMIz) and diet variety. Factors related to treatment outcomes were also explored.Results:BMIz decreased significantly by the 6-month follow-up (M = 2.43 to M = 2.36, p < .01). There were significant increases in the variety of fruits, vegetables, and grains that children ate (t(16) = 3.18, p < .01; t(16) = 2.63, p = .02; t(16) = 2.37, p = .03, respectively).Conclusion:A multidisciplinary clinic-based intervention was effective in reducing BMIz over a 6-month period and increasing the variety of foods that children were eating. These results have implications for providing tailored weight management interventions for youth with obesity and special needs.
C1 [Gillette, Meredith L. Dreyer; Beck, Amy R.] Childrens Mercy Hosp, Dept Pediat Dev & Behav Sci, Kansas City, MO 64108 USA.
[Gillette, Meredith L. Dreyer; Beck, Amy R.; Best, Cora M.; Gerling, Janelle K.; Summar, Shelly] Childrens Mercy Hosp, Dept Pediat, Kansas City, MO 64108 USA.
[Gillette, Meredith L. Dreyer; Stough, Cathleen Odar; Beck, Amy R.] Ctr Childrens Healthy Lifestyles & Nutr, Kansas City, MO USA.
[Stough, Cathleen Odar] Univ Kansas, Clin Child Psychol Program, Lawrence, KS 66045 USA.
[Maliszewski, Genevieve] Univ Missouri, Dept Counseling & Educ Psychol, Kansas City, MO 64110 USA.
[Gerling, Janelle K.] Childrens Mercy Hosp, Dept Allied Hlth Profess Phys & Occupat Therapy, Kansas City, MO 64108 USA.
RP Gillette, MLD (reprint author), Childrens Mercy Hosp, 2401 Gillham Rd, Kansas City, MO 64108 USA.
EM mldreyer@cmh.edu
FU Healthcare Foundation of Greater Kansas City; Kenneth and Eva S. Smith
Scholar in Pediatric Obesity Award
FX The study was supported by funding from the Healthcare Foundation of
Greater Kansas City and the Kenneth and Eva S. Smith Scholar in
Pediatric Obesity Award. The authors declare no conflict of interest.
CR Bandini LG, 2010, J PEDIATR-US, V157, P259, DOI 10.1016/j.jpeds.2010.02.013
Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C
Block ME, 1991, ADAPTED PHYSICAL ACT, V8, P179
CRONK C, 1988, PEDIATRICS, V81, P102
Curtin C, 2010, BMC PEDIATR, V10, DOI 10.1186/1471-2431-10-11
De S, 2008, J INTELLECT DEV DIS, V33, P43, DOI 10.1080/13668250701875137
EPSTEIN LH, 1994, HEALTH PSYCHOL, V13, P373, DOI 10.1037/0278-6133.13.5.373
Gallagher KS, 2011, J PEDIATR PSYCHOL, V36, P687, DOI 10.1093/jpepsy/jsr011
Golley RK, 2007, PEDIATRICS, V119, P517, DOI 10.1542/peds.2006-1746
Gupta VB, 2007, J DEV PHYS DISABIL, V19, P417, DOI 10.1007/s10882-007-9060-x
Holcomb MJ, 2009, PSYCHOL SCHOOLS, V46, P797, DOI 10.1002/pits.20418
Irby M. B., 2012, ICAN: Infant, Child & Adolescent Nutrition, V4, P215, DOI 10.1177/1941406412448527
Levine MD, 2001, INT J EAT DISORDER, V30, P318, DOI 10.1002/eat.1091
LUKE A, 1994, J PEDIATR-US, V125, P829, DOI 10.1016/S0022-3476(94)70087-7
McGovern L, 2008, J CLIN ENDOCR METAB, V93, P4600, DOI 10.1210/jc.2006-2409
Obrusnikova I, 2011, J DEV PHYS DISABIL, V23, P195, DOI 10.1007/s10882-010-9215-z
Page J., 1998, CHILD LANG TEACH THE, V14, P233, DOI 10.1191/026565998673400901
Pott W, 2009, INT J EAT DISORDER, V42, P284, DOI 10.1002/eat.20655
Provost B, 2010, PHYS OCCUP THER PEDI, V30, P220, DOI 10.3109/01942631003757669
Reinehr T, 2010, AM J CLIN NUTR, V91, P1165, DOI 10.3945/ajcn.2009.28705
Rimmer JA, 2008, DEV NEUROREHABIL, V11, P141, DOI 10.1080/17518420701688649
Rimmer JH, 2011, PREV CHRONIC DIS, V8
RODRIGUE JR, 1992, J AUTISM DEV DISORD, V22, P249, DOI 10.1007/BF01058154
Saunders M, 2008, FOOD PREFERENCE ASSE
Savoye M, 2007, JAMA-J AM MED ASSOC, V297, P2697, DOI 10.1001/jama.297.24.2697
Schieve LA, 2007, PEDIATRICS, V119, P5114
Schreck KA, 2004, J AUTISM DEV DISORD, V34, P433, DOI 10.1023/B:JADD.0000037419.78531.86
Steele RG, 2012, J PEDIATR PSYCHOL, V37, P53, DOI 10.1093/jpepsy/jsr057
Stewart L, 2009, J INTELL DISABIL RES, V53, P882, DOI 10.1111/j.1365-2788.2009.01200.x
Toomey KA, 2011, DYSPHAGIA, V20, P82
NR 30
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2014
VL 35
IS 4
BP 266
EP 273
DI 10.1097/DBP.0000000000000055
PG 8
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA AH3AZ
UT WOS:000335994900004
PM 24799265
ER
PT J
AU Rumsey, RK
Rudser, K
Delaney, K
Potegal, M
Whitley, CB
Shapiro, E
AF Rumsey, Robin K.
Rudser, Kyle
Delaney, Kathleen
Potegal, Michael
Whitley, Chester B.
Shapiro, Elsa
TI Acquired Autistic Behaviors in Children with Mucopolysaccharidosis Type
IIIA
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID SANFILIPPO SYNDROME; PREVALENCE; DISORDERS
AB Objectives To assess autism spectrum disorder (ASD) behaviors in children with mucopolysaccharidosis type IIIA (MPS IIIA) using a standard measure, understand the behavioral evolution of the disease, and provide specific guidelines for diagnosis.
Study design Children (n = 21) with documented enzyme deficiency and SGSH gene mutations, cognitive age-equivalent >12 months, and early onset were administered the Autism Diagnostic Observation Schedule (ADOS) (module 1) and Bayley Scales of Infant Development-Third Edition. ADOS Social Affect and Restricted Repetitive Behavior total scores, as well as Bayley Scales of Infant Development-Third Edition cognitive age-equivalent scores, are reported using descriptive statistics and graphic presentations.
Results Thirteen of the 21 children evaluated met the ADOS criteria for ASD/autism. ADOS score was strongly associated with age; all 11 children aged >46 months met the criteria, compared with only 2 of 10 aged <46 months. Social and affective abnormalities were most frequent; restricted interests and repetitive behaviors were largely absent. Lack of cognitive growth paralleled ADOS score.
Conclusion An increased incidence of ASD-like social behaviors was seen at age 3-4 years in children with early-onset MPS IIIA. Although more frequent in the severely impaired children, ASD-like behaviors were observed across the entire range of cognitive impairment. Clinicians must be aware that when a child acquires ASD-like behaviors, MPS IIIA should be included in the differential diagnosis.
C1 [Rumsey, Robin K.; Delaney, Kathleen; Potegal, Michael; Whitley, Chester B.; Shapiro, Elsa] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
[Rudser, Kyle] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
RP Rumsey, RK (reprint author), Autism Spectrum & Neurodev Disorders Clin, 717 Delaware St SE,Suite 340, Minneapolis, MN 55414 USA.
EM rumse002@umn.edu
FU National Institute of Neurological Disorders and Stroke [U54NS065768]
FX We would like to acknowledge the University of Minnesota Autism Spectrum
and Neurodevelopmental Disorders Clinic; the Center for Neurobehavioral
Development; Amy Esler, PhD (University of Minnesota Autism Spectrum and
Neurodevelopmental Disorders Clinic), who conducted several of the ADOS
assessments; Brianna Yund (funded by National Institute of Neurological
Disorders and Stroke [U54NS065768]), who entered the data; and the
families who helped advance research by participating in this study. We
thank Patrick Haslett, MD (employee of Shire Pharmaceuticals) for his
role in designing the overall trial and assistance in reviewing the
initial manuscript.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Baehner F, 2005, J INHERIT METAB DIS, V28, P1011, DOI 10.1007/s10545-005-0112-z
Bayley N, 2006, BAYLEY SCALES INFANT, V3rd
CLEARY MA, 1993, ARCH DIS CHILD, V69, P403
Cohen D, 2005, J AUTISM DEV DISORD, V35, P103, DOI 10.1007/s10803-004-1038-2
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Heron B, 2011, AM J MED GENET A, V155A, P58, DOI 10.1002/ajmg.a.33779
Hopwood John J., 2007, P415, DOI 10.1007/978-0-387-70909-3_26
Irie F, 2012, P NATL ACAD SCI USA, V109, P5052, DOI 10.1073/pnas.1117881109
Jabourian A, 2011, ANN MED-PSYCHOL, V160, P421
Lord C, 1999, PSYCHOL SERVICES
Malm G, 2008, ACTA PAEDIATR, V97, P1577, DOI 10.1111/j.1651-2227.2008.00965.x
Meikle PJ, 1999, JAMA-J AM MED ASSOC, V281, P249, DOI 10.1001/jama.281.3.249
Poorthuis BJHM, 1999, HUM GENET, V105, P151, DOI 10.1007/s004399900075
Potegal M, 2012, MOL GENET METAB, V105, pS53, DOI 10.1016/j.ymgme.2011.11.137
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Umeda S, 2010, SOC NEUROSCI-UK, V5, P19, DOI 10.1080/17470910902990584
Whitley CB, 2012, MOL GENET METAB, V105, pS58, DOI 10.1016/j.ymgme.2011.11.152
Wijburg FA, 2013, ACTA PAEDIATR, V102, P462, DOI 10.1111/apa.12169
NR 19
TC 2
Z9 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD MAY
PY 2014
VL 164
IS 5
BP 1147
EP +
DI 10.1016/j.jpeds.2014.01.007
PG 6
WC Pediatrics
SC Pediatrics
GA AG6GB
UT WOS:000335516000041
PM 24582005
ER
PT J
AU Semino, E
AF Semino, Elena
TI Pragmatic failure, mind style and characterisation in fiction about
autism
SO LANGUAGE AND LITERATURE
LA English
DT Article
DE Autism; Theory of Mind; Grice; fiction; pragmatic failure; figurative
language; impoliteness; mind style; metaphor; characterisation
ID LANGUAGE; CHILDREN
AB This article presents an analysis of different types of pragmatic failure in the interactional behaviour of the 'autistic' protagonists of three recent novels. Three main types of pragmatic failure occur across all three novels: problems with informativeness and relevance in conversational contributions; problems with face management resulting in unintentional impolite behaviours; and problems with the interpretation of figurative language. These problems are salient and frequent enough to contribute to the projection of distinctive mind styles, and more generally to the characterisation of the protagonists as individuals with communication and socialisation difficulties that are likely to both reflect and reinforce general perceptions of autism-spectrum disorders. It is also argued that pragmatic failure contributes to the potential defamiliarisation of 'normal' communication, which is presented as being fraught with obscurity, ambiguity and insincerity.
C1 [Semino, Elena] Univ Lancaster, Lancaster LA1 4YL, England.
RP Semino, E (reprint author), Univ Lancaster, Dept Linguist & English Language, Lancaster LA1 4YL, England.
EM e.semino@lancaster.ac.uk
CR Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Bates G, 2010, ADV PSYCHIAT TREATME, V16, P47
Bockting I, 1995, CHARACTER PERSONALIT
Bousfield Derek, 2008, IMPOLITENESS INTERAC
Brown P., 1987, POLITENESS SOME UNIV
Cook Guy, 1994, DISCOURSE LIT INTERP
Culpeper Jonathan, 2011, IMPOLITENESS USING L
Culpeper Jonathan, 2001, LANGUAGE CHARACTERIS
Cummings L, 2009, CLINICAL PRAGMATICS, P1
Draaisma D, 2009, PHILOS T R SOC B, V364, P1475, DOI 10.1098/rstb.2008.0324
Fanlo Pinies M, 2005, THESIS LANCASTER U
Fowler R, 1986, LINGUISTIC CRITICISM
Fowler Roger, 1977, LINGUISTICS NOVEL
Giora R, 2012, METAPHOR SYMBOL, V27, P1, DOI 10.1080/10926488.2012.638807
Goatly Andrew, 1997, LANGUAGE METAPHORS
Goffman E, 1967, INTERACTION RITUAL E
Greenwell B, 2004, CHILD LIT EDUC, V35, P271, DOI 10.1023/B:CLID.0000041783.90370.14
Grice H. Paul, 1989, STUDIES WAY WORDS
Haddon M., 2003, CURIOUS INCIDENT DOG
Haddon M, 2009, ASPERGERS AUTISM
HAPPE FGE, 1995, METAPHOR SYMB ACT, V10, P275, DOI 10.1207/s15327868ms1004_3
Hobson RP, 2012, METAPHOR SYMBOL, V27, P4, DOI 10.1080/10926488.2012.638814
Horn Laurence R., 2004, HDB PRAGMATICS, P3
JAWORSKI A, 1994, IRAL-INT REV APPL LI, V32, P41, DOI 10.1515/iral.1994.32.1.41
Jeffries Lesley, 2010, STYLISTICS
Kanner L, 1943, NERV CHILD, V2, P217
Landa R, 2009, ASPERGER SYNDROME, P125
Leech Geoffrey, 1981, STYLE FICTION
Leech Geoffrey N., 1983, PRINCIPLES PRAGMATIC
Levinson Stephen, 2000, PRESUMPTIVE MEANINGS
Loukusa S, 2007, J AUTISM DEV DISORD, V37, P1049, DOI 10.1007/s10803-006-0247-2
Margolin Uri, 2003, NARRATIVE THEORY COG, P271
Marmaridou S, 2011, FDN PRAGMATICS, P77
Moon E, 2002, SPEED DARK
Morrall C, 2008, LANGUAGE OTHERS
Palmer Alan, 2004, FICTIONAL MINDS
Pijnacker J, 2009, J AUTISM DEV DISORD, V39, P607, DOI 10.1007/s10803-008-0661-8
Reboul A, 2012, COGNITIVE PRAGMATICS, P317
Semino E, 2007, STYLE, V41, P153
Semino E, 1995, LANG LIT, V4, P79, DOI 10.1177/096394709500400201
SEMINO E, 1996, STYLE, V30, P143
Semino E, 2011, STYLE, V45, P418
Semino E, 2002, COGNITIVE STYLISTICS, P95
Semino E, 2014, LINGUAE LITT, V31, P279
Semino Elena, 1997, LANGUAGE WORLD CREAT
Shklovsky V, 1965, RUSSIAN FORMALIST CR, P2
Short M, 1996, EXPLORING LANGUAGE P
Sperber D., 1995, RELEVANCE COMMUNICAT
Sperber D., 1986, RELEVANCE COMMUNICAT
Talwar V, 2012, FOCUS AUTISM DEV DIS, V27, P122, DOI 10.1177/1088357612441828
THOMAS J, 1983, APPL LINGUIST, V4, P91, DOI 10.1093/applin/4.2.91
Thomas Jenny, 1995, MEANING INTERACTION
Wilson D., 2004, HDB PRAGMATICS, P607
Wing L, 2002, MENT RETARD DEV D R, V8, P151, DOI 10.1002/mrdd.10029
NR 55
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0963-9470
EI 1461-7293
J9 LANG LIT
JI Lang. Lit.
PD MAY
PY 2014
VL 23
IS 2
BP 141
EP 158
DI 10.1177/0963947014526312
PG 18
WC Linguistics; Language & Linguistics
SC Linguistics
GA AG9UR
UT WOS:000335765900003
ER
PT J
AU Naviaux, RK
AF Naviaux, Robert K.
TI Metabolic features of the cell danger response
SO MITOCHONDRION
LA English
DT Article
DE Oxidative stress; Oxidative shielding; Innate immunity; Inflammation;
Purinergic signaling; Mitochondria
ID INNATE IMMUNE-RESPONSES; CYSTINE/GLUTAMATE ANTIPORTER; PYRIMIDINE
METABOLISM; AUTOIMMUNE-DISEASE; IMPROVES RECOVERY; OXIDATIVE-STRESS; ATP
RELEASE; LUNG INJURY; KAPPA-B; RECEPTOR
AB The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. The resulting metabolic mismatch between available resources and functional capacity produces a cascade of changes in cellular electron flow, oxygen consumption, redox, membrane fluidity, lipid dynamics, bioenergetics, carbon and sulfur resource allocation, protein folding and aggregation, vitamin availability, metal homeostasis, indole, pterin, 1-carbon and polyamine metabolism, and polymer formation. The first wave of danger signals consists of the release of metabolic intermediates like ATP and ADP, Krebs cycle intermediates, oxygen, and reactive oxygen species (ROS), and is sustained by purinergic signaling. After the danger has been eliminated or neutralized, a choreographed sequence of anti-inflammatoty and regenerative pathways is activated to reverse the CDR and to heal. When the CDR persists abnormally, whole body metabolism and the gut microbiome are disturbed, the collective performance of multiple organ systems is impaired, behavior is changed, and chronic disease results. Metabolic memory of past stress encounters is stored in the form of altered mitochondrial and cellular macromolecule content, resulting in an increase in functional reserve capacity through a process known as mitocellular hormesis. The systemic form of the CDR, and its magnified form, the purinergic life-threat response (PLTR), are under direct control by ancient pathways in the brain that are ultimately coordinated by centers in the brainstem. Chemosensory integration of whole body metabolism occurs in the brainstem and is a prerequisite for normal brain, motor, vestibular, sensory, social, and speech development. An understanding of the CDR permits us to reframe old concepts of pathogenesis for a broad array of chronic, developmental, autoimmune, and degenerative disorders. These disorders include autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), asthma, atopy, gluten and many other food and chemical sensitivity syndromes, emphysema, Tourette's syndrome, bipolar disorder, schizophrenia, post-traumatic stress disorder (PTSD), chronic traumatic encephalopathy (CTE), traumatic brain injury (TB!), epilepsy, suicidal ideation, organ transplant biology, diabetes, kidney, liver, and heart disease, cancer, Alzheimer and Parkinson disease, and autoimmune disorders like lupus, rheumatoid arthritis, multiple sclerosis, and primary sclerosing cholangitis. (C) 2013 The Author. Published by Elsevier B.V. and Mitochondria Research Society. All rights reserved.
C1 [Naviaux, Robert K.] Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, Dept Med, San Diego, CA 92103 USA.
[Naviaux, Robert K.] Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, Dept Pediat, San Diego, CA 92103 USA.
[Naviaux, Robert K.] Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, Dept Pathol, San Diego, CA 92103 USA.
[Naviaux, Robert K.] Vet Affairs Ctr Excellence Stress & Mental Hlth C, La Jolla, CA USA.
RP Naviaux, RK (reprint author), Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, 214 Dickinson St,Bldg CTF,Rm C102, San Diego, CA 92103 USA.
EM Naviaux@ucsd.edu
FU UCSD Christini Fund; Jane Botsford Johnson Foundation; Wright
Foundation; Lennox Foundation; Takes Guts Foundation; UCSD Mitochondrial
Disease Research Foundation; Hailey's Wish Foundation
FX RKN thanks Jane Naviaux, Will Alaynick, Jim Adams, Steve Edelson, Kate
Crowley, and Vicki Kobliner for helpful comments on the manuscript. This
work was made possible by support from the UCSD Christini Fund, the Jane
Botsford Johnson Foundation, the Wright Foundation, the Lennox
Foundation, the It Takes Guts Foundation, the UCSD Mitochondrial Disease
Research Foundation, and the Hailey's Wish Foundation.
CR Ajioka RS, 2006, BBA-MOL CELL RES, V1763, P723, DOI 10.1016/j.bbamcr.2006.05.005
Amoult D., 2011, EMBO REP, V12, P901
Angata T, 2012, ANN NY ACAD SCI, V1253, P159, DOI 10.1111/j.1749-6632.2012.06469.x
Arispe N, 2002, FASEB J, V16, P1526, DOI 10.1096/fj.02-0829com
Bachrach U, 2007, AMINO ACIDS, V33, P267, DOI 10.1007/s00726-007-0535-y
Ballok DA, 2008, BRAIN BEHAV IMMUN, V22, P1208, DOI 10.1016/j.bbi.2008.06.002
Bernstein HG, 2012, NEUROPHARMACOLOGY, V62, P237, DOI 10.1016/j.neuropharm.2011.07.012
Bezvenyuk Z, 2000, NEUROSCI LETT, V292, P111, DOI 10.1016/S0304-3940(00)01453-1
Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
Bours Martijn Jan Leo, 2011, Front Biosci (Schol Ed), V3, P1443
Bridges RJ, 2012, BRIT J PHARMACOL, V165, P20, DOI 10.1111/j.1476-5381.2011.01480.x
Burnstock G, 2009, ACTA PHYSIOL, V195, P415, DOI 10.1111/j.1748-1716.2009.01957.x
BURNSTOC.G, 1972, BRIT J PHARMACOL, V44, P451
Burnstock G, 2012, CURR OPIN PHARMACOL, V12, P80, DOI 10.1016/j.coph.2011.10.008
Burnstock G, 2011, PROG NEUROBIOL, V95, P229, DOI 10.1016/j.pneurobio.2011.08.006
Burnstock G, 2010, ACTA PHYSIOL, V199, P93, DOI 10.1111/j.1748-1716.2010.02114.x
Caccamo D, 2012, AMINO ACIDS, V42, P1037, DOI 10.1007/s00726-011-1018-8
Cantin LD, 2012, BIOORG MED CHEM LETT, V22, P2565, DOI 10.1016/j.bmcl.2012.01.124
Cervelli M, 2012, AMINO ACIDS, V42, P441, DOI 10.1007/s00726-011-1014-z
Choo AM, 2013, BRAIN, V136, P65, DOI 10.1093/brain/aws286
Cicko S, 2010, J IMMUNOL, V185, P688, DOI 10.4049/jimmunol.0904042
Corcoran JA, 2009, J VIROL, V83, P2601, DOI 10.1128/JVI.02087-08
Darwin C.R., 1839, C DARWIN AUSTR, P30
de Oliveira Moreira D., 2013, MUSCLE NERVE
De Clercq E, 2009, MED RES REV, V29, P611, DOI 10.1002/med.20153
Degtyar E, 2009, CELL MICROBIOL, V11, P1219, DOI 10.1111/j.1462-5822.2009.01328.x
DiNatale BC, 2010, TOXICOL SCI, V115, P89, DOI 10.1093/toxsci/kfq024
Dreifus C, 1998, NY TIMES
Edmonds JL, 2002, ARCH OTOLARYNGOL, V128, P355
Ehlert U., 2013, PSYCHONEUROENDOCRINO
Eisner V, 2010, CELL CALCIUM, V48, P358, DOI 10.1016/j.ceca.2010.11.001
Engel T, 2012, FASEB J, V26, P1616, DOI 10.1096/fj.11-196089
Fontecave M, 2004, TRENDS BIOCHEM SCI, V29, P243, DOI 10.1016/j.tibs.2004.03.007
Forstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
Fuchs E J, 1996, Semin Immunol, V8, P271, DOI 10.1006/smim.1996.0035
Fulkerson PC, 2013, NAT REV DRUG DISCOV, V12, P117, DOI 10.1038/nrd3838
Garrod AE, 1902, LANCET, V2, P1616
Gray TJ, 1999, J CARDIOVASC PHARM, V33, P960, DOI 10.1097/00005344-199906000-00018
Gunderson LH, 2000, ANNU REV ECOL SYST, V31, P425, DOI 10.1146/annurev.ecolsys.31.1.425
Halassa MM, 2011, SEMIN CELL DEV BIOL, V22, P245, DOI 10.1016/j.semcdb.2011.02.008
Haynes CM, 2013, TRENDS CELL BIOL, V23, P311, DOI 10.1016/j.tcb.2013.02.002
He SQ, 2013, J PHARMACOL EXP THER, V344, P417, DOI 10.1124/jpet.112.199919
HeberKatz E, 2013, CURR TOP MICROBIOL, V367, P1, DOI 10.1007/978-3-642-35810-4
Hecker L, 2009, NAT MED, V15, P1077, DOI 10.1038/nm.2005
HSU HC, 1994, AUTOIMMUNITY, V19, P253, DOI 10.3109/08916939409071351
Hultqvist M, 2009, TRENDS IMMUNOL, V30, P201, DOI 10.1016/j.it.2009.03.004
Ibrahim D, 2006, CLIN LAB MED, V26, P67, DOI 10.1016/j.cll.2006.02.003
Jacobs SA, 2007, MED HYPOTHESES, V68, P308, DOI 10.1016/j.mehy.2006.07.023
Jiang XM, 2012, IMMUNITY, V36, P959, DOI 10.1016/j.immuni.2012.03.022
Jin S, 2009, CURR ATHEROSCLER REP, V11, P220, DOI 10.1007/s11883-009-0034-6
Junger WG, 2011, NAT REV IMMUNOL, V11, P201, DOI 10.1038/nri2938
Kannan KB, 2007, J IMMUNOL, V178, P5253
KAWAMURA M, 1991, JPN J PHARMACOL, V56, P543, DOI 10.1254/jjp.56.543
Kharlamov A, 2002, EXP BRAIN RES, V147, P353, DOI 10.1007/s00221-002-1251-1
Kim HJ, 2012, BBA-MOL CELL RES, V1823, P1604, DOI 10.1016/j.bbamcr.2012.04.008
Kim HP, 2006, EXPERT OPIN THER TAR, V10, P759, DOI 10.1517/14728222.10.5.759
Kivity S, 2011, CELL MOL IMMUNOL, V8, P243, DOI 10.1038/cmi.2010.73
Knight JC, 2013, TRENDS GENET, V29, P74, DOI 10.1016/j.tig.2012.10.006
Kobayashi S, 2012, FREE RADICAL BIO MED, V53, P2197, DOI 10.1016/j.freeradbiomed.2012.09.040
Korrapati MC, 2012, J PHARMACOL EXP THER, V343, P34, DOI 10.1124/jpet.112.196964
Kruidenier L, 2012, NATURE, V488, P404, DOI 10.1038/nature11262
Kuijpers T, 2012, CELL MOL LIFE SCI, V69, P7, DOI 10.1007/s00018-011-0834-z
Landrigan PJ, 2012, ENVIRON HEALTH PERSP, V120, pA258, DOI 10.1289/ehp.1104285
Lee AH, 2009, CELL MOL LIFE SCI, V66, P2835, DOI 10.1007/s00018-009-0049-8
LESCH M, 1964, AM J MED, V36, P561, DOI 10.1016/0002-9343(64)90104-4
Lewerenz J, 2013, ANTIOXID REDOX SIGN, V18, P522, DOI 10.1089/ars.2011.4391
Liu C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052703
Liu GG, 2008, BIOCHEM BIOPH RES CO, V370, P651, DOI 10.1016/j.bbrc.2008.04.031
Liu GW, 2010, NAT IMMUNOL, V11, P1047, DOI 10.1038/ni.1939
Lluis JM, 2007, CANCER RES, V67, P7368, DOI 10.1158/0008-5472.CAN-07-0515
Lucki NC, 2012, ANNU REV PHYSIOL, V74, P131, DOI 10.1146/annurev-physiol-020911-153321
Lushchak VI, 2010, COMP BIOCH PHYSL C, V153, P175
MacLennan AJ, 2006, HEARING RES, V220, P38, DOI 10.1016/j.heares.2006.06.016
Mahankali M, 2011, P NATL ACAD SCI USA, V108, P19617, DOI 10.1073/pnas.1114692108
Mandi Y, 2012, J NEURAL TRANSM, V119, P197, DOI 10.1007/s00702-011-0681-y
Marina N, 2013, BASIC RES CARDIOL, V108, DOI 10.1007/s00395-012-0317-x
Matzinger P, 2011, NAT REV IMMUNOL, V11, P221, DOI 10.1038/nri2940
MATZINGER P, 1994, ANNU REV IMMUNOL, V12, P991, DOI 10.1146/annurev.iy.12.040194.005015
McLain AL, 2013, FREE RADICAL BIO MED, V61, P161, DOI 10.1016/j.freeradbiomed.2013.03.020
Micheli V, 2011, CURR TOP MED CHEM, V11, P923
Nathanson N, 2010, AM J EPIDEMIOL, V172, P1213, DOI 10.1093/aje/kwq320
Naviaux RK, 2008, CANCER BIOL THER, V7, P1191
Naviaux RK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057380
Naviaux RK, 2012, J PHARMACOL EXP THER, V342, P608, DOI 10.1124/jpet.112.192120
Nie XW, 2013, INT J BIOCHEM CELL B, V45, P964, DOI 10.1016/j.biocel.2013.01.017
Nielsen MJ, 2012, NAT REV GASTRO HEPAT, V9, P345, DOI 10.1038/nrgastro.2012.76
NovalesLi P, 1996, IMMUNOPHARMACOLOGY, V35, P155, DOI 10.1016/S0162-3109(96)00141-5
Novgorodov Sergei A, 2011, Int J Biochem Mol Biol, V2, P347
NYHAN WL, 1969, J PEDIATR, V74, P20, DOI 10.1016/S0022-3476(69)80004-1
Nyhan WL, 2005, MOL GENET METAB, V86, P25, DOI 10.1016/j.ymgme.2005.07.027
Oguma T, 2007, CLIN EXP ALLERGY, V37, P893, DOI 10.1111/j.1365-2222.2007.02719.x
Ohta A, 2011, MITOCHONDRION, V11, P1, DOI 10.1016/j.mito.2010.08.006
Ong WY, 2010, CURR MED CHEM, V17, P2746
Panossian Alexander, 2009, Curr Clin Pharmacol, V4, P198
Pastural E, 2009, PROSTAG LEUKOTR ESS, V81, P253, DOI 10.1016/j.plefa.2009.06.003
Paul L, 2013, NUTR REV, V71, P239, DOI 10.1111/nure.12014
Peng WG, 2009, P NATL ACAD SCI USA, V106, P12489, DOI 10.1073/pnas.0902531106
Peng X, 2012, ACTA PHYSIOL, V204, P219, DOI 10.1111/j.1748-1716.2011.02298.x
Pimentel VC, 2013, NEUROCHEM RES, V38, P886, DOI 10.1007/s11064-013-0994-3
Rabiet MJ, 2005, EUR J IMMUNOL, V35, P2486, DOI 10.1002/eji.200526338
Riegl B, 2009, ANN NY ACAD SCI, V1162, P136, DOI 10.1111/j.1749-6632.2009.04493.x
Riteau N, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.144
Romero P, 2005, GENOME BIOL, V6
Sahu D, 2012, INT IMMUNOPHARMACOL, V12, P288, DOI 10.1016/j.intimp.2011.12.003
Salminen A, 2012, AGEING RES REV, V11, P230, DOI 10.1016/j.arr.2011.12.005
Scott I, 2010, MITOCHONDRION, V10, P316, DOI 10.1016/j.mito.2010.02.005
Sentelle RD, 2012, NAT CHEM BIOL, V8, P831, DOI 10.1038/NCHEMBIO.1059
Seong SY, 2004, NAT REV IMMUNOL, V4, P469, DOI 10.1038/nri1372
Seth RB, 2005, CELL, V122, P669, DOI 10.1016/j.cell.2005.08.012
Shanmugasundaram R, 2012, POULTRY SCI, V91, P1819, DOI 10.3382/ps.2011-02129
Silva JM, 2009, NEUROBIOL DIS, V34, P357, DOI 10.1016/j.nbd.2009.02.005
Smriga M, 2003, P NATL ACAD SCI USA, V100, P15370, DOI 10.1073/pnas.2436556100
Stipanuk MH, 2011, J INHERIT METAB DIS, V34, P17, DOI 10.1007/s10545-009-9006-9
SUTTON RAL, 1993, MINER ELECTROL METAB, V19, P232
Takabe K, 2008, PHARMACOL REV, V60, P181, DOI 10.1124/pr.107.07113
Thompson CR, 2005, J IMMUNOL, V174, P3551
West AP, 2011, NAT REV IMMUNOL, V11, P389, DOI 10.1038/nri2975
Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
Wood JH, 2010, CURR OPIN PEDIATR, V22, P315, DOI 10.1097/MOP.0b013e328338da48
Xia JS, 2012, J PHYSIOL-LONDON, V590, P2285, DOI 10.1113/jphysiol.2012.227983
Yang Z, 2012, OBES REV, V13, P58, DOI 10.1111/j.1467-789X.2012.01038.x
Yousefi S, 2008, NAT MED, V14, P949, DOI 10.1038/nm.1855
Zamek-Gliszczynski MJ, 2006, EUR J PHARM SCI, V27, P447, DOI 10.1016/j.ejps.2005.12.007
Zhang XY, 2011, AM J PHYSIOL-CELL PH, V301, pC451, DOI 10.1152/ajpcell.00458.2010
Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
NR 125
TC 8
Z9 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD MAY
PY 2014
VL 16
SI SI
BP 7
EP 17
DI 10.1016/j.mito2013.08.006
PG 11
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA AH9OP
UT WOS:000336472000003
PM 23981537
ER
PT J
AU Harrington, RA
Lee, LC
Crum, RM
Zimmerman, AW
Hertz-Picciotto, I
AF Harrington, Rebecca A.
Lee, Li-Ching
Crum, Rosa M.
Zimmerman, Andrew W.
Hertz-Picciotto, Irva
TI Prenatal SSRI Use and Offspring With Autism Spectrum Disorder or
Developmental Delay
SO PEDIATRICS
LA English
DT Article
DE selective serotonin reuptake inhibitors; autism; developmental delay;
pregnancy; epidemiology
ID SEROTONIN REUPTAKE INHIBITORS; ANTIDEPRESSANT MEDICATIONS; MATERNAL
DEPRESSION; PLATELET SEROTONIN; BRAIN-DEVELOPMENT; PREGNANCY; EXPOSURE;
POPULATION; RISK; TRANSPORTER
AB OBJECTIVE:To examine associations between prenatal use of selective serotonin reuptake inhibitors (SSRIs) and the odds of autism spectrum disorders (ASDs) and other developmental delays (DDs).METHODS:A total of 966 mother-child pairs were evaluated (492 ASD, 154 DD, 320 typical development [TD]) from the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study, a population-based case-control study. Standardized measures confirmed developmental status. Interviews with biological mothers ascertained prenatal SSRI use, maternal mental health history, and sociodemographic information.RESULTS:Overall, prevalence of prenatal SSRI exposure was lowest in TD children (3.4%) but did not differ significantly from ASD (5.9%) or DD (5.2%) children. Among boys, prenatal SSRI exposure was nearly 3 times as likely in children with ASD relative to TD (adjusted odds ratio [OR]: 2.91; 95% confidence interval [CI]: 1.07-7.93); the strongest association occurred with first-trimester exposure (OR: 3.22; 95% CI: 1.17-8.84). Exposure was also elevated among boys with DD (OR: 3.39; 95% CI: 0.98-11.75) and was strongest in the third trimester (OR: 4.98; 95% CI: 1.20-20.62). Findings were similar among mothers with an anxiety or mood disorder history.CONCLUSIONS:In boys, prenatal exposure to SSRIs may increase susceptibility to ASD or DD. Findings from published studies on SSRIs and ASD continues to be inconsistent. Potential recall bias and residual confounding by indication are concerns. Larger samples are needed to replicate DD results. Because maternal depression itself carries risks for the fetus, the benefits of prenatal SSRI use should be carefully weighed against potential harms.
C1 [Harrington, Rebecca A.; Lee, Li-Ching] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Crum, Rosa M.] Johns Hopkins Med Inst, Dept Epidemiol, Baltimore, MD 21205 USA.
[Crum, Rosa M.] Johns Hopkins Med Inst, Dept Psychiat, Baltimore, MD 21205 USA.
[Crum, Rosa M.] Johns Hopkins Med Inst, Dept Mental Hlth, Baltimore, MD 21205 USA.
[Zimmerman, Andrew W.] Univ Massachusetts, Sch Med, Dept Pediat, Worcester, MA USA.
[Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Hertz-Picciotto, Irva] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA.
RP Harrington, RA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, 615 North Wolfe St,Suite E6037, Baltimore, MD 21205 USA.
EM rharring@jhsph.edu
CR Alwan S, 2011, J CLIN PHARMACOL, V51, P264, DOI 10.1177/0091270010373928
Anderson GM, 2004, PEDIATR RES, V56, P418, DOI 10.1203/01.PDR.0000136278.23672.A0
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
Bethea CL, 1998, MOL NEUROBIOL, V18, P87, DOI 10.1007/BF02914268
Bonari L, 2004, CAN J PSYCHIAT, V49, P726
Bonnin A, 2011, NATURE, V472, P347, DOI 10.1038/nature09972
Burstyn I, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-2
Casper RC, 2011, PSYCHOPHARMACOLOGY, V217, P211, DOI 10.1007/s00213-011-2270-z
Casper RC, 2003, J PEDIATR-US, V142, P402, DOI 10.1067/mpd.203.139
COOL DR, 1990, BIOCHEM PHARMACOL, V40, P2161, DOI 10.1016/0006-2952(90)90249-K
Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73
Deave T, 2008, BJOG-INT J OBSTET GY, V115, P1043, DOI 10.1111/j.1471-0528.2008.01752.x
Dufour-Rainfray D, 2010, NEUROSCI LETT, V470, P55, DOI 10.1016/j.neulet.2009.12.054
Gentile S, 2011, J AFFECT DISORDERS, V128, P1, DOI 10.1016/j.jad.2010.02.125
Goodnick PJ, 1998, J PSYCHOPHARMACOL, V12, pS5
Harrington RA, 2013, AUTISM RES, V6, P149, DOI 10.1002/aur.1288
Hendrick V, 2003, AM J PSYCHIAT, V160, P993, DOI 10.1176/appi.ajp.160.5.993
Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
Hohmann CF, 2007, BRAIN RES, V1139, P163, DOI 10.1016/j.brainres.2006.12.095
Hviid A, 2013, NEW ENGL J MED, V369, P2406, DOI 10.1056/NEJMoa1301449
Jokiranta E, 2013, PSYCHIAT RES, V207, P203, DOI 10.1016/j.psychres.2013.01.005
LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
Larson MJ, 2007, ADM POLICY MENT HLTH, V34, P116, DOI 10.1007/s10488-006-0088-5
Lisboa SFS, 2007, PHARMACOLOGY, V80, P49, DOI 10.1159/000103097
Lord C., 2007, AUTISM DIAGNOSTIC OB
Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0
Mullen E, 1995, MULLEN SCALES EARLY
Newport DJ, 2008, BJOG-INT J OBSTET GY, V115, P681, DOI 10.1111/j.1471-0528.2008.01701.x
Pedersen LH, 2010, PEDIATRICS, V125
Preskorn SH, 2012, J PSYCHIATR PRACT, V18, P38, DOI 10.1097/01.pra.0000410986.61593.46
Rai D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2059
Rampono J, 2009, PHARMACOPSYCHIATRY, V42, P95, DOI 10.1055/s-0028-1103296
Rayen I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024003
Rice F, 2007, EARLY HUM DEV, V83, P497, DOI 10.1016/j.earlhumdev.2006.09.015
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Rothman KJ, 2008, MODERN EPIDEMIOLOGY, P128
Rurak D, 2011, PEDIATR RES, V70, P96, DOI 10.1038/pr.2011.321
Rutter M., 2005, AUTISM DIAGNOSTIC IN
Rutter M., 2003, SOCIAL COMMUNICATION
Schieve LA, 2011, ANN EPIDEMIOL, V21, P930, DOI 10.1016/j.annepidem.2011.08.009
Silva MAD, 2009, EUR NEUROPSYCHOPHARM, V19, P53, DOI 10.1016/j.euroneuro.2008.08.003
Sparrow S, 1984, VINELAND ADAPTIVE BE
Velasquez JC, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00047
Weiss LA, 2005, AM J HUM GENET, V76, P33, DOI 10.1086/426697
Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3
Whitaker-Azmitia PM, 2005, INT J DEV NEUROSCI, V23, P75, DOI 10.1016/j.ijdevneu.2004.07.022
Yonkers KA, 2009, OBSTET GYNECOL, V114, P703, DOI [10.1097/AOG.0b013e3181ba0632, 10.1016/j.genhosppsych.2009.04.003]
NR 47
TC 6
Z9 6
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2014
VL 133
IS 5
BP E1241
EP E1248
DI 10.1542/peds.2013-3406
PG 8
WC Pediatrics
SC Pediatrics
GA AG2HK
UT WOS:000335236800045
PM 24733881
ER
PT J
AU Napoli, E
Wong, S
Hertz-Picciotto, I
Giulivi, C
AF Napoli, Eleonora
Wong, Sarah
Hertz-Picciotto, Irva
Giulivi, Cecilia
TI Deficits in Bioenergetics and Impaired Immune Response in Granulocytes
From Children With Autism
SO PEDIATRICS
LA English
DT Article
DE mitochondria; autism; NFE2L2; Nrf2; oxidative stress; immune response;
bioenergetics; NADPH oxidase
ID MITOCHONDRIAL-DNA; GENE-EXPRESSION; OXIDATIVE STRESS; SPECTRUM
DISORDERS; MATERNAL INFECTION; PERIPHERAL-BLOOD; REACTIVE OXYGEN; INNATE
IMMUNITY; MESSENGER-RNA; SUPEROXIDE-DISMUTASE
AB Despite the emerging role of mitochondria in immunity, a link between bioenergetics and the immune response in autism has not been explored. Mitochondrial outcomes and phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst were evaluated in granulocytes from age-, race-, and gender-matched children with autism with severity scores of 7 (n = 10) and in typically developing (TD) children (n = 10). The oxidative phosphorylation capacity of granulocytes was 3-fold lower in children with autism than in TD children, with multiple deficits encompassing 1 Complexes. Higher oxidative stress in cells of children with autism was evidenced by higher rates of mitochondrial reactive oxygen species production (1.6-fold), higher mitochondrial DNA copy number per cell (1.5-fold), and increased deletions. Mitochondrial dysfunction in children with autism was accompanied by a lower (26% of TD children) oxidative burst by PMA-stimulated reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase and by a lower gene expression (45% of TD children's mean values) of the nuclear factor erythroid 2-related factor 2 transcription factor involved in the antioxidant response. Given that the majority of granulocytes of children with autism exhibited defects in oxidative phosphorylation, immune response, and antioxidant defense, our results support the concept that immunity and response to oxidative stress may be regulated by basic mitochondrial functions as part of an integrated metabolic network.
C1 [Napoli, Eleonora; Wong, Sarah; Giulivi, Cecilia] Univ Calif Davis, Dept Mol Biosci, Sch Vet Med, Davis, CA 95616 USA.
[Hertz-Picciotto, Irva] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Hertz-Picciotto, Irva; Giulivi, Cecilia] Univ Calif Davis, Med Invest Neurodev Disorders MIND Inst, Davis, CA 95616 USA.
RP Giulivi, C (reprint author), Univ Calif Davis, Dept Mol Biosci, 1089 Vet Med Dr,VetMed 3B, Davis, CA 95616 USA.
EM cgiulivi@ucdavis.edu
FU Simons Foundation [SFARI 271406]; NIEHS [R01-ES011269, R01-ES015359,
R01-ES020392]; National Institutes of Health (NIH)
FX This study was performed with funding from the Simons Foundation (SFARI
271406 to Dr Giulivi) and NIEHS R01-ES011269, R01-ES015359, and
R01-ES020392. Funded by the National Institutes of Health (NIH).
CR Anderson L, 1997, ELECTROPHORESIS, V18, P533, DOI 10.1002/elps.1150180333
Anitha A, 2013, BRAIN PATHOL, V23, P294, DOI 10.1111/bpa.12002
Arnoult D, 2011, EMBO REP, V12, P901, DOI 10.1038/embor.2011.157
Ashwood P, 2006, J NEUROIMMUNOL, V173, P126, DOI 10.1016/j.jneuroim.2005.12.007
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
ATTARDI G, 1995, BBA-MOL BASIS DIS, V1271, P241, DOI 10.1016/0925-4439(95)00034-2
Babior BM, 2002, ARCH BIOCHEM BIOPHYS, V397, P342, DOI 10.1006/abbi.2001.2642
Babior BM, 2000, AM J MED, V109, P33, DOI 10.1016/S0002-9343(00)00481-2
Calkins MJ, 2005, P NATL ACAD SCI USA, V102, P244, DOI 10.1073/pnas.0408487101
Carta S, 2012, ANN RHEUM DIS, V71, P1577, DOI 10.1136/annrheumdis-2012-201340
Cho HY, 2010, AM J RESP CRIT CARE, V182, P170, DOI 10.1164/rccm.200907-1047OC
Cloonan SM, 2012, CURR OPIN IMMUNOL, V24, P32, DOI 10.1016/j.coi.2011.11.001
Cole AR, 2000, ELECTROPHORESIS, V21, P1772, DOI 10.1002/(SICI)1522-2683(20000501)21:9<1772::AID-ELPS1772>3.3.CO;2-X
Connolly BS, 2010, BIOCHEM BIOPH RES CO, V402, P443, DOI 10.1016/j.bbrc.2010.10.060
Coppola G, 2008, ANN NEUROL, V64, P92, DOI 10.1002/ana.21397
Croonenberghs J, 2002, NEUROPSYCHOBIOLOGY, V45, P1, DOI 10.1159/000048665
Escartin C, 2011, J NEUROSCI, V31, P7392, DOI 10.1523/JNEUROSCI.6577-10.2011
Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011
Ginsberg MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044736
Giulivi C, 2013, MEDIAT INFLAMM, DOI 10.1155/2013/609602
Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
Glatt SJ, 2012, J AM ACAD CHILD PSY, V51, P934, DOI [10.1016/j.jaac.2012.07.007, 10.1016/j.jaac.2011.07.007]
Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
GOLSE B, 1978, REV NEUROL, V134, P699
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Graf WD, 2000, J CHILD NEUROL, V15, P357, DOI 10.1177/088307380001500601
Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
Gygi SP, 1999, MOL CELL BIOL, V19, P1720
Hadjixenofontos A, 2013, ANN HUM GENET, V77, P9, DOI 10.1111/j.1469-1809.2012.00736.x
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Ikeda Y, 2000, J BIOL CHEM, V275, P33142, DOI 10.1074/jbc.M002319200
James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
Jasinska AJ, 2009, HUM MOL GENET, V18, P4415, DOI 10.1093/hmg/ddp397
Jin YNN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057932
Johnson DA, 2010, TOXICOL SCI, V114, P237, DOI 10.1093/toxsci/kfp274
Kensler TW, 2007, ANNU REV PHARMACOL, V47, P89, DOI 10.1146/annurev.pharmtox.46.120604.141046
Kong SW, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049475
Lambeth JD, 2004, NAT REV IMMUNOL, V4, P181, DOI 10.1038/nri1312
LARDY HA, 1964, BIOCHEMISTRY-US, V3, P1961, DOI 10.1021/bi00900a030
Lee JM, 2005, FASEB J, V19, P1061, DOI 10.1096/fj.04-2591hyp
Lee JM, 2003, J BIOL CHEM, V278, P37948, DOI 10.1074/jbc.M305204200
Liu TF, 2012, J LEUKOCYTE BIOL, V92, P499, DOI 10.1189/jlb.0212078
McCall CE, 2011, J LEUKOCYTE BIOL, V90, P439, DOI 10.1189/jlb.0211075
Ming X, 2010, BRAIN DEV-JPN, V32, P105, DOI 10.1016/j.braindev.2008.12.017
Molloy CA, 2006, J NEUROIMMUNOL, V172, P198, DOI 10.1016/j.jneuroim.2005.11.007
Napoli E, 2011, HUM MOL GENET, V20, P3079, DOI 10.1093/hmg/ddr211
Napoli E, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-2
Napoli E, 2013, TOXICOL SCI, V132, P196, DOI 10.1093/toxsci/kfs339
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Padmos RC, 2008, ARCH GEN PSYCHIAT, V65, P395, DOI 10.1001/archpsyc.65.4.395
Parellada M, 2012, J PSYCHIATR RES, V46, P394, DOI 10.1016/j.jpsychires.2011.10.004
Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
Patterson PH, 2012, BRAIN BEHAV IMMUN, V26, P393, DOI 10.1016/j.bbi.2011.09.008
Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
Pickering AM, 2012, J BIOL CHEM, V287, P10021, DOI 10.1074/jbc.M111.277145
Piryaei F, 2012, CELL J, V14, P98
Ramachandran A, 2004, P NATL ACAD SCI USA, V101, P384, DOI 10.1073/pnas.0304653101
Rangasamy T, 2005, J EXP MED, V202, P47, DOI 10.1084/jem.20050538
Rushworth SA, 2005, J IMMUNOL, V175, P4408
Sasai M, 2006, J IMMUNOL, V177, P8676
Scherzer CR, 2007, P NATL ACAD SCI USA, V104, P955, DOI 10.1073/pnas.0610204104
Schwartzer JJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.16
Sena LA, 2013, IMMUNITY, V38, P225, DOI 10.1016/j.immuni.2012.10.020
Seth RB, 2006, CELL RES, V16, P141, DOI 10.1038/sj.cr.7310019
Shi HX, 2011, PLOS PATHOG, V7, DOI 10.1371/journal.ppat.1002057
Shintani Y, 2013, P NATL ACAD SCI USA, V110, P5109, DOI 10.1073/pnas.1219243110
Stack C, 2010, FREE RADICAL BIO MED, V49, P147, DOI 10.1016/j.freeradbiomed.2010.03.017
Suliman HB, 2005, FASEB J, V19, P1531, DOI 10.1096/fj.04-3500fje
Sullivan PF, 2006, AM J MED GENET B, V141B, P261, DOI 10.1002/ajmg.b.30272
Torsdottir G, 2005, BASIC CLIN PHARMACOL, V96, P146, DOI 10.1111/j.1742-7843.2005.pto960210.x
Tsuji G, 2012, J INVEST DERMATOL, V132, P59, DOI 10.1038/jid.2011.194
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Vats D, 2006, CELL METAB, V4, P13, DOI 10.1016/j.cmet.2006.05.011
Washizuka S, 2009, NEUROSCI RES, V63, P199, DOI 10.1016/j.neures.2008.12.004
Weissman JR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003815
Wolach B, 2008, CLIN IMMUNOL, V129, P103, DOI 10.1016/j.clim.2008.06.012
Zerbo O, 2013, J AUTISM DEV DISORD, V43, P25, DOI 10.1007/s10803-012-1540-x
NR 77
TC 3
Z9 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2014
VL 133
IS 5
BP E1405
EP E1410
DI 10.1542/peds.2013-1545
PG 6
WC Pediatrics
SC Pediatrics
GA AG2HK
UT WOS:000335236800069
PM 24753527
ER
PT J
AU Suren, P
Gunnes, N
Roth, C
Bresnahan, M
Hornig, M
Hirtz, D
Lie, KK
Lipkin, WI
Magnus, P
Reichborn-Kjennerud, T
Schjolberg, S
Susser, E
Oyen, AS
Smith, GD
Stoltenberg, C
AF Suren, Pal
Gunnes, Nina
Roth, Christine
Bresnahan, Michaeline
Hornig, Mady
Hirtz, Deborah
Lie, Kari Kveim
Lipkin, W. Ian
Magnus, Per
Reichborn-Kjennerud, Ted
Schjolberg, Synnve
Susser, Ezra
Oyen, Anne-Siri
Smith, George Davey
Stoltenberg, Camilla
TI Parental Obesity and Risk of Autism Spectrum Disorder
SO PEDIATRICS
LA English
DT Article
DE autism spectrum disorder; autistic disorder; Asperger disorder; PDD-NOS;
parental obesity; parental BMI; child cohort study
ID BODY-MASS INDEX; BIRTH COHORT; BIAS; PREGNANCY; DELETIONS; ORIGIN; ADHD
AB OBJECTIVES:The objective of the study was to investigate the associations among maternal prepregnancy BMI, paternal BMI, and the risk of autism spectrum disorders (ASDs) in children.METHODS:The study sample of 92909 children was derived from the population-based, prospective Norwegian Mother and Child Cohort Study. The age range was 4.0 through 13.1 (mean 7.4) years. Relative risks of ASDs were estimated by odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models.RESULTS:At the end of follow-up on December 31, 2012, 419 children in the study sample had been diagnosed with ASDs: 162 with autistic disorder, 103 with Asperger disorder, and 154 with pervasive developmental disorder not otherwise specified. Maternal obesity (BMI 30) was only weakly associated with ASD risk, whereas paternal obesity was associated with an increased risk of autistic disorder and Asperger disorder. The risk of autistic disorder was 0.27% (25 of 9267) in children of obese fathers and 0.14% (59 of 41603) in children of fathers with normal weight (BMI <25), generating an adjusted OR of 1.73 (95% CI: 1.07-2.82). For Asperger disorder, analyses were limited to children aged 7 years (n = 50116). The risk was 0.38% (18 of 4761) in children of obese fathers and 0.18% (42 of 22736) in children of normal-weight fathers, and the adjusted OR was 2.01 (95% CI: 1.13-3.57). No associations were found for pervasive developmental disorder not otherwise specified.CONCLUSIONS:Paternal obesity is an independent risk factor for ASDs in children. The associations should be investigated further in genetic and epigenetic studies.
C1 [Suren, Pal; Gunnes, Nina; Roth, Christine; Lie, Kari Kveim; Magnus, Per; Reichborn-Kjennerud, Ted; Schjolberg, Synnve; Oyen, Anne-Siri; Stoltenberg, Camilla] Norwegian Inst Publ Hlth, N-0403 Oslo, Norway.
[Suren, Pal] UCL Inst Child Hlth, Ctr Paediat Epidemiol & Biostat, London, England.
[Gunnes, Nina; Roth, Christine; Bresnahan, Michaeline; Hornig, Mady; Lipkin, W. Ian; Susser, Ezra] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA.
[Bresnahan, Michaeline; Susser, Ezra] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Hirtz, Deborah] NINDS, Bethesda, MD 20892 USA.
[Reichborn-Kjennerud, Ted] Univ Oslo, Inst Psychiat, Oslo, Norway.
[Oyen, Anne-Siri] Lovisenberg Hosp, Nic Waals Inst, Oslo, Norway.
[Smith, George Davey] Univ Bristol, MRC, Ctr Causal Anal Translat Epidemiol, Bristol, Avon, England.
[Stoltenberg, Camilla] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
RP Suren, P (reprint author), Norwegian Inst Publ Hlth, POB 4404 Nydalen, N-0403 Oslo, Norway.
EM pal.suren@fhi.no
RI Davey Smith, George/A-7407-2013
OI Davey Smith, George/0000-0002-1407-8314
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
Basatemur E, 2013, PEDIATRICS, V131, P56, DOI 10.1542/peds.2012-0788
Bochukova EG, 2010, NATURE, V463, P666, DOI 10.1038/nature08689
Brion MJ, 2011, PEDIATRICS, V127
Fradin D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012513
Greene N, 2011, EPIDEMIOLOGY, V22, P815, DOI 10.1097/EDE.0b013e31822939fd
HARRIS JR, 1995, GENET EPIDEMIOL, V12, P251, DOI 10.1002/gepi.1370120303
Heikura U, 2008, AM J EPIDEMIOL, V167, P169, DOI 10.1093/aje/kwm291
Khandaker GM, 2012, OBES REV, V13, P518, DOI 10.1111/j.1467-789X.2011.00971.x
Kong A, 2009, NATURE, V462, P868, DOI 10.1038/nature08625
Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
Lamb JA, 2005, J MED GENET, V42, P132, DOI 10.1136/jmg.2004.025668
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Magnus P, 2006, INT J EPIDEMIOL, V35, P1146, DOI 10.1093/ije/dyl170
BLAND JM, 1986, LANCET, V1, P307
Ng SF, 2010, NATURE, V467, P963, DOI 10.1038/nature09491
Nilsen RM, 2009, PAEDIATR PERINAT EP, V23, P597, DOI 10.1111/j.1365-3016.2009.01062.x
Nilsen RM, 2013, PAEDIATR PERINAT EP, V27, P553, DOI 10.1111/ppe.12077
Nohr EA, 2006, EPIDEMIOLOGY, V17, P413, DOI 10.1097/01.ede.0000220549.14177.60
Relton CL, 2012, INT J EPIDEMIOL, V41, P5, DOI 10.1093/ije/dys006
Rodriguez A, 2008, INT J OBESITY, V32, P550, DOI 10.1038/sj.ijo.0803741
Soubry A, INT J OBESITY
Stoltenberg C, 2010, MOL PSYCHIATR, V15, P676, DOI 10.1038/mp.2009.143
Suren P, 2012, PEDIATRICS, V130, pE152, DOI 10.1542/peds.2011-3217
Walters RG, 2010, NATURE, V463, P671, DOI 10.1038/nature08727
WHO, GLOB DAT BOD MASS IN
Wolke D, 2009, BRIT J PSYCHIAT, V195, P249, DOI 10.1192/bjp.bp.108.053751
NR 31
TC 3
Z9 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2014
VL 133
IS 5
BP E1128
EP E1138
DI 10.1542/peds.2013-3664
PG 11
WC Pediatrics
SC Pediatrics
GA AG2HK
UT WOS:000335236800031
PM 24709932
ER
PT J
AU Morita, T
Tanabe, HC
Sasaki, AT
Shimada, K
Kakigi, R
Sadato, N
AF Morita, Tomoyo
Tanabe, Hiroki C.
Sasaki, Akihiro T.
Shimada, Koji
Kakigi, Ryusuke
Sadato, Norihiro
TI The anterior insular and anterior cingulate cortices in emotional
processing for self-face recognition
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE anterior cingulate cortex; anterior insular cortex; embarrassment;
functional magnetic resonance imaging; self-evaluation of the face
ID EVENT-RELATED FMRI; AUTISM SPECTRUM DISORDERS; MEDIAL PREFRONTAL CORTEX;
AUTOBIOGRAPHICAL MEMORY; FUNCTIONAL NEUROANATOMY; SOCIAL COGNITION;
NEURAL BASIS; OWN FACE; ACTIVATION; TIME
AB Individuals can experience embarrassment when exposed to self-feedback images, depending on the extent of the divergence from the internal representation of the standard self. Our previous work implicated the anterior insular cortex (AI) and the anterior cingulate cortex (ACC) in the processing of embarrassment; however, their exact functional contributions have remained uncertain. Here, we explored the effects of being observed by others while viewing self-face images on the extent of embarrassment, and the activation and connectivity patterns in the AI and ACC. We conducted functional magnetic resonance imaging hyperscanning in pairs of healthy participants using an interaction system that allowed an individual to be observed by a partner in real time. Being observed increased the extent of embarrassment reported when viewing self-face images; a corresponding increase in self-related activity in the right AI suggested that this region played a direct role in the subjective experience. Being observed also increased the functional connectivity between the caudal ACC and prefrontal regions, which are involved in processing the reflective self. The ACC might therefore serve as a hub, integrating information about the reflective self that is used in evaluating perceptual self-face images.
C1 [Morita, Tomoyo; Kakigi, Ryusuke] Natl Inst Physiol Sci, Dept Integrat Physiol, Okazaki, Aichi 4448585, Japan.
[Tanabe, Hiroki C.; Sasaki, Akihiro T.; Shimada, Koji; Sadato, Norihiro] Natl Inst Physiol Sci, Dept Cerebral Res, Okazaki, Aichi 4448585, Japan.
[Tanabe, Hiroki C.] Nagoya Univ, Grad Sch Environm Studies, Chikusa Ku, Nagoya, Aichi 4648601, Japan.
[Shimada, Koji; Sadato, Norihiro] Grad Univ Adv Studies Sokendai, Sch Life Sci, Dept Physiol Sci, Okazaki, Aichi 4448585, Japan.
[Sadato, Norihiro] Univ Fukui, Biomed Imaging Res Ctr, Fukui 9101193, Japan.
RP Sadato, N (reprint author), Natl Inst Physiol Sci, Dept Cerebral Res, Div Cerebral Integrat, 38 Nishigo Naka, Okazaki, Aichi 4448585, Japan.
EM sadato@nips.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology (MEXT),
Japan [20119001, 23119725, 22101007]; Japan Society for the Promotion of
Science [S21220005]
FX The authors thank T. Kochiyama for advice on fMRI data analysis, and D.
Matsuyoshi and the staff of the National Institute for Physiological
Sciences for support. This work was supported by Research Fellowships
from the Ministry of Education, Culture, Sports, Science, and Technology
(MEXT), Japan [20119001 to R. K., 23119725 to T. M. and 22101007 to H.
C. T.] and by a Grant-in-Aid for Scientific Research from the Japan
Society for the Promotion of Science [S21220005 to N.S.]. Part of this
study was the result of the project 'Development of biomarker candidates
for social behavior' carried out under the Strategic Research Program
for Brain Sciences by MEXT.
CR Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
Bartels A, 2004, NEUROIMAGE, V21, P1155, DOI 10.1016/j.neuroimage.2003.11.003
Bateson M, 2006, BIOL LETT-UK, V2, P412, DOI 10.1098/rsbl.2006.0509
Benabou R, 2006, AM ECON REV, V96, P1652, DOI 10.1257/aer.96.5.1652
Blood AJ, 2001, P NATL ACAD SCI USA, V98, P11818, DOI 10.1073/pnas.191355898
Buss AH, 1980, SELF CONSCIOUSNESS S
Carver C. S., 1981, ATTENTION SELF REGUL
Carver CS, 1998, SELF REGULATION BEHA
Coull JT, 2004, COGNITIVE BRAIN RES, V21, P216, DOI 10.1016/j.cogbrainres.2004.02.011
Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
Craig AD, 2000, NAT NEUROSCI, V3, P184, DOI 10.1038/72131
Dale AM, 1999, HUM BRAIN MAPP, V8, P109, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<109::AID-HBM7>3.0.CO;2-W
D'Argembeau A, 2007, J COGNITIVE NEUROSCI, V19, P935, DOI 10.1162/jocn.2007.19.6.935
Deary IJ, 2004, NEUROIMAGE, V22, P1466, DOI 10.1016/j.neuroimage.2004.03.047
Devue C, 2007, BRAIN RES, V1143, P169, DOI 10.1016/j.brainres.2007.01.055
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Duval TS, 1972, THEORY OBJECTIVE SEL
Eisenberger NI, 2003, SCIENCE, V302, P290, DOI 10.1126/science.1089134
Evans A. C., 1994, MAGNETIC RESONANCE S
Farrer C, 2002, NEUROIMAGE, V15, P596, DOI 10.1006/nimg.2001.1009
FENIGSTEIN A, 1975, J CONSULT CLIN PSYCH, V43, P522, DOI 10.1037/h0076760
Fink GR, 1996, J NEUROSCI, V16, P4275
Fossati P, 2003, AM J PSYCHIAT, V160, P1938, DOI 10.1176/appi.ajp.160.11.1938
Friston KJ, 2002, NEUROIMAGE, V16, P465, DOI 10.1006/nimg.2002.1090
Friston KJ, 1999, NEUROIMAGE, V10, P607, DOI 10.1006/nimg.1999.0498
Friston KJ, 1997, NEUROIMAGE, V6, P218, DOI 10.1006/nimg.1997.0291
FRISTON KJ, 1995, NEUROIMAGE, V2, P45, DOI 10.1006/nimg.1995.1007
Frith CD, 2006, NEURON, V50, P531, DOI 10.1016/j.neuron.2006.05.001
Frith CD, 2008, NEURON, V60, P503, DOI 10.1016/j.neuron.2008.10.032
Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
Gallagher S, 2000, TRENDS COGN SCI, V4, P14, DOI 10.1016/S1364-6613(99)01417-5
Gitelman DR, 2003, NEUROIMAGE, V19, P200, DOI 10.1016/S1053-8119(03)00058-2
Gobbini MI, 2004, NEUROIMAGE, V22, P1628, DOI 10.1016/j.neuroimage.2004.03.049
Gusnard DA, 2001, P NATL ACAD SCI USA, V98, P4259, DOI 10.1073/pnas.071043098
Haley KJ, 2005, EVOL HUM BEHAV, V26, P245, DOI 10.1016/j.evolhumbehav.2005.01.002
Izuma K, 2008, NEURON, V58, P284, DOI 10.1016/j.neuron.2008.03.020
Izuma K, 2010, SOC NEUROSCI-UK, V5, P133, DOI 10.1080/17470910903202559
Kelley WM, 2002, J COGNITIVE NEUROSCI, V14, P785, DOI 10.1162/08989290260138672
King-Casas B, 2005, SCIENCE, V308, P78, DOI 10.1126/science.1108062
Kircher TTJ, 2000, COGNITIVE BRAIN RES, V10, P133, DOI 10.1016/S0926-6410(00)00036-7
Kircher TTJ, 2001, COGNITION, V78, pB1, DOI 10.1016/S0010-0277(00)00104-9
Kosaka H, 2010, NEUROIMAGE, V50, P1357, DOI 10.1016/j.neuroimage.2010.01.085
Livesey AC, 2007, NEUROPSYCHOLOGIA, V45, P321, DOI 10.1016/j.neuropsychologia.2006.06.033
Lou HC, 2004, P NATL ACAD SCI USA, V101, P6827, DOI 10.1073/pnas.0400049101
Maguire EA, 2003, BRAIN, V126, P1511, DOI 10.1093/brain/awg157
McGuire PK, 1996, BRAIN, V119, P907, DOI 10.1093/brain/119.3.907
Menon V, 2010, BRAIN STRUCT FUNCT, V214, P655, DOI 10.1007/s00429-010-0262-0
Modinos G, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004618
Montague PR, 2002, NEUROIMAGE, V16, P1159, DOI 10.1006/nimg.2002.1150
Moor BG, 2012, NEUROIMAGE, V59, P708, DOI 10.1016/j.neuroimage.2011.07.028
Morin A, 2007, BRAIN RES BULL, V74, P387, DOI 10.1016/j.brainresbull.2007.06.013
Morita T, 2012, SOC NEUROSCI-UK, V7, P223, DOI 10.1080/17470919.2011.598945
Morita T, 2008, J COGNITIVE NEUROSCI, V20, P342, DOI 10.1162/jocn.2008.20024
Ochsner KN, 2005, NEUROIMAGE, V28, P797, DOI 10.1016/j.neuroimage.2005.06.069
Ochsner KN, 2004, J COGNITIVE NEUROSCI, V16, P1746, DOI 10.1162/0898929042947829
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Onoda K, 2010, SOC COGN AFFECT NEUR, V5, P385, DOI 10.1093/scan/nsq002
Piolino P, 2004, NEUROIMAGE, V22, P1371, DOI 10.1016/j.neuroimage.2004.02.025
Platek SM, 2004, COGNITIVE BRAIN RES, V19, P114, DOI 10.1016/j.cogbrainres.2003.11.014
Platek SM, 2008, BRAIN RES, V1232, P173, DOI 10.1016/j.brainres.2008.07.010
Platek SM, 2006, HUM BRAIN MAPP, V27, P91, DOI 10.1002/hbm.20168
Saito Daisuke N, 2010, Front Integr Neurosci, V4, P127, DOI 10.3389/fnint.2010.00127
Seeley WW, 2007, J NEUROSCI, V27, P2349, DOI 10.1523/JNEUROSCI.5587-06.2007
SUGAWARA K, 1984, JPN J PSYCHOL, V55, P184
Sugiura M, 2000, NEUROIMAGE, V11, P36, DOI 10.1006/nimg.1999.0519
Sugiura M, 2005, NEUROIMAGE, V24, P143, DOI 10.1016/j.neuroimage.2004.07.063
Sugiura M, 2006, NEUROIMAGE, V32, P1905, DOI 10.1016/j.neuroimage.2006.05.026
Sugiura M, 2012, HUM BRAIN MAPP, V33, P1364, DOI 10.1002/hbm.21290
Takahashi H, 2008, CEREB CORTEX, V18, P898, DOI 10.1093/cercor/bhm120
Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002
Uddin LQ, 2005, NEUROIMAGE, V25, P926, DOI 10.1016/j.neuroimage.2004.12.018
Vogeley K, 2001, NEUROIMAGE, V14, P170, DOI 10.1006/nimg.2001.0789
Wicker B, 2003, NEURON, V40, P655, DOI 10.1016/S0896-6273(03)00679-2
WORSLEY KJ, 1995, NEUROIMAGE, V2, P173, DOI 10.1006/nimg.1995.1023
Worsley KJ, 1996, HUM BRAIN MAPP, V4, P58, DOI 10.1002/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O
Zaki J, 2007, SOC NEUROSCI-UK, V2, P276, DOI 10.1080/17470910701401973
NR 76
TC 3
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD MAY
PY 2014
VL 9
IS 5
BP 570
EP 579
DI 10.1093/scan/nst011
PG 10
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AH9UK
UT WOS:000336489000002
PM 23377900
ER
PT J
AU Gossen, A
Groppe, SE
Winkler, L
Kohls, G
Herrington, J
Schultz, RT
Grunder, G
Spreckelmeyer, KN
AF Gossen, Anna
Groppe, Sarah E.
Winkler, Lina
Kohls, Gregor
Herrington, John
Schultz, Robert T.
Gruender, Gerhard
Spreckelmeyer, Katja N.
TI Neural evidence for an association between social proficiency and
sensitivity to social reward
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE NAcc; social interest; empathy; social reward; autism
ID EVENT-RELATED FMRI; AUTISM SPECTRUM DISORDERS; INFANT JOINT ATTENTION;
EMPATHY QUOTIENT; IDENTITY RECOGNITION; FUNCTIONING AUTISM;
ASPERGER-SYNDROME; MONETARY REWARD; SKILLS BATTERY; ANTICIPATION
AB Data from developmental psychology suggests a link between the growth of socio-emotional competences and the infant's sensitivity to the salience of social stimuli. The aim of the present study was to find evidence for this relationship in healthy adults. Thirty-five participants were recruited based on their score above the 85th or below the 15th percentile of the empathy quotient questionnaire (EQ, Baron-Cohen and Wheelwright, 2004). Functional magnetic resonance imaging (fMRI) was used to compare neural responses to cues of social and non-social (monetary) reward. When compared to the high-EQ group, the low-EQ group showed reduced activity of the brain s reward system, specifically the right nucleus accumbens, in response to cues predictive of social reward (videos showing gestures of approval)-but increased activation in this area for monetary incentives. Our data provide evidence for a link between self-reported deficits in social proficiency and reduced sensitivity to the motivational salience of positive social stimuli.
C1 [Gossen, Anna; Groppe, Sarah E.; Winkler, Lina; Gruender, Gerhard; Spreckelmeyer, Katja N.] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Fac Med, D-52074 Aachen, Germany.
[Gossen, Anna; Groppe, Sarah E.; Winkler, Lina; Gruender, Gerhard; Spreckelmeyer, Katja N.] JARA Translat Brain Med, Aachen, Nordrhein Westf, Germany.
[Gossen, Anna; Groppe, Sarah E.; Winkler, Lina; Gruender, Gerhard; Spreckelmeyer, Katja N.] JARA Translat Brain Med, Julich, Nordrhein Westf, Germany.
[Kohls, Gregor; Herrington, John; Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Spreckelmeyer, Katja N.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
RP Gossen, A (reprint author), Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Pauwelsstr 30, D-52074 Aachen, Germany.
EM angossen@ukaachen.de
FU German Research Foundation (Deutsche Forschungsgemeinschaft) [IRTG
1328]; RWTH Aachen medical faculty funding program START; National
Institutes of Health [P30HD026979]; Robert Wood Johnson Foundation
[66727]
FX This study was supported by the German Research Foundation (Deutsche
Forschungsgemeinschaft, IRTG 1328), RWTH Aachen medical faculty funding
program START (K.N.S., L. W., S. G.), the National Institutes of Health
(P30HD026979) ( R. T. S., G. K.) and the Robert Wood Johnson Foundation
#66727 (R.T.S.).
CR Aharon I, 2001, NEURON, V32, P537, DOI 10.1016/S0896-6273(01)00491-3
Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
Banissy MJ, 2011, J NEUROSCI, V31, P1820, DOI 10.1523/JNEUROSCI.5759-09.2011
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Barton JJS, 2007, NEUROLOGY, V69, P860, DOI 10.1212/01.wnl.0000267842.85646.f2
Berthoz S, 2008, CAN J PSYCHIAT, V53, P469
Chakrabarti B, 2006, SOC NEUROSCI-UK, V1, P364, DOI 10.1080/17470910601041317
Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
Clithero JA, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00087
Cloninger C. R., 1994, TEMPERAMENT CHARACTE
Davis M. H., 1994, EMPATHY SOCIAL PSYCH
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Dawson G, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-11
Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
Decety Jean, 2004, Behav Cogn Neurosci Rev, V3, P71, DOI 10.1177/1534582304267187
DEUTSCH F, 1975, HUM DEV, V18, P267
Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
Downey G, 1996, J PERS SOC PSYCHOL, V70, P1327, DOI 10.1037//0022-3514.70.6.1327
Elsabbagh M, 2012, CURR BIOL, V22, P338, DOI 10.1016/j.cub.2011.12.056
Friston KJ, 1994, HUMAN BRAIN MAPPING, V2, P189, DOI DOI 10.1002/HBM.460020402
Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Josephs O, 1997, HUM BRAIN MAPP, V5, P243, DOI 10.1002/(SICI)1097-0193(1997)5:4<243::AID-HBM7>3.0.CO;2-3
Kim H, 2007, P NATL ACAD SCI USA, V104, P18253, DOI 10.1073/pnas.0703101104
Kim J, 2010, PSYCHIAT INVEST, V7, P24, DOI 10.4306/pi.2010.7.1.24
Kirsch P, 2003, NEUROIMAGE, V20, P1086, DOI 10.1016/S1053-8119(03)00381-1
Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
Knutson B, 2003, NEUROIMAGE, V18, P263, DOI 10.1016/S1053-8119(02)00057-5
Knutson B, 2001, NEUROREPORT, V12, P3683, DOI 10.1097/00001756-200112040-00016
Knutson B, 2001, J Neurosci, V21, pRC159
Knutson B, 2008, PHILOS T R SOC B, V363, P3771, DOI 10.1098/rstb.2008.0155
Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1
Kohls G, 2013, SOC COGN AFFECT NEUR, V8, P565, DOI 10.1093/scan/nss033
Kohls G, 2009, DEVELOPMENTAL SCI, V12, P614, DOI 10.1111/j.1467-7687.2009.00816.x
Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
Lin A, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00143
Lubben J., 2004, SOCIAL NETWORKS SOCI, P20
Maldjian JA, 2003, NEUROIMAGE, V19, P1233, DOI 10.1016/S1053-8119(03)00169-1
Mundy P, 2010, NEURAL NETWORKS, V23, P985, DOI 10.1016/j.neunet.2010.08.009
Mundy P, 2001, INT REV RES MENT RET, V23, P139
O'Doherty JP, 2002, NEURON, V33, P815, DOI 10.1016/S0896-6273(02)00603-7
O'Doherty JP, 2006, NEURON, V49, P157, DOI 10.1016/j.neuron.2005.11.014
Parlade MV, 2009, INFANT BEHAV DEV, V32, P33, DOI 10.1016/j.infbeh.2008.09.007
Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
Rademacher L, 2010, NEUROIMAGE, V49, P3276, DOI 10.1016/j.neuroimage.2009.10.089
Schneider D, 2012, PSYCHIAT RES, V200, P294, DOI 10.1016/j.psychres.2012.03.054
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
Sims TB, 2012, PSYCHOPHYSIOLOGY, V49, P998, DOI 10.1111/j.1469-8986.2012.01377.x
Spreckelmeyer KN, 2009, SOC COGN AFFECT NEUR, V4, P158, DOI 10.1093/scan/nsn051
Spreckelmeyer K.N., 2012, NEUROIMAGE C, V66C, P223
Staebler K., 2010, CLIN PSYCHOL PSYCHOT, V18, P275, DOI 10.1002/cpp.705
Strathearn L, 2009, NEUROPSYCHOPHARMACOL, V34, P2655, DOI 10.1038/npp.2009.103
Tanaka JW, 2012, J CHILD PSYCHOL PSYC, V53, P1259, DOI 10.1111/j.1469-7610.2012.02571.x
Thut G, 1997, NEUROREPORT, V8, P1225, DOI 10.1097/00001756-199703240-00033
Triesch J, 2006, DEVELOPMENTAL SCI, V9, P125, DOI 10.1111/j.1467-7687.2006.00470.x
Van Hecke AV, 2007, CHILD DEV, V78, P53
Van Overwalle F, 2009, NEUROIMAGE, V48, P564, DOI 10.1016/j.neuroimage.2009.06.009
Von Horn A, 2010, SCAND J PSYCHOL, V51, P31, DOI 10.1111/j.1467-9450.2009.00725.x
Wakabayashi A, 2007, J AUTISM DEV DISORD, V37, P1823, DOI 10.1007/s10803-006-0316-6
Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
Wiseman T, 1996, J ADV NURS, V23, P1162, DOI 10.1046/j.1365-2648.1996.12213.x
Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
NR 68
TC 2
Z9 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD MAY
PY 2014
VL 9
IS 5
BP 661
EP 670
DI 10.1093/scan/nst033
PG 10
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AH9UK
UT WOS:000336489000013
PM 23512930
ER
PT J
AU Thomas, GM
AF Thomas, Gareth M.
TI Cooling the Mother Out: Revisiting and Revising Goffman's Account
SO SYMBOLIC INTERACTION
LA English
DT Article
DE mothers; cooling the mark out; stigma; Goffman; disability
ID DOWN-SYNDROME; CHILDREN; STIGMA; DISABILITIES; FAMILIES; IDENTITY;
FAILURE; PARENTS; AUTISM
AB This article revisits Erving Goffman's important yet neglected metaphor of "cooling the mark out." Drawing on a study of mothers whose child has Down's syndrome, I explore the value of Goffman's work for capturing how mothers interpret their child's diagnosis as a loss and rectify this breach by constructing an acceptance of their new situation. The mothers' accounts highlight how Goffman's contentions can be enriched by acknowledging the gendered, temporal, and public character of a loss. This article, thus, can be read both as a celebration and critical revision of his theoretical contribution.
C1 Cardiff Univ, Sch Social Sci, Cardiff CF10 3BD, S Glam, Wales.
RP Thomas, GM (reprint author), Cardiff Univ, Sch Social Sci, 1-3 Museum Pl,Second Floor, Cardiff CF10 3BD, S Glam, Wales.
EM thomasg23@cf.ac.uk
CR Akerstrom M, 1997, QUAL HEALTH RES, V7, P504, DOI 10.1177/104973239700700405
Atkinson P, 2003, INTERACTIONISM
BALL DW, 1976, AM SOCIOL REV, V41, P726, DOI 10.2307/2094846
Becker Howard S., 1956, AM J SOCIOL, V62, P252
Canguilhem Georges, 2005, BODY READER, P187
Charmaz K., 1991, GOOD DAYS BAD DAYS S
CLARK BR, 1960, AM J SOCIOL, V65, P569, DOI 10.1086/222787
Clark Bernard, 2008, MOTHER ALEX
Clarke AE, 2003, SYMB INTERACT, V26, P553, DOI 10.1525/si.2003.26.4.553
Fields J, 2001, SYMB INTERACT, V24, P165, DOI 10.1525/si.2001.24.2.165
Goffman E, 1963, STIGMA NOTES MANAGEM
Goffman E, 1959, PRESENTATION SELF EV
Goffman E., 1961, ASYLUMS ESSAYS SOCIA
Goffman E, 1952, PSYCHIATR, V15, P451
Goffman E, 1974, FRAME ANAL ESSAY ORG
Gray DE, 2002, SOCIOL HEALTH ILL, V24, P734, DOI 10.1111/1467-9566.00316
Green SE, 2003, SOC SCI MED, V57, P1361, DOI 10.1016/S0277-9536(02)00511-7
Hodapp RM, 2007, MENT RETARD DEV D R, V13, P279, DOI 10.1002/mrdd.20160
Landsman Gail, 1999, TRANSFORMATIVE MOTHE, P133
Lewis Sandy, 2008, LIVING MAX
Makitalo SA, 2006, SYMB INTERACT, V29, P531
McCorkel Jill A., 2003, QUALITATIVE SOCIOLOG, V26, P199, DOI DOI 10.1023/A:1022967012774
Morris Joan K., 2013, NATL SYNDROME CYTOGE
Paolucci P, 2006, SYMB INTERACT, V29, P331, DOI 10.1525/si.2006.29.3.331
PETRUNIK MG, 1972, J VOLUNT ACTION RES, V1, P30
Rapp R, 1995, NATURALIZING POWER, P69
Rapp Rayna, 1999, TRANSFORMATIVE MOTHE, pxi
Rocque B, 2010, DISABIL SOC, V25, P485, DOI 10.1080/09687591003755864
SCAMBLER G, 1986, SOCIOL HEALTH ILL, V8, P26, DOI 10.1111/1467-9566.ep11346455
Simmel Georg, 1950, SOCIOLOGY G SIMMEL
Skotko B, 2005, PEDIATRICS, V115, P64, DOI 10.1542/peds.2004-0928
Smith RJ, 2011, SYMB INTERACT, V34, P357, DOI 10.1525/si.2011.34.3.357
SNOW DA, 1991, J CONTEMP ETHNOGR, V19, P423, DOI 10.1177/089124191019004003
Sousa AC, 2011, SYMB INTERACT, V34, P220, DOI 10.1525/si.2011.34.2.220
Strong Philip M., 1979, CEREMONIAL ORDER CLI
Thomas Gareth M., 2012, QUALITATIVE RES, V14, P6
Thompson AI, 2013, SYMB INTERACT, V36, P21, DOI 10.1002/symb.50
Voysey Margaret, 1975, CONSTANT BURDEN RECO
NR 38
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0195-6086
EI 1533-8665
J9 SYMB INTERACT
JI Symb. Interact.
PD MAY
PY 2014
VL 37
IS 2
BP 283
EP 299
DI 10.1002/symb.91
PG 17
WC Sociology
SC Sociology
GA AG8CX
UT WOS:000335647500008
ER
PT J
AU Hu, X
Gan, SQ
Xie, GE
Li, L
Chen, C
Ding, XF
Han, M
Xiang, SL
Zhang, J
AF Hu, Xiang
Gan, Shiquan
Xie, Guie
Li, Li
Chen, Cheng
Ding, Xiaofeng
Han, Mei
Xiang, Shuanglin
Zhang, Jian
TI KCTD10 is critical for heart and blood vessel development of zebrafish
SO ACTA BIOCHIMICA ET BIOPHYSICA SINICA
LA English
DT Article
DE KCTD10; PDIP1; heart; blood vessel; zebrafish
ID CELL NUCLEAR ANTIGEN; PROTEIN; GENES; EXPRESSION; TETRAMERIZATION;
PROLIFERATION; HEMATOPOIESIS; EVOLUTION; INTERACTS; DOMAIN
AB KCTD10 is a member of the PDIP1 family, which is highly conserved during evolution, sharing a lot of similarities among human, mouse, and zebrafish. Recently, zebrafish KCTD13 has been identified to play an important role in the early development of brain and autism. However, the specific function of KCTD10 remains to be elucidated. In this study, experiments were carried out to determine the expression pattern of zebrafish KCTD10 mRNA during embryonic development. It was found that KCTD10 is a maternal gene and KCTD10 is of great importance in the shaping of heart and blood vessels. Our data provide direct clues that knockdown of KCTD10 resulted in severe pericardial edema and loss of heart formation indicated by morphological observation and crucial heart markers like amhc, vmhc, and cmlc2. The heart defect caused by KCTD10 is linked to RhoA and PCNA. Flk-1 staining revealed that intersomitic vessels were lost in the trunk, although angioblasts could migrate to the midline. These findings could be helpful to better understand the determinants responsible for the heart and blood vessel defects.
C1 [Hu, Xiang; Gan, Shiquan; Xie, Guie; Li, Li; Chen, Cheng; Ding, Xiaofeng; Han, Mei; Xiang, Shuanglin; Zhang, Jian] Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, State Educ Minist China, Changsha 410081, Hunan, Peoples R China.
[Zhang, Jian] Shanghai Jiao Tong Univ, E Inst Shanghai Univ, Model Organism Div, Shanghai 200240, Peoples R China.
RP Xiang, SL (reprint author), Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, State Educ Minist China, Changsha 410081, Hunan, Peoples R China.
EM xshlin@hunnu.edu.cn; zhangjian@hunnu.edu.cn
FU Ministry of Science and Technique of China [2010CB529900]; E-Institutes
of Shanghai Municipal Education Commission [E03003]; Science &
Technology Department of Hunan Province [13JJ6037]; Hunan Postdoctoral
Science Foundation [2012RS4016]
FX This study was supported by the grants from the Ministry of Science and
Technique of China (No. 2010CB529900), the E-Institutes of Shanghai
Municipal Education Commission (No. E03003), the Science & Technology
Department of Hunan Province (13JJ6037), and the Hunan Postdoctoral
Science Foundation (2012RS4016).
CR Aravind L, 1999, J MOL BIOL, V285, P1353, DOI 10.1006/jmbi.1998.2394
Berdougo E, 2003, DEVELOPMENT, V130, P6121, DOI 10.1242/dev.00838
Bixby KA, 1999, NAT STRUCT BIOL, V6, P38
Cheng L, 2006, BIOCHEM BIOPH RES CO, V344, P1290, DOI 10.1016/j.bbrc.2006.03.234
Chocron S, 2007, DEV BIOL, V305, P577, DOI 10.1016/j.ydbio.2007.03.001
Fujii T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023491
Genschik P, 2013, EMBO J, V32, P2307, DOI 10.1038/emboj.2013.173
Glickman NS, 2002, SEMIN CELL DEV BIOL, V13, P507, DOI 10.1016/S1084-9521(02)00104-0
Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
Grimes AC, 2009, J FISH BIOL, V74, P983, DOI 10.1111/j.1095-8649.2008.02125.x
Jopling C, 2010, NATURE, V464, P606, DOI 10.1038/nature08899
Kaarbo M, 2013, SCI WORLD J, DOI 10.1155/2013/491546
Kim DM, 2009, INT J CANCER, V125, P2520, DOI 10.1002/ijc.24617
KIMMEL CB, 1995, DEV DYNAM, V203, P253
Leung AYH, 2005, HISTOCHEM CELL BIOL, V124, P105, DOI 10.1007/s00418-005-0003-2
Liang D, 2001, MECH DEVELOP, V108, P29, DOI 10.1016/S0925-4773(01)00468-3
Liu R, 2009, FEBS J, V276, P1114, DOI 10.1111/j.1742-4658.2008.06855.x
Moeller H, 2006, P NATL ACAD SCI USA, V103, P15900, DOI 10.1073/pnas.0603808103
Moorman AFM, 2003, PHYSIOL REV, V83, P1223, DOI 10.1152/physrev.00006.2003
Nasevicius A, 2000, NAT GENET, V26, P216, DOI 10.1038/79951
Pintard L, 2003, NATURE, V425, P311, DOI 10.1038/nature01959
Skoblov M, 2013, BIOESSAYS, V35, P586, DOI 10.1002/bies.201300002
Stainier DYR, 2001, NAT REV GENET, V2, P39, DOI 10.1038/35047564
Staudt D, 2012, ANNU REV GENET, V46, P397, DOI 10.1146/annurev-genet-110711-155646
Stogios PJ, 2005, GENOME BIOL, V6, DOI 10.1186/gb-2005-6-10-r82
Wang YB, 2009, J CELL BIOCHEM, V106, P409, DOI 10.1002/jcb.22026
Yang Li-Ping, 2006, Yichuan, V28, P918
Yelon D, 1999, DEV BIOL, V214, P23, DOI 10.1006/dbio.1999.9406
Zhong TP, 2001, NATURE, V414, P216, DOI 10.1038/35102599
Zhou JL, 2005, BBA-GENE STRUCT EXPR, V1729, P200, DOI 10.1016/j.bbaexp.2005.05.005
Zhou JL, 2005, J EXP ZOOL PART A, V303A, P227, DOI 10.1002/jez.a.150
NR 31
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1672-9145
EI 1745-7270
J9 ACTA BIOCH BIOPH SIN
JI Acta Biochim. Biophys. Sin.
PD MAY
PY 2014
VL 46
IS 5
BP 377
EP 386
DI 10.1093/abbs/gmu017
PG 10
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AG9VT
UT WOS:000335768700004
PM 24705121
ER
PT J
AU Samyn, V
Wiersema, JR
Bijttebier, P
Roeyers, H
AF Samyn, Vicky
Wiersema, Jan R.
Bijttebier, Patricia
Roeyers, Herbert
TI Effortful control and executive attention in typical and atypical
development: An event-related potential study
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Executive attention; Flanker task; ERP; ERN; Effortful control; ADHD;
Autism spectrum disorder
ID DEFICIT HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDER; ANTERIOR
CINGULATE CORTEX; ERROR-RELATED-NEGATIVITY; DEFICIT/HYPERACTIVITY
DISORDER; RESPONSE-INHIBITION; INDIVIDUAL-DIFFERENCES; SOURCE
LOCALIZATION; SELF-REGULATION; FUNCTIONAL-SIGNIFICANCE
AB Executive attention and its relationship with effortful control (EC) were investigated in children with ADHD (n = 24), autism spectrum disorder (ASD; n = 20), and controls (n = 21). Executive attention measures included flanker-performance and event-related potentials (N2, P3, and ERN). EC was assessed using questionnaires. Only the ERN was found to be robustly related to EC across groups. N2 did not differ between groups and only children with ADHD + ODD showed diminished executive attention as expressed in RT and P3. In ADHD, monitoring of incorrect (ERN) and correct (CRN) responses was diminished. Overall, the link between EC and executive attention was less strong as expected and varied depending on group and measure considered. All groups were able to detect conflict (N2) and all but ADHD + ODD were able to allocate extra attention in order to respond correctly (P3). Findings indicate a general reduced response monitoring in ADHD. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Samyn, Vicky; Wiersema, Jan R.; Roeyers, Herbert] Univ Ghent, B-9000 Ghent, Belgium.
[Bijttebier, Patricia] Univ Louvain, B-3000 Louvain, Belgium.
RP Wiersema, JR (reprint author), Univ Ghent, Henri Dunantlaan 2, B-9000 Ghent, Belgium.
EM vicky_samyn@hotmail.com; Roeljan.Wiersema@UGent.be;
Patricia.Bijttebier@ppw.kuleuven.be; Herbert.Roeyers@UGent.be
FU faculty of Psychology and Educational Sciences of the Ghent University
FX The first author received funding from the research fund of the faculty
of Psychology and Educational Sciences of the Ghent University. The
funding source had no further involvement.
CR Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3
Adolfsdottir S, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-9
Albrecht B, 2008, BIOL PSYCHIAT, V64, P615, DOI 10.1016/j.biopsych.2007.12.016
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Banaschewski T, 2005, DEVELOPMENTAL SCI, V8, P132, DOI 10.1111/j.1467-7687.2005.00400.x
Banaschewski T., 2003, J CHILD PSYCHOL PSYC, V43, P1
Barkley RA, 1998, SCI AM, V279, P66
Bekker EM, 2005, COGNITIVE BRAIN RES, V22, P221, DOI 10.1016/j.cogbrainres.2004.08.011
Berger A, 2000, NEUROSCI BIOBEHAV R, V24, P3, DOI 10.1016/S0149-7634(99)00046-9
Bokura H, 2001, CLIN NEUROPHYSIOL, V112, P2224, DOI 10.1016/S1388-2457(01)00691-5
Booth JE, 2007, ARCH CLIN NEUROPSYCH, V22, P423, DOI 10.1016/j.acn.2007.01.017
BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535
Bush G, 1999, BIOL PSYCHIAT, V45, P1542, DOI 10.1016/S0006-3223(99)00083-9
Bush G, 2000, TRENDS COGN SCI, V4, P215, DOI 10.1016/S1364-6613(00)01483-2
Buss KA, 2011, DEV COGN NEUROS-NETH, V1, P131, DOI 10.1016/j.dcn.2010.12.003
Chan AS, 2011, RES AUTISM SPECT DIS, V5, P254, DOI 10.1016/j.rasd.2010.04.007
Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Constantino JN, 2005, SOCIAL RESPONSIVENES
Derryberry D, 2002, J ABNORM PSYCHOL, V111, P225, DOI 10.1037//0021-843X.111.2.225
Doyle-Thomas KAR, 2013, J CHILD NEUROL, V28, P729, DOI 10.1177/0883073812451496
Ellis L. K., 2001, 2001 BIENN M SOC RES
Ellis LK, 2004, ANN NY ACAD SCI, V1021, P337, DOI 10.1196/annals.1308.041
ERIKSEN BA, 1974, PERCEPT PSYCHOPHYS, V16, P143, DOI 10.3758/BF03203267
Falkenstein M, 2000, BIOL PSYCHOL, V51, P87, DOI 10.1016/S0301-0511(99)00031-9
Fan J, 2002, J COGNITIVE NEUROSCI, V14, P340, DOI 10.1162/089892902317361886
Fan J, 2003, NEUROIMAGE, V18, P42, DOI 10.1006/nimg.2002.1319
Friedman NP, 2008, J EXP PSYCHOL GEN, V137, P201, DOI 10.1037/0096-3445.137.2.201
Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
Gerardi-Caulton G, 2000, DEVELOPMENTAL SCI, V3, P397, DOI 10.1111/1467-7687.00134
GRATTON G, 1983, ELECTROEN CLIN NEURO, V55, P468, DOI 10.1016/0013-4694(83)90135-9
Greenwood PM, 2005, J COGNITIVE NEUROSCI, V17, P1611, DOI 10.1162/089892905774597281
Gregoire J., 2005, CLIN EVALUATION INTE
Haznedar MM, 1997, AM J PSYCHIAT, V154, P1047
Henderson H, 2006, BRAIN COGNITION, V61, P96, DOI 10.1016/j.bandc.2005.12.009
Herrmann MJ, 2004, COGNITIVE BRAIN RES, V20, P294, DOI 10.1016/j.cogbrainres.2004.02.013
Herrmann MJ, 2003, PSYCHIAT RES, V120, P265, DOI 10.1016/S0165-1781(03)00188-4
Jackson SR, 1999, NEUROREPORT, V10, P861, DOI 10.1097/00001756-199903170-00035
Jensen A. R., 2006, CLOCKING MIND MENTAL
Johnstone SJ, 2009, INT J PSYCHOPHYSIOL, V72, P145, DOI 10.1016/j.ijpsycho.2008.11.007
Johnstone SJ, 2010, INT J PSYCHOPHYSIOL, V76, P174, DOI 10.1016/j.ijpsycho.2010.03.010
Johnstone SJ, 2013, INT J PSYCHOPHYSIOL, V87, P340, DOI 10.1016/j.ijpsycho.2012.07.170
Jonkman LM, 2007, BIOL PSYCHOL, V76, P217, DOI 10.1016/j.biopsycho.2007.08.004
Jonkman LM, 2007, CLIN NEUROPHYSIOL, V118, P1069, DOI 10.1016/j.clinph.2007.01.017
Keehn B, 2010, J CHILD PSYCHOL PSYC, V51, P1251, DOI 10.1111/j.1469-7610.2010.02257.x
Konrad K, 2006, BIOL PSYCHIAT, V59, P643, DOI 10.1016/j.biopsych.2005.08.013
Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4
Kopp B, 1996, PSYCHOPHYSIOLOGY, V33, P282, DOI 10.1111/j.1469-8986.1996.tb00425.x
Kort W., 2002, WISC 3 NL MANUAL DUT
Kratz O, 2011, INT J PSYCHOPHYSIOL, V81, P82, DOI 10.1016/j.ijpsycho.2011.05.008
Kuntsi J, 2001, J CHILD PSYCHOL PSYC, V42, P199, DOI 10.1017/S0021963001006709
Liotti M, 2005, CORTEX, V41, P377, DOI 10.1016/S0010-9452(08)70274-0
Liotti M, 2007, PSYCHOPHYSIOLOGY, V44, P936, DOI 10.1111/j.1469-8986.2007.00568.x
Lonigan C. J., 2001, DEV PSYCHOPATHOL, P60
Luck S. J., 2005, INTRO EVENT RELATED
Martel MM, 2006, J CHILD PSYCHOL PSYC, V47, P1175, DOI 10.1111/j.1469-7610.2006.01629.x
Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P277, DOI 10.1016/j.rasd.2011.05.009
Mullane JC, 2011, J ATTEN DISORD, V15, P310, DOI 10.1177/1087054710366384
Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165
Muris P, 2009, J PSYCHOPATHOL BEHAV, V31, P7, DOI 10.1007/s10862-008-9089-x
Neuhaus AH, 2007, J PSYCHIATR RES, V41, P635, DOI 10.1016/j.jpsychires.2006.06.012
Nieuwenhuis S, 2003, COGN AFFECT BEHAV NE, V3, P17, DOI 10.3758/CABN.3.1.17
Nigg JT, 2001, PSYCHOL BULL, V127, P571, DOI 10.1037//0033-2909.127.5.571
Oostenveld R, 2001, CLIN NEUROPHYSIOL, V112, P713, DOI 10.1016/S1388-2457(00)00527-7
Overbeek TJM, 2005, J PSYCHOPHYSIOL, V19, P319, DOI 10.1027/0269-8803.19.4.319
Overtoom CCE, 1998, J AM ACAD CHILD PSY, V37, P977, DOI 10.1097/00004583-199809000-00018
Pliszka SR, 2006, AM J PSYCHIAT, V163, P1052, DOI 10.1176/appi.ajp.163.6.1052
Posner M. I., 2004, TOPICS INTEGRATIVE N, p[J, 31]
POSNER MI, 1990, ANNU REV NEUROSCI, V13, P25, DOI 10.1146/annurev.neuro.13.1.25
Posner MI, 2000, DEV PSYCHOPATHOL, V12, P427, DOI 10.1017/S0954579400003096
Roeyers Thys H., 2011, SRS SCREEN INGLIS AU
Rothbart M. K., 1989, TEMPERAMENT CHILDHOO, P187
Rothbart M. K., 2006, HDB CHILD PSYCHOL, V3, P99, DOI DOI 10.1002/9780470147658.CHPSY0303
Rothbart MK, 2003, J PERS, V71, P1113, DOI 10.1111/1467-6494.7106009
Rueda MR, 2005, P NATL ACAD SCI USA, V102, P14931, DOI 10.1073/pnas.0506897102
Samyn V, 2011, RES DEV DISABIL, V32, P483, DOI 10.1016/j.ridd.2010.12.038
Samyn V., 2013, J ATTEN DISORD, VXX, P1
Santesso DL, 2011, PSYCHOPHYSIOLOGY, V48, P241, DOI 10.1111/j.1469-8986.2010.01056.x
Sengupta SM, 2012, J PSYCHIATR NEUROSCI, V37, P129, DOI 10.1503/jpn.110073
Sergeant J, 2000, NEUROSCI BIOBEHAV R, V24, P7, DOI 10.1016/S0149-7634(99)00060-3
Sergeant JA, 1999, HDB DISRUPTIVE BEHAV, P75
Shaffer D, 2000, J AM ACAD CHILD PSY, V39, P28, DOI 10.1097/00004583-200001000-00014
Simonds J, 2007, COGNITIVE DEV, V22, P474, DOI 10.1016/j.cogdev.2007.08.009
Sonuga-Barke EJS, 2010, NEUROPSYCHOL REV, V20, P86, DOI 10.1007/s11065-009-9115-0
South M, 2010, BIOL PSYCHOL, V85, P242, DOI 10.1016/j.biopsycho.2010.07.009
Swanson J., 2000, ATTENTIVE BRAIN, P445
Szuromi B, 2011, PSYCHOL MED, V41, P1529, DOI 10.1017/S0033291710001996
Tsai CL, 2011, RES AUTISM SPECT DIS, V5, P1092, DOI 10.1016/j.rasd.2010.12.004
Van De Voorde S, 2011, J CLIN EXP NEUROPSYC, V33, P753, DOI 10.1080/13803395.2011.554385
van Meel CS, 2007, PSYCHIAT RES, V151, P211, DOI 10.1016/j.psychres.2006.05.011
van Veen V, 2002, PHYSIOL BEHAV, V77, P477, DOI 10.1016/S0031-9384(02)00930-7
Verstraeten K, 2010, PERS INDIV DIFFER, V48, P59, DOI 10.1016/j.paid.2009.08.016
Wiersema J. R., 2006, J CHILD PSYCHOL PSYC, V47, P560
Wiersema JR, 2009, J ABNORM CHILD PSYCH, V37, P327, DOI 10.1007/s10802-008-9288-7
Wilcox RR, 2003, PSYCHOL METHODS, V8, P254, DOI 10.1037/1082-989X.8.3.254
Wild-Wall N, 2009, INT J PSYCHOPHYSIOL, V74, P19, DOI 10.1016/j.ijpsycho.2009.06.003
Yeung N, 2004, PSYCHOL REV, V111, P931, DOI 10.1037/0033-295x.111.4.931
NR 97
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAY
PY 2014
VL 99
BP 160
EP 171
DI 10.1016/j.biopsycho.2014.03.006
PG 12
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
Experimental
SC Psychology; Behavioral Sciences
GA AH2CQ
UT WOS:000335928700017
PM 24686073
ER
PT J
AU Oerlemans, AM
van der Meer, JMJ
van Steijn, DJ
de Ruiter, SW
de Bruijn, YGE
de Sonneville, LMJ
Buitelaar, JK
Rommelse, NNJ
AF Oerlemans, Anoek M.
van der Meer, Jolanda M. J.
van Steijn, Daphne J.
de Ruiter, Saskia W.
de Bruijn, Yvette G. E.
de Sonneville, Leo M. J.
Buitelaar, Jan K.
Rommelse, Nanda N. J.
TI Recognition of facial emotion and affective prosody in children with ASD
( plus ADHD) and their unaffected siblings
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders (ASD); Attention-deficit/hyperactivity
disorder (ADHD); Emotion recognition; Endophenotype; Sibling
ID AUTISM SPECTRUM DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
DEFICIT HYPERACTIVITY DISORDER; ENDOPHENOTYPE APPROACH; PROCESSING
STRATEGIES; SCHIZOPHRENIA; INFORMATION; SYMPTOMS; QUESTIONNAIRE;
HERITABILITY
AB Autism is a highly heritable and clinically heterogeneous neuropsychiatric disorder that frequently co-occurs with other psychopathologies, such as attention-deficit/hyperactivity disorder (ADHD). An approach to parse heterogeneity is by forming more homogeneous subgroups of autism spectrum disorder (ASD) patients based on their underlying, heritable cognitive vulnerabilities (endophenotypes). Emotion recognition is a likely endophenotypic candidate for ASD and possibly for ADHD. Therefore, this study aimed to examine whether emotion recognition is a viable endophenotypic candidate for ASD and to assess the impact of comorbid ADHD in this context. A total of 90 children with ASD (43 with and 47 without ADHD), 79 ASD unaffected siblings, and 139 controls aged 6-13 years, were included to test recognition of facial emotion and affective prosody. Our results revealed that the recognition of both facial emotion and affective prosody was impaired in children with ASD and aggravated by the presence of ADHD. The latter could only be partly explained by typical ADHD cognitive deficits, such as inhibitory and attentional problems. The performance of unaffected siblings could overall be considered at an intermediate level, performing somewhat worse than the controls and better than the ASD probands. Our findings suggest that emotion recognition might be a viable endophenotype in ASD and a fruitful target in future family studies of the genetic contribution to ASD and comorbid ADHD. Furthermore, our results suggest that children with comorbid ASD and ADHD are at highest risk for emotion recognition problems.
C1 [Oerlemans, Anoek M.; de Ruiter, Saskia W.; Rommelse, Nanda N. J.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
[Oerlemans, Anoek M.; van der Meer, Jolanda M. J.; van Steijn, Daphne J.; de Ruiter, Saskia W.; de Bruijn, Yvette G. E.; Buitelaar, Jan K.; Rommelse, Nanda N. J.] Univ Ctr, NL-6525 GC Nijmegen, Netherlands.
[van der Meer, Jolanda M. J.; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
[de Sonneville, Leo M. J.] Leiden Univ, Leiden Inst Brain & Cognit, Dept Clin Child & Adolescent Studies, Leiden, Netherlands.
RP Oerlemans, AM (reprint author), Univ Ctr, Reinier Postlaan 12, NL-6525 GC Nijmegen, Netherlands.
EM am.oerlemans@psy.umcn.nl
FU Netherlands Organisation for Scientific Research (NWO) [91610024]
FX This study was partly funded by a grant assigned to Dr. Rommelse by The
Netherlands Organisation for Scientific Research (NWO grant # 91610024).
The authors would like to thank all the parents, teachers, and children
who kindly participated.
CR Adolphs R, 2008, CURR BIOL, V18, P1090, DOI 10.1016/j.cub.2008.06.073
Allen AJ, 2009, SCHIZOPHR RES, V109, P24, DOI 10.1016/j.schres.2009.01.016
Almasy L, 2001, AM J MED GENET, V105, P42, DOI 10.1002/1096-8628(20010108)105:1<42::AID-AJMG1055>3.0.CO;2-9
Anokhin AP, 2010, BEHAV GENET, V40, P178, DOI 10.1007/s10519-010-9337-1
APA, 2000, DIAGN STAT MAN DIS
Aylward GP, 2002, DEV NEUROPSYCHOL, V21, P285, DOI 10.1207/S15326942DN2103_5
Baird Gillian, 2008, Practitioner, V252, P6
Baker KF, 2010, J AUTISM DEV DISORD, V40, P123, DOI 10.1007/s10803-009-0841-1
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Brookes K, 2006, MOL PSYCHIATR, V11, P934, DOI 10.1038/sj.mp.4001869
Buitelaar JK, 1999, DEV PSYCHOPATHOL, V11, P39, DOI 10.1017/S0954579499001947
Cadesky EB, 2000, J AM ACAD CHILD PSY, V39, P1160, DOI 10.1097/00004583-200009000-00016
Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
Charbonneau G, 2013, NEUROPSYCHOLOGIA, V51, P1002, DOI 10.1016/j.neuropsychologia.2013.02.009
Chen JY, 2012, NEUROIMAGE, V61, P866, DOI 10.1016/j.neuroimage.2012.03.022
Conners K, 1996, RATING SCALES ADHD
Corbett B, 2000, CHILD NEUROPSYCHOL, V6, P144, DOI 10.1076/chin.6.2.144.7056
Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
Da Fonseca D, 2009, CHILD PSYCHIAT HUM D, V40, P111, DOI 10.1007/s10578-008-0114-9
de Sonneville LMJ, 1999, COMP PSYCH, V6, P204
De Sonneville LMJ, 2005, TIJDSCHRIFT NEUROPSY, V1, P27
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
De Sonneville LMJ, 2002, J CLIN EXP NEUROPSYC, V24, P200, DOI 10.1076/jcen.24.2.200.989
Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0
Doyle AE, 2008, AM J MED GENET B, V147B, P1399, DOI 10.1002/ajmg.b.30868
Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
Grossman RB, 2010, J SPEECH LANG HEAR R, V53, P778, DOI 10.1044/1092-4388(2009/08-0127)
Groth-Marnat G., 1997, HDB PSYCHOL ASSESSME
Guttmann-Steinmetz S, 2009, J AUTISM DEV DISORD, V39, P976, DOI 10.1007/s10803-009-0706-7
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Heikkinen J, 2009, LOGOP PHONIATR VOCO, V1, P1
Hoff AL, 2005, AM J MED GENET B, V133B, P43, DOI 10.1002/ajmg.b.30120
Hopkins IM, 2011, J AUTISM DEV DISORD, V41, P1543, DOI 10.1007/s10803-011-1179-z
Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
Korpilahti P, 2007, J AUTISM DEV DISORD, V37, P1539, DOI 10.1007/s10803-006-0271-2
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
McCann J, 2003, INT J LANG COMM DIS, V38, P325, DOI 10.1080/1368282031000154204
Neves Maila de Castro Lourenço das, 2011, Rev. Bras. Psiquiatr., V33, P261, DOI 10.1590/S1516-44462011000300009
Nijmeijer JS, 2009, J ABNORM CHILD PSYCH, V37, P443, DOI 10.1007/s10802-008-9282-0
Norusis MJ, 1992, STAT PACKAGE SOCIAL
Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
Reichow B, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008511.pub2
Rommelse NNJ, 2007, J AM ACAD CHILD PSY, V46, P582, DOI 10.1097/chi.0b013e3180335af7
Rommelse NNJ, 2008, AM J HUM GENET, V83, P99, DOI 10.1016/j.ajhg.2008.06.006
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
SHAPIRO EG, 1993, DEV NEUROPSYCHOL, V9, P207
Sinzig J, 2008, EUR CHILD ADOLES PSY, V17, P63, DOI 10.1007/s00787-007-0637-9
Soorya LV, 2009, PRIMARY PSYCHIAT, V6, P48
Spencer MD, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.18
Tabachnick B., 2001, USING MULTIVARIATE S
Taylor E, 1991, EPIDEMIOLOGY CHILDHO
Tierney AL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039127
Uekermann J, 2010, NEUROSCI BIOBEHAV R, V34, P734, DOI 10.1016/j.neubiorev.2009.10.009
Uljarevic M, 2013, J AUTISM DEV DISORD, V43, P1517, DOI 10.1007/s10803-012-1695-5
van der Meer JMJ, 2012, J AM ACAD CHILD PSY, V51, P1160, DOI 10.1016/j.jaac.2012.08.024
van Steijn DJ, 2012, J CHILD PSYCHOL PSYC, V53, P954, DOI 10.1111/j.1469-7610.2012.02556.x
Viding E, 2007, BEHAV GENET, V37, P51, DOI 10.1007/s10519-006-9105-4
Vingerhoets G, 2003, NEUROPSYCHOLOGY, V17, P93, DOI 10.1037/0894-4105.17.1.93
Waldman ID, 2005, BIOL PSYCHIAT, V57, P1347, DOI 10.1016/j.biopsych.2005.03.002
Wang HM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040996
Wechsler D, 2002, WISC 3 HANDLEIDING
NR 71
TC 6
Z9 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
EI 1435-165X
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD MAY
PY 2014
VL 23
IS 5
BP 257
EP 271
DI 10.1007/s00787-013-0446-2
PG 15
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AH2MU
UT WOS:000335956400003
PM 23824472
ER
PT J
AU Wentz, E
Vujic, M
Karrstedt, EL
Erlandsson, A
Gillberg, C
AF Wentz, Elisabet
Vujic, Mihailo
Karrstedt, Ewa-Lotta
Erlandsson, Anna
Gillberg, Christopher
TI A case report of two male siblings with autism and duplication of
Xq13-q21, a region including three genes predisposing for autism
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Autism; Case report; Microarray analysis; Duplication of Xq13-q21
ID MENTAL-RETARDATION; INTERSTITIAL DUPLICATION; DODECAMER DUPLICATION;
SHORT STATURE; X-CHROMOSOME; MALE PROBAND; MUTATIONS; ANOMALIES; MOTHER
AB Autism spectrum disorder, severe behaviour problems and duplication of the Xq12 to Xq13 region have recently been described in three male relatives. To describe the psychiatric comorbidity and dysmorphic features, including craniosynostosis, of two male siblings with autism and duplication of the Xq13 to Xq21 region, and attempt to narrow down the number of duplicated genes proposed to be leading to global developmental delay and autism. We performed DNA sequencing of certain exons of the TWIST1 gene, the FGFR2 gene and the FGFR3 gene. We also performed microarray analysis of the DNA. In addition to autism, the two male siblings exhibited severe learning disability, self-injurious behaviour, temper tantrums and hyperactivity, and had no communicative language. Chromosomal analyses were normal. Neither of the two siblings showed mutations of the sequenced exons known to produce craniosynostosis. The microarray analysis detected an extra copy of a region on the long arm of chromosome X, chromosome band Xq13.1-q21.1. Comparison of our two cases with previously described patients allowed us to identify three genes predisposing for autism in the duplicated chromosomal region. Sagittal craniosynostosis is also a new finding linked to the duplication.
C1 [Wentz, Elisabet; Gillberg, Christopher] Univ Gothenburg, Gillberg Neuropsychiat Ctr, SE-41119 Gothenburg, Sweden.
[Vujic, Mihailo; Karrstedt, Ewa-Lotta; Erlandsson, Anna] Sahlgrens Univ Hosp, Dept Clin Genet, Gothenburg, Sweden.
[Gillberg, Christopher] Univ Glasgow, Yorkhill Hosp, Dept Child & Adolescent Psychiat, Glasgow, Lanark, Scotland.
[Gillberg, Christopher] UCL, Inst Child Hlth, London, England.
RP Wentz, E (reprint author), Univ Gothenburg, Gillberg Neuropsychiat Ctr, Kungsgatan 12, SE-41119 Gothenburg, Sweden.
EM elisabet.wentz@vgregion.se
CR American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
APA, 1987, DIAGN STAT MAN MENT
Apacik C, 1996, CLIN GENET, V50, P63
Beyer KS, 2002, AM J MED GENET, V114, P110, DOI 10.1002/ajmg.1613
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Cheng SF, 2005, AM J MED GENET A, V135A, P308, DOI 10.1002/ajmg.a.30613
CREMERS FPM, 1987, HUM GENET, V77, P23
Hou Jia-Woei, 2004, Chang Gung Med J, V27, P685
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kaya N, 2012, ANN NEUROL, V71, P498, DOI 10.1002/ana.22673
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Lugtenberg D, 2009, AM J MED GENET A, V149A, P760, DOI 10.1002/ajmg.a.32742
Megarbane A, 2002, AM J MED GENET, V109, P323, DOI 10.1002/ajmg.10370
Michaelis RC, 2000, J AUTISM DEV DISORD, V30, P355, DOI 10.1023/A:1005583517994
Morey-Canellas J, 2003, EUR CHILD ADOLES PSY, V12, P100, DOI 10.1007/s00787-003-0289-3
MUSCATELLI F, 1992, HUM GENET, V88, P691, DOI 10.1007/BF02265299
Nordin V, 1996, DEV MED CHILD NEUROL, V38, P297
Raymond FL, 2006, J MED GENET, V43, P193, DOI 10.1136/jmg.2005.033043
Saemundsen E, 2010, J INTELL DISABIL RES, V54, P727, DOI 10.1111/j.1365-2788.2010.01300.x
Shapira M, 1997, AM J MED GENET, V72, P409, DOI 10.1002/(SICI)1096-8628(19971112)72:4<409::AID-AJMG7>3.0.CO;2-L
STEINBACH P, 1980, HUM GENET, V54, P309, DOI 10.1007/BF00291574
THODE A, 1988, AM J MED GENET, V30, P239, DOI 10.1002/ajmg.1320300125
VEJERSLEV LO, 1985, CLIN GENET, V27, P276
Visser WE, 2010, HUM MOL GENET, V19, P4189, DOI 10.1093/hmg/ddq337
YOKOYAMA Y, 1992, AM J MED GENET, V42, P660, DOI 10.1002/ajmg.1320420506
NR 25
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
EI 1435-165X
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD MAY
PY 2014
VL 23
IS 5
BP 329
EP 336
DI 10.1007/s00787-013-0455-1
PG 8
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AH2MU
UT WOS:000335956400009
PM 23974867
ER
PT J
AU Palmqvist, M
Edman, G
Bolte, S
AF Palmqvist, Margita
Edman, Gunnar
Bolte, Sven
TI Screening for substance use disorders in neurodevelopmental disorders: a
clinical routine?
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Psychiatry; Assessment; Toxicology; Questionnaire; Best practice;
Guidelines; Autism; ADHD; Asperger syndrome; Drugs
ID AUTISM SPECTRUM DISORDERS; PREVALENCE; CHILDREN; COHORT; ADHD
AB Evidence suggests that substance use disorders (SUD) tend to be underdiagnosed in psychiatry. The objective of this study was to investigate whether drug and alcohol screening is a clinical routine in the assessment of two prominent neurodevelopmental disorders, namely ADHD and autism spectrum disorder (ASD). We surveyed drug and alcohol screening routines in 34 general child and adolescent (only practice for adolescents, not children, was assessed) and 29 adult psychiatric outpatient departments in Stockholm County, Sweden. Structured telephone interviews mapping SUD screening procedures were conducted with department representatives in charge. Only a minority of child and adolescent departments regularly used SUD screening questionnaires (6 %) in ADHD and ASD assessment, while this was more common in adult psychiatry (55 %). Urine/blood-based toxicology tests were always used in 28 % and sometimes or in case of clinical suspicion in 38 % of the adult units. Such tests were used sometimes or in case of clinical suspicion in 15 % of the child psychiatric departments, but never routinely. Findings reveal that screening for SUD in ADHD and ASD is not an integral part of routine clinical assessments in psychiatry, although increasingly an integral part of many clinical guidelines. Thus, SUD might be underdiagnosed in neurodevelopmental disorders, which could be particularly true for child and adolescent psychiatry settings.
C1 [Palmqvist, Margita; Edman, Gunnar] Tiohundra AB, Dept Psychiat, Neuropsychiat Unit, Norrtalje, Sweden.
[Bolte, Sven] Karolinska Inst, CAP Res Ctr, Ctr Neurodev Disorders, Dept Womens & Childrens Hlth,Neuropsychiat Unit, S-11330 Stockholm, Sweden.
[Bolte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden.
RP Bolte, S (reprint author), Karolinska Inst, CAP Res Ctr, Ctr Neurodev Disorders, Dept Womens & Childrens Hlth,Neuropsychiat Unit, Gavlegatan 22, S-11330 Stockholm, Sweden.
EM sven.bolte@ki.se
FU Swedish Research Council [523-2009-7054]
FX We sincerely thank all clinical units in Stockholm County which
participated in this study. Sven Bolte was supported by the Swedish
Research Council (Grant nr. 523-2009-7054).
CR Abdallah MW, 2011, EUR CHILD ADOLES PSY, V20, P599, DOI 10.1007/s00787-011-0220-2
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
DRAKE RE, 1993, COMMUNITY MENT HLT J, V29, P175, DOI 10.1007/BF00756343
Hansen SS, 2000, ACTA PSYCHIAT SCAND, V102, P432, DOI 10.1034/j.1600-0447.2000.102006432.x
Levin Frances R, 2007, J Clin Psychiatry, V68, pe18
Mallin Robert, 2002, Subst Abus, V23, P115, DOI 10.1023/A:1015391323164
National Institute on Drug Abuse, 2008, NAT I DRUG AB RES RE
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
Regier DA, 2009, AM J PSYCHIAT, V166, P645, DOI 10.1176/appi.ajp.2009.09020279
Riggs P, 2008, SUBST ABUS, V29, P51, DOI 10.1080/08897070802218794
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
SLL, 2010, REG VARDPR ADHD LIND
Squeglia LM, 2009, CLIN EEG NEUROSCI, V40, P31
SZUSTER RR, 1990, AM J DRUG ALCOHOL AB, V16, P319, DOI 10.3109/00952999009001593
van Holst Ruth Janke, 2011, Curr Drug Abuse Rev, V4, P42
Wilens TE, 2011, J AM ACAD CHILD PSY, V50, P543, DOI 10.1016/j.jaac.2011.01.021
Wilson CR, 2004, PEDIATRICS, V114, pE536, DOI 10.1542/peds.2004-0098
World Health Organization, 2004, GLOB HLTH OBS
NR 18
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
EI 1435-165X
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD MAY
PY 2014
VL 23
IS 5
BP 365
EP 368
DI 10.1007/s00787-013-0459-x
PG 4
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AH2MU
UT WOS:000335956400013
PM 23949101
ER
PT J
AU Wang, XS
Peng, CZ
Cai, WJ
Xia, J
Jin, DZ
Dai, YQ
Luo, XG
Klyachko, VA
Deng, PY
AF Wang, Xiao-Sheng
Peng, Chun-Zi
Cai, Wei-Jun
Xia, Jian
Jin, Daozhong
Dai, Yuqiao
Luo, Xue-Gang
Klyachko, Vitaly A.
Deng, Pan-Yue
TI Activity-dependent regulation of release probability at excitatory
hippocampal synapses: a crucial role of fragile X mental retardation
protein in neurotransmission
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE excitatory postsynaptic current; release probability; short-term
plasticity; mouse; hippocampus; fragile X syndrome
ID SHORT-TERM PLASTICITY; SYNAPTIC INFORMATION-TRANSMISSION; RAT ENTORHINAL
CORTEX; FMR1 KNOCKOUT MICE; MOUSE MODEL; GLUTAMATE RELEASE;
SOMATOSENSORY CORTEX; PRESYNAPTIC FMR1; NMDA RECEPTORS; IN-VITRO
AB Transcriptional silencing of the Fmr1 gene encoding fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), the most common form of inherited intellectual disability and the leading genetic cause of autism. FMRP has been suggested to play important roles in regulating neurotransmission and short-term synaptic plasticity at excitatory hippocampal and cortical synapses. However, the origins and mechanisms of these FMRP actions remain incompletely understood, and the role of FMRP in regulating synaptic release probability and presynaptic function remains debated. Here we used variance-mean analysis and peak-scaled nonstationary variance analysis to examine changes in both presynaptic and postsynaptic parameters during repetitive activity at excitatory CA3-CA1 hippocampal synapses in a mouse model of FXS. Our analyses revealed that loss of FMRP did not affect the basal release probability or basal synaptic transmission, but caused an abnormally elevated release probability specifically during repetitive activity. These abnormalities were not accompanied by changes in excitatory postsynaptic current kinetics, quantal size or postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor conductance. Our results thus indicate that FMRP regulates neurotransmission at excitatory hippocampal synapses specifically during repetitive activity via modulation of release probability in a presynaptic manner. Our study suggests that FMRP function in regulating neurotransmitter release is an activity-dependent phenomenon that may contribute to the pathophysiology of FXS.
C1 [Wang, Xiao-Sheng; Cai, Wei-Jun; Luo, Xue-Gang; Deng, Pan-Yue] Cent S Univ, Dept Histol & Embryol, Dept Anat & Neurobiol, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.
[Peng, Chun-Zi] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Xia, Jian] Cent S Univ, Inst Neurol, Xiangya Hosp, Changsha 410013, Hunan, Peoples R China.
[Jin, Daozhong] Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA.
[Dai, Yuqiao] Univ Missouri, Sch Pharm, Div Pharmacol & Toxicol, Kansas City, MO 64110 USA.
[Klyachko, Vitaly A.; Deng, Pan-Yue] Washington Univ, Sch Med, Dept Cell Biol & Physiol, Dept Biomed Engn, St Louis, MO 63110 USA.
RP Deng, PY (reprint author), Cent S Univ, Dept Histol & Embryol, Dept Anat & Neurobiol, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.
EM klyachko@wustl.edu; pydeng@yahoo.com
FU Shenghua Scholar Program of Central South University; National Natural
Science Foundation of China [81370248, 81271299]; NINDS [R01 NS081972];
FRAXA Foundation; McDonnell Center for Systems Neuroscience, USA
FX This work was partly supported by the Shenghua Scholar Program of
Central South University and grants from the National Natural Science
Foundation of China (81370248 and 81271299), NINDS R01 NS081972, FRAXA
Foundation, and McDonnell Center for Systems Neuroscience, USA.
CR Antar LN, 2006, MOL CELL NEUROSCI, V32, P37, DOI 10.1016/j.mcn.2006.02.001
Bagnall MW, 2011, NEURON, V71, P180, DOI 10.1016/j.neuron.2011.05.032
Balaji J, 2008, J NEUROSCI, V28, P6742, DOI 10.1523/JNEUROSCI.1082-08.2008
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Benke TA, 1998, NATURE, V393, P793
Cheung G, 2010, J NEUROSCI, V30, P8151, DOI 10.1523/JNEUROSCI.0293-10.2010
Clements JD, 2000, TRENDS NEUROSCI, V23, P105, DOI 10.1016/S0166-2236(99)01520-9
Clements JD, 2003, J NEUROSCI METH, V130, P115, DOI 10.1016/j.jneumeth.2003.09.019
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
Deng PY, 2010, J NEUROSCI, V30, P5136, DOI 10.1523/JNEUROSCI.5711-09.2010
Deng PY, 2011, J NEUROSCI, V31, P10971, DOI 10.1523/JNEUROSCI.2021-11.2011
Deng PY, 2013, NEURON, V77, P696, DOI 10.1016/j.neuron.2012.12.018
Deng PY, 2007, J NEUROPHYSIOL, V97, P727, DOI 10.1152/jn.01089.2006
Fitzjohn SM, 2001, J PHYSIOL-LONDON, V537, P421, DOI 10.1111/j.1469-7793.2001.00421.x
Gatto CL, 2008, DEVELOPMENT, V135, P2637, DOI 10.1242/dev.022244
Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008
Hanson JE, 2007, J NEUROSCI, V27, P4014, DOI 10.1523/JNEUROSCI.4717-06.2007
Huang CH, 2010, J NEUROSCI, V30, P11994, DOI 10.1523/JNEUROSCI.2381-10.2010
Klemmer P, 2011, J BIOL CHEM, V286, P25495, DOI 10.1074/jbc.M110.210260
Klyachko VA, 2006, J NEUROSCI, V26, P6945, DOI 10.1523/JNEUROSCI.1382-06.2006
Larkman AU, 1997, J PHYSIOL-LONDON, V505, P457, DOI 10.1111/j.1469-7793.1997.457bb.x
Lei SB, 2002, NEURON, V33, P921, DOI 10.1016/S0896-6273(02)00608-6
Lei SB, 2003, J NEUROSCI, V23, P9786
Liao LJ, 2008, P NATL ACAD SCI USA, V105, P15281, DOI 10.1073/pnas.0804678105
Liu GS, 1999, NEURON, V22, P395, DOI 10.1016/S0896-6273(00)81099-5
McAllister AK, 2000, P NATL ACAD SCI USA, V97, P6173, DOI 10.1073/pnas.100126497
Ng MC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051456
Patel AB, 2013, J NEUROSCI, V33, P2593, DOI 10.1523/JNEUROSCI.2447-12.2013
Pfeiffer BE, 2009, NEUROSCIENTIST, V15, P549, DOI 10.1177/1073858409333075
Pfeiffer BE, 2007, J NEUROSCI, V27, P3120, DOI 10.1523/JNEUROSCI.0054-07.2007
Pilpel Y, 2009, J PHYSIOL-LONDON, V587, P787, DOI 10.1113/jphysiol.2008.160929
Rotman Z, 2011, J NEUROSCI, V31, P14800, DOI 10.1523/JNEUROSCI.3231-11.2011
Saheki Y, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005645
Scott R, 2007, J ANAT, V210, P642, DOI 10.1111/j.1469-7580.2007.00728.x
Silver RA, 2003, J NEUROSCI METH, V130, P127, DOI 10.1016/j.jneumeth.2003.09.030
SUDHOF TC, 1995, NATURE, V375, P645, DOI 10.1038/375645a0
Suvrathan A, 2010, P NATL ACAD SCI USA, V107, P11591, DOI 10.1073/pnas.1002262107
Till SM, 2012, HUM MOL GENET, V21, P2143, DOI 10.1093/hmg/dds030
Till S.M., 2010, LEARN MEMORY, V18, P39, DOI 10.1101/lm.1958811
Traynelis SF, 1998, TRENDS NEUROSCI, V21, P137, DOI 10.1016/S0166-2236(98)01238-7
TRAYNELIS SF, 1993, NEURON, V11, P279, DOI 10.1016/0896-6273(93)90184-S
Wang SP, 2012, CEREB CORTEX, V22, P584, DOI 10.1093/cercor/bhr131
Wesseling JF, 2002, J NEUROSCI, V22, P9708
Wijetunge LS, 2013, NEUROPHARMACOLOGY, V68, P83, DOI 10.1016/j.neuropharm.2012.11.028
Zhang J, 2009, J NEUROPHYSIOL, V101, P2572, DOI 10.1152/jn.90558.2008
Zhang YQ, 2001, CELL, V107, P591, DOI 10.1016/S0092-8674(01)00589-X
Zhou Q, 2000, J PHYSIOL-LONDON, V525, P195, DOI 10.1111/j.1469-7793.2000.t01-1-00195.x
Zucker RS, 2002, ANNU REV PHYSIOL, V64, P355, DOI 10.1146/annurev.physiol.64.092501.114547
NR 49
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD MAY
PY 2014
VL 39
IS 10
BP 1602
EP 1612
DI 10.1111/ejn.12546
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AH2JO
UT WOS:000335947500005
PM 24646437
ER
PT J
AU Sparks, SE
Wassif, CA
Goodwin, H
Conley, SK
Lanham, DC
Kratz, LE
Hyland, K
Gropman, A
Tierney, E
Porter, FD
AF Sparks, S. E.
Wassif, C. A.
Goodwin, H.
Conley, S. K.
Lanham, D. C.
Kratz, L. E.
Hyland, K.
Gropman, A.
Tierney, E.
Porter, F. D.
TI Decreased cerebral spinal fluid neurotransmitter levels in
Smith-Lemli-Opitz syndrome
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
ID HUMAN SEROTONIN(1A) RECEPTOR; CEREBROSPINAL-FLUID;
CHOLESTEROL-BIOSYNTHESIS; LIGAND-BINDING; OPTIZ-SYNDROME; MOUSE MODEL;
7-DEHYDROCHOLESTEROL; BEHAVIOR; AUTISM; METABOLITES
AB Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive, multiple congenital anomaly syndrome with cognitive impairment and a distinct behavioral phenotype that includes autistic features. SLOS is caused by a defect in 3 beta-hydroxysterol Delta(7)-reductase which leads to decreased cholesterol levels and elevated cholesterol precursors, specifically 7- and 8-dehydrocholesterol. However, the pathological processes contributing to the neurological abnormalities in SLOS have not been defined. In view of prior data suggesting defects in SLOS in vesicular release and given the association of altered serotonin metabolism with autism, we were interested in measuring neurotransmitter metabolite levels in SLOS to assess their potential to be used as biomarkers in therapeutic trials. We measured cerebral spinal fluid levels of serotonin and dopamine metabolites, 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) respectively, in 21 SLOS subjects. Results were correlated with the SLOS anatomical severity score, Aberrant Behavior Checklist scores and concurrent sterol biochemistry. Cerebral spinal fluid (CSF) levels of both 5HIAA and HVA were significantly reduced in SLOS subjects. In individual patients, the levels of both 5HIAA and HVA were reduced to a similar degree. CSF neurotransmitter metabolite levels did not correlate with either CSF sterols or behavioral measures. This is the first study demonstrating decreased levels of CSF neurotransmitter metabolites in SLOS. We propose that decreased levels of neurotransmitters in SLOS are caused by a sterol-related defect in synaptic vesicle formation and that CSF 5HIAA and HVA will be useful biomarkers in development of future therapeutic trials.
C1 [Sparks, S. E.] Carolinas Med Ctr, Dept Pediat, Charlotte, NC 28203 USA.
[Wassif, C. A.; Goodwin, H.; Conley, S. K.; Porter, F. D.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, NIH, Bethesda, MD USA.
[Lanham, D. C.; Tierney, E.] Kennedy Krieger Inst, Dept Psychiat, Baltimore, MD USA.
[Kratz, L. E.] Kennedy Krieger Inst, Biochem Genet Lab, Baltimore, MD USA.
[Hyland, K.] Med Neurogenet, Atlanta, GA USA.
[Gropman, A.] Childrens Natl Med Ctr, Ctr Neurosci Res, Washington, DC 20010 USA.
RP Porter, FD (reprint author), 10 CRC,Rm 5-2571,10 Ctr Dr, Bethesda, MD 20892 USA.
EM fdporter@mail.nih.gov
FU National Institute of Child Health and Human Development; Office of Rare
Diseases; NIH Clinical Center; National Center for Advancing
Translational Sciences (NCATS) a component of the National Institutes of
Health (NIH) [UL1 TR 000424-06]; NIH Roadmap for Medical Research
FX This work was supported by the intramural program of the National
Institute of Child Health and Human Development and a Bench-to-Bedside
award from the Office of Rare Diseases and the NIH Clinical Center.
Autism Speaks, the Johns Hopkins Institute for Clinical and
Translational Research (ICTR) which is funded in part by Grant Number
UL1 TR 000424-06 from the National Center for Advancing Translational
Sciences (NCATS) a component of the National Institutes of Health (NIH),
and NIH Roadmap for Medical Research. Its contents are solely the
responsibility of the authors and do not necessarily represent the
official view of the Johns Hopkins ICTR, NCATS or NIH. We would like to
thank Richard Kelly for critical review of this manuscript. We would
like to express our appreciation to the patients and families that
participated in this study.
CR AMAN MG, 1985, AM J MENT DEF, V89, P492
Bartholomeusz HH, 2002, NEUROPEDIATRICS, V33, P239, DOI 10.1055/s-2002-36735
Caruso PA, 2004, NEURORADIOLOGY, V46, P3, DOI 10.1007/s00234-003-1110-1
Fantini J, 2009, BBA-BIOMEMBRANES, V1788, P2345, DOI 10.1016/j.bbamem.2009.08.016
Fitzky BU, 1998, P NATL ACAD SCI USA, V95, P8181, DOI 10.1073/pnas.95.14.8181
Fliesler SJ, 1999, INVEST OPHTH VIS SCI, V40, P1792
Gondre-Lewis MC, 2006, J CELL SCI, V119, P1876, DOI 10.1242/jcs.02906
HYLAND K, 1993, PEDIATR RES, V34, P10, DOI 10.1203/00006450-199307000-00003
Hyland K, 2008, CLIN CHEM, V54, P633, DOI 10.1373/clinchem.2007.099986
IRONS M, 1993, LANCET, V341, P1414, DOI 10.1016/0140-6736(93)90983-N
KELLEY RI, 1995, CLIN CHIM ACTA, V236, P45, DOI 10.1016/0009-8981(95)06038-4
Kelley RI, 2000, J MED GENET, V37, P321, DOI 10.1136/jmg.37.5.321
Krakowiak PA, 2000, AM J MED GENET, V94, P214, DOI 10.1002/1096-8628(20000918)94:3<214::AID-AJMG7>3.0.CO;2-R
Lee RWY, 2013, AM J MED GENET A, V161, P2407, DOI 10.1002/ajmg.a.36096
Lee RWY, 2013, PEDIATR NEUROL, V49, P107, DOI 10.1016/j.pediatrneurol.2013.03.015
Mueller C, 2003, AM J MED GENET A, V123A, P100, DOI 10.1002/ajmg.a.20491
NARAYAN M, 1993, BIOL PSYCHIAT, V33, P630, DOI 10.1016/0006-3223(93)90102-J
Paila YD, 2011, MOL BIOSYST, V7, P224, DOI 10.1039/c0mb00148a
Paila YD, 2008, BBA-BIOMEMBRANES, V1778, P1508, DOI 10.1016/j.bbamem.2008.03.002
Porter FD, 2000, MOL GENET METAB, V71, P163, DOI 10.1006/mgme.2000.3069
Porter FD, 2008, EUR J HUM GENET, V16, P535, DOI 10.1038/ejhg.2008.10
Rosa Patrizia, 2010, Commun Integr Biol, V3, P352
Ryan AK, 1998, J MED GENET, V35, P558, DOI 10.1136/jmg.35.7.558
Scott MM, 2005, INT J DEV NEUROSCI, V23, P277, DOI 10.1016/j.ijdevneu.2004.05.012
Shrivastava S, 2010, BIOCHEMISTRY-US, V49, P5426, DOI 10.1021/bi100276b
Singh P, 2007, BIOCHEM BIOPH RES CO, V358, P495, DOI 10.1016/j.bbrc.2007.04.135
Sjogren B, 2008, N-S ARCH PHARMACOL, V378, P441, DOI 10.1007/s00210-008-0323-6
SMITH DW, 1964, J PEDIATR-US, V64, P210, DOI 10.1016/S0022-3476(64)80264-X
SURTEES R, 1994, CLIN SCI, V86, P697
Tierney E, 2010, AM J MED GENET A, V152A, P91, DOI 10.1002/ajmg.a.33148
Tierney E, 2001, AM J MED GENET, V98, P191, DOI 10.1002/1096-8628(20010115)98:2<191::AID-AJMG1030>3.0.CO;2-M
Waage-Baudet H, 2003, INT J DEV NEUROSCI, V21, P451, DOI 10.1016/j.ijdevneu.2003.09.002
Wassif CA, 2001, HUM MOL GENET, V10, P555, DOI 10.1093/hmg/10.6.555
Wassif CA, 1998, AM J HUM GENET, V63, P55, DOI 10.1086/301936
Waterham HR, 2000, BBA-MOL CELL BIOL L, V1529, P340, DOI 10.1016/S1388-1981(00)00159-1
NR 35
TC 2
Z9 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
EI 1573-2665
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD MAY
PY 2014
VL 37
IS 3
BP 415
EP 420
DI 10.1007/s10545-013-9672-5
PG 6
WC Endocrinology & Metabolism; Genetics & Heredity
SC Endocrinology & Metabolism; Genetics & Heredity
GA AG9NH
UT WOS:000335745700011
PM 24500076
ER
PT J
AU Ben-Sasson, A
Habib, S
Tirosh, E
AF Ben-Sasson, Ayelet
Habib, Sonia
Tirosh, Emanuel
TI Feasibility and Validity of Early Screening for Identifying Infants With
Poor Social-Communication Development in a Well-Baby Clinic System
SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
LA English
DT Article
DE Autism; ASD; Social development; Community screening; Infants;
Feasibility; Validity
ID AUTISM SPECTRUM DISORDERS; EARLY IDENTIFICATION; PRETERM INFANTS;
PRIMARY-CARE; CHILDREN; AGE; PREVALENCE; INSTRUMENT; TODDLERS; RISK
AB Objective: This study examined the feasibility and validity of implementing an autism spectrum disorders (ASD) screening for 12-month-old infants. Method: Parents of 583 infants, 12 months of age attending well baby clinics (WBCs), completed the First Year Inventory-Lite (FYI-L). Ten infants who failed the FYI-L and a subset of 12 infants who passed the identified FYI-L were evaluated using the Autism Observation Scale for Infants (AOSI) and the Mullen Scales of Early Learning. Information regarding social-communication development >= 24 months of age was extracted from medical records of 153 of the 583 infants. Results: Mean response rate across clinics was 26.63%. Infants at risk compared to controls showed significantly higher scores on the AOSI, lower composite scores on the MSEL, and a higher rate of referral for a developmental evaluation. At 24 months, 95% of infants who were negatively screened had no social-communication problems on their medical records; 60% of those who were screened positive had documented problems on medical records. Conclusion: ASD screening using the FYI-L at 12 months in a healthcare setting identifies infants with poor social-communication development, yet parents had low compliance with screening. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ben-Sasson, Ayelet] Univ Haifa, Fac Social Welf & Hlth Sci, Dept Occupat Therapy, IL-31999 Haifa, Israel.
[Habib, Sonia] Minist Hlth, Haifa, Israel.
[Tirosh, Emanuel] Technion Israel Inst Technol, Bnai Zion Med Ctr, Hannah Khousy Child Dev Ctr, Haifa, Israel.
[Tirosh, Emanuel] Technion Israel Inst Technol, Rappoport Fac Med, Haifa, Israel.
RP Ben-Sasson, A (reprint author), Univ Haifa, Fac Social Welf & Hlth Sci, Dept Occupat Therapy, IL-31999 Haifa, Israel.
EM asasson@univ.haifa.ac.il
FU Israeli Ministry of Health; European International Reintegration Grant
(IRG) [203715]
FX This work was supported by a feasibility grant from the Israeli Ministry
of Health and a European International Reintegration Grant (IRG: No.
203715). We are grateful to Profs. Grace Baranek, Alice Carter, David
Oppenheim, Nurit Yirmiya, and Lonnie Zwaigenbaum for their insightful
feedback regarding the design of this study.
CR Al- Qabandi M., 2011, PEDIATRICS, V128, P1098
Arain M, 2010, BMC MED RES METHODOL, V10, P1
Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
Baranek G. T., 2009, 1 YEAR INVENTO UNPUB
Baranek GT, 2003, 1 YEAR INVENTORY FYI
Barbaro J, 2011, J PEDIATR NURS, V26, P334, DOI 10.1016/j.pedn.2010.04.007
Ben-Sasson A, 2013, RES AUTISM SPECT DIS, V7, P879, DOI 10.1016/j.rasd.2013.03.006
Ben-Sasson A, 2012, J AUTISM DEV DISORD, V42, P1906, DOI 10.1007/s10803-011-1436-1
Bryson S. E., COMPREHENSI IN PRESS
Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
Carlsson LH, 2010, ACTA PAEDIATR, V99, P1897, DOI 10.1111/j.1651-2227.2010.01958.x
Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Darrah J, 2003, EARLY HUM DEV, V72, P97, DOI 10.1016/S0378-3782(03)00027-6
Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
Gura GF, 2011, J DEV BEHAV PEDIATR, V32, P48, DOI 10.1097/DBP.0b013e3182040aea
Inada N, 2010, RES AUTISM SPECT DIS, V4, P605, DOI 10.1016/j.rasd.2009.12.003
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
Miller JS, 2011, PEDIATRICS, V127, P866, DOI 10.1542/peds.2010-0136
Mullen E, 1995, MULLEN SCALES EARLY
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Reznick JS, 2007, J AUTISM DEV DISORD, V37, P1691, DOI 10.1007/s10803-006-0303-y
Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
Sheridan M., 1987, CHILDRENS DEV PROGRE
Stephens BE, 2012, J DEV BEHAV PEDIATR, V33, P535, DOI 10.1097/DBP.0b013e31825fd0af
TIROSH E, 1993, DEV MED CHILD NEUROL, V35, P238
Turner-Brown L. M., 2012, AUTISM, V17, P527
Veness C, 2012, AUTISM, V16, P163, DOI 10.1177/1362361311399936
Webb P. L., 2011, JNP-J NURSE PRACT, V7, P229, DOI 10.1016/j.nurpra.2010.07.008
Wetherby AM, 2008, AUTISM, V12, P487, DOI 10.1177/1362361308094501
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 34
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0882-5963
J9 J PEDIATR NURS
JI J. Pediatr. Nurs.
PD MAY-JUN
PY 2014
VL 29
IS 3
BP 238
EP 247
DI 10.1016/j.pedn.2013.11.001
PG 10
WC Nursing; Pediatrics
SC Nursing; Pediatrics
GA AG9JF
UT WOS:000335734700009
PM 24333238
ER
PT J
AU Vulto-van Silfhout, AT
Rajamanickam, S
Jensik, PJ
Vergult, S
de Rocker, N
Newhall, KJ
Raghavan, R
Reardon, SN
Jarrett, K
McIntyre, T
Bulinski, J
Ownby, SL
Huggenvik, JI
McKnight, GS
Rose, GM
Cai, X
Willaert, A
Zweier, C
Endele, S
De Ligt, J
Van Bon, BWM
Lugtenberg, D
de Vries, PF
Veltman, JA
van Bokhoven, H
Brunner, HG
Rauch, A
De Brouwer, APM
Carvill, GL
Hoischen, A
Mefford, HC
Eichler, EE
Vissers, LELM
Menten, B
Collard, MW
de Vries, BBA
AF Vulto-van Silfhout, Anneke T.
Rajamanickam, Shivakumar
Jensik, Philip J.
Vergult, Sarah
de Rocker, Nina
Newhall, Kathryn J.
Raghavan, Ramya
Reardon, Sara N.
Jarrett, Kelsey
McIntyre, Tara
Bulinski, Joseph
Ownby, Stacy L.
Huggenvik, Jodi I.
McKnight, G. Stanley
Rose, Gregory M.
Cai, Xiang
Willaert, Andy
Zweier, Christiane
Endele, Sabine
de Ligt, Joep
van Bon, Bregje W. M.
Lugtenberg, Dorien
de Vries, Petra F.
Veltman, Joris A.
van Bokhoven, Hans
Brunner, Han G.
Rauch, Anita
de Brouwer, Arjan P. M.
Carvill, Gemma L.
Hoischen, Alexander
Mefford, Heather C.
Eichler, Evan E.
Vissers, Lisenka E. L. M.
Menten, Bjorn
Collard, Michael W.
de Vries, Bert B. A.
TI Mutations Affecting the SAND Domain of DEAF1 Cause Intellectual
Disability with Severe Speech Impairment and Behavioral Problems
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; CELL-CYCLE ENTRY; FACTOR-I DEAF-1; RECEPTOR GENE;
PROTEIN; EXPRESSION; DISEASE; AUTISM; NUDR; TRANSCRIPTION
AB Recently, we identified in two individuals with intellectual disability (ID) different de novo mutations in DEAF1, which encodes a transcription factor with an important role in embryonic development. To ascertain whether these mutations in DEAF1 are causative for the ID phenotype, we performed targeted resequencing of DEAF1 in an additional cohort of over 2,300 individuals with unexplained ID and identified two additional individuals with de novo mutations in this gene. All four individuals had severe ID with severely affected speech development, and three showed severe behavioral problems. DEAF1 is highly expressed in the CNS, especially during early embryonic development. All four mutations were missense mutations affecting the SAND domain of DEAF1. Altered DEAF1 harboring any of the four amino acid changes showed impaired transcriptional regulation of the DEAF1 promoter. Moreover, behavioral studies in mice with a conditional knockout of Deaf1 in the brain showed memory deficits and increased anxiety-like behavior. Our results demonstrate that mutations in DEAF1 cause ID and behavioral problems, most likely as a result of impaired transcriptional regulation by DEAF1.
C1 [Vulto-van Silfhout, Anneke T.; de Ligt, Joep; van Bon, Bregje W. M.; Lugtenberg, Dorien; de Vries, Petra F.; Veltman, Joris A.; van Bokhoven, Hans; Brunner, Han G.; de Brouwer, Arjan P. M.; Hoischen, Alexander; Vissers, Lisenka E. L. M.; de Vries, Bert B. A.] Radford Univ, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands.
[Rajamanickam, Shivakumar; Jensik, Philip J.; Raghavan, Ramya; Reardon, Sara N.; Jarrett, Kelsey; McIntyre, Tara; Bulinski, Joseph; Ownby, Stacy L.; Huggenvik, Jodi I.; Rose, Gregory M.; Cai, Xiang; Collard, Michael W.] So Illinois Univ, Sch Med, Dept Physiol, Carbondale, IL 62901 USA.
[Rajamanickam, Shivakumar; Jensik, Philip J.; Raghavan, Ramya; Reardon, Sara N.; Jarrett, Kelsey; McIntyre, Tara; Bulinski, Joseph; Ownby, Stacy L.; Huggenvik, Jodi I.; Rose, Gregory M.; Cai, Xiang; Collard, Michael W.] So Illinois Univ, Sch Med, Ctr Integrated Res Cognit & Neural Sci, Carbondale, IL 62901 USA.
[Vergult, Sarah; de Rocker, Nina; Willaert, Andy; Menten, Bjorn] Univ Ghent, Ctr Med Genet, B-9000 Ghent, Belgium.
[Newhall, Kathryn J.; McKnight, G. Stanley] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA.
[Rose, Gregory M.] So Illinois Univ, Sch Med, Dept Anat, Carbondale, IL 62901 USA.
[Zweier, Christiane; Endele, Sabine] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany.
[van Bokhoven, Hans; de Brouwer, Arjan P. M.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6500 HB Nijmegen, Netherlands.
[Rauch, Anita] Univ Zurich, Inst Med Genet, CH-8603 Schwerzenbach, Switzerland.
[Rauch, Anita] Univ Zurich, Neurosci Ctr Zurich, CH-8603 Schwerzenbach, Switzerland.
[Rauch, Anita] Univ Zurich, Zurich Ctr Integrat Human Physiol, CH-8603 Schwerzenbach, Switzerland.
[Carvill, Gemma L.; Mefford, Heather C.] Univ Washington, Div Med Genet, Dept Pediat, Seattle, WA 98195 USA.
[Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA.
[Eichler, Evan E.] Howard Hughes Med Inst, Seattle, WA 98195 USA.
RP de Vries, BBA (reprint author), Radford Univ, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands.
EM bert.devries@radboudumc.nl
RI Rauch, Anita/C-5568-2014; Brunner, Han/C-9928-2013; Vissers,
Lisenka/A-2598-2015; Veltman, Joris/F-5128-2010; Zweier,
Christiane/F-2202-2015
OI Rauch, Anita/0000-0003-2930-3163;
FU European Commission GENCODYS [241995]; Netherlands Organisation for
Health Research and Development [917-86-319, 912-12-109, 916-12-095];
NIH [CA89438, CA137556, HD060122]; Southern Illinois University School
of Medicine; Fraternal Order of Eagles in Carbondale
FX We are grateful to the individuals involved and their parents for their
participation. We would like to thank Hanka Venselaar for the in silico
modeling of the DEAF1 mutations. This work was supported by European
Commission GENCODYS grant 241995 under the Seventh Framework Programme
(to A.T.V.v.S. and B.B.A.d.V.), Netherlands Organisation for Health
Research and Development grants 917-86-319 (to B.B.A.d.V.), 912-12-109
(to B.B.A.d.V. and J.A.V.), and 916-12-095 (to A.H.), NIH grants
CA89438, CA137556, and HD060122 (to J.I.H. and M.W.C.), funds from the
Southern Illinois University School of Medicine (to J.I.H. and M.W.C.),
and funds from the Fraternal Order of Eagles in Carbondale (to J.I.H.
and M.W.C.).
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
Barker HE, 2008, BMC DEV BIOL, V8, DOI 10.1186/1471-213X-8-94
Bottomley MJ, 2001, NAT STRUCT BIOL, V8, P626, DOI 10.1038/89675
Calabrese R, 2009, HUM MUTAT, V30, P1237, DOI 10.1002/humu.21047
Cubeddu L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039218
Czesak M, 2012, J BIOL CHEM, V287, P6615, DOI 10.1074/jbc.M111.293027
de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
Gibson TJ, 1998, TRENDS BIOCHEM SCI, V23, P242, DOI 10.1016/S0968-0004(98)01231-6
Gross CT, 1996, EMBO J, V15, P1961
Hahm KM, 2004, MOL CELL BIOL, V24, P2074, DOI 10.1128/MCB.24.5.2074-2082.2004
Huggenvik JI, 1998, MOL ENDOCRINOL, V12, P1619, DOI 10.1210/me.12.10.1619
Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
Jensik PJ, 2004, J BIOL CHEM, V279, P32692, DOI 10.1074/jbc.M400946200
Jensik PJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033404
Kateb F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054715
LeBoeuf RD, 1998, J BIOL CHEM, V273, P361, DOI 10.1074/jbc.273.1.361
Lemonde S, 2003, J NEUROSCI, V23, P8788
Li B, 2009, BIOINFORMATICS, V25, P2744, DOI 10.1093/bioinformatics/btp528
Manne U, 2001, CLIN CANCER RES, V7, P3495
Michelson RJ, 1999, J BIOL CHEM, V274, P30510, DOI 10.1074/jbc.274.43.30510
Ordureau A, 2013, J BIOL CHEM, V288, P24569, DOI 10.1074/jbc.M113.479550
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
Pollard KS, 2010, GENOME RES, V20, P110, DOI 10.1101/gr.097857.109
Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Szewczyk B, 2009, INT J NEUROPSYCHOPH, V12, P155, DOI 10.1017/S1461145708009012
Tronche F, 1999, NAT GENET, V23, P99, DOI 10.1038/12703
Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
Venselaar H, 2010, BMC BIOINFORMATICS, V11, DOI 10.1186/1471-2105-11-548
Veraksa A, 2002, GENESIS, V33, P67, DOI 10.1002/gene.10090
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Yang YP, 2013, NEW ENGL J MED, V369, P1502, DOI 10.1056/NEJMoa1306555
Yip L, 2013, J MOL CELL BIOL, V5, P99, DOI 10.1093/jmcb/mjs052
Yip LD, 2009, NAT IMMUNOL, V10, P1026, DOI 10.1038/ni.1773
Zhang JH, 2004, PHYSIOL GENOMICS, V18, P167, DOI 10.1152/physiolgenomics.00220.2003
NR 36
TC 3
Z9 3
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
EI 1537-6605
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD MAY 1
PY 2014
VL 94
IS 5
BP 649
EP 661
DI 10.1016/j.ajhg.2014.03.013
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA AG5VB
UT WOS:000335485700001
PM 24726472
ER
PT J
AU Pinto, D
Delaby, E
Merico, D
Barbosa, M
Merikangas, A
Klei, L
Thiruvahindrapuram, B
Xu, X
Ziman, R
Wang, ZZ
Vorstman, JAS
Thompson, A
Regan, R
Pilorge, M
Pellecchia, G
Pagnamenta, AT
Oliveira, B
Marshall, CR
Magalhaes, TR
Lowe, JK
Howe, JL
Griswold, AJ
Gilbert, J
Duketis, E
Dombroski, BA
De Jonge, MV
Cuccaro, M
Crawford, EL
Correia, CT
Conroy, J
Conceicao, IC
Chiocchetti, AG
Casey, JP
Cai, G
Cabrol, C
Bolshakova, N
Bacchelli, E
Anney, R
Gallinger, S
Cotterchio, M
Casey, G
Zwaigenbaum, L
Wittemeyer, K
Wing, K
Wallace, S
van Engeland, H
Tryfon, A
Thomson, S
Soorya, L
Roge, B
Roberts, W
Poustka, F
Mouga, S
Minshew, N
McInnes, LA
McGrew, SG
Lord, C
Leboyer, M
Le Couteur, AS
Kolevzon, A
Gonzalez, PJ
Jacob, S
Holt, R
Guter, S
Green, J
Green, A
Gillberg, C
Fernandez, BA
Duque, F
Delorme, R
Dawson, G
Chaste, P
Cafe, C
Brennan, S
Bourgeron, T
Bolton, PF
Bolte, S
Bernier, R
Baird, G
Bailey, AJ
Anagnostou, E
Almeida, J
Wijsman, EM
Vieland, VJ
Vicente, AM
Schellenberg, GD
Pericak-Vance, M
Paterson, AD
Parr, JR
Oliveira, G
Nurnberger, JI
Monaco, AP
Maestrini, E
Klauck, SM
Hakonarson, H
Haines, JL
Geschwind, DH
Freitag, CM
Folstein, SE
Ennis, S
Coon, H
Battaglia, A
Szatmari, P
Sutcliffe, JS
Hallmayer, J
Gill, M
Cook, EH
Buxbaum, JD
Devlin, B
Gallagher, L
Betancur, C
Scherer, SW
AF Pinto, Dalila
Delaby, Elsa
Merico, Daniele
Barbosa, Mafalda
Merikangas, Alison
Klei, Lambertus
Thiruvahindrapuram, Bhooma
Xu, Xiao
Ziman, Robert
Wang, Zhuozhi
Vorstman, Jacob A. S.
Thompson, Ann
Regan, Regina
Pilorge, Marion
Pellecchia, Giovanna
Pagnamenta, Alistair T.
Oliveira, Barbara
Marshall, Christian R.
Magalhaes, Tiago R.
Lowe, Jennifer K.
Howe, Jennifer L.
Griswold, Anthony J.
Gilbert, John
Duketis, Eftichia
Dombroski, Beth A.
De Jonge, Maretha V.
Cuccaro, Michael
Crawford, Emily L.
Correia, Catarina T.
Conroy, Judith
Conceicao, Ines C.
Chiocchetti, Andreas G.
Casey, Jillian P.
Cai, Guiqing
Cabrol, Christelle
Bolshakova, Nadia
Bacchelli, Elena
Anney, Richard
Gallinger, Steven
Cotterchio, Michelle
Casey, Graham
Zwaigenbaum, Lonnie
Wittemeyer, Kerstin
Wing, Kirsty
Wallace, Simon
van Engeland, Herman
Tryfon, Ana
Thomson, Susanne
Soorya, Latha
Roge, Bernadette
Roberts, Wendy
Poustka, Fritz
Mouga, Susana
Minshew, Nancy
McInnes, L. Alison
McGrew, Susan G.
Lord, Catherine
Leboyer, Marion
Le Couteur, Ann S.
Kolevzon, Alexander
Gonzalez, Patricia Jimenez
Jacob, Suma
Holt, Richard
Guter, Stephen
Green, Jonathan
Green, Andrew
Gillberg, Christopher
Fernandez, Bridget A.
Duque, Frederico
Delorme, Richard
Dawson, Geraldine
Chaste, Pauline
Cafe, Catia
Brennan, Sean
Bourgeron, Thomas
Bolton, Patrick F.
Boelte, Sven
Bernier, Raphael
Baird, Gillian
Bailey, Anthony J.
Anagnostou, Evdokia
Almeida, Joana
Wijsman, Ellen M.
Vieland, Veronica J.
Vicente, Astrid M.
Schellenberg, Gerard D.
Pericak-Vance, Margaret
Paterson, Andrew D.
Parr, Jeremy R.
Oliveira, Guiomar
Nurnberger, John I.
Monaco, Anthony P.
Maestrini, Elena
Klauck, Sabine M.
Hakonarson, Hakon
Haines, Jonathan L.
Geschwind, Daniel H.
Freitag, Christine M.
Folstein, Susan E.
Ennis, Sean
Coon, Hilary
Battaglia, Agatino
Szatmari, Peter
Sutcliffe, James S.
Hallmayer, Joachim
Gill, Michael
Cook, Edwin H.
Buxbaum, Joseph D.
Devlin, Bernie
Gallagher, Louise
Betancur, Catalina
Scherer, Stephen W.
TI Convergence of Genes and Cellular Pathways Dysregulated in Autism
Spectrum Disorders
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; COPY NUMBER VARIANTS; GENOME-WIDE ASSOCIATION;
FRAGILE-X-SYNDROME; INTELLECTUAL DISABILITY; STRUCTURAL VARIATION;
PHENOTYPE ONTOLOGY; DELETIONS; DUPLICATIONS; RISK
AB Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus control groups (1.41-fold, p = 1.0 x 10(-5)) and an increase in affected subjects carrying exonic pathogenic CNVs overlapping known loci associated with dominant or X-linked ASD and intellectual disability (odds ratio = 12.62, p = 2.7 x 10(-15), similar to 3% of ASD subjects). Pathogenic CNVs, often showing variable expressivity, included rare de novo and inherited events at 36 loci, implicating ASD-associated genes (CHD2, HDAC4, and GDI1) previously linked to other neurodevelopmental disorders, as well as other genes such as SETD5, MIR137, and HDAC9. Consistent with hypothesized gender-specific modulators, females with ASD were more likely to have highly penetrant CNVs (p = 0.017) and were also overrepresented among subjects with fragile X syndrome protein targets (p = 0.02). Genes affected by de novo CNVs and/or loss-of-function single-nucleotide variants converged on networks related to neuronal signaling and development, synapse function, and chromatin regulation.
C1 [Pinto, Dalila; Barbosa, Mafalda; Cai, Guiqing; Tryfon, Ana; Soorya, Latha; McInnes, L. Alison; Kolevzon, Alexander; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[Pinto, Dalila; Barbosa, Mafalda; Xu, Xiao; Cai, Guiqing; Tryfon, Ana; Soorya, Latha; McInnes, L. Alison; Kolevzon, Alexander; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
[Pinto, Dalila; Barbosa, Mafalda; Cai, Guiqing; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
[Pinto, Dalila; Barbosa, Mafalda; Xu, Xiao; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
[Pinto, Dalila; Xu, Xiao] Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA.
[Pinto, Dalila; Kolevzon, Alexander; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
[Delaby, Elsa; Pilorge, Marion; Cabrol, Christelle; Betancur, Catalina] Inst Natl Sante & Rech Med U1130, F-75005 Paris, France.
[Delaby, Elsa; Pilorge, Marion; Cabrol, Christelle; Betancur, Catalina] CNRS, UMR 8246, F-75005 Paris, France.
[Delaby, Elsa; Pilorge, Marion; Cabrol, Christelle; Betancur, Catalina] Univ Paris 04, Univ Paris 06, Neurosci Paris Seine, F-75005 Paris, France.
[Merico, Daniele; Thiruvahindrapuram, Bhooma; Ziman, Robert; Wang, Zhuozhi; Pellecchia, Giovanna; Marshall, Christian R.; Howe, Jennifer L.; Paterson, Andrew D.; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Gen, Program Genet & Genome Biol, Toronto, ON M5G 1L7, Canada.
[Merikangas, Alison; Bolshakova, Nadia; Anney, Richard; Brennan, Sean; Gill, Michael; Gallagher, Louise] Univ Dublin Trinity Coll, Sch Med, Discipline Psychiat, Dublin 8, Ireland.
[Klei, Lambertus; Minshew, Nancy; Chaste, Pauline; Devlin, Bernie] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA.
[Vorstman, Jacob A. S.; De Jonge, Maretha V.; van Engeland, Herman] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, NL-3584 CX Utrecht, Netherlands.
[Thompson, Ann; Szatmari, Peter] McMaster Univ, Offord Ctr Child Studies, Dept Psychiat & Behav Neurosci, Hamilton, ON L8S 4K1, Canada.
[Regan, Regina; Magalhaes, Tiago R.; Casey, Jillian P.] Our Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin 12, Ireland.
[Regan, Regina; Magalhaes, Tiago R.; Conroy, Judith; Casey, Jillian P.; Green, Andrew; Ennis, Sean] Univ Coll Dublin, Sch Med & Med Sci, Acad Ctr Rare Dis, Dublin 4, Ireland.
[Pagnamenta, Alistair T.; Wing, Kirsty; Holt, Richard; Monaco, Anthony P.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
[Oliveira, Barbara; Correia, Catarina T.; Conceicao, Ines C.; Vicente, Astrid M.] Inst Nacl Saude Doutor Ricardo Jorge, P-1649016 Lisbon, Portugal.
[Oliveira, Barbara; Correia, Catarina T.; Conceicao, Ines C.; Vicente, Astrid M.] Univ Lisbon, Fac Sci, Ctr Biodivers Funct & Integrat Genom, P-1749016 Lisbon, Portugal.
[Marshall, Christian R.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON M5S 1A1, Canada.
[Lowe, Jennifer K.; Geschwind, Daniel H.] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA.
[Lowe, Jennifer K.; Geschwind, Daniel H.] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Semel Inst, David Geffen Sch Med, Los Angeles, CA 90095 USA.
[Griswold, Anthony J.; Gilbert, John; Cuccaro, Michael; Pericak-Vance, Margaret] Univ Miami, John P Hussman Inst Human Genom, Miami, FL 33136 USA.
[Griswold, Anthony J.; Gilbert, John; Cuccaro, Michael; Pericak-Vance, Margaret] Univ Miami, Dr John T Macdonald Fdn, Dept Human Genet, Miller Sch Med, Miami, FL 33136 USA.
[Duketis, Eftichia; Chiocchetti, Andreas G.; Poustka, Fritz; Freitag, Christine M.] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
[Dombroski, Beth A.; Schellenberg, Gerard D.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Crawford, Emily L.; Thomson, Susanne; Haines, Jonathan L.; Sutcliffe, James S.] Vanderbilt Univ, Ctr Human Genet Res, Vanderbilt Brain Inst, Nashville, TN 37232 USA.
[Crawford, Emily L.; Thomson, Susanne; Haines, Jonathan L.; Sutcliffe, James S.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
[Conroy, Judith] Childrens Univ Hosp Temple St, Dublin 1, Ireland.
[Bacchelli, Elena; Maestrini, Elena] Univ Bologna, Dept Pharm & Biotechnol, I-40126 Bologna, Italy.
[Gallinger, Steven] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
[Cotterchio, Michelle] Canc Care Ontario, Toronto, ON M5G 2L7, Canada.
[Casey, Graham] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA.
[Zwaigenbaum, Lonnie] Univ Alberta, Dept Pediat, Edmonton, AB T6B 2H3, Canada.
[Wittemeyer, Kerstin] Univ Birmingham, Sch Educ, Birmingham B15 2TT, W Midlands, England.
[Wallace, Simon; Bailey, Anthony J.] Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England.
[Wallace, Simon; Bailey, Anthony J.] Warneford Hosp, Oxford OX3 7JX, England.
[Roge, Bernadette] Univ Toulouse 2, Unite Rech Interdisciplinaire Octogone, Ctr Etud & Rech Psychopathol, F-31058 Toulouse, France.
[Roberts, Wendy] Hosp Sick Children, Autism Res Unit, Toronto, ON M5G 1X8, Canada.
[Mouga, Susana; Duque, Frederico; Cafe, Catia; Almeida, Joana; Oliveira, Guiomar] Ctr Hosp Coimbra, Pediat Hosp, Unidade Neurodesenvolvimento & Autismo Serv, Ctr Desenvolvimento Crianca, P-3000602 Coimbra, Portugal.
[Mouga, Susana; Duque, Frederico; Cafe, Catia; Almeida, Joana; Oliveira, Guiomar] Ctr Hosp Coimbra, Ctr Invest & Formacao Clin, Pediat Hosp, P-3000602 Coimbra, Portugal.
[Mouga, Susana; Duque, Frederico; Cafe, Catia; Almeida, Joana; Oliveira, Guiomar] Univ Coimbra, P-3000602 Coimbra, Portugal.
[Mouga, Susana; Duque, Frederico; Cafe, Catia; Almeida, Joana; Oliveira, Guiomar] Univ Coimbra, P-3000354 Coimbra, Portugal.
[Mouga, Susana; Duque, Frederico; Oliveira, Guiomar] Univ Coimbra, Univ Clin Pediat, P-3000354 Coimbra, Portugal.
[Mouga, Susana; Duque, Frederico; Oliveira, Guiomar] Univ Coimbra, Inst Biomed Imaging & Life Sci, Fac Med, P-3000354 Coimbra, Portugal.
[McGrew, Susan G.] Vanderbilt Univ, Dept Pediat, Nashville, TN 37232 USA.
[Lord, Catherine] NewYorkPresbyterian Weill Cornell Med Ctr, New York, NY 10065 USA.
[Leboyer, Marion; Delorme, Richard; Chaste, Pauline; Bourgeron, Thomas] FondaMental Fdn, F-94010 Creteil, France.
[Leboyer, Marion] Inst Natl Sante & Rech U955, F-94010 Creteil, France.
[Leboyer, Marion] Univ Paris Est, Fac Med, F-94010 Creteil, France.
[Leboyer, Marion] Henri Mondor Albert Chenevier Hosp, AP HP, Dept Psychiat, F-94010 Creteil, France.
[Le Couteur, Ann S.] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
[Gonzalez, Patricia Jimenez] Hosp Nacl Ninos Dr Carlos Saenz Herrera, Child Dev & Behav Unit, Caja Costarricense Seguro Social, San Jose, Costa Rica.
[Jacob, Suma; Guter, Stephen; Cook, Edwin H.] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA.
[Jacob, Suma] Univ Minnesota, Inst Translat Neurosci, Minneapolis, MN 55455 USA.
[Jacob, Suma] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA.
[Green, Jonathan] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester M13 9PL, Lancs, England.
[Green, Jonathan] Manchester Acad Hlth Sci Ctr, Manchester M13 9NT, Lancs, England.
[Green, Andrew; Ennis, Sean] Our Ladys Childrens Hosp, Natl Ctr Med Genet, Dublin 12, Ireland.
[Gillberg, Christopher] Univ Gothenburg, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
[Fernandez, Bridget A.] Mem Univ Newfoundland, Fac Med, Discipline Genet, St John, NF A1B 3V6, Canada.
[Delorme, Richard; Bourgeron, Thomas] Inst Pasteur, Human Genet & Cognit Funct Unit, F-75015 Paris, France.
[Delorme, Richard; Bourgeron, Thomas] Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, F-75015 Paris, France.
[Delorme, Richard] Robert Debre Hosp, AP HP, Dept Child & Adolescent Psychiat, F-75019 Paris, France.
[Dawson, Geraldine] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
[Bourgeron, Thomas] Univ Paris Diderot, Sorbonne Paris Cite, F-75013 Paris, France.
[Bolton, Patrick F.] Kings Coll London, Inst Psychiat, London SE5 8AF, England.
[Bolton, Patrick F.] South London & Maudsley Biomed Res Ctr Mental Hlt, London SES 8AF, England.
[Boelte, Sven] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
[Bernier, Raphael] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Baird, Gillian] Kings Coll London, Kings Hlth Partners, London WC2R 2L5, England.
[Anagnostou, Evdokia] Univ Toronto, Bloorview Res Inst, Toronto, ON M4G 1R8, Canada.
[Wijsman, Ellen M.] Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA.
[Wijsman, Ellen M.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Vieland, Veronica J.] Nationwide Childrens Hosp, Res Inst, Battelle Ctr Math Med, Columbus, OH 43205 USA.
[Paterson, Andrew D.] Dalla Lana Sch Publ Hlth, Toronto, ON MST 3M7, Canada.
[Parr, Jeremy R.] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
[Nurnberger, John I.] Indiana Univ Sch Med, Inst Psychiat Res, Dept Psychiat, Indianapolis, IN 46202 USA.
[Nurnberger, John I.] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
[Nurnberger, John I.] Indiana Univ Sch Med, Program Med Neurosci, Indianapolis, IN 46202 USA.
[Monaco, Anthony P.] Tufts Univ, Off President, Medford, MA 02155 USA.
[Klauck, Sabine M.] Deutsch Krebsforschungszentrum, German Canc Res Ctr, Div Mol Genome Anal, D-69120 Heidelberg, Germany.
[Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
[Hakonarson, Hakon] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
[Folstein, Susan E.] Univ Miami, Dept Psychiat, Miller Sch Med, Div Child & Adolescent Psychiat, Miami, FL 33136 USA.
[Coon, Hilary] Univ Utah, Sch Med, Dept Psychiat, Utah Autism Res Program, Salt Lake City, UT 84108 USA.
[Battaglia, Agatino] Stella Maris Clin Res Inst Child & Adolescent Neu, I-56128 Pisa, Italy.
[Hallmayer, Joachim] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
RP Betancur, C (reprint author), Inst Natl Sante & Rech Med U1130, F-75005 Paris, France.
EM catalina.betancur@inserm.fr; stephen.scherer@sickkids.ca
RI Gallinger, Steven/E-4575-2013; Scherer, Stephen /B-3785-2013; Duque,
Frederico/H-3692-2014; Bailey, Anthony/J-2860-2014; Jacob,
Suma/J-7941-2013; Bolton, Patrick/E-8501-2010; Monaco,
Anthony/A-4495-2010; Sutcliffe, James/C-1348-2012
OI Scherer, Stephen /0000-0002-8326-1999; Duque,
Frederico/0000-0001-5684-1472; Bailey, Anthony/0000-0003-4257-972X;
Jacob, Suma/0000-0001-7434-7398; Bolton, Patrick/0000-0002-5270-6262;
Monaco, Anthony/0000-0001-7480-3197; Sutcliffe,
James/0000-0001-5200-6007
FU Autism Speaks (USA); Health Research Board (Ireland) [AUT/2006/1,
AUT/2006/2, PD/2006/48]; Medical Research Council (UK); Hilibrand
Foundation (USA); Genome Canada; Canadian Institutes of Health Research
(CIHR); Brain & Behavior Research Foundation; Ontario Genomics Institute
FX The authors thank the main funders of the Autism Genome Project: Autism
Speaks (USA), the Health Research Board (Ireland; AUT/2006/1,
AUT/2006/2, PD/2006/48), the Medical Research Council (UK), the
Hilibrand Foundation (USA), Genome Canada, the Ontario Genomics
Institute, and the Canadian Institutes of Health Research (CIHR).
Additional support for individual groups is shown in the Supplemental
Acknowledgments. D.P. is the Abraham & Mildred Goldstein Seaver Center
Faculty Fellow, J.D.B. holds the G. Harold and Leila Y. Mathers
Professorship, C.B. is the recipient of a NARSAD Independent
Investigator Grant from the Brain & Behavior Research Foundation, and
S.W.S. holds the GlaxoSmithKline-CIHR Pathfinder Chair in Genome
Sciences at the University of Toronto and The Hospital for Sick
Children. E.H.C. is an advisor of Seaside Therapeutics, G.D. is a member
of the Scientific Advisory Board at Integragen Inc., and S.W.S. is an
advisor to Population Diagnostics and advisor and founder of YouNique
Genomics. D.P., P.S J.S.S., J.H., M.G., E.H.C., J.D.B., B.D., L.G.,
C.B., and S.W.S were leading contributors to the design and analysis of
this study, and D.P., E. Delaby, D.M., M.B., J.D.B., B.D., L.G., C.B.,
and S.W.S wrote the manuscript.
CR Albertinazzi C, 1998, J CELL BIOL, V142, P815, DOI 10.1083/jcb.142.3.815
Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Ascano M, 2012, NATURE, V492, P382, DOI 10.1038/nature11737
Bayes A, 2011, NAT NEUROSCI, V14, P19, DOI 10.1038/nn.2719
Bena F, 2013, AM J MED GENET B, V162B, P388, DOI 10.1002/ajmg.b.32148
Berryer MH, 2013, HUM MUTAT, V34, P385, DOI 10.1002/humu.22248
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
Buxbaum JD, 2012, NEURON, V76, P1052, DOI 10.1016/j.neuron.2012.12.008
Carter MT, 2011, CLIN GENET, V80, P435, DOI 10.1111/j.1399-0004.2010.01578.x
Carvill GL, 2013, NAT GENET, V45, P825, DOI 10.1038/ng.2646
Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
Darnell JC, 2011, CURR OPIN GENET DEV, V21, P465, DOI 10.1016/j.gde.2011.05.002
Day JJ, 2011, NEURON, V70, P813, DOI 10.1016/j.neuron.2011.05.019
de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Figueiredo JC, 2011, CANCER EPIDEM BIOMAR, V20, P758, DOI 10.1158/1055-9965.EPI-10-0675
Fox CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002695
Gai X, 2012, MOL PSYCHIATR, V17, P402, DOI 10.1038/mp.2011.10
Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
Gross C, 2010, J NEUROSCI, V30, P10624, DOI 10.1523/JNEUROSCI.0402-10.2010
Huang N, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001154
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
Kearney HM, 2011, GENET MED, V13, P680, DOI 10.1097/GIM.0b013e3182217a3a
Khurana E, 2013, PLOS COMPUT BIOL, V9, DOI 10.1371/journal.pcbi.1002886
Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Moreno-De-Luca D, 2013, MOL PSYCHIATR, V18, P1090, DOI 10.1038/mp.2012.138
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Newcomb PA, 2007, CANCER EPIDEM BIOMAR, V16, P2331, DOI 10.1158/1055-9965.EPI-07-0648
Noor A, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001267
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Pinto D, 2011, NAT BIOTECHNOL, V29, P512, DOI 10.1038/nbt.1852
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Robinson EB, 2013, P NATL ACAD SCI USA, V110, P5258, DOI 10.1073/pnas.1211070110
Robinson PN, 2008, AM J HUM GENET, V83, P610, DOI 10.1016/j.ajhg.2008.09.017
Rossin EJ, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001273
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
Schoch S, 2002, NATURE, V415, P321, DOI 10.1038/415321a
Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
Smith CL, 2005, GENOME BIOL, V6, DOI 10.1186/gb-2004-6-1-r7
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stankiewicz P, 2012, HUM MUTAT, V33, P165, DOI 10.1002/humu.21614
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
The Schizophrenia Psychiatric Genome-Wide Association Study C, 2011, NAT GENET, V43, P969
Tropeano M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061365
Turner DJ, 2008, NAT GENET, V40, P90, DOI 10.1038/ng.2007.40
Urraca N, 2013, AUTISM RES, V6, P268, DOI 10.1002/aur.1284
Vandewalle J, 2009, AM J HUM GENET, V85, P809, DOI 10.1016/j.ajhg.2009.10.019
Willemsen MH, 2011, J MED GENET, V48, P810, DOI 10.1136/jmedgenet-2011-100294
Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
NR 64
TC 51
Z9 52
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
EI 1537-6605
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD MAY 1
PY 2014
VL 94
IS 5
BP 677
EP 694
DI 10.1016/j.ajhg.2014.03.018
PG 18
WC Genetics & Heredity
SC Genetics & Heredity
GA AG5VB
UT WOS:000335485700003
PM 24768552
ER
PT J
AU Sanz-Cortes, M
Egana-Ugrinovic, G
Zupan, R
Figueras, F
Gratacos, E
AF Sanz-Cortes, Magdalena
Egana-Ugrinovic, Gabriela
Zupan, Rudolf
Figueras, Francesc
Gratacos, Eduard
TI Brainstem and cerebellar differences and their association with
neurobehavior in term small-for-gestational-age fetuses assessed by
fetal MRI
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE brain stem; cerebellum; fetal MRI; intrauterine growth restriction
(IUGR); small-for-gestational-age (SGA)
ID INTRAUTERINE GROWTH-RESTRICTION; BEHAVIORAL-ASSESSMENT SCALE; AUTISM
SPECTRUM DISORDER; PRETERM INFANTS; CHILDREN; BIRTH; HIPPOCAMPUS; SIZE;
NEUROSONOGRAPHY; INTERVENTIONS
AB OBJECTIVE: We tested the hypothesis whether small-for-gestational-age (SGA) fetuses have different brain stem and cerebellar morphometry when compared with appropriate-for-gestational-age (AGA) fetuses and whether the differences in these structures were associated with their neonatal neurobehavior.
STUDY DESIGN: Magnetic resonance imaging was performed on 51 SGA fetuses and 47 AGA fetuses at 37 weeks' gestation. Pontine width, medullar width, vermian width and height, cerebellar primary fissure's depth, and cerebellar volume were measured and corrected by biparietal diameter and cerebellar volume by total intracranial volume. Ratios were compared between cases and control subjects. The association between morphometric differences and neuro-behavioral outcome in SGAs was tested.
RESULTS: Brainstem and cerebellar ratios were significantly larger in SGA fetuses: pontine width, SGA 0.143 +/- 0.01 vs AGA 0.135 +/- 0.01 (P < .01); medullar width, SGA 0.088 +/- 0.01 vs AGA 0.083 +/- 0.01 (P = .03); vermian width, SGA 0.181 +/- 0.03 vs AGA 0.162 +/- 0.02 (P < .01); vermian height, SGA 0.235 +/- 0.03 vs AGA 0.222 +/- 0.01 (P < .01); cerebellar volume, SGA 0.042 +/- 0.01 vs AGA 0.038 +/- 0.00 (P = .04); with deeper cerebellar primary fissure in SGAs, SGA 0.041 +/- 0.01 vs AGA 0.035 +/- 0.01 (P = .01). Medullar, cerebellar biometries, and volumetry were significantly associated with different Neonatal Behavioral Assessment Scale cluster scores in SGA infants.
CONCLUSION: Brain stem and cerebellar morphometric measurements are significantly different in term SGA fetuses, which are associated significantly with their neurobehavioral outcome. This finding supports the existence of brain microstructural changes in SGA fetuses and lays the basis for potential image biomarkers to detect fetuses who are at risk.
C1 [Sanz-Cortes, Magdalena] Univ Barcelona, Hosp Clin, ICGON, Dept Maternal Fetal Med, Barcelona, Spain.
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Fetal & Perinatal Med Res Grp, Barcelona, Spain.
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Barcelona, Spain.
RP Sanz-Cortes, M (reprint author), Univ Barcelona, Hosp Clin, ICGON, Dept Maternal Fetal Med, Barcelona, Spain.
FU Cerebra Foundation for the Brain-Injured Child, Carmarthen, Wales, UK;
Obra Social "La Caixa"; Fundacion Dexeus, Barcelona, Spain; Rio Hortega
postdoctoral fellowship (Spain) [CM10/00222]; CONICYT [72120071]
FX Supported by grants from the Cerebra Foundation for the Brain-Injured
Child, Carmarthen, Wales, UK, and Obra Social "La Caixa" and Fundacion
Dexeus, Barcelona, Spain; a Rio Hortega postdoctoral fellowship (Spain;
CM10/00222; M. S.-C.); and grant no. 72120071 from CONICYT (Chile;
PFCHA/Doctorado al Extranjero 4a Convocatoria; G.E.-U.).
CR American College of Obstetricians and Gynecologists Committee on Obstetric Practice., 1997, INT J GYNECOL OBSTET, V59, P269
American Institute of Ultrasound in Medicine, 2010, J ULTRAS MED, V29, P151
[Anonymous], 2007, ULTRASOUND OBSTET GY, V29, P109
ARDUINI D, 1990, J PERINAT MED, V18, P165, DOI 10.1515/jpme.1990.18.3.165
Baillieux H, 2008, CLIN NEUROL NEUROSUR, V110, P763, DOI 10.1016/j.clineuro.2008.05.013
Batalle D, 2012, NEUROIMAGE, V60, P1352, DOI 10.1016/j.neuroimage.2012.01.059
Bernstein IM, 2000, AM J OBSTET GYNECOL, V182, P198, DOI 10.1016/S0002-9378(00)70513-8
Bolduc ME, 2011, DEV MED CHILD NEUROL, V53, P409, DOI 10.1111/j.1469-8749.2011.03929.x
Brazelton TB, 1995, CLIN DEV MED
Canals J, 2011, ACTA PAEDIATR, V100, P1331, DOI 10.1111/j.1651-2227.2011.02306.x
Moragas CC, 2007, PSICOTHEMA, V19, P140
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
Egana-Ugrinovic G, 2013, AM J OBSTET GYNECOL, V209
Esteban FJ, 2010, NEUROIMAGE, V53, P1225, DOI 10.1016/j.neuroimage.2010.07.019
Figueras F, 2008, EUR J OBSTET GYN R B, V136, P20, DOI 10.1016/j.ejogrb.2006.12.015
Figueras F, 2009, PEDIATRICS, V124, pE934, DOI 10.1542/peds.2008-3346
Gardosi J, 2009, BEST PRACT RES CL OB, V23, P741, DOI 10.1016/j.bpobgyn.2009.09.001
Ginath S, 2013, J MATERN-FETAL NEO M, V26, P757, DOI 10.3109/14767058.2012.755508
Herschkowitz N, 1997, NEUROPEDIATRICS, V28, P296, DOI 10.1055/s-2007-973720
Howells FM, 2012, METAB BRAIN DIS, V27, P267, DOI 10.1007/s11011-012-9287-9
Isaacs EB, 2010, PEDIATR RES, V67, P357, DOI 10.1203/PDR.0b013e3181d026da
Knickmeyer RC, 2008, J NEUROSCI, V28, P12176, DOI 10.1523/JNEUROSCI.3479-08.2008
Lackman F, 2001, AM J OBSTET GYNECOL, V185, P674, DOI 10.1067/mob.2001.116686
Leitner Y, 2007, J CHILD NEUROL, V22, P580, DOI 10.1177/0883073807302605
Limperopoulos C, 2009, PEDIATR NEUROL, V41, P1, DOI 10.1016/j.pediatrneurol.2009.02.007
Lodygensky GA, 2008, PEDIATR RES, V63, P438, DOI 10.1203/PDR.0b013e318165c005
Lundqvist-Persson C, 2001, ACTA PAEDIATR, V90, P345, DOI 10.1080/080352501300067794
Mallard C, 2000, NEUROSCIENCE, V100, P327, DOI 10.1016/S0306-4522(00)00271-2
Manto MU, 2012, FRONT NEUROANAT, V6, DOI 10.3389/fnana.2012.00001
Maulik PK, 2009, J PERINATOL, V29, P531, DOI 10.1038/jp.2009.42
McCowan LME, 2002, AM J OBSTET GYNECOL, V186, P1069, DOI 10.1067/mob.2002.122292
Moore GS, 2012, AM J OBSTET GYNECOL, V206, DOI [10.1016/j.ajog.2012.01.044, DOI 10.1016/J.AJOG.2012.01.044]
Noble Y, 2011, DEV MED CHILD NEUROL, V54, P129, DOI DOI 10.1111/J.1469-8749.2010.03903X
Padilla N, 2011, BRAIN RES, V1382, P98, DOI 10.1016/j.brainres.2011.01.032
Pae EK, 2011, INT J DEV NEUROSCI, V29, P819, DOI 10.1016/j.ijdevneu.2011.09.003
Palmen SJMC, 2005, PSYCHOL MED, V35, P561, DOI 10.1017/S0033291704003496
Radulescu E, 2012, PHARMACOGENOMICS J, V13, P70
Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
ROBINSON HP, 1975, BRIT J OBSTET GYNAEC, V82, P702, DOI 10.1111/j.1471-0528.1975.tb00710.x
Royal College of Obstetrics and Gynaecology, 2002, INV MAN SMALL FOR GE
Sagiv SK, 2008, ENVIRON HEALTH PERSP, V116, P666, DOI 10.1289/ehp.10553
Sanz-Cortes M, 2013, FETAL DIAGN THER, V33, P122, DOI 10.1159/000346566
Sanz-Cortes M, 2010, ULTRASOUND OBST GYN, V36, P159, DOI 10.1002/uog.7724
Sterley TL, 2013, BRAIN RES, V1497, P23, DOI 10.1016/j.brainres.2012.12.029
Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272
Swinny JD, 2010, INT J NEUROPSYCHOPH, V13, P515, DOI 10.1017/S146114570999037X
TimorTritsch IE, 1996, ULTRASOUND OBST GYN, V8, P42, DOI 10.1046/j.1469-0705.1996.08010042.x
Vanderveen JA, 2009, J PERINATOL, V29, P343, DOI 10.1038/jp.2008.229
NR 49
TC 0
Z9 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD MAY
PY 2014
VL 210
IS 5
AR 452.e1
DI 10.1016/j.ajog.2013.12.008
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AG6EF
UT WOS:000335510700018
PM 24315862
ER
PT J
AU Milosavljevic, N
Monet, M
Lena, I
Brau, F
Lacas-Gervais, S
Feliciangeli, S
Counillon, L
Poet, M
AF Milosavljevic, Nina
Monet, Michael
Lena, Isabelle
Brau, Frederic
Lacas-Gervais, Sandra
Feliciangeli, Sylvain
Counillon, Laurent
Poet, Mallorie
TI The Intracellular Na+/H+ Exchanger NHE7 Effects a Na+-Coupled, but Not
K+-Coupled Proton-Loading Mechanism in Endocytosis
SO CELL REPORTS
LA English
DT Article
ID LYSOSOMAL STORAGE DISEASE; TRANS-GOLGI NETWORK; MENTAL-RETARDATION;
H+-ATPASE; PH; ENDOSOMES; CHLORIDE; SLC9A6; MUTATION; PATHWAY
AB Vesicular H+-ATPases and ClC-chloride transporters are described to acidify intracellular compartments, which also express the highly conserved Na+/H+ exchangers NHE6, NHE7, and NHE9. Mutations of these exchangers cause autism-spectrum disorders and neurodegeneration. NHE6, NHE7, and NHE9 are hypothesized to exchange cytosolic K+ for H+ and alkalinize vesicles, but this notion has remained untested in K+ because their intracellular localization prevents functional measurements. Using protonkilling techniques, we selected a cell line that expresses wild-type NHE7 at the plasma membrane, enabling measurement of the exchanger's transport parameters. We found that NHE7 transports Li+ and Na+, but not K+, is nonreversible in physiological conditions and is constitutively activated by cytosolic H+. Therefore, NHE7 acts as a proton-loading transporter rather than a proton leak. NHE7 mediates an acidification of intracellular vesicles that is additive to that of V-ATPases and that accelerates endocytosis. This study reveals an unexpected function for vesicular Na+/H+ exchangers and provides clues for understanding NHE-linked neurological disorders.
C1 [Milosavljevic, Nina; Monet, Michael; Lena, Isabelle; Counillon, Laurent; Poet, Mallorie] Univ Nice Sophia Antipolis, LP2M, CNRS UMR 7370, Fac Med, F-06107 Nice, France.
[Brau, Frederic; Feliciangeli, Sylvain] Univ Nice Sophia Antipolis, IPMC, CNRS UMR 7275, F-06560 Valbonne, France.
[Lacas-Gervais, Sandra] Univ Nice Sophia Antipolis, CCMA, Fac Sci, F-06108 Nice, France.
RP Counillon, L (reprint author), Univ Nice Sophia Antipolis, LP2M, CNRS UMR 7370, Fac Med, 28 Ave Valombrose, F-06107 Nice, France.
EM laurent.counillon@unice.fr
FU University of Nice-Sophia Antipolis; ANR (JCJC SVSE1 NHEint); Basileus
EMECW
FX This work was supported by the University of Nice-Sophia Antipolis, the
ANR (JCJC SVSE1 NHEint), and the CNRS. N.M. was funded by the Basileus
EMECW project. We thank Drs. Jacques Barhanin (LP2M CNRS-UMR 7370),
Bruno Antonny (IPMC, CNRS-UMR 7275), and Mireille Cormont (C3M INSERM-U
1065) for fruitful discussions, Dr. Ellen Van Obberghen-Schilling (IBV
CNRS-UMR 7277) for critical reading of the manuscript, and Fabien Labbal
(LP2M CNRS-UMR 7370) for assistance in cell culture.
CR Aniento F, 1996, J CELL BIOL, V133, P29, DOI 10.1083/jcb.133.1.29
CLAGUE MJ, 1994, J BIOL CHEM, V269, P21
Demaurex N, 1998, J BIOL CHEM, V273, P2044, DOI 10.1074/jbc.273.4.2044
Felbor U, 2002, P NATL ACAD SCI USA, V99, P7883, DOI 10.1073/pnas.112632299
Feliciangeli S, 2010, J BIOL CHEM, V285, P4798, DOI 10.1074/jbc.M109.078535
Franke B, 2009, HUM GENET, V126, P13, DOI 10.1007/s00439-009-0663-4
Garbern JY, 2010, BRAIN, V133, P1391, DOI 10.1093/brain/awq071
Gilfillan GD, 2008, AM J HUM GENET, V82, P1003, DOI 10.1016/j.ajhg.2008.01.013
Gu F, 2000, J BIOL CHEM, V275, P8154, DOI 10.1074/jbc.275.11.8154
Gunther W, 2003, PFLUG ARCH EUR J PHY, V445, P456, DOI 10.1007/s00424-002-0950-6
Hurtado-Lorenzo A, 2006, NAT CELL BIOL, V8, P124, DOI 10.1038/ncb1348
Jentsch TJ, 2007, J PHYSIOL-LONDON, V578, P633, DOI 10.1113/jphysiol.2006.124719
Kasper D, 2005, EMBO J, V24, P1079, DOI 10.1038/sj.emboj.7600576
Kornak U, 2000, HUM MOL GENET, V9, P2059, DOI 10.1093/hmg/9.13.2059
Lacroix L., 2004, EMBO REP, V5, P91
Lasky-Su J, 2008, AM J MED GENET B, V147B, P1355, DOI 10.1002/ajmg.b.30869
Lee JH, 2012, MAGN RESON MED, V68, P363, DOI 10.1002/mrm.24361
Lin PJC, 2005, J CELL SCI, V118, P1885, DOI 10.1242/jcs.02315
Llopis J, 1998, P NATL ACAD SCI USA, V95, P6803, DOI 10.1073/pnas.95.12.6803
Maranda B, 2001, J BIOL CHEM, V276, P18540, DOI 10.1074/jbc.M011577200
Marshansky V, 2008, CURR OPIN CELL BIOL, V20, P415, DOI 10.1016/j.ceb.2008.03.015
Meda SA, 2012, NEUROIMAGE, V60, P1608, DOI 10.1016/j.neuroimage.2011.12.076
MELLMAN I, 1992, J EXP BIOL, V172, P39
Mignot C, 2013, BRAIN DEV-JPN, V35, P172, DOI 10.1016/j.braindev.2012.03.010
Milosavljevic N, 2010, CANCER RES, V70, P7514, DOI 10.1158/0008-5472.CAN-10-1253
Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
Nakamura N, 2005, J BIOL CHEM, V280, P1561, DOI 10.1074/jbc.M410041200
Numata M, 2001, J BIOL CHEM, V276, P17387, DOI 10.1074/jbc.M101319200
Poet M, 2006, P NATL ACAD SCI USA, V103, P13854, DOI 10.1073/pnas.06061347103
POUYSSEGUR J, 1984, P NATL ACAD SCI-BIOL, V81, P4833, DOI 10.1073/pnas.81.15.4833
Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
Scott CC, 2011, BIOESSAYS, V33, P103, DOI 10.1002/bies.201000108
Stromme P, 2011, BRAIN, V134, P3369, DOI 10.1093/brain/awr250
Teter K, 1998, J BIOL CHEM, V273, P19625, DOI 10.1074/jbc.273.31.19625
Vermeulen M, 2004, J IMMUNOL, V172, P3196
Zhang LL, 2006, AM J MED GENET A, V140A, P349, DOI 10.1002/ajmg.a.31080
NR 36
TC 1
Z9 1
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD MAY
PY 2014
VL 7
IS 3
BP 689
EP 696
DI 10.1016/j.celrep.2014.03.054
PG 8
WC Cell Biology
SC Cell Biology
GA AG6WZ
UT WOS:000335560900011
PM 24767989
ER
PT J
AU Jiang-Xie, LF
Liao, HM
Chen, CH
Chen, YT
Ho, SY
Lu, DH
Lee, LJ
Liou, HH
Fu, WM
Gau, SSF
AF Jiang-Xie, Li-Feng
Liao, Hsiao-Mei
Chen, Chia-Hsiang
Chen, Yuh-Tarng
Ho, Shih-Yin
Lu, Dai-Hua
Lee, Li-Jen
Liou, Horng-Huei
Fu, Wen-Mei
Gau, Susan Shur-Fen
TI Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated
aggressive behaviors and orbitofrontal cortex deficits
SO MOLECULAR AUTISM
LA English
DT Article
DE Dlgap2; aggressive behavior; orbitofrontal cortex; autism; synapse;
mouse model
ID OBSESSIVE-COMPULSIVE DISORDER; SPECTRUM DISORDERS; SOCIAL-BEHAVIOR;
PSYCHIATRIC-DISORDERS; STRUCTURAL VARIATION; SYNAPTIC FUNCTION; INBRED
STRAINS; MOUSE; MUTATIONS; DYSFUNCTION
AB Background: As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to dysfunctions of social cognition. Dlgap2, which encodes one of the main components of scaffold proteins in postsynaptic density (PSD), has been addressed as a candidate gene in autism spectrum disorders. To elucidate the disturbance of synaptic balance arising from Dlgap2 loss-of-function in vivo, we thus generated Dlgap2(-/-) mice to investigate their phenotypes of synaptic function and social behaviors.
Methods: The creation of Dlgap2(-/-) mice was facilitated by the recombineering-based method, Cre-loxP system and serial backcross. Reversal learning in a water T-maze was used to determine repetitive behaviors. The three-chamber approach task, resident-intruder test and tube task were performed to characterize the social behaviors of mutant mice. Cortical synaptosomal fraction, Golgi-Cox staining, whole-cell patch electrophysiology and transmission electron microscopy were all applied to investigate the function and structure of synapses in the orbitofrontal cortex (OFC) of Dlgap2(-/-) mice.
Results: Dlgap2(-/-) mice displayed exacerbated aggressive behaviors in the resident-intruder task, and elevated social dominance in the tube test. In addition, Dlgap2(-/-) mice exhibited a clear reduction of receptors and scaffold proteins in cortical synapses. Dlgap2(-/-) mice also demonstrated lower spine density, decreased peak amplitude of miniature excitatory postsynaptic current and ultra-structural deficits of PSD in the OFC.
Conclusions: Our findings clearly demonstrate that Dlgap2 plays a vital role in social behaviors and proper synaptic functions of the OFC. Moreover, these results may provide valuable insights into the neuropathology of autism.
C1 [Jiang-Xie, Li-Feng; Liao, Hsiao-Mei; Chen, Chia-Hsiang; Gau, Susan Shur-Fen] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan.
[Jiang-Xie, Li-Feng; Chen, Yuh-Tarng; Lee, Li-Jen; Liou, Horng-Huei; Fu, Wen-Mei; Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Taipei, Taiwan.
[Chen, Chia-Hsiang] Chang Gung Mem Hosp Linkou, Dept Psychiat, Taoyuan, Taiwan.
[Chen, Chia-Hsiang] Chang Gung Univ, Dept & Grad Inst Biomed Sci, Taoyuan, Taiwan.
[Ho, Shih-Yin; Lu, Dai-Hua; Liou, Horng-Huei; Fu, Wen-Mei] Natl Taiwan Univ, Coll Med, Sch Med, Dept Pharmacol, Taipei 10051, Taiwan.
[Lee, Li-Jen] Natl Taiwan Univ, Coll Med, Dept Anat & Cell Biol, Taipei, Taiwan.
RP Fu, WM (reprint author), Natl Taiwan Univ Hosp, Dept Psychiat, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM wenmei@ntu.edu.tw; gaushufe@ntu.edu.tw
FU National Science Council, Taiwan [NSC 97-3112-B-002-009, NSC
98-3112-B-002-004, NSC 99-3112-B-002-036, NSC 101-2314-B-002-136-MY3];
National Taiwan University Hospital [NTUH 100-S1525]; National Taiwan
University (AIM for Top University Excellent Research Project)
[10R81918-03101R892103, 102R892103]
FX This work was supported by National Science Council, Taiwan (NSC
97-3112-B-002-009, NSC 98-3112-B-002-004, NSC 99-3112-B-002-036 and NSC
101-2314-B-002-136-MY3 to SSG), National Taiwan University Hospital
(NTUH 100-S1525 to SSG) and National Taiwan University (AIM for Top
University Excellent Research Project: 10R81918-03101R892103, 102R892103
to SSG). We thank the technical services provided by the Transgenic
Mouse Model Core Facility of the National Core Facility Program for
Biotechnology, the National Science Council and the Gene Knockout Mouse
Core Laboratory of the National Taiwan University Center of Genomic
Medicine. We would like to express our thanks to Su-Mei Lai for
assisting in creating ultrathin sections for the electron microscopy
experiments.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002
Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
Boardman L, 2011, COMPR PSYCHIAT, V52, P181, DOI 10.1016/j.comppsych.2010.05.007
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
Burguiere E, 2013, SCIENCE, V340, P1243, DOI 10.1126/science.1232380
Chamberlain SR, 2008, SCIENCE, V321, P421, DOI 10.1126/science.1154433
Chen M, 2011, J NEUROSCI, V31, P9563, DOI 10.1523/JNEUROSCI.1701-11.2011
Chien WH, 2010, CLIN GENET, V78, P449, DOI 10.1111/j.1399-0004.2010.01395.x
Chien WH, 2013, MOL AUTISM, V4, P26
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Feyder M, 2010, AM J PSYCHIAT, V167, P1508, DOI 10.1176/appi.ajp.2010.10040484
Flagel SB, 2010, NEUROPSYCHOPHARMACOL, V35, P388, DOI 10.1038/npp.2009.142
Gai X, 2012, MOL PSYCHIATR, V17, P402, DOI 10.1038/mp.2011.10
Gould GG, 2011, J NEUROCHEM, V116, P291, DOI 10.1111/j.1471-4159.2010.07104.x
Grant SGN, 2012, CURR OPIN NEUROBIOL, V22, P522, DOI 10.1016/j.conb.2012.02.002
Guariglia SR, 2013, J NEUROSCI METH, V220, P24, DOI 10.1016/j.jneumeth.2013.08.019
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kim E, 1997, J CELL BIOL, V136, P669, DOI 10.1083/jcb.136.3.669
Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453
Li JM, 2013, PSYCHIAT RES, V205, P13, DOI 10.1016/j.psychres.2012.08.014
Liu PT, 2003, GENOME RES, V13, P476, DOI 10.1101/gr.749203
Marin O, 2012, NAT REV NEUROSCI, V13, P107, DOI 10.1038/nrn3155
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
Nelson RJ, 2007, NAT REV NEUROSCI, V8, P536, DOI 10.1038/nrn2174
Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Rapin I, 2008, PEDIATR CLIN N AM, V55, P1129, DOI 10.1016/j.pcl.2008.07.005
Robb AS, 2010, DEV DISABIL RES REV, V16, P258, DOI 10.1002/ddrr.118
Robinson GE, 2008, SCIENCE, V322, P896, DOI 10.1126/science.1159277
Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
SCHNEIDER R, 1992, BEHAV NEURAL BIOL, V57, P198, DOI 10.1016/0163-1047(92)90150-3
Shang CY, 2013, PSYCHOL MED, V43, P1093, DOI 10.1017/S0033291712001869
Sheng M, 2007, ANNU REV BIOCHEM, V76, P823, DOI 10.1146/annurev.biochem.76.060805.160029
Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.00123.x
Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
Takeuchi M, 1997, J BIOL CHEM, V272, P11943, DOI 10.1074/jbc.272.18.11943
Ting JT, 2012, ANNU REV NEUROSCI, V35, P49, DOI 10.1146/annurev-neuro-062111-150442
Wang F, 2011, SCIENCE, V334, P693, DOI 10.1126/science.1209951
Welch JM, 2004, J COMP NEUROL, V472, P24, DOI 10.1002/cne.20060
Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104
Wendland JR, 2009, MOL PSYCHIATR, V14, P6
Wilson E.O., 2000, SOCIOBIOLOGY NEW SYN
Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
Wu K, 2013, PSYCHIAT RES-NEUROIM, V211, P214, DOI 10.1016/j.pscychresns.2012.07.003
Yang M, 2011, CURR PROTOC NEUROSCI, DOI DOI 10.1002/0471142301.NS0826S56.:UNIT
Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 54
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 1
PY 2014
VL 5
AR 32
DI 10.1186/2040-2392-5-32
PG 13
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AG7OH
UT WOS:000335606900001
PM 25071926
ER
PT J
AU Weng, PL
Maeda, Y
Bouck, EC
AF Weng, Pei-Lin
Maeda, Yukiko
Bouck, Emily C.
TI Effectiveness of Cognitive Skills-Based Computer-Assisted Instruction
for Students With Disabilities A Synthesis
SO REMEDIAL AND SPECIAL EDUCATION
LA English
DT Article
DE technology; meta-analysis; learning outcomes; computer-assisted
instruction; research methodology
ID AUTISM SPECTRUM DISORDERS; SINGLE-SUBJECT RESEARCH; SPECIAL-EDUCATION;
INTELLECTUAL DISABILITY; LEARNING-DISABILITIES; TEACHING MACHINES;
CHILDREN; METAANALYSIS; TECHNOLOGY; INTERVENTION
AB Computer-assisted instruction (CAI) for students with disabilities can be categorized into the following categories: visual, auditory, mobile, and cognitive skills-based CAI. Cognitive-skills based CAI differs from other types of CAI largely in terms of an emphasis on instructional design features. We conducted both systematic review of literatures and meta-analysis of studies using cognitive skills-based CAI to determine the effectiveness of this technology on the learning outcomes of students with disabilities. This study also scrutinized critical instructional design features of CAI used in the synthesized studies. Results indicated (a) a moderate weighted average effect size of 0.35 for group-comparison design studies; (b) relatively large effect sizes, but inconsistent among different indices, in single-subject experimental design studies; and (c) insufficient information available on design features of the CAI used in the primary studies. Limitations, implications, and future research directions were discussed.
C1 [Weng, Pei-Lin; Maeda, Yukiko; Bouck, Emily C.] Purdue Univ, W Lafayette, IN 47907 USA.
RP Maeda, Y (reprint author), Purdue Univ, Dept Educ Studies, 100 N Univ St, W Lafayette, IN 47907 USA.
EM ymaeda@purdue.edu
CR Adams K., 2008, ASSISTIVE TECHNOLOGI, P337
American Educational. Research Association, 2006, ED RES, V35, P33, DOI DOI 10.3102/0013189X035006033
Aslan S., 2011, CONT ED TECHNOLOGY, V2, P1
Ayres KM, 2009, EDUC TRAIN DEV DISAB, V44, P493
Ayres KM, 2013, PSYCHOL SCHOOLS, V50, P259, DOI 10.1002/pits.21673
Azarmsa R., 1991, ED COMPUTING PRINCIP
BENJAMIN LT, 1988, AM PSYCHOL, V43, P703
Beretvas SN, 2008, EVIDENCE BASED COMMU, V2, P129, DOI DOI 10.1080/17489530802446302
Blok H, 2002, REV EDUC RES, V72, P101, DOI 10.3102/00346543072001101
Boone R., 1996, FOCUS AUTISM OTHER D, V11, P69
Bosseler A, 2003, J AUTISM DEV DISORD, V33, P653, DOI 10.1023/B:JADD.0000006002.82367.4f
Brock P. A., 1994, ED TECHNOLOGY CLASSR
Brown A., 2013, ED MEDIA TECHNOLOGY, V37, P55
Campbell J. M., 2010, SINGLE SUBJECT RES M, P417
Campbell JM, 2004, BEHAV MODIF, V28, P234, DOI 10.1177/0145445503259264
Campbell ML, 2009, REM SPEC EDUC, V30, P47, DOI 10.1177/0741932508315048
Chiang HY, 2010, WORK, V37, P349, DOI 10.3233/WOR-2010-1089
Christmann E., 1997, Journal of Research on Computing in Education, V29
CLARK RE, 1994, ETR&D-EDUC TECH RES, V42, P21, DOI 10.1007/BF02299088
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Cohen W, 2005, J SPEECH LANG HEAR R, V48, P715, DOI 10.1044/1092-4388(2005/049)
Coleman-Martin M. B., 2005, FOCUS AUTISM OTHER D, V20, P80, DOI [10.1177/10883576050200020401, DOI 10.1177/10883576050200020401]
Cooper H., 2009, RES SYNTHESIS METAAN, V4th
Cooper M, 2008, LECT NOTES COMPUT SC, V5105, P926, DOI 10.1007/978-3-540-70540-6_139
Cotton K., 1991, SCH IMPROVEMENT RES
Deubel P., 2003, J ED MULTIMEDIA HYPE, V12, P63
Douglas Karen H., 2012, Journal of Special Education Technology, V27
Driscoll M. P., 2005, PSYCHOL LEARNING INS
Dugan J. J., 2007, EFFECTS TECHNOLOGY B
ELKIND J, 1993, ANN DYSLEXIA, V43, P238, DOI 10.1007/BF02928184
Gagne R. M., 1991, INSTRUCTIONAL DESIGN, P211
Gagne R. M., 1985, CONDITIONS LEARNING
Gast D. L., 2010, SINGLE SUBJECT RES M, P1
Hall I, 2005, J COMPUT ASSIST LEAR, V21, P102, DOI 10.1111/j.1365-2729.2005.00118.x
Hart JE, 2012, EDUC TRAIN AUTISM DE, V47, P438
Hattie J, 2007, REV EDUC RES, V77, P81, DOI 10.3102/003465430298487
Hedges L. V., 1985, STAT MODEL METAANALY
Herbert M., 2010, DISTRICT ADM, V46, P16
Hetzroni O. E., 2005, FOCUS AUTISM OTHER D, V20, P201, DOI DOI 10.1177/10883576050200040201
Higgins JPT, 2003, BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
Higgins K, 2000, INTERV SCH CLIN, V36, P109, DOI 10.1177/105345120003600207
Irish C., 2002, J SPECIAL ED TECHNOL, V17, P29
Jimenez JE, 2003, J LEARN DISABIL-US, V36, P34, DOI 10.1177/00222194030360010501
Jowett EL, 2012, DEV NEUROREHABIL, V15, P304, DOI 10.3109/17518423.2012.682168
Judge S, 2006, J EDUC RES, V100, P52, DOI 10.3200/JOER.100.1.52-60
Judge S. L., 2001, Journal of Special Education Technology, V16
Kagohara DM, 2012, RES AUTISM SPECT DIS, V6, P304, DOI 10.1016/j.rasd.2011.05.012
Kalyuga S., 2009, COGNITIVE LOAD THEOR
KEENE S, 1987, LEARN DISABILITY Q, V10, P283, DOI 10.2307/1510602
Kim A. H., 2006, READING WRITING Q, V22, P269, DOI 10. 1080/10573560500455729
Kratochwill TR, 2013, REM SPEC EDUC, V34, P26, DOI 10.1177/0741932512452794
KULIK CLC, 1991, COMPUT HUM BEHAV, V7, P75, DOI 10.1016/0747-5632(91)90030-5
LALLY M, 1981, AM J MENT DEF, V85, P383
Lewis J., 2012, TRENDS ISSUES INSTRU, P342
LIPSEY MW, 1993, AM PSYCHOL, V48, P1181, DOI 10.1037//0003-066X.48.12.1181
Maggin DM, 2013, REM SPEC EDUC, V34, P44, DOI 10.1177/0741932511435176
Maggin DM, 2011, EXCEPTIONALITY, V19, P109, DOI 10.1080/09362835.2011.565725
Mayer RE, 2003, EDUC PSYCHOL-US, V38, P43, DOI 10.1207/S15326985EP3801_6
Mayer RE, 2011, PSYCHOL LEARN MOTIV, V55, P77, DOI 10.1016/B978-0-12-387691-1.00003-X
Mayer RE, 2003, LEARN INSTR, V13, P125, DOI 10.1016/S0959-4752(02)00016-6
Minocha Shailey, 2009, Education + Training, V51, DOI 10.1108/00400910910987192
Molenda M., 2006, ED MEDIA TECHNOLOGY, V31, P3
Morel B., 2011, HUMAN ATTENTION DIGI, P147, DOI 10.1017/CBO9780511974519.006
National Center for Learning Disabilities, 2012, LEARN DIS FAST FACTS
Newby T. J., 2010, ED TECHNOLOGY TEACHI
Newton Deborah A., 2011, Journal of Special Education Technology, V26
Okey J. R., 1991, INSTRUCTIONAL DESIGN, P193
Olive M. L., 2005, ED PSYCHOL, V25, P313, DOI DOI 10.1080/0144341042000301238
Oud Joanne, 2009, Reference Services Review, V37, DOI 10.1108/00907320910957206
Pennington R., 2011, ASSIST TECHNOL, V7, P24, DOI DOI 10.1353/ETC.2012.0022
Pennington RC, 2010, FOCUS AUTISM DEV DIS, V25, P239, DOI 10.1177/1088357610378291
Pillai V, 2008, SYSTEMATIC REV METAA
PRIDEMORE DR, 1991, ETR&D-EDUC TECH RES, V39, P27, DOI 10.1007/BF02296569
Reece G. J., 2005, RES STRATEGIES, V20, P482, DOI 10.1016/j.resstr.2006.12.018
SCHMIDT M, 1985, J SPEC EDUC, V19, P493
Seo YJ, 2010, COMPUT EDUC, V55, P363, DOI 10.1016/j.compedu.2010.02.002
Shadish W. R., 2008, EVIDENCE BASED COMMU, V2, P188, DOI DOI 10.1080/17489530802581603
Shah N., 2011, ED WEEK, V30, P1
Simpson A, 2004, EDUC TRAIN DEV DISAB, V39, P240
Skinner B. F., 1968, TECHNOLOGY TEACHING
SKINNER BF, 1958, SCIENCE, V128, P969, DOI 10.1126/science.128.3330.969
Soe K, 2000, EFFECT COMPUTER ASSI
Steele SD, 2007, J AUTISM DEV DISORD, V37, P605, DOI 10.1007/s10803-006-0202-2
Stultz S. L, 2008, THESIS REGENT U VIRG
Swanson H. L., 1999, INTERVENTIONS STUDEN
Swanson H. L., 2001, ISSUES ED, V7, P1
Swanson HL, 2003, J LEARN DISABIL-US, V36, P124, DOI 10.1177/002221940303600205
SWELLER J, 1988, COGNITIVE SCI, V12, P257, DOI 10.1207/s15516709cog1202_4
Sweller J, 2011, EXPLOR LEARN SCI, P3, DOI 10.1007/978-1-4419-8126-4
Tanis ES, 2012, INTELLECT DEV DISAB, V50, P53, DOI 10.1352/1934-9556-50.1.53
Test D. W., 2009, CAREER DEV EXCEPTION, V32, P115, DOI [10.1177/0885728809336859, DOI 10.1177/0885728809336859]
Valdez G., 1999, COMPUTER BASED TECHN
Whalen C., 2006, J SPEECH LANGUAGE PA, V1, P11
Williams D. L., 2004, Journal of Research on Technology in Education, V36
Wilson D, 2009, HDB RES SYNTHESIS ME, P159
Woodward J, 1997, REV EDUC RES, V67, P503, DOI 10.3102/00346543067004503
WOODWARD J, 1988, AM EDUC RES J, V25, P72, DOI 10.3102/00028312025001072
Xin YP, 1999, J SPEC EDUC, V32, P207
Yakubova Gulnoza, 2013, Journal of Special Education Technology, V28
Yaw J., 2011, J BEHAV ED, V20, P44, DOI [10.1007/s10864-010-9118-1, DOI 10.1007/S10864-010-9118-1]
NR 100
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0741-9325
EI 1538-4756
J9 REM SPEC EDUC
JI Remedial Spec. Educ.
PD MAY
PY 2014
VL 35
IS 3
BP 167
EP 180
DI 10.1177/0741932513514858
PG 14
WC Education, Special
SC Education & Educational Research
GA AG5JS
UT WOS:000335455900004
ER
PT J
AU McKone, E
Jeffery, L
Boeing, A
Clifford, CWG
Rhodes, G
AF McKone, Elinor
Jeffery, Linda
Boeing, Alexandra
Clifford, Colin W. G.
Rhodes, Gillian
TI Face identity aftereffects increase monotonically with adaptor extremity
over, but not beyond, the range of natural faces
SO VISION RESEARCH
LA English
DT Article
DE Face perception; Face identification; Face adaptation; Face aftereffects
ID VISUAL REPRESENTATION; FACIAL IDENTITY; ADAPTATION; PERCEPTION;
CHILDREN; SIZE; DISTINCTIVENESS; RECOGNITION; MECHANISMS; AUTISM
AB Face identity aftereffects have been used to test theories of the neural coding underlying expert face recognition. Previous studies reported larger aftereffects for adaptors that are morphed further from the average face than for adaptors closer to the average, which appeared to support opponent coding along face-identity dimensions. However, only two levels were tested and it is not clear where they were located relative to the range of naturally occurring faces. This range is of interest given the functional need of the visual system both to produce good discrimination of real everyday faces and to process novel kinds of faces that we may encounter. Here, Experiment 1 establishes the boundary of faces judged as being able to occur in everyday life. Experiment 2 then shows that aftereffects increase with adaptor extremity up to this natural-range boundary, drop significantly immediately outside the boundary, and then remain stable with no drop towards zero even for highly distorted adaptors far beyond the boundary. Computational modelling shows that this unexpected pattern cannot be explained either by a simple opponent or by a classic multichannel model. However, its qualitative features can be captured either by a combination of opponent and multichannel coding (raising the possibility that not all identity-related face dimensions are opponent coded), or by a 3-pool model containing two S-shaped-response channels and a central bell-shaped channel around the average face (raising the possibility of unexpected similarities with coding of eye and head direction). (C) 2014 Elsevier Ltd. All rights reserved.
C1 [McKone, Elinor] Australian Natl Univ, Res Sch Psychol, Canberra, ACT 0200, Australia.
[Jeffery, Linda; Boeing, Alexandra; Rhodes, Gillian] Univ Western Australia, ARC Ctr Excellence Cognit & Its Disorders, Sch Psychol, Nedlands, WA 6009, Australia.
[Clifford, Colin W. G.] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
RP McKone, E (reprint author), Australian Natl Univ, Sch Psychol, GPO Box 4, Canberra, ACT 0200, Australia.
EM elinor.mckone@anu.edu.au
FU Australian Research Council Centre of Excellence in Cognition and its
Disorders [CE110001021]; ARC Professorial Fellowship [DP0877379]; ARC
Queen Elizabeth II Fellowship [DP0984558]; Australian Research Council
Future Fellowship [FT110100150]
FX This research was supported by the Australian Research Council Centre of
Excellence in Cognition and its Disorders (CE110001021), an ARC
Professorial Fellowship to Rhodes (DP0877379), an ARC Queen Elizabeth II
Fellowship to McKone (DP0984558), and Australian Research Council Future
Fellowship to Clifford (FT110100150). We thank Eleni Avard and Stephen
Pond for assistance with testing, Stephen Pond for preparing the figures
and Mayu Nishimura and Daphne Maurer for co-creating the "Robbers Task".
Ethical approval was granted by the Human Research Ethics Committee of
the University of Western Australia.
CR Abboud H., 2008, SUPERLAB 4 0 COMPUTE
Anderson ND, 2005, VISION RES, V45, P1815, DOI 10.1016/j.visres.2005.01.012
Armann R., 2011, J VISION, V11, p[9, 1], DOI 10.1167/11.13.9
BLAKEMOR.C, 1969, SCIENCE, V166, P245, DOI 10.1126/science.166.3902.245
Busey TA, 1998, PSYCHOL SCI, V9, P476, DOI 10.1111/1467-9280.00088
Calder AJ, 2008, J EXP PSYCHOL GEN, V137, P244, DOI 10.1037/0096-3445.137.2.244
Clifford CWG, 2000, P ROY SOC B-BIOL SCI, V267, P1705
Dickinson J. E., 2010, J VISION, V10
Dickinson J. E., 2013, FRONTIERS PSYCHOL, V1
Elinor McKone, 2011, J VISION, V11, P612
Field A, 2013, DISCOVERING STAT USI
Fiorentini C, 2012, NEUROPSYCHOLOGIA, V50, P2926, DOI 10.1016/j.neuropsychologia.2012.08.019
Freiwald WA, 2009, NAT NEUROSCI, V12, P1187, DOI 10.1038/nn.2363
Hills PJ, 2010, J EXP PSYCHOL HUMAN, V36, P876, DOI 10.1037/a0018731
Jaquet E, 2008, VIS COGN, V16, P734, DOI 10.1080/13506280701350647
Jeffery L, 2013, COGNITION, V127, P258, DOI 10.1016/j.cognition.2013.01.008
Jeffery L, 2011, J EXP PSYCHOL HUMAN, V37, P1824, DOI 10.1037/a0025643
Jeffery L, 2010, J VISION, V10, DOI 10.1167/10.5.18
Johnston RA, 1997, VIS COGN, V4, P59, DOI 10.1080/713756748
Lawson R. P., 2011, J VISION, V11, P1, DOI DOI 10.1167/11.9.17.
Lawson RP, 2009, PSYCHOL SCI, V20, P363, DOI 10.1111/j.1467-9280.2009.02301.x
Leopold D. A., 2011, OXFORD HDB FACE PERC, P263
Leopold DA, 2005, P ROY SOC B-BIOL SCI, V272, P897, DOI 10.1098/rspb.2004.3022
Leopold DA, 2001, NAT NEUROSCI, V4, P89, DOI 10.1038/82947
Nishimura M, 2008, DEVELOPMENTAL SCI, V11, P620, DOI 10.1111/j.1467-7687.2008.00706.x
Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065
REGAN D, 1992, VISION RES, V32, P1845, DOI 10.1016/0042-6989(92)90046-L
Rhodes G, 2009, VISION RES, V49, P2379, DOI 10.1016/j.visres.2009.07.010
Rhodes G, 2006, VISION RES, V46, P2977, DOI 10.1016/j.visres.2006.03.002
Rhodes G., 2005, FITTING MIND WORLD A, P213, DOI DOI 10.1093/ACPROF:OSO/9780198529699.003.0009
Rhodes G, 2011, J VISION, V11, DOI 10.1167/11.1.1
Rhodes G, 2011, VISION RES, V51, P1811, DOI 10.1016/j.visres.2011.06.008
Rhodes G, 2007, VISION RES, V47, P2291, DOI 10.1016/j.visres.2007.05.012
Robbins R, 2007, J EXP PSYCHOL HUMAN, V33, P570, DOI 10.1037/0096-1523.33.3.570
Series P, 2009, NEURAL COMPUT, V21, P3271, DOI 10.1162/neco.2009.09-08-869
Susilo T, 2010, VISION RES, V50, P300, DOI 10.1016/j.visres.2009.11.016
Suzuki S., 2005, FITTING MIND WORLD A, V2, P135
Tsao DY, 2006, TRENDS COGN SCI, V10, P391, DOI 10.1016/j.tics.2006.07.009
VALENTINE T, 1991, Q J EXP PSYCHOL-A, V43, P161
VALENTINE T, 1986, PERCEPTION, V15, P525, DOI 10.1068/p150525
Van Belle G, 2010, NEUROPSYCHOLOGIA, V48, P2620, DOI 10.1016/j.neuropsychologia.2010.04.034
Webster MA, 1999, PSYCHON B REV, V6, P647, DOI 10.3758/BF03212974
Webster MA, 2011, PHILOS T R SOC B, V366, P1702, DOI 10.1098/rstb.2010.0360
Zhao C, 2011, VISION RES, V51, P2021, DOI 10.1016/j.visres.2011.07.014
Zhao L, 2001, VISION RES, V41, P2979, DOI 10.1016/S0042-6989(01)00202-4
NR 45
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0042-6989
EI 1878-5646
J9 VISION RES
JI Vision Res.
PD MAY
PY 2014
VL 98
BP 1
EP 13
DI 10.1016/j.visres.2014.01.007
PG 13
WC Neurosciences; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA AG7UJ
UT WOS:000335624000001
PM 24582798
ER
PT J
AU Zuckerman, KE
Sinche, B
Mejia, A
Cobian, M
Becker, T
Nicolaidis, C
AF Zuckerman, Katharine E.
Sinche, Brianna
Mejia, Angie
Cobian, Martiza
Becker, Thomas
Nicolaidis, Christina
TI Latino Parents' Perspectives on Barriers to Autism Diagnosis
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE autism spectrum disorder; delayed diagnosis; health services
accessibility; Hispanic Americans; qualitative research
ID SPECTRUM DISORDERS; ETHNIC DISPARITIES; EARLY INTERVENTION; HEALTH-CARE;
SERVICE USE; CHILDREN; ACCESS; AGE; IDENTIFICATION; INFORMATION
AB OBJECTIVE: Latino children are diagnosed with autism spectrum disorders (ASDs) at older ages and at the point of more severe symptoms. We sought to qualitatively describe community, family, and health care system barriers to ASD diagnosis in Latino children.
METHODS: Five focus groups and 4 qualitative interviews were conducted with 33 parents of Latino children previously diagnosed with an ASD. Participants described Latino community perceptions of autism and barriers they experienced during the diagnostic process. Sessions were audiorecorded and transcribed. Transcripts were coded by 2 researchers, and data were analyzed using thematic, analysis.
RESULTS: Parents reported low levels of ASD information and high levels of mental health and disability stigma in the Latino community. Parents had poor access to care as a result of poverty, limited English proficiency, and lack of empowerment to take advantage of services. Providers sometimes dismissed parents' concerns. The ASD diagnostic process itself was slow, inconvenient, confusing, and uncomfortable for the child. These factors led many parents to normalize their child's early behaviors, deny that a problem existed, and lose trust in the medical system.
CONCLUSIONS: Additional educational outreach to Latino families, destigmatization of ASD, streamlining the ASD diagnostic process, and providing additional support to Latino parents of at-risk children may decrease delays in ASD diagnosis among Latino, children.
C1 [Zuckerman, Katharine E.; Sinche, Brianna; Mejia, Angie; Cobian, Martiza] Oregon Hlth & Sci Univ, Child & Adolescent Hlth Measurement Initiat, Portland, OR 97239 USA.
[Zuckerman, Katharine E.] Oregon Hlth & Sci Univ, Div Gen Pediat, Portland, OR 97239 USA.
[Mejia, Angie] Syracuse Univ, Dept Sociol, Syracuse, NY USA.
[Cobian, Martiza] Univ Pacific, Dept Psychol, Hillsboro, OR USA.
[Becker, Thomas; Nicolaidis, Christina] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA.
[Nicolaidis, Christina] Oregon Hlth & Sci Univ, Dept Internal Med & Geriatr, Portland, OR 97239 USA.
[Nicolaidis, Christina] Portland State Univ, Sch Social Work, Portland, OR 97207 USA.
RP Zuckerman, KE (reprint author), Oregon Hlth & Sci Univ, 707 SW Gaines Rd,Mail Code,CDRC P, Portland, OR 97239 USA.
EM zuckerma@ohsu.edu
FU National Institute of Mental Health [1K23MH095828]; Academic Pediatric
Association/Commonwealth Fund Young Investigator Award
FX The authors would like to acknowledge Drs Ellen Lipstein and Somnath
Saha for their guidance regarding qualitative methods; Dr Christina
Bethell for material support; Teresa Gomez and the OHSU Autism Clinic
staff for help in recruitment; and Susie Larios and Erendira Valdivia
for their helpful perspectives and assistance with data analysis. Funded
by grant 1K23MH095828 from the National Institute of Mental Health
(PI=Zuckerman); partially funded by an Academic Pediatric
Association/Commonwealth Fund Young Investigator Award (PI=Zuckerman).
CR Bethell C, 2004, PEDIATRICS, V113, P1973
Blumberg SJ, 2013, CHANGES PARENT REPOR
Bornstein MH, 2004, PEDIATRICS, V114, pE557, DOI 10.1542/peds.2004-0713
Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
Broder-Fingert S, 2013, PEDIATRICS, V132, P94, DOI 10.1542/peds.2012-3886
Bussing R, 1998, SOC SCI MED, V46, P919, DOI 10.1016/S0277-9536(97)00219-0
Centers for Disease Control and Prevention, LEARN SIGNS ACT EARL
Cooper LA, COMMONWEALTH FUND RE
Flores G, 2010, PEDIATRICS, V125, pE979, DOI 10.1542/peds.2010-0188
Flores G, 2008, PEDIATRICS, V121, pE286, DOI 10.1542/peds.2007-1243
Fountain C, 2011, J EPIDEMIOL COMMUN H, V65, P503, DOI 10.1136/jech.2009.104588
Guerrero AD, 2010, MED CARE, V48, P388, DOI 10.1097/MLR.0b013e3181ca3ef7
Harstad E, 2013, ACAD PEDIATR, V13, P334, DOI 10.1016/j.acap.2013.03.010
Hill A, 2001, PSYCHOPATHOLOGY, V34, P187, DOI 10.1159/000049305
Jimenez ME, 2012, ACAD PEDIATR, V12, P551, DOI 10.1016/j.acap.2012.08.006
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Keels M, 2009, EARLY CHILD RES Q, V24, P381, DOI 10.1016/j.ecresq.2009.08.002
Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
Magana S, 2013, INTELLECT DEV DISAB, V51, P141, DOI 10.1352/1934-9556-51.3.141
Magana S, 2013, J AUTISM DEV DISORD, V43, P1098, DOI 10.1007/s10803-012-1652-3
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
Mandell DS, 2007, J AUTISM DEV DISORD, V37, P1795, DOI 10.1007/s10803-006-0314-8
MARIN G, 1987, HISPANIC J BEHAV SCI, V9, P183, DOI 10.1177/07399863870092005
Maxwell J. A., 2005, QUALITATIVE RES DESI
McKay MM, 2001, J BEHAV HEALTH SER R, V28, P475, DOI 10.1007/BF02287777
Pachter LM, 1997, ARCH PEDIAT ADOL MED, V151, P1144
Palmer RF, 2010, AM J PUBLIC HEALTH, V100, P270, DOI 10.2105/AJPH.2008.150565
Pinto-Martin JA, 2005, AM J PUBLIC HEALTH, V95, P1928, DOI 10.2105/AJPH.2004.052167
Pope C, 2000, BRIT MED J, V320, P114, DOI 10.1136/bmj.320.7227.114
SONTAG JC, 1994, EXCEPT CHILDREN, V60, P422
Torres JB, 2002, AM J ORTHOPSYCHIAT, V72, P163, DOI 10.1037/0002-9432.72.2.163
Valicenti-McDermott M, 2012, J PEDIATR-US, V161, P554, DOI 10.1016/j.jpeds.2012.05.012
Zuckerman KE, 2013, J PEDIATR-US, V162, P409, DOI 10.1016/j.jpeds.2012.07.022
Zuckerman KE, 2013, PEDIATRICS, V132, P445, DOI 10.1542/peds.2013-0383
Zuckerman KE, CLIN PEDIAT IN PRESS
NR 36
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
EI 1876-2867
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD MAY-JUN
PY 2014
VL 14
IS 3
BP 301
EP 308
DI 10.1016/j.acap.2013.12.004
PG 8
WC Pediatrics
SC Pediatrics
GA AG4CX
UT WOS:000335368000013
PM 24767783
ER
PT J
AU Thakkar, KN
Peterman, JS
Park, S
AF Thakkar, Katharine N.
Peterman, Joel S.
Park, Sohee
TI Altered Brain Activation During Action Imitation and Observation in
Schizophrenia: A Translational Approach to Investigating Social
Dysfunction in Schizophrenia
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID SCALE; PERCEPTION; MECHANISMS; DISORDERS; COGNITION; LANGUAGE; BEHAVIOR;
AUTISM; MONKEY; SELF
AB Objective: Social impairments are a key feature of schizophrenia, but their underlying mechanisms are poorly understood. Imitation, a process through which we understand the minds of others, involves the so-called mirror neuron system, a network comprising the inferior parietal lobe, inferior frontal gyrus, and posterior superior temporal sulcus. The authors examined mirror neuron system function in schizophrenia.
Method: Sixteen medicated schizophrenia patients and 16 healthy comparison subjects performed an action imitation/observation task during functional MRI. Participants saw a video of a moving,hand or spatial cue and were instructed to either execute finger movements associated with the stimulus or simply observe. Activation in the mirror neuron system was measured during imitative versus nonimitative actions and observation of a moving hand versus a moving spatial cue. These contrasts were compared across groubs.
Results: Activation in the mirror neuron system was less specific for imitation in schizophrenia. Relative to healthy subjects, patients had reduced activity in the posterior superior temporal sulcus during imitation and greater activity in the posterior superior temporal sulcus and inferior parietal lobe during nonimitative action. Patients also showed reduced activity in these regions during action observation. Mirror neuron system activation was related to symptom severity and social functioning in patients and to schizotypal syndrome in comparison subjects.
Conclusions: Given the role of the inferior parietal lobe and posterior superior temporal sulcus in imitation and social cognition, impaired imitative ability in schizophrenia may stem from faulty perception of biological. motion and transformations from perception to action. These findings extend our understanding of social dysfunction in schizophrenia.
C1 [Thakkar, Katharine N.; Peterman, Joel S.; Park, Sohee] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA.
RP Park, S (reprint author), Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA.
EM sohee.park@vanderbilt.edu
FU NIMH [R01-MH073028, F31-MH085405-01]; NARSAD; Netherlands Organization
for Scientific Research; National Center for Research Resources [UL1
RR024975-01]
FX Supported by NIMH grants R01-MH073028 to Dr. Park and F31-MH085405-01 to
Dr. Thakkar; a NARSAD Distinguished Investigator Award to Dr. Park; a
Rubicon grant from the Netherlands Organization for Scientific Research
to Dr. Thakkar; and grant UL1 RR024975-01 from the National Center for
Research Resources.
CR Andreasen NC, 1983, SCALE ASSESSMENT NEG
Andreasen NC, 1984, SCALE ASSESSMENT POS
BIRCHWOOD M, 1990, BRIT J PSYCHIAT, V157, P853, DOI 10.1192/bjp.157.6.853
Blair J. R., 1989, CLIN NEUROPSYCHOL, V3, P129, DOI DOI 10.1080/13854048908403285
Brune M, 2005, SCHIZOPHRENIA BULL, V31, P21, DOI 10.1093/schbul/sbi002
Cannon TD, 2008, ARCH GEN PSYCHIAT, V65, P28, DOI 10.1001/archgenpsychiatry.2007.3
Carruthers P, 1996, THEORIES THEORY MIND
Carter CS, 2008, BIOL PSYCHIAT, V64, P4, DOI 10.1016/j.biopsych.2008.03.020
Catmur C, 2009, PHILOS T R SOC B, V364, P2369, DOI 10.1098/rstb.2009.0048
Chambon Valerian, 2011, Brain, V134, P3728, DOI 10.1093/brain/awr306
Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893
Crow TJ, 1997, SCHIZOPHR RES, V28, P127, DOI 10.1016/S0920-9964(97)00110-2
FEINBERG I, 1978, SCHIZOPHRENIA BULL, V4, P636
Galati G, 2001, EUR J NEUROSCI, V14, P737, DOI 10.1046/j.0953-816x.2001.01674.x
Green MF, 2008, SCHIZOPHRENIA BULL, V34, P1211, DOI 10.1093/schbul/sbm145
Grossman ED, 2002, NEURON, V35, P1167, DOI 10.1016/S0896-6273(02)00897-8
Guo SX, 2014, HUM BRAIN MAPP, V35, P123, DOI 10.1002/hbm.22162
Hoffman RE, 2007, SCHIZOPHRENIA BULL, V33, P1066, DOI 10.1093/schbul/sbm079
Iacoboni M., 1999, SCIENCE, V286, P2526
Ingersoll B, 2006, J AUTISM DEV DISORD, V36, P487, DOI 10.1007/s10803-006-0089-y
Kim J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019971
Koski L, 2002, CURR OPIN NEUROL, V15, P71, DOI 10.1097/00019052-200202000-00011
Lacoboni M., 2005, CURR OPIN NEUROBIOL, V15, P632
Matthews N, 2013, SCHIZOPHRENIA BULL, V39, P94, DOI 10.1093/schbul/sbr062
MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
Nelissen K, 2011, J NEUROSCI, V31, P3743, DOI 10.1523/JNEUROSCI.4803-10.2011
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
OVERALL JE, 1962, PSYCHOL REP, V10, P799
Park S, 2008, SCHIZOPHRENIA BULL, V34, P698, DOI 10.1093/schbul/sbn048
Platek SM, 2003, COGNITIVE BRAIN RES, V17, P223, DOI 10.1016/S0926-6410(03)00109-5
RAINE A, 1991, SCHIZOPHRENIA BULL, V17, P555
Schwartz BL, 2006, PSYCHIAT RES, V145, P87, DOI 10.1016/j.psychres.2005.12.007
SELEMON LD, 1988, J NEUROSCI, V8, P4049
SMITH IM, 1994, PSYCHOL BULL, V116, P259, DOI 10.1037/0033-2909.116.2.259
Torrey EF, 2007, SCHIZOPHR RES, V97, P215, DOI 10.1016/j.schres.2007.08.023
Varcin KJ, 2010, J INT NEUROPSYCH SOC, V16, P621, DOI 10.1017/S1355617710000329
Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022
Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
NR 38
TC 8
Z9 8
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD MAY
PY 2014
VL 171
IS 5
BP 539
EP 548
DI 10.1176/appi.ajp.2013.13040498
PG 10
WC Psychiatry
SC Psychiatry
GA AG0SI
UT WOS:000335125500012
PM 24626638
ER
PT J
AU Miniscalco, C
Rudling, M
Rastam, M
Gillberg, C
Johnels, JA
AF Miniscalco, Carmela
Rudling, Maja
Rastam, Maria
Gillberg, Christopher
Johnels, Jakob Asberg
TI Imitation (rather than core language) predicts pragmatic development in
young children with ASD: a preliminary longitudinal study using CDI
parental reports
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE imitation; pre-linguistic skills; autism; development; CDI; pragmatic
ID AUTISM SPECTRUM DISORDERS; COMMUNICATIVE DEVELOPMENT INVENTORY; JOINT
ATTENTION; IMPAIRMENT; ENGAGEMENT; SKILLS; PLAY
AB Background
Research in the last decades has clearly pointed to the important role of language and communicative level when trying to understand developmental trajectories in children with autism spectrum disorders (ASD).
Aims
The purpose of this longitudinal study was to investigate whether (1) core language skills, measured as expressive vocabulary and grammar, and/or (2) pre-linguistic social-communicative skills, including gestures and imitation abilities, drive pragmatic language development in young children with ASD.
Methods & Procedures
We examined correlates and longitudinal predictors of pragmatic growth in a sample of 34 children with Autism spectrum disorder (ASD), whose parents were given parts of two MacArthur Communicative Developmental Inventories (CDI: Words & Gestures and CDI: Words & Sentences) for completion at two time points (at time 1 the mean child age was 41 months, and at time 2 it was 54 months). A novel feature in this study is that the relevant parts from both CDI forms were included at both time points, allowing us to examine whether pre-linguistic social-communication skills (e.g. imitation and gesturing) and/or core language skills (i.e. grammar and vocabulary) predict pragmatic language growth.
Outcomes & Results
The results show that basically all pre-linguistic, linguistic and pragmatic skills were associated concurrently. When controlling for possible confounders and for the autoregressive effect, imitation skills predicted pragmatic growth over time, whereas core language did not. This could only have been shown by the use of both CDI forms.
Conclusions & Implications
This preliminary study may be of both conceptual and methodological importance for research in the field of language and communication development in ASD. Imitation may play a pivotal role in the development of subsequent conversational pragmatic abilities in young children with ASD. Future research should be directed at unravelling the mechanisms underlying this association.
C1 [Miniscalco, Carmela; Gillberg, Christopher; Johnels, Jakob Asberg] Univ Gothenburg, Inst Neurosci & Physiol, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
[Miniscalco, Carmela; Johnels, Jakob Asberg] Univ Gothenburg, Inst Neurosci & Physiol, Div Speech & Language Pathol, Gothenburg, Sweden.
[Rudling, Maja; Rastam, Maria] Lund Univ, Dept Clin Sci Lund Child & Adolescent Psychiat, S-22100 Lund, Sweden.
[Johnels, Jakob Asberg] Univ Gothenburg, Dept Psychol, Gothenburg, Sweden.
RP Miniscalco, C (reprint author), Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM carmela.miniscalco@neuro.gu.se
CR Abbeduto L., 2008, REV MENTAL RETARDATI, V3, P247
Alin-kerman B., 1991, GRIFFITHS DEV SCALES
American Psychiatric Association, 1994, DSM 4 DIAGN STAT MAN, V4th
Andersson GW, 2013, SCI WORLD J, DOI 10.1155/2013/384745
Berglund E, 2000, Logoped Phoniatr Vocol, V25, P176, DOI 10.1080/140154300750067557
Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
Bloom L., 1988, LANGUAGE DISORDERS L
Bopp K. D., 2010, J CHILD LANG, V38, P485
Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
Charman T, 2010, FOLIA PHONIATR LOGO, V62, P166, DOI 10.1159/000314032
Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
Eriksson M., 2002, 17 FOU
EVANS MA, 1987, APPL PSYCHOLINGUIST, V8, P171, DOI 10.1017/S0142716400000199
FARRANT BM, 2011, FIRST LANG, V31, P23, DOI 10.1177/0142723710365431
Fenson L., 1994, MACARTHUR COMMUNICAT
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Heimann M, 2006, INFANT CHILD DEV, V15, P297, DOI 10.1002/icd.463
Hobson JA, 2013, BRIT J DEV PSYCHOL, V31, P114, DOI 10.1111/j.2044-835X.2012.02083.x
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Kantzer AK, 2013, RES DEV DISABIL, V34, P2900, DOI 10.1016/j.ridd.2013.06.016
Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
Klin A, 2000, J AUTISM DEV DISORD, V30, P163, DOI 10.1023/A:1005415823867
Lancia R., 2000, ASPERGER SYNDROME, P125
Law J, 2008, CHILD ADOL MENT H-UK, V13, P198, DOI 10.1111/j.1475-3588.2008.00503.x
Lord C., 1997, HDB AUTISM PERVASIVE
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luyster R, 2007, J SPEECH LANG HEAR R, V50, P667, DOI 10.1044/1092-4388(2007/047)
Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
Miniscalco C, 2012, RES AUTISM SPECT DIS, V6, P204, DOI 10.1016/j.rasd.2011.05.001
Moss P., 2012, CANADIAN J PSYCHIAT, V5, P275
Ninio A., 1999, HDB CHILD LANGUAGE A, P347
Norbury F. C., 2003, INT J LANG COMM DIS, V3, P287
Norbury F. C., 2004, J SPEECH LANG HEAR R, V5, P1179
Over H, 2013, CHILD DEV PERSPECT, V7, P6, DOI 10.1111/cdep.12006
Perneger TV, 1998, BRIT MED J, V316, P1236
Poon KK, 2012, J AUTISM DEV DISORD, V42, P1064, DOI 10.1007/s10803-011-1349-z
Stone W. L., 1999, J CHILD PSYCHOL PSYC, V40, P659
Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
Volden J, 2009, J AUTISM DEV DISORD, V39, P388, DOI 10.1007/s10803-008-0618-y
Wechsler D, 1999, WECHLER PRESCHOOL PR
Williamson RA, 2014, J EXP CHILD PSYCHOL, V118, P119, DOI 10.1016/j.jecp.2013.08.005
Young EC, 2005, LANG SPEECH HEAR SER, V36, P62, DOI 10.1044/0161-1461(2005/006)
NR 43
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-2822
EI 1460-6984
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD MAY
PY 2014
VL 49
IS 3
BP 369
EP 375
DI 10.1111/1460-6984.12085
PG 7
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AG0AZ
UT WOS:000335078200009
PM 24684579
ER
PT J
AU Siu, AFY
Zhou, Y
AF Siu, Angela F. Y.
Zhou, Ya
TI Behavioral Assessment of the Dysexecutive Syndrome for Children An
Examination of Clinical Utility for Children With Attention-Deficit
Hyperactivity Disorder (ADHD)
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE executive function; ecological validity; Hong Kong; assessment; ADHD
ID LATENT-VARIABLE ANALYSIS; PERFORMANCE-BASED MEASURES; AUTISM SPECTRUM
DISORDERS; EXECUTIVE FUNCTION; RATING INVENTORY; DEFICIT/HYPERACTIVITY
DISORDER; ECOLOGICAL VALIDITY; CONSTRUCT-VALIDITY; INTERFERENCE;
SUBTYPES
AB The present study evaluated the utility of the Behavioral Assessment of Dysexecutive Syndrome for Children for discerning differences in executive functioning between attention-deficit hyperactivity disorder (ADHD) children and normal controls and examined its associations with real-life executive function as rated by parent reports on the Dysexecutive Questionnaire for Children. Sixty-three children diagnosed with ADHD and 60 normal healthy peers were recruited for this study. All participants completed the Behavioral Assessment of Dysexecutive Syndrome for Children, while their parents completed the Dysexecutive Questionnaire for Children. Results revealed that the ADHD group exhibited significantly poorer performance than the controls on 3 subtests of the Behavioral Assessment of Dysexecutive Syndrome for Children (ie, Playing Cards Test, Water Test, and Zoo Map Test 2), as well as on the total Dysexecutive Questionnaire for Children. Significant correlation was found between the total Dysexecutive Questionnaire for Children and the 6-Part Test. Findings suggested that some subtests of the Behavioral Assessment of Dysexecutive Syndrome for Children were particularly useful for detecting real-life executive dysfunction in ADHD. Yet, further studies are needed to provide extended validity data.
C1 [Siu, Angela F. Y.; Zhou, Ya] Chinese Univ Hong Kong, Dept Educ Psychol, Shatin, Hong Kong, Peoples R China.
RP Siu, AFY (reprint author), Chinese Univ Hong Kong, Dept Educ Psychol, Shatin, Hong Kong, Peoples R China.
EM afysiu@cuhk.edu.hk
CR Amanzio M, 2008, BRAIN LANG, V107, P1, DOI 10.1016/j.bandl.2007.08.003
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
Baron IS, 2007, CHILD NEUROPSYCHOL, V13, P539, DOI 10.1080/09297040601112781
Bodnar LE, 2007, CHILD NEUROPSYCHOL, V13, P345, DOI 10.1080/09297040600899867
Brown T. E., 2006, INT J DISABIL DEV ED, V53, P35, DOI DOI 10.1080/10349120500510024
Burgess PW, 2009, RESTOR NEUROL NEUROS, V27, P493, DOI 10.3233/RNN-2009-0511
Burgess PW, 2006, J INT NEUROPSYCH SOC, V12, P194, DOI 10.1017/S135561770606310
Chan AS, 2009, CLIN NEUROPHYSIOL, V120, P1107, DOI 10.1016/j.clinph.2009.04.002
Chaytor N, 2006, ARCH CLIN NEUROPSYCH, V21, P217, DOI 10.1016/j.acn.2005.12.002
Chhabildas N, 2001, J ABNORM CHILD PSYCH, V29, P529, DOI 10.1023/A:1012281226028
Collette F, 2005, HUM BRAIN MAPP, V25, P409, DOI 10.1002/hbm.20118
Emslie H., 2003, BEHAV ASSESSMENT DYS
Engel-Yeger B, 2009, NEUROPSYCHOL REHABIL, V19, P662, DOI 10.1080/09602010802622730
Eriksen C. W., 1995, VIS COGN, V2, P101, DOI DOI 10.1080/13506289508401726
Friedman NP, 2004, J EXP PSYCHOL GEN, V133, P101, DOI 10.1037/0096-3445.133.1.101
Garon N, 2008, PSYCHOL BULL, V134, P31, DOI 10.1037/0033-2909.134.1.31
Geisinger KF, 1994, PSYCHOL ASSESSMENT, V6, P304, DOI DOI 10.1037/1040-3590.6.4.304
Geurts HM, 2005, ARCH CLIN NEUROPSYCH, V20, P457, DOI 10.1016/j.acn.2004.11.001
GEVINS A, 1993, ELECTROEN CLIN NEURO, V87, P128, DOI 10.1016/0013-4694(93)90119-G
Gilbert SJ, 2008, CURR BIOL, V18, pR110, DOI 10.1016/j.cub.2007.12.014
Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504
Gioia GA, 2000, CHILD NEUROPSYCHOL, V6, P235, DOI 10.1076/chin.6.3.235.3152
Heaton S. K., 1993, WISCONSIN CARD SORTI
Hervey AS, 2004, NEUROPSYCHOLOGY, V18, P485, DOI 10.1037/0894-4105.18.3.485
Houghton S, 1999, J CHILD NEUROL, V14, P801, DOI 10.1177/088307389901401206
Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
Jonsdottir S, 2006, ARCH CLIN NEUROPSYCH, V21, P383, DOI 10.1016/j.acn.2006.05.003
Kamei S, 2008, MOVEMENT DISORD, V23, P566, DOI 10.1002/mds.21890
Katz N, 2007, NEUROPSYCHOL REHABIL, V17, P192, DOI 10.1080/09602010600685053
Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
Leark RA, 2007, TOVA PROFESSIONAL MA
Lehto JE, 2003, BRIT J DEV PSYCHOL, V21, P59, DOI 10.1348/026151003321164627
Logan GD, 1994, INHIBITORY PROCESSES, P189
Mangeot S, 2002, CHILD NEUROPSYCHOL, V8, P271, DOI 10.1076/chin.8.4.271.13503
McAuley T, 2010, J INT NEUROPSYCH SOC, V16, P495, DOI 10.1017/S1355617710000093
McCandless Stephen, 2007, J Atten Disord, V10, P381, DOI 10.1177/1087054706292115
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
Nigg JT, 2002, J AM ACAD CHILD PSY, V41, P59, DOI 10.1097/00004583-200201000-00012
Norman D., 1986, CONSCIOUSNESS SELF R, V4, P1
Paelecke-Habermann Y, 2005, J AFFECT DISORDERS, V89, P125, DOI 10.1016/j.jad.2005.09.006
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
ROGERS RD, 1995, J EXP PSYCHOL GEN, V124, P207, DOI 10.1037//0096-3445.124.2.207
Roth RM, 2005, BEHAV RATING INVENTO
Royall DR, 2002, J NEUROPSYCH CLIN N, V14, P377, DOI 10.1176/appi.neuropsych.14.4.377
SHALLICE T, 1982, PHILOS T ROY SOC B, V298, P199, DOI 10.1098/rstb.1982.0082
Shimoni M, 2012, RES DEV DISABIL, V33, P858, DOI 10.1016/j.ridd.2011.12.014
SPECTOR A, 1976, AM J PSYCHOL, V89, P669, DOI 10.2307/1421465
Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/h0054651
Suchy Y, 2009, ANN BEHAV MED, V37, P106, DOI 10.1007/s12160-009-9097-4
Tolan GA, 1999, INT J PSYCHOL, V34, P285
Toplak ME, 2013, J CHILD PSYCHOL PSYC, V54, P131, DOI 10.1111/jcpp.12001
DeSchepper B, 1996, J EXP PSYCHOL LEARN, V22, P27, DOI 10.1037/0278-7393.22.1.27
Verdejo-Garcia A, 2007, PSYCHOPHARMACOLOGY, V190, P517, DOI 10.1007/s00213-006-0632-8
Vriezen ER, 2002, CHILD NEUROPSYCHOL, V8, P296, DOI 10.1076/chin.8.4.296.13505
White SJ, 2009, AUTISM RES, V2, P138, DOI 10.1002/aur.78
Willcutt EG, 2005, DEV NEUROPSYCHOL, V27, P35, DOI 10.1207/s15326942dn2701_3
Willcutt EG, 2005, BIOL PSYCHIAT, V57, P1336, DOI 10.1016/j.biopsych.2005.02.006
Willner P, 2010, J INTELL DISABIL RES, V54, P366, DOI 10.1111/j.1365-2788.2010.01249.x
Wilson BA, 1998, NEUROPSYCHOL REHABIL, V8, P213
Wilson B.A., 1996, BEHAV ASSESSMENT DYS
Wood RL, 2006, ARCH CLIN NEUROPSYCH, V21, P429, DOI 10.1016/j.acn.2005.06.014
NR 63
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
EI 1708-8283
J9 J CHILD NEUROL
JI J. Child Neurol.
PD MAY
PY 2014
VL 29
IS 5
BP 608
EP 616
DI 10.1177/0883073813516191
PG 9
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA AG0FJ
UT WOS:000335090400006
PM 24453147
ER
PT J
AU Marques, F
Brito, MJ
Conde, M
Pinto, M
Moreira, A
AF Marques, Filipa
Brito, Maria Joao
Conde, Marta
Pinto, Monica
Moreira, Ana
TI Autism Spectrum Disorder Secondary to Enterovirus Encephalitis
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE children; enterovirus; autism spectrum disorder; encephalitis
ID HERPES-SIMPLEX ENCEPHALITIS; CENTRAL-NERVOUS-SYSTEM; PCR ASSAY;
INFECTIONS; CHILDHOOD; MENINGITIS; DIAGNOSIS; SYMPTOMS; CHILDREN; COHORT
AB Millions of children are infected by enteroviruses each year, usually exhibiting only mild symptoms. Nevertheless, these viruses are also associated with severe and life-threatening infections, such as meningitis and encephalitis. We describe a 32-month-old patient with enteroviral encephalitis confirmed by polymerase chain reaction in cerebrospinal fluid, with unfavorable clinical course with marked developmental regression, autistic features, persistent stereotypes and aphasia. She experienced slow clinical improvement, with mild residual neurologic and developmental deficits at follow-up. Viral central nervous system infections in early childhood have been associated with autism spectrum disorders but the underlying mechanisms are still poorly understood. This case report is significant in presenting a case of developmental regression with autistic features and loss of language improving on follow-up. To our knowledge, this is the first published report of enterovirus encephalitis leading to an autism spectrum disorder.
C1 [Marques, Filipa; Brito, Maria Joao; Conde, Marta] Ctr Hosp Lisboa Cent EPE, Hosp Dona Estefania, Infect Dis Unit, P-1169045 Lisbon, Portugal.
[Pinto, Monica] Ctr Hosp Lisboa Cent EPE, Hosp Dona Estefania, Child Dev Ctr, P-1169045 Lisbon, Portugal.
[Moreira, Ana] Ctr Hosp Lisboa Cent EPE, Hosp Dona Estefania, Paediat Neurol Unit, P-1169045 Lisbon, Portugal.
RP Marques, F (reprint author), Ctr Hosp Lisboa Cent EPE, Hosp Dona Estefania, Infect Dis Unit, Rua Jacinto Marto, P-1169045 Lisbon, Portugal.
EM filipa3marques@gmail.com
CR Acharya VZ, 2001, J CHILD NEUROL, V16, P864, DOI 10.1177/08830738010160111403
Atladottir HO, 2010, ARCH PEDIAT ADOL MED, V164, P470, DOI 10.1001/archpediatrics.2010.9
Chang L, 2007, NEW ENGL J MED, V356, P1226, DOI 10.1056/NEJMoa065954
Croen L. A., 2007, PEDIATRICS, V119, P61
Dalman C, 2008, AM J PSYCHIAT, V165, P59
DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777
Fowlkes AL, 2008, J INFECT DIS, V198, P1685, DOI 10.1086/592988
Gau SSF, 2008, PEDIATRICS, V122, pE452, DOI 10.1542/peds.2007-3799
GHAZIUDDIN M, 1992, J AUTISM DEV DISORD, V22, P107, DOI 10.1007/BF01046406
Ghaziuddin M, 2002, EUR CHILD ADOLES PSY, V11, P142, DOI 10.1007/s00787-002-0271-5
GILLBERG C, 1986, J AUTISM DEV DISORD, V16, P369, DOI 10.1007/BF01531665
Jang S, 2012, NEURORADIOLOGY, V54, P239, DOI 10.1007/s00234-011-0921-8
Libbey JE, 2005, J NEUROVIROL, V11, P1, DOI 10.1080/13550280590900553
Manzi B, 2008, J CHILD NEUROL, V23, P307, DOI 10.1177/0883073807308698
Noordhoek GT, 2008, J CLIN VIROL, V41, P75, DOI 10.1016/j.jcv.2007.09.011
ROTBART HA, 1995, CLIN INFECT DIS, V20, P971
Sapkal GN, 2009, EMERG INFECT DIS, V15, P295, DOI 10.3201/eid1502.080865
Sawyer MH, 2002, SEMIN PEDIAT INFECT, V13, P44
Schiff M, 2010, ARCH PEDIATRIE, V17, P802, DOI 10.1016/S0929-693X(10)70119-6
Shen WC, 1999, AM J NEURORADIOL, V20, P1889
Steiner I, 2005, EUR J NEUROL, V12, P331, DOI 10.1111/j.1468-1331.2005.01126.x
Stellrecht KA, 2000, J CLIN VIROL, V17, P143, DOI 10.1016/S1386-6532(00)00082-2
Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
van Vliet KE, 1998, J CLIN MICROBIOL, V36, P2652
Wakamoto H, 2000, PEDIATR NEUROL, V23, P429, DOI 10.1016/S0887-8994(00)00206-X
Wang SM, 2012, CLIN DEV IMMUNOL, DOI 10.1155/2012/876241
Yang Tsou-Tong, 2005, Journal of Microbiology Immunology and Infection, V38, P417
Zecavati N, 2009, CURR NEUROL NEUROSCI, V9, P129, DOI 10.1007/s11910-009-0021-x
NR 28
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
EI 1708-8283
J9 J CHILD NEUROL
JI J. Child Neurol.
PD MAY
PY 2014
VL 29
IS 5
BP 708
EP 714
DI 10.1177/0883073813508314
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA AG0FJ
UT WOS:000335090400022
PM 24782421
ER
PT J
AU Puts, NAJ
Wodka, EL
Tommerdahl, M
Mostofsky, SH
Edden, RAE
AF Puts, Nicolaas A. J.
Wodka, Ericka L.
Tommerdahl, Mark
Mostofsky, Stewart H.
Edden, Richard A. E.
TI Impaired tactile processing in children with autism spectrum disorder
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
DE autism; inhibition; tactile; somatosensory; psychophysics
ID GABA CONCENTRATION; CANDIDATE GENE; SENSITIVITY; ADAPTATION; DISRUPTION;
GABRB3; ADULTS; DISCRIMINATION; INDIVIDUALS; PERCEPTION
AB Impaired responses to tactile stimulation are a commonly reported symptom among children with autism spectrum disorder (ASD). Furthermore, impairments in filtering or habituation to tactile input have been described in ASD. This study measured different aspects of tactile processing to investigate atypical touch sensitivity in children with ASD, methodology that has not been previously used in this population. Sixty-seven typically developing children (TDC) and 32 children with ASD (ages 8-12) completed vibrotactile tasks assessing: reaction time (RT); static and dynamic detection threshold (DT); amplitude discrimination with and without single-site adaptation; frequency discrimination; and temporal order judgment (TOJ) with and without concurrent stimulation. Children with ASD showed raised static detection thresholds and an absence of the effect of a dynamically increasing subthreshold stimulus on static detection threshold. Children with ASD also showed poorer amplitude discrimination than TDC, as well as decreased adaptation. There were no significant differences in frequency discrimination or TOJ performance between the groups. Differences in the effect of dynamic stimulation on detection threshold suggest impaired feed-forward inhibition in autism, which may be linked to poor sensory filtering. Increased baseline amplitude discrimination thresholds in ASD suggest that lateral inhibitory connections are weaker in ASD, and an absence of the effect of adaptation suggests impaired modulation of lateral inhibitory connections in ASD, which may relate to aberrant habituation. These results suggest a functional deficit in the somatosensory inhibitory system in autism. Understanding the specific mechanisms underlying sensory symptoms in autism may allow for more specific therapeutic or drug targeting in the near future.
C1 [Puts, Nicolaas A. J.; Edden, Richard A. E.] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA.
[Puts, Nicolaas A. J.; Edden, Richard A. E.] Kennedy Krieger Inst, FM Kirby Ctr Funct Brain Imaging, Baltimore, MD USA.
[Wodka, Ericka L.; Mostofsky, Stewart H.] Kennedy Krieger Inst, Lab Neurocognit & Imaging Res, Baltimore, MD USA.
[Wodka, Ericka L.] Kennedy Krieger Inst, Ctr Autism & Related Disorders, Baltimore, MD USA.
[Mostofsky, Stewart H.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
[Wodka, Ericka L.; Mostofsky, Stewart H.] Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA.
[Tommerdahl, Mark] Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC USA.
RP Puts, NAJ (reprint author), Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21287 USA.
EM nputs1@jhmi.edu
FU Autism Speaks Translational Postdoctoral Fellowship; Organization for
Autism Research; National Institutes of Health [P41-EB-015909,
R21-MH-098228, 2-R01-NS-048527-08, 2-R01-MH-078160-06A1]; Johns Hopkins
University School of Medicine Institute for Clinical and Translational
Research National Institutes of Health/ National Center for Research
Resources Clinical and Translational Science Award Program
[UL1-RR-025005]
FX N. A. Puts is funded by an Autism Speaks Translational Postdoctoral
Fellowship. E. L. Wodka is supported by the Organization for Autism
Research. This work was further supported by National Institutes of
Health Grants P41-EB-015909, R21-MH-098228, 2-R01-NS-048527-08, and
2-R01-MH-078160-06A1 and Johns Hopkins University School of Medicine
Institute for Clinical and Translational Research National Institutes of
Health/ National Center for Research Resources Clinical and
Translational Science Award Program UL1-RR-025005. None of the funding
bodies had influence on the acquisition or analysis of the data nor on
the writing and submission of this article.
CR Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
Blankenburg F, 2003, SCIENCE, V299, P1864, DOI 10.1126/science.1080806
Casanova MF, 2002, NEUROLOGY, V58, P428
Casanova MF, 2004, ANN NEUROL, V56, P54
Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
DeLorey TM, 2011, BEHAV BRAIN RES, V216, P36, DOI 10.1016/j.bbr.2010.06.032
Delorey TM, 2005, INT REV NEUROBIOL, V71, P359, DOI 10.1016/S0074-7742(05)71015-1
Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026
Favorov OV, 2011, J NEUROPHYSIOL, V105, P1342, DOI 10.1152/jn.00708.2010
Gaetz W, 2014, NEUROIMAGE, V86, P1, DOI 10.1016/j.neuroimage.2013.05.068
Guclu B, 2007, SOMATOSENS MOT RES, V24, P21, DOI 10.1080/08990220601179418
Holden JK, 2012, J NEUROSCI METH, V204, P215, DOI 10.1016/j.jneumeth.2011.11.007
Kohn A, 2007, J NEUROPHYSIOL, V97, P3155, DOI 10.1152/jn.00086.2007
Kohn A, 2002, BEHAV BRAIN RES, V135, P119, DOI 10.1016/S0166-4328(02)00139-0
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
McLaughlin DF, 2005, CEREB CORTEX, V15, P1791, DOI 10.1093/cercor/bhi056
Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
O'Riordan M, 2006, J AUTISM DEV DISORD, V36, P665, DOI 10.1007/s10803-006-0106-1
Puts NAJ, 2013, J NEUROSCI METH, V218, P39, DOI 10.1016/j.jneumeth.2013.04.012
Puts NAJ, 2011, J NEUROSCI, V31, P16556, DOI 10.1523/JNEUROSCI.4489-11.2011
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
Rojas DC, 2014, NEUROIMAGE, V86, P28, DOI 10.1016/j.neuroimage.2013.01.045
Rojas DC, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-11
Tannan V, 2007, BRAIN RES, V1186, P164, DOI 10.1016/j.brainres.2007.10.024
Tannan V, 2008, AUTISM RES, V1, P223, DOI 10.1002/aur.34
Tavassoli T, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-6
Tommerdahl M, 2010, NEUROSCI BIOBEHAV R, V34, P160, DOI 10.1016/j.neubiorev.2009.08.009
Tommerdahl M, 2007, BRAIN RES, V1154, P116, DOI 10.1016/j.brainres.2007.04.032
Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-19
Wechsler D., 2003, WECHSLER INTELLIGENC
Whitsel BL, 2003, SOMATOSENS MOT RES, V20, P45, DOI 10.1080/0899022031000083834
Whitsel BL, 1989, SENSORY PROCESSING M, P84
Zhang Z, 2011, FRONT AGING NEUROSCI, V3, DOI 10.3389/fnagi.2011.00018
NR 36
TC 6
Z9 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
EI 1522-1598
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD MAY
PY 2014
VL 111
IS 9
BP 1803
EP 1811
DI 10.1152/jn.00890.2013
PG 9
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA AG9ZR
UT WOS:000335779300009
PM 24523518
ER
PT J
AU Kim, YS
Fombonne, E
Koh, YJ
Kim, SJ
Cheon, KA
Leventhal, BL
AF Kim, Young Shin
Fombonne, Eric
Koh, Yun-Joo
Kim, Soo-Jeong
Cheon, Keun-Ah
Leventhal, Bennett L.
TI A Comparison of DSM-IV Pervasive Developmental Disorder and DSM-5 Autism
Spectrum Disorder Prevalence in an Epidemiologic Sample
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE ASD; SCD; DSM-IV; DSM-5; prevalence
ID CRITERIA; CHILDREN
AB Objective: Changes in autism diagnostic criteria found in DSM-5 may affect autism spectrum disorder (ASD) prevalence, research findings, diagnostic processes, and eligibility for clinical and other services. Using our published, total-population Korean prevalence data, we compute DSM-5 ASD and social communication disorder (SCD) prevalence and compare them with DSM-IV pervasive developmental disorder (PDD) prevalence estimates. We also describe individuals previously diagnosed with DSM-IV PDD when diagnoses change with DSM-5 criteria. Method: The target population was all children from 7 to 12 years of age in a South Korean community (N = 55,266), those in regular and special education schools, and a disability registry. We used the Autism Spectrum Screening Questionnaire for systematic, multi-informant screening. Parents of screen-positive children were offered comprehensive assessments using standardized diagnostic procedures, including the Autism Diagnostic Interview Revised and Autism Diagnostic Observation Schedule. Best-estimate clinical diagnoses were made using DSM-IV PDD and DSM-5 ASD and SCD criteria. Results: DSM-5 ASD estimated prevalence was 2.20% (95% confidence interval = 1.77-3.64). Combined DSM-5 ASD and SCD prevalence was virtually the same as DSM-IV PDD prevalence (2.64%). Most children with autistic disorder (99%), Asperger disorder (92%), and PDD-NOS (63%) met DSM-5 ASD criteria, whereas 1%, 8%, and 32%, respectively, met SCD criteria. All remaining children (2%) had other psychopathology, principally attention-deficit/hyperactivity disorder and anxiety disorder. Conclusion:. Our findings suggest that most individuals with a prior DSM-IV PDD meet DSM-5 diagnostic criteria for ASD and SCD. PDD, ASD or SCD; extant diagnostic criteria identify a large, clinically meaningful group of individuals and families who require evidence-based services.
C1 [Kim, Young Shin] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
[Kim, Young Shin; Leventhal, Bennett L.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
[Kim, Young Shin; Cheon, Keun-Ah; Leventhal, Bennett L.] Yonsei Univ, Seoul 120749, South Korea.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Koh, Yun-Joo] Korea Inst Childrens Social Dev Rudolph, Seoul, South Korea.
[Kim, Soo-Jeong] Univ Washington, Seattle, WA 98195 USA.
[Leventhal, Bennett L.] Univ Illinois, Chicago, IL USA.
RP Leventhal, BL (reprint author), Nathan S Kline Inst Psychiat Res, 140 Old Orangeburg Rd,Bldg 35, Orangeburg, NY 10962 USA.
FU Autism Speaks Pilot Research Grant; Brain Research Foundation; Simons
Foundation [137032 M134793]; National Institute for Mental Health (NIMH)
[5K01MH079317-02, K23MH082883]; National Institute of Environmental
Health Sciences (NIEHS) [R01 ES021462-01]; Korean Health Technology
Research and Development Project, Ministry of Health and Welfare
[HI12C0021, HI12C0245-A120029]; Jean Young and Walden W. Shaw
Foundation; Daniel X. and Mary Freedman Foundation; Dukyoung Foundation;
[7996]
FX This research was funded by an Autism Speaks Pilot Research Grant, and a
Supplement Grant (7996), a Brain Research Foundation Research Grant, a
Simons Foundation Autism Research Initiative Pilot Grant (137032
M134793), the National Institute for Mental Health (NIMH) Career Awards
(5K01MH079317-02 [Y.S.K.] and K23MH082883 [S.J.K.]), the National
Institute of Environmental Health Sciences (NIEHS) R01 Award (R01
ES021462-01), and the Korean Health Technology Research and Development
Project, Ministry of Health and Welfare (HI 12C0021;
HI12C0245-A120029).Additional funding was provided by the Jean Young and
Walden W. Shaw Foundation, the Daniel X. and Mary Freedman Foundation,
and the Dukyoung Foundation.
CR American Psychiatric Association, 2013, DSM5 AM PSYCH ASS
American Psychiatric Association, 2013, A05 SOC COMM
[Anonymous], 2012, NY TIMES
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508
Fombonne E, 2009, PEDIATR RES, V65, P591
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Gibbs V, 2012, J AUTISM DEV DISORD, V42, P1750, DOI 10.1007/s10803-012-1560-6
Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
Kelsey J. L., 1996, METHODS OBSERVATIONA
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
Taheri A, 2012, J AUTISM DEV DISORD, V42, P1810, DOI 10.1007/s10803-012-1599-4
NR 14
TC 2
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD MAY
PY 2014
VL 53
IS 5
BP 500
EP 508
DI 10.1016/j.jaac.2013.12.021
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AG0HJ
UT WOS:000335096200004
PM 24745950
ER
PT J
AU Strickland, AD
AF Strickland, Alan D.
TI Prevention of cerebral palsy, autism spectrum disorder, and attention
deficit - Hyperactivity disorder
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FETAL HYPOXIA-ISCHEMIA; FATTY-ACID COMPOSITION; WHITE-MATTER;
DEFICIT/HYPERACTIVITY DISORDER; DOCOSAHEXAENOIC ACID; NEONATAL-RATS;
BRAIN; INFLAMMATION; MICROGLIA; DAMAGE
AB This hypothesis states that cerebral palsy (CP), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) are all caused by an exaggerated central nervous system inflammatory response to a prenatal insult. This prenatal insult may be one or more episodes of ischemia-reperfusion, an infectious disease of the mother or the fetus, or other causes of maternal inflammation such as allergy or autoimmune disease. The resultant fetal inflammatory hyper-response injures susceptible neurons in the developing white matter of the brain in specific areas at specific gestational ages. The exaggerated neuroinflammatory response is theorized to occur between about 19 and 34 post-conception weeks for CP, about 32 and 40 weeks for ADHD, and about 36 and 48 weeks (i.e. 2 months after delivery) for ASD. The exaggerated inflammatory response is hypothesized to occur because present diets limit intake of effective antioxidants and omega-3 polyunsaturated fatty acids while increasing intake of omega-6 polyunsaturated fatty acids. Oxidation products of the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) limit neuroinflammation while oxidation products of the omega-6 fatty acid arachidonic acid exacerbate inflammation. Preventative treatment should begin in all pregnant women during the first trimester and should include both DHA and an effective antioxidant for prevention of neuroinflammation. The suggested antioxidant would be N-acetylcysteine, though melatonin could be chosen instead. Combined DHA and NAC therapy is theorized to decrease the incidence of the three disorders by more than 75%. (C) 2014 Elsevier Ltd. All rights reserved.
RP Strickland, AD (reprint author), 101 Waterlily, Lake Jackson, TX 77566 USA.
EM astricklandcons@gmail.com
CR Adams LB, 2011, BMC GASTROENTEROL, V11, P22
Angelidou A, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-89
[Anonymous], 2013, HUMAN ANATOMY GRAYS
Bas O, 2007, NEUROCHEM INT, V50, P548, DOI 10.1016/j.neuint.2006.11.005
Bax M, 2006, JAMA-J AM MED ASSOC, V296, P1602
Beloosesky R, 2013, AM J OBSTET GYNECOL, V208, P213
Beloosesky R, 2013, AM J OBSTET GYNECOL, V208, pe1
Bilenberg N, 2011, J NEUROIMMUNOL, V236, P72, DOI 10.1016/j.jneuroim.2011.04.012
Billiards SS, 2006, J COMP NEUROL, V497, P199, DOI 10.1002/cne.20991
Blomgren K, 2006, FREE RADICAL BIO MED, V40, P388, DOI 10.1016/j.freeradbiomed.2005.08.040
BOGOUSSLAVSKY J, 1988, STROKE, V19, P1083
Burd I, 2010, J NEUROSCI RES, V88, P1872, DOI 10.1002/jnr.22368
Capute AJ, 2001, DEV DISABILITIES INF, V2
CASTELLANOS FX, 1994, AM J PSYCHIAT, V151, P1791
Castellanos FX, 2003, AM J PSYCHIAT, V160, P1693, DOI 10.1176/appi.ajp.160.9.1693
Cherkasova MV, 2009, CAN J PSYCHIAT, V54, P651
Chhor V, 2012, ARCH PEDIATRIE, V19, P946, DOI 10.1016/j.arcped.2012.06.013
Cunningham CL, 2013, J NEUROSCI, V33, P4216, DOI 10.1523/JNEUROSCI.3441-12.2013
Das UN, 2013, NUTRITION, V29, P1175, DOI 10.1016/j.nut.2013.01.012
Derrick M, 2004, J NEUROSCI, V24, P24, DOI 10.1523/JNEUROSCI.2816-03.2004
Derrick M, 2007, STROKE, V38, P731, DOI 10.1161/01.STR.0000251445.94697.64
Derrick M, 2009, INT J DEV NEUROSCI, V27, P549, DOI 10.1016/j.ijdevneu.2009.06.008
Dias MS, 2001, PEDIAT NEUROSURGERY
Elovitz MA, 2011, INT J DEV NEUROSCI, V29, P663, DOI 10.1016/j.ijdevneu.2011.02.011
Emond V, 2009, ENCEPHALE, V35, P107, DOI 10.1016/j.encep.2008.01.005
Faraone Stephen V, 2003, World Psychiatry, V2, P104
Folkerth RD, 2006, PEDIATR DEVEL PATHOL, V9, P3, DOI 10.2350/06-01-0024.1
Folkerth RD, 2005, J CHILD NEUROL, V20, P940, DOI 10.1177/08830738050200120301
Gerstner B, 2007, ANN NEUROL, V61, P562, DOI 10.1002/ana.21118
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Hamada F, 2010, NEONATOLOGY, V98, P33, DOI 10.1159/000264205
Jacobsson B, 2004, BEST PRACT RES CL OB, V18, P426
Kim HY, 2007, J BIOL CHEM, V282, P18661, DOI 10.1074/jbc.R700015200
KIM HY, 1991, BIOCHEM BIOPH RES CO, V174, P729, DOI 10.1016/0006-291X(91)91478-U
Kirby RS, 2011, RES DEV DISABIL, V32, P462, DOI 10.1016/j.ridd.2010.12.042
Lante F, 2008, HIPPOCAMPUS, V18, P602, DOI 10.1002/hipo.20421
LI BY, 1994, J LIPID RES, V35, P1869
Lin JP, 2003, J NEUROL NEUROSUR PS, V74, DOI 10.1136/jnnp.74.suppl_1.i23
Mach Mojmír, 2009, Interdiscip Toxicol, V2, P28, DOI 10.2478/v10102-009-0005-3
MARINKOVIC SV, 1985, STROKE, V16, P1022
McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332
Morgan JT, 2012, BRAIN RES, V1456, P72, DOI 10.1016/j.brainres.2012.03.036
Mueller S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067329
NELSON KB, 1986, NEW ENGL J MED, V315, P81, DOI 10.1056/NEJM198607103150202
Nelson KB, 2003, NEW ENGL J MED, V349, P1765, DOI 10.1056/NEJMsb035364
Odding E, 2006, DISABIL REHABIL, V28, P183, DOI 10.1080/09638280500158422
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Raybaud C, 2010, NEUROSURG CLIN N AM, V21, P399, DOI 10.1016/j.nec.2010.03.011
Rezaie P, 2005, CEREB CORTEX, V15, P938, DOI 10.1093/cercor/bhh194
Rodriguez JI, 2012, NEURON GLIA BIOL, P1
Roumier A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002595
Roxane Laboratories Inc., 2007, AC PACK INS
Schmahmann JD, 2003, STROKE, V34, P2264, DOI 10.1161/01.STR.0000087786.38997.9E
Schneider M, 2006, EUR ARCH PSY CLIN N, V256, P32, DOI 10.1007/s00406-006-1005-3
Shen MD, 2013, BRAIN, V136, P2825, DOI 10.1093/brain/awt166
Silk TJ, 2009, HUM BRAIN MAPP, V30, P2757, DOI 10.1002/hbm.20703
Silva D, 2014, PEDIATRICS, V133, P1
Simopoulos AP, 2001, NUTR HLTH, P3
Stolp HB, 2009, NEUROSCI LETT, V451, P232, DOI 10.1016/j.neulet.2009.01.021
Stolp HB, 2009, NEUROPATH APPL NEURO, V35, P132, DOI 10.1111/j.1365-2990.2008.01005.x
SVENNERH.L, 1973, BRAIN RES, V50, P341, DOI 10.1016/0006-8993(73)90735-X
SVENNERH.L, 1968, J LIPID RES, V9, P570
US Department of Agriculture data files, DIET INT VIT E LIN A
Verney C, 2010, J ANAT, V217, P436, DOI 10.1111/j.1469-7580.2010.01245.x
Watanabe K, 2012, J MATERN-FETAL NEO M, V25, P1254, DOI 10.3109/14767058.2011.636094
Watchko JF, 2013, NEW ENGL J MED, V369, P2021, DOI 10.1056/NEJMra1308124
Wojcicki JM, 2011, J MATERN-FETAL NEO M, V24, P680, DOI 10.3109/14767058.2010.521873
Xu G, 2011, J NEUROPATH EXP NEUR, V70, P841, DOI 10.1097/NEN.0b013e31822f471c
Yao LL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078439
Yavin E, 2001, J MOL NEUROSCI, V16, P229, DOI 10.1385/JMN:16:2-3:229
You X, 2013, FRONT HUM NEUROSCI, V7, P1
NR 71
TC 3
Z9 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2014
VL 82
IS 5
BP 522
EP 528
DI 10.1016/j.mehy.2014.02.003
PG 7
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AG0KT
UT WOS:000335105100004
PM 24581674
ER
PT J
AU Wen, W
Wen, SW
AF Wen, Wendy
Wen, Shi Wu
TI Expanding upon the 'extreme male brain' theory of autism as a common
link between other major risk factors: A hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
ID SEX-DIFFERENCES; EMPATHY QUOTIENT; AGGRESSION; MECHANISMS
AB On average, males have a stronger preference for physical systems and machines over interpersonal interactions; they have lower average levels of cognitive empathy or social cognition than females; and they have higher rates of 'extreme' intelligence when it comes to abstract concepts such as those found in mathematics and sciences. All three traits are also commonly associated with individuals with an autism spectrum disorder or ASD; clearly, it is not coincidental that incidence rates of autism are reportedly four times higher in males than in females.
The common link between the majority of risk factors assessed in this review (including technological advancements, advanced parental age, socioeconomic status, and genetic predispositions towards ASDs in families of scientists and engineers) can be traced to a specific hormone, testosterone. It was established that traits which are typically associated with males are also typically associated with ASDs as well as individuals with antisocial personality disorder, or APD. The key distinction between individuals who are considered to be 'autistic' as opposed to those who are considered 'sociopathic' lies in the difference between their empathy deficits: whereas those who are 'autistic' are said to lack cognitive empathy (the ability to identify and understand the thoughts and feelings of others and to respond to these with appropriate emotions), those who are 'sociopathic' are said to lack emotional empathy (which is responsible for inhibiting acts of physical aggression or violence). This would explain why autistic individuals can have elevated testosterone levels without becoming physically aggressive. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Wen, Wendy] Univ Ottawa, Dept Math & Stat, Fac Sci, Ottawa, ON K1H 8L6, Canada.
[Wen, Shi Wu] Univ Ottawa, Dept Obstet & Gynecol, OMNI Res Grp, Ottawa, ON K1H 8L6, Canada.
[Wen, Shi Wu] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
[Wen, Shi Wu] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON K1H 8L6, Canada.
RP Wen, SW (reprint author), Univ Ottawa, Dept Obstet & Gynecol, OMNI Res Grp, Fac Med, 501 Smyth Rd,Box 241, Ottawa, ON K1H 8L6, Canada.
EM swwen@ohri.ca
CR Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514
American Psychological Association Task Force on Socioeconomic Status, 2007, REP APA TASK FORC SO
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Durkin Maureen S, 2010, PLOS ONE, V5
Durkin Maureen S, 2008, AM J EPIDEMIOL, V168
Hughes JR, 2009, EPILEPSY BEHAV, V16, P569, DOI 10.1016/j.yebeh.2009.09.023
John Duffy, 2011, J LIT CULTUR DISABIL, V5, P201
Knickmeyer RC, 2006, J CHILD NEUROL, V21, P825, DOI 10.2310/7010.2006.00213
Krieger LM, 2010, AUTISM CLUSTER FOUND
Milian Mark J, 2013, NEUROPHARMACOLOGY, V68, P2
Richler J, 2003, SYSTEMIZING QUOTIENT
Rutter M, 2003, J CHILD PSYCHOL PSYC, V44, P1092, DOI 10.1111/1469-7610.00194
Sato Tamotsu, 1991, Acta Paediatrica Japonica, V33, P639
Simon Baron-Cohen, 1998, SAGE, V2, P296
Simon Baron-Cohen, 2011, ZERO DEGREES EMPATHY
Simon Baron-Cohen, 2003, ESSENTIAL DIFFERENCE
Soma KK, 2008, FRONT NEUROENDOCRIN, V29, P476, DOI 10.1016/j.yfrne.2007.12.003
Soma KK, 2000, J COMP PHYSIOL A, V186, P759, DOI 10.1007/s003590000129
University of Florida, 2006, STUD EXPL WHY BOYS F
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
Zuloaga DG, 2008, HORM BEHAV, V53, P613, DOI 10.1016/j.yhbeh.2008.01.013
NR 21
TC 0
Z9 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2014
VL 82
IS 5
BP 615
EP 618
DI 10.1016/j.mehy.2014.02.020
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AG0KT
UT WOS:000335105100019
PM 24629356
ER
PT J
AU Lionello-DeNolf, KM
Farber, R
Jones, BM
Dube, WV
AF Lionello-DeNolf, Karen M.
Farber, Rachel
Jones, B. Max
Dube, William V.
TI Thematic matching as remedial teaching for symbolic matching for
individuals with autism spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Matching-to-sample; Symbolic behavior; Thematic matching; Children with
ASD
ID COMMUNICATION-SYSTEM PECS; MENTALLY-RETARDED ADULTS; CONDITIONAL
DISCRIMINATION; ERROR-CORRECTION; CHILDREN; DISABILITIES; EQUIVALENCE;
ACQUISITION; SKILLS
AB Matching-to-sample (MTS) is often used to teach symbolic relationships between spoken or printed words and their referents to children with intellectual and developmental disabilities. However, many children have difficulty learning symbolic matching, even though they may demonstrate generalized identity matching. The current study investigated whether training on symbolic MTS tasks in which the stimuli are physically dissimilar but members of familiar categories (i.e., thematic matching) can remediate an individual's difficulty learning symbolic MTS tasks involving non-representative stimuli. Three adolescent males diagnosed with autism spectrum disorder were first trained on symbolic MTS tasks with unfamiliar, non-representative form stimuli. Thematic matching was introduced after the participants failed to learn 0, 2 or 4 symbolic MTS tasks and before additional symbolic MTS tasks were introduced. After exposure to thematic matching, accuracy on symbolic MTS tasks with novel stimuli increased to above chance for all participants. For two participants, high accuracy (>90%) was achieved on a majority of these sessions. Thus, thematic matching may be an effective intervention for students with limited verbal repertoires and who have difficulty learning symbolic MTS tasks. Possible explanations for the facilitative effect of thematic matching are considered and warrant further investigation. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lionello-DeNolf, Karen M.; Farber, Rachel; Dube, William V.] Univ Massachusetts, Sch Med, Shriver Ctr, Worcester, MA 01655 USA.
[Jones, B. Max] Curtin Univ, Sch Psychol & Speech Pathol, Perth, WA 6845, Australia.
RP Lionello-DeNolf, KM (reprint author), Univ Massachusetts, Sch Med, Shriver Ctr, Lake Ave North S3-301, Worcester, MA 01655 USA.
EM Karen.Lionello-DeNolf@umassmed.edu; Rachel.Farber@umassmed.edu;
Brent.jones@curtin.edu.au; William.Dube@umassmed.edu
CR BARNES D, 1994, PSYCHOL REC, V44, P91
Boesch MC, 2013, RES AUTISM SPECT DIS, V7, P480, DOI 10.1016/j.rasd.2012.12.002
Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
CARTER DE, 1975, SCIENCE, V187, P662, DOI 10.1126/science.1114318
Clark KM, 2004, J APPL BEHAV ANAL, V37, P503, DOI 10.1901/jaba.2004.37-503
Cummings AR, 2012, RES AUTISM SPECT DIS, V6, P32, DOI 10.1016/j.rasd.2011.08.006
DUBE WV, 1989, J EXP ANAL BEHAV, V51, P65, DOI 10.1901/jeab.1989.51-65
Dunn L. M., 2007, PEABODY PICTURE VOCA
EIKESETH S, 1992, J EXP ANAL BEHAV, V58, P123, DOI 10.1901/jeab.1992.58-123
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Hammond JL, 2012, RES DEV DISABIL, V33, P1, DOI 10.1016/j.ridd.2011.08.021
HARLOW HF, 1949, PSYCHOL REV, V56, P51, DOI 10.1037/h0062474
Hayes S. C., 1994, BEHAV ANAL LANGUAGE, P9
Healy O, 2000, J EXP ANAL BEHAV, V74, P207, DOI 10.1901/jeab.2000.74-207
Klinger L., 2003, CHILD PSYCHOPATHOLOG, P409
Lancioni GE, 2007, RES DEV DISABIL, V28, P468, DOI 10.1016/j.ridd.2006.06.003
Mansfield R., 2011, U.S. Patent, Patent No. [7,974,569B2, 7974569]
MATLAB, 2010, MATLAB COMPUTER SOFT
May M. E., 2004, J BEHAV ED, V13, P267, DOI 10.1023/B:JOBE.0000044735.51022.5d
Mayer-Johnson, 2008, PICTURE COMMUNICATIO
McIlvane WJ, 2003, BEHAV ANALYST, V26, P195
McIlvane WJ, 2002, J EXP ANAL BEHAV, V77, P189, DOI 10.1901/jeab.2002.77-189
Perez-Gonzalez LA, 2002, AM J MENT RETARD, V107, P293, DOI 10.1352/0895-8017(2002)107<0293:MPTTCD>2.0.CO;2
Pilgrim C, 2000, J EXP ANAL BEHAV, V73, P177, DOI 10.1901/jeab.2000.73-177
RODGERS TA, 1991, J APPL BEHAV ANAL, V24, P775, DOI 10.1901/jaba.1991.24-775
Rosenberger P.B., 1972, LANGUAGE MENTALLY RE, P211
SAUNDERS KJ, 1993, J EXP ANAL BEHAV, V60, P571, DOI 10.1901/jeab.1993.60-571
SAUNDERS KJ, 1989, J EXP ANAL BEHAV, V52, P1, DOI 10.1901/jeab.1989.52-1
SAUNDERS KJ, 1990, J EXP ANAL BEHAV, V54, P239, DOI 10.1901/jeab.1990.54-239
SIDMAN M, 1973, AM J MENT DEF, V77, P515
SMEETS PM, 1994, Q J EXP PSYCHOL-B, V47, P241
Smith T, 2006, BEHAV INTERVENT, V21, P245, DOI 10.1002/bin.223
ZYGMONT DM, 1992, J EXP ANAL BEHAV, V57, P109, DOI 10.1901/jeab.1992.57-109
NR 33
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD MAY
PY 2014
VL 8
IS 5
BP 455
EP 462
DI 10.1016/j.rasd.2014.01.004
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AG0LO
UT WOS:000335107200001
ER
EF