FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Richdale, AL
   Baker, E
   Short, M
   Gradisar, M
AF Richdale, Amanda L.
   Baker, Emma
   Short, Michelle
   Gradisar, Michael
TI The role of insomnia, pre-sleep arousal and psychopathology symptoms in
   daytime impairment in adolescents with high-functioning autism spectrum
   disorder
SO SLEEP MEDICINE
LA English
DT Article
DE Autism; Insomnia; Daytime functioning; Anxiety; Arousal; Depression;
   Adolescence
ID ANXIETY DISORDERS; CHILDREN; DISTURBANCES; DEPRESSION; REDUCTION; PARENT
AB Objectives: Sleep disturbance and psychopathology are common during adolescence and are highly prevalent in individuals diagnosed with autism spectrum disorder (ASD). The aim of this study was to investigate relationships between sleep disturbance, psychopathology symptoms, and daytime functioning in adolescents with high-functioning autism spectrum disorder (HFASD) compared to typically developing (TD) adolescents.
   Methods: Twenty-seven adolescents with HFASD and 27 age- and sex-matched TD adolescents completed questionnaires related to sleep, psychopathology and daytime functioning. Participants also completed a 7-day sleep/wake diary. A subsample of HFASD adolescents (55%) and all the TD adolescents wore an actigraphy monitor concurrently with the sleep diary.
   Results: Adolescents with HFASD had significantly higher scores for depressed mood, anxiety and pre-sleep arousal compared with TD adolescents and poorer daytime functioning. There were more significant correlations between sleep variables and psychopathology variables, and sleep variables and daytime functioning, in the HFASD group than in the TD group. Standard regression found that sleep variables significantly accounted for 57% of the variance in daytime functioning symptoms of insufficient sleep in the HFASD group, while psychopathology variables accounted for 63% of the variance in daytime functioning.
   Conclusions: Both sleep disturbance and psychopathology are more prevalent in adolescents with HFASD and are major contributors to poor daytime functioning in these individuals. (C) 2014 Published by Elsevier B.V.
C1 [Richdale, Amanda L.; Baker, Emma] La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Melbourne, Vic, Australia.
   [Short, Michelle] Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia.
   [Gradisar, Michael] Flinders Univ S Australia, Sch Psychol, Adelaide, SA 5001, Australia.
RP Richdale, AL (reprint author), La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Kingsbury Dr, Bundoora, Vic 3086, Australia.
EM a.richdale@latrobe.edu.au
CR Allik H, 2006, BMC PSYCHIATRY, V6, P6
   *AM AC CHILD AD PS, 2007, J AM ACAD CHILD ADOL, V46, P1503
   American Academy of Sleep Medicine, 2005, INT CLASS SLEEP DIS, V2nd
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baker E, 2013, DEV NEUROREHABIL, V16, P155, DOI 10.3109/17518423.2013.765518
   Blakeley-Smith A, 2012, RES AUTISM SPECT DIS, V6, P707, DOI 10.1016/j.rasd.2011.07.020
   Bootzin R, 1994, SLEEP RES, V23, P188
   Breslau N, 1996, BIOL PSYCHIAT, V39, P411, DOI 10.1016/0006-3223(95)00188-3
   CARSKADON MA, 1993, J ADOLESCENT HEALTH, V14, P190, DOI 10.1016/1054-139X(93)90004-9
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Coakes SJ, 2009, SPSS 16 0 WINDOWS AN
   Dahl RE, 2007, SLEEP MED CLIN, V2, P501, DOI 10.1016/j.jsmc.2007.05.002
   Dewald JF, 2012, J SLEEP RES, V21, P584, DOI 10.1111/j.1365-2869.2012.00999.x
   Dewald JF, 2010, SLEEP MED REV, V14, P179, DOI 10.1016/j.smrv.2009.10.004
   Goldman SE, 2011, RES AUTISM SPECT DIS, V5, P1223, DOI 10.1016/j.rasd.2011.01.010
   Gregory AM, 2008, SLEEP, V31, P1745
   Gregory AM, 2012, SLEEP MED REV, V16, P129, DOI 10.1016/j.smrv.2011.03.007
   Harvey AG, 2005, J COGNITIVE PSYCHOTH, V19, P41, DOI DOI 10.1891/JC0P.19.1.41.66332
   Harvey AG, 2002, BEHAV RES THER, V40, P869, DOI 10.1016/S0005-7967(01)00061-4
   Leahy E, 2012, CLIN PSYCHOL-UK, V16, P44, DOI 10.1111/j.1742-9552.2012.00039.x
   LICHSTEIN KL, 1980, J ABNORM PSYCHOL, V89, P105, DOI 10.1037//0021-843X.89.1.105
   Lovato N, SLEEP MED R IN PRESS
   LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
   Mayes SD, 2009, RES AUTISM SPECT DIS, V3, P931, DOI 10.1016/j.rasd.2009.04.002
   Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P474, DOI 10.1016/j.rasd.2010.06.012
   Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
   Keehn RHM, 2013, J AUTISM DEV DISORD, V43, P57, DOI 10.1007/s10803-012-1541-9
   Meijer AM, 2008, J SLEEP RES, V17, P395, DOI 10.1111/j.1365-2869.2008.00677.x
   Moon EC, 2011, J PEDIATR PSYCHOL, V36, P47, DOI 10.1093/jpepsy/jsq057
   Norman G, 2010, ADV HEALTH SCI EDUC, V15, P625, DOI 10.1007/s10459-010-9222-y
   Ozsivadjian A, 2012, AUTISM, V16, P107, DOI 10.1177/1362361311431703
   Paavonen EJ, 2008, J AUTISM DEV DISORD, V38, P41, DOI 10.1007/s10803-007-0360-x
   Pallant J, 2011, SPSS SURVIVAL MANUAL, V4th
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Richdale AL, 2013, DEV NEURORE IN PRESS
   Rutter M., 2003, SOCIAL COMMUNICATION
   SADEH A, 1994, SLEEP, V17, P201
   Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015
   Turner KS, 2013, TOP EARLY CHILD SPEC, V33, P144, DOI 10.1177/0271121412446204
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   Wolfson AR, 2003, SLEEP, V26, P213
NR 41
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD SEP
PY 2014
VL 15
IS 9
BP 1082
EP 1088
DI 10.1016/j.sleep.2014.05.005
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA AO6TA
UT WOS:000341483200013
PM 24974199
ER

PT J
AU Angell, AM
   Solomon, O
AF Angell, Amber M.
   Solomon, Olga
TI The social life of health records: Understanding families' experiences
   of autism
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE USA; African American; Autism; Family perspectives; Health record;
   Health disparities; Healthcare disparities; Meaningful use
ID SPECTRUM DISORDERS; DIAGNOSIS; CHILDREN; CARE; CALIFORNIA; CAPITATION;
   AGE
AB Outside of the epidemiological surveillance studies of autism prevalence, health records of children diagnosed with autism have not been sufficiently examined, yet they provide an important lens for showing how autism diagnosis, services and interventions are negotiated, coordinated and choreographed by families and practitioners across multiple settings. This article provides a multifaceted understanding of these processes from an ethnographic and discourse analytic perspective that reveals structural and interactional phenomena contributing to disparities in autism diagnosis and services. We consider health records as dualistic, material-discursive artifacts that are socio-interactionally co-constructed and variably interpreted, contested and utilized across home, school and clinic contexts. We chronicle several families' experiences of their children's autism diagnoses and interventions and describe ways in which health records are socially constructed, curated and placed in the middle of clinical encounters. We show how the parents in our study draw upon health records' material-discursive properties to display epistemic authority, expertise and knowledge in interactions with healthcare and school professionals involved in authorizing and planning their children's care. We describe how the parents experience the health records' clinical portrayals of their children and themselves, and how the parents' portrayals of their children are tacitly ratified or negated in the health records. The data include health record reviews, narrative interviews with parents and practitioners, and clinical observations. These data were collected between October 2009 and August 2012 as part of a larger study on disparities in autism diagnosis, interventions and services experienced by African American children with autism and their families living in Los Angeles County, California. Our analysis reveals the central role of health records in maintaining continuity of an autism diagnosis, interventions and services. This article contributes to enhanced professional awareness, parent-professional partnerships, and equity in the provision of healthcare and human services related to autism. (C) 2014 The Authors. Published by Elsevier Ltd.
C1 [Angell, Amber M.; Solomon, Olga] Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
RP Angell, AM (reprint author), Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
EM aangell@usc.edu; olga.solomon@usc.edu
FU grant Autism in Urban Context: Linking Heterogeneity with Health and
   Service Disparities (NIH/NIMH) [R01 MH089474]; Division of Occupational
   Science and Occupational Therapy at the USC Herman Ostrow School of
   Dentistry
FX We are deeply grateful to the children and their families who
   participated in this study. This study was supported by a grant Autism
   in Urban Context: Linking Heterogeneity with Health and Service
   Disparities (NIH/NIMH, R01 MH089474, 2009-2012, O. Solomon, P.I.). The
   content of this article is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institute of Mental Health or the National Institutes of Health. We
   thank the members of the Autism in Urban Context research team: Mary
   Lawlor, ScD, Sharon Cermak, EdD, Marie Poulsen, PhD, Thomas Valente,
   PhD, Marian Williams, PhD, and Larry Yin, MD; and post-doctoral
   researchers Kimberly Wilkinson, PhD and Tessa Milman, OTD. We also
   gratefully acknowledge the support of the Division of Occupational
   Science and Occupational Therapy at the USC Herman Ostrow School of
   Dentistry.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bakhtin M. M., 1986, SPEECH GENRES OTHER
   Berg M., 2004, BODY SOC, V10, P13, DOI DOI 10.1177/135703
   Berg M., 2004, HLTH INF MAN INT INF
   Centers for Disease Control and Prevention, 2011, MORBIDITY MORTAL W S, V60
   Centers for Disease Control and Prevention, 2014, PREV AUT SPECTR DIS
   Charon R, 2006, NARRATIVE MED HONORI
   Clarke K, 2003, METHOD INFORM MED, V42, P345
   de Wolfe J., 2013, THESIS COLUMBIA U
   Eyal G., 2010, BERKELEY J SOCIOL, V54, P3
   Feagin J, 2014, SOC SCI MED, V103, P7, DOI 10.1016/j.socscimed.2013.09.006
   Gallegos E., 2010, LOS ANGELES DLY J
   Gorman PN, 2003, METHOD INFORM MED, V42, P376
   GRAY DE, 1994, SOCIOL HEALTH ILL, V16, P275, DOI 10.1111/1467-9566.ep11348729
   Greatbatch D, 2001, Health Serv Manage Res, V14, P181, DOI 10.1258/0951484011912681
   Grice H. Paul, 1989, STUDIES WAY WORDS
   Heath C., 1996, DOCUMENTS PROFESSION
   Heritage J, 2012, RES LANG SOC INTERAC, V45, P1, DOI 10.1080/08351813.2012.646684
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   KERR EA, 1995, ANN INTERN MED, V123, P500
   Lawlor M.C., 2014, WILLARD SPACKMANS OC, P150
   Lilley R, 2011, AUST FEMINIST STUD, V26, P207, DOI 10.1080/08164649.2011.574600
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Magana S, 2012, INTELLECT DEV DISAB, V50, P287, DOI 10.1352/1934-9556-50.4.287
   Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Marvasti AB, 2002, J CONTEMP ETHNOGR, V31, P615, DOI 10.1177/089124102236544
   Matson JL, 2007, RES DEV DISABIL, V28, P207, DOI 10.1016/j.ridd.2005.07.006
   Mattingly C, 2008, ETHOS, V36, P136, DOI 10.1111/j.1548-1352.2008.00008.x
   Mattingly C, 2010, PARADOX OF HOPE: JOURNEYS THROUGH A CLINICAL BORDERLAND, P1
   ONCHIT, 2010, OFF NAT COORD HLTH I
   Plovnick RM, 2010, AM J PSYCHIAT, V167, P498, DOI 10.1176/appi.ajp.2009.09101473
   Robinson JC, 2001, HEALTH AFFAIR, V20, P81, DOI 10.1377/hlthaff.20.4.81
   ROBINSON JC, 1995, NEW ENGL J MED, V333, P1684, DOI 10.1056/NEJM199512213332506
   Rosenberg Charles E., 1987, CARE STRANGERS RISE
   Rudman DL, 2006, AGEING SOC, V26, P181, DOI 10.1017/S0144686X05004253
   Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
   Smedley BD, 2003, UNEQUAL TREATMENT CO
   Solomon O, 2010, ANNU REV ANTHROPOL, V39, P241, DOI 10.1146/annurev.anthro.012809.105012
   Solomon O, 2013, SOC SCI MED, V94, P106, DOI 10.1016/j.socscimed.2013.06.034
   Valentine K, 2010, SOC SCI MED, V71, P950, DOI 10.1016/j.socscimed.2010.06.010
   Valicenti-McDermott M, 2012, J PEDIATR-US, V161, P554, DOI 10.1016/j.jpeds.2012.05.012
   Williams ME, 2009, J AUTISM DEV DISORD, V39, P660, DOI 10.1007/s10803-008-0668-1
   Wodak R., 2004, QUALITATIVE RES PRAC, P197
   Zarembo A., 2011, LA TIMES        1213
NR 45
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD SEP
PY 2014
VL 117
BP 50
EP 57
DI 10.1016/j.socscimed.2014.07.020
PG 8
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA AO6SF
UT WOS:000341481100007
PM 25042544
ER

PT J
AU Fahnehjelm, KT
   Dahl, S
   Martin, L
   Ek, U
AF Fahnehjelm, Kristina Tear
   Dahl, Sara
   Martin, Lene
   Ek, Ulla
TI Optic nerve hypoplasia in children and adolescents; prevalence, ocular
   characteristics and behavioural problems
SO ACTA OPHTHALMOLOGICA
LA English
DT Article
DE behaviour disc; area optic nerve hypoplasia; prevalence
ID DOUBLING TECHNOLOGY PERIMETRY; VISUAL IMPAIRMENT; SWEDISH CHILDREN;
   RISK-FACTORS; SYSTEM ABNORMALITIES; YOUNG-CHILDREN; DYSPLASIA; SPECTRUM;
   RAREBIT; REAPPRAISAL
AB Purpose: To report prevalence, ocular characteristics and coexisting behavioural problems in children and adolescents with optic nerve hypoplasia (ONH), which is a common cause of visual impairment in children in western countries, often associated with neurological or endocrinological problems and where autism has been reported in severe cases with blindness.
   Methods: This is a population-based cross-sectional study of patients <20 years of age who had been diagnosed with NH and lived in the county of Stockholm in December 2009. Ophthalmological assessments including fundus photographs with optic disc analyses were made. A questionnaire was used to screen for behaviour and development.
   Results: The prevalence of ONH in all living children <18 years of age in Stockholm was 17.3/100 000 with a prevalence of visual impairment (<0.3) of 3.9/100 000. In total, 66 patients, median age 9.3 years (0.6-19.4), 36 with bilateral and 30 with unilateral ONH, were included in the current study; 53 were re-examined clinically, group A, and 13 agreed to retrospective analyses of existing medical records, group B. Analyses of the optic discs were made in fundus photographs from 53 patients comparing a semi-automated (Retinal Size Tool) and a manual method (Zeki). There was a strong curvilinear correlation (r(S) = 0.91 p < 0.0001 for both eyes). Behavioural problems were more common (p < 0.05) in bilateral ONII.
   Conclusion: Optic nerve hypoplasia is a common ocular malformation with a prevalence of 17.3/100 000 children and adolescents <18 years of age in Stockholm. Unilateral ONH seems as common as bilateral.
C1 [Fahnehjelm, Kristina Tear] Karolinska Univ Hosp, Dept Clin Neurosci, Karolinska Inst, Stockholm, Sweden.
   [Fahnehjelm, Kristina Tear] Karolinska Univ Hosp, St Erik Eye Hosp, Dept Paediat Ophthalmol & Strabismus, Stockholm, Sweden.
   [Dahl, Sara] Karolinska Univ Hosp, Dept Paediat, Stockholm, Sweden.
   [Martin, Lene] Malardalen Univ, Sch Hlth Care & Social Welf, Eskilstuna, Sweden.
   [Ek, Ulla] Stockholm Univ, Dept Special Educ, S-10691 Stockholm, Sweden.
RP Fahnehjelm, KT (reprint author), Karolinska Univ Hosp, Dept Clin Neuroscienc, Karolinska Inst, Stockholm, Sweden.
EM kristina.tear-fahnehjelm@sankterik.se
FU Sigvard och Marianne Bernadotte Foundation; Signhild Engkvist
   Foundation; Samariten Foundation
FX This project has been supported by the Sigvard och Marianne Bernadotte
   Foundation, the Signhild Engkvist Foundation and the Samariten
   Foundation.
CR Ahmad T, 2006, J PEDIATR-US, V148, P78, DOI 10.1016/j.jpeds.2005.08.050
   Alvarez E, 1988, J Pediatr Ophthalmol Strabismus, V25, P151
   Bartling H, 2008, ACTA OPHTHALMOL, V86, P837, DOI 10.1111/j.1755-3768.2007.01146.x
   Birkebaek NH, 2003, J CLIN ENDOCR METAB, V88, P5281, DOI 10.1210/jc.2003-030527
   Blohme J, 1997, ACTA OPHTHALMOL SCAN, V75, P199
   Blohme J, 2000, ACTA OPHTHALMOL SCAN, V78, P416, DOI 10.1034/j.1600-0420.2000.078004416.x
   Blohme J, 1997, ACTA OPHTHALMOL SCAN, V75, P681
   Borchert M, 2012, J NEURO-OPHTHALMOL, V32, P58, DOI 10.1097/WNO.0b013e31824442b8
   Borchert M, 2008, CURR NEUROL NEUROSCI, V8, P395, DOI 10.1007/s11910-008-0061-7
   BRODSKY MC, 1993, ARCH OPHTHALMOL-CHIC, V111, P66
   BURKE JP, 1991, BRIT J OPHTHALMOL, V75, P236, DOI 10.1136/bjo.75.4.236
   Capo H, 2011, J AAPOS, V15, P281, DOI 10.1016/j.jaapos.2011.02.010
   Ek U, 2005, ACTA PAEDIATR, V94, P1421, DOI 10.1080/08035250510037290
   Fard M A, 2010, Pediatr Endocrinol Rev, V8, P18
   Fink C, 2011, J VISUAL IMPAIR BLIN, V105, P334
   FRISEN L, 1978, BRIT J OPHTHALMOL, V62, P7, DOI 10.1136/bjo.62.1.7
   Frisen L, 2002, VISION RES, V42, P1931, DOI 10.1016/S0042-6989(02)00102-5
   Garcia-Filion P, 2010, ACTA OPHTHALMOL, V88, P527, DOI 10.1111/j.1755-3768.2008.01450.x
   Garcia-Filion P, 2008, PEDIATRICS, V121, pE653, DOI 10.1542/peds.2007-1825
   GOGGIN M, 1991, BRIT J OPHTHALMOL, V75, P425, DOI 10.1136/bjo.75.7.425
   Hatton DD, 2007, J AAPOS, V11, P351, DOI 10.1016/j.jaapos.2007.01.107
   Hellgren K, 2009, ACTA OPHTHALMOL, V87, P843, DOI 10.1111/j.1755-3768.2008.01365.x
   Hellstrom A, 1999, J AAPOS, V3, P212, DOI 10.1016/S1091-8531(99)70005-4
   HOYT WF, 1970, LANCET, V1, P893
   JAN JE, 1977, DEV MED CHILD NEUROL, V19, P353
   Khan R I, 2007, Ir Med J, V100, P458
   Kim MR, 2006, JPN J OPHTHALMOL, V50, P250, DOI 10.1007/s10384-006-0310-8
   Korkman M, 2001, DEV NEUROPSYCHOL, V20, P331, DOI 10.1207/S15326942DN2001_2
   LAMBERT SR, 1987, SURV OPHTHALMOL, V32, P1, DOI 10.1016/0039-6257(87)90069-5
   Ma NS, 2010, J PEDIATR ENDOCR MET, V23, P53
   Magnus H, 1884, MONATSBL AUGENHLKDE, V7, P85
   MARGALITH D, 1985, AM J DIS CHILD, V139, P361
   MARGALITH D, 1984, DEV MED CHILD NEUROL, V26, P311
   Martin L, 2005, ACTA OPHTHALMOL SCAN, V83, P670, DOI 10.1111/j.1600-0420.2005.00569.x
   Martin L, 2004, J GLAUCOMA, V13, P268, DOI 10.1097/00061198-200408000-00002
   Martin LM, 2007, J PEDIAT OPHTH STRAB, V44, P223
   OUVRIER R, 1986, J CHILD NEUROL, V1, P181, DOI 10.1177/088307388600100302
   Pakrou N, 2008, J GLAUCOMA, V17, P43, DOI 10.1097/IJG.0b013e318133fb32
   Parr JR, 2010, DEV MED CHILD NEUROL, V52, P917, DOI 10.1111/j.1469-8749.2010.03664.x
   Patel L, 2006, J PEDIATR-US, V148, P85, DOI 10.1016/j.jpeds.2005.07.031
   Ribeiro IM, 2007, EUR J OPHTHALMOL, V17, P104
   Rivkees SA, 2010, BRIT J OPHTHALMOL, V94, P1358, DOI 10.1136/bjo.2009.175851
   Robaei D, 2006, AM J OPHTHALMOL, V142, P112, DOI 10.1016/j.ajo.2006.02.042
   Stromland K, 2004, ADDICT BIOL, V9, P15
   Stromland K, 2004, ADDICT BIOL, V9, P159
   Tornqvist K, 2002, ACTA OPHTHALMOL SCAN, V80, P300, DOI 10.1034/j.1600-0420.2002.800313.x
   Trillingsgaard A, 2004, EUR CHILD ADOLES PSY, V13, P39, DOI 10.1007/s00787-004-3006-y
   WILLIAMS J, 1993, DEV MED CHILD NEUROL, V35, P490
   ZEKI SM, 1992, J PEDIATR OPHTHALMOL, V29, P107
   ZEKI SM, 1991, BRIT J OPHTHALMOL, V75, P538, DOI 10.1136/bjo.75.9.538
NR 50
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-375X
EI 1755-3768
J9 ACTA OPHTHALMOL
JI Acta Ophthalmol.
PD SEP
PY 2014
VL 92
IS 6
BP 563
EP 570
DI 10.1111/aos.12270
PG 8
WC Ophthalmology
SC Ophthalmology
GA AN4VD
UT WOS:000340585800033
ER

PT J
AU Leivonen, S
   Voutilainen, A
   Hinkka-Yli-Salomaki, S
   Timonen-Soivio, L
   Chudal, R
   Gissler, M
   Huttunen, J
   Sourander, A
AF Leivonen, Susanna
   Voutilainen, Arja
   Hinkka-Yli-Salomaki, Susanna
   Timonen-Soivio, Laura
   Chudal, Roshan
   Gissler, Mika
   Huttunen, Jukka
   Sourander, Andre
TI A nationwide register study of the characteristics, incidence and
   validity of diagnosed Tourette syndrome and other tic disorders
SO ACTA PAEDIATRICA
LA English
DT Article
DE Incidence; Register-based study; Tic disorder; Tourette's syndrome;
   Validation
ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS;
   NEURODEVELOPMENTAL DISORDERS; SEVERITY-SCALE; BIRTH COHORT;
   RISK-FACTORS; SCHIZOPHRENIA; EPIDEMIOLOGY; PREVALENCE; AGE
AB Aim: The aim of this study was to describe the characteristics and incidence rates of diagnosed tic disorders in the Finnish Hospital Discharge Register, including changing incidence rates between 1991 and 2010. We also aimed to validate the diagnoses of Tourette's syndrome recorded in the register.
   Methods: Children born between January 1, 1991 and December 31, 2010, who were diagnosed with tic disorders, were identified from the Finnish Hospital Discharge Register (n = 3003). We studied the validity of the Tourette's syndrome diagnoses by reviewing the medical charts of 88 children born since 1997 and carrying out telephone interviews with 55 of their guardians.
   Results: The incidence rates of all diagnosed tic disorders increased during the study period. A comorbid diagnosis of hyperkinetic disorder diagnosis was recorded in 28.2% of the children with Tourette's syndrome, and the validity of the register-based Tourette's syndrome diagnosis was approximately 95%.
   Conclusion: This is the first nationwide study to demonstrate the increasing incidence of all register-based tic disorder diagnoses. The validity of the Tourette's syndrome diagnoses in the Finnish Hospital Discharge Register was good, and the data provided are suitable for use in further register-based studies of tic disorders.
C1 [Leivonen, Susanna; Hinkka-Yli-Salomaki, Susanna; Timonen-Soivio, Laura; Chudal, Roshan; Gissler, Mika; Huttunen, Jukka; Sourander, Andre] Univ Turku, Dept Child Psychiat, Turku, Finland.
   [Leivonen, Susanna; Voutilainen, Arja; Timonen-Soivio, Laura] Univ Helsinki, Childrens Hosp, Helsinki, Finland.
   [Leivonen, Susanna; Voutilainen, Arja; Timonen-Soivio, Laura] Univ Helsinki, Cent Hosp, Helsinki, Finland.
   [Gissler, Mika] Natl Inst Hlth & Welf THL, Helsinki, Finland.
   [Gissler, Mika] Nord Sch Publ Hlth NHV, Gothenburg, Sweden.
   [Sourander, Andre] Turku Univ Hosp, Dept Child Psychiat, FIN-20520 Turku, Finland.
   [Sourander, Andre] UiT, RKBU, Tromso, Norway.
RP Leivonen, S (reprint author), Univ Turku, Dept Child Psychiat, Kliininen Laitos, Turun 20014, Finland.
EM susanna.leivonen@utu.fi
RI Chudal, Roshan/C-1067-2015
FU Sigrid Juselius Foundation; Jane and Aatos Erkko Foundation; Academy of
   Finland
FX We are grateful to families who participated in the interview study and
   the people in Helsinki and Turku University central hospitals and
   Rovaniemi, Jyvaskyla and Mikkeli central hospitals who did help with the
   identification of the children and gathering the data. We would also
   like to thank data manager Juha-Pekka Virtanen and project coordinator
   Tanja Sarlin and Jarna Lindroos at the Department of child psychiatry,
   Turku University hospital. The study was funded by Sigrid Juselius
   Foundation, Jane and Aatos Erkko Foundation and Academy of Finland. On
   behalf of all authors, the corresponding author states that there is no
   conflict of interests.
CR Atladottir HO, 2007, ARCH PEDIAT ADOL MED, V161, P193, DOI 10.1001/archpedi.161.2.193
   Atladottir HO, 2007, EPIDEMIOLOGY, V18, P240, DOI 10.1097/01.ede.0000254064.92806.13
   Cath DC, 2011, EUR CHILD ADOLES PSY, V20, P155, DOI 10.1007/s00787-011-0164-6
   Scahill L., 2009, Morbidity and Mortality Weekly Report, V58, P581
   Chao TK, 2014, BMC PREGNANCY CHILDB, V14, DOI 10.1186/1471-2393-14-53
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Freeman RD, 2000, DEV MED CHILD NEUROL, V42, P436, DOI 10.1017/S0012162200000839
   Gyllenberg D, 2014, PSYCHIAT SERV, V65, P367, DOI 10.1176/appi.ps.201200544
   Hultman CM, 1999, BRIT MED J, V318, P421
   Jokiranta E, 2013, PSYCHIAT RES, V207, P203, DOI 10.1016/j.psychres.2013.01.005
   Kadesjo B, 2000, J AM ACAD CHILD PSY, V39, P548, DOI 10.1097/00004583-200005000-00007
   KEILP JG, 1995, SCHIZOPHR RES, V17, P221, DOI 10.1016/0920-9964(94)00092-M
   Knight T, 2012, PEDIATR NEUROL, V47, P77, DOI 10.1016/j.pediatrneurol.2012.05.002
   Lampi KM, 2013, J AUTISM DEV DISORD, V43, P2526, DOI 10.1007/s10803-013-1801-3
   Lampi KM, 2010, ACTA PAEDIATR, V99, P1425, DOI 10.1111/j.1651-2227.2010.01835.x
   Lampi KM, 2012, J PEDIATR-US, V161, P830, DOI 10.1016/j.jpeds.2012.04.058
   LECKMAN JF, 1989, J AM ACAD CHILD PSY, V28, P566, DOI 10.1097/00004583-198907000-00015
   Munk-Jorgensen P, 2011, SCAND J PUBLIC HEALT, V39, P170, DOI 10.1177/1403494810390728
   Nielsen PR, 2013, SCHIZOPHRENIA BULL, V39, P1337, DOI 10.1093/schbul/sbs148
   Pendlebury ST, 2013, STROKE, V44, P227, DOI 10.1161/STROKEAHA.112.673384
   Robertson MM, 2008, J PSYCHOSOM RES, V65, P461, DOI 10.1016/j.jpsychores.2008.03.006
   Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
   Savio K, 2013, NEUROL INT, V5, P6
   Scharf J, 2011, J AM ACAD CHILD ADOL, V5, P192
   Shilon Y, 2008, EUR J PAEDIATR NEURO, V12, P398, DOI 10.1016/j.ejpn.2007.10.006
   Storch EA, 2005, PSYCHOL ASSESSMENT, V17, P486, DOI 10.1037/1040-3590.17.4.486
   Sund R, 2012, SCAND J PUBLIC HEALT, V40, P505, DOI 10.1177/1403494812456637
   Tran PL, 2013, PAEDIATR PERINAT EP, V27, P266, DOI 10.1111/ppe.12043
   World Health Organization (WHO), 1992, INT CLASS DIS 10 REV
NR 30
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD SEP
PY 2014
VL 103
IS 9
BP 984
EP 990
DI 10.1111/apa.12708
PG 7
WC Pediatrics
SC Pediatrics
GA AO2GQ
UT WOS:000341136400024
PM 24862980
ER

PT J
AU Glidden, LM
   Grein, KA
   Ludwig, JA
AF Glidden, Laraine Masters
   Grein, Katherine Anne
   Ludwig, Jesse Andrew
TI The Down Syndrome Advantage: It Depends on What and When You Measure
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Down syndrome advantage; intellectual/developmental disability; family
   adjustment; family expectations; adaptive behavior; longitudinal method;
   stereotypes
ID DEVELOPMENTAL-DISABILITIES; INTELLECTUAL DISABILITY; SYNDROME
   SPECIFICITY; PRESCHOOL-CHILDREN; BEHAVIOR PROBLEMS; MOTHERS; FAMILY;
   AUTISM; VULNERABILITY; PERSPECTIVES
AB A "Down syndrome advantage''-better outcomes for individuals with Down syndrome and their families than for those with other intellectual/developmental disabilities (IDD)-is reduced when variables confounded with diagnostic category are controlled. We compared maternal outcomes in a longitudinal sample of families rearing children with Down syndrome or other IDD, and found that a Down syndrome advantage is (a) most likely when the metric is about the son/daughter rather than the parent or family more globally, (b) may be present or absent at different ages, and (c) is partially explained by higher levels of adaptive behavior for individuals with Down syndrome. We discuss the importance of multiple measures at multiple times, and implications for family expectations and adjustment at various life stages.
C1 [Glidden, Laraine Masters; Grein, Katherine Anne; Ludwig, Jesse Andrew] St Marys Coll Maryland, Dept Psychol, St Marys City, MD 20686 USA.
RP Glidden, LM (reprint author), St Marys Coll Maryland, Dept Psychol, 18952 E Fisher Rd, St Marys City, MD 20686 USA.
EM lmglidden@smcm.edu
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
   Acharya K, 2011, DEV DISABIL RES REV, V17, P27, DOI 10.1002/ddrr.135
   Andrews F. M., 1976, SOCIAL INDICATORS WE
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561
   Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
   Bostrom PK, 2011, RES DEV DISABIL, V32, P1860, DOI 10.1016/j.ridd.2011.03.017
   Cahill BM, 1996, AM J MENT RETARD, V101, P149
   Corrice AM, 2009, AJIDD-AM J INTELLECT, V114, P254, DOI 10.1352/1944-7558-114.4.254-268
   Cossman JS, 2011, SOCIOL SPECTRUM, V31, P141, DOI 10.1080/02732173.2011.541339
   Costa P. T., 1992, REVISED NEO PERSONAL
   Cuskelly M., 2009, DOWN SYNDROME RES PR, V12, P202
   Derogatis L. R., 1983, SCL 90 ADM SCORING P
   Down JLH, 1866, LONDON HOSPITAL CLIN, V3, P259
   Dykens EM, 1999, INT REV RES MENT RET, V22, P1, DOI 10.1016/S0074-7750(08)60129-9
   Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
   Esbensen AJ, 2011, AJIDD-AM J INTELLECT, V116, P3, DOI 10.1352/1944-7558-116.1.3
   Fidler D. J., 2009, DOWN SYNDROME RES PR, V12, P188
   Garcia E. G., 2009, YO TAMBIEN
   Glidden L. M., 1998, ADOPTION Q, V1, P27, DOI 10.1300/J145v01n03_03
   Glidden LM, 2012, INT REV RES DEV DISA, V43, P219, DOI 10.1016/B978-0-12-398261-2.00006-4
   Glidden LM, 2007, AM J MENT RETARD, V112, P275, DOI 10.1352/0895-8017(2007)112[275:MPDRAW]2.0.CO;2
   Glidden LM, 2009, INT REV RES MENT RET, V37, P61, DOI 10.1016/S0074-7750(09)37003-2
   Glidden LM, 1997, AM J MENT RETARD, V102, P250, DOI 10.1352/0895-8017(1997)102<0250:DPDAFS>2.0.CO;2
   Graziano A. M., 2002, DEV DISABILITIES INT
   Griffith GM, 2010, J AUTISM DEV DISORD, V40, P610, DOI 10.1007/s10803-009-0906-1
   Helff CM, 1998, MENT RETARD, V36, P457, DOI 10.1352/0047-6765(1998)036<0457:MPOLNT>2.0.CO;2
   Hodapp R. M., 1996, SYNDROME Q, V1, P1
   Holroyd J., 1987, QUESTIONNAIRE RESOUR
   Lambert N, 1993, AAMR ADAPTIVE BEHAV
   Lewis E., 2006, DOWN SYNDROME RES PR, V9, P45
   McCrae R. R., 2007, J INDIVID DIFFER, V28, P116, DOI [10.1027/1614-0001.28.3.116, DOI 10.1027/1614-0001.28.3.116]
   Nelson T. D., 2010, TXB PEDIAT PSYCHOSOM, P173
   Pisula E, 2007, J APPL RES INTELLECT, V20, P274, DOI 10.1111/j.1468-3148.2006.00342.x
   Povee K, 2012, J INTELL DISABIL RES, V56, P961, DOI 10.1111/j.1365-2788.2012.01561.x
   Schuz B, 2011, QUAL LIFE RES, V20, P1573, DOI 10.1007/s11136-011-9909-4
   SELTZER MM, 1993, AM J MENT RETARD, V97, P496
   Skotko BG, 2011, AM J MED GENET A, V155A, P2335, DOI 10.1002/ajmg.a.34293
   Stoneman Z, 2007, J INTELL DISABIL RES, V51, P1006, DOI 10.1111/j.1365-2788.2007.01012.x
   U. S. Bureau of the Census, 2012, INC POV HLTH INS COV
   World Health Organization, 2012, GEN HUM DIS SYNDR
NR 40
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2014
VL 119
IS 5
BP 389
EP 404
DI 10.1352/1944-7558-119.5.389
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XQ
UT WOS:000341271000001
PM 25148054
ER

PT J
AU Totsika, V
   Hastings, RP
   Vagenas, D
   Emerson, E
AF Totsika, Vasiliki
   Hastings, Richard Patrick
   Vagenas, Dimitrios
   Emerson, Eric
TI Parenting and the Behavior Problems of Young Children With an
   Intellectual Disability: Concurrent and Longitudinal Relationships in a
   Population-Based Study
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE intellectual disability; parenting; longitudinal; parent-child
   relationship
ID AUTISM SPECTRUM DISORDER; MATERNAL MENTAL-HEALTH; STONES TRIPLE P;
   DIFFICULTIES QUESTIONNAIRE; MIDDLE CHILDHOOD; DEVELOPMENTAL-DISABILITY;
   RELATIONSHIP QUALITY; EMOTIONAL-PROBLEMS; SYMPTOMS; CHAOS
AB We examined parenting behaviors, and their association with concurrent and later child behavior problems. Children with an intellectual disability (ID) were identified from a UK birth cohort (N = 516 at age 5). Compared to parents of children without an ID, parents of children with an ID used discipline less frequently, but reported a more negative relationship with their child. Among children with an ID, discipline, and home atmosphere had no long-term association with behavior problems, whereas relationship quality did: closer relationships were associated with fewer concurrent and later child behavior problems. Increased parent-child conflict was associated with greater concurrent and later behavior problems. Parenting programs in ID could target parent-child relationship quality as a potential mediator of behavioral improvements in children.
C1 [Totsika, Vasiliki; Hastings, Richard Patrick] Univ Warwick, Coventry CV4 7AL, W Midlands, England.
   [Vagenas, Dimitrios] Queensland Univ Technol, Brisbane, Qld 4001, Australia.
   [Emerson, Eric] Univ Sydney, Sydney, NSW 2006, Australia.
   [Emerson, Eric] Univ Lancaster, Lancaster LA1 4YW, England.
RP Totsika, V (reprint author), Univ Warwick, CEDAR, Westwood Campus, Coventry CV4 7AL, W Midlands, England.
EM V.Totsika@warwick.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR Asbury K, 2005, INTELLIGENCE, V33, P643, DOI 10.1016/j.intell.2005.03.008
   Baker JK, 2011, J ABNORM PSYCHOL, V120, P465, DOI 10.1037/a0021900
   Belsky J, 2011, J CHILD PSYCHOL PSYC, V52, P409, DOI 10.1111/j.1469-7610.2010.02281.x
   Blacher J, 2009, AJIDD-AM J INTELLECT, V114, P322, DOI 10.1352/1944-7558-114.5.322
   Blacher J, 2013, J AUTISM DEV DISORD, V43, P761, DOI 10.1007/s10803-012-1605-x
   Brown MA, 2011, J MENT HEALTH RES IN, V4, P206, DOI 10.1080/19315864.2011.596990
   Byrne B. M., 2010, STRUCTURAL EQUATION, V2nd
   CAREY WB, 1978, PEDIATRICS, V61, P735
   Conger RD, 2007, ANNU REV PSYCHOL, V58, P175, DOI 10.1146/annurev.psych.58.110405.085551
   Criss MM, 2003, SOC DEV, V12, P379, DOI 10.1111/1467-9507.00239
   Dallaire DH, 2006, J CLIN CHILD ADOLESC, V35, P313, DOI 10.1207/s15374424jccp3502_15
   Dumas JE, 2005, J CLIN CHILD ADOLESC, V34, P93, DOI 10.1207/s15374424jccp3401_9
   Eisenhower AS, 2007, J SCHOOL PSYCHOL, V45, P363, DOI 10.1016/j.jsp.2006.10.002
   Elliot C. D., 1996, BRIT ABILITY SCALES
   Emerson E, 2005, J INTELLECT DEV DIS, V30, P14, DOI 10.1080/13668250500033169
   Emerson E, 2012, CHILD SOC, V26, P214, DOI 10.1111/j.1099-0860.2012.00434.x
   Emerson E, 2011, J CHILD PSYCHOL PSYC, V52, P1184, DOI 10.1111/j.1469-7610.2011.02413.x
   Evans GW, 2005, PSYCHOL SCI, V16, P560, DOI 10.1111/j.0956-7976.2005.01575.x
   Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Green VA, 2005, RES DEV DISABIL, V26, P47, DOI 10.1016/j.ridd.2004.07.003
   Hart SA, 2007, INTELLIGENCE, V35, P233, DOI 10.1016/j.intell.2006.08.004
   Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
   Hastings RP, 2007, MENT RETARD DEV D R, V13, P339, DOI 10.1002/mrdd.20173
   Hill V., 2005, CHILD ADOL MENT H-UK, V10, P87, DOI 10.1111/j.1475-3588.2004.00123.x
   Hoeve M, 2009, J ABNORM CHILD PSYCH, V37, P749, DOI 10.1007/s10802-009-9310-8
   Hoff E, 2002, HDB PARENTING, V2, P231
   Kalb LM, 2003, PEDIATRICS, V111, P641, DOI 10.1542/peds.111.3.641
   Keown LJ, 2012, J ABNORM CHILD PSYCH, V40, P569, DOI 10.1007/s10802-011-9586-3
   Kiff CJ, 2011, CLIN CHILD FAM PSYCH, V14, P251, DOI 10.1007/s10567-011-0093-4
   Kim HJ, 2005, CHILD FAM BEHAV THER, V27, P23, DOI 10.1300/J019v27n02_03
   Kremer M, 2010, J FAM STUD, V16, P251, DOI 10.5172/jfs.16.3.251
   Kurtz PF, 2012, J MENT HEALTH RES IN, V5, P260, DOI 10.1080/19315864.2011.600809
   Lambrechts G, 2011, RES AUTISM SPECT DIS, V5, P1143, DOI 10.1016/j.rasd.2010.12.011
   MATHENY AP, 1995, J APPL DEV PSYCHOL, V16, P429, DOI 10.1016/0193-3973(95)90028-4
   Mazzucchelli TG, 2011, RES DEV DISABIL, V32, P2148, DOI 10.1016/j.ridd.2011.07.022
   McIntyre LL, 2008, J INTELL DISABIL RES, V52, P1176, DOI 10.1111/j.1365-2788.2008.01108.x
   McLeod BD, 2007, CLIN PSYCHOL REV, V27, P986, DOI 10.1016/j.cpr.2007.03.001
   McLoyd VC, 1998, AM PSYCHOL, V53, P185, DOI 10.1037/0003-066X.53.2.185
   Newland RP, 2011, INFANT CHILD DEV, V20, P371, DOI 10.1002/icd.729
   Orsmond GI, 2006, AM J MENT RETARD, V111, P121, DOI 10.1352/0895-8017(2006)111[121:MRQAAA]2.0.CO;2
   Osborne LA, 2008, RES AUTISM SPECT DIS, V2, P249, DOI 10.1016/j.rasd.2007.06.004
   Pianta R. C., 1992, CHILD PARENT RELATIO
   Plewis I., 2007, MILLENNIUM COHORT ST, V4th
   Puma Michael, 2010, HEAD START IMPACT ST
   Sameroff A., 2009, T MODEL DEV CHILDREN, P3, DOI [10.1037/11877-001, DOI 10.1037/11877-001]
   Sanders MR, 2012, ANNU REV CLIN PSYCHO, V8, P345, DOI 10.1146/annurev-clinpsy-032511-143104
   Smith LE, 2008, AM J MENT RETARD, V113, P387, DOI 10.1352/2008.113:387-402
   Sofronoff K, 2011, RES DEV DISABIL, V32, P2253, DOI 10.1016/j.ridd.2011.07.046
   Sterling A, 2012, AJIDD-AM J INTELLECT, V117, P194, DOI 10.1352/1944-7558-117.3.194
   Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
   Totsika V, 2011, J ABNORM CHILD PSYCH, V39, P1137, DOI 10.1007/s10802-011-9534-2
   Trentacosta CJ, 2011, CHILD DEV, V82, P1676, DOI 10.1111/j.1467-8624.2011.01626.x
   Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
NR 54
TC 1
Z9 1
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2014
VL 119
IS 5
BP 422
EP 435
DI 10.1352/1944-7558-119.5.422
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XQ
UT WOS:000341271000003
PM 25148056
ER

PT J
AU Shire, SY
   Kasari, C
AF Shire, Stephanie Yoshiko
   Kasari, Connie
TI Train the Trainer Effectiveness Trials of Behavioral Intervention for
   Individuals With Autism: A Systematic Review
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE effectiveness trials; Train-the-Trainer; autism; intervention
ID JOINT ATTENTION INTERVENTION; SPECTRUM DISORDERS; PSYCHOSOCIAL
   INTERVENTIONS; FOLLOW-UP; CHILDREN; PSYCHOTHERAPY; PRESCHOOLERS;
   PROGRAM; MODEL
AB This systematic review examines train the trainer (TTT) effectiveness trials of behavioral interventions for individuals with autism spectrum disorder (ASD). Published methodological quality scales were used to assess studies including participant description, research design, intervention, outcomes, and analysis. Twelve studies including 9 weak quality quasi-experimental studies, 2 single-subject experimental design studies of moderate and weak quality, and 1 high quality randomized control trial were included. Overall, author reported effect sizes and calculation of improvement rate difference for SSRDs indicate positive effects of intervention across participant outcomes including cognition, language, and autism symptoms postcommunity delivered interventions primarily based in applied behavior analysis. Effects varied by children's developmental level.
C1 [Shire, Stephanie Yoshiko; Kasari, Connie] Univ Calif Los Angeles, Los Angeles, CA 90095 USA.
RP Shire, SY (reprint author), Univ Calif Los Angeles, Neuropsychiat Inst 67 448, 760 Westwood Plaza, Los Angeles, CA 90095 USA.
EM sypatterson@ucla.edu
CR American Academy of Cerebral Palsy and Developmental Medicine, 2008, METHODOLOGY TO DEVEL
   Brookman-Frazee LI, 2012, J AUTISM DEV DISORD, V42, P1651, DOI 10.1007/s10803-011-1406-7
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
   Flanagan HE, 2012, RES AUTISM SPECT DIS, V6, P673, DOI 10.1016/j.rasd.2011.09.011
   Gersten R, 2005, EXCEPT CHILDREN, V71, P149
   Higgins J. P. T., 2011, THE COCHRANE COLLABO
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Ingersoll BR, 2013, AUTISM, V17, P434, DOI 10.1177/1362361311427155
   Kaale A, 2012, J CHILD PSYCHOL PSYC, V53, P97, DOI 10.1111/j.1469-7610.2011.02450.x
   Kasari C, 2012, CURR PSYCHIAT REP, V14, P713, DOI 10.1007/s11920-012-0317-4
   Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
   Kasari C, 2013, AUTISM, V17, P254, DOI 10.1177/1362361312470496
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Kern Petra, 2006, J Music Ther, V43, P270
   Lawton K, 2012, J CONSULT CLIN PSYCH, V80, P687, DOI 10.1037/a0028506
   Logan LR, 2008, DEV MED CHILD NEUROL, V50, P99, DOI 10.1111/j.1469-8749.2007.02005.x
   Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
   Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
   National Autism Center, 2009, NATIONAL STANDARDS R
   Ospina MB, 2008, PLOS ONE, V3, P1, DOI DOI 10.1371/JOURNAL.PONE.0003755
   Palmen A, 2010, RES AUTISM SPECT DIS, V4, P731, DOI 10.1016/j.rasd.2010.01.012
   Parker RI, 2009, EXCEPT CHILDREN, V75, P135
   Patterson SY, 2012, AUTISM, V16, P498, DOI 10.1177/1362361311413398
   Perry A, 2008, RES AUTISM SPECT DIS, V2, P621, DOI 10.1016/j.rasd.2008.01.002
   Reed P, 2007, EXCEPT CHILDREN, V73, P417
   Reichow B, 2012, J AUTISM DEV DISORD, V42, P512, DOI 10.1007/s10803-011-1218-9
   Smith IM, 2010, AJIDD-AM J INTELLECT, V115, P504, DOI [10.1352/1944-7558-115.6.504, 10.1352/194475581156504]
   Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
   Spreckley M, 2009, J PEDIATR-US, V154, P338, DOI 10.1016/j.jpeds.2008.09.012
   Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
   Weisz J. R., 2001, EUROPEAN CHILD AND A, V10, p1/12
   WEISZ JR, 1992, AM PSYCHOL, V47, P1578, DOI 10.1037/0003-066X.47.12.1578
   Weisz JR, 2012, ARCH GEN PSYCHIAT, V69, P274, DOI 10.1001/archgenpsychiatry.2011.147
   World Health Organization, 2005, MENTAL HEALTH POLICY
NR 34
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2014
VL 119
IS 5
BP 436
EP 451
DI 10.1352/1944-7558-119.5.436
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XQ
UT WOS:000341271000004
PM 25148057
ER

PT J
AU Lieberman-Betz, RG
   Yoder, P
   Stone, WL
   Nahmias, AS
   Carter, AS
   Celimli-Aksoy, S
   Messinger, DS
AF Lieberman-Betz, Rebecca G.
   Yoder, Paul
   Stone, Wendy L.
   Nahmias, Allison S.
   Carter, Alice S.
   Celimli-Aksoy, Seniz
   Messinger, Daniel S.
TI An Illustration of Using Multiple Imputation Versus Listwise Deletion
   Analyses: The Effect of Hanen's "More Than Words'' on Parenting Stress
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE missing data analysis; multiple imputation; autism spectrum disorder;
   early intervention; parent stress
ID AUTISM SPECTRUM DISORDERS; RANDOMIZED CONTROLLED-TRIAL; MISSING-DATA;
   YOUNG-CHILDREN; 2-YEAR-OLDS STAT; MATERNAL STRESS; SCREENING TOOL;
   FAMILY STRESS; MENTAL-HEALTH; INTERVENTION
AB This investigation illustrates the effects of using different missing data analysis techniques to analyze effects of a parent-implemented treatment on stress in parents of toddlers with autism symptomatology. The analysis approaches yielded similar results when analyzing main effects of the intervention, but different findings for moderation effects. Using listwise deletion, the data supported an iatrogenic effect of Hanen's "More Than Words'' on stress in parents with high levels of pretreatment depressive symptoms. Using multiple imputation, a significant moderated treatment effect with uninterpretable regions of significance did not support an iatrogenic effect of treatment on parenting stress. Results highlight the need for caution in interpreting analyses that do not involve validated methods of handling missing data.
C1 [Lieberman-Betz, Rebecca G.; Yoder, Paul] Vanderbilt Univ, Peabody Coll, Dept Special Educ, Nashville, TN USA.
   [Stone, Wendy L.] Vanderbilt Univ, Dept Pediat, Nashville, TN USA.
   [Nahmias, Allison S.] Vanderbilt Univ, Nashville, TN USA.
   [Carter, Alice S.] Univ Massachusetts Boston, Dept Psychol, Boston, MA USA.
   [Celimli-Aksoy, Seniz; Messinger, Daniel S.] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
RP Lieberman-Betz, RG (reprint author), Univ Georgia, Dept Commun Sci & Special Educ, 565 Aderhold Hall, Athens, GA 30602 USA.
EM rglb@uga.edu
CR Abidin RR, 1995, PARENTING STRESS IND
   Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
   Baraldi AN, 2010, J SCHOOL PSYCHOL, V48, P5, DOI 10.1016/j.jsp.2009.10.001
   Barnes SA, 2006, STAT MED, V25, P233, DOI 10.1002/sim.2231
   Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
   BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6
   BRINKER RP, 1994, AM J MENT RETARD, V98, P463
   Buhi ER, 2008, AM J HEALTH BEHAV, V32, P83
   Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   DONENBERG G, 1993, J ABNORM CHILD PSYCH, V21, P179, DOI 10.1007/BF00911315
   Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
   Enders CK, 2011, PSYCHOL METHODS, V16, P1, DOI 10.1037/a0022640
   Enders CK, 2010, APPL MISSING DATA AN
   Estes A, 2013, BRAIN DEV-JPN, V35, P133, DOI 10.1016/j.braindev.2012.10.004
   Goin-Kochel RP, 2006, AUTISM, V10, P439, DOI 10.1177/1362361306066601
   Graham J. W., 2003, RES METHODS PSYCHOL, V2, P87
   Graham JW, 1999, STAT STRATEGIES SMAL, P1
   Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530
   Hastings RP, 2001, J AUTISM DEV DISORD, V31, P327, DOI 10.1023/A:1010799320795
   Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
   HOLROYD J, 1976, AM J MENT DEF, V80, P431
   Horton NJ, 2007, AM STAT, V61, P79, DOI 10.1198/000313007X172556
   Ibrahim JG, 2005, J AM STAT ASSOC, V100, P332, DOI 10.1198/016214504000001844
   Ingersoll B, 2007, RES DEV DISABIL, V28, P163, DOI 10.1016/j.ridd.2006.02.004
   Lachin JM, 2000, CONTROL CLIN TRIALS, V21, P167, DOI 10.1016/S0197-2456(00)00046-5
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Little RJA, 2002, STAT ANAL MISSING DA, V2nd
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Meadan H, 2009, TOP EARLY CHILD SPEC, V29, P90, DOI 10.1177/0271121409337950
   Moher D, 2001, ANN INTERN MED, V134, P657
   Mullen E, 1995, MULLEN SCALES EARLY
   NEWELL DJ, 1992, INT J EPIDEMIOL, V21, P837, DOI 10.1093/ije/21.5.837
   Newman DA, 2003, ORGAN RES METHODS, V6, P328, DOI 10.1177/1094428103254673
   NOH S, 1989, FAM RELAT, V38, P456, DOI 10.2307/585753
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Preacher KJ, 2006, J EDUC BEHAV STAT, V31, P437, DOI 10.3102/10769986031004437
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   RODRIGUE JR, 1990, J CLIN CHILD PSYCHOL, V19, P371, DOI 10.1207/s15374424jccp1904_9
   RUBIN DB, 1976, BIOMETRIKA, V63, P581, DOI 10.1093/biomet/63.3.581
   Sameroff A. J., 1989, RELATIONSHIP DISTURB
   Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Schlomer GL, 2010, J COUNS PSYCHOL, V57, P1, DOI 10.1037/a0018082
   Shadish W, 2002, EXPT QUASIEXPERIMENT
   Sparrow SS, 2005, VINELAND 2 VINELAND
   Stone WL, 2004, J AUTISM DEV DISORD, V34, P691, DOI 10.1007/s10803-004-5289-8
   Stone WL, 2008, AUTISM, V12, P557, DOI 10.1177/1362361308096403
   Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002
   Sussman F., 2004, MORE WORDS HELPING P
   Tabachnick B., 2007, USING MULTIVARIATE S, V5th
   Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
   Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
   Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
   von Hippel PT, 2009, SOCIOL METHODOL, V39, P265
   Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
   What Works Clearinghouse, 2010, PROCEDURES STANDARDS
   What Works Clearinghouse, 2014, PROCEDURES STANDARDS
   Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
   WOLF LC, 1989, J AUTISM DEV DISORD, V19, P157, DOI 10.1007/BF02212727
   Wong VCN, 2010, J AUTISM DEV DISORD, V40, P677, DOI 10.1007/s10803-009-0916-z
   Wood Angela M, 2004, Clin Trials, V1, P368, DOI 10.1191/1740774504cn032oa
NR 64
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2014
VL 119
IS 5
BP 472
EP 486
DI 10.1352/1944-7558-119.5.472
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XQ
UT WOS:000341271000006
PM 25148059
ER

PT J
AU Ogata, H
   Ihara, H
   Murakami, N
   Gito, M
   Kido, Y
   Nagai, T
AF Ogata, Hiroyuki
   Ihara, Hiroshi
   Murakami, Nobuyuki
   Gito, Masao
   Kido, Yasuhiro
   Nagai, Toshiro
TI Autism Spectrum Disorders and Hyperactive/Impulsive Behaviors in
   Japanese Patients With Prader-Willi Syndrome: A Comparison Between
   Maternal Uniparental Disomy and Deletion Cases
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE Prader-Willi syndrome; chromosome 15q11-13; autism spectrum disorders;
   maternal uniparental disomy 15 (mUPD); adolescents
ID PERVASIVE DEVELOPMENTAL DISORDERS; ABILITIES; CHILDREN
AB This study aims to compare maternal uniparental disomy 15 (mUPD) and a paternal deletion of 15q11-13 (DEL) of Prader-Willi syndrome (PWS) in regard to autism spectrum disorders (ASD). Forty-five Japanese individuals with PWS were recruited from a single recruitment center. The participants consisted of 22 children (aged from 6 to 12) and 23 adolescents (aged from 13 to 19). Six children and seven adolescents were confirmed as having mUPD. Sixteen children and 16 adolescents were confirmed as having DEL. Under blindness to the participants' genotypes, a single psychologist carried out behavioral and psychological assessments, including the Wechsler Intelligence Scales, Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS), and ADHD-Rating Scale-IV (ADHD-RS-IV). Two comparisons were made: one between mUPD and DEL children and another between mUPD and DEL adolescents. In children, no significant differences were found between mUPD and DEL participants in terms of autistic (PARS childhood, P = 0.657) and impulsive behaviors (ADHD-RS-IV hyperactive/impulsive, P = 0.275). In adolescents, mUPD patients showed significantly more autistic symptomatology (PARS adolescent, P = 0.027) and significantly more impulsive behavior (ADHD-RS-IV hyperactive/impulsive, P = 0.01) than DEL patients. Our findings about Japanese PWS patients were consistent with previous researches from western countries not focused on Asian patients, indicating that mUPD cases would be more prone to ASD than DEL cases, regardless of ethnoregional differences. In addition, our data suggested that the behavioral difference between mUPD and DEL cases in terms of autistic and impulsive symptoms tend to be unrecognizable in their childhood. (C) 2014 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc.
C1 [Ogata, Hiroyuki; Ihara, Hiroshi; Gito, Masao] Dokkyo Med Univ, Dept Psychiat, Koshigaya Hosp, Koshigaya, Japan.
   [Murakami, Nobuyuki; Kido, Yasuhiro; Nagai, Toshiro] Dokkyo Med Univ, Dept Pediat, Koshigaya Hosp, Koshigaya, Japan.
   [Gito, Masao] Ikezawa Hosp, Dept Psychiat, Hanyu, Japan.
RP Ihara, H (reprint author), Dokkyo Med Univ, Dept Psychiat, Koshigaya Hosp, Minami Koshigaya 2-1-50, Koshigaya, Japan.
EM cotoncb@dokkyomed.ac.jp
FU Juntendo Institute of Psychiatry [Heisei 25]
FX This research was supported by a grant for Research Support Foundation
   from the Juntendo Institute of Psychiatry in the financial year 2013
   (Heisei 25).
CR Adachi J, 2006, RINSYOSEISHINIGAKU, V35, P1591
   Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Bolton PF, 2001, AM J MED GENET, V105, P675, DOI 10.1002/ajmg.1551
   Cassidy SB, 1997, J MED GENET, V34, P917, DOI 10.1136/jmg.34.11.917
   Descheemaeker MJ, 2002, J INTELL DISABIL RES, V46, P41, DOI 10.1046/j.1365-2788.2002.00354.x
   Descheemaeker MJ, 2006, AM J MED GENET A, V140A, P1136, DOI 10.1002/ajmg.a.31235
   DuPaul JG, 1998, ADHD RATING SCALE 4
   DYKENS EM, 1992, J AM ACAD CHILD PSY, V31, P1125, DOI 10.1097/00004583-199211000-00022
   Dykens EM, 2011, J NEURODEV DISORD, V3, P225, DOI 10.1007/s11689-011-9092-5
   Greaves N, 2006, J INTELL DISABIL RES, V50, P92, DOI 10.1111/j.1365-2788.2005.00726.x
   Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
   Ichikawa H, 2008, ADHD RATING SCALE 4
   Ito H, 2012, RES AUTISM SPECT DIS, V6, P1265, DOI 10.1016/j.rasd.2012.04.002
   Japanese WAIS-III Publication Committee, 2006, NIH WAIS 3 CHIN KENS
   Japanese WISC-III Publication Committee, 1998, NIH WISC 3 CHIN KENS
   Kamio Y., 2006, SEISHIN IGAKU, V48, P495
   KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
   Milner KM, 2005, J CHILD PSYCHOL PSYC, V46, P1089, DOI 10.1111/j.1469-7610.2005.01520.x
   Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
   Roof E, 2000, J INTELL DISABIL RES, V44, P25, DOI 10.1046/j.1365-2788.2000.00250.x
   Dimitropoulos Anastasia, 2007, Curr Psychiatry Rep, V9, P159
   Shu SG, 2007, J FORMOS MED ASSOC, V106, P509
   Veltman MWM, 2004, EUR CHILD ADOLES PSY, V13, P42, DOI 10.1007/s00787-004-0354-6
   Veltman MWM, 2005, PSYCHIAT GENET, V15, P243, DOI 10.1097/00041444-200512000-00006
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Wechsler D, 1991, WECHSLAR INTELLIGENC
   Whittington J, 2004, J INTELL DISABIL RES, V48, P172, DOI 10.1111/j.1365-2788.2004.00556.x
   Wigren M, 2005, J INTELL DISABIL RES, V49, P449, DOI 10.1111/j.1365-2788.2005.00690.x
   Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x
NR 29
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD SEP
PY 2014
VL 164A
IS 9
BP 2180
EP 2186
DI 10.1002/ajmg.a.36615
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AN5YO
UT WOS:000340669200007
PM 24850752
ER

PT J
AU Canetta, S
   Sourander, A
   Surcel, HM
   Hinkka-Yli-Salomaki, S
   Leiviska, J
   Kellendonk, C
   McKeague, IW
   Brown, AS
AF Canetta, Sarah
   Sourander, Andre
   Surcel, Helja-Marja
   Hinkka-Yli-Salomaki, Susanna
   Leiviska, Jaana
   Kellendonk, Christoph
   McKeague, Ian W.
   Brown, Alan S.
TI Elevated Maternal C-Reactive Protein and Increased Risk of Schizophrenia
   in a National Birth Cohort
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; PRENATAL IMMUNE ACTIVATION; INFLUENZA
   EPIDEMIC; BRAIN-DEVELOPMENT; BIPOLAR DISORDER; ANIMAL-MODELS; EXPOSURE;
   INFECTION; PREECLAMPSIA; PREGNANCY
AB Objective: The objective of the present study was to investigate an association between early gestational C-reactive protein, an established inflammatory biomarker, prospectively assayed in maternal sera, and schizophrenia in a large, national birth cohort with an extensive serum biobank.
   Method: A nested case-control design from the Finnish Prenatal Study of Schizophrenia cohort was utilized. A total of 777 schizophrenia cases (schizophrenia, N=630; schizoaffective disorder, N=147) with maternal sera available for C-reactive protein testing were identified and matched to 777 control subjects in the analysis. Maternal C-reactive protein levels were assessed using a latex immunoassay from archived maternal serum specimens.
   Results: Increasing maternal C-reactive protein levels, classified as a continuous variable, were significantly associated with schizophrenia in offspring (adjusted odds ratio=1.31, 95% confidence interval=1.10-1.56). This finding remained significant after adjusting for potential confounders, including maternal and parental history of psychiatric disorders, twin/singleton birth, urbanicity, province of birth, and maternal socioeconomic status.
   Conclusions: This finding provides the most robust evidence to date that maternal inflammation may play a significant role in schizophrenia, with possible implications for identifying preventive strategies and pathogenic mechanisms in schizophrenia and other neurodevelopmental disorders.
C1 [Brown, Alan S.] Columbia Univ, Dept Psychiat, New York State Psychiat Inst, Med Ctr, New York, NY 10027 USA.
   Columbia Univ, Dept Pharmacol, New York State Psychiat Inst, Med Ctr, New York, NY USA.
   Univ Turku, Fac Med, Dept Child Psychiat, Turku, Finland.
   Turku Univ Hosp, Dept Child Psychiat, FIN-20520 Turku, Finland.
   Natl Inst Hlth & Welf, Oulu, Finland.
   Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA.
   Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
RP Brown, AS (reprint author), Columbia Univ, Dept Psychiat, New York State Psychiat Inst, Med Ctr, New York, NY 10027 USA.
EM asb11@columbia.edu
FU NIMH [R01 MH-082052-05, K02 MH-065422-09, T32 MH-16434-31]; State
   Research Institute; Sackler Institute Fellowship
FX Supported by grants R01 MH-082052-05 and K02 MH-065422-09 (to Dr. Brown)
   from NIMH and the State Research Institute and grant T32 MH-16434-31 (to
   Dr. Canetta) from NIMH and the Sackler Institute Fellowship.
CR Abdallah MW, 2012, J NEUROIMMUNOL, V252, P75, DOI 10.1016/j.jneuroim.2012.07.013
   Abdallah MW, 2013, WORLD J BIOL PSYCHIA, V14, P528, DOI 10.3109/15622975.2011.639803
   Arikan DC, 2012, J MATERN-FETAL NEO M, V25, P1569, DOI 10.3109/14767058.2011.648233
   Ashdown H, 2006, MOL PSYCHIATR, V11, P47, DOI 10.1038/sj.mp.4001748
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Benros ME, 2011, AM J PSYCHIAT, V168, P1303, DOI 10.1176/appi.ajp.2011.11030516
   Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
   Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
   Brown AS, 2000, AM J PSYCHIAT, V157, P438, DOI 10.1176/appi.ajp.157.3.438
   Brown AS, 2004, ARCH GEN PSYCHIAT, V61, P774, DOI 10.1001/archpsyc.61.8.774
   Brown AS, 2013, MOL PSYCHIAT
   Brown AS, 2004, AM J PSYCHIAT, V161, P889, DOI 10.1176/appi.ajp.161.5.889
   Brown AS, 2005, AM J PSYCHIAT, V162, P767, DOI 10.1176/appi.ajp.162.4.767
   Buka SL, 2001, BRAIN BEHAV IMMUN, V15, P411, DOI 10.1006/brbi.2001.0644
   Buka SL, 2008, BIOL PSYCHIAT, V63, P809, DOI 10.1016/j.biopsych.2007.09.022
   Canetta SE, 2014, AM J PSYCHIAT, V171, P557, DOI 10.1176/appi.ajp.2013.13070943
   Clarke MC, 2009, AM J PSYCHIAT, V166, P1025, DOI 10.1176/appi.ajp.2009.08010031
   Ernst GD, 2011, AM J OBSTET GYNECOL, V205
   Flores-Alfaro E, 2012, GENET MOL RES, V11, P2258, DOI 10.4238/2012.May.14.5
   Gabay C, 1999, NEW ENGL J MED, V340, P448
   Giovanoli S, 2013, SCIENCE, V339, P1095, DOI 10.1126/science.1228261
   Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
   Grether JK, 2010, AUTISM RES, V3, P323, DOI 10.1002/aur.160
   Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   Klaning U, 1996, BRIT J PSYCHIAT, V168, P688, DOI 10.1192/bjp.168.6.688
   Lam C, 2005, HYPERTENSION, V46, P1077, DOI 10.1161/01.HYP.0000187899.34379.b0
   LEHTINEN V, 1990, ACTA PSYCHIAT SCAND, V81, P418, DOI 10.1111/j.1600-0447.1990.tb05474.x
   LEWIS G, 1992, LANCET, V340, P137, DOI 10.1016/0140-6736(92)93213-7
   Machon RA, 1997, ARCH GEN PSYCHIAT, V54, P322
   Maki P, 2005, BRIT MED BULL, V73-74, P1, DOI 10.1093/bmb/ldh046
   Makikyro T, 1998, EUR PSYCHIAT, V13, P57, DOI 10.1016/S0924-9338(98)80019-9
   MEDNICK SA, 1988, ARCH GEN PSYCHIAT, V45, P189
   Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
   Mihu D, 2008, Rev Med Chir Soc Med Nat Iasi, V112, P1019
   Mortensen PB, 2010, SCHIZOPHR RES, V122, P257, DOI 10.1016/j.schres.2010.06.010
   Mortensen PB, 2010, PSYCHOL MED, V40, P201, DOI 10.1017/S0033291709990419
   Mortensen PB, 1999, NEW ENGL J MED, V340, P603, DOI 10.1056/NEJM199902253400803
   OCALLAGHAN E, 1991, LANCET, V337, P1248, DOI 10.1016/0140-6736(91)92919-S
   Parboosing R, 2013, JAMA PSYCHIAT, V70, P677, DOI 10.1001/jamapsychiatry.2013.896
   Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
   Redman CWG, 2004, SEMIN NEPHROL, V24, P565, DOI 10.1016/j.semnephrol.2004.07.005
   SHAM PC, 1992, BRIT J PSYCHIAT, V160, P461, DOI 10.1192/bjp.160.4.461
   Sirugo G, 2004, SCHIZOPHR RES, V70, P343, DOI 10.1016/j.schres.2004.01.002
   Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
   Sorensen HJ, 2009, SCHIZOPHRENIA BULL, V35, P631, DOI 10.1093/schbul/sbn121
   Stephan AH, 2012, ANNU REV NEUROSCI, V35, P369, DOI 10.1146/annurev-neuro-061010-113810
   Suvisaari JM, 1999, ARCH GEN PSYCHIAT, V56, P733, DOI 10.1001/archpsyc.56.8.733
NR 49
TC 6
Z9 6
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD SEP
PY 2014
VL 171
IS 9
BP 960
EP 968
DI 10.1176/appi.ajp.2014.13121579
PG 9
WC Psychiatry
SC Psychiatry
GA AO1MU
UT WOS:000341077000013
PM 24969261
ER

PT J
AU McCoy, BM
   Rickert, ME
   Class, QA
   Larsson, H
   Lichtenstein, P
   D'Onofrio, BM
AF McCoy, Brittany M.
   Rickert, Martin E.
   Class, Quetzal A.
   Larsson, Henrik
   Lichtenstein, Paul
   D'Onofrio, Brian M.
TI Mediators of the association between parental severe mental illness and
   offspring neurodevelopmental problems
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Attention deficit hyperactivity disorder; Autism spectrum disorder;
   Infant; Small for gestational age; Birth weight; Gestational age
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS;
   ADVERSE PREGNANCY OUTCOMES; LOW-BIRTH-WEIGHT; RISK-FACTORS;
   PSYCHIATRIC-DISORDERS; BIPOLAR DISORDER; PRETERM BIRTH;
   BRAIN-DEVELOPMENT; GESTATIONAL-AGE
AB Purpose: Parental severe mental illness (SMI) is associated with an increased risk of offspring autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We conducted a study to examine the extent to which risk of preterm birth, low birth weight, and small for gestational age mediated this association.
   Methods: We obtained data on offspring born 1992-2001 in Sweden (n = 870,017) through the linkage of multiple population-based registers. We used logistic and Cox regression to assess the associations between parental SMI, adverse pregnancy outcomes, and offspring ASD and ADHD, as well as tested whether adverse pregnancy outcomes served as mediators.
   Results: After controlling for measured covariates, maternal and paternal SMI were associated with an increased risk for preterm birth, low birth weight, and gestational age, and for offspring ASD and ADHD. These pregnancy outcomes were also associated with an increased risk of ASD and ADHD. We found that pregnancy outcomes did not mediate the association between parental SMI and offspring ASD and ADHD, as there was no substantial change in magnitude of the risk estimates after controlling for pregnancy outcomes.
   Conclusions: Parental SMI and adverse pregnancy outcomes appear to be independent risk factors for offspring ASD and ADHD. (C) 2014 Elsevier Inc. All rights reserved.
C1 [McCoy, Brittany M.; Rickert, Martin E.; Class, Quetzal A.; D'Onofrio, Brian M.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
   [Larsson, Henrik; Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
RP D'Onofrio, BM (reprint author), Indiana Univ, Dept Psychol & Brain Sci, 1101 East 10th St, Bloomington, IN 47405 USA.
EM bmdonofr@indiana.edu
RI Maattanen, Laura/N-5424-2014
FU National Institute of Child Health and Human Development [HD061817];
   National Institute of Mental Health [MH094011]; Swedish council for
   working life and social research; Swedish Research Council (Medicine);
   Swedish Society of Medicine
FX The study was supported by grants from the National Institute of Child
   Health and Human Development (HD061817), National Institute of Mental
   Health (MH094011), the Swedish council for working life and social
   research, the Swedish Research Council (Medicine), and the Swedish
   Society of Medicine.
CR Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
   Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bennedsen BE, 1998, SCHIZOPHR RES, V33, P1, DOI 10.1016/S0920-9964(98)00065-6
   Visser S. N., 2010, Morbidity and Mortality Weekly Report, V59, P1439
   Centre for Epidemiology, 2003, SWED MED BRIT REG SU
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Daniels JL, 2008, PEDIATRICS, V121, pE1357, DOI 10.1542/peds.2007-2296
   D'Onofrio BM, JAMA PSYCHI IN PRESS
   de Bie HMA, 2010, HORM RES PAEDIAT, V73, P6, DOI 10.1159/000271911
   D'Onofrio BM, 2013, JAMA PSYCHIAT, V70, P1231, DOI 10.1001/jamapsychiatry.2013.2107
   Ekholm B, 2005, NORD J PSYCHIAT, V59, P457, DOI 10.1080/08039480500360906
   Fazel S, 2006, AM J PSYCHIAT, V163, P1397, DOI 10.1176/appi.ajp.163.8.1397
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Guinchat V, 2012, ACTA OBSTET GYN SCAN, V91, P287, DOI 10.1111/j.1600-0412.2011.01325.x
   Hack M, 2009, J DEV BEHAV PEDIATR, V30, P122, DOI 10.1097/DBP.0b013e31819e6a16
   Halmoy A, 2012, BIOL PSYCHIAT, V71, P474, DOI 10.1016/j.biopsych.2011.11.013
   Idring S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041280
   Killeya-Jones LA, 2007, J SCHOOL PSYCHOL, V45, P549, DOI 10.1016/j.jsp.2007.04.002
   Larsson H, 2013, BRIT J PSYCHIAT, V203, P103, DOI 10.1192/bjp.bp.112.120808
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lee HC, 2010, J AFFECT DISORDERS, V121, P100, DOI 10.1016/j.jad.2009.05.019
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
   Lindstrom K, 2011, PEDIATRICS, V127, P858, DOI 10.1542/peds.2010-1279
   MacCabe JH, 2007, BIPOLAR DISORD, V9, P305, DOI 10.1111/j.1399-5618.2007.00382.x
   Mathews T J, 2008, Natl Vital Stat Rep, V57, P1
   Moore GS, 2012, AM J OBSTET GYNECOL, V206, P314
   Moster D, 2008, NEW ENGL J MED, V359, P262, DOI 10.1056/NEJMoa0706475
   Nigg JT, 2007, J AM ACAD CHILD PSY, V46, P362, DOI 10.1097/01.chi.0000246054.76167.44
   Nilsson E, 2008, BRIT J PSYCHIAT, V193, P311, DOI [10.1192/bjp.bp.107.045146, 10.1192/bip.bp.107.045146]
   Nilsson E, 2002, SCHIZOPHR RES, V58, P221, DOI 10.1016/S0920-9964(01)00370-X
   Pelham WE, 2007, J PEDIATR PSYCHOL, V32, P711, DOI 10.1093/jpepsy/jsm022
   Pettersson E, 2013, J CHILD PSYCHOL PSYC, V54, P1356, DOI 10.1111/jcpp.12113
   Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049
   Schlotz W, 2009, BRAIN BEHAV IMMUN, V23, P905, DOI 10.1016/j.bbi.2009.02.001
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Skranes J, 2009, EUR J PAEDIATR NEURO, V12, P273
   Smith GD, 2008, BASIC CLIN PHARMACOL, V102, P245, DOI 10.1111/j.1742-7843.2007.00191.x
   Statistics Sweden, 2006, MICR IN AGR, P6
   Sullivan PF, 2012, ARCH GEN PSYCHIAT, V69, P1099, DOI 10.1001/archgenpsychiatry.2012.730
   Sullivan PF, 2012, ARCH GEN PSYCHIAT, P1
   Theule J, 2013, J EMOT BEHAV DISORD, V21, P3, DOI 10.1177/1063426610387433
   Walhovd KB, 2012, P NATL ACAD SCI USA, V109, P20089, DOI 10.1073/pnas.1208180109
   Whitaker AH, 2011, ARCH GEN PSYCHIAT, V68, P742, DOI 10.1001/archgenpsychiatry.2011.62
   Whitehouse AJO, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023029
NR 47
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD SEP
PY 2014
VL 24
IS 9
BP 629
EP 634
DI 10.1016/j.annepidem.2014.05.010
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AN8OX
UT WOS:000340864600001
PM 25037304
ER

PT J
AU Yousafzai, AK
   Lynch, P
   Gladstone, M
AF Yousafzai, Aisha K.
   Lynch, Paul
   Gladstone, Melissa
TI Moving beyond prevalence studies: screening and interventions for
   children with disabilities in low-income and middle-income countries
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; AUTISM SPECTRUM DISORDER; KEY INFORMANT
   METHOD; CEREBRAL-PALSY; YOUNG-CHILDREN; CHILDHOOD DISABILITY; PARENTS
   CONCERNS; 10 QUESTIONS; INTELLECTUAL DISABILITIES; NEUROLOGICAL
   IMPAIRMENT
AB Research understanding the lives of children with disabilities in low-income and middle-income countries has predominantly focused on prevalence studies with little progress on evidence-based service development. At the same time, global attention in child health has shifted from child survival strategies to those that bring child survival and development together. This review examines whether intervention research can be better aligned with current theoretical constructs of disability and international guidelines that advocate for the realisation of rights for children with disabilities and inclusive early childhood development.
C1 [Yousafzai, Aisha K.] Aga Khan Univ, Dept Paediat & Child Hlth, Karachi 74800, Pakistan.
   [Lynch, Paul] Univ Birmingham, Sch Educ, Dept Inclus, Birmingham B15 2TT, W Midlands, England.
   [Gladstone, Melissa] Univ Liverpool, Dept Women & Childrens Hlth, Inst Translat Med, Liverpool L69 3BX, Merseyside, England.
RP Yousafzai, AK (reprint author), Aga Khan Univ, Dept Paediat & Child Hlth, Stadium Rd,POB 3500, Karachi 74800, Pakistan.
EM aisha.yousafzai@aku.edu
CR Abubakar A, 2012, INT J ENV RES PUB HE, V9, P3506, DOI 10.3390/ijerph9103506
   Adams MS, 2012, CHILD CARE HLTH DEV, V38, P878, DOI 10.1111/j.1365-2214.2011.01327.x
   al-Naquib N, 1999, J Med Liban, V47, P95
   Ambikile Joel Semel, 2012, Child Adolesc Psychiatry Ment Health, V6, P16, DOI 10.1186/1753-2000-6-16
   Azar M, 2010, J PEDIATR NURS, V25, P46, DOI 10.1016/j.pedn.2008.11.001
   Bellman M, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e8687
   Bilgin Hulya, 2010, J Child Adolesc Psychiatr Nurs, V23, P92, DOI 10.1111/j.1744-6171.2010.00228.x
   Bricker D., 1999, AGES STAGES QUESTION
   Carter JA, 2005, INT J LANG COMM DIS, V40, P385, DOI 10.1080/13682820500057301
   Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
   Dhar RL, 2009, SOC SCI J, V46, P738, DOI 10.1016/j.soscij.2009.05.009
   Douglas D, 2012, BRIT J VISUAL IMPAIR, V30, P6
   DURKIN MS, 1994, EPIDEMIOLOGY, V5, P283, DOI 10.1097/00001648-199405000-00005
   Engle PL, 2011, LANCET, V378, P1339, DOI 10.1016/S0140-6736(11)60889-1
   Ertem IO, 2008, PEDIATRICS, V121, pE581, DOI 10.1542/peds.2007-1771
   FRANKENBURG WK, 1992, PEDIATRICS, V89, P91
   Geere JL, 2012, CHILD CARE HLTH DEV, V39, P381, DOI DOI 10.1111/J.1365-2214.2012.01398.X
   Geisinger K, 2006, PSYCHOL ASSESSMENT, V6, P304
   Gladstone M, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000273
   GLASCOE FP, 1989, AM J DIS CHILD, V143, P955
   Glascoe FP, 1999, AMBULATORY CHILD HLT, V5, P197
   Glascoe FP, 2006, ARCH PEDIAT ADOL MED, V160, P20
   Glascoe FP, 2005, J PAEDIATR CHILD H, V41, P615, DOI 10.1111/j.1440-1754.2005.00733_7.x
   GLASCOE FP, 1990, PEDIATRICS, V86, P547
   GLASCOE FP, 1991, CLIN PEDIATR, V30, P8, DOI 10.1177/000992289103000101
   Glascoe FP, 1998, COLLABORATING PARENT
   Glascoe FP, 1991, CLIN PEDIATR, V30, P12
   Glascoe FP, 2005, J PAEDIAT CHILD H, V41, P16
   Glascoe FP, 2003, CLIN PEDIATR, V42, P133, DOI 10.1177/000992280304200206
   Glascoe FP, 2006, ARCH PEDIAT ADOL MED, V160, P220, DOI 10.1001/archpedi.160.2.220-a
   GLASCOE FP, 1992, PEDIATRICS, V89, P1221
   Glascoe FP, 1997, PARENTS EVALUATION D
   Gona JK, 2014, CHILD CARE HLTH DEV, V40, P29, DOI 10.1111/cch.12031
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Groce NE, 2009, LANCET, V374, P1800, DOI 10.1016/S0140-6736(09)61909-7
   Hartley S, 2009, LANCET, V374, P1803, DOI 10.1016/S0140-6736(09)62036-5
   Holding PA, 2004, J INT NEUROPSYCH SOC, V10, P246, DOI 10.1017/S1355617704102166
   John A, 2012, J APPL RES INTELLECT, V25, P372, DOI 10.1111/j.1468-3148.2011.00672.x
   Juneja M, 2012, INDIAN PEDIATR, V49, P457
   Juneja M, 2012, INDIAN J PEDIATR, V79, P1213, DOI 10.1007/s12098-011-0653-0
   Kelly A, 2012, J POLICY PRACT INTEL, V9, P195, DOI 10.1111/j.1741-1130.2012.00354.x
   Khan NZ, 2006, PEDIATRICS, V118, P280, DOI 10.1542/peds.2005-2014
   Khan NZ, 2013, CHILD CARE HLTH DEV, V39, P643, DOI 10.1111/j.1365-2214.2012.01393.x
   KUMAR R, 1991, Indian Journal of Pediatrics, V58, P239, DOI 10.1007/BF02751128
   Kvestad I, 2013, J NUTR, V12, P1, DOI DOI 10.1186/1475-2891-12-1
   Lansdown RG, 1996, B WORLD HEALTH ORGAN, V74, P283
   Lim H. C., 1996, Annals Academy of Medicine Singapore, V25, P200
   Mackey S, 2012, J TROP PEDIATRICS, V58, P269, DOI 10.1093/tropej/fmr094
   Mactaggart I, 2013, KEY INFORM CHILD DIS
   Maloni PK, 2010, DISABIL REHABIL, V32, P845, DOI 10.3109/09638280903326063
   Maulik PK, 2007, PEDIATRICS, V120, pS1, DOI 10.1542/peds.2007-00438
   McConachie H, 2000, J PEDIATR-US, V137, P769, DOI 10.1067/mpd.2000.110135
   McConachie H, 2001, CHILD CARE HLTH DEV, V27, P1, DOI 10.1046/j.1365-2214.2001.00207.x
   McConkey R, 2013, DISABIL REHABIL, V35, P775, DOI 10.3109/09638288.2012.707744
   MILLER V, 1984, J PEDIATR-US, V104, P481, DOI 10.1016/S0022-3476(84)81122-1
   Mirza I, 2009, J INTELL DISABIL RES, V53, P559, DOI 10.1111/j.1365-2788.2009.01176.x
   Mobarak R, 2000, J PEDIATR PSYCHOL, V25, P427, DOI 10.1093/jpepsy/25.6.427
   Muhit MA, 2007, BRIT J OPHTHALMOL, V91, P995, DOI 10.1136/bjo.2006.108027
   Mung'ala-Odera V, 2004, NEUROEPIDEMIOLOGY, V23, P67, DOI 10.1159/000073977
   Mung'ala-Odera V, 2007, CHILD CARE HLTH DEV, V33, P249, DOI 10.1111/j.1365-2214.2006.00714.x
   Nations United, 2006, CONV RIGHTS PERS DIS
   Nussbaum M., 2000, WOMEN HUMAN DEV CAPA
   Officer A, 2009, LANCET, V374, P1795, DOI 10.1016/S0140-6736(09)61527-0
   Park SY, 2010, J APPL RES INTELLECT, V23, P38, DOI 10.1111/j.1468-3148.2009.00550.x
   Prado EL, 2010, BRIT J EDUC PSYCHOL, V80, P31, DOI 10.1348/000709909X470483
   Roberts J, 2011, RES AUTISM SPECT DIS, V5, P1553, DOI 10.1016/j.rasd.2011.03.001
   Samadi SA, 2013, AUTISM, V17, P27, DOI 10.1177/1362361311435156
   Samadi SA, 2012, EARLY CHILD DEV CARE, V182, P1439, DOI DOI 10.1080/03004430.2011.616931
   Sen A, 1992, INEQUALITY REEXAMINE
   Sen R, 2005, INT J DISABIL DEV ED, V52, P275, DOI DOI 10.1080/10349120500348623
   Shakespeare T, 2006, DISABILITY RIGHTS WR
   SHAPIRA Y, 1983, ISRAEL J MED SCI, V19, P246
   Shin JY, 2009, J INTELL DISABIL RES, V53, P39
   SHONKOFF JP, 1987, PEDIATRICS, V80, P650
   Simeonsson RJ, 2000, J CLIN EPIDEMIOL, V53, P113, DOI 10.1016/S0895-4356(99)00133-X
   SOLOMONS HC, 1982, INT J REHABIL RES, V5, P179, DOI 10.1097/00004356-198206000-00004
   Thuy NTM, 2013, GLOBAL HLTH ACTION, V6, P18888
   UNICEF, 2013, STAT WORLDS CHILDR 2
   Washington Group on Disability Statistics, 2009, UND INT DIS MEAS US
   World Health Organisation, 2001, INT CLASS FUNCT DIS
   World Health Organization United Nations Educational Scientific and Cultural Organization International Labour Organization International Disability and Development Consortium, 2010, COMM BAS REH CBR GUI
   Wu LA, 2012, CHILD CARE HLTH DEV, V38, P332, DOI 10.1111/j.1365-2214.2011.01221.x
   Yousafzai AK, 2011, DISABIL REHABIL, V33, P989, DOI 10.3109/09638288.2010.520811
   ZAMAN SS, 1990, INT J EPIDEMIOL, V19, P613, DOI 10.1093/ije/19.3.613
NR 84
TC 3
Z9 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD SEP
PY 2014
VL 99
IS 9
BP 840
EP 848
DI 10.1136/archdischild-2012-302066
PG 9
WC Pediatrics
SC Pediatrics
GA AN8BN
UT WOS:000340826300012
PM 24647995
ER

PT J
AU Saloviita, T
   Leppanen, M
   Ojalammi, U
AF Saloviita, Timo
   Leppanen, Marjatta
   Ojalammi, Ulla
TI Authorship in Facilitated Communication: An Analysis of 11 Cases
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Autism; Facilitated communication; Intellectual disabilities;
   Augmentative and alternative communication
ID AUTISM; GRAMMAR; LEXICON; AAC
AB We studied the authorship of messages produced through facilitated communication (FC) for all users of FC in two comprehensive schools in a small city in Finland. The participants were 11 children with intellectual disabilities, including autism, all having used FC from 1 - 3 years. The test conditions involved open and blind information- passing tasks in which the participants were directed to write down the contents of written or pictorial stimuli. The results failed to validate FC as a method of communication for any participant or facilitator. An analysis of the messages produced under the FC condition revealed a large degree of facilitator infl uence on the content of the messages produced. Additionally, FC impaired the performance of the two participants who had previously demonstrated some independent writing skills.
C1 [Saloviita, Timo] Univ Jyvaskyla, Dept Teacher Educ, FIN-40014 Jyvaskyla, Finland.
   [Ojalammi, Ulla] Nuoliala Primary Sch, Tampere, Finland.
RP Saloviita, T (reprint author), Univ Jyvaskyla, Dept Teacher Educ, POB 35, FIN-40014 Jyvaskyla, Finland.
EM timo.saloviita@jyu.fi
CR Bernardi L., 2011, COMPREHENSIVE BOOK A, P413
   Bernardi L, 2011, AUGMENT ALTERN COMM, V27, P183, DOI 10.3109/07434618.2011.610353
   Biklen D., 2005, AUTISM MYTH PERSON A
   Biklen D, 1991, DISABILITY HANDICAP, V6, P161, DOI 10.1080/02674649166780231
   Biklen D., 1993, FACILITATED COMMUNIC, V2, P10
   Biklen D., 1997, CONTESTED WORDS CONT, P5
   Biklen D., FACTS FACILITATED CO
   Boynton J., 2012, EVIDENCE BASED COMMU, V6, P3
   Burgess CA, 1998, PSYCHOL SCI, V9, P71, DOI 10.1111/1467-9280.00013
   Crossley R., 1994, FACILITATED COMMUNIC
   CUMMINS RA, 1992, HARVARD EDUC REV, V62, P228
   EBERLIN M, 1993, J AUTISM DEV DISORD, V23, P507, DOI 10.1007/BF01046053
   Emerson A, 2001, INT J LANG COMM DIS, V36, P98
   Grayson A, 2012, AUTISM, V16, P75, DOI 10.1177/1362361310393260
   ICI, 2010, BAS FAC COMM SUPP TY
   ICI, 2012, BEST PRACT COMM SUPP
   Jacobson J. W, 2005, CONTROVERSIAL THERAP
   Jacobson J. W., 2005, CONTROVERSIAL THERAP, P63
   JACOBSON JW, 1995, AM PSYCHOL, V50, P750, DOI 10.1037//0003-066X.50.9.750
   Kerola K., 2009, AUSTISMIN KIRJO JA K
   Maatta K., 2011, PSYCHOL LANGUAGE COM, V15, P1
   Mirenda P, 2008, AUGMENT ALTERN COMM, V24, P220, DOI 10.1080/08990220802388263
   MONTEE BB, 1995, J APPL BEHAV ANAL, V28, P189, DOI 10.1901/jaba.1995.28-189
   Mostert MP, 2001, J AUTISM DEV DISORD, V31, P287, DOI 10.1023/A:1010795219886
   Mostert MP, 2010, EXCEPTIONALITY, V18, P31, DOI 10.1080/09362830903462524
   National Advisory Board on Research Ethics, 2009, ETH PRINC RES HUM SO
   Niemi J, 2002, MENT RETARD, V40, P347, DOI 10.1352/0047-6765(2002)040<0347:GALIFC>2.0.CO;2
   Perini S., 2010, PSICOTERAPIA COGNITI, V16, P103
   REGAL RA, 1994, J AUTISM DEV DISORD, V24, P345, DOI 10.1007/BF02172232
   Saloviita T, 2003, MENT RETARD, V41, P374, DOI 10.1352/0047-6765(2003)41<374:AIFCAR>2.0.CO;2
   Scopesi A., 2003, RIV PSICOLINGUISTICA, V2-3, P83
   Simpson R., 1995, J SPEC EDUC, V28, P242
   Tuzzi A, 2009, INTELLECT DEV DISAB, V47, P373, DOI 10.1352/1934-9556-47.5.373
   Wegner DM, 2003, J PERS SOC PSYCHOL, V85, P5, DOI 10.1037/0022-3514.85.1.5
   WHEELER DL, 1993, MENT RETARD, V31, P49
   Zanobini M., 2001, PSICOLOGIA CLIN SVIL, V3, P395
NR 36
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
EI 1477-3848
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2014
VL 30
IS 3
BP 213
EP 225
DI 10.3109/07434618.2014.927529
PG 13
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA AO4JE
UT WOS:000341302500003
PM 24946681
ER

PT J
AU Langen, M
   Bos, D
   Noordermeer, DS
   Nederveen, H
   van Engeland, H
   Durston, S
AF Langen, Marieke
   Bos, Dienke
   Noordermeer, D. S.
   Nederveen, Hilde
   van Engeland, Herman
   Durston, Sarah
TI Changes in the Development of Striatum Are Involved in Repetitive
   Behavior in Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism; brain development; corticostriatal circuitry; insistence on
   sameness; repetitive behavior; striatum
ID SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; INHIBITORY CONTROL; BRAIN
   OVERGROWTH; CAUDATE-NUCLEUS; BASAL GANGLIA; DAT1 GENOTYPE; VOLUME;
   CHILDREN; TRAJECTORIES
AB Background: Repetitive behavior is a core feature of autism and has been linked to differences in striatum. In addition, the brain changes associated with autism appear to vary with age. However, most studies investigating striatal differences in autism are cross-sectional, limiting inferences on development. In this study, we set out to 1) investigate striatal development in autism, using a longitudinal design; and 2) examine the relationship between striatal development and repetitive behavior.
   Methods: We acquired longitudinal structural magnetic resonance imaging scans from 86 individuals (49 children with autism, 37 matched control subjects). Each individual was scanned twice, with a mean scan interval time of 2.4 years. Mean age was 9.9 years at time 1 and 12.3 years at time 2. Striatal structures were traced manually with high reliability. Multivariate analyses of variance were used to investigate differences in brain development between diagnostic groups. To examine the relationship with behavior, correlations between changes in brain volumes and clinical measures were calculated.
   Results: Our results showed an increase in the growth rate of striatal structures for individuals with autism compared with control subjects. The effect was specific to caudate nucleus, where growth rate was doubled. Second, faster striatal growth was correlated with more severe repetitive behavior (insistence on sameness) at the preschool age.
   Conclusions: This longitudinal study of brain development in autism confirms the involvement of striatum in repetitive behavior. Furthermore, it underscores the significance of brain development in autism, as the severity of repetitive behavior was related to striatal growth, rather than volume per se.
C1 [Langen, Marieke; Bos, Dienke; Noordermeer, D. S.; Nederveen, Hilde; van Engeland, Herman; Durston, Sarah] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, NICHE Lab, Utrecht, Netherlands.
RP Langen, M (reprint author), Univ Med Ctr Utrecht, Julius Ctr, HP STR 6,131 Heidelber Glaan 100, NL-3584 CX Utrecht, Netherlands.
EM m.langen@umcutrecht.nl
CR Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
   ALEXANDER GE, 1990, TRENDS NEUROSCI, V13, P266, DOI 10.1016/0166-2236(90)90107-L
   ALEXANDER GE, 1986, ANNU REV NEUROSCI, V9, P357, DOI 10.1146/annurev.ne.09.030186.002041
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4
   Aylward EH, 2002, NEUROLOGY, V59, P175
   Bartres-Faz D, 2002, NEUROREPORT, V13, P1121, DOI 10.1097/00001756-200207020-00010
   Braun NN, 2007, NEUROREPORT, V18, P1841
   Casanova MF, 2002, NEUROLOGY, V58, P428
   Catani M, 2012, CORTEX, V48, P273, DOI 10.1016/j.cortex.2011.12.001
   COSTELLO EJ, 1985, J ABNORM CHILD PSYCH, V13, P579, DOI 10.1007/BF00923143
   Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947
   Durston S, 2009, J AM ACAD CHILD PSY, V48, P206, DOI 10.1097/CHI.0b013e3181930673
   Durston S, 2005, MOL PSYCHIATR, V10, P678, DOI 10.1038/sj.mp.4001649
   Durston S, 2006, DEVELOPMENTAL SCI, V9, P1, DOI 10.1111/j.1467-7687.2005.00454.x
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
   Giedd JN, 2010, NEURON, V67, P728, DOI 10.1016/j.neuron.2010.08.040
   Giedd Jay N, 2008, Novartis Found Symp, V289, P101
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Hardan AY, 2009, BIOL PSYCHIAT, V66, P320, DOI 10.1016/j.biopsych.2009.04.024
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Hickie IB, 2007, J AFFECT DISORDERS, V98, P137, DOI 10.1016/j.jad.2006.07.010
   Honey E, 2006, J AUTISM DEV DISORD, V38, P1439
   Hu VW, 2009, AUTISM RES, V2, P67, DOI 10.1002/aur.72
   Kana RK, 2011, PHYS LIFE REV, V8, P410, DOI 10.1016/j.plrev.2011.10.001
   Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
   Kort W., 2005, WECHSLER INTELLIGENC
   Kremen WS, 2010, NEUROIMAGE, V49, P1213, DOI 10.1016/j.neuroimage.2009.09.043
   Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
   Langen M, 2011, NEUROSCI BIOBEHAV R, V35, P356, DOI 10.1016/j.neubiorev.2010.02.005
   Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   Lenroot RK, 2007, NEUROIMAGE, V36, P1065, DOI 10.1016/j.neuroimage.2007.03.053
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mosconi MW, 2009, PSYCHOL MED, V39, P1559, DOI 10.1017/S0033291708004984
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Munson J, 2006, ARCH GEN PSYCHIAT, V63, P686, DOI 10.1001/archpsyc.63.6.686
   Murphy GH, 2005, J AUTISM DEV DISORD, V35, P405, DOI 10.1007/s10803-005-5030-2
   Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6
   Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
   Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
   Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
   Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846
   Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008
   Shook D, 2011, AM J MED GENET B, V156B, P28, DOI 10.1002/ajmg.b.31132
   Soke GN, 2011, AUTISM, V15, P545, DOI 10.1177/1362361309358332
   Stein JL, 2011, MOL PSYCHIATR, V16, P927, DOI 10.1038/mp.2011.32
   Stinissen J, 1970, BEWERKING WECHSLER A
   Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x
   Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099
   Van Haasen P., 1986, WECHSLER INTELLIGENC
   Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757
   Wallace GL, 2006, J CHILD PSYCHOL PSYC, V47, P987, DOI 10.1111/j.1469-7610.2006.01676.x
   Wechsler D, 2000, WECHSLER ADULT INTEL, V3rd
NR 60
TC 5
Z9 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 1
PY 2014
VL 76
IS 5
BP 405
EP 411
DI 10.1016/j.biopsych.2013.08.013
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AN8WQ
UT WOS:000340886800011
PM 24090791
ER

PT J
AU Solomon, M
   Yoon, JH
   Ragland, JD
   Niendam, TA
   Lesh, TA
   Fairbrother, W
   Carter, CS
AF Solomon, Marjorie
   Yoon, Jong H.
   Ragland, J. Daniel
   Niendam, Tara A.
   Lesh, Tyler A.
   Fairbrother, Wonja
   Carter, Cameron S.
TI The Development of the Neural Substrates of Cognitive Control in
   Adolescents with Autism Spectrum Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Adolescence; autism spectrum disorders; cognitive control; development;
   fMRI; response inhibition
ID HIGH-FUNCTIONING AUTISM; ANTERIOR CINGULATE CORTEX;
   ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; WORKING-MEMORY; EXECUTIVE
   FUNCTION; RESPONSE-INHIBITION; CONNECTIVITY MRI; CORPUS-CALLOSUM;
   CONTROL NETWORK; MOTOR CONTROL
AB Background: Autism spectrum disorders (ASDs) involve impairments in cognitive control. In typical development (TYP), neural systems underlying cognitive control undergo substantial maturation during adolescence. Development is delayed in adolescents with ASD. Little is known about the neural substrates of this delay.
   Methods: We used event-related functional magnetic resonance imaging and a cognitive control task involving overcoming a prepotent response tendency to examine the development of cognitive control in young (ages 12-15; n = 13 with ASD and n = 13 with TYP) and older (ages 16-18; n = 14 with ASD and n = 14 with TYP) adolescents with whole-brain voxelwise univariate and task-related functional connectivity analyses.
   Results: Older ASD and TYP showed reduced activation in sensory and premotor areas relative to younger ones. The older ASD group showed reduced left parietal activation relative to TYP. Functional connectivity analyses showed a significant age by group interaction with the older ASD group exhibiting increased functional connectivity strength between the ventrolateral prefrontal cortex and the anterior cingulate cortex, bilaterally. This functional connectivity strength was related to task performance in ASD, whereas that between dorsolateral prefrontal cortex and parietal cortex (Brodmann areas 9 and 40) was related to task performance in TYP.
   Conclusions: Adolescents with ASD rely more on reactive cognitive control, involving last-minute conflict detection and control implementation by the anterior cingulate cortex and ventrolateral prefrontal cortex, versus proactive cognitive control requiring processing by dorsolateral prefrontal cortex and parietal cortex. Findings await replication in larger longitudinal studies that examine their functional consequences and amenability to intervention.
C1 [Solomon, Marjorie; Yoon, Jong H.; Ragland, J. Daniel; Niendam, Tara A.; Lesh, Tyler A.; Fairbrother, Wonja; Carter, Cameron S.] Univ Calif, Dept Psychiat & Behav Sci, Davis, CA USA.
   [Solomon, Marjorie; Fairbrother, Wonja] MIND Inst, Sacramento, CA USA.
   [Solomon, Marjorie; Yoon, Jong H.; Ragland, J. Daniel; Niendam, Tara A.; Lesh, Tyler A.; Carter, Cameron S.] Univ Calif Davis, Imaging Res Ctr, Sacramento, CA 95817 USA.
RP Solomon, M (reprint author), UC Davis Hlth Syst, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM marjorie.solomon@ucdmc.ucdavis.edu
FU National Institute of Mental Health [1-K-08 MH074967-01, 2R01
   MH059883-05A1, 1R24MH081807, K23MH087708, R01MH084895, K-08]; Building
   Interdisciplinary Research Careers in Women's Health Award - National
   Institute of Child Health and Human Development, Office of Research on
   Women's Health, Office of Dietary Supplements [K12 HD051958]; National
   Institute of Aging; National Alliance for Research on Schizophrenia and
   Depression (Atherton Foundation); GlaxoSmithKline
FX This work was supported by a K-08 Award from the National Institute of
   Mental Health (1-K-08 MH074967-01); a Building Interdisciplinary
   Research Careers in Women's Health Award (K12 HD051958) funded by the
   National Institute of Child Health and Human Development, Office of
   Research on Women's Health, Office of Dietary Supplements, and the
   National Institute of Aging; and a Pilot Award from the National
   Alliance for Research on Schizophrenia and Depression (Atherton
   Foundation) to Marjorie Solomon. During the time of the study, Dr.
   Carter was supported by the National Institute of Mental Health (2R01
   MH059883-05A1) and (1R24MH081807). Dr. Niendam was supported by the
   National Institute of Mental Health (K23MH087708). Dr. Ragland was
   supported by the National Institute of Mental Health (R01MH084895,
   Ragland, Principal Investigator).Dr. Carter reports having been a
   consultant for Pfizer, Merck, Lilly, and Servier. He also has received
   funding from GlaxoSmithKline. Drs. Solomon, Yoon, Ragland, Niendam, and
   Lesh and Ms. Fair-brother report no biomedical financial interests or
   potential conflicts of interest.
CR Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
   American Psychiatric Association, 2013, DSM 5
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Andrews-Hanna JR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021598
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
   Aylward EH, 2002, NEUROLOGY, V59, P175
   Barber AD, 2005, CEREB CORTEX, V15, P899, DOI 10.1093/cercor/bhh189
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Berl MM, 2006, NEUROIMAGE, V30, P679, DOI 10.1016/j.neuroimage.2005.10.007
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Botvinick MM, 2004, TRENDS COGN SCI, V8, P539, DOI 10.1016/j.tics.2004.10.003
   Braver T. S., 2002, PRINCIPLES FRONTAL L, P428, DOI DOI 10.1093/ACPROF:OSO/9780195134971.003.0027
   Braver TS, 2012, TRENDS COGN SCI, V16, P106, DOI 10.1016/j.tics.2011.12.010
   Brett M., 2002, NEUROIMAGE, V16, P2
   Brown TT, 2005, CEREB CORTEX, V15, P275, DOI 10.1093/cercor/bhh129
   Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
   Bunge SA, 2007, CURR OPIN NEUROBIOL, V17, P243, DOI 10.1016/j.conb.2007.02.005
   Carter CS, 1998, SCIENCE, V280, P747, DOI 10.1126/science.280.5364.747
   Casey BJ, 2005, CURR OPIN NEUROBIOL, V15, P239, DOI 10.1016/j.conb.2005.03.012
   Chung MK, 2004, NEUROIMAGE, V23, P242, DOI 10.1016/j.neuroimage.2004.04.037
   Conners CK, 1998, J ABNORM CHILD PSYCH, V26, P257, DOI 10.1023/A:1022602400621
   Cramer SC, 2011, BRAIN, V134, P1591, DOI 10.1093/brain/awr039
   Crone EA, 2006, P NATL ACAD SCI USA, V103, P9315, DOI 10.1073/pnas.0510088103
   Crone Eveline A, 2011, Dev Cogn Neurosci, V1, P101, DOI 10.1016/j.dcn.2010.12.001
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   D'Esposito M, 2007, PHILOS T R SOC B, V362, P761, DOI 10.1098/rstb.2007.2086
   Dosenbach NUF, 2010, SCIENCE, V329, P1358, DOI 10.1126/science.1194144
   Dulcan MK, 2010, DULCANS TXB CHILD AD
   Durston S, 2006, NEUROPSYCHOLOGIA, V44, P2149, DOI 10.1016/j.neuropsychologia.2005.10.010
   Durston S, 2006, DEVELOPMENTAL SCI, V9, P1, DOI 10.1111/j.1467-7687.2005.00454.x
   Fair DA, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000381
   Fair DA, 2008, P NATL ACAD SCI USA, V105, P4028, DOI 10.1073/pnas.0800376105
   Fair DA, 2007, P NATL ACAD SCI USA, V104, P13507, DOI 10.1073/pnas.0705843104
   Finn AS, 2010, J NEUROSCI, V30, P11062, DOI 10.1523/JNEUROSCI.6266-09.2010
   Friston KJ, 1996, NEUROIMAGE, V4, P223, DOI 10.1006/nimg.1996.0074
   Giedd JN, 2008, J ADOLESCENT HEALTH, V42, P335, DOI 10.1016/j.jadohealth.2008.01.007
   Gillespie-Lynch K, 2012, J AUTISM DEV DISORD, V42, P161, DOI 10.1007/s10803-011-1222-0
   Goldberg MC, 2011, DEV COGN NEUROS-NETH, V1, P47, DOI 10.1016/j.dcn.2010.07.002
   Gray JR, 2004, NAT REV NEUROSCI, V5, P471, DOI 10.1038/nrn1405
   Greicius MD, 2009, CEREB CORTEX, V19, P72, DOI 10.1093/cercor/bhn059
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hardan AY, 2000, NEUROLOGY, V55, P1033
   Honey GD, 2003, BRAIN, V126, P1767, DOI 10.1093/brain/awg184
   Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Jolles DD, 2011, DEVELOPMENTAL SCI, V14, P713, DOI 10.1111/j.1467-7687.2010.01016.x
   Jolles DD, 2011, CEREB CORTEX, V21, P385, DOI 10.1093/cercor/bhq104
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kaldy Z, 2011, DEVELOPMENTAL SCI, V14, P980, DOI 10.1111/j.1467-7687.2011.01053.x
   Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
   Katic R, 2012, COLLEGIUM ANTROPOL, V36, P563
   Kelly A M Clare, 2009, Cereb Cortex, V19, P640, DOI 10.1093/cercor/bhn117
   Kenet T, 2012, NEUROIMAGE, V61, P1226, DOI 10.1016/j.neuroimage.2012.03.010
   Killikelly C, 2013, DEV COGN NEUROS-NETH, V3, P33, DOI 10.1016/j.dcn.2012.08.002
   Ladouceur CD, 2007, DEVELOPMENTAL SCI, V10, P874, DOI 10.1111/j.1467-7687.2007.00639.x
   Ladouceur CD, 2004, ANN NY ACAD SCI, V1021, P329, DOI 10.1196/annals.1308.040
   Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
   Larson MJ, 2012, J CHILD PSYCHOL PSYC, V53, P440, DOI 10.1111/j.1469-7610.2011.02498.x
   Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
   Lenneberg E., 1967, BIOL FDN LANGUAGE
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luciana M, 2005, CHILD DEV, V76, P697, DOI 10.1111/j.1467-8624.2005.00872.x
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   MacDonald AW, 2000, SCIENCE, V288, P1835, DOI 10.1126/science.288.5472.1835
   Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x
   Maldjian JA, 2003, NEUROIMAGE, V19, P1233, DOI 10.1016/S1053-8119(03)00169-1
   Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
   Miller EK, 2001, ANNU REV NEUROSCI, V24, P167, DOI 10.1146/annurev.neuro.24.1.167
   Mostofsky SH, 2007, BRAIN, V130, P2117, DOI 10.1093/brain/awm129
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Muller RA, 1998, J CHILD NEUROL, V13, P550
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Murphy K, 2009, NEUROIMAGE, V44, P893, DOI 10.1016/j.neuroimage.2008.09.036
   Natick M, 2000, MATLAB
   Nebel MB, 2014, HUM BRAIN MAPP, V35, P567, DOI 10.1002/hbm.22188
   Niendam TA, 2012, COGN AFFECT BEHAV NE, V12, P241, DOI 10.3758/s13415-011-0083-5
   Nyden A, 2000, EUR CHILD ADOLES PSY, V9, P180
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   Ozonoff S, 2000, ASPERGER SYNDROME, P72
   OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027
   Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
   Piven J, 1997, AM J PSYCHIAT, V154, P1051
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Rissman J, 2004, NEUROIMAGE, V23, P752, DOI 10.1016/j.neuroimage.2004.06.035
   Rosano C, 2005, NEUROIMAGE, V28, P881, DOI 10.1016/j.neuroimage.2005.05.059
   Rubia K, 2012, EUR CHILD ADOLESC PS
   Rubia K, 2007, HUM BRAIN MAPP, V28, P1163, DOI 10.1002/hbm.20347
   Rutter M., 2003, SCQ SOCIAL COMMUNICA
   Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
   Snitz BE, 2005, AM J PSYCHIAT, V162, P2322, DOI 10.1176/appi.ajp.162.12.2322
   Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
   Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001
   Somsen RJM, 2007, DEVELOPMENTAL SCI, V10, P664, DOI 10.1111/j.1467-7687.2007.00613.x
   Stano JF, 2004, REHABILITATION COUNS, V48, P56, DOI DOI 10.1177/00343552040480
   Supekar K, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002374
   Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099
   Vaidya CJ, 2011, DEVELOPMENTAL SCI, V14, P911, DOI 10.1111/j.1467-7687.2011.01041.x
   Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wellcome Department of Cognitive Neurology, 2009, SPM 8
   Yerys BE, 2012, J AUTISM DEV DISORD, V42, P2013, DOI 10.1007/s10803-012-1443-x
   Zikopoulos B, 2010, J NEUROSCI, V30, P14595, DOI 10.1523/JNEUROSCI.2257-10.2010
NR 106
TC 4
Z9 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 1
PY 2014
VL 76
IS 5
BP 412
EP 421
DI 10.1016/j.biopsych.2013.08.036
PG 10
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AN8WQ
UT WOS:000340886800012
PM 24209777
ER

PT J
AU Nuske, HJ
   Vivanti, G
   Hudry, K
   Dissanayake, C
AF Nuske, Heather J.
   Vivanti, Giacomo
   Hudry, Kristelle
   Dissanayake, Cheryl
TI Pupillometry reveals reduced unconscious emotional reactivity in autism
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Autism; Emotion; Pupil dilation; Unconscious; Subliminal; Implicit;
   Backwards masking; Eye tracking; Autonomic nervous system; Physiological
   responding; Pupillometry
ID FACIAL EXPRESSIONS; SPECTRUM DISORDERS; BACKWARD-MASKING;
   YOUNG-CHILDREN; CONSCIOUS PERCEPTION; ASPERGER-SYNDROME; NEURAL
   CIRCUITRY; HUMAN AMYGDALA; PUPIL SIZE; FACE
AB Recent theoretical conceptualisations have suggested that emotion processing impairments in autism stem from disruption to the sub-cortical, rapid emotion-processing system. We argue that a clear way to ascertain whether this system is affected in autism is by measuring unconscious emotional reactivity. Using backwards masking, we presented fearful expressions non-consciously (subliminally) as well as consciously (supraliminally), and measured pupillary responses as an index of emotional reactivity in 19 children with autism and 19 typically developing children, aged 2-5 years. The pupillary responses of the children with autism revealed reduced unconscious emotional reactivity, with no group differences on consciously presented emotion. Together, these results indicate a hyporesponsiveness to non-consciously presented emotion suggesting a fundamental difference in emotion processing in autism, which requires consciousness and more time. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Nuske, Heather J.; Vivanti, Giacomo; Hudry, Kristelle; Dissanayake, Cheryl] La Trobe Univ, Sch Psychol, Olga Tennison Autism Res Ctr, Melbourne, Vic 3086, Australia.
   [Vivanti, Giacomo] La Trobe Univ, Victorian Autism Specif Early Learning & Care Ctr, Bundoora, Vic 3086, Australia.
RP Dissanayake, C (reprint author), La Trobe Univ, Sch Psychol, Olga Tennison Autism Res Ctr, Melbourne, Vic 3086, Australia.
EM h.nuske@latrobe.edu.au; g.vivanti@latrobe.edu.au;
   k.hudry@latrobe.edu.au; c.dissanayake@latrobe.edu.au
CR ADOLPHS R, 1994, NATURE, V372, P669, DOI 10.1038/372669a0
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Akechi H, 2009, CHILD DEV, V80, P1134, DOI 10.1111/j.1467-8624.2009.01321.x
   APA, 2013, DSM 5 DIAGN STAT MAN
   APPLEGATE CD, 1983, PHYSIOL BEHAV, V31, P353, DOI 10.1016/0031-9384(83)90201-9
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Batty M, 2011, J EXP CHILD PSYCHOL, V109, P430, DOI 10.1016/j.jecp.2011.02.001
   Berridge KC, 2003, COGNITION EMOTION, V17, P181, DOI 10.1080/02699930244000273
   Bornemann B, 2012, INT J PSYCHOPHYSIOL, V85, P116, DOI 10.1016/j.ijpsycho.2011.04.007
   Bradley MM, 2008, PSYCHOPHYSIOLOGY, V45, P602, DOI 10.1111/j.1469-8986.2008.00654.x
   Chau M., 2005, TECHNICAL REPORT
   Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Daly E. M., 2012, CONTEXT, V69, P1
   Damasio Antonio, 1999, FEELING WHAT HAPPENS
   Dannlowski U, 2007, PSYCHIAT RES-NEUROIM, V154, P13, DOI 10.1016/j.pscychresns.2006.05.005
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x
   De Cesarei A, 2009, NEUROREPORT, V20, P1439, DOI 10.1097/WNR.0b013e3283317d3e
   Deruelle C, 2008, BRAIN COGNITION, V66, P115, DOI 10.1016/j.bandc.2007.06.001
   Dimberg U, 1996, MOTIV EMOTION, V20, P149, DOI 10.1007/BF02253869
   Dimberg U, 2000, PSYCHOL SCI, V11, P86, DOI 10.1111/1467-9280.00221
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Ekman P., 1975, PICTURES FACIAL AFFE
   EKMAN P, 1983, SCIENCE, V221, P1208, DOI 10.1126/science.6612338
   ESTEVES F, 1993, SCAND J PSYCHOL, V34, P1, DOI 10.1111/j.1467-9450.1993.tb01096.x
   ESTEVES F, 1994, COGNITION EMOTION, V8, P393, DOI 10.1080/02699939408408949
   Farzin F, 2009, J AUTISM DEV DISORD, V39, P946, DOI 10.1007/s10803-009-0744-1
   Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
   Gross TF, 2008, J AUTISM DEV DISORD, V38, P297, DOI 10.1007/s10803-007-0391-3
   Hadjikhani N, 2009, SOC COGN AFFECT NEUR, V4, P70, DOI 10.1093/scan/nsn038
   Hall GBC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010804
   Hall GBC, 2007, BRAIN COGNITION, V65, P100, DOI 10.1016/j.bandc.2007.01.010
   Hepach R, 2012, PSYCHOL SCI, V23, P967, DOI 10.1177/0956797612440571
   Hobson R. P., 1989, AUTISM NATURE DIAGNO
   HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
   Hubl D, 2003, NEUROLOGY, V61, P1232
   Janisse M.P., 1977, PUPILLOMETRY PSYCHOL
   Johnson MH, 2005, NAT REV NEUROSCI, V6, P766, DOI 10.1038/nrn1766
   Kamio Y, 2006, J AUTISM DEV DISORD, V36, P155, DOI 10.1007/s10803-005-0056-z
   Keller K., 2011, J CHILD PSYCHOL PSYC, V53, P651, DOI DOI 10.1111/J.1469-7610.2011.02499.X
   Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037
   Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Koch C., 1990, SEMINARS NEUROSCIENC, V2
   Korpilahti P, 2007, J AUTISM DEV DISORD, V37, P1539, DOI 10.1007/s10803-006-0271-2
   Kuchinke L, 2011, NEUROPSYCHOLOGIA, V49, P331, DOI 10.1016/j.neuropsychologia.2010.12.026
   Laeng B, 2012, PERSPECT PSYCHOL SCI, V7, P18, DOI 10.1177/1745691611427305
   LeDoux J., 1996, EMOTIONAL BRAIN
   Levenson RW, 1996, MOTIV EMOTION, V20, P185, DOI 10.1007/BF02251886
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Loveland KA, 2008, PERCEPT MOTOR SKILL, V107, P557, DOI 10.2466/PMS.107.2.557-575
   Mack A., 1998, INATTENTIONAL BLINDN
   Malloch S., 2009, COMMUNICATIVE MUSICA
   Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
   Martineau J, 2011, J PSYCHIATR RES, V45, P1077, DOI 10.1016/j.jpsychires.2011.01.008
   McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
   Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085
   Morris JS, 1999, P NATL ACAD SCI USA, V96, P1680, DOI 10.1073/pnas.96.4.1680
   Morris JS, 1998, NATURE, V393, P467, DOI 10.1038/30976
   Morris JS, 2001, BRAIN, V124, P1241, DOI 10.1093/brain/124.6.1241
   Mullen E, 1995, MULLEN SCALES EARLY
   MURPHY ST, 1993, J PERS SOC PSYCHOL, V64, P723, DOI 10.1037//0022-3514.64.5.723
   Nakagawa S, 2004, BEHAV ECOL, V15, P1044, DOI 10.1093/beheco/arh107
   Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
   NIEDENTHAL PM, 1990, J EXP SOC PSYCHOL, V26, P505, DOI 10.1016/0022-1031(90)90053-O
   Nummenmaa L, 2012, P NATL ACAD SCI USA, V109, P9599, DOI 10.1073/pnas.1206095109
   Nuske HJ, 2014, J NEURODEV DISORD, V6, DOI 10.1186/1866-1955-6-14
   Nuske HJ, 2013, COGNITION EMOTION, V27, P1042, DOI 10.1080/02699931.2012.762900
   Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
   Ogai Masahiro, 2003, Neuroreport, V14, P559, DOI 10.1097/00001756-200303240-00006
   OHMAN A, 1994, J ABNORM PSYCHOL, V103, P231, DOI 10.1037/0021-843X.103.2.231
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
   Partala T, 2003, INT J HUM-COMPUT ST, V59, P185, DOI 10.1016/S1071-5819(03)00017-X
   Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
   Pegna AJ, 2008, INT J PSYCHOPHYSIOL, V70, P127, DOI 10.1016/j.ijpsycho.2008.08.007
   Pegna AJ, 2005, NAT NEUROSCI, V8, P24, DOI 10.1038/nn1364
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Perneger TV, 1998, BRIT MED J, V316, P1236
   Piggot J, 2004, J AM ACAD CHILD PSY, V43, P473, DOI 10.1097/01.chi.0000111363.94169.37
   RAAB DH, 1961, J ACOUST SOC AM, V33, P137, DOI 10.1121/1.1908600
   Rawlins W.K., 1992, FRIENDSHIP MATTERS C
   Rieffe C, 2010, PERS INDIV DIFFER, V49, P362, DOI 10.1016/j.paid.2010.03.046
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Rotteveel M, 2001, EMOTION, V1, P348, DOI 10.1037//1528-3542.1.4.348
   Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Senju A, 2012, BRAIN DEV
   Sepeta L, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-17
   Siegle G., 2013, CURRENT NEUROLOGY NE, V13
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Smith ML, 2012, CEREB CORTEX, V22, P1748, DOI 10.1093/cercor/bhr250
   Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027
   Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
   Stern D. N., 2010, FORMS VITALITY EXPLO
   Tamietto M, 2009, P NATL ACAD SCI USA, V106, P17661, DOI 10.1073/pnas.0908994106
   Tamietto M, 2010, NAT REV NEUROSCI, V11, P697, DOI 10.1038/nrn2889
   Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
   Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
   Tyszka J. M., 2013, CEREB CORTEX, V24, P1894
   Urry HL, 2006, J NEUROSCI, V26, P4415, DOI 10.1523/JNEUROSCI.3215-05.2006
   URSIN H, 1960, ELECTROEN CLIN NEURO, V12, P1, DOI 10.1016/0013-4694(60)90058-4
   Vivanti G, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00354
   Vuilleumier P, 2002, NEUROPSYCHOLOGIA, V40, P2156, DOI 10.1016/S0028-3932(02)00045-3
   Vuilleumier P, 2005, TRENDS COGN SCI, V9, P585, DOI 10.1016/j.tics.2005.10.011
   Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66
   Whalen PJ, 1998, J NEUROSCI, V18, P411
   Wicker B, 2008, SOC COGN AFFECT NEUR, V3, P135, DOI 10.1093/scan/nsn007
   Williams LM, 2004, HUM BRAIN MAPP, V21, P64, DOI 10.1002/hbm.10154
   Williams MA, 2004, EXP BRAIN RES, V154, P403, DOI 10.1007/s00221-003-1740-x
   Winkielman P, 1997, COGNITION EMOTION, V11, P433
   Winkielman P, 2009, EMOT REV, V1, P178, DOI 10.1177/1754073908100442
   Wong TKW, 2008, EUR J NEUROSCI, V28, P407, DOI 10.1111/j.1460-9568.2008.06328.x
   Wright B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041326
   Zbrozyna A. W., 1963, PROGRESS BRAIN RESEA, V3, P50, DOI 10.1016/S0079-6123(08)60566-X
NR 118
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD SEP
PY 2014
VL 101
BP 24
EP 35
DI 10.1016/j.biopsycho.2014.07.003
PG 12
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
SC Psychology; Behavioral Sciences
GA AN8FM
UT WOS:000340838800005
PM 25017502
ER

PT J
AU Gabriele, S
   Sacco, R
   Cerullo, S
   Neri, C
   Urbani, A
   Tripi, G
   Malvy, J
   Barthelemy, C
   Bonnet-Brilhault, F
   Persico, AM
AF Gabriele, Stefano
   Sacco, Roberto
   Cerullo, Sonia
   Neri, Cristina
   Urbani, Andrea
   Tripi, Gabriele
   Malvy, Joelle
   Barthelemy, Catherine
   Bonnet-Brilhault, Frederique
   Persico, Antonio M.
TI Urinary p-cresol is elevated in young French children with autism
   spectrum disorder: a replication study
SO BIOMARKERS
LA English
DT Article
DE Gut flora; neurotoxicity; organic contaminants; p-cresylsulfate;
   pervasive developmental disorders
ID INTESTINAL PERMEABILITY; DEVELOPMENTAL DISORDERS; PROPIONIC-ACID;
   CRESYLSULPHATE; BEHAVIOR; DISEASE; ABNORMALITIES; BIOMARKERS; SULFATION;
   SYMPTOMS
AB The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex-and age-matched controls (p<0.05). This increase was limited to ASD children aged <= 8 years (p<0.01), and not older (p=0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic, compulsive/repetitive behaviors (p<0.05), although not with overall autism severity. These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.
C1 [Gabriele, Stefano; Sacco, Roberto; Cerullo, Sonia; Persico, Antonio M.] Univ Campus Biomed, Unit Child & Adolescent NeuroPsychiat, I-00128 Rome, Italy.
   [Gabriele, Stefano; Sacco, Roberto; Cerullo, Sonia; Persico, Antonio M.] Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, I-00128 Rome, Italy.
   [Neri, Cristina; Urbani, Andrea] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
   [Neri, Cristina; Urbani, Andrea] IRCCS Fdn S Lucia, Dept Expt Neurosci, Rome, Italy.
   [Tripi, Gabriele] Univ Palermo, Dept PROSAMI, I-90133 Palermo, Italy.
   [Tripi, Gabriele] CH Chinon, Childhood Psychiat Serv Neurodev Disorders, Chinon, France.
   [Malvy, Joelle; Barthelemy, Catherine; Bonnet-Brilhault, Frederique] Univ Tours, Hop Bretonneau, Imagerie & Cerveau INSERM, U930, Tours, France.
   [Persico, Antonio M.] Mafalda Luce Ctr Pervas Dev Disorders, Milan, Italy.
RP Persico, AM (reprint author), Univ Campus Biomed, Unit Child & Adolescent NeuroPsychiat, Via Alvaro del Portillo 21, I-00128 Rome, Italy.
EM s.gabriele@unicampus.it; r.sacco@unicampus.it; a.persico@unicampus.it
FU Italian Ministry for University, Scientific Research and Technology
   [2008BACT54_002]; Italian Ministry of Health (CCM program, progetto
   NIDA); Fondazione Gaetano e Mafalda Luce (Milan, Italy); Autism Aid
   ONLUS (Naples, Italy); Autism Speaks (Princeton, NJ); Autism Research
   Institute (San Diego, CA); European Union (Innovative Medicines
   Initiative Joint Undertaking, EU-AIMS) [115300]
FX This work was financially supported by the Italian Ministry for
   University, Scientific Research and Technology (n.2008BACT54_002), the
   Italian Ministry of Health (CCM program 2012, progetto NIDA), the
   Fondazione Gaetano e Mafalda Luce (Milan, Italy), Autism Aid ONLUS
   (Naples, Italy), Autism Speaks (Princeton, NJ), the Autism Research
   Institute (San Diego, CA), and the European Union (Innovative Medicines
   Initiative Joint Undertaking, EU-AIMS, n. 115300). The authors declare
   no conflicts of interest. The authors alone are responsible for the
   content and writing of the paper.
CR Adrien JL, 2001, AUTISM, V5, P249, DOI 10.1177/1362361301005003003
   Alberti A, 1999, BIOL PSYCHIAT, V46, P420, DOI 10.1016/S0006-3223(98)00337-0
   Al-Lahham SH, 2010, BBA-MOL CELL BIOL L, V1801, P1175, DOI 10.1016/j.bbalip.2010.07.007
   Altieri L, 2011, BIOMARKERS, V16, P252, DOI 10.3109/1354750X.2010.548010
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707
   Barthelemy C, 1997, J AUTISM DEV DISORD, V27, P139, DOI 10.1023/A:1025887723360
   Berge-Lefranc D, 2010, J PHYS CHEM B, V114, P1661, DOI 10.1021/jp9059517
   BONE E, 1976, AM J CLIN NUTR, V29, P1448
   Bourreau Y, 2009, EUR CHILD ADOLES PSY, V18, P675, DOI 10.1007/s00787-009-0028-5
   Brunet O, 1976, DEV PSYCH PREM ENF
   Cafaro V, 2005, APPL ENVIRON MICROB, V71, P4744, DOI 10.1128/AEM.71.8.4744-4750.2005
   Chiu Cheng-An, 2010, Rev Diabet Stud, V7, P275, DOI 10.1900/RDS.2010.7.275
   De Angelis M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076993
   De Bruin A, 1976, BIOCH TOXICOLOGY ENV, P87
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   De Smet R, 2003, CLIN CHEM, V49, P470, DOI 10.1373/49.3.470
   DEufemia P, 1996, ACTA PAEDIATR, V85, P1076, DOI 10.1111/j.1651-2227.1996.tb14220.x
   Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention, 2014, MMWR SURVEILL SUMM, V63, P1
   de Wouters T, 2012, DIGEST DIS, V30, P33, DOI 10.1159/000342595
   Emond P, 2013, ANAL BIOANAL CHEM, V405, P5291, DOI 10.1007/s00216-013-6934-x
   Finegold SM, 2002, CLIN INFECT DIS, V35, P6
   Griffiths R, 1970, ABILITIES YOUNG CHIL
   Holmes E, 2008, NATURE, V453, P396, DOI 10.1038/nature06882
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Jyonouchi H, 2005, NEUROPSYCHOBIOLOGY, V51, P77, DOI 10.1159/000084164
   Jyonouchi H, 2011, J NEUROIMMUNOL, V238, P73, DOI 10.1016/j.jneuroim.2011.07.001
   Keşli Recep, 2014, J Immunoassay Immunochem, V35, P101, DOI 10.1080/15321819.2013.792834
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Liabeuf S, 2010, NEPHROL DIAL TRANSPL, V25, P1183, DOI 10.1093/ndt/gfp592
   Lord C, 2005, ADOS AUTISM DIAGNOST
   MacFabe DF, 2011, BEHAV BRAIN RES, V217, P47, DOI 10.1016/j.bbr.2010.10.005
   Mandel HG, 1971, PATHWAYS DRUG BIOTRA, P149
   Mavel S, 2013, TALANTA, V114, P95, DOI 10.1016/j.talanta.2013.03.064
   Meert N, 2012, NEPHROL DIAL TRANSPL, V27, P2388, DOI 10.1093/ndt/gfr672
   Meijers BKI, 2008, KIDNEY INT, V73, P1174, DOI 10.1038/ki.2008.31
   Neri C, URINE METABOLI UNPUB
   OECD, 2003, M P CRESOL CATEGORY
   Pascucci T, EFFECTS ACUTE UNPUB
   Perron-Borrel, 1996, EDEI R ECHELLES DIFF
   Persico AM, 2013, BEHAV BRAIN RES, V251, P95, DOI 10.1016/j.bbr.2013.06.012
   Persico AM, KEY ISSUES IN PRESS, V179
   Persico AM, 2012, NEUROTOXICOL TERATOL, V36, P82
   RAMAKRISHNA BS, 1991, GUT, V32, P46, DOI 10.1136/gut.32.1.46
   RENWICK AG, 1988, HUM TOXICOL, V7, P267
   Robertson MA, 2008, J AUTISM DEV DISORD, V38, P1066, DOI 10.1007/s10803-007-0482-1
   Ruggeri B, 2014, PSYCHOPHARMACOLOGY, V231, P1201, DOI 10.1007/s00213-013-3290-7
   Rutter M, 2005, ADI R AUTISM DIAGNOS
   Sacco R, 2010, AUTISM RES, V3, P237, DOI 10.1002/aur.151
   Schepers E, 2007, NEPHROL DIAL TRANSPL, V22, P592, DOI 10.1093/ndt/gfl584
   Schopler E., 1986, CHILDHOOD AUTISM RAT
   Selmer T, 2001, EUR J BIOCHEM, V268, P1363, DOI 10.1046/j.1432-1327.2001.02001.x
   Walsh P, 2011, NAT REV NEUROSCI, V12, P603, DOI 10.1038/nrn3113
   Wang CP, 2013, J NEPHROL, V26, P111, DOI 10.5301/jn.5000111
   Wang CP, 2010, ATHEROSCLEROSIS, V211, P579, DOI 10.1016/j.atherosclerosis.2010.03.036
   Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
   Wang Y, 2014, BRAIN BEHAV IMMUN, V38, P1, DOI 10.1016/j.bbi.2013.12.015
   Wechsler d, 2005, WISC 4 ECHELLE INTEL
   Whiteley P, 2006, PEDIATR INT, V48, P292, DOI 10.1111/j.1442-200X.2006.02207.x
   Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e
NR 60
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD SEP
PY 2014
VL 19
IS 6
BP 463
EP 470
DI 10.3109/1354750X.2014.936911
PG 8
WC Biotechnology & Applied Microbiology; Toxicology
SC Biotechnology & Applied Microbiology; Toxicology
GA AN7GZ
UT WOS:000340768500005
PM 25010144
ER

PT J
AU Roos, L
   Fang, M
   Dali, C
   Jensen, H
   Christoffersen, N
   Wu, B
   Zhang, J
   Xu, R
   Harris, P
   Xu, X
   Gronskov, K
   Tumer, Z
AF Roos, L.
   Fang, M.
   Dali, C.
   Jensen, H.
   Christoffersen, N.
   Wu, B.
   Zhang, J.
   Xu, R.
   Harris, P.
   Xu, X.
   Gronskov, K.
   Tumer, Z.
TI A homozygous mutation in a consanguineous family consolidates the role
   of ALDH1A3 in autosomal recessive microphthalmia
SO CLINICAL GENETICS
LA English
DT Article
DE ALDH1A3; exome sequencing; microphtalmia; retinoic acid
ID ANOPHTHALMIA/MICROPHTHALMIA; DEHYDROGENASE; FEATURES
AB Anomalies of eye development can lead to the rare eye malformations microphthalmia and anophthalmia (small or absent ocular globes), which are genetically very heterogeneous. Several genes have been associated with microphthalmia and anophthalmia, and exome sequencing has contributed to the identification of new genes. Very recently, homozygous variations within ALDH1A3 have been associated with autosomal recessive microphthalmia with or without cysts or coloboma, and with variable subphenotypes of developmental delay/autism spectrum disorder in eight families. In a consanguineous family where three of the five siblings were affected with microphthalmia/coloboma, we identified a novel homozygous missense mutation in ALDH1A3 using exome sequencing. Of the three affected siblings, one had intellectual disability and one had intellectual disability and autism, while the last one presented with normal development. This study contributes further to the description of the clinical spectrum associated with ALDH1A3 mutations, and illustrates the interfamilial clinical variation observed in individuals with ALDH1A3 mutations.
C1 [Roos, L.; Gronskov, K.; Tumer, Z.] Copenhagen Univ Hosp, Rigshosp, Kennedy Ctr, DK-2600 Glostrup, Denmark.
   [Fang, M.; Wu, B.; Zhang, J.; Xu, X.] BGI Shenzhen, Dept Mendelian Disorder Res, Shenzhen, Peoples R China.
   [Dali, C.] Copenhagen Univ Hosp, Rigshosp, Dept Clin Genet, Copenhagen, Denmark.
   [Jensen, H.; Christoffersen, N.] Copenhagen Univ Hosp, Rigshosp, Kennedy Ctr, Eye Clin, DK-2600 Glostrup, Denmark.
   [Xu, R.] BGI Europe, Copenhagen, Denmark.
   [Harris, P.] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark.
   [Gronskov, K.] Univ Copenhagen, Dept Cellular & Mol Med, Copenhagen, Denmark.
RP Roos, L (reprint author), Copenhagen Univ Hosp, Rigshosp, Kennedy Ctr, Gl Landevej 7, DK-2600 Glostrup, Denmark.
EM laura.kirstine.soenderberg.roos@regionh.dk
RI Harris, Pernille/G-7289-2011
OI Harris, Pernille/0000-0002-6806-4903
FU Shenzhen Municipal Government of China [GJHZ20130417140916986]
FX The project conformed to the tenets of the Declaration of Helsinki and
   was approved by the Regional Scientific Ethical Committee for
   Copenhagen, Denmark. Written informed consent was obtained. This study
   was supported by the Shenzhen Municipal Government of China (No.
   GJHZ20130417140916986).
CR Aldahmesh MA, 2013, CLIN GENET, V84, P128, DOI 10.1111/cge.12184
   Aldahmesh MA, 2012, GENET MED, V14, P900, DOI 10.1038/gim.2012.71
   Bidinost C, 2006, INVEST OPHTH VIS SCI, V47, P1274, DOI 10.1167/iovs.05-1095
   Chassaing N, 2013, CLIN GENET, V83, P244, DOI 10.1111/j.1399-0004.2012.01904.x
   Duester G, 2009, CHEM-BIOL INTERACT, V178, P178, DOI 10.1016/j.cbi.2008.09.004
   Emsley P, 2010, ACTA CRYSTALLOGR D, V66, P486, DOI 10.1107/S0907444910007493
   Fares-Taie L, 2013, AM J HUM GENET, V92, P265, DOI 10.1016/j.ajhg.2012.12.003
   Kondo Y, 2013, AM J MED GENET A, V161A, P1543, DOI 10.1002/ajmg.a.35983
   Larkin MA, 2007, BIOINFORMATICS, V23, P2947, DOI 10.1093/bioinformatics/btm404
   MCCAFFERY P, 1994, P NATL ACAD SCI USA, V91, P7772, DOI 10.1073/pnas.91.16.7772
   Medina M, 2000, GENOMICS, V63, P157, DOI 10.1006/geno.1999.6090
   Moore SA, 1998, STRUCT FOLD DES, V6, P1541, DOI 10.1016/S0969-2126(98)00152-X
   Mory A, 2013, EUR J HUM GENET, V24
   Ragge NK, 2005, AM J HUM GENET, V76, P1008, DOI 10.1086/430721
   Rhinn M, 2012, DEVELOPMENT, V139, P843, DOI 10.1242/dev.065938
   Shah SP, 2012, OPHTHALMOLOGY, V119, P362, DOI 10.1016/j.ophtha.2011.07.039
   Wagner E, 2006, EUR J NEUROSCI, V24, P329, DOI 10.1111/j.1460-9568.2006.04934.x
   Yahyavi M, 2013, HUM MOL GENET, V22, P3250, DOI 10.1093/hmg/ddt179
   Zahrani F, 2013, AM J HUM GENET, V92, P387, DOI 10.1016/j.ajhg.2013.01.008
NR 19
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9163
EI 1399-0004
J9 CLIN GENET
JI Clin. Genet.
PD SEP
PY 2014
VL 86
IS 3
BP 276
EP 281
DI 10.1111/cge.12277
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AN8YP
UT WOS:000340892300013
PM 24024553
ER

PT J
AU Carton, AM
   Smith, AD
AF Carton, Amelia Myri
   Smith, Alastair D.
TI Assessing the relationship between eating disorder psychopathology and
   autistic traits in a non-clinical adult population
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Eating disorders; Autism; Eat-26; Autism quotient; Broader phenotype
ID WEAK CENTRAL COHERENCE; SPECTRUM QUOTIENT AQ; ANOREXIA-NERVOSA;
   BULIMIA-NERVOSA; ASPERGER SYNDROME; COGNITIVE-STYLE; CHILDREN;
   INDIVIDUALS; CHILDHOOD; MIND
AB Previous research demonstrates a genetic and behavioural link between eating disorders and autism spectrum disorders, and a recent study (Coombs et al. in Br J Clin Psychol 50:326-338, 2011) extends this link to typical populations, showing a positive correlation between behaviours in typically developing children. The purpose of the present study was to examine whether this relationship continues beyond development, by studying the link between behaviours in a non-clinical adult population.
   We examined associations between performance on measures relating to autistic traits and disordered eating. Undergraduate students, equally balanced by gender and by subject studied (i.e. humanity or science), completed three tasks: to measure autistic traits, participants were administered the Embedded Figures Test (EFT) and the Autism-Spectrum Quotient (AQ). Eating disorder symptomatology was measured by the Eating Attitudes Test (Eat-26).
   Our data revealed a significant positive correlation between scores on the AQ and Eat-26. Multiple linear regressions showed that higher scores on the AQ were particularly associated with higher scores on the Bulimia & Food Preoccupation subscale of the Eat-26. EFT performance was positively related to behaviours associated with autism and eating disorders, although not reliably so.
   These data support the broader link between autistic traits and disordered eating in the non-clinical population, and demonstrate that it extends into adulthood (a time at which autistic behaviours can decrease). This work carries implications for the development of cognitive therapies for people with eating disorders.
C1 [Carton, Amelia Myri; Smith, Alastair D.] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
RP Smith, AD (reprint author), Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England.
EM alastair.smith@nottingham.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   BARONCOHEN S, 1989, J CHILD PSYCHOL PSYC, V30, P285, DOI 10.1111/j.1469-7610.1989.tb00241.x
   Berkman ND, 2007, INT J EAT DISORDER, V40, P293, DOI 10.1002/eat.20369
   Coombs E, 2011, BRIT J CLIN PSYCHOL, V50, P326, DOI 10.1348/014466510X524408
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   GARNER DM, 1982, PSYCHOL MED, V12, P871
   GILLBERG C, 1992, BEHAV NEUROL, V5, P27, DOI 10.3233/BEN-1992-5105
   GILLBERG C, 1989, DEV MED CHILD NEUROL, V31, P520
   GILLBERG C, 1994, ACTA PAEDIATR, V83, P967, DOI 10.1111/j.1651-2227.1994.tb13183.x
   Gillberg C, 1985, NORDISK PSYKIATRISK, V39, P307, DOI 10.3109/08039488509101911
   GILLBERG C, 1983, BRIT J PSYCHIAT, V142, P428
   Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
   Happe F, 2001, J CHILD PSYCHOL PSYC, V42, P299, DOI 10.1111/1469-7610.00723
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
   Harrison A, 2010, PSYCHOL MED, V40, P1887, DOI 10.1017/S0033291710000036
   Huke V, 2013, EUR EAT DISORD REV, V21, P345, DOI 10.1002/erv.2244
   Jacobi C, 2003, J AM ACAD CHILD PSY, V42, P76, DOI 10.1097/01.CHI.0000024900.60748.2F
   Joliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI DOI 10.1111/J.1469-7610.1997.TB01539.X
   Kalvya E, 2009, J AUTISM DEV DISORD, V39, P480, DOI DOI 10.1007/S10803-008-0648-5
   Keel PK, 2005, AM J PSYCHIAT, V162, P2263, DOI 10.1176/appi.ajp.162.12.2263
   Knickmeyer R, 2006, HORM BEHAV, V50, P148, DOI 10.1016/j.yhbeh.2006.02.006
   Lopez C, 2008, PSYCHOL MED, V38, P1393, DOI 10.1017/S0033291708003486
   Lopez C, 2009, J CLIN EXP NEUROPSYC, V31, P117, DOI 10.1080/13803390802036092
   Lopez CA, 2008, INT J EAT DISORDER, V41, P340, DOI 10.1002/eat.20511
   Mintz LB, 1997, J COUNS PSYCHOL, V44, P63, DOI 10.1037//0022-0167.44.1.63
   Odent M, 2010, MED HYPOTHESES, V75, P79, DOI 10.1016/j.mehy.2010.01.039
   Oldershaw A, 2011, EUR EAT DISORD REV, V19, P462, DOI 10.1002/erv.1069
   Orbitello B, 2006, INT J OBESITY, V30, P977, DOI 10.1038/sj.ijo.0803238
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
   Penas-Lledo E, 2010, J ANXIETY DISORD, V24, P767, DOI 10.1016/j.janxdis.2010.05.010
   Rastam M, 2008, CLIN NEUROPSYCHIATRY, V5, P31
   RITVO ER, 1978, J AM ACAD CHILD PSY, V17, P565, DOI 10.1016/S0002-7138(09)61011-6
   Roberts ME, 2010, J PSYCHIATR RES, V44, P964, DOI 10.1016/j.jpsychires.2010.03.001
   Roberts ME, 2007, PSYCHOL MED, V37, P1075, DOI 10.1017/S0033291707009877
   Schmidt U, 1995, HDB EATING DISORDERS
   Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
   Sobanski E, 1999, EUR CHILD ADOLES PSY, V8, P312
   Stein D, 2006, COMPR PSYCHIAT, V47, P69, DOI 10.1016/j.comppsych.2005.01.001
   STICE E, 1994, CLIN PSYCHOL REV, V14, P633, DOI 10.1016/0272-7358(94)90002-7
   Tchanturia K, 2004, J PSYCHIAT RES, V38, P545, DOI 10.1016/j.jphyschires.2004.03.001
   Tchanturia K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028331
   Tchanturia K, 2007, ANN GEN PSYCHIATR, V5, P6
   Udwin O., 2002, OUTCOMES NEURODEVELO
   Walter E, 2009, J AUTISM DEV DISORD, V39, P339, DOI 10.1007/s10803-008-0630-2
   Wentz E, 2005, EUR CHILD ADOLES PSY, V14, P431, DOI 10.1007/s00787-005-0494-3
   Wentz-Nilsson E, 1998, COMPR PSYCHIAT, V39, P392
   Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
   White SW, 2012, AUTISM, V16, P453, DOI 10.1177/1362361311431951
   Witkin MA, 1971, MANUAL EMBEDDED FIGU
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
   Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 54
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD SEP
PY 2014
VL 19
IS 3
BP 285
EP 293
DI 10.1007/s40519-013-0086-z
PG 9
WC Psychiatry
SC Psychiatry
GA AO2UN
UT WOS:000341181600002
PM 24272141
ER

PT J
AU Diolordi, L
   del Balzo, V
   Bernabei, P
   Vitiello, V
   Donini, LM
AF Diolordi, Laura
   del Balzo, Valeria
   Bernabei, Paola
   Vitiello, Valeria
   Donini, Lorenzo Maria
TI Eating habits and dietary patterns in children with autism
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Eating behavior inventory; Food consumption; Children with autism;
   Nutrition
ID SPECTRUM DISORDERS; BEHAVIOR; BRAIN
AB The children with autism have feeding problems such as chewing, preference for the same food that often are responsible for the nutrient imbalance. In this study, we have analyzed the differences in food consumption (food frequency) and eating behavior (CEBI test) between children with autism and their typically developing peers. A statistically significant difference was observed between the two groups for the consumption of milk, yogurt, pulses, rice, and fruit juices (p a parts per thousand currency sign 0,005). We observed a significant difference in the analysis of CEBI results when considering the 6- to 9.5-year-aged subgroup with autism vs control subgroup (103.50 and 110.14, respectively). The advices given by nutritionists have proved crucial to improve eating habits in children with autism, in the follow-up.
C1 [Diolordi, Laura; del Balzo, Valeria; Vitiello, Valeria; Donini, Lorenzo Maria] Univ Roma La Sapienza, Dept Expt Med, Res Unit Food Sci & Human Nutr, I-00185 Rome, Italy.
   [Bernabei, Paola] Univ Roma La Sapienza, Dept Pediat & Pediat Neuropsychiat, I-00185 Rome, Italy.
RP del Balzo, V (reprint author), Univ Roma La Sapienza, Dept Expt Med, Res Unit Food Sci & Human Nutr, Ple Aldo Moro 5, I-00185 Rome, Italy.
EM valeria.delbalzo@uniroma1.it
CR Ahearn WH, 2001, J AUTISM DEV DISORD, V31, P505, DOI 10.1023/A:1012221026124
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   ARCHER LA, 1991, J PEDIATR PSYCHOL, V16, P629, DOI 10.1093/jpepsy/16.5.629
   Arnold GL, 2003, J AUTISM DEV DISORD, V33, P449, DOI 10.1023/A:1025071014191
   Cornish E, 1998, J HUM NUTR DIET, V11, P501, DOI 10.1046/j.1365-277X.1998.00132.x
   Elder JH, 2008, NUTR CLIN PRACT, V23, P583, DOI 10.1177/0884533608326061
   ERMISCH A, 1993, PHYSIOL REV, V73, P489
   Greaves N, 2006, J INTELL DISABIL RES, V50, P92, DOI 10.1111/j.1365-2788.2005.00726.x
   Herndon AC, 2009, J AUTISM DEV DISORD, V39, P212, DOI 10.1007/s10803-008-0606-2
   Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
   Jamain S, 2002, MOL PSYCHIATR, V7, P217, DOI 10.1038/sj.mp.4000968
   L.A.R.N, 1996, LIV ASS GIORN RACC E
   Levy SE, 2008, CHILD ADOL PSYCH CL, V17, P803, DOI 10.1016/j.chc.2008.06.004
   Mari-Bauset S, 2014, J CHILD NEUROL, V29, P1554, DOI 10.1177/0883073813498821
   Marshall J, 2014, INT J SPEECH-LANG PA, V16, P151, DOI 10.3109/17549507.2013.808700
   Schreck KA, 2004, J AUTISM DEV DISORD, V34, P433, DOI 10.1023/B:JADD.0000037419.78531.86
   Schreck KA, 2006, RES DEV DISABIL, V27, P353, DOI 10.1016/j.ridd.2005.03.005
   Shimmura C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025340
   Sun Z, 1999, AUTISM, V3, P67, DOI 10.1177/1362361399003001006
   Wakefield AJ, 2002, ALIMENT PHARM THER, V16, P663, DOI 10.1046/j.1365-2036.2002.01206.x
   White JF, 2003, EXP BIOL MED, V228, P639
   ZAGON IS, 1987, BRAIN RES, V412, P68, DOI 10.1016/0006-8993(87)91440-5
NR 22
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD SEP
PY 2014
VL 19
IS 3
BP 295
EP 301
DI 10.1007/s40519-014-0137-0
PG 7
WC Psychiatry
SC Psychiatry
GA AO2UN
UT WOS:000341181600003
PM 24981567
ER

PT J
AU Park, S
   Park, JE
   Cho, SC
   Kim, BN
   Shin, MS
   Kim, JW
   Cho, IH
   Kim, SA
   Park, M
   Park, TW
   Son, JW
   Chung, US
   Yoo, HJ
AF Park, Subin
   Park, Jong-Eun
   Cho, Soo-Churl
   Kim, Bung-Nyun
   Shin, Min-Sup
   Kim, Jae-Won
   Cho, In Hee
   Kim, Soon Ae
   Park, Mira
   Park, Tae-Won
   Son, Jung-Woo
   Chung, Un-Sun
   Yoo, Hee Jeong
TI No association of the norepinephrine transporter gene (SLC6A2) and
   cognitive and behavioural phenotypes of patients with autism spectrum
   disorder
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Autism spectrum disorder; SLC6A2; Haplotype; Phenotype
ID DEFICIT HYPERACTIVITY DISORDER; TOURETTES-SYNDROME; ADHD; NET
AB We examined the association between the norepinephrine transporter (SLC6A2) gene and autism spectrum disorder (ASD) in a Korean population. In addition, we investigated which phenotypes of ASD are best attributed to the genotype of SLC6A2. A total of 184 subjects with ASD, their 156 unaffected siblings and both biological parents were recruited through university hospitals. We used the Autism Diagnostic Interview-Revised, the Aberrant Behaviour Checklist (ABC), the Child Behaviour Checklist (CBCL), the Stroop Colour-Word Interference Test and the Wisconsin Card Sorting Test (WCST) as quantitative measures of the ASD phenotypes. The associations between the quantitative measures and specific single-nucleotide polymorphisms (SNPs) were tested with linear regression analyses. We did not find any evidence of the over-transmission of either allele of the 10SLC6A2 SNPs in the DFAM test. At an empirical p value < 0.05, findings that were consistent between the linear regression analyses and the QFAM tests were the positive associations between the A allele of rs36020 and attention problems on the CBCL and stereotypical behaviours on the ABC and between the C allele of rs1814270 and the number of trials required to complete the first WCST category. However, these associations did not remain after correction for multiple testing. The study results of this study do not support the association between the SLC6A2 and the diagnosis or phenotype of ASD. However, the study must be replicated in larger populations and with using more genetic markers.
C1 [Park, Subin; Cho, Soo-Churl; Kim, Bung-Nyun; Shin, Min-Sup; Kim, Jae-Won] Seoul Natl Univ, Coll Med, Dept Psychiat, Div Child & Adolescent Psychiat, Seoul, South Korea.
   [Park, Jong-Eun; Yoo, Hee Jeong] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, Gyeonggi Do, South Korea.
   [Cho, In Hee] Samsung Child Dev Res Ctr, Dept Psychiat, Songnam, South Korea.
   [Kim, Soon Ae] Eulji Univ, Dept Pharmacol, Sch Med, Songnam, South Korea.
   [Park, Mira] Eulji Univ, Dept Prevent Med, Songnam, South Korea.
   [Park, Tae-Won] Chonbuk Natl Univ Hosp, Dept Psychiat, Jeonju, South Korea.
   [Son, Jung-Woo] Chungbuk Natl Univ Hosp, Dept Psychiat, Cheongju, South Korea.
   [Chung, Un-Sun] Kyungpook Natl Univ Hosp, Dept Psychiat, Taegu, South Korea.
RP Yoo, HJ (reprint author), Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, Gyeonggi Do, South Korea.
EM hjyoo@snu.ac.kr
FU Korea Healthcare Technology R&D project, Ministry of Health & Welfare,
   Republic of Korea [A120029]
FX This work was supported by the Korea Healthcare Technology R&D project,
   Ministry of Health & Welfare, Republic of Korea [Grant Number A120029].
CR Achenbach TM, 1991, MANUAL CHILD BEHAV C
   AMAN MG, 1985, AM J MENT DEF, V89, P492
   ANDERSON GM, 1987, MED BIOL, V65, P67
   Chappell P, 1996, BIOL PSYCHIAT, V39, P776, DOI 10.1016/0006-3223(95)00221-9
   Geschwind D, 2007, BIOL PSYCHIAT, V62, P949, DOI 10.1016/j.biopsych.2007.09.001
   Heaton RK, 1993, WISCONSIN CARD SORTI
   JHSM Kim, 2005, KOREAN J CHILD ADOLE, V16, P98
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   Kim SJ, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-8
   Kollins SH, 2008, AM J MED GENET B, V147B, P1580, DOI 10.1002/ajmg.b.30876
   Lasky-Su J, 2008, AM J MED GENET B, V147B, P1345, DOI 10.1002/ajmg.b.30867
   LECKMAN JF, 1991, ARCH GEN PSYCHIAT, V48, P324
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Madras BK, 2005, BIOL PSYCHIAT, V57, P1397, DOI 10.1016/j.biopsych.2004.10.011
   Mick E, 2008, CHILD ADOL PSYCH CL, V17, P261, DOI 10.1016/j.chc.2007.11.011
   Muthugovindan D, 2009, CURR OPIN NEUROL, V22, P131, DOI 10.1097/WCO.0b013e328326f6c8
   Oh KJ, 1997, K CBCL
   Ramoz N, 2009, NEUROPSYCHOPHARMACOL, V34, P2135, DOI 10.1038/npp.2009.39
   Shin MS, 2010, KOREAN LEITER INT PE
   Shin MS, 2007, STROOPCOLOR WORD TES
   Smith CJ, 2009, J CHILD PSYCHOL PSYC, V50, P982, DOI 10.1111/j.1469-7610.2009.02060.x
   Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
   Veenstra-VanderWeele J, 2004, MOL PSYCHIATR, V9, P819, DOI 10.1038/sj.mp.4001505
   Volkmar FR, 2001, J CLIN CHILD PSYCHOL, V30, P80, DOI 10.1207/S15374424JCCP3001_9
   Yoo HJ, 2007, KOREAN VERSION AUSTI
NR 26
TC 1
Z9 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD SEP
PY 2014
VL 264
IS 6
BP 507
EP 515
DI 10.1007/s00406-013-0480-6
PG 9
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AN8UW
UT WOS:000340881500005
PM 24381062
ER

PT J
AU Soler-Alfonso, C
   Carvalho, CMB
   Ge, J
   Roney, EK
   Bader, PI
   Kolodziejska, KE
   Miller, RM
   Lupski, JR
   Stankiewicz, P
   Cheung, SW
   Bi, WM
   Schaaf, CP
AF Soler-Alfonso, Claudia
   Carvalho, Claudia M. B.
   Ge, Jun
   Roney, Erin K.
   Bader, Patricia I.
   Kolodziejska, Katarzyna E.
   Miller, Rachel M.
   Lupski, James R.
   Stankiewicz, Pawel
   Cheung, Sau Wai
   Bi, Weimin
   Schaaf, Christian P.
TI CHRNA7 triplication associated with cognitive impairment and
   neuropsychiatric phenotypes in a three-generation pedigree
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE dosage sensitivity; copy number variation; cholinergic nervous system;
   autism spectrum disorder
ID COPY NUMBER VARIANTS; GENOME-WIDE ANALYSIS; MENTAL-RETARDATION; 15Q13.3;
   REARRANGEMENTS; DUPLICATION; RECURRENT; MICRODELETION; MECHANISMS;
   SCHIZOPHRENIA
AB Although deletions of CHRNA7 have been associated with intellectual disability (ID), seizures and neuropsychiatric phenotypes, the pathogenicity of CHRNA7 duplications has been uncertain. We present the first report of CHRNA7 triplication. Three generations of a family affected with various neuropsychiatric phenotypes, including anxiety, bipolar disorder, developmental delay and ID, were studied with array comparative genomic hybridization (aCGH). High-resolution aCGH revealed a 650-kb triplication at chromosome 15q13.3 encompassing the CHRNA7 gene, which encodes the alpha7 subunit of the neuronal nicotinic acetylcholine receptor. A small duplication precedes the triplication at the proximal breakpoint junction, and analysis of the breakpoint indicates that the triplicated segment is in an inverted orientation with respect to the duplication. CHRNA7 triplication appears to occur by a replication-based mechanism that produces inverted triplications embedded within duplications. Co-segregation of the CHRNA7 triplication with neuropsychiatric and cognitive phenotypes provides further evidence for dosage sensitivity of CHRNA7.
C1 [Soler-Alfonso, Claudia] Univ Texas Hlth Sci Ctr Houston, Div Med Genet, Dept Pediat, Houston, TX 77030 USA.
   [Carvalho, Claudia M. B.; Ge, Jun; Roney, Erin K.; Kolodziejska, Katarzyna E.; Lupski, James R.; Stankiewicz, Pawel; Cheung, Sau Wai; Bi, Weimin; Schaaf, Christian P.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
   [Carvalho, Claudia M. B.] Fiocruz MS, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil.
   [Bader, Patricia I.; Miller, Rachel M.] Genet Ctr, Parkview Hlth Labs, Ft Wayne, IN USA.
   [Lupski, James R.] Texas Childrens Hosp, Dept Pediat, Houston, TX 77030 USA.
   [Schaaf, Christian P.] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA.
RP Schaaf, CP (reprint author), Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, 1250 Moursund St,Suite 1350, Houston, TX 77030 USA.
EM Schaaf@bcm.edu
FU Doris Duke Clinical Scientist Development Award; NIH [HD037283]; US
   National Institute of Neurological Disorders and Stroke [NS058529]
FX We are indebted to the family who participated in this study. Dr
   Schaaf's work is generously supported by the Joan and Stanford Alexander
   Family. Dr Schaaf is also a recipient of a Doris Duke Clinical Scientist
   Development Award. NIH grant HD037283 supported Dr Ge's work in the
   laboratory of Dr Arthur Beaudet. In addition, this work was supported in
   part by US National Institute of Neurological Disorders and Stroke grant
   NS058529 to JRL.
CR Ben-Shachar S, 2009, J MED GENET, V46, P382, DOI 10.1136/jmg.2008.064378
   Beunders G, 2010, J MED GENET, V47, P271, DOI 10.1136/jmg.2009.070490
   Bi WM, 2009, NAT GENET, V41, P168, DOI 10.1038/ng.302
   Boone PM, 2010, HUM MUTAT, V31, P1326, DOI 10.1002/humu.21360
   Carvalho CMB, 2009, HUM MOL GENET, V18, P2188, DOI 10.1093/hmg/ddp151
   Carvalho CMB, 2011, NAT GENET, V43, P1074, DOI 10.1038/ng.944
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Crespi BJ, 2010, BRIT J PSYCHIAT, V196, P495, DOI 10.1192/bjp.196.6.495
   del Gaudio D, 2006, GENET MED, V8, P784, DOI 10.1097/01.gim.0000250502.28516.3c
   Dittwald P, 2013, HUM MUTAT, V34, P210, DOI 10.1002/humu.22217
   Girirajan S, 2007, CLIN GENET, V72, P47, DOI 10.1111/j.1399-0004.2007.00831.x
   Hastings PJ, 2009, NAT REV GENET, V10, P551, DOI 10.1038/nrg2593
   Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
   Kern WR, 2000, BEHAV BRAIN RES, V113, P169
   Lin H, 2010, P NATL ACAD SCI USA, V107, P16661, DOI 10.1073/pnas.1007397107
   Liu PF, 2012, CURR OPIN GENET DEV, V22, P211, DOI [10.1016/j.gde.2012.02.012, 10.1016/j.gde.20112.02.012]
   Liu PF, 2011, HUM MOL GENET, V20, P1975, DOI 10.1093/hmg/ddr078
   Lupski JR, 2012, BIOL PSYCHIAT, V72, P617, DOI 10.1016/j.biopsych.2012.08.007
   Reddy KS, 2000, CLIN GENET, V58, P134, DOI 10.1034/j.1399-0004.2000.580208.x
   Sahoo T, 2011, GENET MED, V13, P868, DOI 10.1097/GIM.0b013e3182217a06
   Schaaf CP, 2011, ANNU REV GENOM HUM G, V12, P25, DOI 10.1146/annurev-genom-092010-110715
   Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
   Sharp AJ, 2008, NAT GENET, V40, P322, DOI 10.1038/ng.93
   Shimojima K, 2012, EUR J MED GENET, V55, P400, DOI 10.1016/j.ejmg.2012.02.013
   Shinawi M, 2009, NAT GENET, V41, P1269, DOI 10.1038/ng.481
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   Szafranski P, 2010, HUM MUTAT, V31, P840, DOI 10.1002/humu.21284
   van Bon BWM, 2009, J MED GENET, V46, P511, DOI 10.1136/jmg.2008.063412
   Vinals X, 2012, DRUG ALCOHOL DEPEN, V122, P247, DOI 10.1016/j.drugalcdep.2011.09.027
   Williams NM, 2012, AM J PSYCHIAT, V169, P195, DOI 10.1176/appi.ajp.2011.11060822
   Yobb TM, 2005, AM J HUM GENET, V76, P865, DOI 10.1086/429841
   Zoghbi HY, 2010, NEURON, V68, P165, DOI 10.1016/j.neuron.2010.10.015
NR 32
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD SEP
PY 2014
VL 22
IS 9
BP 1071
EP 1076
DI 10.1038/ejhg.2013.302
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AN4SA
UT WOS:000340577600004
PM 24424125
ER

PT J
AU Wang, Y
   Fang, YD
   Zhang, FL
   Xu, M
   Zhang, JZ
   Yan, JB
   Ju, WN
   Brown, WT
   Zhong, N
AF Wang, Yu
   Fang, Yudan
   Zhang, Fengling
   Xu, Miao
   Zhang, Jingzhi
   Yan, Jingbin
   Ju, Weina
   Brown, W. Ted
   Zhong, Nanbert
TI Hypermethylation of the enolase gene (ENO2) in autism
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Autism; Neurodevelopment; Gene ENO2; Methylation; Epigenetics
ID MECP2 PROMOTER METHYLATION; REVEALS; SCHIZOPHRENIA; EXPRESSION;
   BIOMARKERS; CORTEX; SERUM
AB It has been hypothesized that dysregulation of brain-expressed genes is the major predisposing underlying mechanism for autism. This dysregulation may be mediated by differential methylation of CpG sites within gene promoters, which could be candidate biomarkers and used for early clinical screening of autism. A total of 131 pairs of age- and sex-matched autistic and control subjects were recruited in this study. Peripheral blood cells were analyzed. The first five pairs were randomly applied to array-based genome-wide methylation studies. A neuron-specific gene, ENO2, was found to be hypermethylated in the autistic samples. This difference was validated by bisulfite sequencing PCR (BSP). The differential expression of ENO2 gene was further analyzed with RT-qPCR and ELISA. The hypermethylation of ENO2 within the promoter region was confirmed by BSP to be present in 14.5 % (19/131) of the total of the autistic samples. The mean ENO2 RNA level in these 19 autistic samples was reduced by about 70 % relative to that in controls. The average level of ENO2 protein expression in the 19 autistic samples (15.18 +/- 3.51 mu g/l) was about half of that in the controls (33.86 +/- 8.16 mu g/l). Conclusion: These findings suggest that reduced ENO2 expression may be a biomarker for a subset of autistic children.
C1 [Wang, Yu; Fang, Yudan; Xu, Miao; Zhang, Jingzhi; Yan, Jingbin; Zhong, Nanbert] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Inst Med Genet, Shanghai 200040, Peoples R China.
   [Wang, Yu; Zhang, Fengling; Zhong, Nanbert] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Inst Children Hlth Care, Shanghai 200040, Peoples R China.
   [Wang, Yu; Fang, Yudan; Xu, Miao; Zhang, Jingzhi; Yan, Jingbin; Zhong, Nanbert] Minist Hlth, Key Lab Embryo Mol Biol, Shanghai, Peoples R China.
   [Wang, Yu; Fang, Yudan; Xu, Miao; Zhang, Jingzhi; Yan, Jingbin; Zhong, Nanbert] Shanghai Lab Embryo & Reprod Engn, Shanghai, Peoples R China.
   [Zhong, Nanbert] Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China.
   [Ju, Weina; Brown, W. Ted; Zhong, Nanbert] New York State Inst Basic Res Dev Disabil, New York, NY USA.
RP Zhong, N (reprint author), Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Inst Children Hlth Care, 1440 Beijing West Rd, Shanghai 200040, Peoples R China.
EM wy_rain@126.com; fangyudan@hotmail.com; zhangfl3985@126.com;
   xumiao@shhildren.com.cn; zhangjz@shchildren.com.cn;
   yanjingbin0130@hotmail.com; weina.ju@yahoo.com; ted.brown@opwdd.ny.gov;
   nanbert.zhong@opwdd.ny.gov
FU National "973" program - Chinese Ministry of Science and Technology
   [2012CB517905]; Shanghai Municipal Department of Science and Technology
   [2009JC1412600]; Shanghai Municipal Health Bureau [2010Y151]; New York
   State Office for People with Developmental Disabilities (OPWDD)
FX We thank the autism and control children and their parents for making
   this study feasible. We are extremely grateful to Professors Yitao Zeng
   and Shuzhen Huang (Shanghai Institute of Medical Genetics) for helpful
   discussions. This study was supported in part by the National "973"
   program (2012CB517905) granted from the Chinese Ministry of Science and
   Technology, and funding from the Shanghai Municipal Department of
   Science and Technology (2009JC1412600), Shanghai Municipal Health Bureau
   (2010Y151), and New York State Office for People with Developmental
   Disabilities (OPWDD).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Chowdhury S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016506
   Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
   Ganz ML, 2006, AUTISM BASIC NEUROSC, P76
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Gomes MVM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052570
   Henikoff S, 1997, TRENDS GENET, V13, P293, DOI 10.1016/S0168-9525(97)01219-5
   Junaid MA, 2004, AM J MED GENET A, V131A, P11, DOI 10.1002/ajmg.a.30349
   Kuehn BM, 2007, JAMA-J AM MED ASSOC, V297, P940, DOI 10.1001/jama.297.9.940
   Liao DL, 2011, ADDICT BIOL, DOI [10.1111/j.1369-600, DOI 10.1111/J.1369-600]
   Martins-De-Souza D, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-17
   Martins-de-Souza D, 2010, J PSYCHIATR RES, V44, P989, DOI 10.1016/j.jpsychires.2010.03.003
   Mill J, 2008, AM J HUM GENET, V82, P696, DOI 10.1016/j.ajhg.2008.01.008
   Momeni N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.19
   Nagarajan RP, 2008, AUTISM RES, V1, P169, DOI 10.1002/aur.24
   Nagarajan RP, 2006, EPIGENETICS-US, V1, P172
   Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
   Ptak Carolyn, 2010, Dialogues Clin Neurosci, V12, P25
   Rajendram R, 2011, EPIGENETICS-US, V6, P410, DOI 10.4161/epi.6.4.14763
   Sandler SJI, 2010, CHILD NERV SYST, V26, P205, DOI 10.1007/s00381-009-1009-1
   Schanen NC, 2006, HUM MOL GENET, V15, P138, DOI DOI 10.1093/HMG/DDL213
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Shen C, 2010, J MOL NEUROSCI, V43, P443
   Spivak B, 2009, NEUROPSYCHOBIOLOGY, V60, P49, DOI 10.1159/000235802
   Sung HJ, 2008, BMB REP, V41, P615
   Suzuki MM, 2008, NAT REV GENET, V9, P465, DOI 10.1038/nrg2341
   Takeshima H, 2009, GENOME RES, V19, P1974, DOI 10.1101/gr.093310.109
   Toperoff G, 2012, HUM MOL GENET, V21, P371, DOI 10.1093/hmg/ddr472
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wang Y, 2012, MUTATIONS HUMAN GENE, P217
NR 31
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD SEP
PY 2014
VL 173
IS 9
BP 1233
EP 1244
DI 10.1007/s00431-014-2311-9
PG 12
WC Pediatrics
SC Pediatrics
GA AN5ZU
UT WOS:000340673300014
PM 24737292
ER

PT J
AU Del Giudice, M
   Klimczuk, ACE
   Traficonte, DM
   Maestripieri, D
AF Del Giudice, Marco
   Klimczuk, Amanda C. E.
   Traficonte, Daniel M.
   Maestripieri, Dario
TI Autistic-like and schizotypal traits in a life history perspective:
   diametrical associations with impulsivity, sensation seeking, and
   sociosexual behavior
SO EVOLUTION AND HUMAN BEHAVIOR
LA English
DT Article
DE Autistic-like traits; Diametrical model; Impulsivity; Life history
   strategy; Schizotypal traits; Sexual selection; Sociosexuality
ID SPECTRUM QUOTIENT AQ; MALE BRAIN THEORY; PHENOTYPIC PLASTICITY;
   GENERAL-POPULATION; GENETIC-VARIATION; SEX-DIFFERENCES; PERSONALITY;
   SCHIZOPHRENIA; DISORDER; CREATIVITY
AB According to recent theoretical models, autistic-like and schizotypal traits can be regarded as opposite sides of a single continuum of variation in personality and cognition, and may be diametrically associated with individual differences in life history strategies. In this view, schizotypy is a psychological phenotype oriented toward high mating effort and reduced parenting, consistent with a fast life history strategy, whereas autistic-like traits contribute to a slow strategy characterized by reduced mating effort and high parental investment. In this study, we tested the hypothesis that autistic-like and schizotypal traits would be diametrically associated with unrestricted sociosexuality, impulsivity, and sensation seeking (three key behavioral correlates of fast life history strategies in humans) in a sample of 152 young adults (18-38 years). The results were consistent with a diametrical autism-schizotypy axis of individual variation. In line with our hypotheses, autism-schizotypy scores were uniquely associated with individual differences in impulsivity, sensation seeking, and sociosexual behavior, even after controlling for variation in Big Five personality traits. However, we found no significant associations with sociosexual attitude in the present sample. Our findings provide additional support for a life history model of autistic-like and schizotypal traits and demonstrate the heuristic value of this approach in the study of personality and psychopathology. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Del Giudice, Marco] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA.
   [Klimczuk, Amanda C. E.; Maestripieri, Dario] Univ Chicago, Inst Mind & Biol, Chicago, IL 60637 USA.
   [Traficonte, Daniel M.] Univ Chicago, Ctr Global Hlth, Chicago, IL 60637 USA.
RP Del Giudice, M (reprint author), Univ New Mexico, Dept Psychol, Logan Hall,2001 Redondo Dr NE, Albuquerque, NM 87131 USA.
EM marcodg@unm.edu
RI Del Giudice, Marco/F-7007-2010
OI Del Giudice, Marco/0000-0001-8526-1573
CR Aleman A, 2003, ARCH GEN PSYCHIAT, V60, P565, DOI 10.1001/archpsyc.60.6.565
   Archer J, 2003, REV GEN PSYCHOL, V7, P219, DOI 10.1037/1089-2680.7.3.219
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Bejerot S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087961
   Brosnan M, 2010, J AUTISM DEV DISORD, V40, P1, DOI 10.1007/s10803-009-0815-3
   Carroll LS, 2009, GENOME MED, V1, DOI 10.1186/gm102
   Claridge G., 1997, SCHIZOTYPY IMPLICATI
   COSTA PT, 1995, J PERS ASSESS, V64, P21, DOI 10.1207/s15327752jpa6401_2
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Crespi B, 2010, P NATL ACAD SCI USA, V107, P1736, DOI 10.1073/pnas.0906080106
   Crespi B, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-119
   Crespi BJ, 2011, HANDBOOK OF SCHIZOPHRENIA SPECTRUM DISORDERS, VOL 1, P163, DOI 10.1007/978-94-007-0837-2_7
   Cross CP, 2011, PSYCHOL BULL, V137, P97, DOI 10.1037/a0021591
   DARTON RA, 1980, STATISTICIAN, V29, P167, DOI 10.2307/2988040
   Del Giudice M., BIOBEHAVIORAL FDN SE
   Del Giudice M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0016040
   Del Giudice M., PSYCHOL INQ IN PRESS
   Del Giudice M, 2010, FRONT PSYCHOL, V1, DOI 10.3389/fpsyg.2010.00041
   Del Giudice M, 2012, J THEOR BIOL, V297, P48, DOI 10.1016/j.jtbi.2011.12.004
   DeYoung C. G, 2011, HDB SELF REGULATION, P485
   Dinsdale NL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063316
   Draghi JA, 2012, EVOLUTION, V66, P2891, DOI 10.1111/j.1558-5646.2012.01649.x
   Ellis BJ, 2009, HUM NATURE-INT BIOS, V20, P204, DOI 10.1007/s12110-009-9063-7
   ELLNER S, 1994, AM NAT, V143, P403, DOI 10.1086/285610
   Ericson M, 2011, BEHAV GENET, V41, P499, DOI 10.1007/s10519-010-9401-x
   EYSENCK SBG, 1978, PSYCHOL REP, V43, P1247
   Fletcher-Watson S, 2012, BRIT J DEV PSYCHOL, V30, P446, DOI 10.1111/j.2044-835X.2011.02054.x
   Gilman SR, 2012, NAT NEUROSCI, V15, P1723, DOI 10.1038/nn.3261
   Handcock MS, 1998, SOCIOL METHODOL, V28, P53, DOI 10.1111/0081-1750.00042
   Happe F, 2009, PHILOS T R SOC B, V364, P1369, DOI 10.1098/rstb.2008.0332
   Haselton MG, 2006, HUM NATURE-INT BIOS, V17, P50, DOI 10.1007/s12110-006-1020-0
   Hellemans H, 2007, J AUTISM DEV DISORD, V37, P260, DOI 10.1007/s10803-006-0159-1
   Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
   Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
   Hurst RM, 2007, PERS INDIV DIFFER, V43, P1938, DOI 10.1016/j.paid.2007.06.012
   Jackson JJ, 2007, EVOL HUM BEHAV, V28, P382, DOI 10.1016/j.evolhumbehav.2007.04.005
   Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
   John O. P., 1991, BIG 5 INVENTORY VERS
   Kalkman HO, 2012, NEUROSCI BIOBEHAV R, V36, P2206, DOI 10.1016/j.neubiorev.2012.07.008
   Kaplan HS, 2005, HDB EVOLUTIONARY PSY, P68
   Keller MC, 2006, BEHAV BRAIN SCI, V29, P385, DOI 10.1017/S0140525X06009095
   Kinney D. K., 2001, CREATIVITY RES J, V13, P17, DOI [10.1207/S15326934CRJ1301_3, DOI 10.1207/S15326934CRJ1301_3]
   Kyaga S, 2011, BRIT J PSYCHIAT, V199, P373, DOI 10.1192/bjp.bp.110.085316
   Lalasz CB, 2011, PERS INDIV DIFFER, V50, P1079, DOI 10.1016/j.paid.2011.01.029
   Lee HJ, 2003, BEHAV RES THER, V41, P11, DOI 10.1016/S0005-7967(01)00101-2
   Lejuez CW, 2002, J EXP PSYCHOL-APPL, V8, P75, DOI 10.1037//1076-898X.8.2.75
   MEEHL PE, 1962, AM PSYCHOL, V17, P827, DOI 10.1037/h0041029
   Miller GF, 2007, SCHIZOPHR RES, V93, P317, DOI 10.1016/j.schres.2007.02.007
   Nettle D, 2006, P ROY SOC B-BIOL SCI, V273, P611, DOI 10.1098/rspb.2005.3349
   Nettle D, 2006, J RES PERS, V40, P876, DOI 10.1016/j.jrp.2005.09.004
   Nettle D, 2006, BEHAV BRAIN SCI, V29, P418, DOI 10.1017/S0140525X06359092
   Nettle D., 2001, STRONG IMAGINATION M
   Penke L, 2008, J PERS SOC PSYCHOL, V95, P1113, DOI 10.1037/0022-3514.95.5.1113
   Pollmann M. M. H., 2009, J AUTISM DEV DISORD, V40, P470
   R Core Team, 2012, R LANG ENV STAT COMP
   RAINE A, 1991, SCHIZOPHRENIA BULL, V17, P555
   Rawlings D, 2008, J RES PERS, V42, P465, DOI 10.1016/j.jrp.2007.06.005
   Reale D, 2010, PHILOS T R SOC B, V365, P4051, DOI 10.1098/rstb.2010.0208
   Ronald A, 2011, MOL PSYCHIATR, V16, P1039, DOI 10.1038/mp.2010.82
   Russell DW, 2002, PERS SOC PSYCHOL B, V28, P1629, DOI 10.1177/014616702237645
   Russell-Smith SN, 2011, PERS INDIV DIFFER, V51, P128, DOI 10.1016/j.paid.2011.03.027
   Russell-Smith SN, 2010, J AUTISM DEV DISORD, V40, P968, DOI 10.1007/s10803-010-0945-7
   Russell-Smith SN, 2013, J AUTISM DEV DISORD, V43, P695, DOI 10.1007/s10803-012-1614-9
   Shaner A, 2004, SCHIZOPHR RES, V70, P101, DOI 10.1016/j.schres.2003.09.014
   Stearns SC, 1992, EVOLUTION LIFE HIST
   Stevenson JL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059329
   Stokes M, 2007, J AUTISM DEV DISORD, V37, P1969, DOI 10.1007/s10803-006-0344-2
   Svanback R, 2009, AM NAT, V174, P176, DOI 10.1086/600112
   van Os J, 2009, PSYCHOL MED, V39, P179, DOI 10.1017/S0033291708003814
   Wakabayashi A, 2012, RES AUTISM SPECT DIS, V6, P717, DOI 10.1016/j.rasd.2011.09.008
   Westen D, 2001, AM J PSYCHIAT, V158, P547, DOI 10.1176/appi.ajp.158.4.547
   Whiteside SP, 2001, PERS INDIV DIFFER, V30, P669, DOI 10.1016/S0191-8869(00)00064-7
   Wing L, 1988, ASPECTS AUTISM BIOL
   Zhai JG, 2011, BEHAV BRAIN RES, V217, P363, DOI 10.1016/j.bbr.2010.11.004
   Zimbardo PG, 1999, J PERS SOC PSYCHOL, V77, P1271, DOI 10.1037//0022-3514.77.6.1271
NR 77
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1090-5138
EI 1879-0607
J9 EVOL HUM BEHAV
JI Evol. Hum. Behav.
PD SEP
PY 2014
VL 35
IS 5
BP 415
EP 424
DI 10.1016/j.evolhumbehav.2014.05.007
PG 10
WC Psychology, Biological; Behavioral Sciences; Social Sciences, Biomedical
SC Psychology; Behavioral Sciences; Biomedical Social Sciences
GA AN6EG
UT WOS:000340687100009
ER

PT J
AU Buchanan, R
   Beckett, RD
AF Buchanan, Rachel
   Beckett, Robert D.
TI Assessment of vaccination-related information for consumers available on
   Facebook (R)
SO HEALTH INFORMATION AND LIBRARIES JOURNAL
LA English
DT Article
DE consumer health information; health information needs; information
   seeking behaviour; social media; social networking
ID PERTUSSIS; VACCINES; RUBELLA; AUTISM
AB Objectives: To assess the magnitude, interest, purpose and validity of vaccination-related information on Facebook and to determine whether information varies by site viewpoint.
   Methods: The 10 largest vaccination-focused Facebook (R) pages, groups and places in each category were identified and classified by viewpoint (i.e. anti-, pro-, neutral) and purpose. Number of members, posts per week, likes, comments and shares per post were recorded. Posts were assessed for concordance with CDC and FDA recommendations.
   Results: Of 30 sites, 43% (n = 13) were anti-vaccination, 7% (n = 2) neutral and 50% (n = 15) pro-vaccination. Most sites were most popular with American users. Median members were similar between anti-vaccination (2703 members, range 337-33 631 members) and pro-vaccination sites (2142 members, range 456-61 565 members, P = 0.262); however, anti-vaccination sites accumulated more posts per week by authors (median 15 vs. 3, P = 0.031) and members (median 33 vs. 1, P < 0.001). Pro-vaccination sites more commonly had commercial purpose (53% [n = 8] vs. 8% [n = 1], P = 0.02). Anti-vaccination sites more commonly gave medical advice (54% [n = 7] vs. 0%, P = 0.004). Overall, 48% (n = 22) of author posts were concordant with regulatory recommendations; concordance was more common on pro-vaccination sites (78% [n = 21] vs. 5% [n = 1], P = 0.0002).
   Conclusion: Vaccination-related information is prevalent on Facebook regardless of viewpoint; however, anti-vaccination information generates more interest. Anti-vaccination sites were likely to provide medical advice and disagree with regulatory bodies.
C1 [Buchanan, Rachel] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA.
   [Beckett, Robert D.] Univ Manchester, Coll Pharm, Ft Wayne, IN 46845 USA.
RP Beckett, RD (reprint author), Univ Manchester, Coll Pharm, 10627 Diebold Rd, Ft Wayne, IN 46845 USA.
EM rdbeckett@manchester.edu
CR [Anonymous], NEWSR KEY FACTS
   Bardenheier B, 2004, ARCH PEDIAT ADOL MED, V158, P569, DOI 10.1001/archpedi.158.6.569
   California Department of Public of Health, PERT SUMM REP
   Centers for Disease Control, SOM COMM MISC VACC R
   Centers for Disease Control, VACC SAF
   Cohen R. A., 2009, NCHS DATA BRIEF USE
   Diekema DS, 2012, NEW ENGL J MED, V366, P391, DOI 10.1056/NEJMp1113008
   Fox S., HLTH ONLINE
   Hornig M, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003140
   Madsen KM, 2003, PEDIATRICS, V112, P604, DOI 10.1542/peds.112.3.604
   Minnesota Department of Health, MINN VACC CHILDR
   National Network for Immunization Information, VACC MIS
   Rochman B., TIME HLTH FAMILY
   STRATTON KR, 1994, JAMA-J AM MED ASSOC, V271, P1602, DOI 10.1001/jama.271.20.1602
   The College of Physicians of Philadelphia, HIST VACC
NR 15
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1471-1834
EI 1471-1842
J9 HEALTH INFO LIBR J
JI Heatlth Info. Libr. J.
PD SEP
PY 2014
VL 31
IS 3
BP 227
EP 234
DI 10.1111/hir.12073
PG 8
WC Information Science & Library Science
SC Information Science & Library Science
GA AO2KV
UT WOS:000341151500006
PM 25041499
ER

PT J
AU Micheau, J
   Vimeney, A
   Normand, E
   Mulle, C
   Riedel, G
AF Micheau, Jacques
   Vimeney, Alice
   Normand, Elisabeth
   Mulle, Christophe
   Riedel, Gernot
TI Impaired Hippocampus-Dependent Spatial Flexibility and Sociability
   Represent Autism-Like Phenotypes in GluK2 Mice
SO HIPPOCAMPUS
LA English
DT Article
DE GluK2 KO mice; autism spectrum disorder; social behavior; behavioral
   flexibility; spatial learning; pattern separation/completion; water maze
ID FAMILY-BASED ASSOCIATION; MOSSY FIBER SYNAPSES; GLUTAMATE-RECEPTOR-6
   GENE; SPECTRUM DISORDERS; PATTERN SEPARATION; KAINATE RECEPTORS;
   GLUR6-DEFICIENT MICE; GRIK2 POLYMORPHISMS; BASAL GANGLIA; MEMORY
AB Autism is a complex neurodevelopmental disorder with high heritability. grik2 (which encodes the GluK2 subunit of kainate receptors) has been identified as a susceptibility gene in Autism Spectrum Disorders (ASD), but its role in the core and associated symptoms of ASD still remains elusive. We used mice lacking GluK2 (GluK2 KO) to examine their endophenotype with a view to modeling aspects of autism, including social deficits, stereotyped and repetitive behavior and decreased cognitive abilities. Anxiety was recorded in the elevated plus maze, social behavior in a three-chamber apparatus, and cognition in different water maze protocols. Deletion of the GluK2 gene reduced locomotor activity and sociability as indicated by the social interaction task. In addition, GluK2 KO mice learnt to locate a hidden platform in a water maze surrounded by a curtain with hanging cues faster than wild-type mice. They maintained a bias toward the target quadrant when some of these cues were removed, at which point wild-types orthogonalized the behavior and showed no memory. However, GluK2 KO mice were impaired in spatial reversal learning. These behavioral data together with previously published electrophysiology showing severe anomalies in CA3 network activity, suggest a computational shift in this network for enhanced propensity of pattern completion that would explain the loss of behavioral flexibility in GluK2 KO mice. Although a single mutation cannot recapitulate the entire core symptoms of ASD, our data provide evidence for glutamatergic dysfunction underlying a number of social-and cognition-related phenotypes relevant to ASD. (C) 2014 Wiley Periodicals, Inc.
C1 [Micheau, Jacques] Univ Bordeaux, INCIA, CNRS, UMR 5287, F-33405 Talence, France.
   [Vimeney, Alice; Normand, Elisabeth; Mulle, Christophe] Univ Bordeaux, Inst Interdisciplinaire Neurosci, CNRS, UMR 5297, F-33077 Bordeaux, France.
   [Riedel, Gernot] Univ Aberdeen, Sch Med Sci, Aberdeen AB25 2ZD, Scotland.
RP Micheau, J (reprint author), Univ Bordeaux, INCIA, CNRS, UMR 5287, Ave Fac, F-33405 Talence, France.
EM jacques.micheau@u-bordeaux1.fr
FU Centre National de la Recherche Scientifique; Universite de Bordeaux
FX This study was supported by the Centre National de la Recherche
   Scientifique and Universite de Bordeaux. We thank D. Panzeri, N. Argenta
   and J. Huard for animal care.
CR Bailey A, 2001, EUR J PHARMACOL, V431, P305, DOI 10.1016/S0014-2999(01)01463-7
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Benes FM, 2001, HIPPOCAMPUS, V11, P482, DOI 10.1002/hipo.1065
   Beneyto M, 2007, NEUROPSYCHOPHARMACOL, V32, P1888, DOI 10.1038/sj.npp.1301312
   Bischoff S, 1997, J COMP NEUROL, V379, P541, DOI 10.1002/(SICI)1096-9861(19970324)379:4<541::AID-CNE6>3.0.CO;2-2
   Bostan AC, 2013, TRENDS COGN SCI, V17, P241, DOI 10.1016/j.tics.2013.03.003
   Carlson GC, 2012, PHARMACOL BIOCHEM BE, V100, P850, DOI 10.1016/j.pbb.2011.02.003
   Caron MJ, 2004, NEUROPSYCHOLOGIA, V42, P467, DOI 10.1016/j.neuropsychologia.2003.08.015
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Contractor A, 2001, NEURON, V29, P209, DOI 10.1016/S0896-6273(01)00191-X
   Contractor A, 2011, TRENDS NEUROSCI, V34, P154, DOI 10.1016/j.tins.2010.12.002
   Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x
   de Bruin N, 2006, BEHAV BRAIN RES, V172, P122, DOI 10.1016/j.bbr.2006.05.002
   Dutta S, 2007, CELL MOL NEUROBIOL, V27, P1035, DOI 10.1007/s10571-007-9193-6
   Ey E, 2011, AUTISM RES, V4, P5, DOI 10.1002/aur.175
   Goh S, 2012, DEV MED CHILD NEUROL, V54, P208, DOI 10.1111/j.1469-8749.2011.04153.x
   Guzowski JF, 2004, NEURON, V44, P581, DOI 10.1016/j.neuron.2004.11.003
   Holt R, 2011, EMBO MOL MED, V3, P438, DOI 10.1002/emmm.201100157
   Holt R, 2010, EUR J HUM GENET, V18, P1013, DOI 10.1038/ejhg.2010.69
   Hunsaker MR, 2009, BEHAV BRAIN RES, V201, P192, DOI 10.1016/j.bbr.2009.02.012
   Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
   Kim SA, 2007, NEUROSCI RES, V58, P332, DOI 10.1016/j.neures.2007.03.002
   Ko S, 2005, J NEUROSCI, V25, P977, DOI 10.1523/JNEUROSCI.4059-04.2005
   Leutgeb JK, 2007, SCIENCE, V315, P961, DOI 10.1126/science.1135801
   Leutgeb S, 2007, LEARN MEMORY, V14, P745, DOI 10.1101/lm.703907
   McNaughton B.L., 1990, NEUROSCIENCE CONNECT, P1
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4
   Motazacker MM, 2007, AM J HUM GENET, V81, P792, DOI 10.1086/521275
   Mulle C, 1998, NATURE, V392, P601
   Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
   Nakazawa K, 2002, SCIENCE, V297, P211, DOI 10.1126/science.1071795
   Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189
   Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805
   Riedel G, 2009, BEHAV BRAIN RES, V204, P217, DOI 10.1016/j.bbr.2009.06.012
   Sachidhanandam S, 2009, J NEUROSCI, V29, P5000, DOI 10.1523/JNEUROSCI.5807-08.2009
   Schiffer HH, 2007, AM J MED GENET B, V144B, P20, DOI 10.1002/ajmg.b.30374
   Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
   Shaltiel G, 2008, MOL PSYCHIATR, V13, P858, DOI 10.1038/mp.2008.20
   Shuang M, 2004, AM J MED GENET B, V131B, P48, DOI 10.1002/ajmg.b.30025
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Strutz-Seebohm N, 2006, CELL PHYSIOL BIOCHEM, V18, P287, DOI 10.1159/000097675
   Teffer K, 2012, PROG BRAIN RES, V195, P191, DOI 10.1016/B978-0-444-53860-4.00009-X
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   TREVES A, 1994, HIPPOCAMPUS, V4, P374, DOI 10.1002/hipo.450040319
   Voikar V, 2001, PHYSIOL BEHAV, V72, P271, DOI 10.1016/S0031-9384(00)00405-4
   von Heimendahl M, 2012, J NEUROSCI, V32, P2129, DOI 10.1523/JNEUROSCI.3812-11.2012
   Wassink TH, 2004, MENT RETARD DEV D R, V10, P272, DOI 10.1002/mrdd.20041
   Wolfer DP, 1997, BRAIN RES, V771, P1, DOI 10.1016/S0006-8993(97)00673-2
   Woo TUW, 2007, SCHIZOPHR RES, V96, P46, DOI 10.1016/j.schres.2007.06.023
   Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
   Yassa MA, 2011, P NATL ACAD SCI USA, V108, P8873, DOI 10.1073/pnas.1101567108
   Yassa MA, 2011, TRENDS NEUROSCI, V34, P515, DOI 10.1016/j.tins.2011.06.006
NR 53
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1050-9631
EI 1098-1063
J9 HIPPOCAMPUS
JI Hippocampus
PD SEP
PY 2014
VL 24
IS 9
BP 1059
EP 1069
DI 10.1002/hipo.22290
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AO3OW
UT WOS:000341243000002
PM 24753134
ER

PT J
AU Chiocchetti, AG
   Bour, HS
   Freitag, CM
AF Chiocchetti, Andreas G.
   Bour, Hanna S.
   Freitag, Christine M.
TI Glutamatergic candidate genes in autism spectrum disorder: an overview
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE ASD; Genetic studies; Glutamtergic pathway; Review
ID PERVASIVE DEVELOPMENTAL DISORDERS; DE-NOVO MUTATIONS; FAMILY-BASED
   ASSOCIATION; COPY-NUMBER VARIATION; FRAGILE-X-SYNDROME;
   GENOTYPE-PHENOTYPE CORRELATIONS; RUBINSTEIN-TAYBI SYNDROME; LONG-TERM
   POTENTIATION; GENOME-WIDE LINKAGE; MENTAL-RETARDATION
AB Autism spectrum disorders (ASD) are neurodevelopmental disorders with early onset in childhood. Most of the risk for ASD can be explained by genetic variants that act in interaction with biological environmental risk factors. However, the architecture of the genetic components is still unclear. Genetic studies and subsequent systems biological approaches described converging functional effects of identified genes towards pathways relevant for neuronal signalling. Mouse models suggest an aberrant synaptic plasticity at the neuropathological level, which is believed to be conferred by dysregulation of long-term potentiation or depression of neuronal connections. A central pathway regulating these mechanisms is glutamatergic signalling. Here, we hypothesized that susceptibility genes for ASD are enriched for components of this pathway. To further understand the impact of ASD risk genes on the glutamatergic pathway, we performed a systematic review using the literature database "pubmed" and the "AutismKB" knowledgebase. We provide an overview of the glutamatergic system in typical brain function and development, and summarize findings from linkage, association, copy number variants, and sequencing studies in ASD to provide a comprehensive picture of the glutamatergic landscape of ASD genetics. Genetic variants associated with ASD were enriched in glutamatergic pathways, affecting receptor signalling, metabolism and transport. Furthermore, in genetically modified mouse models for ASD, pharmacological compounds acting on ionotropic or metabotropic receptor activity are able to rescue ASD reminscent phenotypes. We conclude that glutamatergic genetic risk factors for ASD show a complex pattern and further studies are needed to fully understand its mechanisms, before translation of findings into clinical applications and individualized treatment approaches will be possible.
C1 [Chiocchetti, Andreas G.; Bour, Hanna S.; Freitag, Christine M.] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
RP Chiocchetti, AG (reprint author), Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, Deutschordenstr 50, D-60528 Frankfurt, Germany.
EM andreas.chiocchetti@kgu.de
CR Allen-Brady K, 2009, MOL PSYCHIATR, V14, P590, DOI 10.1038/mp.2008.14
   Allen-Brady K, 2010, MOL PSYCHIATR, V15, P1006, DOI 10.1038/mp.2009.42
   AMBROSINI A, 1995, MOL PHARMACOL, V47, P1057
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Anderson CM, 2000, GLIA, V32, P1
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Ascano M, 2012, NATURE, V492, P382, DOI 10.1038/nature11737
   Auranen M, 2002, AM J HUM GENET, V71, P777, DOI 10.1086/342720
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Balciuniene J, 2007, AM J HUM GENET, V80, P938, DOI 10.1086/513607
   Barbado M, 2009, BBA-MOL CELL RES, V1793, P1096, DOI 10.1016/j.bbamcr.2009.02.004
   Barnby G, 2005, AM J HUM GENET, V76, P950, DOI 10.1086/430454
   Bartsch O, 2010, AM J MED GENET A, V152A, P181, DOI 10.1002/ajmg.a.33153
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Bassuk AG, 2013, AM J MED GENET A, V161A, P1722, DOI 10.1002/ajmg.a.35946
   Bateup HS, 2013, NEURON, V78, P510, DOI 10.1016/j.neuron.2013.03.017
   Bauer JW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067609
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bonati MT, 2005, AM J MED GENET A, V133A, P184, DOI 10.1002/ajmg.a.30503
   Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
   Bremer A, 2011, AM J MED GENET B, V156B, P115, DOI 10.1002/ajmg.b.31142
   BROSTROM CO, 1990, ANNU REV PHYSIOL, V52, P577
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Buxbaum JD, 2001, AM J HUM GENET, V68, P1514, DOI 10.1086/320588
   Buxbaum JD, 2004, MOL PSYCHIATR, V9, P144, DOI 10.1038/sj.mp.4001465
   Carlson GC, 2012, PHARMACOL BIOCHEM BE, V100, P850, DOI 10.1016/j.pbb.2011.02.003
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
   Chahrour M, 2008, SCIENCE, V320, P1224, DOI 10.1126/science.1153252
   Chao HT, 2007, NEURON, V56, P58, DOI 10.1016/j.neuron.2007.08.018
   Chen CP, 2010, EUR J MED GENET, V53, P329, DOI 10.1016/j.ejmg.2010.06.004
   Chen YZ, 2012, AM J MED GENET B, V159B, P61, DOI 10.1002/ajmg.b.32002
   Chiyonobu T, 2007, AM J MED GENET A, V143A, P1448, DOI 10.1002/ajmg.a.31798
   Chonchaiya W, 2012, HUM GENET, V131, P581, DOI 10.1007/s00439-011-1106-6
   Choudhury PR, 2012, PHARMACOL BIOCHEM BE, V100, P841, DOI 10.1016/j.pbb.2011.06.023
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
   Chu ZG, 2000, BRAIN RES, V879, P88, DOI 10.1016/S0006-8993(00)02752-9
   Chung BHY, 2011, EUR J MED GENET, V54, pE516, DOI 10.1016/j.ejmg.2011.05.008
   Clifford S, 2007, J AUTISM DEV DISORD, V37, P738, DOI 10.1007/s10803-006-0205-z
   Cusco I, 2009, HUM MOL GENET, V18, P1795, DOI 10.1093/hmg/ddp092
   Danbolt NC, 2001, PROG NEUROBIOL, V65, P1, DOI 10.1016/S0301-0082(00)00067-8
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   de Krom M, 2009, BIOL PSYCHIAT, V65, P625, DOI 10.1016/j.biopsych.2008.09.035
   de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Doherty James, 2002, Current Drug Targets - CNS and Neurological Disorders, V1, P251, DOI 10.2174/1568007023339355
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Duffney LJ, 2013, J NEUROSCI, V33, P15767, DOI 10.1523/JNEUROSCI.1175-13.2013
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Durand CM, 2012, MOL PSYCHIATR, V17, P71, DOI 10.1038/mp.2011.57
   Edens AC, 2011, DEV MED CHILD NEUROL, V53, P463, DOI 10.1111/j.1469-8749.2010.03909.x
   Endele S, 2010, NAT GENET, V42, P1021, DOI 10.1038/ng.677
   Erickson CA, 2007, PSYCHOPHARMACOLOGY, V191, P141, DOI 10.1007/s00213-006-0518-9
   Fatemi SH, 2008, PROG NEURO-PSYCHOPH, V32, P911, DOI 10.1016/j.pnpbp.2007.11.004
   Feyder M, 2010, AM J PSYCHIAT, V167, P1508, DOI 10.1176/appi.ajp.2010.10040484
   Finelli P, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.016311
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Freitag CM, 2012, Z KINDER JUG-PSYCH, V40, P139, DOI 10.1024/1422-4917/a000164
   Gai X, 2012, MOL PSYCHIATR, V17, P402, DOI 10.1038/mp.2011.10
   Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
   Goizet C, 2000, AM J MED GENET, V96, P839, DOI 10.1002/1096-8628(20001204)96:6<839::AID-AJMG29>3.0.CO;2-R
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Griswold AJ, 2012, HUM MOL GENET, V21, P3513, DOI 10.1093/hmg/dds164
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   HALL JG, 1990, AM J HUM GENET, V46, P857
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   HERAULT J, 1995, AM J MED GENET, V60, P276, DOI 10.1002/ajmg.1320600404
   HERAULT J, 1993, PSYCHIAT RES, V46, P261, DOI 10.1016/0165-1781(93)90094-W
   Hosenbocus Sheik, 2013, J Can Acad Child Adolesc Psychiatry, V22, P166
   Hosenbocus Sheik, 2013, J Can Acad Child Adolesc Psychiatry, V22, P55
   Huguet G, 2013, ANNU REV GENOM HUM G, V14
   Hussman JP, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-1
   Bailey A, 1998, HUM MOL GENET, V7, P571
   Palferman S, 2001, HUM MOL GENET, V10, P973
   Palferman S, 2001, AM J HUM GENET, V69, P570
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
   Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
   Javitt DC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002804
   Jiang XY, 2006, CANCER RES, V66, P5258, DOI 10.1158/0008-5472.CAN-05-4510
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   Johansson M, 2010, RES DEV DISABIL, V31, P9, DOI 10.1016/j.ridd.2009.07.011
   Kelleher RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035003
   Kelleher RJ, 2004, NEURON, V44, P59, DOI 10.1016/j.neuron.2004.09.013
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Keller K, 2003, AM J MED GENET A, V117A, P105, DOI 10.1002/ajmg.a.10042
   Kim SA, 2007, NEUROSCI RES, V58, P332, DOI 10.1016/j.neures.2007.03.002
   King BH, 2001, J AM ACAD CHILD PSY, V40, P658, DOI 10.1097/00004583-200106000-00010
   KLINK A, 1995, HUM MOL GENET, V4, P869, DOI 10.1093/hmg/4.5.869
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
   Kumar RA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004582
   Lamb JA, 2005, J MED GENET, V42, P132, DOI 10.1136/jmg.2004.025668
   Lauritsen MB, 2006, MOL PSYCHIATR, V11, P37, DOI 10.1038/sj.mp.4001754
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Lesch KP, 2013, EUR NEUROPSYCHOPHARM, V23, P479, DOI 10.1016/j.euroneuro.2012.07.013
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Li HD, 2011, NAT NEUROSCI, V14, P1001, DOI 10.1038/nn.2866
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Liu JJ, 2001, AM J HUM GENET, V69, P327, DOI 10.1086/321980
   Loat CS, 2008, GENES BRAIN BEHAV, V7, P754, DOI 10.1111/j.1601-183X.2008.00414.x
   Luscher C, 2010, NEURON, V65, P445, DOI 10.1016/j.neuron.2010.01.016
   Ma DQ, 2007, MOL PSYCHIATR, V12, P376, DOI 10.1038/sj.mp.4001927
   Mackenzie B, 2004, PFLUG ARCH EUR J PHY, V447, P784, DOI 10.1007/s00424-003-1117-9
   Malenka RC, 2004, NEURON, V44, P5, DOI 10.1016/j.neuron.2004.09.012
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McCauley JL, 2005, BMC MED GENET, V6, DOI 10.1186/1471-2350-6-1
   Mehta MV, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026077
   Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
   Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
   Moreno-Fuenmayor H, 1996, Invest Clin, V37, P113
   Mount RH, 2003, J AUTISM DEV DISORD, V33, P435, DOI 10.1023/A:1025066913283
   Myers RA, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001318
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nelson TH, 2012, BMC MED GENOMICS, V5, DOI 10.1186/1755-8794-5-56
   Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
   Newsholme P, 2003, CELL BIOCHEM FUNCT, V21, P1, DOI 10.1002/cbf.1003
   Nicoll RA, 2013, NEUROPHARMACOLOGY, V74, P18, DOI 10.1016/j.neuropharm.2013.02.010
   Niklasson L, 2002, DEV MED CHILD NEUROL, V44, P44, DOI 10.1017/S0012162201001645
   Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
   Nord AS, 2011, EUR J HUM GENET, V19, P727, DOI 10.1038/ejhg.2011.24
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Owley T, 2006, J CHILD ADOL PSYCHOP, V16, P517, DOI 10.1089/cap.2006.16.517
   Ozgen HM, 2009, CLIN GENET, V76, P348, DOI 10.1111/j.1399-0004.2009.01254.x
   Pacey LKK, 2011, MOL CELL NEUROSCI, V46, P563, DOI 10.1016/j.mcn.2010.12.005
   Papanikolaou K, 2006, J AUTISM DEV DISORD, V36, P705, DOI 10.1007/s10803-006-0104-3
   Pescucci C, 2003, CLIN GENET, V64, P497, DOI 10.1046/j.1399-0004.2003.00176.x
   Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Piton A, 2011, Mol Psychiatry, V16, P867, DOI 10.1038/mp.2010.54
   Poelmans G, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.48
   Prasad C, 2000, CLIN GENET, V57, P103, DOI 10.1034/j.1399-0004.2000.570203.x
   Prather P, 2004, J CHILD NEUROL, V19, P666
   Ramanathan S, 2004, BMC MED GENET, V16, P5
   Ramelli GP, 2008, DEV MED CHILD NEUROL, V50, P953, DOI 10.1111/j.1469-8749.2008.03048.x
   Raught B, 1999, INT J BIOCHEM CELL B, V31, P43, DOI 10.1016/S1357-2725(98)00131-9
   Raynaud F, 2013, J NEUROSCI, V33, P9699, DOI 10.1523/JNEUROSCI.2725-12.2013
   Rehnstrom K, 2009, AM J MED GENET B, V150B, P741, DOI 10.1002/ajmg.b.30882
   Risch N, 1999, AM J HUM GENET, V65, P493, DOI 10.1086/302497
   Roubertie A, 2001, BRAIN DEV-JPN, V23, P810, DOI 10.1016/S0387-7604(01)00258-3
   Sahoo T, 2005, AM J MED GENET A, V139A, P106, DOI 10.1002/ajmg.a.31000
   Sakamoto K, 2011, J NEUROCHEM, V116, P1, DOI 10.1111/j.1471-4159.2010.07080.x
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sanlaville D, 2006, J MED GENET, V43, P211, DOI 10.1136/jmg.2005.036160
   Sarbassov DD, 2004, CURR BIOL, V14, P1296
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Sauter S, 2003, AM J MED GENET A, V120A, P533, DOI 10.1002/ajmg.a.20089
   Schellenberg GD, 2006, MOL PSYCHIATR, V11, P1049, DOI 10.1038/sj.mp.4001874
   Schorry EK, 2008, AM J MED GENET A, V146A, P2512, DOI 10.1002/ajmg.a.32424
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Serajee FJ, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.4.e42
   Serajee FJ, 2009, J CHILD NEUROL, V24, P1258, DOI 10.1177/0883073809333530
   Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
   Shigemoto R, 1997, J NEUROSCI, V17, P7503
   Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
   Shuang M, 2004, AM J MED GENET B, V131B, P48, DOI 10.1002/ajmg.b.30025
   Sihra TS, 2013, NEUROSCIENTIST, V20, P29
   Silva AE, 2002, ARQ NEURO-PSIQUIAT, V60, P290, DOI 10.1590/S0004-282X2002000200021
   Silvestrin RB, 2013, BRAIN RES, V1495, P52, DOI 10.1016/j.brainres.2012.11.048
   Soysal Y, 2011, AM J MED GENET A, V155A, P1745, DOI 10.1002/ajmg.a.34101
   Spence SJ, 2006, AM J MED GENET B, V141B, P591, DOI 10.1002/ajmg.b.30329
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Takayasu Y, 2009, ACTA PHYSIOL, V197, P1, DOI 10.1111/j.1748-1716.2009.02019.x
   Thomas AM, 2012, PSYCHOPHARMACOLOGY, V219, P47, DOI 10.1007/s00213-011-2375-4
   Thomas NS, 1999, HUM GENET, V104, P43, DOI 10.1007/s004390050908
   Tidyman WE, 2009, CURR OPIN GENET DEV, V19, P230, DOI 10.1016/j.gde.2009.04.001
   Toma C, 2013, MOL PSYCHIAT
   Urraca N, 2013, AUTISM RES, V6, P268, DOI 10.1002/aur.1284
   van der Zwaag B, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005324
   van der Zwaag B, 2010, AM J MED GENET B, V153B, P960, DOI 10.1002/ajmg.b.31055
   Vanhoutte P, 1999, MOL CELL BIOL, V19, P136
   Verpelli C, 2011, J BIOL CHEM, V286, P34839, DOI 10.1074/jbc.M111.258384
   Vincent JB, 2004, AM J MED GENET B, V125B, P54, DOI 10.1002/ajmg.b.20088
   Waltereit R, 2003, MOL NEUROBIOL, V27, P99, DOI 10.1385/MN:27:1:99
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wassink TH, 2001, PSYCHIATR GENET, V11, P57, DOI 10.1097/00041444-200106000-00001
   Weinstein LS, 2002, ANN NY ACAD SCI, V968, P173
   Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Wolpert CM, 2001, AM J MED GENET, V105, P222, DOI 10.1002/ajmg.1258
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Wong M, 2003, ANN NEUROL, V54, P251, DOI 10.1002/ana.10648
   Wu Y, 2007, P NATL ACAD SCI USA, V104, P18163, DOI 10.1073/pnas.0708699104
   Xu L, 2011, NUCLEIC ACIDS RES, V40, pD1016
   Ylisaukko-oja T, 2006, ANN NEUROL, V59, P145, DOI 10.1002/ana.20722
   Yonan AL, 2003, AM J HUM GENET, V73, P886, DOI 10.1086/378778
   Yoo HJ, 2012, NEUROSCI LETT, V512, P89, DOI 10.1016/j.neulet.2012.01.061
   Yu CE, 2002, AM J HUM GENET, V71, P100, DOI 10.1086/341291
   Zappella M, 2003, AM J MED GENET B, V119B, P102, DOI 10.1002/ajmg.b.10070
   Zhong XF, 2012, J NEUROSCI, V32, P12841, DOI 10.1523/JNEUROSCI.2784-12.2012
NR 197
TC 0
Z9 0
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1081
EP 1106
DI 10.1007/s00702-014-1161-y
PG 26
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400002
PM 24493018
ER

PT J
AU Waltes, R
   Gfesser, J
   Haslinger, D
   Schneider-Momm, K
   Biscaldi, M
   Voran, A
   Freitag, CM
   Chiocchetti, AG
AF Waltes, Regina
   Gfesser, Johannes
   Haslinger, Denise
   Schneider-Momm, Katja
   Biscaldi, Monica
   Voran, Anette
   Freitag, Christine M.
   Chiocchetti, Andreas G.
TI Common EIF4E variants modulate risk for autism spectrum disorders in the
   high-functioning range
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Association analysis; Transmission disequilibrium testing; Common
   variant; High-functioning autism; Repetitive behaviour
ID FRAGILE-X-SYNDROME; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC
   INTERVIEW; GENETIC-VARIANTS; GERMAN FORM; TRANSLATION; ASSOCIATION;
   RELIABILITY; BEHAVIORS; MUTATIONS
AB The genetic architecture of Autism Spectrum Disorders (ASD) is complex. Common genetic variation has especially been related to high-functioning ASD. In addition, some studies favoured analysis of strictly diagnosed autism individuals, which resulted in more robust findings than the combined analysis of all spectrum individuals. Functional variants modulating EIF4E expression have previously been indicated as risk factors for ASD. Pharmacological modulation of glutamate receptors which regulate EIF4E activity resulted in reduced repetitive behaviours in human and animal studies. Based on these findings, we tested common EIF4E variants for association with overall ASD, with strict autism and with the strict high-functioning autism (strict HFA) subgroup, and their effect on repetitive and/or stereotypic behaviour. We observed over-transmission of rs13109000G in the strict HFA and the strict autism cohort but not in the larger ASD cohort. We report protective effects for the minor allele of rs4699369T on stereotyped and ritualized behaviour in the overall ASD cohort, the strict autism but not in the strict HFA group. In addition, a protective role for rs4699369T and a risk effect of rs12498533G on hand and finger mannerisms was observed. These results need to be replicated in larger ASD and strict autism samples. The predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.
C1 [Waltes, Regina; Gfesser, Johannes; Haslinger, Denise; Freitag, Christine M.; Chiocchetti, Andreas G.] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat, D-60528 Frankfurt, Germany.
   [Schneider-Momm, Katja; Biscaldi, Monica] Univ Hosp Freiburg, Dept Child & Adolescent Psychiat, D-79104 Freiburg, Germany.
   [Voran, Anette] Saarland Univ Hosp, Dept Child & Adolescent Psychiat, D-66421 Homburg, Germany.
RP Chiocchetti, AG (reprint author), Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat, D-60528 Frankfurt, Germany.
EM andreas.chiocchetti@kgu.de
FU Saarland University [T6 03 10 00-45]; European Union; Bundesministerium
   fur Bildung und Forschung (ERA-NET NEURON project)
   [EUHF-AUTISM-01EW1105]; Landes-Offensive zur Entwicklung
   wissenschaftlich okonomischer Exzellenz (LOEWE): Neuronal Coordination
   Research Focus Frankfurt (NeFF)
FX We thank all patients and their families for taking part in this study.
   In addition, we thoroughly thank Silvia Lindlar and Hiacynta Jelen for
   excellent technical assistance and Heiko Zerlaut and Rusico Weber for
   database management. This work was supported by the Saarland University
   (T6 03 10 00-45 to C. M. F.), the European Union and the
   Bundesministerium fur Bildung und Forschung (ERA-NET NEURON project:
   EUHF-AUTISM-01EW1105 to C. M. F.); and the Landes-Offensive zur
   Entwicklung wissenschaftlich okonomischer Exzellenz (LOEWE): Neuronal
   Coordination Research Focus Frankfurt (NeFF to C.M.F.).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
   Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bolte S, 2004, Z KINDER JUG-PSYCH, V32, P45, DOI 10.1024/1422-4917.32.1.45
   Bruno JL, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-20
   Chiocchetti A.G., 2014, J NEURAL TRANSM
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Dudbridge F, 2008, HUM HERED, V66, P87, DOI 10.1159/000119108
   Durand CM, 2012, MOL PSYCHIATR, V17, P71, DOI 10.1038/mp.2011.57
   Ehninger D, 2013, NEUROPHARMACOLOGY, V68, P97, DOI 10.1016/j.neuropharm.2012.05.015
   Erickson CA, 2007, PSYCHOPHARMACOLOGY, V191, P141, DOI 10.1007/s00213-006-0518-9
   Estes A, 2011, AUTISM RES, V4, P212, DOI 10.1002/aur.193
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   Gauderman WJ, 2006, QUANTO 1 1 COMPUTER
   Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
   Goodfellow IG, 2008, INT J BIOCHEM CELL B, V40, P2675, DOI 10.1016/j.biocel.2007.10.023
   Gutierrez RC, 2009, NEUROSCIENCE, V162, P208, DOI 10.1016/j.neuroscience.2009.04.062
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Jiao Y, 2011, ADV MED SCI-POLAND, V56, P334, DOI 10.2478/v10039-011-0042-y
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Klauck SM, 1997, HUM MOL GENET, V6, P2233, DOI 10.1093/hmg/6.13.2233
   Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   McCarthy MI, 2008, NAT REV GENET, V9, P356, DOI 10.1038/nrg2344
   Mehta MV, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026077
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Munesue T, 2010, NEUROSCI RES, V67, P181, DOI 10.1016/j.neures.2010.03.004
   Napoli I, 2008, CELL, V134, P1042, DOI 10.1016/j.cell.2008.07.031
   Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
   Owley T, 2006, J CHILD ADOL PSYCHOP, V16, P517, DOI 10.1089/cap.2006.16.517
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Poustka F, 1996, PSYCHOPATHOLOGY, V29, P145
   Salyakina D, 2010, AUTISM RES, V3, P303, DOI 10.1002/aur.158
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Santini E, 2013, NATURE, V493, P411, DOI 10.1038/nature11782
   Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
   Thomas AM, 2012, PSYCHOPHARMACOLOGY, V219, P47, DOI 10.1007/s00213-011-2375-4
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   Vieland VJ, 2011, J NEURODEV DISORD, V3, P113, DOI 10.1007/s11689-011-9072-9
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   Wermter AK, 2010, AM J MED GENET B, V153B, P629, DOI 10.1002/ajmg.b.31032
   WHO, 1993, ICD 10 CLASS MENT BE
   Ylisaukko-oja T, 2006, ANN NEUROL, V59, P145, DOI 10.1002/ana.20722
   Zoghbi H.Y., 2012, COLD SPRING HARB PER, V4, P4, DOI DOI 10.1101/CSHPERSPECT.A009886
NR 51
TC 1
Z9 1
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1107
EP 1116
DI 10.1007/s00702-014-1230-2
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400003
PM 24818597
ER

PT J
AU Taurines, R
   Segura, M
   Schecklmann, M
   Albantakis, L
   Grunblatt, E
   Walitza, S
   Jans, T
   Lyttwin, B
   Haberhausen, M
   Theisen, FM
   Martin, B
   Briegel, W
   Thome, J
   Schwenck, C
   Romanos, M
   Gerlach, M
AF Taurines, Regina
   Segura, Monica
   Schecklmann, Martin
   Albantakis, Laura
   Gruenblatt, Edna
   Walitza, Susanne
   Jans, Thomas
   Lyttwin, Benjamin
   Haberhausen, Michael
   Theisen, Frank M.
   Martin, Berthold
   Briegel, Wolfgang
   Thome, Johannes
   Schwenck, Christina
   Romanos, Marcel
   Gerlach, Manfred
TI Altered peripheral BDNF mRNA expression and BDNF protein concentrations
   in blood of children and adolescents with autism spectrum disorder
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Autism spectrum disorder (ASD); Brain-derived neurotrophic factor
   (BDNF); ADHD; Neurodevelopmental disorders; Peripheral expression
ID NEUROTROPHIC FACTOR BDNF; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   DEFICIT-HYPERACTIVITY DISORDER; GEL-BASED MICROARRAY;
   MENTAL-RETARDATION; EXECUTIVE DYSFUNCTION; DEPRESSED-PATIENTS; HUMAN
   PLATELETS; WORKING-MEMORY; SERUM-LEVELS
AB Findings from molecular genetic studies and analyses of postmortem and peripheral tissue led to the hypothesis that neurotrophins-as crucial moderators of neuroplasticity-impact on the pathophysiology of autism spectrum disorder (ASD). The study projects aimed to complement former results on the role of brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family with fundamental impact on brain development and function. The purpose of this work was to investigate peripheral BDNF mRNA expression and BDNF protein concentrations in ASD as potential surrogates for the effects observed in the central nervous system. In a BDNF protein quantification study, serum concentrations were analyzed using Enzyme-Linked Immunosorbent Assays in 24 male patients with ASD, all with an IQ > 70 (age 13.9 +/- A 3.0 years) and 20 age- and gender-matched healthy control subjects (age 14.4 +/- A 2.1 years; p = 0.522). In a further independent project, a BDNF mRNA expression analysis, mRNA levels from total blood were assessed by quantitative real-time polymerase chain reaction in a sample of 16 male ASD patients (age 10.8 +/- A 2.2), 15 age- and gender-matched healthy controls (age 12.1 +/- A 2.2) and 15 patients with attention deficit hyperactivity disorder as a clinical control group (age 11.8 +/- A 2.2; p = 0.207). In the protein quantification project, significantly decreased BDNF serum concentrations were found in ASD cases compared to healthy control children (t = -2.123, df = 42, p < 0.05). Analysis of covariance (ANCOVA) revealed this result in accordance with significant reductions in BDNF mRNA expression in ASD, observed in the mRNA expression study (F = 3.65; df = 2.43; p < 0.05); neither age nor IQ confounded the result, as indicated by ANCOVA (F = 3.961; df = 2.41; p < 0.05, eta (2) = 0.162). Our study projects supported the notion that neurotrophins are involved in the pathophysiology of ASD. Further studies may eventually contribute to the identification of distinct peripheral mRNA expression and protein concentration patterns possibly supporting diagnostic and therapeutic processes.
C1 [Taurines, Regina; Albantakis, Laura; Jans, Thomas; Lyttwin, Benjamin; Martin, Berthold; Romanos, Marcel; Gerlach, Manfred] Univ Wurzburg, Dept Child & Adolescent Psychiat, D-97080 Wurzburg, Germany.
   [Segura, Monica] Univ Int Catalunya, Fac Med & Hlth Sci, Barcelona, Spain.
   [Schecklmann, Martin] Univ Regensburg, Dept Psychiat & Psychotherapy, D-93053 Regensburg, Germany.
   [Gruenblatt, Edna; Walitza, Susanne] Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland.
   [Haberhausen, Michael] Univ Marburg, Dept Child & Adolescent Psychiat, Marburg, Germany.
   [Theisen, Frank M.] Herz Jesu Krankenhaus, Dept Child & Adolescent Psychiat, Fulda, Germany.
   [Briegel, Wolfgang] Leopoldina Hosp, Dept Child & Adolescent Psychiat, Schweinfurt, Germany.
   [Thome, Johannes] Univ Rostock, Dept Psychiat & Psychotherapy, D-18055 Rostock, Germany.
   [Thome, Johannes] Swansea Univ, Coll Med, Swansea, W Glam, Wales.
   [Schwenck, Christina] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat, Frankfurt, Germany.
RP Taurines, R (reprint author), Univ Wurzburg, Dept Child & Adolescent Psychiat, Fuechsleinstr 15, D-97080 Wurzburg, Germany.
EM taurines@kjp.uni-wuerzburg.de
FU Actelion; AstraZeneca; Bristol-Meyers Squibb; Ever Neuro Pharma;
   Janssen-Cilag; Lilly; Lundbeck; Medice Arzneimittel Putter; Merz
   Pharmaceuticals; Novartis Pharma; Pfizer Pharma; Roche; Servier; Shire;
   Swiss National Science Foundation (SNF); Deutsche
   Forschungsgemeinschaft; EU FP7; HSM Hochspezialisierte Medizin of the
   Kanton Zurich, Switzerland
FX J. T. has obtained financial support (e. g. lecture honoraria, grants
   for research projects and scientific meetings, advisory-board
   membership) from Actelion, AstraZeneca, Bristol-Meyers Squibb, Ever
   Neuro Pharma, Janssen-Cilag, Lilly, Lundbeck, Medice Arzneimittel
   Putter, Merz Pharmaceuticals, Novartis Pharma, Pfizer Pharma, Roche,
   Servier, Shire. Some of these companies manufacture drugs used in the
   treatment of ADHD and ASD. S. W. has received lecture honoraria from
   Janssen Cilag, AstraZeneca and Eli Lilly in the last 5 years. Her work
   was partially supported in the last 5 years by the Swiss National
   Science Foundation (SNF), Deutsche Forschungsgemeinschaft, EU FP7, HSM
   Hochspezialisierte Medizin of the Kanton Zurich, Switzerland. All other
   authors have no competing interests.
CR ACHENBACH TM, 1981, MONOGR SOC RES CHILD, V46, P1, DOI 10.2307/1165983
   Al-Ayadhi LY, 2012, NEUROCHEM RES, V37, P394, DOI 10.1007/s11064-011-0624-x
   Allen M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055718
   Alleva E, 2009, NEUROSCI BIOBEHAV R, V33, P525, DOI 10.1016/j.neubiorev.2008.09.004
   ALTAR CA, 1994, EXP NEUROL, V130, P31, DOI 10.1006/exnr.1994.1182
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   [Anonymous], ROCHE DIAGNOSTICS CI
   Bachmann V, 2012, SLEEP, V35, P335, DOI 10.5665/sleep.1690
   Barendse EM, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-14
   Bekinschtein P, 2008, P NATL ACAD SCI USA, V105, P2711, DOI 10.1073/pnas.0711863105
   Boelte S, 2006, DIAGNOSTISCHES INTER
   Boelte S, 2006, FSK FRAGEBOGEN SOZIA
   Brambilla P, 2004, FUNCT NEUROL, V19, P9
   Braun A, 1999, AM J RESP CELL MOL, V21, P537
   Castellanos FX, 2006, TRENDS COGN SCI, V10, P117, DOI 10.1016/j.tics.2006.01.011
   Cattell R., 1997, GRUNDINTELLIGENZTEST
   Cattell RB, 1949, HANDBOOK
   Chen B, 2001, BIOL PSYCHIAT, V50, P260, DOI 10.1016/S0006-3223(01)01083-6
   Cheng L, 2009, INT J MOL SCI, V10, P2487, DOI 10.3390/ijms10062487
   Cheng L, 2009, J BIOMED NANOTECHNOL, V5, P542, DOI 10.1166/jbn.2009.1058
   Connolly AM, 2006, BIOL PSYCHIAT, V59, P354, DOI 10.1016/j.biopsych.2005.07.004
   Corominas-Roso M, 2013, INT J NEUROPSYCHOPH, V30, P1, DOI DOI 10.1017/S1461145712001629
   Correia CT, 2010, GENES BRAIN BEHAV, V9, P841, DOI 10.1111/j.1601-183X.2010.00627.x
   Croen LA, 2008, AUTISM RES, V1, P130, DOI 10.1002/aur.14
   Dopfner M., 1994, KINDH ENTWICKL, V3, P54
   Dopfner M., 2008, DISYPS 2 DIAGNOSTIK
   D'Sa C, 2002, BIPOLAR DISORD, V4, P183, DOI 10.1034/j.1399-5618.2002.01203.x
   Dwivedi Y, 2009, NEUROPSYCH DIS TREAT, V5, P433
   Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
   Elfving B, 2010, J NEUROSCI METH, V187, P73, DOI 10.1016/j.jneumeth.2009.12.017
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   Freitag CM, 2012, Z KINDER JUG-PSYCH, V40, P139, DOI 10.1024/1422-4917/a000164
   Fujimura H, 2002, THROMB HAEMOSTASIS, V87, P728
   Fumagalli F, 2003, J NEUROSCI RES, V72, P622, DOI 10.1002/jnr.10609
   Gadow KD, 2009, J AUTISM DEV DISORD, V39, P1542, DOI 10.1007/s10803-009-0794-4
   Geier DA, 2007, NEUROENDOCRINOL LETT, V28, P565
   Geier DA, 2006, HORM RES, V66, P182, DOI 10.1159/000094467
   Gielen A, 2003, SCAND J IMMUNOL, V57, P493, DOI 10.1046/j.1365-3083.2003.01260.x
   Hammonds MD, 2009, BASIC CLIN PHARMACOL, V105, P113, DOI 10.1111/j.1742-7843.2009.00416.x
   Hashimoto K, 2006, PROG NEURO-PSYCHOPH, V30, P1529, DOI 10.1016/j.pnpbp.2006.06.018
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hill RA, 2012, J NEUROENDOCRINOL, V24, P774, DOI 10.1111/j.1365-2826.2012.02277.x
   Hünnerkopf Regina, 2007, Neuropsychopharmacology, V32, P2552, DOI 10.1038/sj.npp.1301383
   Ito W, 2011, GENES BRAIN BEHAV, V10, P365, DOI 10.1111/j.1601-183X.2010.00676.x
   Iughetti L, 2011, NEUROPEPTIDES, V45, P205, DOI 10.1016/j.npep.2011.02.002
   Karege F, 2002, NEUROSCI LETT, V328, P261, DOI 10.1016/S0304-3940(02)00529-3
   Karege F, 2005, BIOL PSYCHIAT, V57, P1068, DOI 10.1016/j.biopsych.2005.01.008
   Katoh-Semba R, 2007, INT J DEV NEUROSCI, V25, P367, DOI 10.1016/j.ijdevneu.2007.07.002
   Kaufman A. S., 2004, KAUFMAN ASSESSMENT B
   Kernie SG, 2000, EMBO J, V19, P1290, DOI 10.1093/emboj/19.6.1290
   Kerschensteiner M, 1999, J EXP MED, V189, P865, DOI 10.1084/jem.189.5.865
   Klein AB, 2011, INT J NEUROPSYCHOPH, V14, P347, DOI 10.1017/S1461145710000738
   Kotagal S, 2012, PEDIATR NEUROL, V47, P242, DOI 10.1016/j.pediatrneurol.2012.05.007
   Lai MC, 2014, LANCET, V383, P896, DOI 10.1016/S0140-6736(13)61539-1
   Lecendreux Michel, 2007, Expert Rev Neurother, V7, P1799, DOI 10.1586/14737175.7.12.1799
   Lommatzsch M, 2005, NEUROBIOL AGING, V26, P115, DOI 10.1016/j.neurobiolaging.2004.03.002
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mansour M, 2010, CURR PSYCHIAT, V17, P23
   Martinowich K, 2007, NAT NEUROSCI, V10, P1089, DOI 10.1038/nn1971
   Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
   Melchers P, 2009, KAUFMANN ASSESSMENT, V8
   Meredith GE, 2002, BRAIN RES, V949, P218, DOI 10.1016/S0006-8993(02)03160-8
   Miyazaki K, 2004, BRAIN DEV-JPN, V26, P292, DOI 10.1016/S0387-7604(03)00168-2
   Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
   Nishimura K, 2007, BIOCHEM BIOPH RES CO, V356, P200, DOI 10.1016/j.bbrc.2007.02.135
   Noterdaeme MA, 2010, Z KINDER JUG-PSYCH, V38, P257, DOI 10.1024/1422-4917/a000045
   Pan WH, 1998, NEUROPHARMACOLOGY, V37, P1553, DOI 10.1016/S0028-3908(98)00141-5
   Pandey GN, 2010, PROG NEURO-PSYCHOPH, V34, P645, DOI 10.1016/j.pnpbp.2010.03.003
   Park SW, 2009, EUR NEUROPSYCHOPHARM, V19, P356, DOI 10.1016/j.euroneuro.2008.12.012
   Petermann F, 2007, HAMBURG WECHSEL INTE
   Polleux F, 2004, MENT RETARD DEV D R, V10, P303, DOI 10.1002/mrdd.20044
   Poo MM, 2001, NAT REV NEUROSCI, V2, P24, DOI 10.1038/35049004
   Richter-Schmidinger T, 2011, J NEURAL TRANSM, V118, P249, DOI 10.1007/s00702-010-0539-8
   Rohlf H, 2012, J NEURAL TRANSM, V119, P95, DOI 10.1007/s00702-011-0660-3
   Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
   Ruehl D, 2004, ADOS DIAGNOSTISCHE B
   Ruta L, 2011, PSYCHONEUROENDOCRINO, V36, P1154, DOI 10.1016/j.psyneuen.2011.02.007
   Rutter M., 2003, SOCIAL COMMUNICATION
   Scassellati C, 2013, EUR CHILD ADOLESC PS
   Schmitz C, 2008, NEUROPATH APPL NEURO, V34, P4, DOI 10.1111/j.1365-2990.2007.00872.x
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shim SH, 2008, PROG NEURO-PSYCHOPH, V32, P1824, DOI 10.1016/j.pnpbp.2008.08.005
   Shimizu E, 2003, BIOL PSYCHIAT, V54, P70, DOI 10.1016/S0006-3223(03)00181-1
   Siuciak JA, 1996, BRAIN RES, V710, P11, DOI 10.1016/0006-8993(95)01289-3
   Takagishi H, 2010, NEUROENDOCRINOL LETT, V31, P837
   Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
   Taurines Regina, 2010, Atten Defic Hyperact Disord, V2, P267, DOI 10.1007/s12402-010-0040-0
   Terracciano A, 2010, NEUROPSYCHOPHARMACOL, V35, P1083, DOI 10.1038/npp.2009.213
   Tewes U., 1999, HAMBURG WECHSLER INT
   Tsai SJ, 2008, PHARMACOGENOMICS, V9, P1353, DOI 10.2217/14622416.9.9.1353
   Wechsler D, 1949, WECHSLER INTELLIGENC
   Weiss R. H., 1998, GRUNDINTELLIGENZTEST
   Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
   Wong J, 2010, NEUROSCIENCE, V169, P1071, DOI 10.1016/j.neuroscience.2010.05.037
   Yamada K, 2002, LIFE SCI, V70, P735, DOI 10.1016/S0024-3205(01)01461-8
   Zheng Fei, 2012, Int J Physiol Pathophysiol Pharmacol, V4, P188
NR 98
TC 3
Z9 3
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1117
EP 1128
DI 10.1007/s00702-014-1162-x
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400004
PM 24500031
ER

PT J
AU Luckhardt, C
   Jarczok, TA
   Bender, S
AF Luckhardt, C.
   Jarczok, T. A.
   Bender, S.
TI Elucidating the neurophysiological underpinnings of autism spectrum
   disorder: new developments
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Autism; Visual event-related potential; Mirror neuron; Connectivity;
   Transcranial magnetic stimulation; Excitation; Inhibition
ID TRANSCRANIAL MAGNETIC STIMULATION; EVENT-RELATED POTENTIALS;
   FRAGILE-X-SYNDROME; MIRROR NEURON DYSFUNCTION; VISUAL-EVOKED POTENTIALS;
   HIGH-FUNCTIONING AUTISM; EEG MU-RHYTHM; FACE PERCEPTION; YOUNG-CHILDREN;
   INTERSTIMULUS VARIANCE
AB The study of neurophysiological approaches together with rare and common risk factors for Autism Spectrum Disorder (ASD) allows elucidating the specific underlying neurobiology of ASD. Whereas most neurophysiologically based research in ASD to date has focussed on case-control differences based on the DSM- or ICD-based categorical ASD diagnosis, more recent studies have aimed at studying genetically and/or neurophysiologically defined homogeneous ASD subgroups for specific neuronal biomarkers. This review addresses the neurophysiological investigation of ASD by evoked and event-related potentials, by EEG/MEG connectivity measures such as coherence, and transcranial magnetic stimulation. As an example of classical neurophysiological studies in ASD, we report event-related potential studies which have illustrated which brain areas and processing stages are affected in the visual perception of socially relevant stimuli. However, a paradigm shift has taken place in recent years focussing on how these findings can be tracked down to basic neuronal functions such as deficits in cortico-cortical connectivity and the interaction between brain areas. Disconnectivity, for example, can again be related to genetically induced shifts in the excitation/inhibition balance. Genetic causes of ASD may be grouped by their effects on the brain's system level to identify ASD subgroups which respond differentially to therapeutic interventions.
C1 [Luckhardt, C.; Jarczok, T. A.; Bender, S.] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat, D-60528 Frankfurt, Germany.
RP Luckhardt, C (reprint author), Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat, Deutschordenstr 50, D-60528 Frankfurt, Germany.
EM Christina.Luckhardt@kgu.de
FU German Research Foundation DFG (Deutsche Forschungsgemeinschaft)
   [FR2069/2-1]; LOEWE programme, Neuronal Coordination Research Focus
   Frankfurt (NeFF) [B1]
FX We would like to thank Dr. Susanne Raisig for proofreading our
   manuscript. This work was supported by grant FR2069/2-1 of the German
   Research Foundation DFG (Deutsche Forschungsgemeinschaft) to C. M. F.,
   and the LOEWE programme, Neuronal Coordination Research Focus Frankfurt
   (NeFF), project B1, to S.B. and C.M.F.
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Allison T, 1999, CEREB CORTEX, V9, P415, DOI 10.1093/cercor/9.5.415
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Ameis SH, 2012, FRONT PSYCHIAT, V3
   Apicella F, 2013, BEHAV BRAIN RES, V251, P155, DOI 10.1016/j.bbr.2012.10.040
   Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
   Batty M, 2011, J EXP CHILD PSYCHOL, V109, P430, DOI 10.1016/j.jecp.2011.02.001
   Belmonte MK, 2006, NAT NEUROSCI, V9, P1221, DOI 10.1038/nn1765
   Bendat JS, 2000, MEASUREMENT SCI TECH, V11, P1825
   Bentin S, 1996, J COGNITIVE NEUROSCI, V8, P551, DOI 10.1162/jocn.1996.8.6.551
   Bentin S, 2007, NAT NEUROSCI, V10, P801, DOI 10.1038/nn0707-801
   Bentin S, 2000, COGN NEUROPSYCHOL, V17, P35, DOI 10.1080/026432900380472
   Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247]
   Bernier R, 2007, BRAIN COGNITION, V64, P228, DOI 10.1016/j.bandc.2007.03.004
   Bernier R, 2013, BRAIN COGNITION, V82, P69, DOI 10.1016/j.bandc.2013.02.008
   Blair RJR, 2002, NEUROPSYCHOLOGIA, V40, P108, DOI 10.1016/S0028-3932(01)00069-0
   Boersma M, 2011, HUM BRAIN MAPP, V32, P413, DOI 10.1002/hbm.21030
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820
   Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
   Buard I, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00742
   Burnette CP, 2011, J AUTISM DEV DISORD, V41, P1113, DOI 10.1007/s10803-010-1138-0
   Buzsaki G, 2004, SCIENCE, V304, P1926, DOI 10.1126/science.1099745
   CANTOR DS, 1986, J AUTISM DEV DISORD, V16, P169, DOI 10.1007/BF01531728
   Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
   Catarino A, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-1
   Churches O, 2012, NEUROREPORT, V23, P668, DOI 10.1097/WNR.0b013e3283556658
   Churches O, 2010, NEUROREPORT, V21, P399, DOI 10.1097/WNR.0b013e328334311b
   Clark V.P., 1995, HUMAN BRAIN MAPPING, V2, P170, DOI DOI 10.1002/HBM.460020306
   Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
   Collins AL, 2006, NEUROGENETICS, V7, P167, DOI 10.1007/s10048-006-0045-1
   Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Daskalakis ZJ, 2008, NEUROPSYCHOPHARMACOL, V33, P2860, DOI 10.1038/npp.2008.22
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x
   Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
   de Haan M, 2002, J COGNITIVE NEUROSCI, V14, P199
   de Haan M, 1999, DEV PSYCHOL, V35, P1113, DOI 10.1037/0012-1649.35.4.1113
   Di Martino A, 2013, MOL PSYCHIATR, V19, P659
   Di Russo F, 2002, HUM BRAIN MAPP, V15, P95, DOI 10.1002/hbm.10010
   Duffy FH, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-64
   Duffy FH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-175
   Eimer M, 2000, NEUROREPORT, V11, P2319, DOI 10.1097/00001756-200007140-00050
   Eimer M, 2000, COGNITIVE BRAIN RES, V10, P145, DOI 10.1016/S0926-6410(00)00038-0
   Eimer M, 2000, CLIN NEUROPHYSIOL, V111, P694, DOI 10.1016/S1388-2457(99)00285-0
   Enticott PG, 2010, DEV MED CHILD NEUROL, V52, pe179, DOI 10.1111/j.1469-8749.2010.03665.x
   Enticott PG, 2013, NEUROPHARMACOLOGY, V68, P202, DOI 10.1016/j.neuropharm.2012.06.017
   Everett JAC, 2013, NEUROPSYCHOL TRENDS, V13, P7
   Faja S, 2012, J AUTISM DEV DISORD, V42, P278, DOI 10.1007/s10803-011-1243-8
   Fan YT, 2010, J CHILD PSYCHOL PSYC, V51, P981, DOI 10.1111/j.1469-7610.2010.02269.x
   Fatemi SH, 2008, J AUTISM DEV DISORD, V39, P223
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   Frith C, 2004, LANCET NEUROL, V3, P577, DOI 10.1016/S1474-4422(04)00875-0
   Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
   Ganis G, 2012, NEUROIMAGE, V62, P1563, DOI 10.1016/j.neuroimage.2012.05.043
   Gilbert DL, 2011, NEUROLOGY, V76, P615, DOI 10.1212/WNL.0b013e31820c2ebd
   GRAY CM, 1989, NATURE, V338, P334, DOI 10.1038/338334a0
   Hagerman R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-12
   Halit H, 2003, NEUROIMAGE, V19, P1180, DOI 10.1016/S1053-8119(03)00076-4
   Hall SS, 2013, JAMA PSYCHIAT, V70, P1215, DOI 10.1001/jamapsychiatry.2013.247
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286
   Herrmann MJ, 2005, BRAIN TOPOGR, V18, P77, DOI 10.1007/s10548-005-0277-7
   Herrmann MJ, 2005, J NEURAL TRANSM, V112, P1073, DOI 10.1007/s00702-004-0250-8
   Hileman CM, 2011, DEV NEUROPSYCHOL, V36, P214, DOI 10.1080/87565641.2010.549870
   Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020
   Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
   Iacoboni M, 2005, CURR OPIN NEUROBIOL, V15, P632, DOI 10.1016/j.conb.2005.10.010
   Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
   Isler JR, 2010, CLIN NEUROPHYSIOL, V121, P2035, DOI 10.1016/j.clinph.2010.05.004
   Itier RJ, 2004, NEUROREPORT, V15, P1261, DOI 10.1097/01.wnr.0000127827.3576.d8
   Itier RJ, 2002, NEUROIMAGE, V15, P353, DOI 10.1006/nimg.2001.0982
   Jedlicka P, 2013, BRAIN STRUCT FUNCT, P1
   Jones W, 2009, J AM ACAD CHILD PSY, V48, P471, DOI 10.1097/CHI.0b013e31819f6c0d
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Khan S, 2013, P NATL ACAD SCI USA, V110, P3107, DOI 10.1073/pnas.1214533110
   Kikuchi M, 2013, NEUROIMAGE-CLIN, V2, P394, DOI 10.1016/j.nicl.2013.03.003
   Kleinhans NM, 2008, BRAIN RES, V1221, P115, DOI 10.1016/j.brainres.2008.04.080
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Kroger A, 2013, SOCIAL COGN AFFECT N
   KUJIRAI T, 1993, J PHYSIOL-LONDON, V471, P501
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Marshall PJ, 2002, CLIN NEUROPHYSIOL, V113, P1199, DOI 10.1016/S1388-2457(02)00163-3
   Mathewson KJ, 2012, CLIN NEUROPHYSIOL, V123, P1798, DOI 10.1016/j.clinph.2012.02.061
   Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
   Miniussi C, 2010, BRAIN TOPOGR, V22, P249, DOI 10.1007/s10548-009-0083-8
   Moll GH, 1999, NEUROSCI LETT, V272, P37, DOI 10.1016/S0304-3940(99)00575-3
   Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
   Oberman Lindsay, 2010, Front Synaptic Neurosci, V2, P26, DOI 10.3389/fnsyn.2010.00026
   Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   O'Connor K, 2005, BRAIN COGNITION, V59, P82, DOI 10.1016/j.bandc.2005.05.004
   Pfurtscheller G, 1997, INT J PSYCHOPHYSIOL, V26, P121, DOI 10.1016/S0167-8760(97)00760-5
   Ramachandran V. S., 2000, MIRROR NEURONS IMITA
   Raymaekers R, 2009, BRAIN RES, V1304, P113, DOI 10.1016/j.brainres.2009.09.068
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Rizzolatti G, 1998, TRENDS NEUROSCI, V21, P188, DOI 10.1016/S0166-2236(98)01260-0
   Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
   Rossion B, 1999, BIOL PSYCHOL, V50, P173, DOI 10.1016/S0301-0511(99)00013-7
   Rossion B, 2008, NEUROIMAGE, V39, P1959, DOI 10.1016/j.neuroimage.2007.10.011
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Rudvin I, 2000, VISUAL NEUROSCI, V17, P579, DOI 10.1017/S0952523800174085
   Schendan HE, 2013, PSYCHOPHYSIOLOGY, V50, P287, DOI 10.1111/psyp.12013
   Shigeto H, 1998, J NEUROL SCI, V156, P186, DOI 10.1016/S0022-510X(98)00026-4
   Srinivasan R, 2007, J NEUROSCI METH, V166, P41, DOI 10.1016/j.jneumeth.2007.06.026
   Stroganova TA, 2007, CLIN NEUROPHYSIOL, V118, P1842, DOI 10.1016/j.clinph.2007.05.005
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
   Taylor MJ, 2002, CLIN NEUROPHYSIOL, V113, P1903, DOI 10.1016/S1388-2457(02)00309-7
   Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
   Thierry G, 2007, NAT NEUROSCI
   Tost H, 2010, P NATL ACAD SCI USA, V107, P13936, DOI 10.1073/pnas.1003296107
   Tsiaras V, 2011, COMPUT BIOL MED, V41, P1166, DOI 10.1016/j.compbiomed.2011.04.004
   Wallace S, 2008, COGNITION EMOTION, V22, P1353, DOI 10.1080/02699930701782153
   Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x
   Webb SJ, 2011, CHILD DEV, V82, P1868, DOI 10.1111/j.1467-8624.2011.01656.x
   Webb SJ, 2012, SOC COGN AFFECT NEUR, V7, P578, DOI 10.1093/scan/nsp002
   Webb SJ, 2010, INT J PSYCHOPHYSIOL, V77, P106, DOI 10.1016/j.ijpsycho.2010.04.011
   Whittingstall K, 2007, HUM BRAIN MAPP, V28, P134, DOI 10.1002/hbm.20265
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002
   Wong TKW, 2008, EUR J NEUROSCI, V28, P407, DOI 10.1111/j.1460-9568.2008.06328.x
   Ziemann U, 2011, NEUROSCIENTIST, V17, P368, DOI 10.1177/1073858410390225
   Ziemann U, 2003, SUPPL CLIN NEUROPHYS, V56, P226
NR 130
TC 1
Z9 1
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1129
EP 1144
DI 10.1007/s00702-014-1265-4
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400005
PM 25059455
ER

PT J
AU Ambrosino, S
   Bos, DJ
   van Raalten, TR
   Kobussen, NA
   van Belle, J
   Oranje, B
   Durston, S
AF Ambrosino, S.
   Bos, D. J.
   van Raalten, T. R.
   Kobussen, N. A.
   van Belle, J.
   Oranje, B.
   Durston, S.
TI Functional connectivity during cognitive control in children with autism
   spectrum disorder: an independent component analysis
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE ASD; Functional connectivity; ICA; Cognitive control; Rigid behavior
ID INHIBITORY CONTROL; FMRI DATA; NETWORK CONNECTIVITY; REPETITIVE
   BEHAVIOR; DIAGNOSTIC INTERVIEW; RESPONSE-INHIBITION; WORKING-MEMORY;
   DEFAULT-MODE; MRI DATA; ACTIVATION
AB Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability.
C1 [Ambrosino, S.; Bos, D. J.; van Raalten, T. R.; Kobussen, N. A.; van Belle, J.; Oranje, B.; Durston, S.] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, NICHE Lab, Dept Psychiat, NL-3584 CX Utrecht, Netherlands.
RP Ambrosino, S (reprint author), Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, NICHE Lab, Dept Psychiat, HP A-01-126,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM S.AmbrosinodiBruttopilo-3@umcutrecht.nl
FU Hersenstichting Nederland [F2009(1)-17]
FX The authors would like to thank all the participants and their families
   of this study. We wish to thank Juliette Weusten for the assistance with
   subject recruitment and MRI assessment. This work was financially
   supported by the Hersenstichting Nederland, grant number F2009(1)-17.
CR Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
   Allen Elena A, 2011, Front Syst Neurosci, V5, P2, DOI 10.3389/fnsys.2011.00002
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Arbabshirani MR, 2013, HUM BRAIN MAPP, V34, P2959, DOI 10.1002/hbm.22118
   Balsters JH, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00207
   Balsters JH, 2013, NEUROBIOL AGING, V34, P2194, DOI 10.1016/j.neurobiolaging.2013.03.004
   Beckmann CF, 2005, PHILOS T ROY SOC B, V360, P1001, DOI 10.1098/rstb.2005.1634
   Beldzik E, 2013, NEUROIMAGE, V76, P304, DOI 10.1016/j.neuroimage.2013.03.014
   BELL AJ, 1995, NEURAL COMPUT, V7, P1129, DOI 10.1162/neco.1995.7.6.1129
   Bodfish J.W., 1999, REPETITIVE BEHAV SCA
   Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
   Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
   Calhoun VD, 2004, MAGN RESON IMAGING, V22, P1181, DOI 10.1016/j.mri.2004.09.004
   Calhoun VD, 2001, HUM BRAIN MAPP, V14, P140, DOI 10.1002/hbm.1048
   Calhoun VD, 2006, IEEE ENG MED BIOL, V25, P79, DOI 10.1109/MEMB.2006.1607672
   Calhoun VD, 2004, NEUROPSYCHOPHARMACOL, V29, P2097, DOI 10.1038/sj.npp.1300543
   Calhoun VD, 2002, HUM BRAIN MAPP, V16, P158, DOI 10.1002/hbm.10032
   Calhoun VD, 2009, NEUROIMAGE, V45, pS163, DOI 10.1016/j.neuroimage.2008.10.057
   Calhoun Vince D, 2011, Front Psychiatry, V2, P75, DOI 10.3389/fpsyt.2011.00075
   Calhoun VD, 2002, MAGNET RESON MED, V48, P180, DOI 10.1002/mrm.10202
   Chan RCK, 2008, ARCH CLIN NEUROPSYCH, V23, P201, DOI 10.1016/j.acn.2007.08.010
   Cole MW, 2007, NEUROIMAGE, V37, P343, DOI 10.1016/j.neuroimage.2007.03.071
   Congdon E, 2010, NEUROIMAGE, V53, P653, DOI 10.1016/j.neuroimage.2010.06.062
   Dichter Gabriel S, 2012, Dialogues Clin Neurosci, V14, P319
   Durston S, 2009, J AM ACAD CHILD PSY, V48, P206, DOI 10.1097/CHI.0b013e3181930673
   Durston S, 2003, BIOL PSYCHIAT, V53, P871, DOI 10.1016/S0006-3223(02)01904-2
   Durston S, 2006, NEUROPSYCHOLOGIA, V44, P2149, DOI 10.1016/j.neuropsychologia.2005.10.010
   Durston S, 2002, NEUROIMAGE, V16, P449, DOI 10.1006/nimg.2002.1074
   Durston S, 2006, DEVELOPMENTAL SCI, V9, P1, DOI 10.1111/j.1467-7687.2005.00454.x
   Durston S, 2002, DEVELOPMENTAL SCI, V5, pF9, DOI 10.1111/1467-7687.00235
   Erhardt EB, 2011, HUM BRAIN MAPP, V32, P2075, DOI 10.1002/hbm.21170
   Friston KJ, 1995, HUM BRAIN MAPP, V3, P165, DOI 10.1002/hbm.460030303
   Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Himberg J, 2004, NEUROIMAGE, V22, P1214, DOI 10.1016/j.neuroimage.2004.03.027
   Jafri MJ, 2008, NEUROIMAGE, V39, P1666, DOI 10.1016/j.neuroimage.2007.11.001
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
   Kim DI, 2009, HUM BRAIN MAPP, V30, P3795, DOI 10.1002/hbm.20807
   Langen M, 2011, NEUROSCI BIOBEHAV R, V35, P345, DOI 10.1016/j.neubiorev.2010.02.004
   Langen M, 2011, NEUROSCI BIOBEHAV R, V35, P356, DOI 10.1016/j.neubiorev.2010.02.005
   Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   McKeown MJ, 1998, HUM BRAIN MAPP, V6, P368, DOI 10.1002/(SICI)1097-0193(1998)6:5/6<368::AID-HBM7>3.0.CO;2-E
   McKeown MJ, 1998, P NATL ACAD SCI USA, V95, P803, DOI 10.1073/pnas.95.3.803
   Meda SA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007911
   Meda SA, 2009, HUM BRAIN MAPP, V30, P1257, DOI 10.1002/hbm.20591
   Menon V, 2010, BRAIN STRUCT FUNCT, V214, P655, DOI 10.1007/s00429-010-0262-0
   Mosconi MW, 2009, PSYCHOL MED, V39, P1559, DOI 10.1017/S0033291708004984
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
   Segall JM, 2012, FRONT NEUROINFORM, V6, DOI 10.3389/fninf.2012.00010
   Shaffer D, 2000, J AM ACAD CHILD PSY, V39, P28, DOI 10.1097/00004583-200001000-00014
   Sladky R, 2011, NEUROIMAGE, V58, P588, DOI 10.1016/j.neuroimage.2011.06.078
   Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
   Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001
   Supekar K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000157
   Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
   Wechsler D., 2005, WECHSLER INTELLIGENC, V4th
   Xu Jiansong, 2013, Front Neurosci, V7, P154, DOI 10.3389/fnins.2013.00154
   Xu JS, 2013, NEUROIMAGE, V79, P62, DOI 10.1016/j.neuroimage.2013.04.038
   Zhang S, 2012, HUM BRAIN MAPP, V33, P89, DOI 10.1002/hbm.21197
NR 63
TC 0
Z9 0
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1145
EP 1155
DI 10.1007/s00702-014-1237-8
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400006
PM 24845879
ER

PT J
AU Ecker, C
   Shahidiani, A
   Feng, Y
   Daly, E
   Murphy, C
   D'Almeida, V
   Deoni, S
   Williams, SC
   Gillan, N
   Gudbrandsen, M
   Wichers, R
   Andrews, D
   Van Hemert, L
   Murphy, DGM
AF Ecker, C.
   Shahidiani, A.
   Feng, Y.
   Daly, E.
   Murphy, C.
   D'Almeida, V.
   Deoni, S.
   Williams, S. C.
   Gillan, N.
   Gudbrandsen, M.
   Wichers, R.
   Andrews, D.
   Van Hemert, L.
   Murphy, D. G. M.
TI The effect of age, diagnosis, and their interaction on vertex-based
   measures of cortical thickness and surface area in autism spectrum
   disorder
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Autism; Neuroanatomy; Cortical thickness; Surface area; Neurodevelopment
ID COORDINATE SYSTEM; BRAIN OVERGROWTH; PROGENITOR CELLS; CEREBRAL-CORTEX;
   MRI; CHILDREN; ADOLESCENCE; ANATOMY; ADULTS; REPRESENTATION
AB Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition that is accompanied by an atypical development of brain maturation. So far, brain development has mainly been studied during early childhood in ASD, and using measures of total or lobular brain volume. However, cortical volumetric measures are a product of two distinct biological neuroanatomical features, cortical thickness, and surface area, which most likely also have different neurodevelopmental trajectories in ASD. Here, we therefore examined age-related differences in cortical thickness and surface area in a cross-sectional sample of 77 male individuals with ASD ranging from 7 to 25 years of age, and 77 male neurotypical controls matched for age and FSIQ. Surface-based measures were analyzed using a general linear model (GLM) including linear, quadratic, and cubic age terms, as well as their interactions with the main effect of group. When controlling for the effects of age, individuals with ASD had spatially distributed reductions in cortical thickness relative to controls, particularly in fronto-temporal regions, and also showed significantly reduced surface area in the prefrontal cortex and the anterior temporal lobe. We also observed significant group x age interactions for both measures. However, while cortical thickness was best predicted by a quadratic age term, the neurodevelopmental trajectory for measures of surface area was mostly linear. Our findings suggest that ASD is accompanied by age-related and region-specific reductions in cortical thickness and surface area during childhood and early adulthood. Thus, differences in the neurodevelopmental trajectory of maturation for both measures need to be taken into account when interpreting between-group differences overall.
C1 [Ecker, C.; Shahidiani, A.; Feng, Y.; Daly, E.; Murphy, C.; D'Almeida, V.; Gillan, N.; Gudbrandsen, M.; Wichers, R.; Andrews, D.; Murphy, D. G. M.] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England.
   [Ecker, C.; Shahidiani, A.; Feng, Y.; Daly, E.; Murphy, C.; D'Almeida, V.; Gillan, N.; Gudbrandsen, M.; Wichers, R.; Andrews, D.; Murphy, D. G. M.] Kings Coll London, Inst Psychiat, Sackler Inst Translat Neurodev Sci, London SE5 8AF, England.
   [Deoni, S.] Brown Univ, Sch Engn, Adv Baby Imaging Lab, Providence, RI 02912 USA.
   [Williams, S. C.; Van Hemert, L.] Kings Coll London, Inst Psychiat, Ctr Neuroimaging Sci, London SE5 8AF, England.
RP Ecker, C (reprint author), Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England.
EM christine.ecker@kcl.ac.uk
RI Williams, Steve/D-6979-2011; Ecker, Christine/E-5194-2010
FU Medical Research Council UK [G0400061, G0800298]; Dr. Mortimer and
   Theresa Sackler Foundation; EU-AIMS project (European Autism
   Interventions-a Multicentre Study for developing New Medications) from
   the Innovative Medicines Initiative Joint Undertaking [115300]; EU; NIHR
   Biomedical Research Centre for Mental Health at King's College London,
   Institute of Psychiatry; South London & Maudsley NHS Foundation Trust
FX This work was supported (1) by the Medical Research Council UK (G0400061
   and G0800298), (2) by the Dr. Mortimer and Theresa Sackler Foundation,
   (3) by the EU-AIMS project (European Autism Interventions-a Multicentre
   Study for developing New Medications) receiving support from the
   Innovative Medicines Initiative Joint Undertaking under grant agreement
   no. 115300, which includes financial contributions from the EU Seventh
   Framework Programme (FP7/2007-2013), (4) by the NIHR Biomedical Research
   Centre for Mental Health at King's College London, Institute of
   Psychiatry, and (5) by the South London & Maudsley NHS Foundation Trust.
   We are also grateful to those who agreed to be scanned and who gave
   their time so generously to this study.
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Blakemore SJ, 2008, NAT REV NEUROSCI, V9, P267, DOI 10.1038/nrn2353
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
   Doyle-Thomas KAR, 2013, J CHILD NEUROL, V28, P729, DOI 10.1177/0883073812451496
   Ecker C, 2013, P NATL ACAD SCI USA, V110, P13222, DOI 10.1073/pnas.1221880110
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Ecker C, 2013, JAMA PSYCHIAT, V70, P59, DOI 10.1001/jamapsychiatry.2013.265
   Fischl B, 1999, HUM BRAIN MAPP, V8, P272, DOI 10.1002/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4
   Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
   Gaffrey MS, 2007, NEUROPSYCHOLOGIA, V45, P1672, DOI 10.1016/j.neuropsychologia.2007.01.008
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158
   Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
   Hardan AY, 2009, BIOL PSYCHIAT, V66, P320, DOI 10.1016/j.biopsych.2009.04.024
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Huttenlocher PR, 1997, J COMP NEUROL, V387, P167, DOI 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
   Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
   Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040
   Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018
   Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
   Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mak-Fan KM, 2012, J AUTISM DEV DISORD, V42, P419, DOI 10.1007/s10803-011-1261-6
   McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332
   Miyata T, 2004, DEVELOPMENT, V131, P3133, DOI 10.1242/dev.01173
   Mundy P, 2010, AUTISM, V14, P408, DOI 10.1177/1362361310366315
   Noctor SC, 2004, NAT NEUROSCI, V7, P136, DOI 10.1038/nn1172
   Nordahl CW, 2012, ARCH GEN PSYCHIAT, V69, P53, DOI 10.1001/archgenpsychiatry.2011.145
   Panizzon MS, 2009, CEREB CORTEX, V19, P2728, DOI 10.1093/cercor/bhp026
   Patterson K, 2007, NAT REV NEUROSCI, V8, P976, DOI 10.1038/nrn2277
   Paus T, 2005, TRENDS COGN SCI, V9, P60, DOI 10.1016/j.tics.2004.12.008
   Pessoa L, 2008, NAT REV NEUROSCI, V9, P148, DOI 10.1038/nrn2317
   Pontious A, 2008, DEV NEUROSCI-BASEL, V30, P24, DOI 10.1159/000109848
   RAKIC P, 1995, TRENDS NEUROSCI, V18, P383, DOI 10.1016/0166-2236(95)93934-P
   Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
   Raznahan A, 2011, J NEUROSCI, V31, P7174, DOI 10.1523/JNEUROSCI.0054-11.2011
   Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020
   Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040
   Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
   Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007
   Segonne F, 2004, NEUROIMAGE, V22, P1060, DOI 10.1016/j.neuroimage.2004.03.032
   Shaw P, 2006, ARCH GEN PSYCHIAT, V63, P540, DOI 10.1001/archpsyc.63.5.540
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Waiter GD, 2004, NEUROIMAGE, V22, P619, DOI 10.1016/j.neuroimage.2004.02.029
   Wallace GL, 2013, BRAIN, V136, P1956, DOI 10.1093/brain/awt106
   Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
   Winkler AM, 2012, NEUROIMAGE, V61, P1428, DOI 10.1016/j.neuroimage.2012.03.026
   Worsley KJ, 1999, HUM BRAIN MAPP, V8, P98, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<98::AID-HBM5>3.0.CO;2-F
NR 57
TC 2
Z9 2
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1157
EP 1170
DI 10.1007/s00702-014-1207-1
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400007
PM 24752753
ER

PT J
AU Greimel, E
   Schulte-Ruther, M
   Kamp-Becker, I
   Remschmidt, H
   Herpertz-Dahlmann, B
   Konrad, K
AF Greimel, Ellen
   Schulte-Ruether, Martin
   Kamp-Becker, Inge
   Remschmidt, Helmut
   Herpertz-Dahlmann, Beate
   Konrad, Kerstin
TI Impairment in face processing in autism spectrum disorder: a
   developmental perspective
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Autism spectrum disorder; Development; Age; Face recognition; Emotion
ID HIGH-FUNCTIONING ADULTS; FACIAL EXPRESSION; EMOTION RECOGNITION;
   ASPERGER-SYNDROME; BRAIN ACTIVATION; CHILDREN; PERCEPTION; AMYGDALA;
   INFORMATION; CHILDHOOD
AB Findings on face identity and facial emotion recognition in autism spectrum disorder (ASD) are inconclusive. Moreover, little is known about the developmental trajectory of face processing skills in ASD. Taking a developmental perspective, the aim of this study was to extend previous findings on face processing skills in a sample of adolescents and adults with ASD. N = 38 adolescents and adults (13-49 years) with high-functioning ASD and n = 37 typically developing (TD) control subjects matched for age and IQ participated in the study. Moreover, n = 18 TD children between the ages of 8 and 12 were included to address the question whether face processing skills in ASD follow a delayed developmental pattern. Face processing skills were assessed using computerized tasks of face identity recognition (FR) and identification of facial emotions (IFE). ASD subjects showed impaired performance on several parameters of the FR and IFE task compared to TD control adolescents and adults. Whereas TD adolescents and adults outperformed TD children in both tasks, performance in ASD adolescents and adults was similar to the group of TD children. Within the groups of ASD and control adolescents and adults, no age-related changes in performance were found. Our findings corroborate and extend previous studies showing that ASD is characterised by broad impairments in the ability to process faces. These impairments seem to reflect a developmentally delayed pattern that remains stable throughout adolescence and adulthood.
C1 [Greimel, Ellen; Schulte-Ruether, Martin; Konrad, Kerstin] Rhein Westfal TH Aachen, Univ Hosp, Dept Child & Adolescent Psychiat, Child Neuropsychol Sect, D-52062 Aachen, Germany.
   [Greimel, Ellen; Herpertz-Dahlmann, Beate] Rhein Westfal TH Aachen, Univ Hosp, Dept Child & Adolescent Psychiat, D-52062 Aachen, Germany.
   [Greimel, Ellen] Univ Hosp Munich, Dept Child & Adolescent Psychiat, D-80336 Munich, Germany.
   [Kamp-Becker, Inge; Remschmidt, Helmut] Univ Hosp Giessen & Marburg, Dept Child & Adolescent Psychiat, Giessen, Germany.
RP Greimel, E (reprint author), Univ Hosp Munich, Dept Child & Adolescent Psychiat, Pettenkoferstr 8a, D-80336 Munich, Germany.
EM Ellen.Greimel@med.uni-muenchen.de
RI Konrad, Kerstin/H-7747-2013
OI Konrad, Kerstin/0000-0001-9039-2615
FU Vifor Pharma; Novartis; Medice
FX B. H.-D. receives industry research funding from Vifor Pharma. K. K.
   received speaking fees from Novartis and Medice. All other authors
   declare that they have no conflicts of interest.
CR Achenbach TM, 1993, EMPIRICALLY BASED TA
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Aylward EH, 2005, J COGNITIVE NEUROSCI, V17, P308, DOI 10.1162/0898929053124884
   Aylward EH, 1999, NEUROLOGY, V53, P2145
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Barkley R., 1995, ADHD REPORT, V3, P6
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Batty M, 2006, DEVELOPMENTAL SCI, V9, P207, DOI 10.1111/j.1467-7687.2006.00480.x
   Baudouin JY, 2010, J EXP CHILD PSYCHOL, V107, P195, DOI 10.1016/j.jecp.2010.05.008
   Blass EM, 2004, COGNITION, V92, P305, DOI 10.1016/j.cognition.2003.10.004
   Boelte S, 2006, BEHAV NEUROSCI, V120, P211
   Boelte S, 2006, FRAGEBOGEN SOZIALEN
   Boelte S, 2006, ADI R DIAGNOSTISCHES
   Boelte S, 2003, PSYCHOL MED, V33, P907
   Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
   BORMANNKISCHKEL C, 1995, J CHILD PSYCHOL PSYC, V36, P1243, DOI 10.1111/j.1469-7610.1995.tb01368.x
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   CAREY S, 1980, DEV PSYCHOL, V16, P257, DOI 10.1037/0012-1649.16.4.257
   Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
   Crookes K, 2009, COGNITION, V111, P219, DOI 10.1016/j.cognition.2009.02.004
   Dalton KM, 2007, BIOL PSYCHIAT, V61, P512, DOI 10.1016/j.biopsych.2006.05.019
   Derogatis L. R., 1993, BRIEF SYMPTOM INVENT
   Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
   DeSonneville LMJ, 2001, ANT 2 1 AMSTERDAM NE
   Doepfner M, 1994, HDB ELTERNFRAGEBOGEN
   Durand K, 2007, J EXP CHILD PSYCHOL, V97, P14, DOI 10.1016/j.jecp.2006.12.001
   Dyck MJ, 2006, J CLIN CHILD ADOLESC, V35, P20, DOI 10.1207/s15374424jccp3501_3
   Flowe HD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037253
   Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218
   Greimel E, 2010, J NEURAL TRANSM, V117, P781, DOI 10.1007/s00702-010-0404-9
   Guyer AE, 2008, J COGNITIVE NEUROSCI, V20, P1565, DOI 10.1162/jocn.2008.20114
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Herba C, 2004, J CHILD PSYCHOL PSYC, V45, P1185, DOI 10.1111/j.1469-7610.2004.00316.x
   HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
   HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
   Humphreys K, 2007, NEUROPSYCHOLOGIA, V45, P685, DOI 10.1016/j.neuropsychologia.2006.08.003
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Kirchner JC, 2011, J AUTISM DEV DISORD, V41, P158, DOI 10.1007/s10803-010-1032-9
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   KOLB B, 1992, BRAIN COGNITION, V20, P74, DOI 10.1016/0278-2626(92)90062-Q
   Krebs JF, 2011, J AUTISM DEV DISORD, V41, P796, DOI 10.1007/s10803-010-1098-4
   Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
   Lahaie A, 2006, NEUROPSYCHOLOGY, V20, P30, DOI 10.1037/0894-4105.20.1.30
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339
   Monk CS, 2003, NEUROIMAGE, V20, P420, DOI 10.1016/S1053-8119(03)00355-0
   Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
   O'Connor K, 2005, BRAIN COGNITION, V59, P82, DOI 10.1016/j.bandc.2005.05.004
   O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024
   Organization WH, 1993, ICD 10 CLASS MENT BE
   Peelen MV, 2009, DEVELOPMENTAL SCI, V12, pF16, DOI 10.1111/j.1467-7687.2009.00916.x
   Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
   Rossion Bruno, 2002, Behav Cogn Neurosci Rev, V1, P63, DOI 10.1177/1534582302001001004
   Ruehl D, 2004, ADOS DIAGNOSTISCHE B
   Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
   Uono S, 2011, SOC NEUROSCI-UK, V6, P452, DOI 10.1080/17470919.2011.605593
   WalkerAndrews AS, 1997, PSYCHOL BULL, V121, P437, DOI 10.1037/0033-2909.121.3.437
   Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
   Wang AT, 2006, SOC COGN AFFECT NEUR, V1, P107, DOI 10.1093/scan/nsl018
   Wechsler D., 1991, MANUAL WECHSLER INTE
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
   Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
   Wright B, 2008, AUTISM, V12, P607, DOI 10.1177/1362361308097118
   Young A. M., 1987, PERCEPTION, V10, P747, DOI DOI 10.1068/P160747
NR 74
TC 0
Z9 0
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1171
EP 1181
DI 10.1007/s00702-014-1206-2
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400008
PM 24737035
ER

PT J
AU de Vries, M
   Geurts, HM
AF de Vries, Marieke
   Geurts, Hilde M.
TI Beyond individual differences: are working memory and inhibition
   informative specifiers within ASD?
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE ASD; WM; Inhibition; Individual differences
ID AUTISM SPECTRUM DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   N-BACK TASK; DISRUPTIVE BEHAVIOR DISORDERS; LATENT-VARIABLE ANALYSIS;
   DIAGNOSTIC OBSERVATION SCHEDULE; DEFICIT HYPERACTIVITY DISORDER;
   EXECUTIVE FUNCTION DEFICITS; RESPONSE-INHIBITION; PSYCHIATRIC-DISORDERS
AB Findings on working memory (WM) and inhibition in children with autism spectrum disorders (ASD) are contradictory and earlier studies largely ignored individual differences. As WM and inhibition seem to be related, children who experience WM deficits might also experience inhibition deficits. Moreover, these children possibly form a distinct subgroup, differing on other variables, such as cognitive functioning, symptom severity, behavior, and attention deficit hyperactivity disorder (ADHD) characteristics. We studied a large sample of children with and without ASD (8-12 years, IQ > 80) with classic experimental tasks (n-back task, ASD n = 77, control n = 45; stop task, ASD n = 74, control n = 43), and explored individual differences. The ASD group made more errors on the n-back task with increasing WM load, and had longer stop signal reaction times on the stop task when compared with controls. However, only 6 % of the ASD group showed both WM and inhibition deficits, and 71 % showed no deficits. Parents of children with WM and/or inhibition deficits tended to report more conduct problems on the disruptive behavior disorder rating scale. ADHD characteristics did not influence performance. Some children used medication during testing, which seemingly influenced stop task performance, but excluding these data did not change the main findings. Large individual differences in cognitive functioning are present, even within children with ASD with average or above average intelligence. However, whether individual differences in specific cognitive domains, such as WM and inhibition are as informative as individual differences in diagnosis, comorbidity, and general cognitive functioning, calls for future research.
C1 [de Vries, Marieke; Geurts, Hilde M.] Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands.
   [Geurts, Hilde M.] Autism Outpatient Clin, Amsterdam, Netherlands.
   [Geurts, Hilde M.] Cognit Sci Ctr Amsterdam, Amsterdam, Netherlands.
RP Geurts, HM (reprint author), Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands.
EM m.devries@uva.nl; h.m.geurts@uva.nl
CR Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3
   Altgassen M, 2010, J NEURODEV DISORD, V2, P2, DOI 10.1007/s11689-009-9030-y
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Andersen PN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064842
   Andersen PN, 2014, AUTISM, DOI [10.1177/1362361314524844, DOI 10.1177/1362361314524844]
   Antrop I, 2002, J PSYCHOPATHOL BEHAV, V24, P67, DOI 10.1023/A:1014057325752
   Barnard L, 2008, AUTISM, V12, P125, DOI 10.1177/1362361307088486
   Barneveld PS, 2013, J INT NEUROPSYCH SOC, V19, P646, DOI 10.1017/S1355617713000167
   Bennetto L, 1996, CHILD DEV, V67, P1816, DOI 10.1111/j.1467-8624.1996.tb01830.x
   Berger HJC, 2003, J CLIN EXP NEUROPSYC, V25, P502, DOI 10.1076/jcen.25.4.502.13870
   Bodin D, 2009, CHILD NEUROPSYCHOL, V15, P417, DOI 10.1080/09297040802603661
   Brackenridge R, 2011, RES DEV DISABIL, V32, P2797, DOI 10.1016/j.ridd.2011.05.027
   CASEY BJ, 1995, NEUROIMAGE, V2, P221, DOI 10.1006/nimg.1995.1029
   Chatham CH, 2011, J COGNITIVE NEUROSCI, V23, P3598, DOI 10.1162/jocn_a_00047
   Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
   Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256
   Collett BR, 2003, J AM ACAD CHILD PSY, V42, P1015, DOI 10.1097/01.CHI.0000070245.24125.B6
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Cui JF, 2010, J AUTISM DEV DISORD, V40, P958, DOI 10.1007/s10803-010-0943-9
   De Jonge M, 2007, NEDERLANDSE BEWERKIN
   de Vries M, 2012, J AUTISM DEV DISORD, V42, P2558, DOI 10.1007/s10803-012-1512-1
   Diamond A, 2013, ANNU REV PSYCHOL, V64, P135, DOI 10.1146/annurev-psych-113011-143750
   Diamond A, 2012, CURR DIR PSYCHOL SCI, V21, P335, DOI 10.1177/0963721412453722
   Engelhardt PE, 2008, J ABNORM PSYCHOL, V117, P591, DOI 10.1037/a0012593
   Fair DA, 2012, P NATL ACAD SCI USA, V109, P6769, DOI 10.1073/pnas.1115365109
   Field A., 2009, DISCOVERING STAT USI
   Friedman NP, 2004, J EXP PSYCHOL GEN, V133, P101, DOI 10.1037/0096-3445.133.1.101
   Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
   Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
   Garon N, 2008, PSYCHOL BULL, V134, P31, DOI 10.1037/0033-2909.134.1.31
   Gathercole SE, 2004, DEV PSYCHOL, V40, P177, DOI 10.1037/0012-1649.40.2.177
   Geurts HM, 2008, J CHILD PSYCHOL PSYC, V49, P848, DOI 10.1111/j.1469-7610.2008.01916.x
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
   Geurts HM, 2014, AUTISM RES, V7, P407, DOI 10.1002/aur.1369
   Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504
   Gomarus HK, 2009, CLIN NEUROPHYSIOL, V120, P60, DOI 10.1016/j.clinph.2008.10.018
   Gray KM, 2008, J AUTISM DEV DISORD, V38, P657, DOI 10.1007/s10803-007-0432-y
   Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hobson CW, 2011, J CHILD PSYCHOL PSYC, V52, P1035, DOI 10.1111/j.1469-7610.2011.02454.x
   Holmes J, 2010, APPL COGNITIVE PSYCH, V24, P827, DOI 10.1002/acp.1589
   Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
   Johnson MH, 2012, TRENDS COGN SCI, V16, P454, DOI 10.1016/j.tics.2012.07.001
   Kane MJ, 2007, J EXP PSYCHOL LEARN, V33, P615, DOI 10.1037/0278-7393.33.3.615
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Kort W, 2002, WISC 3 NL HANDLEIDIN
   Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Lauritsen MB, 2013, EUR CHILD ADOLES PSY, V22, pS37, DOI 10.1007/s00787-012-0359-5
   Lecavalier L, 2006, AM J MENT RETARD, V111, P199, DOI 10.1352/0895-8017(2006)111[199:VOTADI]2.0.CO;2
   Lehto JE, 2003, BRIT J DEV PSYCHOL, V21, P59, DOI 10.1348/026151003321164627
   Lejbak L, 2011, BRAIN COGNITION, V76, P191, DOI 10.1016/j.bandc.2010.12.002
   Lemon JM, 2011, J AUTISM DEV DISORD, V41, P352, DOI 10.1007/s10803-010-1039-2
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lipszyc J, 2010, J INT NEUROPSYCH SOC, V16, P1064, DOI 10.1017/S1355617710000895
   Logan GD, 1997, PSYCHOL SCI, V8, P60, DOI 10.1111/j.1467-9280.1997.tb00545.x
   LOGAN GD, 1984, PSYCHOL REV, V91, P295, DOI 10.1037//0033-295X.91.3.295
   Logan G.D., 1994, ABILITY INHIBIT THOU
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   Mcnab F, 2008, NEUROPSYCHOLOGIA, V46, P2668, DOI 10.1016/j.neuropsychologia.2008.04.023
   Minamoto T, 2010, BRAIN RES, V1335, P63, DOI 10.1016/j.brainres.2010.03.088
   Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
   Miyake A, 2012, CURR DIR PSYCHOL SCI, V21, P8, DOI 10.1177/0963721411429458
   Morein-Zamir S, 2008, J ABNORM CHILD PSYCH, V36, P1199, DOI 10.1007/s10802-008-9243-7
   Oord S, 2012, CHILD NEUROPSYCHOL, V18, P50, DOI [10.1080/09297049.2011.559159, DOI 10.1080/09297049.2011.559159]
   Oosterlaan J, 1998, J CHILD PSYCHOL PSYC, V39, P411, DOI 10.1017/S0021963097002072
   Oosterlaan J., 2000, HANDLEIDING BIJ VRAG
   Ozonoff S, 1997, J AUTISM DEV DISORD, V27, P59, DOI 10.1023/A:1025821222046
   PELHAM WE, 1992, J AM ACAD CHILD PSY, V31, P210, DOI 10.1097/00004583-199203000-00006
   Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287
   Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x
   Pellicano E, 2012, AUTISM RES TREAT
   Redick TS, 2013, PSYCHON B REV, P1
   Redick TS, 2011, J EXP PSYCHOL LEARN, V37, P308, DOI 10.1037/a0022216
   Regier DA, 2013, WORLD PSYCHIATRY, V12, P92, DOI 10.1002/wps.20050
   Reiersen AM, 2011, J AM ACAD CHILD PSY, V50, P857, DOI 10.1016/j.jaac.2011.06.012
   Roeyers H., 2011, SCREENINGLIJST AUTIS
   Russell J., 1997, AUTISM EXECUTIVE DIS
   Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
   Rutter M., 2003, ADI R AUTISM DIAGNOS
   Sanderson C, 2013, J AUTISM DEV DISORD, V43, P1065, DOI 10.1007/s10803-012-1650-5
   Sattler J. M., 2001, ASSESSMENT CHILDREN
   Schecklmann M, 2012, J ATTEN DISORD, V17, P470, DOI [10.1177/1087054711429702, DOI 10.1177/1087054711429702]
   Scheres A, 2001, J CHILD PSYCHOL PSYC, V42, P347, DOI 10.1111/1469-7610.00728
   Schleepen TMJ, 2010, DEV NEUROPSYCHOL, V35, P37, DOI 10.1080/87565640903325733
   Schmiedek F, 2009, J EXP PSYCHOL LEARN, V35, P1089, DOI 10.1037/a0015730
   Schoemaker K, 2012, J CHILD PSYCHOL PSYC, V53, P111, DOI 10.1111/j.1469-7610.2011.02468.x
   Severens E, 2005, ACTA PSYCHOL, V119, P159, DOI 10.1016/j.actpsy.2005.01.002
   Shipstead Z, 2012, PSYCHOL BULL, V138, P628, DOI 10.1037/a0027473
   Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4
   Smith EE, 1999, SCIENCE, V283, P1657, DOI 10.1126/science.283.5408.1657
   Storch EA, 2012, CHILD PSYCHIAT HUM D, V43, P734, DOI 10.1007/s10578-012-0294-1
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
   Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028
   Travers BG, 2011, NEUROPSYCHOLOGY AUTI, P161
   van den Wildenberg WPM, 2003, ACTA PSYCHOL, V114, P115, DOI 10.1016/S0001-6918(03)00062-3
   Verte S, 2005, DEV PSYCHOPATHOL, V17, P415, DOI 10.1017/S0954579405050200
   Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5
   Verte S, 2006, J NEUROSCI METH, V151, P5, DOI 10.1016/j.jneumeth.2005.08.023
   Willcutt Erik G., 2008, V24, P195, DOI 10.1159/000118526
   Willcutt EG, 2005, BIOL PSYCHIAT, V57, P1336, DOI 10.1016/j.biopsych.2005.02.006
   Williams DL, 2005, J AUTISM DEV DISORD, V35, P747, DOI 10.1007/s10803-005-0021-x
   Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21
   Wong D, 2006, GENES BRAIN BEHAV, V5, P561, DOI 10.1111/j.1601-183X.2005.00199.x
   Zuddas A, 2006, EUR PSYCHIAT, V21, P410, DOI 10.1016/j.eurpsy.2005.08.001
NR 113
TC 1
Z9 1
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1183
EP 1198
DI 10.1007/s00702-014-1225-z
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400009
PM 24796318
ER

PT J
AU Pankert, A
   Pankert, K
   Herpertz-Dahlmann, B
   Konrad, K
   Kohls, G
AF Pankert, Azarakhsh
   Pankert, Kilian
   Herpertz-Dahlmann, Beate
   Konrad, Kerstin
   Kohls, Gregor
TI Responsivity to familiar versus unfamiliar social reward in children
   with autism
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Autism spectrum disorders; Social reward; Nonsocial reward; Familiarity;
   Cognitive control
ID FUSIFORM FACE AREA; SPECTRUM DISORDERS; BRAIN PLASTICITY; MONETARY
   REWARD; JOINT ATTENTION; ROMANTIC LOVE; MOTIVATION; INTERVENTION;
   DYSFUNCTION; IMPAIRMENT
AB In autism spectrum disorders (ASD), social motivation theories suggest that the core social communication problems seen in children with ASD arise from diminished responsiveness to social reward. Although clinical and experimental data support these theories, the extent to which the reward deficit in ASD is unique for social rewards remains unclear. With the present investigation, we aimed to provide insight into the degree to which sociality as well as familiarity of reward incentives impact motivated goal-directed behavior in children with ASD. To do so, we directly compared the influence of familiar versus unfamiliar social reward relative to nonsocial, monetary reward in children with ASD relative to age- and IQ-matched typically developing controls (TDC) using a visual and auditory incentive go/nogo task with reward contingencies for successful response inhibitions. We found that children with ASD responded stronger to visual familiar and unfamiliar social reward as well as to nonsocial, monetary reward than TDC. While the present data are at odds with predictions made by social motivation theories, individual variations beyond clinical diagnosis, such as reward exposure across various social settings, help explain the pattern of results. The findings of this study stress the necessity for additional research on intra-individual as well as environmental factors that contribute to social reward responsiveness in individuals with ASD versus other neuropsychiatric disorders such as ADHD or conduct disorder.
C1 [Pankert, Azarakhsh; Pankert, Kilian; Konrad, Kerstin; Kohls, Gregor] Rhein Westfal TH Aachen, Child Neuropsychol Sect, Dept Child & Adolescent Psychiat, D-52074 Aachen, Germany.
   [Herpertz-Dahlmann, Beate] Rhein Westfal TH Aachen, Dept Child & Adolescent Psychiat, D-52074 Aachen, Germany.
RP Kohls, G (reprint author), Rhein Westfal TH Aachen, Child Neuropsychol Sect, Dept Child & Adolescent Psychiat, Neuenhofer Weg 21, D-52074 Aachen, Germany.
EM gkohls@ukaachen.de
RI Konrad, Kerstin/H-7747-2013
OI Konrad, Kerstin/0000-0001-9039-2615
FU German Research Foundation (Deutsche Forschungsgemeinschaft/DFG) [IRTG
   1328]
FX We would like to thank all young volunteers and their families who
   participated in this study. We also thank Astrid Putz-Ebert for her help
   with data collection. This study was supported by the German Research
   Foundation (Deutsche Forschungsgemeinschaft/DFG, IRTG 1328). We are also
   very grateful to two anonymous reviewers for their helpful comments on
   earlier versions of the manuscript.
CR Abrams DA, 2013, P NATL ACAD SCI USA, V110, P12060, DOI 10.1073/pnas.1302982110
   Acevedo BP, 2012, SOC COGN AFFECT NEUR, V7, P145, DOI 10.1093/scan/nsq092
   Achenbach TM, 1991, MANUAL CHILD BEHAV C
   Aron A, 2005, J NEUROPHYSIOL, V94, P327, DOI 10.1152/jn.00838.2004
   Assaf M, 2013, NEUROIMAGE-CLIN, V3, P321, DOI 10.1016/j.nicl.2013.09.005
   Bartels A, 2004, NEUROIMAGE, V21, P1155, DOI 10.1016/j.neuroimage.2003.11.003
   Cascio CJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-9
   Cascio CJ, 2013, J CHILD PSYCHOL PSYC, V55, P162
   Casey BJ, 2002, DEV PSYCHOBIOL, V40, P237, DOI 10.1002/dev.10030
   Ceponiene R, 2003, P NATL ACAD SCI USA, V100, P5567, DOI 10.1073/pnas.0835631100
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dawson G, 1998, CHILD DEV, V69, P1276, DOI 10.2307/1132265
   Dawson G, 2001, J AUTISM DEV DISORD, V31, P337, DOI 10.1023/A:1010751404865
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Dawson G, 2003, NOVART FDN SYMP, V251, P266
   Delmonte S, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-7
   Demurie E, 2011, J CHILD PSYCHOL PSYC, V52, P1164, DOI 10.1111/j.1469-7610.2010.02374.x
   Demurie E, 2013, RES DEV DISABIL, V34, P1870, DOI 10.1016/j.ridd.2013.03.011
   Demurie E, 2013, J ATTEN DISORD, DOI [10.1177/1087054712473179, DOI 10.1177/1087054712473179]
   Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
   Dichter GS, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-19
   Dopfner M., 1998, DIAGNOSTIK SYSTEM PS
   Ewing L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079493
   FABES RA, 1989, DEV PSYCHOL, V25, P509, DOI 10.1037/0012-1649.25.4.509
   FREITAG G, 1970, J EXP CHILD PSYCHOL, V9, P436, DOI 10.1016/0022-0965(70)90030-5
   GARRETSON HB, 1990, J AUTISM DEV DISORD, V20, P101, DOI 10.1007/BF02206860
   Geurts HM, 2008, J CHILD PSYCHOL PSYC, V49, P848, DOI 10.1111/j.1469-7610.2008.01916.x
   GEWIRTZ JL, 1958, J ABNORM SOC PSYCH, V57, P165, DOI 10.1037/h0042880
   Gleissner U, 2003, Z NEUROPSYCHOL, V14, P3, DOI 10.1024//1016-264X.14.1.3
   Gossen A, 2014, SOC COGN AFFECT NEUR, V9, P661, DOI 10.1093/scan/nst033
   Grossman JB, 1997, ANN NY ACAD SCI, V807, P440, DOI 10.1111/j.1749-6632.1997.tb51938.x
   Hudry K, 2009, RES AUTISM SPECT DIS, V3, P74, DOI 10.1016/j.rasd.2008.04.004
   Jones EJH, 2013, DEV NEUROPSYCHOL, V38, P58, DOI 10.1080/87565641.2012.727049
   Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
   Kamp-Becker I, 2005, Z KINDER JUG-PSYCH, V33, P15, DOI 10.1024/1422-4917.33.1.15
   Kanner L, 1943, NERV CHILD, V2, P217
   KASARI C, 1993, DEV PSYCHOPATHOL, V5, P403, DOI 10.1017/S0954579400004491
   KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995
   KNOTT F, 1995, J CHILD PSYCHOL PSYC, V36, P965, DOI 10.1111/j.1469-7610.1995.tb01343.x
   Koegel RL, 2001, J CLIN CHILD PSYCHOL, V30, P19, DOI 10.1207/S15374424JCCP3001_4
   Kohls G, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-10
   Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1
   Kohls G, 2013, SOC COGN AFFECT NEUR, V8, P565, DOI 10.1093/scan/nss033
   Kohls G, 2013, NEUROPSYCHOLOGIA, V51, P2062, DOI 10.1016/j.neuropsychologia.2013.07.020
   Kohls G, 2009, DEVELOPMENTAL SCI, V12, P614, DOI 10.1111/j.1467-7687.2009.00816.x
   KONSTANTAREAS MM, 1992, J MARRIAGE FAM, V54, P153, DOI 10.2307/353283
   Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x
   Kylliainen A, 2012, J CHILD PSYCHOL PSYC, V53, P790, DOI 10.1111/j.1469-7610.2011.02522.x
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lin A, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00143
   Lloyd-Fox S, 2013, P ROY SOC B-BIOL SCI, V280, DOI 10.1098/rspb.2012.3026
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   LORD C, 1986, J AUTISM DEV DISORD, V16, P249, DOI 10.1007/BF01531658
   Luman M, 2005, CLIN PSYCHOL REV, V25, P183, DOI 10.1016/j.cpr.2004.11.001
   Luman M, 2010, NEUROSCI BIOBEHAV R, V34, P744, DOI 10.1016/j.neubiorev.2009.11.021
   Matson JL, 1996, RES DEV DISABIL, V17, P433, DOI 10.1016/S0891-4222(96)00030-3
   Matthys W, 1998, J CHILD PSYCHOL PSYC, V39, P643, DOI 10.1017/S0021963098002534
   Mobbs D, 2009, PSYCHOL SCI, V20, P955, DOI 10.1111/j.1467-9280.2009.02399.x
   MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
   Munson J, 2008, J INT NEUROPSYCH SOC, V14, P956, DOI 10.1017/S1355617708081393
   Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
   O'Connor K, 2008, J AUTISM DEV DISORD, V38, P1989, DOI 10.1007/s10803-008-0559-5
   Ortigue S, 2007, J COGNITIVE NEUROSCI, V19, P1218, DOI 10.1162/jocn.2007.19.7.1218
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Pierce K, 2008, BIOL PSYCHIAT, V64, P552, DOI 10.1016/j.biopsych.2008.05.013
   Pierce K, 2004, BRAIN, V127, P2703, DOI 10.1093/brain/awh289
   POWER TJ, 1992, J ABNORM CHILD PSYCH, V20, P579, DOI 10.1007/BF00911242
   Ruble LA, 2001, J AUTISM DEV DISORD, V31, P471, DOI 10.1023/A:1012264808377
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sasson NJ, 2008, AUTISM RES, V1, P31, DOI 10.1002/aur.4
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
   van der Meer JMJ, 2012, J AM ACAD CHILD PSY, V51, P1160, DOI 10.1016/j.jaac.2012.08.024
   Vaughan Van Hecke A., 2009, CHILD DEV, V80, P1118, DOI DOI 10.1111/J.1467-8624.2009.01320.X
   Vloet TD, 2011, Z KINDER JUG-PSYCH, V39, P341, DOI 10.1024/1422-4917/a000127
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
NR 82
TC 3
Z9 3
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2014
VL 121
IS 9
SI SI
BP 1199
EP 1210
DI 10.1007/s00702-014-1210-6
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO1TB
UT WOS:000341096400010
PM 24728874
ER

PT J
AU Veness, C
   Prior, M
   Eadie, P
   Bavin, E
   Reilly, S
AF Veness, Carly
   Prior, Margot
   Eadie, Patricia
   Bavin, Edith
   Reilly, Sheena
TI Predicting autism diagnosis by 7 years of age using parent report of
   infant social communication skills
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Article
DE autism; infant; longitudinal study; non-verbal communication; social
   interaction
ID SPECTRUM DISORDERS; EARLY INDICATORS; HOME VIDEOTAPES; 2ND YEAR;
   CHILDREN; LANGUAGE; LIFE
AB Aim: The aim of this study is to identify social communication skills in infancy which predict autism spectrum disorder (ASD) diagnosis by 7 years as compared with children with other developmental difficulties or typical development from within a population sample.
   Methods: Children with an ASD (n = 41), developmental delay (n = 28), language impairment (n = 47) and typical development (n = 41) were drawn from a large, longitudinal community sample following children from 8 months to 7 years of age, the Early Language in Victoria Study. At 7 years of age, early social communication skills at 8, 12 and 24 months from the Communication and Symbolic Behavior Scales Infant-Toddler Checklist and the MacArthur-Bates Communicative Development Inventory: Words and Gestures were compared between groups and used to predict ASD diagnosis.
   Results: Significant predictors of ASD diagnosis were found from 8 months, predominantly focused on gesture use and communicative behaviours, such as requesting and joint attention. While comparisons between children with ASD and children with language impairment and typical development revealed differences from 8 months of age, the developmental delay group did not differ significantly from ASD on any measure until 24 months of age. At 24 months, children with ASD had lower Communication and Symbolic Behavior Scales Use of Communication scores as compared with all other groups.
   Conclusions: The capacity to identify early markers of ASD should facilitate awareness of the risk of an ASD as compared with other developmental problems and point to the need for further developmental assessment, monitoring and provision of early intervention if indicated.
C1 [Veness, Carly; Eadie, Patricia; Reilly, Sheena] Royal Childrens Hosp, Murdoch Childrens Res Inst, Hearing Language & Literacy Grp, Melbourne, Vic, Australia.
   [Prior, Margot] Univ Melbourne, Melbourne, Vic, Australia.
   [Eadie, Patricia] Univ Melbourne, Dept Audiol & Speech Pathol, Melbourne, Vic, Australia.
   [Reilly, Sheena] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.
   [Bavin, Edith] La Trobe Univ, Sch Psychol Sci, Melbourne, Vic, Australia.
RP Reilly, S (reprint author), Royal Childrens Hosp, Murdoch Childrens Res Inst, Flemington Rd, Parkville, Vic 3052, Australia.
EM sheena.reilly@mcri.edu.au
FU National Health and Medical Research Council (NHMRC) [1041947, 607407,
   1023493]; Victorian Government Operational Infrastructure Support
   Program; NHMRC [1041892]; Nadia Verrall Memorial Research Grant from
   Speech Pathology Australia; Syd and Ann Wellard Memorial Trust
FX ELVS was supported by the National Health and Medical Research Council
   (NHMRC) Project Grants (#1041947, #607407 and #1023493) and the
   Victorian Government Operational Infrastructure Support Program. SR was
   supported by the NHMRC practitioner fellowship (#1041892). The ELVS
   Autism study was supported by the Nadia Verrall Memorial Research Grant
   from Speech Pathology Australia and the Syd and Ann Wellard Memorial
   Trust as administered by Equity Trustees Limited. The authors would like
   to acknowledge and thank all participating families and the ELVS
   research assistants.
CR Allen CW, 2007, J AUTISM DEV DISORD, V37, P1272, DOI 10.1007/s10803-006-0279-7
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Australian Bureau of Statistics, 2001, SOC EC IND AR
   Barbaro J, 2013, AUTISM, V17, P64, DOI 10.1177/1362361312442597
   Fenson L, 2007, MACARTHUR BATES COMM
   Mitchell S, 2006, J DEV BEHAV PEDIATR, V27, pS69, DOI 10.1097/00004703-200604002-00004
   Reilly S, 2006, J PAEDIATR CHILD H, V42, P764, DOI 10.1111/j.1440-1754.2006.00974.x
   Reilly S, 2007, PEDIATRICS, V120, pE1441, DOI 10.1542/peds.2007-0045
   Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
   Rutter M, 2008, SOCIAL COMMUNICATION
   Semel E., 2006, CLIN EVALUATION LANG, V4th
   Shumway S, 2009, J SPEECH LANG HEAR R, V52, P1139, DOI 10.1044/1092-4388(2009/07-0280)
   Stata Statistical Software, 2007, STAT STAT SOFTW VERS
   Tomblin JB, 1997, J SPEECH LANG HEAR R, V40, P1245
   Trillingsgaard A, 2005, EUR CHILD ADOLES PSY, V14, P65, DOI 10.1007/s00787-005-0433-3
   Veness C, 2012, AUTISM, V16, P163, DOI 10.1177/1362361311399936
   Ventola P, 2007, J AUTISM DEV DISORD, V37, P425, DOI 10.1007/s10803-006-0177-z
   Watson LR, 2013, AM J SPEECH-LANG PAT, V22, P25, DOI 10.1044/1058-0360(2012/11-0145)
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
   Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
   Wetherby A. M., 2001, COMMUNICATION SYMBOL
   Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
NR 24
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1034-4810
EI 1440-1754
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD SEP
PY 2014
VL 50
IS 9
BP 693
EP 700
DI 10.1111/jpc.12614
PG 8
WC Pediatrics
SC Pediatrics
GA AO2HV
UT WOS:000341141200007
PM 24909517
ER

PT J
AU McLean, RL
   Harrison, AJ
   Zimak, E
   Joseph, RM
   Morrow, EM
AF McLean, Rebecca L.
   Harrison, Ashley Johnson
   Zimak, Eric
   Joseph, Robert M.
   Morrow, Eric M.
TI Executive Function in Probands With Autism With Average IQ and Their
   Unaffected First-Degree Relatives
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism spectrum disorder; executive functioning; adaptive functioning;
   IQ; pedigree
ID TRAUMATIC BRAIN-INJURY; SPECTRUM DISORDERS; COGNITIVE PHENOTYPE;
   CHILDREN; INDIVIDUALS; PARENTS; IMPAIRMENTS; DYSFUNCTION; CHILDHOOD;
   PROFILES
AB Objective: This study aimed to characterize executive function (EF) in pedigrees of children with autism spectrum disorder (ASD) and average IQ. The authors examined the hypothesis that deficits in EF relate to lower levels of adaptive functioning, and they assessed evidence for a cognitive extended phenotype in unaffected relatives in a large, well-characterized sample. Method: Proband EF was assessed by parent-report questionnaires (Behavior Rating Inventory of Executive Functioning [BRIEF], n = 109) and child neuropsychological tests (Delis-Kaplan Executive Functioning System [D-KEFS], n = 35). EF also was examined in parents (D-KEFS, n = 335) and unaffected siblings (BRIEF, n = 114; D-KEFS, n = 57). Adaptive functioning was assessed by the Vineland Adaptive Behavior Scales-II (n = 155). All data were obtained from the Autism Consortium Clinical Genetics Database. Results: Individuals with ASD showed important EF weaknesses. Multiple regression analyses showed that parent-reported EF deficits were related to profound decreases in adaptive functioning even after controlling for age, IQ and severity of ASD symptoms. Parent-reported EF also was related to adaptive skills in preschoolers. First-degree unaffected relatives did not demonstrate difficulties with EF compared with normative data. Conclusion: In this study, EF impairments do not appear to relate to broad familial risk factors for ASD but may be associated with factors relevant to the expression of ASD in probands. Results support the benefits of EF assessment as a way to identify potential therapeutic targets that could lead to improved adaptive behavior in children with ASD and average IQ.
C1 [McLean, Rebecca L.; Morrow, Eric M.] Brown Univ, Sch Med, Emma Pendleton Bradley Hosp, Dev Disorders Genet Res Program, Providence, RI 02912 USA.
   [McLean, Rebecca L.] Mem Hosp Rhode Isl, Neurodev Ctr, Pawtucket, RI USA.
   [Harrison, Ashley Johnson; Zimak, Eric] Emma Pendleton Bradley Hosp, Dev Disorders Genet Res Program, East Providence, RI USA.
   [Harrison, Ashley Johnson; Zimak, Eric] Brown Univ, Med Sch, Providence, RI 02912 USA.
   [Joseph, Robert M.] Boston Univ, Sch Med, Boston, MA 02215 USA.
   [Joseph, Robert M.; Morrow, Eric M.] Autism Consortium, Boston, MA USA.
   [Morrow, Eric M.] Brown Univ, Brown Inst Brain Sci, Providence, RI 02912 USA.
RP Morrow, EM (reprint author), Brown Univ, Mol Med Lab, 70 Ship St, Providence, RI 02912 USA.
EM eric_morrow@brown.edu
RI Joseph, Roy/D-8530-2015
FU Dr. Morrow's Career Award in Medical Science from the Burroughs Wellcome
   Fund; National Institutes of Health (NIH) / National Institute of
   General Medical Sciences (NIGMS) [P20GM103645 01A1]; Autism Consortium;
   NIMH [1R01MH085143, 1R01MH083565]
FX This research was supported by Dr. Morrow's Career Award in Medical
   Science from the Burroughs Wellcome Fund and the National Institutes of
   Health (NIH) / National Institute of General Medical Sciences (NIGMS)
   grant P20GM103645 01A1 : Project Award under Neuroscience COBRE Project.
   The collection of data and biomaterials comes from the Phenotypic and
   Genetic Factors in Autism Spectrum Disorders Study. Since 2008, this
   project has been supported by the Autism Consortium and by NIMH grants
   (1R01MH085143, principal investigator, Louis M. Kunkel, PhD;
   1R01MH083565, principal investigator, Christopher Walsh, MD, PhD)
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
   Bolte S, 2002, CHILD PSYCHIAT HUM D, V33, P165, DOI 10.1023/A:1020734325815
   Delis DC, 2001, DELIS KAPLAN EXECUTI
   Delorme R, 2007, EUR PSYCHIAT, V22, P32, DOI 10.1016/j.eurpsy.2006.05.002
   Duncan AW, 2013, AUTISM
   Eigsti I. M., 2011, NEUROPSYCHOLOGY AUTI, P185
   Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504
   Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P121
   Gioia GA, 1996, BEHAV RATING INVENTO
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Hughes C, 1997, PSYCHOL MED, V27, P209, DOI 10.1017/S0033291796004308
   Hughes C, 1999, J CHILD PSYCHOL PSYC, V40, P705, DOI 10.1017/S0021963099004023
   Ikuta T, 2014, PSYCHIAT RES-NEUROIM, V221, P63, DOI 10.1016/j.pscychresns.2013.08.002
   Isquith PK, 2005, MENT RETARD DEV D R, V11, P209, DOI 10.1002/mrdd.20075
   Joseph R, 2011, NEUROPSYCHOLOGY AUTI, P281
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P1007, DOI 10.1007/s10803-010-1126-4
   Kenworthy L, 2014, J CHILD PSYCHOL PSYC, V55, P374, DOI 10.1111/jcpp.12161
   Kenworthy L, 2009, CHILD NEUROPSYCHOL, V15, P425, DOI 10.1080/09297040802646983
   Kenworthy LE, 2005, DEV NEUROPSYCHOL, V28, P809, DOI 10.1207/s15326942dn2803_4
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Latzman RD, 2010, ASSESSMENT, V17, P172, DOI 10.1177/1073191109356254
   Lezak MD, 2012, NEUROPSYCHOLOGICAL A, V5th
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   MacAllister WS, 2012, CHILD NEUROPSYCHOL, V18, P404, DOI 10.1080/09297049.2011.613812
   Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
   Payne JM, 2011, CHILD NEUROPSYCHOL, V17, P313, DOI 10.1080/09297049.2010.542746
   Pellicano E, 2012, AUTISM RES TREAT, V2012, P146
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Rosenthal M, 2013, NEUROPSYCHOLOGY, V27, P13, DOI 10.1037/a0031299
   Rozga A, 2011, NEUROPSYCHOLOGY AUTI, P97
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sayers N, 2011, J INTELL DISABIL RES, V55, P699, DOI 10.1111/j.1365-2788.2010.01370.x
   Semrud-Clikeman M, 2010, J AUTISM DEV DISORD, V40, P1017, DOI 10.1007/s10803-010-0951-9
   Smithson PE, 2013, J AUTISM DEV DISORD, V43, P1967, DOI 10.1007/s10803-012-1747-x
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Sumiyoshi C, 2011, NEUROSCI RES, V69, P252, DOI 10.1016/j.neures.2010.11.007
   Vriezen ER, 2002, CHILD NEUROPSYCHOL, V8, P296, DOI 10.1076/chin.8.4.296.13505
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wecshler D, 2002, WECHSLER PRESCHOOL P
   Wilde EA, 2012, INT J DEV NEUROSCI, V30, P267, DOI 10.1016/j.ijdevneu.2012.01.003
   Wong D, 2006, GENES BRAIN BEHAV, V5, P561, DOI 10.1111/j.1601-183X.2005.00199.x
NR 46
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2014
VL 53
IS 9
BP 1001
EP 1009
DI 10.1016/j.jaac.2014.05.019
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AO3HW
UT WOS:000341221300010
PM 25151423
ER

PT J
AU Crider, A
   Pandya, CD
   Peter, D
   Ahmed, AO
   Pillai, A
AF Crider, Amanda
   Pandya, Chirayu D.
   Peter, Diya
   Ahmed, Anthony O.
   Pillai, Anilkumar
TI Ubiquitin-proteasome dependent degradation of GABA(A)alpha 1 in autism
   spectrum disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; GABA(A) receptor; Ubiquitination; SYVN1; Neurons
ID ENDOPLASMIC-RETICULUM; RECEPTORS; SYSTEM; PHOSPHORYLATION; EXPRESSION;
   RETENTION; EPILEPSY; MUTATION; PATHWAY; CORTEX
AB Background: Although the neurobiological basis of autism spectrum disorder (ASD) is not fully understood, recent studies have indicated the potential role of GABA(A) receptors in the pathophysiology of ASD. GABA(A) receptors play a crucial role in various neurodevelopmental processes and adult neuroplasticity. However, the mechanism(s) of regulation of GABA(A) receptors in ASD remains poorly understood.
   Methods: Postmortem middle frontal gyrus tissues (13 ASD and 13 control subjects) were used. In vitro studies were performed in primary cortical neurons at days in vitro (DIV) 14. The protein levels were examined by western blotting. Immunofluorescence studies were employed for cellular localization. The gene expression was determined by RT-PCR array and qRT-PCR.
   Results: A significant decrease in GABA(A)alpha 1 protein, but not mRNA levels was found in the middle frontal gyrus of ASD subjects indicating a post-translational regulation of GABA(A) receptors in ASD. At the cellular level, treatment with proteasomal inhibitor, MG132, or lactacystin significantly increased GABA(A)alpha 1 protein levels and Lys48-linked polyubiquitination of GABA(A)alpha 1, but reduced proteasome activity in mouse primary cortical neurons (DIV 14 from E16 embryos). Moreover, treatment with betulinic acid, a proteasome activator significantly decreased GABA(A alpha)1 protein levels in cortical neurons indicating the role of polyubiquitination of GABA(A)alpha 1 proteins with their subsequent proteasomal degradation in cortical neurons. Ubiquitination specific RT-PCR array followed by western blot analysis revealed a significant increase in SYVN1, an endoplasmic reticulum (ER)-associated degradation (ERAD) E3 ubiquitin ligase in the middle frontal gyrus of ASD subjects. In addition, the inhibition of proteasomal activity by MG132 increased the expression of GABA(A)alpha 1 in the ER. The siRNA knockdown of SYVN1 significantly increased GABA(A)alpha 1 protein levels in cortical neurons. Moreover, reduced association between SYVN1 and GABA(A)alpha 1 was found in the middle frontal gyrus of ASD subjects.
   Conclusions: SYVN1 plays a critical role as an E3 ligase in the ubiquitin proteasome system (UPS)-mediated GABA(A)a1 degradation. Thus, inhibition of the ubiquitin-proteasome-mediated GABA(A)alpha 1 degradation may be an important mechanism for preventing GABA(A)alpha 1 turnover to maintain GABA(A)alpha 1 levels and GABA signaling in ASD.
C1 [Crider, Amanda; Pandya, Chirayu D.; Peter, Diya; Pillai, Anilkumar] Georgia Regents Univ, Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA.
   [Ahmed, Anthony O.] Will Cornell Med Coll, Dept Psychiat, White Plains, NY 10605 USA.
RP Pillai, A (reprint author), Georgia Regents Univ, Med Coll Georgia, Dept Psychiat & Hlth Behav, 997 St Sebastian Way, Augusta, GA 30912 USA.
EM apillai@gru.edu
FU NIH [HHSN275200900011C, NO1-HD-9-0011]
FX Human postmortem samples were obtained from the NICHD Brain and Tissue
   Bank for Developmental Disorders at the University of Maryland,
   Baltimore, MD, USA. The Bank is funded by NIH Contract No.
   #HHSN275200900011C, Ref. No. NO1-HD-9-0011.
CR Akerman CJ, 2007, TRENDS NEUROSCI, V30, P382, DOI 10.1016/j.tins.2007.06.002
   Arancibia-Carcamo IL, 2009, P NATL ACAD SCI USA, V106, P17552, DOI 10.1073/pnas.0905502106
   Barendse EM, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-14
   Barker JL, 1998, PERSPECT DEV NEUROBI, V5, P305
   Beneyto M, 2011, CEREB CORTEX, V21, P999, DOI 10.1093/cercor/bhq169
   Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005
   Conti F, 2004, BRAIN RES REV, V45, P196, DOI 10.1016/j.brainsrev.2004.03.003
   Di Cristo G, 2007, CLIN GENET, V72, P1, DOI 10.1111/j.1399-0004.2007.00822.x
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Fujita E, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2010.23
   Gallagher MJ, 2005, J BIOL CHEM, V280, P37995, DOI 10.1074/jbc.M508305200
   Glickman MH, 2002, PHYSIOL REV, V82, P373, DOI 10.1152/physrev.00027.2001
   Hershko A, 1998, ANNU REV BIOCHEM, V67, P425, DOI 10.1146/annurev.biochem.67.1.425
   Howell KR, 2013, NEUROSCI LETT, V552, P30, DOI 10.1016/j.neulet.2013.07.032
   Jarome TJ, 2013, NEUROBIOL LEARN MEM, V105, P107, DOI 10.1016/j.nlm.2013.03.009
   Kang JQ, 2004, J NEUROSCI, V24, P8672, DOI 10.1523/JNEUROSCI.2717-04.2004
   Mohler H, 2006, CELL TISSUE RES, V326, P505, DOI 10.1007/s00441-006-0284-3
   Oblak A, 2009, AUTISM RES, V2, P205, DOI 10.1002/aur.88
   Oblak AL, 2011, BRAIN RES, V1380, P218, DOI 10.1016/j.brainres.2010.09.021
   Pickart CM, 2004, CELL, V116, P181, DOI 10.1016/S0092-8674(03)01074-2
   Rossignol E, 2011, NEURAL PLAST, DOI 10.1155/2011/649325
   Rudolph U, 1999, NATURE, V401, P796, DOI 10.1038/44579
   Tolkacheva T, 2001, CANCER RES, V61, P4985
   WISDEN W, 1992, J NEUROSCI, V12, P1040
   Zemoura K, 2013, J BIOL CHEM, V288, P34897, DOI 10.1074/jbc.M113.514745
   Zemoura K, 2014, J BIOL CHEM, V289, P7738, DOI 10.1074/jbc.M113.541987
   Zikopoulos B, 2013, FRONT HUM NEUROSCI, V7, P1, DOI 10.3389/fnhum.2013.00609
NR 29
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 1
PY 2014
VL 5
AR 45
DI 10.1186/2040-2392-5-45
PG 10
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AO2NC
UT WOS:000341159500001
PM 25392730
ER

PT J
AU Dickerson, AS
   Pearson, DA
   Loveland, KA
   Rahbar, MH
   Filipek, PA
AF Dickerson, Aisha S.
   Pearson, Deborah A.
   Loveland, Katherine A.
   Rahbar, Mohammad H.
   Filipek, Pauline A.
TI Role of parental occupation in autism spectrum disorder diagnosis and
   severity
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Diagnosis; Severity; Risk; Occupation; Parents
ID INTERGENERATIONAL TRANSMISSION; GENERAL-POPULATION; JAMAICAN CHILDREN;
   PHENOTYPE; EXPOSURE; LEAD; MATHEMATICIANS; ADOLESCENTS; SIBLINGS;
   MERCURY
AB Some have suggested that parents of children with autism spectrum disorder (ASD) may present with less recognizable autistic-like phenotypic characteristics, leading them to highly systemizing occupations. Using secondary analysis of data from two previous studies of children with ASD, we tested associations between parental occupations and ASD diagnosis and the association of parental occupational characteristics on ASD severity. We found that fathers in healthcare (P < 0.01) and finance (P = 0.03) were more likely to have children with ASD. Additionally, joint effects of parental technical occupations were associated with communication (P < 0.01) and social impairment (P = 0.04). These results support that a "broader phenotype" and possible assortative mating in adults with autistic-like characteristics might contribute to intergenerational transmission and having offspring with greater ASD severity. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Dickerson, Aisha S.; Rahbar, Mohammad H.] Univ Texas Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci EHGES, Houston, TX USA.
   [Dickerson, Aisha S.; Rahbar, Mohammad H.] Univ Texas Houston, Hlth Sci Ctr, Ctr Clin & Translat Sci, Biostat Epidemiol Res Design Core, Houston, TX 77030 USA.
   [Pearson, Deborah A.; Loveland, Katherine A.] Univ Texas Houston, Sch Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Filipek, Pauline A.] Univ Texas Houston, Hlth Sci Ctr, Childrens Learning Inst, Dept Pediat, Houston, TX 77030 USA.
   [Filipek, Pauline A.] Univ Texas Houston, Hlth Sci Ctr, Div Child & Adolescent Neurol, Houston, TX 77030 USA.
RP Dickerson, AS (reprint author), Univ Texas Houston, Hlth Sci Ctr, Ctr Clin & Translat Sci, Biostat Epidemiol Res Design Core, UT Profess Bldg Suite 1100-05, Houston, TX 77030 USA.
EM Aisha.S.Dickerson@uth.tmc.edu; Deborah.A.Pearson@uth.tmc.edu;
   Katherine.A.Loveland@uth.tmc.edu; Mohammad.H.Rahbar@uth.tmc.edu;
   Pauline.A.Filipek@uth.tmc.edu
CR Adams JB, 2013, BIOL TRACE ELEM RES, V151, P171, DOI 10.1007/s12011-012-9551-1
   Adams JB, 2007, J TOXICOL ENV HEAL A, V70, P1046, DOI 10.1080/15287390601172080
   Adolphs R, 2008, CURR BIOL, V18, P1090, DOI 10.1016/j.cub.2008.06.073
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Autism and Developmental Disabilities Monitoring Network (ADDM) Surveillance Year 2010 Principal Investigators, 2014, CTR DIS CONTROL PREV, V63, P1
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2006, ARCH DIS CHILD, V91, P2
   Baron-Cohen Simon, 1997, AUTISM, V1, P101, DOI 10.1177/1362361397011010
   Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
   Blake J., 2013, S DAK J MED, V773, P58
   Bolte S, 2007, J AUTISM DEV DISORD, V37, P243, DOI 10.1007/s10803-006-0165-3
   Briskman J, 2001, J CHILD PSYCHOL PSYC, V42, P309, DOI 10.1111/1469-7610.00724
   Buchen L, 2011, NATURE, V479, P25, DOI 10.1038/479025a
   Bureau of Labor and Statistics (BLS), 2013, STAND OCC CLASS SOC
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Dawson G, 2007, J AUTISM DEV DISORD, V37, P523, DOI 10.1007/s10803-006-0182-2
   Fitzgerald M, 2002, J AUTISM DEV DISORD, V32, P59
   Herbert MR, 2006, NEUROTOXICOLOGY, V27, P671, DOI 10.1016/j.neuro.2006.03.017
   Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
   Holzer L, 2006, J AUTISM DEV DISORD, V36, P249, DOI 10.1007/s10803-005-0053-2
   Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
   Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
   James I, 2003, MATH INTELL, V25, P62, DOI 10.1007/BF02984863
   Jerrold C., 1998, AUTISM, V2, P281
   Kano Y, 2004, PSYCHIAT CLIN NEUROS, V58, P348, DOI 10.1111/j.1440-1819.2004.01266.x
   Kim Y, 2013, NEUROTOXICOLOGY, V35, P15, DOI 10.1016/j.neuro.2012.11.006
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kinney DK, 2010, MED HYPOTHESES, V74, P102, DOI 10.1016/j.mehy.2009.07.052
   Kogan M, 2013, CHANGES PREVALENCE P
   Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
   LaSalle JM, 2013, J HUM GENET, V58, P396, DOI 10.1038/jhg.2013.49
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Loveland KA, 2008, NEUROPSYCHOLOGIA, V46, P49, DOI 10.1016/j.neuropsychologia.2007.08.017
   Marques RC, 2009, COGN BEHAV NEUROL, V22, P134, DOI 10.1097/WNN.0b013e3181a72248
   McCanlies EC, 2012, J AUTISM DEV DISORD, V42, P2323, DOI 10.1007/s10803-012-1468-1
   Miodovnik A, 2011, NEUROTOXICOLOGY, V32, P261, DOI 10.1016/j.neuro.2010.12.009
   Miodovnik A, 2011, MT SINAI J MED, V78, P58, DOI 10.1002/msj.20237
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Parajuli RP, 2013, ENVIRON RES, V121, P45, DOI 10.1016/j.envres.2012.10.010
   Pearson DA, 2012, J CHILD ADOL PSYCHOP, V22, P284, DOI 10.1089/cap.2011.0067
   Piven J, 1997, AM J PSYCHIAT, V154, P185
   Pring L, 2012, AUTISM, V16, P45, DOI 10.1177/1362361311403783
   Rahbar MH, 2013, NEUROTOX RES, V23, P22, DOI 10.1007/s12640-012-9321-z
   Rahbar MH, 2002, B WORLD HEALTH ORGAN, V80, P769
   Rahbar MH, 2012, SCI TOTAL ENVIRON, V433, P362, DOI 10.1016/j.scitotenv.2012.06.085
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Roberts JR, 2012, PEDIATRICS, V130, pE1765, DOI 10.1542/peds.2012-2758
   Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
   Rutter M., 2003, SCQ SOCIAL COMMUNICA
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sasson NJ, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-11
   Scheeren AM, 2008, J AUTISM DEV DISORD, V38, P276, DOI 10.1007/s10803-007-0389-x
   Schmidt GL, 2008, J CLIN EXP NEUROPSYC, V30, P557, DOI 10.1080/13803390701551225
   Szatmari P, 2008, J AUTISM DEV DISORD, V38, P1859, DOI 10.1007/s10803-008-0576-4
   Tang DL, 2008, ENVIRON HEALTH PERSP, V116, P674, DOI 10.1289/ehp.10471
   Volk HE, 2014, EPIDEMIOLOGY, V25, P44, DOI 10.1097/EDE.0000000000000030
   Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835
   Volkmar F, 2014, J AM ACAD CHILD PSY, V53, P237, DOI 10.1016/j.jaac.2013.10.013
   Wheelwright S, 2001, AUTISM, V5, P223, DOI 10.1177/1362361301005002010
   Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
   Williams JHG, 2007, EUR CHILD ADOLES PSY, V16, P243, DOI 10.1007/s00787-006-0596-6
   Windham GC, 2009, AUTISM RES, V2, P183, DOI 10.1002/aur.84
   Wong D, 2006, GENES BRAIN BEHAV, V5, P561, DOI 10.1111/j.1601-183X.2005.00199.x
   Young R., 2003, FLINDERS OBSERVATION
NR 67
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 997
EP 1007
DI 10.1016/j.rasd.2014.05.007
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600001
ER

PT J
AU Gargaro, BA
   May, T
   Tonge, BJ
   Sheppard, DM
   Bradshaw, JL
   Rinehart, NJ
AF Gargaro, B. A.
   May, T.
   Tonge, B. J.
   Sheppard, D. M.
   Bradshaw, J. L.
   Rinehart, N. J.
TI Using the DBC-P Hyperactivity Index to screen for ADHD in young people
   with autism and ADHD: A pilot study
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE ADHD; Autism spectrum disorder; Comorbidity; DBC; Hyperactivity
ID PERVASIVE DEVELOPMENTAL DISORDERS; BEHAVIOR CHECKLIST;
   PSYCHIATRIC-DISORDERS; DIAGNOSTIC INTERVIEW; CHILDREN; POPULATION;
   ADOLESCENTS; INSTRUMENT; SYMPTOMS; SAMPLE
AB This study aimed to (1) determine preliminary validity of the Developmental Behaviour Checklist-Hyperactivity Index (DBC-HI) as a screening measure of combined-type ADHD in autism and ADHD, and (2) compare emotional-behavioural disturbance using the DBC in autism, ADHD and autism + ADHD. Forty-nine age- and PIQ-matched young people [6-18 years; 12 autism, 13 ADHD, 12 autism + ADHD, 12 typically developing] were recruited. Parents completed the Conners-Revised Rating Scale and DBC. The DBC-HI displayed strong internal consistency and good external validity, reliably measuring combined-type ADHD. The DBC-HI distinguished autism from autism + ADHD with fair sensitivity and specificity. Individuals with autism + ADHD exhibited a more severe profile of emotional-behavioural disturbance than autism or ADHD alone. The DBC may be a useful 'all-in-one' screening tool to (1) identify comorbidity and (2) determine the severity of emotional-behavioural disturbance in autism and/or ADHD. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Gargaro, B. A.; Tonge, B. J.; Bradshaw, J. L.] Monash Univ, Sch Psychol & Psychiat, Clayton, Vic 3800, Australia.
   [May, T.; Rinehart, N. J.] Deakin Univ, Burwood, Vic 3125, Australia.
   [Sheppard, D. M.] Monash Univ, Monash Univ Accid Res Ctr, Monash Injury Res Inst, Clayton, Vic 3800, Australia.
RP May, T (reprint author), Deakin Univ, 221 Burwood Highway, Burwood, Vic 3125, Australia.
EM Tamara.May@deakin.edu.au
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
   Brereton AV, 2002, J AM ACAD CHILD PSY, V41, P1369, DOI 10.1097/01.CHI.0000024838.94814.A5
   Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50
   Conners C. K., 1997, CONNERS RATING SCALE
   Dekker MC, 2002, J INTELL DISABIL RES, V46, P61, DOI 10.1046/j.1365-2788.2002.00353.x
   Einfeld S., 1992, MANUAL DEV BEHAV CHE
   Einfeld S. L., 2002, MANUAL DEV BEHAV CHE
   EINFELD SL, 1995, J AUTISM DEV DISORD, V25, P81, DOI 10.1007/BF02178498
   Gray K., 2000, J INTELL DISABIL RES, V44, P2999
   Hattori J, 2006, BRAIN DEV-JPN, V28, P371, DOI 10.1016/j.braindev.2005.11.009
   Keen D, 2004, AUTISM, V8, P39, DOI 10.1177/1362361304040637
   Kenway E., 1994, THESIS MACQUARIE U S
   Kramer M. S., 1988, CLIN EPIDEMIOLOGY BI, P205
   Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
   Ruggieri V. L., 2006, REV NEUROLOGIA, V42, P51
   Saemundsen E, 2003, J AUTISM DEV DISORD, V33, P319, DOI 10.1023/A:1024410702242
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
NR 23
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1008
EP 1015
DI 10.1016/j.rasd.2014.05.004
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600002
ER

PT J
AU Brady, DI
   Saklofske, DH
   Schwean, VL
   Montgomery, JM
   McCrimmon, AW
   Thorne, KJ
AF Brady, Danielle I.
   Saklofske, Donald H.
   Schwean, Vicki L.
   Montgomery, Janine M.
   McCrimmon, Adam W.
   Thorne, Keoma J.
TI Cognitive and emotional intelligence in young adults with Autism
   Spectrum Disorder without an accompanying intellectual or language
   disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Asperger's syndrome; Autism Spectrum Disorder; Cognitive intelligence;
   Emotional intelligence; Neuropsychology and young adults
ID ASPERGERS SYNDROME; SOCIAL INTELLIGENCE; INDIVIDUALS; HEALTH
AB Research in the neurosciences has identified distinctions between neural structures that subserve cognitive intelligence (CI) and those subserving emotional intelligence (EI). This study explored the performance of young adults with Autism Spectrum Disorder (ASD) without an accompanying intellectual or language disorder relative to typically-developing peers, on indices of CI and EI. Both the ASD and age- and sex-matched typically-developing groups exhibited high average cognitive intellectual abilities. In contrast, the ASD group reported lower levels of EI relative to their typically-developing peers, as expected given the social and emotional challenges faced by individuals with ASD. Importantly, cognitive intelligence did not correlate with EI in either group. Taken together, these findings further support the theory of dissociable neural systems underlying CI and EI. These findings also highlight the need to address not only the intellectual aspects of cognition, but also the emotional components to increase understanding of, and improve treatment for individuals on the autism spectrum. This understanding would enhance our ability to assess and support young adults with ASD, and ultimately ease their transition into adulthood. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
C1 [Brady, Danielle I.; McCrimmon, Adam W.; Thorne, Keoma J.] Univ Calgary, Div Appl Psychol, Calgary, AB T2N 1N4, Canada.
   [Saklofske, Donald H.] Univ Western Ontario, Social Sci Ctr, Dept Psychol, London, ON N6A 5C2, Canada.
   [Schwean, Vicki L.] Univ Western Ontario, Fac Educ, London, ON N6G 1G7, Canada.
   [Montgomery, Janine M.] Univ Manitoba, Dept Psychol, Winnipeg, MB R3T 2N2, Canada.
RP Brady, DI (reprint author), POB 21055,110 Columbia Blvd West, Lethbridge, AB T1K 6X4, Canada.
EM dbrady@ucalgary.ca
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Austin E. J., 2005, INT HDB EMOTIONAL IN
   Bar-On R, 2010, S AFR J PSYCHOL, V40, P54
   Bar-On R, 2003, BRAIN, V126, P1790, DOI 10.1093/brain/awg177
   Bar-On R., 2002, BAR EMOTIONAL QUOTIE
   Bar-On R., 1997, BAR EMOTIONAL QUOTIE
   Bar-On R, 2006, PSICOTHEMA, V18, P13
   Bechara A., 2000, BRAIN, V123, P189, DOI DOI 10.1093/BRAIN/123.11.2189
   Bechara A., 2006, ED PEOPLE BE EMOTION, P295
   Bechara A., 2000, HDB EMOTIONAL INTELL, P192
   Bracken B. A., 1987, J PSYCHOEDUCATIONAL, V4, P313, DOI 10.1177/073428298700500402
   Campbell JM, 2005, J AUTISM DEV DISORD, V35, P25, DOI 10.1007/s10803-004-1028-4
   Damasio A., 1994, DESCARTES ERROR EMOT
   DAVIES S, 1994, J CHILD PSYCHOL PSYC, V35, P1033, DOI 10.1111/j.1469-7610.1994.tb01808.x
   Dogget R. A., 2005, REV BAR EMOTIONAL QU
   EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x
   Frith U, 1991, AUTISM ASPERGER SYND
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
   Grossman JB, 1997, ANN NY ACAD SCI, V807, P440, DOI 10.1111/j.1749-6632.1997.tb51938.x
   Hobson P., 1998, PSYCHOL MED, V16, P439
   Krug D. A., 2003, KRUG ASPERGER DISORD
   Lopes PN, 2003, PERS INDIV DIFFER, V35, P641, DOI 10.1016/S0191-8869(02)00242-8
   Lopes PN, 2004, PERS SOC PSYCHOL B, V30, P1018, DOI 10.1177/0146167204264762
   Matthews G, 2002, EMOTIONAL INTELLIGENCE: SCIENCE AND MYTH, P1
   Mayer JD, 1999, INTELLIGENCE, V27, P267, DOI 10.1016/S0160-2896(99)00016-1
   Mayer JD, 1996, INTELLIGENCE, V22, P89, DOI 10.1016/S0160-2896(96)90011-2
   Mayer JD, 2000, HDB INTELLIGENCE, P396
   Mayer JD, 2008, ANNU REV PSYCHOL, V59, P507, DOI 10.1146/annurev.psych.59.103006.093646
   Montgomery J., 2007, THESIS
   Montgomery JM, 2010, EDUC TRAIN AUTISM DE, V45, P566
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
   Nellis L. M, 2005, MENTAL MEASUREMENTS, V16
   Petrides KV, 2011, AUTISM, V15, P671, DOI 10.1177/1362361310397217
   Saklofske DH, 2003, PERS INDIV DIFFER, V34, P707, DOI 10.1016/S0191-8869(02)00056-9
   Slaski M, 2002, STRESS HEALTH, V18, P63, DOI 10.1002/smi.926
   SMITH IM, 1994, PSYCHOL BULL, V116, P259, DOI 10.1037/0033-2909.116.2.259
   Stoesz B. M., 2011, CLIN NEUROPSYCHOL, V2, P376
   Summerfeldt LJ, 2006, J PSYCHOPATHOL BEHAV, V28, P57, DOI 10.1007/s10862-006-4542-1
   SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
   Tantam D., 2000, AUTISM INT J RES PRA, V4, P47, DOI DOI 10.1177/1362361300004001004
   TANTAM D, 1988, J CHILD PSYCHOL PSYC, V29, P245, DOI 10.1111/j.1469-7610.1988.tb00713.x
   TEUNISSE JP, 1994, INT J NEUROSCI, V77, P1
   Wechsler D, 1999, WECHSLER ABBREVIATED
   WING L, 1981, PSYCHOL MED, V11, P115
   Stough C, 2009, SPRINGER SER HUM EXC, P1, DOI 10.1007/978-0-387-88370-0
   Zeidner M, 2012, APPL PSYCHOL-HLTH WE, V4, P1, DOI 10.1111/j.1758-0854.2011.01062.x
NR 48
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1016
EP 1023
DI 10.1016/j.rasd.2014.05.009
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600003
ER

PT J
AU Adams, HL
   Matson, JL
   Jang, J
AF Adams, Hilary L.
   Matson, Johnny L.
   Jang, Jina
TI The relationship between sleep problems and challenging behavior among
   children and adolescents with autism spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Sleep problems; Challenging behavior
ID PERVASIVE DEVELOPMENTAL DISORDER; INTELLECTUAL DISABILITY;
   MENTAL-RETARDATION; ASPERGERS SYNDROME; PDD-NOS; ADULTS; SYMPTOMS;
   INFANTS; ASD; RISPERIDONE
AB Prior research has indicated fairly consistently that sleep problems appear to worsen ASD core symptomatology. As such, the present study was conducted to examine whether or not sleep problems also exacerbate behavior problems commonly exhibited by children and adolescents with ASD in terms of total, internalizing, and externalizing challenging behavior. Results indicated that presence of sleep problems increased the ratings of challenging behavior across types, as hypothesized. Unexpectedly, degree of sleep problem (i.e., mild versus severe) only affected total and externalizing challenging behavior, whereas ratings of internalizing challenging behavior were not significantly different between mild and severe sleep problem groups. Clinical applications of findings, as well as future directions for additional research on the topic of sleep among individuals with ASD, are discussed. Published by Elsevier Ltd.
C1 [Adams, Hilary L.; Matson, Johnny L.; Jang, Jina] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Adams, HL (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM hilary.l.adams@gmail.com
CR Adams HL, 2014, RES AUTISM SPECT DIS, V8, P193, DOI 10.1016/j.rasd.2013.11.008
   Advokat CD, 2000, RES DEV DISABIL, V21, P75, DOI 10.1016/S0891-4222(99)00031-1
   Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P869, DOI 10.1089/cap.2005.15.869
   Benvenuto A, 2013, BRAIN DEV-JPN, V35, P119, DOI 10.1016/j.braindev.2012.03.015
   Brylewski J, 1999, J INTELL DISABIL RES, V43, P504, DOI 10.1046/j.1365-2788.1999.00234.x
   Canitano R, 2011, PROG NEURO-PSYCHOPH, V35, P18, DOI 10.1016/j.pnpbp.2010.10.015
   Cortesi F, 2010, SLEEP MED, V11, P659, DOI 10.1016/j.sleep.2010.01.010
   Coury Daniel L, 2012, Pediatrics, V130 Suppl 2, pS69, DOI 10.1542/peds.2012-0900D
   Emerson E., 2000, CHALLENGING BEHAV AN
   Fodstad JC, 2009, DEV NEUROREHABIL, V12, P152, DOI 10.1080/17518420902936748
   Giannotti F., 2006, J AUTISM DEV DISORDE, V36
   Holden B, 2006, RES DEV DISABIL, V27, P456, DOI 10.1016/j.ridd.2005.06.001
   Homer R. H., 2002, J AUTISM DEV DISORD, V32, P423
   HORNER RH, 1992, J ASSOC PERS SEVERE, V17, P154
   Horovitz M, 2010, DEV NEUROREHABIL, V13, P390, DOI 10.3109/17518423.2010.501431
   Jang JN, 2011, RES AUTISM SPECT DIS, V5, P1028, DOI 10.1016/j.rasd.2010.11.008
   Kozlowski AM, 2012, RES AUTISM SPECT DIS, V6, P385, DOI 10.1016/j.rasd.2011.06.012
   Krakowiak P, 2012, J SLEEP RES, V21, P231, DOI 10.1111/j.1365-2869.2012.01012.x
   Levy A., 2011, RES AUTISM SPECT DIS, V5, P1413
   Liu XC, 2006, CHILD PSYCHIAT HUM D, V37, P179, DOI 10.1007/s10578-006-0028-3
   Logan SL, 2012, ANN EPIDEMIOL, V22, P1, DOI 10.1016/j.annepidem.2011.10.007
   Macken J., 2009, J MENTAL HLTH RES IN, V2, P29
   Malow B, 2006, SLEEP, V29, P15
   Matson J, 2008, J INTELLECT DEV DIS, V33, P323, DOI 10.1080/13668250802492600
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P533, DOI 10.1016/j.rasd.2007.11.001
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P288, DOI 10.1016/j.rasd.2007.07.003
   Matson JL, 2009, RES DEV DISABIL, V30, P572, DOI 10.1016/j.ridd.2008.08.007
   Matson JL, 2007, RES DEV DISABIL, V28, P353, DOI 10.1016/j.ridd.2006.01.005
   Matson JL, 2008, RES DEV DISABIL, V29, P341, DOI 10.1016/j.ridd.2007.06.006
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P237, DOI 10.1016/j.rasd.2007.06.003
   Matson JL, 2007, RES AUTISM SPECT DIS, V1, P28, DOI 10.1016/j.rasd.2006.07.003
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P252, DOI 10.1016/j.rasd.2008.06.005
   Matson JL, 2008, RES DEV DISABIL, V29, P141, DOI 10.1016/j.ridd.2007.02.001
   Matson JL, 2009, RES DEV DISABIL, V30, P1317, DOI 10.1016/j.ridd.2009.05.008
   Matson JL, 2008, J MENT HEALTH RES IN, V1, P129, DOI 10.1080/19315860801988210
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P714, DOI 10.1016/j.rasd.2009.01.008
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   Matson JL, 2007, RES DEV DISABIL, V28, P567, DOI 10.1016/j.ridd.2006.08.001
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P345, DOI 10.1016/j.rasd.2008.08.002
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P400, DOI 10.1016/j.rasd.2009.10.010
   Matson JL, 2008, J DEV PHYS DISABIL, V20, P155, DOI 10.1007/s10882-007-9086-0
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Matson JL, 2007, J INTELLECT DEV DIS, V32, P39, DOI 10.1080/13668250601184689
   Matson JL, 2008, J DEV PHYS DISABIL, V20, P175, DOI 10.1007/s10882-007-9088-y
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P696, DOI 10.1016/j.rasd.2008.02.003
   Matson JL, 2008, LANCET, V371, P9, DOI 10.1016/S0140-6736(08)60046-X
   Matson JL, 2005, RES DEV DISABIL, V26, P399, DOI 10.1016/j.ridd.2004.11.008
   Matson JL, 2009, RES DEV DISABIL, V30, P1203, DOI 10.1016/j.ridd.2009.04.001
   Matson JL, 2010, DEV NEUROREHABIL, V13, P164, DOI 10.3109/17518420903270683
   Matson ML, 2011, RES DEV DISABIL, V32, P2304, DOI 10.1016/j.ridd.2011.07.036
   Remington G, 2001, J CLIN PSYCHOPHARM, V21, P440, DOI 10.1097/00004714-200108000-00012
   Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
   Richdale A, 2001, CLIN DEV MED, P181
   Richdale A, 2000, J INTELLECT DEV DIS, V25, P147
   Richdale AL, 1999, DEV MED CHILD NEUROL, V41, P60, DOI 10.1017/S0012162299000122
   Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
   Schreck KA, 2004, RES DEV DISABIL, V25, P57, DOI 10.1016/j.ridd.2003.04.007
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Singh AN, 2005, RES DEV DISABIL, V26, P203, DOI 10.1016/j.ridd.2004.07.001
   Smith KRM, 2010, RES DEV DISABIL, V31, P743, DOI 10.1016/j.ridd.2010.01.016
   Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
   Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
   Souders MC, 2009, SLEEP, V32, P1566
   Stigler KA, 2014, CHILD ADOL PSYCH CL, V23, P73, DOI 10.1016/j.chc.2013.07.005
   Symons FJ, 2005, J INTELL DISABIL RES, V49, P144, DOI 10.1111/j.1365-2788.2004.00632.x
   Troost PW, 2005, J AM ACAD CHILD PSY, V44, P1137, DOI 10.1097/01.chi.0000177055.11229.76
   Turygin NC, 2013, DEV NEUROREHABIL, V16, P277, DOI 10.3109/17518423.2013.769281
   Vriend JL, 2011, J PEDIATR PSYCHOL, V36, P1017, DOI 10.1093/jpepsy/jsr044
   West L, 2009, J PEDIATR HEALTH CAR, V23, P75, DOI 10.1016/j.pedhc.2008.12.001
   Wiggs L, 1996, J INTELL DISABIL RES, V40, P518, DOI 10.1046/j.1365-2788.1996.799799.x
   Worley JA, 2012, RES AUTISM SPECT DIS, V6, P965, DOI 10.1016/j.rasd.2011.12.012
   Wright B, 2011, J AUTISM DEV DISORD, V41, P175, DOI 10.1007/s10803-010-1036-5
NR 72
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1024
EP 1030
DI 10.1016/j.rasd.2014.05.008
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600004
ER

PT J
AU Rivard, M
   Terroux, A
   Mercier, C
AF Rivard, Melina
   Terroux, Amelie
   Mercier, Celine
TI Effectiveness of early behavioral intervention in public and mainstream
   settings: The case of preschool-age children with autism spectrum
   disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Children with autism spectrum disorders; Early behavioral intervention;
   Intensity; Mainstream day care; Parental coaching; Effectiveness
ID PERVASIVE DEVELOPMENTAL DISORDER; INTENSIVE EARLY INTERVENTION;
   YOUNG-CHILDREN; PSYCHOSOCIAL INTERVENTIONS; CHALLENGING BEHAVIOR;
   MENTAL-RETARDATION; SOCIAL COMPETENCE; PEOPLE; PROGRAM; METAANALYSIS
AB Despite the demonstrated positive outcomes of early intensive behavioral intervention (EIBI) among children with autism spectrum disorders (ASD), several challenges to its implementation on a large scale and in community settings remain. In order to maximize the accessibility and cost-effectiveness of its services, a regional public agency serving children with ASD implemented two consecutive programs: a 1 year pre-program for parents (intensive sessions followed by 1 hour per week of individual coaching) and an early behavioral intervention (EBI) program with less than optimal weekly intensity (16-20 hours) delivered in mainstream day care settings. The outcomes of these programs were assessed among 93 children. Their IQ adaptive behavior, and socioaffective competencies were found to have improved after 12 months in the EBI program. Their autism symptoms had also decreased marginally. Although the pre-program did not have observable effects on children's outcomes, their parents reported positive impact on their well-being and family life. These results demonstrate the feasibility and sustainability of offering EBI to large, unselected populations. However, the pre-program may need to be offered more intensively in order to yield positive outcomes for children. Delivering EBI services in mainstream settings may foster the development of skills linked to social integration. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Rivard, Melina] Univ Quebec Montreal, Dept Psychol, Montreal, PQ H3C 3P8, Canada.
   [Terroux, Amelie] Ctr Readaptat Deficience Intellectuelle & Trouble, St Hubert, PQ, Canada.
   [Mercier, Celine] Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada.
RP Rivard, M (reprint author), Univ Quebec Montreal, Dept Psychol, POB 8888,Succursale Ctr Ville, Montreal, PQ H3C 3P8, Canada.
EM rivard.melina@uqam.ca
CR Al-Salehi SM, 2009, TRANSCULT PSYCHIATRY, V46, P340, DOI 10.1177/1363461509105823
   Anderson S. R., 1987, ED TREATMENT CHILDRE, V10, P352
   Ben-Itzchak E, 2007, RES DEV DISABIL, V28, P287, DOI 10.1016/j.ridd.2006.03.002
   Bigras M., 2002, EARLY EDUC DEV, V13, P139, DOI 10.1207/s15566935eed1302_2
   Bimbrauer J. S., 1993, BEHAV CHANGE, V10, P63
   Boyd RD, 2001, AUTISM, V5, P430, DOI 10.1177/1362361301005004007
   Bryson SE, 2007, RES PRACT PERS SEV D, V32, P142
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   College des medecins & Ordre des psychologies du Quebec, 2012, TROUBL SPECTR LAUT L
   Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
   Dyches TT, 2004, J AUTISM DEV DISORD, V34, P211, DOI 10.1023/B:JADD.0000022611.80478.73
   Eikeseth S, 2012, RES AUTISM SPECT DIS, V6, P829, DOI 10.1016/j.rasd.2011.09.002
   Eikeseth S, 2002, BEHAV MODIF, V26, P49, DOI 10.1177/0145445502026001004
   Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003
   Eldevik S, 2012, J AUTISM DEV DISORD, V42, P210, DOI 10.1007/s10803-011-1234-9
   Eldevik S, 2010, AJIDD-AM J INTELLECT, V115, P381, DOI 10.1352/1944-7558-115.5.381
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Eldevik S, 2006, J AUTISM DEV DISORD, V36, P211, DOI 10.1007/s10803-005-0058-x
   Emerson E, 2008, J POLICY PRACT INTEL, V5, P79, DOI 10.1111/j.1741-1130.2008.00151.x
   Emerson E., 2007, HDB DEV DISABILITIES, P593
   FENSKE EC, 1985, ANAL INTERVEN DEVEL, V5, P49, DOI 10.1016/S0270-4684(85)80005-7
   Garcia S. B., 2009, DELVING DIVERSITY IN, P247
   Granpeesheh D, 2009, RES AUTISM SPECT DIS, V3, P1014, DOI 10.1016/j.rasd.2009.06.007
   Hammes P. S., 2011, SPAN J PSYCHOL, V15, P124
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
   Harvey ST, 2009, J INTELLECT DEV DIS, V34, P67, DOI 10.1080/13668250802690922
   Hastings R. P., 2005, ED PSYCHOL, V25, P207, DOI [10.1080/0144341042000301166, DOI 10.1080/0144341042000301166]
   Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2
   Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
   Hwang B, 2000, J AUTISM DEV DISORD, V30, P331, DOI 10.1023/A:1005579317085
   Ivar Lovaas O., 1987, J CONSULT CLIN PSYCH, V55, P3, DOI DOI 10.1037//0022-006X.55.13
   Jacobson JW, 2000, J AUTISM DEV DISORD, V30, P585, DOI 10.1023/A:1005691411255
   Jones E. W., 2011, J BEHAV ED, V20, P297
   Kasari C, 2010, CURR OPIN NEUROL, V23, P137, DOI 10.1097/WCO.0b013e32833775cd
   LaFreniere P. J., 1992, PSYCHOL ASSESSMENT J, V4, P442, DOI DOI 10.1037/1040-3590.4.4.442
   LaFreniere PJ, 1996, PSYCHOL ASSESSMENT, V8, P369, DOI 10.1037/1040-3590.8.4.369
   Lambrechts G, 2009, J INTELL DISABIL RES, V53, P620, DOI 10.1111/j.1365-2788.2009.01162.x
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Lovaas O. I., 1981, TEACHING DEV DISABLE
   Luiselli J. K., 2000, AUTISM, V4, P426, DOI 10.1177/1362361300004004007
   Maglione Margaret A, 2012, Pediatrics, V130 Suppl 2, pS169, DOI 10.1542/peds.2012-0900O
   Makrygianni MK, 2010, RES AUTISM SPECT DIS, V4, P577, DOI 10.1016/j.rasd.2010.01.014
   Maurice C., 1996, BEHAV INTERVENTION Y
   McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
   Ministere de la sante et des services sociaux, 2003, GEST PORT AV SERV PE
   Mitchell G, 2001, AM J MENT RETARD, V106, P448, DOI 10.1352/0895-8017(2001)106<0448:CBAEIS>2.0.CO;2
   Nahmias A. S., 2012, AUTISM, V18, P311
   National Research Council, 2001, ED CHILDR AUT
   Perry A, 2008, RES AUTISM SPECT DIS, V2, P621, DOI 10.1016/j.rasd.2008.01.002
   Perry A, 2011, RES AUTISM SPECT DIS, V5, P592, DOI 10.1016/j.rasd.2010.07.003
   Prior M., 2011, REV RES IDENTIFY MOS
   Reichow B, 2009, J AUTISM DEV DISORD, V39, P23, DOI 10.1007/s10803-008-0596-0
   Reichow B, 2012, COCHRANE DB SYST REV, V10
   Rivard M., 2013, REV FRANCOPHONE CLIN, V18, P33
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   RoseKrasnor L, 1997, SOC DEV, V6, P111, DOI 10.1111/1467-9507.00029
   Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Schalock R. L., 2010, INTELLECTUAL DISABIL, V11th
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Sheinkopf SJ, 1998, J AUTISM DEV DISORD, V28, P15, DOI 10.1023/A:1026054701472
   Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
   Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
   Smith T, 1997, AM J MENT RETARD, V102, P238, DOI 10.1352/0895-8017(1997)102<0238:IBTFPW>2.0.CO;2
   Smith T, 2000, RES DEV DISABIL, V21, P297, DOI 10.1016/S0891-4222(00)00043-3
   Sparrow SS, 2005, VINELAND 2 REVISION
   Stahmer A. C., 2001, J POSIT BEHAV INTERV, V3, P75, DOI DOI 10.1177/109830070100300203
   Strauss K, 2012, RES DEV DISABIL, V33, P688, DOI 10.1016/j.ridd.2011.11.008
   Tasse MJ, 2010, CAN J BEHAV SCI, V42, P62
   Terpstra J. E., 2008, EARLY CHILDHOOD ED J, V35, P405, DOI DOI 10.1007/S10643-007-0225-0
   Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
   Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
   Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
   Weiss MJ, 1999, BEHAV INTERVENT, V14, P3, DOI 10.1002/(SICI)1099-078X(199901/03)14:1<3::AID-BIN25>3.0.CO;2-F
   Zachor DA, 2007, RES AUTISM SPECT DIS, V1, P304, DOI 10.1016/j.rasd.2006.12.001
NR 80
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1031
EP 1043
DI 10.1016/j.rasd.2014.05.010
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600005
ER

PT J
AU Fisher, WW
   Luczynski, KC
   Hood, SA
   Lesser, AD
   Machado, MA
   Piazza, CC
AF Fisher, Wayne W.
   Luczynski, Kevin C.
   Hood, Stephanie A.
   Lesser, Aaron D.
   Machado, Mychal A.
   Piazza, Cathleen C.
TI Preliminary findings of a randomized clinical trial of a virtual
   training program for applied behavior analysis technicians
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Applied behavior analysis; Autism; Behavioral skills training; Early
   intensive behavioral interventions; Telehealth; Virtual care
ID AUTISM SPECTRUM DISORDERS; YOUNG-CHILDREN; INTERVENTIONS; TELEHEALTH
AB As the demand for applied behavior analysis (ABA) services for children with an autism spectrum disorder continues to grow, it is critical to develop efficient, effective, and widely accessible procedures for training technicians to implement ABA interventions. One approach would be to develop efficacious training programs that could be delivered over the Internet via a virtual private network (VPN). In the current study, we developed a 40-h virtual training program in which participants completed e-learning modules and also received behavioral skills training over a VPN to implement behavior reduction and skill acquisition protocols in both discrete-trail and play-based formats. This virtual training program was evaluated in a randomized-clinical trial (RCT) using direct-observation measures on the implementation of discrete-trial training and play-based procedures as the primary dependent variables (which were also collected via a VPN). Participants in the treatment group showed robust and statistically significant improvement in their implementation of behavior reduction and acquisition programs under both discrete-trial and play-based formats, and they rated the training as highly socially acceptable. These preliminary results from an ongoing RCT suggest that this effective, convenient, and socially acceptable virtual training program has the potential to extend access to ABA services to families in rural and other underserved areas or populations. (C) 2014 Elsevier LtdElsevier Ltd. All rights reserved.
C1 [Fisher, Wayne W.; Luczynski, Kevin C.; Hood, Stephanie A.; Lesser, Aaron D.; Machado, Mychal A.; Piazza, Cathleen C.] Univ Nebraska Med Ctr, Monroe Meyer Inst, Omaha, NE USA.
RP Fisher, WW (reprint author), Ctr Autism Spectrum Disorders, 985450 Nebraska Med Ctr, Omaha, NE 68198 USA.
EM WFisher@UNMC.Edu
CR BAER DM, 1968, J APPL BEHAV ANAL, V1, P91, DOI 10.1901/jaba.1968.1-91
   Barretro A, 2006, J APPL BEHAV ANAL, V39, P333, DOI 10.1901/jaba.2006.173-04
   BURD L, 1987, J AM ACAD CHILD PSY, V26, P700, DOI 10.1097/00004583-198709000-00014
   Buzhardt J., 2005, TEACHING EXCEPTIONAL, V37, P20
   Centers for Disease Control and Prevention, 2012, MMWR-MORBID MORTAL W, V61
   Dave D. M., 2012, 18238 CAL NAT BUR EC
   Defense Health Agency, 2008, ECHO AUT DEM
   Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
   Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Feldman M, 2007, J INTELL DISABIL RES, V51, P606, DOI 10.1111/j.1365-2788.2006.00941.x
   Hamad C. D., 2010, J EARLY INTERVENTION, V23, P1
   Heitzman-Powell LS, 2014, FOCUS AUTISM DEV DIS, V29, P23, DOI 10.1177/1088357613504992
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Howlin P, 2005, J NEURAL TRANSM-SUPP, P101
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
   Jang JN, 2012, RES AUTISM SPECT DIS, V6, P852, DOI 10.1016/j.rasd.2011.11.004
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Lofholm N., 2008, DENVER POST, V168, P904
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   National Autism Center, 2009, NAT STAND PROJ
   Rispoli M, 2011, DEV NEUROREHABIL, V14, P378, DOI 10.3109/17518423.2011.620577
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   SPRAGUE JR, 1984, J APPL BEHAV ANAL, V17, P273, DOI 10.1901/jaba.1984.17-273
   STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
   STOKES TF, 1989, BEHAV THER, V20, P337, DOI 10.1016/S0005-7894(89)80054-1
   Thomson K, 2009, RES AUTISM SPECT DIS, V3, P590, DOI 10.1016/j.rasd.2009.01.003
   Vismara LA, 2009, J AUTISM DEV DISORD, V39, P1636, DOI 10.1007/s10803-009-0796-2
   Wacker DP, 2013, J APPL BEHAV ANAL, V46, P31, DOI 10.1002/jaba.29
   Wacker DP, 2013, J DEV PHYS DISABIL, V25, P35, DOI 10.1007/s10882-012-9314-0
   Xiao L, 2013, J MED INTERNET RES, V15, P279, DOI 10.2196/jmir.2392
NR 32
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1044
EP 1054
DI 10.1016/j.rasd.2014.05.002
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600006
ER

PT J
AU Shih, CH
   Chiang, MS
   Wang, SH
   Chen, CN
AF Shih, Ching-Hsiang
   Chiang, Ming-Shan
   Wang, Shu-Hui
   Chen, Chih-Nung
TI Teaching two teenagers with autism spectrum disorders to request the
   continuation of video playback using a touchscreen computer with the
   function of automatic response to requests
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Touchscreen; ASD; SGD; Communication request
ID CONTROLLING ENVIRONMENTAL STIMULATION; FREE WIRELESS MICE; DESIGNATED
   OCCUPATIONAL ACTIVITIES; FOLLOW SIMPLE INSTRUCTIONS; WII REMOTE
   CONTROLLER; ASSISTING PEOPLE; DEVELOPMENTAL-DISABILITIES;
   PHYSICAL-ACTIVITIES; ENABLING PEOPLE; BALANCE BOARDS
AB This study used a standard touchscreen computer with a newly developed Communication Request and Automatic Response Assistive Program (CRARAP) software package to evaluate whether two people with autism spectrum disorders (ASDs) would be able to actively perform communication requests to continue their preferred environmental stimulation. The CRARAP software was specifically developed for this study to combine the functions of a standard touchscreen computer with a speech-generating device (SGD) and the feature of automatic response to requests. A multiple probe design across participants was adopted in this study. The results show that both participants significantly improved their target responses in terms of performing the correct alternative communication request during the intervention phase, and retained this effective performance in the maintenance phase. The practical and developmental implications of the findings are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Shih, Ching-Hsiang; Chiang, Ming-Shan; Wang, Shu-Hui; Chen, Chih-Nung] Natl Dong Hwa Univ, Dept Special Educ, Hualien 970, Taiwan.
RP Shih, CH (reprint author), Natl Dong Hwa Univ, Dept Special Educ, Hualien 970, Taiwan.
EM schee@mail.ndhu.edu.tw
CR Agree EM, 2011, PHYS THER, V91, P1780, DOI 10.2522/ptj.20100375
   Brodwin MC, 2004, J REHABIL, V70, P28
   Brosnan J, 2011, RES DEV DISABIL, V32, P437, DOI 10.1016/j.ridd.2010.12.023
   Chang ML, 2014, RES DEV DISABIL, V35, P1863, DOI 10.1016/j.ridd.2014.04.011
   Cherry K., 2014, PERCEPTION PERCEPTUA
   Duker P., 2004, ONE ONE TRAINING INS
   Fitzer A., 2008, LANGUAGE AUTISM APPL
   Kagohara DM, 2012, RES AUTISM SPECT DIS, V6, P1224, DOI 10.1016/j.rasd.2012.04.001
   Lenovo, 2014, LEN C560 TOUCH ALL O
   Matson JL, 2011, RES DEV DISABIL, V32, P693, DOI 10.1016/j.ridd.2010.11.012
   Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
   Matson JL, 2012, RES AUTISM SPECT DIS, V6, P144, DOI 10.1016/j.rasd.2011.03.014
   Reed FDD, 2012, RES AUTISM SPECT DIS, V6, P422, DOI 10.1016/j.rasd.2011.07.003
   Richards S. B., 1999, SINGLE SUBJECT RES A
   Shih CH, 2011, RES DEV DISABIL, V32, P2005, DOI 10.1016/j.ridd.2011.04.008
   Shih CH, 2012, RES DEV DISABIL, V33, P2221, DOI 10.1016/j.ridd.2012.06.010
   Shih CH, 2011, RES DEV DISABIL, V32, P818, DOI 10.1016/j.ridd.2010.10.016
   Shih CH, 2011, RES DEV DISABIL, V32, P2780, DOI 10.1016/j.ridd.2011.05.031
   Shih CH, 2013, RES DEV DISABIL, V34, P1521, DOI 10.1016/j.ridd.2013.01.018
   Shih CH, 2011, RES DEV DISABIL, V32, P699, DOI 10.1016/j.ridd.2010.11.011
   Shih CH, 2012, RES DEV DISABIL, V33, P39, DOI 10.1016/j.ridd.2011.08.006
   Shih CH, 2013, RES DEV DISABIL, V34, P1, DOI 10.1016/j.ridd.2012.07.016
   Shih CH, 2011, RES DEV DISABIL, V32, P1631, DOI 10.1016/j.ridd.2011.02.014
   Shih CH, 2012, RES DEV DISABIL, V33, P2013, DOI 10.1016/j.ridd.2012.05.021
   Shih CT, 2013, RES DEV DISABIL, V34, P4328, DOI 10.1016/j.ridd.2013.09.001
   Siegel S., 1988, NONPARAMETRIC STAT B
   Sigafoos J, 2013, RES AUTISM SPECT DIS, V7, P923, DOI 10.1016/j.rasd.2013.04.002
   Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
   Wikipedia, 2014, STIM
NR 29
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1055
EP 1061
DI 10.1016/j.rasd.2014.05.014
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600007
ER

PT J
AU Chuang, IC
   Tseng, MH
   Lu, L
   Shieh, JY
   Cermak, SA
AF Chuang, I-Ching
   Tseng, Mei-Hui
   Lu, Lu
   Shieh, Jeng-Yi
   Cermak, Sharon A.
TI Predictors of the health-related quality of life in preschool children
   with Autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Health-related quality of life; Caregiver's mental health; Parenting
   stress; Preschool children with Autism spectrum disorders
ID PERVASIVE DEVELOPMENTAL DISORDERS; CEREBRAL-PALSY; PSYCHOMETRIC
   PROPERTIES; QUESTIONNAIRE CHQ; MENTAL-HEALTH; DETERMINANTS;
   ASSOCIATIONS; TEMPERAMENT; VALIDATION; CHILDHOOD
AB This study was aimed to identify the predictors of health-related quality of life (HRQOL) by considering the caregiver's characteristics such as mental health and parenting stress as well as child characteristics in preschool children with Autism spectrum disorders (ASD). A total of 106 children aged 36-70 months participated in this study. The study indicated that the predictors of HRQOL in children with ASD encompassed not only child but also caregiver characteristics. In particular, good HRQOL on the domains of social and emotional functioning in children with ASD depended upon the caregiver's mental well-being. In summary, the present findings highlight the need for assessment of caregivers' parenting stress and their mental status as well as the predictors of HRQOL in children with ASD. Furthermore, the findings of the study could serve as a guide for clinicians to target at the predictors when providing assessment and intervention for children with ASD to improve their HRQOL. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Chuang, I-Ching; Tseng, Mei-Hui] Natl Taiwan Univ, Coll Med, Sch Occupat Therapy, Taipei 10055, Taiwan.
   [Tseng, Mei-Hui; Lu, Lu; Shieh, Jeng-Yi] Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Cermak, Sharon A.] Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
RP Tseng, MH (reprint author), Natl Taiwan Univ, Coll Med, Sch Occupat Therapy, Taipei 10055, Taiwan.
EM mhtseng@ntu.edu.tw
CR Abidin RR, 1995, PARENTING STRESS IND
   Achenbach T, 2000, MANUAL ASEBA PRESCHO
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Arnaud C, 2008, PEDIATRICS, V121, P54, DOI 10.1542/peds.2007-0854
   Bastiaansen D, 2005, QUAL LIFE RES, V14, P1599, DOI 10.1007/s11136-004-7711-2
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   CAREY WB, 1970, J PEDIATR-US, V77, P188, DOI 10.1016/S0022-3476(70)80322-5
   CDC, 2014, AUT SPECTR DIS ASDS
   Chen Cheng-Sheng, 2000, Kaohsiung Journal of Medical Sciences, V16, P559
   Chen Y. C., 2009, CHILD BEHAV CHECKL A
   Chen Y. H., 1980, PRELIMINARY STUDY TE
   Cheng T. A., 1988, PSYCHOL MED, V18, P453
   CHENG TA, 1986, PSYCHOL MED, V16, P415
   CHENG TA, 1990, ACTA PSYCHIAT SCAND, V82, P304, DOI 10.1111/j.1600-0447.1990.tb01389.x
   Chess S., 1987, KNOW YOUR CHILD
   CHONG MY, 1989, PSYCHOL MED, V19, P495
   Chuang IC, 2012, RES AUTISM SPECT DIS, V6, P988, DOI 10.1016/j.rasd.2012.01.002
   Dunn W., 1999, SENSORY PROFILE
   Earles T. L., 1998, ED CHILDREN YOUTH AU, P75
   Eiser C, 2000, CHILD CARE HLTH DEV, V26, P401, DOI 10.1046/j.1365-2214.2000.00154.x
   Ferrans CE, 2005, OUTCOMES ASSESSMENT, P14
   Fu CP, 2010, RES AUTISM SPECT DIS, V4, P89, DOI 10.1016/j.rasd.2009.09.002
   Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8
   Hays RD, 2002, ARCH PHYS MED REHAB, V83, pS4, DOI 10.1053/apmr.2002.36837
   Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
   Hollingshead A., 1957, 2 FACTOR INDEX SOC P
   Hsu C. C., 2006, INDIVIDUALIZED 1 DAY
   Huebner E. S, 1991, SCHOOL PSYCHOL QUART, V6, P103, DOI 10.1037/h0088805
   Kahn RS, 2004, ARCH PEDIAT ADOL MED, V158, P721, DOI 10.1001/archpedi.158.8.721
   Kamp-Becker I., 2011, Z KINDER JUGENDPSYCH, V39, P13
   Kose S, 2013, RES AUTISM SPECT DIS, V7, P213, DOI 10.1016/j.rasd.2012.09.009
   Kuhlthau K, 2013, RES AUTISM SPECT DIS, V7, P1035, DOI 10.1016/j.rasd.2013.04.006
   Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2
   Power M, 1998, SOC SCI MED, V46, P1569
   Lee CF, 2005, INT J NURS STUD, V42, P457, DOI 10.1016/j.ijnurstu.2004.08.001
   Lee LC, 2008, J AUTISM DEV DISORD, V38, P1147, DOI 10.1007/s10803-007-0491-0
   Limbers CA, 2009, J AUTISM DEV DISORD, V39, P1529, DOI 10.1007/s10803-009-0777-5
   Manuel J, 2003, J PEDIATR PSYCHOL, V28, P197, DOI 10.1093/jpepsy/jsg007
   Newman P. R., 1997, CHILDHOOD ADOLESCENC
   Patrick DL, 1989, MED CARE S, V27, P217
   Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Schopler E., 2005, EXAMINERS MANUL PSYC
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Thomas A., 1977, TEMPERAMENT DEV
   Tilford JM, 2012, PHARMACOECONOMICS, V30, P661, DOI 10.2165/11597200-000000000-00000
   Tonge B. J., 1999, AUTISM, V3, P117, DOI DOI 10.1177/1362361399003002003
   Tseng M. H., 2008, SENSORY PROFILE CHIN
   Tseng MH, 2011, RES AUTISM SPECT DIS, V5, P1441, DOI 10.1016/j.rasd.2011.02.004
   Villa S, 2010, J AUTISM DEV DISORD, V40, P334, DOI 10.1007/s10803-009-0877-2
   von Rueden U, 2006, J EPIDEMIOL COMMUN H, V60, P130, DOI 10.1136/jech.2005.039792
   Wang P. L., 2002, J TAIPEI MUNICIPAL T, V33, P129
   Waters E, 2000, PEDIATRICS, V106, P1422, DOI 10.1542/peds.106.6.1422
   Weng Y. S., 2003, PARENTING STRESS IND
   White-Konig M, 2007, PEDIATRICS, V120, P804
   Wiley R, 2007, J DEV PHYS DISABIL, V19, P427, DOI 10.1007/s10882-007-9041-0
   Wu W. D., 2004, VINELAND ADAPTIVE BE
   [杨廷忠 Yang Tingzhong], 2003, [中华流行病学杂志, Chinese Journal of Epidemiology], V24, P769
NR 58
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1062
EP 1070
DI 10.1016/j.rasd.2014.05.015
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600008
ER

PT J
AU Stasolla, F
   Perilli, V
   Damiani, R
   Caffo, AO
   Di Leone, A
   Albano, V
   Stella, A
   Damato, C
AF Stasolla, Fabrizio
   Perilli, Viviana
   Damiani, Rita
   Caffo, Alessandro O.
   Di Leone, Antonia
   Albano, Vincenza
   Stella, Anna
   Damato, Concetta
TI A microswitch-cluster program to enhance object manipulation and to
   reduce hand mouthing by three boys with autism spectrum disorders and
   intellectual disabilities
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Microswitch-cluster; Autism spectrum disorders; Developmental
   disabilities; Indices of happiness; Quality of life
ID SCANNING KEYBOARD EMULATOR; MULTIPLE DISABILITIES; MOTOR DISABILITIES;
   DEVELOPMENTAL-DISABILITIES; BEHAVIOR; TECHNOLOGY; CHILDREN; ENGAGEMENT;
   INTERVENTIONS; INDIVIDUALS
AB We assessed a microswitch-cluster program to enhance object manipulation and to reduce hand mouthing by three boys with autism spectrum disorders and severe to profound intellectual disabilities. A second goal of the study was to monitor the effect of such program on the indices of happiness of the participants. The study has been carried out according to an ABB(1)AB(1) sequence, where A represented baseline phases, B represented intervention phase in which the adaptive response (i.e. object manipulation) was followed by a contingent positive stimulation irrespective of challenge behavior (i.e. hand mouthing), and B-1 indicated intervention phases in which an adaptive response was followed by a contingent positive stimulation only if it occurred with the simultaneous absence of the challenge behavior. Otherwise, positive stimulation was interrupted if the challenge behavior was exhibited during its supply. Results showed an increasing of the adaptive responses and a decrease of the challenge behavior during intervention phases. All participants spent less time with the exhibition of challenge behavior, during intervention phases, compared to baseline sessions. Finally, the indices of happiness augmented during intervention phases. Clinical, practical and psychological implications of the findings are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Stasolla, Fabrizio] Lega Filo dOro Res Ctr, Molfetta, Italy.
   [Perilli, Viviana] Lega Filo dOro Res Ctr, Lesmo, Italy.
   [Damiani, Rita; Caffo, Alessandro O.; Di Leone, Antonia; Albano, Vincenza; Stella, Anna; Damato, Concetta] Univ Bari, Dept Educ Sci,Psychol,Commun, I-70121 Bari, Italy.
RP Stasolla, F (reprint author), Lega Filo dOro Res Ctr, Molfetta, Italy.
EM f.stasolla@psico.uniba.it
CR Baeza-Velasco C, 2014, RES AUTISM SPECT DIS, V8, P304, DOI 10.1016/j.rasd.2013.12.004
   Barlow D., 2009, SINGLE CASE EXPT DES
   Cannella HI, 2006, RES DEV DISABIL, V27, P529, DOI 10.1016/j.ridd.2005.06.004
   Crawford MR, 1993, J DEV PHYS DISABIL, V5, P349, DOI 10.1007/BF01046391
   Felce D., 1995, RES DEV DISABIL, V1, P51
   Gould E, 2011, RES AUTISM SPECT DIS, V5, P990, DOI 10.1016/j.rasd.2011.01.012
   Konst MJ, 2013, RES AUTISM SPECT DIS, V7, P1339, DOI 10.1016/j.rasd.2013.07.023
   Lancioni G, 2011, DEV NEUROREHABIL, V14, P60, DOI 10.3109/17518423.2010.526170
   Lancioni G, 2010, DEV NEUROREHABIL, V13, P248, DOI 10.3109/17518423.2010.485596
   Lancioni G. E., 2008, CLIN CASE STUDIES, V7, P238, DOI 10.1177/1534650107307478
   Lancioni Giulio E, 2005, Cogn Process, V6, P177, DOI 10.1007/s10339-005-0003-0
   Lancioni GE, 2014, AUT CHILD PSYCHO, P1, DOI 10.1007/978-1-4899-8029-8
   Lancioni GE, 2007, PERCEPT MOTOR SKILL, V105, P47, DOI 10.2466/PMS.105.1.47-54
   Lancioni GE, 2005, PERCEPT MOTOR SKILL, V100, P892, DOI 10.2466/PMS.100.3.892-894
   Lancioni GE, 2009, RES DEV DISABIL, V30, P20, DOI [10.1016/j.ridd.2008.02.002, 10.1016/j.ridd.2009.03.004]
   Lancioni GE, 2007, J DEV PHYS DISABIL, V19, P593, DOI 10.1007/s10882-007-9073-5
   Lancioni GE, 2006, J INTELL DISABIL RES, V50, P739, DOI 10.1111/j.1365-2788.2006.00839.x
   Lancioni GE, 2013, RES DEV DISABIL, V34, P3411, DOI 10.1016/j.ridd.2013.07.014
   Lancioni GE, 2004, PERCEPT MOTOR SKILL, V99, P724, DOI 10.2466/pms.99.2.724-728
   Lancioni GE, 2007, J VISUAL IMPAIR BLIN, V101, P628
   Lancioni GE, 2006, J DEV PHYS DISABIL, V18, P383, DOI 10.1007/s10882-006-9024-6
   Lancioni GE, 2009, RES DEV DISABIL, V30, P203, DOI 10.1016/j.ridd.2008.03.001
   Lancioni GE, 2012, ASSISTIVE TECHNOLOGY
   Lancioni GE, 2009, RES DEV DISABIL, V30, P378, DOI 10.1016/j.ridd.2008.07.005
   Lancioni GE, 2009, RES DEV DISABIL, V30, P308, DOI 10.1016/j.ridd.2008.05.002
   Lidstone L., 2014, RES AUTISM SPECT DIS, V8, P82
   Machalicek W, 2008, RES AUTISM SPECT DIS, V2, P395, DOI 10.1016/j.rasd.2007.07.001
   Matson JL, 2012, AUT CHILD PSYCHO, P1, DOI 10.1007/978-1-4614-3037-7
   Worley JA, 2011, AUT CHILD PSYCHO, P215, DOI 10.1007/978-1-4419-8065-6_13
   Rellini E, 2004, J AUTISM DEV DISORD, V34, P703, DOI 10.1007/s10803-004-5290-2
   Ripat J., 2005, DISABILITY REHABILIT, V27
   Saunders MD, 2001, J DEV PHYS DISABIL, V13, P27, DOI 10.1023/A:1026505332347
   Siegel S, 1988, NONPARAMETRIC STAT
   Stasolla F, 2013, RES AUTISM SPECT DIS, V7, P1265, DOI 10.1016/j.rasd.2013.07.010
   Stasolla F, 2014, RES AUTISM SPECT DIS, V8, P376, DOI 10.1016/j.rasd.2013.12.020
   Stasolla F, 2013, RES DEV DISABIL, V34, P2694, DOI 10.1016/j.ridd.2013.05.029
   Stasolla F, 2014, RES AUTISM SPECT DIS, V8, P472, DOI 10.1016/j.rasd.2014.01.007
NR 37
TC 3
Z9 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1071
EP 1078
DI 10.1016/j.rasd.2014.05.016
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600009
ER

PT J
AU Hambly, C
   Fombonne, E
AF Hambly, Catherine
   Fombonne, Eric
TI Factors influencing bilingual expressive vocabulary size in children
   with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Language; Vocabulary; Bilingualism; Child
ID LANGUAGE; ENGLISH; TODDLERS; SKILLS
AB This study explored bilingual exposure, language, social impairment and cognitive factors that could influence second language (L2) expressive vocabulary size as measured on the MacArthur-Bates Communicative Development Inventories (various languages) in 33 children (mean age = 60 months) diagnosed with ASD. In the 23 children with L2 vocabularies, recent language exposure estimates accounted for 69% of the variation in L2 vocabulary size, and the VABS-II expressive scale score explained an additional 13% of the difference. The complete sample was then subgrouped into three levels of L2 vocabulary size to compare children with no L2 vocabularies (NON-B, n = 10), low L2 word counts (LOW-B, n = 11) and high L2 counts (HIGH-B, n = 12), as determined by a median split procedure. The HIGH-B group had significantly larger L1 vocabularies than both the LOW-B (p = .045) and the NON-B (p = .003) groups, and higher VABS-II expressive scale scores than both the LOW-B (p = .008) and the NON-B (p = .012) groups. Social impairment did not significantly differ across groups and cognitive impairment did not preclude the development of L2 vocabularies. Expressive bilingualism in this population appears related to high levels of recent direct L2 exposure in combination with stronger dominant language abilities. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Hambly, Catherine; Fombonne, Eric] Oregon Hlth & Sci Univ, Inst Dev & Disabil, Portland, OR 97239 USA.
RP Hambly, C (reprint author), 14 Gulf Lane, Galveston, TX 77550 USA.
EM catherine.hambly@mail.mcgill.ca
CR Bedore LM, 2012, BILING-LANG COGN, V15, P616, DOI 10.1017/S1366728912000090
   Bialystok E., 2001, BILINGUALISM DEV LAN
   Bird EKR, 2012, INT J LANG COMM DIS, V47, P52, DOI 10.1111/j.1460-6984.2011.00071.x
   Bird EKR, 2005, AM J SPEECH-LANG PAT, V14, P187, DOI 10.1044/1058-0360(2005/019)
   Bornstein M. H., 2006, INT J BILINGUAL, V10, P331, DOI [10.1177/13670069060100030401, DOI 10.1177/13670069060100030401]
   Brojde CL, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00155
   Constantino J. N., 2005, MANUAL SOCIAL RESPON
   Constantino JN, 2002, SOCIAL RESPONSIVENES
   Dale P., 1993, SOME SUGGESTIO UNPUB
   David A., 2008, INT J BILING EDUC BI, V11, P598, DOI [10.1080/13670050802149200, DOI 10.1080/13670050802149200]
   Feltmate K., 2008, CANADIAN J SPEECH LA, V32, P6
   Fenson L, 1993, MACARTHUR COMMUNICAT
   Frank I., 1997, INVENTAIRES MACARTHU
   Geangu E., 2006, CHESTIONARUL M UNPUB
   Goldstein BA, 2010, AM J SPEECH-LANG PAT, V19, P238, DOI 10.1044/1058-0360(2010/08-0086)
   Gutierrez-Clellen V, 2012, AM J SPEECH-LANG PAT, V21, P64, DOI 10.1044/1058-0360(2011/10-0090)
   Hambly C, 2012, J AUTISM DEV DISORD, V42, P1342, DOI 10.1007/s10803-011-1365-z
   Hammer CS, 2012, J SPEECH LANG HEAR R, V55, P1251, DOI 10.1044/1092-4388(2012/11-0016)
   Hoff E., 2011, J CHILD LANG, V39, P1
   Jackson-Maldonado D, 2003, MACARTHUR INVENTARIO
   Kjellmer L, 2012, RES DEV DISABIL, V33, P172, DOI 10.1016/j.ridd.2011.09.003
   Korkman M, 2012, ACTA PAEDIATR, V101, P946, DOI 10.1111/j.1651-2227.2012.02733.x
   Kremer-Sadlik T., 2005, P 4 INT S BIL, P1225
   Leadbitter K., 2009, INT M AUT RES CHIC I
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094
   Maital S., 2000, J CHILD LANG, V27, P1
   Ohashi K., 2012, RES AUTISM SPECT DIS, V6, P890
   Oller D., 2010, COMMUNICATION DISORD, V31, P213, DOI DOI 10.1177/1525740109358628
   Paradis J, 2003, J SPEECH LANG HEAR R, V46, P113, DOI 10.1044/1092-4388(2003/009)
   Patterson JL, 2000, J SPEECH LANG HEAR R, V43, P121
   PEARSON BZ, 1993, LANG LEARN, V43, P93, DOI 10.1111/j.1467-1770.1993.tb00174.x
   Petersen JM, 2012, J AUTISM DEV DISORD, V42, P1499, DOI 10.1007/s10803-011-1366-y
   Place S, 2011, CHILD DEV, V82, P1834, DOI 10.1111/j.1467-8624.2011.01660.x
   Seung H, 2006, J MED SPEECH-LANG PA, V14, P53
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Staunton R., 1994, 1 LANGUAGE, V14, P241, DOI 10.1177/014272379401404216
   Valicenti-McDermott M, 2013, J CHILD NEUROL, V28, P945, DOI 10.1177/0883073812453204
   Verhoeven S., 2012, INT J LANG COMM DIS, V47, P176
   Wu J., 1997, THESIS U COLORADO
   Yu B, 2013, AM J SPEECH-LANG PAT, V22, P10, DOI 10.1044/1058-0360(2012/10-0078)
NR 41
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1079
EP 1089
DI 10.1016/j.rasd.2014.05.013
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600010
ER

PT J
AU Uono, S
   Sato, W
   Toichi, M
AF Uono, Shota
   Sato, Wataru
   Toichi, Motorni
TI Reduced representational momentum for subtle dynamic facial expressions
   in individuals with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Dynamic facial expression; Representational
   momentum; Social impairment
ID PERVASIVE DEVELOPMENTAL DISORDER; EMOTIONAL EXPRESSIONS;
   NORMAL-CHILDREN; HUMAN BRAIN; RECOGNITION; PERCEPTION; MOTION;
   ADOLESCENTS; FACE; IMITATION
AB The cognitive mechanisms underlying social communication via emotional facial expressions are crucial for understanding the social impairments experienced by people with autism spectrum disorders (ASD). A recent study (Yoshikawa & Sato, 2008) found that typically developing individuals perceived the last image from a dynamic facial expression to be more emotionally exaggerated than a static facial expression; this perceptual difference is termed representational momentum (RM) for dynamic facial expressions. RM for dynamic facial expressions might be useful for detecting emotion in another's face and for predicting behavior changes. We examined RM for dynamic facial expressions using facial expression stimuli at three levels of emotional intensity (subtle, medium, and extreme) in people with ASD. We predicted that individuals with ASD would show reduced RM for dynamic facial expressions. Eleven individuals with ASD (three with Asperger's disorder and eight with pervasive developmental disorder not otherwise specified) and II IQ-, age- and gender-matched typically developing controls participated in this study. Participants were asked to select an image that matched the final image from dynamic and static facial expressions. Our results revealed that subjectively perceived images were more exaggerated for the dynamic than for the static presentation under all levels of intensity and in both groups. The ASD group, however, perceived a reduced degree of exaggeration for dynamic facial expressions under the subtle intensity condition. As facial expressions are often displayed subtly in daily communications, reduced RM for subtle dynamic facial expressions may prevent individuals with ASD from appropriately interacting with other people as a consequence of their difficulty detecting others' emotions. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Uono, Shota; Toichi, Motorni] Kyoto Univ, Fac Human Hlth Sci, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan.
   [Sato, Wataru] Kyoto Univ, Primate Res Inst, Hakubi Project, Inuyama, Aichi 4848506, Japan.
   [Toichi, Motorni] Org Promoting Dev Disorder Res, Sakyo Ku, Kyoto 6068392, Japan.
RP Uono, S (reprint author), Kyoto Univ, Fac Human Hlth Sci, Grad Sch Med, Sakyo Ku, 53 Shogoin Kawahara Cho, Kyoto 6068507, Japan.
EM uonoshota1982@gmail.com
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Ambadar Z, 2005, PSYCHOL SCI, V16, P403, DOI 10.1111/j.0956-7976.2005.01548.x
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
   Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019
   Azuma H, 1998, JAPANESE WECHSLER IN, V3rd
   Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
   Bould E, 2008, BRIT J PSYCHOL, V99, P167, DOI 10.1348/000712607X206702
   Bould E, 2008, COGNITION EMOTION, V22, P1569, DOI 10.1080/02699930801921156
   BRAVERMAN M, 1989, J AUTISM DEV DISORD, V19, P301, DOI 10.1007/BF02211848
   Calder AJ, 2001, NAT REV NEUROSCI, V2, P352, DOI 10.1038/35072584
   Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
   Catani M, 2002, NEUROIMAGE, V17, P77, DOI 10.1006/nimg.2002.1136
   Bird G, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.61
   Corona R, 1998, CHILD DEV, V69, P1494, DOI 10.1111/j.1467-8624.1998.tb06172.x
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Ekman P, 2003, EMOTIONS REVEALED
   Ekman P, 1975, UNMASKING FACE GUIDE
   FREYD JJ, 1984, J EXP PSYCHOL LEARN, V10, P126, DOI 10.1037/0278-7393.10.1.126
   Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
   Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218
   Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
   Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
   HUBBARD TL, 1990, MEM COGNITION, V18, P299, DOI 10.3758/BF03213883
   Hudson M, 2009, COGNITION, V112, P423, DOI 10.1016/j.cognition.2009.06.011
   Iacoboni M, 2005, CURR OPIN NEUROBIOL, V15, P632, DOI 10.1016/j.conb.2005.10.010
   Kessels RPC, 2010, TRANSL NEUROSCI, V1, P228, DOI 10.2478/v10134-010-0033-8
   Kirk RR, 1995, EXPT DESIGN PROCEDUR
   Kodama H., 1982, JAPANESE WECHSLER IN
   Koyama T, 2007, PSYCHIAT CLIN NEUROS, V61, P99, DOI 10.1111/j.1440-1819.2007.01617.x
   LaBar KS, 2003, CEREB CORTEX, V13, P1023, DOI 10.1093/cercor/13.10.1023
   MESIBOV GB, 1989, J AM ACAD CHILD PSY, V28, P538, DOI 10.1097/00004583-198907000-00012
   Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018
   Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401
   Motley M. T., 1988, W J SPEECH COMMUNICA, V52, P1
   Mukaida S., 2000, FOOLPROOF UTILITIES
   Niedenthal PM, 2001, COGNITION EMOTION, V15, P853
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
   Pelphrey KA, 2007, SOC COGN AFFECT NEUR, V2, P140, DOI 10.1093/scan/nsm010
   Rilling JK, 2008, NAT NEUROSCI, V11, P426, DOI 10.1038/nn2072
   Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P187, DOI 10.1007/s10803-006-0151-9
   Sato W, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-99
   Sato W, 2004, COGNITIVE BRAIN RES, V20, P81, DOI 10.1016/j.cogbrainres.2004.01.008
   Sato W, 2007, J NONVERBAL BEHAV, V31, P119, DOI 10.1007/s10919-007-0025-7
   Schopler R., 1986, CHILDHOOD AUTISM RAT
   Shinagawa F., 1990, JAPANESE WECHSLER AD
   SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
   Tardif C, 2007, J AUTISM DEV DISORD, V37, P1469, DOI 10.1007/s10803-006-0223-x
   Taylor NM, 2010, BRAIN COGNITION, V72, P464, DOI 10.1016/j.bandc.2010.01.003
   Thiebaut de Schotten M., 2011, NEUROIMAGE, V54, P49, DOI DOI 10.1016/J.NEUROIMAGE.2010.07.055
   Uono S, 2010, J AUTISM DEV DISORD, V40, P371, DOI 10.1007/s10803-009-0870-9
   Uono S, 2013, RES AUTISM SPECT DIS, V7, P361, DOI 10.1016/j.rasd.2012.10.007
   Uono S, 2011, SOC NEUROSCI-UK, V6, P452, DOI 10.1080/17470919.2011.605593
   Warren G, 2009, J NONVERBAL BEHAV, V33, P59, DOI 10.1007/s10919-008-0057-7
   YIRMIYA N, 1989, J CHILD PSYCHOL PSYC, V30, P725, DOI 10.1111/j.1469-7610.1989.tb00785.x
   Yoon KL, 2009, J ABNORM PSYCHOL, V118, P223, DOI 10.1037/a0014658
   Yoshikawa S, 2008, COGN AFFECT BEHAV NE, V8, P25, DOI 10.3758/CABN.8.1.25
NR 58
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1090
EP 1099
DI 10.1016/j.rasd.2014.05.018
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600011
ER

PT J
AU Nordahl-Hansen, A
   Kaale, A
   Ulvund, SE
AF Nordahl-Hansen, Anders
   Kaale, Anett
   Ulvund, Stein Erik
TI Language assessment in children with autism spectrum disorder:
   Concurrent validity between report-based assessments and direct tests
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Language assessment; ASD; Concurrent validity; Reynell Developmental
   Language Scales; Mullen Scales of Early Learning; Communicative
   Development Inventory
ID COMMUNICATIVE DEVELOPMENT INVENTORIES; PRESCHOOL-CHILDREN;
   YOUNG-CHILDREN; PREDICTIVE-VALIDITY; JOINT ATTENTION; MULLEN SCALES;
   COMPREHENSION; ABILITY; PARENT; SKILLS
AB Impairments in expressive and receptive language are common in individuals with autism spectrum disorder (ASD). Therefore, the importance of language assessment is emphasized in e.g. DSM-5. Thus, studies addressing the validity of different language measures are important. Parents and preschool teachers of 55 children diagnosed with childhood autism separately filled out the Communicative Development Inventory (CDI), a widely used report-based assessment of language. The children were also tested with the two standardized direct language tests: Reynell Developmental Language Scales (RDLS) and Mullen Scales of Early Learning (MSEL). Concurrent validity across the three measures was investigated. The results suggested very high agreement between the measures, and this was found regardless of whether parents or preschool teachers filled out the CDI. Given the difficulty in testing children with low language levels, as often is the case in young children with ASD, this study shows that several valid measures are available for measuring expressive and receptive language. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Nordahl-Hansen, Anders; Ulvund, Stein Erik] Univ Oslo, Dept Educ, N-0317 Oslo, Norway.
   [Kaale, Anett] Oslo Univ Hosp, Div Mental Hlth & Addict, N-0424 Oslo, Norway.
RP Nordahl-Hansen, A (reprint author), Univ Oslo, Dept Educ, POB 1092, N-0317 Oslo, Norway.
EM a.j.n.hansen@iped.uio.no
CR Akshoomoff N, 2006, CHILD NEUROPSYCHOL, V12, P269, DOI 10.1080/09297040500473714
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331
   Bornstein MH, 1998, CHILD DEV, V69, P654, DOI 10.2307/1132196
   Burns T. G., 2013, APPL NEUROPSYCHOL, V1, P33
   Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
   Charman T, 2004, J AUTISM DEV DISORD, V34, P59, DOI 10.1023/B:JADD.0000018075.77941.60
   Chiat S, 2007, J SPEECH LANG HEAR R, V50, P429, DOI 10.1044/1092-4388(2007/030)
   De Houwer A, 2005, J CHILD LANG, V32, P735, DOI 10.1017/S0305000905007026
   Dockrell J. E., 2001, CHILD PSYCHOL PSYCHI, V6, P74, DOI [10.1111/1475-3588.00325, DOI 10.1111/1475-3588.00325]
   Feldman HM, 2000, CHILD DEV, V71, P310, DOI 10.1111/1467-8624.00146
   Feldman HM, 2005, CHILD DEV, V76, P856, DOI 10.1111/j.1467-8624.2005.00882.x
   Fenson L, 1993, MACARTHUR COMMUNICAT
   Fenson L, 2007, MACARTHUR BATES COMM
   Hagtvet B., 1985, REYNELL SPRAKTEST
   Kaale A, 2012, J CHILD PSYCHOL PSYC, V53, P97, DOI 10.1111/j.1469-7610.2011.02450.x
   Kjellmer L, 2012, RES DEV DISABIL, V33, P172, DOI 10.1016/j.ridd.2011.09.003
   Kjellmer L, 2012, RES AUTISM SPECT DIS, V6, P1119, DOI 10.1016/j.rasd.2012.03.003
   Koegel LK, 1997, J AUTISM DEV DISORD, V27, P233, DOI 10.1023/A:1025894213424
   Law J, 2008, CHILD ADOL MENT H-UK, V13, P198, DOI 10.1111/j.1475-3588.2008.00503.x
   Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094
   Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
   Mayor J, 2011, DEVELOPMENTAL SCI, V14, P769, DOI 10.1111/j.1467-7687.2010.01024.x
   Miniscalco C, 2012, RES AUTISM SPECT DIS, V6, P204, DOI 10.1016/j.rasd.2011.05.001
   Mullen E., 1997, MULLEN SCALES EARLY
   Mullen E. M., 1989, INFANT MULLEN SCALES
   MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
   Nordahl-Hansen A, 2013, RES AUTISM SPECT DIS, V7, P1391, DOI 10.1016/j.rasd.2013.08.006
   Reynell J., 1990, REYNELL DEV LANGUAGE
   Reynell J., 1985, REYNELL DEV LANGUAGE
   Roberts JE, 1999, CHILD DEV, V70, P92, DOI 10.1111/1467-8624.00008
   Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
   Smith L., 1996, NORWEGIAN TRANSLATIO
   Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
   Thal D, 2007, AM J SPEECH-LANG PAT, V16, P54, DOI 10.1044/1058-0360(2007/007)
   TOMASELLO M, 1994, MONOGR SOC RES CHILD, V59, P174
   Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
NR 37
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1100
EP 1106
DI 10.1016/j.rasd.2014.05.017
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600012
ER

PT J
AU King, ML
   Takeguchi, K
   Barry, SE
   Rehfeldt, RA
   Boyer, VE
   Mathews, TL
AF King, Melissa L.
   Takeguchi, Kazu
   Barry, Shaina E.
   Rehfeldt, Ruth Anne
   Boyer, Valerie E.
   Mathews, Therese L.
TI Evaluation of the iPad in the acquisition of requesting skills for
   children with autism spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Requesting skills; iPad (R); Picture-based communication system
ID EXCHANGE COMMUNICATION-SYSTEM; VOICE OUTPUT COMMUNICATION;
   SPEECH-GENERATING DEVICE; DEVELOPMENTAL-DISABILITIES; PECS
AB The iPad (R) with the Proloquo2Go (TM) application is designed to function as a speech-generating device (SGD). This study evaluates whether children with autism spectrum disorder (ASD) can acquire requesting skills using the iPad (R) with the Proloquo2Go (TM) application. Participants included three children with ASD between the ages of three and five. A multiple probe design across participants was used. Intervention phases were adapted and modified from the picture exchange communication system (PECS) (Bondy & Frost, 1994; Frost & Bondy, 2002). Results of this study support that children diagnosed with ASD can acquire skills needed to request preferred items using the iPad (R) with the Proloquo2Go (TM) application with training of a picture-based communication system. In addition, vocal requesting increased for the participants during the training phases in comparison to baseline probes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [King, Melissa L.; Takeguchi, Kazu; Barry, Shaina E.; Rehfeldt, Ruth Anne; Boyer, Valerie E.] So Illinois Univ, Carbondale, IL 62901 USA.
   [Mathews, Therese L.] Univ Nebraska, Med Ctr, Munroe Meyer Inst, Lincoln, NE 68583 USA.
RP King, ML (reprint author), So Illinois Univ, Carbondale, IL 62901 USA.
EM melissa.king@unmc.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Barlow D.H., 2009, AUGMENTATIVE ALTERNA
   Boesch MC, 2013, RES AUTISM SPECT DIS, V7, P480, DOI 10.1016/j.rasd.2012.12.002
   Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
   Chambers M, 2003, RES DEV DISABIL, V24, P265, DOI 10.1016/S0891-4222(03)00042-8
   Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213
   FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
   Fisher WW, 1996, AM J MENT RETARD, V101, P15
   Flores M, 2012, AUGMENT ALTERN COMM, V28, P74, DOI 10.3109/07434618.2011.644579
   Franco JH, 2009, FOCUS AUTISM DEV DIS, V24, P146, DOI 10.1177/1088357609338380
   Frost L., 2002, PICTURE EXCHANGE COM, V2nd
   Ganz JB, 2004, J AUTISM DEV DISORD, V34, P395, DOI 10.1023/B:JADD.0000037416.59095.d7
   HORNER RD, 1978, J APPL BEHAV ANAL, V11, P189, DOI 10.1901/jaba.1978.11-189
   Kagohara DM, 2013, RES DEV DISABIL, V34, P147, DOI 10.1016/j.ridd.2012.07.027
   Kazdin A. E., 1982, SINGLE CASE RES DESI
   Kratochwill T. R., 2010, SINGLE CASE DESIGNS
   Kravits TR, 2002, J AUTISM DEV DISORD, V32, P225, DOI 10.1023/A:1015457931788
   Liddle K, 2001, INT J LANG COMM DIS, V36, P391
   Lorah ER, 2013, J DEV PHYS DISABIL, V25, P637, DOI 10.1007/s10882-013-9337-1
   National Research Council, 2001, ED CHILDR AUT
   Proloquo2Go, ACC YOUR POCK ASS WA
   Romski M. A., 1996, BREAKING SPEECH BARR
   Schepis MM, 1998, J APPL BEHAV ANAL, V31, P561, DOI 10.1901/jaba.1998.31-561
   Schepis MM, 1996, BEHAV MODIF, V20, P451, DOI 10.1177/01454455960204005
   Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
   Sulzer-Azaroff B, 2009, FOCUS AUTISM DEV DIS, V24, P89, DOI 10.1177/1088357609332743
   Thunberg G, 2009, FOCUS AUTISM DEV DIS, V24, P104, DOI 10.1177/1088357608329228
   Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
   Wodka E. L., 2013, PEDIATRICS, V131, pe1128
NR 29
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1107
EP 1120
DI 10.1016/j.rasd.2014.05.011
PG 14
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600013
ER

PT J
AU Hill, AP
   Zuckerman, KE
   Hagen, AD
   Kriz, DJ
   Duvall, SW
   Van Santen, J
   Nigg, J
   Fair, D
   Fombonne, E
AF Hill, Alison Presmanes
   Zuckerman, Katharine E.
   Hagen, Arlene D.
   Kriz, Daniel J.
   Duvall, Susanne W.
   Van Santen, Jan
   Nigg, Joel
   Fair, Damien
   Fombonne, Eric
TI Aggressive behavior problems in children with autism spectrum disorders:
   Prevalence and correlates in a large clinical sample
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Psychotropic drugs; Aggression; Sleep;
   Internalizing problems; Attention problems
ID CHALLENGING BEHAVIORS; PHYSICAL AGGRESSION; EARLY-CHILDHOOD;
   INTELLECTUAL DISABILITIES; LANGUAGE IMPAIRMENT; YOUNG-PEOPLE;
   RISK-FACTORS; TRAJECTORIES; SYMPTOMS; TODDLERS
AB Aggressive behavior problems (ABP) are frequent yet poorly understood in children with autism spectrum disorders (ASD) and are likely to co-vary significantly with comorbid problems. We examined the prevalence and sociodemographic correlates of ABP in a clinical sample of children with ASD (N = 400; 2-16.9 years). We also investigated whether children with ABP experience more intensive medical interventions, greater impairments in behavioral functioning, and more severe comorbid problems than children with ASD who do not have ABP. One in four children with ASD had Child Behavior Checklist scores on the Aggressive Behavior scale in the clinical range (T-scores >= 70). Sociodemographic factors (age, gender, parent education, race, ethnicity) were unrelated to ABP status. The presence of ABP was significantly associated with increased use of psychotropic drugs and melatonin, lower cognitive functioning, lower ASD severity, and greater comorbid sleep, internalizing, and attention problems. In multivariate models, sleep, internalizing, and attention problems were most strongly associated with ABP. These comorbid problems may hold promise as targets for treatment to decrease aggressive behavior and proactively identify high-risk profiles for prevention. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Hill, Alison Presmanes; Van Santen, Jan] Oregon Hlth & Sci Univ, Dept Pediat, Ctr Spoken Language Understanding, Portland, OR 97239 USA.
   [Hill, Alison Presmanes; Hagen, Arlene D.; Kriz, Daniel J.; Duvall, Susanne W.; Van Santen, Jan; Fombonne, Eric] Oregon Hlth & Sci Univ, Inst Dev & Disabil, Portland, OR 97239 USA.
   [Zuckerman, Katharine E.] Oregon Hlth & Sci Univ, Dept Pediat, Div Gen Pediat, Portland, OR 97239 USA.
   [Zuckerman, Katharine E.] Oregon Hlth & Sci Univ, Dept Pediat, Child & Adolescent Hlth Measurement Initiat, Portland, OR 97239 USA.
   [Hagen, Arlene D.; Nigg, Joel; Fair, Damien] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA.
   [Fair, Damien; Fombonne, Eric] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA.
RP Hill, AP (reprint author), 3181 Southwest Sam Jackson Pk Rd GH 40, Portland, OR 97239 USA.
EM hillali@ohsu.edu
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
   Achenbach T. M., 2001, MANUAL ASEBA SCHOOL
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331
   Broidy LM, 2003, DEV PSYCHOL, V39, P222, DOI 10.1037/0012-1649.39.2.222
   Bronsard G, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014358
   Bryman A., 2001, QUANTITAIVE DAT ANAL
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Card NA, 2008, CHILD DEV, V79, P1185, DOI 10.1111/j.1467-8624.2008.01184.x
   Cervantes P, 2013, RES AUTISM SPECT DIS, V7, P1528, DOI 10.1016/j.rasd.2013.09.005
   Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Deprey L., 2009, ASSESSMENT AUTISM SP, P290
   Dionne G, 2003, DEV PSYCHOL, V39, P261, DOI 10.1037/0012-1649.39.2.261
   Dominick KC, 2007, RES DEV DISABIL, V28, P145, DOI 10.1016/j.ridd.2006.02.003
   Estes AM, 2007, AM J MENT RETARD, V112, P439, DOI 10.1352/0895-8017(2007)112[439:LOIFPP]2.0.CO;2
   Farmer C., 2014, AUTISM
   Farmer CA, 2011, RES AUTISM SPECT DIS, V5, P317, DOI 10.1016/j.rasd.2010.04.014
   Field A., 2012, DISCOVERING STAT USI
   Gelman A., 2007, DATA ANAL USING REGR, P529
   Georgiades S, 2011, J AUTISM DEV DISORD, V41, P1321, DOI 10.1007/s10803-010-1158-9
   Goldman SE, 2012, J AUTISM DEV DISORD, V42, P531, DOI 10.1007/s10803-011-1270-5
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Gross HE, 2008, J ABNORM CHILD PSYCH, V36, P693, DOI 10.1007/s10802-008-9224-x
   Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
   Hodgetts S, 2013, FOCUS AUTISM DEV DIS, V28, P166, DOI 10.1177/1088357612472932
   Hus V., 2012, J AUTISM DEV DISORDE
   Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
   Jang JN, 2011, RES AUTISM SPECT DIS, V5, P1028, DOI 10.1016/j.rasd.2010.11.008
   Jester JM, 2005, DEV PSYCHOPATHOL, V17, P99, DOI 10.1017/S0954579405050066
   Kanne S. M., 2010, J AUTISM DEV DISORD, V41, P1007
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
   Klin A., 2007, J AUTISM DEV DISORD, V37, P748, DOI DOI 10.1007/S10803-006-0229-4
   Kozlowski AM, 2012, RES AUTISM SPECT DIS, V6, P958, DOI 10.1016/j.rasd.2011.12.011
   Lansford JE, 2006, DEV PSYCHOPATHOL, V18, P35, DOI 10.1017/S0954579406060032
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Ligthart L, 2005, TWIN RES HUM GENET, V8, P483, DOI 10.1375/183242705774310169
   LITTLE RJA, 1988, J AM STAT ASSOC, V83, P1198, DOI 10.2307/2290157
   Lord C., 2000, J AUTISM DEV DISORDE
   Malow BA, 2006, SLEEP, V29, P1563
   Mandell DS, 2008, J AUTISM DEV DISORD, V38, P1059, DOI 10.1007/s10803-007-0481-2
   Maskey M, 2013, J AUTISM DEV DISORD, V43, P851, DOI 10.1007/s10803-012-1622-9
   Matson J. L., 2001, RES DEV DISABILITIES
   Matson JL, 2010, DEV NEUROREHABIL, V13, P164, DOI 10.3109/17518420903270683
   Matson JL, 2011, DEV NEUROREHABIL, V14, P129, DOI 10.3109/17518423.2011.557029
   Mayes SD, 2009, RES AUTISM SPECT DIS, V3, P931, DOI 10.1016/j.rasd.2009.04.002
   Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P1, DOI 10.1016/j.rasd.2011.08.001
   Mazurek MO, 2013, RES AUTISM SPECT DIS, V7, P455, DOI 10.1016/j.rasd.2012.11.004
   McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
   McTiernan A, 2011, RES AUTISM SPECT DIS, V5, P1215, DOI 10.1016/j.rasd.2011.01.009
   Medeiros K, 2012, RES DEV DISABIL, V33, P1110, DOI 10.1016/j.ridd.2012.02.005
   Mullen E, 1995, MULLEN SCALES EARLY
   Murphy GH, 2005, J AUTISM DEV DISORD, V35, P405, DOI 10.1007/s10803-005-5030-2
   Murphy O, 2009, RES AUTISM SPECT DIS, V3, P474, DOI 10.1016/j.rasd.2008.09.008
   Nagin D, 1999, CHILD DEV, V70, P1181, DOI 10.1111/1467-8624.00086
   Nagin DS, 2001, ARCH GEN PSYCHIAT, V58, P389, DOI 10.1001/archpsyc.58.4.389
   NICHD Early Child Care Research Network, 2004, MONOGRAPHS SOC RES C, V69, P1, DOI DOI 10.1007/S12103-010-9074-2
   Owens JA, 2000, SLEEP, V23, P1043
   Roid G. H., 2003, STANFORD BINET INTEL
   Seguin JR, 2009, J CHILD PSYCHOL PSYC, V50, P679, DOI 10.1111/j.1469-7610.2008.02030.x
   Sikora DM, 2008, J AUTISM DEV DISORD, V38, P440, DOI 10.1007/s10803-007-0407-z
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Tremblay RE, 2000, INT J BEHAV DEV, V24, P129
   Tremblay RE, 2004, PEDIATRICS, V114, pE43, DOI 10.1542/peds.114.1.e43
   Tureck K, 2013, RES AUTISM SPECT DIS, V7, P1377, DOI 10.1016/j.rasd.2013.08.003
   van Belle G., 2004, BIOSTATISTICS
   van Daal J, 2007, J CHILD PSYCHOL PSYC, V48, P1139, DOI 10.1111/j.1469-7610.2007.01790.x
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Witwer A, 2005, J CHILD ADOL PSYCHOP, V15, P671, DOI 10.1089/cap.2005.15.671
   Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
NR 73
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1121
EP 1133
DI 10.1016/j.rasd.2014.05.006
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600014
ER

PT J
AU Rahbar, MH
   Samms-Vaughan, M
   Dickerson, AS
   Loveland, KA
   Ardjomand-Hessabi, M
   Bressler, J
   Lee, M
   Shakespeare-Pellington, S
   Grove, ML
   Pearson, DA
   Boervvinkle, E
AF Rahbar, Mohammad H.
   Samms-Vaughan, Maureen
   Dickerson, Aisha S.
   Loveland, Katherine A.
   Ardjomand-Hessabi, Manouchehr
   Bressler, Jan
   Lee, MinJae
   Shakespeare-Pellington, Sydonnie
   Grove, Megan L.
   Pearson, Deborah A.
   Boervvinkle, Eric
TI Role of fruits, grains, and seafood consumption in blood cadmium
   concentrations of Jamaican children with and without Autism Spectrum
   Disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Cadmium; Autism Spectrum Disorder; Grains; Fruits; Seafood; Jamaica
ID FISH CONSUMPTION; HEAVY-METALS; QUANTILE REGRESSION; CHILDHOOD AUTISM;
   EXPOSURE; POPULATION; HAIR; LEAD; ACCUMULATION; ENVIRONMENT
AB Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case-control pairs (220 children) ages 2-8 years in Kingston, Jamaica, we compared the 75th percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). In both univariable and multivariable Quantile Regression Models that controlled for potential confounding factors, we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations (P > 0.22). However, we found a significantly higher 75th percentile of blood cadmium concentrations in TD Jamaican children who consumed shellfish (lobsters, crabs) (P < 0.05), fried plantain (P < 0.01), and boiled dumpling (P < 0.01). We also observed that children living in Jamaica have an arithmetic mean blood cadmium concentration of 0.16 mu g/L which is similar to that of the children in developed countries and much lower than that of children in developing countries. Although our results do not support an association between blood cadmium concentrations and ASD, to our knowledge, this study is the first to report levels of blood cadmium in TD children as well as those with ASD in Jamaica. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Rahbar, Mohammad H.; Dickerson, Aisha S.; Boervvinkle, Eric] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci EHGES, Houston, TX 77030 USA.
   [Rahbar, Mohammad H.; Lee, MinJae] Univ Texas Hlth Sci Ctr Houston, Dept Internal Med, Univ Texas Med Sch, Div Clin & Translat Sci, Houston, TX 77030 USA.
   [Rahbar, Mohammad H.; Dickerson, Aisha S.; Ardjomand-Hessabi, Manouchehr] Univ Texas Hlth Sci Ctr Houston, CCTS, BERD, Houston, TX 77030 USA.
   [Shakespeare-Pellington, Sydonnie] Univ W Indies, Dept Child & Adolescent Hlth, Kingston 7, Jamaica.
   [Loveland, Katherine A.; Pearson, Deborah A.] Univ Texas Hlth Sci Ctr Houston, Univ Texas Med Sch, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Boervvinkle, Eric] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.
RP Rahbar, MH (reprint author), Univ Texas Hlth Sci Ctr Houston, Ctr Clin & Translat Sci, 6410 Fannin St,UT Professional Bldg Suite 1100-05, Houston, TX 77030 USA.
EM Mohammad.H.Rahbar@uth.tmc.edu; msammsvaughan@gmail.com;
   Aisha.S.Dickerson@uth.tmc.edu; Katherine.A.Loveland@uth.tmc.edu;
   Manouchehr.A.Hessabi@uth.tmc.edu; Jan.Bressler@uth.tmc.edu;
   MinJae.Lee@uth.tmc.edu; sydonniesp@gmail.com; Megan.L.Grove@uth.tmc.edu;
   Deborah.A.Pearson@uth.tmc.edu; Eric.Boerwinkle@uth.tmc.edu
CR Adams JB, 2013, BIOL TRACE ELEM RES, V151, P171, DOI 10.1007/s12011-012-9551-1
   Agency for Toxic Substances and Disease Registry (ATSDR), 2008, TOX PROF CADM
   Albizzati A, 2012, MINERVA PEDIATR, V64, P27
   Bottai M, 2010, STAT MED, V29, P309, DOI 10.1002/sim.3781
   Cao Y, 2009, ENVIRON HEALTH PERSP, V117, P1580, DOI 10.1289/ehp.0900765
   CAPEL ID, 1981, CLIN CHEM, V27, P879
   Cheng S. F., 2006, INT J APPL SCI ENG, V3, P243
   Cheng S F, 2007, J ENV ENG MANAGEMENT, V17, P137
   Ciesielski T., 2008, EPIDEMIOLOGY, V19
   Copes R, 2008, ENVIRON RES, V107, P160, DOI 10.1016/j.envres.2008.01.014
   DESILVA PE, 1981, BRIT J IND MED, V38, P76
   De Gieter M, 2002, ARCH ENVIRON CON TOX, V43, P406, DOI 10.1007/s00244-002-1193-4
   De Palma G, 2012, J AUTISM DEV DISORD, V42, P342, DOI 10.1007/s10803-011-1245-6
   Eilers PHC, 2012, BMC IMMUNOL, V13, DOI 10.1186/1471-2172-13-37
   Gale CR, 2009, J CHILD PSYCHOL PSYC, V50, P816, DOI 10.1111/j.1469-7610.2008.02029.x
   Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
   Genuis SJ, 2009, ACTA PAEDIATR, V98, P1575, DOI 10.1111/j.1651-2227.2009.01495.x
   Geschwind DH, 2013, INT M AUT RES IMFAR
   Ginsberg GL, 2009, ENVIRON HEALTH PERSP, V117, P267, DOI 10.1289/ehp.11368
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hertz-Picciotto I, 2013, INT M AUT RES IMFAR
   Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
   Howe A, 2005, ENVIRON GEOCHEM HLTH, V27, P19, DOI 10.1007/s10653-004-5671-7
   Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
   Jarup L, 2009, TOXICOL APPL PHARM, V238, P201, DOI 10.1016/j.taap.2009.04.020
   JIANG HM, 1990, CHINESE MED J-PEKING, V103, P331
   JUNG K, 1993, CLIN CHEM, V39, P757
   Kawada T, 1998, J OCCUP HEALTH, V40, P264, DOI 10.1539/joh.40.264
   Kawasaki T, 2004, TOXICOL IND HEALTH, V20, P51, DOI 10.1191/0748233704th189oa
   Kern JK, 2007, J TOXICOL ENV HEAL A, V70, P715, DOI 10.1080/15287390601188060
   Kippler M, 2012, ENVIRON HEALTH PERSP, V120, P284, DOI 10.1289/ehp.1103711
   Kippler M, 2010, TOXICOL LETT, V198, P20, DOI 10.1016/j.toxlet.2010.04.029
   Knight C, 1997, ENVIRON GEOCHEM HLTH, V19, P63, DOI 10.1023/A:1018442219943
   Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
   Lalor GC, 2008, SCI TOTAL ENVIRON, V400, P162, DOI 10.1016/j.scitotenv.2008.07.011
   Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
   Linderholm L, 2011, J ENVIRON MONITOR, V13, P2728, DOI 10.1039/c1em10480b
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Maclean C H, 2005, Evid Rep Technol Assess (Summ), P1
   MARLOWE M, 1983, AM J MENT DEF, V87, P477
   Mulligan A, 2009, IRISH J MED SCI, V178, P193, DOI 10.1007/s11845-008-0184-5
   Nawrot TS, 2010, BIOMETALS, V23, P769, DOI 10.1007/s10534-010-9343-z
   Oken E, 2005, ENVIRON HEALTH PERSP, V113, P1376, DOI 10.1289/ehp.8041
   Palmer RF, 2010, PEDIATRICS, V126
   Rahbar MH, 2013, NEUROTOX RES, V23, P22, DOI 10.1007/s12640-012-9321-z
   Rahbar MH, 2012, SCI TOTAL ENVIRON, V433, P362, DOI 10.1016/j.scitotenv.2012.06.085
   Rahbar MH, 2012, J AUTISM DEV DISORD, V42, P1928, DOI 10.1007/s10803-011-1438-z
   Rutter M., 2003, SCQ SOCIAL COMMUNICA
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   SAS Institute, 2011, SAS 9 3 COMP SOFTW
   Schoeters G, 2006, ACTA PAEDIATR, V95, P50, DOI 10.1080/08035320600886232
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Sirot V, 2008, J EXPO SCI ENV EPID, V18, P400, DOI 10.1038/sj.jes.7500615
   Stern AH, 2011, ENVIRON HEALTH PERSP, V119, P1043, DOI [10.1289/ehp.1002824, 10.1289/ehp1002824]
   Szkup-Jablonska M, 2012, ANN AGR ENV MED, V19, P241
   THATCHER RW, 1982, ARCH ENVIRON HEALTH, V37, P159
   Verma P, 2007, APPL MATH MODEL, V31, P1652, DOI 10.1016/j.apm.2006.05.008
   Volk HE, 2013, JAMA PSYCHIAT, V70, P71, DOI 10.1001/jamapsychiatry.2013.266
   Volkmar FR, 2008, WORLD PSYCHIATRY, V7, P19
   WHO & International Programme on Chemical Safety (IPCS), 2006, CADMIUM, V134
   WHO, 2011, CADM DRINK WAT BACKG
   WHO & International Agency for Research on Cancer (IARC), 1997, IARC MON EV CARC RIS, V58
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Wong Suzy L, 2008, Health Rep, V19, P31
   Wright PRD, 2010, ENVIRON GEOCHEM HLTH, V32, P567, DOI 10.1007/s10653-010-9318-6
   Wright RO, 2006, NEUROTOXICOLOGY, V27, P210, DOI 10.1016/j.neuro.2005.10.001
   Yorbik O, 2010, BIOL TRACE ELEM RES, V135, P10, DOI 10.1007/s12011-009-8494-7
   Zheng LK, 2008, ENVIRON RES, V108, P15, DOI 10.1016/j.envres.2008.04.002
NR 68
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1134
EP 1145
DI 10.1016/j.rasd.2014.06.002
PG 12
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600015
ER

PT J
AU Lacroix, A
   Guidetti, M
   Roe, B
   Reilly, J
AF Lacroix, Agnes
   Guidetti, Michele
   Roge, Bernadette
   Reilly, Judy
TI Facial emotion recognition in 4-to 8-year-olds with autism spectrum
   disorder: A developmental trajectory approach
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Emotion recognition; Developmental delay
ID CHILDREN; EXPRESSIONS; FACES; PERCEPTION; VOICES; PEOPLE
AB The investigation of emotion recognition in autism spectrum disorder (ASD) has both theoretical and practical implications. However, although many studies have examined facial emotion recognition in ASD, some points remain unclear. We therefore studied facial emotion recognition in young children with ASD across a small age range, in order to determine (1) their ability to recognize emotion and (2) the developmental trajectory of this ability. Twenty-two children with ASD aged 4-8 years were compared with typically developing children matched on either chronological age or verbal mental age. We administered three facial emotion tasks: matching, identification, and labeling. Results showed that children with ASD and typically developing children had difficulty with labeling emotions, but not with matching or identifying them. Happiness was the easiest to recognize, and surprise the hardest. The children with ASD did not exhibit delayed onset in the development of facial emotion recognition. To conclude, emotion recognition difficulties in children with ASD primarily concern the recognition of negative emotions and the identification of surprise, as they do in TD groups. This should be taken into account in future research, as well as in the design of future intervention programs. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lacroix, Agnes] Univ Rennes 2, Ctr Rech Psychol Cognit & Commun, EA 1285, F-35000 Rennes, France.
   [Guidetti, Michele] Univ Toulouse 2, Octogone ECCD, Unite Rech Interdisciplinaire, EA 4156, F-31058 Toulouse 09, France.
   [Roge, Bernadette] Univ Toulouse 2, Octogone CERPP, Unite Rech Interdisciplinaire ea 4156, F-31058 Toulouse 9, France.
   [Reilly, Judy] San Diego State Univ, San Diego, CA 92182 USA.
RP Lacroix, A (reprint author), Univ Rennes 2, Ctr Rech Psychol Cognit & Commun, EA 1285, Pl Recteur Henri Moal, F-35000 Rennes, France.
EM agnes.lacroix@univ-rennes2.fr; guidetti@univ-tIse2.fr;
   roge@univ-tIse2.fr; reillyl@mail.sdsu.edu
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Baron-Cohen S, 1993, UNDERSTANDING OTHER
   BARONCOHEN S, 1993, COGNITION EMOTION, V7, P507, DOI 10.1080/02699939308409202
   BARONCOHEN S, 1991, CHILD DEV, V62, P385, DOI 10.1111/j.1467-8624.1991.tb01539.x
   CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
   Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
   Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
   Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
   Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
   Delaunay-El Allam M, 2011, APPL PSYCHOLINGUIST, V32, P781, DOI 10.1017/S0142716411000063
   Ekman P., 2002, FACIAL ACTION CODING
   Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   HOBSON RP, 1988, PSYCHOL MED, V18, P911
   HOBSON RP, 1989, BRIT J DEV PSYCHOL, V7, P237
   HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   Lacroix A, 2009, RES DEV DISABIL, V30, P976, DOI 10.1016/j.ridd.2009.02.002
   Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   LOVELAND KA, 1995, DEV PSYCHOPATHOL, V7, P409
   OZONOFF S, 1990, J CHILD PSYCHOL PSYC, V31, P343, DOI 10.1111/j.1469-7610.1990.tb01574.x
   Reilly J., 2006, SANAFE UNPUB
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
   TEUNISSE JP, 1994, INT J NEUROSCI, V77, P1
   Thommen E., 2010, ENFANCE, V3, P319
   Uono S, 2011, SOC NEUROSCI-UK, V6, P452, DOI 10.1080/17470919.2011.605593
   Vicari S, 2000, ACTA PAEDIATR, V89, P836, DOI 10.1080/080352500750043756
   Williams B. T., 2012, AUTISM, V17, P762
   YIRMIYA N, 1992, CHILD DEV, V63, P150, DOI 10.1111/j.1467-8624.1992.tb03603.x
NR 31
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1146
EP 1154
DI 10.1016/j.rasd.2014.05.012
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600016
ER

PT J
AU Zeedyk, SM
   Rodriguez, G
   Tipton, LA
   Baker, BL
   Blocher, J
AF Zeedyk, S. M.
   Rodriguez, G.
   Tipton, L. A.
   Baker, B. L.
   Blocher, J.
TI Bullying of youth with autism spectrum disorder, intellectual
   disability, or typical development: Victim and parent perspectives
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Intellectual disability; Bullying; Adolescents; Friendship
ID HIGH-FUNCTIONING AUTISM; SOCIAL-SKILLS; ADOLESCENTS; FRIENDSHIP;
   CHILDREN; PREVALENCE; SCHOOL; LONELINESS; VICTIMIZATION; ADJUSTMENT
AB In-depth interviews conducted separately with 13-year-olds with autism spectrum disorder (ASD), intellectual disability (ID), or typical development (TD) and their mothers investigated the experiences of victimization in the form of bullying. Coded constructs from the interviews were utilized to compare groups on the frequency, type, and impact of victimization. Youth with ASD were victimized more frequently than their ID or TO peers, and the groups differed with regard to the type of bullying and the impact it had, with ASD youth faring the worst. Higher internalizing problems and conflict in friendships were found to be significant predictors of victimization, according to both youth- and mother-reports. These predictors were found to be more salient than ASD status alone. Implications for practice are discussed. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Zeedyk, S. M.; Rodriguez, G.; Tipton, L. A.; Blocher, J.] Univ Calif Riverside, Grad Sch Educ, Attn SEARCH Ctr, Riverside, CA 92521 USA.
   Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
RP Zeedyk, SM (reprint author), Univ Calif Riverside, Grad Sch Educ, Attn SEARCH Ctr, Riverside, CA 92521 USA.
EM szeed001@ucr.edu; geovanna.rodriguez@ucr.edu; Itipt001@ucr.edu;
   baker@psych.ucla.edu; jan.blacher@ucr.edu
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Asperger H., 1944, AUTISM ASPERGER SYND
   Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
   Bauminger N, 2010, AUTISM RES, V3, P101, DOI 10.1002/aur.131
   Blake J. J., 2012, SCHOOL PSYCHOL QUART, V27, P2100
   Bowker JCW, 2006, MERRILL PALMER QUART, V52, P671, DOI 10.1353/mpq.2006.0000
   Cappadocia MC, 2012, J AUTISM DEV DISORD, V42, P266, DOI 10.1007/s10803-011-1241-x
   Carlyle KE, 2007, J SCHOOL HEALTH, V77, P623, DOI 10.1111/j.1746-1561.2007.00242.x
   Centers for Disease Control and Prevention (CDC), 2012, AUT SPECTR DIS ASDS
   Christensen LL, 2012, J MENT HEALTH RES IN, V5, P49, DOI 10.1080/19315864.2011.637660
   Fenning RM, 2007, AM J MENT RETARD, V112, P107, DOI 10.1352/0895-8017(2007)112[107:PCWBIF]2.0.CO;2
   Gresham FM, 1990, MANUAL SOCIAL SKILLS
   Heiman T., 2000, SCHOOL PSYCHOL INT, V21, P330
   Hillier A., 2007, FOCUS AUTISM OTHER D, V22, P107, DOI DOI 10.1177/10883576070220020201
   Hillier AJ, 2011, J DEV PHYS DISABIL, V23, P267, DOI 10.1007/s10882-011-9226-4
   Hodges EVE, 1999, DEV PSYCHOL, V35, P94, DOI 10.1037/0012-1649.33.6.1032
   Holt MK, 2007, J YOUTH ADOLESCENCE, V36, P984, DOI 10.1007/s10964-006-9153-3
   Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   IBM Corp, 2013, IBM SPSS STAT WIND V
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Larkin P, 2012, J APPL RES INTELLECT, V25, P29, DOI 10.1111/j.1468-3148.2011.00652.x
   Laugeson E. A., 2013, SCI MAKING FRIENDS H
   Laugeson EA, 2012, J AUTISM DEV DISORD, V42, P1025, DOI 10.1007/s10803-011-1339-1
   Learner M. D., 2011, AUTISM, V15, P21
   Locke J., 2010, J RES SPECIAL ED NEE, V10, P74, DOI DOI 10.1111/J.1471-3802.2010.01148.X
   Matheson C, 2007, AM J MENT RETARD, V112, P319, DOI 10.1352/0895-8017(2007)112[0319:AGFIHT]2.0.CO;2
   Mayes SD, 2011, J DEV PHYS DISABIL, V23, P325, DOI 10.1007/s10882-011-9231-7
   Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
   McVilly KR, 2006, J APPL RES INTELLECT, V19, P191, DOI 10.1111/j.1468-3148.2005.00261.x
   Nansel TR, 2001, JAMA-J AM MED ASSOC, V285, P2094, DOI 10.1001/jama.285.16.2094
   National Center for Educational Statistics U.S. Department of Education, 2011, 2011336 NCES US DEP
   OLWEUS D, 1994, J CHILD PSYCHOL PSYC, V35, P1171, DOI 10.1111/j.1469-7610.1994.tb01229.x
   Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
   Raykov T., 2008, INTRO APPL MULTIVARI
   Reiter S, 2007, INTELLECT DEV DISAB, V45, P174, DOI 10.1352/1934-9556(2007)45[174:BASESW]2.0.CO;2
   Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
   Rowley E, 2012, RES AUTISM SPECT DIS, V6, P1126, DOI 10.1016/j.rasd.2012.03.004
   Rubin K, 2008, SOC DEV, V17, P1085, DOI 10.1111/j.1467-9507.2007.00445.x
   Rubin KH, 2006, J ABNORM CHILD PSYCH, V34, P143, DOI 10.1007/s10802-005-9017-4
   Satler J. M., 2004, ASSESSMENT CHILDREN
   Schmidt ME, 2007, MERRILL PALMER QUART, V53, P439, DOI 10.1353/mpq.2007.0021
   Seltzer MM, 2004, J AUTISM DEV DISORD, V34, P41, DOI 10.1023/B:JADD.0000018073.92982.64
   Solish A, 2010, J APPL RES INTELLECT, V23, P226, DOI 10.1111/j.1468-3148.2009.00525.x
   Sparrow S. S., 2005, VINELAND SCALES ADAP
   Tipton LA, 2013, J APPL RES INTELLECT, V26, P522, DOI 10.1111/jar.12051
   Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
   van Roekel E, 2010, J AUTISM DEV DISORD, V40, P63, DOI 10.1007/s10803-009-0832-2
   Wainscot J. J., 2008, INT J PSYCHOL PSYCHO, V8, P25
   Wechsler D., 2003, WECHSLER INTELLIGENC
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   White SW, 2010, FOCUS AUTISM DEV DIS, V25, P209, DOI 10.1177/1088357610380595
   Whitehouse AJO, 2009, J ADOLESCENCE, V32, P309, DOI 10.1016/j.adolescence.2008.03.004
NR 54
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1173
EP 1183
DI 10.1016/j.rasd.2014.06.001
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600018
ER

PT J
AU Bardikoff, N
   McGonigle-Chalmers, M
AF Bardikoff, Nicole
   McGonigle-Chalmers, Margaret
TI Testing nonverbal IQ in children with Autism Spectrum Disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE WISC-III; WISC-IV; KABC-II; Nonverbal IQ; Children with Autism; Spectrum
   Disorders
ID HIGH-FUNCTIONING AUTISM; WECHSLER INTELLIGENCE SCALE; PROCESSING SPEED;
   MATCHING STRATEGIES; ASPERGERS-SYNDROME; WISC-III; PROFILES; IV;
   INDIVIDUALS; ABILITIES
AB 15 high-functioning school aged children with ASD and 15 neurotypically developing age matched controls were assessed using the WISC-IV and the KABC-II in order to assess whether the WISC-IV has rectified problems associated with the WISC-III's undue emphasis on timing measures. No significant group differences were found for the PRI sub-scale of the WISC-IV nor for the nonverbal scale of the KABC-II, but the ASD group scored significantly lower than controls on the Processing Speed Index of the WISC-IV. This supports the need to isolate of timing criteria when IQ testing in populations with ASD, as is now the case with the WISC-IV. However significantly higher scores were obtained for the KABC-II versus the PRI for children with ASD only. The reasons for this are discussed with regard to a possible cultural bias in the Picture Concepts subtest of the WISC-IV. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Bardikoff, Nicole; McGonigle-Chalmers, Margaret] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9QU, Midlothian, Scotland.
RP Bardikoff, N (reprint author), Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9QU, Midlothian, Scotland.
EM n.bardikoff@ed-alumni.net; 12nb42@queensu.ca
CR ALLEN MH, 1991, J AUTISM DEV DISORD, V21, P483, DOI 10.1007/BF02206872
   Black DO, 2009, J AUTISM DEV DISORD, V39, P1613, DOI 10.1007/s10803-009-0795-3
   Bolte S, 2009, J AUTISM DEV DISORD, V39, P678, DOI 10.1007/s10803-008-0667-2
   Burack JA, 2004, J AUTISM DEV DISORD, V34, P65, DOI 10.1023/B:JADD.0000018076.90715.00
   Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   Flanagan D. P., 2009, ESSENTIAL WISC 4 ASS
   Goldstein G, 2008, NEUROPSYCHOLOGY, V22, P301, DOI 10.1037/0894-4105.22.3.301
   Goldstein G, 2001, J AUTISM DEV DISORD, V31, P433, DOI 10.1023/A:1010620820786
   Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
   Jarrold C, 2004, J AUTISM DEV DISORD, V34, P81, DOI 10.1023/B:JADD.0000018078.82542.ab
   Kaufman A. S., 2004, KAUFMAN ASSESSMENT B
   Keith TZ, 2006, SCHOOL PSYCHOL REV, V35, P108
   Klin A., 2005, CLIN EVALUATION AUTI
   Mayes SD, 2004, CLIN NEUROPSYCHOL, V18, P559, DOI 10.1080/13854040490888530
   Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081
   Mayes SD, 2003, AUTISM, V7, P65, DOI 10.1177/1362361303007001006
   Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4
   Mayes SD, 2007, CHILD NEUROPSYCHOL, V13, P469, DOI 10.1080/09297040601112773
   McGonigle-Chalmers M, 2008, J AUTISM DEV DISORD, V38, P1382, DOI 10.1007/s10803-007-0396-y
   McGonigle-Chalmers M, 2013, J AUTISM DEV DISORD, V43, P80, DOI 10.1007/s10803-012-1545-5
   Miller L., 2014, J AUTISM DEV DISORDE
   Minshew NJ, 2005, J AUTISM DEV DISORD, V35, P45, DOI 10.1007/s10803-004-1030-x
   Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   Oliveras-Rentas RE, 2012, J AUTISM DEV DISORD, V42, P655, DOI 10.1007/s10803-011-1289-7
   Scheuffgen K, 2000, DEV PSYCHOPATHOL, V12, P83, DOI 10.1017/S095457940000105X
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Soulieres I., 2011, PLOS ONE, V6, P253
   Wechsler D., 2004, WECHSLER INTELLIGENC
   Wechsler D., 2003, WISC 4 TECHNICAL INT
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
NR 33
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1200
EP 1207
DI 10.1016/j.rasd.2014.06.007
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600020
ER

PT J
AU Dixon, MR
   Whiting, SW
   Rowsey, K
   Belisly, J
AF Dixon, Mark R.
   Whiting, Seth W.
   Rowsey, Kyle
   Belisly, Jordan
TI Assessing the relationship between intelligence and the PEAK relational
   training system
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE ABA therapy; Intelligence quotient; Language; Verbal behavior therapy
ID AUTISM SPECTRUM DISORDERS; BEHAVIORAL TREATMENT; CHILDREN; IQ;
   PREDICTORS
AB The Promoting the Emergence of Advanced Knowledge (PEAK) Relational Training System is an assessment and curriculum tool developed for basic and advanced skills using behavior analytic approaches. The current study evaluated the relationship between intelligence (as measured by IQ scores) and performance on the PEAK assessment with children with autism or other developmental and intellectual disabilities. Each child was administered the PEAK assessment from the Direct Training Module. Scores from this assessment were compared to IQ scores for all participants to assess the relationship between the two measures. Results indicated a strong, significant correlation between scores on standardized IQ tests and scores on the PEAK assessment (r= .759, p< .01). The results demonstrated strong convergent validity and indicate that the PEAK may be a useful assessment and curriculum guide for training language and learning skills to individuals with autism and other developmental disabilities. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Dixon, Mark R.; Whiting, Seth W.; Rowsey, Kyle; Belisly, Jordan] So Illinois Univ, Carbondale, IL 62901 USA.
RP Dixon, MR (reprint author), So Illinois Univ, Carbondale, IL 62901 USA.
EM mdixon@siu.edu
CR Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331
   Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
   Brody N, 1997, AM PSYCHOL, V52, P1046, DOI 10.1037/0003-066X.52.10.1046
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Dixon M. R, J DEV PHYS IN PRESS
   Dixon M. R., 2014, PEAK RELATIONAL TRAI
   Greer R Douglas, 2005, Anal Verbal Behav, V21, P99
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Hayward D. V., 2008, LANGUAGE PHONOLOGICA, P1
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Partington J. W., 2008, ASSESSMENT BASIC LAN
   Reichow B, 2009, J AUTISM DEV DISORD, V39, P23, DOI 10.1007/s10803-008-0596-0
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
   Sternberg RJ, 2001, MERRILL PALMER QUART, V47, P1, DOI 10.1353/mpq.2001.0005
   Sturmey P, 2002, CURR OPIN PSYCHIATR, V15, P489, DOI 10.1097/00001504-200209000-00005
   Sundberg M. L., 2008, VERBAL BEHAV MILESTO
   Wagner RK, 1997, AM PSYCHOL, V52, P1059, DOI 10.1037/0003-066X.52.10.1059
   YAMAMOTO J, 1988, J APPL BEHAV ANAL, V21, P57, DOI 10.1901/jaba.1988.21-57
NR 20
TC 4
Z9 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1208
EP 1213
DI 10.1016/j.rasd.2014.05.005
PG 6
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600021
ER

PT J
AU Tomchek, SD
   Huebner, RA
   Dunn, W
AF Tomchek, Scott D.
   Huebner, Ruth A.
   Dunn, Winnie
TI Patterns of sensory processing in children with an autism spectrum
   disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Sensory processing; Assessment
ID YOUNG-CHILDREN; ASPERGER SYNDROME; INFANTILE-AUTISM; MOTOR IMPAIRMENT;
   LEARNING-DISABILITIES; DEVELOPMENTAL DELAY; TYPICAL DEVELOPMENT;
   ADAPTIVE-BEHAVIOR; ABNORMALITIES; SYMPTOMS
AB The literature describing individuals with autism spectrum disorders (ASDs) commonly includes descriptions of differences in sensory processing. The purpose of this study was to describe patterns of sensory processing found in 400 children with an ASD. Exploratory factor analysis identified 6 parsimonious factors: low energy/weak, tactile and movement sensitivity, taste/smell sensitivity, auditory and visual sensitivity, sensory seeking/distractibility, and hypo-responsivity. These factors are consistent with other reports about differences in sensory processing. Findings provide insights about practice and future research. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Tomchek, Scott D.] Univ Louisville, Sch Med, Weisskopf Child Evaluat Ctr, Dept Pediat, Louisville, KY 40202 USA.
   [Huebner, Ruth A.] Eastern Kentucky Univ, Richmond, KY USA.
   [Tomchek, Scott D.; Dunn, Winnie] Univ Kansas, Med Ctr, Occupat Therapy Educ Program, Lawrence, KS 66045 USA.
RP Tomchek, SD (reprint author), Univ Louisville, Weisskopf Child Evaluat Ctr, Dept Pediat, 571 South Floyd St,Suite 100, Louisville, KY 40202 USA.
EM scott.tomchek@lousville.edu
CR Adrien J L, 1992, Acta Paedopsychiatr, V55, P71
   ADRIEN JL, 1987, J AUTISM DEV DISORD, V17, P407, DOI 10.1007/BF01487069
   ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   American Psychiatric Association, 2001, DIAGN STAT MAN MENT, V4th
   Ashburner J, 2008, AM J OCCUP THER, V62, P564
   Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
   Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Bar-Shalita T, 2009, PHYSIOL BEHAV, V98, P631, DOI 10.1016/j.physbeh.2009.09.020
   Ben-Sasson A, 2007, AM J OCCUP THER, V61, P584
   Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
   Bettison S., 1994, SPECIAL ED PERSPECTI, V3
   Bibby P, 2001, RES DEV DISABIL, V22, P425, DOI 10.1016/S0891-4222(01)00082-8
   Brown Ted, 2008, Phys Occup Ther Pediatr, V28, P253, DOI 10.1080/01942630802224983
   CESARONI L, 1991, J AUTISM DEV DISORD, V21, P303, DOI 10.1007/BF02207327
   DAHLGREN SO, 1989, EUR ARCH PSY CLIN N, V238, P169
   Dunn W, 1997, INFANT YOUNG CHILD, V9, P23
   Dunn W., 2006, SENSORY PROFILE SUPP
   Ermer J, 1998, AM J OCCUP THER, V52, P283
   Filipek PA, 2000, NEUROLOGY, V55, P468
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   GHAZIUDDIN M, 1992, J AUTISM DEV DISORD, V22, P651, DOI 10.1007/BF01046333
   Gillberg C, 1996, DEV MED CHILD NEUROL, V38, P191
   Goldstein H, 2000, J AUTISM DEV DISORD, V30, P423, DOI 10.1023/A:1005599406819
   Grandin T., 1995, THINKING PICTURES
   Grandin T., 1986, EMERGENCE LABELED AU
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
   Haas RH, 1996, J CHILD NEUROL, V11, P84
   Hilton C, 2007, RES AUTISM SPECT DIS, V1, P339, DOI 10.1016/j.rasd.2006.12.003
   Hughes C, 1996, J AUTISM DEV DISORD, V26, P99, DOI 10.1007/BF02276237
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Jones RSP, 2003, J INTELLECT DEV DIS, V28, P112, DOI 10.1080/1366825031000147058
   JONES V, 1985, J AUTISM DEV DISORD, V15, P37, DOI 10.1007/BF01837897
   Joosten AV, 2010, AUST OCCUP THER J, V57, P366, DOI 10.1111/j.1440-1630.2009.00835.x
   Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564
   Kientz MA, 1997, AM J OCCUP THER, V51, P530
   Kinnealey M, 2012, AM J OCCUP THER, V66, P511, DOI 10.5014/ajot.2012.004010
   KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y
   Leary MR, 1996, MENT RETARD, V34, P39
   Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
   Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
   LORD C, 1989, J AUTISM DEV DISORD, V19, P483, DOI 10.1007/BF02212853
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
   Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   Miller LJ, 2000, SENSORY INTEGRATION, V23, P1
   Miller U., 2001, UNDERSTANDING NATURE, P57
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   Minshew NJ, 2008, J AUTISM DEV DISORD, V38, P1485, DOI 10.1007/s10803-007-0528-4
   Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
   Nass R, 1997, DEV MED CHILD NEUROL, V39, P691
   National Research Council, 2001, ED CHILDR AUT
   O'Donnell S, 2012, AM J OCCUP THER, V66, P586, DOI 10.5014/ajot.2012.004168
   Ornitz E. M., 1989, AUTISM NATURE DIAGNO, P174
   ORNITZ EM, 1993, J AUTISM DEV DISORD, V23, P619, DOI 10.1007/BF01046105
   Provost Beth, 2007, Phys Occup Ther Pediatr, V27, P21, DOI 10.1300/J006v27n03_03
   Provost B, 2007, J AUTISM DEV DISORD, V37, P321, DOI 10.1007/s10803-006-0170-6
   Reynolds S., 2009, AM OCC THER ASS NAT
   Reynolds S, 2011, J AUTISM DEV DISORD, V41, P1496, DOI 10.1007/s10803-010-1173-x
   RIMLAND B, 1995, J AUTISM DEV DISORD, V25, P61, DOI 10.1007/BF02178168
   Ruble LA, 2007, J AUTISM DEV DISORD, V37, P1457, DOI 10.1007/s10803-006-0222-y
   Schoen S.A., 2009, FRONTIERS INTEGRATIV, V3, P1, DOI DOI 10.3389/NEURO.07.029.2009
   Staples KL, 2010, J AUTISM DEV DISORD, V40, P209, DOI 10.1007/s10803-009-0854-9
   Stevens J., 2002, APPL MULTIVARIATE ST
   Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Tomchek SD, 2007, AM J OCCUP THER, V61, P190
   Vicker B. A., 1993, P 1993 INT C AUT
   Volkmar Fred, 1999, Journal of the American Academy of Child and Adolescent Psychiatry, V38, p32S
   Watling RL, 2001, AM J OCCUP THER, V55, P416
   Wiggins LD, 2009, J AUTISM DEV DISORD, V39, P1087, DOI 10.1007/s10803-009-0711-x
   YeungCourchesne R, 1997, DEV PSYCHOPATHOL, V9, P389
NR 82
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1214
EP 1224
DI 10.1016/j.rasd.2014.06.006
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600022
ER

PT J
AU Stern, JA
   Gadgil, MS
   Blakeley-Smith, A
   Reaven, JA
   Hepburn, SL
AF Stern, Jessica A.
   Gadgil, Milind S.
   Blakeley-Smith, Audrey
   Reaven, Judy A.
   Hepburn, Susan L.
TI Psychometric properties of the SCARED in youth with autism spectrum
   disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Anxiety; Assessment; Validity; Factor analysis
ID CHILDRENS ANXIETY SCALE; TEST-RETEST RELIABILITY; EMOTIONAL DISORDERS;
   DSM-IV; PSYCHIATRIC-DISORDERS; DIAGNOSTIC INTERVIEW; CO-MORBIDITY;
   SCREEN; VALIDITY; ADOLESCENTS
AB Children with autism spectrum disorder (ASD) are at increased risk of developing co-occurring anxiety symptoms. However, the assessment of anxiety symptoms in this population is often challenging for researchers and clinicians. This study evaluated the psychometric properties of a questionnaire measure of child anxiety symptoms, the Screen for Child Anxiety Related Emotional Disorders (SCARED), in school-aged children and adolescents with high-functioning ASD. Children and parents recruited for an anxiety treatment study completed the SCARED parent and child versions prior to the start of treatment. Both versions demonstrated factor structures, internal reliability, and score distributions largely consistent with those from typically developing samples (Birmaher et al., 1999). The SCARED showed moderate convergent validity with a structured clinical interview and had good sensitivity and specificity. Differences were explored by child age, gender, and ethnicity. Together, these findings support the use of the SCARED as a valid assessment tool in an ASD population. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Stern, Jessica A.; Blakeley-Smith, Audrey; Reaven, Judy A.; Hepburn, Susan L.] Univ Colorado, Denver Sch Med, Dept Psychiat, Aurora, CO 80045 USA.
   [Gadgil, Milind S.] Kaiser Permanente Colorado Reg, Hidden Lake Mental Hlth, Arvada, CO 80003 USA.
RP Hepburn, SL (reprint author), Univ Colorado, Denver Sch Med, Dept Psychiat, 13121 E 17th Pl,Mailstop C-234, Aurora, CO 80045 USA.
EM susan.hepburn@ucdenver.edu
CR Achenbach T. M, 1980, CHILD BEHAV CHECKLIS
   Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Birmaher B, 1997, J AM ACAD CHILD PSY, V36, P545, DOI 10.1097/00004583-199704000-00018
   Blakeley-Smith A, 2012, RES AUTISM SPECT DIS, V6, P707, DOI 10.1016/j.rasd.2011.07.020
   Blakeley-Smith A., USE PARENT TEE UNPUB
   Bodden DHM, 2009, BEHAV RES THER, V47, P418, DOI 10.1016/j.brat.2009.01.015
   Brown TA, 2009, PSYCHOL ASSESSMENT, V21, P256, DOI 10.1037/a0016608
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Essau CA, 2002, J BEHAV THER EXP PSY, V33, P1, DOI 10.1016/S0005-7916(02)00005-8
   Fergusson DM, 2002, ARCH GEN PSYCHIAT, V59, P225, DOI 10.1001/archpsyc.59.3.225
   Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7
   Grant BF, 2005, PSYCHOL MED, V35, P1747, DOI 10.1017/S0033291705006069
   Hale WW, 2011, J CHILD PSYCHOL PSYC, V52, P80, DOI 10.1111/j.1469-7610.2010.02285.x
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kerns CM, 2012, CLIN PSYCHOL-SCI PR, V19, P323, DOI 10.1111/cpsp.12009
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Lecavalier L, 2006, AM J MENT RETARD, V111, P199, DOI 10.1352/0895-8017(2006)111[199:VOTADI]2.0.CO;2
   Lecavalier L, 2014, J AUTISM DEV DISORD, V44, P1128, DOI 10.1007/s10803-013-1974-9
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lyneham HJ, 2005, J AM ACAD CHILD PSY, V44, P274, DOI 10.1097/00004583-200503000-00012
   March JS, 1999, J ANXIETY DISORD, V13, P349, DOI 10.1016/S0887-6185(99)00009-2
   MESSER SC, 1994, J AM ACAD CHILD PSY, V33, P975, DOI 10.1097/00004583-199409000-00007
   Monga S, 2000, DEPRESS ANXIETY, V12, P85, DOI 10.1002/1520-6394(2000)12:2<85::AID-DA4>3.0.CO;2-2
   Muris P, 1998, J BEHAV THER EXP PSY, V29, P327, DOI 10.1016/S0005-7916(98)00023-8
   Muris P, 2006, BEHAV RES THER, V44, P883, DOI 10.1016/j.brat.2005.06.002
   Muris P, 2002, J AM ACAD CHILD PSY, V41, P1360, DOI 10.1097/01.CHI.0000024843.60748.08
   Pine DS, 1998, ARCH GEN PSYCHIAT, V55, P56, DOI 10.1001/archpsyc.55.1.56
   Reaven J., 2012, AUTISM RES TREATMENT, P1
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   Reynolds CR, 1985, REVISED CHILDRENS MA
   Silverman W. K., 1996, ANXIETY DISORDERS IN
   Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
   Silverman WK, 2005, J CLIN CHILD ADOLESC, V34, P380, DOI 10.1207/s15374424jccp3403_2
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Southam-Gerow MA, 2003, J ANXIETY DISORD, V17, P427, DOI 10.1016/S0887-6185(02)00223-2
   Spence SH, 2003, J ANXIETY DISORD, V17, P605, DOI 10.1016/S0887-6185(02)00236-0
   Spielberger CD, 1970, STATE TRAIT ANXIETY
   Storch EA, 2012, J CHILD ADOL PSYCHOP, V22, P292, DOI 10.1089/cap.2011.0114
   Su LY, 2008, J ANXIETY DISORD, V22, P612, DOI 10.1016/j.janxdis.2007.05.011
   van Steensel FJA, 2013, AUTISM, V17, P681, DOI 10.1177/1362361312455875
   Weitkamp K, 2010, CHILD ADOL PSYCH CL, V4, P1
   Weschler D., 2002, WESCHLER PRESCHOOL P
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Wittchen HU, 1999, PSYCHOL MED, V29, P309, DOI 10.1017/S0033291798008174
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
   Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
   Wren FJ, 2004, J AM ACAD CHILD PSY, V43, P1364, DOI 10.1097/01.chi.0000138350.60487.d3
NR 51
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1225
EP 1234
DI 10.1016/j.rasd.2014.06.008
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600023
ER

PT J
AU Tung, LC
   Huang, CY
   Tseng, MH
   Yen, HC
   Tsai, YP
   Lin, YC
   Chen, KL
AF Tung, Li-Chen
   Huang, Chien-Yu
   Tseng, Mei-Hui
   Yen, Hsui-Chen
   Tsai, Yu-Pei
   Lin, Yu-Ching
   Chen, Kuan-Lin
TI Correlates of health-related quality of life and the perception of its
   importance in caregivers of children with autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Health-related quality of life; Autism; Parenting stress; Behavior
   problems
ID CHILDHOOD AUTISM; PARENTING STRESS; RATING-SCALE; DISORDERS; BEHAVIOR;
   VERSION; MOTHERS; DISABILITY; VALIDITY; AGE
AB This study aims to investigate the correlates of health-related quality of life (HRQOL) and perceptions of the importance of each HRQOL domain in caregivers of children with autism. Eighty-two caregivers completed the World Health Organization Quality of Life and Parenting Stress Index Short Form to respectively measure the caregivers' HRQOL and parenting stress. The Childhood Autism Rating Scale and the Strength and Difficulties Questionnaire were used to respectively assess severity of autism and children's behavior problems. Results revealed that severity of autism, behavior problems, and parenting stress individually had low to moderate associations with HRQOL. However, all variables considered together, only parental distress (parent-related stress) significantly contributed to the four HRQOL domains. In addition, the physical domain was the most important HRQOL domain to caregivers, and environmental domain, the least. Knowledge of the correlates of HRQOL and the importance of each HRQOL domain could serve as guides for clinicians to improve the HRQOL of caregivers of children with autism by targeting parental distress and focusing on the HRQOL domains perceived as most important by caregivers. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Tung, Li-Chen; Yen, Hsui-Chen; Tsai, Yu-Pei] Chi Mei Med Ctr, Dept Phys Med & Rehabil, Tainan 710, Taiwan.
   [Tung, Li-Chen] Kaohsiung Med Univ, Sch Med, Kaohsiung 807, Taiwan.
   [Huang, Chien-Yu; Tseng, Mei-Hui] Natl Taiwan Univ, Coll Med, Sch Occupat Therapy, Taipei 100, Taiwan.
   [Lin, Yu-Ching] Natl Cheng Kung Univ Hosp, Tainan 704, Taiwan.
   [Chen, Kuan-Lin] Natl Cheng Kung Univ, Coll Med, Sch Occupat Therapy, Tainan 701, Taiwan.
RP Chen, KL (reprint author), Natl Cheng Kung Univ, Coll Med, Sch Occupat Therapy, 1 Univ Rd, Tainan 701, Taiwan.
EM klchen@mail.ncku.edu.tw
CR ABIDIN RR, 1992, J CLIN CHILD PSYCHOL, V21, P407, DOI 10.1207/s15374424jccp2104_12
   Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Andrews G, 1998, BRIT J PSYCHIAT, V173, P123, DOI 10.1192/bjp.173.2.123
   Beach SR, 2005, J AM GERIATR SOC, V53, P255, DOI 10.1111/j.1532-5415.2005.53111.x
   Bourke-Taylor H, 2010, AUST OCCUP THER J, V57, P127, DOI 10.1111/j.1440-1630.2009.00817.x
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   Deater-Deckard K. D., 2004, PARENTING STRESS
   Donohue PK, 2002, MENT RETARD DEV D R, V8, P293, DOI 10.1002/mrdd.10041
   Du Yasong, 2008, Child Adolesc Psychiatry Ment Health, V2, P8, DOI 10.1186/1753-2000-2-8
   EAVES RC, 1993, J ABNORM CHILD PSYCH, V21, P481, DOI 10.1007/BF00916315
   Huang CY, 2014, J AUTISM DEV DISORD, V44, P1383, DOI 10.1007/s10803-013-2000-y
   Khanna R, 2011, J AUTISM DEV DISORD, V41, P1214, DOI 10.1007/s10803-010-1140-6
   Kheir N, 2012, AUTISM, V16, P293, DOI 10.1177/1362361311433648
   Lee GK, 2009, FOCUS AUTISM DEV DIS, V24, P227, DOI 10.1177/1088357609347371
   Mond JM, 2005, QUAL LIFE RES, V14, P171, DOI 10.1007/s11136-004-2657-y
   Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Shu BC, 2009, AUTISM, V13, P81, DOI 10.1177/1362361307098517
   Skevington SM, 2004, QUAL LIFE RES, V13, P299, DOI 10.1023/B:QURE.0000018486.91360.00
   SPITZER RL, 1995, JAMA-J AM MED ASSOC, V274, P1511, DOI 10.1001/jama.274.19.1511
   TAYLOR R, 1990, J DIAGN MED SONOG, V6, P35, DOI 10.1177/875647939000600106
   Harper A, 1998, PSYCHOL MED, V28, P551
   Tobing LE, 2002, RES DEV DISABIL, V23, P211, DOI 10.1016/S0891-4222(02)00099-9
   World Health Organisation, 1992, ICD 10 INT STAT CLAS
   Yamada A, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-119
   Yao G, 2002, J FORMOS MED ASSOC, V101, P342
   Yeh CH, 2001, ACTA PAEDIATR, V90, P1470
NR 28
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1235
EP 1242
DI 10.1016/j.rasd.2014.06.010
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600024
ER

PT J
AU Hill, TL
   Varela, RE
   Kamps, JL
   Niditch, LA
AF Hill, Trenesha L.
   Varela, R. Enrique
   Kamps, Jodi L.
   Niditch, Laura A.
TI Local processing and social skills in children with Autism Spectrum
   Disorders: The role of anxiety and cognitive functioning
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Local processing; Anxiety; Social skills;
   Cognitive functioning
ID PERVASIVE DEVELOPMENTAL DISORDERS; WEAK CENTRAL COHERENCE; DIAGNOSTIC
   INTERVIEW; INDIVIDUALS; ATTENTION; FACES; ASSOCIATION; PERFORMANCE;
   PRECEDENCE; INVERSION
AB The present study examined the relations between anxiety, cognitive functioning, local processing, and social skills in a group of 102 children diagnosed with an Autism Spectrum Disorder. The results indicated that children diagnosed with Asperger's Disorder had significantly higher cognitive functioning and enhanced local processing (i.e., Block Design scores) compared to those diagnosed with Autistic Disorder or PDD-NOS. Regression analyses results showed that anxiety and cognitive functioning moderated the association between local processing and social skills. For children with low cognitive functioning and high anxiety, greater local processing was associated with poorer social skills than those with high cognitive functioning, high anxiety, and greater local processing. For children with high cognitive functioning and high anxiety, enhanced local processing was associated with better social skills than those with high cognitive functioning and reduced local processing. Implications of these findings are discussed. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Hill, Trenesha L.; Varela, R. Enrique; Niditch, Laura A.] Tulane Univ, Dept Psychol, New Orleans, LA 70118 USA.
   [Kamps, Jodi L.] Childrens Hosp, New Orleans, LA 70118 USA.
RP Varela, RE (reprint author), Tulane Univ, Dept Psychol, 2007 Percival Stern Hall,6400 Freret St, New Orleans, LA 70118 USA.
EM thill@tulane.edu; evarela@tulane.edu; jkamps@chnola.org;
   lniditch@tulane.edu
CR American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
   BARTLETT JC, 1993, COGNITIVE PSYCHOL, V25, P281, DOI 10.1006/cogp.1993.1007
   Basso M R, 1996, J Int Neuropsychol Soc, V2, P249
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Burnette CP, 2005, J AUTISM DEV DISORD, V35, P63, DOI 10.1007/s10803-004-1035-5
   CAPPS L, 1995, DEV PSYCHOPATHOL, V7, P137
   Centers for Disease Control and Prevention, 2012, MMWR-MORBID MORTAL W, P61
   Derryberry D, 1998, PERS INDIV DIFFER, V25, P745, DOI 10.1016/S0191-8869(98)00117-2
   DIAMOND R, 1986, J EXP PSYCHOL GEN, V115, P107, DOI 10.1037/0096-3445.115.2.107
   Estes AM, 2007, AM J MENT RETARD, V112, P439, DOI 10.1352/0895-8017(2007)112[439:LOIFPP]2.0.CO;2
   FARAH MJ, 1995, J EXP PSYCHOL HUMAN, V21, P628, DOI 10.1037//0096-1523.21.3.628
   Fredrickson BL, 2005, COGNITION EMOTION, V19, P313, DOI 10.1080/02699930441000238
   Frith U., 1989, AUTISM EXPLAINING TH
   Hanoch Y, 2004, THEOR PSYCHOL, V14, P427, DOI 10.1177/0959354304044918
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Kohs S. C., 1923, THE TEST MATERIAL
   Lecavalier L, 2006, AM J MENT RETARD, V111, P199, DOI 10.1352/0895-8017(2006)111[199:VOTADI]2.0.CO;2
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
   Morgan B, 2003, DEV PSYCHOL, V39, P646, DOI 10.1037/0012-1649.39.4.646
   NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
   Niditch LA, 2012, J CLIN CHILD ADOLESC, V41, P127, DOI 10.1080/15374416.2012.651994
   Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
   Reynolds C. R., 2004, BEHAVIOR ASSESSMENT
   RHODES G, 1988, PERCEPTION, V17, P43, DOI 10.1068/p170043
   Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748
   Schopler E., 1992, MANIFESTATIONS OF SO, P129
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Srinivasan N, 2010, COGNITION EMOTION, V24, P1062, DOI 10.1080/02699930903101103
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Wechsler D., 2002, WECHSLER PRESCHOOL A
NR 33
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2014
VL 8
IS 9
BP 1243
EP 1251
DI 10.1016/j.rasd.2014.06.005
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AN6GS
UT WOS:000340693600025
ER

PT J
AU Rosqvist, HB
AF Rosqvist, Hanna Bertilsdotter
TI Becoming an 'Autistic Couple': Narratives of Sexuality and Couplehood
   Within the Swedish Autistic Self-advocacy Movement
SO SEXUALITY AND DISABILITY
LA English
DT Article
DE Couple; Autism; Autistic sexuality; Neurotypical sexuality;
   Self-advocacy; Sweden
ID PARENTAL PERSPECTIVE; ADOLESCENTS; ADULTS; ATTITUDES; KNOWLEDGE;
   DISORDER
AB Research on sexuality and autism is dominated by a sexually deficit view of autism. According to this view, people with autism are considered different from neurotypicals and in need of sexual education that is specially adapted to the social impairments of people with autism. Perspectives on sexuality, couplehood, and autism are gradually changing, and this is partly because of alternative views on autism expressed and advocated within autistic self-advocacy movements. The present paper explores discourses within the Swedish autistic self-advocacy movement of an 'autistic' sexuality and couplehood (sexuality and couplehood on people with autism's own terms). The analysis is based on articles in a Swedish magazine, Empowerment, published between 2002 and 2009 that was produced by and aimed at adults with autism.
C1 Umea Univ, Dept Social Work, S-90187 Umea, Sweden.
RP Rosqvist, HB (reprint author), Umea Univ, Dept Social Work, S-90187 Umea, Sweden.
EM hanna.bertilsdotter.rosqvist@umu.se
CR Areschoug J., 2005, J DISABIL RES, V7, P155
   Armstrong T., 2010, NEURODIVERSITY DISCO
   Ballan MS, 2012, J AUTISM DEV DISORD, V42, P676, DOI 10.1007/s10803-011-1293-y
   Bray-Garretson H., 2004, SEXUAL ADDICTION COM, V11, P265, DOI DOI 10.1080/10720160490900614
   Davidson J, 2010, SOC SCI MED, V70, P305, DOI 10.1016/j.socscimed.2009.10.017
   Edley Nigel, 2001, DISCOURSE DATA GUIDE
   Garland-Thomson R., 1997, EXTRAORDINARY BODIES
   Hardaway E., 2009, TEACHING EXCEPTIONAL, V42, P50
   Hellemans H, 2010, SEX DISABIL, V28, P93, DOI 10.1007/s11195-009-9145-9
   Jones RL, 2002, NARRAT INQ, V12, P121, DOI 10.1075/ni.12.1.18jon
   Koller R, 2000, SEX DISABIL, V18, P125, DOI 10.1023/A:1005567030442
   Konstantareas MM, 1997, J AUTISM DEV DISORD, V27, P397, DOI 10.1023/A:1025805405188
   Laqueur Thomas, 2003, SOLITARY SEX CULTURA
   Mehzabin P, 2011, RES AUTISM SPECT DIS, V5, P614, DOI 10.1016/j.rasd.2010.07.006
   Oliver M., 1990, POLITICS DISABLEMENT
   Ortega F, 2009, BIOSOCIETIES, V4, P425, DOI 10.1017/S1745855209990287
   OUSLEY OY, 1991, J AUTISM DEV DISORD, V21, P471, DOI 10.1007/BF02206871
   RUBLE LA, 1993, ARCH SEX BEHAV, V22, P229, DOI 10.1007/BF01541768
   Stokes M, 2007, J AUTISM DEV DISORD, V37, P1969, DOI 10.1007/s10803-006-0344-2
   Stokes MA, 2005, AUTISM, V9, P266, DOI 10.1177/1362361305053258
   Tissot C, 2009, AUTISM, V13, P551, DOI 10.1177/1362361309338183
   VanBourgondien ME, 1997, J AUTISM DEV DISORD, V27, P113, DOI 10.1023/A:1025883622452
   Ward M. J., 1999, FOCUS AUTISM OTHER D, V14, P133, DOI 10.1177/108835769901400302
NR 23
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0146-1044
EI 1573-6717
J9 SEX DISABIL
JI Sex. Disabil.
PD SEP
PY 2014
VL 32
IS 3
BP 351
EP 363
DI 10.1007/s11195-013-9336-2
PG 13
WC Rehabilitation
SC Rehabilitation
GA AN4PN
UT WOS:000340570200009
ER

PT J
AU Byers, ES
   Nichols, S
AF Byers, E. Sandra
   Nichols, Shana
TI Sexual Satisfaction of High-Functioning Adults with Autism Spectrum
   Disorder
SO SEXUALITY AND DISABILITY
LA English
DT Article
DE Sexual satisfaction; Autism spectrum disorder; Sexuality; Asperger
   syndrome; Canada; United States
ID INTERPERSONAL EXCHANGE MODEL; RESPONSE RATES; HELP-SEEKING; QUOTIENT AQ;
   ADOLESCENTS; SAMPLE; MEN; VALIDATION; VALIDITY; INDIVIDUALS
AB This study examined the validity of the Interpersonal Exchange Model of Sexual Satisfaction (IEMSS) as a framework for understanding the sexual satisfaction of 205 adults (77 men and 128 women) with high-functioning autism spectrum disorder (HF-ASD) who were in a romantic relationship of at least 3 months duration. Participants completed an online survey that included a background questionnaire, the IEMSS Questionnaire, and a measure of autism symptoms. The results provide support for the validity of the IEMSS in that all the IEMSS components (relationship satisfaction, balance of sexual rewards and costs, balance of relative sexual rewards and costs, equality of rewards, equality of costs) were significantly associated with sexual satisfaction. Relationship satisfaction and the balance of rewards and costs added over and above the other components. The model was not moderated by gender, relationship duration or extent of autism symptoms. However, participants with more autism symptoms related to social functioning reported lower sexual satisfaction as well as lower scores on all of the IEMSS components. There were few gender differences. These results are discussed in terms of the impact of HF-ASD on adults' experiences of their sexual satisfaction with their partner.
C1 [Byers, E. Sandra] Univ New Brunswick, Dept Psychol, Fredericton, NB E3B 5A3, Canada.
   [Nichols, Shana] ASPIRE Ctr Learning & Dev, Melville, NY USA.
RP Byers, ES (reprint author), Univ New Brunswick, Dept Psychol, POB 4400, Fredericton, NB E3B 5A3, Canada.
EM byers@unb.ca
CR Addis ME, 2003, AM PSYCHOL, V58, P5, DOI 10.1037/0003-066X.58.1.5
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Armstrong K, 2013, J AUTISM DEV DISORD, V43, P2228, DOI 10.1007/s10803-013-1769-z
   Barnhill G. P., 2007, FOCUS AUTISM OTHER D, V22, P116, DOI DOI 10.1177/10883576070220020301
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Byers E. S., 2009, J SEX RES, V46, P1
   Byers E. S., 1996, J PSYCHOL HUMAN SEXU, V8, P7, DOI [10.1300/1056008601_02, DOI 10.1300/J056V08N01_02]
   Byers ES, 2004, HANDBOOK OF SEXUALITY IN CLOSE RELATIONSHIPS, P203
   Byers ES, 2013, AUTISM, V17, P418, DOI 10.1177/1362361311431950
   Byers ES, 2005, J SEX RES, V42, P113
   Byers ES, 1998, J SOC PERS RELAT, V15, P257, DOI 10.1177/0265407598152008
   Byers ES, 2006, J SEX MARITAL THER, V32, P53, DOI 10.1080/00926230500232917
   Byers ES, 2013, J AUTISM DEV DISORD, V43, P2617, DOI 10.1007/s10803-013-1813-z
   Christopher FS, 2000, J MARRIAGE FAM, V62, P999, DOI 10.1111/j.1741-3737.2000.00999.x
   Cohen JN, 2008, INT J SEX HEALTH, V20, P162, DOI 10.1080/19317610802240105
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Gilmour L, 2012, RES AUTISM SPECT DIS, V6, P313, DOI 10.1016/j.rasd.2011.06.003
   Hellemans H, 2007, J AUTISM DEV DISORD, V37, P260, DOI 10.1007/s10803-006-0159-1
   Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
   Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
   KARNEY BR, 1995, PSYCHOL BULL, V118, P3, DOI 10.1037/0033-2909.118.1.3
   King R., 2012, ASPERGER SYNDROME AD
   Koller R, 2000, SEX DISABIL, V18, P125, DOI 10.1023/A:1005567030442
   Konstantareas MM, 1997, J AUTISM DEV DISORD, V27, P397, DOI 10.1023/A:1025805405188
   LaFrance B. H., 2010, SO COMMUNICATION J, V75, P195, DOI DOI 10.1080/10417940902787939
   Laumann EO, 2006, ARCH SEX BEHAV, V35, P145, DOI 10.1007/s10508-005-9005-3
   Lawrance K., 1992, CANADIAN J HUMAN SEX, V1, P123
   Lawrance K., 2011, HDB SEXUALITY RELATE, P525
   Lawrance KA, 1995, PERS RELATIONSHIP, V2, P267, DOI 10.1111/j.1475-6811.1995.tb00092.x
   Lepage JF, 2009, CAN J BEHAV SCI, V41, P272, DOI 10.1037/a0016248
   MacNeil S, 2005, J SOC PERS RELAT, V22, P169, DOI 10.1177/0265407505050942
   Mehzabin P, 2011, RES AUTISM SPECT DIS, V5, P614, DOI 10.1016/j.rasd.2010.07.006
   Miller SA, 2004, J SEX RES, V41, P301
   Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
   Pollmann MMH, 2010, J AUTISM DEV DISORD, V40, P470, DOI 10.1007/s10803-009-0888-z
   Rehman U. S., 2013, ESSENTIAL HDB WOMENS, V1, P25
   Renaud C, 1997, J SEX RES, V34, P399
   Renty J, 2007, J AUTISM DEV DISORD, V37, P1247, DOI 10.1007/s10803-006-0268-x
   Santor DA, 2007, J AM ACAD CHILD PSY, V46, P50, DOI 10.1097/01.chi.0000242247.45915.ee
   Sax LJ, 2003, RES HIGH EDUC, V44, P409, DOI 10.1023/A:1024232915870
   Sonie S, 2013, J AUTISM DEV DISORD, V43, P1178, DOI 10.1007/s10803-012-1663-0
   Stokes MA, 2005, AUTISM, V9, P266, DOI 10.1177/1362361305053258
   STRASSBERG DS, 1995, ARCH SEX BEHAV, V24, P369, DOI 10.1007/BF01541853
   Tabachnik B. G., 2007, USING MULTIVARIATE S, V5th
   Tarnai B, 2008, SEX DISABIL, V26, P29, DOI 10.1007/s11195-007-9067-3
   Thibaut JW, 1959, SOCIAL PSYCHOL GROUP
   Tolman D., 2013, APA HDB SEXUALITY PS
   Weiser EB, 2000, CYBERPSYCHOL BEHAV, V3, P167, DOI 10.1089/109493100316012
   Henault I, 2005, ASPERGER'S SYNDROME: INTERVENING IN SCHOOLS, CLINICS AND COMMUNITIES, P243
   WIEDERMAN MW, 1994, ARCH SEX BEHAV, V23, P203, DOI 10.1007/BF01542099
   Williamson G. M., 2004, J PSYCHOL HUMAN SEXU, V16, P17, DOI DOI 10.1300/J056V16N04_
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
   Yucel D, 2010, SOC SCI RES, V39, P725, DOI 10.1016/j.ssresearch.2009.09.002
NR 53
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0146-1044
EI 1573-6717
J9 SEX DISABIL
JI Sex. Disabil.
PD SEP
PY 2014
VL 32
IS 3
BP 365
EP 382
DI 10.1007/s11195-014-9351-y
PG 18
WC Rehabilitation
SC Rehabilitation
GA AN4PN
UT WOS:000340570200010
ER

PT J
AU Daley, TC
   Weisner, T
   Singhal, N
AF Daley, Tamara C.
   Weisner, Thomas
   Singhal, Nidhi
TI Adults with autism in India: A mixed-method approach to make meaning of
   daily routines
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE India; Autism Spectrum Disorders; Disability; Daily routine; Ecocultural
ID PARENTING STRESS; SPECTRUM DISORDERS; URBAN INDIA; CHILDREN;
   PERSPECTIVES; DISABILITY; FAMILIES; LIFE
AB Although individuals with Autism Spectrum Disorder (ASD) have been diagnosed in India for over fifty years, virtually nothing is known about the social circumstances of adults, their daily lives, and their families. Where are adults with autism? How do they spend their time? Who are they with, and what are they doing all day? A mixed-method approach was used to obtain information on daily routines of 54 adults with ASD living in New Delhi, India, and about parent levels of stress associated with these routines during a study collected from January through June, 2013. Whether or not they attended a structured setting during the day (59% did so), adults engaged in some 20 activities both inside and outside their home. Contrary to our expectations, most adults were not "hidden" and were out in public at least on occasion. Higher functioning adults were more likely to attend a structured setting, but parents described challenging behaviors, both adult and parent preference, and lack of options as reasons that adults stayed home. The amount of time adults spent outside their home was not associated with parent reported stress, but stress was significantly higher for mothers who were employed. Most families described adaptation to caring for their adult children. A partnership with an Indian nongovernmental organization provided mechanisms to amplify our research findings, making them meaningful to our participants and others. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Daley, Tamara C.] Westat Corp, Durham, NC 27703 USA.
   [Weisner, Thomas] Univ Calif Los Angeles, Dept Psychiat, Ctr Culture & Hlth, NPI Semel Inst Neurosci, Los Angeles, CA 90024 USA.
   [Singhal, Nidhi] Act Autism, New Delhi 110025, India.
RP Daley, TC (reprint author), Westat Corp, 1009 Slater Rd, Durham, NC 27703 USA.
EM TamaraDaley@westat.com
FU Foundation for Psychocultural Research [59892]; Robert Lemelson,
   President (FPR) - Culture, Brain, Development and Mental Health (CBDMH);
   Action For Autism, New Delhi; FPR
FX This project is funded through a grant from the Foundation for
   Psychocultural Research (Grant #59892), Robert Lemelson, President (FPR)
   - Culture, Brain, Development and Mental Health (CBDMH) (Tom Weisner,
   PI; Tamara Daley, Co-PI) and in partnership with Action For Autism, New
   Delhi (Nidhi Singhal and Merry Barua). FPR-UCLA CBDMH is one of the
   interdisciplinary programs initiated and funded by the FPR. The RAFIN
   Adult study was managed by Deepali Taneja, with key assistance from
   Sachita Suryanarayan. Additional team members in India were Tanvi Behl,
   Rubina Pradhan, and Simi Sunny. Rachel Brezis also contributed to the
   project while completing a postdoctorate at UCLA, supported by the FPR.
CR ABHYANKAR R R, 1981, Journal of Postgraduate Medicine (Bombay), V27, P44
   Abidin RR, 1995, PARENTING STRESS IND
   Albin R. W., 1996, POSITIVE BEHAV SUPPO, P81
   Arora M, 2011, SOUTH MED J, V104, P264, DOI 10.1097/SMJ.0b013e31820c015d
   Bannerjee G., 1975, INDIAN J PSYCHIAT, V17, P144
   Barua M., 2007, J RELIG DISABILITY H, V11, P29, DOI DOI 10.1300/J095V11N02_05
   Ben-Sasson A, 2013, J CHILD PSYCHOL PSYC, V54, P846, DOI 10.1111/jcpp.12035
   Bernheimer LP, 1995, TOP EARLY CHILD SPEC, V15, P415
   Bornstein MH, 2002, HUM DEV, V45, P257, DOI 10.1159/000064986
   Chaudhari D., 2008, DELHI PSYCHIAT, V11, P238
   Constantino J.N., 2012, W PSYCHOL SERVICES
   Daley T.C., 2013, J AUTISM DEV DISORD, P1
   Daley T.C., 2012, 11 ANN M INT M AUT R
   Daley TC, 2004, SOC SCI MED, V58, P1323, DOI 10.1016/S0277-9536(03)00330-7
   DeGrace BW, 2004, AM J OCCUP THER, V58, P543
   Duggal HS, 2001, AUST NZ J PSYCHIAT, V35, P390
   Duggal H S, 2001, Indian J Psychiatry, V43, P267
   Eriksson JM, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-49
   Gallimore R, 1999, LEA SPEC EDUC DISAB, P55
   Girimaji SC, 2010, CURR OPIN PSYCHIATR, V23, P441, DOI 10.1097/YCO.0b013e32833ad95c
   Glidden L.M., 2009, FAMILIES INT REV RES, V37
   Harkness S, 2011, J FAM PSYCHOL, V25, P799, DOI 10.1037/a0026204
   John A, 2012, J APPL RES INTELLECT, V25, P372, DOI 10.1111/j.1468-3148.2011.00672.x
   Krauss MW, 2005, J INTELL DISABIL RES, V49, P111, DOI 10.1111/j.1365-2788.2004.00599.x
   Lord C., 2012, W PSYCHOL SERVICES
   Mactavish JB, 2004, J INTELL DISABIL RES, V48, P123, DOI 10.1111/j.1365-2788.2004.00502.x
   Manohari S.M., 2013, J INDIAN ASS CHILD A, V9, P5
   Marshall P, 2007, ETHICAL CHALLENGES S
   Newschaffer CJ, 2005, PEDIATRICS, V115, pE277, DOI 10.1542/peds.2004-1958
   Pilling S., 2012, BMJ-BRIT MED J, V344
   Priestley M., 2001, DISABILITY LIFE COUR
   Seltzer M.M., 2000, INT REV RES MENT RET, V23, P267
   Sharma A., 2013, AUTISM OPEN ACCESS, V3, P113
   Sparrow S.S., 2005, SURV INTERVIEW FORM
   Super C.M., 1997, HDB CROSS CULTURAL P
   Watson SL, 2013, J INTELLECT DEV DIS, V38, P95, DOI 10.3109/13668250.2013.788136
   Weisner T., 2009, PURSUITS HAPPINESS W
   Weisner TS, 2005, INT CULT PSYCHOL, P41, DOI 10.1007/0-387-27550-9_3
   Weisner TS, 2002, HUM DEV, V45, P275, DOI 10.1159/000064989
   Wiles J, 2003, SOC SCI MED, V57, P1307, DOI 10.1016/S0277-9536(02)00508-7
   Zaidman-Zait A, 2010, J CHILD PSYCHOL PSYC, V51, P1269, DOI 10.1111/j.1469-7610.2010.02266.x
NR 41
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD SEP
PY 2014
VL 116
BP 142
EP 149
DI 10.1016/j.socscimed.2014.06.052
PG 8
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA AN6HN
UT WOS:000340695700017
PM 24998867
ER

PT J
AU Delgado, MS
   Camprubi, C
   Tumer, Z
   Martinez, F
   Mila, M
   Monk, D
AF Delgado, Marta Sanchez
   Camprubi, Cristina
   Tuemer, Zeynep
   Martinez, Francisco
   Mila, Montserrat
   Monk, David
TI Screening Individuals with Intellectual Disability, Autism and
   Tourette's Syndrome for KCNK9 Mutations and Aberrant DNA Methylation
   within the 8q24 Imprinted Cluster
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE Imprinting; methylation; KCNK9; autism spectrum disorder; intellectual
   disability
ID MENTAL-RETARDATION; GENE; EXPRESSION; TRAPPC9; UBE3A; IDENTIFICATION;
   HETEROGENEITY; DEFICIENCY; TRANSCRIPT; DISORDERS
AB The phenotype overlap between autism spectrum disorders (ASD) & intellectual disabilities (ID) is mirrored at the genetic level, with common genes being reported mutated in variety of developmental disabilities. However despite widespread genetic screening for mutations, in approximately 40-60% of childhood developmental disorders the genetic cause remains unknown. Several genome-wide linkage screens in ASD have identified a locus mapping to distal 8q. We have recently identified a novel brain-specific imprinted cluster at this location, which contains the reciprocally expressed maternal KCNK9 and paternally expressed non-coding PEG13 transcripts, the latter located within an intron of TRAPPC9. Interestingly, mutations of KCNK9 and TRAPPC9 have been reported in Birk-Barel mental retardation and non-syndromic familial forms of ID, respectively. Here, we report a genetic screen for KCNK9 coding mutations and potential epigenetic aberrations that could result in deregulated imprinting in a cohort of 120 ID, 86 ASD and 86 Tourette syndrome patients. Fifteen of the ID patients had clinical characteristics overlapping with Birk-Barel syndrome. Sequencing of the two coding exons of KCNK9 failed to identify pathologic mutations, with only one variant, rs2615374, being present with allele frequencies similar to those described in dbSNP database. DNA methylation profiling of the KCNK9 and TRAPPC9 promoters, the maternally methylated PEG13 DMR and a long-range enhancer region were normal in all patients. Our findings suggest that mutations of KCNK9 or epigenetic disturbances within the PEG13 imprinted cluster do not significantly contribute to the cause of the developmental disabilities tested in this study. (C) 2014 Wiley Periodicals, Inc.
C1 [Delgado, Marta Sanchez; Camprubi, Cristina; Monk, David] Bellvitge Inst Biomed Res IDIBELL, Imprinting & Canc Grp, Canc Epigenet & Biol Program PEBC, Barcelona 08907, Spain.
   [Tuemer, Zeynep] Rigshosp, Copenhagen Univ Hosp, Kennedy Ctr, Appl Human Mol Genet, Glostrup, Denmark.
   [Martinez, Francisco] Hosp Univ La Fe, Unitat Genet, Valencia, Spain.
   [Mila, Montserrat] CIBERER, Barcelona, Spain.
RP Monk, D (reprint author), Unidad Genet Med Sistemas Genom SL, Valencia 46980, Spain.
EM dmonk@idibell.cat
RI Martinez, Francisco/A-2543-2009
OI Martinez, Francisco/0000-0002-0589-2584
FU Spanish Ministerio de Educacion y Ciencia [BFU2011-27658]; Fundacio La
   Marato de TV3 [101130]; Lundbeck Foundation [R24-A2419]
FX Grant sponsor: Spanish Ministerio de Educacion y Ciencia (grant number
   BFU2011-27658 to DM) and the Fundacio La Marato de TV3 (101130 to DM)
   and Lundbeck Foundation (R24-A2419 to ZT).
CR Abou Jamra R, 2011, EUR J HUM GENET, V19, P1161, DOI 10.1038/ejhg.2011.98
   Barel O, 2008, AM J HUM GENET, V83, P193, DOI 10.1016/j.ajhg.2008.07.010
   Bartolomei MS, 2009, GENE DEV, V23, P2124, DOI 10.1101/gad.1841409
   Benlian P, 1996, AM J HUM GENET, V59, P431
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Brickley SG, 2007, J NEUROSCI, V27, P9329, DOI 10.1523/JNEUROSCI.1427-07.2007
   Buiting K, 2010, AM J MED GENET C, V154C, P365, DOI 10.1002/ajmg.c.30273
   Cohen D, 2002, AM J PSYCHIAT, V159, P148, DOI 10.1176/appi.ajp.159.1.148-a
   Court F, 2014, EPIGENET CHROMATIN, V7, DOI 10.1186/1756-8935-7-5
   Fradin D, 2010, PLOS ONE
   Hamdan FF, 2009, ANN NEUROL, V65, P748, DOI 10.1002/ana.21625
   Hamdan FF, 2011, BIOL PSYCHIAT, V69, P898, DOI 10.1016/j.biopsych.2010.11.015
   Houston I, 2013, NEUROPSYCHOPHARMACOL, V38, P183, DOI 10.1038/npp.2012.78
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kakar N, 2012, EUR J MED GENET, V55, P727, DOI 10.1016/j.ejmg.2012.08.010
   Khan MA, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-56
   Linden AM, 2007, J PHARMACOL EXP THER, V323, P924, DOI 10.1124/jpet.107.129544
   Madrigal I, 2011, EUR J HUM GENET, V19, P921, DOI 10.1038/ejhg.2011.41
   Marangi G, 2012, EUR J HUM GENET, V21, P229
   Meng LY, 2012, HUM MOL GENET, V21, P3001, DOI 10.1093/hmg/dds130
   Mir A, 2009, AM J HUM GENET, V85, P909, DOI 10.1016/j.ajhg.2009.11.009
   Mochida GH, 2009, AM J HUM GENET, V85, P897, DOI 10.1016/j.ajhg.2009.10.027
   Peters SU, 2013, AUTISM RES, V6, P42, DOI 10.1002/aur.1262
   Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
   Ruf N, 2007, HUM MOL GENET, V16, P2591, DOI 10.1093/hmg/ddm216
   Runte M, 2001, HUM MOL GENET, V10, P2687, DOI 10.1093/hmg/10.23.2687
   Samaco RC, 2005, HUM MOL GENET, V14, P483, DOI 10.1093/hmg/ddi045
   Smeets EE, 2012, MOL SYNDROMOL, V2, P113
   Tejada MI, 2006, CLIN GENET, V70, P140, DOI 10.1111/j.1399-0004.2006.00647.x
   Tomizawa S, 2011, DEVELOPMENT, V138, P811, DOI 10.1242/dev.061416
   Trikalinos TA, 2006, MOL PSYCHIATR, V11, P29, DOI 10.1038/sj.mp.4001750
   van Bokhoven H, 2011, ANNU REV GENET, V45, P81, DOI 10.1146/annurev-genet-110410-132512
   VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
   Ylisaukko-oja T, 2006, ANN NEUROL, V59, P145, DOI 10.1002/ana.20722
   Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 35
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP
PY 2014
VL 165
IS 6
BP 472
EP 478
DI 10.1002/ajmg.b.32250
PG 7
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA AN3OF
UT WOS:000340497100003
ER

PT J
AU Rowe, G
   Nevin, H
AF Rowe, Gareth
   Nevin, Helen
TI Bringing 'patient voice' into psychological formulations of in-patients
   with intellectual disabilities, autism spectrum disorder and severe
   challenging behaviours: report of a service improvement pilot
SO BRITISH JOURNAL OF LEARNING DISABILITIES
LA English
DT Article
DE Autism; challenging behaviour; communication; learning (intellectual)
   disabilities; nursing; profound and complex learning disabilities
ID MENTAL-HEALTH; INDIVIDUALS; PEOPLE; CHOICE; QUESTION; CHILDREN; QUALITY;
   ADULTS; LIFE; CARE
AB This is a report of a service improvement pilot project undertaken at an inpatient autism service for adults with intellectual disabilities and severe challenging behaviours. Within the service, a key facet of the care pathway was the use of a biopsychosocial case formulation. Formulation meetings were led by psychology and involved a full multidisciplinary team and external representation. However, routine invitation of patients was not appropriate due to anxiety and complex communication difficulties. Therefore, the service was looking for alternative ways to incorporate the voices of patients into formulation. This report presents the case studies of four individual patients who were chosen because together they were indicative of the patient profile across the service. The study has demonstrated that it is possible to include patients' voices in their psychological formulation. For those with mild intellectual disabilities and mild autism spectrum disorder, this has been simple and extremely fruitful. For those with severe intellectual disability and severe autism spectrum disorder this has been more resource intensive and the results have been more tentative. Despite this, it has been demonstrated that it is possible to include the voices of all patients to some extent.
C1 [Rowe, Gareth; Nevin, Helen] Northumberland Tyne & Wear NHS Fdn Trust, Northgate Hosp, Morpeth NE61 3BP, England.
RP Rowe, G (reprint author), Northumberland Tyne & Wear NHS Fdn Trust, Northgate Hosp, Morpeth NE61 3BP, England.
EM helen.nevin@ntw.nhs.uk
CR Agnew SE, 2006, LEGAL CRIMINOL PSYCH, V11, P35, DOI 10.1348/135532505X68494
   Bogdashina O, 2003, SENSORY PERCEPTUAL I
   British Psychological Society, 2007, NEW WAYS WORK APPL P
   Caldwell P., 2007, ISOLATION INTIMACY M
   Caldwell P., 1998, PERSON PERSON ESTABL
   CAMERON L, 2002, BRIT J LEARN DISABIL, V30, P105, DOI DOI 10.1046/J.1468-3156.2002.00165.X
   Care Quality Commission, 2011, REV COMPL CASTL CAR
   Carr E. G., 1999, FUNCTIONAL ANAL PROB, P9
   Chiang HM, 2008, J AUTISM DEV DISORD, V38, P693, DOI 10.1007/s10803-007-0436-7
   Clements J., 2005, PEOPLE AUTISM BEHAV
   Cooper Phyllis G, 2004, Nurs Forum, V39, P3
   Corbett J., 2007, HLTH CARE PROVISION
   Dalton C., 2011, BR J LEARN DISABIL, V13
   DECHILLO N, 1994, AM J ORTHOPSYCHIAT, V64, P564, DOI 10.1037/h0079572
   Department of Health, 2001, INV PAT PUBL HEALTHC
   Department of Health, 2010, ESS CAR 2010
   Department of Health, 2001, CM5086
   Department of Health, 2007, VALUING PEOPL NOW NE
   Department of Health, 2010, NHS CONST NHS BEL US
   Department of Health, 2009, PUTT PEOPL HEART CAR
   Gilbert T, 2004, HEALTH SOC CARE COMM, V12, P298, DOI 10.1111/j.1365-2524.2004.00499.x
   Gillott Alinda, 2007, J Intellect Disabil, V11, P359, DOI 10.1177/1744629507083585
   GREENFIELD S, 1988, J GEN INTERN MED, V3, P448, DOI 10.1007/BF02595921
   Ingham B, 2008, BRIT J DEV DISABIL, V54, P41
   Ingham B., 2009, CLIN PSYCHOL FORUM, V204, P30
   Lachapelle Y, 2005, J INTELL DISABIL RES, V49, P740, DOI 10.1111/j.1365-2788.2005.00743.x
   Lisle Angela Mary, 2007, J Intellect Disabil, V11, P23, DOI 10.1177/1744629507073997
   Lloyd M, 1996, DISABIL SOC, V11, P301, DOI 10.1080/09687599627624
   McClimens A, 2011, NURS ETHICS, V18, P633, DOI 10.1177/0969733011404588
   Mencap, 2007, DEATH IND
   Mencap, 2012, DEATH IND 74 DEATHS
   Mindham J, 2003, J INTELL DISABIL RES, V47, P22, DOI 10.1046/j.1365-2788.2003.00457.x
   MURPHY J, 2008, BRIT J LEARN DISABIL, V36, P232, DOI 10.1111/j.1468-3156.2008.00490.x
   O'Neill R. E., 1997, FUNCTIONAL ASSESSMEN, V2nd
   Ogden J, 2010, SOCIOL HEALTH ILL, V32, P1059, DOI 10.1111/j.1467-9566.2010.01272.x
   Parkes C., 2007, BRIT J LEARN DISABIL, V35, P23, DOI 10.1111/j.1468-3156.2006.00419.x
   Parley F, 2001, J LEARNING DISABILIT, V5, P299, DOI 10.1177/146900470100500402
   Rojahn J, 2012, J INTELL DISABIL RES, V56, P546, DOI 10.1111/j.1365-2788.2011.01506.x
   SCHUMAN H, 1979, AM SOCIOL REV, V44, P692, DOI 10.2307/2094521
   Scottish Executive, 2001, PAT FOC PUBL INV
   Sharman SJ, 2012, APPL COGNITIVE PSYCH, V26, P48, DOI 10.1002/acp.1793
   Simons K., 1999, PLACE TABLE
   Smiley E., 2011, J INTELL DISABIL RES, V55, P230
   Stancliffe RJ, 2008, J INTELLECT DEV DIS, V33, P196, DOI 10.1080/13668250802315397
   Stribling P, 2007, INT J LANG COMM DIS, V42, P427, DOI 10.1080/13682820601183659
   Tasky KK, 2008, J APPL BEHAV ANAL, V41, P261, DOI 10.1901/jaba.2008.41-261
   Ulke-Kurkcuoglu B, 2010, J APPL BEHAV ANAL, V43, P717, DOI 10.1901/jaba.2010.43-717
   VanBourgondien ME, 1996, J REHABIL, V62, P65
   Walmsley J., 2003, INCLUSIVE RES PEOPLE
   Waltz M., 2007, INT J RES METHOD ED, V30, P353, DOI 10.1080/17437270701614840
   Watanabe M, 2003, J AUTISM DEV DISORD, V33, P535, DOI 10.1023/A:1025835729718
   Whitehurst T., 2006, BR J LEARN DISABIL, V35, P55
   Young AF, 2006, BRIT J LEARN DISABIL, V34, P11
NR 53
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1354-4187
EI 1468-3156
J9 BRIT J LEARN DISABIL
JI Brit. J. Learn. Disabil.
PD SEP
PY 2014
VL 42
IS 3
BP 177
EP 184
DI 10.1111/bld.12026
PG 8
WC Education, Special
SC Education & Educational Research
GA AN4BW
UT WOS:000340533600002
ER

PT J
AU Horan, W
   Pineda, J
   Wynn, J
   Iacoboni, M
   Green, M
AF Horan, William P.
   Pineda, Jaime A.
   Wynn, Jonathan K.
   Iacoboni, Marco
   Green, Michael F.
TI Some markers of mirroring appear intact in schizophrenia: evidence from
   mu suppression
SO COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE mu suppression; Schizophrenia; Mirror neuron system; Empathy
ID AUTISM SPECTRUM DISORDERS; PSYCHIATRIC RATING-SCALE; BORDERLINE
   PERSONALITY-DISORDER; SOCIAL COGNITION; NEURON DYSFUNCTION; EMPATHIC
   ACCURACY; IMITATION; NEUROSCIENCE; MECHANISMS; PSYCHOSIS
AB Although schizophrenia is associated with impairments in social cognition, the scope and neural correlates of these disturbances are largely unknown. In this study, we investigated whether schizophrenia patients show impaired functioning of the mirror neuron system (MNS), as indexed by electroencephalographic (EEG) mu (8-13 Hz) suppression, a hypothesized biomarker of MNS activity that is sensitive to the degree of social interaction depicted in visual stimuli. A total of 32 outpatients and 26 healthy controls completed an EEG paradigm that included six action observation or execution conditions that differed in their degrees of social interaction. Participants also completed a validated empathy questionnaire. Across both groups, we found a significant linear increase in mu suppression across the conditions involving greater levels of social engagement and interaction, but no significant group or interaction effects. Patients self-reported diminished empathic concern and perspective taking, which showed some moderate relations to mu suppression levels. Thus, the schizophrenia group showed generally intact modulation of MNS functioning at the electrophysiological level, despite self-reporting empathic disturbances. The disturbances commonly seen on self-report, performance, and neuroimaging measures of mentalizing in schizophrenia may largely reflect difficulties with higher-level inferential processes about others' emotions, rather than a basic incapacity to share in these experiences.
C1 [Horan, William P.; Wynn, Jonathan K.; Green, Michael F.] Univ Calif Los Angeles, VA Greater Angeles Healthcare Syst, Los Angeles, CA 90073 USA.
   [Pineda, Jaime A.] Univ Calif San Diego, San Diego, CA 92103 USA.
   [Iacoboni, Marco] Univ Calif Los Angeles, Los Angeles, CA USA.
RP Horan, W (reprint author), Univ Calif Los Angeles, VA Greater Angeles Healthcare Syst, MIRECC 210A,Bldg 210,11301 Wilshire Blvd, Los Angeles, CA 90073 USA.
EM horan@ucla.edu
FU Abbott Laboratories; Amgen; Cypress; Lundbeck; Teva; Otsuka; Sunovion;
   VA Career Development Award; NIMH [MH065707, MH43292]
FX M.F.G. reports having received consulting fees from Abbott Laboratories,
   Amgen, Cypress, Lundbeck, and Teva. He has received speaking fees from
   Otsuka and Sunovion. The rest of the authors report no biomedical
   financial interests or potential conflicts of interest. Support for this
   study came from a VA Career Development Award (to W. P. H.) and from
   NIMH Grant Nos. MH065707 and MH43292 (M. F. G.). The authors thank
   Amanda Bender, Michelle Dolinsky, Crystal Gibson, Cory Tripp, and
   Katherine Weiner for assistance in the data collection.
CR Achim AM, 2011, PSYCHIAT RES, V190, P3, DOI 10.1016/j.psychres.2010.10.030
   Bora E, 2009, SCHIZOPHR RES, V109, P1, DOI 10.1016/j.schres.2008.12.020
   Brunet-Gouet E, 2011, PSYCHIAT RES, V190, P23, DOI 10.1016/j.psychres.2010.11.029
   Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
   Caspers S, 2010, NEUROIMAGE, V50, P1148, DOI 10.1016/j.neuroimage.2009.12.112
   Cheng YW, 2012, DEV PSYCHOPATHOL, V24, P623, DOI 10.1017/S095457941200020X
   Chung YS, 2014, SCHIZOPHRENIA BULL, V40, P602, DOI 10.1093/schbul/sbt048
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Davis MC, 2013, SCHIZOPHR RES, V147, P393, DOI 10.1016/j.schres.2013.04.023
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   Decety J, 2010, DEV NEUROSCI-BASEL, V32, P257, DOI 10.1159/000317771
   Derntl B, 2012, SCHIZOPHR RES, V136, P70, DOI 10.1016/j.schres.2011.12.018
   Dziobek I, 2011, NEUROIMAGE, V57, P539, DOI 10.1016/j.neuroimage.2011.05.005
   Enticott PG, 2008, SCHIZOPHR RES, V102, P116, DOI 10.1016/j.schres.2008.04.001
   Ferrari PF, 2012, J COGNITIVE NEUROSCI, V24, P1165, DOI 10.1162/jocn_a_00198
   First M. B., 1994, STRUCTURED CLIN INTE
   First M. B., 1996, STRUCTURED CLIN INTE
   Frith CD, 1996, PSYCHOL MED, V26, P521
   GRATTON G, 1983, ELECTROEN CLIN NEURO, V55, P468, DOI 10.1016/0013-4694(83)90135-9
   Green MF, 2012, ARCH GEN PSYCHIAT, V69, P1216, DOI 10.1001/archgenpsychiatry.2012.652
   Green MF, 2010, CURR DIR PSYCHOL SCI, V19, P243, DOI 10.1177/0963721410377600
   Harvey PO, 2013, SCHIZOPHRENIA BULL, V39, P617, DOI 10.1093/schbul/sbs042
   Horan WP, 2011, J PSYCHIATR RES, V45, P1113, DOI 10.1016/j.jpsychires.2011.01.015
   Iacoboni M, 2001, P NATL ACAD SCI USA, V98, P13995, DOI 10.1073/pnas.241474598
   Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
   Iacoboni M, 2009, ANNU REV PSYCHOL, V60, P653, DOI 10.1146/annurev.psych.60.110707.163604
   Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
   Kern RS, 2013, SCHIZOPHRENIA BULL, V39, P1201, DOI 10.1093/schbul/sbt127
   Kim J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019971
   Kohler CG, 2008, SCHIZOPHR RES, V105, P49, DOI 10.1016/j.schres.2008.05.010
   Kopelowicz A, 2008, PSYCHOPATHOLOGY, V41, P77, DOI 10.1159/000111551
   Kurtz MM, 2012, SCHIZOPHRENIA BULL, V38, P1092, DOI 10.1093/schbul/sbr036
   Lee J, 2011, PSYCHOL MED, V41, P2297, DOI 10.1017/S0033291711000614
   Lieberman MD, 2007, ANNU REV PSYCHOL, V58, P259, DOI 10.1146/annurev.psych.58.110405.085654
   LUKOFF D, 1986, SCHIZOPHRENIA BULL, V12, P578
   Marsh AA, 2013, J CHILD PSYCHOL PSYC, V54, P900, DOI 10.1111/jcpp.12063
   Matthews N, 2013, SCHIZOPHRENIA BULL, V39, P94, DOI 10.1093/schbul/sbr062
   McCormick LM, 2012, PSYCHIAT RES-NEUROIM, V201, P233, DOI 10.1016/j.pscychresns.2012.01.004
   MCPHEETERS HL, 1984, COMMUNITY MENT HLT J, V20, P44
   Meffert H, 2013, BRAIN, V136, P2550, DOI 10.1093/brain/awt190
   Mehta UM, 2012, SCHIZOPHR RES, V141, P281, DOI 10.1016/j.schres.2012.07.005
   Moore A, 2012, BEHAV BRAIN RES, V226, P309, DOI 10.1016/j.bbr.2011.07.048
   Muthukumaraswamy SD, 2004, COGNITIVE BRAIN RES, V19, P195, DOI 10.1016/j.cogbrainres.2003.12.001
   Oberman LM, 2013, SOC COGN AFFECT NEUR, V8, P300, DOI 10.1093/scan/nsr097
   Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
   Oberman LM, 2007, SOC COGN AFFECT NEUR, V2, P62, DOI 10.1093/scan/nsl022
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   OVERALL JE, 1962, PSYCHOL REP, V10, P799
   Park S, 2008, SCHIZOPHRENIA BULL, V34, P698, DOI 10.1093/schbul/sbn048
   Perkins T, 2010, J CLIN NEUROSCI, V17, P1239, DOI 10.1016/j.jocn.2010.01.026
   Pineda JA, 2005, BRAIN RES REV, V50, P57, DOI 10.1016/j.brainresrev.2005.04.005
   Quintana J, 2001, NEUROPSYCHOPHARMACOL, V25, P915, DOI 10.1016/S0893-133X(01)00304-9
   Ripoll LH, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-012-0344-1
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Roberts DL, 2009, PSYCHIAT RES, V166, P141, DOI 10.1016/j.psychres.2008.02.007
   Savla G. N., 2012, SCHIZOPHRENIA B, V39, P979, DOI [10.1093/schbul/sbs080, DOI 10.1093/SCHBUL/SBS080]
   Schurmann M, 2007, BRIT J PSYCHIAT, V191, P178, DOI 10.1192/bjp.jp.106.024604
   Singh F, 2011, SCHIZOPHR RES, V130, P182, DOI 10.1016/j.schres.2011.04.004
   Smith MJ, 2014, SCHIZOPHRENIA BULL, V40, P824, DOI 10.1093/schbul/sbt084
   Smith MJ, 2012, SCHIZOPHR RES, V137, P196, DOI 10.1016/j.schres.2012.01.012
   Tschacher W, 2006, SCHIZOPHRENIA BULL, V32, pS106, DOI 10.1093/schbul/sb1018
   Varcin KJ, 2010, J INT NEUROPSYCH SOC, V16, P621, DOI 10.1017/S1355617710000329
   VENTURA J, 1993, INT J METH PSYCH RES, V3, P221
   Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
   Woodruff CC, 2011, BRAIN RES, V1405, P69, DOI 10.1016/j.brainres.2011.05.046
   Zaki J, 2012, NAT NEUROSCI, V15, P675, DOI 10.1038/nn.3085
   Zaki J, 2011, PSYCHOL INQ, V22, P159, DOI 10.1080/1047840X.2011.551743
NR 68
TC 2
Z9 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1530-7026
EI 1531-135X
J9 COGN AFFECT BEHAV NE
JI Cogn. Affect. Behav. Neurosci.
PD SEP
PY 2014
VL 14
IS 3
BP 1049
EP 1060
DI 10.3758/s13415-013-0245-8
PG 12
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AN3FT
UT WOS:000340471500013
PM 24415272
ER

PT J
AU Radell, M
   Mercado, E
AF Radell, Milen L.
   Mercado, Eduardo, III
TI Modeling possible effects of atypical cerebellar processing on eyeblink
   conditioning in autism
SO COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE Classical conditioning; Cerebellum; Computational model; Autistic;
   Interneuron; Timing
ID PARALLEL FIBER SYNAPSES; PURKINJE-CELL ACTIVITY; LONG-TERM DEPRESSION;
   FRAGILE-X-SYNDROME; SPECTRUM DISORDERS; ALZHEIMERS-DISEASE;
   NEUROPSYCHIATRIC DISORDERS; FUNCTIONAL SPECIALIZATION; ASCENDING AXON;
   NETWORK MODEL
AB Autism is unique among other disorders in that acquisition of conditioned eyeblink responses is enhanced in children, occurring in a fraction of the trials required for control participants. The timing of learned responses is, however, atypical. Two animal models of autism display a similar phenotype. Researchers have hypothesized that these differences in conditioning reflect cerebellar abnormalities. The present study used computer simulations of the cerebellar cortex, including inhibition by the molecular layer interneurons, to more closely examine whether atypical cerebellar processing can account for faster conditioning in individuals with autism. In particular, the effects of inhibitory levels on delay eyeblink conditioning were simulated, as were the effects of learning-related synaptic changes at either parallel fibers or ascending branch synapses from granule cells to Purkinje cells. Results from these simulations predict that whether molecular layer inhibition results in an enhancement or an impairment of acquisition, or changes in timing, may depend on (1) the sources of inhibition, (2) the levels of inhibition, and (3) the locations of learning-related changes (parallel vs. ascending branch synapses). Overall, the simulations predict that a disruption in the balance or an overall increase of inhibition within the cerebellar cortex may contribute to atypical eyeblink conditioning in children with autism and in animal models of autism.
C1 [Radell, Milen L.; Mercado, Eduardo, III] SUNY Buffalo, Dept Psychol, Buffalo, NY 14260 USA.
RP Radell, M (reprint author), SUNY Buffalo, Dept Psychol, Pk Hall, Buffalo, NY 14260 USA.
EM mlradell@buffalo.edu
FU NSF [SMA-1041755]
FX This work was supported in part by a grant to E. Mercado, from NSF grant
   #SMA-1041755 to the Temporal Dynamics of Learning Center, an NSF Science
   of Learning Center.
CR Allen G, 2006, CLIN NEUROSCI RES, V6, P195, DOI 10.1016/j.cnr.2006.06.002
   Arndt TL, 2005, INT J DEV NEUROSCI, V23, P189, DOI 10.1016/j.ijdevneu.2004.11.001
   Bauman ML, 1997, INT REV NEUROBIOL, V41, P367
   Beylin AV, 2001, NEUROBIOL LEARN MEM, V76, P447, DOI 10.1006/nlme.2001.4039
   Blatt GJ, 2011, ANAT REC, V294, P1646, DOI 10.1002/ar.21252
   Bower JM, 2010, FRONT CELL NEUROSCI, V4, DOI 10.3389/fncel.2010.00027
   Bower JM, 2002, ANN NY ACAD SCI, V978, P135, DOI 10.1111/j.1749-6632.2002.tb07562.x
   Bower JM, 1997, INT REV NEUROBIOL, V41, P489
   BUONOMANO DV, 1994, NEURAL COMPUT, V6, P38, DOI 10.1162/neco.1994.6.1.38
   Chattopadhyaya Bidisha, 2012, Front Psychiatry, V3, P51, DOI 10.3389/fpsyt.2012.00051
   Chen C, 1995, CELL, V83, P1233, DOI 10.1016/0092-8674(95)90148-5
   Cheng DT, 2008, P NATL ACAD SCI USA, V105, P8108, DOI 10.1073/pnas.0800374105
   Chu CP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037031
   Chukoskie L, 2013, INT REV NEUROBIOL, V113, P207, DOI 10.1016/B978-0-12-418700-9.00007-1
   COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
   Cramer SW, 2013, J NEUROSCI, V33, P11412, DOI 10.1523/JNEUROSCI.0711-13.2013
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   Dawson M., 2008, COGNITIVE PSYCHOL, V2, P759
   Dovgopoly A, 2013, COGN AFFECT BEHAV NE, V13, P371, DOI 10.3758/s13415-012-0148-0
   Forsyth JK, 2012, SCHIZOPHRENIA BULL, V38, P751, DOI 10.1093/schbul/sbq148
   Freeman JH, 2011, LEARN MEMORY, V18, P666, DOI 10.1101/lm.2023011
   GLUCK MA, 1993, HIPPOCAMPUS, V3, P491, DOI 10.1002/hipo.450030410
   Gowen E, 2007, CEREBELLUM, V6, P268, DOI 10.1080/14734220601184821
   Green JT, 2005, LEARN MEMORY, V12, P260, DOI 10.1101/lm.89505
   Grossberg S, 2006, PSYCHOL REV, V113, P483, DOI 10.1037/0033-295X.113.3.483
   Harris NS, 1999, COGNITIVE BRAIN RES, V8, P61, DOI 10.1016/S0926-6410(99)00006-3
   Hong S., 2008, PLOS ONE, V3, P1
   Hoppenbrouwers SS, 2008, BRAIN RES REV, V59, P185, DOI 10.1016/j.brainresrev.2008.07.005
   Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
   Ito M, 2006, PROG NEUROBIOL, V78, P272, DOI 10.1016/j.pneurobio.2006.02.006
   Itzchak E.-B., 2013, RES AUTISM SPECT DIS, V7, P1122
   JAKUBOWSKA E, 1978, ACTA NEUROBIOL EXP, V38, P1
   Jirenhed DA, 2011, CEREBELLUM, V10, P523, DOI 10.1007/s12311-011-0264-3
   Kapur N, 1996, BRAIN, V119, P1775, DOI 10.1093/brain/119.5.1775
   Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005
   Manto M, 2012, CEREBELLUM, V11, P457, DOI 10.1007/s12311-011-0331-9
   Marcaggi P, 2007, J PHYSIOL-LONDON, V578, P545, DOI 10.1113/jphysiol.2006.115014
   Medina JF, 2000, NAT NEUROSCI, V3, P1205, DOI 10.1038/81486
   Miller LK, 1999, PSYCHOL BULL, V125, P31, DOI 10.1037/0033-2909.125.1.31
   Molinari M, 2008, CEREBELLUM, V7, P611, DOI 10.1007/s12311-008-0060-x
   Molinari M, 2002, NEUROSCIENCE, V111, P863, DOI 10.1016/S0306-4522(02)00024-6
   Moustafa AA, 2013, BRAIN RES, V1493, P48, DOI 10.1016/j.brainres.2012.11.020
   Murawski NJ, 2009, BEHAV BRAIN RES, V196, P297, DOI 10.1016/j.bbr.2008.09.020
   Nawrocki RA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045581
   OHLRICH ES, 1968, J EXP CHILD PSYCHOL, V6, P181, DOI 10.1016/0022-0965(68)90083-0
   Oristaglio J, 2013, NEUROSCIENCE, V248, P708, DOI 10.1016/j.neuroscience.2013.06.007
   Parsons LM, 2009, BRAIN RES, V1303, P84, DOI 10.1016/j.brainres.2009.09.052
   Penn HE, 2006, CHILD NEUROPSYCHOL, V12, P57, DOI 10.1080/09297040500253546
   Petacchi A, 2005, HUM BRAIN MAPP, V25, P118, DOI 10.1002/hbm.20137
   Reeb-Sutherland BC, 2015, J AUTISM DEV DISORD, V45, P376, DOI 10.1007/s10803-013-1905-9
   Requarth T, 2011, CURR OPIN NEUROBIOL, V21, P602, DOI 10.1016/j.conb.2011.05.031
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Santamaria F, 2007, J NEUROPHYSIOL, V97, P248, DOI 10.1152/jn.01098.2005
   SCAVIO MJ, 1974, PAVLOVIAN J BIOL SCI, V9, P25
   Schroeder JH, 2010, RES AUTISM SPECT DIS, V4, P555, DOI 10.1016/j.rasd.2010.01.004
   Sears L. L., 2000, APPL HUMANS, VI, P143
   Sears LL, 2004, INTEGR PHYS BEH SCI, V39, P70
   SEARS LL, 1994, J AUTISM DEV DISORD, V24, P737, DOI 10.1007/BF02172283
   Sims RE, 2005, J NEUROSCI, V25, P3246, DOI 10.1523/JNEUROSCI.0073-05.2005
   Sims RE, 2006, J NEUROSCI, V26, P5153, DOI 10.1523/JNEUROSCI.4121-05.2006
   Stanton ME, 2007, BEHAV BRAIN RES, V176, P133, DOI 10.1016/j.bbr.2006.10.022
   Steinmetz JE, 2001, INTEGR PHYS BEH SCI, V36, P220, DOI 10.1007/BF02734095
   Sultan F, 1998, J COMP NEUROL, V393, P353
   Thompson RF, 2009, NEUROSCIENCE, V162, P732, DOI 10.1016/j.neuroscience.2009.01.041
   Tiemeier H, 2010, NEUROIMAGE, V49, P63, DOI 10.1016/j.neuroimage.2009.08.016
   Tobia MJ, 2009, BEHAV NEUROSCI, V123, P665, DOI 10.1037/a0015662
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Vattikuti S, 2010, BIOL PSYCHIAT, V67, P672, DOI 10.1016/j.biopsych.2009.09.008
   Welsh JP, 2005, INT J DEV NEUROSCI, V23, P253, DOI 10.1016/j.ijdevneu.2004.09.002
   Whitney ER, 2009, J NEUROSCI RES, V87, P2245, DOI 10.1002/jnr.22056
   Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y
   Whyatt C, 2013, FRONT INTEGR NEUROSC, V7, P1, DOI DOI 10.3389/FNINT.2013.00051
   Wimpory D, 2002, J INTELL DISABIL RES, V46, P352, DOI 10.1046/j.1365-2788.2002.00423.x
   Woodruff-Pak DS, 2008, TRENDS NEUROSCI, V31, P105, DOI 10.1016/j.tins.2007.11.006
   WoodruffPak DS, 1996, BEHAV NEUROSCI, V110, P22
   WoodruffPak DS, 1996, NEUROBIOL AGING, V17, P505
   Woodruff-Pak DS, 2001, INTEGR PHYS BEH SCI, V36, P87, DOI 10.1007/BF02734044
   Yamazaki T, 2007, EUR J NEUROSCI, V26, P2279, DOI 10.1111/j.1460-9568.2007.05837.x
   Yamazaki T, 2007, NEURAL NETWORKS, V20, P290, DOI 10.1016/j.neunet.2007.04.004
   Yamazaki T, 2009, CEREBELLUM, V8, P423, DOI 10.1007/s12311-009-0115-7
   Yamazaki T, 2005, NEURAL COMPUT, V17, P1032, DOI 10.1162/0899766053491850
   Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
   Yip J, 2008, J NEUROSCI RES, V86, P525, DOI 10.1002/jnr.21520
NR 83
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1530-7026
EI 1531-135X
J9 COGN AFFECT BEHAV NE
JI Cogn. Affect. Behav. Neurosci.
PD SEP
PY 2014
VL 14
IS 3
BP 1142
EP 1164
DI 10.3758/s13415-014-0263-1
PG 23
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AN3FT
UT WOS:000340471500020
PM 24590391
ER

PT J
AU Ostuzzi, G
   Barbui, C
AF Ostuzzi, G.
   Barbui, C.
TI Autism spectrum disorders: weighing the risk of SSRI exposure in
   pregnancy
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE Autism spectrum disorders; maternal depression; pregnancy; selective
   serotonin reuptake inhibitors..
ID ANTIDEPRESSANT USE
AB A possible link between prenatal exposure to the selective serotonin reuptake inhibitors (SSRIs) and development of autism spectrum disorders (ASDs), previously suggested by two case-control studies, was not confirmed by a recent cohort study that followed for 5-10 years more than 600,000 births. However, this study failed to demonstrate that SSRI exposure during pregnancy is safe in terms of child development outcomes, as an increased risk of ASDs cannot be completely ruled out. In the present article, the main strengths and weaknesses of this study are briefly analysed, including a possibility of confounding by indication.
C1 [Ostuzzi, G.; Barbui, C.] Univ Verona, Dept Publ Hlth & Community Med, Sect Psychiat, I-37134 Verona, Italy.
RP Barbui, C (reprint author), Univ Verona, Dept Publ Hlth & Community Med, Sect Psychiat, Piazzale LA Scuro 10, I-37134 Verona, Italy.
EM corrado.barbui@univr.it
CR Barbui C, 2013, EPIDEMIOL PSYCH SCI, V22, P307, DOI 10.1017/S2045796013000358
   Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73
   Grigoriadis S, 2013, J CLIN PSYCHIAT, V74, P321
   Hviid A, 2013, NEW ENGL J MED, V369, P2406, DOI 10.1056/NEJMoa1301449
   Maenner MJ, 2013, J AM ACAD CHILD PSY, V52, P401, DOI 10.1016/j.jaac.2013.01.014
   Neuhaus E, 2010, CLIN PSYCHOL REV, V30, P733, DOI 10.1016/j.cpr.2010.05.007
   Rai D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2059
   Rezendes DL, 2011, AUTISM RES TREATMENT, DOI [10.1155/2011/395190, DOI 10.1155/2011/395190]
   Ross LE, 2013, JAMA PSYCHIAT, V70, P436, DOI 10.1001/jamapsychiatry.2013.684
   Salas M, 1999, AM J EPIDEMIOL, V149, P981
NR 10
TC 1
Z9 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
EI 2045-7979
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PD SEP
PY 2014
VL 23
IS 3
BP 231
EP 233
DI 10.1017/S2045796014000286
PG 3
WC Psychiatry
SC Psychiatry
GA AN2FR
UT WOS:000340400000005
PM 24786563
ER

PT J
AU Calderoni, S
   Bellani, M
   Hardan, AY
   Muratori, F
   Brambilla, P
AF Calderoni, S.
   Bellani, M.
   Hardan, A. Y.
   Muratori, F.
   Brambilla, P.
TI Basal ganglia and restricted and repetitive behaviours in Autism
   Spectrum Disorders: current status and future perspectives
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE Autism spectrum disorders (ASD); basal ganglia; structural magnetic
   resonance imaging (sMRI); volumes
ID CAUDATE-NUCLEUS; BRAIN ANATOMY; VOLUME; PERFORMANCE; STRIATUM; FOCUS
AB This editorial offers a concise overview of the recent structural magnetic resonance imaging studies that evaluate the basal ganglia (BG) volumes in autism spectrum disorders (ASD). The putative relationship between the repetitive or stereotyped behaviours of ASD and BG volumes is also explored, with a focus on possible translational approaches.
C1 [Calderoni, S.; Muratori, F.] IRCCS Stella Maris Fdn, Pisa, Italy.
   [Bellani, M.] Univ Verona, ICBN, Dept Publ Hlth & Community Med, Sect Psychiat, I-37100 Verona, Italy.
   [Bellani, M.] Univ Verona, ICBN, Sect Clin Psychol, I-37100 Verona, Italy.
   [Hardan, A. Y.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Muratori, F.] Univ Pisa, Dept Clin & Expt Med, I-56100 Pisa, Italy.
   [Brambilla, P.] Univ Udine, ICBN, Dept Expt & Clin Med, I-33100 Udine, Italy.
   [Brambilla, P.] UDGEE, IRCCS E Medea Sci Inst, Udine, Italy.
RP Bellani, M (reprint author), Univ Verona, Dept Publ Hlth & Community Med, Sect Psychiat, Piazzale LA Scuro 10, I-37134 Verona, Italy.
EM marcella.bellani@univr.it
FU Italian Ministry of Health; Tuscany Region [GR-2010-2317873]; European
   Union
FX S. C. was partly supported by the Italian Ministry of Health and by
   Tuscany Region with the grant 'GR-2010-2317873'. F. M. and S. C. were
   partly supported by the European Union (The MICHELANGELO Project). The
   other authors received no specific grant from any funding agency,
   commercial or not-for-profit sectors for this publication.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Bellani M, 2013, EPIDEMIOL PSYCH SCI, V22, P309, DOI 10.1017/S2045796013000346
   Bellani M, 2013, EPIDEMIOL PSYCH SCI, V22, P217, DOI 10.1017/S2045796013000139
   Estes A, 2011, AUTISM RES, V4, P212, DOI 10.1002/aur.193
   Hardan AY, 2003, J CHILD NEUROL, V18, P317, DOI 10.1177/08830738030180050801
   Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   Langen M, BIOL PSYCHI IN PRESS
   Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Voelbel GT, 2006, BIOL PSYCHIAT, V60, P942, DOI 10.1016/j.biopsych.2006.03.071
   Wolff JJ, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-12
NR 14
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
EI 2045-7979
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PD SEP
PY 2014
VL 23
IS 3
BP 235
EP 238
DI 10.1017/S2045796014000171
PG 4
WC Psychiatry
SC Psychiatry
GA AN2FR
UT WOS:000340400000006
PM 24816251
ER

PT J
AU Witmer, SE
   Ferreri, SJ
AF Witmer, Sara E.
   Ferreri, Summer J.
TI Alignment of Instruction, Expectations, and Accountability Testing for
   Students With Autism Spectrum Disorder
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE assessment; inclusion; instruction
ID OBJECTIVE DATA SOURCES; TEST ACCOMMODATIONS; TEACHER JUDGMENTS;
   DISABILITIES; PARTICIPATION; PERFORMANCE; MATHEMATICS; STANDARDS;
   MODERATE; CHILDREN
AB Current large-scale assessment and accountability policies in the United States emphasize the need for all students to be appropriately included. However, there are many challenges to effective inclusion. Students with autism spectrum disorder (ASD) exhibit unique social communication and behavior challenges that can hinder their effective inclusion in instruction and testing. However, no studies have systematically examined how this unique group of students is currently included in accountability programs. A statewide representative sample of 191 teachers selected a student with ASD and reported on (a) the extent to which the student received instruction according to the general curriculum, (b) the teacher's academic expectations for the student, and (c) the method by which the student participated in accountability testing. Results indicated that many students were reported to rarely receive instruction according to the general curriculum, and many were reported to participate in an alternate assessment.
C1 [Witmer, Sara E.; Ferreri, Summer J.] Michigan State Univ, E Lansing, MI 48824 USA.
RP Witmer, SE (reprint author), Michigan State Univ, 620 Farm Lane,Rm 434, E Lansing, MI 48824 USA.
EM sbolt@msu.edu
CR Agran M, 2002, EDUC TRAIN MENT RET, V37, P123
   Altman J., 2008, 70 U MINN NAT CTR ED
   Browder D. M., 2011, TEACHING STUDENTS MO
   Browder DM, 2012, J SPEC EDUC, V46, P26, DOI 10.1177/0022466910369942
   Carr-George C, 2009, BEHAV DISORDERS, V35, P66
   Christenson SL, 2007, EDUC POLICY, V21, P662, DOI 10.1177/0895904806289209
   Collins BC, 2011, EDUC TRAIN AUTISM DE, V46, P22
   Curcic S, 2009, INT J INCLUSIVE EDUC, V13, P517, DOI 10.1080/13603110801899585
   Dempsey I., 2005, AUST J EDUC, V49, P152
   Farrell P., 2009, EUROPEAN J SPECIAL N, V24, P407
   Fuchs LS, 2000, EXCEPT CHILDREN, V67, P67
   Fuchs LS, 2000, SCHOOL PSYCHOL REV, V29, P65
   Herman J. L., 1992, PRACTICAL GUIDE ALTE
   Jennett HK, 2003, J AUTISM DEV DISORD, V33, P583, DOI 10.1023/B:JADD.0000005996.19417.57
   Koegel L, 2012, COGN BEHAV PRACT, V19, P401
   Lazarus SS, 2011, REM SPEC EDUC, V32, P301, DOI 10.1177/0741932510362214
   MCGREW KS, 1993, EDUC EVAL POLICY AN, V15, P339, DOI 10.3102/01623737015003339
   MEYER LH, 1987, J ASSOC PERS SEVERE, V12, P251
   Mitchell P, 1997, J CHILD PSYCHOL PSYC, V38, P685, DOI 10.1111/j.1469-7610.1997.tb01695.x
   Myles B. S., 1999, FOCUS AUTISM OTHER D, V14, P212, DOI 10.1177/108835769901400403
   Olson J. F., 1996, INCREASING INCLUSION, V2
   Rutter M., 1994, CHILD ADOL PSYCH CL, P569
   Ryndak D. L., 2000, EXCEPTIONALITY, V8, P101, DOI 10.1207/S15327035EX0802_2
   Seyfarth A., 1997, 29 U MINN NAT CTR ED
   SRI International, 2003, SPEC ED EL LONG STUD
   Taylor M. F., 2012, AUSTRALASIAN J SPECI, V36, P97
   Temple-Harvey KK, 2012, REM SPEC EDUC, V33, P226, DOI 10.1177/0741932510391815
   Thurlow M. L., 1998, TESTING STUDENTS DIS
   Tindal G, 1998, EXCEPT CHILDREN, V64, P439
   U.S. Department of Education, 2002, NO CHILD LEFT ACT 20
   Weston T., 1999, ANN M AM ED RES ASS
   Ysseldyke J. E., 1994, 13 U MINN NAT CTR ED
NR 32
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2014
VL 29
IS 3
BP 131
EP 144
DI 10.1177/1088357614522294
PG 14
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AN4HA
UT WOS:000340547100001
ER

PT J
AU Ehrenreich-May, J
   Storch, EA
   Queen, AH
   Rodriguez, JH
   Ghilain, CS
   Alessandri, M
   Lewin, AB
   Arnold, EB
   Murphy, TK
   Lin, CE
   Fujii, C
   Renno, P
   Piacentini, J
   Laugeson, E
   Wood, JJ
AF Ehrenreich-May, Jill
   Storch, Eric A.
   Queen, Alexander H.
   Rodriguez, Juventino Hernandez
   Ghilain, Christine S.
   Alessandri, Michael
   Lewin, Adam B.
   Arnold, Elysse B.
   Murphy, Tanya K.
   Lin, C. Enjey
   Fujii, Cori
   Renno, Patricia
   Piacentini, John
   Laugeson, Elizabeth
   Wood, Jeffrey J.
TI An Open Trial of Cognitive-Behavioral Therapy for Anxiety Disorders in
   Adolescents With Autism Spectrum Disorders
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism spectrum disorders; anxiety; comorbid conditions; evidence-based
   practices
ID PERVASIVE DEVELOPMENTAL DISORDERS; OBSESSIVE-COMPULSIVE DISORDER;
   RANDOMIZED CONTROLLED-TRIAL; ASPERGER-SYNDROME; PSYCHOSOCIAL TREATMENTS;
   INTERVIEW SCHEDULE; DSM-IV; CHILDHOOD ANXIETY; PARENT VERSION; CHILDREN
AB The frequent co-occurrence of anxiety disorders and autism spectrum disorders (ASD) in youth has spurred study of intervention practices for this population. As anxiety disorders in the absence of ASD are effectively treated using cognitive-behavioral therapy (CBT) protocols, an initial step in evaluating treatments for comorbid youth has necessarily centered on adaptation of CBT. One primary limitation of this research, to date, is that interventions for adolescents with anxiety disorders and ASD have not been systematically tested. In this study, 20 adolescents (90% male) with ASD and a comorbid anxiety disorder, between ages 11 and 14 years (M = 12.2 years, SD = 1.11 years), participated in an open trial of modified CBT targeting anxiety with ASD. Findings demonstrated significant reductions in anxiety severity, as assessed by clinician and parent ratings, from baseline to post-treatment. In addition, reductions in parent-rated externalizing symptoms were observed. Gains were maintained at a 1-month follow-up.
C1 Univ Miami, Coral Gables, FL 33146 USA.
   [Ehrenreich-May, Jill; Queen, Alexander H.; Ghilain, Christine S.; Alessandri, Michael] Univ S Florida, Tampa, FL USA.
   [Storch, Eric A.; Lewin, Adam B.; Arnold, Elysse B.; Murphy, Tanya K.] Univ Arkansas, Fayetteville, AR 72701 USA.
   [Rodriguez, Juventino Hernandez; Lin, C. Enjey; Fujii, Cori; Renno, Patricia; Piacentini, John; Laugeson, Elizabeth; Wood, Jeffrey J.] Univ Calif Los Angeles, Los Angeles, CA USA.
RP Ehrenreich-May, J (reprint author), Univ Miami, Dept Psychol, 5665 Ponce de Leon Blvd,Room 315, Coral Gables, FL 33146 USA.
EM j.ehrenreich@miami.edu
CR Achenbach T. M., 2001, ASEBA SCH AGE FORMS
   Achenbach TM, 1995, PSYCHOL ASSESSMENT, V7, P261, DOI 10.1037/1040-3590.7.3.261
   Achenbach TM, 2003, J CLIN CHILD ADOLESC, V32, P328, DOI 10.1207/S15374424JCCP3203_02
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Attwood T, 2003, CHILD ADOL PSYCH CL, V12, P65, DOI 10.1016/S1056-4993(02)00054-8
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Chorpita BF, 2000, BEHAV RES THER, V38, P835, DOI 10.1016/S0005-7967(99)00130-8
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   David-Ferdon C, 2008, J CLIN CHILD ADOLESC, V37, P62, DOI 10.1080/15374410701817865
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Enders CK, 2010, APPL MISSING DATA AN
   Essau CA, 2002, J ANXIETY DISORD, V16, P67, DOI 10.1016/S0887-6185(01)00091-3
   Eyberg SM, 2008, J CLIN CHILD ADOLESC, V37, P215, DOI 10.1080/15374410701820117
   Franco X, 2007, J ANXIETY DISORD, V21, P717, DOI 10.1016/j.janxdis.2006.10.002
   Franklin ME, 2011, JAMA-J AM MED ASSOC, V306, P1224, DOI 10.1001/jama.2011.1344
   Ginsburg GS, 2011, J CONSULT CLIN PSYCH, V79, P806, DOI 10.1037/a0025933
   Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
   Guy W, 1976, DHEW PUBL, V338, P218
   Henry CA, 2006, J CHILD ADOL PSYCHOP, V16, P187, DOI 10.1089/cap.2006.16.187
   Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Kearney CA, 2007, J CHILD PSYCHOL PSYC, V48, P53, DOI 10.1111/j.1469-7610.2006.01634.x
   Keller MB, 2000, NEW ENGL J MED, V342, P1462, DOI 10.1056/NEJM200005183422001
   Kelly AB, 2008, J ABNORM CHILD PSYCH, V36, P1069, DOI 10.1007/s10802-008-9234-8
   Kendall PC, 2008, J CONSULT CLIN PSYCH, V76, P282, DOI 10.1037/0022-006X.76.2.282
   Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Langley AK, 2004, J CHILD ADOL PSYCHOP, V14, P105, DOI 10.1089/104454604773840544
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lyneham HJ, 2007, J AM ACAD CHILD PSY, V46, P731, DOI 10.1097/chi.0b013e318046a09
   March J, 2004, JAMA-J AM MED ASSOC, V292, P807
   McDonough J. T., 2010, J VOCATIONAL REHABIL, V32, P81, DOI DOI 10.3233/JVR-2010-0503
   Meyer JA, 2006, AUTISM, V10, P383, DOI 10.1177/1362361306064435
   Mills R., 2005, ANN M NAT AUT SOC LO
   Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
   Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303
   Pediatric OCD Treatment Study Team, 2004, JAMA-J AM MED ASSOC, V292, P1969, DOI DOI 10.1001/JAMA.292.16.1969
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
   Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
   Silverman WK, 2008, J CLIN CHILD ADOLESC, V37, P105, DOI 10.1080/15374410701817907
   Silverman WK, 1996, ANXIETY DISORDERS IN, V1
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Sofronoff K., 2003, GOOD AUTISM PRACTICE, V6, P1
   Storch EA, 2007, BEHAV RES THER, V45, P2593, DOI 10.1016/j.brat.2007.06.001
   Storch EA, 2013, J AM ACAD CHILD PSY, V52, P132, DOI 10.1016/j.jaac.2012.11.007
   Storch EA, 2012, J AUTISM DEV DISORD, V42, P2374, DOI 10.1007/s10803-012-1489-9
   Storch EA, 2010, BIOL PSYCHIAT, V68, P1073, DOI 10.1016/j.biopsych.2010.07.015
   Storch EA, 2012, J CHILD ADOL PSYCHOP, V22, P292, DOI 10.1089/cap.2011.0114
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Sung M, 2011, CHILD PSYCHIAT HUM D, V42, P634, DOI 10.1007/s10578-011-0238-1
   Sze K. M., 2007, J CONTEMP PSYCHOTHER, V37, P133, DOI 10.1007/s10879-007-9048-y
   March JS, 2007, ARCH GEN PSYCHIAT, V64, P1132
   Volkmar F. R., 2000, ASPERGER SYNDROME, V27, P25
   Walkup JT, 2008, NEW ENGL J MED, V359, P2753, DOI 10.1056/NEJMoa0804633
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Weisz JR, 2012, ARCH GEN PSYCHIAT, V69, P274, DOI 10.1001/archgenpsychiatry.2011.147
   Wood J. J., 2008, CHILD ANXIETY DISORD
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JJ, 2009, J AUTISM DEV DISORD, V39, P1608, DOI 10.1007/s10803-009-0791-7
   Zaider TI, 2003, PSYCHOL MED, V33, P611, DOI 10.1017/S0033291703007414
NR 68
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2014
VL 29
IS 3
BP 145
EP 155
DI 10.1177/1088357614533381
PG 11
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AN4HA
UT WOS:000340547100002
ER

PT J
AU Bouck, EC
   Savage, M
   Meyer, NK
   Taber-Doughty, T
   Hunley, M
AF Bouck, Emily C.
   Savage, Melissa
   Meyer, Nancy K.
   Taber-Doughty, Teresa
   Hunley, Megan
TI High-Tech or Low-Tech? Comparing Self-Monitoring Systems to Increase
   Task Independence for Students With Autism
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE high school; age; functional skills; independence; autism spectrum
   disorders; daily living; skills; intellectual disability
ID GENERAL-EDUCATION CLASSROOM; HIGH-SCHOOL; DISABILITIES; PERFORMANCE;
   CHILDREN; ADULTS; SKILLS
AB Independence is the ultimate goal for students with disabilities, including secondary students with autism. One avenue targeted for increasing independence and decreasing prompt-dependency is through self-monitoring. In this study, investigators sought to determine whether a difference exists in levels of task independence when three students with autism complete food preparation tasks while self-monitoring using a low-tech treatment (paper/pencil) and high-tech treatment (iPad). Although both interventions decreased the need for prompting thereby increasing independence, students needed less assistance when using the iPad. Students also maintained their levels of independence in food preparation following summer vacation. Social validity interviews indicated students preferred self-monitoring with the iPad over the paper/pencil.
C1 [Bouck, Emily C.; Savage, Melissa; Meyer, Nancy K.; Taber-Doughty, Teresa; Hunley, Megan] Purdue Univ, W Lafayette, IN 47907 USA.
RP Bouck, EC (reprint author), Purdue Univ, 100 N Univ St, W Lafayette, IN 47907 USA.
EM bouck@purdue.edu
CR Agran M, 2005, EDUC TRAIN DEV DISAB, V40, P3
   Bouck EC, 2012, EDUC TRAIN AUTISM DE, V47, P462
   Bruhn A, 2012, BEHAV DISORDERS, V38, P3
   Cihak DF, 2010, EDUC TRAIN AUTISM DE, V45, P136
   Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749
   Ganz JB, 2005, EDUC TRAIN DEV DISAB, V40, P24
   Garner N., 2003, INT J INCLUSIVE EDUC, V7, P415, DOI 10.1080/1360311032000110963
   Gast D., 2010, SINGLE SUBJECT RES M, P199
   Gast D. L., 2010, SINGLE SUBJECT RES M, P329
   Gast D. L., 2010, SINGLE SUBJECT RES M
   Gulchak D., 2008, EDUC TREAT CHILD, V31, P567
   Harris KR, 2005, J SPEC EDUC, V39, P145, DOI 10.1177/00224669050390030201
   Holifield C, 2010, FOCUS AUTISM DEV DIS, V25, P230, DOI 10.1177/1088357610380137
   Hughes C, 2002, EDUC TRAIN MENT RET, V37, P262
   Hume K, 2009, J AUTISM DEV DISORD, V39, P1329, DOI 10.1007/s10803-009-0751-2
   Kennedy C, 2005, SINGLE CASE DESIGNS
   Kim MC, 2011, COMPUT EDUC, V56, P403, DOI 10.1016/j.compedu.2010.08.024
   Konrad M., 2010, ED TREATMENT CHILDRE, V33, P187
   Lee S. H., 2007, FOCUS AUTISM OTHER D, V22, P2, DOI DOI 10.1177/10883576070220010101
   Legge D. B., 2010, J BEHAV ASSESSMENT I, V1, P43
   Lienemann T. O., 2006, EXCEPT CHILDREN, V76, P471
   Parker D, 2011, FOCUS AUTISM DEV DIS, V26, P131, DOI 10.1177/1088357610376945
   Smith LE, 2012, J AM ACAD CHILD PSY, V51, P622, DOI 10.1016/j.jaac.2012.03.001
   Snell M. E., 2006, INSTRUCTION STUDENTS
   Wehman P., 2006, LIFE CLASSROOM TRANS, P41
   Wehmeyer M. L., 1996, SELF DETERMINATION L, P15
   Wehmeyer ML, 2003, EDUC TRAIN MENT RET, V38, P131
   White O. R., 1980, EXCEPTIONAL TEACHING
NR 28
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2014
VL 29
IS 3
BP 156
EP 167
DI 10.1177/1088357614528797
PG 12
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AN4HA
UT WOS:000340547100003
ER

PT J
AU Rieth, SR
   Stahmer, AC
   Suhrheinrich, J
   Schreibman, L
   Kennedy, J
   Ross, B
AF Rieth, Sarah R.
   Stahmer, Aubyn C.
   Suhrheinrich, Jessica
   Schreibman, Laura
   Kennedy, Joanna
   Ross, Benjamin
TI Identifying Critical Elements of Treatment: Examining the Use of Turn
   Taking in Autism Intervention
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE evidence-based intervention; naturalistic behavioral intervention; turn
   taking; critical elements
AB Evidence-based treatments for autism spectrum disorders (ASD) are comprised of components that identify therapist behavior necessary to implement the treatment with integrity. Some components are shared across approaches from diverse theoretical backgrounds. One component included in several interventions that has not been researched in isolation is turn taking, or the manner in which the therapist facilitates back-and-forth interaction with the child. The current study used an alternating treatments design to examine the efficacy of four types of turn taking. Six children, ages 30 to 39 months, received behavioral treatment while therapists systematically varied the nature of the turn taking component. Children's responses were behaviorally scored to examine differences based on turn condition. Consistent patterns of behavior were found across children. Results suggest that the optimal type of turn is dependent on developmental level and target skill. Implications for treatment of ASD and future research directions are discussed.
C1 [Rieth, Sarah R.; Stahmer, Aubyn C.; Suhrheinrich, Jessica] Rady Childrens Hosp, San Diego, CA 92123 USA.
   [Rieth, Sarah R.; Stahmer, Aubyn C.; Suhrheinrich, Jessica; Schreibman, Laura; Kennedy, Joanna; Ross, Benjamin] Univ Calif San Diego, San Diego, CA 92103 USA.
RP Rieth, SR (reprint author), Rady Childrens Hosp, 3020 Childrens Way,MC 5033, San Diego, CA 92123 USA.
EM sreed@casrc.org
CR ALPERT CL, 1992, J EARLY INTERVENTION, V16, P31
   BARLOW DH, 1979, J APPL BEHAV ANAL, V12, P199, DOI 10.1901/jaba.1979.12-199
   Cooper J. O., 2007, APPL BEHAV ANAL
   Dvortcsak A., 2010, TEACHING SOCIAL COMM
   Greenspan S. I., 2006, INFANT EARLY CHILDHO
   Harmon R. J., 2000, J AM ACAD CHILD ADOL, V39, P1327
   Harrist AW, 2002, DEV REV, V22, P555, DOI 10.1016/S0273-2297(02)00500-2
   Hayes S. C., 1999, SCI PRACTITIONER RES
   Ingersoll B, 2011, J POSIT BEHAV INTERV, V13, P109, DOI 10.1177/1098300710384507
   Ingersoll BR, 2010, J POSIT BEHAV INTERV, V12, P33, DOI 10.1177/1098300709334797
   Koegel R. L., 1989, TEACH PIVOTAL BEHAV
   Kratochwill T. R., 2010, SINGLE CASE DESIGN T
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Mahoney G., 2007, AUTISM DEV DELAYS YO
   Mundy P., 2012, ED INTERVENTIONS STU, P107
   National Autism Center, 2009, NAT STAND REP
   National Professional Development Center on Autism Spectrum Disorders, 2011, NPDC ASD NAT STAND P
   National Professional Development Center on Autism Spectrum Disorders, 2011, NAT PROF DEV CTR AUT
   Odom S. L., 2010, PREVENTING SCH FAILU, V54, P275, DOI DOI 10.1080/10459881003785506
   Odom SL, 2010, J AUTISM DEV DISORD, V40, P425, DOI 10.1007/s10803-009-0825-1
   Parker RI, 2007, J SPEC EDUC, V40, P194, DOI 10.1177/00224669070400040101
   Rogers EM, 2003, DIFFUSION INNOVATION
   Rogers SJ, 2010, EARLY START DENVER M
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Salmon C. M., 1998, INFANT TODDLER INTER, V8, P11
   Schreibman L, 2000, J AUTISM DEV DISORD, V30, P373, DOI 10.1023/A:1005535120023
   Stahmer AC, 2011, BRAIN RES, V1380, P229, DOI 10.1016/j.brainres.2010.09.043
   Sussman F., 1999, MORE WORDS HELPING P
   WOLF M, 1964, BEHAV RES THER, V1, P305
   Yoder PJ, 1995, J EARLY INTERVENTION, V19, P218
NR 30
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2014
VL 29
IS 3
BP 168
EP 179
DI 10.1177/1088357613513792
PG 12
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AN4HA
UT WOS:000340547100004
ER

PT J
AU Wolfe, K
   Slocum, TA
   Kunnavatana, SS
AF Wolfe, Katie
   Slocum, Timothy A.
   Kunnavatana, S. Shanun
TI Promoting Behavioral Variability in Individuals With Autism Spectrum
   Disorders: A Literature Review
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; repetitive; response diversity; response variation; variability
ID RESPONSE VARIABILITY; CHILDREN; OPERANT; REINFORCEMENT; EXTINCTION;
   SCHEDULES; STUDENTS
AB Repetitive behavior is a hallmark feature of autism spectrum disorders (ASD), and can have adverse consequences related to social stigma and low rates of skill acquisition. Basic research suggests that variability, or the extent to which one response differs from previous responses, is amenable to antecedent and consequence manipulations. This article describes the concept of variability, synthesizes the findings of 14 recent studies on interventions to increase the variability of behavior in individuals with ASD, and proposes preliminary guidelines for practitioners that focus on building response repertoires, implementing contingencies to produce and maintain variability, and incorporating prompts to vary responding.
C1 [Wolfe, Katie] Univ S Carolina, Columbia, SC 29208 USA.
   [Slocum, Timothy A.; Kunnavatana, S. Shanun] Utah State Univ, Logan, UT 84322 USA.
RP Wolfe, K (reprint author), Univ S Carolina, Dept Educ Studies, 820 Main St,235-B Wardlaw, Columbia, SC 29208 USA.
EM kmsnyder@mailbox.sc.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   ANTONITIS JJ, 1951, J EXP PSYCHOL, V42, P273, DOI 10.1037/h0060407
   Argott P., 2010, THESIS CITY U NEW YO
   Bernstein H, 2008, RES AUTISM SPECT DIS, V2, P362, DOI 10.1016/j.rasd.2007.09.001
   Betz AM, 2011, J APPL BEHAV ANAL, V44, P357, DOI 10.1901/jaba.2011.44-357
   Bodfish JW, 2004, MENT RETARD DEV D R, V10, P318, DOI 10.1002/mrdd.20045
   Denney J, 1998, ANIM LEARN BEHAV, V26, P154, DOI 10.3758/BF03199208
   Esch John W, 2009, Anal Verbal Behav, V25, P73
   Koehler-Platten Kate, 2013, Anal Verbal Behav, V29, P71
   Harris SL, 2002, INFANT YOUNG CHILD, V14, P11
   Heldt Juliane, 2012, Anal Verbal Behav, V28, P131
   Lee R, 2007, PSYCHOL REC, V57, P429
   Lee R, 2006, J AUTISM DEV DISORD, V36, P421, DOI 10.1007/s10803-006-0080-7
   Lee R., 2007, THESIS CITY U NEW YO
   Lee R, 2002, J APPL BEHAV ANAL, V35, P391, DOI 10.1901/jaba.2002.35-391
   Leekam SR, 2011, PSYCHOL BULL, V137, P562, DOI 10.1037/a0023341
   Miller N, 2000, J APPL BEHAV ANAL, V33, P151, DOI 10.1901/jaba.2000.33-151
   Napolitano DA, 2010, J APPL BEHAV ANAL, V43, P265, DOI 10.1901/jaba.2010.43-265
   National Autism Center, 2009, NAT STAND REP
   Neuringer A, 2002, PSYCHON B REV, V9, P672, DOI 10.3758/BF03196324
   Newman B, 2000, BEHAV INTERVENT, V15, P145, DOI 10.1002/(SICI)1099-078X(200004/06)15:2<145::AID-BIN50>3.3.CO;2-V
   PAGE S, 1985, J EXP PSYCHOL ANIM B, V11, P429, DOI 10.1037//0097-7403.11.3.429
   Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
   SCHWARTZ B, 1982, J EXP ANAL BEHAV, V37, P171, DOI 10.1901/jeab.1982.37-171
   Sellers T. P., 2011, THESIS UTAH STATE U
   STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
   Susa Carrie, 2012, Anal Verbal Behav, V28, P125
   TATHAM TA, 1993, J EXP ANAL BEHAV, V59, P349, DOI 10.1901/jeab.1993.59-349
NR 28
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2014
VL 29
IS 3
BP 180
EP 190
DI 10.1177/1088357614525661
PG 11
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA AN4HA
UT WOS:000340547100005
ER

PT J
AU Song, C
   Zhang, HP
AF Song, Chi
   Zhang, Heping
TI TARV: Tree-based Analysis of Rare Variants Identifying Risk Modifying
   Variants in CTNNA2 and CNTNAP2 for Alcohol Addiction
SO GENETIC EPIDEMIOLOGY
LA English
DT Article
DE mutation; classification tree; association analysis; alcoholism
ID GENOME-WIDE ASSOCIATION; FUNCTIONAL LINEAR-MODELS; CLASSIFICATION TREES;
   COMMON DISEASES; AUTISM; DISORDERS; LINKAGE; TRAITS; GENES
AB Since the development of next generation sequencing (NGS) technology, researchers have been extending their efforts on genome-wide association studies (GWAS) from common variants to rare variants to find the missing inheritance. Although various statistical methods have been proposed to analyze rare variants data, they generally face difficulties for complex disease models involving multiple genes. In this paper, we propose a tree-based analysis of rare variants (TARV) that adopts a nonparametric disease model and is capable of exploring gene-gene interactions. We found that TARV outperforms the sequence kernel association test (SKAT) in most of our simulation scenarios, and by notable margins in some cases. By applying TARV to the study of addiction: genetics and environment (SAGE) data, we successfully detected gene CTNNA2 and its 43 specific variants that increase the risk of alcoholism in women, with an odds ratio (OR) of 1.94. This gene has not been detected in the SAGE data. Post hoc literature search also supports the role of CTNNA2 as a likely risk gene for alcohol addiction. In addition, we also detected a plausible protective gene CNTNAP2, whose 97 rare variants can reduce the risk of alcoholism in women, with an OR of 0.55. These findings suggest that TARV can be effective in dissecting genetic variants for complex diseases using rare variants data. (C) 2014 Wiley Periodicals, Inc.
C1 [Song, Chi; Zhang, Heping] Yale Univ, Sch Publ Hlth, Dept Biostat, New Haven, CT 06511 USA.
RP Zhang, HP (reprint author), Yale Univ, Sch Publ Hlth, Dept Biostat, 300 George St,Suite 523, New Haven, CT 06511 USA.
EM heping.zhang@yale.edu
FU National Institute on Drug Abuse [R01 DA016750]
FX This research is supported in part by grants R01 DA016750 from the
   National Institute on Drug Abuse. The dataset used for the analyses
   described in this manuscript was obtained from dbGaP at
   http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs0
   00092.v1.p1 through dbGaP accession number phs000092.v1.p.
CR Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
   Chen XP, 2011, ORGAN BEHAV HUM DEC, V114, P1, DOI 10.1016/j.obhdp.2010.11.001
   Fan RZ, 2013, GENET EPIDEMIOL, V37, P726, DOI 10.1002/gepi.21757
   Hindorff LA, 2009, P NATL ACAD SCI USA, V106, P9362, DOI 10.1073/pnas.0903103106
   Hoffmann TJ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013584
   Ji WD, 2013, PSYCHIAT RES, V207, P225, DOI 10.1016/j.psychres.2012.09.024
   Li BS, 2008, AM J HUM GENET, V83, P311, DOI 10.1016/j.ajhg.2008.06.024
   Loh WY, 2009, ANN APPL STAT, V3, P1710, DOI 10.1214/09-AOAS260
   Luo L, 2012, J MED GENET, V49, P513, DOI 10.1136/jmedgenet-2012-100798
   Luo L, 2011, GENOME RES, V21, P1099, DOI 10.1101/gr.115998.110
   Madsen BE, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000384
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Metzker ML, 2009, NAT REV GENET, V11, P31, DOI [10.1038/nrg2626, DOI 10.1038/NRG2626]
   Mexal S, 2008, AM J MED GENET B, V147B, P759, DOI 10.1002/ajmg.b.30679
   Morgenthaler S, 2007, MUTAT RES-FUND MOL M, V615, P28, DOI 10.1016/j.mrfmmm.2006.09.003
   Neale BM, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001322
   Olshen R., 1984, CLASSIFICATION REGRE, V1st
   Talluri R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069226
   Terracciano A, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.42
   Uhl GR, 2008, ANN NY ACAD SCI, V1141, P318, DOI 10.1196/annals.1441.018
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   WAGNER CH, 1982, AM STAT, V36, P46, DOI 10.2307/2684093
   Wu MC, 2011, AM J HUM GENET, V89, P82, DOI 10.1016/j.ajhg.2011.05.029
   Xu YJ, 2013, GENET EPIDEMIOL, V37, P163, DOI 10.1002/gepi.21696
   Zhang H, 2010, SPRINGER SER STAT, P1, DOI 10.1007/978-1-4419-6824-1
   Zhang HP, 2000, GENET EPIDEMIOL, V19, P323, DOI 10.1002/1098-2272(200012)19:4<323::AID-GEPI4>3.0.CO;2-5
   Zhang HP, 2001, GENET EPIDEMIOL, V21, pS317
NR 30
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0741-0395
EI 1098-2272
J9 GENET EPIDEMIOL
JI Genet. Epidemiol.
PD SEP
PY 2014
VL 38
IS 6
BP 552
EP 559
DI 10.1002/gepi.21843
PG 8
WC Genetics & Heredity; Public, Environmental & Occupational Health
SC Genetics & Heredity; Public, Environmental & Occupational Health
GA AN4KP
UT WOS:000340556900008
PM 25041903
ER

PT J
AU Fitzpatrick, EM
   Lambert, L
   Whittingham, J
   Leblanc, E
AF Fitzpatrick, Elizabeth M.
   Lambert, Linda
   Whittingham, JoAnne
   Leblanc, Emma
TI Examination of characteristics and management of children with hearing
   loss and autism spectrum disorders
SO INTERNATIONAL JOURNAL OF AUDIOLOGY
LA English
DT Article
DE Hearing loss; autism spectrum disorder; hearing aids; cochlear implants
ID COCHLEAR IMPLANTS; IMPAIRMENT; DIAGNOSIS; AGE; DEAFNESS; DISABILITIES;
   TODDLERS; OUTCOMES; REGIONS; CANADA
AB Objective: Up to 40% of children with hearing loss present with other developmental disabilities. The purpose of this study was to document the prevalence of autism spectrum disorders (ASD) in children with permanent hearing loss, to describe the audiologic characteristics, and to examine clinical management. Design: Prospective data related to clinical characteristics of children identified with hearing loss and ASD were examined. A retrospective chart review was also conducted to explore clinical management and uptake of amplification. Study sample: The study included all children in one Canadian region identified with permanent hearing loss and followed from 2002-2010. Results: Of a total of 785 children with permanent hearing loss, 2.2% (n = 17) also received a diagnosis of ASD. The 13 boys and 4 girls presented with a range of audiologic profiles from unilateral to profound bilateral hearing loss. Four of five children with unilateral hearing loss experienced progression to bilateral loss. Amplification was recommended for all but one child and 9 of 16 children continued to use their hearing devices. Conclusions: The higher prevalence rate of ASD in this clinical population is consistent with previous reports. Our findings suggest that some children with autism can derive benefits from the use of amplification.
C1 [Fitzpatrick, Elizabeth M.] Univ Ottawa, Fac Hlth Sci, Ottawa, ON K1H 8M5, Canada.
   [Fitzpatrick, Elizabeth M.; Whittingham, JoAnne] Childrens Hosp Eastern Ontario, Res Inst, Ottawa, ON K1H 8L1, Canada.
   [Lambert, Linda] Ctr Sante & Serv Sociaux Alphonse Desjardins, Levis, PQ, Canada.
   [Leblanc, Emma] Northwestern Univ, Dept Audiol, Chicago, IL 60611 USA.
RP Fitzpatrick, EM (reprint author), Univ Ottawa, Fac Hlth Sci, Ottawa, ON K1H 8M5, Canada.
EM elizabeth.fitzpatrick@uottawa.ca
FU Canadian Institutes of Health New Investigator Award; Canadian Child
   Health Clinician Scientist Program Award
FX This research was funded by a Canadian Institutes of Health New
   Investigator Award and a Canadian Child Health Clinician Scientist
   Program Award to the first author. We are grateful to the clinicians at
   the Children's Hospital of Eastern Ontario for their contributions of
   clinical data and for their collaboration throughout this study. We
   thank Viviane Grandpierre for assistance with updating the literature.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Berard G, 1993, HEARING EQUALS BEHAV
   Berkell D.E., 1996, EDUC TRAIN MENT RET, V3, P66
   Bishop DVM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015112
   Ceponiene R, 2003, P NATL ACAD SCI USA, V100, P5567, DOI 10.1073/pnas.0835631100
   Ching TYC, 2013, EAR HEARING, V34, P535, DOI 10.1097/AUD.0b013e3182857718
   Coo H, 2012, CHRON DIS INJ CAN, V32, P90
   Donaldson AI, 2004, ARCH OTOLARYNGOL, V130, P666, DOI 10.1001/archotol.130.5.666
   Edwards LC, 2007, J DEAF STUD DEAF EDU, V12, P258, DOI 10.1093/deafed/enm007
   Fitzpatrick EM, 2010, EAR HEARING, V31, P392, DOI 10.1097/AUD.0b013e3181cdb2b9
   Fitzpatrick E.M., 2013, PEDIAT AUDIOLOGIC RE
   Fitzpatrick E.M., 2013, EAR HEARING, V35, P10
   Fombonne Eric, 2010, Evid Based Ment Health, V13, P32, DOI 10.1136/ebmh.13.1.32
   Fortnum HM, 2001, BRIT MED J, V323, P536, DOI 10.1136/bmj.323.7312.536
   Gallaudet Research Institute, 2009, REG NAT SUMM REP DAT
   Gallaudet Research Institute, 2006, REG NAT SUMM REP DAT
   Gravel JS, 2006, EAR HEARING, V27, P299, DOI 10.1097/01.aud.0000215979.65645.22
   Guardino CA, 2008, AM ANN DEAF, V153, P55
   Hyman SL, 2013, AAP NEWS
   JURE R, 1991, DEV MED CHILD NEUROL, V33, P1062
   Kennedy CR, 2006, NEW ENGL J MED, V354, P2131, DOI 10.1056/NEJMoa054915
   Kozlowski AM, 2011, DEV NEUROREHABIL, V14, P72, DOI 10.3109/17518423.2010.539193
   Lantz J., 2003, REPORTER, V8, P11
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MacKay S., 2008, TRENDS AMPLIF, V12, P43
   Ministry of Children and Youth Services, 2013, AUT SERV SUPP CHILDR
   Myck-Wayne J, 2011, AM ANN DEAF, V156, P379
   Ouellette-Kuntz H, 2012, CHRON DIS INJ CAN, V32, P84
   Ouellette-Kuntz HMJ, 2009, CAN J PUBLIC HEALTH, V100, P268
   Ozonoff S., 2011, PEDIATRICS, V128, pe1
   Picard M, 2004, VOLTA REV, V104, P221
   Porter H., 2011, COMPREHENSIVE HDB PE, P175
   Prieve BA, 2000, EAR HEARING, V21, P85, DOI 10.1097/00003446-200004000-00003
   Rimland B., 1994, AM J SPEECH-LANG PAT, V3, P16
   Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
   Roper L, 2003, AUTISM, V7, P245, DOI 10.1177/1362361303007003002
   Rosenhall U, 1999, J AUTISM DEV DISORD, V29, P349, DOI 10.1023/A:1023022709710
   Stiegler LN, 2010, FOCUS AUTISM DEV DIS, V25, P67, DOI 10.1177/1088357610364530
   Szymanski C., 2008, ODYSSEY NEW DIRECTIO, V9, P10
   Szymanski CA, 2012, J AUTISM DEV DISORD, V42, P2027, DOI 10.1007/s10803-012-1452-9
   Tharpe A M, 2001, Am J Audiol, V10, P32
   Tharpe AM, 2006, EAR HEARING, V27, P430, DOI 10.1097/01.aud.0000224981.60575.d8
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Vernon M, 2009, AM ANN DEAF, V154, P5
   Wake M, 2005, ARCH DIS CHILD, V90, P238, DOI 10.1136/adc.2003.039354
   Worley JA, 2011, DEV NEUROREHABIL, V14, P171, DOI 10.3109/17518423.2011.564600
NR 46
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1499-2027
EI 1708-8186
J9 INT J AUDIOL
JI Int. J. Audiol.
PD SEP
PY 2014
VL 53
IS 9
BP 577
EP 586
DI 10.3109/14992027.2014.903338
PG 10
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA AN3AM
UT WOS:000340457200001
PM 24832530
ER

PT J
AU Fredo, ARJ
   Kavitha, G
   Ramakrishnan, S
AF Fredo, A. R. Jac
   Kavitha, G.
   Ramakrishnan, S.
TI Segmentation and Analysis of Brain Subcortical Regions Using Regularized
   Multiphase Level Set in Autistic MRImages
SO INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
LA English
DT Article
DE autism; subcortical regions; multiphase level set; fuzzy c-means
   cluster; intelligent quotient values
ID IMAGE SEGMENTATION; ACTIVE CONTOURS; CHILDREN; MRI; VOLUMES; MODEL
AB In this work, subcortical regions of autistic magnetic resonance brain images are analyzed using multiphase level set method. The images considered in this work are obtained from autism brain image data exchange database. The subcortical regions such as corpus callosum, cerebellum, and brain stem are segmented from the cortical region using Fuzzy c-means (FCM)-based multiphase level set method. FCM with three cluster center is used as the intensity discriminator and the evolution of the level set curve is regularized by a distance function. The results show that the multiphase level set method is able to segment the desired subcortical regions. The results are validated with the ground truth images. The average similarity values are found to be 0.85. The segmented subcortical regions of autistic have reduced tissue area and are distinct from the controls (p<0.0001). Further, it is observed that the subcortical area gives comparable results with clinical intelligent quotient values and is able to discriminate the controls and autistic subjects. As the feature area extracted from brain subcortical regions are significant, this study seems to be clinically helpful in mass screening of autistic subjects. (C) 2014 Wiley Periodicals, Inc.
C1 [Fredo, A. R. Jac; Kavitha, G.] Anna Univ, Dept Elect Engn, Madras 600025, Tamil Nadu, India.
   [Ramakrishnan, S.] Indian Inst Technol Madras, Dept Appl Mech, Biomed Engn Grp, Noninvas Imaging & Diagnost Lab, Madras, Tamil Nadu, India.
RP Fredo, ARJ (reprint author), Anna Univ, Dept Elect Engn, MIT Campus, Madras 600025, Tamil Nadu, India.
EM jack247029@gmail.com
FU University Grant Commission under the scheme Maulana Azad National
   Fellowship for Minority students [F1-17.1/2011/MANF-CHRTAM-1826]
FX Grant sponsors: The first author Jac Fredo A. R. is receiving fellowship
   from University Grant Commission under the scheme Maulana Azad National
   Fellowship for Minority students (F1-17.1/2011/MANF-CHRTAM-1826) for his
   research work.
CR American Psychiatric Association, 2001, DIAGN STAT MAN MENT, V4th
   Angelini ED, 2004, P SOC PHOTO-OPT INS, V5370, P526, DOI 10.1117/12.535860
   Angelini Elsa D, 2007, Int J Biomed Imaging, V2007, P10526, DOI 10.1155/2007/10526
   Bhadauria H.S., 2013, COMPUT ELECTR ENG, V39, P527
   Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
   Caselles V, 1997, INT J COMPUT VISION, V22, P61, DOI 10.1023/A:1007979827043
   Chan TF, 2001, IEEE T IMAGE PROCESS, V10, P266, DOI 10.1109/83.902291
   Choi S.S., 2010, J SYSTEMICS CYBERNET, V8, P43
   Clendenen TV, 2013, J MAGN RESON IMAGING, V38, P474, DOI 10.1002/jmri.24002
   Di Martino A, 2014, MOL PSYCHIATR, V19, P659, DOI 10.1038/mp.2013.78
   Dirami A, 2013, SIGNAL PROCESS, V93, P139, DOI 10.1016/j.sigpro.2012.07.010
   Elsayed E., 2010, KNOWL-BASED SYST, V23, P330
   Fahim C, 2012, RES AUTISM SPECT DIS, V6, P898, DOI 10.1016/j.rasd.2011.11.008
   Hardan AY, 2009, PSYCHIAT RES-NEUROIM, V174, P57, DOI 10.1016/j.pscychresns.2009.03.005
   He L, 2010, J VIS COMMUN IMAGE R, V21, P343, DOI 10.1016/j.jvcir.2010.02.009
   Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
   Hsu CY, 2010, EURASIP J ADV SIG PR, DOI 10.1155/2010/950438
   Icer S, 2013, COMPUT METH PROG BIO, V112, P38, DOI 10.1016/j.cmpb.2013.06.006
   Jamshidi O., 2013, J COMPUT MED, V2013, P1
   Jou RJ, 2013, BEHAV BRAIN RES, V251, P163, DOI 10.1016/j.bbr.2013.04.021
   Jou RJ, 2009, PSYCHOL MED, V39, P1347, DOI 10.1017/S0033291708004376
   Li CM, 2011, IEEE T IMAGE PROCESS, V20, P2007, DOI 10.1109/TIP.2011.2146190
   Pitiot A., 2004, NEUROIMAGE, V23, P85
   Prigge MBD, 2013, RES AUTISM SPECT DIS, V7, P221, DOI 10.1016/j.rasd.2012.09.007
   Priya RK, 2013, INT J IMAG SYST TECH, V23, P281, DOI 10.1002/ima.22062
   Sabuncu MR, 2010, IEEE T MED IMAGING, V29, P1714, DOI 10.1109/TMI.2010.2050897
   Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076
   Suganthi M, 2012, J MED SYST, V36, P79, DOI 10.1007/s10916-010-9448-5
   Timothy J.H., 2012, FRONT NEUROINFORM, V6, P1
   Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001
   Zhang KH, 2010, IEEE IMAGE PROC, P4105, DOI 10.1109/ICIP.2010.5651554
NR 31
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0899-9457
EI 1098-1098
J9 INT J IMAG SYST TECH
JI Int. J. Imaging Syst. Technol.
PD SEP
PY 2014
VL 24
IS 3
BP 256
EP 262
DI 10.1002/ima.22101
PG 7
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
   Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA AN3NI
UT WOS:000340494700007
ER

PT J
AU Goddard, L
   Dritschel, B
   Howlin, P
AF Goddard, Lorna
   Dritschel, Barbara
   Howlin, Patricia
TI A Preliminary Study of Gender Differences in Autobiographical Memory in
   Children with an Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autobiographical memory; Gender; Autism spectrum disorder
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; EPISODIC MEMORY;
   SEX-DIFFERENCES; ADULTS; SELF; DEPRESSION; RETRIEVAL; CONSTRUCTION;
   INDIVIDUALS
AB Autobiographical memory was assessed in 24 children (12 male, 12 female, aged between 8 and 16 years) with autism spectrum disorder (ASD) and a comparison group of 24 typically developing (TD) children matched for age, IQ, gender and receptive language. Results suggested that a deficit in specific memory retrieval in the ASD group was more characteristic of male participants. Females in both the TD and ASD groups generated more detailed and emotional memories than males. They also demonstrated superior verbal fluency scores; verbal fluency and autobiographical memory cueing task performance were significantly positively correlated in females. Results are discussed in light of recent research suggesting gender differences in the phenotype of ASD.
C1 [Goddard, Lorna] Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England.
   [Dritschel, Barbara] Univ St Andrews, Dept Psychol, St Andrews KY16 9AJ, Fife, Scotland.
   [Howlin, Patricia] Kings Coll London, Inst Psychiat, London SE5 8AF, England.
RP Goddard, L (reprint author), Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England.
EM l.goddard@gold.ac.uk
CR Andreano JM, 2009, LEARN MEMORY, V16, P248, DOI 10.1101/lm.918309
   Attwood T., 2007, COMPLETE GUIDE ASPER
   Barnett MP, 2000, MEMORY, V8, P413
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Bolte S, 2011, AUTISM, V15, P497, DOI 10.1177/1362361310391116
   Bowler DM, 2000, J AUTISM DEV DISORD, V30, P295, DOI 10.1023/A:1005575216176
   Brown BT, 2012, J AUTISM DEV DISORD, V42, P441, DOI 10.1007/s10803-011-1246-5
   Bruck M, 2007, DEV PSYCHOPATHOL, V19, P73, DOI 10.1017/S0954579407070058
   Buckner JP, 2000, MEMORY, V8, P401
   Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
   COLTHEART M, 1981, Q J EXP PSYCHOL-A, V33, P497
   Conway MA, 2000, PSYCHOL REV, V107, P261, DOI 10.1037//0033-295X.107.2.261
   Crane L, 2009, MEMORY, V17, P557, DOI 10.1080/09658210902960211
   Crane L, 2013, AUTISM, V17, P205, DOI 10.1177/1362361311418690
   Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
   Crane L, 2010, J AUTISM DEV DISORD, V40, P383, DOI 10.1007/s10803-009-0875-4
   CROVITZ HF, 1974, B PSYCHONOMIC SOC, V4, P517
   Dalgleish T, 2007, J EXP PSYCHOL GEN, V136, P23, DOI 10.1037/0096-3445.136.1.23
   Davis PJ, 1999, J PERS SOC PSYCHOL, V76, P498, DOI 10.1037/0022-3514.76.3.498
   Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
   Dworzynski K, 2012, J AM ACAD CHILD PSY, V51, P788, DOI 10.1016/j.jaac.2012.05.018
   Farrant K, 2000, J COGN DEV, V1, P193, DOI 10.1207/S15327647JCD010203
   Goddard L, 2014, DEV PSYCHOPATHOL, V26, P215, DOI 10.1017/S0954579413000904
   Goddard L, 2001, BRIT J CLIN PSYCHOL, V40, P297, DOI 10.1348/014466501163706
   Goddard L, 1996, J ABNORM PSYCHOL, V105, P609, DOI 10.1037/0021-843X.105.4.609
   Goddard L, 2007, J AUTISM DEV DISORD, V37, P291, DOI 10.1007/s10803-006-0168-0
   Goddard L, 1998, BRIT J PSYCHOL, V89, P611
   Gould J., 2011, GOOD AUTISM PRACTICE, V12, P34
   Greene JDW, 1995, NEUROPSYCHOLOGIA, V33, P1647, DOI 10.1016/0028-3932(95)00046-1
   Haden CA, 1997, DEV PSYCHOL, V33, P295, DOI 10.1037/0012-1649.33.2.295
   Jacques PLS, 2011, MEMORY, V19, P723, DOI 10.1080/09658211.2010.516266
   Jordan R., 1993, EDUC PSYCHOL, V13, P359, DOI 10.1080/0144341930130312
   Knickmeyer RC, 2008, J AUTISM DEV DISORD, V38, P1028, DOI 10.1007/s10803-007-0475-0
   Kothari R, 2013, J AM ACAD CHILD PSY, V52, P1148, DOI 10.1016/j.jaac.2013.08.006
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   Lai MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047198
   Levine B, 2004, BRAIN COGNITION, V55, P54, DOI 10.1016/s0278-2626(03)00280-x
   Lind SE, 2010, AUTISM, V14, P430, DOI 10.1177/1362361309358700
   Lind SE, 2014, NEUROPSYCHOLOGY, V28, P55, DOI 10.1037/neu0000005
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
   MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   NELSON K, 1993, PSYCHOL SCI, V4, P7, DOI 10.1111/j.1467-9280.1993.tb00548.x
   Neshat-Doost H. T., 2013, CLIN PSYCHOL SCI, V1, P84, DOI [10.1177/2167702612454613, DOI 10.1177/2167702612454613]
   Pillemer DB, 2003, MEMORY, V11, P525, DOI 10.1080/09658210244000117
   Raes F, 2009, J BEHAV THER EXP PSY, V40, P24, DOI 10.1016/j.jbtep.2008.03.001
   Rivet TT, 2011, RES AUTISM SPECT DIS, V5, P957, DOI 10.1016/j.rasd.2010.12.003
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schlagman S, 2008, MEM COGNITION, V36, P920, DOI 10.3758/MC.36.5.920
   Wechsler D, 1999, WECHSLER ABBREVIATED
NR 53
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2087
EP 2095
DI 10.1007/s10803-014-2109-7
PG 9
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400001
PM 24777286
ER

PT J
AU Camargo, SPH
   Rispoli, M
   Ganz, J
   Hong, ER
   Davis, H
   Mason, R
AF Hoeher Camargo, Siglia Pimentel
   Rispoli, Mandy
   Ganz, Jennifer
   Hong, Ee Rea
   Davis, Heather
   Mason, Rose
TI A Review of the Quality of Behaviorally-Based Intervention Research to
   Improve Social Interaction Skills of Children with ASD in Inclusive
   Settings
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Social skills; Behavioral interventions; Inclusive education;
   Single-case research; Quality analysis
ID AUTISM SPECTRUM DISORDERS; SINGLE-SUBJECT RESEARCH; SCRIPT-FADING
   PROCEDURE; SPECIAL-EDUCATION; DEVELOPMENTAL-DISABILITIES;
   YOUNG-CHILDREN; SCHOOL SETTINGS; COMMUNICATION INTERVENTIONS;
   LEARNING-DISABILITIES; STUDENTS
AB Students with autism spectrum disorders (ASDs) often have difficulties in social interaction skills, which may prevent their successful inclusion in general education placements. Behaviorally-based social skills interventions have been shown to be effective in attenuating such difficulties in these environments. In light of the increasing number of children with ASD being educated in inclusive settings and requirements for the use of research-based interventions in schools, this paper (1) analyzes the quality of single-case research using behaviorally-based interventions to improve social interaction skills of children with ASD in inclusive settings and (2) evaluates whether such interventions can be considered an evidence-based practice. Characteristics and components of the interventions are summarized, and their implications for practice and future research are discussed.
C1 [Hoeher Camargo, Siglia Pimentel; Rispoli, Mandy; Ganz, Jennifer; Hong, Ee Rea; Davis, Heather; Mason, Rose] Texas A&M Univ, Dept Educ Psychol, College Stn, TX 77843 USA.
RP Camargo, SPH (reprint author), Univ Fed Pelotas, Fac Educ, Rua Alberto Rosa 154, BR-96010770 Pelotas, RS, Brazil.
EM sigliahoher@yahoo.com.br; mrispoli@tamu.edu; jeniganz@tamu.edu;
   ghdeerea@neo.tamu.edu; heatherstepdavis@gmail.com;
   rosemason519@gmail.com
CR Anderson A, 2004, AUTISM, V8, P369, DOI 10.1177/1362361304045216
   Apple AL, 2005, J POSIT BEHAV INTERV, V7, P33, DOI 10.1177/10983007050070010401
   BAER DM, 1968, J APPL BEHAV ANAL, V1, P91, DOI 10.1901/jaba.1968.1-91
   Baker J., 2001, SOCIAL SKILLS PICTUR
   Banda DR, 2010, RES AUTISM SPECT DIS, V4, P619, DOI 10.1016/j.rasd.2009.12.005
   Baron-Cohen Simon, 2004, Pediatr Rehabil, V7, P73, DOI 10.1080/13638490310001654790
   Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
   Bellini S, 2007, EXCEPT CHILDREN, V73, P264
   Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
   Ben-Itzchak E, 2007, RES DEV DISABIL, V28, P287, DOI 10.1016/j.ridd.2006.03.002
   Boardman AG, 2005, J SPEC EDUC, V39, P168, DOI 10.1177/00224669050390030401
   Boyd BA, 2008, EDUC TRAIN DEV DISAB, V43, P186
   Chan JM, 2008, J APPL BEHAV ANAL, V41, P405, DOI 10.1901/jaba.2008.41-405
   Chard DJ, 2009, EXCEPT CHILDREN, V75, P263
   Charlop-Christy M.H., 2003, EDUC TREAT CHILD, V26, P108
   Clark DM, 1999, INTERV SCH CLIN, V34, P248, DOI 10.1177/105345129903400413
   Cook BG, 2009, EXCEPT CHILDREN, V75, P365
   Crozier S, 2007, J AUTISM DEV DISORD, V37, P1803, DOI 10.1007/s10803-006-0315-7
   Kohler F W, 1995, Behav Modif, V19, P10, DOI 10.1177/01454455950191002
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Ganz JB, 2008, J AUTISM DEV DISORD, V38, P926, DOI 10.1007/s10803-007-0463-4
   Garfinkle AN, 2002, TOP EARLY CHILD SPEC, V22, P26, DOI 10.1177/027112140202200103
   Garrison-Harrell L., 1997, FOCUS AUTISM OTHER D, V12, P241, DOI DOI 10.1177/108835769701200406
   Gena A, 2006, INT J PSYCHOL, V41, P541, DOI 10.1080/00207590500492658
   Gersten R, 2005, EXCEPT CHILDREN, V71, P149
   Gillis J. M., 2007, J EARLY INTENSIVE BE, V4, P532
   Hunt P, 1997, J SPEC EDUC, V31, P3
   GOLDSTEIN H, 1992, J APPL BEHAV ANAL, V25, P289, DOI 10.1901/jaba.1992.25-289
   Greenway C., 2000, ED PSYCHOL PRACTICE, V16, P469, DOI 10.1080/713666112
   Gresham F. M., 2000, LEARNING DISABILITIE, V15, P198, DOI DOI 10.1207/SLDRP1504_4
   Gresham FM, 2001, EXCEPT CHILDREN, V67, P331
   Gutierrez Jr A, 2007, INT J SPECIAL ED, V22, P26
   Harper CB, 2008, J AUTISM DEV DISORD, V38, P815, DOI 10.1007/s10803-007-0449-2
   Harrower J. K., 1999, J POSIT BEHAV INTERV, V1, P215, DOI 10.1177/109830079900100404
   Harrower JK, 2001, BEHAV MODIF, V25, P762, DOI 10.1177/0145445501255006
   Hart JE, 2008, INTERV SCH CLIN, V44, P116, DOI 10.1177/1053451207310346
   Heflin L., 2007, STUDENTS AUTISM SPEC, V2nd
   Horner RH, 2005, EXCEPT CHILDREN, V71, P165
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Hughes C, 2011, RES PRACT PERS SEV D, V36, P46
   Janzen J. E., 2003, UNDERSTANDING NATURE
   Jitendra AK, 2011, EXCEPT CHILDREN, V77, P135
   Jung S, 2008, J EARLY INTERVENTION, V30, P163, DOI 10.1177/1053815108317970
   Kamps D., 1997, J BEHAV ED, V7, P335, DOI 10.1023/A:1022879607019
   KAMPS DM, 1992, J APPL BEHAV ANAL, V25, P281, DOI 10.1901/jaba.1992.25-281
   Karagiannis A., 1996, INCLUSION GUIDE ED
   Kavale KA, 2000, REM SPEC EDUC, V21, P279, DOI 10.1177/074193250002100505
   Kern Petra, 2006, J Music Ther, V43, P270
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Koegel L, 2012, COGN BEHAV PRACT, V19, P401
   Koegel LK, 2012, BEHAV MODIF, V36, P361, DOI 10.1177/0145445512445609
   Kohler FW, 2001, TOP EARLY CHILD SPEC, V21, P93, DOI 10.1177/027112140102100203
   Kohler FW, 2007, TOP EARLY CHILD SPEC, V27, P155, DOI 10.1177/02711214070270030601
   Krantz PJ, 1998, J APPL BEHAV ANAL, V31, P191, DOI 10.1901/jaba.1998.31-191
   KRANTZ PJ, 1993, J APPL BEHAV ANAL, V26, P121, DOI 10.1901/jaba.1993.26-121
   Kratochwill T. R., 2010, SINGLE CASE DESIGNS
   Kratochwill TR, 2010, PSYCHOL METHODS, V15, P124, DOI 10.1037/a0017736
   Laushey KM, 2000, J AUTISM DEV DISORD, V30, P183, DOI 10.1023/A:1005558101038
   Leach D., 2010, BRINGING ABA YOUR IN
   Lerman DC, 2004, SCHOOL PSYCHOL REV, V33, P510
   Loftin RL, 2008, J AUTISM DEV DISORD, V38, P1124, DOI 10.1007/s10803-007-0499-5
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Mason RA, 2012, RES DEV DISABIL, V33, P1076, DOI 10.1016/j.ridd.2012.01.016
   Matson JL, 2007, BEHAV MODIF, V31, P682, DOI 10.1177/0145445507301650
   Mayton MR, 2010, EDUC TRAIN AUTISM DE, V45, P539
   MCGEE GG, 1992, J APPL BEHAV ANAL, V25, P117, DOI 10.1901/jaba.1992.25-117
   Mcgee GG, 2007, RES PRACT PERS SEV D, V32, P112
   McGrath AM, 2003, J POSIT BEHAV INTERV, V5, P47, DOI 10.1177/10983007030050010701
   Mesibov GB, 1996, J AUTISM DEV DISORD, V26, P337, DOI 10.1007/BF02172478
   Millar DC, 2006, J SPEECH LANG HEAR R, V49, P248, DOI 10.1044/1092-4388(2006/021)
   Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
   Nelson C, 2007, EDUC TRAIN DEV DISAB, V42, P165
   Odom SL, 2005, EXCEPT CHILDREN, V71, P137
   ODOM SL, 1990, TOP EARLY CHILD SPEC, V10, P48
   Owen-DeSchryver JS, 2008, FOCUS AUTISM DEV DIS, V23, P15, DOI 10.1177/1088357608314370
   PIERCE K, 1995, J APPL BEHAV ANAL, V28, P285, DOI 10.1901/jaba.1995.28-285
   Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149
   Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
   Reichow B, 2008, J AUTISM DEV DISORD, V38, P1311, DOI 10.1007/s10803-007-0517-7
   Ricciardi J. N., 2005, EDUC TREAT CHILD, V28, P1
   Rispoli MJ, 2010, DEV NEUROREHABIL, V13, P276, DOI 10.3109/17518421003636794
   Rogers J., 1993, RES B PHI DELTA KAPP, V11, P1
   Romanczyk R., 2005, J EARLY INTENSIVE BE, V2, P177
   Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
   SAINATO DM, 1992, J APPL BEHAV ANAL, V25, P127, DOI 10.1901/jaba.1992.25-127
   Sansosti FJ, 2008, J POSIT BEHAV INTERV, V10, P162, DOI 10.1177/1098300708316259
   Scattone D, 2007, PSYCHOL SCHOOLS, V44, P717, DOI 10.1002/pits.20260
   Schlosser RW, 2006, RES DEV DISABIL, V27, P1, DOI 10.1016/j.ridd.2004.04.004
   Scruggs TE, 1998, BEHAV MODIF, V22, P221, DOI 10.1177/01454455980223001
   Shabani DB, 2002, J APPL BEHAV ANAL, V35, P79, DOI 10.1901/jaba.2002.35-79
   Shearer D. D., 1996, EARLY EDUC DEV, V7, P205, DOI 10.1027/s15566935eed0703_1
   Shearer D. D., 1996, POSITIVE BEHAV SUPPO
   Simpson A, 2004, EDUC TRAIN DEV DISAB, V39, P240
   Smith S., 2007, EDUC TREAT CHILD, V30, P121, DOI 10.1353/etc.2007.0033
   Stahmer AC, 2009, PSYCHOL SERV, V6, P223, DOI 10.1037/a0010738
   Strain P. S., 2001, FOCUS AUTISM OTHER D, V16, P120, DOI DOI 10.1177/108835760101600208
   Tankersley M., 2008, ED TREATMENT CHILDRE, V31, P523
   Tantam D., 2000, AUTISM INT J RES PRA, V4, P47, DOI DOI 10.1177/1362361300004001004
   Thiemann KS, 2004, J SPEECH LANG HEAR R, V47, P126, DOI 10.1044/1092-4388(2004/012)
   Vaughn S, 2003, REM SPEC EDUC, V24, P2, DOI 10.1177/074193250302400101
   Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
   Wang SY, 2011, RES AUTISM SPECT DIS, V5, P562, DOI 10.1016/j.rasd.2010.06.023
   Welsh M, 2001, J SCHOOL PSYCHOL, V39, P463, DOI 10.1016/S0022-4405(01)00084-X
   White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
   Yell M. L., 1996, PREVENTING SCH FAILU, V40, P101
   Yell M. L., 2006, LAW SPECIAL ED
   Zanolli K, 1996, J AUTISM DEV DISORD, V26, P407, DOI 10.1007/BF02172826
NR 107
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2096
EP 2116
DI 10.1007/s10803-014-2060-7
PG 21
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400002
PM 24781498
ER

PT J
AU Joshi, G
   Faraone, SV
   Wozniak, J
   Petty, C
   Fried, R
   Galdo, M
   Furtak, SL
   McDermott, K
   Epstien, C
   Walker, R
   Caron, A
   Feinberg, L
   Biederman, J
AF Joshi, Gagan
   Faraone, Stephen V.
   Wozniak, Janet
   Petty, Carter
   Fried, Ronna
   Galdo, Maribel
   Furtak, Stephannie L.
   McDermott, Katie
   Epstien, Cecily
   Walker, Rosemary
   Caron, Ashley
   Feinberg, Leah
   Biederman, Joseph
TI Examining the Clinical Correlates of Autism Spectrum Disorder in Youth
   by Ascertainment Source
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Psychiatric comorbidity; Youth
ID PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT HYPERACTIVITY DISORDER;
   ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ASPERGER-SYNDROME; PSYCHIATRIC
   COMORBIDITY; REFERRED POPULATION; GLOBAL ASSESSMENT; BIPOLAR DISORDER;
   ANXIETY SYMPTOMS; YOUNG-ADULTS
AB To examine whether presentation of autism spectrum disorder (ASD) and associated patterns of psychiatric comorbidity and dysfunction vary by referral source. ASD youth referred to a specialized ambulatory program for ASD (N = 143) were compared to ASD youth referred to a general child psychiatry clinic (N = 217). More ASD clinic youth met criteria for a more robust form of ASD (autistic disorder); more youth referred to the psychiatry clinic met criteria for broader spectrum ASD (pervasive developmental disorder not otherwise specified). General psychiatry clinic youth with ASD suffered from a greater burden of psychopathologies and higher levels of dysfunction. The presentation of ASD in psychiatrically referred youth differs between general and ASD-specialized clinics, though both referral populations have high levels of comorbidity and dysfunction.
C1 [Joshi, Gagan; Wozniak, Janet; Petty, Carter; Fried, Ronna; Galdo, Maribel; Furtak, Stephannie L.; McDermott, Katie; Epstien, Cecily; Walker, Rosemary; Caron, Ashley; Feinberg, Leah; Biederman, Joseph] Massachusetts Gen Hosp, Clin & Res Program Pediat Psychopharmacol, Boston, MA 02114 USA.
   [Joshi, Gagan; Wozniak, Janet; Fried, Ronna; Biederman, Joseph] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
   [Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA.
RP Joshi, G (reprint author), Massachusetts Gen Hosp, Clin & Res Program Pediat Psychopharmacol, 55 Fruit St,YAW 6A, Boston, MA 02114 USA.
EM joshi.gagan@mgh.harvard.edu
CR American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Biederman J, 1997, J AM ACAD CHILD PSY, V36, P1682, DOI 10.1097/00004583-199712000-00016
   Biederman J, 2006, PSYCHOL MED, V36, P167, DOI 10.1017/S0033291705006410
   Blumberg SJ, 2013, NATL CTR HLTH STAT, V2013, P65
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   ENDICOTT J, 1976, ARCH GEN PSYCHIAT, V33, P766
   Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
   Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
   Gallagher L., 2012, J INTELL DISABIL RES, V56, P248, DOI [10.1111/j.1365-2788.2011.01423.x, DOI 10.1111/J.1365-2788.2011.01423.X]
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
   Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7
   Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
   Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
   Guttmann-Steinmetz S, 2009, J AUTISM DEV DISORD, V39, P976, DOI 10.1007/s10803-009-0706-7
   Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA
   HOLM S, 1979, SCAND J STAT, V6, P65
   Joshi G, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-204
   Joshi G, 2013, J CLIN PSYCHIAT, V74, P578, DOI 10.4088/JCP.12m07392
   Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9
   Kurita H, 2004, J DEV PHYS DISABIL, V16, P377, DOI 10.1007/s10882-004-0693-8
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Lecavalier L, 2011, AUTISM, V15, P527, DOI 10.1177/1362361310391115
   Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
   Levy SE, 2010, J DEV BEHAV PEDIATR, V31, P267, DOI 10.1097/DBP.0b013e3181d5d03b
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Mazefsky CA, 2012, J CLIN CHILD ADOLESC, V41, P516, DOI 10.1080/15374416.2012.686102
   Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
   Oliver P, 2003, BRIT J PSYCHIAT, V182, pS32, DOI 10.1192/bjp.182.44.s32
   Orvaschel H., 1987, SCHEDULE AFFECTIVE D
   Orvaschel H., 1994, SCHEDULE AFFECTIVE D
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
   Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
   Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
   Sikora Darryn M, 2012, Pediatrics, V130 Suppl 2, pS91, DOI 10.1542/peds.2012-0900G
   Sterling L, 2008, J AUTISM DEV DISORD, V38, P1011, DOI 10.1007/s10803-007-0477-y
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   SVERD J, 1995, CHILD PSYCHIAT HUM D, V25, P221
   Sverd JR, 2003, PSYCHIAT SERV, V54, P1519, DOI 10.1176/appi.ps.54.11.1519
   SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
   van Steensel FJA, 2013, J CHILD FAM STUD, V22, P368, DOI 10.1007/s10826-012-9587-z
   Vickerstaff S, 2007, J AUTISM DEV DISORD, V37, P1647, DOI 10.1007/s10803-006-0292-x
   Wechsler D., 1991, MANUAL WECHSLER INTE
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477
   Weissman AS, 2010, RES AUTISM SPECT DIS, V4, P670, DOI 10.1016/j.rasd.2010.01.005
   White SW, 2012, AUTISM, V16, P453, DOI 10.1177/1362361311431951
   WING L, 1981, PSYCHOL MED, V11, P115
   Wozniak J, 1997, J AM ACAD CHILD PSY, V36, P1552, DOI 10.1016/S0890-8567(09)66564-3
   Wozniak J, 2007, EUR NEUROPSYCHOPHARM, V17, P440, DOI 10.1016/j.euroneuro.2006.11.006
   Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1
   Zafar S., 2008, CLIN NEUROPSYCHIATRY, V5, P9
NR 54
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2117
EP 2126
DI 10.1007/s10803-014-2063-4
PG 10
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400003
PM 24566937
ER

PT J
AU Sun, X
   Allison, C
   Auyeung, B
   Matthews, FE
   Sharp, SJ
   Baron-Cohen, S
   Brayne, C
AF Sun, Xiang
   Allison, Carrie
   Auyeung, Bonnie
   Matthews, Fiona E.
   Sharp, Stephen J.
   Baron-Cohen, Simon
   Brayne, Carol
TI The Mandarin Childhood Autism Spectrum Test (CAST): Sex Differences
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Social behaviours; Communication; Sex differences; China
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS;
   ASPERGER-SYNDROME; CHILDREN; QUOTIENT; PREVALENCE; ADULTS; POPULATION;
   UK; PSYCHOPATHOLOGY
AB Sex differences in social and communication behaviours related to autism spectrum conditions (ASC) have been investigated mainly in Western populations. Little research has been done in Chinese populations. This study explored sex differences related to ASC characteristics by examining differences in item responses and score distributions in relation to a screening instrument, the Childhood Autism Spectrum Test (CAST), used with Chinese children. A Mandarin Chinese version of the CAST (M-CAST) was distributed to 737 children aged 6-11 years in mainstream schools in Beijing. Questionnaires from 682 (93 %) children were available for analysis. The median score for boys was higher than for girls [boys, median = 8 (IQR 6, 11); girls, median = 7 (IQR 4, 9); p < 0.001]. There were differences in the proportions of boys and girls across all three score groups (a parts per thousand currency sign11, 12-14, a parts per thousand yen15) with more boys being found in the higher score groups (p = 0.035). This finding provides evidence that boys and girls have different social and communication development profiles, consistent with previous findings in Western cultures. These results suggest that sex differences related to ASC are consistent across cultures.
C1 [Sun, Xiang; Brayne, Carol] Univ Cambridge, Sch Clin Med, Cambridge Inst Publ Hlth, Cambridge CB2 0SR, England.
   [Sun, Xiang; Allison, Carrie; Auyeung, Bonnie; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England.
   [Sun, Xiang] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
   [Auyeung, Bonnie] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
   [Matthews, Fiona E.] Univ Cambridge, MRC Biostat Unit, Cambridge Inst Publ Hlth, Cambridge CB2 0SR, England.
   [Sharp, Stephen J.] Univ Cambridge, MRC Epidemiol Unit, Addenbrookes Hosp, Inst Metab Sci, Cambridge CB2 0QQ, England.
RP Sun, X (reprint author), Univ Cambridge, Sch Clin Med, Cambridge Inst Publ Hlth, Forvie Site,Cambridge Biomed Campus, Cambridge CB2 0SR, England.
EM xs227@medschl.cam.ac.uk
CR Allison C., 2013, BRAYNE C
   American Psychiatric Association, 2000, DSM4TR AM PSYCH ASS
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Baron-Cohen S, 2003, J AUTISM DEV DISORD, V33, P509, DOI 10.1023/A:1025879411971
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
   Bernier R, 2010, CHILD ADOL PSYCH CL, V19, P855, DOI 10.1016/j.chc.2010.07.005
   Coleman M., 1978, AUTISM REAPPRAISAL C
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Daley TC, 2002, J AUTISM DEV DISORD, V32, P13, DOI 10.1023/A:1017947922349
   Donaldson Susan O, 2011, J Child Adolesc Psychiatr Nurs, V24, P200, DOI 10.1111/j.1744-6171.2011.00300.x
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Gillberg C, 2006, J AUTISM DEV DISORD, V36, P429, DOI 10.1007/s10803-006-0081-6
   Gillberg C., 2000, BIOL AUTISTIC SYNDRO
   Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8
   Holliday-Willey L., 1999, PRETENDING NORMAL LI
   Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361
   Kamio Yoko, 2007, Nihon Rinsho, V65, P477
   Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x
   Kopp S., 1992, EUROPEAN CHILD ADOLE, V1, P89
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   LORD C, 1982, J AUTISM DEV DISORD, V12, P317, DOI 10.1007/BF01538320
   LORD C, 1985, J AUTISM DEV DISORD, V15, P185, DOI 10.1007/BF01531604
   Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048
   McCabe H, 2008, RES PRACT PERS SEV D, V33, P37
   MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216
   National Bureau of Statistics of China, 2012, NAT STAT POP
   Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466
   Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x
   Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
   Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
   Sun X., 2012, RES DEV DISABIL, V34, P440
   Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103
   Wakabayashi A, 2007, J AUTISM DEV DISORD, V37, P1823, DOI 10.1007/s10803-006-0316-6
   Wallis KE, 2008, ACTA PAEDIATR, V97, P539, DOI 10.1111/j.1651-2227.2008.00720.x
   Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029
   Williams JG, 2008, J AUTISM DEV DISORD, V38, P1731, DOI 10.1007/s10803-008-0558-6
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Wing L., 1976, EARLY CHILDHOOD AUTI
   WOLFF S, 1995, J CHILD PSYCHOL PSYC, V36, P793, DOI 10.1111/j.1469-7610.1995.tb01330.x
NR 50
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2137
EP 2146
DI 10.1007/s10803-014-2088-8
PG 10
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400005
PM 24756542
ER

PT J
AU Larson, JCG
   Suchy, Y
AF Larson, Jennifer C. Gidley
   Suchy, Yana
TI Does Language Guide Behavior in Children with Autism?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Self-directed speech; Motor sequence learning; Motor control
ID SCALE-ELECTRONIC VERSION; HIGH-FUNCTIONING AUTISM; TURN-TAPTAP TASK;
   INNER SPEECH USE; SPECTRUM DISORDERS; WORKING-MEMORY; DYSCONTROL SCALE;
   EXECUTIVE DYSFUNCTION; DIAGNOSTIC INTERVIEW; MOTOR
AB It is unknown if children with high-functioning autism (HFA) employ self-directed speech to guide motor sequencing and motor control, or if they can benefit from using self-directed speech when prompted to do so. Participants performed a three-movement sequence across three conditions: Natural Learning, Task-Congruent Verbalization (TCV), and Task-Incongruent Verbalization (TIV). TIV deleteriously impacted performance in the typically-developing group (n = 22), and not the HFA group (n = 21). TCV improved performance in both groups, but to a greater extent in the HFA group. These findings suggest that children with HFA do not initiate self-directed speech spontaneously, but can use language to guide behavior when prompted to do so.
C1 [Larson, Jennifer C. Gidley] Kennedy Krieger Inst, Dept Neuropsychol, Baltimore, MD 21231 USA.
   [Larson, Jennifer C. Gidley; Suchy, Yana] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
RP Larson, JCG (reprint author), Kennedy Krieger Inst, Dept Neuropsychol, 1750 E Fairmount Ave, Baltimore, MD 21231 USA.
EM jen.gidleylarson@gmail.com; yana.suchy@utah.edu
CR Akert K., 1964, FRONTAL GRANULAR COR, P353
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Baddeley A, 2002, PRINCIPLES FRONTAL L, P246
   Baddeley A., 1974, WORKING MEMORY
   Baddeley A, 2000, TRENDS COGN SCI, V4, P417, DOI 10.1016/S1364-6613(00)01538-2
   Baddeley A, 2001, J EXP PSYCHOL GEN, V130, P641, DOI 10.1037//0096-3445.130.4.641
   Baddeley A, 2003, J COMMUN DISORD, V36, P189, DOI 10.1016/S0021-9924(03)00019-4
   BADDELEY AD, 1983, PHILOS T ROY SOC B, V302, P311, DOI 10.1098/rstb.1983.0057
   Barkley R. A., 1997, ADHD NATURE SELF CON
   Barkley RA, 2001, NEUROPSYCHOL REV, V11, P1, DOI 10.1023/A:1009085417776
   Belanger HG, 2005, ARCH CLIN NEUROPSYCH, V20, P183, DOI 10.1016/j.acn.2004.05.003
   Bigler ED, 2007, DEV NEUROPSYCHOL, V31, P217
   Caron MJ, 2004, NEUROPSYCHOLOGIA, V42, P467, DOI 10.1016/j.neuropsychologia.2003.08.015
   Carruthers P, 2002, BEHAV BRAIN SCI, V25, P657, DOI 10.1017/S0140525X02000122
   Catalan MJ, 1998, BRAIN, V121, P253, DOI 10.1093/brain/121.2.253
   Christ S. E., 2011, NEUROPSYCHOLOGY, V25, P609
   Constantino J., 2003, SOCIAL RESPONSIVENES
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   DEWEY D, 1991, DEV NEUROPSYCHOL, V7, P197
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Edgin JO, 2005, J AUTISM DEV DISORD, V35, P729, DOI 10.1007/s10803-005-0020-y
   Emerson MJ, 2003, J MEM LANG, V48, P148, DOI 10.1016/S0749-596X(02)00511-9
   Gidley Larson J. C., 2006, AUTISM NEUROLOGICAL, P231
   Gifford E. V., 1996, ATTENTION MEMORY EXE, P297
   Glazebrook CM, 2006, MOTOR CONTROL, V10, P244
   Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
   Grandin T., 1995, THINKING PICTURES OT
   GRIGSBY J, 1992, PERCEPT MOTOR SKILL, V74, P883, DOI 10.2466/PMS.74.3.883-892
   Helstrup T, 2000, SCAND J PSYCHOL, V41, P209, DOI 10.1111/1467-9450.00189
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hilton CL, 2012, AUTISM, V16, P430, DOI 10.1177/1362361311423018
   Holland L, 2010, BRIT J DEV PSYCHOL, V28, P369, DOI 10.1348/026151009X424088
   HUGHES C, 1993, DEV PSYCHOL, V29, P498, DOI 10.1037/0012-1649.29.3.498
   Hughes C, 1996, J AUTISM DEV DISORD, V26, P99, DOI 10.1007/BF02276237
   HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2
   HURLBURT RT, 1994, PSYCHOL MED, V24, P385
   Joseph RM, 2005, DEV NEUROPSYCHOL, V27, P361, DOI 10.1207/s15326942dn2703_4
   Joseph RM, 2005, NEUROPSYCHOLOGIA, V43, P1400, DOI 10.1016/j.neuropsychologia.2005.01.010
   Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
   Kaye K., 1996, BEHAV DYSCONTROL SCA
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Kraybill ML, 2011, CLIN NEUROPSYCHOL, V25, P210, DOI 10.1080/13854046.2010.542489
   Kraybill ML, 2013, CLIN NEUROPSYCHOL, V27, P238, DOI 10.1080/13854046.2012.735702
   Leary MR, 1996, MENT RETARD, V34, P39
   Lidstone JSM, 2009, J AUTISM DEV DISORD, V39, P1222, DOI 10.1007/s10803-009-0731-6
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luria A. R., 1961, ROLE SPEECH REGULATI
   LURIA AR, 1959, WORD, V15, P341
   Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
   Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036
   Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
   Minshew NJ, 2005, J AUTISM DEV DISORD, V35, P45, DOI 10.1007/s10803-004-1030-x
   Mitchell P, 2004, INFANT CHILD DEV, V13, P185, DOI 10.1002/icd.348
   Mottron L, 2001, J CHILD PSYCHOL PSYC, V42, P253, DOI 10.1017/S0021963001006722
   Muller U, 2009, PRIVATE SPEECH, EXECUTIVE FUNCTIONING, AND THE DEVELOPMENT OF VERBAL SELF-REGULATION, P53
   OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027
   Ozonoff S, 2004, J AUTISM DEV DISORD, V34, P139, DOI 10.1023/B:JADD.0000022605.81989.cc
   Pelphrey K, 2004, MENT RETARD DEV D R, V10, P259, DOI 10.1002/mrdd
   Rapin I, 2003, BRAIN DEV-JPN, V25, P166, DOI 10.1016/S0387-7604(02)00191-2
   Rogers SJ, 1996, CHILD DEV, V67, P2060, DOI 10.2307/1131609
   Russell J., 1997, AUTISM EXECUTIVE DIS
   Russell J, 1999, J AUTISM DEV DISORD, V29, P103, DOI 10.1023/A:1023084425406
   Sattler J. M., 2008, RESOURCE GUIDE ACCOM, P32
   Sayhoun C., 2010, NEUROPSYCHOLOGIA, V48, P86
   Silk TJ, 2006, AM J PSYCHIAT, V163, P1440, DOI 10.1176/appi.ajp.163.8.1440
   Smith IM, 2007, COGN NEUROPSYCHOL, V24, P679, DOI 10.1080/02643290701669703
   Sokolov A. N., 1969, HDB CONT SOVIET PSYC, P531
   Sokolov A. N., 1968, INNER SPEECH THOUGHT
   Suchy Y, 2005, CLIN NEUROPSYCHOL, V19, P4, DOI 10.1080/13854040490888585
   Suchy Y, 2007, BRAIN INJURY, V21, P69, DOI 10.1080/02699050601149088
   Suchy Y, 2011, J CLIN EXP NEUROPSYC, V33, P92, DOI 10.1080/13803395.2010.493148
   Suchy Y, 2007, J CLIN EXP NEUROPSYC, V29, P648, DOI 10.1080/13803390600910506
   Suchy Y, 2010, J INT NEUROPSYCH SOC, V16, P26, DOI 10.1017/S1355617709990804
   TINSLEY VS, 1982, CHILD DEV, V53, P746, DOI 10.1111/j.1467-8624.1982.tb03449.x
   Vohs K. D., 2011, HDB SELF REGULATION, P283
   Vygotsky L. S., 1962, THOUGHT LANGUAGE
   Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
   Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8
   Wechsler D., 2003, MANUAL WECHSLER INTE, VFourth
   Wechsler D., 2002, WECHSLER INDIVIDUAL
   Whetherby A. M., 2004, J AUTISM DEV DISORD, V34, P473
   Whitehouse AJO, 2006, J CHILD PSYCHOL PSYC, V47, P857, DOI 10.1111/j.1469-7610.2006.01624.x
   Whiting H. T. A., 1992, APPROACHES STUDY MOT, P81
   Williams D, 2008, J CHILD PSYCHOL PSYC, V49, P51, DOI 10.1111/j.1469-7610.2007.01836.x
   Williams DM, 2010, J AUTISM DEV DISORD, V40, P907, DOI 10.1007/s10803-010-0936-8
   Willingham DB, 1998, PSYCHOL REV, V105, P558, DOI 10.1037/0033-295X.105.3.558
   Winsler A, 2007, J AUTISM DEV DISORD, V37, P1617, DOI 10.1007/s10803-006-0294-8
   Zelazo P. D., 1997, LANGUAGE STRUCTURE D, V12, P113
NR 90
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2147
EP 2161
DI 10.1007/s10803-014-2089-7
PG 15
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400006
ER

PT J
AU Bottema-Beutel, K
   Yoder, PJ
   Hochman, JM
   Watson, LR
AF Bottema-Beutel, Kristen
   Yoder, Paul J.
   Hochman, Julia M.
   Watson, Linda R.
TI The Role of Supported Joint Engagement and Parent Utterances in Language
   and Social Communication Development in Children with Autism Spectrum
   Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Parent-child interaction; Social
   communication; Language
ID YOUNG-CHILDREN; 2ND YEAR; ATTENTION; PREDICTORS; PLAY; RESPONSIVENESS;
   BEHAVIORS; IMITATION; LIFE
AB This study examined associations between three parent-child engagement states and social communication, expressive language, and receptive language at 8 month follow-up, in 63 preschool-age children with autism spectrum disorder. We extend the literature on supported joint engagement by dividing this state into higher order (HSJE) and lower order types, with HSJE involving greater reciprocity in toy play. We also examined parents' follow-in utterances that co-occurred with each state. We found that only HSJE predicts later social communication and expressive language, while object engagement predicts receptive language. HSJE combined with follow-in utterances (HSJE+FI) predicts all three outcomes when controlling for HSJE+FI in other engagement states. When controlling for total HSJE, HSJE+FI is predictive of receptive language.
C1 [Bottema-Beutel, Kristen] Boston Coll, Lynch Sch Educ, Chestnut Hill, MA 02467 USA.
   [Yoder, Paul J.; Hochman, Julia M.] Vanderbilt Univ, Dept Special Educ, Peabody Coll, Nashville, TN 37203 USA.
   [Watson, Linda R.] Univ N Carolina, Div Speech & Hearing Sci, Chapel Hill, NC 27599 USA.
RP Bottema-Beutel, K (reprint author), Boston Coll, Lynch Sch Educ, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA.
EM Kristen.bottema-beutel@bc.edu
CR Adamson LB, 2004, CHILD DEV, V75, P1171, DOI 10.1111/j.1467-8624.2004.00732.x
   Adamson LB, 2001, J APPL DEV PSYCHOL, V22, P439, DOI 10.1016/S0193-3973(01)00089-2
   Adamson LB, 2009, J AUTISM DEV DISORD, V39, P84, DOI 10.1007/s10803-008-0601-7
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   BAKEMAN R, 1984, CHILD DEV, V55, P1278, DOI 10.2307/1129997
   Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x
   Bloom L., 2001, MONOGRAPHS SOC RES C, V66, pvii
   Bruner J. S., 1983, CHILDS TALK LEARNING
   Carpenter M., 1998, MONOGRAPHS SOC RES C, V63
   Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Fenson L, 1993, MACARTHUR COMMUNICAT
   Gillespie-Lynch K, 2012, J AUTISM DEV DISORD, V42, P161, DOI 10.1007/s10803-011-1222-0
   HARRIS M, 1986, BRIT J DEV PSYCHOL, V4, P261
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
   Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   McDuffie A, 2010, J SPEECH LANG HEAR R, V53, P1026, DOI 10.1044/1092-4388(2009/09-0023)
   Mullen E, 1995, MULLEN SCALES EARLY
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
   RUSHTON JP, 1983, PSYCHOL BULL, V94, P18, DOI 10.1037//0033-2909.94.1.18
   Shumway S, 2009, J SPEECH LANG HEAR R, V52, P1139, DOI 10.1044/1092-4388(2009/07-0280)
   Sigman M., 1999, MONOGRAPHS SOC RES C, P64
   Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   StataCorp, 2013, STAT STAT SOFTW REL
   TAGERFLUSBERG H, 2001, MENT RETARD DEV D R, V7, P21, DOI 10.1002/1098-2779(200102)7:1<21::AID-MRDD1004>3.0.CO;2-3
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335
   Tamis-LeMonda CS, 2001, CHILD DEV, V72, P748, DOI 10.1111/1467-8624.00313
   Tapp J. T., 2003, PROCODERDV COMPUTER
   Tapp J. T., 2013, PROCODER MERGER COMP
   Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
   Trevarthen C., 1979, SPEECH BEGINNING INT, P321
   Trevarthen C., 1978, ACTION GESTURE SYMBO, P183
   Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
   Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
   Wetherby A. M., 2002, CSBS DP MANUAL
   Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Yoder P, 2010, OBSERVATIONAL MEASUR
   Yoder P. J., 2006, SOCIAL COMMUNICATION, P117
NR 44
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2162
EP 2174
DI 10.1007/s10803-014-2092-z
PG 13
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400007
PM 24658867
ER

PT J
AU Johnson, CR
   Turner, K
   Stewart, PA
   Schmidt, B
   Shui, A
   Macklin, E
   Reynolds, A
   James, J
   Johnson, SL
   Courtney, PM
   Hyman, SL
AF Johnson, Cynthia R.
   Turner, Kylan
   Stewart, Patricia A.
   Schmidt, Brianne
   Shui, Amy
   Macklin, Eric
   Reynolds, Anne
   James, Jill
   Johnson, Susan L.
   Courtney, Patty Manning
   Hyman, Susan L.
TI Relationships Between Feeding Problems, Behavioral Characteristics and
   Nutritional Quality in Children with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Feeding problems; Mealtime behaviors; Nutrition
ID AUTISM SPECTRUM DISORDERS; TYPICALLY DEVELOPING-CHILDREN; PERVASIVE
   DEVELOPMENTAL DISORDERS; FOOD SELECTIVITY; YOUNG-CHILDREN; MEALTIME
   BEHAVIORS; REPETITIVE BEHAVIORS; SENSORY SENSITIVITY;
   ASPERGERS-DISORDER; TREATMENT OUTCOMES
AB Many children with autism spectrum disorders (ASD) have co-occurring feeding problems. However, there is limited knowledge about how these feeding habits are related to other behavioral characteristics ubiqitious in ASD. In a relatively large sample of 256 children with ASD, ages 2-11, we examined the relationships between feeding and mealtime behaviors and social, communication, and cognitive levels as well repetitive and ritualistic behaviors, sensory behaviors, and externalizing and internalizing behaviors. Finally, we examined whether feeding habits were predictive of nutritional adequacy. In this sample, we found strong associations between parent reported feeding habits and (1) repetitive and ritualistic behaviors, (2) sensory features, and (3) externalizing and internalizing behavior. There was a lack of association between feeding behaviors and the social and communication deficits of ASD and cognitive levels. Increases in the degree of problematic feeding behaviors predicted decrements in nutritional adequacy.
C1 [Johnson, Cynthia R.; Turner, Kylan] Univ Pittsburgh, Autism Ctr, Sch Med, Pittsburgh, PA 15213 USA.
   [Stewart, Patricia A.; Schmidt, Brianne; Hyman, Susan L.] Univ Rochester, Dept Pediat, Sch Med, Rochester, NY 14642 USA.
   [Stewart, Patricia A.] Univ Rochester, Clin & Translat Sci Inst, Sch Med, Rochester, NY 14642 USA.
   [Shui, Amy; Macklin, Eric] Massachusetts Gen Hosp, MGH Biostat, Boston, MA 02114 USA.
   [Reynolds, Anne; Johnson, Susan L.] Univ Colorado, Aurora, CO 80045 USA.
   [James, Jill] Univ Arkansas Childrens Hosp, Little Rock, AR 72202 USA.
   [Courtney, Patty Manning] Cincinnati Childrens Hosp, Cincinnati, OH 45229 USA.
RP Johnson, CR (reprint author), Univ Pittsburgh, Autism Ctr, Sch Med, 3420 Fifth Ave, Pittsburgh, PA 15213 USA.
EM Cynthia.johnson@chp.edu
CR Achenbach T. M., 2002, CHILD BEHAV CHECKLIS
   Achenbach TM, 2001, MANUAL ACHENBACH SYS
   Ahearn WH, 2001, J AUTISM DEV DISORD, V31, P505, DOI 10.1023/A:1012221026124
   Allik H, 2006, J AUTISM DEV DISORD, V36, P585, DOI 10.1007/s10803-006-0099-9
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baio J., 2012, CTR DIS CONTROL PREV, V61
   Bandini LG, 2010, J PEDIATR-US, V157, P259, DOI 10.1016/j.jpeds.2010.02.013
   Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
   Bennetto L., 2012, INT M AUST RES TOR
   Bennetto L, 2007, BIOL PSYCHIAT, V62, P1015, DOI 10.1016/j.biopsych.2007.04.019
   Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
   Bodfish J. W., 2002, INT M AUT RES ORL FL
   Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Cermak SA, 2010, J AM DIET ASSOC, V110, P238, DOI 10.1016/j.jada.2009.10.032
   Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6
   CLARK JH, 1993, JPEN-PARENTER ENTER, V17, P284, DOI 10.1177/0148607193017003284
   Coltman A. E., 2013, Topics in Clinical Nutrition, V28, P145
   Coury D, 2009, CURR OPIN PEDIATR, V21, P828, DOI 10.1097/MOP.0b013e328331eaaa
   Crist W, 2001, J DEV BEHAV PEDIATR, V22, P279
   de Bildt A, 2005, J INTELL DISABIL RES, V49, P672, DOI 10.1111/j.1365-2788.2005.00711.x
   Dominick KC, 2007, RES DEV DISABIL, V28, P145, DOI 10.1016/j.ridd.2006.02.003
   Duarte CS, 2003, J AUTISM DEV DISORD, V33, P703, DOI 10.1023/B:JADD.0000006005.31818.1c
   Duggan CP, 2007, NEW ENGL J MED, V357, P392
   Dunn W, 1999, SENSORY PROFILE USER
   Elliott C., 2007, DIFFERENTIAL ABILITY
   Erinosho TO, 2013, J ACAD NUTR DIET, V113, P1084, DOI 10.1016/j.jand.2013.04.026
   Evans DW, 2005, CHILD PSYCHIAT HUM D, V36, P3, DOI 10.1007/s10578-004-3619-x
   Farrow CV, 2012, APPETITE, V58, P842, DOI 10.1016/j.appet.2012.01.017
   Guenther P. M., 2006, HLTH EATING INDEX 20
   Guenther PM, 2013, J ACAD NUTR DIET, V113, P569, DOI 10.1016/j.jand.2012.12.016
   Hyman Susan L, 2012, Pediatrics, V130 Suppl 2, pS145, DOI 10.1542/peds.2012-0900L
   Johnson S. L., 2013, FASEB J
   Kerwin ME, 1999, J PEDIATR PSYCHOL, V24, P193, DOI 10.1093/jpepsy/24.3.193
   Kerwin ME, 2005, CHILD HEALTH CARE, V34, P217, DOI 10.1207/s15326888chc3403_4
   Kientz MA, 1997, AM J OCCUP THER, V51, P530
   Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Laud RB, 2009, BEHAV MODIF, V33, P520, DOI 10.1177/0145445509346729
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Ledford J. R., 2006, FOCUS AUTISM OTHER D, V21, P153, DOI DOI 10.1177/10883576060210030401
   Lindsay RL, 2006, J INTELLECT DEV DIS, V31, P204, DOI 10.1080/13668250601006924
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lukens CT, 2008, J AUTISM DEV DISORD, V38, P342, DOI 10.1007/s10803-007-0401-5
   Manikam R, 2000, J CLIN GASTROENTEROL, V30, P34, DOI 10.1097/00004836-200001000-00007
   Martins Y, 2008, J AUTISM DEV DISORD, V38, P1878, DOI 10.1007/s10803-008-0583-5
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P759, DOI 10.1016/j.rasd.2009.02.005
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P455, DOI 10.1016/j.rasd.2008.09.005
   Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P474, DOI 10.1016/j.rasd.2010.06.012
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   Mullen E, 1995, MULLEN SCALES EARLY
   Nadon G, 2011, AUTISM, V15, P98, DOI 10.1177/1362361309348943
   Nadon G, 2011, AUTISM RES TREAT, V2011
   Patton SR, 2013, J ACAD NUTR DIET, V113, P258, DOI 10.1016/j.jand.2012.09.013
   Patzold LM, 1998, J PAEDIATR CHILD H, V34, P528
   Pineles SL, 2010, PEDIATRICS, V126, pE967, DOI 10.1542/peds.2009-2975
   Polimeni MA, 2005, J INTELL DISABIL RES, V49, P260, DOI 10.1111/j.1365-2788.2005.00642.x
   Provost B, 2010, PHYS OCCUP THER PEDI, V30, P220, DOI 10.3109/01942631003757669
   Rogers LG, 2012, J DEV PHYS DISABIL, V24, P19, DOI 10.1007/s10882-011-9252-2
   Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
   Roid G. H., 2003, STANFORD BINET INTEL
   Schakel SF, 2001, J FOOD COMPOS ANAL, V14, P315, DOI 10.1006/jfca.2001.0992
   Schmitt L., 2008, Topics in Clinical Nutrition, V23, P23
   Schreck KA, 2004, J AUTISM DEV DISORD, V34, P433, DOI 10.1023/B:JADD.0000037419.78531.86
   Schreck KA, 2006, RES DEV DISABIL, V27, P353, DOI 10.1016/j.ridd.2005.03.005
   Schwartz R. H., 2011, OPEN J PEDIAT, V1, P51, DOI DOI 10.4236/OJPED.2011.14014
   Seiverling LJ, 2011, J DEV PHYS DISABIL, V23, P303, DOI 10.1007/s10882-011-9229-1
   Sharp WG, 2010, CLIN CHILD FAM PSYCH, V13, P348, DOI 10.1007/s10567-010-0079-7
   Sharp WG, 2009, BEHAV INTERVENT, V24, P157, DOI 10.1002/bin.282
   Sivertsen B, 2012, AUTISM, V16, P139, DOI 10.1177/1362361311404255
   Smith AA, 2005, NUTRITION, V21, P14, DOI 10.1016/j.nut.2004.09.004
   Suarez M. A., 2012, OPEN J OCCUPATIONAL, V1
   Tomchek SD, 2007, AM J OCCUP THER, V61, P190
   Twachtman-Reilly J, 2008, LANG SPEECH HEAR SER, V39, P261, DOI 10.1044/0161-1461(2008/025)
   Uyanik O, 2006, CHILD CARE HLTH DEV, V32, P601, DOI 10.1111/j.1365-2214.2006.00586.x
   Volkert VM, 2010, J APPL BEHAV ANAL, V43, P155, DOI 10.1901/jaba.2010.43-155
   Wiggins LD, 2009, J AUTISM DEV DISORD, V39, P1087, DOI 10.1007/s10803-009-0711-x
   Williams P G, 2000, Pediatr Nurs, V26, P259
NR 79
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2175
EP 2184
DI 10.1007/s10803-014-2095-9
PG 10
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400008
PM 24664635
ER

PT J
AU Brown-Lavoie, SM
   Viecili, MA
   Weiss, JA
AF Brown-Lavoie, S. M.
   Viecili, M. A.
   Weiss, J. A.
TI Sexual Knowledge and Victimization in Adults with Autism Spectrum
   Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Sexual knowledge; Sexual victimization;
   Asperger syndrome; Education
ID HIGH-FUNCTIONING AUTISM; WEAK CENTRAL COHERENCE; EXPERIENCES SURVEY;
   YOUNG-ADULTS; CONDOM USE; PARENTAL PERSPECTIVE; COGNITIVE PHENOTYPE;
   HEALTH KNOWLEDGE; COLLEGE-STUDENTS; BEHAVIOR
AB There is a significant gap in understanding the risk of sexual victimization in individuals with autism spectrum disorders (ASD) and the variables that contribute to risk. Age appropriate sexual interest, limited sexual knowledge and experiences, and social deficits, may place adults with ASD at increased risk. Ninety-five adults with ASD and 117 adults without ASD completed questionnaires regarding sexual knowledge sources, actual knowledge, perceived knowledge, and sexual victimization. Individuals with ASD obtained less of their sexual knowledge from social sources, more sexual knowledge from non-social sources, had less perceived and actual knowledge, and experienced more sexual victimization than controls. The increased risk of victimization by individuals with ASD was partially mediated by their actual knowledge. The link between knowledge and victimization has important clinical implications for interventions.
C1 [Brown-Lavoie, S. M.; Viecili, M. A.; Weiss, J. A.] York Univ, Dept Psychol, Toronto, ON M3J 1P3, Canada.
RP Weiss, JA (reprint author), York Univ, Dept Psychol, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM jonweiss@yorku.ca
CR Albrecht G, 1996, HEALTH CARE ANAL, V4, P284, DOI 10.1002/(SICI)1099-1042(199611)4:4<284::AID-HCA194>3.0.CO;2-W
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Aspy CB, 2007, J ADOLESCENCE, V30, P449, DOI 10.1016/j.adolescence.2006.04.007
   Ballan MS, 2012, J AUTISM DEV DISORD, V42, P676, DOI 10.1007/s10803-011-1293-y
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Berten H, 2009, J ADOLESCENCE, V32, P1303, DOI 10.1016/j.adolescence.2008.12.004
   Bleakley A, 2009, AM J HEALTH BEHAV, V33, P37
   Brennan S., 2008, SEXUAL ASSAULT CANAD
   Briskman J, 2001, J CHILD PSYCHOL PSYC, V42, P309, DOI 10.1111/1469-7610.00724
   Byers ES, 2013, AUTISM, V17, P418, DOI 10.1177/1362361311431950
   Clopper CG, 2012, J AUTISM DEV DISORD, V42, P740, DOI 10.1007/s10803-011-1305-y
   DICLEMENTE RJ, 1989, J SEX RES, V26, P188
   Frith U., 1989, AUTISM THEORY MIND, P33
   Fujiura GT, 2012, INTELLECT DEV DISAB, V50, P352, DOI 10.1352/1934-9556-50.4.352
   Gilmour L, 2012, RES AUTISM SPECT DIS, V6, P313, DOI 10.1016/j.rasd.2011.06.003
   Happe F, 2001, J CHILD PSYCHOL PSYC, V42, P299, DOI 10.1111/1469-7610.00723
   Hellemans H, 2007, J AUTISM DEV DISORD, V37, P260, DOI 10.1007/s10803-006-0159-1
   Henault I., 2005, ASPERGERS SYNDROME S
   Holtzman D, 1995, FAM PLANN PERSPECT, V27, P235, DOI 10.2307/2136175
   Humphrey JA, 2000, J ADOLESCENT HEALTH, V27, P419, DOI 10.1016/S1054-139X(00)00168-3
   Hutchinson MK, 2003, J ADOLESCENT HEALTH, V33, P98, DOI 10.1016/S1054-139X(03)00183-6
   Institute of Medicine, 2009, STAT US HLTH IND LET
   JOSEPH JM, 1995, AM ANN DEAF, V140, P338
   Konstantareas MM, 1997, J AUTISM DEV DISORD, V27, P397, DOI 10.1023/A:1025805405188
   KOSS MP, 1987, J CONSULT CLIN PSYCH, V55, P162, DOI 10.1037/0022-006X.55.2.162
   KOSS MP, 1985, J CONSULT CLIN PSYCH, V53, P422, DOI 10.1037//0022-006X.53.3.422
   Mandell DS, 2005, CHILD ABUSE NEGLECT, V29, P1359, DOI 10.1016/j.chiabu.2005.06.006
   MCCONAGHY N, 1993, AUST NZ J PSYCHIAT, V27, P686, DOI 10.3109/00048679309075832
   McVilly KR, 2000, J INTELLECT DEV DIS, V25, P19
   Mehzabin P, 2011, RES AUTISM SPECT DIS, V5, P614, DOI 10.1016/j.rasd.2010.07.006
   Meister C., 1994, CANADIAN J HUMAN SEX, V3, P283
   OUSLEY OY, 1991, J AUTISM DEV DISORD, V21, P471, DOI 10.1007/BF02206871
   Pedersen L., 2004, SEXUALITY AUTISM NAT
   Tourangeau R, 2003, MEASUREMENT PROBLEMS IN CRIMINAL JUSTICE RESEARCH, WORKSHOP SUMMARY, P10
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
   Rock EM, 2005, PEDIATRICS, V115, P667, DOI 10.1542/peds.2004-0139
   Ronning JA, 2009, SOC PSYCH PSYCH EPID, V44, P15, DOI 10.1007/s00127-008-0395-0
   RUBLE LA, 1993, ARCH SEX BEHAV, V22, P229, DOI 10.1007/BF01541768
   Ryan S, 2007, YOUTH SOC, V39, P182, DOI 10.1177/0044118X06296907
   Sable MR, 2006, J AM COLL HEALTH, V55, P157, DOI 10.3200/JACH.55.3.157-162
   Sevlever M, 2013, SEX DISABIL, V31, P189, DOI 10.1007/s11195-013-9286-8
   Shtayermman Oren, 2007, Issues Compr Pediatr Nurs, V30, P87, DOI 10.1080/01460860701525089
   Stokes M, 2007, J AUTISM DEV DISORD, V37, P1969, DOI 10.1007/s10803-006-0344-2
   Stokes MA, 2005, AUTISM, V9, P266, DOI 10.1177/1362361305053258
   Sullivan PM, 2000, CHILD ABUSE NEGLECT, V24, P1257, DOI 10.1016/S0145-2134(00)00190-3
   Tector A., 2010, BRIT J SPECIAL ED, V37, P69
   Testa M, 2004, PSYCHOL WOMEN QUART, V28, P256, DOI 10.1111/j.1471-6402.2004.00143.x
   Tjaden P., 2000, FULL REPORT PREVALEN
   Travers J, 2010, EDUC TRAIN AUTISM DE, V45, P284
   Turner CF, 1998, SCIENCE, V280, P867, DOI 10.1126/science.280.5365.867
   van der Vegt E., 2013, INT M AUT RES SAN SE
   VanBourgondien ME, 1997, J AUTISM DEV DISORD, V27, P113, DOI 10.1023/A:1025883622452
   Walsh JL, 2010, J SEX RES, V47, P285, DOI 10.1080/00224490902916009
   Weinstein RB, 2008, INT J SEX HEALTH, V20, P212, DOI 10.1080/19317610802240279
   Whitaker DJ, 2000, J ADOLESCENT RES, V15, P251, DOI 10.1177/0743558400152004
   Whitaker DJ, 1999, FAM PLANN PERSPECT, V31, P117, DOI 10.2307/2991693
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 58
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2185
EP 2196
DI 10.1007/s10803-014-2093-y
PG 12
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400009
PM 24664634
ER

PT J
AU Koegel, RL
   Kim, S
   Koegel, LK
AF Koegel, Robert L.
   Kim, Sunny
   Koegel, Lynn Kern
TI Training Paraprofessionals to Improve Socialization in Students with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Paraprofessional; Training; Autism; Socialization; School
ID INCLUSIVE SETTINGS; SPECIAL-EDUCATION; SCHOOL SETTINGS; AUTISM;
   CHILDREN; DISABILITIES; PEERS; PARAEDUCATORS; CLASSROOMS; INTERESTS
AB An important line of research relates to whether school personnel, such as paraprofessionals, who are present during unstructured social periods, such as lunch-recess, could successfully implement interventions to improve socialization between students with ASD and their typical peers in a group setting. Therefore, within the context of a multiple baseline across participants design, we assessed whether training paraprofessionals to provide social interventions would enhance social development in students with ASD in a group setting. Results showed that paraprofessionals who were not providing any social opportunities during baseline were able to meet fidelity of implementation following a brief training. Consequently, the children with ASD increased their levels of engagement and rates of initiation with typically developing peers following intervention. Implications for training paraprofessionals to implement effective social interventions for students with ASD are discussed.
C1 [Koegel, Robert L.; Kim, Sunny; Koegel, Lynn Kern] Univ Calif Santa Barbara, Grad Sch Educ, Koegel Autism Ctr, Santa Barbara, CA 93106 USA.
RP Koegel, RL (reprint author), Univ Calif Santa Barbara, Grad Sch Educ, Koegel Autism Ctr, Santa Barbara, CA 93106 USA.
EM Koegel@education.ucsb.edu
CR Bailey J. S., 2002, RES METHODS APPL BEH
   Baker MJ, 1998, J ASSOC PERS SEVERE, V23, P300, DOI 10.2511/rpsd.23.4.300
   Barlow D., 2009, SINGLE CASE EXPT DES
   Bauminger H., 2000, CHILD DEV, V71, P447
   Carter W., 2009, REM SPEC EDUC, V30, P359
   COHEN JM, 1977, SOCIOL EDUC, V50, P227, DOI 10.2307/2112497
   DiSalvo C., 2002, FOCUS AUTISM OTHER D, V17, P198, DOI DOI 10.1177/10883576020170040201
   Downing JE, 2000, REM SPEC EDUC, V21, P171, DOI 10.1177/074193250002100308
   DUGAN E, 1995, J APPL BEHAV ANAL, V28, P175, DOI 10.1901/jaba.1995.28-175
   Feld S. L., 1982, AM SOCIOL REV, V47, P791
   Fisher M, 2012, REM SPEC EDUC, V33, P287, DOI 10.1177/0741932510397762
   Giangreco M. F., 2010, EXCEPTIONALITY, V10, P47, DOI 10.1207/S15327035EX1001_4
   Giangreco MF, 1997, EXCEPT CHILDREN, V64, P7
   Giangreco MF, 2001, EXCEPT CHILDREN, V68, P45
   Harper CB, 2008, J AUTISM DEV DISORD, V38, P815, DOI 10.1007/s10803-007-0449-2
   Horner RH, 2005, EXCEPT CHILDREN, V71, P165
   JONES KH, 1993, REM SPEC EDUC, V14, P7
   Jull S, 2011, J POSIT BEHAV INTERV, V13, P17, DOI 10.1177/1098300709358111
   Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
   Kim S., 2012, IMPROVE SOCIALIZATIO
   Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P174, DOI 10.2511/rpsd.24.3.174
   Koegel LK, 2012, J POSIT BEHAV INTERV, V14, P220, DOI 10.1177/1098300712437042
   Koegel LK, 2001, BEHAV MODIF, V25, P745, DOI 10.1177/0145445501255005
   Koegel R, 2013, J AUTISM DEV DISORD, V43, P2121, DOI 10.1007/s10803-013-1765-3
   Koegel R. L., 2012, PRT POCKET GUIDE
   Koegel R. L., 2009, HDB POSITIVE BEHAV S, P149
   Koegel RL, 2005, RES PRACT PERS SEV D, V30, P93, DOI 10.2511/rpsd.30.2.93
   Koegel RL, 2012, J POSIT BEHAV INTERV, V14, P133, DOI 10.1177/1098300712437043
   Koegel RL, 2003, EVIDENCE-BASED PSYCHOTHERAPIES FOR CHILDREN AND ADOLESCENTS, P341
   Lewis KC, 2005, REV RES EDUC, V29, P131, DOI 10.3102/0091732X029001131
   Locke J., 2010, J RES SPECIAL ED NEE, V10, P74, DOI DOI 10.1111/J.1471-3802.2010.01148.X
   Causton-Theoharis JN, 2005, EXCEPT CHILDREN, V71, P431
   Marks SU, 1999, EXCEPT CHILDREN, V65, P315
   Feldman EK, 2013, J POSIT BEHAV INTERV, V15, P169, DOI 10.1177/1098300712457421
   Mazurik-Charles R., 2010, J INSTRUCTIONAL PSYC, V37, P161
   Patterson K. B., 2006, TEACHING EXCEPTIONAL, V2, P1
   Pickett A. L., 1997, TEACHER ED SPECIAL E, V20, P61
   Riggs CG, 2001, J SPEC EDUC, V35, P54, DOI 10.1177/002246690103500106
   Robinson SE, 2011, FOCUS AUTISM DEV DIS, V26, P105, DOI 10.1177/1088357611407063
   Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
   Storey K., 1993, EXCEPTIONALITY, V4, P1, DOI DOI 10.1207/S15327035EX0401_
   TREMBLAY A, 1981, BEHAV MODIF, V5, P237, DOI 10.1177/014544558152006
   Werts MG, 2001, EDUC TRAIN MENT RET, V36, P424
   Young B., 1997, FOCUS AUTISM OTHER D, V12, P31
NR 44
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2197
EP 2208
DI 10.1007/s10803-014-2094-x
PG 12
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400010
PM 24671749
ER

PT J
AU Hanaie, R
   Mohri, I
   Kagitani-Shimono, K
   Tachibana, M
   Matsuzaki, J
   Watanabe, Y
   Fujita, N
   Taniike, M
AF Hanaie, Ryuzo
   Mohri, Ikuko
   Kagitani-Shimono, Kuriko
   Tachibana, Masaya
   Matsuzaki, Junko
   Watanabe, Yoshiyuki
   Fujita, Norihiko
   Taniike, Masako
TI Abnormal Corpus Callosum Connectivity, Socio-communicative Deficits, and
   Motor Deficits in Children with Autism Spectrum Disorder: A Diffusion
   Tensor Imaging Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Diffusion tensor imaging; Tractography; Corpus callosum; Autism spectrum
   disorder; Motor function
ID HIGH-FUNCTIONING AUTISM; LANGUAGE-ASSOCIATION CORTEX; WHITE-MATTER
   INTEGRITY; DTI TRACTOGRAPHY; BRAIN VOLUME; OPTIC-NERVE; SPINAL-CORD;
   MRI; PARCELLATION; IMPAIRMENT
AB In addition to social and communicative deficits, many studies have reported motor deficits in autism spectrum disorder (ASD). This study investigated the macro and microstructural properties of the corpus callosum (CC) of 18 children with ASD and 12 typically developing controls using diffusion tensor imaging tractography. We aimed to explore whether abnormalities of the CC were related to motor deficits, as well as social and communication deficits in children with ASD. The ASD group displayed abnormal macro and microstructure of the total CC and its subdivisions and its structural properties were related to socio-communicative deficits, but not to motor deficits in ASD. These findings advance our understanding of the contributions of the CC to ASD symptoms.
C1 [Hanaie, Ryuzo; Mohri, Ikuko; Kagitani-Shimono, Kuriko; Tachibana, Masaya; Taniike, Masako] Osaka Univ, Div Dev Neurosci, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan.
   [Mohri, Ikuko; Matsuzaki, Junko; Taniike, Masako] Osaka Univ, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan.
   [Mohri, Ikuko; Kagitani-Shimono, Kuriko; Tachibana, Masaya; Taniike, Masako] Osaka Univ, Grad Sch Med, Dept Pediat, Suita, Osaka 5650871, Japan.
   [Watanabe, Yoshiyuki; Fujita, Norihiko] Osaka Univ, Grad Sch Med, Dept Diagnost & Intervent Radiol, Suita, Osaka 5650871, Japan.
RP Taniike, M (reprint author), Osaka Univ, Div Dev Neurosci, United Grad Sch Child Dev, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM masako@kokoro.med.osaka-u.ac.jp
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Aoki Y, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-25
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Beaule V, 2012, NEURAL PLAST, DOI 10.1155/2012/627816
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Bloom JS, 2005, NEUROPSYCHOL REV, V15, P59, DOI 10.1007/s11065-005-6252-y
   Budde MD, 2009, J NEUROSCI, V29, P2805, DOI 10.1523/JNEUROSCI.4605-08.2009
   Cardinale RC, 2013, JAMA PSYCHIAT, V70, P975, DOI 10.1001/jamapsychiatry.2013.382
   Casanova MF, 2009, J AUTISM DEV DISORD, V39, P751, DOI 10.1007/s10803-008-0681-4
   Cheng YW, 2010, NEUROIMAGE, V50, P873, DOI 10.1016/j.neuroimage.2010.01.011
   Clawson A, 2015, J AUTISM DEV DISORD, V45, P363, DOI 10.1007/s10803-013-1895-7
   Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
   Courchesne E, 2001, NEUROLOGY, V57, P245
   De Fosse L, 2004, ANN NEUROL, V56, P757, DOI 10.1002/ana.20275
   de Laat KF, 2011, BRAIN, V134, P73, DOI 10.1093/brain/awq343
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   Douaud G, 2011, NEUROIMAGE, V55, P880, DOI 10.1016/j.neuroimage.2010.12.008
   Eliassen JC, 2000, BRAIN, V123, P2501, DOI 10.1093/brain/123.12.2501
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Frazier TW, 2012, J AUTISM DEV DISORD, V42, P2312, DOI 10.1007/s10803-012-1478-z
   Freitag CM, 2009, BIOL PSYCHIAT, V66, P316, DOI 10.1016/j.biopsych.2009.03.011
   Gage NM, 2009, J NEURODEV DISORD, V1, P205, DOI 10.1007/s11689-009-9010-2
   Glazebrook CM, 2009, AUTISM, V13, P411, DOI 10.1177/1362361309105659
   Hanaie R, 2013, CEREBELLUM, V12, P645, DOI 10.1007/s12311-013-0475-x
   Hardan AY, 2009, PSYCHIAT RES-NEUROIM, V174, P57, DOI 10.1016/j.pscychresns.2009.03.005
   Hardan AY, 2009, BIOL PSYCHIAT, V66, P320, DOI 10.1016/j.biopsych.2009.04.024
   Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
   Heim S, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00534
   Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
   Herbert MR, 2002, ANN NEUROL, V52, P588, DOI 10.1002/ana.10349
   Hofer S, 2006, NEUROIMAGE, V32, P989, DOI 10.1016/j.neuroimage.2006.05.044
   Huang H, 2004, MAGNET RESON MED, V52, P559, DOI 10.1002/mrm.20147
   Huang H, 2005, NEUROIMAGE, V26, P195, DOI 10.1016/j.neuroimage.2005.01.019
   Innocenti GM, 2009, EXP BRAIN RES, V192, P417, DOI 10.1007/s00221-008-1484-8
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
   Johnson Beth P, 2012, Front Integr Neurosci, V6, P99, DOI 10.3389/fnint.2012.00099
   Jones DK, 2013, NEUROIMAGE, V73, P239, DOI 10.1016/j.neuroimage.2012.06.081
   Kana RK, 2014, SOC COGN AFFECT NEUR, V9, P98, DOI 10.1093/scan/nss106
   Keary CJ, 2009, J AUTISM DEV DISORD, V39, P834, DOI 10.1007/s10803-009-0689-4
   Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
   Knaus TA, 2009, BRAIN IMAGING BEHAV, V3, P51, DOI 10.1007/s11682-008-9048-x
   Kumar A, 2010, CEREB CORTEX, V20, P2103, DOI 10.1093/cercor/bhp278
   Lau YC, 2013, J AUTISM DEV DISORD, V43, P1106, DOI 10.1007/s10803-012-1653-2
   Leary MR, 1996, MENT RETARD, V34, P39
   Lebel C, 2012, MAGN RESON MED, V68, P474, DOI 10.1002/mrm.23254
   Lebel C, 2010, NEUROIMAGE, V52, P20, DOI 10.1016/j.neuroimage.2010.03.072
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Minshew NJ, 2004, NEUROLOGY, V63, P2056
   Moes P, 2009, CHILD CARE HLTH DEV, V35, P656, DOI 10.1111/j.1365-2214.2009.00942.x
   Mori S, 1999, ANN NEUROL, V45, P265, DOI 10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3
   Mostofsky SH, 2011, NEUROSCIENTIST, V17, P437, DOI 10.1177/1073858410392381
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Noriuchi M, 2010, BRAIN RES, V1362, P141, DOI 10.1016/j.brainres.2010.09.051
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Pannek K, 2010, NEUROIMAGE, V50, P1044, DOI 10.1016/j.neuroimage.2010.01.020
   Park HJ, 2008, HUM BRAIN MAPP, V29, P503, DOI 10.1002/hbm.20314
   Paus T, 2009, FRONT NEUROANAT, V3, DOI 10.3389/neuro.05.014.2009
   Prigge MBD, 2013, RES AUTISM SPECT DIS, V7, P221, DOI 10.1016/j.rasd.2012.09.007
   Qiu AQ, 2010, J AM ACAD CHILD PSY, V49, P539, DOI 10.1016/j.jaac.2010.02.012
   Rademaker KJ, 2004, SEMIN PERINATOL, V28, P279, DOI 10.1053/j.semperi.2004.08.005
   Redcay E, 2008, NEUROSCI BIOBEHAV R, V32, P123, DOI 10.1016/j.neubiorev.2007.06.004
   Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
   Russo B., 2012, NEUROIMAGE AMST, DOI [10.1016/j.nicl.2012.09.001, DOI 10.1016/J.NICL.2012.09.001]
   Schwartz ED, 2005, NEUROREPORT, V16, P73, DOI 10.1097/00001756-200501190-00017
   Shukla DK, 2010, J AM ACAD CHILD PSY, V49, P1269, DOI 10.1016/j.jaac.2010.08.018
   Song SK, 2003, NEUROIMAGE, V20, P1714, DOI 10.1016/j.neuroimage.2003.07.005
   Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006
   Tournier JD, 2011, MAGN RESON MED, V65, P1532, DOI 10.1002/mrm.22924
   Townsend J, 1996, DEV PSYCHOPATHOL, V8, P563
   Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
   Vidal CN, 2006, BIOL PSYCHIAT, V60, P218, DOI 10.1016/j.biopsych.2005.11.011
   Vigneau M, 2006, NEUROIMAGE, V30, P1414, DOI 10.1016/j.neuroimage.2005.11.002
   Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022
   Waiter GD, 2005, NEUROIMAGE, V24, P455, DOI 10.1016/j.neuroimage.2004.08.049
   Wakana S, 2007, NEUROIMAGE, V36, P630, DOI 10.1016/j.neuroimage.2007.02.049
   Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8
   Williams DL, 2013, AUTISM RES, V6, P288, DOI 10.1002/aur.1291
   Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
   Wu QZ, 2007, NEUROIMAGE, V37, P1138, DOI 10.1016/j.neuroimage.2007.06.029
   Yendiki A., 2013, NEUROIMAGE C, V88C, P79, DOI DOI 10.1016/J.NEUROIMAGE.2013.11.027
   ZWARTS MJ, 1995, MUSCLE NERVE, V18, P1244, DOI 10.1002/mus.880181105
NR 83
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2209
EP 2220
DI 10.1007/s10803-014-2096-8
PG 12
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400011
PM 24710811
ER

PT J
AU Ben-Itzchak, E
   Watson, LR
   Zachor, DA
AF Ben-Itzchak, Esther
   Watson, Linda R.
   Zachor, Ditza A.
TI Cognitive Ability is Associated with Different Outcome Trajectories in
   Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Early intensive behavioral intervention;
   Autism severity; Adaptive skills; Cognitive ability
ID INTENSIVE BEHAVIORAL INTERVENTION; YOUNG-CHILDREN; PREDICTORS; SCHOOL;
   SEVERITY
AB Variability in clinical expression and in intervention outcome has been described in autism spectrum disorder (ASD). The study examined progress after 1 and 2 years of intervention and compared the impact of baseline cognitive ability on outcome trajectories in 46 children (m = 25.5 months) with ASD. The entire group showed a gradual decrease in autism severity and increase in verbal cognitive scores. Only the low cognitive scores (DQ < 70) group significantly improved in fine motor and receptive language scores. Significant gains in adaptive skills were found only for the high cognitive scores (DQ a parts per thousand yen70) group after 2 years of intervention. The entire group progressed with intervention, but only children with higher cognitive levels at baseline transferred their acquired socio-communication skills into daily functioning.
C1 [Ben-Itzchak, Esther] Ariel Univ, Dept Commun Disorders, IL-40700 Ariel, Israel.
   [Ben-Itzchak, Esther] Assaf Harofeh Med Ctr, Autism Ctr, IL-70300 Zerifin, Israel.
   [Watson, Linda R.] Univ N Carolina, Sch Med, Dept Allied Hlth Sci, Chapel Hill, NC USA.
   [Zachor, Ditza A.] Assaf Harofeh Med Ctr, Dept Pediat, Autism Ctr, IL-70300 Zerifin, Israel.
   [Zachor, Ditza A.] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
RP Zachor, DA (reprint author), Assaf Harofeh Med Ctr, Dept Pediat, Autism Ctr, IL-70300 Zerifin, Israel.
EM dzachor@bezeqint.net
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ben Itzchak E, 2011, RES AUTISM SPECT DIS, V5, P345, DOI 10.1016/j.rasd.2010.04.018
   Ben-Itzchak E, 2007, RES DEV DISABIL, V28, P287, DOI 10.1016/j.ridd.2006.03.002
   Ben Itzchak E, 2009, RES AUTISM SPECT DIS, V3, P967, DOI 10.1016/j.rasd.2009.05.001
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, P145, DOI DOI 10.1097/00004703-200604002-00013
   Davies G, 2011, MOL PSYCHIATR, V16, P996, DOI 10.1038/mp.2011.85
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Eaves LC, 2004, J AUTISM DEV DISORD, V34, P367, DOI 10.1023/B:JADD.0000037414.33270.a8
   Eikeseth S, 2002, BEHAV MODIF, V26, P49, DOI 10.1177/0145445502026001004
   Eikeseth S, 2007, BEHAV MODIF, V31, P264, DOI 10.1177/0145445506291396
   Eldevik S, 2012, J AUTISM DEV DISORD, V42, P210, DOI 10.1007/s10803-011-1234-9
   Eldevik S, 2010, AJIDD-AM J INTELLECT, V115, P381, DOI 10.1352/1944-7558-115.5.381
   Eldevik S, 2006, J AUTISM DEV DISORD, V36, P211, DOI 10.1007/s10803-005-0058-x
   Fernell E, 2011, RES DEV DISABIL, V32, P2092, DOI 10.1016/j.ridd.2011.08.002
   Gabriels RL, 2007, RES AUTISM SPECT DIS, V1, P291, DOI 10.1016/j.rasd.2006.11.004
   Gabriels RL, 2001, AUTISM, V5, P407, DOI 10.1177/1362361301005004006
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Grindle CF, 2012, BEHAV MODIF, V36, P298, DOI 10.1177/0145445512441199
   Hayward D, 2009, AUTISM, V13, P613, DOI 10.1177/1362361309340029
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
   Hus V, 2014, J AUTISM DEV DISORD, V44, P2400, DOI 10.1007/s10803-012-1719-1
   Kovshoff H, 2011, BEHAV MODIF, V35, P427, DOI 10.1177/0145445511405513
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Leaf R., 1999, WORK PROGR BEHAV MAN
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Magiati I, 2012, NEUROPSYCHIATRY-LOND, V2, P543, DOI 10.2217/NPY.12.59
   Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
   Magiati I, 2011, RES AUTISM SPECT DIS, V5, P1016, DOI 10.1016/j.rasd.2010.11.007
   Maurice C., 1996, BEHAV INTERVENTION Y
   Mullen E, 1995, MULLEN SCALES EARLY
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Sparrow S., 2005, VINELAND 2 ADAPTIVE, V2nd
   Szatmari P, 2003, J CHILD PSYCHOL PSYC, V44, P520, DOI 10.1111/1469-7610.00141
   Thurm A, 2007, J AUTISM DEV DISORD, V37, P1721, DOI 10.1007/s10803-006-0300-1
   Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
   Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
   Zachor DA, 2010, RES AUTISM SPECT DIS, V4, P425, DOI 10.1016/j.rasd.2009.10.013
   Zachor DA, 2007, RES AUTISM SPECT DIS, V1, P304, DOI 10.1016/j.rasd.2006.12.001
NR 40
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2221
EP 2229
DI 10.1007/s10803-014-2091-0
PG 9
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400012
PM 24710810
ER

PT J
AU Chabani, E
   Hommel, B
AF Chabani, Ellahe
   Hommel, Bernhard
TI Visuospatial Processing in Children with Autism: No Evidence for
   (Training-Resistant) Abnormalities
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Visual spatial; Visualization; School based intervention; Response to
   intervention; Computer based instruction
ID COMPUTER-ASSISTED-INSTRUCTION; HIGH-FUNCTIONING AUTISM; EARLY BEHAVIORAL
   INTERVENTION; SUPERIOR VISUAL-SEARCH; WEAK CENTRAL COHERENCE; SPECTRUM
   DISORDERS; ENHANCED DISCRIMINATION; ASPERGERS-DISORDER; LITERACY SKILLS;
   FORM SIMILARITY
AB Individuals with autism spectrum disorders (ASDs) have been assumed to show evidence of abnormal visuospatial processing, which has been attributed to a failure to integrate local features into coherent global Gestalts and/or to a bias towards local processing. As the available data are based on baseline performance only, which does not provide insight into cognitive/neural plasticity and actual cognitive potential, we investigated how training-resistant possible visuospatial processing differences between children with and without ASD are. In particular, we studied the effect of computerized versus face-to-face visuospatial training in a group of normally intelligent children with ASD and typically developing children as control. Findings show that (a) children with and without ASD do not differ much in visuospatial processing (as assessed by a tangram-like task) and the few differences we observed were all eliminated by training; (b) training can improve visuospatial processing (equally) in both children with ASD and normally developing children; and (c) computer-based and face-to-face training was equally effective.
C1 [Chabani, Ellahe; Hommel, Bernhard] Leiden Univ, Inst Psychol, Leiden, Netherlands.
   [Hommel, Bernhard] Leiden Univ, Cognit Psychol Unit, NL-2333 AK Leiden, Netherlands.
RP Chabani, E (reprint author), Leiden Univ, Inst Psychol, Leiden, Netherlands.
EM echabani@gmail.com; hommel@fsw.leidenuniv.nl
RI Hommel, Bernhard /F-8173-2010
OI Hommel, Bernhard /0000-0003-4731-5125
CR Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   Ben-Itzchak E, 2007, RES DEV DISABIL, V28, P287, DOI 10.1016/j.ridd.2006.03.002
   Bernard-Opitz V, 2001, J AUTISM DEV DISORD, V31, P377, DOI 10.1023/A:1010660502130
   Blischak DM, 2003, TOP LANG DISORD, V23, P293
   Bolte S, 2006, BEHAV NEUROSCI, V120, P211, DOI 10.1037/0735-7044.120.1.211
   Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169
   Bosseler A, 2003, J AUTISM DEV DISORD, V33, P653, DOI 10.1023/B:JADD.0000006002.82367.4f
   Brian JA, 1996, J CHILD PSYCHOL PSYC, V37, P865, DOI 10.1111/j.1469-7610.1996.tb01482.x
   Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x
   Caron MJ, 2004, NEUROPSYCHOLOGIA, V42, P467, DOI 10.1016/j.neuropsychologia.2003.08.015
   Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
   Centers for Disease Control and Prevention, 2013, AUT SPECTR DIS ASDS
   Chabani E., 2013, FACE TO FACE V UNPUB
   Cherney ID, 2004, PERCEPT MOTOR SKILL, V98, P1269, DOI 10.2466/pms.98.3c.1269-1282
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, P145, DOI DOI 10.1097/00004703-200604002-00013
   Critchley H, 2000, HUM BRAIN MAPP, V9, P93, DOI 10.1002/(SICI)1097-0193(200002)9:2<93::AID-HBM4>3.0.CO;2-Z
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Dawson M., 2006, J AUTISM DEV DISORD, V36, P1573
   Dawson M., 2008, LEARNING MEMORY COMP, V2, P759
   Edgin JO, 2005, J AUTISM DEV DISORD, V35, P729, DOI 10.1007/s10803-005-0020-y
   Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8
   Farroni T, 2000, PERCEPTION, V29, P355
   Fitting S., 2003, INT J TESTING, V3, P293, DOI 10.1207/S15327574IJT0303_7
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Geiser C, 2006, MULTIVAR BEHAV RES, V41, P261, DOI 10.1207/s15327906mbr4103_2
   Golan Ofer, 2010, J Autism Dev Disord, V40, P269, DOI 10.1007/s10803-009-0862-9
   Golan O., 2006, DEV PSYCHOPATHOL, V18, P589
   Goodwin MS, 2008, FOCUS AUTISM DEV DIS, V23, P125, DOI 10.1177/1088357608316678
   Grinter EJ, 2010, J CHILD PSYCHOL PSYC, V51, P717, DOI 10.1111/j.1469-7610.2009.02203.x
   Gross TF, 2004, J ABNORM CHILD PSYCH, V32, P469, DOI 10.1023/B:JACP.0000037777.17698.01
   Perreault A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019519
   Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377
   Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Hayward DA, 2012, J AUTISM DEV DISORD, V42, P2383, DOI 10.1007/s10803-012-1485-0
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Hubl D, 2003, NEUROLOGY, V61, P1232
   Iarocci G, 2006, J AUTISM DEV DISORD, V36, P117, DOI 10.1007/s10803-005-0045-2
   Jarrold C, 2005, DEVELOPMENTAL SCI, V8, P344, DOI 10.1111/j.1467-7687.2005.00422.x
   Johnson SP, 2010, COGNITIVE SCI, V34, P1158, DOI 10.1111/j.1551-6709.2010.01127.x
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kim H., 2010, ENCY PERCEPTION, P496
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Koppenhaver DA, 2003, TOP LANG DISORD, V23, P283
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Koyama T, 2008, PSYCHIAT CLIN NEUROS, V62, P691, DOI 10.1111/j.1440-1819.2008.01871.x
   Landa R, 2007, MENT RETARD DEV D R, V13, P16, DOI 10.1002/mrdd.20134
   Lopez B, 2008, AUTISM, V12, P159, DOI 10.1177/1362361307086662
   Lopez B, 2003, J CHILD PSYCHOL PSYC, V44, P285, DOI 10.1111/1469-7610.00121
   Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
   Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
   McAlonan G. M., 2004, BRAIN, V128, P268, DOI 10.1093/brain/awh332
   Mitchell P, 2004, INFANT CHILD DEV, V13, P185, DOI 10.1002/icd.348
   Moore M, 2000, J AUTISM DEV DISORD, V30, P359, DOI 10.1023/A:1005535602064
   Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Nakano T, 2010, P R SOC B, V277, P1027, DOI 10.1098/rspb.2009.1713
   NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
   Newman MG, 2004, J CLIN PSYCHOL, V60, P141, DOI 10.1002/jclp.10240
   Ogletree B. T., 2007, FOCUS AUTISM OTHER D, V22, P190, DOI 10.1177/10883576070220030601
   O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219
   OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x
   Pellicano E, 2006, DEV PSYCHOPATHOL, V18, P77, DOI 10.1017/S0954579406060056
   Pennington RC, 2010, FOCUS AUTISM DEV DIS, V25, P239, DOI 10.1177/1088357610378291
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Plaisted K, 2003, PHILOS T ROY SOC B, V358, P375, DOI 10.1098/rstb.2002.1211
   Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P765, DOI 10.1017/S0021963098002601
   Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
   Poirel N, 2008, DEV PSYCHOL, V44, P245, DOI 10.1037/0012-1649.44.1.245
   Pring L, 2010, PERCEPTION, V39, P1094, DOI 10.1068/p6674
   Prizant B. M., 2006, SCERTS MODEL COMPREH, V1
   Quinn PC, 2002, PSYCHOL SCI, V13, P320, DOI 10.1111/1467-9280.00459
   Quinn PC, 2006, J EXP PSYCHOL HUMAN, V32, P1221, DOI 10.1037/0096-1523.32.5.1221
   Ramdoss S, 2011, RES AUTISM SPECT DIS, V5, P1306, DOI 10.1016/j.rasd.2011.03.004
   Rinehart NJ, 2000, J CHILD PSYCHOL PSYC, V41, P769, DOI 10.1017/S002196309900596X
   Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
   Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748
   Bolte S, 2004, FOCUS ON AUTISM RESEARCH, P247
   Scherf KS, 2008, AUTISM RES, V1, P114, DOI 10.1002/aur.17
   Schilling DL, 2004, J AUTISM DEV DISORD, V34, P423, DOI 10.1023/B:JADD.0000037418.48587.f4
   Schultz R. T., 2000, ARCH GEN PSYCHIAT, V57, P40
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Soulieres I., 2009, 8 ANN INT M AUT RES
   Stewart ME, 2009, AUTISM, V13, P133, DOI 10.1177/1362361308098515
   Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
   Travers JC, 2011, EDUC TRAIN AUTISM DE, V46, P326
   Uttal DH, 2013, PSYCHOL BULL, V139, P352, DOI 10.1037/a0028446
   Vandenbroucke MWG, 2008, J AUTISM DEV DISORD, V38, P941, DOI 10.1007/s10803-007-0467-0
   Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096
   Williams C, 2002, AUTISM, V6, P71, DOI 10.1177/1362361302006001006
   Wolfberg P. J., 2009, PLAY IMAGINATION CHI
NR 98
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2230
EP 2243
DI 10.1007/s10803-014-2107-9
PG 14
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400013
PM 24696376
ER

PT J
AU Laugeson, EA
   Ellingsen, R
   Sanderson, J
   Tucci, L
   Bates, S
AF Laugeson, Elizabeth A.
   Ellingsen, Ruth
   Sanderson, Jennifer
   Tucci, Lara
   Bates, Shannon
TI The ABC's of Teaching Social Skills to Adolescents with Autism Spectrum
   Disorder in the Classroom: The UCLA PEERS (R) Program
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social skills; Autism spectrum disorder; PEERS; Friendship; Adolescents;
   School
ID RANDOMIZED CONTROLLED-TRIAL; HIGH-FUNCTIONING AUTISM; INTERVENTION
   RESEARCH; SPECIAL-EDUCATION; CHILDREN; SCHOOL; STUDENTS; METAANALYSIS;
   FRIENDSHIPS; 1ST-GRADE
AB Social skills training is a common treatment method for adolescents with autism spectrum disorder (ASD), yet very few evidence-based interventions exist to improve social skills for high-functioning adolescents on the spectrum, and even fewer studies have examined the effectiveness of teaching social skills in the classroom. This study examines change in social functioning for adolescents with high-functioning ASD following the implementation of a school-based, teacher-facilitated social skills intervention known as Program for the Education and Enrichment of Relational Skills (PEERS (A (R)) ). Seventy-three middle school students with ASD along with their parents and teachers participated in the study. Participants were assigned to the PEERS (A (R)) treatment condition or an alternative social skills curriculum. Instruction was provided daily by classroom teachers and teacher aides for 14-weeks. Results reveal that in comparison to an active treatment control group, participants in the PEERS (A (R)) treatment group significantly improved in social functioning in the areas of teacher-reported social responsiveness, social communication, social motivation, social awareness, and decreased autistic mannerisms, with a trend toward improved social cognition on the Social Responsiveness Scale. Adolescent self-reports indicate significant improvement in social skills knowledge and frequency of hosted and invited get-togethers with friends, and parent-reports suggest a decrease in teen social anxiety on the Social Anxiety Scale at a trend level. This research represents one of the few teacher-facilitated treatment intervention studies demonstrating effectiveness in improving the social skills of adolescents with ASD in the classroom: arguably the most natural social setting of all.
C1 [Laugeson, Elizabeth A.; Ellingsen, Ruth; Tucci, Lara; Bates, Shannon] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
   [Laugeson, Elizabeth A.; Tucci, Lara] UCLA Autism Res Alliance, Help Grp, Sherman Oaks, CA 91401 USA.
   [Ellingsen, Ruth] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
   [Sanderson, Jennifer] Florida Atlantic Univ, Ctr Autism & Related Disabil, Boca Raton, FL 33431 USA.
RP Laugeson, EA (reprint author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, 760 Westwood Plaza,Ste 48-243B, Los Angeles, CA 90024 USA.
EM elaugeson@mednet.ucla.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
   Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Boardman AG, 2005, J SPEC EDUC, V39, P168, DOI 10.1177/00224669050390030401
   BUKOWSKI WM, 1994, J SOC PERS RELAT, V11, P471, DOI 10.1177/0265407594113011
   Chan JM, 2009, RES AUTISM SPECT DIS, V3, P876, DOI 10.1016/j.rasd.2009.04.003
   Chang Y. C., 2013, AUTISM INT J RES PRA, DOI [10. 1177/ 1362361313478995, DOI 10.1177/1362361313478995]
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Coucouvanis Judith, 2005, SUPER SKILLS SOCIAL
   Flynn L, 2012, RES AUTISM SPECT DIS, V6, P431, DOI 10.1016/j.rasd.2011.06.016
   Forness SR, 1998, BEHAV DISORDERS, V23, P111
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Frankel F, 2011, J CHILD FAM STUD, V20, P623, DOI 10.1007/s10826-010-9437-9
   Gantman A, 2012, J AUTISM DEV DISORD, V42, P1094, DOI 10.1007/s10803-011-1350-6
   Gresham F. M., 1990, SOCIAL SKILLS RATING
   Gresham FM, 2001, EXCEPT CHILDREN, V67, P331
   Harper CB, 2008, J AUTISM DEV DISORD, V38, P815, DOI 10.1007/s10803-007-0449-2
   Hart JE, 2011, INTERV SCH CLIN, V46, P273, DOI 10.1177/1053451210395382
   Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
   January AM, 2011, SCHOOL PSYCHOL REV, V40, P242
   KAMPS DM, 1992, J APPL BEHAV ANAL, V25, P281, DOI 10.1901/jaba.1992.25-281
   Kasari C, 2012, J CHILD PSYCHOL PSYC, V53, P431, DOI 10.1111/j.1469-7610.2011.02493.x
   La Greca AM, 1998, J ABNORM CHILD PSYCH, V26, P83, DOI 10.1023/A:1022684520514
   Lang R, 2011, RES AUTISM SPECT DIS, V5, P1296, DOI 10.1016/j.rasd.2011.02.012
   Lang R, 2011, INTERV SCH CLIN, V46, P230, DOI 10.1177/1053451210389031
   Lang R, 2010, EDUC TRAIN AUTISM DE, V45, P268
   Laugeson EA, 2014, J RATION-EMOT COGN-B, V32, P84, DOI 10.1007/s10942-014-0181-8
   Laugeson E. A., 2013, SCI MAKING FRIENDS H
   Laugeson E. A., 2014, PEERS CURRICULUM SCH
   Laugeson EA, 2011, SOCIAL SKILLS FOR TEENAGERS WITH DEVELOPMENTAL AND AUTISM SPECTRUM DISORDERS, P1
   Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5
   Laugeson EA, 2012, J AUTISM DEV DISORD, V42, P1025, DOI 10.1007/s10803-011-1339-1
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Licciardello C. C., 2008, ED TREATMENT CHILDRE, V31, P27, DOI DOI 10.1353/ETC.0.0010
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   Mandelberg J, 2014, J MENT HEALTH RES IN, V7, P45, DOI 10.1080/19315864.2012.730600
   Matson JL, 2007, BEHAV MODIF, V31, P682, DOI 10.1177/0145445507301650
   Moote GT, 1999, RES SOCIAL WORK PRAC, V9, P427
   Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
   Pierce K, 1997, J APPL BEHAV ANAL, V30, P157, DOI 10.1901/jaba.1997.30-157
   Piers E., 1984, PIERS HARRIS CHILDRE
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Redden S. C., 1999, J CHILD FAM STUD, V8, P285, DOI 10.1023/A:1022063228843
   Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
   Schohl K. A., 2013, J AUTISM DEV DISORD, V44, P1
   Sitlington P. L., 2007, ASSESSMENT EFFECTIVE, V32, P133, DOI DOI 10.1177/15345084070320030201
   Van Hecke AV, 2015, J AUTISM DEV DISORD, V45, P316, DOI 10.1007/s10803-013-1883-y
   Tantam D, 2003, CHILD ADOL PSYCH CL, V12, P143, DOI 10.1016/S1056-4993(02)00053-6
   White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Yoo HJ, 2014, AUTISM RES, V7, P145, DOI 10.1002/aur.1354
NR 52
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2244
EP 2256
DI 10.1007/s10803-014-2108-8
PG 13
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400014
PM 24715256
ER

PT J
AU Wood, JJ
   Fujii, C
   Renno, P
   Van Dyke, M
AF Wood, Jeffrey J.
   Fujii, Cori
   Renno, Patricia
   Van Dyke, Marilyn
TI Impact of Cognitive Behavioral Therapy on Observed Autism Symptom
   Severity During School Recess: A Preliminary Randomized, Controlled
   Trial
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Cognitive behavioral therapy; Autism spectrum disorders; School-aged
   children; School observations
ID HIGH-FUNCTIONING AUTISM; TREATING ANXIETY DISORDERS; LONG-TERM-MEMORY;
   SPECTRUM DISORDERS; ASPERGER-SYNDROME; SOCIAL-SKILLS; CLINICAL-TRIAL;
   CHILDREN; INTERVENTION; SERVICES
AB This study compared cognitive behavioral therapy (CBT) and treatment-as-usual (TAU) in terms of effects on observed social communication-related autism symptom severity during unstructured play time at school for children with autism spectrum disorders (ASD). Thirteen children with ASD (7-11 years old) were randomly assigned to 32 sessions of CBT or community-based psychosocial treatment (TAU) for 16 weeks. The CBT program is based on the memory retrieval competition model and emphasizes the development of perspective-taking through guided behavioral experimentation supplemented with reflective Socratic discussion and supported by parent training and school consultation to promote generalization of social communication and emotion regulation skills. Trained observers blind to treatment condition observed each child during recess on two separate days at baseline and again at posttreatment, using a structured behavioral observation system that generates frequency scores for observed social communication-related autism symptoms. CBT outperformed TAU at posttreatment on the frequency of self-isolation, the proportion of time spent with peers, the frequency of positive or appropriate interaction with peers, and the frequency of positive or appropriate peer responses to the target child (d effect size range 1.34-1.62). On average, children in CBT were engaged in positive or appropriate social interaction with peers in 68.6 % of observed intervals at posttreatment, compared to 25 % of intervals for children in TAU. Further investigation of this intervention modality with larger samples and follow-up assessments is warranted.
C1 [Wood, Jeffrey J.; Fujii, Cori; Renno, Patricia; Van Dyke, Marilyn] Univ Calif Los Angeles, Dept Educ, Los Angeles, CA 90095 USA.
   [Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA.
RP Wood, JJ (reprint author), Univ Calif Los Angeles, Dept Educ, Moore Hall,Box 951521, Los Angeles, CA 90095 USA.
EM jwood@gseis.ucla.edu
CR Akritas MG, 2003, RECENT ADVANCES AND TRENDS IN NONPARAMETRIC STATISTICS, P79, DOI 10.1016/B978-044451378-6/50006-5
   ANDERSON MC, 1994, J EXP PSYCHOL LEARN, V20, P1063, DOI 10.1037/0278-7393.20.5.1063
   Anderson MC, 2000, J EXP PSYCHOL LEARN, V26, P1141, DOI 10.1037/0278-7393.26.5.1141
   Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
   Bauminger N, 2002, J AUTISM DEV DISORD, V32, P283, DOI 10.1023/A:1016378718278
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Brewin CR, 2006, BEHAV RES THER, V44, P765, DOI 10.1016/j.brat.2006.02.005
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Chamberlain B, 2007, J AUTISM DEV DISORD, V37, P230, DOI 10.1007/s10803-006-0164-4
   Chambless DL, 1998, J CONSULT CLIN PSYCH, V66, P7, DOI 10.1037//0022-006X.66.1.7
   Chang YC, 2012, J DEV PHYS DISABIL, V24, P235, DOI 10.1007/s10882-012-9268-2
   Craske MG, 2008, BEHAV RES THER, V46, P5, DOI 10.1016/j.brat.2007.10.003
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   DeRosier ME, 2011, J AUTISM DEV DISORD, V41, P1033, DOI 10.1007/s10803-010-1128-2
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Ferraioli S. J., 2011, J CONTEMP PSYCHOTHER, V41, P19, DOI [10.1007/s10879-010-9156-y, DOI 10.1007/S10879-010-9156-Y]
   Fujii C, 2013, SCH MENT HEALTH, V5, P25, DOI 10.1007/s12310-012-9090-0
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
   Horwitz SM, 2001, PSYCHIATR SERV, V52, P1088, DOI 10.1176/appi.ps.52.8.1088
   Ingram DH, 2007, AUTISM, V11, P311, DOI 10.1177/1362361307078129
   Kasari C, 2012, J CHILD PSYCHOL PSYC, V53, P431, DOI 10.1111/j.1469-7610.2011.02493.x
   Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
   Kaufman A. S., 2004, KAUFMAN BRIEF INTELL
   Kendall PC, 1997, J CONSULT CLIN PSYCH, V65, P366, DOI 10.1037/0022-006X.65.3.366
   KENDALL PC, 1994, J CONSULT CLIN PSYCH, V62, P100, DOI 10.1037/0022-006X.62.1.100
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Lickel A, 2012, J AUTISM DEV DISORD, V42, P992, DOI 10.1007/s10803-011-1330-x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Loveland K. A., 2005, SCH AGE CHILD AUTIST, P247
   Marriage Samantha, 2009, J Can Acad Child Adolesc Psychiatry, V18, P322
   Matson JL, 2010, J DEV PHYS DISABIL, V22, P47, DOI 10.1007/s10882-009-9167-3
   Matson JL, 2010, J DEV PHYS DISABIL, V22, P331, DOI 10.1007/s10882-010-9188-y
   McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
   Puleo CM, 2011, J AUTISM DEV DISORD, V41, P275, DOI 10.1007/s10803-010-1047-2
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   Reichow B, 2009, J AUTISM DEV DISORD, V39, P23, DOI 10.1007/s10803-008-0596-0
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
   Spence SJ, 2010, LANCET, V375, P2124, DOI 10.1016/S0140-6736(10)60757-X
   Storch EA, 2013, J AM ACAD CHILD PSY, V52, P132, DOI 10.1016/j.jaac.2012.11.007
   Szatmari P, 2009, J CHILD PSYCHOL PSYC, V50, P1459, DOI 10.1111/j.1469-7610.2009.02123.x
   Thomas KC, 2007, J AUTISM DEV DISORD, V37, P818, DOI 10.1007/s10803-006-0208-9
   Tulving E., 1979, LEVELS PROCESSING HU, P405
   Walters SO, 2003, PSYCHOL REP, V92, P1111
   West L, 2009, J PEDIATR HEALTH CAR, V23, P75, DOI 10.1016/j.pedhc.2008.12.001
   Wood JJ, 2013, COGNITIVE BEHAVIOUR THERAPY FOR CHILDREN AND FAMILIES, 3RD EDITION, P189
   Wood J. J., 2008, CHILD ANXIETY DISORD
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JJ, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P197, DOI 10.1007/978-1-4419-6975-0_7
   Wood JJ, 2009, J AUTISM DEV DISORD, V39, P1608, DOI 10.1007/s10803-009-0791-7
NR 54
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2264
EP 2276
DI 10.1007/s10803-014-2097-7
PG 13
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400016
PM 24671750
ER

PT J
AU Pearson, A
   Marsh, L
   Hamilton, A
   Ropar, D
AF Pearson, Amy
   Marsh, Lauren
   Hamilton, Antonia
   Ropar, Danielle
TI Spatial Transformations of Bodies and Objects in Adults with Autism
   Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Spatial transformations; Bodies; Objects; Mental rotation; Egocentric;
   Autism
ID VISUAL PERSPECTIVE-TAKING; MENTAL ROTATION; BODY; CHILDREN; PERCEPTION;
   FMRI; SELF; MIND
AB Previous research into autism spectrum disorder (ASD) has shown people with autism to be impaired at visual perspective taking. However it is still unclear to what extent the spatial mechanisms underlying this ability contribute to these difficulties. In the current experiment we examine spatial transformations in adults with ASD and typical adults. Participants performed egocentric transformations and mental rotation of bodies and cars. Results indicated that participants with ASD had general perceptual differences impacting on response times across tasks. However, they also showed more specific differences in the egocentric task suggesting particular difficulty with using the self as a reference frame. These findings suggest that impaired perspective taking could be grounded in difficulty with the spatial transformation used to imagine the self in someone else's place.
C1 [Pearson, Amy; Marsh, Lauren; Hamilton, Antonia; Ropar, Danielle] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
RP Pearson, A (reprint author), Univ Durham, Dept Psychol, Sci Labs, South Rd, Durham DH1 3LE, England.
EM amy.pearson@durham.ac.uk
CR Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
   Brunye TT, 2012, PERS INDIV DIFFER, V52, P84, DOI 10.1016/j.paid.2011.09.004
   Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067
   Clements-Stephens AM, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00497
   Cornish KM, 1996, J AUTISM DEV DISORD, V26, P597, DOI 10.1007/BF02172349
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   David N, 2010, J AUTISM DEV DISORD, V40, P290, DOI 10.1007/s10803-009-0867-4
   Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8
   Frith CD, 2007, CURR BIOL, V17, pR724, DOI 10.1016/j.cub.2007.05.068
   Frith U, 2005, CONSCIOUS COGN, V14, P719, DOI 10.1016/j.concog.2005.04.006
   Frith U, 2012, Q J EXP PSYCHOL, V65, P2073, DOI 10.1080/17470218.2012.697178
   Hamilton AFD, 2009, COGNITION, V113, P37, DOI 10.1016/j.cognition.2009.07.007
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Hodzic A, 2009, NEUROIMAGE, V45, P1264, DOI 10.1016/j.neuroimage.2009.01.027
   Kessler K, 2012, COGN PROCESS, V13, pS21
   Kessler K., 2009, COGNITION, V114, P72, DOI DOI 10.1016/J.C0GNITI0N.2009.08.015
   Kosslyn SM, 1998, PSYCHOPHYSIOLOGY, V35, P151, DOI 10.1017/S0048577298001516
   Logothetis NK, 1996, ANNU REV NEUROSCI, V19, P577, DOI 10.1146/annurev.ne.19.030196.003045
   Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   Mazzarella E, 2012, Q J EXP PSYCHOL, V65, P2447, DOI 10.1080/17470218.2012.697905
   Michelon P, 2006, PERCEPT PSYCHOPHYS, V68, P327, DOI 10.3758/BF03193680
   PARSONS LM, 1987, J EXP PSYCHOL GEN, V116, P172, DOI 10.1037/0096-3445.116.2.172
   Pearson A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00652
   Reed CL, 2007, J AUTISM DEV DISORD, V37, P1576, DOI 10.1007/s10803-006-0220-0
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Schwabe L, 2009, HUM BRAIN MAPP, V30, P1801, DOI 10.1002/hbm.20764
   Senju A, 2012, NEUROSCIENTIST, V18, P108, DOI 10.1177/1073858410397208
   SHEPARD RN, 1971, SCIENCE, V171, P701, DOI 10.1126/science.171.3972.701
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   SOPER HV, 1986, J AUTISM DEV DISORD, V16, P155, DOI 10.1007/BF01531727
   Soulieres I, 2011, NEUROPSYCHOLOGIA, V49, P848, DOI 10.1016/j.neuropsychologia.2011.01.027
   Steggemann Y, 2011, BRAIN COGNITION, V76, P97, DOI 10.1016/j.bandc.2011.02.013
   Surtees A, 2013, COGNITION, V129, P426, DOI 10.1016/j.cognition.2013.06.008
   WECHSLER D, 1981, CONTEMP EDUC PSYCHOL, V6, P82, DOI 10.1016/0361-476X(81)90035-7
   Wexler M, 1998, COGNITION, V68, P77, DOI 10.1016/S0010-0277(98)00032-8
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Wraga M, 2003, BRAIN COGNITION, V52, P135, DOI 10.1016/S0278-2626(03)00033-2
   Wraga M, 2005, NEUROPSYCHOLOGIA, V43, P1351, DOI 10.1016/j.neuropsychologia.2004.11.028
   Yu AB, 2010, MEM COGNITION, V38, P982, DOI 10.3758/MC.38.7.982
   Zacks J, 1999, NEUROPSYCHOLOGIA, V37, P1029, DOI 10.1016/S0028-3932(99)00012-3
   Zacks JM, 2005, SPAT COGN COMPUT, V5, P271, DOI DOI 10.1207/S15427633SCC
   Zacks JM, 2000, SPAT COGN COMPUT, V2, P315, DOI DOI 10.1023/A:1015584100204
   Zacks JM, 2002, NEUROIMAGE, V16, P857, DOI 10.1006/nimg.2002.1129
NR 46
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2277
EP 2289
DI 10.1007/s10803-014-2098-6
PG 13
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400017
PM 24658868
ER

PT J
AU Morgan, L
   Leatzow, A
   Clark, S
   Siller, M
AF Morgan, Lindee
   Leatzow, Allison
   Clark, Sarah
   Siller, Michael
TI Interview Skills for Adults with Autism Spectrum Disorder: A Pilot
   Randomized Controlled Trial
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Autism; Adults; Randomized controlled trial; Social skills;
   Intervention
ID ADAPTIVE-BEHAVIOR SCALES; HIGH-FUNCTIONING AUTISM; QUALITY-OF-LIFE;
   SOCIAL-SKILLS; YOUNG-ADULTS; ASPERGERS SYNDROME; EMPLOYMENT; VINELAND;
   INDIVIDUALS; ADOLESCENTS
AB The purpose of this pilot study was to evaluate the efficacy of the interview skills curriculum (ISC), a manualized 12-week group-delivered intervention for young adults with autism spectrum disorder (ASD). This intervention aims to increase social-pragmatic skills essential to a successful job interview. Twenty-eight adults (18-36 years) were randomly assigned to one of two groups: ISC or waitlist control. Results revealed that the experimental group showed larger gains in social-pragmatic skills observed during a mock job interview than the control group. Treatment effects on distal outcomes, including social adaptive behaviors and depressive symptoms were not significant, although the respective effect sizes were medium/large. Results indicate that a brief, low-intensity treatment can improve the job-interview performance of young adults with ASD.
C1 [Morgan, Lindee; Leatzow, Allison; Clark, Sarah] Florida State Univ, Autism Inst, Tallahassee, FL 32301 USA.
   [Siller, Michael] CUNY Hunter Coll, New York, NY 10065 USA.
RP Morgan, L (reprint author), Florida State Univ, Autism Inst, 1940 N Monroe,Suite 72, Tallahassee, FL 32301 USA.
EM lindee.morgan@med.fsu.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barnard J, 2001, IGNORED INELIGIBLE R
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Centers for Autism and Related Disabilities, 2008, AD LIV SURV
   Centers for Disease Control and Prevention, 2012, SURVEILLANCE SUMMARI, V61, P1
   CHADSEYRUSCH J, 1992, AM J MENT RETARD, V96, P405
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Committee Interagency Autism Coordinating, 2012, STRAT PLAN AUT SPECT
   CORCORAN R, 1995, SCHIZOPHR RES, V17, P5, DOI 10.1016/0920-9964(95)00024-G
   Cotter M., 1997, THESIS U ALABAMA
   Duncan GJ, 2003, CHILD DEV, V74, P1454
   Fitzmaurice GM, 2004, APPL LONGITUDINAL AN
   Gantman A, 2012, J AUTISM DEV DISORD, V42, P1094, DOI 10.1007/s10803-011-1350-6
   Hillier A., 2007, FOCUS AUTISM OTHER D, V22, P107, DOI DOI 10.1177/10883576070220020201
   Howlin P., 1999, AUTISM, V3, P254
   Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
   Howlin P., 1999, AUTISM, V3, P299, DOI DOI 10.1177/1362361399003003007
   Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Lanier I., 2011, J CONTEMP PSYCHOTHER, V41, P37, DOI 10.1007/s10879-010-9160-2
   Laugeson EA, 2011, SOCIAL SKILLS FOR TEENAGERS WITH DEVELOPMENTAL AND AUTISM SPECTRUM DISORDERS, P1
   Laugeson EA, 2012, J AUTISM DEV DISORD, V42, P1025, DOI 10.1007/s10803-011-1339-1
   Liptak GS, 2011, J DEV BEHAV PEDIATR, V32, P277, DOI 10.1097/DBP.0b013e31820b49fc
   VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
   Lord C., 2012, AUTISM DIAGNOSTIC OB
   Lowe B, 2004, MED CARE, V42, P1194
   McGovern C., 2005, J CHILD PSYCHOL PSYC, V46, P409
   Mesibov G., 1985, J AUTISM DEV DISORD, V14, P395
   Morgan L., 2011, SOCIAL PRAGMAT UNPUB
   Newton J. H., 2008, PSYCHOL SCH, V5, P523
   Orsmond GI, 2013, J AUTISM DEV DISORD, V43, P2710, DOI 10.1007/s10803-013-1833-8
   OZONOFF S, 1995, J AUTISM DEV DISORD, V25, P415, DOI 10.1007/BF02179376
   Paul R, 2004, J AUTISM DEV DISORD, V34, P223, DOI 10.1023/B:JADD.0000022612.18116.46
   PERRY A, 1989, J AUTISM DEV DISORD, V19, P41, DOI 10.1007/BF02212717
   Provencal S. L., 2003, THESIS U UTAH
   Renty J, 2006, AUTISM, V10, P511, DOI 10.1177/1362361306066604
   Resnick B, 2005, NURS RES, V54, P139
   Roberts DL, 2004, SOCIAL COGNITI UNPUB
   Roid G. H., 2003, STANFORD BINET INTEL
   Roux AM, 2013, J AM ACAD CHILD PSY, V52, P931, DOI 10.1016/j.jaac.2013.05.019
   Shadish W, 2002, EXPT QUASIEXPERIMENT
   Shtayermman Oren, 2007, Issues Compr Pediatr Nurs, V30, P87, DOI 10.1080/01460860701525089
   Sigman M, 2005, J AUTISM DEV DISORD, V35, P15, DOI 10.1007/s10803-004-1027-5
   Sparrow S., 2004, VINELAND 2 ADAPTIVE
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Sterling L, 2008, J AUTISM DEV DISORD, V38, P1011, DOI 10.1007/s10803-007-0477-y
   SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
   Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
   Turner-Brown LM, 2008, J AUTISM DEV DISORD, V38, P1777, DOI 10.1007/s10803-008-0545-y
   Webb B. J., 2004, FOCUS AUTISM OTHER D, V19, P53, DOI DOI 10.1177/10883576040190010701
   Whitehouse AJO, 2009, J ADOLESCENCE, V32, P309, DOI 10.1016/j.adolescence.2008.03.004
   Williams White Susan, 2007, J Autism Dev Disord, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 54
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2290
EP 2300
DI 10.1007/s10803-014-2100-3
PG 11
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400018
PM 24682707
ER

PT J
AU Nah, YH
   Young, RL
   Brewer, N
AF Nah, Yong-Hwee
   Young, Robyn L.
   Brewer, Neil
TI Using the Autism Detection in Early Childhood (ADEC) and Childhood
   Autism Rating Scales (CARS) to Predict Long Term Outcomes in Children
   with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Predictive validity; ADEC; CARS; Long term
   outcomes
ID DIAGNOSTIC OBSERVATION SCHEDULE; BEHAVIOR CHECKLIST; VALIDITY; STAT; AGE
AB This study evaluated the predictive validity of the Autism Detection in Early Childhood (ADEC; Young, Autism detection in early childhood: ADEC. Australian Council of Educational Research, Camberwell, VIC 2007) and a well-established screening tool, the Childhood Autism Rating Scale (CARS; Schopler et al. The childhood autism rating scale (CARS). Western Psychological Services, Los Angeles 1988), for long term outcomes of children with ASD engaged in an early intervention program. Participants were 55 children (44 male, 11 female) aged 19-42 months (M = 33.5, SD = 5.6) at initial assessment who were followed up 2 and 6 years after their initial assessment. The ADEC and the CARS performed similarly when predicting long term outcomes such as clinical diagnostic outcome and overall adaptive functioning level. However, only the ADEC score was significantly correlated with ASD symptom severity at the 6-year follow up. Although these findings need to be replicated with additional and larger samples, this study extends our understanding of the psychometric properties of both the ADEC and the CARS.
C1 [Nah, Yong-Hwee; Young, Robyn L.; Brewer, Neil] Flinders Univ S Australia, Sch Psychol, Adelaide, SA 5001, Australia.
RP Nah, YH (reprint author), Flinders Univ S Australia, Sch Psychol, POB 2100, Adelaide, SA 5001, Australia.
EM yonghwee.nah@flinders.edu.au
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   American Psychiatric Association, 2000, DSM4TR AM PSYCH ASS
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
   Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
   DILALLA DL, 1994, J AUTISM DEV DISORD, V24, P115, DOI 10.1007/BF02172092
   Douglas K. S., 2008, HCR 20 VIOLENCE RISK
   EAVES RC, 1993, J ABNORM CHILD PSYCH, V21, P481, DOI 10.1007/BF00916315
   Feldman MA, 2012, J AUTISM DEV DISORD, V42, P13, DOI 10.1007/s10803-011-1208-y
   Filipek PA, 2000, NEUROLOGY, V55, P468
   Geier DA, 2013, J MENT HEALTH RES IN, V6, P255, DOI 10.1080/19315864.2012.681340
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Matson J. L., 2007, BABY INFANT SCREEN C
   Matson JL, 2011, J AUTISM DEV DISORD, V41, P1139, DOI 10.1007/s10803-010-0973-3
   Menard S, 1995, SAGE U PAPER SERIES, P7
   Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018
   Myers R, 1990, CLASSICAL MODERN REG, V2nd
   Nah YH, 2014, PSYCHOL ASSESSMENT, V26, P215, DOI 10.1037/a0034472
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P689, DOI 10.1007/s10803-009-0915-0
   Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466
   Rellini E, 2004, J AUTISM DEV DISORD, V34, P703, DOI 10.1007/s10803-004-5290-2
   Rust J.O., 2004, J PSYCHOEDUCATIONAL, V22, P367, DOI 10.1177/073428290402200407
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schalock R., 2007, USERS GUIDE MENTAL R
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Stone WL, 2004, J AUTISM DEV DISORD, V34, P691, DOI 10.1007/s10803-004-5289-8
   Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002
   Tachimori H, 2003, PSYCHIAT CLIN NEUROS, V57, P113, DOI 10.1046/j.1440-1819.2003.01087.x
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Young R., 2007, AUTISM DETECTION EAR
   Young R. L., 2009, STRUCTURED PROGRAM E
NR 41
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2301
EP 2310
DI 10.1007/s10803-014-2102-1
PG 10
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400019
PM 24658894
ER

PT J
AU Crais, ER
   McComish, CS
   Humphreys, BP
   Watson, LR
   Baranek, GT
   Reznick, JS
   Christian, RB
   Earls, M
AF Crais, Elizabeth R.
   McComish, Cara S.
   Humphreys, Betsy P.
   Watson, Linda R.
   Baranek, Grace T.
   Reznick, J. Steven
   Christian, Rob B.
   Earls, Marian
TI Pediatric Healthcare Professionals' Views on Autism Spectrum Disorder
   Screening at 12-18 Months
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder (ASD); Screening; Infants; Pediatric healthcare
   professionals
ID FOLLOW-UP; MODIFIED CHECKLIST; EARLY-DIAGNOSIS; YOUNG-CHILDREN; AGE;
   IDENTIFICATION; TODDLERS; INTERVENTIONS; SURVEILLANCE; INFANTS
AB This study explored North Carolina pediatric healthcare professional's (PHP) perceptions of screening 12-18 month old infants for Autism Spectrum Disorder (ASD). Eight focus groups (66 PHPs) were conducted across practice settings. The purpose was to explore PHP's perspectives to: inform development of ASD screening tools and ultimately impact their use in PHP settings. PHPs reported concerns, barriers, and the need for research to support early ASD screening. Additionally, they expressed the need for: (a) clear "red flags" of ASD for 12-18 month olds; (b) socioculturally sensitive and effective screening tools; (c) effective early interventions; (d) systems to handle potential increases in referrals; and (e) continuing education. PHPs also demonstrated preferences about screening tool characteristics and processes for enhancing screening efforts.
C1 [Crais, Elizabeth R.; McComish, Cara S.; Watson, Linda R.] Univ N Carolina, Div Speech & Hearing Sci, Chapel Hill, NC 27599 USA.
   [Humphreys, Betsy P.] Univ New Hampshires Inst Disabil, Durham, NH USA.
   [Baranek, Grace T.] Univ N Carolina, Div Occupat Sci & Occupat Therapy, Chapel Hill, NC 27599 USA.
   [Reznick, J. Steven] Univ N Carolina, Chapel Hill, NC 27599 USA.
   [Christian, Rob B.] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
   [Earls, Marian] Triad Adult & Pediat Med, Highpoint, NC USA.
RP Crais, ER (reprint author), Univ N Carolina, Div Speech & Hearing Sci, CB 7190,3126 Bondurant Hall, Chapel Hill, NC 27599 USA.
EM bcrais@med.unc.edu; gbaranek@med.unc.edu
CR Al-Qabandi M., 2011, PEDIATRICS, V128, P1
   Arunyanart W, 2012, INFANT YOUNG CHILD, V25, P175, DOI 10.1097/IYC.0b013e31825a5a42
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Baranek GT, 2003, 1 YEAR INVENTORY FYI
   Barbaro J, 2009, J DEV BEHAV PEDIATR, V30, P447, DOI 10.1097/DBP.0b013e3181ba0f9f
   Barton M., 2011, J AUTISM DEV DISORD, V42, P1165
   Braun Kim Van Naarden, 2007, Morbidity and Mortality Weekly Report, V56, P29
   Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
   Carbone PS, 2010, J AUTISM DEV DISORD, V40, P317, DOI 10.1007/s10803-009-0874-5
   Centers for Disease Control and Prevention, 2012, MMWR, V61
   Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
   Colgan SE, 2006, CHILD NEUROPSYCHOL, V12, P307, DOI 10.1080/09297040600701360
   Crais ER, 2006, AM J SPEECH-LANG PAT, V15, P365, DOI 10.1044/1058-0360(2006/034)
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dosreis S, 2006, J DEV BEHAV PEDIATR, V27, pS88, DOI 10.1097/00004703-200604002-00006
   Earls MF, 2006, PEDIATRICS, V118, pE183, DOI 10.1542/peds.2006-0475
   Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003
   Faggiolani C., 2011, ITALIAN J LIB SCI IN, V2
   Foy Jane Meschan, 2010, Pediatrics, V125 Suppl 3, pS87, DOI 10.1542/peds.2010-0788E
   Foy Jane Meschan, 2010, Pediatrics, V125 Suppl 3, pS75, DOI 10.1542/peds.2010-0788D
   Freuler A., 2013, AUTISM INT J RES PRA, DOI [10.1177/1362361313483928, DOI 10.1177/1362361313483928]
   Gillis JM, 2009, INFANT YOUNG CHILD, V22, P321
   Golnik A, 2009, PEDIATRICS, V123, P966, DOI 10.1542/peds.2008-1321
   Gupta VB, 2007, PEDIATRICS, V119, P152, DOI 10.1542/peds.2006-2026
   Gura GF, 2011, J DEV BEHAV PEDIATR, V32, P48, DOI 10.1097/DBP.0b013e3182040aea
   Guthrie W, 2013, J CHILD PSYCHOL PSYC, V54, P582, DOI 10.1111/jcpp.12008
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
   King TM, 2010, PEDIATRICS, V125, P350, DOI 10.1542/peds.2009-0388
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
   Krueger R. A., 2008, FOCUS GROUPS PRACTIC
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Mandell DS, 2010, PSYCHIAT SERV, V61, P822, DOI 10.1176/appi.ps.61.8.822
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   Mandell DS, 2007, J AUTISM DEV DISORD, V37, P1795, DOI 10.1007/s10803-006-0314-8
   Miller JS, 2011, PEDIATRICS, V127, P866, DOI 10.1542/peds.2010-0136
   Nassar-McMillan S. C., 2002, QUALITATIVE REPORT, V7
   Niehus R, 2006, J DEV BEHAV PEDIATR, V27, pS120, DOI 10.1097/00004703-200604002-00010
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
   Pinto-Martin Jennifer A, 2005, J Pediatr Nurs, V20, P163, DOI 10.1016/j.pedn.2005.01.004
   Remington B, 2007, AM J MENT RETARD, V112, P418, DOI 10.1352/0895-8017(2007)112[418:EIBIOF]2.0.CO;2
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
   Sand N, 2005, PEDIATRICS, V116, P174, DOI 10.1542/peds.2004-1809
   Sansosti FJ, 2012, FOCUS AUTISM DEV DIS, V27, P81, DOI 10.1177/1088357612446860
   Scientific Software Development, 2009, ATLAS TI VERS 6 2
   Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
   Strauss A., 1990, BASICS QUALITATIVE R
   Turner-Brown LM, 2013, AUTISM, V17, P527, DOI 10.1177/1362361312439633
   Van Cleave J, 2012, ACAD PEDIATR, V12, P269, DOI 10.1016/j.acap.2012.02.004
   Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159
   Watson LR, 2013, AM J SPEECH-LANG PAT, V22, P25, DOI 10.1044/1058-0360(2012/11-0145)
   Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6
   Wetherby AM, 2008, AUTISM, V12, P487, DOI 10.1177/1362361308094501
   Wetherby AM, 2002, COMMUNICATION SYMBOL
   Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
   Wise MD, 2010, J DEV BEHAV PEDIATR, V31, P469, DOI 10.1097/DBP.0b013e3181e56db2
   Zuckerman KE, 2013, PEDIATRICS, V132, P445, DOI 10.1542/peds.2013-0383
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 64
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2311
EP 2328
DI 10.1007/s10803-014-2101-2
PG 18
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400020
PM 24700359
ER

PT J
AU Kassardjian, A
   Leaf, JB
   Ravid, D
   Leaf, JA
   Alcalay, A
   Dale, S
   Tsuji, K
   Taubman, M
   Leaf, R
   McEachin, J
   Oppenheim-Leaf, ML
AF Kassardjian, Alyne
   Leaf, Justin B.
   Ravid, Daniel
   Leaf, Jeremy A.
   Alcalay, Aditt
   Dale, Stephanie
   Tsuji, Kathleen
   Taubman, Mitchell
   Leaf, Ronald
   McEachin, John
   Oppenheim-Leaf, Misty L.
TI Comparing the Teaching Interaction Procedure to Social Stories: A
   Replication Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Behavioral skills training; Social skills; Social skills groups;
   Social stories; Teaching interaction procedure
ID ASPERGER-SYNDROME; AUTISM; CHILDREN; SKILLS; COMMUNICATION; DISORDER;
   INCREASE; BEHAVIOR
AB This study compared the teaching interaction procedure to social stories implemented in a group setting to teach social skills to three children diagnosed with autism spectrum disorder. The researchers taught each participant one social skill with the teaching interaction procedure, one social skill with the social story procedure, and one social skill was assigned to a no intervention condition. The teaching interaction procedure consisted of didactic questions, teacher demonstration, and role-play; the social story procedure consisted of reading a book and answering comprehension questions. The researchers measured participants' performances during probes, responses to comprehension questions, and responding during role-plays. The results indicated that the teaching interaction procedure was more efficacious than the social story procedure across all three participants.
C1 [Kassardjian, Alyne; Leaf, Justin B.; Ravid, Daniel; Leaf, Jeremy A.; Alcalay, Aditt; Dale, Stephanie; Tsuji, Kathleen; Taubman, Mitchell; Leaf, Ronald; McEachin, John; Oppenheim-Leaf, Misty L.] Autism Partnership Fdn, Seal Beach, CA 90740 USA.
RP Leaf, JB (reprint author), Autism Partnership Fdn, 200 Marina Dr, Seal Beach, CA 90740 USA.
EM jblautpar@aol.com
CR Adams L., 2004, FOCUS AUTISM OTHER D, V19, P87, DOI DOI 10.1177/10883576040190020301
   [Anonymous], 2009, NAT STAND PROJ ADDR
   Ayllon T., 1968, TOKEN EC MOTIVATIONA
   BAER DM, 1968, J APPL BEHAV ANAL, V1, P91, DOI 10.1901/jaba.1968.1-91
   Barry L. M., 2004, FOCUS AUTISM OTHER D, V19, P45, DOI DOI 10.1177/10883576040190010601
   Barry TD, 2003, J AUTISM DEV DISORD, V33, P685, DOI 10.1023/B:JADD.0000006004.86556.e0
   Bledsoe R, 2003, AUTISM, V7, P289, DOI 10.1177/1362361303007003005
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Delano M, 2006, J POSIT BEHAV INTERV, V8, P29, DOI 10.1177/10983007060080010501
   Dotson WH, 2010, RES AUTISM SPECT DIS, V4, P199, DOI 10.1016/j.rasd.2009.09.005
   Gray C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1, DOI DOI 10.1177/108835769300800101
   Kassardjian A, 2013, EDUC TRAIN AUTISM DE, V48, P245
   Kokina A, 2010, J AUTISM DEV DISORD, V40, P812, DOI 10.1007/s10803-009-0931-0
   KRANTZ PJ, 1993, J APPL BEHAV ANAL, V26, P121, DOI 10.1901/jaba.1993.26-121
   Ladd GW, 1999, CHILD DEV, V70, P1373, DOI 10.1111/1467-8624.00101
   Leaf JB, 2012, J APPL BEHAV ANAL, V45, P281, DOI 10.1901/jaba.2012.45-281
   Leaf JB, 2010, RES AUTISM SPECT DIS, V4, P186, DOI 10.1016/j.rasd.2009.09.003
   Leaf JB, 2009, RES AUTISM SPECT DIS, V3, P275, DOI 10.1016/j.rasd.2008.07.003
   Lovaas O. I., 1981, TEACHING DEV DISABLE
   Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P109, DOI 10.1016/j.rasd.2012.07.009
   Oppenheim-Leaf ML, 2012, J DEV PHYS DISABIL, V24, P347, DOI 10.1007/s10882-012-9274-4
   Phillips E. L., 1974, TEACHING FAMILY HDB
   PHILLIPS EL, 1971, J APPL BEHAV ANAL, V4, P45, DOI 10.1901/jaba.1971.4-45
   Pierson MR, 2007, EDUC TRAIN DEV DISAB, V42, P460
   Reynhout G, 2009, RES AUTISM SPECT DIS, V3, P232, DOI 10.1016/j.rasd.2008.06.003
   Sansosti FJ, 2008, J POSIT BEHAV INTERV, V10, P162, DOI 10.1177/1098300708316259
   Scattone D, 2008, J AUTISM DEV DISORD, V38, P395, DOI 10.1007/s10803-007-0392-2
   Soluaga D, 2008, RES AUTISM SPECT DIS, V2, P753, DOI 10.1016/j.rasd.2008.03.005
   STAHMER AC, 1995, J AUTISM DEV DISORD, V25, P123, DOI 10.1007/BF02178500
   Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
   Thiemann KS, 2001, J APPL BEHAV ANAL, V34, P425, DOI 10.1901/jaba.2001.34-425
NR 31
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2329
EP 2340
DI 10.1007/s10803-014-2103-0
PG 12
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400021
PM 24682708
ER

PT J
AU Kimhi, Y
   Shoam-Kugelmas, D
   Ben-Artzi, GA
   Ben-Moshe, I
   Bauminger-Zviely, N
AF Kimhi, Yael
   Shoam-Kugelmas, Dana
   Ben-Artzi, Galit Agam
   Ben-Moshe, Inbal
   Bauminger-Zviely, Nirit
TI Theory of Mind and Executive Function in Preschoolers with Typical
   Development Versus Intellectually Able Preschoolers with Autism Spectrum
   Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Theory of mind; Executive functions; Preschool
ID FALSE BELIEF; INHIBITORY CONTROL; INDIVIDUAL-DIFFERENCES; FUNCTION
   DEFICITS; YOUNG-CHILDREN; DYSFUNCTION; LANGUAGE; ABILITY; DESIRES;
   IMPAIRMENTS
AB Children with autism spectrum disorder (ASD) have difficulties in theory of mind (ToM) and executive function (EF), which may be linked because one domain (EF) affects the other (ToM). Group differences (ASD vs. typical development) were examined in both cognitive domains, as well as EF's associations and regressions with ToM. Participants included 29 intellectually able preschoolers with ASD and 30 typical preschoolers, aged 3-6 years. EF tasks included planning and cognitive shifting measures. ToM tasks included predicting and explaining affective and location false-belief tasks. The novelty of this study lies in its in-depth examination of ToM explanation abilities in ASD alongside the role of verbal abilities (VIQ). Significant group differences emerged on most EF and ToM measures, in favor of typically developing children. Overall in the study group, EF-planning skills, EF-cognitive shifting and VIQ significantly contributed to the explained variance of ToM measures. Implications are discussed regarding the social-cognitive deficit in ASD.
C1 [Kimhi, Yael; Shoam-Kugelmas, Dana; Ben-Artzi, Galit Agam; Ben-Moshe, Inbal; Bauminger-Zviely, Nirit] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
   [Kimhi, Yael] Levinsky Coll Educ, Tel Aviv, Israel.
RP Bauminger-Zviely, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM nirit.bauminger@biu.ac.il
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Atance CM, 2010, DEV PSYCHOL, V46, P1505, DOI 10.1037/a0020374
   BARTSCH K, 1989, CHILD DEV, V60, P946, DOI 10.1111/j.1467-8624.1989.tb03526.x
   Biro S, 2001, DEV PSYCHOPATHOL, V13, P97, DOI 10.1017/S0954579401001079
   CAPPS L, 1995, DEV PSYCHOPATHOL, V7, P137
   Carlson SM, 2004, J EXP CHILD PSYCHOL, V87, P299, DOI 10.1016/j.jecp.2004.01.002
   Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
   Colle L, 2007, J AUTISM DEV DISORD, V37, P716, DOI 10.1007/s10803-006-0198-7
   Colonnesi C, 2008, INFANT CHILD DEV, V17, P163, DOI 10.1002/icd.548
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   Dawson G., 1998, CHILD DEV, V69, P1277
   Fisher N, 2005, J AUTISM DEV DISORD, V35, P757, DOI 10.1007/s10803-005-0022-9
   Flynn E, 2004, DEVELOPMENTAL SCI, V7, P103, DOI 10.1111/j.1467-7687.2004.00326.x
   Flynn E, 2007, INFANT CHILD DEV, V16, P53, DOI 10.1002/icd.500
   Frye D., 2000, CHILDRENS REASONING, P149
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
   Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
   Griffith EM, 1999, CHILD DEV, V70, P817, DOI 10.1111/1467-8624.00059
   Harris P., 1989, COGNITION EMOTION, V3, P379, DOI DOI 10.1080/02699938908412713
   Harris PL, 1989, CHILDREN EMOTION DEV
   Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Hughes C, 1996, J CHILD PSYCHOL PSYC, V37, P229, DOI 10.1111/j.1469-7610.1996.tb01396.x
   Hughes C, 1998, BRIT J DEV PSYCHOL, V16, P233
   Hughes C., 2002, CHILD ADOLESCENT MEN, V7, P131, DOI DOI 10.1111/1475-3588.00024
   Hughes C, 2007, DEV PSYCHOL, V43, P1447, DOI 10.1037/0012-1649.43.6.1447
   Isquith PK, 2005, MENT RETARD DEV D R, V11, P209, DOI 10.1002/mrdd.20075
   Jacques S, 2001, DEV NEUROPSYCHOL, V20, P573, DOI 10.1207/875656401753549807
   Joseph RM, 2005, DEV NEUROPSYCHOL, V27, P361, DOI 10.1207/s15326942dn2703_4
   Kissine M, 2012, MIND LANG, V27, P1, DOI 10.1111/j.1468-0017.2011.01433.x
   Kleinhans N, 2005, DEV NEUROPSYCHOL, V27, P379, DOI 10.1207/s15326942dn2703_5
   Landa RJ, 2005, J AUTISM DEV DISORD, V35, P557, DOI 10.1007/s10803-005-0001-1
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   McAlister A, 2006, BRIT J DEV PSYCHOL, V24, P733, DOI 10.1348/026151005X70094
   Mullen E, 1995, MULLEN SCALES EARLY
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
   Parker JR, 2007, J GENET PSYCHOL, V168, P43, DOI 10.3200/GNTP.168.1.43-62
   Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287
   Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Perner J, 2002, CHILD DEV, V73, P752, DOI 10.1111/1467-8624.00436
   Peterson CC, 2005, J AUTISM DEV DISORD, V35, P487, DOI 10.1007/s10803-005-5039-6
   Rieffe C, 2001, BRIT J DEV PSYCHOL, V19, P259, DOI 10.1348/026151001166065
   Rieffe C, 2000, J AUTISM DEV DISORD, V30, P195, DOI 10.1023/A:1005540417877
   Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
   Russell J, 2001, J CHILD PSYCHOL PSYC, V42, P317, DOI 10.1017/S0021963001006874
   Russell J., 1996, AUTISM EXECUTIVE DIS, P256
   Rutherford MD, 2003, J AUTISM DEV DISORD, V33, P289, DOI 10.1023/A:1024406601334
   Sabbagh MA, 2006, CHILD DEV, V77, P1034, DOI 10.1111/j.1467-8624.2006.00917.x
   SHALLICE T, 1982, PHILOS T ROY SOC B, V298, P199, DOI 10.1098/rstb.1982.0082
   Shu BC, 2001, AUTISM, V5, P165, DOI 10.1177/1362361301005002006
   Slaughter V, 2007, CHILD DEV, V78, P839, DOI 10.1111/j.1467-8624.2007.01036.x
   Steele S, 2003, J AUTISM DEV DISORD, V33, P461, DOI 10.1023/A:1025075115100
   TAGERFLUSBERG H, 1994, J CHILD PSYCHOL PSYC, V35, P1059, DOI 10.1111/j.1469-7610.1994.tb01809.x
   Verte S, 2005, DEV PSYCHOPATHOL, V17, P415, DOI 10.1017/S0954579405050200
   Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
   Wechsler D., 1998, WECHSLER SCALES INTE
   Wellman HM, 2004, CHILD DEV, V75, P523, DOI 10.1111/j.1467-8624.2004.00691.x
   White SJ, 2009, AUTISM RES, V2, P138, DOI 10.1002/aur.78
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
   Yerys BE, 2009, AUTISM, V13, P523, DOI 10.1177/1362361309335716
   Yerys BE, 2007, J AUTISM DEV DISORD, V37, P1068, DOI 10.1007/s10803-006-0250-7
   Zelazo PD, 2004, ACTA PSYCHOL, V115, P167, DOI 10.1016/j.actpsy.2003.12.005
   Zelazo PD, 2002, INFANT CHILD DEV, V11, P171, DOI 10.1002/icd.304
NR 65
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2341
EP 2354
DI 10.1007/s10803-014-2104-z
PG 14
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400022
PM 24696374
ER

PT J
AU Bowler, DM
   Gaigg, SB
   Gardiner, JM
AF Bowler, Dermot M.
   Gaigg, Sebastian B.
   Gardiner, John M.
TI Binding of Multiple Features in Memory by High-Functioning Adults with
   Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Memory; Relational binding
ID EPISODIC FUTURE THINKING; ASPERGERS-SYNDROME; RECALL; RECOGNITION;
   DEFICITS; CHILDREN; CONTEXT; BRAIN
AB Diminished episodic memory and diminished use of semantic information to aid recall by individuals with autism spectrum disorder (ASD) are both thought to result from diminished relational binding of elements of complex stimuli. To test this hypothesis, we asked high-functioning adults with ASD and typical comparison participants to study grids in which some cells contained drawings of objects in non-canonical colours. Participants were told at study which features (colour, item, location) would be tested in a later memory test. In a second experiment, participants studied similar grids and were told that they would be tested on object-location or object-colour combinations. Recognition of combinations was significantly diminished in ASD, which survived covarying performance on the Color Trails Test (D'Elia et al. Color trails test. Professional manual. Psychological Assessment Resources, Lutz, 1996), a test of executive difficulties. The findings raise the possibility that medial temporal as well as frontal lobe processes are dysfunctional in ASD.
C1 [Bowler, Dermot M.; Gaigg, Sebastian B.; Gardiner, John M.] City Univ London, Dept Psychol, Autism Res Grp, London EC1V 0HB, England.
RP Bowler, DM (reprint author), City Univ London, Dept Psychol, Autism Res Grp, Northampton Sq, London EC1V 0HB, England.
EM d.m.bowler@city.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   BAUMAN M, 1985, NEUROLOGY, V35, P866
   Boucher J, 2012, PSYCHOL BULL, V138, P458, DOI 10.1037/a0026869
   Bowler D, 2007, AUTISM SPECTRUM DISO
   Bowler D. M., 2008, MEMORY AUTISM, P330, DOI DOI 10.1017/CBO9780511490101
   Bowler DA, 2008, NEUROPSYCHOLOGIA, V46, P993, DOI 10.1016/j.neuropsychologia.2007.12.004
   Bowler DM, 2007, CONSCIOUS COGN, V16, P124, DOI 10.1016/j.concog.2005.12.001
   Bowler DM, 2004, J AUTISM DEV DISORD, V34, P533, DOI 10.1007/s10803-004-2548-7
   Bowler DM, 2008, J AUTISM DEV DISORD, V38, P104, DOI 10.1007/s10803-007-0366-4
   Bowler DM, 1997, NEUROPSYCHOLOGIA, V35, P65, DOI 10.1016/S0028-3932(96)00054-1
   Brown MW, 2001, NAT REV NEUROSCI, V2, P51, DOI 10.1038/35049064
   Chalfonte BL, 1996, MEM COGNITION, V24, P403, DOI 10.3758/BF03200930
   Craik FIM, 1999, ATTENTION PERFORM, V17, P583
   DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777
   D'Elia LF, 1996, COLOR TRAILS TEST PR
   Bowler DM, 2000, J AUTISM DEV DISORD, V30, P305, DOI 10.1023/A:1005552811441
   Goldstein G., 2008, MEMORY AUTISM THEORY, P125, DOI 10.1017/CBO9780511490101.009
   Happe F, 2012, GERONTOLOGY, V58, P70, DOI 10.1159/000329720
   Ishihara S., 1999, ISHIHARAS TESTS COLO
   Klin A., 2000, ASPERGER SYNDROME
   Lind SE, 2010, J ABNORM PSYCHOL, V119, P896, DOI 10.1037/a0020631
   Lind SE, 2014, NEUROPSYCHOLOGY, V28, P55, DOI 10.1037/neu0000005
   Lopez B, 2003, J CHILD PSYCHOL PSYC, V44, P285, DOI 10.1111/1469-7610.00121
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Minshew N. J., 1993, NEUROPSYCHOLOGY, V7, P209, DOI DOI 10.1037/0894-4105.7.2.209
   MINSHEW NJ, 1992, J CLIN EXP NEUROPSYC, V14, P749, DOI 10.1080/01688639208402860
   Minshew NJ, 2001, J CHILD PSYCHOL PSYC, V42, P1095, DOI 10.1111/1469-7610.00808
   Mukaetova-Ladinska EB, 2012, INT J GERIATR PSYCH, V27, P109, DOI 10.1002/gps.2711
   Nicolson R, 2006, PSYCHIAT RES-NEUROIM, V148, P11, DOI 10.1016/j.pscychresns.2006.02.005
   Shimamura AP, 2010, HIPPOCAMPUS, V20, P1206, DOI 10.1002/hipo.20856
   Smith BJ, 2007, J AUTISM DEV DISORD, V37, P445, DOI 10.1007/s10803-006-0180-4
   SNODGRASS JG, 1980, J EXP PSYCHOL-HUM L, V6, P174, DOI 10.1037/0278-7393.6.2.174
   Squire LR, 2004, NEUROBIOL LEARN MEM, V82, P171, DOI 10.1016/j.nlm.2004.06.005
   Tulving E, 2001, PHILOS T ROY SOC B, V356, P1505, DOI 10.1098/rstb.2001.0937
   Zimmer H. D., 2006, HDB BINDING MEMORY P
NR 35
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2355
EP 2362
DI 10.1007/s10803-014-2105-y
PG 8
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400023
PM 24696375
ER

PT J
AU Fink, E
   de Rosnay, M
   Wierda, M
   Koot, HM
   Begeer, S
AF Fink, Elian
   de Rosnay, Marc
   Wierda, Marlies
   Koot, Hans M.
   Begeer, Sander
TI Brief Report: Accuracy and Response Time for the Recognition of Facial
   Emotions in a Large Sample of Children with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Emotion recognition; Emotion processing;
   Social communication
ID INDIVIDUALS; ADOLESCENTS; DEFICITS
AB The empirical literature has presented inconsistent evidence for deficits in the recognition of basic emotion expressions in children with autism spectrum disorders (ASD), which may be due to the focus on research with relatively small sample sizes. Additionally, it is proposed that although children with ASD may correctly identify emotion expression they rely on more deliberate, more time-consuming strategies in order to accurately recognize emotion expressions when compared to typically developing children. In the current study, we examine both emotion recognition accuracy and response time in a large sample of children, and explore the moderating influence of verbal ability on these findings. The sample consisted of 86 children with ASD (M (age) = 10.65) and 114 typically developing children (M (age) = 10.32) between 7 and 13 years of age. All children completed a pre-test (emotion word-word matching), and test phase consisting of basic emotion recognition, whereby they were required to match a target emotion expression to the correct emotion word; accuracy and response time were recorded. Verbal IQ was controlled for in the analyses. We found no evidence of a systematic deficit in emotion recognition accuracy or response time for children with ASD, controlling for verbal ability. However, when controlling for children's accuracy in word-word matching, children with ASD had significantly lower emotion recognition accuracy when compared to typically developing children. The findings suggest that the social impairments observed in children with ASD are not the result of marked deficits in basic emotion recognition accuracy or longer response times. However, children with ASD may be relying on other perceptual skills (such as advanced word-word matching) to complete emotion recognition tasks at a similar level as typically developing children.
C1 [Fink, Elian; de Rosnay, Marc; Begeer, Sander] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
   [Wierda, Marlies; Koot, Hans M.; Begeer, Sander] Vrije Univ Amsterdam, Amsterdam, Netherlands.
RP Begeer, S (reprint author), Vrije Univ Amsterdam, Amsterdam, Netherlands.
EM s.begeer@vu.nl
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   BARONCOHEN S, 1993, COGNITION EMOTION, V7, P507, DOI 10.1080/02699939308409202
   Begeer S, 2008, DEV REV, V28, P342, DOI 10.1016/j.dr.2007.09.001
   Boucher J, 2000, J CHILD PSYCHOL PSYC, V41, P847, DOI 10.1017/S0021963099006149
   Dunn L., 2007, MANUAL PEABODY PICTU
   Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
   Gruber C., 2007, SRS MANUAL
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Heerey EA, 2003, EMOTION, V3, P394, DOI 10.1037/1528-3542.3.4.394
   HOBSON RP, 1991, J CHILD PSYCHOL PSYC, V32, P1135, DOI 10.1111/j.1469-7610.1991.tb00354.x
   Hodapp AF, 1999, PSYCHOL REP, V84, P1139, DOI 10.2466/PR0.84.3.1139-1142
   Homer M, 2008, CHILD NEUROPSYCHOL, V14, P419, DOI 10.1080/09297040802291715
   Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   Loveland KA, 2008, NEUROPSYCHOLOGIA, V46, P49, DOI 10.1016/j.neuropsychologia.2007.08.017
   Lundqvist D., 1998, KAROLINSKA DIRECTED
   Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
   Piggot J, 2004, J AM ACAD CHILD PSY, V43, P473, DOI 10.1097/01.chi.0000111363.94169.37
   Roeyers H, 2010, SOCIAL RESPONSIVENES
   Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
   Schlichting L., 2005, PEABODY PICTURE VOCA
   Schultz D, 2001, DEV PSYCHOPATHOL, V13, P53, DOI 10.1017/S0954579401001043
   Smith MJL, 2010, NEUROPSYCHOLOGIA, V48, P2777, DOI 10.1016/j.neuropsychologia.2010.03.008
   Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
   Uljarevic M, 2013, J AUTISM DEV DISORD, V43, P1517, DOI 10.1007/s10803-012-1695-5
   Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
   Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66
NR 29
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2363
EP 2368
DI 10.1007/s10803-014-2084-z
PG 6
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400024
PM 24634064
ER

PT J
AU Albrecht, MA
   Stuart, GW
   Falkmer, M
   Ordqvist, A
   Leung, D
   Foster, JK
   Falkmer, T
AF Albrecht, Matthew A.
   Stuart, Geoffrey W.
   Falkmer, Marita
   Ordqvist, Anna
   Leung, Denise
   Foster, Jonathan K.
   Falkmer, Torbjorn
TI Brief Report: Visual Acuity in Children with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger syndrome; Case control study; ETDRS; High functioning autism;
   Perception; Vision
ID COGNITIVE-STYLE; PERCEPTION; VISION
AB Recently, there has been heightened interest in suggestions of enhanced visual acuity in autism spectrum disorders (ASD) which was sparked by evidence that was later accepted to be methodologically flawed. However, a recent study that claimed children with ASD have enhanced visual acuity (Brosnan et al. in J Autism Dev Disord 42:2491-2497, 2012) repeated a critical methodological flaw by using an inappropriate viewing distance for a computerised acuity test, placing the findings in doubt. We examined visual acuity in 31 children with ASD and 33 controls using the 2 m 2000 Series Revised Early Treatment Diabetic Retinopathy Study chart placed at twice the conventional distance to better evaluate possible enhanced acuity. Children with ASD did not demonstrate superior acuity. The current findings strengthen the argument that reports of enhanced acuity in ASD are due to methodological flaws and challenges the reported association between visual acuity and systemising type behaviours.
C1 [Albrecht, Matthew A.; Foster, Jonathan K.] Curtin Univ, Sch Psychol & Speech Pathol, Curtin Hlth Innovat Res Inst, Perth, WA 6845, Australia.
   [Stuart, Geoffrey W.] La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Melbourne, Vic, Australia.
   [Falkmer, Marita; Leung, Denise; Falkmer, Torbjorn] Curtin Univ, Fac Hlth Sci, Sch Occupat Therapy & Social Work, Curtin Hlth Innovat Res Inst, Perth, WA 6845, Australia.
   [Falkmer, Marita] Jonkoping Univ, Inst Disabil Res, Sch Educ & Commun, CHILD Programme, Jonkoping, Sweden.
   [Ordqvist, Anna; Falkmer, Torbjorn] Linkoping Univ, Fac Hlth Sci, Dept Med & Hlth Sci IMH, Linkoping, Sweden.
   [Ordqvist, Anna; Falkmer, Torbjorn] Cty Council, UHL, Pain & Rehabil Ctr, Linkoping, Sweden.
   [Foster, Jonathan K.] Hlth Dept WA, Neurosci Unit, Perth, WA, Australia.
   [Falkmer, Torbjorn] La Trobe Univ, Sch Occupat Therapy, Melbourne, Vic, Australia.
RP Falkmer, T (reprint author), Curtin Univ, Fac Hlth Sci, Sch Occupat Therapy & Social Work, Curtin Hlth Innovat Res Inst, GPO Box U1987, Perth, WA 6845, Australia.
EM T.Falkmer@curtin.edu.au
CR Applegate R., 2000, J REFRACT SURG, V16, P547
   Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012
   Bach Michael, 2009, Biol Psychiatry, V66, pe19, DOI 10.1016/j.biopsych.2009.02.035
   Bach M, 1996, OPTOMETRY VISION SCI, V73, P49, DOI 10.1097/00006324-199601000-00008
   Bolte S, 2012, J AUTISM DEV DISORD, V42, P726, DOI 10.1007/s10803-011-1300-3
   Brosnan MJ, 2012, J AUTISM DEV DISORD, V42, P2491, DOI 10.1007/s10803-012-1505-0
   Crewther David P, 2009, Biol Psychiatry, V66, pe21, DOI 10.1016/j.biopsych.2009.02.036
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   Falkmer M, 2011, BIOL PSYCHIAT, V70, P812, DOI 10.1016/j.biopsych.2011.07.025
   Falkmer T, 2013, EUR CHILD ADOLES PSY, V22, P329, DOI 10.1007/s00787-013-0375-0
   Haden G., 2008, J AUTISM DEV DISORD, V38, P362, DOI 10.1007/s10803-007-0403-3
   Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Jones MP, 2007, J EXOT PET MED, V16, P69, DOI 10.1053/j.jepm.2007.03.012
   Kaiser Peter K, 2009, Trans Am Ophthalmol Soc, V107, P311
   Keita L, 2010, AUTISM RES, V3, P333, DOI 10.1002/aur.164
   Koh HC, 2010, J AUTISM DEV DISORD, V40, P978, DOI 10.1007/s10803-010-0953-7
   Kruschke JK, 2013, J EXP PSYCHOL GEN, V142, P573, DOI 10.1037/a0029146
   LANGE KL, 1989, J AM STAT ASSOC, V84, P881, DOI 10.2307/2290063
   Milne E, 2009, J AUTISM DEV DISORD, V39, P965, DOI 10.1007/s10803-009-0705-8
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Plummer M., 2011, RJAGS BAYESIAN GRAPH
   PLUMMER M, 2012, R J, V4, P3
   Precision Vision, 2011, REV 2000 SER ETDRS E
   R Development Core Team, 2012, R LANG ENV STAT COMP
   REYMOND L, 1985, VISION RES, V25, P1477, DOI 10.1016/0042-6989(85)90226-3
   SCHARRE JE, 1992, OPTOMETRY VISION SCI, V69, P433, DOI 10.1097/00006324-199206000-00004
   Tavassoli T, 2011, VISION RES, V51, P1778, DOI 10.1016/j.visres.2011.06.004
   Woolfenden S, 2012, RES AUTISM SPECT DIS, V6, P345, DOI 10.1016/j.rasd.2011.06.008
NR 29
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2369
EP 2374
DI 10.1007/s10803-014-2086-x
PG 6
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400025
PM 24639028
ER

PT J
AU Taylor, CM
   Vehorn, A
   Noble, H
   Weitlauf, AS
   Warren, ZE
AF Taylor, Cora M.
   Vehorn, Alison
   Noble, Hylan
   Weitlauf, Amy S.
   Warren, Zachary E.
TI Brief Report: Can Metrics of Reporting Bias Enhance Early Autism
   Screening Measures?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Screening; Early identification; Internal metrics
ID SPECTRUM DISORDERS; MODIFIED CHECKLIST; TODDLERS; CHILDREN; SCALE
AB The goal of the current study was to develop and pilot the utility of two simple internal response bias metrics, over-reporting and under-reporting, in terms of additive clinical value within common screening practices for early detection of autism spectrum disorder risk. Participants were caregivers and children under 36 months of age (n = 145) participating in first-time diagnostic appointments across our clinical research center due to developmental concerns. Caregivers were asked to complete the Modified Checklist for Autism in Toddlers (MCHAT) as well as a questionnaire embedding six response bias indicator questions. These questions were items that in previous clinical studies had been endorsed by an overwhelming majority of parents within clinically identified populations. Results indicated that removal of self-reports indicative of potential response bias dramatically reduced both false positives and false negatives on the MCHAT within this sample. This suggests that future work developing internal metrics of response bias may be promising in addressing limits of current screening measures and practices.
C1 [Taylor, Cora M.; Vehorn, Alison; Noble, Hylan; Weitlauf, Amy S.; Warren, Zachary E.] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Nashville, TN 37235 USA.
   [Weitlauf, Amy S.; Warren, Zachary E.] Vanderbilt Univ, Dept Pediat, Nashville, TN USA.
   [Warren, Zachary E.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37235 USA.
RP Taylor, CM (reprint author), Geisinger Hlth Syst, Autism & Dev Med Inst, 120 Hamm Dr,Suite 2A, Lewisburg, PA 17837 USA.
EM cmtaylor1@geisinger.edu
CR Barton ML, 2012, J AUTISM DEV DISORD, V42, P1165, DOI 10.1007/s10803-011-1343-5
   Butcher J. N., 2001, MINNESOTA MULTIPHASI
   Chlebowski C, 2013, PEDIATRICS, V131, pE1121, DOI 10.1542/peds.2012-1525
   Corsello CM, 2013, J CHILD PSYCHOL PSYC, V54, P178, DOI 10.1111/j.1469-7610.2012.02607.x
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   Miller JS, 2011, PEDIATRICS, V127, P866, DOI 10.1542/peds.2010-0136
   Pandey J, 2008, AUTISM, V12, P513, DOI 10.1177/1362361308094503
   Reynolds C. R., 2006, BEHAV ASSESSMENT SYS
   Robins D., 1999, MODIFIED CHECKLIST A
   Swanson AR, 2014, AUTISM, V18, P555, DOI 10.1177/1362361313481507
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
   Wetherby A. M., 2002, INFANT TODDLER CHECK
   Wetherby AM, 2008, AUTISM, V12, P487, DOI 10.1177/1362361308094501
   Zwiagenbaum L., 2011, AUTISM SPECTRUM DISO, P75
NR 18
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2014
VL 44
IS 9
BP 2375
EP 2380
DI 10.1007/s10803-014-2099-5
PG 6
WC Psychology, Developmental
SC Psychology
GA AN4HW
UT WOS:000340549400026
PM 24682706
ER

PT J
AU Williamson, KE
   Jakobson, LS
AF Williamson, Kathryn E.
   Jakobson, Lorna S.
TI Social perception in children born at very low birthweight and its
   relationship with social/behavioral outcomes
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Prematurity; low birthweight; autism spectrum disorder; social
   perception; social cognition
ID AUTISM SPECTRUM DISORDER; EX-PRETERM INFANTS; BIOLOGICAL MOTION;
   BEHAVIORAL OUTCOMES; ADOLESCENTS BORN; METAANALYSIS; POPULATION;
   PREVALENCE; COGNITION; SKILLS
AB Background: Research has shown that children born very prematurely are at substantially elevated risk for social and behavioral difficulties similar to those seen in full-term children with autism spectrum disorders (ASDs). Methods: To gain insight into core deficits that may underlie these difficulties, in this study, we assessed the social perceptual skills of 8-to 11-year-old children born at very low birthweight (VLBW) (< 1,500 g) and age-matched, full-term controls, using the Child and Adolescent Social Perception Measure. We also assessed social and behavioral outcomes with two parent-report measures used in ASD screening. Results: Children in the preterm group had normal range estimated verbal IQ. However, we found that they were impaired in their ability to use nonverbal cues from moving faces and bodies, and situational cues, to correctly identify the emotions of characters depicted in videotaped social interactions. Their performance on this task was related to the number of 'autistic-like' traits they displayed. Conclusions: This research highlights links between social perceptual deficits and poor social and behavioral outcomes in children born very prematurely. The results also suggest that even those who have escaped major intellectual/language problems are at risk for social and behavioral problems that can be of clinical concern.
C1 [Williamson, Kathryn E.; Jakobson, Lorna S.] Univ Manitoba, Dept Psychol, Winnipeg, MB R3T 2N2, Canada.
RP Jakobson, LS (reprint author), Univ Manitoba, Dept Psychol, Winnipeg, MB R3T 2N2, Canada.
EM jakobson@cc.umanitoba.ca
FU University of Manitoba Graduate Fellowship; Manitoba Institute for Child
   Health/Manitoba Health Research Council Studentship; Natural Sciences
   and Engineering Research Council of Canada
FX This research was supported by a University of Manitoba Graduate
   Fellowship and a Manitoba Institute for Child Health/Manitoba Health
   Research Council Studentship to K. E. W., and by a grant from the
   Natural Sciences and Engineering Research Council of Canada to L. S J.
   The authors have declared that they have no competing or potential
   conflicts of interest. The authors thank Joyce Magill-Evans and Cyndie
   De Koning for advice regarding the scoring of the Child and Adolescent
   Social Perception measure, Sarah Rigby and Lauren Galbraith for their
   help with scoring; the staff of the High-Risk Newborn Follow-up Program,
   and the children and parents who took part in this research.
CR Aarnoudse-Moens CSH, 2009, PEDIATRICS, V124, P717, DOI 10.1542/peds.2008-2816
   Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
   Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   Bhutta AT, 2002, JAMA-J AM MED ASSOC, V288, P728, DOI 10.1001/jama.288.6.728
   Braid S, 2012, ADV NEONAT CARE, V12, P225, DOI 10.1097/ANC.0b013e3182624636
   Capruso D. X., 1995, CLIN NEUROPSYCHOL, P137
   Dahl LB, 2006, PEDIATRICS, V118, pE449, DOI 10.1524/peds.2005-3021
   Dunn L. M., 2007, PEABODY PICTURE VOCA
   Elgen I, 2002, ARCH DIS CHILD, V87, pF128, DOI 10.1136/fn.87.2.F128
   Geldmacher DS, 1996, BRAIN COGNITION, V32, P405, DOI 10.1006/brcg.1996.0073
   Hille ETM, 2008, J PEDIATR, V152, P793, DOI 10.1016/j.jpeds.2007.11.041
   Indredavik MS, 2008, PEDIATRICS, V122, P222, DOI 10.1542/peds.2008-1044
   Johnson S, 2011, PEDIATR RES, V69, p11R, DOI 10.1203/PDR.0b013e318212faa0
   Johnson S, 2007, SEMIN FETAL NEONAT M, V12, P363, DOI 10.1016/j.siny.2007.05.004
   Kniestedt Christoph, 2003, Ophthalmol Clin North Am, V16, P155, DOI 10.1016/S0896-1549(03)00013-0
   Koning C, 2001, AUTISM, V5, P23, DOI 10.1177/1362361301005001003
   Kuban KCK, 2009, J PEDIATR-US, V154, P535, DOI 10.1016/j.jpeds.2008.10.011
   Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
   Limperopoulos C., 2009, CLIN PERINATOL, V36, P792
   MAGILLEVANS J, 1995, J NONVERBAL BEHAV, V19, P151, DOI 10.1007/BF02175502
   Marlow N., 2010, J PEDIAT, V156, P519
   Moore T, 2012, DEV MED CHILD NEUROL, V54, P514, DOI 10.1111/j.1469-8749.2012.04265.x
   Movsas TZ, 2013, J PEDIATR-US, V163, P73, DOI 10.1016/j.jpeds.2012.12.084
   Nadeau L, 2001, J DEV BEHAV PEDIATR, V22, P1
   Norman JF, 2004, PSYCHOL AGING, V19, P219, DOI 10.1037/0882-7974.19.1.219
   Pavlova M, 2008, J COGNITIVE NEUROSCI, V20, P494, DOI 10.1162/jocn.2008.20.3.494
   Pavlova M, 2005, CEREB CORTEX, V15, P594, DOI 10.1093/cercor/bhh162
   Pavlova MA, 2012, CEREB CORTEX, V22, P981, DOI 10.1093/cercor/bhr156
   Pinto-Martin JA, 2011, PEDIATRICS, V128, P883, DOI 10.1542/peds.2010-2846
   Reynolds C. R., 2004, BHEAV ASSESSMENT SYS
   Rickards AL, 2001, J DEV BEHAV PEDIATR, V22, P11
   Semrud-Clikeman M, 2010, J ABNORM CHILD PSYCH, V38, P509, DOI 10.1007/s10802-009-9380-7
   SOMMERFELT K, 1995, ARCH DIS CHILD, V73, pF135, DOI 10.1136/fn.73.3.F135
   Taylor NM, 2009, NEUROPSYCHOLOGIA, V47, P2766, DOI 10.1016/j.neuropsychologia.2009.06.001
   Volker MA, 2010, J AUTISM DEV DISORD, V40, P188, DOI 10.1007/s10803-009-0849-6
   Voss W, 2012, ACTA PAEDIATR, V101, P569, DOI 10.1111/j.1651-2227.2012.02601.x
   Williamson K. E., 2014, THESIS U MANITOBA WI
   Williamson K. E., DEV PSYCHOP IN PRESS
   Wocadlo C, 2006, EUR J DEV PSYCHOL, V3, P48, DOI 10.1080/17405620500361894
   Woodward LJ, 2006, NEW ENGL J MED, V355, P685, DOI 10.1056/NEJMoa053792
NR 41
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2014
VL 55
IS 9
BP 990
EP 998
DI 10.1111/jcpp.12210
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AN2JD
UT WOS:000340410000004
PM 24552579
ER

PT J
AU Kaluzna-Czaplinska, J
   Zurawicz, E
   Struck, W
   Markuszewski, M
AF Kaluzna-Czaplinska, Joanna
   Zurawicz, Ewa
   Struck, Wiktoria
   Markuszewski, Michal
TI Identification of organic acids as potential biomarkers in the urine of
   autistic children using gas chromatography/mass spectrometry
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
   AND LIFE SCIENCES
LA English
DT Article
DE Organic acids; Gas chromatography-mass spectrometry; Biomarkers; Autism;
   Principal component analysis
ID BLOOD-BRAIN-BARRIER; PROPIONIC-ACID; SPECTRUM DISORDERS;
   2-HYDROXYBUTYRIC ACID; CEREBROSPINAL-FLUID; DICARBOXYLIC-ACIDS;
   MASS-SPECTROMETRY; SOCIAL-BEHAVIOR; ASCORBIC-ACID; SAUDI-ARABIA
AB There is a need to identify metabolic phenotypes in autism as they might each require unique approaches to prevention. Biological markers can help define autism subtypes and reveal potential therapeutic targets. The aim of the study was to identify alterations of small molecular weight compounds and to find potential biomarkers. Gas chromatography/mass spectrometry was employed to evaluate major metabolic changes in low molecular weight urine metabolites of 14 children with autism spectrum disorders vs. 10 non-autistic subjects. The results prove the usefulness of an identified set of 21 endogenous compounds (including 14 organic acids), whose levels are changed in diseased children. Gas chromatography/mass spectrometry method combined with multivariate statistical analysis techniques provide an efficient way of depicting metabolic perturbations of diseases, and may potentially be applicable as a novel strategy for the noninvasive diagnosis and treatment of autism. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kaluzna-Czaplinska, Joanna; Zurawicz, Ewa] Lodz Univ Technol, Dept Chem, Inst Gen & Ecol Chem, PL-90924 Lodz, Poland.
   [Struck, Wiktoria; Markuszewski, Michal] Med Univ Gdansk, Dept Biopharm & Pharmacodynam, PL-80416 Gdansk, Poland.
RP Kaluzna-Czaplinska, J (reprint author), Lodz Univ Technol, Dept Chem, Inst Gen & Ecol Chem, Zeromskiego 116, PL-90924 Lodz, Poland.
EM joanna.kaluzna-czaplinska@p.lodz.pl
RI Markuszewski, Michal/E-4768-2011
OI Markuszewski, Michal/0000-0003-1166-4817
CR Al-Yafee YA, 2011, BMC NEUROL, V11, DOI 10.1186/1471-2377-11-139
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Anderson CM, 2013, MOL ASPECTS MED, V34, P516, DOI 10.1016/j.mam.2012.07.010
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Bodansky O, 1942, J AM PHARM ASSOC, V31, P1
   Bongiovanni B., 2003, AMINO ACID PROFILING, V245, P38
   Boris M., 2004, J AM PHYS SURG, V9, P106
   Bralley J., 2001, LAB EVALUATIONS MOL
   Carini C., 2007, DRUGS, V10, P395
   Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6
   Clark-Taylor T, 2004, MED HYPOTHESES, V62, P970, DOI 10.1016/j.mehy.2004.01.011
   Conn A.R., 1983, AM J PHYSIOL, V245, P253
   Deutsch JC, 1998, ANAL BIOCHEM, V255, P1, DOI 10.1006/abio.1997.2293
   DRAWERT F, 1965, NATURWISSENSCHAFTEN, V52, P306
   El-Ansary AK, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-74
   El-Ansary AK, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-62
   Elder JH, 2006, J AUTISM DEV DISORD, V36, P413, DOI 10.1007/s10803-006-0079-0
   Erdman J. W., 2012, PRESENT KNOWLEDGE NU
   Evans C, 2008, NUTR NEUROSCI, V11, P9, DOI 10.1179/147683008X301360
   Fenton T.R., 2009, NUTR J, V8, P1
   Gabathuler R, 2010, NEUROBIOL DIS, V37, P48, DOI 10.1016/j.nbd.2009.07.028
   Gao XF, 2012, BMC SYST BIOL, V6, DOI 10.1186/1752-0509-6-S1-S14
   GILBERG C, 1982, J AUTISM DEV DISORD, V12, P229, DOI 10.1007/BF01531369
   Gold H, 1943, J AM PHARM ASSOC, V32, P173
   Gorina A. S., 2011, Biomeditsinskaya Khimiya, V57, P562
   Gregersen N, 1982, Scand J Clin Lab Invest Suppl, V161, P15
   Hagenbuch B, 2004, PFLUG ARCH EUR J PHY, V447, P653, DOI 10.1007/s00424-003-1168-y
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hasagawa Y., 2005, J CHROMATOGR B, V823, P13
   Hodge H. C., 1984, CLIN TOXICOLOGY COMM, V5th
   HOFFMANN GF, 1993, J INHERIT METAB DIS, V16, P648, DOI 10.1007/BF00711898
   Imaki M., 1995, APPL HUM SCI, V1, P297
   Johnson DW, 2005, CLIN BIOCHEM, V38, P351, DOI 10.1016/j.clinbiochem.2005.01.007
   Kahler SG, 2003, AM J MED GENET C, V117C, P31, DOI 10.1002/ajmg.c.10018
   Kaluzna-Czaplinska J., 2010, MED SCI MONITOR, V16, P488
   Kaluzna-Czaplinska J., 2010, MED SCI MONITOR, V16, P445
   Kaluzna-Czaplinska J, 2011, CLIN BIOCHEM, V44, P686, DOI 10.1016/j.clinbiochem.2011.01.015
   Kaluzna-Czaplinska J., 2013, J CHROMATOGR B
   KANO K, 1992, CLIN CHEM, V38, P624
   Kocovska E, 2012, RES DEV DISABIL, V33, P1541, DOI 10.1016/j.ridd.2012.02.015
   Koepsell H, 2013, MOL ASPECTS MED, V34, P413, DOI 10.1016/j.mam.2012.10.010
   Nyska A, 2002, TOXICOL PATHOL, V30, P620, DOI 10.1080/01926230290166724
   Kolker S, 2008, J INHERIT METAB DIS, V31, P194, DOI 10.1007/s10545-008-0823-z
   KOLVRAA S, 1986, BIOCHIM BIOPHYS ACTA, V876, P515, DOI 10.1016/0005-2760(86)90039-1
   Koulman A, 2009, ANAL BIOANAL CHEM, V394, P663, DOI 10.1007/s00216-009-2690-3
   Kuhara T, 2001, J CHROMATOGR B, V758, P3, DOI 10.1016/S0378-4347(01)00138-4
   LANDAAS S, 1975, CLIN CHIM ACTA, V58, P23, DOI 10.1016/0009-8981(75)90481-7
   Lankinen M, 2011, J NUTR, V141, P31, DOI 10.3945/jn.110.131656
   London E, 2000, ENVIRON HEALTH PERSP, V108, P401
   Lonsdale D., 2011, AUTISM RES TREAT, V2011
   Lord RS, 2008, ALTERN MED REV, V13, P205
   MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
   MacFabe DF, 2011, BEHAV BRAIN RES, V217, P47, DOI 10.1016/j.bbr.2010.10.005
   Mahler H., 1966, BIOL CHEM
   Manning-Courtney Patricia, 2003, Curr Probl Pediatr Adolesc Health Care, V33, P283, DOI 10.1016/S1538-5442(03)00108-1
   Manzi B, 2008, J CHILD NEUROL, V23, P307, DOI 10.1177/0883073807308698
   Markovich D, 2012, CURR TOP MEMBR, V70, P239, DOI 10.1016/B978-0-12-394316-3.00007-7
   Mavel S, 2013, TALANTA, V114, P95, DOI 10.1016/j.talanta.2013.03.064
   McMillan L, 2003, BRIT J CANCER, V88, P748, DOI 10.1038/sj.bjc.6600793
   Meredith D, 2008, XENOBIOTICA, V38, P1072, DOI 10.1080/00498250802010868 
   Ming X, 2012, J PROTEOME RES, V11, P5856, DOI 10.1021/pr300910n
   Moe SM, 2005, AM J KIDNEY DIS, V45, P213, DOI 10.1053/j.ajkd.2004.10.014
   Moretti P, 2005, NEUROLOGY, V64, P1088
   Mortensen P B, 1996, Scand J Gastroenterol Suppl, V216, P132
   MROCHEK JE, 1973, CLIN CHEM, V19, P927
   Murray R.K., 1996, BIOCH HARPERA
   Newschaffer CJ, 2003, PUBLIC HEALTH REP, V118, P393, DOI 10.1016/S0033-3549(04)50270-4
   Nychas GJE, 2002, LETT APPL MICROBIOL, V34, P173, DOI 10.1046/j.1472-765x.2002.01077.x
   Page T., 2000, J AUTISM DEV DISORD, V30, P461
   Pardridge WM, 2007, STROKE, V38, P686, DOI 10.1161/01.STR.0000247887.61831.74
   Pasca SP, 2006, LIFE SCI, V78, P2244, DOI 10.1016/j.lfs.2005.09.040
   Portaluppi F, 2008, CHRONOBIOL INT, V25, P999, DOI 10.1080/07420520802544530
   Ramautar R, 2007, ANAL BIOANAL CHEM, V387, P293, DOI 10.1007/s00216-006-0911-6
   ROBERTSO.B, 1968, ACTA PATHOL MIC SC, V74, P305
   Rogers SA, 2006, ALTERN THER HEALTH M, V12, P44
   Sauer SW, 2010, BBA-MOL BASIS DIS, V1802, P552, DOI 10.1016/j.bbadis.2010.03.003
   Schrocksnadel K, 2006, CLIN CHIM ACTA, V364, P82, DOI 10.1016/j.cca.2005.06.013
   Scott CR, 2006, AM J MED GENET C, V142C, P121, DOI 10.1002/ajmg.c.30092
   Shattock P., 2002, EXPER OPIN THER TAR, V6, P1
   SHAW W, 1995, CLIN CHEM, V41, P1094
   Shaw W., 2006, OXALATES CONTROL IS
   Shaw W, 2000, CLIN PRAC ALTER MED, V1, P15
   Shultz SR, 2008, NEUROPHARMACOLOGY, V54, P901, DOI 10.1016/j.neuropharm.2008.01.013
   Silva AR, 2001, BRAZ J MED BIOL RES, V34, P627
   Styczynski MP, 2007, ANAL CHEM, V79, P966, DOI 10.1021/ac0614846
   Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238
   Tahiroglu A.Y., 2008, TURK J ENDOCRINOL ME, V12, P55
   Theoharides TC, 2008, J CLIN PSYCHOPHARM, V28, P479, DOI 10.1097/JCP.0b013e3181845f48
   THOMAS M, 1983, FOOD CHEM TOXICOL, V21, P449, DOI 10.1016/0278-6915(83)90101-1
   Thomas RH, 2010, J NEUROCHEM, V113, P515, DOI 10.1111/j.1471-4159.2010.06614.x
   Waly M, 2004, MOL PSYCHIATR, V9, P358, DOI 10.1038/sj.mp.4001476
   Webster R., 1930, LEGAL MED TOXICOLOGY
   Wei CM, 2012, MOL BIOSYST, V8, P2197, DOI 10.1039/c2mb25105a
   White JF, 2003, EXP BIOL MED, V228, P639
   Wishart DS, 2009, NUCLEIC ACIDS RES, V37, pD603, DOI 10.1093/nar/gkn810
   Xia JG, 2013, METABOLOMICS, V9, P280, DOI 10.1007/s11306-012-0482-9
   Zafeiriou DI, 2008, BRAIN DEV-JPN, V30, P305, DOI 10.1016/j.braindev.2007.09.005
   Zecavati N, 2009, CURR NEUROL NEUROSCI, V9, P129, DOI 10.1007/s11910-009-0021-x
   Zhang Q, 2007, J CHROMATOGR B, V854, P20, DOI 10.1016/j.jchromb.2007.03.048
   Zurawicz E, 2013, BIOMED CHROMATOGR, V27, P1273, DOI 10.1002/bmc.2911
NR 100
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD SEP 1
PY 2014
VL 966
SI SI
BP 70
EP 76
DI 10.1016/j.jchromb.2014.01.041
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA AN1DP
UT WOS:000340323200008
PM 24565890
ER

PT J
AU Bostrom, PK
   Broberg, M
AF Bostrom, P. K.
   Broberg, M.
TI Openness and avoidance - a longitudinal study of fathers of children
   with intellectual disability
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE autism; Down syndrome; father; intellectual disability; learning
   disability; parents
ID DOWN-SYNDROME; PRESCHOOL-CHILDREN; DEVELOPMENTAL-DISABILITIES; EMOTIONAL
   AVAILABILITY; DISABLED-CHILDREN; PARENTING STRESS; MOTHERS; AUTISM;
   FAMILIES; INVOLVEMENT
AB Background Fathers' interactions with children who have intellectual disabilities (ID) or developmental delays (DD) have increased over the past few decades and may be expected to continue to increase as maternal and paternal roles, along with other gender roles, become more equal. The aim of the present study was to explore fathers' experiences of parenthood in relation to a child with ID/DD from the initial discovery of the disability to 5 years later. Methods Fathers' experiences of parenting children with ID/DD were explored in a longitudinal framework. Seven Swedish fathers of young children with ID/DD participated in a series of semi-structured interviews from 2005 to 2010, and their accounts were subjected to interpretative phenomenological analysis. Results The analysis revealed three themes: (1) An interrupted path - no longer taking things for granted, which describes the fathers' reactions to their children's diagnosis; (2) Being a good father, which describes the fathers' overall perceptions of their parenting of a child with ID/DD; and (3) Dealing with the unexpected, which describes fathers' individual ways of integrating, managing, and living with the knowledge of their child's disability over the 5 years during which fathers were interviewed. Conclusions Fathers' individual paths need to be taken into consideration when offering psychological support to families of children with ID/DD.
C1 [Bostrom, P. K.; Broberg, M.] Univ Gothenburg, Dept Psychol, S-40530 Gothenburg, Sweden.
RP Bostrom, PK (reprint author), Univ Gothenburg, Dept Psychol, Box 500, S-40530 Gothenburg, Sweden.
EM petra.bostrom@psy.gu.se
CR Bell DC, 2000, PSYCHOL INQ, V11, P69, DOI 10.1207/S15327965PLI1102_01
   Benoit D, 1997, J CHILD PSYCHOL PSYC, V38, P307, DOI 10.1111/j.1469-7610.1997.tb01515.x
   Benoit D, 1997, INF MENTAL HLTH J, V18, P107, DOI 10.1002/(SICI)1097-0355(199721)18:1<107::AID-IMHJ8>3.0.CO;2-N
   Biringen Z, 2005, INFANT MENT HEALTH J, V26, P369, DOI 10.1002/imhj.20058
   Bostrom PK, 2011, RES DEV DISABIL, V32, P1860, DOI 10.1016/j.ridd.2011.03.017
   BRESLAU N, 1982, J HEALTH SOC BEHAV, V23, P169, DOI 10.2307/2136513
   BRISTOL MM, 1988, DEV PSYCHOL, V24, P441, DOI 10.1037/0012-1649.24.3.441
   Carpenter B., 2008, SUPPORT LEARNING, V23, P118, DOI DOI 10.1111/J.1467-9604.2008.00382.X
   Chesler MA, 2001, QUAL HEALTH RES, V11, P363, DOI 10.1177/104973201129119163
   Compas BE, 2006, ANN NY ACAD SCI, V1094, P226, DOI 10.1196/annals.1376.024
   Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
   de Falco S, 2009, PARENT-SCI PRACT, V9, P198, DOI 10.1080/15295190902844381
   Dyer WJ, 2009, J EARLY INTERVENTION, V31, P265, DOI 10.1177/0192513X09340386
   Elvin-Nowak Y., 2005, VARLDENS BASTA PAPPA
   Gerstein ED, 2009, J INTELL DISABIL RES, V53, P981, DOI 10.1111/j.1365-2788.2009.01220.x
   Glidden LM, 2006, J INTELL DISABIL RES, V50, P949, DOI 10.1111/j.1365-2788.2006.00929.x
   Gray DE, 2003, SOC SCI MED, V56, P631, DOI 10.1016/S0277-9536(02)00059-X
   Gray DE, 2006, J INTELL DISABIL RES, V50, P970, DOI 10.1111/j.1365-2788.2006.00933.x
   Gray DE, 2002, J INTELLECT DEV DIS, V27, P215, DOI 10.1080/1366825021000008639
   Hauser-Cram P, 2001, MONOGR SOC RES CHILD, V66, P1, DOI 10.1111/1540-5834.00151
   Hornby G., 1996, DISABILITY HANDICAP, V7, P363, DOI 10.1080/02674649266780431
   Houser G., 1991, RES DEV DISABIL, V12, P251
   Kerr DCR, 2009, DEV PSYCHOL, V45, P1257, DOI 10.1037/a0015863
   Lamb Michael E., 2010, ROLE FATHER CHILD DE, V5th
   Larkin Michael, 2006, QUALITATIVE RES PSYC, V3, P102, DOI DOI 10.1191/1478088706QP0620A
   MacDonald E. E., 2010, ROLE FATHER CHILD DE, V5th, P486
   MacDonald EE, 2010, J CHILD FAM STUD, V19, P236, DOI 10.1007/s10826-008-9243-9
   Mayseless O, 2006, CAMB ST SOC, P1, DOI 10.1017/CBO9780511499869
   McCann D., 2005, SEX RELATSH THER, V20, P333, DOI DOI 10.1080/14681990500141840
   Oelofsen N, 2006, J INTELLECT DEV DIS, V31, P1, DOI 10.1080/13668250500349367
   Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
   Olsson MB, 2006, J INTELL DISABIL RES, V50, P963, DOI 10.1111/j.1365-2788.2006.00930.x
   Pelchat D, 2009, J CHILD HEALTH CARE, V13, P239, DOI 10.1177/1367493509336684
   Pleck J. H., 2010, ROLE FATHER CHILD DE, P27
   RODRIGUE JR, 1992, J AUTISM DEV DISORD, V22, P249, DOI 10.1007/BF01058154
   Saloviita T, 2003, J INTELL DISABIL RES, V47, P300, DOI 10.1046/j.1365-2788.2003.00492.x
   Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02
   Schuengel C, 2009, CHILD CARE HLTH DEV, V35, P673, DOI 10.1111/j.1365-2214.2009.00951.x
   Simmerman S, 2001, J INTELLECT DEV DIS, V26, P325
   Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
   Smith J. A., 2009, INTERPRETATIVE PHENO
   Smith J. A., 1998, DOING SOCIAL PSYCHOL, P229
   Socialdepartementet, 2007, JAMST FAM REF
   Sullivan A, 2002, SYNDROME RES PRACTIC, V8, P67
   TRUTE B, 1995, J CHILD PSYCHOL PSYC, V36, P1225, DOI 10.1111/j.1469-7610.1995.tb01367.x
   Tseng YS, 2008, NURS HEALTH SCI, V10, P229, DOI 10.1111/j.1442-2018.2008.00392.x
   Zeanah C. H., 1995, INFANT PSYCHIAT, V4, P539
NR 47
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD SEP
PY 2014
VL 58
IS 9
BP 810
EP 821
DI 10.1111/jir.12093
PG 12
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA AN2OQ
UT WOS:000340425600003
PM 24020633
ER

PT J
AU Kovacs, T
   Bansagi, B
   Kelemen, O
   Keri, S
AF Kovacs, Tamas
   Bansagi, Boglarka
   Kelemen, Oguz
   Keri, Szabolcs
TI Neuregulin 1-Induced AKT and ERK Phosphorylation in Patients with
   Fragile X Syndrome (FXS) and Intellectual Disability Associated with
   Obstetric Complications
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Fragile X syndrome; Neuregulin 1; AKT; ERK
ID MENTAL-RETARDATION PROTEIN; SIGNALING PATHWAY; MESSENGER-RNA;
   SCHIZOPHRENIA; DISORDERS; EXPRESSION; FMRP; AUTISM; DYSFUNCTION;
   MECHANISMS
AB Animal models of fragile X syndrome (FXS) suggest the impairment of the intracellular AKT messenger system, which is activated by neuregulin 1 (NRG1), a key regulator of neurodevelopment. We investigated NRG1-induced activation of the AKT and extracellular signal-regulated kinase (ERK) systems by the measurement of the phosphorylated AKT/ERK to total AKT/ERK ratio in peripheral B lymphoblasts of patients with FXS, IQ-matched controls with intellectual disability (obstetric complications, preterm birth, perinatal hypoxia, and low birth weight), and typically developed healthy participants. Results revealed that patients with FXS displayed decreased AKT but normal ERK activation after the administration of NRG1. IQ-matched controls with intellectual disability displayed intact AKT/ERK activation. In conclusion, FXS, but not intellectual disability associated with obstetric complications, is associated with decreased NRG1-induced AKT phosphorylation.
C1 [Kovacs, Tamas; Keri, Szabolcs] Nyiro Gyula Hosp, Natl Inst Psychiat & Addict, Budapest, Hungary.
   [Bansagi, Boglarka] Semmelweis Univ, Dept Pediat 2, H-1085 Budapest, Hungary.
   [Kelemen, Oguz] Bacs Kiskun Cty Hosp, Ctr Psychiat, Kecskemet, Hungary.
   [Keri, Szabolcs] Univ Szeged, Fac Med, Dept Physiol, H-6720 Szeged, Hungary.
   [Keri, Szabolcs] Budapest Univ Technol & Econ, Dept Cognit Sci, Budapest, Hungary.
RP Keri, S (reprint author), Univ Szeged, Fac Med, Dept Physiol, Dom Sq 10, H-6720 Szeged, Hungary.
EM szkeri2000@yahoo.com
FU  [TAMOP-4.2.2.A-11/1/KONV-2012-0052]
FX This study was supported by TAMOP-4.2.2.A-11/1/KONV-2012-0052.
CR American Association on Intellectual and Developmental Disabilities, 2010, INTELLECTUAL DISABIL
   Backx L, 2009, EUR J HUM GENET, V17, P378, DOI 10.1038/ejhg.2008.180
   Britsch S, 2007, ADV ANAT EMBRYOL CEL, V190, P1
   Brown V, 2001, CELL, V107, P477, DOI 10.1016/S0092-8674(01)00568-2
   Centonze D, 2008, BIOL PSYCHIAT, V63, P963, DOI 10.1016/j.biopsych.2007.09.008
   Cleva RM, 2011, MOLECULES, V16, P2097, DOI 10.3390/molecules16032097
   De Rubeis S, 2011, J NEURODEV DISORD, V3, P257, DOI 10.1007/s11689-011-9087-2
   Fatemi SH, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.46
   Fatemi SH, 2011, NEUROPHARMACOLOGY, V60, P1221, DOI 10.1016/j.neuropharm.2010.11.011
   Fatemi SH, 2010, SCHIZOPHR RES, V124, P246, DOI 10.1016/j.schres.2010.07.017
   Fazzari P, 2010, NATURE, V464, P1376, DOI 10.1038/nature08928
   Fisch GS, 1996, AM J MED GENET, V64, P362, DOI 10.1002/(SICI)1096-8628(19960809)64:2<362::AID-AJMG25>3.0.CO;2-C
   Ghosh A, 2013, NAT REV DRUG DISCOV, V12, P777, DOI 10.1038/nrd4102
   Hagerman RJ, 2011, BIOL PSYCHIAT, V70, P802, DOI 10.1016/j.biopsych.2011.09.009
   Harrison PJ, 2006, BIOL PSYCHIAT, V60, P132, DOI 10.1016/j.biopsych.2005.11.002
   Hessl D, 2011, BIOL PSYCHIAT, V70, P859, DOI 10.1016/j.biopsych.2011.05.033
   Hoeffer CA, 2012, GENES BRAIN BEHAV, V11, P332, DOI 10.1111/j.1601-183X.2012.00768.x
   Hong A, 2012, J MOL NEUROSCI, V46, P272, DOI 10.1007/s12031-011-9531-5
   Hou LF, 2004, J NEUROSCI, V24, P6352, DOI 10.1523/JNEUROSCI.0995-04.2004
   Hu HL, 2008, J NEUROSCI, V28, P7847, DOI 10.1523/JNEUROSCI.1496-08.2008
   Jaaro-Peled H, 2009, TRENDS NEUROSCI, V32, P485, DOI 10.1016/j.tins.2009.05.007
   Jeon SJ, 2012, J NEUROCHEM, V123, P226, DOI 10.1111/j.1471-4159.2012.07886.x
   Jeon SJ, 2011, J BIOMED SCI, V13, P17, DOI DOI 10.1186/1423-0127-18-17
   Kanakry CG, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001369
   Kelemen O, 2013, PROG NEURO-PSYCHOPH, V46, P92, DOI 10.1016/j.pnpbp.2013.06.017
   Keri S, 2011, SCHIZOPHRENIA BULL, V37, P141, DOI 10.1093/schbul/sbp063
   Keri S, 2009, NEUROCHEM INT, V55, P606, DOI 10.1016/j.neuint.2009.06.002
   Keri S, 2010, AM J PSYCHIAT, V167, P444, DOI 10.1176/appi.ajp.2009.09050723
   Kovacs T, 2013, PSYCHIAT RES, V210, P690, DOI 10.1016/j.psychres.2012.12.022
   Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
   Kurnianingsih YA, 2011, J NEURAL TRANSM, V118, P1621, DOI 10.1007/s00702-011-0672-z
   Li RN, 2013, LIFE SCI, V92, P747, DOI 10.1016/j.lfs.2013.02.014
   Loat CS, 2006, ANN HUM GENET, V70, P555, DOI 10.1111/j.1469-1809.2006.00269.x
   Lugo JN, 2013, LEARN MEMORY, V20, P670, DOI 10.1101/lm.032839.113
   Macpherson J, 2005, PRACTICE GUIDELINES
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   O'Donnell WT, 2002, ANNU REV NEUROSCI, V25, P315, DOI 10.1146/annurev.neuro.25.112701.142909
   Paluszkiewicz SM, 2011, DEV NEUROSCI-BASEL, V33, P349, DOI 10.1159/000329420
   Reiss AL, 2007, CHILD ADOL PSYCH CL, V16, P663, DOI 10.1016/j.chc.2007.03.001
   Rousseau François, 2011, Clin Biochem Rev, V32, P135
   Rustan OG, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-41
   Sei Y, 2007, MOL PSYCHIATR, V12, P946, DOI 10.1038/sj.mp.4001994
   Sei Y, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010789
   Seres I, 2010, NEUROCHEM INT, V56, P906, DOI 10.1016/j.neuint.2010.03.018
   Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
   Sokol DK, 2011, NEUROLOGY, V76, P1344, DOI 10.1212/WNL.0b013e3182166dc7
   Ting AK, 2011, J NEUROSCI, V31, P15, DOI 10.1523/JNEUROSCI.2538-10.2011
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Willemsen R, 2011, CLIN GENET, V80, P214, DOI 10.1111/j.1399-0004.2011.01723.x
   Zeng L, 2013, ELECTROPHORESIS, V34, P2234, DOI 10.1002/elps.201300140
NR 50
TC 0
Z9 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD SEP
PY 2014
VL 54
IS 1
BP 119
EP 124
DI 10.1007/s12031-014-0257-z
PG 6
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AN3GP
UT WOS:000340474200013
PM 24563264
ER

PT J
AU Cortez, MD
   de Rose, JC
   Miguel, CF
AF Cortez, Mariele Diniz
   de Rose, Julio C.
   Miguel, Caio F.
TI The Role of Correspondence Training on Children's Self-Report Accuracy
   across Tasks
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE Correspondence training; Do-say correspondence; Generalization; Lying;
   Self-report
ID VERBAL NONVERBAL CORRESPONDENCE; ACTIVITY SCHEDULES; INCREASING PLAY;
   VERBALIZATION; BEHAVIOR; REINFORCEMENT; MAINTENANCE; THOUGHTS; AUTISM;
   SAMPLE
AB This study investigated children's self-report accuracy as a function of task type and also verified generalization of do-say correspondence across tasks. Six children between 6 and 11 years of age participated in the study. "Doing" consisted of reading words, playing a computer game, solving a math problem, and labeling music-related stimuli. "Saying" consisted of reporting on the accuracy of performance following the automated computer feedback. Baseline assessed correspondence for the different tasks. Correspondence training was conducted for the task in which levels of accuracy were the lowest. Generalized do-say correspondence was then assessed in untrained tasks. For four children, correspondence was lowest for the academic tasks. Four of six children exhibited generalized correspondence after the first training, and the remaining two children did so following a second training with a different task. Distinct tasks seemed to control different patterns of self-report accuracy. Results on generalization indicated do-say correspondence as a generalized operant behavior.
C1 [Cortez, Mariele Diniz; de Rose, Julio C.] Univ Fed Sao Carlos, BR-13560 Sao Carlos, SP, Brazil.
   [Cortez, Mariele Diniz; de Rose, Julio C.] Inst Nacl Ciencia & Tecnol Comportamento Cognicao, Sao Carlos, SP, Brazil.
   [Miguel, Caio F.] Calif State Univ Sacramento, Sacramento, CA 95819 USA.
   [de Rose, Julio C.] Dept Psicol, BR-13565905 Sao Paulo, Brazil.
RP de Rose, JC (reprint author), Dept Psicol, Rodovia Washington Luis,Km 235 SP 310, BR-13565905 Sao Paulo, Brazil.
EM juliocderose@yahoo.com.br
CR Baer R. A., 1983, ED TREATMENT CHILDRE, V6, P379
   BAER RA, 1990, J EXP ANAL BEHAV, V54, P23, DOI 10.1901/jeab.1990.54-23
   BAER RA, 1987, J APPL BEHAV ANAL, V20, P179, DOI 10.1901/jaba.1987.20-179
   BAER RA, 1984, J APPL BEHAV ANAL, V17, P429, DOI 10.1901/jaba.1984.17-429
   BAER RA, 1988, J APPL BEHAV ANAL, V21, P345, DOI 10.1901/jaba.1988.21-345
   BAER RA, 1985, BEHAV MODIF, V9, P477, DOI 10.1177/01454455850094005
   Ballard K. D., 1981, EXCEPT CHILDREN, V28, P55, DOI [10.1080/0156655810280106, DOI 10.1080/0156655810280106]
   Beckert M. E., 2005, ANALISE COMPORTAMENT, P229
   Bevill AR, 2001, J EARLY INTERVENTION, V24, P129
   Brino A. L. F., 2006, REV BRASILEIRA ANAL, V2, P67
   Cortez M. D., 2013, ACTA COMPORTAMENTALI, V21, P139
   CRITCHFIELD TS, 1990, J EXP ANAL BEHAV, V53, P321, DOI 10.1901/jeab.1990.53-321
   CRITCHFIELD TS, 1993, J EXP ANAL BEHAV, V59, P193, DOI 10.1901/jeab.1993.59-193
   Domeniconi C, 2014, PSYCHOL REC, V64, P381, DOI 10.1007/s40732-014-0009-z
   DEACON JR, 1987, J APPL BEHAV ANAL, V20, P391, DOI 10.1901/jaba.1987.20-391
   Glenn S S, 1983, Behav Anal, V6, P47
   Greer RD, 2009, PSYCHOL REC, V59, P449
   GUEVREMONT DC, 1986, J APPL BEHAV ANAL, V19, P215, DOI 10.1901/jaba.1986.19-215
   GUEVREMONT DC, 1986, J APPL BEHAV ANAL, V19, P99, DOI 10.1901/jaba.1986.19-99
   ISRAEL AC, 1978, J APPL BEHAV ANAL, V11, P271, DOI 10.1901/jaba.1978.11-271
   KARLAN GR, 1982, J APPL BEHAV ANAL, V15, P151, DOI 10.1901/jaba.1982.15-151
   Lima EL, 2010, J APPL BEHAV ANAL, V43, P411, DOI 10.1901/jaba.2010.43-411
   Lloyd KE, 2002, BEHAV ANALYST, V25, P57
   Luciano MC, 2001, PSYCHOL REC, V51, P111
   Luciano-Soriano MC, 2000, RES DEV DISABIL, V21, P355, DOI 10.1016/S0891-4222(00)00048-2
   Machalicek W, 2009, RES AUTISM SPECT DIS, V3, P547, DOI 10.1016/j.rasd.2008.11.003
   Michael J, 2004, CONCEPTS PRINCIPLES
   Morrison RS, 2002, J EARLY INTERVENTION, V25, P58, DOI 10.1177/105381510202500106
   PANIAGUA FA, 1989, PSYCHOL REP, V64, P971
   RIBEIRO AD, 1989, J EXP ANAL BEHAV, V51, P361
   RISLEY TR, 1968, J APPL BEHAV ANAL, V1, P267, DOI 10.1901/jaba.1968.1-267
   Roca J. V., 1996, ED TREATMENT CHILDRE, V19, P408
   Rosa Filho A. B., 1998, APRENDENDO LER ESCRE
   Skinner B. F., 1957, VERBAL BEHAV
   Stein LM, 1994, TDE TESTE DESEMPENHO
   Stokes JV, 2004, BEHAV INTERVENT, V19, P121, DOI 10.1002/bin.153
   WARD WD, 1990, J APPL BEHAV ANAL, V23, P129, DOI 10.1901/jaba.1990.23-129
   WATSON PJ, 1981, J BEHAV THER EXP PSY, V12, P257, DOI 10.1016/0005-7916(81)90055-0
   Williams J. A., 1982, CHILD FAM BEHAV THER, V4, P11
   WILSON PG, 1992, J APPL BEHAV ANAL, V25, P681, DOI 10.1901/jaba.1992.25-681
NR 40
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD SEP
PY 2014
VL 64
IS 3
BP 393
EP 402
DI 10.1007/s40732-014-0061-8
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA AN1VS
UT WOS:000340372700005
ER

PT J
AU Perez-Gonzalez, LA
   Belloso-Diaz, C
   Carames-Mendez, M
   Alonso-Alvarez, B
AF Antonio Perez-Gonzalez, Luis
   Belloso-Diaz, Carlota
   Carames-Mendez, Maria
   Alonso-Alvarez, Benigno
TI Emergence of Complex Intraverbals Determined by Simpler Intraverbals
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE Intraverbals; Verbal behavior; Stimulus equivalence; Stimulus relations;
   Reasoning; Answering questions; Adults
ID STIMULUS-CONTROL PROCEDURES; DEVELOPMENTAL-DISABILITIES; EMERGING
   SPEECH; CHILDREN; BEHAVIOR; RESPONSES; AUTISM
AB This research explored some factors involved in the emergence of intraverbals as demonstrated by P,rez-Gonzalez, Herszlikowicz, and Williams (2008) in three experiments. Eleven adults learned to say the chemical elements corresponding to two chemical groups (the A-B relations) and to say the atomic numbers of two elements (the B-C relations). Thereafter, we probed the relations that result from combining these stimuli. For example, we asked the groups corresponding to the atomic numbers (the C-A relations). In Experiment 1, we taught A-B and B-C and probed the remaining relations without additional teaching. In Experiment 2, with Categories, participants learned to say the categories of the exemplars (i.e., "What is polonium?" -the correct answer was "an element"). In Experiment 3, with Exemplars, participants learned to say the exemplars of the categories (i.e., "Name a chemical element"; the correct answers were the two chemical elements). The Categories facilitated emergence in some but not all participants. The Exemplars was shown to be effective in promoting the emergence of the emergent relations. These results indicate that the simpler intraverbals (Categories and Exemplars) play a role in the emergence of the more complex intraverbals.
C1 [Antonio Perez-Gonzalez, Luis; Belloso-Diaz, Carlota; Carames-Mendez, Maria; Alonso-Alvarez, Benigno] Univ Oviedo, Dept Psychol, Oviedo 33003, Spain.
RP Perez-Gonzalez, LA (reprint author), Univ Oviedo, Dept Psychol, Plaza Feijoo S-N Despacho 209, Oviedo 33003, Spain.
EM laperez@uniovi.es
RI Perez-Gonzalez, Luis/L-2338-2014
CR Axe Judah B, 2008, Anal Verbal Behav, V24, P159
   BRAAM SJ, 1983, APPL RES MENT RETARD, V4, P279, DOI 10.1016/0270-3092(83)90030-9
   Carp CL, 2012, PSYCHOL REC, V62, P187
   CHASE PN, 1985, J EXP ANAL BEHAV, V43, P301, DOI 10.1901/jeab.1985.43-301
   Cihon Traci M, 2007, Anal Verbal Behav, V23, P123
   Finkel A. S., 2001, ANAL VERBAL BEHAV, V18, P61
   Goldsmith TR, 2007, RES AUTISM SPECT DIS, V1, P1, DOI 10.1016/j.rasd.2006.07.001
   Greer R Douglas, 2005, Anal Verbal Behav, V21, P99
   Ingvarsson E. T., 2010, J APPL BEHAV ANAL, V43, P11
   Ingvarsson ET, 2007, J APPL BEHAV ANAL, V40, P411, DOI 10.1901/jaba.2007.40-411
   Ingvarsson ET, 2012, RES AUTISM SPECT DIS, V6, P654, DOI 10.1016/j.rasd.2011.09.009
   Kahneman D., 2011, THINKING FAST SLOW
   Kelley ME, 2007, J APPL BEHAV ANAL, V40, P431, DOI 10.1901/jaba.2007.40-431
   Kisamore AN, 2011, J APPL BEHAV ANAL, V44, P255, DOI 10.1901/jaba.2011.44-255
   LAMARRE J, 1985, J EXP ANAL BEHAV, V43, P5, DOI 10.1901/jeab.1985.43-5
   Lerman DC, 2005, J APPL BEHAV ANAL, V38, P303, DOI 10.1901/jaba.2005.106-04
   LUCIANO MC, 1986, APPL RES MENT RETARD, V7, P1
   Miguel Caio F, 2005, Anal Verbal Behav, V21, P27
   Partington J W, 1993, Anal Verbal Behav, V11, P9
   Perez-Gonzalez L. A., 2013, UNIDIRECTIONAL UNPUB
   Perez-Gonzalez L. A., 2005, 2 C EUR ASS BEH AN
   Perez-Gonzalez L. A., 2014, INT J BEHAV IN PRESS
   Perez-Gonzalez L. A., 2006, ANN C ASS BEH AN
   Perez-Gonzalez LA, 2008, PSYCHOL REC, V58, P95
   Perez-Gonzalez LA, 2007, J APPL BEHAV ANAL, V40, P697, DOI 10.1901/jaba.2007.697-701
   Petursdottir AI, 2008, J APPL BEHAV ANAL, V41, P411, DOI 10.1901/jaba.2008.41-411
   Petursdottir AI, 2008, J APPL BEHAV ANAL, V41, P53, DOI 10.1901/jaba.2008.41-53
   Petursdottir AI, 2009, J APPL BEHAV ANAL, V42, P685, DOI 10.1901/jaba.2009.42-685
   Polson D A, 2000, Anal Verbal Behav, V17, P105
   Saunders RR, 1999, J EXP ANAL BEHAV, V72, P117, DOI 10.1901/jeab.1999.72-117
   Sautter RA, 2011, J APPL BEHAV ANAL, V44, P227, DOI 10.1901/jaba.2011.44-227
   Skinner B. F., 1957, VERBAL BEHAV
   Sundberg C T, 1990, Anal Verbal Behav, V8, P31
   Sundberg M L, 1990, Anal Verbal Behav, V8, P83
   Vedora Joseph, 2009, Anal Verbal Behav, V25, P79
   Vignes Tore, 2007, Anal Verbal Behav, V23, P113
   Watkins C L, 1989, Anal Verbal Behav, V7, P69
NR 37
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD SEP
PY 2014
VL 64
IS 3
BP 509
EP 526
DI 10.1007/s40732-014-0047-6
PG 18
WC Psychology, Multidisciplinary
SC Psychology
GA AN1VS
UT WOS:000340372700017
ER

PT J
AU Gliga, T
   Jones, EJH
   Bedford, R
   Charman, T
   Johnson, MH
AF Gliga, T.
   Jones, E. J. H.
   Bedford, R.
   Charman, T.
   Johnson, M. H.
TI From early markers to neuro-developmental mechanisms of autism
SO DEVELOPMENTAL REVIEW
LA English
DT Article
DE Infants; Autism; The "social brain"; Sensory processing
ID SPECTRUM DISORDERS; EXECUTIVE FUNCTION; SOCIAL-PERCEPTION; JOINT
   ATTENTION; YOUNG-CHILDREN; EYE-GAZE; COMMUNICATION DIFFICULTIES;
   FUNCTIONAL CONNECTIVITY; ORBITOFRONTAL CORTEX; BIOLOGICAL MOTION
AB A fast growing field, the study of infants at risk because of having an older sibling with autism (i.e. infant sibs) aims to identify the earliest signs of this disorder, which would allow for earlier diagnosis and intervention. More importantly, we argue, these studies offer the opportunity to validate existing neuro-developmental models of autism against experimental evidence. Although autism is mainly seen as a disorder of social interaction and communication, emerging early markers do not exclusively reflect impairments of the "social brain". Evidence for atypical development of sensory and attentional systems highlight the need to move away from localized deficits to models suggesting brain-wide involvement in autism pathology. We discuss the implications infant sibs findings have for future work into the biology of autism and the development of interventions. (c) 2014 The Authors. Published by Elsevier Inc.
C1 [Gliga, T.; Jones, E. J. H.; Johnson, M. H.] Univ London Birkbeck Coll, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
   [Bedford, R.] Kings Coll London, Inst Psychiat, Dept Biostat, London WC2R 2LS, England.
   [Charman, T.] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England.
RP Gliga, T (reprint author), Univ London Birkbeck Coll, Ctr Brain & Cognit Dev, Malet St, London WC1E 7HX, England.
EM t.gliga@bbk.ac.uk
CR Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514
   Alvarez JA, 2006, NEUROPSYCHOL REV, V16, P17, DOI 10.1007/s11065-006-9002-x
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Annaz D., 2009, DEVELOPMENTAL SCI, V13, P826
   Azzi JCB, 2012, P NATL ACAD SCI USA, V109, P2126, DOI 10.1073/pnas.1111715109
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Bedford R, 2014, DEVELOPMENTAL SCI, V17, P612, DOI 10.1111/desc.12139
   Bedford R., 2012, THESIS
   Bedford R, 2012, J AUTISM DEV DISORD, V42, P2208, DOI 10.1007/s10803-012-1450-y
   Ben-Sasson A, 2013, J CHILD PSYCHOL PSYC, V54, P846, DOI 10.1111/jcpp.12035
   Ben-Sasson A, 2013, RES AUTISM SPECT DIS, V7, P879, DOI 10.1016/j.rasd.2013.03.006
   Berridge KC, 2009, CURR OPIN PHARMACOL, V9, P65, DOI 10.1016/j.coph.2008.12.014
   Blasi A, 2011, CURR BIOL, V21, P1220, DOI 10.1016/j.cub.2011.06.009
   Blasi A., 2013, P ROYAL SOC, V280
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   BRADLEY L, 1983, NATURE, V301, P419, DOI 10.1038/301419a0
   Buitelaar J. K., 2012, J AM ACAD CHILD ADOL
   Chawarska K, 2013, BIOL PSYCHIAT, V74, P195, DOI 10.1016/j.biopsych.2012.11.022
   Chawarska K, 2012, J CHILD PSYCHOL PSYC, V53, P903, DOI 10.1111/j.1469-7610.2012.02538.x
   Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Clifford SM, 2013, J AUTISM DEV DISORD, V43, P673, DOI 10.1007/s10803-012-1612-y
   Corrigan NM, 2013, JAMA PSYCHIAT, V70, P964, DOI 10.1001/jamapsychiatry.2013.1388
   Cortese S, 2012, AM J PSYCHIAT, V169, P1038, DOI 10.1176/appi.ajp.2012.11101521
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   de Zeeuw P, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051416
   de Klerk CCJM, 2014, DEVELOPMENTAL SCI, V17, P596, DOI 10.1111/desc.12141
   Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
   Diamond A, 2007, SCIENCE, V318, P1387, DOI 10.1126/science.1151148
   Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026
   Elison JT, 2013, AM J PSYCHIAT, V170, P899, DOI 10.1176/appi.ajp.2012.12091150
   Elison JT, 2013, DEVELOPMENTAL SCI, V16, P186, DOI 10.1111/desc.12015
   Elsabbagh M, 2013, BIOL PSYCHIAT, V74, P189, DOI 10.1016/j.biopsych.2012.11.030
   Elsabbagh M, 2012, CURR BIOL, V22, P338, DOI 10.1016/j.cub.2011.12.056
   Elsabbagh M., 2012, BEHAV BRAIN RES, V251, P147
   Escalona A, 2001, J AUTISM DEV DISORD, V31, P513, DOI 10.1023/A:1012273110194
   Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
   Farroni T, 2003, J EXP CHILD PSYCHOL, V85, P199, DOI 10.1016/S0022-0965(03)00022-5
   Field T, 2001, AUTISM, V5, P317, DOI 10.1177/1362361301005003008
   Field T, 1997, J AUTISM DEV DISORD, V27, P333, DOI 10.1023/A:1025858600220
   Fischer J., 2013, CLIN PSYCHOL SCI
   Flanagan JE, 2012, AM J OCCUP THER, V66, P577, DOI 10.5014/ajot.2012.004192
   Fox MD, 2012, NEUROIMAGE, V62, P2232, DOI 10.1016/j.neuroimage.2012.03.035
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
   Gliga T, 2007, PROG BRAIN RES, V164, P323, DOI 10.1016/S0079-6123(07)64018-7
   Grossmann T, 2007, SOC COGN AFFECT NEUR, V2, P284, DOI 10.1093/scan/nsm025
   Guiraud JA, 2011, NEUROREPORT, V22, P845, DOI 10.1097/WNR.0b013e32834c0bec
   Gurevitz M., 2012, J ATTEN DISORD, V18, P14
   Habas PA, 2012, CEREB CORTEX, V22, P13, DOI 10.1093/cercor/bhr053
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Hepper PG, 2012, DEVELOPMENTAL SCI, V15, P373, DOI 10.1111/j.1467-7687.2011.01132.x
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hu V. W., 2012, CHILD DEV, V84, P89
   Jackson BL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066797
   Jam M., 2011, MOL PSYCHIATR, V17, P741
   Johnson M. H., NEUROSCIENC IN PRESS
   Johnson MH, 2012, TRENDS COGN SCI, V16, P454, DOI 10.1016/j.tics.2012.07.001
   Johnson MH, DEV PSYCHOP IN PRESS
   Johnson MH, 2005, NAT REV NEUROSCI, V6, P766, DOI 10.1038/nrn1766
   Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
   Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Kadosh RC, 2010, CURR BIOL, V20, P2016, DOI 10.1016/j.cub.2010.10.007
   Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
   Kaiser MD, 2012, SOC NEUROSCI-UK, V7, P301, DOI 10.1080/17470919.2011.614003
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Kawakubo Y, 2007, CLIN NEUROPHYSIOL, V118, P1464, DOI 10.1016/j.clinph.2007.04.015
   Kennedy DP, 2010, NEUROPSYCHOLOGIA, V48, P3392, DOI 10.1016/j.neuropsychologia.2010.06.025
   Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
   Kikuchi Y, 2009, CHILD DEV, V80, P1421, DOI 10.1111/j.1467-8624.2009.01342.x
   Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
   Klin A, 2008, DEVELOPMENTAL SCI, V11, P40, DOI 10.1111/j.1467-7687.2007.00608.x
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Klingberg T, 2010, TRENDS COGN SCI, V14, P317, DOI 10.1016/j.tics.2010.05.002
   Lakatos K, 2003, MOL PSYCHIATR, V8, P90, DOI 10.1038/sj.mp.4001212
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Landa RJ, 2013, CHILD DEV, V84, P429, DOI 10.1111/j.1467-8624.2012.01870.x
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
   Lang R, 2012, RES AUTISM SPECT DIS, V6, P1004, DOI 10.1016/j.rasd.2012.01.006
   Leekam SR, 2011, PSYCHOL BULL, V137, P562, DOI 10.1037/a0023341
   Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261
   Leonard H., 2013, EUROPEAN J DEV PSYCH, V11, P18
   Little VM, 1999, DEV NEUROPSYCHOL, V16, P455, DOI 10.1207/S15326942DN1603_26
   Lloyd-Fox S, 2009, CHILD DEV, V80, P986, DOI 10.1111/j.1467-8624.2009.01312.x
   Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
   MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x
   Messinger D, 2013, J AM ACAD CHILD PSY, V52, P300, DOI 10.1016/j.jaac.2012.12.011
   Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Narayana S, 2014, NEUROIMAGE, V85, P971, DOI 10.1016/j.neuroimage.2013.07.024
   Nguyen MN, 2013, EUR J NEUROSCI, V37, P35, DOI 10.1111/ejn.12020
   Nickel LR, 2013, INFANCY, V18, P639, DOI 10.1111/infa.12025
   Nordahl CW, 2012, ARCH GEN PSYCHIAT, V69, P53, DOI 10.1001/archgenpsychiatry.2011.145
   Osborne LC, 2005, NATURE, V437, P412, DOI 10.1038/nature03961
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Ozonoff S., 2011, PEDIATRICS, V128, P488, DOI DOI 10.1542/PEDS.2010-2825
   Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
   Parr JR, 2010, DEV MED CHILD NEUROL, V52, P917, DOI 10.1111/j.1469-8749.2010.03664.x
   Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
   Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
   Peterson CC, 1999, PSYCHOL SCI, V10, P126, DOI 10.1111/1467-9280.00119
   Plomin R, 2009, NAT REV GENET, V10, P872, DOI 10.1038/nrg2670
   Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
   Rai D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2059
   Rhodes G., 2013, PLOS ONE
   Rilling JK, 2008, CURR OPIN NEUROBIOL, V18, P159, DOI 10.1016/j.conb.2008.06.003
   Robinson EB, 2013, P NATL ACAD SCI USA, V110, P5258, DOI 10.1073/pnas.1211070110
   Rolls ET, 2000, CEREB CORTEX, V10, P284, DOI 10.1093/cercor/10.3.284
   Ronald A., 2011, FRONT PSYCHOL, V1, P223
   Ronemus M, 2014, NAT REV GENET, V15, P133, DOI 10.1038/nrg3585
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Rozga A, 2011, J AUTISM DEV DISORD, V41, P287, DOI 10.1007/s10803-010-1051-6
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Rueda MR, 2005, DEV NEUROPSYCHOL, V28, P573, DOI 10.1207/s15326942dn2802_2
   Russo N, 2009, J AUTISM DEV DISORD, V39, P1185, DOI 10.1007/s10803-009-0737-0
   Sali AW, 2012, VIS COGN, V20, P1039, DOI 10.1080/13506285.2012.726479
   Senju A., 2013, SOCIAL COGNITIVE AFF
   Sharp H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045446
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Steiner AM, 2012, J AUTISM DEV DISORD, V42, P1183, DOI 10.1007/s10803-011-1376-9
   Swartz JR, 2013, J AM ACAD CHILD PSY, V52, P84, DOI 10.1016/j.jaac.2012.10.012
   Symons LA, 1998, INFANT BEHAV DEV, V21, P531, DOI 10.1016/S0163-6383(98)90026-1
   Tamm L., 2008, MED PSYCHIAT, V37, P397
   Tanaka JW, 2012, J CHILD PSYCHOL PSYC, V53, P1259, DOI 10.1111/j.1469-7610.2012.02571.x
   Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
   Thomas DG, 1997, DEV NEUROPSYCHOL, V13, P205
   TODA S, 1993, DEV PSYCHOL, V29, P532, DOI 10.1037//0012-1649.29.3.532
   Tsai LY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0084978
   Ulrich DA, 2001, PEDIATRICS, V108, part. no., DOI 10.1542/peds.108.5.e84
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wallace KS, 2010, J CHILD PSYCHOL PSYC, V51, P1300, DOI 10.1111/j.1469-7610.2010.02308.x
   Wan MW, 2013, J CHILD PSYCHOL PSYC, V54, P763, DOI 10.1111/jcpp.12032
   Wass S, 2011, CURR BIOL, V21, P1543, DOI 10.1016/j.cub.2011.08.004
   Weinberg MK, 1996, CHILD DEV, V67, P905, DOI 10.1111/j.1467-8624.1996.tb01772.x
   Imada Allicia, 2012, Front Integr Neurosci, V6, P127, DOI 10.3389/fnint.2012.00127
   Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
   Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
   Woolfenden S, 2012, RES AUTISM SPECT DIS, V6, P345, DOI 10.1016/j.rasd.2011.06.008
   Yacubian J, 2007, P NATL ACAD SCI USA, V104, P8125, DOI 10.1073/pnas.0702029104
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
   Zatorre RJ, 2012, NAT NEUROSCI, V15, P528, DOI 10.1038/nn.3045
   Zeeland S.-V., 2010, AUTISM RES, V3, P53, DOI DOI 10.1002/AUR.122
   Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
   Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 154
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2297
EI 1090-2406
J9 DEV REV
JI Dev. Rev.
PD SEP
PY 2014
VL 34
IS 3
BP 189
EP 207
DI 10.1016/j.dr.2014.05.003
PG 19
WC Psychology, Developmental
SC Psychology
GA AM6OU
UT WOS:000339985300001
ER

PT J
AU Lo, YY
   Burk, B
   Anderson, AL
AF Lo, Ya-yu
   Burk, Bradley
   Anderson, Adrienne L.
TI Using Progressive Video Prompting to Teach Students with Moderate
   Intellectual Disability to Shoot a Basketball
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID DAILY LIVING SKILLS; AUTISM SPECTRUM DISORDERS; OF-THE-LITERATURE;
   DEVELOPMENTAL-DISABILITIES; COOKING SKILLS; INTERVENTION; INDIVIDUALS;
   ADOLESCENTS; INSTRUCTION; CHILDREN
AB The current study examined the effects of a modified video prompting procedure, namely progressive video prompting, to increase technique accuracy of shooting a basketball in the school gymnasium of three 11th-grade students with moderate intellectual disability. The intervention involved participants viewing video clips of an adult model who showed progressively chucked steps for making a free throw. We used a single-case, multiple probe across participants design to evaluate the intervention effects. The results of this study showed that all three participants increased the number of steps performed correctly and maintained the skill at the 1-week and 2-week maintenance check without the video viewing. Implications for practice and future research related to video prompting variations are discussed.
C1 [Lo, Ya-yu] Univ N Carolina, Charlotte, NC 28223 USA.
   [Anderson, Adrienne L.] Western Carolina Univ, Cullowhee, NC USA.
RP Lo, YY (reprint author), Univ N Carolina, Dept Special Educ & Child Dev, 9201 Univ City Blvd, Charlotte, NC 28223 USA.
EM ylo1@uncc.edu
CR Apple Inc, 2010, IMOVIE VERS 8 0 6
   Ayres KM, 2005, EDUC TRAIN DEV DISAB, V40, P183
   Banda DR, 2011, EDUC TRAIN AUTISM DE, V46, P514
   Bellini S, 2007, EXCEPT CHILDREN, V73, P264
   Boyer E, 2009, J APPL BEHAV ANAL, V42, P855, DOI 10.1901/jaba.2009.42-855
   Cannella-Malone H, 2006, EDUC TRAIN DEV DISAB, V41, P344
   Cannella-Malone HI, 2011, J POSIT BEHAV INTERV, V13, P144, DOI 10.1177/1098300710366593
   Centers for Disease Control and Prevention, 2010, OB TRENDS US AD 1985
   Centers for Disease Control and Prevention, 2010, STAT IND REP PHYS AC
   Cihak D., 2006, FOCUS AUTISM OTHER D, V21, P89, DOI DOI 10.1177/10883576060210020601
   Columna L., 2009, Journal of Physical Education, Recreation & Dance, V80, P19
   Delano M, 2007, REM SPEC EDUC, V28, P22
   Giangreco M. F., 2011, INSTRUCTION STUDENTS, P1
   Grandisson M, 2012, J APPL RES INTELLECT, V25, P217, DOI 10.1111/j.1468-3148.2011.00658.x
   Gul SO, 2010, KURAM UYGULAMA EGI, V10, P249
   Haegele J. A., 2010, TEACHING EXCEPTIONAL, V6, P2
   Harle SK, 2001, SPORT PSYCHOL, V15, P289
   Hermansen E, 2007, ED TREATMENT CHILDRE, V30, P183, DOI DOI 10.1353/ETC.2007.0029
   Hitchcock CH, 2003, REM SPEC EDUC, V24, P36, DOI 10.1177/074193250302400104
   Horn J. A., 2008, INT J BEHAV CONSULTA, V4, P279
   HORNER RD, 1978, J APPL BEHAV ANAL, V11, P189, DOI 10.1901/jaba.1978.11-189
   Kamphaus R. W., 2003, RIAS REYNOLDS INTELL
   Kaufman A. S., 2004, KAUFMAN BRIEF INTELL
   Lieberman L. J., 2011, J PHYS ED RECREATION, V82, P25
   Mechling L., 2005, Journal of Special Education Technology, V20
   Mechling LC, 2009, EDUC TRAIN DEV DISAB, V44, P218
   Mechling LC, 2009, EDUC TRAIN DEV DISAB, V44, P67
   Mechling LC, 2006, J SPEC EDUC, V39, P234, DOI 10.1177/00224669060390040401
   Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x
   Norman J. M., 2001, Journal of Special Education Technology, V16
   Physical Education, MERR WEBST ONL DICT
   Ramdoss S., 2011, J BEHAV ED, V20, P55, DOI 10.1007/s10864-010-9112-7
   Rayner C, 2009, RES AUTISM SPECT DIS, V3, P291, DOI 10.1016/j.rasd.2008.09.001
   Sancho K., 2010, EDUC TREAT CHILD, V33, P421, DOI DOI 10.1353/ETC.0.0097
   Sheppard L, 2011, REM SPEC EDUC, V32, P393, DOI 10.1177/0741932510362223
   Shukla-Mehta S, 2010, FOCUS AUTISM DEV DIS, V25, P23, DOI 10.1177/1088357609352901
   Sigafoos J., 2007, J BEHAV ED, V16, P93, DOI DOI 10.1007/S10864-006-9004-Z
   Sigafoos J., 2005, J BEHAV ED, V14, P189, DOI DOI 10.1007/S10864-00506297-2
   Taber-Doughty T, 2011, EDUC TRAIN AUTISM DE, V46, P499
   Van Laarhoven T, 2006, EDUC TRAIN DEV DISAB, V41, P365
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Wehmeyer M. L., 2011, HDB ADOLESCENT TRANS
   Westling D. L., 2008, SPECIAL ED TODAYS TE
   Wissick C. A., 1999, CAREER DEV EXCEPTION, V22, P233, DOI 10.1177/088572889902200206
   Woodward J, 1997, REV EDUC RES, V67, P503, DOI 10.3102/00346543067004503
   Zisimopoulos D, 2011, EDUC TRAIN AUTISM DE, V46, P238
NR 46
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD SEP
PY 2014
VL 49
IS 3
BP 354
EP 367
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AN0XH
UT WOS:000340306800002
ER

PT J
AU Pennington, RC
   Collins, BC
   Stenhoff, DM
   Turner, K
   Gunselman, K
AF Pennington, Robert C.
   Collins, Belva C.
   Stenhoff, Donald M.
   Turner, Kennedy
   Gunselman, Karen
TI Using Simultaneous Prompting and Computer-Assisted Instruction to Teach
   Narrative Writing Skills to Students with Autism
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID LEARNING-DISABLED STUDENTS; OF-THE-LITERATURE; NO CHILD LEFT;
   DEVELOPMENTAL-DISABILITIES; ASPERGER-SYNDROME; PLANNING INSTRUCTION;
   SPECTRUM DISORDERS; WRITTEN; ADOLESCENTS; PERFORMANCE
AB Despite the importance of written expression to the lives of individuals with autism spectrum disorders (ASD), there is limited research on teaching writing skills to this population. In the current study, we used a multiple probe across behaviors design to evaluate the effects of simultaneous prompting (SP) and computer-assisted instruction (CAI) on the story writing responses of five males with autism, 6 to 10 years of age. The data indicated that SP and CAI were effective in improving the story writing skills of all five participants. In addition, all participants increased non-targeted reading skills, the use of novel response forms, and demonstrated at least partial maintenance and generalization of story writing skills.
C1 [Pennington, Robert C.] Univ Louisville, Louisville, KY 40292 USA.
   [Collins, Belva C.] Univ Kentucky, Lexington, KY 40506 USA.
   [Stenhoff, Donald M.] Bista Autism Ctr, Phoenix, AZ USA.
   [Turner, Kennedy; Gunselman, Karen] Jefferson Cty Publ Sch, Lakewood, CO USA.
RP Pennington, RC (reprint author), Univ Louisville, Coll Educ & Human Dev, Dept Special Educ, Louisville, KY 40292 USA.
EM robert.pennington@louisville.edu
CR Akmanoglu N, 2004, EDUC TRAIN DEV DISAB, V39, P326
   Asaro K, 2009, INTERV SCH CLIN, V44, P268, DOI 10.1177/1053451208330895
   Asaro-Saddler K, 2010, EXCEPT CHILDREN, V77, P107
   Basil C., 2003, CHILD LANG TEACH THE, V19, P27, DOI [10.1191/0265659003ct242oa, DOI 10.1191/0265659003CT242OA]
   Bedrosian J, 2003, TOP LANG DISORD, V23, P305
   Bird EKR, 2008, J SPEECH LANG HEAR R, V51, P436, DOI 10.1044/1092-4388(2008/032)
   Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
   Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
   Colozzi GA, 2008, EDUC TRAIN DEV DISAB, V43, P226
   Cornoldi C., 2008, J LEARNING DISABILIT, V41, P435
   COX BE, 1990, READ RES QUART, V25, P47, DOI 10.2307/747987
   Delano M. F., 2007, FOCUS AUTISM OTHER D, V22, P252, DOI DOI 10.1177/10883576070220040701
   Delano ME, 2007, J APPL BEHAV ANAL, V40, P345, DOI 10.1901/jaba.2007.50-06
   DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
   Didden R, 2000, J APPL BEHAV ANAL, V33, P317, DOI 10.1901/jaba.2000.33-317
   Englert CS, 2007, LEARN DISABILITY Q, V30, P9
   Gabig CS, 2008, LANG SPEECH HEAR SER, V39, P498, DOI 10.1044/0161-1461(2008/07-0023)
   GIBSON AN, 1992, TOP EARLY CHILD SPEC, V12, P247
   Goddard Y. L., 2008, READ WRIT Q, V24, P408, DOI 10.1080/10573560802004514
   GRAHAM S, 1989, EXCEPT CHILDREN, V56, P201
   Harris K. R., 2001, LEARNING DISABILITIE, V16, P74, DOI DOI 10.1111/0938-8982.00009
   Hernandez E, 2007, J APPL BEHAV ANAL, V40, P137, DOI 10.1901/jaba.2007.96-05
   Joliffe T., 1999, J AUTISM DEV DISORD, V29, P395
   Joseph LM, 2009, RES DEV DISABIL, V30, P1, DOI 10.1016/j.ridd.2008.01.001
   Kaufman AS, 1983, KAUFMAN ASSESSMENT B
   Kinney EM, 2003, J POSIT BEHAV INTERV, V5, P22, DOI 10.1177/10983007030050010301
   LOVAAS OI, 1971, BEHAV RES THER, V9, P305, DOI 10.1016/0005-7967(71)90042-8
   Mason L. H., 2008, LEARNING DISABILITIE, V23, P103, DOI [10.1111/j.1540-5826.2008.00268.x, DOI 10.1111/J.1540-5826.2008.00268.X]
   Mason LH, 2010, BEHAV DISORDERS, V35, P140
   Mayes SD, 2007, CHILD NEUROPSYCHOL, V13, P469, DOI 10.1080/09297040601112773
   McCarthey SJ, 2008, WRIT COMMUN, V25, P462, DOI 10.1177/0741088308322554
   Mercer C. D., 1998, TEACHING STUDENTS LE
   Morse TE, 2004, EDUC TRAIN DEV DISAB, V39, P153
   Myles BS, 2003, EDUC TRAIN MENT RET, V38, P362
   Newborg J., 1984, BATTELLE DEV INVENTO
   Parker RI, 2009, BEHAV THER, V40, P357, DOI 10.1016/j.beth.2008.10.006
   Pennington R., 2011, ASSIST TECHNOL, V7, P24, DOI DOI 10.1353/ETC.2012.0022
   Pennington RC, 2010, FOCUS AUTISM DEV DIS, V25, P239, DOI 10.1177/1088357610378291
   POPLIN MS, 1980, LEARN DISABILITY Q, V3, P46, DOI 10.2307/1510674
   Saddler B, 2008, J SPEC EDUC, V42, P79, DOI 10.1177/0022466907310371
   Schlosser RW, 1998, J AUTISM DEV DISORD, V28, P309, DOI 10.1023/A:1026060619378
   Schlosser RW, 2004, J SPEECH LANG HEAR R, V47, P848, DOI [10.1044/1092-4388(2004/063), 10.4044/1092-4388(2004/063)]
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Slater J., 1994, PIXWRITER COMPUTER S
   STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
   U. S. Department of Education Institute of Educational Sciences National Center for Education Statistics National Assessment of Educational Progress, 2011, WRIT ASS
   Wakeman SY, 2007, MENT RETARD DEV D R, V13, P143, DOI 10.1002/mrdd.20147
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Yamamoto J, 1999, RES DEV DISABIL, V20, P355, DOI 10.1016/S0891-4222(99)00017-7
NR 49
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD SEP
PY 2014
VL 49
IS 3
BP 396
EP 414
PG 19
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AN0XH
UT WOS:000340306800005
ER

PT J
AU Odluyurt, S
   Tekin-Iftar, E
   Ersoy, G
AF Odluyurt, Serhat
   Tekin-Iftar, Elif
   Ersoy, Gulhan
TI Effects of School Counselor Supervised Peer Tutoring in Inclusive
   Settings on Meeting IEP Outcomes of Students with Developmental
   Disabilities
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID SIGHT WORDS; AUTISM; INSTRUCTION; CHILDREN; SKILLS; INDIVIDUALS;
   BEHAVIORS; ADULTS; TEACH
AB The purpose of this study was to investigate the effects of school counselor supervised peer tutoring intervention on meeting IEP outcomes of six inclusion students with developmental disabilities in a public elementary and secondary school. The effectiveness of this intervention was evaluated by using multiple probe design across students. Elementary school students (3rd graders) were taught purchasing skill at school canteen and the secondary level students (7th and 8th graders) were taught first-aid skill. Three typical peers served as tutors for each student. The results showed that the school counselor successfully supervised peer tutoring intervention, the tutor reliably delivered intervention to their peers with developmental disabilities, and tutees acquired, maintained and generalized the skills on their IEPs. In addition, tutees reported positive opinions regarding the social validity of the study. Results, future research, and implications for practice are discussed.
C1 [Odluyurt, Serhat; Tekin-Iftar, Elif] Anadolu Univ, TR-26470 Eskisehir, Turkey.
   [Ersoy, Gulhan] Barbaros Primary Sch, Kutahya, Turkey.
RP Tekin-Iftar, E (reprint author), Anadolu Univ, Engelliler Arastirma Enstitusu, TR-26470 Eskisehir, Turkey.
EM eltekin@anadolu.edu.tr
CR Akmanoglu N, 2004, EDUC TRAIN DEV DISAB, V39, P326
   Akmanoglu-Uludag N, 2005, EDUC TRAIN DEV DISAB, V40, P401
   BARBETTA PM, 1993, J APPL BEHAV ANAL, V26, P111, DOI 10.1901/jaba.1993.26-111
   Batu S., 2009, EDUC TRAIN DEV DISAB, V43, P541
   BILLINGSLEY F, 1980, BEHAV ASSESS, V2, P229
   Bolich B., 2001, INT J SPECIAL ED, V16, P16
   Cochran L., 1993, BEHAV DISORDERS, V18, P292
   Collins B. C., 2007, MODERATE SEVERE DISA
   COLLINS BC, 1995, EDUC TRAIN MENT RET, V30, P65
   Fetko KS, 1999, EDUC TRAIN MENT RET, V34, P318
   Fickel K. M., 1998, J BEHAV ED, V8, P219, DOI 10.1023/A:1022887624824
   Gardner R, 2001, REM SPEC EDUC, V22, P22, DOI 10.1177/074193250102200104
   Gearheart B. R., 1992, EXCEPTIONAL STUDENTS
   Greenwood C. R., 1991, SPECIAL ED PRACTICAL
   GREENWOOD CR, 1984, J APPL BEHAV ANAL, V17, P521, DOI 10.1901/jaba.1984.17-521
   Harrower J. K., 1999, J POSIT BEHAV INTERV, V1, P215, DOI 10.1177/109830079900100404
   Johnson P., 1996, J BEHAV ED, V6, P437, DOI 10.1007/BF02110516
   Klavina A, 2008, ADAPT PHYS ACT Q, V25, P132
   Kurt O, 2008, TOP EARLY CHILD SPEC, V28, P53, DOI 10.1177/0271121408316046
   Maciag KG, 2000, EDUC TRAIN MENT RET, V35, P306
   MARTELLA RC, 1995, BEHAV MODIF, V19, P170, DOI 10.1177/01454455950192002
   MCGEE GG, 1992, J APPL BEHAV ANAL, V25, P117, DOI 10.1901/jaba.1992.25-117
   Olson J. L., 2000, TEACHING CHILDREN AD
   Parrot K. A., 2000, J BEHAV ED, V10, P3, DOI 10.1023/A:1016639721684
   PIERCE K, 1995, J APPL BEHAV ANAL, V28, P285, DOI 10.1901/jaba.1995.28-285
   Ramps D., 1989, ED TREATMENT CHILDRE, V12, P38
   Riesen T., 2003, J BEHAV ED, V12, P241, DOI DOI 10.1023/A:1026076406656
   Schuster J. W., 1993, J BEHAV ED, V3, P299, DOI 10.1007/BF00961557
   Schuster J. W., 1992, J BEHAVIORAL ED, V2, P305, DOI 10.1007/BF00948820
   Sewell TJ, 1998, J EARLY INTERVENTION, V21, P132
   SINGLETON KC, 1995, EDUC TRAIN MENT RET, V30, P218
   STAUB D, 1993, EXCEPT CHILDREN, V60, P41
   Stettner-Eaton B. A., 1985, ED TRAINING MENTALLY, V20, P61
   Tawney J. W., 1984, SINGLE SUBJECT RES S
   Tekin-Iftar E., 2008, INT J SPECIAL ED, V23, P147
   Tekin-Iftar E, 2003, EDUC TRAIN MENT RET, V38, P77
   Tekin-Iftar E., 2006, OZEL EGITIMDE YANLIS, V2nd
   Tekin E, 2002, EDUC TRAIN MENT RET, V37, P283
   Tekin-Iftar E, 2008, EDUC TRAIN DEV DISAB, V43, P249
   Tekin-Iftar E., 2003, INT J DISABIL DEV ED, V50, P149, DOI 10.1080/1034912032000089657
   Telecsan B. L., 1999, J BEHAV ED, V9, P133, DOI 10.1023/A:1022841001198
   Topping K. J., 1998, PAIRED MATHS HDB PAR
   Turkoglu K. Y., 2007, THESIS ANADOLU U ESK
   Utley C. A., 1998, ED STUDENTS MILD DIS, P339
   Van Norman RK, 2008, REM SPEC EDUC, V29, P96, DOI 10.1177/0741932507311634
   Werts M. G., 1995, J BEHAV ED, V5, P55, DOI 10.1007/BF02110214
   Wolery M., 1994, J BEHAV ED, V4, P415, DOI 10.1007/BF01539542
   Wolery M., 1993, EARLY EDUC DEV, V4, P20, DOI 10.1207/s15566935eed0401_2
NR 48
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD SEP
PY 2014
VL 49
IS 3
BP 415
EP 428
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AN0XH
UT WOS:000340306800006
ER

PT J
AU Pescosolido, MF
   Schwede, M
   Harrison, AJ
   Schmidt, M
   Gamsiz, ED
   Chen, WS
   Donahue, JP
   Shur, N
   Jerskey, BA
   Phornphutkul, C
   Morrow, EM
AF Pescosolido, Matthew F.
   Schwede, Matthew
   Harrison, Ashley Johnson
   Schmidt, Michael
   Gamsiz, Ece D.
   Chen, Wendy S.
   Donahue, John P.
   Shur, Natasha
   Jerskey, Beth A.
   Phornphutkul, Chanika
   Morrow, Eric M.
TI Expansion of the clinical phenotype associated with mutations in
   activity-dependent neuroprotective protein
SO JOURNAL OF MEDICAL GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; DE-NOVO MUTATIONS; GENES; ADNP
C1 [Pescosolido, Matthew F.; Schwede, Matthew; Schmidt, Michael; Gamsiz, Ece D.; Morrow, Eric M.] Dept Mol Biol Cell Biol & Biochem, Providence, RI USA.
   [Pescosolido, Matthew F.] Brown Univ, Mol Med Lab, Inst Brain Sci, Providence, RI 02912 USA.
   [Pescosolido, Matthew F.; Harrison, Ashley Johnson; Gamsiz, Ece D.; Jerskey, Beth A.; Morrow, Eric M.] Brown Univ, Emma Pendleton Bradley Hosp, Dev Disorders Genet Res Program, East Providence, RI USA.
   [Pescosolido, Matthew F.; Harrison, Ashley Johnson; Gamsiz, Ece D.; Jerskey, Beth A.; Morrow, Eric M.] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, East Providence, RI USA.
   [Pescosolido, Matthew F.; Harrison, Ashley Johnson; Schmidt, Michael; Gamsiz, Ece D.; Jerskey, Beth A.; Morrow, Eric M.] Rhode Isl Consortium Autism Res & Treatment RI CA, Providence, RI USA.
   [Chen, Wendy S.; Donahue, John P.] Brown Univ, Dept Surg, Alpert Med Sch, Div Ophthalmol, Providence, RI 02912 USA.
   [Shur, Natasha] Albany Med Ctr, Childrens Hosp, Div Genet, Dept Pediat, Albany, NY USA.
   [Phornphutkul, Chanika] Rhode Isl Hosp, Div Human Genet, Dept Pediat, Providence, RI USA.
   [Phornphutkul, Chanika] Brown Univ, Providence, RI 02912 USA.
RP Morrow, EM (reprint author), Brown Univ, Mol Med Lab, 70 Ship St, Providence, RI 02912 USA.
EM eric_morrow@brown.edu
FU Burroughs Wellcome Fund; NIH NIGMS [P20GM103645]; Simons Foundation
   (SFARI) [239834, 286756]; Nancy Lurie Marks Foundation; Brown Institute
   for Brain Science (BIBS); Norman Prince Neuroscience Institute (NPNI)
FX EMM has received a Career Award in Medical Science from the Burroughs
   Wellcome Fund and support from NIH NIGMS P20GM103645. This work was
   supported by grants from the Simons Foundation (SFARI #239834 & #286756
   to EMM) and also generous support to EMM from the Nancy Lurie Marks
   Foundation. Brown Institute for Brain Science (BIBS) and Norman Prince
   Neuroscience Institute (NPNI).
CR Bassan M, 1999, J NEUROCHEM, V72, P1283, DOI 10.1046/j.1471-4159.1999.0721283.x
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Helsmoortel C, 2014, NAT GENET, V46, P380, DOI 10.1038/ng.2899
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Mandel S, 2007, DEV BIOL, V303, P814, DOI 10.1016/j.ydbio.2006.11.039
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   Pinhasov A, 2003, DEV BRAIN RES, V144, P83, DOI 10.1016/S0165-3806(03)00162-7
   Piton A, 2013, AM J HUM GENET, V93, P368, DOI 10.1016/j.ajhg.2013.06.013
   Vulih-Shultzman I, 2007, J PHARMACOL EXP THER, V323, P438, DOI 10.1124/jpet.107.129551
   Zamostiano R, 2001, J BIOL CHEM, V276, P708
NR 11
TC 1
Z9 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-2593
EI 1468-6244
J9 J MED GENET
JI J. Med. Genet.
PD SEP
PY 2014
VL 51
IS 9
BP 587
EP 589
DI 10.1136/jmedgenet-2014-102444
PG 3
WC Genetics & Heredity
SC Genetics & Heredity
GA AN0AE
UT WOS:000340242400004
PM 25057125
ER

PT J
AU Rasmussen, MB
   Nielsen, JV
   Loureno, CM
   Melo, JB
   Halgren, C
   Geraldi, CVL
   MarquesJr, W
   Rodrigues, GR
   Thomassen, M
   Bak, M
   Hansen, C
   Ferreira, SI
   Venancio, M
   Henriksen, KF
   Lind-Thomsen, A
   Carreira, IM
   Jensen, NA
   Tommerup, N
AF Rasmussen, Malene B.
   Nielsen, Jakob V.
   Loureno, Charles M.
   Melo, Joana B.
   Halgren, Christina
   Geraldi, Camila V. L.
   Marques, Wilson, Jr.
   Rodrigues, Guilherme R.
   Thomassen, Mads
   Bak, Mads
   Hansen, Claus
   Ferreira, Susana I.
   Venancio, Margarida
   Henriksen, Karen F.
   Lind-Thomsen, Allan
   Carreira, Isabel M.
   Jensen, Niels A.
   Tommerup, Niels
TI Neurodevelopmental disorders associated with dosage imbalance of ZBTB20
   correlate with the morbidity spectrum of ZBTB20 candidate target genes
SO JOURNAL OF MEDICAL GENETICS
LA English
DT Article
ID 3Q13.31 MICRODELETION; DEVELOPMENTAL DELAY; PREPULSE INHIBITION; NEURON
   DEVELOPMENT; AUTISM RESEARCH; DATABASE; RESOURCE; TRANSCRIPTION;
   HIPPOCAMPUS; PHENOTYPE
AB Background Recently, a number of patients have been described with structural rearrangements at 3q13.31, delineating a novel microdeletion syndrome with common clinical features including developmental delay and other neurodevelopmental disorders (NDD). A smallest region of overlapping deletions (SRO) involved five RefSeq genes, including the transcription factor gene ZBTB20 and the dopamine receptor gene DRD3, considered as candidate genes for the syndrome.
   Methods and results We used array comparative genomic hybridization and next-generation mate-pair sequencing to identify key structural rearrangements involving ZBTB20 in two patients with NDD. In a patient with developmental delay, attention-deficit hyperactivity disorder, psychosis, Tourette's syndrome and autistic traits, a de novo balanced t(3; 18) translocation truncated ZBTB20. The other breakpoint did not disrupt any gene. In a second patient with developmental delay and autism, we detected the first microdeletion at 3q13.31, which truncated ZBTB20 but did not involve DRD3 or the other genes within the previously defined SRO. Zbtb20 directly represses 346 genes in the developing murine brain. Of the 342 human orthologous ZBTB20 candidate target genes, we found 68 associated with NDD. Using chromatin immunoprecipitation and quantitative PCR, we validated the in vivo binding of Zbtb20 in evolutionary conserved regions in six of these genes (Cntn4, Gad1, Nrxn1, Nrxn3, Scn2a, Snap25).
   Conclusions Our study links dosage imbalance of ZBTB20 to a range of neurodevelopmental, cognitive and psychiatric disorders, likely mediated by dysregulation of multiple ZBTB20 target genes, and provides new knowledge on the genetic background of the NDD seen in the 3q13.31 microdeletion syndrome.
C1 [Rasmussen, Malene B.; Halgren, Christina; Bak, Mads; Hansen, Claus; Henriksen, Karen F.; Lind-Thomsen, Allan; Tommerup, Niels] Univ Copenhagen, Wilhelm Johannsen Ctr Funct Genome Res, Dept Cellular & Mol Med, Fac Hlth Sci, DK-2200 Copenhagen N, Denmark.
   [Nielsen, Jakob V.; Jensen, Niels A.] Univ Southern Denmark, Inst Mol Med, Dept Neurobiol Res, Odense C, Denmark.
   [Loureno, Charles M.; Marques, Wilson, Jr.; Rodrigues, Guilherme R.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Neurogenet Unit, BR-14049 Ribeirao Preto, Brazil.
   [Melo, Joana B.; Carreira, Isabel M.] Univ Coimbra, Lab Citogenet & Genom, Coimbra, Portugal.
   [Melo, Joana B.; Carreira, Isabel M.] Univ Coimbra, CIMAGO, Fac Med, Coimbra, Portugal.
   [Thomassen, Mads] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense C, Denmark.
   [Ferreira, Susana I.] Univ Coimbra, Fac Med, Lab Clin & Genet, Coimbra, Portugal.
   [Venancio, Margarida] Ctr Hosp & Univ Coimbra, Serv Genet Med, Coimbra, Portugal.
   [Venancio, Margarida] Univ Coimbra, Fac Med, Coimbra, Portugal.
RP Tommerup, N (reprint author), Univ Copenhagen, Wilhelm Johannsen Ctr Funct Genome Res, Dept Cellular & Mol Med, Fac Hlth Sci, Blegdamsvej 3,24-4-30, DK-2200 Copenhagen N, Denmark.
EM ntommerup@sund.ku.dk
RI Melo, Joana/K-8347-2014; Marques, Wilson/G-4240-2012
OI Melo, Joana/0000-0001-5049-2670; Marques, Wilson/0000-0002-4589-2749
FU Lundbeck Foundation; Augustinus Foundation; Aase & Ejnar Danielsen's
   Foundation; Faculty of Health Sciences, University of Copenhagen
FX This study was supported by grants from the Lundbeck Foundation, the
   Augustinus Foundation and Aase & Ejnar Danielsen's Foundation and from
   the Faculty of Health Sciences, University of Copenhagen.
CR Banerjee-Basu S, 2010, DIS MODEL MECH, V3, P133, DOI 10.1242/dmm.005439
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Becker KG, 2004, NAT GENET, V36, P431, DOI 10.1038/ng0504-431
   Bugge M, 2000, J MED GENET, V37, P858, DOI 10.1136/jmg.37.11.858
   Bairoch A, 2009, NUCLEIC ACIDS RES, V37, pD169, DOI 10.1093/nar/gkn664
   Cooper S, 1995, CLIN USE INTERPRETAT
   Davies MN, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-4-r56
   Franceschini A, 2013, NUCLEIC ACIDS RES, V41, pD808, DOI 10.1093/nar/gks1094
   Frezal J, 1998, CR ACAD SCI III-VIE, V321, P805, DOI 10.1016/S0764-4469(99)80021-3
   Gimelli S, 2013, MOL CYTOGENET, V6, DOI 10.1186/1755-8166-6-52
   Griffith R, 1970, ABILITIES YOUNG CHIL
   Group WMGRS, 2006, ACTA PAEDIATR, V450, P76
   Grummer-Strawn Laurence M., 2010, Morbidity and Mortality Weekly Report, V59, P1
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Hubbard TJP, 2009, NUCLEIC ACIDS RES, V37, pD690, DOI 10.1093/nar/gkn828
   Jia P, 2010, MOL PSYCHIATR, V15, P453, DOI 10.1038/mp.2009.93
   Kasprzyk A, 2011, DATABASE-OXFORD, V2011, DOI DOI 10.1093/DATABASE/BAR049
   Kleinjan Dirk-Jan, 2009, Briefings in Functional Genomics & Proteomics, V8, P317, DOI 10.1093/bfgp/elp022
   Kou Y, 2012, AM J MED GENET C, V160C, P130, DOI 10.1002/ajmg.c.31330
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lowther C, 2014, MOL CYTOGENET, V7, DOI 10.1186/1755-8166-7-23
   Matuszek G, 2009, BMC MED GENET, V10, DOI 10.1186/1471-2350-10-102
   McKusick-Nathans Institute of Genetic Medicine JHUB MD, 2014, ONL MEND INH MAN OM
   Medina I, 2010, NUCLEIC ACIDS RES, V38, pW210, DOI 10.1093/nar/gkq388
   Mikhail FM, 2011, AM J MED GENET A, V155A, P2386, DOI 10.1002/ajmg.a.34177
   Mitchelmore C, 2002, J BIOL CHEM, V277, P7598, DOI 10.1074/jbc.M110023200
   Molin AM, 2012, J MED GENET, V49, P104, DOI 10.1136/jmedgenet-2011-100534
   Mühlfriedel Sven, 2007, Eur J Neurosci, V26, P33, DOI 10.1111/j.1460-9568.2007.05639.x
   Nazaryan L, 2014, EUR J HUM GENET, V22, P338, DOI 10.1038/ejhg.2013.147
   Nielsen JV, 2010, CEREB CORTEX, V20, P1904, DOI 10.1093/cercor/bhp261
   Nielsen JV, 2007, DEVELOPMENT, V134, P1133, DOI 10.1242/dev.000265
   Nielsen JV, 2014, CEREB CORTEX, V24, P1216, DOI 10.1093/cercor/bhs400
   PERRY A, 1989, J AUTISM DEV DISORD, V19, P41, DOI 10.1007/BF02212717
   Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025
   Petryshen TL, 2005, GENETICS, V171, P1895, DOI 10.1534/genetics.105.045658
   Rosenthal EH, 2012, HIPPOCAMPUS, V22, P2144, DOI 10.1002/hipo.22035
   Safran M, 2010, DATABASE-OXFORD, V2010, DOI DOI 10.1093/DATABASE/BAQ020
   Schienkiewitz A, 2011, ACTA PAEDIATR, V100, pe28, DOI 10.1111/j.1651-2227.2011.02173.x
   Shuvarikov A, 2013, HUM MUTAT, V34, P1415, DOI 10.1002/humu.22384
   Swerdlow NR, 2013, NEUROSCI BIOBEHAV R, V37, P1150, DOI 10.1016/j.neubiorev.2012.09.002
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Visel A, 2009, NATURE, V457, P854, DOI 10.1038/nature07730
   Vuillaume ML, 2013, MOL GENET METAB, V110, P90, DOI 10.1016/j.ymgme.2013.07.013
   Wisniowiecka-Kowalnik B, 2013, EUR J HUM GENET, V21, P620, DOI 10.1038/ejhg.2012.219
   Xie Z, 2008, P NATL ACAD SCI USA, V105, P10859, DOI 10.1073/pnas.0800647105
   Xie ZF, 2010, P NATL ACAD SCI USA, V107, P6510, DOI 10.1073/pnas.0912315107
   Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
   Yu W, 2008, NAT GENET, V40, P124, DOI 10.1038/ng0208-124
   Zhang LY, 2012, NUCLEIC ACIDS RES, V40, pD1003, DOI 10.1093/nar/gkr992
   Zhang WP, 2001, BIOCHEM BIOPH RES CO, V282, P1067, DOI 10.1006/bbrc.2001.4689
NR 50
TC 1
Z9 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-2593
EI 1468-6244
J9 J MED GENET
JI J. Med. Genet.
PD SEP
PY 2014
VL 51
IS 9
BP 605
EP U6613
DI 10.1136/jmedgenet-2014-102535
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA AN0AE
UT WOS:000340242400007
PM 25062845
ER

PT J
AU Furlong, MA
   Engel, SM
   Barr, DB
   Wolff, MS
AF Furlong, Melissa A.
   Engel, Stephanie M.
   Barr, Dana Boyd
   Wolff, Mary S.
TI Prenatal exposure to organophosphate pesticides and reciprocal social
   behavior in childhood
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Social Responsiveness Scale; Organophosphate pesticides; Environmental
   exposures; Neurodevelopment
ID NEONATAL CHLORPYRIFOS EXPOSURE; MEXICAN-AMERICAN CHILDREN; AUTISM
   SPECTRUM DISORDER; IN-UTERO; SEROTONERGIC MECHANISMS; BRAIN-DEVELOPMENT;
   YOUNG-CHILDREN; FETAL-GROWTH; NEURODEVELOPMENT; POPULATION
AB Prenatal exposure to organophosphate pesticides (OPs) has been associated with adverse neurodevelopmental outcomes in childhood, including low IQ pervasive developmental disorder (PDD), attention problems and ADHD. Many of these disorders involve impairments in social functioning. Thus, we investigated the relationship between biomarkers of prenatal OP exposure and impaired reciprocal social behavior in childhood, as measured by the Social Responsiveness Scale (SRS). Using a multi-ethnic urban prospective cohort of mother-infant pairs in New York City recruited between 1998 and 2002 (n = 404) we examined the relation between third trimester maternal urinary levels of dialkylphosphate (Sigma DAP) OP metabolites and SRS scores among 136 children who returned for the 7-9 year visit. Overall, there was no association between OPs and SRS scores, although in multivariate adjusted models, associations were heterogeneous by race and by sex. Among blacks, each 10-fold increase in total diethylphosphates (Sigma DEP) was associated with poorer social responsiveness (beta = 5.1 points, 95% confidence interval (CI) 0.8, 9.4). There was no association among whites or Hispanics, or for total ZDAP or total dimethylphosphate (Sigma DMP) biomarker levels. Additionally, stratum-specific models supported a stronger negative association among boys for Sigma DEPs (beta = 3.5 points, 95% CI 02, 6.8), with no notable association among girls. Our results support an association of prenatal OP exposure with deficits in social functioning among blacks and among boys, although this may be in part reflective of differences in exposure patterns. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Furlong, Melissa A.; Engel, Stephanie M.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA.
   [Barr, Dana Boyd] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Wolff, Mary S.] Mt Sinai Sch Med, Dept Prevent Med, New York, NY USA.
RP Furlong, MA (reprint author), Univ N Carolina, Box 7435, Chapel Hill, NC 27599 USA.
EM furlongm@med.unc.edu
CR Aldridge JE, 2005, ENVIRON HEALTH PERSP, V113, P527, DOI 10.1289/ehp.7867
   Aldridge JE, 2005, ENVIRON HEALTH PERSP, V113, P1027, DOI 10.1289/ehp.7968
   Baio J., 2012, PREVALENCE AUTISM SP
   Barr DB, 2011, INT J ENV RES PUB HE, V8, P3063, DOI 10.3390/ijerph8083063
   Berkowitz GS, 2003, ENVIRON HEALTH PERSP, V111, P79, DOI 10.1289/ehp.5619
   Berkowitz GS, 2004, ENVIRON HEALTH PERSP, V112, P388, DOI 10.1289/ehp.6414
   Bouchard MF, 2011, ENVIRON HEALTH PERSP, V119, P1189, DOI 10.1289/ehp.1003185
   Bravo R, 2004, J EXPO ANAL ENV EPID, V14, P249, DOI 10.1038/sj.jea.7500322
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Dam K, 2003, BRAIN RES BULL, V59, P261, DOI 10.1016/S0361-9230(02)00874-2
   Engel SM, 2007, AM J EPIDEMIOL, V165, P1397, DOI 10.1093/aje/kwm029
   Engel SM, 2011, ENVIRON HEALTH PERSP, V119, P1182, DOI 10.1289/ehp.1003183
   Eskenazi B, 2010, ENVIRON HEALTH PERSP, V118, P1775, DOI 10.1289/ehp.1002234
   Eskenazi B, 2007, ENVIRON HEALTH PERSP, V115, P792, DOI 10.1289/ehp.9828
   Eskenazi B, 2004, ENVIRON HEALTH PERSP, V112, P1116, DOI 10.1289/ehp.6789
   Eskenazi B., 2003, J CHILD HLTH, V1, P3
   Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
   Julvez J, 2009, PAEDIATR PERINAT EP, V23, P199, DOI 10.1111/j.1365-3016.2009.01032.x
   Krain AL, 2006, CLIN PSYCHOL REV, V26, P433, DOI 10.1016/j.cpr.2006.01.005
   Landrigan PJ, 1999, ANN NY ACAD SCI, V895, P1, DOI 10.1111/j.1749-6632.1999.tb08073.x
   Marks AR, 2010, ENVIRON HEALTH PERSP, V118, P1768, DOI 10.1289/ehp.1002056
   Middlemore-Risher ML, 2010, NEUROTOXICOL TERATOL, V32, P415, DOI 10.1016/j.ntt.2010.03.008
   Perera FP, 2002, ENVIRON HEALTH PERSP, V110, P197
   Pine DS, 2008, J AM ACAD CHILD PSY, V47, P652, DOI 10.1097/CHI.0b013e31816bffa5
   Qiao D, 2003, ENVIRON HEALTH PERSP, V111, P536, DOI 10.1289/ehp.5828
   Rauch SA, 2012, ENVIRON HEALTH PERSP, V120, P1055, DOI 10.1289/ehp.1104615
   Rauh V, 2011, ENVIRON HEALTH PERSP, V119, P1196, DOI 10.1289/ehp.1003160
   Rauh VA, 2012, P NATL ACAD SCI USA, V109, P7871, DOI 10.1073/pnas.1203396109
   Rauh VA, 2006, PEDIATRICS, V118, pE1845, DOI 10.1542/peds.2006-0338
   Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
   Ricceri L, 2006, TOXICOL SCI, V93, P105
   Rothman K, 2008, MODERN EPIDEMIOLOGY, V3rd
   Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
   Slotkin TA, 2005, DEV BRAIN RES, V158, P115, DOI 10.1016/j.devbrainres.2005.06.008
   Slotkin TA, 2008, ENVIRON HEALTH PERSP, V116, P1308, DOI 10.1289/ehp.11451
   Sparks BF, 2002, NEUROLOGY, V59, P184
   Stout DM, 2009, ENVIRON SCI TECHNOL, V43, P4294, DOI 10.1021/es8030243
   SULTATOS LG, 1994, J TOXICOL ENV HEALTH, V43, P271
   Thier AL, 1998, PLAGUED PESTICIDES A
   Thyagarajan B, 2008, CLIN CHEM, V54, P738, DOI 10.1373/clinchem.2007.099044
   Venerosi A, 2010, PSYCHOPHARMACOLOGY, V208, P99, DOI 10.1007/s00213-009-1713-2
   Visser SB, 2010, MORBIDITY MORTALITY
   Weng HY, 2009, AM J EPIDEMIOL, V169, P1182, DOI 10.1093/aje/kwp035
   Whyatt RM, 2005, TOXICOL APPL PHARM, V206, P246, DOI 10.1016/j.taap.2004.11.027
NR 47
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD SEP
PY 2014
VL 70
BP 125
EP 131
DI 10.1016/j.envint.2014.05.011
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AM2PL
UT WOS:000339693200014
PM 24934853
ER

PT J
AU Tunc, B
   Ghanbari, Y
   Smith, AR
   Pandey, J
   Browne, A
   Schultz, RT
   Verma, R
AF Tunc, Birkan
   Ghanbari, Yasser
   Smith, Alex R.
   Pandey, Juhi
   Browne, Aaron
   Schultz, Robert T.
   Verma, Ragini
TI PUNCH: Population Characterization of Heterogeneity
SO NEUROIMAGE
LA English
DT Article
DE Heterogeneity; Autism Spectrum Disorders; Severity measure
ID AUTISM SPECTRUM DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC
   INTERVIEW; CLASSIFICATION; QUESTIONNAIRE; CHILDREN; RDOC; FRAMEWORK;
   CRITERIA; MACHINE
AB Neuropsychiatric disorders are notoriously heterogeneous in their presentation, which precludes straightforward and objective description of the differences between affected and typical populations that therefore makes finding reliable biomarkers a challenge. This difficulty underlines the need for reliable methods to capture sample characteristics of heterogeneity using a single continuous measure, incorporating the multitude of score used to describe different aspects of functioning. This study addresses this challenge by proposing a gener method of identifying and quantifying the heterogeneity of any clinical population using a severity meastn, called the PUNCH (Population Characterization of Heterogeneity). PUNCH is a decision level fusion techniquc to incorporate decisions of various phenotypic scores, while providing interpretable weights for scores. We provide applications of our framework to simulated datasets and to a large sample of youth with Autism Spectrun Disorder (ASD). Next we stratify PUNCH scores in our ASD sample and show how severity moderates findings o group differences in diffusion weighted brain imaging data; more severely affected subgroups of ASD sho) expanded differences compared to age and gender matched healthy controls. Results demonstrate the abilit of our measure in quantifying the underlying heterogeneity of the clinical samples, and suggest its utility in providing researchers with reliable severity assessments incorporating population heterogeneity. (C) 2014 Elsevier Inc. All rights reserved
C1 [Tunc, Birkan; Ghanbari, Yasser; Smith, Alex R.; Verma, Ragini] Univ Penn, Perelman Sch Med, Dept Radiol, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.
   [Pandey, Juhi; Browne, Aaron; Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
   [Schultz, Robert T.] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
   [Schultz, Robert T.] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
RP Verma, R (reprint author), Sect Biomed Image Anal, 3600 Market St,Suite 380, Philadelphia, PA 19104 USA.
EM Ragini.Verma@uphs.upenn.edu
FU National Institutes of Health [NIMH 1RC1MH088791, R01-MH092862,
   R21-MH098010, P30-HD026979]; Pennsylvania Department of Health (SAP)
   [4100042728, 4100047863]
FX This research was supported by grants from National Institutes of Health
   (NIMH 1RC1MH088791 to Robert T. Schultz, P30-HD026979 to M. Yudkoff, and
   R01-MH092862 and R21-MH098010 to Ragini Verma) and grants from the
   Pennsylvania Department of Health (SAP # 4100042728 and SAP #4100047863
   to Robert T. Schultz).
CR Alexander A. L., NEUROIMAGE, V34, P61
   Alpaydin E., 2010, INTRO MACHINE LEARNI
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Birmaher B., 1995, SCREEN CHILD ANXIETY
   Bishop C. M., 2006, PATTERN RECOGNITION
   Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
   Boomsma A, 2008, J CHILD PSYCHOL PSYC, V49, P809, DOI 10.1111/j.1469-7610.2008.01897.x
   Cohen J., 1983, APPL MULTIPLE REGRES, V2nd
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297
   Cuthbert BN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-126
   Cuthbert BN, 2014, WORLD PSYCHIATRY, V13, P28, DOI 10.1002/wps.20087
   DuPaul G.J., 1994, ADHD RATING SC UNPUB
   Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
   Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
   Ecker C, 2010, NEUROIMAGE, V49, P44, DOI 10.1016/j.neuroimage.2009.08.024
   Elliott C., 2007, DIFFERENTIAL ABILITY
   Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083
   Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
   Georgiades S, 2013, J CHILD PSYCHOL PSYC, V54, P206, DOI 10.1111/j.1469-7610.2012.02588.x
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Gioia GA, 2000, BEHAV RATING INVENTO
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
   Ingalhalikar M, 2011, NEUROIMAGE, V57, P918, DOI 10.1016/j.neuroimage.2011.05.023
   Insel T, 2010, AM J PSYCHIAT, V167, P748, DOI 10.1176/appi.ajp.2010.09091379
   Jeste SS, 2014, NAT REV NEUROL, V10, P74, DOI 10.1038/nrneurol.2013.278
   Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6
   Lazarsfeld P., 1968, LATENT STRUCTURE ANA
   Lenroot RK, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00733
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Long S. J., 1997, REGRESSION MODELS CA
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lubke GH, 2005, PSYCHOL METHODS, V10, P21, DOI 10.1037/1082-989X.10.1.21
   Morris Sarah E, 2012, Dialogues Clin Neurosci, V14, P29
   Mourao-Miranda J, 2011, NEUROIMAGE, V58, P793, DOI 10.1016/j.neuroimage.2011.06.042
   Muthen B, 1999, BIOMETRICS, V55, P463, DOI 10.1111/j.0006-341X.1999.00463.x
   Owens JA, 2000, SLEEP, V23, P1043
   Pedregosa F, 2011, J MACH LEARN RES, V12, P2825
   Rasmussen CE, 2005, ADAPT COMPUT MACH LE, P1
   Snow AV, 2009, J CHILD PSYCHOL PSYC, V50, P734, DOI 10.1111/j.1469-7610.2008.02018.x
   Sparrow S.S., 2007, VINELAND ADAPTIVE BE
   Sui Jing, 2012, Front Hum Neurosci, V6, P27, DOI 10.3389/fnhum.2012.00027
   Sui J, 2012, J NEUROSCI METH, V204, P68, DOI 10.1016/j.jneumeth.2011.10.031
   Veatch O.J., 2011, GENES BRAIN BEHAV, V13, P276
   Wakana S, 2004, RADIOLOGY, V230, P77, DOI 10.1148/radiol.2301021640
NR 47
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
EI 1095-9572
J9 NEUROIMAGE
JI Neuroimage
PD SEP
PY 2014
VL 98
BP 50
EP 60
DI 10.1016/j.neuroimage.2014.04.068
PG 11
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AM2UQ
UT WOS:000339706700006
PM 24799135
ER

PT J
AU Meaux, E
   Taylor, MJ
   Pang, EW
   Vara, AS
   Batty, M
AF Meaux, Emilie
   Taylor, Margot J.
   Pang, Elizabeth W.
   Vara, Anjili S.
   Batty, Magali
TI Neural Substrates of Numerosity Estimation in Autism
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE numerosity estimation; local and global perception; autism; MEG
ID MENTAL NUMBER LINE; POSTERIOR PARIETAL CORTEX; PRIMATE PREFRONTAL
   CORTEX; HIGH-FUNCTIONING AUTISM; VOXEL-BASED MORPHOMETRY; VISUAL
   WORKING-MEMORY; MEDIAL TEMPORAL-LOBE; INTRAPARIETAL SULCUS;
   ELECTROPHYSIOLOGICAL EVIDENCE; PERCEIVED NUMEROSITY
AB Visual skills, including numerosity estimation are reported to be superior in autism spectrum disorders (ASD). This phenomenon is attributed to individuals with ASD processing local features, rather than the Gestalt. We examined the neural correlates of numerosity estimation in adults with and without ASD, to disentangle perceptual atypicalities from numerosity processing. Fourteen adults with ASD and matched typically developed (TD) controls estimated the number of dots (80-150) arranged either randomly (local information) or in meaningful patterns (global information) while brain activity was recorded with magnetoencephalography (MEG). Behavioral results showed no significant group difference in the errors of estimation. However, numerical estimation in ASD was more variable across numerosities than TD and was not affected by the global arrangement of the dots. At 80-120 ms, MEG analyses revealed early significant differences (TD>ASD) in source amplitudes in visual areas, followed from 120 to 400 ms by group differences in temporal, and then parietal regions. After 400 ms, a source was found in the superior frontal gyrus in TD only. Activation in temporal areas was differently sensitive to the global arrangement of dots in TD and ASD. MEG data show that individuals with autism exhibit widespread functional abnormalities. Differences in temporal regions could be linked to atypical global perception. Occipital followed by parietal and frontal differences might be driven by abnormalities in the processing and conversion of visual input into a number-selective neural code and complex cognitive decisional stages. These results suggest overlapping atypicalities in sensory, perceptual and number-related processing during numerosity estimation in ASD. Hum Brain Mapp 35:4362-4385, 2014. (C) 2014 Wiley Periodicals, Inc.
C1 [Meaux, Emilie] Univ Med Ctr, Dept Neurosci & Clin Neurol, Lab Neurol & Imaging Cognit, Geneva, Switzerland.
   [Taylor, Margot J.; Vara, Anjili S.] Univ Toronto, Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5S 1A1, Canada.
   [Taylor, Margot J.; Vara, Anjili S.] Univ Toronto, Dept Psychol & Med Imaging, Toronto, ON M5S 1A1, Canada.
   [Pang, Elizabeth W.] Univ Toronto, Hosp Sick Children, Div Neurol, Toronto, ON M5S 1A1, Canada.
   [Batty, Magali] Univ Tours, CHRU Tours, Ctr Pedopsychiat, INSERM,U930,UMR Imagerie & Cerveau, F-37000 Tours, France.
RP Meaux, E (reprint author), Univ Med Ctr, Dept Neurosci & Clin Neurol, Lab Neurol & Imaging Cognit, Geneva, Switzerland.
EM Emilie.Meaux@unige.ch
FU CIHR [MOP-81161]; SickKids Hospital of Toronto; Planiol Fundation;
   BRIDGE Fellowship of the Marie Curie Foundation
FX Contract grant sponsor: CIHR; Contract grant number: MOP-81161; Contract
   grant sponsor: SickKids Hospital of Toronto; Contract grant sponsor:
   Planiol Fundation; Contract grant sponsor: BRIDGE Fellowship of the
   Marie Curie Foundation
CR Abu Bakar A, 2008, HUM BRAIN MAPP, V29, P1313, DOI 10.1002/hbm.20464
   Albrecht K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073531
   Almeida RA, 2010, NEUROPSYCHOLOGIA, V48, P374, DOI 10.1016/j.neuropsychologia.2009.09.024
   Almeida RA, 2010, NEUROPSYCHOLOGIA, V48, P4117, DOI 10.1016/j.neuropsychologia.2010.10.009
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Andres M, 2005, COGNITIVE BRAIN RES, V25, P283, DOI 10.1016/j.cogbrainres.2005.06.002
   Ansari D, 2006, BRAIN RES, V1067, P181, DOI 10.1016/j.brainres.2005.10.083
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Arsalidou M, 2011, NEUROIMAGE, V54, P2382, DOI 10.1016/j.neuroimage.2010.10.009
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Barthelemy C, 1995, AUTISME ENFANT THERA
   Batty M, 2011, J EXP CHILD PSYCHOL, V109, P430, DOI 10.1016/j.jecp.2011.02.001
   Beaucousin V, 2011, NEUROPSYCHOLOGIA, V49, P1258, DOI 10.1016/j.neuropsychologia.2011.01.039
   Berger A, 2011, DEV NEUROPSYCHOL, V36, P668, DOI 10.1080/87565641.2010.549878
   Booth JL, 2006, DEV PSYCHOL, V42, P189, DOI 10.1037/0012-1649.41.6.189
   Brannon EM, 1998, SCIENCE, V282, P746, DOI 10.1126/science.282.5389.746
   Brock J, 2011, PERCEPTION, V40, P739, DOI 10.1068/p6953
   Brodeur M, 2006, BRAIN RES, V1068, P143, DOI 10.1016/j.brainres.2005.10.064
   BRYSBAERT M, 1995, J EXP PSYCHOL GEN, V124, P434, DOI 10.1037//0096-3445.124.4.434
   Burbaud P, 1999, NEUROSCI LETT, V273, P195, DOI 10.1016/S0304-3940(99)00641-2
   Burr D, 2008, CURR BIOL, V18, P425, DOI 10.1016/j.cub.2008.02.052
   Butterworth B, 1999, MATH BRAIN
   Cabeza R, 2008, NAT REV NEUROSCI, V9, P613, DOI 10.1038/nrn2459
   Cantlon JF, 2009, TRENDS COGN SCI, V13, P83, DOI 10.1016/j.tics.2008.11.007
   Cantlon JF, 2006, PLOS BIOL, V4, P844, DOI 10.1371/journal.pbio.0040125
   Cantrell L, 2013, COGNITION, V126, P258, DOI 10.1016/j.cognition.2012.10.007
   Cappelletti M, 2007, EXP BRAIN RES, V179, P631, DOI 10.1007/s00221-006-0820-0
   Caron MJ, 2004, NEUROPSYCHOLOGIA, V42, P467, DOI 10.1016/j.neuropsychologia.2003.08.015
   Castelli F, 2006, P NATL ACAD SCI USA, V103, P4693, DOI 10.1073/pnas.0600444103
   Castronovo J, 2007, Q J EXP PSYCHOL, V60, P101, DOI 10.1080/17470210600598635
   Castronovo J, 2007, J EXP PSYCHOL HUMAN, V33, P1089, DOI 10.1037/0096-1523.33.5.1089
   CAVADA C, 1989, J COMP NEUROL, V287, P422, DOI 10.1002/cne.902870403
   Cavanna AE, 2006, BRAIN, V129, P564, DOI 10.1093/brain/awl004
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   Cheyne D, 2006, HUM BRAIN MAPP, V27, P213, DOI 10.1002/hbm.20178
   Chochon F, 1999, J COGNITIVE NEUROSCI, V11, P617, DOI 10.1162/089892999563689
   Chong SC, 2011, WIRES COGN SCI, V2, P634, DOI 10.1002/wcs.136
   CIPOLOTTI L, 1991, BRAIN, V114, P2619, DOI 10.1093/brain/114.6.2619
   Conci M, 2011, NEUROPSYCHOLOGIA, V49, P2456, DOI 10.1016/j.neuropsychologia.2011.04.023
   Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755
   Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
   Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794
   Crollen V, 2011, EXP PSYCHOL, V58, P39, DOI 10.1027/1618-3169/a000064
   Crollen V, 2013, CORTEX, V49, P276, DOI 10.1016/j.cortex.2011.11.006
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   DEHAENE S, 1993, J EXP PSYCHOL GEN, V122, P371, DOI 10.1037/0096-3445.122.3.371
   Dehaene S, 1996, NEUROPSYCHOLOGIA, V34, P1097, DOI 10.1016/0028-3932(96)00027-9
   Dehaene S., 1997, NUMBER SENSE MIND CR
   DEHAENE S, 1992, COGNITION, V44, P1, DOI 10.1016/0010-0277(92)90049-N
   Dehaene S, 1996, J COGNITIVE NEUROSCI, V8, P47, DOI 10.1162/jocn.1996.8.1.47
   Dehaene S, 1999, SCIENCE, V284, P970, DOI 10.1126/science.284.5416.970
   Dehaene S, 1997, CORTEX, V33, P219, DOI 10.1016/S0010-9452(08)70002-9
   Dehaene S, 2004, CURR OPIN NEUROBIOL, V14, P218, DOI 10.1016/j.conb.2004.03.008
   Dehaene S, 2003, COGN NEUROPSYCHOL, V20, P487, DOI 10.1080/02643290244000239
   de Hevia MD, 2008, NEUROSCI BIOBEHAV R, V32, P1361, DOI 10.1016/j.neubiorev.2008.05.015
   Demeyere N, 2012, J COGNITIVE NEUROSCI, V24, P948, DOI 10.1162/jocn_a_00188
   den Ouden HEM, 2005, NEUROIMAGE, V28, P787, DOI 10.1016/j.neuroimage.2005.05.001
   Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026
   Dormal V, 2008, CORTEX, V44, P462, DOI 10.1016/j.cortex.2007.08.011
   Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
   Faillenot I, 1999, NEUROIMAGE, V10, P114, DOI 10.1006/nimg.1999.0449
   Feigenson L, 2004, TRENDS COGN SCI, V8, P307, DOI 10.1016/j.tics.2004.05.002
   Fias W, 2004, TRENDS COGN SCI, V8, P447, DOI 10.1016/j.tics.2004.08.009
   Fias W, 1996, MATH COGNITION, V2, P95, DOI DOI 10.1080/135467996387552
   Fias W, 2003, J COGNITIVE NEUROSCI, V15, P47, DOI 10.1162/089892903321107819
   Fink GR, 2001, NEUROIMAGE, V13, P46, DOI 10.1006/nimg.2000.0673
   Fischer M. H., 2005, HDB MATH COGNITION, P43
   Frith U, 1989, EXPLAINING ENIGMA
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Fulbright RK, 2003, AM J NEURORADIOL, V24, P193
   GALLISTEL CR, 1992, COGNITION, V44, P43, DOI 10.1016/0010-0277(92)90050-R
   Gallistel CR, 2000, TRENDS COGN SCI, V4, P59, DOI 10.1016/S1364-6613(99)01424-2
   Gebuis T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037426
   Gelman R, 2004, SCIENCE, V306, P441, DOI 10.1126/science.1105144
   Gerlach C, 2000, NEUROPSYCHOLOGIA, V38, P1693, DOI 10.1016/S0028-3932(00)00082-8
   Gerstmann J, 1940, ARCH NEURO PSYCHIATR, V44, P398
   Gilboa A, 2005, HIPPOCAMPUS, V15, P535, DOI 10.1002/hipo.20090
   Goffaux V, 2012, NEUROPSYCHOLOGIA, V50, P3419, DOI 10.1016/j.neuropsychologia.2012.09.046
   Grandin T, 2009, BIOL PSYCHIAT, V65, P15, DOI 10.1016/j.biopsych.2008.11.005
   GREENHOUSE SW, 1959, PSYCHOMETRIKA, V24, P95, DOI 10.1007/BF02289823
   Grinter EJ, 2009, J AUTISM DEV DISORD, V39, P1278, DOI 10.1007/s10803-009-0740-5
   GRUNE K, 1993, NEUROREPORT, V4, P1272, DOI 10.1097/00001756-199309000-00016
   Hagmann P, 2008, PLOS BIOL, V6, P1479, DOI 10.1371/journal.pbio.0060159
   Halgren E, 2003, NEUROIMAGE, V18, P1001, DOI 10.1016/S1053-8119(03)00045-4
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe FGE, 2008, Q J EXP PSYCHOL, V61, P50, DOI 10.1080/17470210701508731
   Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
   Happe FGE, 1997, BRIT J DEV PSYCHOL, V15, P1
   Hari R, 2010, ANN NY ACAD SCI, V1191, P89, DOI 10.1111/j.1749-6632.2010.05438.x
   Hayashi MJ, 2013, J NEUROSCI, V33, P883, DOI 10.1523/JNEUROSCI.6257-11.2013
   Heaton P, 2004, J CHILD PSYCHOL PSYC, V45, P899, DOI 10.1111/j.1469-7610.2004.t01-1-00284.x
   HECAEN H., 1961, REV NEUROL [PARIS], V105, P85
   Heine A, 2011, NEUROPSYCHOLOGIA, V49, P3238, DOI 10.1016/j.neuropsychologia.2011.07.028
   Henschen SL, 1919, Z GESAMTE NEUROL PSY, V52, P273, DOI 10.1007/BF02872428
   Herrmann CS, 2001, NEUROREPORT, V12, P901, DOI 10.1097/00001756-200104170-00007
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   HOLLINGSWORTH WH, 1991, B PSYCHONOMIC SOC, V29, P448
   Hubbard EM, 2005, NAT REV NEUROSCI, V6, P435, DOI 10.1038/nrn1684
   Huberle E, 2012, BRAIN STRUCT FUNCT, V217, P735, DOI 10.1007/s00429-011-0369-y
   Huntley-Fenner G, 2000, PSYCHOL SCI, V11, P147, DOI 10.1111/1467-9280.00230
   Hyde DC, 2011, J COGNITIVE NEUROSCI, V23, P2336, DOI 10.1162/jocn.2010.21581
   Hyde DC, 2009, J COGNITIVE NEUROSCI, V21, P1039, DOI 10.1162/jocn.2009.21090
   Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
   Izard V, 2008, COGNITION, V106, P1221, DOI 10.1016/j.cognition.2007.06.004
   Izard Véronique, 2008, PLoS Biol, V6, pe11, DOI 10.1371/journal.pbio.0060011
   Jemel B, 2010, J VISION, V10, DOI 10.1167/10.6.13
   Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kadosh RC, 2005, NEUROPSYCHOLOGIA, V43, P1238, DOI 10.1016/j.neuropsychologia.2004.12.017
   Kadosh RC, 2007, J COGNITIVE NEUROSCI, V19, P957, DOI 10.1162/jocn.2007.19.6.957
   Kaldy Z, 2011, DEVELOPMENTAL SCI, V14, P980, DOI 10.1111/j.1467-7687.2011.01053.x
   Karmiloff-Smith A, 2012, P NATL ACAD SCI USA, V109, P1
   KAUFMAN EL, 1949, AM J PSYCHOL, V62, P498, DOI 10.2307/1418556
   Kaufmann L, 2005, NEUROIMAGE, V25, P888, DOI 10.1016/j.neuroimage.2004.12.041
   Kaufmann L, 2008, DEVELOPMENTAL SCI, V11, P692, DOI 10.1111/j.1467-7687.2008.00718.x
   Kiefer M., 1997, MATH COGNITION, V3, P1
   Knauff M, 2003, J COGNITIVE NEUROSCI, V15, P559, DOI 10.1162/089892903321662949
   Knops A, 2009, SCIENCE, V324, P1583, DOI 10.1126/science.1171599
   Knops A, 2009, ATTEN PERCEPT PSYCHO, V71, P803, DOI 10.3758/APP.71.4.803
   Koten JW, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00115
   Kreiman G, 2000, NAT NEUROSCI, V3, P946
   KRUEGER LE, 1984, PERCEPT PSYCHOPHYS, V35, P536, DOI 10.3758/BF03205949
   KRUEGER LE, 1972, PERCEPT PSYCHOPHYS, V11, P5, DOI 10.3758/BF03212674
   Latinus M, 2006, BRAIN RES, V1123, P179, DOI 10.1016/j.brainres.2006.09.031
   Leichnetz GR, 2001, ANAT RECORD, V263, P215, DOI 10.1002/ar.1082
   Lelord G, 1990, NEUROPSYCHIAT ENFAN, V38, P43
   Lerner Y, 2001, CEREB CORTEX, V11, P287, DOI 10.1093/cercor/11.4.287
   Libertus ME, 2007, BEHAV BRAIN FUNCT, V3, DOI 10.1186/1744-9081-3-1
   Lipton JS, 2005, CHILD DEV, V76, P978, DOI 10.1111/j.1467-8624.2005.00891.x
   Liu YN, 2011, NEUROPSYCHOLOGIA, V49, P2105, DOI 10.1016/j.neuropsychologia.2011.04.005
   Lou HC, 2004, P NATL ACAD SCI USA, V101, P6827, DOI 10.1073/pnas.0400049101
   Luck SJ, 1997, NATURE, V390, P279, DOI 10.1038/36846
   Lundstrom BN, 2005, NEUROIMAGE, V27, P824, DOI 10.1016/j.neuroimage.2005.05.008
   Mace MJM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005927
   Mak-Fan KM, 2013, AUTISM, V17, P541, DOI 10.1177/1362361312442596
   MANDLER G, 1982, J EXP PSYCHOL GEN, V111, P1, DOI 10.1037/0096-3445.111.1.1
   Marco EJ, 2011, PEDIATR RES, V69, p48R, DOI [10.1203/PDR.0b013e3182130c54, 10.1109/SPL.2011.5782616]
   Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
   Martinez A, 2007, J NEUROSCI, V27, P7963, DOI 10.1523/JNEUROSCI.0031-07.2007
   Meintjes EM, 2010, ALCOHOL CLIN EXP RES, V34, P1450, DOI 10.1111/j.1530-0277.2010.01230.x
   Menon V, 2000, NEUROIMAGE, V12, P357, DOI 10.1006/nimg.2000.0613
   Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
   Minshew NJ, 2002, MOL PSYCHIATR, V7, pS14, DOI 10.1038/sj.mp.4001166
   Minturn AL, 1951, J PSYCHOL, V31, P201
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Mottron L, 2009, PHILOS T R SOC B, V364, P1385, DOI 10.1098/rstb.2008.0333
   Murray MM, 2004, J NEUROSCI, V24, P6898, DOI 10.1523/JNEUROSCI.1996-04.2004
   Murray MM, 2002, J NEUROSCI, V22, P5055
   Nan Y, 2006, NEUROPSYCHOLOGIA, V44, P1103, DOI 10.1016/j.neuropsychologia.2005.10.020
   Newcombe NS, 2002, PSYCHOL SCI, V13, P395, DOI 10.1111/1467-9280.00471
   Nieder A, 2004, P NATL ACAD SCI USA, V101, P7457, DOI 10.1073/pnas.0402239101
   Nieder A, 2002, SCIENCE, V297, P1708, DOI 10.1126/science.1072493
   Nieder A, 2003, NEURON, V37, P149, DOI 10.1016/S0896-6273(02)01144-3
   Nieder A, 2009, ANNU REV NEUROSCI, V32, P185, DOI 10.1146/annurev.neuro.051508.135550
   O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
   Pagano S, 2012, NEUROPSYCHOLOGIA, V50, P754, DOI 10.1016/j.neuropsychologia.2012.01.009
   Pesenti M, 2000, J COGNITIVE NEUROSCI, V12, P461, DOI 10.1162/089892900562273
   Piazza M, 2004, NEURON, V44, P547, DOI 10.1016/j.neuron.2004.10.014
   Piazza M, 2007, NEURON, V53, P293, DOI 10.1016/j.neuron.2006.11.022
   Piazza M, 2011, COGNITION, V121, P147, DOI 10.1016/j.cognition.2011.05.007
   Pinel P, 2004, NEURON, V41, P983, DOI 10.1016/S0896-6273(04)00107-2
   Pinel P, 2001, NEUROIMAGE, V14, P1013, DOI 10.1006/nimg.2001.0913
   PYLYSHYN Z, 1989, COGNITION, V32, P65, DOI 10.1016/0010-0277(89)90014-0
   Quiroga RQ, 2005, NATURE, V435, P1102, DOI 10.1038/nature03687
   Quraan MA, 2011, HUM BRAIN MAPP, V32, P812, DOI 10.1002/hbm.21068
   Rousselet GA, 2002, NAT NEUROSCI, V5, P629, DOI 10.1038/nn866
   Rusconi E, 2011, CORTEX, V47, P2, DOI 10.1016/j.cortex.2009.08.005
   Rusconi E, 2007, COGN NEUROPSYCHOL, V24, P373, DOI 10.1080/02643290701309425
   Russell-Smith SN, 2012, J AUTISM DEV DISORD, V42, P2420, DOI 10.1007/s10803-012-1506-z
   Sacks Oliver, 1985, MAN WHO MISTOOK HIS
   Sanchez-Marin FJ, 2008, J AUTISM DEV DISORD, V38, P1270, DOI 10.1007/s10803-007-0507-9
   Santens S, 2010, CEREB CORTEX, V20, P77, DOI 10.1093/cercor/bhp080
   Sawamura H, 2002, NATURE, V415, P918, DOI 10.1038/415918a
   Schmidt BK, 2002, PERCEPT PSYCHOPHYS, V64, P754, DOI 10.3758/BF03194742
   Sekihara K, 2001, IEEE T BIO-MED ENG, V48, P760, DOI 10.1109/10.930901
   SELEMON LD, 1988, J NEUROSCI, V8, P4049
   Shafritz KM, 2002, P NATL ACAD SCI USA, V99, P10917, DOI 10.1073/pnas.152694799
   Simon TJ, 1997, COGNITIVE DEV, V12, P349, DOI 10.1016/S0885-2014(97)90008-3
   Simon TJ, 1999, TRENDS COGN SCI, V3, P363, DOI 10.1016/S1364-6613(99)01383-2
   Simos PG, 2008, NEUROPSYCHOLOGY, V22, P571, DOI 10.1037/0894-4105.22.5.571
   Smith S. B., 1983, GREAT MENTAL CALCULA
   Soulieres I, 2010, COGN NEUROPSYCHOL, V27, P261, DOI 10.1080/02643294.2010.519228
   Xu F, 2000, COGNITION, V74, pB1, DOI 10.1016/S0010-0277(99)00066-9
   Stanescu-Cosson R, 2000, BRAIN, V123, P2240, DOI 10.1093/brain/123.11.2240
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   Suchan B, 2002, BEHAV BRAIN RES, V131, P163, DOI 10.1016/S0166-4328(01)00373-4
   Swartz W, 1998, NEUROPSYCHOLOGIA, V36, P1167
   Szucs D, 2008, BRAIN RES, V1190, P143, DOI 10.1016/j.brainres.2007.11.010
   Szucs D, 2005, NEUROSCI LETT, V384, P11, DOI 10.1016/j.neulet.2005.04.050
   Temple E, 1998, P NATL ACAD SCI USA, V95, P7836, DOI 10.1073/pnas.95.13.7836
   THOMPSON RF, 1970, SCIENCE, V168, P271, DOI 10.1126/science.168.3928.271
   TRICK LM, 1994, PSYCHOL REV, V101, P80, DOI 10.1037//0033-295X.101.1.80
   Trick LM, 1992, NATURE ORIGINS MATH, P257
   Turconi E, 2004, COGNITIVE BRAIN RES, V21, P22, DOI 10.1016/j.cogbraines.2004.05.003
   Tzur G, 2010, PSYCHOPHYSIOLOGY, V47, P758, DOI 10.1111/j.1469-8986.2010.00967.x
   Uddin LQ, 2010, CEREB CORTEX, V20, P2636, DOI 10.1093/cercor/bhq011
   Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321
   Van Herwegen J, 2008, DEVELOPMENTAL SCI, V11, P637, DOI 10.1111/j.1467-7687.2008.00711.x
   Verguts T, 2004, J COGNITIVE NEUROSCI, V16, P1493, DOI 10.1162/0898929042568497
   Verguts T, 2005, PSYCHON B REV, V12, P66, DOI 10.3758/BF03196349
   Vrba J, 2001, METHODS, V25, P249, DOI 10.1003/meth.2001.1238
   Vuokko E, 2013, BRAIN RES, V1497, P40, DOI 10.1016/j.brainres.2012.12.019
   Walsh V, 2003, TRENDS COGN SCI, V7, P483, DOI 10.1016/j.tics.2003.09.002
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weissman DH, 2005, CEREB CORTEX, V15, P870, DOI 10.1093/cercor/bhh187
   Whalen J, 1999, PSYCHOL SCI, V10, P130, DOI 10.1111/1467-9280.00120
   Zago L, 2001, NEUROIMAGE, V13, P314, DOI 10.1006/nimg.2000.0697
NR 209
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD SEP
PY 2014
VL 35
IS 9
BP 4362
EP 4385
DI 10.1002/hbm.22480
PG 24
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AM0VZ
UT WOS:000339567000008
PM 24639374
ER

PT J
AU Romano, D
   Nicolau, M
   Quintin, EM
   Mazaika, PK
   Lightbody, AA
   Hazlett, HC
   Piven, J
   Carlsson, G
   Reiss, AL
AF Romano, David
   Nicolau, Monica
   Quintin, Eve-Marie
   Mazaika, Paul K.
   Lightbody, Amy A.
   Hazlett, Heather Cody
   Piven, Joseph
   Carlsson, Gunnar
   Reiss, Allan L.
TI Topological Methods Reveal High and Low Functioning Neuro-Phenotypes
   Within Fragile X Syndrome
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE autism spectrum behavior; MRI; topological data analysis; multivariate
   pattern analysis; voxel-based morphometry
ID IMAGE-ANALYSIS; AUTISM; BOYS; DISORDERS; THRESHOLD; SPECTRUM
AB Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability as well as the most common single-gene risk factor for autism. Our goal was to examine variation in brain structure in FXS with topological data analysis (TDA), and to assess how such variation is associated with measures of IQ and autism-related behaviors. To this end, we analyzed imaging and behavioral data from young boys (n = 52; aged 1.57-4.15 years) diagnosed with FXS. Application of topological methods to structural MRI data revealed two large subgroups within the study population. Comparison of these subgroups showed significant between-subgroup neuroanatomical differences similar to those previously reported to distinguish children with FXS from typically developing controls (e. g., enlarged caudate). In addition to neuroanatomy, the groups showed significant differences in IQ and autism severity scores. These results suggest that despite arising from a single gene mutation, FXS may encompass two biologically, and clinically separable phenotypes. In addition, these findings underscore the potential of TDA as a powerful tool in the search for biological phenotypes of neuropsychiatric disorders. (C) 2014 Wiley Periodicals, Inc.
C1 [Romano, David; Quintin, Eve-Marie; Mazaika, Paul K.; Lightbody, Amy A.; Reiss, Allan L.] Stanford Univ, Sch Med, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA.
   [Nicolau, Monica; Carlsson, Gunnar] Stanford Univ, Dept Math, Stanford, CA 94305 USA.
   [Hazlett, Heather Cody; Piven, Joseph] UNC, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
RP Romano, D (reprint author), Stanford Univ, 401 Quarry Rd,Rm 1356,MC 5795, Stanford, CA 94305 USA.
EM dromano@stanford.edu
FU National Institute of Mental Health [R01MH050047, R01MH064708,
   R01MH064580, MH061696, 5T32MH019908]; National Institute of Child Health
   and Human Development [P30HD003110]; Canel Family Fund
FX Contract grant sponsor: National Institute of Mental Health; Contract
   grant numbers: R01MH050047, R01MH064708, R01MH064580; MH061696,
   5T32MH019908; Contract grant sponsor: National Institute of Child Health
   and Human Development; Contract grant number: P30HD003110; Contract
   grant sponsor: the Canel Family Fund.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Ascano M, 2012, NATURE, V492, P382, DOI 10.1038/nature11737
   Bray S, 2009, FRONT HUM NEUROSCI, V3, P30
   Brock M, 2010, J INTELL DISABIL RES, V54, P894, DOI 10.1111/j.1365-2788.2010.01315.x
   Brunberg JA, 2002, AM J NEURORADIOL, V23, P1757
   Calhoun VD, 2012, TRENDS COGN SCI, V16, P255, DOI 10.1016/j.tics.2012.03.008
   Carlsson G, 2009, B AM MATH SOC, V46, P255
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Fair DA, 2012, P NATL ACAD SCI USA, V109, P6769, DOI 10.1073/pnas.1115365109
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gothelf D, 2005, NAT NEUROSCI, V8, P1500, DOI 10.1038/nn1572
   Hazlett HC, 2012, J AM ACAD CHILD PSY, V51, P921, DOI 10.1016/j.jaac.2012.07.003
   Hoeft F, 2011, ARCH GEN PSYCHIAT, V68, P295, DOI 10.1001/archgenpsychiatry.2010.153
   Hoeft F, 2008, ARCH GEN PSYCHIAT, V65, P1087, DOI 10.1001/archpsyc.65.9.1087
   Hoeft F, 2010, P NATL ACAD SCI USA, V107, P9335, DOI 10.1073/pnas.1002762107
   Jacquemont S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001708
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lum PY, 2013, SCI REP-UK, V3, DOI 10.1038/srep01236
   Nicolau M, 2011, P NATL ACAD SCI USA, V108, P7265, DOI 10.1073/pnas.1102826108
   Pereira F, 2009, NEUROIMAGE, V45, pS199, DOI 10.1016/j.neuroimage.2008.11.007
   Schindelin J, 2012, NAT METHODS, V9, P676, DOI [10.1038/nmeth.2019, 10.1038/NMETH.2019]
   Schmid B, 2010, BMC BIOINFORMATICS, V11
   Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
   Smith SM, 2009, NEUROIMAGE, V44, P83, DOI 10.1016/j.neuroimage.2008.03.061
   Wolff JJ, 2012, J AM ACAD CHILD PSY, V51, P1324, DOI 10.1016/j.jaac.2012.09.001
NR 26
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD SEP
PY 2014
VL 35
IS 9
BP 4904
EP 4915
DI 10.1002/hbm.22521
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AM0VZ
UT WOS:000339567000048
PM 24737721
ER

PT J
AU de Rosnay, M
   Fink, E
   Begeer, S
   Slaughter, V
   Peterson, C
AF de Rosnay, Marc
   Fink, Elian
   Begeer, Sander
   Slaughter, Virginia
   Peterson, Candida
TI Talking theory of mind talk: young school-aged children's everyday
   conversation and understanding of mind and emotion
SO JOURNAL OF CHILD LANGUAGE
LA English
DT Article
ID FALSE-BELIEF; INDIVIDUAL-DIFFERENCES; AUTISM-SPECTRUM; LANGUAGE;
   BEHAVIOR; DEAFNESS; METAANALYSIS; TEMPERAMENT; SKILLS
AB Links between young children's everyday use of mindful conversational skills and their success on laboratory tests of theory of mind understanding (ToM) were evaluated. Using published scales, teachers rated the conversational behavior and shyness of 129 children aged 60 to 101 months (M=78.8 months) who were in their first years of primary school. The children also took batteries of first-and second-order false-belief tests along with tests of emotion understanding and general language ability. Correlational and regression analyses showed that performance on false-belief tests of ToM significantly predicted children's competence at reading others' minds in their everyday conversational interactions. Furthermore, these links transcended individual differences in language ability, shy personality, emotion understanding, and age. These findings augment and extend a growing body of evidence linking performance on laboratory ToM tests to socially competent real-world behavior.
C1 [de Rosnay, Marc; Fink, Elian; Begeer, Sander] Univ Sydney, Sydney, NSW 2006, Australia.
   [Begeer, Sander] Vrije Univ Amsterdam, Amsterdam, Netherlands.
   [Slaughter, Virginia; Peterson, Candida] Univ Queensland, Brisbane, Qld 4072, Australia.
RP Peterson, C (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
EM candi@psy.uq.edu.au
CR Astington J. W., 2005, WHY LANGUAGE MATTERS
   ASTINGTON JW, 1995, COGNITION EMOTION, V9, P151, DOI 10.1080/02699939508409006
   Astington JW, 1999, DEV PSYCHOL, V35, P1311, DOI 10.1037//0012-1649.35.5.1311
   Banerjee R, 2001, SOC DEV, V10, P558, DOI 10.1111/1467-9507.00180
   Bernstein B., 1996, CHILDREN RES POLICY, P81
   BRINTON B, 1984, J SPEECH HEAR RES, V27, P350
   Deleau M, 2012, EUR J DEV PSYCHOL, V9, P295, DOI 10.1080/17405629.2012.680303
   de Rosnay M, 2006, BRIT J DEV PSYCHOL, V24, P7, DOI 10.1348/02615005X82901
   DORVAL B, 1984, MONOGR SOC RES CHILD, V49, P1, DOI 10.2307/1165872
   Dunn L., 2007, MANUAL PEABODY PICTU
   Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X
   Gresham F. M., 1990, SOCIAL SKILLS RATING
   Harris P. L., 2005, WHY LANGUAGE MATTERS, P70
   Hughes C, 2004, SOC DEV, V13, P590, DOI 10.1111/j.1467-9507.2004.00285.x
   LALONDE CE, 1995, COGNITION EMOTION, V9, P167, DOI 10.1080/02699939508409007
   Lane JD, 2013, DEV PSYCHOL, V49, P825, DOI 10.1037/a0028825
   Milligan K, 2007, CHILD DEV, V78, P622, DOI 10.1111/j.1467-8624.2007.01018.x
   PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7
   Peskin J, 2003, SOC DEV, V12, P496, DOI 10.1111/1467-9507.00245
   Peterson CC, 2009, EUR CHILD ADOLES PSY, V18, P105, DOI 10.1007/s00787-008-0711-y
   Peterson CC, 2005, CHILD DEV, V76, P502, DOI 10.1111/j.1467-8624.2005.00859.x
   Peterson CC, 2009, SCAND J PSYCHOL, V50, P475, DOI 10.1111/j.1467-9450.2009.00750.x
   PETERSON CC, 1995, J CHILD PSYCHOL PSYC, V36, P459, DOI 10.1111/j.1469-7610.1995.tb01303.x
   Peterson CC, 1999, PSYCHOL SCI, V10, P126, DOI 10.1111/1467-9280.00119
   Peterson CC, 2012, CHILD DEV, V83, P469, DOI 10.1111/j.1467-8624.2011.01728.x
   Piaget J., 1926, THE LANGUAGE AND THO
   Pons F, 2004, EUR J DEV PSYCHOL, V1, P127, DOI 10.1080/17405620344000022
   Pons F, 2005, COGNITION EMOTION, V19, P1158, DOI 10.1080/02699930500282108
   Ruffman T, 2002, CHILD DEV, V73, P734, DOI 10.1111/1467-8624.00435
   Sehley S., 1992, SOCIAL DEVELOPMENT, V1, P18, DOI 10.1111/j.1467-9507.1992.tb00132.x
   Slaughter V, 2007, CHILD DEV, V78, P839, DOI 10.1111/j.1467-8624.2007.01036.x
   Slaughter V, 2013, DEV PSYCHOL, V49, P227, DOI 10.1037/a0028280
   Talwar V, 2008, CHILD DEV, V79, P866, DOI 10.1111/j.1467-8624.2008.01164.x
   Walker S, 2005, J GENET PSYCHOL, V166, P297, DOI 10.3200/GNTP.166.3.297-312
   Wellman HM, 2004, CHILD DEV, V75, P523, DOI 10.1111/j.1467-8624.2004.00691.x
   Wellman HM, 2011, DEVELOPMENTAL SCI, V14, P319, DOI 10.1111/j.1467-7687.2010.00977.x
   Wellman HM, 2001, CHILD DEV, V72, P655, DOI 10.1111/1467-8624.00304
NR 37
TC 2
Z9 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0305-0009
EI 1469-7602
J9 J CHILD LANG
JI J. Child Lang.
PD SEP
PY 2014
VL 41
IS 5
BP 1179
EP 1193
DI 10.1017/S0305000913000433
PG 15
WC Psychology, Developmental; Linguistics; Psychology, Experimental
SC Psychology; Linguistics
GA AM0PR
UT WOS:000339548200009
PM 24229511
ER

PT J
AU Pedersen, L
   Parlar, S
   Kvist, K
   Whiteley, P
   Shattock, P
AF Pedersen, Lennart
   Parlar, Sarah
   Kvist, Kajsa
   Whiteley, Paul
   Shattock, Paul
TI Data mining the ScanBrit study of a gluten- and casein-free dietary
   intervention for children with autism spectrum disorders: Behavioural
   and psychometric measures of dietary response
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Autism spectrum disorder; Dietary intervention; Gluten; Casein
ID URINARY INDOLYL-3-ACRYLOYLGLYCINE; RISK; MUTATIONS
AB We previously reported results based on the examination of a gluten- and casein-free diet as an intervention for children diagnosed with an autism spectrum disorder as part of the ScanBrit collaboration. Analysis based on grouped results indicated several significant differences between dietary and non-dietary participants across various core and peripheral areas of functioning. Results also indicated some disparity in individual responses to dietary modification potentially indicative of responder and non-responder differences. Further examination of the behavioural and psychometric data garnered from participants was undertaken, with a view to determining potential factors pertinent to response to dietary intervention. Participants with clinically significant scores indicative of inattention and hyperactivity behaviours and who had a significant positive changes to said scores were defined as responders to the dietary intervention. Analyses indicated several factors to be potentially pertinent to a positive response to dietary intervention in terms of symptom presentation. Chronological age was found to be the strongest predictor of response, where those participants aged between 7 and 9 years seemed to derive most benefit from dietary intervention. Further analysis based on the criteria for original study inclusion on the presence of the urine compound, trans-indolyl-3-acryloylglycine may also merit further investigation. These preliminary observations on potential best responder characteristics to a gluten-and casein-free diet for children with autism require independent replication.
C1 [Pedersen, Lennart; Parlar, Sarah] Ctr Autisme, DK-2730 Herlev, Denmark.
   [Kvist, Kajsa] PFA Pens, DK-2100 Copenhagen, Denmark.
   [Whiteley, Paul; Shattock, Paul] ESPA Res, BIC, Unit 133i, Sunderland SR5 2TA, England.
RP Pedersen, L (reprint author), Ctr Autisme, Herlev Hovedgade 199, DK-2730 Herlev, Denmark.
EM lpe@centerforautisme.dk
FU Center for Autisme; Nils O. Seim Family Fund for Medical Research; Eric
   Birger Christensen Fond; Norwegian Protein Intolerance Association;
   Robert Luff Foundation; Glashofs Legat
FX The authors thank all the parents who gave their time and permission for
   their children to take part in this difficult study. We owe a huge debt
   of thanks to Maureen Pilvang and Jonna Deibjerg who provided nutritional
   advice and support to parents and Charlotte Mathiesen who provided
   administrative support. The study was supported by grants from the
   Center for Autisme, the Nils O. Seim Family Fund for Medical Research,
   the Eric Birger Christensen Fond, the Norwegian Protein Intolerance
   Association, The Robert Luff Foundation and Glashofs Legat.
CR Adams JB, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-111
   Anderson RJ, 2002, J PHARM PHARMACOL, V54, P295, DOI 10.1211/0022357021778349
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Bull G, 2003, MED SCI MONITOR, V9, pCR422
   Clayton TA, 2012, FEBS LETT, V586, P956, DOI 10.1016/j.febslet.2012.01.049
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   DuPaul GJ, 1998, ADHD RATING SCALE 4
   Fasano A, 2012, CLIN GASTROENTEROL H, V10, P1096, DOI 10.1016/j.cgh.2012.08.012
   Fountain C, 2012, PEDIATRICS, V129, pE1112, DOI 10.1542/peds.2011-1601
   Fujibayashi Hiromi, 2010, Kobe J Med Sci, V56, pE12
   Gilliam J. E., 1995, GILLIAM AUTISM RATIN
   Grafodatskaya D, 2010, J AM ACAD CHILD PSY, V49, P794, DOI 10.1016/j.jaac.2010.05.005
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Kapur S, 2012, MOL PSYCHIATR, V17, P1174, DOI 10.1038/mp.2012.105
   Kohane IS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033224
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Main PAE, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-35
   Novarino G, 2012, SCIENCE, V338, P394, DOI 10.1126/science.1224631
   Reichelt KL, 2003, NUTR NEUROSCI, V6, P19, DOI 10.1080/1028415021000042839
   Schmidt RJ, 2012, AM J CLIN NUTR, V96, P80, DOI 10.3945/ajcn.110.004416
   Sparrow SS, 1984, CIRCLE PINES
   Wang L, 2009, BIOMARKERS, V14, P596, DOI 10.3109/13547500903183962
   Whiteley P, 2010, NUTR NEUROSCI, V13, P87, DOI 10.1179/147683010X12611460763922
   Whiteley P, 2010, AUTISM INSIGHTS, V2, P39
   Wright B, 2005, DEV MED CHILD NEUROL, V47, P190, DOI 10.1017/S0012162205000344
NR 26
TC 1
Z9 1
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD SEP
PY 2014
VL 17
IS 5
BP 207
EP 213
DI 10.1179/1476830513Y.0000000082
PG 7
WC Neurosciences; Nutrition & Dietetics
SC Neurosciences & Neurology; Nutrition & Dietetics
GA AL1DI
UT WOS:000338865600002
PM 24075141
ER

PT J
AU Bernard, PB
   Castano, AM
   Bayer, KU
   Benke, TA
AF Bernard, Paul B.
   Castano, Anna M.
   Bayer, K. Ulrich
   Benke, Tim A.
TI Necessary, but not sufficient: Insights into the mechanisms of mGluR
   mediated long-term depression from a rat model of early life seizures
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Early life seizure; Long-term depression; Metabotropic glutamate
   receptor; CaMKII; Voltage-gated calcium channels; Autism
ID FRAGILE-X-SYNDROME; METABOTROPIC GLUTAMATE RECEPTORS; MENTAL-RETARDATION
   PROTEIN; SIGNALING PATHWAY; MOUSE MODEL; SYNAPTIC PLASTICITY; CAMKII
   AUTONOMY; KINASE; PHOSPHORYLATION; POTENTIATION
AB Using the rat model of early life seizures (ELS), which has exaggerated mGluR mediated long-term depression of synaptic strength (mGluR-LTD) in adulthood, we probed the signaling cascades underlying mGluR-LTD induction. Several inhibitors completely blocked mGluR-LTD in control but not in ELS rats: the proteasome, the mammalian target of rapamycin (mTOR), S6 kinase (S6K), or L-type voltage-gated calcium channels (L-type VGCC). Inhibition of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) resulted in a near complete block of mGluR-LTD in control rats and a slight reduction of mGluR-LTD in ELS rats. "Autonomous" CaMKII was found to be upregulated in ELS rats, while elevated S6K activity, which is stimulated by mTOR, was described previously. Thus, modulation of each of these factors was necessary for mGluR-LTD induction in control rats, but even their combined, permanent activation in the ELS rats was not sufficient to individually support mGluR-LTD induction following ELS. This implies that while these factors may act sequentially in controls to mediate mGluR-LTD, this is no longer the case after ELS. In contrast, activated ERK was found to be significantly down-regulated in ELS rats. Inhibition of MEK/ERK activation in control rats elevated mGluR-LTD to the exaggerated levels seen in ELS rats. Together, these results elucidate both the mechanisms that persistently enhance mGluR-LTD after ELS and the mechanisms underlying normal mGluR-LTD by providing evidence for multiple, convergent pathways that mediate mGluR-LTD induction. With our prior work, this ties these signaling cascades to the ELS behavioral phenotype that includes abnormal working memory, fear conditioning and socialization. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Bernard, Paul B.; Castano, Anna M.; Benke, Tim A.] Univ Colorado, Sch Med, Dept Pediat, Denver, CO 80045 USA.
   [Bayer, K. Ulrich; Benke, Tim A.] Univ Colorado, Sch Med, Neurosci Grad Program, Denver, CO 80045 USA.
   [Benke, Tim A.] Univ Colorado, Sch Med, Dept Neurol, Denver, CO 80045 USA.
   [Bayer, K. Ulrich; Benke, Tim A.] Univ Colorado, Sch Med, Dept Pharmacol, Denver, CO 80045 USA.
   [Benke, Tim A.] Univ Colorado, Sch Med, Dept Otolaiyngol, Denver, CO 80045 USA.
RP Benke, TA (reprint author), Univ Colorado, Sch Med, Dept Pediat, 12800 E 19th,MS8102, Denver, CO 80045 USA.
EM tim.benke@ucdenver.edu
FU Children's Hospital Colorado Research Institute; Epilepsy Foundation;
   National Institutes of Health [R01 NS076577, R01 NS081248]
FX Special thanks to Drs. Heather O'Leary, Mark Dell'Acqua, Steve Coultrap
   and other members of the Benke, Bayer and Dell'Acqua labs and the
   Neuroscience Program Machine Shop Core. Funding provided by the
   Children's Hospital Colorado Research Institute, Epilepsy Foundation,
   and National Institutes of Health grants R01 NS076577 (to T.B.) and R01
   NS081248 (to K.U.B.). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of NINDS
   or NIH.
CR Anderson WW, 2001, J NEUROSCI METH, V108, P71, DOI 10.1016/S0165-0270(01)00374-0
   Banko JL, 2006, J NEUROSCI, V26, P2167, DOI 10.1523/JNEUROSCI.5196-05.2006
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Bernard PB, 2013, NEUROBIOL DIS, V59, P1, DOI 10.1016/j.nbd.2013.06.013
   Bingol B, 2010, CELL, V140, P567, DOI 10.1016/j.cell.2010.01.024
   Buard I, 2010, J NEUROSCI, V30, P8214, DOI 10.1523/JNEUROSCI.1469-10.2010
   Ceman S, 2003, HUM MOL GENET, V12, P3295, DOI 10.1093/hmg/ddg350
   Chevere-Torres I, 2012, NEUROBIOL DIS, V45, P1101, DOI 10.1016/j.nbd.2011.12.028
   Citri A, 2009, EUR J NEUROSCI, V30, P1443, DOI 10.1111/j.1460-9568.2009.06950.x
   Conn PJ, 1997, ANNU REV PHARMACOL, V37, P205, DOI 10.1146/annurev.pharmtox.37.1.205
   Cornejo BJ, 2007, ANN NEUROL, V61, P411, DOI 10.1002/ana.21071
   Cornejo BJ, 2008, EPILEPSY BEHAV, V13, P585, DOI 10.1016/j.yebeh.2008.07.002
   Coultrap SJ, 2011, ACTA PHARMACOL SIN, V32, P861, DOI 10.1038/aps.2011.68
   Coultrap SJ, 2010, J BIOL CHEM, V285, P17930, DOI 10.1074/jbc.M109.069351
   Coultrap SJ, 2012, TRENDS NEUROSCI, V35, P607, DOI 10.1016/j.tins.2012.05.003
   Dingledine R, 1999, PHARMACOL REV, V51, P7
   Djakovic SN, 2009, J BIOL CHEM, V284, P26655, DOI 10.1074/jbc.M109.021956
   Dzhala VI, 2005, NAT MED, V11, P1205, DOI 10.1038/nm1301
   Gallagher SM, 2004, J NEUROSCI, V24, P4859, DOI 10.1523/JNEUROSCI.5407-03.2004
   Gladding CM, 2009, PHARMACOL REV, V61, P395, DOI 10.1124/pr.109.001735
   Grosshans DR, 2001, J NEUROCHEM, V76, P737, DOI 10.1046/j.1471-4159.2001.00034.x
   Hay N, 2004, GENE DEV, V18, P1926, DOI 10.1101/gad.1212704
   Hou LF, 2006, NEURON, V51, P441, DOI 10.1016/j.neuron.2006.07.005
   Hou LF, 2004, J NEUROSCI, V24, P6352, DOI 10.1523/JNEUROSCI.0995-04.2004
   Huber KM, 2000, SCIENCE, V288, P1254, DOI 10.1126/science.288.5469.1254
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Jarome TJ, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00115
   Kemp N, 2000, EUR J NEUROSCI, V12, P360, DOI 10.1046/j.1460-9568.2000.00903.x
   Klann E, 2004, NAT REV NEUROSCI, V5, P931, DOI 10.1038/nrn1557
   Kuenzi FM, 2000, J NEUROSCI METH, V100, P117, DOI 10.1016/S0165-0270(00)00239-9
   Lisman J, 2012, NAT REV NEUROSCI, V13, P169, DOI 10.1038/nrn3192
   Luscher C, 2010, NEURON, V65, P445, DOI 10.1016/j.neuron.2010.01.016
   Malenka RC, 2004, NEURON, V44, P5, DOI 10.1016/j.neuron.2004.09.012
   MALINOW R, 1989, SCIENCE, V245, P862, DOI 10.1126/science.2549638
   MILLER SG, 1986, CELL, V44, P861, DOI 10.1016/0092-8674(86)90008-5
   Mockett BG, 2011, J NEUROSCI, V31, P7380, DOI 10.1523/JNEUROSCI.6656-10.2011
   Moult PR, 2006, J NEUROSCI, V26, P2544, DOI 10.1523/JNEUROSCI.4322-05.2006
   NAKANISHI S, 1994, NEURON, V13, P1031, DOI 10.1016/0896-6273(94)90043-4
   Narayanan U, 2007, J NEUROSCI, V27, P14349, DOI 10.1523/JNEUROSCI.2969-07.2007
   Narayanan U, 2008, J BIOL CHEM, V283, P18478, DOI 10.1074/jbc.C800055200
   Nosyreva ED, 2006, J NEUROPHYSIOL, V95, P3291, DOI 10.1152/jn.01316.2005
   Osterweil EK, 2010, J NEUROSCI, V30, P15616, DOI 10.1523/JNEUROSCI.3888-10.2010
   Paul S, 2003, NAT NEUROSCI, V6, P34, DOI 10.1038/nn989
   Pearce LR, 2010, BIOCHEM J, V431, P245, DOI 10.1042/BJ20101024
   PIN JP, 1995, NEUROPHARMACOLOGY, V34, P1, DOI 10.1016/0028-3908(94)00129-G
   Potter WB, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001627
   RUEGG UT, 1990, DRUGS, V40, P3
   Sarbassov DD, 2005, CURR OPIN CELL BIOL, V17, P596, DOI 10.1016/j.ceb.2005.09.009
   Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
   SILVA AJ, 1992, SCIENCE, V257, P201, DOI 10.1126/science.1378648
   Stefani G, 2004, J NEUROSCI, V24, P7272, DOI 10.1523/JNEUROSCI.2306-04.2004
   Striessnig J, 1998, TRENDS PHARMACOL SCI, V19, P108, DOI 10.1016/S0165-6147(98)01171-7
   Tang SJ, 2002, P NATL ACAD SCI USA, V99, P467, DOI 10.1073/pnas.012605299
   TREMBLAY E, 1984, NEUROSCIENCE, V13, P1051, DOI 10.1016/0306-4522(84)90288-4
   Vest RS, 2007, MOL BIOL CELL, V18, P5024, DOI 10.1091/mbc.E07-02-0185
   Zhang Y, 2008, J NEUROSCI, V28, P10561, DOI 10.1523/JNEUROSCI.2666-08.2008
NR 56
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD SEP
PY 2014
VL 84
SI SI
BP 1
EP 12
DI 10.1016/j.neuropharm.2014.04.011
PG 12
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AK7OC
UT WOS:000338616600001
PM 24780380
ER

PT J
AU Lin, CY
   Chang, YM
AF Lin, Chien-Yu
   Chang, Yu-Ming
TI Increase in physical activities in kindergarten children with cerebral
   palsy by employing MaKey-MaKey-based task systems
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Interaction; Cerebral palsy; MaKey MaKey; Conductive materials;
   Single-case design
ID DESIGNATED OCCUPATIONAL ACTIVITIES; ENVIRONMENTAL STIMULATION; ASSISTING
   PEOPLE; DISABILITIES; REHABILITATION; EXERCISE; LIFE; AUTISM; ADULTS
AB In this study, we employed Flash- and Scratch-based multimedia by using a MaKey-MaKey-based task system to increase the motivation level of children with cerebral palsy to perform physical activities. MaKey MaKey is a circuit board that converts physical touch to a digital signal, which is interpreted by a computer as a keyboard message. In this study, we used conductive materials to control this interaction. This study followed single-case design using ABAB models in which A indicated the baseline and B indicated the intervention. The experiment period comprised 1 month and a half. The experimental results demonstrated that in the case of two kindergarten children with cerebral palsy, their scores were considerably increased during the intervention phrases. The developmental applications of the results are also discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lin, Chien-Yu] Natl Univ Tainan, Dept Special Educ, Tainan 700, Taiwan.
   [Chang, Yu-Ming] Southern Taiwan Univ Sci & Technol, Coll Digital Design, Tainan 710, Taiwan.
RP Lin, CY (reprint author), Natl Univ Tainan, Dept Special Educ, 33,Sect 2,Shu Lin St, Tainan 700, Taiwan.
EM linchienyu@mail.nutn.edu.tw
CR Aron J., 2012, NEW SCI, V214, P22
   Blikstein P., 2013, P 12 INT C INT DES C, P613
   Bonnardel N, 2011, DISPLAYS, V32, P69, DOI 10.1016/j.displa.2010.12.002
   Brennan K., 2013, P 44 ACM TECHN S COM, P463
   Brennan K., 2010, NEW DIRECTIONS YOUTH, V128, P75
   Carvalho PVR, 2008, DISPLAYS, V29, P273, DOI 10.1016/j.displa.2007.08.010
   Chang YJ, 2013, RES DEV DISABIL, V34, P3654, DOI 10.1016/j.ridd.2013.08.021
   Chang YJ, 2011, RES DEV DISABIL, V32, P2566, DOI 10.1016/j.ridd.2011.07.002
   Chou CH, 2012, ARCH PHYS MED REHAB, V93, P237, DOI 10.1016/j.apmr.2011.08.042
   Chu HT, 2014, CARBON, V66, P154, DOI 10.1016/j.carbon.2013.08.053
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Collective B. S. M., 2012, P 6 INT C TANG EMB E, P367
   Ding QC, 2013, DISPLAYS, V34, P125, DOI 10.1016/j.displa.2012.08.004
   Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
   Friederich A, 2010, SCAND J OCCUP THER, V17, P308, DOI 10.3109/11038120903377082
   Hancock C., 2013, TEXTUAL CULTURES TEX, V8, P72100
   Hedges LV, 2013, RES SYNTH METHODS, V4, P324, DOI 10.1002/jrsm.1086
   Hedges LV, 2012, RES SYNTH METHODS, V3, P224, DOI 10.1002/jrsm.1052
   Hogg L, 2012, J PHYSIOTHER, V58, P189, DOI 10.1016/S1836-9553(12)70110-8
   Howden EJ, 2013, CLIN J AM SOC NEPHRO, V8, P1494, DOI 10.2215/CJN.10141012
   Huang PC, 2014, RES DEV DISABIL, V35, P393, DOI 10.1016/j.ridd.2013.11.017
   Kagohara DM, 2012, RES AUTISM SPECT DIS, V6, P304, DOI 10.1016/j.rasd.2011.05.012
   Kanter D. E., 2013, DESIGN MAKE PLAY GRO
   Lancioni GE, 2011, RES DEV DISABIL, V32, P576, DOI 10.1016/j.ridd.2010.12.017
   Lotan M, 2009, 2009 VIRTUAL REHABILITATION INTERNATIONAL CONFERENCE, P70, DOI 10.1109/ICVR.2009.5174208
   Mirandola D., 2013, J PHYS ACTIVITY HLTH
   Monroy-Hernandez Andres, 2008, Interactions, V15, DOI 10.1145/1340961.1340974
   Neely L, 2013, RES AUTISM SPECT DIS, V7, P509, DOI 10.1016/j.rasd.2012.12.004
   Resnick M., 2013, DESIGN MAKE PLAY GRO, P163
   Seeber M, 2011, J COMPUT CHEM, V32, P1183, DOI 10.1002/jcc.21688
   Shih CH, 2012, RES DEV DISABIL, V33, P1194, DOI 10.1016/j.ridd.2012.02.008
   Shih CH, 2013, RES DEV DISABIL, V34, P1521, DOI 10.1016/j.ridd.2013.01.018
   Shih CT, 2013, RES DEV DISABIL, V34, P4328, DOI 10.1016/j.ridd.2013.09.001
   Standen PJ, 2011, COMPUT EDUC, V56, P2, DOI 10.1016/j.compedu.2010.06.003
   Sun E., 2013, CHI13 EXTENDED ABSTR, P1275
   Wu FG, 2011, DISPLAYS, V32, P284, DOI 10.1016/j.displa.2011.05.007
NR 36
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP
PY 2014
VL 35
IS 9
BP 1963
EP 1969
DI 10.1016/j.ridd.2014.04.028
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK1MM
UT WOS:000338179200005
PM 24864049
ER

PT J
AU Visser, EM
   Berger, HJC
   Prins, JB
   Lantman-De Valk, HMJV
   Teunisse, JP
AF Visser, E. M.
   Berger, H. J. C.
   Prins, J. B.
   Lantman-De Valk, H. M. J. Van Schrojenstein
   Teunisse, J. P.
TI Shifting impairment and aggression in intellectual disability and Autism
   Spectrum Disorder
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Cognitive shifting; Aggression; Autism; Intellectual disability
ID BEHAVIOR RATING INVENTORY; CARD SORTING TEST; CHALLENGING BEHAVIOR;
   EXECUTIVE FUNCTION; PHYSICAL AGGRESSION; NEUROPSYCHOLOGICAL TESTS; TOTAL
   POPULATION; RISK MARKERS; YOUNG-ADULTS; CHILDREN
AB Aggressive behaviour is a major problem in individuals with an intellectual disability (ID)as well as in individuals with an Autism Spectrum Disorder (ASD). There are indications that suggest a link between cognitive shifting and aggression. In this study, reports of aggressive incidents of adolescents and young adults with different clinical diagnoses (ID, ID + ASD, ASD) were collected during 1 year, using the Staff Observation Aggression Scale-Revised. Whether they were diagnosed with ID, ASD or both; individuals who displayed aggression were found to face more cognitive shifting difficulties than non-aggressive individuals, while no significant differences were found on severity of ASD symptoms. Study results support the assumption that a cognition-based model for aggression may be more adequate than a diagnose-based model. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Visser, E. M.; Berger, H. J. C.; Prins, J. B.; Teunisse, J. P.] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, NL-6500 HB Nijmegen, Netherlands.
   [Lantman-De Valk, H. M. J. Van Schrojenstein] Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Hlth Care, NL-6500 HB Nijmegen, Netherlands.
   [Teunisse, J. P.] Dr Leo Kannerhuis, Ctr Autism, Dept Res & Dev, NL-6865 ZH Doorwerth, Netherlands.
   [Teunisse, J. P.] HAN Univ Appl Sci, Res Grp Autism Lifespan, NL-6503 GL Nijmegen, Netherlands.
RP Teunisse, JP (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM jp.teunisse@leokannerhuis.nl
RI Schrojenstein Lantman-de Valk, H.M.J./H-8087-2014
CR Abderhalden C., 2007, CLIN PRACTICE EPIDEM, V3
   Achenbach TM, 2003, MANUAL ASEBA ADULT F
   Allen D, 2000, J INTELLECT DEV DIS, V25, P41, DOI 10.1080/132697800112776
   Almvik R, 2006, INT J GERIATR PSYCH, V21, P368, DOI 10.1002/gps.1474
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Benson BA, 2008, CURR OPIN PSYCHIATR, V21, P454, DOI 10.1097/YCO.0b013e328306a090
   Berg EA, 1948, J GEN PSYCHOL, V39, P15
   Berger HJC, 2003, J CLIN EXP NEUROPSYC, V25, P502, DOI 10.1076/jcen.25.4.502.13870
   BERGER HJC, 1989, NEUROPSYCHOLOGIA, V27, P629, DOI 10.1016/0028-3932(89)90109-7
   BROMLEY J, 1995, J INTELL DISABIL RES, V39, P341
   Brosnan J, 2011, RES DEV DISABIL, V32, P437, DOI 10.1016/j.ridd.2010.12.023
   Cambridge Cognition, 1996, CANTAB
   CAMPBELL DT, 1959, PSYCHOL BULL, V56, P81, DOI 10.1037/h0046016
   Carney DPJ, 2013, RES DEV DISABIL, V34, P46, DOI 10.1016/j.ridd.2012.07.013
   Chaytor N, 2003, NEUROPSYCHOL REV, V13, P181, DOI 10.1023/B:NERV.0000009483.91468.fb
   Crocker AG, 2006, J INTELL DISABIL RES, V50, P652, DOI 10.1111/j.1365-2788.2006.00815.x
   DOWNES JJ, 1989, NEUROPSYCHOLOGIA, V27, P1329, DOI 10.1016/0028-3932(89)90128-0
   Emerson E, 2001, RES DEV DISABIL, V22, P77, DOI 10.1016/S0891-4222(00)00061-5
   Ernst R, 2000, FUNCTIONAL NEUROIMAG, P379, DOI 10.1017/CBO9780511470998.029
   Frazier PA, 2004, J COUNS PSYCHOL, V51, P115, DOI 10.1037/0022-0167.51.1.115
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P249, DOI 10.1076/chin.8.4.249.13513
   Gioia GA, 2000, CHILD NEUROPSYCHOL, V6, P235, DOI 10.1076/chin.6.3.235.3152
   Gligorovic M, 2013, J INTELLECT DEV DIS, V38, P134, DOI 10.3109/13668250.2013.772956
   Gomot M, 2012, INT J PSYCHOPHYSIOL, V83, P240, DOI 10.1016/j.ijpsycho.2011.09.017
   Gonzalez-Gadea ML, 2013, RES DEV DISABIL, V34, P817, DOI 10.1016/j.ridd.2012.11.009
   Grassi L, 2001, ACTA PSYCHIAT SCAND, V104, P273, DOI 10.1034/j.1600-0447.2001.00292.x
   Green V. A., 2008, NEW RES EARL CHILDH
   Hancock M, 2010, AGGRESSIVE BEHAV, V36, P338, DOI 10.1002/ab.20353
   Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
   Heaton R. K., 1993, WISC CARD SORT TEST
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Holden B, 2006, RES DEV DISABIL, V27, P456, DOI 10.1016/j.ridd.2005.06.001
   HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Ketelsen R, 2007, J PSYCHIATR MENT HLT, V14, P92
   Kiely J, 1998, DISABIL REHABIL, V20, P81
   Kraijer D, 2005, J AUTISM DEV DISORD, V35, P499, DOI 10.1007/s10803-005-5040-0
   Lerner MD, 2012, J AM ACAD PSYCHIATRY, V40, P177
   Luteijn F., 2004, GIT 2 GRONINGER INTE
   Mahone EM, 2002, ARCH CLIN NEUROPSYCH, V17, P643, DOI 10.1016/S0887-6177(01)00168-8
   Matson JL, 2008, J DEV PHYS DISABIL, V20, P41, DOI 10.1007/s10882-007-9078-0
   Mazurek MO, 2013, RES AUTISM SPECT DIS, V7, P455, DOI 10.1016/j.rasd.2012.11.004
   McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
   McTiernan A, 2011, RES AUTISM SPECT DIS, V5, P1215, DOI 10.1016/j.rasd.2011.01.009
   Miyake Akira, 2000, Seminars in Speech and Language, V21, P169, DOI 10.1055/s-2000-7563
   Morrison E F, 1990, Sch Inq Nurs Pract, V4, P65
   Nijman H. L. I., 2005, SOAS R AGGRESSIEREGI
   Nijman HLI, 2005, ACTA PSYCHIAT SCAND, V111, P12, DOI 10.1111/j.1600-0447.2004.00417.x
   Nijman HLI, 1999, AGGRESSIVE BEHAV, V25, P197, DOI 10.1002/(SICI)1098-2337(1999)25:3<197::AID-AB4>3.0.CO;2-C
   OZONOFF S, 1995, NEUROPSYCHOLOGY, V9, P491, DOI 10.1037//0894-4105.9.4.491
   Pellicano E., 2011, RES AUTISM SPECT DIS, P219, DOI 10.1017/CBO9780511973918.010
   Peters-Scheffer N, 2008, RES DEV DISABIL, V29, P398, DOI 10.1016/j.ridd.2007.07.004
   Pihet S, 2012, PSYCHIAT PSYCHOL LAW, V19, P427, DOI 10.1080/13218719.2011.598634
   Pituch KA, 2007, RES AUTISM SPECT DIS, V1, P55, DOI 10.1016/j.rasd.2006.07.005
   Quek LH, 2012, J CLIN PSYCHOL, V68, P1142, DOI 10.1002/jclp.21888
   Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
   Roelofs R. L., 2014, J INTELLECTUAL DISAB
   Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
   Sanders J, 2008, RES AUTISM SPECT DIS, V2, P1, DOI 10.1016/j.rasd.2007.03.005
   Smidts D., 2009, BRIEF EXECUTIVE FUNC
   Steinert T, 2000, ACTA PSYCHIAT SCAND, V102, P107, DOI 10.1034/j.1600-0447.2000.102002107.x
   Tenneij NH, 2009, ARCH PSYCHIAT NURS, V23, P283, DOI 10.1016/j.apnu.2008.07.001
   Tenneij NH, 2008, J INTELL DISABIL RES, V52, P114, DOI 10.1111/j.1365-2788.2007.00968.x
   Tenneij NH, 2007, J APPL RES INTELLECT, V20, P391, DOI 10.1111/j.1468-3148.2007.00383.x
   Tenneij NH, 2009, RES DEV DISABIL, V30, P1248, DOI 10.1016/j.ridd.2009.04.006
   Teunisse JP, 2012, J CLIN EXP NEUROPSYC, V34, P714, DOI 10.1080/13803395.2012.670209
   Teunisse JP, 2001, J AUTISM DEV DISORD, V31, P55, DOI 10.1023/A:1005613730126
   Tsiouris JA, 2011, J INTELL DISABIL RES, V55, P636, DOI 10.1111/j.1365-2788.2011.01418.x
   Tyrer F, 2006, J INTELL DISABIL RES, V50, P295, DOI 10.1111/j.1365-2788.2005.00774.x
   Van der Molen MJW, 2010, RES DEV DISABIL, V31, P426, DOI 10.1016/j.ridd.2009.10.013
   Visser E. M., 2014, COGNITIVE SHIF UNPUB
   Vriezen ER, 2002, CHILD NEUROPSYCHOL, V8, P296, DOI 10.1076/chin.8.4.296.13505
   White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
   Woittiez I., 2012, IQ MET BEPERKINGEN M
   Woodcock KA, 2011, J INTELL DISABIL RES, V55, P152, DOI 10.1111/j.1365-2788.2010.01368.x
   World Medical Association General Assembly, 2008, WMA DECL HELS ETH PR
   Yerys BE, 2009, AUTISM, V13, P523, DOI 10.1177/1362361309335716
NR 80
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP
PY 2014
VL 35
IS 9
BP 2137
EP 2147
DI 10.1016/j.ridd.2014.04.021
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK1MM
UT WOS:000338179200023
PM 24881008
ER

PT J
AU Lancioni, GE
   Singh, NN
   O'Reilly, MF
   Sigafoos, J
   Alberti, G
   Perilli, V
   Oliva, D
   Buono, S
AF Lancioni, Giulio E.
   Singh, Nirbhay N.
   O'Reilly, Mark F.
   Sigafoos, Jeff
   Alberti, Gloria
   Perilli, Viviana
   Oliva, Doretta
   Buono, Serafino
TI Microswitch-aided programs to support physical exercise or adequate
   ambulation in persons with multiple disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Microswitch-aided programs; Head movements; Arms movements; Ambulation;
   Toe walking; Multiple disabilities
ID PROFOUND INTELLECTUAL DISABILITIES; AUTISM SPECTRUM DISORDERS;
   IDIOPATHIC TOE WALKING; DEVELOPMENTAL-DISABILITIES; SELF-DETERMINATION;
   SOCIAL VALIDATION; ENVIRONMENTAL STIMULATION; ASSISTING PEOPLE;
   CHILDREN; ADULTS
AB Three microswitch-aided programs were assessed in three single-case studies to enhance physical exercise or ambulation in participants with multiple disabilities. Study I was aimed at helping a woman who tended to have the head bending forward and the arms down to exercise a combination of appropriate head and arms movements. Study II was aimed at promoting ambulation continuity with a man who tended to have ambulation breaks. Study III was aimed at promoting ambulation with appropriate foot position in a girl who usually showed toe walking. The experimental designs of the studies consisted of a multiple probe across responses (Study I), an ABAB sequence (Study II), and an ABABB(1) sequence (Study III). The last phase of each study was followed by a post-intervention check. The microswitches monitored the target responses selected for the participants and triggered a computer system to provide preferred stimuli contingent on those responses during the intervention phases of the studies. Data showed that the programs were effective with each of the participants who learned to exercise head and arms movements, increased ambulation continuity, and acquired high levels of appropriate foot position during ambulation, respectively. The positive performance levels were retained during the post-intervention checks. The discussion focused on (a) the potential of technology-aided programs for persons with multiple disabilities and (b) the need of replication studies to extend the evidence available in the area. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lancioni, Giulio E.] Univ Bari, I-70100 Bari, Italy.
   [Singh, Nirbhay N.] Georgia Regents Univ, Med Coll Georgia, Augusta, GA USA.
   [O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
   [Sigafoos, Jeff] Victoria Univ Wellington, Wellington, New Zealand.
   [Alberti, Gloria; Perilli, Viviana; Oliva, Doretta] Lega F DOro Res Ctr, Osimo, Italy.
   [Alberti, Gloria; Perilli, Viviana; Oliva, Doretta] Lega F DOro Res Ctr, Lesmo, Italy.
   [Buono, Serafino] IRCCS Oasi Troina, Troina Enna, Italy.
RP Lancioni, GE (reprint author), Univ Bari, Dept Neurosci & Sense Organs, Via Quintino Sella 268, I-70100 Bari, Italy.
EM giulio.lancioni@uniba.it
CR ACCARDO P, 1989, CLIN PEDIATR, V28, P347, DOI 10.1177/000992288902800802
   Barlow D., 2009, SINGLE CASE EXPT DES
   Barrow WJ, 2011, J CHILD NEUROL, V26, P619, DOI 10.1177/0883073810385344
   Belva BC, 2013, RES DEV DISABIL, V34, P596, DOI 10.1016/j.ridd.2012.09.021
   Bindels-de Heus KGCB, 2013, INTELLECT DEV DISAB, V51, P176, DOI 10.1352/1934-9556-51.3.176
   Borg J, 2011, DISABIL SOC, V26, P151, DOI 10.1080/09687599.2011.543862
   Borrero CSW, 2010, J EXP ANAL BEHAV, V93, P455, DOI 10.1901/jeab.2010.93-455
   Callahan K, 2008, J AUTISM DEV DISORD, V38, P678, DOI 10.1007/s10803-007-0434-9
   Carter EW, 2009, AJIDD-AM J INTELLECT, V114, P179, DOI 10.1352/1944-7558-114.3.179
   Catania A. C., 2012, LEARNING, V5th
   Chantry J, 2010, BRIT J OCCUP THER, V73, P351, DOI 10.4276/030802210X12813483277107
   Damiano DL, 2009, J NEUROL PHYS THER, V33, P27, DOI 10.1097/NPT.0b013e31819800e2
   Davies G, 2013, EDUC TRAIN AUTISM DE, V48, P269
   Dillon CM, 2007, BEHAV INTERVENT, V22, P229, DOI 10.1002/bin.240
   Dunst C. J., 2007, BEHAV ANAL TODAY, V8, P226
   Eiff MP, 2006, J FAM PRACTICE, V55, P447
   Foley A, 2012, J RES SPECIAL ED NEE, V12, P192, DOI DOI 10.1111/J.1471-3802.2011.01230.X
   Fox Anna, 2006, Acta Orthop Belg, V72, P722
   Giagazoglou P, 2013, RES DEV DISABIL, V34, P2701, DOI 10.1016/j.ridd.2013.05.034
   Helton JJ, 2011, CHILD ABUSE NEGLECT, V35, P956, DOI 10.1016/j.chiabu.2011.06.004
   Holburn S, 2004, BEHAV INTERVENT, V19, P25, DOI 10.1002/bin.147
   KAZDIN AE, 2001, BEHAV MODIFICATION A
   Kennedy C, 2005, SINGLE CASE DESIGNS
   Ketelaar M, 2001, PHYS THER, V81, P1534
   Lancioni G. E., 2014, J INTELLECT IN PRESS
   Lancioni GE, 2014, RES DEV DISABIL, V35, P1264, DOI 10.1016/j.ridd.2014.03.026
   Lancioni G. E., 2013, DEV NEUROREHABIL, V16, P230
   Lancioni GE, 2014, AUT CHILD PSYCHO, P1, DOI 10.1007/978-1-4899-8029-8
   Lancioni Giulio E, 2013, Disabil Rehabil Assist Technol, V8, P92, DOI 10.3109/17483107.2012.678030
   Lancioni GE, 2012, J DEV PHYS DISABIL, V24, P415, DOI 10.1007/s10882-012-9279-z
   Lancioni GE, 2012, J INTELLECT DEV DIS, V37, P337, DOI 10.3109/13668250.2012.726351
   Lancioni GE, 2010, RES DEV DISABIL, V31, P811, DOI 10.1016/j.ridd.2010.02.006
   Lancioni GE, 2012, RES DEV DISABIL, V33, P111, DOI 10.1016/j.ridd.2011.08.029
   Lancioni GE, 2014, FRONT HUM NEUROSCI, V8, DOI 10.3389/fnhum.2014.00025
   Lancioni GE, 2009, RES DEV DISABIL, V30, P308, DOI 10.1016/j.ridd.2008.05.002
   Lancioni GE, 2007, J DEV PHYS DISABIL, V19, P1, DOI 10.1007/s10882-006-9030-8
   Leung Brian, 2010, Disabil Rehabil Assist Technol, V5, P58, DOI 10.3109/17483100903254561
   Leung B, 2014, J NEUROENG REHABIL, V11, DOI 10.1186/1743-0003-11-34
   Lucas JW, 2012, SOC PSYCHOL QUART, V75, P310, DOI 10.1177/0190272512459968
   Luiselli JK, 2010, BEHAV MODIF, V34, P403, DOI 10.1177/0145445510383526
   Lundequam Pamela, 2009, Cases J, V2, P188, DOI 10.1186/1757-1626-2-188
   Mechling LC, 2006, J SPEC EDUC, V40, P94, DOI 10.1177/00224669060400020501
   Miramontes N. Y., 2011, EDUC TREAT CHILD, V34, P445
   Mitelman R, 2009, J NEUROSCI METH, V178, P350, DOI 10.1016/j.jneumeth.2008.12.007
   Nicolson Amy, 2012, Disabil Rehabil Assist Technol, V7, P345, DOI 10.3109/17483107.2012.667194
   Oetgen ME, 2012, J AM ACAD ORTHOP SUR, V20, P292, DOI 10.5435/JAAOS-20-05-292
   Page J, 2013, J APPL SPORT PSYCHOL, V25, P61, DOI 10.1080/10413200.2012.663859
   Palisano RJ, 2012, DISABIL REHABIL, V34, P1041, DOI 10.3109/09638288.2011.628740
   Pergami P, 2012, NEUROINFORMATICS, V10, P323, DOI 10.1007/s12021-011-9139-5
   Pierce W. D., 2008, BEHAV ANAL LEARNING
   Poon KK, 2013, RES AUTISM SPECT DIS, V7, P382, DOI 10.1016/j.rasd.2012.10.006
   Ripat Jacquie, 2011, Disabil Rehabil Assist Technol, V6, P87, DOI 10.3109/17483107.2010.507859
   Scherer M. J., 2012, ASSISTIVE TECHNOLOGI
   Segizbaeva M. O., 2011, Human Physiology, V37, P171, DOI 10.1134/S0362119711020198
   Shih CH, 2012, RES DEV DISABIL, V33, P621, DOI 10.1016/j.ridd.2011.10.024
   Shih CH, 2011, RES DEV DISABIL, V32, P2005, DOI 10.1016/j.ridd.2011.04.008
   Shih CT, 2013, RES DEV DISABIL, V34, P4328, DOI 10.1016/j.ridd.2013.09.001
   Shin IS, 2012, RES DEV DISABIL, V33, P1937, DOI 10.1016/j.ridd.2012.05.019
   Shogren KA, 2011, INTELLECT DEV DISAB, V49, P86, DOI 10.1352/1934-9556-49.2.86
   Shulman LH, 1997, J PEDIATR-US, V130, P541, DOI 10.1016/S0022-3476(97)70236-1
   Stewart S, 2009, BRIT J LEARN DISABIL, V37, P232, DOI 10.1111/j.1468-3156.2009.00554.x
   Tam GM, 2011, RES DEV DISABIL, V32, P2352, DOI 10.1016/j.ridd.2011.07.027
   Van Rensburg J., 2007, J CHILD ADOLESCENT M, V19, P115
   Verdugo MA, 2012, J INTELL DISABIL RES, V56, P1036, DOI 10.1111/j.1365-2788.2012.01585.x
   Wehmeyer ML, 2013, J SPEC EDUC, V46, P195, DOI 10.1177/0022466910392377
   West EA, 2013, EDUC TRAIN AUTISM DE, V48, P443
NR 66
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP
PY 2014
VL 35
IS 9
BP 2190
EP 2198
DI 10.1016/j.ridd.2014.05.015
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK1MM
UT WOS:000338179200028
PM 24915648
ER

PT J
AU Cantwell, J
   Muldoon, OT
   Gallagher, S
AF Cantwell, Joanne
   Muldoon, Orla T.
   Gallagher, Stephen
TI Social support and mastery influence the association between stress and
   poor physical health in parents caring for children with developmental
   disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Parents; Developmental disability; Physical health; Mastery; Social
   support; Stress
ID AUTISM SPECTRUM DISORDER; BEHAVIOR PROBLEMS; INTELLECTUAL DISABILITIES;
   YOUNG-ADULTS; DIFFICULTIES QUESTIONNAIRE; SYNDROME SPECIFICITY;
   EXPRESSED EMOTION; ANTIBODY-RESPONSE; PERCEIVED STRESS; RECEIVED SUPPORT
AB To date, much of the research linking the stress of caring for children with developmental disabilities (e.g. Autism & Down syndrome) with parental health outcomes have tended to concentrate on mental health with less attention paid to the physical health consequences. Thus, this study sought to explore the psychosocial predictors of poor physical health in these caring parents. One hundred and sixty-seven parents (109 caregivers and 58 control parents) completed measures of stress, child problem behaviours, social support, mastery and physical health. Parents of children with developmental disabilities had poorer physical health compared to control parents. Stress and mastery, but not social support and problem behaviours, were significant predictors of poor physical health within caring parents for children with developmental disabilities. However, the association between mastery and physical health was mediated by perceived stress such that those parents who were higher on mastery reported less stress and better physical health; furthermore, the association between stress and physical health was moderated by social support; those parents high on social support and low in stress had better physical health. These results indicate that the paths between psychosocial factors and poor physical health in the caring parents are working synergistically rather than in isolation. They also underscore the importance of providing multi-component interventions that offer a variety of psychosocial resources to meet the precise needs of the parents. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Cantwell, Joanne; Muldoon, Orla T.; Gallagher, Stephen] Univ Limerick, Dept Psychol, Limerick, Ireland.
   [Cantwell, Joanne; Muldoon, Orla T.; Gallagher, Stephen] Univ Limerick, Ctr Social Issues Res, Limerick, Ireland.
RP Cantwell, J (reprint author), Univ Limerick, Dept Psychol, Limerick, Ireland.
EM Joanne.Cantwell@ul.ie
CR Bailey D., 1994, J SOCIOLOGY SOCIAL W, V21, P127
   Baker JK, 2012, J INTELL DISABIL RES, V56, P984, DOI 10.1111/j.1365-2788.2012.01580.x
   Beck A, 2004, J INTELL DISABIL RES, V48, P628, DOI 10.1111/j.1365-2788.2003.00564.x
   Benyamini Y, 2011, PSYCHOL HEALTH, V26, P1446, DOI 10.1080/08870446.2011.559231
   Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
   Blom MM, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-17
   Bovier PA, 2004, QUAL LIFE RES, V13, P161, DOI 10.1023/B:QURE.0000015288.43768.e4
   COHEN S, 1985, PSYCHOL BULL, V98, P310, DOI 10.1037//0033-2909.98.2.310
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Deutskens E, 2006, J SERV RES-US, V8, P346, DOI 10.1177/1094670506286323
   Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
   Dunst C., 1984, J INDIVIDUAL FAMILY, V1, P45
   Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
   Floyd FJ, 1997, FAM RELAT, V46, P359, DOI 10.2307/585096
   Gallagher S, 2012, RES DEV DISABIL, V33, P2099, DOI 10.1016/j.ridd.2012.06.007
   Gallagher S, 2010, J PEDIATR PSYCHOL, V35, P728, DOI 10.1093/jpepsy/jsp093
   Gallagher S, 2014, RES DEV DISABIL, V35, P448, DOI 10.1016/j.ridd.2013.11.029
   Gallagher S, 2013, J HEALTH PSYCHOL, V18, P1220, DOI 10.1177/1359105312464672
   Gallagher S, 2009, BRAIN BEHAV IMMUN, V23, P338, DOI 10.1016/j.bbi.2008.05.006
   Gallagher S., 2014, J RELIG HLT IN PRESS
   Geerlings SW, 2000, PSYCHOL MED, V30, P369, DOI 10.1017/S0033291799001890
   Goodman R, 1999, J ABNORM CHILD PSYCH, V27, P17, DOI 10.1023/A:1022658222914
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Gray DE, 2006, J INTELL DISABIL RES, V50, P970, DOI 10.1111/j.1365-2788.2006.00933.x
   Hastings RP, 2006, AM J MENT RETARD, V111, P48, DOI 10.1352/0895-8017(2006)111[48:MDAEEC]2.0.CO;2
   Hayes A. F., 2012, PROCESS VERSATILE CO
   Hemmingsson H, 2009, CHILD CARE HLTH DEV, V35, P89, DOI 10.1111/j.1365-2214.2008.00907.x
   Hodapp RM, 1998, J INTELL DISABIL RES, V42, P331, DOI 10.1046/j.1365-2788.1998.00148.x
   Idler E., 1999, J HEALTH SOC BEHAV, V38, P21
   Ingersoll BR, 2013, AUTISM, V17, P434, DOI 10.1177/1362361311427155
   Karazsia B. T., 2013, J PEDIATR PSYCHOL, V39, P163
   Lazarus RS, 1984, STRESS
   Lovell B, 2012, RES DEV DISABIL, V33, P682, DOI 10.1016/j.ridd.2011.11.014
   Lundgren O., 2014, INT J BEHAV MED, P1
   Matthews K. A., 2012, ANNU REV PSYCHOL, V62, P501
   McCurry S., 2009, SLEEP MED CLIN, V4, P519
   Mfirelius E., 2013, CHILD CARE HLTH DEV, V40, P412
   Miodrag N, 2010, CURR OPIN PSYCHIATR, V23, P407, DOI 10.1097/YCO.0b013e32833a8796
   Nankervis K, 2011, J INTELL DISABIL RES, V55, P422, DOI 10.1111/j.1365-2788.2011.01389.x
   Office of Population Censuses and Surveys, 1978, OCC MORT 1970 72
   Olsson MB, 2008, J INTELL DISABIL RES, V52, P1102, DOI 10.1111/j.1365-2788.2008.01081.x
   Paczkowski E, 2007, J INTELL DISABIL RES, V51, P435, DOI 10.1111/j.1365-2788.2006.00894.x
   PEARLIN LI, 1978, J HEALTH SOC BEHAV, V19, P2, DOI 10.2307/2136319
   Raina P., 2005, PEDIATRICS, V115, P626, DOI DOI 10.1542/PEDS.2004-1689
   Reinhardt JP, 2006, J SOC PERS RELAT, V23, P117, DOI 10.1177/0265407506060182
   Resch JA, 2012, REHABIL PSYCHOL, V57, P61, DOI 10.1037/a0027155
   Rodin J., 1999, REV GEN PSYCHOL, V3, P317, DOI 10.1037/1089-2680.3.4.317
   Roepke SK, 2008, AM J GERIAT PSYCHIAT, V16, P310, DOI 10.1097/JGP.0b013e3181662a80
   Ruiz-Robledillo N, 2014, RES DEV DISABIL, V35, P686, DOI 10.1016/j.ridd.2013.12.007
   Schat ACH, 2005, J OCCUP HEALTH PSYCH, V10, P363, DOI 10.1037/1076-8998.10.4.363
   Scorgie K., 1998, DEV DISABILITIES B, V26, P23
   SEEMAN M, 1995, SOC SCI MED, V41, P517, DOI 10.1016/0277-9536(94)00362-W
   Seidman G, 2006, PERS SOC PSYCHOL B, V32, P52, DOI 10.1177/0146167205279582
   Seltzer M. M., 2001, J INFORM, V106
   Shattuck PT, 2011, ARCH PEDIAT ADOL MED, V165, P141, DOI 10.1001/archpediatrics.2010.279
   Sherwood A, 2007, ARCH INTERN MED, V167, P367, DOI 10.1001/archinte.167.4.367
   SINGER L, 1989, FAM RELAT, V38, P444, DOI 10.2307/585751
   Sipal RF, 2010, CHILD CARE HLTH DEV, V36, P74, DOI 10.1111/j.1365-2214.2009.01004.x
   Solomon M, 2008, J AUTISM DEV DISORD, V38, P1767, DOI 10.1007/s10803-008-0567-5
   Thurston S, 2011, J INTELL DISABIL RES, V55, P263, DOI 10.1111/j.1365-2788.2010.01356.x
   Trute B, 2010, J INTELLECT DEV DIS, V35, P36, DOI 10.3109/13668250903496328
   Uchino BN, 2009, PERSPECT PSYCHOL SCI, V4, P236, DOI 10.1111/j.1745-6924.2009.01122.x
   van den Borne HW, 1999, PATIENT EDUC COUNS, V38, P205, DOI 10.1016/S0738-3991(99)00004-X
   Vedhara K, 1999, LANCET, V353, P627, DOI 10.1016/S0140-6736(98)06098-X
NR 64
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP
PY 2014
VL 35
IS 9
BP 2215
EP 2223
DI 10.1016/j.ridd.2014.05.012
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK1MM
UT WOS:000338179200031
PM 24927515
ER

PT J
AU Kim, MS
   Blair, KSC
   Lim, KW
AF Kim, Mi-seon
   Blair, Kwang-Sun Cho
   Lim, Kyoung-won
TI Using tablet assisted Social Stories (TM) to improve classroom behavior
   for adolescents with intellectual disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Tablet; Multimedia; Social Stories (TM); Intellectual disabilities;
   Problem behavior; Academic engagement
ID AUTISM SPECTRUM DISORDERS; SPEECH-GENERATING DEVICE; 2 STUDENTS;
   CHILDREN; SKILLS; IPOD; IPAD; INDIVIDUALS; INSTRUCTION; ENGAGEMENT
AB The present study examined the use of tablet assisted Social Stories (TM) intervention for three high school students with severe intellectual disabilities whose problem behavior interfered with their learning and caused classroom disruptions. A multiple probe design across participants was employed to test the impact of the tablet assisted SS on the participants' target behaviors. During intervention, the participants read the Social Stories that were created on Prezi and accessed via Quick Response (QR) codes using a Galaxy Tap smart tablet before participating in an academic period. Data indicated that the SS intervention decreased disruptive behavior and increased academic engagement in all three participants. All three demonstrated generalization of behaviors to a nontargeted academic period and maintenance of improved behaviors at the 2-week follow-up. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Kim, Mi-seon; Lim, Kyoung-won] Kongju Natl Univ, Gongju, South Korea.
   [Blair, Kwang-Sun Cho] Univ S Florida, Tampa, FL 33612 USA.
RP Blair, KSC (reprint author), Univ S Florida, 13301 Bruce B Downs Blvd,MHC 2336, Tampa, FL 33612 USA.
EM kwangsun@usf.edu
CR Achmadi D, 2012, RES AUTISM SPECT DIS, V6, P1258, DOI 10.1016/j.rasd.2012.05.005
   Allen David, 2008, J Intellect Disabil, V12, P267, DOI 10.1177/1744629508100494
   Barry L. M., 2004, FOCUS AUTISM OTHER D, V19, P45, DOI DOI 10.1177/10883576040190010601
   Bender C., 2012, P SOC INF TECHN TEAC, P2708
   BIJOU SW, 1968, J APPL BEHAV ANAL, V1, P175, DOI 10.1901/jaba.1968.1-175
   Borrero CSW, 2006, J APPL BEHAV ANAL, V39, P375, DOI 10.1901/jaba.2006.170-04
   Bowker A., 2009, PERSPECTIVES AUGMENT, V18, P137, DOI DOI 10.1044/AAC18.4.137
   Browder DM, 2012, EDUC TRAIN AUTISM DE, V47, P373
   Brownell MD, 2002, J MUSIC THER, V39, P117
   Burton CE, 2013, FOCUS AUTISM DEV DIS, V28, P67, DOI 10.1177/1088357613478829
   Carr E. G., 1999, POSITIVE BEHAV SUPPO
   CARR EG, 1980, J APPL BEHAV ANAL, V13, P101, DOI 10.1901/jaba.1980.13-101
   Carter EW, 2010, RES PRACT PERS SEV D, V35, P63
   Chestock MA, 2008, INTELLECT DEV DISAB, V46, P376, DOI 10.1352/2008.46:376-386
   Chowdhury M, 2011, RES DEV DISABIL, V32, P383, DOI 10.1016/j.ridd.2010.11.015
   Cihak D, 2010, J POSIT BEHAV INTERV, V12, P103, DOI 10.1177/1098300709332346
   Crozier S., 2005, FOCUS AUTISM OTHER D, V20, P150, DOI DOI 10.1177/10883576050200030301
   Crozier S, 2007, J AUTISM DEV DISORD, V37, P1803, DOI 10.1007/s10803-006-0315-7
   Cumming Therese M., 2013, Journal of Special Education Technology, V28
   Delano M, 2006, J POSIT BEHAV INTERV, V8, P29, DOI 10.1177/10983007060080010501
   Dettmer S., 2000, FOCUS AUTISM OTHER D, V15, P163, DOI DOI 10.1177/108835760001500307
   Durand V. M., 2001, FOCUS AUTISM DEV DIS, V15, P110, DOI 10.1177/108835760101600207
   Duttlinger C, 2013, FOCUS AUTISM DEV DIS, V28, P32, DOI 10.1177/1088357612460572
   Flores M, 2012, AUGMENT ALTERN COMM, V28, P74, DOI 10.3109/07434618.2011.644579
   FOSTERJOHNSON L, 1994, J APPL BEHAV ANAL, V27, P493, DOI 10.1901/jaba.1994.27-493
   Gardner W. I., 2007, HDB INTELLECTUAL DEV, P541, DOI 10.1007/0-387-32931-5_27
   Gardner W. I., 2005, BEHAV MODIFICATION P, P279
   Gast D. L., 2009, SINGLE SUBJECT RES B
   Gray C. A, 2004, JENISON AUTISM J, V15, P2
   Gray C.A., 1998, ASPERGER SYNDROME HI, P167
   Hammond DL, 2010, EDUC TRAIN AUTISM DE, V45, P525
   Han S. K., 2012, COMMUNICATION SCI DI, V17, P92
   Han S. R., 2010, THESIS GYEONGIN NATL
   IRVINE AB, 1992, EDUC TRAIN MENT RET, V27, P241
   Ivey M. L., 2004, FOCUS AUTISM OTHER D, V19, P164, DOI DOI 10.1177/10883576040190030401
   Jeong D. Y., 2010, KOREAN J EMOTIONAL B, V26, P281
   Jeong D. Y., 2011, KOREAN J EMOTIONAL B, V27, P235
   Jeong I. S., 2003, KOREAN I SPECIAL ED
   Jeong L. Y., 2011, THESIS KONGJU NATL U
   Joe H. H., 2012, REHABILITATION RES, V16, P193
   Joe Y.M., 2010, THESIS INJE U S KORE
   Jowett EL, 2012, DEV NEUROREHABIL, V15, P304, DOI 10.3109/17518423.2012.682168
   Kagohara D. M., 2010, CLIN CASE STUDIES, V9, P328, DOI DOI 10.1177/1534650110379633
   Kagohara DM, 2013, RES DEV DISABIL, V34, P147, DOI 10.1016/j.ridd.2012.07.027
   Kim J. I., 2005, J EMOT BEHAV DISORD, V21, P231
   Kim Kyung-min, 2012, [Special Education Research, 특수교육], V11, P27
   Knight VF, 2013, FOCUS AUTISM DEV DIS, V28, P115, DOI 10.1177/1088357612475301
   Kokina A, 2010, J AUTISM DEV DISORD, V40, P812, DOI 10.1007/s10803-009-0931-0
   Kuoch H., 2003, FOCUS AUTISM OTHER D, V18, P219, DOI DOI 10.1177/10883576030180040301
   Kwon J. M., 2011, J INTELL DISABIL RES, V13, P187
   Lai H., 2013, BRIT J EDUC TECHNOL, V44, P57
   Lee Sang-kyu, 2007, Korean Journal of Systematic Zoology, V23, P103
   Lee Sungsu, 2011, [Journal of the Architectural Institute of Korea Structure & Construction, 대한건축학회논문집 구조계], V27, P77
   Lim J. H., 2011, KOREAN J SPECIAL ED, V46, P85
   Lindsay WR, 2002, J APPL RES INTELLECT, V15, P111, DOI 10.1046/j.1468-3148.2002.00112.x
   Mancil GR, 2009, FOCUS AUTISM DEV DIS, V24, P205, DOI 10.1177/1088357609347324
   Mayer-Johnson R., 1994, PICTURE COMMUNICATIO
   McLean LK, 1996, AM J MENT RETARD, V100, P580
   Myles B. S., 1999, FOCUS AUTISM OTHER D, V14, P82, DOI 10.1177/108835769901400203
   Neely L, 2013, RES AUTISM SPECT DIS, V7, P509, DOI 10.1016/j.rasd.2012.12.004
   Norman J. M., 2001, Journal of Special Education Technology, V16
   Oeseburg B, 2010, RES DEV DISABIL, V31, P698, DOI 10.1016/j.ridd.2010.01.011
   Ozdemir S, 2008, J AUTISM DEV DISORD, V38, P1689, DOI 10.1007/s10803-008-0551-0
   Park K., 2002, KOREA I SPECIAL ED K
   Peck J., 1997, FOCUS AUTISM OTHER D, V12, P219, DOI DOI 10.1177/108835769701200404
   Reynhout G., 2008, AUSTRAL J SPECIAL ED, V32, P161, DOI DOI 10.1080/10300110802047210
   Reynhout G, 2006, J AUTISM DEV DISORD, V36, P445, DOI 10.1007/s10803-006-0086-1
   Richter S, 2011, EDUC TRAIN AUTISM DE, V46, P410
   Rodriguez C. D., 2013, INTERV SCH CLIN, V49, P244
   Sansosti FJ, 2008, J POSIT BEHAV INTERV, V10, P162, DOI 10.1177/1098300708316259
   Schneider N, 2010, J POSIT BEHAV INTERV, V12, P149, DOI 10.1177/1098300709334198
   Schroeder S. R., 2002, SELF INJURIOUS BEHAV, P41, DOI 10.1037/10457-003
   Smith M. B., 2005, MENTAL RETARDATION
   Walker H. M., 1991, SYSTEMATIC SCREENING
   Zaranis N., 2013, CREATIVE ED, V4, P1
NR 75
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP
PY 2014
VL 35
IS 9
BP 2241
EP 2251
DI 10.1016/j.ridd.2014.05.011
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK1MM
UT WOS:000338179200034
PM 24927518
ER

PT J
AU Konst, MJ
   Matson, JL
   Goldin, R
   Rieske, R
AF Konst, Matthew J.
   Matson, Johnny L.
   Goldin, Rachel
   Rieske, Robert
TI How does ASD symptomology correlate with ADHD presentations?
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorders; Tantrum behavior; Autism Spectrum Disorders -
   Comorbidity for Children (ASD-CC); Comorbidity
ID AUTISM SPECTRUM DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   PERVASIVE DEVELOPMENTAL DISORDER; DEFICIT HYPERACTIVITY DISORDER;
   DSM-IV-TR; SEVERE RETARDATION MESSIER; SOCIAL-SKILLS;
   DIAGNOSTIC-CRITERIA; PSYCHIATRIC-DISORDERS; MENTAL-RETARDATION
AB Elevated rates of attention deficit/hyperactivity disorder (ADHD) symptoms have been documented in the autism spectrum disorder (ASD) population. However, the recent restructuring of the ASD diagnostic category and its respective symptom structure has elicited concern about how these changes may impact prevalence rates, the deliverance of services, and the rates of comorbid psychopathology. At present, few researchers have investigated the prevalence rates of specific ADHD presentations within ASD populations. As we seek to increase our understanding of ADHD symptom manifestation in ASD populations it is important to establish base rates of attention and hyperactive symptoms. The current manuscript sought to investigate the prevalence of inattention and impulsive symptoms in 1722 infants and toddlers. Individuals were separated into three diagnostic groups for analyses, a DSM-5 ASD group, an atypically developing group, and a DSM-IV-TR ASD group. Initial analysis extended previous research by demonstrating significantly elevated rates of inattention/impulsive symptoms in toddlers meeting DSM-5 criteria for ASD when compared to the DSM-IV-TR ASD and atypically developing groups. Additional analysis demonstrated that ASD symptom severity was positively correlated with inattention/impulsive symptoms regardless of primary diagnosis. Lastly, analyses examined the exhibition of inattention and impulsive symptoms separately within diagnostic groups. Results suggest that the expression of impulsive and inattentive symptoms did not significantly differ within diagnostic groups. Published by Elsevier Ltd.
C1 [Konst, Matthew J.; Matson, Johnny L.; Goldin, Rachel; Rieske, Robert] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Konst, MJ (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM mkonst1@tigers.lsu.edu
CR Advokat CD, 2000, RES DEV DISABIL, V21, P75, DOI 10.1016/S0891-4222(99)00031-1
   Banaschewski T, 2011, NERVENARZT, V82, P573, DOI 10.1007/s00115-010-3239-6
   Beighley JS, 2013, DEV NEUROREHABIL, V16, P375, DOI 10.3109/17518423.2012.760119
   Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x
   Cappadocia MC, 2011, RES AUTISM SPECT DIS, V5, P70, DOI 10.1016/j.rasd.2010.04.001
   Field A., 2009, DISCOVERING STAT USI
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
   Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
   Gadow KD, 2004, J CHILD PSYCHOL PSYC, V45, P1135, DOI 10.1111/j.1469-7610.2004.00306.x
   de Alba MJG, 2011, RES AUTISM SPECT DIS, V5, P633, DOI 10.1016/j.rasd.2010.07.009
   Goldin RL, 2013, RES DEV DISABIL, V34, P2669, DOI 10.1016/j.ridd.2013.04.022
   Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
   Horovitz M, 2010, DEV NEUROREHABIL, V13, P390, DOI 10.3109/17518423.2010.501431
   Jang JN, 2013, RES DEV DISABIL, V34, P2369, DOI 10.1016/j.ridd.2013.04.021
   Jensen VK, 1997, CLIN PEDIATR, V36, P555, DOI 10.1177/000992289703601001
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Ledford J. R., 2006, FOCUS AUTISM OTHER D, V21, P153, DOI DOI 10.1177/10883576060210030401
   Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   LoVullo SV, 2012, RES AUTISM SPECT DIS, V6, P378, DOI 10.1016/j.rasd.2011.06.011
   Matson J. L., 2007, BABY INFANT SCREEN C
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P288, DOI 10.1016/j.rasd.2007.07.003
   Matson JL, 2013, RES DEV DISABIL, V34, P2475, DOI 10.1016/j.ridd.2013.05.021
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P633, DOI 10.1016/j.rasd.2009.12.007
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P237, DOI 10.1016/j.rasd.2007.06.003
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P252, DOI 10.1016/j.rasd.2008.06.005
   Matson JL, 2009, RES DEV DISABIL, V30, P1317, DOI 10.1016/j.ridd.2009.05.008
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   Matson JL, 1998, RES DEV DISABIL, V19, P493, DOI 10.1016/S0891-4222(98)00020-1
   Matson JL, 2012, J AUTISM DEV DISORD, V42, P1549, DOI 10.1007/s10803-012-1582-0
   Matson JL, 2008, J DEV PHYS DISABIL, V20, P155, DOI 10.1007/s10882-007-9086-0
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Matson JL, 2007, J INTELLECT DEV DIS, V32, P39, DOI 10.1080/13668250601184689
   Matson JL, 2010, RES DEV DISABIL, V31, P464, DOI 10.1016/j.ridd.2009.10.014
   Matson JL, 2009, RES DEV DISABIL, V30, P249, DOI 10.1016/j.ridd.2008.04.002
   Matson JL, 2010, DEV NEUROREHABIL, V13, P72, DOI 10.3109/17518420903213576
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P426, DOI 10.1016/j.rasd.2010.06.005
   Matson JL, 1999, BEHAV MODIF, V23, P647, DOI 10.1177/0145445599234008
   Matson JL, 2008, LANCET, V371, P9, DOI 10.1016/S0140-6736(08)60046-X
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P455, DOI 10.1016/j.rasd.2008.09.005
   Matson JL, 2012, DEV NEUROREHABIL, V15, P185, DOI 10.3109/17518423.2012.672341
   Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
   Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P277, DOI 10.1016/j.rasd.2011.05.009
   McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
   Newborg J, 2005, BATTELLE DEV INVENTO
   Reiersen Angela M, 2008, Expert Rev Neurother, V8, P657, DOI 10.1586/14737175.8.4.657
   Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
   Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
   Rivet TT, 2011, J DEV PHYS DISABIL, V23, P399, DOI 10.1007/s10882-011-9235-3
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Rowlandson PH, 2009, CHILD CARE HLTH DEV, V35, P681, DOI 10.1111/j.1365-2214.2009.00956.x
   Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Singh AN, 2005, RES DEV DISABIL, V26, P203, DOI 10.1016/j.ridd.2004.07.001
   Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
   Smalley SL, 2002, AM J HUM GENET, V71, P959, DOI 10.1086/342732
   Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1
   Tureck K, 2013, DEV NEUROREHABIL, V16, P52, DOI 10.3109/17518423.2012.719245
   Weinkauf SM, 2011, RES AUTISM SPECT DIS, V5, P864, DOI 10.1016/j.rasd.2010.10.001
   Wilkins J, 2009, BEHAV MODIF, V33, P143, DOI 10.1177/0145445508321880
   Williams LW, 2014, RES AUTISM SPECT DIS, V8, P186, DOI 10.1016/j.rasd.2013.11.007
   Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
   Worley JA, 2012, RES AUTISM SPECT DIS, V6, P965, DOI 10.1016/j.rasd.2011.12.012
   Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1
NR 65
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP
PY 2014
VL 35
IS 9
BP 2252
EP 2259
DI 10.1016/j.ridd.2014.05.017
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AK1MM
UT WOS:000338179200035
PM 24929307
ER

PT J
AU El-Ansary, A
   Al-Ayadhi, L
AF El-Ansary, Afaf
   Al-Ayadhi, Laila
TI Relative abundance of short chain and polyunsaturated fatty acids in
   propionic acid-induced autistic features in rat pups as potential
   markers in autism
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Propionic acid; Rodent model; Autism; Short chain fatty acids;
   Polyunsaturated fatty acids; Relative values
ID NF-KAPPA-B; DOCOSAHEXAENOIC ACID; ARACHIDONIC-ACID; SPECTRUM DISORDERS;
   OXIDATIVE STRESS; SODIUM-BUTYRATE; NA+ CHANNELS; GLIOMA-CELLS; BRAIN;
   METABOLISM
AB Background: Fatty acids are essential dietary nutrients, and one of their important roles is providing polyunsaturated fatty acids (PUFAs) for the growth and function of nervous tissue. Short chain fatty acids (SCFAs) are a group of compounds derived from the host microbiome that were recently linked to effects on the gut, the brain, and behavior. They are therefore linked to neurodevelopmental disorders such as autism. Reduced levels of PUFAs are associated with impairments in cognitive and behavioral performance, which are particularly important during brain development. Recent studies suggest that omega -3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are involved in neurogenesis, neurotransmission, and protection from oxidative stress. Omega-3 PUFAs mediate some of these effects by antagonizing Omega-6 PUFA (arachidonic acid, AA)-induced proinflammatory prostaglandin E-2 (PGE(2)) formation.
   Methods: In this work, the absolute and relative concentrations of propionic (PPA), butyric and acetic acids, as well as PUFAs and their precursors (alpha-Linolenic and linoleic), were measured in the brain tissue of PPA-neurointoxicated rat pups (receiving 250 mg PPA/Kg body weight for 3 consecutive days) as a rodent model with persistent autistic features compared with healthy controls.
   Results: The data revealed remarkably lower levels of omega6/omega3, alpha-Linolenic/Linoleic, alpha-Linolenic/EPA, alpha-Linolenic/DHA, EPA/DHA, and AA/Linoleic acid ratios in PPA-intoxicated rats. The role of these impaired ratios is discussed in relation to the activity of desaturases and elongases, which are the two enzymatic groups involved in the synthesis of PUFAs from their precursors. The relationship between the abnormal relative concentrations of the studied fatty acids and oxidative stress, neurotransmission, and neuroinflammation is also discussed in detail.
   Conclusions: This study demonstrates that fatty acid ratios are useful for understanding the mechanism of PPA neurotoxicity in a rodent model of autism. Therefore, it is possible to use these ratios for predictions in patients with this disorder.
C1 [El-Ansary, Afaf] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11495, Saudi Arabia.
   [El-Ansary, Afaf; Al-Ayadhi, Laila] Autism Res & Treatment Ctr, Riyadh, Saudi Arabia.
   [El-Ansary, Afaf; Al-Ayadhi, Laila] King Saud Univ, Shaik AL Amodi Autism Res Chair, Riyadh 11495, Saudi Arabia.
   [Al-Ayadhi, Laila] King Saud Univ, Fac Med, Dept Physiol, Riyadh 11495, Saudi Arabia.
   [El-Ansary, Afaf] Natl Res Ctr, Dept Med Chem, Cairo, Egypt.
RP El-Ansary, A (reprint author), King Saud Univ, Coll Sci, Dept Biochem, POB 22452, Riyadh 11495, Saudi Arabia.
EM elansary@ksu.edu.sa
FU Research Center of the Center for Female Scientific and Medical Colleges
   in King Saud University
FX This research project was supported by a grant from the Research Center
   of the Center for Female Scientific and Medical Colleges in King Saud
   University.
CR Aid S, 2005, J NUTR, V135, P1008
   Akbar M, 2005, P NATL ACAD SCI USA, V102, P10858, DOI 10.1073/pnas.0502903102
   Al-Gadani Y, 2009, CLIN BIOCHEM, V42, P1032, DOI 10.1016/j.clinbiochem.2009.03.011
   ANDERSON JW, 1984, P SOC EXP BIOL MED, V177, P372
   Assisi A, 2006, INT CLIN PSYCHOPHARM, V21, P319, DOI 10.1097/01.yic.0000224790.98534.11
   Azavache V, 1998, ARCH LATINOAM NUTR, V48, P216
   Basselin M, 2012, BRAIN RES BULL, V87, P154, DOI 10.1016/j.brainresbull.2011.12.001
   Bazan NG, 2005, BRAIN PATHOL, V15, P159
   BRASS EP, 1986, BIOCHEM J, V236, P131
   Brookes KJ, 2006, BIOL PSYCHIAT, V60, P1053, DOI 10.1016/j.biopsych.2006.04.025
   CHEN WJL, 1984, P SOC EXP BIOL MED, V175, P215
   Chisaguano AM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078245
   Darios F, 2006, NATURE, V440, P813, DOI 10.1038/nature04598
   Das UN, 2002, PERINATAL STRATEGY P
   Das UN., 2010, METABOLIC SYNDROME P
   Das UN, 2011, MOLECULAR BASIS OF HEALTH AND DISEASE, P1, DOI 10.1007/978-94-007-0495-4
   Das Undurti N., 2006, Biotechnology Journal, V1, P420, DOI 10.1002/biot.200600012
   Das UN, 2003, NUTRITION, V19, P62, DOI 10.1016/S0899-9007(02)00852-3
   DEGEORGE JJ, 1987, J BIOL CHEM, V262, P8077
   Dowhan W, 1997, ANNU REV BIOCHEM, V66, P199, DOI 10.1146/annurev.biochem.66.1.199
   El-Ansary AK, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-74
   El-Ansary AK, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-63
   Essa MM, 2013, NEUROTOX RES, V23, P393, DOI 10.1007/s12640-012-9354-3
   FELDER CC, 1990, P NATL ACAD SCI USA, V87, P2187, DOI 10.1073/pnas.87.6.2187
   Fisler JS, 2006, NUTR METABOLISM, V3, DOI 10.1186/1743-7075-3-38
   Fitzpatrick FA, 2001, J CLIN INVEST, V107, P1347, DOI 10.1172/JCI13241
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Foley KA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087072
   Garcia MC, 1997, BRAIN RES, V768, P43, DOI 10.1016/S0006-8993(97)00583-0
   Gilbert KM, 2003, IMMUNOPHARM IMMUNOT, V25, P13, DOI 10.1081/IPH-120018280
   Hajjar T, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-109
   Huuskonen J, 2004, BRIT J PHARMACOL, V141, P874, DOI 10.1038/sj.bjp.0705682
   Jones CR, 1996, J NEUROCHEM, V67, P822
   Kapoor R, 2006, CURR PHARM BIOTECHNO, V7, P531, DOI 10.2174/138920106779116874
   Kong WM, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-12
   Kuperstein F, 2008, J NEUROCHEM, V106, P662, DOI 10.1111/j.1471-4159.2008.05418.x
   Leaf A, 2002, PROSTAG LEUKOTR ESS, V67, P113, DOI 10.1054/plef.407
   Liu TF, 2012, INFLAMMATION, V35, P1676, DOI 10.1007/s10753-012-9484-z
   MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
   Mullen A, 2010, J NUTR BIOCHEM, V21, P444, DOI 10.1016/j.jnutbio.2009.02.008
   Narendran R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046832
   Park JS, 2007, INT IMMUNOPHARMACOL, V7, P70, DOI 10.1016/j.intimp.2006.08.015
   Pepe MS, 2003, STAT EVALUATION MED, V28
   Pettenuzzo LF, 2002, PHARMACOL BIOCHEM BE, V73, P623, DOI 10.1016/S0091-3057(02)00856-0
   Rapoport SI, 2008, J NUTR, V138, P2515
   Remesy C., 1992, DIETARY FIBRE COMPON, P137
   Rousset S, 2004, DIABETES, V54, P130
   Saemann MD, 2000, FASEB J, V14, P2380
   SCHEPPACH W, 1991, CLIN SCI, V80, P177
   Serhan CN, 2011, CURR TOP MED CHEM, V11, P629
   SINGER SJ, 1972, SCIENCE, V175, P720, DOI 10.1126/science.175.4023.720
   STEVENS LJ, 1995, AM J CLIN NUTR, V62, P761
   Thomas RH, 2010, J NEUROCHEM, V113, P515, DOI 10.1111/j.1471-4159.2010.06614.x
   Venkatraman A, 2003, AM J PHYSIOL-GASTR L, V285, pG177, DOI 10.1152/ajpgi.00307.2002
   Vinolo MAR, 2011, J NUTR BIOCHEM, V22, P849, DOI 10.1016/j.jnutbio.2010.07.009
   Vinolo MAR, 2011, NUTRIENTS, V3, P858, DOI 10.3390/nu3100858
   Vreugdenhil M, 1996, P NATL ACAD SCI USA, V93, P12559, DOI 10.1073/pnas.93.22.12559
   Wajner M, 2004, J INHERIT METAB DIS, V27, P427, DOI 10.1023/B:BOLI.0000037353.13085.e2
   Weatherill AR, 2005, J IMMUNOL, V174, P5390
   XIAO YF, 1995, P NATL ACAD SCI USA, V92, P11000, DOI 10.1073/pnas.92.24.11000
   Xiao YF, 2006, AM J PHYSIOL-CELL PH, V290, pC362, DOI 10.1152/ajpcell.00296.2005
   YU NC, 1993, P NATL ACAD SCI USA, V90, P4042, DOI 10.1073/pnas.90.9.4042
NR 62
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD AUG 31
PY 2014
VL 13
AR 140
DI 10.1186/1476-511X-13-140
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AP2HH
UT WOS:000341892800001
PM 25175350
ER

PT J
AU Gerlai, R
AF Gerlai, Robert
TI Social behavior of zebrafish: From synthetic images to biological
   mechanisms of shoaling
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Ontogenesis and mechanisms of shoaling; Social behavior; Zebrafish;
   Alcoholism; Fetal alcohol spectrum disorder
ID AUTISM SPECTRUM DISORDERS; DANIO-RERIO; SEROTONINERGIC SYSTEMS; FISH;
   EXPOSURE; EXPRESSION; BRAIN; MODEL; NEUROCHEMISTRY; QUANTIFICATION
AB The zebrafish strikes a good balance between system complexity and practical simplicity and as a result it is becoming increasingly frequently utilized in biomedical research as a translational tool. Numerous human brain disorders are associated with abnormal social behavior and the zebrafish has been suggested for modeling such disorders. To start this line of research, however, one may need to first thoroughly examine the laboratory organism, zebrafish, and its features, social behavior in this case. Proper methods need be developed to induce and quantify social behavior. These paradigms maybe able to open a window to the brain and facilitate the understanding of the biological mechanisms of social behavior and its abnormalities. This review is based on an oral paper presented at the last Measuring Behavior Conference, and as such it is mainly focused on research conducted in my own laboratory. Tracing the temporal progression of our own work, it discusses questions including what shoaling is, how it can be induced and measured and how it can be utilized in the modeling of certain human brain disorders, for example, alcohol induced abnormalities. (C) 2014 Elsevier B.V. All rights reserved.
C1 Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada.
RP Gerlai, R (reprint author), Univ Toronto, Dept Psychol, 3359 Mississauga Rd North,Rm DV4023C, Mississauga, ON L5L 1C6, Canada.
EM robert_gerlai@yahoo.com
CR Al-Imari L, 2008, BEHAV BRAIN RES, V189, P216, DOI 10.1016/j.bbr.2007.12.007
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Blaser R, 2006, BEHAV RES METHODS, V38, P456, DOI 10.3758/BF03192800
   Brierley AS, 2010, CURR BIOL, V20, P1758, DOI 10.1016/j.cub.2010.08.041
   Buske C, 2012, DEV PSYCHOBIOL, V54, P28, DOI 10.1002/dev.20571
   Buske C, 2011, PROG NEURO-PSYCHOPH, V35, P1409, DOI 10.1016/j.pnpbp.2010.09.003
   Buske C, 2011, NEUROTOXICOL TERATOL, V33, P698, DOI 10.1016/j.ntt.2011.05.009
   Cermak T., 2011, NUCLEIC ACIDS RES, V39, P1
   Chatterjee D, 2014, AMINO ACIDS, V46, P921, DOI 10.1007/s00726-013-1658-y
   Chien WT, 2013, NEUROPSYCH DIS TREAT, V9, P1311, DOI 10.2147/NDT.S37485
   Clark KJ, 2011, ZEBRAFISH, V8, P147, DOI 10.1089/zeb.2011.9993
   Echevarria DJ, 2011, REV NEUROSCIENCE, V22, P85, DOI 10.1515/RNS.2011.010
   Engeszer RE, 2007, ZEBRAFISH, V4, P21, DOI 10.1089/zeb.2006.9997
   Fernandes Y, 2009, ALCOHOL CLIN EXP RES, V33, P601, DOI 10.1111/j.1530-0277.2008.00874.x
   Ford JR, 2013, OECOLOGIA, V172, P387, DOI 10.1007/s00442-012-2508-4
   Gerlai R, 2009, GENES BRAIN BEHAV, V8, P586, DOI 10.1111/j.1601-183X.2009.00488.x
   Gerlai R, 2010, MOLECULES, V15, P2609, DOI 10.3390/molecules15042609
   Gerlai R, 2013, EVOL PSYCHOL, V11, P1
   Gerlai Robert, 2012, Curr Top Behav Neurosci, V12, P3, DOI 10.1007/7854_2011_180
   Gerlai R, 2000, PHARMACOL BIOCHEM BE, V67, P773, DOI 10.1016/S0091-3057(00)00422-6
   KALIVAS PW, 1991, BRAIN RES REV, V16, P223, DOI 10.1016/0165-0173(91)90007-U
   Karnik I, 2012, BEHAV BRAIN RES, V233, P415, DOI 10.1016/j.bbr.2012.05.024
   KENNEDY GJA, 1975, T AM FISH SOC, V104, P454, DOI 10.1577/1548-8659(1975)104<454:EOHISO>2.0.CO;2
   Krause J, 2002, LIVING GROUPS
   Kully-Martens K, 2012, ALCOHOL CLIN EXP RES, V36, P568, DOI 10.1111/j.1530-0277.2011.01661.x
   LANDEAU L, 1986, ANIM BEHAV, V34, P1372, DOI 10.1016/S0003-3472(86)80208-1
   Lenroot RK, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00733
   Mahabir S, 2013, NEUROTOX TERAT C, V41, P1
   Mahabir S, 2013, BEHAV BRAIN RES, V247, P1, DOI 10.1016/j.bbr.2013.03.013
   Miller N, 2007, BEHAV BRAIN RES, V184, P157, DOI 10.1016/j.bbr.2007.07.007
   Miller N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048865
   Miller N, 2012, BEHAV BRAIN RES, V240, P192
   Miller N, 2011, BEHAV RES METHODS, V43, P964, DOI 10.3758/s13428-011-0090-z
   Miller NY, 2008, BEHAV BRAIN RES, V193, P148, DOI 10.1016/j.bbr.2008.05.004
   Miller NY, 2011, REV NEUROSCIENCE, V22, P17, DOI 10.1515/RNS.2011.004
   MORRISON RL, 1987, SCHIZOPHRENIA BULL, V13, P715
   Nakayasu T, 2014, ANIM COGN, V17, P559, DOI 10.1007/s10071-013-0687-y
   Neri P, 2012, ANIM BEHAV, V84, P485, DOI 10.1016/j.anbehav.2012.06.005
   Pan Y, 2011, BEHAV BRAIN RES, V216, P66, DOI 10.1016/j.bbr.2010.07.017
   Pierce RC, 1997, BRAIN RES REV, V25, P192, DOI 10.1016/S0165-0173(97)00021-0
   Pitcher Tony J., 1993, Fish and Fisheries Series, V7, P363
   PITCHER TJ, 1983, ANIM BEHAV, V31, P611, DOI 10.1016/S0003-3472(83)80087-6
   Qin M, 2014, ZEBRAFISH IN PRESS
   RYER CH, 1991, ENVIRON BIOL FISH, V30, P317, DOI 10.1007/BF02028847
   Saif M, 2013, BEHAV BRAIN RES, V243, P294, DOI 10.1016/j.bbr.2013.01.020
   Sampson PD, 1997, TERATOLOGY, V56, P317, DOI 10.1002/(SICI)1096-9926(199711)56:5<317::AID-TERA5>3.0.CO;2-U
   Saverino C, 2008, BEHAV BRAIN RES, V191, P77, DOI 10.1016/j.bbr.2008.03.013
   Scerbina T, 2012, AMINO ACIDS, V43, P2059, DOI 10.1007/s00726-012-1284-0
   Sivasubbu S, 2007, GENOME BIOL S, VS9, P1
   Tchaconas A, 2013, CURR OPIN PEDIATR, V25, P130, DOI 10.1097/MOP.0b013e32835c2b70
   Thoma P, 2013, NEUROSCI BIOBEHAV R, V37, P448, DOI 10.1016/j.neubiorev.2013.01.024
   Tropepe V, 2003, GENES BRAIN BEHAV, V2, P268, DOI 10.1046/j.1601-183X.2003.00038.x
NR 52
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
EI 1872-678X
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD AUG 30
PY 2014
VL 234
SI SI
BP 59
EP 65
DI 10.1016/j.jneumeth.2014.04.028
PG 7
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AO0GE
UT WOS:000340986300007
PM 24793400
ER

PT J
AU Seffer, D
   Schwarting, RKW
   Wohr, M
AF Seffer, Dominik
   Schwarting, Rainer K. W.
   Woehr, Markus
TI Pro-social ultrasonic communication in rats: Insights from playback
   studies
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Ultrasonic communication; Ultrasonic vocalizations; Social behavior;
   Animal model; Autism; Schizophrenia
ID ANXIETY-RELATED BEHAVIOR; RATTUS-NORVEGICUS; SEXUAL-BEHAVIOR; FEMALE
   RATS; STIMULUS CONFIGURATION; CATEGORICAL PERCEPTION; 50-KHZ
   VOCALIZATIONS; JUVENILE RATS; MOUSE MODELS; ALARM CRIES
AB Rodent ultrasonic vocalizations (USV) serve as situation-dependent affective signals and convey important communicative functions. In the rat, three major USV types exist: (I) 40-kHz USV, which are emitted by pups during social isolation: (II) 22-kHz USV, which are produced by juvenile and adult rats in aversive situations, including social defeat: and (III) 50-kHz USV, which are uttered by juvenile and adult rats in appetitive situations, including rough-and-tumble play. Here, evidence for a communicative function of 50-kHz USV is reviewed, focusing on findings obtained in the recently developed 50-kHz USV radial maze playback paradigm. Up to now, the following five acoustic stimuli were tested in this paradigm: (A) natural 50-kHz USV, (B) natural 22-kHz USV, (C) artificial 50-kHz sine wave tones, (D) artificial time- and amplitude-matched white noise, and (E) background noise. All studies using the 50-kHz USV radial maze playback paradigm indicate that 50-kHz USV serve a pro-social affiliative function as social contact calls. While playback of the different kinds of acoustic stimuli used so far elicited distinct behavioral response patterns, 50-kHz USV consistently led to social approach behavior in the recipient, indicating that pro-social ultrasonic communication can be studied in a reliable and highly standardized manner by means of the 50-kHz USV radial maze playback paradigm. This appears to be particularly relevant for rodent models of neurodevelopmental disorders, as there is a tremendous need for reliable behavioral assays with face validity to social communication deficits seen in autism and schizophrenia in order to study underlying genetic and neurobiological alterations. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Seffer, Dominik; Schwarting, Rainer K. W.; Woehr, Markus] Univ Marburg, D-35032 Marburg, Germany.
RP Wohr, M (reprint author), Univ Marburg, Gutenbergstr 18, D-35032 Marburg, Germany.
EM markus.woehr@staff.uni-marburg.de
FU Deutsche Forschungsgemeinschaft [DFG WO 1732/1-1]
FX M.W. is supported by the Deutsche Forschungsgemeinschaft (DFG WO
   1732/1-1).
CR ALLIN JT, 1972, ANIM BEHAV, V20, P175, DOI 10.1016/S0003-3472(72)80189-1
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Bang SJ, 2008, NEUROBIOL LEARN MEM, V90, P200, DOI 10.1016/j.nlm.2008.02.009
   BARFIELD RJ, 1986, ANN NY ACAD SCI, V474, P33, DOI 10.1111/j.1749-6632.1986.tb27996.x
   BARFIELD RJ, 1979, AM ZOOL, V19, P469
   BLANCHARD RJ, 1991, PHYSIOL BEHAV, V50, P967, DOI 10.1016/0031-9384(91)90423-L
   BORDEN R, 1977, B PSYCHONOMIC SOC, V10, P89
   Borta A, 2006, BEHAV BRAIN RES, V166, P271, DOI 10.1016/j.bbr.2005.08.009
   Brudzynski SM, 2002, J COMP PSYCHOL, V116, P73, DOI 10.1037//0735-7036.116.1.73
   Brudzynski SM, 2013, CURR OPIN NEUROBIOL, V23, P310, DOI 10.1016/j.conb.2013.01.014
   Burgdorf J, 2001, BEHAV NEUROSCI, V115, P940, DOI 10.1037//0735-7044.115.4.940
   Burgdorf J, 2009, DEV PSYCHOBIOL, V51, P34, DOI 10.1002/dev.20343
   Burgdorf J, 2011, NEUROSCI BIOBEHAV R, V35, P1831, DOI 10.1016/j.neubiorev.2010.11.011
   Burgdorf J, 2008, J COMP PSYCHOL, V122, P357, DOI 10.1037/a0012889
   Burman OHP, 2007, APPL ANIM BEHAV SCI, V104, P116, DOI 10.1016/j.applanim.2006.04.028
   Choi JS, 2003, J NEUROSCI, V23, P8713
   EHRET G, 1981, NATURWISSENSCHAFTEN, V68, P208, DOI 10.1007/BF01047208
   EHRET G, 1992, ANIM BEHAV, V43, P409, DOI 10.1016/S0003-3472(05)80101-0
   EHRET G, 1982, J COMP PHYSIOL, V148, P245
   Endres T, 2007, BEHAV BRAIN RES, V185, P69, DOI 10.1016/j.bbr.2007.07.012
   Fendt M, 1999, NEUROSCI BIOBEHAV R, V23, P743, DOI 10.1016/S0149-7634(99)00016-0
   Fone KCF, 2008, NEUROSCI BIOBEHAV R, V32, P1087, DOI 10.1016/j.neubiorev.2008.03.003
   GEYER LA, 1978, J COMP PHYSIOL PSYCH, V92, P457, DOI 10.1037/h0077478
   HOFER MA, 1993, BEHAV NEUROSCI, V107, P354, DOI 10.1037//0735-7044.107.2.354
   Kim EJ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015077
   Knutson B, 1998, J COMP PSYCHOL, V112, P65, DOI 10.1037/0735-7036.112.1.65
   Lapiz M D S, 2003, Neurosci Behav Physiol, V33, P13, DOI 10.1023/A:1021171129766
   LeDoux JE, 2000, ANNU REV NEUROSCI, V23, P155, DOI 10.1146/annurev.neuro.23.1.155
   Litvin Y, 2007, BEHAV BRAIN RES, V182, P166, DOI 10.1016/j.bbr.2006.11.038
   Lopuch S, 2011, J COMP PSYCHOL, V125, P250, DOI 10.1037/a0021532
   MCINTOSH TK, 1978, NATURE, V272, P163, DOI 10.1038/272163a0
   Moles A, 2004, SCIENCE, V304, P1983, DOI 10.1126/science.1095943
   Panksepp J, 2000, BEHAV BRAIN RES, V115, P25, DOI 10.1016/S0166-4328(00)00238-2
   Panksepp J, 2002, BEHAV BRAIN SCI, V25, P43
   Panksepp J, 2005, SCIENCE, V308, P62, DOI 10.1126/science.1112066
   Parsana AJ, 2012, BEHAV BRAIN RES, V226, P77, DOI 10.1016/j.bbr.2011.08.040
   Parsana AJ, 2012, BEHAV BRAIN RES, V232, P395, DOI 10.1016/j.bbr.2012.03.031
   Rygula R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051959
   Sadananda M, 2008, NEUROSCI LETT, V435, P17, DOI 10.1016/j.neulet.2008.02.002
   Salchner P, 2004, BEHAV BRAIN RES, V151, P1, DOI 10.1016/j.bbr.2003.07.002
   SALES GD, 1972, ANIM BEHAV, V20, P88, DOI 10.1016/S0003-3472(72)80177-5
   SALES G D, 1972, Journal of Zoology (London), V168, P149
   Santarelli L, 2003, SCIENCE, V301, P805, DOI 10.1126/science.1083328
   Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
   Schwarting RKW, 2007, BEHAV BRAIN RES, V182, P208, DOI 10.1016/j.bbr.2007.01.029
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   SIVIY SM, 1987, DEV PSYCHOBIOL, V20, P39, DOI 10.1002/dev.420200108
   Snoeren EM, 2014, J COMP PSYC IN PRESS
   Snoeren EMS, 2013, BEHAV NEUROSCI, V127, P439, DOI 10.1037/a0032027
   THOMAS DA, 1982, J COMP PHYSIOL PSYCH, V96, P807, DOI 10.1037/h0077919
   THOMAS DA, 1981, J COMP PHYSIOL PSYCH, V95, P630, DOI 10.1037/h0077803
   VANDERSCHUREN LJMJ, 1995, PSYCHOPHARMACOLOGY, V117, P225, DOI 10.1007/BF02245191
   VANDERSCHUREN LJMJ, 1995, EUR J PHARMACOL, V276, P257, DOI 10.1016/0014-2999(95)00040-R
   Webber ES, 2012, BEHAV BRAIN RES, V229, P138, DOI 10.1016/j.bbr.2012.01.012
   White NR, 1993, BEHAV NEURAL BIOL, V59, P16
   WHITE NR, 1989, PHYSIOL BEHAV, V45, P229, DOI 10.1016/0031-9384(89)90123-6
   WHITE NR, 1991, BEHAV NEURAL BIOL, V55, P154, DOI 10.1016/0163-1047(91)80136-3
   WHITE NR, 1990, J COMP PSYCHOL, V104, P255, DOI 10.1037/0735-7036.104.3.255
   WHITE NR, 1990, J COMP PSYCHOL, V104, P140, DOI 10.1037//0735-7036.104.2.140
   WHITE NR, 1987, J COMP PSYCHOL, V101, P73, DOI 10.1037/0735-7036.101.1.73
   Willadsen M, 2014, J COMP PSYC IN PRESS
   Wohr M, 2013, CELL TISSUE RES, V354, P81, DOI 10.1007/s00441-013-1607-9
   Wohr M, 2013, BEHAV BRAIN RES, V251, P5, DOI 10.1016/j.bbr.2013.05.047
   Wohr M, 2009, PHARMACOL BIOCHEM BE, V94, P285, DOI 10.1016/j.pbb.2009.09.008
   Wohr M, 2011, SOC NEUROSCI-UK, V6, P76, DOI 10.1080/17470911003765560
   Wohr M, 2008, ANIM BEHAV, V76, P749, DOI 10.1016/j.anbehav.2008.04.017
   Wohr M, 2012, NEUROBIOL LEARN MEM, V98, P154, DOI 10.1016/j.nlm.2012.05.004
   Wohr M, 2008, PHYSIOL BEHAV, V93, P766, DOI 10.1016/j.physbeh.2007.11.031
   Wohr M, 2005, NEUROBIOL LEARN MEM, V84, P228, DOI 10.1016/j.nlm.2005.07.004
   Wohr M, 2009, NEUROSCIENCE, V163, P1024, DOI 10.1016/j.neuroscience.2009.07.043
   Wohr M, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001365
   Wohr M, 2008, BEHAV NEUROSCI, V122, P310, DOI 10.1037/0735-7044.122.2.310
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
NR 73
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
EI 1872-678X
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD AUG 30
PY 2014
VL 234
SI SI
BP 73
EP 81
DI 10.1016/j.jneumeth.2014.01.023
PG 9
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AO0GE
UT WOS:000340986300009
PM 24508146
ER

PT J
AU Sungur, AO
   Vorckel, KJ
   Schwarting, RKW
   Wohr, M
AF Sungur, A. Oezge
   Voerckel, Karl J.
   Schwarting, Rainer K. W.
   Woehr, Markus
TI Repetitive behaviors in the Shank1 knockout mouse model for autism
   spectrum disorder: Developmental aspects and effects of social context
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Animal model; Neurodevelopmental disorders; Postsynaptic density;
   Repetitive behavior; Marble burying; Self-grooming
ID SCAFFOLDING PROTEIN SHANK3; FEMALE HOUSE MICE; ULTRASONIC VOCALIZATIONS;
   PSYCHIATRIC-DISORDERS; SYNAPTIC-TRANSMISSION; SCENT-MARKING;
   SEX-PHEROMONE; MUS-MUSCULUS; MUTANT MICE; MUTATIONS
AB Background: Autism spectrum disorder (ASD) is characterized by persistent deficits in social behavior and communication, together with restricted and repetitive patterns of behavior. Several ASD candidate genes have been identified, including the SHANK gene family with its three family members SHANK1, SHANK2, and SHANK3.
   Methods: Typically, repetitive behavior in mouse models for ASD is assessed by measuring self-grooming behavior. The first aim of the current study was to assess repetitive behaviors in Shank1(-/-) null mutant, Shank1(+/-) heterozygous, and Shank1(+/+) wildtype littermate control mice by means of a comprehensive approach, including the assessment of self-grooming, digging behavior, and marble burying. The second aim was to establish a test paradigm that allows for assessing the effects of social context on the occurrence of repetitive behaviors in a genotype-dependent manner. To this aim, repetitive behaviors were repeatedly tested on three consecutive days in distinct social contexts, namely in presence or absence of social odors.
   Results: Shank1(+/-) heterozygous and to a lesser extent Shank1(-/-) null mutant mice displayed slightly elevated levels of self-grooming behavior as adults, but not as juveniles, with genotype differences being most prominent in the social context. In contrast to elevated self-grooming behavior, marble burying was strongly reduced in adult Shank1(+/-) heterozygous and Shank1(-/-) null mutant mice across social contexts, as compared to adult Shank1(+/+) wildtype littermate controls.
   Conclusion: The opposite effects of the Shank1 deletion on the two types of repetitive behaviors are in line with a number of studies on repetitive behaviors in other genetic Shank models. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Sungur, A. Oezge; Voerckel, Karl J.; Schwarting, Rainer K. W.; Woehr, Markus] Philipps Univ Marburg, D-35032 Marburg, Germany.
RP Wohr, M (reprint author), Philipps Univ Marburg, Gutenbergstr 18, D-35032 Marburg, Germany.
EM markus.woehr@staff.uni-marburg.de
FU German Research Foundation (Deutsche Forschungsgemeinschaft) [DFG WO
   1732/1-1]
FX This work was supported by a grant by the German Research Foundation
   (Deutsche Forschungsgemeinschaft) to M.W. (DFG WO 1732/1-1). The authors
   wish to thank Jacqueline Crawley, University of California Davis School
   of Medicine, and the Howard Hughes Medical Institute investigators
   Albert Hung and Morgan Sheng for providing the Shank1 mouse line. The
   authors also wish to thank Clara Krzikalla and Max Rollwage for their
   help in data acquisition.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Arakawa H, 2008, NEUROSCI BIOBEHAV R, V32, P1236, DOI 10.1016/j.neubiorev.2008.05.012
   ASENDORPF J, 1980, Z EXP ANGEW PSYCHOL, V27, P44
   BARONCOHEN S, 1989, BRIT J CLIN PSYCHOL, V28, P193
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Bienvenu OJ, 2009, AM J MED GENET B, V150B, P710, DOI 10.1002/ajmg.b.30897
   Bishop SL, 2011, AUTISM RES, V4, P317, DOI 10.1002/aur.216
   Boccuto L, 2013, EUR J HUM GENET, V21, P310, DOI 10.1038/ejhg.2012.175
   Carruthers P., 1996, THEORIES THEORIES MI, P257
   Dhar SU, 2010, AM J MED GENET A, V152A, P573, DOI 10.1002/ajmg.a.33253
   DIZINNO G, 1978, BEHAV BIOL, V22, P104, DOI 10.1016/S0091-6773(78)92094-1
   Drapeau E, 2014, DIS MODEL M IN PRESS
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Ebert DH, 2013, NATURE, V493, P327, DOI 10.1038/nature11860
   Ecker C, 2013, MOL PSYCHIATR, V18, P435, DOI 10.1038/mp.2012.102
   FOLSTEIN S, 1977, NATURE, V265, P726, DOI 10.1038/265726a0
   Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
   Gauthier J, 2010, P NATL ACAD SCI USA, V107, P7863, DOI 10.1073/pnas.0906232107
   Gong XH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034739
   Grabrucker AM, 2011, TRENDS CELL BIOL, V21, P594, DOI 10.1016/j.tcb.2011.07.003
   Guilmatre A, 2014, DEV NEUROBIOL, V74, P113, DOI 10.1002/dneu.22128
   Guo ZS, 2007, CHEM SENSES, V32, P463, DOI 10.1093/chemse/bjm015
   Hammerschmidt K, 2009, BIOL LETTERS, V5, P589, DOI 10.1098/rsbl.2009.0317
   Han K, 2013, NATURE, V503, P72, DOI 10.1038/nature12630
   Hung AY, 2008, J NEUROSCI, V28, P1697, DOI 10.1523/JNEUROSCI.3032-07.2008
   Jiang YH, 2013, NEURON, V78, P8, DOI 10.1016/j.neuron.2013.03.016
   Jones RM, 2013, BEHAV BRAIN RES, V251, P113, DOI 10.1016/j.bbr.2012.10.037
   Kim EJ, 2004, NAT REV NEUROSCI, V5, P771, DOI 10.1038/nrn1517
   Kouser M, 2013, J NEUROSCI, V33, P18448, DOI 10.1523/JNEUROSCI.3017-13.2013
   Kreienkamp H-J., 2008, V186, P365
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   MAGGIO JC, 1983, PHYSIOL BEHAV, V31, P269, DOI 10.1016/0031-9384(83)90186-5
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
   Moy SS, 2014, BEHAV BRAIN RES, V259, P200, DOI 10.1016/j.bbr.2013.10.052
   Muehlmann AM, 2012, BEHAV BRAIN RES, V235, P143, DOI 10.1016/j.bbr.2012.07.041
   Murphy D, 2012, NAT REV DRUG DISCOV, V11, P815, DOI 10.1038/nrd3881
   NYBY J, 1983, BEHAV NEURAL BIOL, V38, P32, DOI 10.1016/S0163-1047(83)90354-0
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Phelan MC, 2008, ORPHANET J RARE DIS, V3, DOI 10.1186/1750-1172-3-14
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   POMERANTZ SM, 1983, PHYSIOL BEHAV, V31, P91, DOI 10.1016/0031-9384(83)90101-4
   Posthuma D, 2013, CURR OPIN NEUROL, V26, P111, DOI 10.1097/WCO.0b013e32835f19c3
   Roullet FI, 2011, BEHAV BRAIN RES, V216, P19, DOI 10.1016/j.bbr.2010.06.004
   Ryan BC, 2010, BEHAV BRAIN RES, V208, P178, DOI 10.1016/j.bbr.2009.11.031
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Sheng M, 2000, J CELL SCI, V113, P1851
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Silverman JL, 2011, BRAIN RES, V1380, P120, DOI 10.1016/j.brainres.2010.09.026
   SIPOS ML, 1995, PHYSIOL BEHAV, V58, P529, DOI 10.1016/0031-9384(95)00089-2
   SIPOS ML, 1992, BEHAV NEURAL BIOL, V58, P138, DOI 10.1016/0163-1047(92)90375-E
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Ting JT, 2012, ANNU REV NEUROSCI, V35, P49, DOI 10.1146/annurev-neuro-062111-150442
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   Waga C, 2011, PSYCHIAT GENET, V21, P208, DOI 10.1097/YPG.0b013e328341e069
   Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
   Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104
   Wilson HL, 2003, J MED GENET, V40, P575, DOI 10.1136/jmg.40.8.575
   Wohr M, 2013, BEHAV BRAIN RES, V251, P5, DOI 10.1016/j.bbr.2013.05.047
   Wohr M, 2014, NEUROSCI BIOBEHAV R, V43, P199, DOI 10.1016/j.neubiorev.2014.03.021
   Wohr M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020631
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
   Yoo J, 2013, PHILOS T R SOC LON B, V369
NR 70
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
EI 1872-678X
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD AUG 30
PY 2014
VL 234
SI SI
BP 92
EP 100
DI 10.1016/j.jneumeth.2014.05.003
PG 9
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AO0GE
UT WOS:000340986300011
PM 24820912
ER

PT J
AU Riedel, A
   Maier, S
   Ulbrich, M
   Biscaldi, M
   Ebert, D
   Fangmeier, T
   Perlov, E
   van Elst, LT
AF Riedel, Andreas
   Maier, Simon
   Ulbrich, Melanie
   Biscaldi, Monica
   Ebert, Dieter
   Fangmeier, Thomas
   Perlov, Evgeniy
   van Elst, Ludger Tebartz
TI No significant brain volume decreases or increases in adults with
   high-functioning autism spectrum disorder and above average
   intelligence: A voxel-based morphometric study
SO PSYCHIATRY RESEARCH-NEUROIMAGING
LA English
DT Article
DE Autism spectrum disorder (ASD); Asperger's syndrome; Voxel-based
   morphometry (VBM); High IQ
ID ROSTRAL PREFRONTAL CORTEX; LIKELIHOOD ESTIMATION; DIAGNOSTIC INTERVIEW;
   SEX-DIFFERENCES; METAANALYSIS; VERSION; MATTER; SCALE; MRI;
   ABNORMALITIES
AB Autism spectrum disorder (ASD) is increasingly being recognized as an important issue in adult psychiatry and psychotherapy. High intelligence indicates overall good brain functioning and might thus present a particularly good opportunity to study possible cerebral correlates of core autistic features in terms of impaired social cognition, communication skills, the need for routines, and circumscribed interests. Anatomical MRI data sets for 30 highly intelligent patients with high-functioning autism and 30 pairwise-matched control subjects were acquired and analyzed with voxel-based morphometry. The gray matter volume of the pairwise-matched patients and the controls did not differ significantly. When correcting for total brain volume influences, the patients with ASD exhibited smaller left superior frontal volumes on a trend level. Heterogeneous volumetric findings in earlier studies might partly be explained by study samples biased by a high inclusion rate of secondary forms of ASD, which often go along with neuronal abnormalities. Including only patients with high IQ scores might have decreased the influence of secondary forms of ASD and might explain the absence of significant volumetric differences between the patients and the controls in this study. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Riedel, Andreas; Ulbrich, Melanie; Ebert, Dieter; Fangmeier, Thomas; Perlov, Evgeniy; van Elst, Ludger Tebartz] Univ Freiburg, Clin Psychiat & Psychotherapy, Sect Expt Neuropsychiat, D-79104 Freiburg, Germany.
   [Riedel, Andreas; Ebert, Dieter; Fangmeier, Thomas; van Elst, Ludger Tebartz] Univ Freiburg, Clin Psychiat & Psychotherapy, Univ Zentrum Autismus Spektrum, D-79104 Freiburg, Germany.
   [Maier, Simon; van Elst, Ludger Tebartz] Univ Med Ctr Freiburg, Freiburg Brain Imaging, D-79106 Freiburg, Germany.
   [Maier, Simon] Univ Freiburg, Inst Biol 3, Fac Biol, D-79104 Freiburg, Germany.
   [Biscaldi, Monica] Univ Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-79104 Freiburg, Germany.
RP Maier, S (reprint author), Univ Med Ctr Freiburg, Freiburg Brain Imaging, Breisacher Str 64, D-79106 Freiburg, Germany.
EM simon.maier@uniklinik-freiburg.de
FU Federal Ministry of Education and Research [BMBF 01GV0606]
FX We thank Christoph Kaller for providing help and codes for the pair-wise
   matching procedure. Part of the study was supported by a grant from the
   Federal Ministry of Education and Research to LTVE (BMBF 01GV0606 to
   LTvE).
CR Aitken K.J., 2010, A Z GENETIC FACTORS
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Angelidou A, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-89
   Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
   Aylward EH, 2002, NEUROLOGY, V59, P175
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Beacher FD, 2012, AM J NEURORADIOL, V33, P83, DOI 10.3174/ajnr.A2880
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561
   Bigler ED, 2010, DEV NEUROPSYCHOL, V35, P278, DOI 10.1080/87565641003696817
   Bolton PF, 2001, LANCET, V358, P726, DOI 10.1016/S0140-6736(01)05903-7
   Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
   Bunge SA, 2009, NEUROIMAGE, V46, P338, DOI 10.1016/j.neuroimage.2009.01.064
   Burgess PW, 2007, TRENDS COGN SCI, V11, P290, DOI 10.1016/j.tics.2007.05.004
   Cauda F, 2011, J NEUROL NEUROSUR PS, V82, P1304, DOI 10.1136/jnnp.2010.239111
   Chen R., 2011, PEDIATR RES, V69, P63
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Creten C, 2011, LANCET, V378, P98, DOI 10.1016/S0140-6736(11)60548-5
   Duerden EG, 2012, AUTISM RES, V5, P49, DOI 10.1002/aur.235
   Dumontheil I, 2008, DEV MED CHILD NEUROL, V50, P168, DOI 10.1111/j.1469-8749.2008.02026.x
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Fangmeier T, 2011, NERVENARZT, V82, P628, DOI 10.1007/s00115-010-3121-6
   Friston K, 2007, STATISTICAL PARAMETRIC MAPPING: THE ANALYSIS OF FUNCTIONAL BRAIN IMAGES, P1
   Gilbert SJ, 2006, J COGNITIVE NEUROSCI, V18, P932, DOI 10.1162/jocn.2006.18.6.932
   Greimel E., 2012, BRAIN STRUCTURE FUNC, V218, P929
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   LEHRL S, 1995, ACTA NEUROL SCAND, V91, P335
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   McLaren DG, 2010, METHODS, V50, P157, DOI 10.1016/j.ymeth.2009.10.003
   Melfsen S, 2005, Z KINDER JUG-PSYCH, V33, P27, DOI 10.1024/1422-4917.33.1.27
   Moreno-De-Luca A, 2013, LANCET NEUROL, V12, P406, DOI 10.1016/S1474-4422(13)70011-5
   Nichols TE, 2002, HUM BRAIN MAPP, V15, P1, DOI 10.1002/hbm.1058
   Nickl-Jockschat T, 2012, HUM BRAIN MAPP, V33, P1470, DOI 10.1002/hbm.21299
   Radua J, 2011, PSYCHOL MED, V41, P1539, DOI 10.1017/S0033291710002187
   Raven J, 2000, COGNITIVE PSYCHOL, V41, P1, DOI 10.1006/cogp.1999.0735
   Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   Retz-Junginger P, 2002, NERVENARZT, V73, P830, DOI 10.1007/s00115-001-1215-x
   Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040
   Sparks BF, 2002, NEUROLOGY, V59, P184
   van Elst LT, 2013, EUR ARCH PSY CLIN N, V263, pS189, DOI 10.1007/s00406-013-0459-3
   Tebartz van Elst L., 2012, ASPERGER SYNDROM ERW
   Toal F, 2010, PSYCHOL MED, V40, P1171, DOI 10.1017/S0033291709991541
   Via E, 2011, ARCH GEN PSYCHIAT, V68, P409, DOI 10.1001/archgenpsychiatry.2011.27
   Vorst HCM, 2001, PERS INDIV DIFFER, V30, P413, DOI 10.1016/S0191-8869(00)00033-7
   Williams JHG, 2005, NEUROIMAGE, V25, P133, DOI 10.1016/j.neuroimage.2004.10.047
   Wilson LB, 2009, PSYCHIAT RES-NEUROIM, V174, P138, DOI 10.1016/j.pscychresns.2009.04.013
NR 53
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0925-4927
EI 1872-7506
J9 PSYCHIAT RES-NEUROIM
JI Psychiatry Res. Neuroimaging
PD AUG 30
PY 2014
VL 223
IS 2
BP 67
EP 74
DI 10.1016/j.pscychresns.2014.05.013
PG 8
WC Clinical Neurology; Neuroimaging; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AM6ZK
UT WOS:000340014300003
PM 24953998
ER

PT J
AU Chantiluke, K
   Christakou, A
   Murphy, CM
   Giampietro, V
   Daly, EM
   Ecker, C
   Brammer, M
   Murphy, DG
   Rubia, K
AF Chantiluke, Kaylita
   Christakou, Anastasia
   Murphy, Clodagh M.
   Giampietro, Vincent
   Daly, Eileen M.
   Ecker, Christina
   Brammer, Michael
   Murphy, Declan G.
   Rubia, Katya
CA MRC Aims Consortium
TI Disorder-specific functional abnormalities during temporal discounting
   in youth with Attention Deficit Hyperactivity Disorder (ADHD), Autism
   and comorbid ADHD and Autism
SO PSYCHIATRY RESEARCH-NEUROIMAGING
LA English
DT Article
DE ADHD; Autism; ASD; fMRI; Temporal discounting
ID DEFICIT/HYPERACTIVITY DISORDER; DECISION-MAKING; SPECTRUM DISORDERS;
   BRAIN ACTIVATION; FMRI; CHILDREN; METAANALYSIS; POPULATION; BEHAVIOR;
   CORTEX
AB Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share cognitive abnormalities in temporal foresight. A key question is whether shared cognitive phenotypes are based on common or different underlying pathophysiologies and whether comorbid patients have, additive neurofunctional deficits, resemble one of the disorders or have a different pathophysiology. We compared age- and IQ-matched boys with non-comorbid ADHD (18), non-comorbid ASD (15), comorbid ADHD and ASD (13) and healthy controls (18) using functional magnetic resonance imaging (fMRI) during a temporal discounting task. Only the ASD and the comorbid groups discounted delayed rewards more steeply. The fMRI data showed both shared and disorder-specific abnormalities in the three groups relative to controls in their brain-behaviour associations. The comorbid group showed both unique and more severe brain-discounting associations than controls and the non-comorbid patient groups in temporal discounting areas of ventromedial and lateral prefrontal cortex, ventral striatum and anterior cingulate, suggesting that comorbidity is neither an endophenocopy of the two pure disorders nor an additive pathology. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
C1 [Chantiluke, Kaylita; Murphy, Clodagh M.] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London WC2R 2LS, England.
   [Murphy, Clodagh M.; Daly, Eileen M.; Ecker, Christina; Murphy, Declan G.; Rubia, Katya] Kings Coll London, Inst Psychiat, Sackler Inst Translat Neurodev, London WC2R 2LS, England.
   [Murphy, Clodagh M.; Daly, Eileen M.; Ecker, Christina; Murphy, Declan G.; Rubia, Katya] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London WC2R 2LS, England.
   [Giampietro, Vincent; Brammer, Michael] Kings Coll London, Inst Psychiat, Dept Neuroimaging, London WC2R 2LS, England.
   [Christakou, Anastasia] Univ Reading, Ctr Integrat Neurosci & Neurodynam, Reading, Berks, England.
   [Christakou, Anastasia] Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, England.
RP Rubia, K (reprint author), MRC Ctr Social Genet & Dev Psychiat SGDP, Dept Child Psychiat, Inst Psychiat, PO46,16 De Crespigny Pk, London SE5 8AF, England.
EM katya.rubia@kcl.ac.uk
RI Williams, Steve/D-6979-2011; Ecker, Christine/E-5194-2010; Bailey,
   Anthony/J-2860-2014
OI Bailey, Anthony/0000-0003-4257-972X
FU Medical Research Council [MRC GO300155]; MRC UK Autism Imaging
   Multicentre Study [G0400061]; MRC [G0300155]; Institute of Psychiatry,
   King's College London
FX This study was supported by Grants from the Medical Research Council
   (MRC GO300155) to Prof. Katya Rubia and the MRC UK Autism Imaging
   Multicentre Study (G0400061) to Prof. Declan Murphy. Dr. Anastasia
   Christakou was supported by a post-doctoral fellowship from MRC
   G0300155. Kaylita Chantiluke was supported by a Ph.D. studentship from
   the Institute of Psychiatry, King's College London.
CR Brammer MJ, 1997, MAGN RESON IMAGING, V15, P763, DOI 10.1016/S0730-725X(97)00135-5
   Bullmore ET, 1999, IEEE T MED IMAGING, V18, P32, DOI 10.1109/42.750253
   Bullmore ET, 2001, HUM BRAIN MAPP, V12, P61, DOI 10.1002/1097-0193(200102)12:2<61::AID-HBM1004>3.0.CO;2-W
   Bush G, 2002, P NATL ACAD SCI USA, V99, P523, DOI 10.1073/pnas.012470999
   Cardinal RN, 2006, NEURAL NETWORKS, V19, P1277, DOI 10.1016/j.neunet.2006.03.004
   Christakou A, 2013, MOL PSYCHIATR, V18, P236, DOI 10.1038/mp.2011.185
   Christakou A, 2011, NEUROIMAGE, V54, P1344, DOI 10.1016/j.neuroimage.2010.08.067
   Conners CK, 1998, J ABNORM CHILD PSYCH, V26, P257, DOI 10.1023/A:1022602400621
   Critchfield TS, 2001, J APPL BEHAV ANAL, V34, P101, DOI 10.1901/jaba.2001.34-101
   Cubillo A, 2012, CORTEX, V48, P194, DOI 10.1016/j.cortex.2011.04.007
   Demurie E, 2012, DEVELOPMENTAL SCI, V15, P791, DOI 10.1111/j.1467-7687.2012.01178.x
   Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
   Goodman R, 1999, J ABNORM CHILD PSYCH, V27, P17, DOI 10.1023/A:1022658222914
   Hart H, 2013, JAMA PSYCHIAT, V70, P185, DOI 10.1001/jamapsychiatry.2013.277
   Hart H, 2012, NEUROSCI BIOBEHAV R, V36, P2248, DOI 10.1016/j.neubiorev.2012.08.003
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Kalenscher T, 2006, INT J PSYCHOPHYSIOL, V62, P203, DOI 10.1016/j.ijpsycho.2006.05.010
   Kim S, 2011, BIOL PSYCHIAT, V69, P1140, DOI 10.1016/j.biopsych.2010.07.005
   Kochhar P, 2011, CHILD CARE HLTH DEV, V37, P103, DOI 10.1111/j.1365-2214.2010.01123.x
   Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1
   Kohls G, 2013, SOC COGN AFFECT NEUR, V8, P565, DOI 10.1093/scan/nss033
   Lemiere J, 2012, BRAIN RES, V1450, P57, DOI 10.1016/j.brainres.2012.02.027
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luhmann CC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.039.2009
   Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P277, DOI 10.1016/j.rasd.2011.05.009
   Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4
   Nakao T, 2011, AM J PSYCHIAT, V168, P1154, DOI 10.1176/appi.ajp.2011.11020281
   Noreika V, 2013, NEUROPSYCHOLOGIA, V51, P235, DOI 10.1016/j.neuropsychologia.2012.09.036
   Odum AL, 2011, BEHAV PROCESS, V87, P1, DOI 10.1016/j.beproc.2011.02.007
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Peters J, 2011, TRENDS COGN SCI, V15, P227, DOI 10.1016/j.tics.2011.03.002
   Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
   Plichta MM, 2009, BIOL PSYCHIAT, V65, P7, DOI 10.1016/j.biopsych.2008.07.008
   Plichta MM, 2014, NEUROSCI BIOBEHAV R, V38, P125, DOI 10.1016/j.neubiorev.2013.07.012
   Richards JB, 1999, J EXP ANAL BEHAV, V71, P121, DOI 10.1901/jeab.1999.71-121
   Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
   Rubia K, 2009, PHILOS T R SOC B, V364, P1919, DOI 10.1098/rstb.2009.0014
   Rubia K, 2014, EXPERT REV NEUROTHER, V14, P519, DOI 10.1586/14737175.2014.907526
   Scheres A, 2010, BIOL PSYCHIAT, V67, P641, DOI 10.1016/j.biopsych.2009.10.033
   Scheres A, 2006, NEUROPSYCHOLOGIA, V44, P2092, DOI 10.1016/j.neuropsychologia.2005.10.012
   Scheres A, 2008, J NEURAL TRANSM, V115, P221, DOI 10.1007/s00702-007-0813-6
   Shaw P, 2013, BIOL PSYCHIAT, V74, P599, DOI 10.1016/j.biopsych.2013.04.007
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Talairach J., 1988, COPLANAR STEREOTAXIC
   Thirion B, 2007, NEUROIMAGE, V35, P105, DOI 10.1016/j.neuroimage.2006.11.054
   Tye C, 2013, DEV COGN NEUROS-NETH, V5, P71, DOI 10.1016/j.dcn.2013.01.001
   van der Meer JMJ, 2012, J AM ACAD CHILD PSY, V51, P1160, DOI 10.1016/j.jaac.2012.08.024
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wittmann M, 2007, EXP BRAIN RES, V179, P643, DOI 10.1007/s00221-006-0822-y
   World Health Organisation, 1994, CLASS MENT BEH DIS C
NR 53
TC 3
Z9 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0925-4927
EI 1872-7506
J9 PSYCHIAT RES-NEUROIM
JI Psychiatry Res. Neuroimaging
PD AUG 30
PY 2014
VL 223
IS 2
BP 113
EP 120
DI 10.1016/j.pscychresns.2014.04.006
PG 8
WC Clinical Neurology; Neuroimaging; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AM6ZK
UT WOS:000340014300008
PM 24929553
ER

PT J
AU Papadopoulos, N
   McGinley, JL
   Bradshaw, JL
   Rinehart, NJ
AF Papadopoulos, Nicole
   McGinley, Jennifer L.
   Bradshaw, John L.
   Rinehart, Nicole J.
TI An investigation of gait in children with Attention Deficit
   Hyperactivity Disorder: A case controlled study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE ADHD; Autism; Gait; Social-communication disturbance; Inattention
ID HIGH-FUNCTIONING AUTISM; ASPERGERS-DISORDER; DEFICIT/HYPERACTIVITY
   DISORDER; MOTOR; ADHD; PERFORMANCE; TASK; DISTURBANCE; CEREBELLUM; BOYS
AB This study aimed to compare the gait of children with ADHD - Combined Type (ADHD-CT) to typically developing (TD) children. Children with ADHD-CT (n=14; mean age 10 years 4 months) and a TD group (n=13; mean age 10 years 9 months) walked at self-selected slow, preferred and fast speed on an electronic walkway system. Participants completed a total of 15 walking trials; 5 trials per walking condition. Groups were matched on age, intellectual functioning, height and weight. In the preferred walking condition, there was no difference in spatio-temporal gait variables between the ADHD-CT and TD control groups. At self-selected fast speed, children with ADHD-CT were faster and walked with a higher cadence. The subtle alterations in gait pattern that may reflect a timing deficit is consistent with previous ADHD motor studies. In addition, this study extends previous studies in characterising the unique gait profile of non-medicated children with ADHD-CT where a diagnosis of autism spectrum disorder has been ruled out. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Papadopoulos, Nicole; Bradshaw, John L.; Rinehart, Nicole J.] Monash Univ, Ctr Dev Psychiat & Psychol, Sch Psychol & Psychiat, Clayton, Vic 3800, Australia.
   [McGinley, Jennifer L.] Univ Melbourne, Melbourne, Vic 3010, Australia.
   [McGinley, Jennifer L.] Southern Hlth, Clin Res Ctr Movement & Gait Disorders, Clayton, Vic, Australia.
   [Papadopoulos, Nicole; Rinehart, Nicole J.] Deakin Univ, Sch Psychol, Deakin Child Study Ctr, Burwood, Vic 3125, Australia.
RP Papadopoulos, N (reprint author), Deakin Univ, Sch Psychol, Burwood Campus,Melbourne Burwood Campus, Burwood, Vic 3125, Australia.
EM Nicole.Papadopoulos@deakin.edu.au
CR Ambrosini D., 1998, GAIT POSTURE, V7, P188, DOI 10.1016/S0966-6362(98)90288-0
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barkley RA, 2001, NEUROPSYCHOL REV, V11, P1, DOI 10.1023/A:1009085417776
   Berquin PC, 1998, NEUROLOGY, V50, P1087
   Bradshaw J.L., 2001, DEV DISORDERS FRONTO
   Brossard-Racine M, 2012, RES DEV DISABIL, V33, P2080, DOI 10.1016/j.ridd.2012.06.003
   Buderath P, 2009, GAIT POSTURE, V29, P249, DOI 10.1016/j.gaitpost.2008.08.016
   Calhoun M, 2011, CLIN BIOMECH, V26, P200, DOI 10.1016/j.clinbiomech.2010.09.013
   Conners CK, 2001, CONNERS RATING SCALE
   Constantino J., 2005, SOCIAL RESPONSIVE SC
   Diamond A, 2000, CHILD DEV, V71, P44, DOI 10.1111/1467-8624.00117
   Einfeld S. L., 2002, MANUAL DEV BEHAV CHE
   EINFELD SL, 1995, J AUTISM DEV DISORD, V25, P81, DOI 10.1007/BF02178498
   Hart H, 2012, NEUROSCI BIOBEHAV R, V36, P2248, DOI 10.1016/j.neubiorev.2012.08.003
   Harvey W.J., 1997, ADAPTED PHYS ACTIVIT, V14, P190
   Harvey WJ, 2003, ADAPT PHYS ACT Q, V20, P1
   Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
   HOF AL, 1996, GAIT POSTURE, V4, P222, DOI 10.1016/0966-6362(95)01057-2
   Ivry R B, 1989, J Cogn Neurosci, V1, P136, DOI 10.1162/jocn.1989.1.2.136
   Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019
   Leitner Y, 2007, J NEUROL, V254, P1330, DOI 10.1007/s00415-006-0522-3
   Luman M, 2009, J ABNORM CHILD PSYCH, V37, P1123, DOI 10.1007/s10802-009-9334-0
   Nayate A, 2012, J AUTISM DEV DISORD, V42, P707, DOI 10.1007/s10803-011-1299-5
   Nobile M, 2011, AUTISM, V15, P263, DOI 10.1177/1362361309356929
   Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
   Papadopoulos N., 2012, J ATTENTION DISORDER
   Papadopoulos N, 2012, RES AUTISM SPECT DIS, V6, P286, DOI 10.1016/j.rasd.2011.05.010
   Papadopoulos N, 2012, AUTISM, V16, P627, DOI 10.1177/1362361311418692
   Piek JP, 1999, DEV MED CHILD NEUROL, V41, P159, DOI 10.1017/S0012162299000341
   Pitcher TM, 2003, DEV MED CHILD NEUROL, V45, P525
   Qiu AQ, 2010, J AM ACAD CHILD PSY, V49, P539, DOI 10.1016/j.jaac.2010.02.012
   Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
   Reiersen AM, 2008, J AM ACAD CHILD PSY, V47, P662, DOI 10.1097/CHI.0b013e31816bff88
   Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
   Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
   Rinehart NJ, 2006, DEV MED CHILD NEUROL, V48, P819, DOI 10.1017/S0012162206001769
   Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
   Teitelbaum O, 2004, P NATL ACAD SCI USA, V101, P11909, DOI 10.1073/pnas.0403919101
   Valera EM, 2010, BIOL PSYCHIAT, V68, P359, DOI 10.1016/j.biopsych.2010.05.012
   WECHSLER D., 2005, MANUAL WECHSLER INTE
   Wechsler D, 1999, WASI WECHSLER ABBREV
NR 41
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2014
VL 218
IS 3
BP 319
EP 323
DI 10.1016/j.psychres.2014.04.037
PG 5
WC Psychiatry
SC Psychiatry
GA AK7GZ
UT WOS:000338598000009
PM 24837426
ER

PT J
AU Corbett, BA
   Newsom, C
   Key, AP
   Qualls, LR
   Edmiston, EK
AF Corbett, Blythe A.
   Newsom, Cassandra
   Key, Alexandra P.
   Qualls, Lydia R.
   Edmiston, E. Kale
TI Examining the relationship between face processing and social
   interaction behavior in children with and without autism spectrum
   disorder
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Play; Ecological validity; Neuropsychology;
   Face memory
ID ECOLOGICAL VALIDITY; FACIAL EXPRESSIONS; RECOGNITION; EMOTIONS; BRAIN;
   ADOLESCENTS; MOTIVATION; COGNITION; CORTISOL; IDENTITY
AB Background: Children with autism spectrum disorder (ASD) show impairment in reciprocal social communication, which includes deficits in social cognition and behavior. Since social cognition and social behavior are considered to be interdependent, it is valuable to examine social processes on multiple levels of analysis. Neuropsychological measures of face processing often reveal deficits in social cognition in ASD including the ability to identify and remember facial information. However, the extent to which neuropsychological measures are associated with or predictive of real-world social behavior is unclear.
   Methods: The study investigated 66 children (ASD 34, typically developing (TD) 32) using neuropsychological measures of face processing (identity, affect, and memory). Children also participated in a peer interaction paradigm, which allowed observation and coding of natural social interaction behaviors during play with peers (e. g., Self-Play, Cooperative Play, Verbal Bout). ANCOVA, regression, and correlation models analyzed between-group differences, the ability of neuropsychological measures to predict social behavior, and the strength of the associations.
   Results: Between-group differences were shown on Memory for Faces Delayed and the peer interaction variables Self-Play and Verbal Bout. Regression models indicated that Memory for Faces Delayed predicted the amount of Self-Play, Equipment use alone, and Cooperative Play with peers on the playground. Autism symptomology only predicted verbal exchange with peers.
   Conclusions: Face memory strongly predicts relevant social engagement patterns in both children with and without ASD. Impairment in facial memory is associated with reduced 'real-world' social interaction and more self-play, whereas higher performance in face memory predicts more cooperative play. Results highlight the strong connection between face memory and reciprocal social interaction, suggesting that improvement in one may benefit the other.
C1 [Corbett, Blythe A.; Newsom, Cassandra; Qualls, Lydia R.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA.
   [Corbett, Blythe A.; Newsom, Cassandra; Key, Alexandra P.; Qualls, Lydia R.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37203 USA.
   [Corbett, Blythe A.] Vanderbilt Univ, Dept Psychol, Nashville, TN 37203 USA.
   [Newsom, Cassandra] Vanderbilt Univ, Dept Pediat, Nashville, TN 37203 USA.
   [Key, Alexandra P.] Vanderbilt Univ, Dept Hearing & Speech Sci, Nashville, TN 37203 USA.
   [Edmiston, E. Kale] Vanderbilt Univ, Vanderbilt Brain Inst, Nashville, TN 37203 USA.
RP Corbett, BA (reprint author), Vanderbilt Univ, Dept Psychiat, PMB 40,230 Appleton Pl, Nashville, TN 37203 USA.
EM blythe.corbett@vanderbilt.edu
FU National Institute of Mental Health (NIMH) [MH085717]; National
   Institute of Child Development (NICHD) [P30 HD15052]; CTSA award,
   National Center for Advancing Translational Sciences [UL1TR000445]
FX The study was funded by a grant from the National Institute of Mental
   Health (NIMH) MH085717 awarded to Blythe Corbett, a grant from the
   National Institute of Child Development (NICHD) P30 HD15052 awarded to
   the Vanderbilt Kennedy Center and a CTSA award No. UL1TR000445 from the
   National Center for Advancing Translational Sciences. The NIMH and NICHD
   did not have any involvement in the design; in the collection, analysis,
   and interpretation of data; in the writing of the report; and in the
   decision to submit the article for publication.
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Adolphs R, 1999, TRENDS COGN SCI, V3, P469, DOI 10.1016/S1364-6613(99)01399-6
   American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Arkush L, 2013, AUTISM RES, V6, P550, DOI 10.1002/aur.1318
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bookheimer SY, 2008, J INT NEUROPSYCH SOC, V14, P922, DOI 10.1017/S135561770808140X
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   BRAVERMAN M, 1989, J AUTISM DEV DISORD, V19, P301, DOI 10.1007/BF02211848
   CAMPBELL DT, 1959, PSYCHOL BULL, V56, P81, DOI 10.1037/h0046016
   Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
   Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
   Chayton N, 2003, NEUROPSYCHOL REV, V13, P118
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Corbett BA, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-13
   Corbett BA, 2011, J AUTISM DEV DISORD, V41, P505, DOI 10.1007/s10803-010-1064-1
   Corbett BA, 2014, J CHILD PSYCHOL PSYC, V55, P924, DOI 10.1111/jcpp.12184
   Corbett BA, 2014, AUTISM RES, V7, P4, DOI 10.1002/aur.1341
   Corbett BA, 2008, ASSESSMENT AUTISM SP, P253
   Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
   Franzen MD, 1996, ECOLOGICAL VALIDITY, P91
   Gioia GA, 2004, DEV NEUROPSYCHOL, V25, P135, DOI 10.1207/s15326942dn2501&2_8
   Greene DJ, 2011, NEUROIMAGE, V56, P354, DOI 10.1016/j.neuroimage.2011.02.031
   Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
   Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Hauck M, 1998, CHILD NEUROPSYCHOL, V4, P187, DOI 10.1076/chin.4.3.187.3174
   Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724
   HOBSON RP, 1988, PSYCHOL MED, V18, P911
   HOLM S, 1979, SCAND J STAT, V6, P65
   Hooper SR, 2006, CHILD NEUROPSYCHOL, V12, P299, DOI 10.1080/09297040600737984
   Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
   Kennedy DP, 2012, TRENDS COGN SCI, V16, P559, DOI 10.1016/j.tics.2012.09.006
   Kennedy DP, 2012, NEUROPSYCHOLOGIA, V50, P3313, DOI 10.1016/j.neuropsychologia.2012.09.038
   Key APF, 2012, DEV COGN NEUROS-NETH, V2, P244, DOI 10.1016/j.dcn.2011.12.003
   Key AP, 2014, DEV NEUROPSYCHOL, V39, P474, DOI 10.1080/87565641.2014.940620
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
   Korkman M., 2007, NEPSY
   Krebs JF, 2011, J AUTISM DEV DISORD, V41, P796, DOI 10.1007/s10803-010-1098-4
   Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   Lanni KE, 2012, AUTISM, V16, P123, DOI 10.1177/1362361311425916
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   LORD C, 1995, DEV PSYCHOPATHOL, V7, P611
   Lyons D., 1990, AM J PRIMATOL, V20, P209
   Noldus, 2008, OBSERVER XT
   Olson K, 2013, APPL NEUROPSYCH-CHIL, V2, P17, DOI 10.1080/21622965.2012.686330
   Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
   Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   PETERSEN AC, 1988, J YOUTH ADOLESCENCE, V17, P117, DOI 10.1007/BF01537962
   Price KJ, 2003, CLIN NEUROPSYCHOL, V17, P170, DOI 10.1076/clin.17.2.170.16506
   Rabin LA, 2007, CLIN NEUROPSYCHOL, V21, P727, DOI 10.1080/13854040600888776
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sbordone R., 2010, PSYCHOL INJ LAW, V3, P63, DOI DOI 10.1007/S12207-010-9066-Z
   Sbordone R. J., 1996, ECOLOGICAL VALIDITY, P15
   Schupp CW, 2013, J AUTISM DEV DISORD, V43, P2405, DOI 10.1007/s10803-013-1790-2
   Spooner DM, 2006, ARCH CLIN NEUROPSYCH, V21, P327, DOI 10.1016/j.acn.2006.04.004
   Teufel C, 2013, FRONT INTEGR NEUROSC, V6, P128
   Webb SJ, 2010, CHILD NEUROPSYCHOL, V16, P255, DOI 10.1080/09297041003601454
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
   Westfall PH, 2011, MULTIPLE COMP MULTIP
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
NR 68
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD AUG 29
PY 2014
VL 6
AR 35
DI 10.1186/1866-1955-6-35
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO2PK
UT WOS:000341167000001
PM 25180050
ER

PT J
AU Nankova, BB
   Agarwal, R
   MacFabe, DF
   La Gamma, EF
AF Nankova, Bistra B.
   Agarwal, Raj
   MacFabe, Derrick F.
   La Gamma, Edmund F.
TI Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene
   Expression, Including CREB-Dependent Catecholaminergic
   Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum
   Disorders
SO PLOS ONE
LA English
DT Article
ID CHAIN FATTY-ACIDS; TYROSINE-HYDROXYLASE GENE; GLUTATHIONE REDOX
   IMBALANCE; RAT DISTAL COLON; VALPROIC ACID; RODENT MODEL;
   NEURODEVELOPMENTAL DISORDERS; HISTONE-DEACETYLASE; GUT MICROBIOTA;
   MESSENGER-RNA
AB Alterations in gut microbiome composition have an emerging role in health and disease including brain function and behavior. Short chain fatty acids (SCFA) like propionic (PPA), and butyric acid (BA), which are present in diet and are fermentation products of many gastrointestinal bacteria, are showing increasing importance in host health, but also may be environmental contributors in neurodevelopmental disorders including autism spectrum disorders (ASD). Further to this we have shown SCFA administration to rodents over a variety of routes (intracerebroventricular, subcutaneous, intraperitoneal) or developmental time periods can elicit behavioral, electrophysiological, neuropathological and biochemical effects consistent with findings in ASD patients. SCFA are capable of altering host gene expression, partly due to their histone deacetylase inhibitor activity. We have previously shown BA can regulate tyrosine hydroxylase (TH) mRNA levels in a PC12 cell model. Since monoamine concentration is known to be elevated in the brain and blood of ASD patients and in many ASD animal models, we hypothesized that SCFA may directly influence brain monoaminergic pathways. When PC12 cells were transiently transfected with plasmids having a luciferase reporter gene under the control of the TH promoter, PPA was found to induce reporter gene activity over a wide concentration range. CREB transcription factor(s) was necessary for the transcriptional activation of TH gene by PPA. At lower concentrations PPA also caused accumulation of TH mRNA and protein, indicative of increased cell capacity to produce catecholamines. PPA and BA induced broad alterations in gene expression including neurotransmitter systems, neuronal cell adhesion molecules, inflammation, oxidative stress, lipid metabolism and mitochondrial function, all of which have been implicated in ASD. In conclusion, our data are consistent with a molecular mechanism through which gut related environmental signals such as increased levels of SCFA's can epigenetically modulate cell function further supporting their role as environmental contributors to ASD.
C1 [Nankova, Bistra B.; Agarwal, Raj; La Gamma, Edmund F.] Maria Fareri Childrens Hosp, Dept Pediat, New York Med Coll, Valhalla, NY 10595 USA.
   [MacFabe, Derrick F.] Univ Western Ontario, Kilee Patchell Evans Autism Res Grp, Dept Psychol Neurosci, London, ON, Canada.
   [MacFabe, Derrick F.] Univ Western Ontario, Dept Psychiat, Div Dev Disabil, London, ON N6A 3K7, Canada.
RP Nankova, BB (reprint author), Maria Fareri Childrens Hosp, Dept Pediat, New York Med Coll, Valhalla, NY 10595 USA.
EM bistra_nankova@nymc.edu
FU Children's Research Foundation; Children's and Women's Physicians of
   Westchester (CWPW); GoodLife's Children's Foundation; Autism Research
   Institute
FX Children's Research Foundation and Children's and Women's Physicians of
   Westchester (CWPW) to BN and ELG; GoodLife's Children's Foundation and
   Autism Research Institute to DM. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Adams JB, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-22
   Al-Ghamdi M, 2014, BMC NEUROSCI, V15, DOI 10.1186/1471-2202-15-34
   Al-Lahham SH, 2010, BBA-MOL CELL BIOL L, V1801, P1175, DOI 10.1016/j.bbalip.2010.07.007
   Amminger GP, 2007, BIOL PSYCHIAT, V61, P551, DOI 10.1016/j.biopsych.2006.05.007
   Aneja A, 2008, INT REV PSYCHIATR, V20, P165, DOI 10.1080/09540260801889062
   Aranyi T, 2007, BIOCHEM BIOPH RES CO, V359, P15, DOI 10.1016/j.bbrc.2007.05.025
   Bell JG, 2004, PROSTAG LEUKOTR ESS, V71, P201, DOI 10.1016/j.plefa.2004.03.008
   Bell JG, 2000, PROSTAG LEUKOTR ESS, V63, P21, DOI 10.1054/plef.2000.0186
   Bensinger SJ, 2008, NATURE, V454, P470, DOI 10.1038/nature07202
   Bergersen L, 2002, NEUROCHEM RES, V27, P89, DOI 10.1023/A:1014806723147
   Boccuto L, 2013, EUR J HUM GENET, V21, P310, DOI 10.1038/ejhg.2012.175
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1006/abio.1976.9999
   Brown AJ, 2003, J BIOL CHEM, V278, P11312, DOI 10.1074/jbc.M211609200
   Brusque AM, 1999, PHARMACOL BIOCHEM BE, V64, P529, DOI 10.1016/S0091-3057(99)00127-6
   Canani RB, 2011, WORLD J GASTROENTERO, V17, P1519, DOI [10.3748/wjg.v17.i12. 1519, 10.3748/wjg.v17.i12.1519]
   Carlezon WA, 2005, TRENDS NEUROSCI, V28, P436, DOI 10.1016/j.tins.2005.06.005
   Chauhan A, 2012, NEUROCHEM RES, V37, P1681, DOI 10.1007/s11064-012-0775-4
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Chen JS, 2003, CURR CANCER DRUG TAR, V3, P219, DOI 10.2174/1568009033481994
   Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063
   Christensen J, 2013, JAMA-J AM MED ASSOC, V309, P1696, DOI 10.1001/jama.2013.2270
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Cohen OS, 2013, INT J DEV NEUROSCI, V31, P740, DOI 10.1016/j.ijdevneu.2013.09.002
   CONN AR, 1983, AM J PHYSIOL, V245, pE253
   COULTER DL, 1991, J CHILD NEUROL, V6, P7, DOI 10.1177/088307389100600102
   Cuche G, 1999, NEUROGASTROENT MOTIL, V11, P219
   de Theije CGM, 2011, EUR J PHARMACOL, V668, pS70, DOI 10.1016/j.ejphar.2011.07.013
   DeCastro M, 2005, MOL BRAIN RES, V142, P28, DOI 10.1016/j.molbrainres.2005.09.002
   de Theije CGM, 2014, BRAIN BEHAV IMMUN, V37, P197, DOI 10.1016/j.bbi.2013.12.005
   Devine DP, 2012, METHODS MOL BIOL, V829, P65, DOI 10.1007/978-1-61779-458-2_4
   Dichter GS, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-19
   D'Souza A, 2009, BRAIN RES, V1247, P1, DOI 10.1016/j.brainres.2008.09.088
   Ebert SN, 1997, MOL BRAIN RES, V47, P24, DOI 10.1016/S0169-328X(97)00032-6
   Ekins S, 2007, METH MOL B, V356, P319
   El-Ansary AK, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-74
   FADER D, 1990, MOL BRAIN RES, V8, P25, DOI 10.1016/0169-328X(90)90005-X
   Fatemi SH, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-6
   Feliz Brady, 2003, Arch Pathol Lab Med, V127, pe325
   Fenton WA, 2001, METABOLIC MOL BASES, P2165
   Finegold SM, 2011, ANAEROBE, V17, P367, DOI 10.1016/j.anaerobe.2011.03.007
   Foley KA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087072
   Foley KA, 2014, INT J DEV NEUROSCI
   Frye RE, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.14
   Frye RE, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2012.143
   Ganapathy V, 2013, CURR OPIN PHARM
   Gottlicher M, 2001, EMBO J, V20, P6969, DOI 10.1093/emboj/20.24.6969
   GREENE LA, 1976, P NATL ACAD SCI USA, V73, P2424, DOI 10.1073/pnas.73.7.2424
   Griswold AJ, 2012, HUM MOL GENET, V21, P3513, DOI 10.1093/hmg/dds164
   Guilloteau P, 2010, NUTR RES REV, V23, P366, DOI 10.1017/S0954422410000247
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harrington RA, 2013, AUTISM RES, V6, P149, DOI 10.1002/aur.1288
   HEERDT BG, 1994, CANCER RES, V54, P3288
   Heerdt BG, 1998, CANCER RES, V58, P2869
   Heerdt BG, 1997, CELL GROWTH DIFFER, V8, P523
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
   Inoue D, 2012, FEBS LETT, V586, P1547, DOI 10.1016/j.febslet.2012.04.021
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
   Johannessen M, 2004, CELL SIGNAL, V16, P1211, DOI 10.1016/j.cellsig.2004.05.001
   Jones LL, 2010, PROG LIPID RES, V49, P61, DOI 10.1016/j.plipres.2009.08.004
   Jones MB, 2004, AM J MED GENET B, V126B, P58, DOI 10.1002/ajmg.b.20172
   Karaki S, 2006, CELL TISSUE RES, V324, P353, DOI 10.1007/s00441-005-0140-x
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Kim KC, 2011, TOXICOL LETT, V201, P137, DOI 10.1016/j.toxlet.2010.12.018
   Kimura I, 2011, P NATL ACAD SCI USA, V108, P8030, DOI 10.1073/pnas.1016088108
   Kolker S, 2013, J INHERIT METAB DIS, V36, P635, DOI 10.1007/s10545-013-9600-8
   Kumer SC, 1996, J NEUROCHEM, V67, P443
   Kvetnansky R, 2009, PHYSIOL REV, V89, P535, DOI 10.1152/physrev.00042.2006
   LAKE CR, 1977, ARCH GEN PSYCHIAT, V34, P553
   Langley Brett, 2005, Current Drug Targets - CNS and Neurological Disorders, V4, P41, DOI 10.2174/1568007053005091
   Leckman JF, 2002, BIOL PSYCHIAT, V51, P27, DOI 10.1016/S0006-3223(01)01277-X
   Lenartowski R, 2011, INT J DEV NEUROSCI, V29, P873, DOI 10.1016/j.ijdevneu.2011.07.006
   Le Poul E, 2003, J BIOL CHEM, V278, P25481, DOI 10.1074/jbc.M301403200
   Lippiello PM, 2006, MED HYPOTHESES, V66, P985, DOI 10.1016/j.mehy.2005.11.015
   Macfabe Derrick, 2013, Glob Adv Health Med, V2, P52, DOI 10.7453/gahmj.2013.089
   MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
   MacFabe DF, 2011, BEHAV BRAIN RES, V217, P47, DOI 10.1016/j.bbr.2010.10.005
   Macfabe DF, 2012, MICROB ECOL HLTH DIS, V23
   Mally P, 2004, PEDIATR RES, V55, P847, DOI 10.1203/01.PDR.0000119365.21770.45
   Mariadason JM, 2000, CANCER RES, V60, P4561
   Marks PA, 2000, J NATL CANCER I, V92, P1210, DOI 10.1093/jnci/92.15.1210
   Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003
   McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
   McManus CM, 2002, AM J VET RES, V63, P295, DOI 10.2460/ajvr.2002.63.295
   Meguid NA, 2008, CLIN BIOCHEM, V41, P1044, DOI 10.1016/j.clinbiochem.2008.05.013
   Mitsui R, 2005, JPN J PHYSIOL, V55, P331, DOI 10.2170/jjphysiol.RP000205
   Mitsui R, 2005, NEUROGASTROENT MOTIL, V17, P585, DOI 10.1111/j.1365-2982.2005.00669.x
   MORTENSEN FV, 1990, GUT, V31, P1391, DOI 10.1136/gut.31.12.1391
   Nakasato A, 2008, BRAIN RES, V1193, P128, DOI 10.1016/j.brainres.2007.11.043
   Nankova BB, 2003, PEDIATR RES, V53, P1
   Narita N, 2002, PEDIATR RES, V52, P576, DOI 10.1203/01.PDR.0000028406.01104.76
   Nguyen NHT, 2007, J NEUROCHEM, V101, P806, DOI 10.1111/j.1471-4159.2006.04397.x
   Niederman R, 1997, CRIT REV ORAL BIOL M, V8, P269
   Niehus R, 2006, J DEV BEHAV PEDIATR, V27, pS120, DOI 10.1097/00004703-200604002-00010
   Nikolsky Y, 2005, DRUG DISCOV TODAY, V10, P653, DOI 10.1016/S1359-6446(05)03420-3
   Ossenkopp KP, 2012, BEHAV BRAIN RES, V227, P134, DOI 10.1016/j.bbr.2011.10.045
   Parab S, 2007, BRAIN RES, V1132, P42, DOI 10.1016/j.brainres.2006.11.013
   Patel P, 2005, DEV BRAIN RES, V160, P53, DOI 10.1016/j.devbrainres.2005.08.005
   Pearl PL, 2003, NEUROLOGY, V60, P1413
   Pettenuzzo LF, 2002, PHARMACOL BIOCHEM BE, V73, P623, DOI 10.1016/S0091-3057(02)00856-0
   Phiel CJ, 2001, J BIOL CHEM, V276, P36734, DOI 10.1074/jbc.M101287200
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Richardson AJ, 2004, PROSTAG LEUKOTR ESS, V70, P383, DOI 10.1016/j.plefa.2003.12.020
   Robinson PD, 2001, AM J MED GENET, V100, P30, DOI 10.1002/ajmg.1187
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Sabban EL, 1997, SEMIN CELL DEV BIOL, V8, P101, DOI 10.1006/scdb.1996.0129
   Sanduja S, 2011, WIRES RNA, V2, P42, DOI 10.1002/wrna.28
   Schilderink R, 2013, Front Immunol, V4, P226, DOI 10.3389/fimmu.2013.00226
   Schulpis KH, 2001, EPILEPSIA, V42, P1359, DOI 10.1046/j.1528-1157.2001.47000.x
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   SHAFER TJ, 1991, NEUROTOXICOLOGY, V12, P473
   Shah P, 2006, BRAIN RES, V1107, P13, DOI 10.1016/j.brainres.2006.05.097
   Shultz SR, 2009, BEHAV BRAIN RES, V200, P33, DOI 10.1016/j.bbr.2008.12.023
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Stilling RM, 2014, GENES BRAIN BEHAV, V13, P69, DOI 10.1111/gbb.12109
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tamiji J, 2010, NEUROSIGNALS, V18, P98, DOI 10.1159/000323189
   Tana C, 2010, NEUROGASTROENT MOTIL, V22, P512, DOI 10.1111/j.1365-2982.2009.01427.x
   Thomas RH, 2010, J NEUROCHEM, V113, P515, DOI 10.1111/j.1471-4159.2010.06614.x
   Thomas RH, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-153
   Vancassel S, 2001, PROSTAG LEUKOTR ESS, V65, P1, DOI 10.1054/plef.2001.0281
   Waldecker M, 2008, J NUTR BIOCHEM, V19, P587, DOI 10.1016/j.jnutbio.2007.08.002
   Wang L, 2012, DIGEST DIS SCI, V57, P2096, DOI 10.1007/s10620-012-2167-7
   Wang L, 2014, BIOMARK MED, V8, P331, DOI 10.2217/bmm.14.12
   Wang S, 2011, P NATL ACAD SCI USA, V108, P3047, DOI DOI 10.1073/PNAS.1010529108
   Wiest MM, 2009, PROSTAG LEUKOTR ESS, V80, P221, DOI 10.1016/j.plefa.2009.01.007
   Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
   Yorifuji T, 2002, HUM GENET, V111, P161, DOI 10.1007/s00439-002-0761-z
   Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015
   Zhu Wei-Guo, 2003, Current Medicinal Chemistry - Anti-Cancer Agents, V3, P187, DOI 10.2174/1568011033482440
   Zia MT, 2004, NEUROREPORT, V15, P1177, DOI 10.1097/01.wnr.0000126215.79493.56
   Zouboulis C C, 2005, Exp Dermatol, V14, P143, DOI 10.1111/j.0906-6705.2005.0285a.x
NR 134
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 29
PY 2014
VL 9
IS 8
AR e103740
DI 10.1371/journal.pone.0103740
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO2EE
UT WOS:000341127500014
PM 25170769
ER

PT J
AU Yu, QW
   Peng, Y
   Mishra, V
   Ouyang, A
   Li, H
   Zhang, H
   Chen, M
   Liu, SW
   Huang, H
AF Yu, Qiaowen
   Peng, Yun
   Mishra, Virendra
   Ouyang, Austin
   Li, Hang
   Zhang, Hong
   Chen, Min
   Liu, Shuwei
   Huang, Hao
TI Microstructure, length, and connection of limbic tracts in normal human
   brain development
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE limbic tract; development; trajectory; length; microstructure; DTI;
   connectivity; free water elimination
ID RESTING-STATE NETWORKS; OBSESSIVE-COMPULSIVE DISORDER; ANTERIOR
   CINGULATE CORTEX; WHITE-MATTER MATURATION; CENTRAL-NERVOUS-SYSTEM;
   DEFAULT MODE NETWORK; DIFFUSION-TENSOR; STRUCTURAL CONNECTIVITY;
   FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE
AB The cingulum and fornix play an important role in memory, attention, spatial orientation, and feeling functions. Both microstructure and length of these limbic tracts can be affected by mental disorders such as Alzheimer's disease, depression, autism, anxiety, and schizophrenia. To date, there has been little systematic characterization of their microstructure, length, and functional connectivity in normally developing brains. In this study, diffusion tensor imaging (DTI) and resting state functional MRI (rs-fMRI) data from 65 normally developing right-handed subjects from birth to young adulthood was acquired. After cingulate gyrus part of the cingulum (cgc), hippocampal part of the cingulum (cgh) and fornix (fx) were traced with DTI tractography, absolute and normalized tract lengths and DTI-derived metrics including fractional anisotropy, mean, axial, and radial diffusivity were measured for traced limbic tracts. Free water elimination (EWE) algorithm was adopted to improve accuracy of the measurements of DTI-derived metrics. The role of these limbic tracts in the functional network at birth and adulthood was explored. We found a logarithmic age-dependent trajectory for EWE-corrected DTI metric changes with fast increase of microstructural integrity from birth to 2 years old followed by a slow increase to 25 years old. Normalized tract length of cgc increases with age, while no significant relationship with age was found for normalized tract lengths of cgh and fx. Stronger microstructural integrity on the left side compared to that of the right side was found. With integrated DTI and rs-fMRI, the key connectional role of cgc and cgh in the default mode network was confirmed as early as birth. Systematic characterization of length and DTI metrics after EWE correction of limbic tracts offers insight into their morphological and microstructural developmental trajectories. These trajectories may serve as a normal reference for pediatric patients with mental disorders.
C1 [Yu, Qiaowen; Liu, Shuwei] Shandong Univ, Sch Med, Res Ctr Sect & Imaging Anat, Shandong Prov Key Lab Mental Disorders, Jinan 250012, Shandong, Peoples R China.
   [Yu, Qiaowen; Mishra, Virendra; Ouyang, Austin; Huang, Hao] Univ Texas SW Med Ctr Dallas, Adv Imag Res Ctr, Dallas, TX 75390 USA.
   [Peng, Yun; Li, Hang; Zhang, Hong] Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Beijing, Peoples R China.
   [Chen, Min] Univ Texas Dallas, Dept Math Sci, Richardson, TX 75083 USA.
   [Huang, Hao] Univ Texas SW Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA.
RP Liu, SW (reprint author), Shandong Univ, Sch Med, Res Ctr Sect & Imaging Anat, Shandong Prov Key Lab Mental Disorders, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
EM liusw@sdu.edu.cn; hao.huang@utsouthwestern.edu
FU NIH [MH092535, MH092535-S1]; Natural Science Foundation of China
   [31271161, 31071050]; Specialized Research Fund for the Doctoral Program
   of Higher Education of China [20120131130008]
FX This study is sponsored by NIH (MH092535 and MH092535-S1), Natural
   Science Foundation of China (Grant Nos. 31271161 and 31071050), and
   Specialized Research Fund for the Doctoral Program of Higher Education
   of China (No. 20120131130008).
CR Abramowitz JS, 2009, LANCET, V374, P491, DOI 10.1016/S0140-6736(09)60240-3
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Basser PJ, 2000, MAGNET RESON MED, V44, P625, DOI 10.1002/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O
   BASSER PJ, 1994, J MAGN RESON SER B, V103, P247, DOI 10.1006/jmrb.1994.1037
   Baumann N, 2001, PHYSIOL REV, V81, P871
   Beaulieu C, 2002, NMR BIOMED, V15, P435, DOI 10.1002/nbm.782
   BRAAK H, 1991, ACTA NEUROPATHOL, V82, P239
   Catani M, 2002, NEUROIMAGE, V17, P77, DOI 10.1006/nimg.2002.1136
   Catani M, 2013, NEUROSCI BIOBEHAV R, V37, P1724, DOI 10.1016/j.neubiorev.2013.07.001
   Conturo TE, 1999, P NATL ACAD SCI USA, V96, P10422, DOI 10.1073/pnas.96.18.10422
   Deoni SCL, 2011, J NEUROSCI, V31, P784, DOI 10.1523/JNEUROSCI.2106-10.2011
   DeRubeis RJ, 2008, NAT REV NEUROSCI, V9, P788, DOI 10.1038/nrn2345
   Doria V, 2010, P NATL ACAD SCI USA, V107, P20015, DOI 10.1073/pnas.1007921107
   Dubois J, 2008, HUM BRAIN MAPP, V29, P14, DOI 10.1002/hbm.20363
   Duman RS, 2012, TRENDS NEUROSCI, V35, P47, DOI 10.1016/j.tins.2011.11.004
   Fair DA, 2008, P NATL ACAD SCI USA, V105, P4028, DOI 10.1073/pnas.0800376105
   Fitzgerald KD, 2005, BIOL PSYCHIAT, V57, P287, DOI 10.1016/j.biopsych.2004.10.038
   Fransson P, 2009, PEDIATR RES, V66, P301, DOI 10.1203/PDR.0b013e3181b1bd84
   Fransson P, 2007, P NATL ACAD SCI USA, V104, P15531, DOI 10.1073/pnas.0704380104
   Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101
   Gong GL, 2005, HUM BRAIN MAPP, V24, P92, DOI 10.1002/hbm.20072
   Greicius MD, 2009, CEREB CORTEX, V19, P72, DOI 10.1093/cercor/bhn059
   Grieve SM, 2011, NEUROIMAGE, V55, P868, DOI 10.1016/j.neuroimage.2010.12.087
   Hermoye L, 2006, NEUROIMAGE, V29, P493, DOI 10.1016/j.neuroimage.2005.08.017
   Huang H, 2011, NEUROPSYCHOPHARMACOL, V36, P684, DOI 10.1038/npp.2010.199
   Huang H, 2004, MAGNET RESON MED, V52, P559, DOI 10.1002/mrm.20147
   Huang H, 2013, CEREB CORTEX, DOI [10.1093/cercor/bht335, DOI 10.1093/CERCOR/BHT335]
   Huang H, 2012, NEUROBIOL AGING, V33, P2029, DOI 10.1016/j.neurobiolaging.2011.06.027
   Jiang HY, 2006, COMPUT METH PROG BIO, V81, P106, DOI 10.1016/j.cmpb.2005.08.004
   Jones DK, 1999, MAGNET RESON MED, V42, P37, DOI 10.1002/(SICI)1522-2594(199907)42:1<37::AID-MRM7>3.0.CO;2-O
   Jones DK, 1999, MAGNET RESON MED, V42, P515, DOI 10.1002/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q
   KINNEY HC, 1988, J NEUROPATH EXP NEUR, V47, P217, DOI 10.1097/00005072-198805000-00003
   Lebel C, 2011, J NEUROSCI, V31, P10937, DOI 10.1523/JNEUROSCI.5302-10.2011
   Leech R, 2014, BRAIN, V137, P12, DOI 10.1093/brain/awt162
   Mesulam MM, 2000, PRINCIPLES BEHAV COG, P1
   Mishra V, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00721
   Monkul ES, 2007, MOL PSYCHIATR, V12, P360, DOI 10.1038/sj.mp.4001919
   Mori S, 1999, ANN NEUROL, V45, P265, DOI 10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3
   Mukherjee P, 2008, AM J NEURORADIOL, V29, P843, DOI 10.3174/ajnr.A1052
   Mukherjee P, 2001, RADIOLOGY, V221, P349, DOI 10.1148/radiol.2212001702
   Neil JJ, 1998, RADIOLOGY, V209, P57
   Oishi K, 2012, J NEUROIMAGING, V22, P365, DOI 10.1111/j.1552-6569.2011.00633.x
   Oishi Kenichi, 2011, Front Neurol, V2, P54, DOI 10.3389/fneur.2011.00054
   Pasternak O, 2009, MAGN RESON MED, V62, P717, DOI 10.1002/mrm.22055
   Pierpaoli C, 1996, MAGNET RESON MED, V36, P893, DOI 10.1002/mrm.1910360612
   REYNOLDS GP, 1983, NATURE, V305, P527, DOI 10.1038/305527a0
   Saxena K, 2012, J CHILD ADOL PSYCHOP, V22, P112, DOI 10.1089/cap.2011.0063
   Smyser CD, 2010, CEREB CORTEX, V20, P2852, DOI 10.1093/cercor/bhq035
   Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267
   Supekar K, 2010, NEUROIMAGE, V52, P290, DOI 10.1016/j.neuroimage.2010.04.009
   TORREY EF, 1974, LANCET, V2, P942
   Uddin LQ, 2009, HUM BRAIN MAPP, V30, P625, DOI 10.1002/hbm.20531
   van den Heuvel M, 2008, J NEUROSCI, V28, P10844, DOI 10.1523/JNEUROSCI.2964-08.2008
   van den Heuvel MP, 2009, HUM BRAIN MAPP, V30, P3127, DOI 10.1002/hbm.20737
   van Veen V, 2001, NEUROIMAGE, V14, P1302, DOI 10.1006/nimg.2001.0923
   Verhoeven JS, 2010, HUM BRAIN MAPP, V31, P470, DOI 10.1002/hbm.20880
   Wakana S, 2007, NEUROIMAGE, V36, P630, DOI 10.1016/j.neuroimage.2007.02.049
   Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042
   White T, 2008, SCHIZOPHRENIA BULL, V34, P18, DOI 10.1093/schbul/sbm110
   White T, 2007, SCHIZOPHR RES, V90, P302, DOI 10.1016/j.schres.2006.09.032
   Woods RP, 1998, J COMPUT ASSIST TOMO, V22, P139, DOI 10.1097/00004728-199801000-00027
   Yakovlev P. I., 1967, REGIONAL DEV BRAIN E, P3
NR 62
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD AUG 28
PY 2014
VL 6
AR 228
DI 10.3389/fnagi.2014.00228
PG 13
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA AN9NT
UT WOS:000340934400001
PM 25221509
ER

PT J
AU Weinstein, TAR
   Bales, KL
   Maninger, N
   Hostetler, CM
   Capitanio, JP
AF Weinstein, Tamara A. R.
   Bales, Karen L.
   Maninger, Nicole
   Hostetler, Caroline M.
   Capitanio, John P.
TI Early involvement in friendships predicts later plasma concentrations of
   oxytocin and vasopressin in juvenile rhesus macaques (Macaca mulatta)
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE affiliation; friendship; oxytocin; rhesus macaque; social behavior;
   vasopressin
ID MALE PRAIRIE VOLES; AUTISM SPECTRUM DISORDERS;
   CORTICOTROPIN-RELEASING-FACTOR; WILD FEMALE BABOONS; SEX-DIFFERENCES;
   ARGININE-VASOPRESSIN; INTRANASAL OXYTOCIN; SOCIAL SUPPORT;
   MICROTUS-OCHROGASTER; DEVELOPMENTAL EXPOSURE
AB The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) are involved in social bonding in attachment relationships, but their role in friendship is poorly understood. We investigated whether rhesus macaques' (Macaca mulatta) friendships at age one predicted plasma OT and AVP at two later time points. Subjects were 54 rhesus macaques at the California National Primate Research Center (CNPRC). Blood was drawn during a brief capture-and-release in the home cage, and plasma assayed for OT and AVP using an enzyme immunoassay (EIA). Separate linear mixed models for each sex tested the effects of dominance rank, age, sampling time point, housing condition, parturition status, two blood draw timing measures, and five friendship types: proximity friendships, play friendships, reciprocal friendships (a preference for a peer that also preferred the subject), multiplex friendships (friendships displayed in more than one behavioral domain), and total number of friendships. Females' number of reciprocal and play friendships at age one significantly predicted later OT, additionally, these two friendship types interacted with rank, such that high-ranking females with the fewest friendships had the highest OT concentrations. Friendship did not predict later OT levels in males, however proximity, play, reciprocal, and total number of friendships predicted males' plasma AVP. Play and total number of friendships also tended to predict AVP in females. Our results show that peripheral measures of neuroendocrine functioning in juvenile rhesus monkeys are influenced by early involvement in friendships. Friendships have an especially strong impact on an individual's psychosocial development, and our data suggest OT and AVP as potential underlying mechanisms. Moreover, sex differences in the functioning of the OT and AVP systems, and their relation to friendship, may have important clinical implications for the use of OT as a therapeutic, as well as informing the social context in which it is administered.
C1 [Weinstein, Tamara A. R.; Bales, Karen L.; Maninger, Nicole; Hostetler, Caroline M.; Capitanio, John P.] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA.
   [Hostetler, Caroline M.] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA.
RP Weinstein, TAR (reprint author), Univ Calif Davis, Calif Natl Primate Res Ctr, 1 Shields Ave, Davis, CA 95616 USA.
EM tarweinstein@ucdavis.edu
FU NIH [RR00169, RR019970, MH20006, HD053555, HD071998]; NSF; Good Nature
   Institute
FX We are very grateful to Laura Del Rosso, Erna Tarara., Isabel
   Shelton-Mottsmith, Christine Brennan, Katie Hinde, and Susie Kang for
   assisting with data collection, and to the CNPRC animal care staff for
   their help with Mood sampling, animal identification, and accommodating
   our research schedule. This work was supported by NIH grant RR00169 to
   the CNPRC and NIH grant RR019970 to John P. Capitanio. While conducting
   this research, Tamara A. R. Weinstein was supported by the NSF Graduate
   Research Fellowship and by the NIH training grant MH20006. During the
   writing of this paper, Karen L. Bales was funded by NIH grants HD053555
   and HD071998, and the Good Nature Institute.
CR Aguilera G, 2011, EXP GERONTOL, V46, P90, DOI 10.1016/j.exger.2010.08.023
   ALEXANDER SL, 1991, ENDOCRINOLOGY, V128, P65
   AMICO JA, 1981, J CLIN ENDOCR METAB, V52, P988
   Anagnostou E, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-16
   Atzil S, 2012, J AM ACAD CHILD PSY, V51, P798, DOI 10.1016/j.jaac.2012.06.008
   Bagwell CL, 1998, CHILD DEV, V69, P140, DOI 10.1111/j.1467-8624.1998.tb06139.x
   Bakermans-Kranenburg MJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.34
   Bales KL, 2013, BIOL PSYCHIAT, V74, P180, DOI 10.1016/j.biopsych.2012.08.025
   Bales KL, 2004, PHYSIOL BEHAV, V81, P519, DOI 10.1016/j.physbeh.2004.02.016
   Bales KL, 2004, DEV PSYCHOBIOL, V44, P123, DOI 10.1002/dev.10165
   Bales KL, 2003, HORM BEHAV, V44, P178, DOI 10.1016/S0018-506X(03)00154-5
   Bales KL, 2004, HORM BEHAV, V45, P354, DOI 10.1016/j.yhbeh.2004.01.004
   Bales KL, 2005, AM J PRIMATOL, V66, P73
   Bales KL, 2007, NEUROSCIENCE, V144, P38, DOI 10.1016/j.neuroscience.2006.09.009
   Bales KL, 2003, BEHAV NEUROSCI, V117, P854, DOI 10.1037/0735-7044.117.4.854
   Bales KL, 2012, HORM BEHAV, V61, P313, DOI 10.1016/j.yhbeh.2011.12.013
   Bales KL, 2007, HORM BEHAV, V52, P274, DOI 10.1016/j.yhbeh.2007.05.004
   Bartz JA, 2011, TRENDS COGN SCI, V15, P301, DOI 10.1016/j.tics.2011.05.002
   Bartz JA, 2010, P NATL ACAD SCI USA, V107, P21371, DOI 10.1073/pnas.1012669107
   Baumgartner T, 2008, NEURON, V58, P639, DOI 10.1016/j.neuron.2008.04.009
   Beehner JC, 2005, ANIM BEHAV, V69, P1211, DOI 10.1016/j.anbehav.2004.08.014
   Benenson JF, 1998, HUM NATURE-INT BIOS, V9, P369, DOI 10.1007/s12110-998-1015-0
   Benenson JF, 2003, CHILD DEV, V74, P1123, DOI 10.1111/1467-8624.00596
   Benenson JF, 2004, EVOL HUM BEHAV, V25, P258, DOI 10.1016/j.evolhumbehav.2004.05.002
   BERNSTEIN IS, 1991, AM J PRIMATOL, V24, P29, DOI 10.1002/ajp.1350240104
   Boccia ML, 1997, PHYSIOL BEHAV, V61, P191, DOI 10.1016/S0031-9384(96)00370-8
   Bosch OJ, 2012, HORM BEHAV, V61, P293, DOI 10.1016/j.yhbeh.2011.11.002
   Buchheim A, 2009, PSYCHONEUROENDOCRINO, V34, P1417, DOI 10.1016/j.psyneuen.2009.04.002
   BUKOWSKI WM, 1994, J SOC PERS RELAT, V11, P471, DOI 10.1177/0265407594113011
   Capitanio JP, 2008, LANCET, V371, P1126, DOI 10.1016/S0140-6736(08)60489-4
   CAPITANIO JP, 1985, AM J PRIMATOL, V8, P53, DOI 10.1002/ajp.1350080106
   CARTER CS, 1995, NEUROSCI BIOBEHAV R, V19, P303
   Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025
   Carter CS, 2003, PHYSIOL BEHAV, V79, P383, DOI 10.1016/S0031-9384(03)00151-3
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Cheng SY, 2008, NEUROSCIENCE, V156, P247, DOI 10.1016/j.neuroscience.2008.07.048
   Cheng SY, 2009, PHYSIOL BEHAV, V98, P242, DOI 10.1016/j.physbeh.2009.04.019
   Cho MM, 1999, BEHAV NEUROSCI, V113, P1071, DOI 10.1037/0735-7044.113.5.1071
   COHEN S, 1985, PSYCHOL BULL, V98, P310, DOI 10.1037//0033-2909.98.2.310
   Coiro V, 2010, REGUL PEPTIDES, V162, P1, DOI 10.1016/j.regpep.2010.03.007
   CONVERTINO VA, 1981, J APPL PHYSIOL, V50, P123
   Crockford C, 2013, P ROY SOC B-BIOL SCI, V280, DOI 10.1098/rspb.2012.2765
   Crockford C, 2008, HORM BEHAV, V53, P254, DOI 10.1016/j.yhbeh.2007.10.007
   Cushing BS, 2003, J NEUROENDOCRINOL, V15, P1021, DOI 10.1046/j.1365-2826.2003.01097.x
   Dadds MR, 2014, J AUTISM DEV DISORD, V44, P521, DOI 10.1007/s10803-013-1899-3
   DATTA S, 1988, ANIM BEHAV, V36, P754, DOI 10.1016/S0003-3472(88)80159-3
   de Guzman MRT, 2004, SEX ROLES, V51, P217, DOI 10.1023/B:SERS.0000037765.77313.c4
   DeVries GJ, 1997, ANN NY ACAD SCI, V807, P273
   DEWAAL FBM, 1985, AM J PRIMATOL, V9, P73, DOI 10.1002/ajp.1350090202
   Dharmadhikari A, 1997, ANN NY ACAD SCI, V807, P610, DOI 10.1111/j.1749-6632.1997.tb51982.x
   Ebner NC, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00487
   ELSAYED MS, 1990, J SPORT MED PHYS FIT, V30, P420
   Erath SA, 2010, J APPL DEV PSYCHOL, V31, P15, DOI 10.1016/j.appdev.2009.05.005
   Feldman R, 2010, HORM BEHAV, V58, P669, DOI 10.1016/j.yhbeh.2010.06.005
   Feldman R, 2013, NEUROPSYCHOPHARMACOL, V38, P1154, DOI 10.1038/npp.2013.22
   Feldman R, 2010, PSYCHONEUROENDOCRINO, V35, P1133, DOI 10.1016/j.psyneuen.2010.01.013
   Feldman R, 2012, HORM BEHAV, V61, P380, DOI 10.1016/j.yhbeh.2012.01.008
   FERRARI R, 1991, CARDIOSCIENCE, V2, P131
   Frankel F, 2011, BRAIN RES, V1380, P240, DOI 10.1016/j.brainres.2010.09.047
   Frankel FD, 2011, J CHILD PSYCHOL PSYC, V52, P571, DOI 10.1111/j.1469-7610.2010.02318.x
   FULLERTON CS, 1994, J YOUTH ADOLESCENCE, V23, P43, DOI 10.1007/BF01537141
   GERSHMAN ES, 1983, MERRILL PALMER QUART, V29, P169
   Gimpl G, 2001, PHYSIOL REV, V81, P629
   Goodson JL, 2013, PSYCHONEUROENDOCRINO, V38, P465, DOI 10.1016/j.psyneuen.2012.12.005
   Gordon I, 2008, PSYCHOPHYSIOLOGY, V45, P349, DOI 10.1111/j.1469-8986.2008.00649.x
   Gouin JP, 2012, BIOL PSYCHOL, V91, P270, DOI 10.1016/j.biopsycho.2012.07.003
   Green LA, 2001, BIOL PSYCHIAT, V50, P609, DOI 10.1016/S0006-3223(01)01139-8
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Gregory SG, 2013, JAMA PEDIATR, V167, P959, DOI 10.1001/jamapediatrics.2013.2904
   Grippo AJ, 2009, PSYCHONEUROENDOCRINO, V34, P1542, DOI 10.1016/j.psyneuen.2009.05.017
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P1220, DOI 10.1016/j.biopsych.2010.03.014
   GUST DA, 1994, PHYSIOL BEHAV, V55, P681, DOI 10.1016/0031-9384(94)90044-2
   Hardy CL, 2002, J EARLY ADOLESCENCE, V22, P117, DOI 10.1177/0272431602022002001
   HAUDE RH, 1976, ANIM LEARN BEHAV, V4, P163, DOI 10.3758/BF03214028
   Heinrichs M, 2003, BIOL PSYCHIAT, V54, P1389, DOI 10.1016/S0006-3223(03)00465-7
   HIGLEY JD, 1992, DEV PSYCHOL, V28, P1163, DOI 10.1037/0012-1649.28.6.1163
   HINDE RA, 1967, ANIM BEHAV, V15, P169, DOI 10.1016/S0003-3472(67)80029-0
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1126/science.3399889
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Jarcho MR, 2011, GENES BRAIN BEHAV, V10, P375, DOI 10.1111/j.1601-183X.2010.00677.x
   Joffe TH, 1997, J HUM EVOL, V32, P593, DOI 10.1006/jhev.1997.0140
   Kagerbauer SM, 2013, J NEUROENDOCRINOL, V25, P668, DOI 10.1111/jne.12038
   Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
   Kenkel WM, 2012, J NEUROENDOCRINOL, V24, P874, DOI 10.1111/j.1365-2826.2012.02301.x
   Keri S, 2011, PHYSIOL BEHAV, V102, P221, DOI 10.1016/j.physbeh.2010.11.011
   KON IS, 1978, J MARRIAGE FAM, V40, P143, DOI 10.2307/350615
   Kramer Kristin M., 2002, Hormones and Behavior, V41, P476
   LADD GW, 1990, CHILD DEV, V61, P1081, DOI 10.1111/j.1467-8624.1990.tb02843.x
   Landgraf R, 2004, FRONT NEUROENDOCRIN, V25, P150, DOI 10.1016/j.yfrne.2004.05.001
   Lim MM, 2004, NEUROSCIENCE, V125, P35, DOI 10.1016/j.neuroscience.2003.12.008
   Lindburg D. G., 1971, PRIMATE BEHAV DEV FI, P1
   Mason WA, 1998, PSYCHONEUROENDOCRINO, V23, P765
   Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
   Miller M, 2013, AUTISM RES, V6, P91, DOI 10.1002/aur.1270
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Nangle DW, 2003, J CLIN CHILD ADOLESC, V32, P546, DOI 10.1207/S15374424JCCP3204_7
   Nelson EE, 2009, NEUROPSYCHOPHARMACOL, V34, P90, DOI 10.1038/npp.2008.150
   Norman GJ, 2011, BIOL PSYCHOL, V86, P174, DOI 10.1016/j.biopsycho.2010.11.006
   Olff M, 2013, PSYCHONEUROENDOCRINO, V38, P1883, DOI 10.1016/j.psyneuen.2013.06.019
   PEDERSEN CA, 1979, P NATL ACAD SCI USA, V76, P6661, DOI 10.1073/pnas.76.12.6661
   POIRIER FE, 1974, AM ZOOL, V14, P275
   Reza AM, 2011, AFR J BIOTECHNOL, V10, P12984
   Rilling JK, 2012, PSYCHONEUROENDOCRINO, V37, P447, DOI 10.1016/j.psyneuen.2011.07.013
   Rowley E, 2012, RES AUTISM SPECT DIS, V6, P1126, DOI 10.1016/j.rasd.2012.03.004
   Rubin KH, 2004, J EARLY ADOLESCENCE, V24, P326, DOI 10.1177/0272431604268530
   Scheele D, 2012, J NEUROSCI, V32, P16074, DOI 10.1523/JNEUROSCI.2755-12.2012
   Schneiderman I, 2012, PSYCHONEUROENDOCRINO, V37, P1277, DOI 10.1016/j.psyneuen.2011.12.021
   Silk JB, 2009, P ROY SOC B-BIOL SCI, V276, P3099, DOI 10.1098/rspb.2009.0681
   Silk JB, 2010, CURR BIOL, V20, P1359, DOI 10.1016/j.cub.2010.05.067
   Silk JB, 2003, SCIENCE, V302, P1231, DOI 10.1126/science.1088580
   Silk JB, 2002, BEHAVIOUR, V139, P421, DOI 10.1163/156853902760102735
   Smuts B. B., 1985, SEX FRIENDSHIP BABOO
   Sofroniew M. V., 1985, HDB CHEM NEUROANAT 1, V4, P93
   Spinka M, 2001, Q REV BIOL, V76, P141, DOI 10.1086/393866
   Strathearn L, 2012, HORM BEHAV, V61, P429, DOI 10.1016/j.yhbeh.2012.01.014
   Stribley JM, 1999, P NATL ACAD SCI USA, V96, P12601, DOI 10.1073/pnas.96.22.12601
   Suomi SJ, 2005, HUM DEV, V48, P67, DOI 10.1159/000083216
   Tachibana M, 2013, J CHILD ADOL PSYCHOP, V23, P123, DOI 10.1089/cap.2012.0048
   Taylor SE, 2010, PSYCHOL SCI, V21, P3, DOI 10.1177/0956797609356507
   Taylor SE, 2006, PSYCHOSOM MED, V68, P238, DOI 10.1097/01.psy.0000203242.95990.74
   Thompson R, 2004, PSYCHONEUROENDOCRINO, V29, P35, DOI 10.1016/S0306-4530(02)00133-6
   Thompson RR, 2006, P NATL ACAD SCI USA, V103, P7889, DOI 10.1073/pnas.0600406103
   Thorsteinsson EB, 1999, PSYCHOL HEALTH, V14, P869, DOI 10.1080/08870449908407353
   Uchino BN, 1996, PSYCHOL BULL, V119, P488, DOI 10.1037/0033-2909.119.3.488
   Veenema AH, 2012, HORM BEHAV, V61, P304, DOI 10.1016/j.yhbeh.2011.12.002
   Veenema AH, 2009, PSYCHONEUROENDOCRINO, V34, P463, DOI 10.1016/j.psyneuen.2008.10.017
   Viviani D, 2011, SCIENCE, V333, P104, DOI 10.1126/science.1201043
   Waldrip AM, 2008, SOC DEV, V17, P832, DOI 10.1111/j.1467-9507.2008.00476.x
   Wang JL, 2012, J COMP PHYSIOL A, V198, P787, DOI 10.1007/s00359-012-0748-8
   Wang ZX, 1998, PROG BRAIN RES, V119, P483
   Weinstein T. A. R., 2008, HDB PERSONALITY THEO, P328
   Weinstein TAR, 2005, BEHAV BRAIN SCI, V28, P366
   Weinstein TAR, 2008, ANIM BEHAV, V76, P455, DOI 10.1016/j.anbehav.2008.01.024
   Weinstein TAR, 2012, J COMP PSYCHOL, V126, P97, DOI 10.1037/a0025607
   Weiss A, 2011, J COMP PSYCHOL, V125, P72, DOI 10.1037/a0021187
   WINSLOW JT, 1993, NATURE, V365, P545, DOI 10.1038/365545a0
   WITT DM, 1991, J NEUROENDOCRINOL, V3, P155, DOI 10.1111/j.1365-2826.1991.tb00258.x
   WITTERT GA, 1991, CLIN ENDOCRINOL, V35, P311, DOI 10.1111/j.1365-2265.1991.tb03542.x
   Wittig RM, 2008, HORM BEHAV, V54, P170, DOI 10.1016/j.yhbeh.2008.02.009
   Zak PJ, 2005, HORM BEHAV, V48, P522, DOI 10.1016/j.yhbeh.2005.07.009
   Zak PJ, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001128
   Zhong SF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051095
   Zingg H. H., 2002, HORMONES BRAIN BEHAV, P779
NR 143
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD AUG 28
PY 2014
VL 8
AR 295
DI 10.3389/fnbeh.2014.00295
PG 13
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AN9DY
UT WOS:000340907400001
PM 25221489
ER

PT J
AU Wilkins, RW
   Hodges, DA
   Laurienti, PJ
   Steen, M
   Burdette, JH
AF Wilkins, R. W.
   Hodges, D. A.
   Laurienti, P. J.
   Steen, M.
   Burdette, J. H.
TI Network Science and the Effects of Music Preference on Functional Brain
   Connectivity: From Beethoven to Eminem
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DEFAULT MODE NETWORK; SMALL-WORLD; EMOTIONAL RESPONSES; MEMORY; AUTISM;
   CONSCIOUSNESS; PERSONALITY; CORRELATE; PLEASANT; DISEASE
AB Most people choose to listen to music that they prefer or 'like' such as classical, country or rock. Previous research has focused on how different characteristics of music (i.e., classical versus country) affect the brain. Yet, when listening to preferred music-regardless of the type-people report they often experience personal thoughts and memories. To date, understanding how this occurs in the brain has remained elusive. Using network science methods, we evaluated differences in functional brain connectivity when individuals listened to complete songs. We show that a circuit important for internally-focused thoughts, known as the default mode network, was most connected when listening to preferred music. We also show that listening to a favorite song alters the connectivity between auditory brain areas and the hippocampus, a region responsible for memory and social emotion consolidation. Given that musical preferences are uniquely individualized phenomena and that music can vary in acoustic complexity and the presence or absence of lyrics, the consistency of our results was unexpected. These findings may explain why comparable emotional and mental states can be experienced by people listening to music that differs as widely as Beethoven and Eminem. The neurobiological and neurorehabilitation implications of these results are discussed.
C1 [Wilkins, R. W.; Laurienti, P. J.; Steen, M.; Burdette, J. H.] Wake Forest Sch Med, Lab Complex Brain Networks, Winston Salem, NC 27157 USA.
   [Wilkins, R. W.] Univ N Carolina, Gateway MRI Ctr, Joint Sch Nanosci & Nanoengn, Neuroimaging Lab Complex Syst, Greensboro, NC 27401 USA.
   [Wilkins, R. W.; Hodges, D. A.] Univ N Carolina, Mus Res Inst, Greensboro, NC 27403 USA.
RP Wilkins, RW (reprint author), Wake Forest Sch Med, Lab Complex Brain Networks, Winston Salem, NC 27157 USA.
EM robinwwilkins@gmail.com
CR Alluri V, 2013, NEUROIMAGE, V83, P627, DOI 10.1016/j.neuroimage.2013.06.064
   Alluri V, 2012, NEUROIMAGE, V59, P3677, DOI 10.1016/j.neuroimage.2011.11.019
   Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
   Ball P, 2008, NATURE, V453, P160, DOI 10.1038/453160a
   Barrett FS, 2010, EMOTION, V10, P390, DOI 10.1037/a0019006
   Bassett DS, 2011, P NATL ACAD SCI USA, V108, P7641, DOI 10.1073/pnas.1018985108
   Bassett DS, 2011, TRENDS COGN SCI, V15, P200, DOI 10.1016/j.tics.2011.03.006
   Bassett DS, 2009, CURR OPIN NEUROL, V22, P340, DOI 10.1097/WCO.0b013e32832d93dd
   Bassett DS, 2006, NEUROSCIENTIST, V12, P512, DOI 10.1177/1073858406293182
   Blood AJ, 1999, NAT NEUROSCI, V2, P382, DOI 10.1038/7299
   Blood AJ, 2001, P NATL ACAD SCI USA, V98, P11818, DOI 10.1073/pnas.191355898
   Brattico E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00308
   Broyd SJ, 2009, NEUROSCI BIOBEHAV R, V33, P279, DOI 10.1016/j.neubiorev.2008.09.002
   Bullmore ET, 2009, NAT REV NEUROSCI, V10, P186, DOI 10.1038/nrn2575
   Burunat I, 2014, CORTEX, V57, P254, DOI 10.1016/j.cortex.2014.04.012
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   Cong F., J NEUROSCI METHODS, V223, P74
   Cross I, 2003, ANN NY ACAD SCI, V999, P106, DOI 10.1196/annals.1284.010
   Damasio Antonio, 1999, FEELING WHAT HAPPENS
   Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
   Fransson P, 2008, NEUROIMAGE, V42, P1178, DOI 10.1016/j.neuroimage.2008.05.059
   Gabrielsson A, 2011, STRONG EXPERIENCES M
   Gusnard DA, 2001, P NATL ACAD SCI USA, V98, P4259, DOI 10.1073/pnas.071043098
   Hayasaka S, 2010, NEUROIMAGE, V50, P499, DOI 10.1016/j.neuroimage.2009.12.051
   Immordino-Yang M. H., 2011, HUM BRAIN MAPP
   Immordino-Yang MH, 2011, EDUC PHILOS THEORY, V43, P98, DOI 10.1111/j.1469-5812.2010.00713.x
   Immordino-Yang MH, 2012, PERSPECT PSYCHOL SCI, V7, P352, DOI 10.1177/1745691612447308
   Jackendoff R, 2006, COGNITION, V100, P33, DOI 10.1016/j.cognition.2005.11.005
   Janata P, 2009, CEREB CORTEX, V19, P2579, DOI 10.1093/cercor/bhp008
   Jin MW, 2012, MAGN RESON IMAGING, V30, P48, DOI 10.1016/j.mri.2011.07.007
   Johnson MK, 2006, SOC COGN AFFECT NEUR, V1, P56, DOI 10.1093/scan/nsl004
   Juslin P. N., 2008, BEHAV BRAIN SCI, V31, P575, DOI [DOI 10.1017/50140525X08005293, 10.1017/50140525X08005293]
   Juslin P.N., 2001, MUSIC EMOTION THEORY
   Juslin PN, 2008, BEHAV BRAIN SCI, V31, P559, DOI 10.1017/S0140525X08005293
   Latora V, 2001, PHYS REV LETT, V87, DOI 10.1103/PhysRevLett.87.198701
   Laurienti PJ, 2011, PHYSICA A, V390, P3608, DOI 10.1016/j.physa.2011.05.011
   Masataka N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00694
   Menon V, 2005, NEUROIMAGE, V28, P175, DOI 10.1016/j.neuroimage.2005.05.053
   Molnar-Szakacs I, 2012, ANN NY ACAD SCI, V1252, P318, DOI 10.1111/j.1749-6632.2012.06465.x
   Moussa MN, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00083
   Newman MEJ, 2004, PHYS REV E, V69, DOI 10.1103/PhysRevE.69.026113
   Owen AM, 2009, PROG BRAIN RES, V177, P399, DOI 10.1016/S0079-6123(09)17728-2
   Perlovsky L, 2010, PHYS LIFE REV, V7, P2, DOI 10.1016/j.plrev.2009.11.001
   Raichle Marcus E, 2010, Trends Cogn Sci, V14, P180, DOI 10.1016/j.tics.2010.01.008
   Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
   Rentfrow PJ, 2003, J PERS SOC PSYCHOL, V84, P1236, DOI 10.1037/0022-3514.84.6.1236
   Rentfrow PJ, 2006, PSYCHOL SCI, V17, P236, DOI 10.1111/j.1467-9280.2006.01691.x
   Ruan JH, 2008, PHYS REV E, V77, DOI 10.1103/PhysRevE.77.016104
   Rubinov M, 2010, NEUROIMAGE, V52, P1059, DOI 10.1016/j.neuroimage.2009.10.003
   Salimpoor VN, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007487
   Schlaug G, 2011, NEUROPSYCHOL REV, V21, P288, DOI 10.1007/s11065-011-9181-y
   Simmons-Stern NR, 2010, NEUROPSYCHOLOGIA, V48, P3164, DOI 10.1016/j.neuropsychologia.2010.04.033
   Soto D, 2009, P NATL ACAD SCI USA, V106, P6011, DOI 10.1073/pnas.0811681106
   Spreng RN, 2010, J COGNITIVE NEUROSCI, V22, P1112, DOI 10.1162/jocn.2009.21282
   Steen M, 2011, PHYS REV E, V84, DOI 10.1103/PhysRevE.84.016111
   Thaut MH, 2009, ANN NY ACAD SCI, V1169, P406, DOI 10.1111/j.1749-6632.2009.04585.x
   Thaut MH, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002312
   Toiviainen P, 2014, NEUROIMAGE, V88, P170, DOI 10.1016/j.neuroimage.2013.11.017
   van den Heuvel MP, 2008, NEUROIMAGE, V43, P528, DOI 10.1016/j.neuroimage.2008.08.010
   van den Heuvel MP, 2009, J NEUROSCI, V29, P7619, DOI 10.1523/JNEUROSCI.1443-09.2009
   Vanhaudenhuyse A, 2010, BRAIN, V133, P161, DOI 10.1093/brain/awp313
   Wilkins R. W., 2012, LEONARDO, V45
   Zatorre RJ, 2003, ANN NY ACAD SCI, V999, P4, DOI 10.1196/annals.1284.001
NR 63
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 28
PY 2014
VL 4
AR 6130
DI 10.1038/srep06130
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AN9NZ
UT WOS:000340935000001
PM 25167363
ER

PT J
AU Kashihara, K
AF Kashihara, Koji
TI A brain-computer interface for potential non-verbal facial communication
   based on EEG signals related to specific emotions
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE neutral faces; source localization; aversive conditioning; face
   recognition; electroencephalogram; brain computer interfaces
ID AMYOTROPHIC-LATERAL-SCLEROSIS; HUMAN NEURAL SYSTEM; FACE PERCEPTION;
   RECOGNITION; AMYGDALA; CORTEX; PROSOPAGNOSIA; EXPRESSIONS; PERFORMANCE;
   SYNCHRONY
AB Unlike assistive technology for verbal communication, the brain-machine or brain-computer interface (BMI/BCI) has not been established as a non-verbal communication tool for amyotrophic lateral sclerosis (ALS) patients. Face-to-face communication enables access to rich emotional information, but individuals suffering from neurological disorders, such as ALS and autism, may not express their emotions or communicate their negative feelings. Although emotions may be inferred by looking at facial expressions, emotional prediction for neutral faces necessitates advanced judgment. The process that underlies brain neuronal responses to neutral faces and causes emotional changes remains unknown. To address this problem, therefore, this study attempted to decode conditioned emotional reactions to neutral face stimuli. This direction was motivated by the assumption that if electroencephalogram (EEG) signals can be used to detect patients' emotional responses to specific inexpressive faces, the results could be incorporated into the design and development of BMI/BCI-based non-verbal communication tools. To these ends, this study investigated how a neutral face associated with a negative emotion modulates rapid central responses in face processing and then identified cortical activities. The conditioned neutral face-triggered event-related potentials that originated from the posterior temporal lobe statistically significantly changed during late face processing (600-700 ms) after stimulus, rather than in early face processing activities, such as P1 and N170 responses. Source localization revealed that the conditioned neutral faces increased activity in the right fusiform gyrus (FG). This study also developed an efficient method for detecting implicit negative emotional responses to specific faces by using EEG signals. A classification method based on a support vector machine enables the easy classification of neutral faces that trigger specific individual emotions. In accordance with this classification, a face on a computer morphs into a sad or displeased countenance. The proposed method could be incorporated as a part of non-verbal communication tools to enable emotional expression.
C1 Univ Tokushima, Inst Technol & Sci, Tokushima 7708506, Japan.
RP Kashihara, K (reprint author), Univ Tokushima, Inst Technol & Sci, 2-1 Minamijyousanjima, Tokushima 7708506, Japan.
EM kashihara.koji@tokushima-u.ac.jp
FU Japan Society for the Promotion of Science (KAKENHI) [25330171]
FX This study was partially funded by a Grant-in-Aid for Scientific
   Research (C) from Japan Society for the Promotion of Science (KAKENHI,
   25330171). The author would like to thank Nagoya University and JST for
   providing assistance during the EEG experiment.
CR Barton JJS, 2002, NEUROLOGY, V58, P71
   Batty M, 2003, COGNITIVE BRAIN RES, V17, P613, DOI 10.1016/S0926-6410(03)00174-5
   Bay H, 2008, COMPUT VIS IMAGE UND, V110, P346, DOI 10.1016/j.cviu.2007.09.014
   Bentin S, 1996, J COGNITIVE NEUROSCI, V8, P551, DOI 10.1162/jocn.1996.8.6.551
   Buchel C, 1998, NEURON, V20, P947, DOI 10.1016/S0896-6273(00)80476-6
   Caharel S, 2002, INT J NEUROSCI, V112, P1499, DOI 10.1080/00207450290158368
   CORTES C, 1995, MACH LEARN, V20, P273, DOI 10.1023/A:1022627411411
   CRISTIANINI N., 2000, INTRO SUPPORT VECTOR, DOI [10.1017/CBO9780511801389, DOI 10.1017/CBO9780511801389]
   Cruikshank SJ, 2008, NATURE, V454, P839, DOI 10.1038/454839a
   Csurka G., 2004, P ECCV WORKSH STAT L, P1
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Duda R. O., 2001, PATTERN CLASSIFICATI
   Eimer M, 2000, NEUROREPORT, V11, P2319, DOI 10.1097/00001756-200007140-00050
   Ferree TC, 2001, CLIN NEUROPHYSIOL, V112, P536, DOI 10.1016/S1388-2457(00)00533-2
   Ganis G, 2008, NEUROIMAGE, V42, P1714, DOI 10.1016/j.neuroimage.2008.07.004
   George N, 1999, NAT NEUROSCI, V2, P574, DOI 10.1038/9230
   Gramfort A, 2010, IEEE T BIO-MED ENG, V57, P1051, DOI 10.1109/TBME.2009.2037139
   Grave de Peralta Menendez R., 2009, COMPUT INTEL NEUROSC, V2009, DOI [10.1155/2009/659247, DOI 10.1155/2009/659247]
   Guo J, 2010, IEEE T NEUR SYS REH, V18, P230, DOI 10.1109/TNSRE.2010.2047604
   Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
   Hoffman EA, 2000, NAT NEUROSCI, V3, P80, DOI 10.1038/71152
   Hsu WY, 2009, J NEUROSCI METH, V176, P310, DOI 10.1016/j.jneumeth.2008.09.014
   Iversen IH, 2008, CLIN NEUROPHYSIOL, V119, P2214, DOI 10.1016/j.clinph.2008.07.001
   KASHIHARA K, 2011, P 2011 IEEE INT C SY, P25, DOI DOI 10.1109/ICSMC.2011.6083637
   Kashihara K, 2009, ANN BIOMED ENG, V37, P112, DOI 10.1007/s10439-008-9599-4
   Keltner D., 2000, HDB EMOTIONS, P236
   Kleinhans NM, 2007, NEUROREPORT, V18, P987, DOI 10.1097/WNR.0b013e328165d189
   Knight DC, 2009, NEUROIMAGE, V45, P208, DOI 10.1016/j.neuroimage.2008.11.015
   Lebedev MA, 2006, TRENDS NEUROSCI, V29, P536, DOI 10.1016/j.tins.2006.07.004
   Leppanen JM, 2009, NAT REV NEUROSCI, V10, P37, DOI 10.1038/nrn2554
   Leuthardt Eric C, 2004, J Neural Eng, V1, P63, DOI 10.1088/1741-2560/1/2/001
   Lotte F, 2007, J NEURAL ENG, V4, pR1, DOI 10.1088/1741-2560/4/R01
   Mak JN, 2011, J NEURAL ENG, V8, DOI 10.1088/1741-2560/8/2/025003
   Mak JN, 2012, J NEURAL ENG, V9, DOI 10.1088/1741-2560/9/2/026014
   Menendez RGD, 2000, BRAIN TOPOGR, V13, P97
   Morris JS, 2001, NEUROIMAGE, V13, P1044, DOI 10.1006/nimg.2000.0721
   Morris JS, 1998, NATURE, V393, P467, DOI 10.1038/30976
   Nesse R. M., 2005, PSYCHOL REV, V11, P12
   Nichols TE, 2002, HUM BRAIN MAPP, V15, P1, DOI 10.1002/hbm.1058
   Nijboer F., 2009, AFF COMP INT INT WOR, P1, DOI [DOI 10.1109/ACII.2009.5349479, 10.1109/ACII.2009.5349479]
   Pascual-Marqui RD, 2002, METHOD FIND EXP CLIN, V24, P5
   Pegna AJ, 2008, INT J PSYCHOPHYSIOL, V70, P127, DOI 10.1016/j.ijpsycho.2008.08.007
   Piccione F, 2006, CLIN NEUROPHYSIOL, V117, P531, DOI 10.1016/j.clinph.2005.07.024
   Poulet JFA, 2008, NATURE, V454, P881, DOI 10.1038/nature07150
   Pourtois G, 2004, CEREB CORTEX, V14, P619, DOI 10.1093/cercor/bhh023
   Rossion B, 1999, CLIN NEUROPHYSIOL, V110, P449, DOI 10.1016/S1388-2457(98)00037-6
   Scharmuller W, 2011, BRAIN RES, V1397, P10, DOI 10.1016/j.brainres.2011.04.018
   Schweinberger SR, 2002, COGNITIVE BRAIN RES, V14, P398, DOI 10.1016/S0926-6410(02)00142-8
   SERGENT J, 1992, CEREB CORTEX, V2, P375, DOI 10.1093/cercor/2.5.375
   TallonBaudry C, 1996, J NEUROSCI, V16, P4240
   Tanaka JW, 2001, PSYCHOL SCI, V12, P43, DOI 10.1111/1467-9280.00308
   Taylor MJ, 2009, HUM BRAIN MAPP, V30, P2008, DOI 10.1002/hbm.20646
   Todorov A, 2007, NEUROPSYCHOLOGIA, V45, P163, DOI 10.1016/j.neuropsychologia.2006.04.018
   Tomik B, 2010, AMYOTROPH LATERAL SC, V11, P4, DOI 10.3109/17482960802379004
   Utama NP, 2009, NEUROSCI RES, V64, P30, DOI 10.1016/j.neures.2009.01.009
   Zander TO, 2010, HUM-COMPUT INT-SPRIN, P181, DOI 10.1007/978-1-84996-272-8_11
NR 56
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD AUG 26
PY 2014
VL 8
AR 244
DI 10.3389/fnins.2014.00244
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA AW8LA
UT WOS:000346512100001
PM 25206321
ER

PT J
AU Rossignol, R
   Ranchon-Cole, I
   Paris, A
   Herzine, A
   Perche, A
   Laurenceau, D
   Bertrand, P
   Cercy, C
   Pichon, J
   Mortaud, S
   Briault, S
   Menuet, A
   Perche, O
AF Rossignol, Rafaelle
   Ranchon-Cole, Isabelle
   Paris, Arnaud
   Herzine, Ameziane
   Perche, Astrid
   Laurenceau, David
   Bertrand, Pauline
   Cercy, Christine
   Pichon, Jacques
   Mortaud, Stephane
   Briault, Sylvain
   Menuet, Arnaud
   Perche, Olivier
TI Visual Sensorial Impairments in Neurodevelopmental Disorders: Evidence
   for a Retinal Phenotype in Fragile X Syndrome
SO PLOS ONE
LA English
DT Article
ID FMR1 KNOCKOUT MICE; MENTAL-RETARDATION PROTEIN; SYNDROME MOUSE MODEL;
   RECEPTOR-DEPENDENT TRANSLATION; SYNAPTIC DEVELOPMENT;
   SOCIAL-INTERACTION; RHODOPSIN CONTENT; DENDRITIC SPINES; AUTISM; PSD-95
AB Visual sensory impairments are common in Mental Deficiency (MD) and Autism Spectrum Disorder (ASD). These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth/guidance and dendrite spine immaturity of neurons. However, visual perception had not been addressed, although the retina is part of the central nervous system with a common embryonic origin. Therefore, we investigated retinal perception, the first event of vision, in a murine model of MD with autistic features. We document that retinal function is altered in Fmr1 KO mice, a model of human Fragile X Syndrome. Indeed, In Fmr1 KO mice had a lower retinal function characterized by a decreased photoreceptors neuron response, due to a 40% decrease in Rhodopsin content and to Rod Outer Segment destabilization. In addition, we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post-synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity. Thus, for the first time, we demonstrated that retinal perception is altered in a murine model of MD with autistic features and that there are strong similarities between cerebral and retinal cellular and molecular defects. Our results suggest that both visual perception and integration must be taken into account in assessing visual sensory impairments in MD and ASD.
C1 [Rossignol, Rafaelle; Paris, Arnaud; Herzine, Ameziane; Pichon, Jacques; Mortaud, Stephane; Briault, Sylvain; Menuet, Arnaud; Perche, Olivier] CNRS, UMR7355, F-45071 Orleans, France.
   [Rossignol, Rafaelle; Paris, Arnaud; Herzine, Ameziane; Pichon, Jacques; Mortaud, Stephane; Briault, Sylvain; Menuet, Arnaud; Perche, Olivier] Univ Orleans, Orleans, France.
   [Perche, Astrid; Laurenceau, David; Briault, Sylvain; Perche, Olivier] Reg Hosp, Dept Genet, Orleans, France.
   [Ranchon-Cole, Isabelle; Bertrand, Pauline; Cercy, Christine] Univ Clermont 1, Lab Sensorial Biophys, Clermont Ferrand, France.
RP Perche, O (reprint author), CNRS, UMR7355, F-45071 Orleans, France.
EM operche@cnrs-orleans.fr
FU CNRS; Regional Hospital of Orleans; University of Orleans; FEDER
   [35106]; FRAXA Research Foundation
FX Research was supported by CNRS, Regional Hospital of Orleans, University
   of Orleans, FEDER 35106, and FRAXA Research Foundation. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Baranek GT, 2002, AM J OCCUP THER, V56, P538
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Battaglia A, 2011, ARCH ITAL BIOL, V149, P193, DOI 10.4449/aib.v149i2.1362
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Berman RF, 2012, EPILEPSIA, V53, P150, DOI 10.1111/j.1528-1167.2012.03486.x
   BIERSDORFF KK, 1994, AM J MENT RETARD, V98, P619
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Bonetti C, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015211
   Braun K, 2000, CEREB CORTEX, V10, P1045, DOI 10.1093/cercor/10.10.1045
   Chen PC, 2011, J NEUROSCI, V31, P17505, DOI 10.1523/JNEUROSCI.2922-11.2011
   Cline H, 2005, CURR BIOL, V15, pR203, DOI 10.1016/j.cub.2005.03.010
   Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
   BAKKER CE, 1994, CELL, V78, P23
   Bernardet M, 2006, THESCIENTIFICWORLDJO, V6, P1164, DOI 10.1100/tsw.2006.220
   Davidovic L, 2011, GENOME RES, V21, P2190, DOI 10.1101/gr.116764.110
   Dolen G, 2009, J NEURODEV DISORD, V1, P133, DOI 10.1007/s11689-009-9015-x
   Farzin F, 2011, BRAIN, V134, P3355, DOI 10.1093/brain/awr249
   FOX DA, 1989, EXP EYE RES, V48, P237, DOI 10.1016/S0014-4835(89)80073-9
   Frishman LJ, 2006, ORIGINS ELECTRORETIN, P139
   Fulton AB, 1999, INVEST OPHTH VIS SCI, V40, P1878
   Granit R, 1933, J PHYSIOL-LONDON, V77, P207
   HOFMANN KP, 1985, J BIOL CHEM, V260, P7990
   Irwin SA, 2002, AM J MED GENET, V111, P140, DOI 10.1002/ajmg.10500
   Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
   KANEKO A, 1979, ANNU REV NEUROSCI, V2, P169, DOI 10.1146/annurev.ne.02.030179.001125
   Klemmer P, 2011, J BIOL CHEM, V286, P25495, DOI 10.1074/jbc.M110.210260
   Kogan CS, 2004, BRAIN, V127, P591, DOI 10.1093/brain/awh069
   Krueger DD, 2011, P NATL ACAD SCI USA, V108, P2587, DOI 10.1073/pnas.1013855108
   LAMB TD, 1992, TRENDS NEUROSCI, V15, P291, DOI 10.1016/0166-2236(92)90079-N
   LAMB TD, 1992, J PHYSIOL-LONDON, V449, P719
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Lane NE, 2010, NEW ENGL J MED, V363, P1521, DOI 10.1056/NEJMoa0901510
   Lee ES, 2007, INVEST OPHTH VIS SCI, V48, P2868, DOI 10.1167/iovs.06-0035
   Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031
   Levenga J, 2011, NEUROBIOL LEARN MEM, V95, P467, DOI 10.1016/j.nlm.2011.02.009
   Liang Y, 2004, J BIOL CHEM, V279, P48189, DOI 10.1074/jbc.M408362200
   Liao LJ, 2008, P NATL ACAD SCI USA, V105, P15281, DOI 10.1073/pnas.0804678105
   McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293]
   Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706
   Mineur YS, 2006, BEHAV BRAIN RES, V168, P172, DOI 10.1016/j.bbr.2005.11.004
   Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x
   Muddashetty RS, 2007, J NEUROSCI, V27, P5338, DOI 10.1523/JNEUROSCI.0937-07.2007
   Nader R, 2004, CLIN J PAIN, V20, P88, DOI 10.1097/00002508-200403000-00005
   Nimchinsky EA, 2001, J NEUROSCI, V21, P5139
   PEI YF, 1970, ANAT REC, V168, P105, DOI 10.1002/ar.1091680109
   Penagarikano O, 2007, ANNU REV GENOM HUM G, V8, P109, DOI 10.1146/annurev.genom.8.080706.092249
   Perche O, 2007, INVEST OPHTH VIS SCI, V48, P2753, DOI 10.1167/iovs.06-1258
   Perche O, 2013, EUR J MED GENET, V56, P635, DOI 10.1016/j.ejmg.2013.07.007
   Perche O, 2009, EXP EYE RES, V89, P989, DOI 10.1016/j.exer.2009.08.012
   Pfeiffer BE, 2010, NEURON, V66, P191, DOI 10.1016/j.neuron.2010.03.017
   Price BA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049889
   Purves D., 2001, NEUROSCIENCE, V2nd
   Shi D, 2012, J NEUROCHEM, V123, P971, DOI 10.1111/jnc.12048
   Todd PK, 2003, P NATL ACAD SCI USA, V100, P14374, DOI 10.1073/pnas.2336265100
   Tsai NP, 2012, CELL, V151, P1581, DOI 10.1016/j.cell.2012.11.040
   Vanderklish PW, 2005, GENES BRAIN BEHAV, V4, P360, DOI 10.1111/j.1601-183X.2005.00134.x
   Volpe JJ, 2001, MENT RETARD DEV D R, V7, P56, DOI 10.1002/1098-2779(200102)7:1<56::AID-MRDD1008>3.0.CO;2-A
   Westmark CJ, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00057
   Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
   Zalfa F, 2007, NAT NEUROSCI, V10, P578, DOI 10.1038/nn1893
   Zhu ZW, 2011, NEUROPATHOLOGY, V31, P223, DOI 10.1111/j.1440-1789.2010.01165.x
   Zukin RS, 2009, FRONT NEURAL CIRCUIT, V3, DOI 10.3389/neuro.04.014.2009
NR 65
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 25
PY 2014
VL 9
IS 8
AR e105996
DI 10.1371/journal.pone.0105996
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AN9TR
UT WOS:000340952200103
PM 25153086
ER

PT J
AU Rahbar, MH
   Samms-Vaughan, M
   Dickerson, AS
   Loveland, KA
   Ardjomand-Hessabi, M
   Bressler, J
   Shakespeare-Pellington, S
   Grove, ML
   Pearson, DA
   Boerwinkle, E
AF Rahbar, Mohammad H.
   Samms-Vaughan, Maureen
   Dickerson, Aisha S.
   Loveland, Katherine A.
   Ardjomand-Hessabi, Manouchehr
   Bressler, Jan
   Shakespeare-Pellington, Sydonnie
   Grove, Megan L.
   Pearson, Deborah A.
   Boerwinkle, Eric
TI Blood manganese concentrations in Jamaican children with and without
   autism spectrum disorders
SO ENVIRONMENTAL HEALTH
LA English
DT Article
DE Manganese; Autism Spectrum Disorder; Neurodevelopment; Seafood;
   Vegetables; Jamaica
ID HEAVY-METAL CONTAMINATION; DRINKING-WATER; SEAFOOD CONSUMPTION;
   GENERAL-POPULATION; CHILDHOOD AUTISM; RISK-ASSESSMENT; EXPOSURE; AGE;
   BIOMARKERS; HAIR
AB Background: Manganese is an essential element for human health and development. Previous studies have shown neurotoxic effects in children exposed to higher levels of manganese. Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impairs social interaction and communication. Several studies have hypothesized that ASD is caused through environmental exposures during crucial stages in brain development. We investigated the possible association between blood manganese concentrations (BMC) and ASD. We also identified factors associated with BMC in typically developing (TD) Jamaican children.
   Methods: We used data from 109 ASD cases with their 1:1 age- and sex-matched TD controls to compare mean BMC in Jamaican children (2-8 years of age) with and without ASD. We administered a pre-tested questionnaire to assess demographic and socioeconomic information, medical history, and potential exposure to manganese. Finally, we collected 2 mL of whole blood from each child for analysis of manganese levels. Using General Linear Models (GLM), we assessed the association between BMC and ASD status. Furthermore, we used two independent sample t-tests to identify factors associated with BMC in TD children.
   Results: In univariable GLM analysis, we found no significant association between BMC and ASD, (10.9 mu g/L for cases vs. 10.5 mu g/L for controls; P = 0.29). In a multivariable GLM adjusting for paternal age, parental education, place of child's birth (Kingston parish), consumption of root vegetables, cabbage, saltwater fish, and cakes/buns, there was still no significant association between BMC and ASD status, (11.5 mu g/L for cases vs. 11.9 mu g/L for controls; P = 0.48). Our findings also indicated TD children who ate fresh water fish had a higher BMC than children who did not (11.0 mu g/L vs. 9.9 mu g/L; P = 0.03) as younger TD children (i.e., 2 <= age <= 4), (12.0 mu g/L vs. 10.2 mu g/L; P = 0.01).
   Conclusions: While these results cannot be used to assess early exposure at potentially more susceptible time period, our findings suggest that there is no significant association between manganese exposures and ASD case status in Jamaica. Our findings also indicate that BMC in Jamaican children resemble those of children in the developed world and are much lower than those in the developing countries.
C1 [Rahbar, Mohammad H.; Boerwinkle, Eric] Univ Texas Sch Publ Hlth Houston, Div Epidemiol Human Genet & Environm Sci EHGES, Houston, TX 77030 USA.
   [Rahbar, Mohammad H.] Univ Texas Med Sch Houston, Dept Internal Med, Div Clin & Translat Sci, Houston, TX 77030 USA.
   [Rahbar, Mohammad H.; Dickerson, Aisha S.; Ardjomand-Hessabi, Manouchehr] Univ Texas Hlth Sci Ctr Houston, CCTS, Houston, TX 77030 USA.
   [Samms-Vaughan, Maureen; Shakespeare-Pellington, Sydonnie] Univ W Indies, Dept Child & Adolescent Hlth, Kingston, Jamaica.
   [Loveland, Katherine A.; Pearson, Deborah A.] Univ Texas Med Sch Houston, Dept Psychiat & Behav Sci, Houston, TX 77054 USA.
   [Bressler, Jan; Grove, Megan L.; Boerwinkle, Eric] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA.
RP Rahbar, MH (reprint author), Univ Texas Sch Publ Hlth Houston, Div Epidemiol Human Genet & Environm Sci EHGES, Houston, TX 77030 USA.
EM Mohammad.H.Rahbar@uth.tmc.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD); National Institutes of Health Fogarty International
   Center (NIH-FIC) [R21HD057808]; National Institute of Environmental
   Health Sciences (NIEHS) [R01ES022165]; NIH Centers for Translational
   Science Award (NIH CTSA) [UL1 RR024148]; National Center for Research
   Resources (NCRR); National Center for Advancing Translational Sciences
   (NCATS) [UL1 TR000371]; Biostatistics/Epidemiology/Research Design
   (BERD) component of the Center for Clinical and Translational Sciences
   (CCTS)
FX This research is co-funded by the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (NICHD) and the National
   Institutes of Health Fogarty International Center (NIH-FIC) by a grant
   [R21HD057808] as well as National Institute of Environmental Health
   Sciences (NIEHS) by a grant [R01ES022165] awarded to University of Texas
   Health Science Center at Houston. We also acknowledge the support
   provided by the Biostatistics/Epidemiology/Research Design (BERD)
   component of the Center for Clinical and Translational Sciences (CCTS)
   for this project. CCTS is mainly funded by the NIH Centers for
   Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to
   University of Texas Health Science Center at Houston in 2006 by the
   National Center for Research Resources (NCRR) and its renewal (UL1
   TR000371) by the National Center for Advancing Translational Sciences
   (NCATS). The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the NICHD or the
   NIH-FIC or NIEHS or the NCRR or the NCATS.
CR Abdullah MM, 2012, J AUTISM DEV DISORD, V42, P929, DOI 10.1007/s10803-011-1318-6
   Adams JB, 2006, BIOL TRACE ELEM RES, V110, P193, DOI 10.1385/BTER:110:3:193
   Afridi HI, 2011, BIOL TRACE ELEM RES, V143, P103, DOI 10.1007/s12011-010-8851-6
   Agency for Toxic Substances and Disease Registry (ATSDR), 2012, 7439965 ATSDR CAS
   Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P213
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   [Anonymous], 2012, TOX PROF MANG
   Baldwin M, 1999, NEUROTOXICOLOGY, V20, P343
   Batterman S, 2011, SCI TOTAL ENVIRON, V409, P1058, DOI 10.1016/j.scitotenv.2010.12.017
   Bhang SY, 2013, ENVIRON RES, V126, P9, DOI 10.1016/j.envres.2013.05.006
   Blaurock-Busch Eleonor, 2012, Maedica (Buchar), V7, P38
   Blaurock-Busch Eleonor, 2011, Maedica (Buchar), V6, P247
   Bouchard M, 2007, ENVIRON HEALTH PERSP, V115, P122, DOI 10.1289/ehp.9504
   Bouchard MF, 2011, ENVIRON HEALTH PERSP, V119, P138, DOI 10.1289/ehp.1002321
   Boyes WK, 2010, J TOXICOL ENV HEAL A, V73, P159, DOI 10.1080/15287390903340419
   Burger J, 2009, ENVIRON RES, V109, P343, DOI 10.1016/j.envres.2008.12.002
   Burger J, 2005, ENVIRON RES, V99, P403, DOI 10.1016/j.envres.2005.02.001
   Centers for Disease Control and Prevention (CDC) National Center for Health Statistics (NCHS), 2013, NAT HLTH NUTR EX SUR
   CHAN AWK, 1992, METAB BRAIN DIS, V7, P21, DOI 10.1007/BF01000438
   COLLIPP PJ, 1983, ANN NUTR METAB, V27, P488, DOI 10.1159/000176724
   De Palma G, 2012, J AUTISM DEV DISORD, V42, P342, DOI 10.1007/s10803-011-1245-6
   Ebrahimzadeh MA, 2011, BIOL TRACE ELEM RES, V144, P804, DOI 10.1007/s12011-011-9095-9
   Environmental Protection Agency (EPA), 2007, MANG TOX EXP ASS CHI
   Ericson JE, 2007, NEUROTOXICOL TERATOL, V29, P181, DOI 10.1016/j.ntt.2006.09.020
   Finley JW, 1999, BIOFACTORS, V10, P15
   Fraser M, 2013, ENVIRON SCI POLLUT R, V20, P761, DOI 10.1007/s11356-012-1134-3
   Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
   Genuis SJ, 2009, ACTA PAEDIATR, V98, P1575, DOI 10.1111/j.1651-2227.2009.01495.x
   Geschwind DH, 2013, INT M AUT RES IMFAR
   Gillberg C, 2013, INT M AUT RES IMFAR
   Greger JL, 1999, NEUROTOXICOLOGY, V20, P205
   Gulson B, 2006, ENVIRON RES, V100, P100, DOI 10.1016/j.envres.2005.03.013
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Haynes EN, 2012, SCI TOTAL ENVIRON, V427, P19, DOI 10.1016/j.scitotenv.2012.03.037
   Henn BC, 2010, EPIDEMIOLOGY, V21, P433, DOI 10.1097/EDE.0b013e3181df8e52
   Henn BC, 2012, ENVIRON HEALTH PERSP, V120, P126, DOI 10.1289/ehp.1003300
   Hertz-Picciotto I, 2013, INT M AUT RES IMFAR
   Howe A, 2005, ENVIRON GEOCHEM HLTH, V27, P19, DOI 10.1007/s10653-004-5671-7
   Jory J, 2008, AM J BIOCH BIOTECHNO, V4, P101
   Khan K, 2012, NEUROTOXICOLOGY, V33, P91, DOI 10.1016/j.neuro.2011.12.002
   Khan K, 2011, ENVIRON HEALTH PERSP, V119, P1501, DOI 10.1289/ehp.1003397
   Kim Y, 2009, NEUROTOXICOLOGY, V30, P564, DOI 10.1016/j.neuro.2009.03.012
   Kumar B, 2013, J MAR BIOL OCEANOGR, V2
   Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
   Lalor GC, 1996, ENVIRON GEOCHEM HLTH, V18, P89, DOI 10.1007/BF01771284
   Landrigan PJ, 2012, ENVIRON HEALTH PERSP, V120, pA258, DOI 10.1289/ehp.1104285
   Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Menezes JA, 2011, ENVIRON RES, V111, P156, DOI 10.1016/j.envres.2010.09.006
   Mulligan A, 2009, IRISH J MED SCI, V178, P193, DOI 10.1007/s11845-008-0184-5
   Nduka JKC, 2008, THESCIENTIFICWORLDJO, V8, P941, DOI 10.1100/tsw.2008.129
   Palmer RF, 2010, PEDIATRICS, V126
   Pieniak Z, 2010, J HUM NUTR DIET, V23, P480, DOI 10.1111/j.1365-277X.2010.01045.x
   Rahbar MH, 2013, NEUROTOX RES, V23, P22, DOI 10.1007/s12640-012-9321-z
   Rahbar MH, 2012, SCI TOTAL ENVIRON, V433, P362, DOI 10.1016/j.scitotenv.2012.06.085
   Rahbar MH, 2012, J AUTISM DEV DISORD, V42, P1928, DOI 10.1007/s10803-011-1438-z
   Rahbar MH, 2014, RES AUTISM SPECT DIS, V8, P1134, DOI 10.1016/j.rasd.2014.06.002
   Roels HA, 2012, NEUROTOXICOLOGY, V33, P872, DOI 10.1016/j.neuro.2012.03.009
   Rollin H, 2005, ENVIRON RES, V97, P93, DOI 10.1016/j.envres.2004.05.003
   Roth JA, 2006, BIOL RES, V39, P45, DOI 10.4067/S0716-97602006000100006
   Rutter M., 2003, SOCIAL COMMUNICATION
   Santamaria AB, 2010, J TOXICOL ENV HEAL A, V73, P128, DOI 10.1080/15287390903337118
   Santos-Burgoa C, 2001, ENVIRON RES, V85, P90, DOI 10.1006/enrs.2000.4108
   SAS Institute, 2011, SAS 9 3
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Smargiassi A, 1999, NEUROTOXICOLOGY, V20, P401
   Spencer A, 1999, NUTRITION, V15, P731, DOI 10.1016/S0899-9007(99)00144-6
   St-Pierre A, 2001, INHAL TOXICOL, V13, P623, DOI 10.1080/089583701300164276
   Takser L, 2003, NEUROTOXICOLOGY, V24, P667, DOI 10.1016/S0161-813X(03)00058-5
   Tong I S, 2001, Ann Epidemiol, V11, P38
   Turan C, 2009, B ENVIRON CONTAM TOX, V82, P601, DOI 10.1007/s00128-008-9624-1
   Volk HE, 2013, JAMA PSYCHIAT, V70, P71, DOI 10.1001/jamapsychiatry.2013.266
   Volkmar FR, 2008, WORLD PSYCHIATRY, V7, P19
   Wasserman GA, 2011, NEUROTOXICOLOGY, V32, P450, DOI 10.1016/j.neuro.2011.03.009
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Wright RO, 2006, NEUROTOXICOLOGY, V27, P210, DOI 10.1016/j.neuro.2005.10.001
   Zheng W, 2011, NEUROTOXICOLOGY, V32, P1, DOI 10.1016/j.neuro.2010.10.002
   Zodape G V, 2011, International Journal of Environmental Sciences, V1
   Zoni S, 2007, AM J IND MED, V50, P812, DOI 10.1002/ajim.20518
NR 80
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD AUG 23
PY 2014
VL 13
AR 69
DI 10.1186/1476-069X-13-69
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AP4KA
UT WOS:000342044400001
PM 25149876
ER

PT J
AU Gazzellone, MJ
   Zhou, X
   Lionel, AC
   Uddin, M
   Thiruvahindrapuram, B
   Liang, S
   Sun, CH
   Wang, J
   Zou, MY
   Tammimies, K
   Walker, S
   Selvanayagam, T
   Wei, J
   Wang, ZZ
   Wu, LJ
   Scherer, SW
AF Gazzellone, Matthew J.
   Zhou, Xue
   Lionel, Anath C.
   Uddin, Mohammed
   Thiruvahindrapuram, Bhooma
   Liang, Shuang
   Sun, Caihong
   Wang, Jia
   Zou, Mingyang
   Tammimies, Kristiina
   Walker, Susan
   Selvanayagam, Thanuja
   Wei, John
   Wang, Zhuozhi
   Wu, Lijie
   Scherer, Stephen W.
TI Copy number variation in Han Chinese individuals with autism spectrum
   disorder
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder (ASD); Copy number variations (CNVs);
   Microarray diagnostic testing; Han Chinese
ID MILLER-DIEKER-SYNDROME; STRUCTURAL VARIATION; VARIANTS; GENES;
   IDENTIFICATION; MICRODELETIONS; PHENOTYPES; MUTATIONS; DISCOVERY;
   FAMILIES
AB Background: Autism spectrum disorders (ASDs) are a group of neurodevelopmental conditions with a demonstrated genetic etiology. Rare (<1% frequency) copy number variations (CNVs) account for a proportion of the genetic events involved, but the contribution of these events in non-European ASD populations has not been well studied. Here, we report on rare CNVs detected in a cohort of individuals with ASD of Han Chinese background.
   Methods: DNA samples were obtained from 104 ASD probands and their parents who were recruited from Harbin, China. Samples were genotyped on the Affymetrix CytoScan HD platform. Rare CNVs were identified by comparing data with 873 technology-matched controls from Ontario and 1,235 additional population controls of Han Chinese ethnicity.
   Results: Of the probands, 8.6% had at least 1 de novo CNV (overlapping the GIGYF2, SPRY1, 16p13.3, 16p11.2, 17p13.3-17p13.2, DMD, and NAP1L6 genes/loci). Rare inherited CNVs affected other plausible neurodevelopmental candidate genes including GRID2, LINGO2, and SLC39A12. A 24-kb duplication was also identified at YWHAE, a gene previously implicated in ASD and other developmental disorders. This duplication is observed at a similar frequency in cases and in population controls and is likely a benign Asian-specific copy number polymorphism.
   Conclusions: Our findings help define genomic features relevant to ASD in the Han Chinese and emphasize the importance of using ancestry-matched controls in medical genetic interpretations.
C1 [Gazzellone, Matthew J.; Zhou, Xue; Lionel, Anath C.; Uddin, Mohammed; Thiruvahindrapuram, Bhooma; Tammimies, Kristiina; Walker, Susan; Selvanayagam, Thanuja; Wei, John; Wang, Zhuozhi; Scherer, Stephen W.] Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Ctr Appl Genom, Toronto, ON M5G 0A4, Canada.
   [Gazzellone, Matthew J.; Zhou, Xue; Lionel, Anath C.; Uddin, Mohammed; Thiruvahindrapuram, Bhooma; Tammimies, Kristiina; Walker, Susan; Selvanayagam, Thanuja; Wei, John; Wang, Zhuozhi; Scherer, Stephen W.] Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Program Genet & Genome Biol, Toronto, ON M5G 0A4, Canada.
   [Gazzellone, Matthew J.; Lionel, Anath C.; Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada.
   [Gazzellone, Matthew J.; Lionel, Anath C.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON M5S 1A1, Canada.
   [Zhou, Xue; Liang, Shuang; Sun, Caihong; Wang, Jia; Zou, Mingyang; Wu, Lijie] Harbin Med Univ, Dept Childrens & Adolescent Hlth, Coll Publ Hlth, Harbin 150086, Heilongjiang, Peoples R China.
   [Zhou, Xue] Heilongjiang Prov Ctr Dis Control & Prevent, Harbin 150030, Heilongjiang, Peoples R China.
   [Tammimies, Kristiina] Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, S-11330 Stockholm, Sweden.
RP Scherer, SW (reprint author), Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Ctr Appl Genom, 686 Bay St,Room 139800, Toronto, ON M5G 0A4, Canada.
EM stephen.scherer@sickkids.ca
RI Scherer, Stephen /B-3785-2013
OI Scherer, Stephen /0000-0002-8326-1999
FU Centre for Applied Genomics; University of Toronto McLaughlin Centre;
   NeuroDevNet; Genome Canada; Ontario Genomics Institute [4445]; Canadian
   Institutes for Health Research (CIHR) [FRN 74527, FRNXGG818]; Canadian
   Institute for Advanced Research; Canada Foundation for Innovation;
   Government of Ontario [GL2-01-013]; Ontario Brain Institute; Autism
   Speaks; Ontario Graduate Scholarship; Frederick Banting and Charles Best
   Canada Graduate Scholarship (CIHR-Masters)
FX The authors would like to thank Dr. Berivan Baskin and Dr. Peter Ray for
   scientific advice, Hong Yang Chen for technical assistance, and The
   Centre for Applied Genomics for support. This project was supported by
   grants from the University of Toronto McLaughlin Centre, NeuroDevNet,
   Genome Canada and the Ontario Genomics Institute (Project 4445), the
   Canadian Institutes for Health Research (CIHR) (FRN 74527 and
   FRNXGG818), the Canadian Institute for Advanced Research, the Canada
   Foundation for Innovation, the Government of Ontario (GL2-01-013), the
   Ontario Brain Institute, and Autism Speaks. MJG was supported by the
   Ontario Graduate Scholarship and a Frederick Banting and Charles Best
   Canada Graduate Scholarship (CIHR-Masters). SWS holds the
   GlaxoSmithKline-CIHR Chair in Genome Sciences at the University of
   Toronto and the Hospital for Sick Children.
CR Bi WM, 2009, NAT GENET, V41, P168, DOI 10.1038/ng.302
   Bisbal M, 2008, J NEUROSCI, V28, P9297, DOI 10.1523/JNEUROSCI.1879-08.2008
   Bochukova EG, 2010, NATURE, V463, P666, DOI 10.1038/nature08689
   Bruno DL, 2010, J MED GENET, V47, P299, DOI 10.1136/jmg.2009.069906
   Carter MT, 2013, CLIN GENET, V83, P399, DOI 10.1111/cge.12101
   Chowanadisai W, 2013, P NATL ACAD SCI USA, V110, P9903, DOI 10.1073/pnas.1222142110
   Curry CJ, 2013, AM J MED GENET A, V161, P1833, DOI 10.1002/ajmg.a.35996
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Egger G, 2014, NEUROGENETICS, V15, P117, DOI 10.1007/s10048-014-0394-0
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   Kamien B, 2014, AM J MED GENET A, V164, P1411, DOI 10.1002/ajmg.a.36458
   Lautier C, 2008, AM J HUM GENET, V82, P822, DOI 10.1016/j.ajhg.2008.01.015
   MacDonald JR, 2014, NUCLEIC ACIDS RES, V42, pD986, DOI 10.1093/nar/gkt958
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Matsunami N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0052239
   McGrath LM, 2014, J AM ACAD CHILD PSY, V53, P910, DOI 10.1016/j.jaac.2014.04.022
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Nagamani SCS, 2009, J MED GENET, V46, P825, DOI 10.1136/jmg.2009.067637
   Park H, 2010, NAT GENET, V42, P400, DOI 10.1038/ng.555
   Pinto D, 2011, NAT BIOTECHNOL, V29, P512, DOI 10.1038/nbt.1852
   Pinto D, 2014, AM J HUM GENET, V94, P677, DOI 10.1016/j.ajhg.2014.03.018
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Poultney CS, 2013, AM J HUM GENET, V93, P607, DOI 10.1016/j.ajhg.2013.09.001
   Prasad A, 2012, G3-GENES GENOM GENET, V2, P1665, DOI 10.1534/g3.112.004689
   Stafford RL, 2011, STRUCTURE, V19, P1826, DOI 10.1016/j.str.2011.09.018
   Sun X, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-7
   Toyo-oka K, 2003, NAT GENET, V34, P274, DOI 10.1038/ng1169
   Uddin M, 2014, NAT GENET, V46, P742, DOI 10.1038/ng.2980
   Wu JY, 2005, J CHILD NEUROL, V20, P790, DOI 10.1177/08830738050200100201
   Yu TA, 2011, DEVELOPMENT, V138, P2957, DOI 10.1242/dev.063784
   Zhou X, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027428
NR 32
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD AUG 23
PY 2014
VL 6
AR 34
DI 10.1186/1866-1955-6-34
PG 7
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO2PJ
UT WOS:000341166900001
PM 25170348
ER

PT J
AU Fields, C
AF Fields, Chris
TI Motion, identity and the bias toward agency
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE analogy; causal reasoning; infant cognition; mirror neuron system;
   structure mapping; systemizing
ID MIRROR NEURON SYSTEM; AUTISM SPECTRUM DISORDERS; BIOLOGICAL MOTION;
   SOCIAL BRAIN; OBJECT INDIVIDUATION; ATTENTIONAL ACCOUNT; INFANTS
   PERCEPTION; PRESCHOOLERS USE; EPISODIC MEMORY; SEX-DIFFERENCES
AB The well-documented human bias toward agency as a cause and therefore an explanation of observed events is typically attributed to evolutionary selection for a "social brain". Based on a review of developmental and adult behavioral and neurocognitive data, it is argued that the bias toward agency is a result of the default human solution, developed during infancy, to the computational requirements of object re-identification over gaps in observation of more than a few seconds. If this model is correct, overriding the bias toward agency to construct mechanistic explanations of observed events requires structure-mapping inferences, implemented by the pre-motor action planning system, that replace agents with mechanisms as causes of unobserved changes in contextual or featural properties of objects. Experiments that would test this model are discussed.
C1 [Fields, Chris] New Mexico State Univ, Las Cruces, NM 88003 USA.
EM fieldsres@gmail.com
CR Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514
   Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
   Aslin RN, 2007, DEVELOPMENTAL SCI, V10, P48, DOI 10.1111/j.1467-7687.2007.00563.x
   Auyeung B, 2009, J AUTISM DEV DISORD, V39, P1509, DOI 10.1007/s10803-009-0772-x
   Baillargeon R., 2012, LANGUAGE LEARNING DE, V8, P4
   Baillargeon R, 2008, PERSPECT PSYCHOL SCI, V3, P2, DOI 10.1111/j.1745-6916.2008.00056.x
   Baillargeon R., 2011, WILEY BLACKWELL HDB, P11
   Bardi L, 2011, DEVELOPMENTAL SCI, V14, P353, DOI 10.1111/j.1467-7687.2010.00985.x
   Baron-Cohen S, 2008, Q J EXP PSYCHOL, V61, P64, DOI 10.1080/17470210701508749
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Biro S, 2007, DEVELOPMENTAL SCI, V10, P379, DOI 10.1111/j.1467-7687.2006.00544.x
   Bloom P, 2007, DEVELOPMENTAL SCI, V10, P147, DOI 10.1111/j.1467-7687.2007.00577.x
   Boyer P, 2008, ANNU REV ANTHROPOL, V37, P111, DOI 10.1146/annurev.anthro.37.081407.085201
   Boyer TW, 2011, COGNITION, V121, P1, DOI 10.1016/j.cognition.2011.05.012
   Bremner JG, 2005, CHILD DEV, V76, P1029, DOI 10.1111/j.1467-8624.2005.00895.x
   Bremner JG, 2011, INFANT CHILD DEV, V20, P137, DOI 10.1002/icd.723
   Bremner JG, 2007, DEVELOPMENTAL SCI, V10, P613, DOI 10.1111/j.1467-7687.2007.00616.x
   Brosnan M, 2013, PSYCHOSIS, V5, P71, DOI 10.1080/17522439.2011.626526
   Brosnan M, 2010, PERS INDIV DIFFER, V49, P738, DOI 10.1016/j.paid.2010.06.018
   Bubic A, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00025
   Buchanan DW, 2011, CHILD DEV, V82, P2053, DOI 10.1111/j.1467-8624.2011.01646.x
   Bullot NJ, 2007, CONSCIOUS COGN, V16, P276, DOI 10.1016/j.concog.2006.09.006
   Cabeza R, 2008, NAT REV NEUROSCI, V9, P613, DOI 10.1038/nrn2459
   Casile A, 2011, NEUROSCIENTIST, V17, P524, DOI 10.1177/1073858410392239
   Catmur C, 2007, CURR BIOL, V17, P1527, DOI 10.1016/j.cub.2007.08.006
   Cattaneo L, 2009, ARCH NEUROL-CHICAGO, V66, P557, DOI 10.1001/archneurol.2009.41
   Cicchino JB, 2011, COGNITION, V118, P171, DOI 10.1016/j.cognition.2010.11.005
   Cook R, 2014, BEHAV BRAIN SCI, V37, P177, DOI 10.1017/S0140525X13000903
   Csibra G, 2008, COGNITION, V107, P705, DOI 10.1016/j.cognition.2007.08.001
   Csibra G., 2012, NAVIGATING SOCIAL WO, P38
   Del Giudice M, 2009, DEVELOPMENTAL SCI, V12, P350, DOI 10.1111/j.1467-7687.2008.00783.x
   DIPELLEGRINO G, 1992, EXP BRAIN RES, V91, P176
   Dunbar RIM, 2007, SCIENCE, V317, P1344, DOI 10.1126/science.1145463
   Dunbar RIM, 2003, ANNU REV ANTHROPOL, V32, P163, DOI 10.1146/annurev.anthro.32.061002.093158
   Eichenbaum H, 2007, ANNU REV NEUROSCI, V30, P123, DOI 10.1146/annurev.neuro.30.051606.094328
   Engel A, 2008, SOC NEUROSCI, V3, P368, DOI 10.1080/17470910701612793
   Fields C, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00049
   Fields C, 2011, PSYCHOL RES-PSYCH FO, V75, P129, DOI 10.1007/s00426-010-0290-7
   Fields C, 2012, MED HYPOTHESES, V79, P344, DOI 10.1016/j.mehy.2012.05.032
   Fields C, 2012, ADV COGN PSYCHOL, V8, P234, DOI [10.2478/v10053-008-0119-8, 10.5709/acp-0119-8]
   Fields C, 2011, PERS INDIV DIFFER, V50, P1159, DOI 10.1016/j.paid.2011.02.010
   Fields C, 2013, COGN PROCESS, V14, P217, DOI 10.1007/s10339-013-0555-3
   Fields C, 2012, COGN PROCESS, V13, P231, DOI 10.1007/s10339-012-0436-1
   Fields CA, 2013, HUM DEV, V56, P147, DOI 10.1159/000350206
   Flombaum J. I., 2008, ORIGINS OBJECT KNOWL, P135
   Frazier BN, 2009, COGNITIVE DEV, V24, P284, DOI 10.1016/j.cogdev.2009.06.003
   Gallese V, 2007, PHILOS T R SOC B, V362, P659, DOI 10.1098/rstb.2006.2002
   Gallese V, 2011, PERSPECT PSYCHOL SCI, V6, P369, DOI 10.1177/1745691611413392
   Gao T, 2010, PSYCHOL SCI, V21, P1845, DOI 10.1177/0956797610388814
   Gelman SA, 2011, ANNU REV ANTHROPOL, V40, P379, DOI 10.1146/annurev-anthro-081309-145822
   Gentner D, 2003, BRADFORD BOOKS, P195
   GENTNER D, 1983, COGNITIVE SCI, V7, P155, DOI 10.1207/s15516709cog0702_3
   Gentner D., 2002, INT ENCY SOCIAL BEHA, P9683
   Goldenfeld N., 2006, CLIN NEUROPSYCHIATRY, V2, P338
   Gould KL, 2010, PHILOS T R SOC B, V365, P901, DOI 10.1098/rstb.2009.0214
   Gutheil G, 2008, COGNITION, V107, P366, DOI 10.1016/j.cognition.2007.07.014
   Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
   Henrich J, 2010, BEHAV BRAIN SCI, V33, P61, DOI 10.1017/S0140525X0999152X
   Heyes C, 2012, PHILOS T R SOC B, V367, P2181, DOI 10.1098/rstb.2012.0120
   Heyes C, 2010, NEUROSCI BIOBEHAV R, V34, P575, DOI 10.1016/j.neubiorev.2009.11.007
   Holyoak K. J., 2005, CAMBRIDGE HDB THINKI, P117
   Hood BM, 2008, COGNITION, V106, P455, DOI 10.1016/j.cognition.2007.01.012
   Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
   Kamawari K., 2005, COGNITIVE DEV, V20, P303, DOI [10.1016/j.cogdev.2005.04.004, DOI 10.1016/J.COGDEV.2005.04.004]
   Kanakogi Y, 2011, NAT COMMUN, V2, DOI 10.1038/ncomms1342
   Karmiloff-Smith A., 1995, MODULARITY DEV PERSP
   Kelemen D, 2013, J EXP PSYCHOL GEN, V142, P1074, DOI 10.1037/a0030399
   Kelemen D., 2012, EVOLUTION CHALLENGES, P66
   Kelemen D, 2004, PSYCHOL SCI, V15, P295, DOI 10.1111/j.0956-7976.2004.00672.x
   Kosslyn S. M., 2006, CASE MENTAL IMAGERY
   Kuhlmeier A. A., 2010, INFANCY, V15, P83, DOI [10.1111/j.1532-7078.2009.00003.x, DOI 10.1111/J.1532-7078.2009.00003.X]
   Kushnir T, 2007, DEV PSYCHOL, V43, P186, DOI 10.1037/0012-1649.43.1.186
   Legare CH, 2012, CHILD DEV, V83, P779, DOI 10.1111/j.1467-8624.2012.01743.x
   Lewis JW, 2006, NEUROSCIENTIST, V12, P211, DOI 10.1177/1073858406288327
   Loewenstein J, 2005, COGNITIVE PSYCHOL, V50, P315, DOI 10.1016/j.cogpsych.2004.09.004
   Luo YY, 2010, CURR DIR PSYCHOL SCI, V19, P301, DOI 10.1177/0963721410386679
   Luo YY, 2009, COGNITIVE PSYCHOL, V58, P441, DOI 10.1016/j.cogpsych.2008.11.001
   Luo YY, 2011, DEVELOPMENTAL SCI, V14, P453, DOI 10.1111/j.1467-7687.2010.00995.x
   Markman AB, 2001, ANNU REV PSYCHOL, V52, P223, DOI 10.1146/annurev.psych.52.1.223
   Marshall PJ, 2011, DEV COGN NEUROS-NETH, V1, P110, DOI 10.1016/j.dcn.2010.09.001
   Martin A, 2007, ANNU REV PSYCHOL, V58, P25, DOI 10.1146/annurev.psych.57.102904.190143
   McCloskey M., 1983, MENTAL MODELS, P299
   Moscovitch M, 2008, CAN J EXP PSYCHOL, V62, P62, DOI 10.1037/1196-1961.62.1.62
   Moulton ST, 2009, PHILOS T R SOC B, V364, P1273, DOI 10.1098/rstb.2008.0314
   Munakata Y, 2001, J COGNITIVE NEUROSCI, V13, P44, DOI 10.1162/089892901564162
   Nassi JJ, 2009, NAT REV NEUROSCI, V10, P360, DOI 10.1038/nrn2619
   Needham A, 2005, COGNITION, V94, P215, DOI 10.1016/j.cognition.2004.02.002
   Nettle D, 2007, BRIT J PSYCHOL, V98, P237, DOI 10.1348/000712606X117612
   Nystrom P, 2011, DEVELOPMENTAL SCI, V14, P327, DOI 10.1111/j.1467-7687.2010.00979.x
   Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
   Paul G, 2009, EVOL PSYCHOL, V7, P398
   Paulus M, 2012, PSYCHOL RES-PSYCH FO, V76, P760, DOI 10.1007/s00426-011-0385-9
   Paulus M, 2012, HUM DEV, V55, P107, DOI 10.1159/000339442
   Pavlova MA, 2012, CEREB CORTEX, V22, P981, DOI 10.1093/cercor/bhr156
   PINTRICH PR, 1993, REV EDUC RES, V63, P167, DOI 10.3102/00346543063002167
   Rakison DH, 2010, WIRES COGN SCI, V1, P894, DOI 10.1002/wcs.81
   Ranganath C, 2010, HIPPOCAMPUS, V20, P1263, DOI 10.1002/hipo.20852
   Ray E, 2011, DEVELOPMENTAL SCI, V14, P92, DOI 10.1111/j.1467-7687.2010.00961.x
   Rips LJ, 2006, PSYCHOL REV, V113, P1, DOI 10.1037/0033-295X.113.1.1
   Rizzolatti G, 2003, EXP BRAIN RES, V153, P146, DOI 10.1007/s00221-003-1588-0
   Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
   Rosset E, 2008, COGNITION, V108, P771, DOI 10.1016/j.cognition.2008.07.001
   Rottman J., 2012, SCI WORLDS RELIG, V1, P205
   Saxe R, 2004, ANNU REV PSYCHOL, V55, P87, DOI 10.1146/annurev.psych.55.090902.142044
   Schiaffino S, 2004, INT J HUM-COMPUT ST, V60, P129, DOI [10.1016/j.ijhcs.2003.09.003, 10.1016/jijhcs.2003.09.003]
   Scholl BJ, 2013, SOCIAL PERCEPTION: DETECTION AND INTERPRETATION OF ANIMACY, AGENCY, AND INTENTION, P197
   Scholl BJ, 2007, MIND LANG, V22, P563, DOI 10.1111/j.1468-0017.2007.00321.x
   Scholl BJ, 2000, TRENDS COGN SCI, V4, P299, DOI 10.1016/S1364-6613(00)01506-0
   Schubotz RI, 2004, J NEUROSCI, V24, P5467, DOI 10.1523/JNEUROSCI.1169-04.2004
   Schubotz RI, 2007, TRENDS COGN SCI, V11, P211, DOI 10.1016/j.tics.2007.02.006
   Segal Robert A., 2006, BLACKWELL COMPANION
   Simion F, 2008, P NATL ACAD SCI USA, V105, P809, DOI 10.1073/pnas.0707021105
   Simion F, 2011, PROG BRAIN RES, V189, P173, DOI 10.1016/B978-0-444-53884-0.00024-5
   Sobel DM, 2009, COGNITIVE DEV, V24, P274, DOI 10.1016/j.cogdev.2009.03.003
   Sobel DM, 2009, DEV PSYCHOL, V45, P511, DOI 10.1037/a0014944
   Sobel DM, 2007, J COGN DEV, V8, P159, DOI 10.1080/15248370701202356
   Southgate V, 2009, BIOL LETTERS, V5, P769, DOI 10.1098/rsbl.2009.0474
   SPELKE E, 1994, COGNITION, V50, P431, DOI 10.1016/0010-0277(94)90039-6
   Treisman A., 2006, HDB BINDING MEMORY P, P315
   Turk-Browne NB, 2008, FRONT HUM NEUROSCI, V2, DOI 10.3389/neuro.09.016.2008
   Uncapher MR, 2009, NEUROBIOL LEARN MEM, V91, P139, DOI 10.1016/j.nlm.2008.10.011
   Vaden VC, 2011, CHILD DEV, V82, P1120, DOI 10.1111/j.1467-8624.2011.01589.x
   Virji-Babul N, 2012, BRAIN BEHAV, V2, P237, DOI 10.1002/brb3.50
   Waytz A, 2010, TRENDS COGN SCI, V14, P383, DOI 10.1016/j.tics.2010.05.006
   Whitehead C, 2001, J CONSCIOUSNESS STUD, V8, P3
   Woodward AL, 2009, PSYCHOL LEARN MOTIV, V51, P187, DOI 10.1016/S0079-7421(09)51006-7
   Woodward AL, 2009, CURR DIR PSYCHOL SCI, V18, P53, DOI 10.1111/j.1467-8721.2009.01605.x
   Woolley J. D., 2011, J COGNITION CULTURE, V11, P311, DOI [10.1163/156853711x591279, DOI 10.1163/156853711X591279]
   Xu F, 2007, TRENDS COGN SCI, V11, P400, DOI 10.1016/j.tics.2007.08.002
   Zimmer HD, 2010, NEUROSCI BIOBEHAV R, V34, P1066, DOI 10.1016/j.neubiorev.2010.01.014
NR 131
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD AUG 21
PY 2014
VL 8
AR 597
DI 10.3389/fnhum.2014.00597
PG 13
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AN7YP
UT WOS:000340817200001
PM 25191245
ER

PT J
AU Hogan-Brown, AL
   Hoedemaker, RS
   Gordon, PC
   Losh, M
AF Hogan-Brown, Abigail L.
   Hoedemaker, Renske S.
   Gordon, Peter C.
   Losh, Molly
TI Eye-voice span during rapid automatized naming: evidence of reduced
   automaticity in individuals with autism spectrum disorder and their
   siblings
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Siblings; Language; Rapid automatized naming;
   Eye tracking; Endophenotype
ID DYSLEXIA; CHILDREN; DEFICITS; DISABILITIES; FLUENCY; FAMILY; RISK; RAN
AB Background: Individuals with autism spectrum disorder (ASD) and their parents demonstrate impaired performance in rapid automatized naming (RAN), a task that recruits a variety of linguistic and executive processes. Though the basic processes that contribute to RAN differences remain unclear, eye-voice relationships, as measured through eye tracking, can provide insight into cognitive and perceptual processes contributing to RAN performance. For example, in RAN, eye-voice span (EVS), the distance ahead the eyes are when articulation of a target item's label begins, is an indirect measure of automaticity of the processes underlying RAN. The primary objective of this study was to investigate automaticity in naming processes, as indexed by EVS during RAN. The secondary objective was to characterize RAN difficulties in individuals with ASD and their siblings.
   Methods: Participants (aged 15-33 years) included 21 individuals with ASD, 23 siblings of individuals with ASD, and 24 control subjects, group-matched on chronological age. Naming time, frequency of errors, and EVS were measured during a RAN task and compared across groups.
   Results: A stepwise pattern of RAN performance was observed, with individuals with ASD demonstrating the slowest naming across all RAN conditions, controls demonstrating the fastest naming, and siblings demonstrating intermediate performance. Individuals with ASD exhibited smaller EVSs than controls on all RAN conditions, and siblings exhibited smaller EVSs during number naming (the most highly automatized type of naming). EVSs were correlated with naming times in controls only, and only in the more automatized conditions.
   Conclusions: These results suggest that reduced automaticity in the component processes of RAN may underpin differences in individuals with ASD and their siblings. These findings also provide further support that RAN abilities are impacted by genetic liability to ASD. This study has important implications for understanding the underlying skills contributing to language-related deficits in ASD.
C1 [Hogan-Brown, Abigail L.; Losh, Molly] Northwestern Univ, Roxelyn & Richard Pepper Dept Commun Sci & Disord, Evanston, IL 60208 USA.
   [Hoedemaker, Renske S.; Gordon, Peter C.] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA.
RP Losh, M (reprint author), Northwestern Univ, Roxelyn & Richard Pepper Dept Commun Sci & Disord, Evanston, IL 60208 USA.
EM m-losh@northwestern.edu
RI Hogan-Brown, Abigail/I-8091-2012
OI Hogan-Brown, Abigail/0000-0002-2913-7356
FU National Institute of Deafness and Other Communication Disorders
   [R01DC010191, T32DC009399]
FX This study was supported by grants R01DC010191 and T32DC009399 from the
   National Institute of Deafness and Other Communication Disorders. The
   study sponsors had no role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data;
   preparation, review, or approval of the manuscript; and decision to
   submit the manuscript for publication. We also acknowledge the support
   of the Research Participant Registry Core of the Carolina Institute for
   Developmental Disabilities (P30HD03110) for their role in participant
   recruitment. The authors would like to thank Sejal Shah and Bret Kravis
   for their assistance with data processing. The authors are also grateful
   to the individuals and families who participated in this study.
CR AKSHOOMOFF NA, 1992, NEUROPSYCHOLOGIA, V30, P315, DOI 10.1016/0028-3932(92)90105-U
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Benson V, 2011, OXFORD HDB EYE MOVEM, P709
   Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
   Chow BW-Y, 2011, PLOS ONE, V6, P1
   COHEN JD, 1992, AM J PSYCHOL, V105, P239, DOI 10.2307/1423029
   Davis CJ, 2001, ANN DYSLEXIA, V51, P231, DOI 10.1007/s11881-001-0012-3
   de Kovel CGF, 2008, AM J MED GENET B, V147B, P294, DOI 10.1002/ajmg.b.30598
   DENCKLA M B, 1974, Cortex, V10, P186
   Denckla M B, 1972, Cortex, V8, P164
   DENCKLA MB, 1976, BRAIN LANG, V3, P1, DOI 10.1016/0093-934X(76)90001-8
   DENCKLA MB, 1976, NEUROPSYCHOLOGIA, V14, P471, DOI 10.1016/0028-3932(76)90075-0
   Deutsch GK, 2005, CORTEX, V41, P354, DOI 10.1016/S0010-9452(08)70272-7
   Eckert MA, 2003, BRAIN, V126, P482, DOI 10.1093/brain/awg026
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Hus V, 2014, J AUTISM DEV DISORD, V44, P1
   Jones MW, 2010, COGNITION, V116, P56, DOI 10.1016/j.cognition.2010.03.015
   Jones MW, 2008, COGNITION, V109, P389, DOI 10.1016/j.cognition.2008.10.005
   Jones MW, 2013, J EXP PSYCHOL HUMAN, V39, P554, DOI 10.1037/a0029710
   Leonard CM, 2001, CEREB CORTEX, V11, P148, DOI 10.1093/cercor/11.2.148
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   Losh M, 2010, J NEURODEV DISORD, V2, P109, DOI 10.1007/s11689-010-9045-4
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   Misra M, 2004, SCI STUD READ, V8, P241, DOI 10.1207/s1532799xssr0803_4
   Nopola-Hemmi J, 2002, DEV MED CHILD NEUROL, V44, P580
   Pan J, 2013, DEVELOPMENTAL SCI, V16, P967, DOI 10.1111/desc.12075
   Pennington BF, 2001, CHILD DEV, V72, P816, DOI 10.1111/1467-8624.00317
   Petrill SA, 2006, J EDUC PSYCHOL, V98, P112, DOI 10.1037/0022-0663.98.1.112
   Piven J, 1997, J CHILD PSYCHOL PSYC, V38, P1011, DOI 10.1111/j.1469-7610.1997.tb01618.x
   Rayner K, 1998, PSYCHOL BULL, V124, P372, DOI 10.1037/0033-2909.124.3.372
   Semrud-Clikeman M, 2000, BRAIN LANG, V74, P70, DOI 10.1006/brln.2000.2337
   Stringer RW, 2004, READING WRITING INTE, V17, P891, DOI 10.1007/s11145-004-2770-x
   Wagner R., 1999, COMPREHENSIVE TEST P
   Wechsler D., 2008, WECHSLER ADULT INTEL
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Yuan J, 2008, J ACOUST SOC AM, V123, P3878, DOI 10.1121/1.2935783
NR 39
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD AUG 21
PY 2014
VL 6
AR 33
DI 10.1186/1866-1955-6-33
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO2PI
UT WOS:000341166800001
PM 25177372
ER

PT J
AU James, WH
AF James, William H.
TI An update on the hypothesis that one cause of autism is high
   intrauterine levels of testosterone of maternal origin
SO JOURNAL OF THEORETICAL BIOLOGY
LA English
DT Article
DE Sex ratio; Risk factors; Multifactorial threshold inheritance
ID MAMMALIAN SEX-RATIOS; PARENTAL HORMONE-LEVELS; 4TH DIGIT RATIO;
   PERINATAL RISK-FACTORS; MALE BRAIN THEORY; SPECTRUM DISORDERS;
   COMPREHENSIVE METAANALYSIS; GROWTH-RETARDATION; LIFE-STYLE; PREGNANCY
AB Baron-Cohen's hypothesis that autism is caused by exposure to high intrauterine testosterone levels is considered in the context of (1) my hormonal hypothesis of sex ratio and (2) the notion of multifactorial inheritance. This yields the suggestions that (1) female cases of autism may be the product of (high genetic loading+moderate environmental exposure) and male cases of (high environmental exposure+moderate genetic loading), (2) one environmental agent is intrauterine testosterone and (3) the mother is the major source of that testosterone. These suggestions may help to explain most of the major established epidemiological risk factors for autism. These include various forms of pathology associated with psychological and/or physical stress. Stress of many sorts promotes the secretion of adrenal androgens in women. The three suggestions above may also explain some recently described features of autism including the psychological, behavioural and neuroanatomical differences between male and female cases. (C) 2014 Elsevier Ltd. All rights reserved.
C1 UCL, Dept Genet Evolut & Environm, Galton Lab, London WC1 6BT, England.
RP James, WH (reprint author), UCL, Dept Genet Evolut & Environm, Galton Lab, Gower St, London WC1 6BT, England.
EM w.james@ucl.ac.uk
CR Anello A, 2009, J AUTISM DEV DISORD, V39, P1487, DOI 10.1007/s10803-009-0755-y
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   APTER D, 1990, J CLIN ENDOCR METAB, V71, P970
   Auger J, 2011, INT J ANDROL, V34, pE49, DOI 10.1111/j.1365-2605.2010.01124.x
   BAISCHER W, 1995, PSYCHONEUROENDOCRINO, V20, P553, DOI 10.1016/0306-4530(94)00081-K
   Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
   Beaudet AL, 2012, SCIENCE, V338, P342, DOI 10.1126/science.1229178
   Bejerot S, 2012, BRIT J PSYCHIAT, V201, P116, DOI 10.1192/bjp.bp.111.097899
   Berenbaum SA, 2009, ENDOCRINOLOGY, V150, P5119, DOI 10.1210/en.2009-0774
   Breedlove SM, 2010, ENDOCRINOLOGY, V151, P4116, DOI 10.1210/en.2010-0041
   Bryant DM, 2011, J NEUROSCI, V31, P6654, DOI 10.1523/JNEUROSCI.5899-10.2011
   Chao H.H., 2013, PLOS ONE, V8
   Cheema M, 2011, BRIT J CANCER, V105, P466, DOI 10.1038/bjc.2011.232
   Cheslack-Postava K, 2011, PEDIATRICS, V127, P246, DOI 10.1542/peds.2010-2371
   D'Onofrio BM, 2008, DEV PSYCHOPATHOL, V20, P139, DOI 10.1017/S0954579408000072
   Dressler SG, 2011, DEV PSYCHOBIOL, V53, P69, DOI 10.1002/dev.20488
   Ellis L., 2009, PERS INDIV DIFFER, V47, P447
   ELLIS L, 1986, PERS INDIV DIFFER, V7, P519, DOI 10.1016/0191-8869(86)90131-5
   Ellis LC, 2012, EUR CHILD ADOLES PSY, V21, P635, DOI 10.1007/s00787-012-0300-y
   Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508
   Fowler PA, 2011, J CLIN ENDOCR METAB, V96, pE1502, DOI 10.1210/jc.2011-1100
   Garcia-Cruz E, 2012, BJU INT, V109, P266, DOI 10.1111/j.1464-410X.2011.10249.x
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
   GOLDBERG M, 1995, J CLIN ENDOCR METAB, V80, P3390, DOI 10.1210/jc.80.11.3390
   Grether JK, 2006, CLIN NEUROSCI RES, V6, P119, DOI 10.1016/j.cnr.2006.06.009
   Gronborg TK, 2013, JAMA PEDIATR, V167, P947, DOI 10.1001/jamapediatrics.2013.2259
   Gunnes N, 2013, EPIDEMIOLOGY, V24, P906, DOI 10.1097/01.ede.0000434435.52506.f5
   Haglund NGS, 2011, AUTISM, V15, P163, DOI 10.1177/1362361309353614
   Hill JO, 2013, DIABETES CARE, V36, P2430, DOI 10.2337/dc13-1161
   Honekopp J, 2007, PSYCHONEUROENDOCRINO, V32, P313, DOI 10.1016/j.psyneuen.2007.01.007
   Howard JM, 2006, ARCH DIS CHILD, V91, P622
   Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
   Indredavik MS, 2007, ACTA PAEDIATR, V96, P377, DOI 10.1111/j.1651-2227.2006.00148.x
   James WH, 2012, DEV MED CHILD NEUROL, V54, P301, DOI 10.1111/j.1469-8749.2012.04225.x
   James WH, 2004, HUM REPROD, V19, P1250, DOI 10.1093/humrep/deh245
   James WH, 2008, J ENDOCRINOL, V198, P3, DOI 10.1677/JOE-07-0446
   JAMES WH, 1986, J THEOR BIOL, V118, P427, DOI 10.1016/S0022-5193(86)80163-1
   James WH, 2013, J THEOR BIOL, V334, P141, DOI 10.1016/j.jtbi.2013.06.023
   James WH, 2008, DEV MED CHILD NEUROL, V50, P15, DOI [10.1111/j.1469-8749.2007.02001.x, 10.1111/j.1469-8749.2007.0200.x]
   JAMES WH, 1987, HUM BIOL, V59, P721
   James WH, 2010, J BIOSOC SCI, V42, P587, DOI 10.1017/S002193201000012X
   James WH, 1996, J THEOR BIOL, V180, P271, DOI 10.1006/jtbi.1996.0102
   Kaergaard A, 2000, SCAND J WORK ENV HEA, V26, P292
   Kalkbrenner AE, 2012, ENVIRON HEALTH PERSP, V120, P1042, DOI 10.1289/ehp.1104556
   Kemper T. D., 1990, SOCIAL STRUCTURE TES
   Keyes KM, 2012, INT J EPIDEMIOL, V41, P495, DOI 10.1093/ije/dyr193
   Kirkovski M, 2013, J AUTISM DEV DISORD, V43, P2584, DOI 10.1007/s10803-013-1811-1
   Kuo PX, 2012, BIOL PSYCHOL, V91, P302, DOI 10.1016/j.biopsycho.2012.08.002
   Lai MC, 2013, BRAIN, V136, P2799, DOI 10.1093/brain/awt216
   Langley K, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-26
   Langley K, 2012, AM J EPIDEMIOL, V176, P261, DOI 10.1093/aje/kwr510
   Larsson M, 2009, NEUROTOXICOLOGY, V30, P822, DOI 10.1016/j.neuro.2009.01.011
   Lee BK, 2012, J AUTISM DEV DISORD, V42, P2000, DOI 10.1007/s10803-011-1425-4
   Linnet KM, 2005, PEDIATRICS, V116, P462, DOI 10.1542/peds.2004-2054
   Linnet KM, 2003, AM J PSYCHIAT, V160, P1028, DOI 10.1176/appi.ajp.160.6.1028
   Lutchmaya S, 2004, EARLY HUM DEV, V77, P23, DOI 10.1016/j.earlhumdev.2003.12.002
   Macri S, 2010, PSYCHONEUROENDOCRINO, V35, P1374, DOI 10.1016/j.psyneuen.2010.03.012
   Manikkam M, 2004, ENDOCRINOLOGY, V145, P790, DOI 10.1210/en.2003-0478
   Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317
   Manning JT, 1998, HUM REPROD, V13, P3000, DOI 10.1093/humrep/13.11.3000
   Mascaro JS, 2013, P NATL ACAD SCI USA, V110, P15746, DOI 10.1073/pnas.1305579110
   Mouridsen SE, 2010, DEV MED CHILD NEUROL, V52, P289, DOI 10.1111/j.1469-8749.2009.03368.x
   Mouridsen S.E., CHILD PSYCH IN PRESS
   Mouridsen SE, 2010, LOGOP PHONIATR VOCO, V35, P144, DOI 10.3109/14015430903518007
   Mrozek-Budzyn D, 2013, CENT EUR J MED, V8, P424, DOI 10.2478/s11536-013-0174-5
   Muller DC, 2011, REPROD BIOL ENDOCRIN, V9, DOI 10.1186/1477-7827-9-57
   Padmanabhan V, 2006, MOL CELL ENDOCRINOL, V246, P165, DOI 10.1016/j.mce.2005.11.016
   Palomba S, 2012, CLIN ENDOCRINOL, V77, P898, DOI 10.1111/j.1365-2265.2012.04443.x
   Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
   Polkki M, 2009, AM J PUBLIC HEALTH, V99, P1350, DOI 10.2105/AJPH.2009.163485
   Powell LH, 2002, PSYCHOSOM MED, V64, P502
   Recabarren MP, 2013, REPRODUCTION, V145, P567, DOI 10.1530/REP-13-0006
   Recabarren SE, 2008, ENDOCRINOLOGY, V149, P6444, DOI 10.1210/en.2008-0785
   Robinson EB, 2013, P NATL ACAD SCI USA, V110, P5258, DOI 10.1073/pnas.1211070110
   Roos A, 2011, BEHAV BRAIN RES, V222, P200, DOI 10.1016/j.bbr.2011.03.055
   Ruta L, 2011, PSYCHONEUROENDOCRINO, V36, P1154, DOI 10.1016/j.psyneuen.2011.02.007
   Rutter M, 2009, INT J EPIDEMIOL, V38, P1238, DOI 10.1093/ije/dyp257
   Sarachana T, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-39
   Schieve LA, 2012, DISABIL HEALTH J, V5, P18, DOI 10.1016/j.dhjo.2011.09.001
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
   Sowers MF, 2001, AM J EPIDEMIOL, V153, P256, DOI 10.1093/aje/153.3.256
   Steckler T, 2005, ENDOCRINOLOGY, V146, P3185, DOI 10.1210/en.2004-1444
   St Pourcain B, 2011, J AM ACAD CHILD PSY, V50, P892, DOI 10.1016/j.jaac.2011.05.015
   Sumi S, 2006, J HUM GENET, V51, P518, DOI 10.1007/s10038-006-0392-7
   Teatero ML, 2013, J AUTISM DEV DISORD, V43, P2664, DOI 10.1007/s10803-013-1819-6
   Thornhill Randy, 1996, Trends in Ecology and Evolution, V11, P98, DOI 10.1016/0169-5347(96)81051-2
   Toriola AT, 2011, OBSTET GYNECOL, V118, P1029, DOI 10.1097/AOG.0b013e3182342b7f
   Tran PL, 2013, PAEDIATR PERINAT EP, V27, P266, DOI 10.1111/ppe.12043
   TRIVERS RL, 1973, SCIENCE, V179, P90, DOI 10.1126/science.179.4068.90
   van der Ven E, 2013, ACTA PSYCHIAT SCAND, V128, P54, DOI 10.1111/acps.12054
   Visser JC, 2013, J AUTISM DEV DISORD, V43, P1505, DOI 10.1007/s10803-012-1678-6
   Voracek M, 2010, SCAND J PSYCHOL, V51, P146, DOI 10.1111/j.1467-9450.2009.00758.x
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   WING L, 1981, PSYCHIAT RES, V5, P129, DOI 10.1016/0165-1781(81)90043-3
   Wolpert C, 2004, GENET MED, V6, P314
   Xu X.J., 2013, PLOS ONE, V9, P8
NR 100
TC 0
Z9 0
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-5193
EI 1095-8541
J9 J THEOR BIOL
JI J. Theor. Biol.
PD AUG 21
PY 2014
VL 355
BP 33
EP 39
DI 10.1016/j.jtbi.2014.03.036
PG 7
WC Biology; Mathematical & Computational Biology
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology
GA AJ7GL
UT WOS:000337865100004
PM 24703983
ER

PT J
AU Righi, G
   Tierney, AL
   Tager-Flusberg, H
   Nelson, CA
AF Righi, Giulia
   Tierney, Adrienne L.
   Tager-Flusberg, Helen
   Nelson, Charles A.
TI Functional Connectivity in the First Year of Life in Infants at Risk for
   Autism Spectrum Disorder: An EEG Study
SO PLOS ONE
LA English
DT Article
ID BRAIN; LANGUAGE; ACTIVATION; COHERENCE; CHILDREN; SPEECH;
   UNDERCONNECTIVITY; REPRESENTATIONS; SYNCHRONIZATION; TODDLERS
AB In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants who have a significant family history of autism spectrum disorder, given the increased prevalence observed among such infants. In the present study we tested infants at high-and low-risk for ASD (based on having an older sibling diagnosed with the disorder or not) at 6-and 12-months-of-age. We computed intrahemispheric linear coherence between anterior and posterior sites as a measure of neural functional connectivity derived from electroencephalography while the infants were listening to speech sounds. We found that by 12-months-of-age infants at risk for ASD showed reduced functional connectivity compared to low risk infants. Moreover, by 12-months-of-age infants later diagnosed with ASD showed reduced functional connectivity, compared to both infants at low risk for the disorder and infants at high risk who were not later diagnosed with ASD. Significant differences in functional connectivity were also found between low-risk infants and high-risk infants who did not go onto develop ASD. These results demonstrate that reduced functional connectivity appears to be related to genetic vulnerability for ASD. Moreover, they provide further evidence that ASD is broadly characterized by differences in neural integration that emerge during the first year of life.
C1 [Righi, Giulia] Univ Massachusetts, Dept Psychol, Amherst, MA 01003 USA.
   [Tierney, Adrienne L.] Harvard Univ, Harvard Coll Writing Program, Cambridge, MA 02138 USA.
   [Tager-Flusberg, Helen] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA.
   [Nelson, Charles A.] Boston Childrens Hosp, Div Dev Med, Boston, MA 02115 USA.
   [Nelson, Charles A.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
   [Nelson, Charles A.] Harvard Univ, Grad Sch Educ, Cambridge, MA 02138 USA.
RP Nelson, CA (reprint author), Boston Childrens Hosp, Div Dev Med, Boston, MA 02115 USA.
EM charles_nelson@harvard.edu
FU National Institute on Deafness and Other Communication Disorders (NIDCD)
   [R21 DC 08637]; Autism Speaks; NIDCD [RO1 DC 10290]; Simon's Foundation
FX Funding was provided by grant from National Institute on Deafness and
   Other Communication Disorders (NIDCD) R21 DC 08637 and Autism Speaks to
   HTF. Funding was provided by grant NIDCD RO1 DC 10290 and the Simon's
   Foundation to CAN and HTF. The agencies/funders had NO role in design
   data analysis or publication.
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Barnea-Goraly N, 2010, ARCH GEN PSYCHIAT, V67, P1052, DOI 10.1001/archgenpsychiatry.2010.123
   Bosl W, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-18
   Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
   Catarino A, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-1
   Cheour M, 1998, NAT NEUROSCI, V1, P351, DOI 10.1038/1561
   Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
   Delorme A, 2004, J NEUROSCI METH, V134, P9, DOI 10.1016/j.jneumeth.2003.10.009
   Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
   Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
   Eyler LT, 2012, BRAIN, V135, P949, DOI 10.1093/brain/awr364
   Gabard-Durnam L, 2013, J AUTISM DEV DISORD, P1
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Goncharova II, 2003, CLIN NEUROPHYSIOL, V114, P1580, DOI 10.1016/S1388-2457(03)00093-2
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015
   Hoehl S, 2012, DEV NEUROPSYCHOL, V37, P187, DOI 10.1080/87565641.2011.627958
   Jones EJH, 2014, NEUROSCI BIOBEHAV R, V39, P1, DOI 10.1016/j.neubiorev.2013.12.001
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kawahara H, 1999, SPEECH COMMUN, V27, P187, DOI 10.1016/S0167-6393(98)00085-5
   Keehn B, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00444
   Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216
   KUHL PK, 1992, SCIENCE, V255, P606, DOI 10.1126/science.1736364
   Lindgren KA, 2009, AUTISM RES, V2, P22, DOI 10.1002/aur.63
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mullen E, 1995, MULLEN SCALES EARLY
   Murdoch JD, 2013, CURR OPIN GENET DEV, V23, P310, DOI 10.1016/j.gde.2013.02.003
   Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
   Ozonoff S., 2011, PEDIATRICS, V128, P488, DOI DOI 10.1542/PEDS.2010-2825
   Peters JM, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-54
   Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020
   Rivera-Gaxiola M, 2005, DEVELOPMENTAL SCI, V8, P162, DOI 10.1111/j.1467-7687.2005.00403.x
   Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
   Rutter M., 2003, SOCIAL COMMUNICATION
   Seery AM, 2012, DEV COGN NEUROSCI C, V5C, P10
   Tager-Flusberg H, 2010, NEURAL NETWORKS, V23, P1072, DOI 10.1016/j.neunet.2010.07.008
   Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
   Tierney AL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039127
   Toth K, 2007, J AUTISM DEV DISORD, V37, P145, DOI 10.1007/s10803-006-0336-2
   Uhlhaas Peter J, 2006, Neuron, V52, P155, DOI 10.1016/j.neuron.2006.09.020
   Viding E, 2007, BEHAV GENET, V37, P51, DOI 10.1007/s10519-006-9105-4
   Wolff JJ, 2011, AM J PSYCHIAT, V169, P589
   Yuval-Greenberg S, 2008, NEURON, V58, P429, DOI 10.1016/j.neuron.2008.03.027
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
   Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
NR 47
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 20
PY 2014
VL 9
IS 8
AR e105176
DI 10.1371/journal.pone.0105176
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AQ3JB
UT WOS:000342687200057
PM 25140874
ER

PT J
AU Qureshi, AY
   Mueller, S
   Snyder, AZ
   Mukherjee, P
   Berman, JI
   Roberts, TPL
   Nagarajan, SS
   Spiro, JE
   Chung, WK
   Sherr, EH
   Buckner, RL
AF Qureshi, Abid Y.
   Mueller, Sophia
   Snyder, Abraham Z.
   Mukherjee, Pratik
   Berman, Jeffrey I.
   Roberts, Timothy P. L.
   Nagarajan, Srikantan S.
   Spiro, John E.
   Chung, Wendy K.
   Sherr, Elliott H.
   Buckner, Randy L.
CA Simons VIP Consortium
TI Opposing Brain Differences in 16p11.2 Deletion and Duplication Carriers
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE 16p11.2; ASD; CNV; copy number variation; morphometry; structural MRI
ID AUTISM SPECTRUM DISORDER; SURFACE-BASED ANALYSIS; WHITE-MATTER; CORTICAL
   THICKNESS; HEAD CIRCUMFERENCE; NORMAL INDIVIDUALS; COSTELLO SYNDROME;
   HUMAN NEOCORTEX; CHILDREN; VOLUME
AB Deletions and duplications of the recurrent similar to 600 kb chromosomal BP4-BP5 region of 16p11.2 are associated with a broad variety of neurodevelopmental outcomes including autism spectrum disorder. A clue to the pathogenesis of the copy number variant (CNV)'s effect on the brain is that the deletion is associated with a head size increase, whereas the duplication is associated with a decrease. Here we analyzed brain structure in a clinically ascertained group of human deletion (N = 25) and duplication (N = 17) carriers from the Simons Variation in Individuals Project compared with age-matched controls (N = 29 and 33, respectively). Multiple brain measures showed increased size in deletion carriers and reduced size in duplication carriers. The effects spanned global measures of intracranial volume, brain size, compartmental measures of gray matter and white matter, subcortical structures, and the cerebellum. Quantitatively, the largest effect was on the thalamus, but the collective results suggest a pervasive rather than a selective effect on the brain. Detailed analysis of cortical gray matter revealed that cortical surface area displays a strong dose-dependent effect of CNV (deletion > control > duplication), whereas average cortical thickness is less affected. These results suggest that the CNV may exert its opposing influences through mechanisms that influence early stages of embryonic brain development.
C1 [Qureshi, Abid Y.; Buckner, Randy L.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
   [Qureshi, Abid Y.; Buckner, Randy L.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA.
   [Qureshi, Abid Y.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
   [Buckner, Randy L.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Mueller, Sophia; Buckner, Randy L.] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA.
   [Mueller, Sophia] Univ Munich, Inst Clin Radiol, D-81377 Munich, Germany.
   [Snyder, Abraham Z.] Washington Univ, Sch Med St Louis, Dept Neurol, St Louis, MO 63110 USA.
   [Snyder, Abraham Z.] Washington Univ, Sch Med St Louis, Dept Radiol, St Louis, MO 63110 USA.
   [Mukherjee, Pratik; Nagarajan, Srikantan S.] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94158 USA.
   [Sherr, Elliott H.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA.
   [Berman, Jeffrey I.; Roberts, Timothy P. L.] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA.
   [Spiro, John E.] Simons Fdn, New York, NY 10010 USA.
   [Chung, Wendy K.] Columbia Univ, Med Ctr, Dept Pediat & Med, New York, NY 10032 USA.
RP Buckner, RL (reprint author), Harvard Univ, Northwest Bldg,Room 280-06,52 Oxford St, Cambridge, MA 02138 USA.
EM randy_buckner@harvard.edu
FU Simons Foundation (SFARI) [219193]; NIH/NINDS [5R25NS065743]
FX This work was supported by a Grant from the Simons Foundation (SFARI no.
   219193 to R.B.). We thank all of the families at the participating
   Simons Variation in Individuals Project (VIP) sites, as well as the
   Simons VIP Consortium. We appreciate obtaining access to phenotypic data
   on SFARI Base. Approved researchers can obtain the Simons VIP population
   dataset described in this study by contacting the Simons Foundation
   Autism Research Initiative. A.Q. was supported by NIH/NINDS
   5R25NS065743. We thank Avram Holmes for helpful advice on data analysis
   and Dr Nicholas Katsanis for insightful discussion.
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   ANDREASEN NC, 1993, AM J PSYCHIAT, V150, P130
   Aylward EH, 1999, NEUROLOGY, V53, P2145
   Barnea-Goraly N, 2005, CEREB CORTEX, V15, P1848, DOI 10.1093/cercor/bhi062
   Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
   Buckner RL, 2004, NEUROIMAGE, V23, P724, DOI 10.1016/j.neuroimage.2004.06.018
   Chaste P, 2013, BIOL PSYCHIAT, V74, P576, DOI 10.1016/j.biopsych.2013.04.018
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Crepel A, 2011, AM J MED GENET B, V156B, P243, DOI 10.1002/ajmg.b.31163
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
   DAVIS PJM, 1977, NEUROPATH APPL NEURO, V3, P341, DOI 10.1111/j.1365-2990.1977.tb00595.x
   Fischl B, 2002, NEURON, V33, P341, DOI 10.1016/S0896-6273(02)00569-X
   Fischl B, 2012, NEUROIMAGE, V62, P774, DOI 10.1016/j.neuroimage.2012.01.021
   Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
   Fotenos AF, 2005, NEUROLOGY, V64, P1032
   Golzio C, 2013, CURR OPIN GENET DEV, V23, P240, DOI 10.1016/j.gde.2013.04.013
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Gripp KW, 2011, AM J MED GENET A, V155A, P706, DOI 10.1002/ajmg.a.33884
   Gripp KW, 2010, AM J MED GENET A, V152A, P1161, DOI 10.1002/ajmg.a.33391
   Hansen DV, 2010, NATURE, V464, P554, DOI 10.1038/nature08845
   Hanson E, 2014, BIOL PSYCHI IN PRESS
   Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
   Hardan AY, 2008, PSYCHIAT RES-NEUROIM, V163, P97, DOI 10.1016/j.pscychresns.2007.12.002
   Hardan AY, 2001, J CHILD NEUROL, V16, P421, DOI 10.1177/088307380101600607
   Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
   Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
   Hill J, 2010, P NATL ACAD SCI USA, V107, P13135, DOI 10.1073/pnas.1001229107
   Horev G, 2011, P NATL ACAD SCI USA, V108, P17076, DOI 10.1073/pnas.1114042108
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Lainhart JE, 1997, J AM ACAD CHILD PSY, V36, P282, DOI 10.1097/00004583-199702000-00019
   Lui JH, 2011, CELL, V146, P18, DOI 10.1016/j.cell.2011.06.030
   Matsuzawa J, 2001, CEREB CORTEX, V11, P335, DOI 10.1093/cercor/11.4.335
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Moreno-De-Luca A, 2013, LANCET NEUROL, V12, P406, DOI 10.1016/S1474-4422(13)70011-5
   Owen JP, 2014, J NEUROSCI, V34, P6214, DOI 10.1523/JNEUROSCI.4495-13.2014
   Palmen SJMC, 2005, PSYCHOL MED, V35, P561, DOI 10.1017/S0033291704003496
   Panizzon MS, 2009, CEREB CORTEX, V19, P2728, DOI 10.1093/cercor/bhp026
   Perrin JS, 2008, J NEUROSCI, V28, P9519, DOI 10.1523/JNEUROSCI.1212-08.2008
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   PIVEN J, 1992, BIOL PSYCHIAT, V31, P491, DOI 10.1016/0006-3223(92)90260-7
   Portmann T, 2014, CELL REP, V7, P1077, DOI 10.1016/j.celrep.2014.03.036
   RAKIC P, 1988, SCIENCE, V241, P170, DOI 10.1126/science.3291116
   Raz N, 2005, CEREB CORTEX, V15, P1676, DOI 10.1093/cercor/bhi044
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   Reiss AL, 1996, BRAIN, V119, P1763, DOI 10.1093/brain/119.5.1763
   Rosenfeld JA, 2010, J NEURODEV DISORD, V2, P26, DOI 10.1007/s11689-009-9037-4
   Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
   Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
   Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   Simons VIP Consortium, 2012, NEURON, V73, P1063
   Sparks BF, 2002, NEUROLOGY, V59, P184
   Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076
   Stiles J, 2010, NEUROPSYCHOL REV, V20, P327, DOI 10.1007/s11065-010-9148-4
   van der Kouwe AJW, 2008, NEUROIMAGE, V40, P559, DOI 10.1016/j.neuroimage.2007.12.025
   Walsh KM, 2011, GENET MED, V13, P377, DOI 10.1097/GIM.0b013e3182076c0c
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Winkler AM, 2010, NEUROIMAGE, V53, P1135, DOI 10.1016/j.neuroimage.2009.12.028
   Zufferey F, 2012, J MED GENET, V49, P660, DOI 10.1136/jmedgenet-2012-101203
NR 63
TC 6
Z9 6
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 20
PY 2014
VL 34
IS 34
BP 11199
EP 11211
DI 10.1523/JNEUROSCI.1366-14.2014
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA AO4MI
UT WOS:000341312600005
PM 25143601
ER

PT J
AU Diehl, MM
   Romanski, LM
AF Diehl, Maria M.
   Romanski, Lizabeth M.
TI Responses of Prefrontal Multisensory Neurons to Mismatching Faces and
   Vocalizations
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE communication; faces; multisensory integration; prefrontal cortex;
   primate; vocalizations
ID AUTISM SPECTRUM DISORDERS; SUPERIOR TEMPORAL SULCUS; CROSS-MODAL
   INTEGRATION; AUDITORY-CORTEX; RHESUS-MONKEY; AUDIOVISUAL SPEECH;
   FRONTAL-CORTEX; FACIAL EXPRESSIONS; VISUAL INFORMATION; MACAQUE MONKEYS
AB Social communication relies on the integration of auditory and visual information, which are present in faces and vocalizations. Evidence suggests that the integration of information from multiple sources enhances perception compared with the processing of a unimodal stimulus. Our previous studies demonstrated that single neurons in the ventrolateral prefrontal cortex (VLPFC) of the rhesus monkey (Macaca mulatta) respond to and integrate conspecific vocalizations and their accompanying facial gestures. We were therefore interested in how VLPFC neurons respond differentially to matching (congruent) and mismatching (incongruent) faces and vocalizations. We recorded VLPFC neurons during the presentation of movies with congruent or incongruent species-specific facial gestures and vocalizations as well as their unimodal components. Recordings showed that while many VLPFC units are multisensory and respond to faces, vocalizations, or their combination, a subset of neurons showed a significant change in neuronal activity in response to incongruent versus congruent vocalization movies. Among these neurons, we typically observed incongruent suppression during the early stimulus period and incongruent enhancement during the late stimulus period. Incongruent-responsive VLPFC neurons were both bimodal and nonlinear multisensory, fostering their ability to respond to changes in either modality of a face-vocalization stimulus. These results demonstrate that ventral prefrontal neurons respond to changes in either modality of an audiovisual stimulus, which is important in identity processing and for the integration of multisensory communication information.
C1 [Diehl, Maria M.] Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA.
   [Romanski, Lizabeth M.] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
RP Romanski, LM (reprint author), Univ Rochester, Sch Med, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
EM Liz_romanski@urmc.rochester.edu
FU National Institutes of Health [DC004845]; Center for Navigation and
   Communication Sciences [(P30) DC 005409]; Center for Visual Sciences
   [(P30) EY001319]
FX This work was supported by the National Institutes of Health DC004845
   (L.M.R.), Center for Navigation and Communication Sciences (P30) DC
   005409, and Center for Visual Sciences (P30) EY001319. We thank Mark
   Diltz, Jaewon Hwang, John Housel, and Christopher Louie for technical
   assistance and Bethany Plakke for critical comments.
CR Akechi H, 2010, NEUROPSYCHOLOGIA, V48, P2841, DOI 10.1016/j.neuropsychologia.2010.05.026
   Barbas H, 1992, Adv Neurol, V57, P91
   Barraclough NE, 2005, J COGNITIVE NEUROSCI, V17, P377, DOI 10.1162/0898929053279586
   Calvert GA, 2001, CEREB CORTEX, V11, P1110, DOI 10.1093/cercor/11.12.1110
   Chandrasekaran C, 2013, P NATL ACAD SCI USA, V110, pE4668, DOI 10.1073/pnas.1312518110
   Charbonneau G, 2013, NEUROPSYCHOLOGIA, V51, P1002, DOI 10.1016/j.neuropsychologia.2013.02.009
   Collignon O, 2013, CORTEX, V49, P1704, DOI 10.1016/j.cortex.2012.06.001
   Dahl Christoph D, 2010, Front Integr Neurosci, V4, P10, DOI 10.3389/fnint.2010.00010
   Davies MS, 2011, BRAIN BEHAV, V1, P1, DOI 10.1002/brb3.6
   Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x
   de Gelder B, 2000, COGNITION EMOTION, V14, P289
   de Jong JJ, 2010, SCHIZOPHR RES, V122, P136, DOI 10.1016/j.schres.2010.04.010
   Eich TS, 2014, BIOL PSYCHIAT, V76, P146, DOI 10.1016/j.biopsych.2013.09.032
   Ghazanfar AA, 2005, J NEUROSCI, V25, P5004, DOI 10.1523/JNEUROSCI.0799-05.2005
   GOUZOULES S, 1984, ANIM BEHAV, V32, P182, DOI 10.1016/S0003-3472(84)80336-X
   Hackett TA, 1999, BRAIN RES, V817, P45, DOI 10.1016/S0006-8993(98)01182-2
   HAUSER MD, 1993, BEHAV ECOL, V4, P194, DOI 10.1093/beheco/4.3.194
   Hein G, 2007, J NEUROSCI, V27, P7881, DOI 10.1523/JNEUROSCI.1740-07.2007
   Homae F, 2002, NEUROIMAGE, V16, P883, DOI 10.1006/nimg.2002.1138
   Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
   Ishii-Takahashi A, 2013, NEUROIMAGE CLIN, V4, P53
   Jones JA, 2003, NEUROREPORT, V14, P1129, DOI 10.1097/01.wnr.0000074343.81633.2a
   Kayser C, 2010, CURR BIOL, V20, P19, DOI 10.1016/j.cub.2009.10.068
   Kreifelts B, 2007, NEUROIMAGE, V37, P1445, DOI 10.1016/j.neuroimage.2007.06.020
   Lakatos P, 2005, J NEUROPHYSIOL, V94, P1904, DOI 10.1152/jn.00263.2005
   Lakatos P, 2007, NEURON, V53, P279, DOI 10.1016/j.neuron.2006.12.011
   Lakatos P, 2009, NEURON, V64, P419, DOI 10.1016/j.neuron.2009.10.014
   Laurienti PJ, 2004, EXP BRAIN RES, V158, P405, DOI 10.1007/s00221-004-1913-2
   Lerner MD, 2013, DEV COGN NEUROS-NETH, V3, P11, DOI 10.1016/j.dcn.2012.08.005
   Marumo K, 2014, NEUROIMAGE, V85, P518, DOI 10.1016/j.neuroimage.2013.04.050
   MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0
   MEREDITH MA, 1986, BRAIN RES, V365, P350
   MEREDITH MA, 1983, SCIENCE, V221, P389, DOI 10.1126/science.6867718
   MEREDITH MA, 1987, J NEUROSCI, V7, P3215
   Miller LM, 2005, J NEUROSCI, V25, P5884, DOI 10.1523/JNEUROSCI.0896-05.2005
   Naumer MJ, 2009, CEREB CORTEX, V19, P1641, DOI 10.1093/cercor/bhn200
   Noppeney U, 2008, CEREB CORTEX, V18, P598, DOI 10.1093/cercor/bhm091
   Ojanen V, 2005, NEUROIMAGE, V25, P333, DOI 10.1016/j.neuroimage.2004.12.001
   OScalaidhe SP, 1997, SCIENCE, V278, P1135, DOI 10.1126/science.278.5340.1135
   Perrodin C, 2014, J NEUROSCI, V34, P2524, DOI 10.1523/JNEUROSCI.2805-13.2014
   Petrides M, 2002, EUR J NEUROSCI, V16, P291, DOI 10.1046/j.1460-9568.2001.02090.x
   PREUSS TM, 1991, J COMP NEUROL, V310, P507, DOI 10.1002/cne.903100404
   Romanski LM, 1999, NAT NEUROSCI, V2, P1131, DOI 10.1038/16056
   Romanski LM, 2005, J NEUROPHYSIOL, V93, P734, DOI 10.1152/jn.00675.2004
   Romanski LM, 2012, NEUROSCIENCE, V214, P36, DOI 10.1016/j.neuroscience.2012.03.025
   Romanski LM, 2012, P NATL ACAD SCI USA, V109, P10717, DOI 10.1073/pnas.1204335109
   Romanski LM, 2002, NAT NEUROSCI, V5, P15, DOI 10.1038/nn781
   Romanski LM, 1999, J COMP NEUROL, V403, P141, DOI 10.1002/(SICI)1096-9861(19990111)403:2<141::AID-CNE1>3.0.CO;2-V
   Schroeder CE, 2008, TRENDS COGN SCI, V12, P106, DOI 10.1016/j.tics.2008.01.002
   SELTZER B, 1989, J COMP NEUROL, V281, P97, DOI 10.1002/cne.902810108
   Shams L, 2008, TRENDS COGN SCI, V12, P411, DOI 10.1016/j.tics.2008.07.006
   Silverman LB, 2010, COGNITION, V115, P380, DOI 10.1016/j.cognition.2010.01.002
   Stein BE, 2008, NAT REV NEUROSCI, V9, P255, DOI 10.1038/nrn2331
   Stone DB, 2011, NEUROPSYCHOLOGIA, V49, P3178, DOI 10.1016/j.neuropsychologia.2011.07.017
   Sugihara T, 2006, J NEUROSCI, V26, P11138, DOI 10.1523/JNEUROSCI.3550-06.2006
   Tsao DY, 2008, NAT NEUROSCI, V11, P877, DOI 10.1038/nn.2158
   van Atteveldt NM, 2007, CEREB CORTEX, V17, P962, DOI 10.1093/cercor/bhl007
   Vroomen J, 2001, COGN AFFECT BEHAV NE, V1, P382, DOI 10.3758/CABN.1.4.382
   Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66
   Watson R, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00744
   WEBSTER MJ, 1994, CEREB CORTEX, V4, P470, DOI 10.1093/cercor/4.5.470
   WILSON FAW, 1993, SCIENCE, V260, P1955, DOI 10.1126/science.8316836
NR 62
TC 2
Z9 2
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 20
PY 2014
VL 34
IS 34
BP 11233
EP 11243
DI 10.1523/JNEUROSCI.5168-13.2014
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AO4MI
UT WOS:000341312600009
PM 25143605
ER

PT J
AU Demyanenko, GP
   Mohan, V
   Zhang, XY
   Brennaman, LH
   Dharbal, KES
   Tran, TS
   Manis, PB
   Maness, PF
AF Demyanenko, Galina P.
   Mohan, Vishwa
   Zhang, Xuying
   Brennaman, Leann H.
   Dharbal, Katherine E. S.
   Tran, Tracy S.
   Manis, Paul B.
   Maness, Patricia F.
TI Neural Cell Adhesion Molecule NrCAM Regulates Semaphorin 3F-Induced
   Dendritic Spine Remodeling
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE cell adhesion; cortical pyramidal neurons; NrCAM; semaphorin; spine
   morphogenesis; visual cortex
ID PRIMARY VISUAL-CORTEX; AUTISM SPECTRUM DISORDERS; NR-CAM; HOMOPHILIC
   INTERACTION; THALAMOCORTICAL AXONS; FUNCTIONAL PLASTICITY; ASSOCIATION
   ANALYSIS; MOUSE; EXPERIENCE; BRAIN
AB Neuron-glial related cell adhesion molecule (NrCAM) is a regulator of axon growth and repellent guidance, and has been implicated in autism spectrum disorders. Here a novel postsynaptic role for NrCAM in Semaphorin3F (Sema3F)-induced dendritic spine remodeling was identified in pyramidal neurons of the primary visual cortex (V1). NrCAM localized to dendritic spines of star pyramidal cells in postnatal V1, where it was coexpressed with Sema3F. NrCAM deletion in mice resulted in elevated spine densities on apical dendrites of star pyramidal cells at both postnatal and adult stages, and electron microscopy revealed increased numbers of asymmetric synapses in layer 4 of V1. Whole-cell recordings in cortical slices from NrCAM-null mice revealed increased frequency of mEPSCs in star pyramidal neurons. Recombinant Sema3F-Fc protein induced spine retraction on apical dendrites of wild-type, but not NrCAM-null cortical neurons in culture, while re-expression ofNrCAM rescued the spine retraction response. NrCAM formed a complex in brain with Sema3F receptor subunits Neuropilin-2 (Npn-2) and PlexinA3 (PlexA3) through an Npn-2-binding sequence (TARNER) in the extracellular Igl domain. A trans heterozygous genetic interaction test demonstrated that Sema3F and NrCAM pathways interacted in vivo to regulate spine density in star pyramidal neurons. These findings reveal NrCAM as a novel postnatal regulator of dendritic spine density in cortical pyramidal neurons, and an integral component of the Sema3F receptor complex. The results implicate NrCAM as a contributor to excitatory/inhibitory balance in neocortical circuits.
C1 [Demyanenko, Galina P.; Mohan, Vishwa; Zhang, Xuying; Brennaman, Leann H.; Dharbal, Katherine E. S.; Maness, Patricia F.] Univ N Carolina, Sch Med, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA.
   [Manis, Paul B.] Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
   [Manis, Paul B.] Univ N Carolina, Sch Med, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA.
   [Tran, Tracy S.] Rutgers State Univ, Dept Biol Sci, Newark, NJ 07102 USA.
RP Maness, PF (reprint author), Univ N Carolina, Sch Med, Dept Biochem & Biophys, Campus Box 7260, Chapel Hill, NC 27599 USA.
EM srclab@med.unc.edu
FU National Institutes of Health (NIH) [R21MH098138, R01MH101605]; Charles
   and Johanna Busch Biomedical Award; University of North Carolina (UNC)
   [NIH P30NS045892]
FX This work was supported by National Institutes of Health (NIH) grants
   R21MH098138 and R01MH101605 (P.F.M.) and R01DC009809 (P.B.M.), Charles
   and Johanna Busch Biomedical Award (T.S.T.), and NIH P30NS045892 for
   University of North Carolina (UNC) Neuroscience Research Center core
   support. We gratefully acknowledge Dirk Montag (Leibniz Institute for
   Neurobiology, Magdeburg, Germany) for the NrCAM plasmid, Takeshi Sakurai
   and Carol Mason (Columbia University) for probes, Alex Kolodkin and
   David Ginty for Sema3F mice and probes, and Ben Philpot and Thorfinn
   Riday (UNC Chapel Hill) for advice on monocular deprivation. We are also
   grateful to Sam George, Eli Darnell, Jasbir Dalal, Sneha Venkatramen,
   and Erin Moore for experimental assistance.
CR AHMED B, 1994, J COMP NEUROL, V341, P39, DOI 10.1002/cne.903410105
   Alvarez VA, 2007, ANNU REV NEUROSCI, V30, P79, DOI 10.1146/annurev.neuro.30.051606.094222
   Antonini A, 1999, J NEUROSCI, V19, P4388
   Bateman A, 1996, EMBO J, V15, P6050
   Binzegger T, 2004, J NEUROSCI, V24, P8441, DOI 10.1523/JNEUROSCI.1400-04.2004
   Bonora E, 2005, EUR J HUM GENET, V13, P198, DOI 10.1038/sj.ejhg.5201315
   Brooks-Kayal A, 2010, BRAIN DEV-JPN, V32, P731, DOI 10.1016/j.braindev.2010.04.010
   Castellani V, 2002, ADV EXP MED BIOL, V515, P91
   CHO KO, 1992, NEURON, V9, P929, DOI 10.1016/0896-6273(92)90245-9
   COLBERT MC, 1995, DEV DYNAM, V204, P1
   Coleman JE, 2010, J NEUROSCI, V30, P9670, DOI 10.1523/JNEUROSCI.1248-10.2010
   Coleman JE, 2009, NEUROSCIENCE, V161, P561, DOI 10.1016/j.neuroscience.2009.03.045
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Dai JX, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073000
   Davey F, 2005, J NEUROCHEM, V94, P1243, DOI 10.1111/j.1471-4159.2005.03271.x
   Demyanenko GP, 2010, NEUROSCIENCE, V165, P107, DOI 10.1016/j.neuroscience.2009.09.077
   Demyanenko GP, 2011, J NEUROSCI, V31, P1545, DOI 10.1523/JNEUROSCI.4467-10.2011
   Dirks P, 2006, EUR J NEUROSCI, V24, P25, DOI 10.1111/j.1460-9568.2006.04899.x
   Docherty SJ, 2010, GENES BRAIN BEHAV, V9, P234, DOI 10.1111/j.1601-183X.2009.00553.x
   Douglas RJ, 2007, CURR BIOL, V17, pR496, DOI 10.1016/j.cub.2007.04.024
   Espinosa JS, 2012, NEURON, V75, P230, DOI 10.1016/j.neuron.2012.06.009
   Falk J, 2005, NEURON, V48, P63, DOI 10.1016/j.neuron.2005.08.033
   Farzin F, 2008, VISION RES, V48, P1471, DOI 10.1016/j.visres.2008.03.019
   Franklin KBJ, 1997, MOUSE BRAIN STEREOTA, V1st
   Giger RJ, 1998, NEURON, V21, P1079, DOI 10.1016/S0896-6273(00)80625-X
   Gordon JA, 1996, J NEUROSCI, V16, P3274
   Gordon U, 2006, J NEUROSCI, V26, P12717, DOI 10.1523/JNEUROSCI.3502-06.2006
   Gouveia RM, 2008, J BIOL CHEM, V283, P28038, DOI 10.1074/jbc.M804991200
   Hayashi-Takagi Akiko, 2011, Commun Integr Biol, V4, P211, DOI 10.4161/cib.4.2.14492
   Holtmaat A, 2009, NAT REV NEUROSCI, V10, P647, DOI 10.1038/nrn2699
   HUTTENLOCHER PR, 1979, BRAIN RES, V163, P195
   Ishiguro H, 2014, ADDICT BIOL, V19, P343, DOI 10.1111/j.1369-1600.2012.00469.x
   Janssen BJC, 2012, NAT STRUCT MOL BIOL, V19, P1293, DOI 10.1038/nsmb.2416
   Jiang B, 2010, J NEUROSCI, V30, P14261, DOI 10.1523/JNEUROSCI.2979-10.2010
   Karube F, 2011, CEREB CORTEX, V21, P1443, DOI 10.1093/cercor/bhq232
   Kuwajima T, 2012, NEURON, V74, P676, DOI 10.1016/j.neuron.2012.03.025
   Li MS, 2010, BRAIN RES BULL, V81, P107, DOI 10.1016/j.brainresbull.2009.08.028
   Maffei A, 2006, NATURE, V443, P81, DOI 10.1038/nature05079
   Maness PF, 2007, NAT NEUROSCI, V10, P19, DOI 10.1038/nn1827
   Marui T, 2009, INT J NEUROPSYCHOPH, V12, P1, DOI 10.1017/S1461145708009127
   Mataga N, 2004, NEURON, V44, P1031, DOI 10.1016/j.neuron.2004.11.028
   Matsuoka RL, 2011, NATURE, V470, P259, DOI 10.1038/nature09675
   McCurry CL, 2010, NAT NEUROSCI, V13, P450, DOI 10.1038/nn.2508
   Melin M, 2006, NEUROPSYCHOBIOLOGY, V54, P64, DOI 10.1159/000096040
   Morita A, 2006, J NEUROSCI, V26, P2971, DOI 10.1523/JNEUROSCI.5453-05.2006
   Moy SS, 2009, BEHAV BRAIN RES, V205, P123, DOI 10.1016/j.bbr.2009.06.021
   Nahmani M, 2005, J COMP NEUROL, V484, P458, DOI 10.1002/cne.20505
   Oleszewski M, 2000, J BIOL CHEM, V275, P34478, DOI 10.1074/jbc.M004147200
   Olsen SR, 2012, NATURE, V483, P47, DOI 10.1038/nature10835
   Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
   Pellicano E, 2008, CURR BIOL, V18, pR748, DOI 10.1016/j.cub.2008.07.004
   Petanjek Z, 2011, P NATL ACAD SCI USA, V108, P13281, DOI 10.1073/pnas.1105108108
   PETERS A, 1970, AM J ANAT, V127, P321, DOI 10.1002/aja.1001270402
   Petralia RS, 2005, MOL CELL NEUROSCI, V29, P436, DOI 10.1016/j.mcn.2005.03.013
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Robbins EM, 2010, NEURON, V68, P894, DOI 10.1016/j.neuron.2010.11.003
   Robertson CE, 2013, J NEUROSCI, V 33, P16983, DOI 10.1523/JNEUROSCI.0448-13.2013
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Sahay A, 2003, J NEUROSCI, V23, P6671
   Sakurai T, 2001, J CELL BIOL, V154, P1259, DOI 10.1083/jcb.200104122
   Sakurai T, 2012, MOL CELL NEUROSCI, V49, P351, DOI 10.1016/j.mcn.2011.12.002
   Sakurai T, 2006, PSYCHIAT GENET, V16, P251, DOI 10.1097/01.ypg.0000242196.81891.c9
   Schlatter MC, 2008, J NEUROCHEM, V104, P731, DOI 10.1111/j.1471-4159.2007.05013.x
   Shi Y, 2009, J NEUROSCI, V29, P8129, DOI 10.1523/JNEUROSCI.4681-08.2009
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Stratford KJ, 1996, NATURE, V382, P258, DOI 10.1038/382258a0
   Sur M, 2013, PROG BRAIN RES, V207, P243, DOI 10.1016/B978-0-444-63327-9.00002-3
   Tran TS, 2007, ANNU REV CELL DEV BI, V23, P263, DOI 10.1146/annurev.cellbio.22.010605.093554
   Tran TS, 2009, NATURE, V462, P1065, DOI 10.1038/nature08628
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wei CH, 2012, EXP MOL MED, V44, P413, DOI 10.3858/emm.2012.44.7.050
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Williams SE, 2006, NEURON, V50, P535, DOI 10.1016/j.neuron.2006.03.037
   Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
   Wright AG, 2007, J NEUROSCI, V27, P13667, DOI 10.1523/JNEUROSCI.2888-07.2007
   Wu SP, 2007, AM J MED GENET B, V144B, P492, DOI 10.1002/ajmg.b.30495
   Yuste R, 2011, NEURON, V71, P772, DOI 10.1016/j.neuron.2011.07.024
   Zipursky SL, 2010, CELL, V143, P343, DOI 10.1016/j.cell.2010.10.009
NR 78
TC 0
Z9 0
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 20
PY 2014
VL 34
IS 34
BP 11274
EP 11287
DI 10.1523/JNEUROSCI.1774-14.2014
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA AO4MI
UT WOS:000341312600012
PM 25143608
ER

PT J
AU Matthes, M
   Preusse, M
   Zhang, JZ
   Schechter, J
   Mayer, D
   Lentes, B
   Theis, F
   Prakash, N
   Wurst, W
   Trumbach, D
AF Matthes, Michaela
   Preusse, Martin
   Zhang, Jingzhong
   Schechter, Julia
   Mayer, Daniela
   Lentes, Bernd
   Theis, Fabian
   Prakash, Nilima
   Wurst, Wolfgang
   Truembach, Dietrich
TI Mouse IDGenes: a reference database for genetic interactions in the
   developing mouse brain
SO DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
LA English
DT Article
ID DOPAMINE NEURON DEVELOPMENT; SEGMENT POLARITY NETWORK; BETA-CATENIN;
   EXPRESSION PATTERNS; HINDBRAIN MALFORMATIONS; SIGNALING PATHWAY; ISTHMIC
   ORGANIZER; WNT/BETA-CATENIN; SPINAL-CORD; CYCLIN D1
AB The study of developmental processes in the mouse and other vertebrates includes the understanding of patterning along the anterior-posterior, dorsal-ventral and medial-lateral axis. Specifically, neural development is also of great clinical relevance because several human neuropsychiatric disorders such as schizophrenia, autism disorders or drug addiction and also brain malformations are thought to have neurodevelopmental origins, i.e. pathogenesis initiates during childhood and adolescence. Impacts during early neurodevelopment might also predispose to late-onset neurodegenerative disorders, such as Parkinson's disease. The neural tube develops from its precursor tissue, the neural plate, in a patterning process that is determined by compartmentalization into morphogenetic units, the action of local signaling centers and a well-defined and locally restricted expression of genes and their interactions. While public databases provide gene expression data with spatio-temporal resolution, they usually neglect the genetic interactions that govern neural development. Here, we introduce Mouse IDGenes, a reference database for genetic interactions in the developing mouse brain. The database is highly curated and offers detailed information about gene expressions and the genetic interactions at the developing mid-/hindbrain boundary. To showcase the predictive power of interaction data, we infer new Wnt/beta-catenin target genes by machine learning and validate one of them experimentally. The database is updated regularly. Moreover, it can easily be extended by the research community. Mouse IDGenes will contribute as an important resource to the research on mouse brain development, not exclusively by offering data retrieval, but also by allowing data input.
C1 [Matthes, Michaela; Zhang, Jingzhong; Schechter, Julia; Mayer, Daniela; Lentes, Bernd; Prakash, Nilima; Wurst, Wolfgang; Truembach, Dietrich] German Res Ctr Environm Hlth, Inst Dev Genet, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
   [Matthes, Michaela] Tech Univ Munchen Weihenstephan, Lehrstuhl Genet, D-85354 Freising Weihenstephan, Germany.
   [Preusse, Martin] German Res Ctr Environm Hlth, Inst Diabet & Regenerat Res, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
   [Preusse, Martin; Theis, Fabian] German Res Ctr Environm Hlth, Inst Computat Biol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
   [Theis, Fabian] Tech Univ Munich, Zentrum Math, D-85747 Garching, Germany.
   [Wurst, Wolfgang; Truembach, Dietrich] Max Planck Inst Psychiat, D-80804 Munich, Germany.
   [Wurst, Wolfgang] Deutsch Zentrum Neurodegenerat Erkrankungen eV DZ, Standort Munchen, D-80336 Munich, Germany.
   [Wurst, Wolfgang] Tech Univ Munchen Weihenstephan, Helmholtz Zentrum Munchen, Lehrstuhl Entwicklungsgenet, D-85764 Neuherberg, Germany.
   [Wurst, Wolfgang] Univ Munich, Adolf Butenandt Inst, Munich Cluster Syst Neurol SyNergy, D-80336 Munich, Germany.
RP Trumbach, D (reprint author), German Res Ctr Environm Hlth, Inst Dev Genet, Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany.
EM nilima.prakash@helmholtz-muenchen.de; wurst@helmholtz-muenchen.de;
   dietrich.truembach@helmholtz-muenchen.de
FU EU [FP7-Health-F4-2010-242129]; 'Bundesministerium fur Bildung und
   Forschung' in the consortium 'From Disease Genes to Protein Pathways'
   [FKZ01GS0858]; Helmholtz Zentrum Munchen - Deutsches Forschungszentrum
   fur Gesundheit und Umwelt (HMGU); 'Deutsche Forschungsgemeinschaft'
   ('German Research Foundation') [EXC 1010]
FX The 'Deutsche Forschungsgemeinschaft' ('German Research Foundation')
   within the framework of the Munich Cluster for Systems Neurology EXC
   1010 SyNergy]; the EU grant 'Systems Biology of Stem Cells and
   Reprogramming' [FP7-Health-F4-2010-242129]; the 'Bundesministerium fur
   Bildung und Forschung' in the consortium 'From Disease Genes to Protein
   Pathways' [FKZ01GS0858]. Funding for open access charge: Helmholtz
   Zentrum Munchen - Deutsches Forschungszentrum fur Gesundheit und Umwelt
   (HMGU).
CR Aswani Anil, 2010, BMC Bioinformatics, V11, P413, DOI 10.1186/1471-2105-11-413
   Augustin R., 2011, INT J ALZHEIMERS DIS, V2011
   Bard JBL, 1998, MECH DEVELOP, V74, P111, DOI 10.1016/S0925-4773(98)00069-0
   Barkovich AJ, 2009, BRAIN, V132, P3199, DOI 10.1093/brain/awp247
   Braun MM, 2003, DEVELOPMENT, V130, P5579, DOI 10.1242/dev.00685
   Cartharius K, 2005, BIOINFORMATICS, V21, P2933, DOI 10.1093/bioinformatics/bti473
   Caspary T, 2003, NAT REV NEUROSCI, V4, P289, DOI 10.1038/nrn1073
   Chamorro MN, 2005, EMBO J, V24, P73, DOI 10.1038/sj.emboj.7600460
   Chatr-aryamontri A, 2013, NUCLEIC ACIDS RES, V41, pD816, DOI 10.1093/nar/gks1158
   Chenn A, 2002, SCIENCE, V297, P365, DOI 10.1126/science.1074192
   Christiansen JH, 2006, NUCLEIC ACIDS RES, V34, pD637, DOI 10.1093/nar/gkj006
   Chung S, 2009, CELL STEM CELL, V5, P646, DOI 10.1016/j.stem.2009.09.015
   Clevers H, 2012, CELL, V149, P1192, DOI 10.1016/j.cell.2012.05.012
   Cohen CD, 2006, P NATL ACAD SCI USA, V103, P5682, DOI 10.1073/pnas.0511257103
   Crespo-Enriquez I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039977
   Danielian PS, 1996, NATURE, V383, P332, DOI 10.1038/383332a0
   Doherty D, 2013, LANCET NEUROL, V12, P381, DOI 10.1016/S1474-4422(13)70024-3
   Dworkin S, 2013, CELL MOL LIFE SCI, V70, P3365, DOI 10.1007/s00018-012-1240-x
   Ellisor D, 2012, DEV BIOL, V372, P249, DOI 10.1016/j.ydbio.2012.09.019
   Filali M, 2002, J BIOL CHEM, V277, P33398, DOI 10.1074/jbc.M107977200
   Finger JH, 2011, NUCLEIC ACIDS RES, V39, pD835, DOI 10.1093/nar/gkq1132
   Franceschini A, 2013, NUCLEIC ACIDS RES, V41, pD808, DOI 10.1093/nar/gks1094
   Fujimura N, 2007, J BIOL CHEM, V282, P1225, DOI 10.1074/jbc.M605851200
   Guo C, 2007, DEVELOPMENT, V134, P317, DOI 10.1242/dev.02745
   Hajihosseini MK, 2002, MECH DEVELOP, V113, P79, DOI 10.1016/S0925-4773(01)00656-6
   Hayamizu TF, 2013, J BIOMED SEMANT, V4, DOI 10.1186/2041-1480-4-15
   His W, 1892, ARCH ANAT ENTWGESCH, V1892, P346
   Hock S, 2013, BMC SYST BIOL, V7, DOI 10.1186/1752-0509-7-48
   Hoekstra EJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053122
   Holloway Dustin T, 2005, Genome Inform, V16, P83
   Hovanes K, 2001, NAT GENET, V28, P53, DOI 10.1038/ng0501-53
   Jessell TM, 2000, NAT REV GENET, V1, P20, DOI 10.1038/35049541
   Joksimovic M, 2009, NAT NEUROSCI, V12, P125, DOI 10.1038/nn.2243
   Kerrien S, 2012, NUCLEIC ACIDS RES, V40, pD841, DOI 10.1093/nar/gkr1088
   Kobielak K, 1999, ACTA BIOCHIM POL, V46, P885
   Lee HY, 2004, SCIENCE, V303, P1020, DOI 10.1126/science.1091611
   Lee SMK, 1997, DEVELOPMENT, V124, P959
   Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453
   Li B, 2009, DEVELOPMENT, V136, P3267, DOI 10.1242/dev.036954
   Lin LZ, 2007, P NATL ACAD SCI USA, V104, P9313, DOI 10.1073/pnas.0700923104
   Ma WZ, 2006, MOL SYST BIOL, V2, DOI 10.1038/msb4100111
   Mastick GS, 1996, J COMP NEUROL, V374, P246
   Mathelier A, 2014, NUCLEIC ACIDS RES, V42, pD142, DOI 10.1093/nar/gkt997
   McGrew LL, 1999, MECH DEVELOP, V87, P21, DOI 10.1016/S0925-4773(99)00136-7
   MCMAHON AP, 1992, CELL, V69, P581, DOI 10.1016/0092-8674(92)90222-X
   Merlini L., 2013, J CHILD NEUROL, V29, P538
   Nakamura Rei E I, 2007, BMC Cell Biol, V8, P52, DOI 10.1186/1471-2121-8-52
   Nykter M, 2009, ANN NY ACAD SCI, V1158, P205, DOI 10.1111/j.1749-6632.2008.03758.x
   Omodei D, 2008, DEVELOPMENT, V135, P3459, DOI 10.1242/dev.027003
   Pollock JD, 2014, TRENDS NEUROSCI, V37, P106, DOI 10.1016/j.tins.2013.11.001
   Porter JD, 1997, DEV BRAIN RES, V100, P121, DOI 10.1016/S0165-3806(97)00020-5
   Prakash N, 2004, CELL TISSUE RES, V318, P5, DOI 10.1007/s00441-004-0955-x
   Prakash N, 2007, NEURODEGENER DIS, V4, P333, DOI 10.1159/000101891
   Prakash N, 2006, J PHYSIOL-LONDON, V575, P403, DOI 10.1113/jphysiol.2006.113464
   Puelles L, 2013, TRENDS NEUROSCI, V36, P570, DOI 10.1016/j.tins.2013.06.004
   Quandt K, 1995, NUCLEIC ACIDS RES, V23, P4878, DOI 10.1093/nar/23.23.4878
   Sato T, 2009, DEVELOPMENT, V136, P3617, DOI 10.1242/dev.041210
   Shtutman M, 1999, P NATL ACAD SCI USA, V96, P5522, DOI 10.1073/pnas.96.10.5522
   Siddiqui AS, 2005, P NATL ACAD SCI USA, V102, P18485, DOI 10.1073/pnas.0509455102
   Tetsu O, 1999, NATURE, V398, P422
   Trumbach D, 2010, BMC SYST BIOL, V4, DOI 10.1186/1752-0509-4-159
   Turning A.M., 1952, PHILOS T R SOC B, V237, P37, DOI DOI 10.1098/RSTB.1952.0012
   van Amerongen R, 2009, DEVELOPMENT, V136, P3205, DOI 10.1242/dev.033910
   Vieira C, 2010, INT J DEV BIOL, V54, P7, DOI 10.1387/ijdb.092853cv
   Visel A, 2004, NUCLEIC ACIDS RES, V32, pD552, DOI 10.1093/nar/gkh029
   von Dassow G, 2000, NATURE, V406, P188, DOI 10.1038/35018085
   Wittmann DM, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000569
   Wurst W, 2001, NAT REV NEUROSCI, V2, P99, DOI 10.1038/35053516
   Yang J, 2013, DEVELOPMENT, V140, P1342, DOI 10.1242/dev.080630
   Zhou X, 2007, BIOINFORMATICS, V23, P1106, DOI 10.1093/bioinformatics/btm036
NR 70
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1758-0463
J9 DATABASE-OXFORD
JI Database
PD AUG 20
PY 2014
AR bau083
DI 10.1093/database/bau083
PG 16
WC Mathematical & Computational Biology
SC Mathematical & Computational Biology
GA AN5KF
UT WOS:000340628900001
ER

PT J
AU Krawczyk, DC
   Kandalaft, MR
   Didehbani, N
   Allen, TT
   McClelland, MM
   Tamminga, CA
   Chapman, SB
AF Krawczyk, Daniel C.
   Kandalaft, Michelle R.
   Didehbani, Nyaz
   Allen, Tandra T.
   McClelland, M. Michelle
   Tamminga, Carol A.
   Chapman, Sandra B.
TI An investigation of reasoning by analogy in schizophrenia and autism
   spectrum disorder
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE analogy; reasoning; schizophrenia; autism spectrum disorder; distraction
ID HIGH-FUNCTIONING AUTISM; WORKING-MEMORY; PREFRONTAL CORTEX; RELATIONAL
   INTEGRATION; ASPERGERS SYNDROME; SOCIAL COGNITION; MORAL JUDGMENT;
   SIMILARITY; MIND; CHILDREN
AB Relational reasoning ability relies upon by both cognitive and social factors. We compared analogical reasoning performance in healthy controls (HC) to performance in individuals with Autism Spectrum Disorder (ASD), and individuals with schizophrenia (SZ). The experimental task required participants to find correspondences between drawings of scenes. Participants were asked to infer which item within one scene best matched a relational item within the second scene. We varied relational complexity, presence of distraction, and type of objects in the analogies (living or non-living items). We hypothesized that the cognitive differences present in SZ would reduce relational inferences relative to ASD and HC. We also hypothesized that both SZ and ASD would show lower performance on living item problems relative to HC due to lower social function scores. Overall accuracy was higher for HC relative to SZ, consistent with prior research. Across groups, higher relational complexity reduced analogical responding, as did the presence of non-living items. Separate group analyses revealed that the ASD group was less accurate at making relational inferences in problems that involved mainly non-living items and when distractors were present. The SZ group showed differences in problem type similar to the ASD group. Additionally, we found significant correlations between social cognitive ability and analogical reasoning, particularly for the SZ group. These results indicate that differences in cognitive and social abilities impact the ability to infer analogical correspondences along with numbers of relational elements and types of objects present in the problems.
C1 [Krawczyk, Daniel C.; Kandalaft, Michelle R.; Didehbani, Nyaz; Allen, Tandra T.; McClelland, M. Michelle; Chapman, Sandra B.] Univ Texas Dallas, Sch Behav & Brain Sci, Ctr BrainHlth, Dallas, TX 75235 USA.
   [Krawczyk, Daniel C.; Kandalaft, Michelle R.; Tamminga, Carol A.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
RP Krawczyk, DC (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci, Ctr BrainHlth, 2200 Mockingbird Lane, Dallas, TX 75235 USA.
EM daniel.krawczyk@utdallas.edu
FU Lattner Foundation; Crystal Charity Ball; Wacker Foundation
FX We thank Lindsey Richland for contributions to the development of the
   task. We also thank Greg Allen, Candace Mills, Mujeeb Shad, Mette
   Posamentier, Jim Bartlett, and John Hart for helpful comments and
   suggestions. We thank Anne Marie Preston, Cassandra Adams, and Karen
   Osborne for their contributions to the data collection and
   neuropsychological testing. This work was supported by funding from the
   Lattner Foundation, Crystal Charity Ball, and the Wacker Foundation.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Blackshaw AJ, 2001, AUTISM, V5, P147, DOI 10.1177/1362361301005002005
   BLAIR RJR, 1995, COGNITION, V57, P1, DOI 10.1016/0010-0277(95)00676-P
   BOWMAN EP, 1988, BRIT J PSYCHIAT, V152, P377, DOI 10.1192/bjp.152.3.377
   Brown A., 1989, COGNITION, V35, P69, DOI [DOI 10.1016/0010-0277(90)90037-K, 10.1016/0010-0277(90)90037-k]
   CHENG PW, 1985, COGNITIVE PSYCHOL, V17, P391, DOI 10.1016/0010-0285(85)90014-3
   Cho S, 2007, MEM COGNITION, V35, P1445, DOI 10.3758/BF03193614
   Chua HF, 2005, PERS SOC PSYCHOL B, V31, P925, DOI 10.1177/0146167204272166
   COSMIDES L, 1989, COGNITION, V31, P187, DOI 10.1016/0010-0277(89)90023-1
   Dickinson D, 2004, BIOL PSYCHIAT, V55, P826, DOI 10.1016/j.biopsych.2003.12.010
   Doody GA, 1998, PSYCHOL MED, V28, P397, DOI 10.1017/S003329179700648X
   ELLIOTT R, 1995, PSYCHOL MED, V25, P619
   Ermer E, 2010, PSYCHOL SCI, V21, P1399, DOI 10.1177/0956797610384148
   Frith CD, 1996, PSYCHOL MED, V26, P521
   GENTNER D, 1986, COGNITIVE SCI, V10, P277, DOI 10.1207/s15516709cog1003_2
   GENTNER D, 1983, COGNITIVE SCI, V7, P155, DOI 10.1207/s15516709cog0702_3
   Gentner D., 1991, PERSPECTIVES LANGUAG, P225
   GICK ML, 1983, COGNITIVE PSYCHOL, V15, P1, DOI 10.1016/0010-0285(83)90002-6
   Goel V, 2009, NEUROPSYCHOLOGIA, V47, P2790, DOI 10.1016/j.neuropsychologia.2009.06.002
   Goswami U, 2001, BRIT J PSYCHOL, V92, P257, DOI 10.1348/000712601162068
   Green MF, 2000, SCHIZOPHRENIA BULL, V26, P119
   HALFORD GS, 1994, CHILD DEV, V65, P1338, DOI 10.1111/j.1467-8624.1994.tb00820.x
   Hayashi M, 2008, BRAIN COGNITION, V66, P306, DOI 10.1016/j.bandc.2007.09.008
   Heinrichs RW, 1998, NEUROPSYCHOLOGY, V12, P426, DOI 10.1037/0894-4105.12.3.426
   Holyoak KJ, 1995, ANN NY ACAD SCI, V769, P253, DOI 10.1111/j.1749-6632.1995.tb38143.x
   Hummel JE, 1997, PSYCHOL REV, V104, P427, DOI 10.1037//0033-295X.104.3.427
   Hummel JE, 2003, PSYCHOL REV, V110, P220, DOI 10.1037/0033-295X.110.2.220
   Kotovsky L, 1996, CHILD DEV, V67, P2797, DOI 10.1111/j.1467-8624.1996.tb01889.x
   Krawczyk DC, 2012, BRAIN RES, V1428, P13, DOI 10.1016/j.brainres.2010.11.080
   Krawczyk DC, 2008, NEUROPSYCHOLOGIA, V46, P2020, DOI 10.1016/j.neuropsychologia.2008.02.001
   Krawczyk DC, 2005, COGNITIVE SCI, V29, P797, DOI 10.1207/s15516709cog0000_27
   Krawczyk DC, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00062
   Lai M. C., 2014, LANCET, V6736, P61539
   Langdon R, 2010, SCHIZOPHRENIA BULL, V36, P321, DOI 10.1093/schbul/sbn069
   Levin HS, 2005, PEDIATR NEUROL, V33, P79, DOI 10.1016/j.pediatneurol.2005.02.002
   LINK NF, 1977, CAN PSYCHIAT ASSOC J, V22, P341
   MARKMAN AB, 1993, COGNITIVE PSYCHOL, V25, P431, DOI 10.1006/cogp.1993.1011
   Matheson S, 2008, PSYCHIAT RES, V159, P207, DOI 10.1016/j.psychres.2007.04.006
   Morrison RG, 2004, J COGNITIVE NEUROSCI, V16, P260, DOI 10.1162/089892904322984553
   Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x
   Nuechterlein KH, 2004, SCHIZOPHR RES, V72, P29, DOI 10.1016/j.schres.2004.09.007
   Penn DC, 2008, BEHAV BRAIN SCI, V31, P109, DOI 10.1017/S0140525X08003543
   Pijnacker J, 2009, NEUROPSYCHOLOGIA, V47, P644, DOI 10.1016/j.neuropsychologia.2008.11.011
   Pijnacker J, 2009, J AUTISM DEV DISORD, V39, P607, DOI 10.1007/s10803-008-0661-8
   Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
   Raine A, 2006, SOC COGN AFFECT NEUR, V1, P203, DOI 10.1093/scan/nsl033
   Richland LE, 2006, J EXP CHILD PSYCHOL, V94, P249, DOI 10.1016/j.jecp.2006.02.002
   Sahyoun CP, 2009, J AUTISM DEV DISORD, V39, P1014, DOI 10.1007/s10803-009-0712-9
   Sasson NJ, 2011, J NEURODEV DISORD, V3, P87, DOI 10.1007/s11689-010-9068-x
   Shenhav A, 2014, J NEUROSCI, V34, P4741, DOI 10.1523/JNEUROSCI.3390-13.2014
   Simpson J, 2004, EUR PSYCHIAT, V19, P344, DOI 10.1016/j.eurpsy.2004.05.009
   Snyder PJ, 2008, PSYCHIAT RES, V160, P316, DOI 10.1016/j.psychres.2007.07.011
   Startup H, 2008, EUR PSYCHIAT, V23, P457, DOI 10.1016/j.eurpsy.2008.04.005
   Tamminga CA, 2010, AM J PSYCHIAT, V167, P1178, DOI 10.1176/appi.ajp.2010.09081187
   Tohill JM, 2000, THINK REASONING, V6, P27, DOI DOI 10.1080/135467800393911
   Vendetti M, 2012, COGN AFFECT BEHAV NE, V12, P804, DOI 10.3758/s13415-012-0103-0
   Viskontas IV, 2004, PSYCHOL AGING, V19, P581, DOI 10.1037/0882-7974.19.4.581
   Waltz JA, 1999, PSYCHOL SCI, V10, P119, DOI 10.1111/1467-9280.00118
   Waltz JA, 2000, MEM COGNITION, V28, P1205, DOI 10.3758/BF03211821
   Wharton CM, 1996, MEM COGNITION, V24, P629, DOI 10.3758/BF03201088
   WHARTON CM, 1994, COGNITIVE PSYCHOL, V26, P64, DOI 10.1006/cogp.1994.1003
   Ziv I, 2011, COGN NEUROPSYCHIATRY, V16, P71, DOI 10.1080/13546805.2010.492693
NR 63
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD AUG 20
PY 2014
VL 8
AR 517
DI 10.3389/fnhum.2014.00517
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AN6YY
UT WOS:000340746100001
PM 25191240
ER

PT J
AU Germain, ND
   Chen, PF
   Plocik, AM
   Glatt-Deeley, H
   Brown, J
   Fink, JJ
   Bolduc, KA
   Robinson, TM
   Levine, ES
   Reiter, LT
   Graveley, BR
   Lalande, M
   Chamberlain, SJ
AF Germain, Noelle D.
   Chen, Pin-Fang
   Plocik, Alex M.
   Glatt-Deeley, Heather
   Brown, Judith
   Fink, James J.
   Bolduc, Kaitlyn A.
   Robinson, Tiwanna M.
   Levine, Eric S.
   Reiter, Lawrence T.
   Graveley, Brenton R.
   Lalande, Marc
   Chamberlain, Stormy J.
TI Gene expression analysis of human induced pluripotent stem cell-derived
   neurons carrying copy number variants of chromosome 15q11-q13.1
SO MOLECULAR AUTISM
LA English
DT Article
DE UBE3A; autism; induced pluripotent stem cells; 15q duplication; Angelman
   syndrome
ID METHYLATION-SPECIFIC PCR; ANGELMAN SYNDROME; PRADER-WILLI; 15Q
   DUPLICATION; HUMAN GENOME; AUTISM; PROTEIN; MITHRAMYCIN; BRAIN;
   TRANSCRIPTION
AB Background: Duplications of the chromosome 15q11-q13.1 region are associated with an estimated 1 to 3% of all autism cases, making this copy number variation (CNV) one of the most frequent chromosome abnormalities associated with autism spectrum disorder (ASD). Several genes located within the 15q11-q13.1 duplication region including ubiquitin protein ligase E3A (UBE3A), the gene disrupted in Angelman syndrome (AS), are involved in neural function and may play important roles in the neurobehavioral phenotypes associated with chromosome 15q11-q13.1 duplication (Dup15q) syndrome.
   Methods: We have generated induced pluripotent stem cell (iPSC) lines from five different individuals containing CNVs of 15q11-q13.1. The iPSC lines were differentiated into mature, functional neurons. Gene expression across the 15q11-q13.1 locus was compared among the five iPSC lines and corresponding iPSC-derived neurons using quantitative reverse transcription PCR (qRT-PCR). Genome-wide gene expression was compared between neurons derived from three iPSC lines using mRNA-Seq.
   Results: Analysis of 15q11-q13.1 gene expression in neurons derived from Dup15q iPSCs reveals that gene copy number does not consistently predict expression levels in cells with interstitial duplications of 15q11-q13.1. mRNA-Seq experiments show that there is substantial overlap in the genes differentially expressed between 15q11-q13.1 deletion and duplication neurons, Finally, we demonstrate that UBE3A transcripts can be pharmacologically rescued to normal levels in iPSC-derived neurons with a 15q11-q13.1 duplication.
   Conclusions: Chromatin structure may influence gene expression across the 15q11-q13.1 region in neurons. Genome-wide analyses suggest that common neuronal pathways may be disrupted in both the Angelman and Dup15q syndromes. These data demonstrate that our disease-specific stem cell models provide a new tool to decipher the underlying cellular and genetic disease mechanisms of ASD and may also offer a pathway to novel therapeutic intervention in Dup15q syndrome.
C1 [Germain, Noelle D.; Chen, Pin-Fang; Plocik, Alex M.; Glatt-Deeley, Heather; Graveley, Brenton R.; Lalande, Marc; Chamberlain, Stormy J.] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06032 USA.
   [Brown, Judith] Univ Connecticut, Dept Mol & Cell Biol, Chromosome Core, Storrs, CT 06269 USA.
   [Brown, Judith] Univ Connecticut, Dept Allied Hlth Sci, Storrs, CT 06269 USA.
   [Fink, James J.; Bolduc, Kaitlyn A.; Robinson, Tiwanna M.; Levine, Eric S.] Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington, CT 06030 USA.
   [Reiter, Lawrence T.] Univ Tennessee, Hlth Sci Ctr, Dept Neurol, Memphis, TN 38163 USA.
   [Graveley, Brenton R.] Univ Connecticut, Inst Syst Genom, Farmington, CT 06030 USA.
RP Chamberlain, SJ (reprint author), Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, 400 Farmington Ave, Farmington, CT 06032 USA.
EM chamberlain@uchc.edu
FU NIH/NICHD [5R01HD068730-02]; Raymond and Beverly Sackler Foundation;
   Prutting fund; Autism Speaks
FX The authors would like to thank the members of the Chamberlain, Lalande,
   Graveley, and Levine labs for helpful discussions. This work was funded
   by NIH/NICHD grant 5R01HD068730-02 (S.J.C), the Raymond and Beverly
   Sackler Foundation (S.J.C), the Prutting fund (M.L.), and Autism Speaks
   (E.S.L.).
CR Andrusiak MG, 2012, J NEUROSCI, V32, P14809, DOI 10.1523/JNEUROSCI.1912-12.2012
   Baron CA, 2006, HUM MOL GENET, V15, P853, DOI 10.1093/hmg/ddl004
   BLUME SW, 1991, J CLIN INVEST, V88, P1613, DOI 10.1172/JCI115474
   BROWN JH, 1965, NEW ENGL J MED, V272, P111, DOI 10.1056/NEJM196501212720301
   Chamberlain SJ, 2001, GENOMICS, V73, P316, DOI 10.1006/geno.2001.6543
   Chamberlain SJ, 2010, P NATL ACAD SCI USA, V107, P17668, DOI 10.1073/pnas.1004487107
   Cook EH, 1997, AM J HUM GENET, V60, P928
   Germain ND, 2013, STEM CELLS DEV, V22, P1477, DOI 10.1089/scd.2012.0264
   Goytain A, 2007, J BIOL CHEM, V282, P8060, DOI 10.1074/jbc.M610314200
   He Y, 2008, J NEUROCHEM, V106, P1493, DOI 10.1111/j.1471-4159.2008.05486.x
   Herman JG, 1996, P NATL ACAD SCI USA, V93, P9821, DOI 10.1073/pnas.93.18.9821
   Herrup K, 2007, NAT REV NEUROSCI, V8, P368, DOI 10.1038/nrn2124
   Herzing LBK, 2002, HUM MOL GENET, V11, P1707, DOI 10.1093/hmg/11.15.1707
   Hogart A, 2008, HUM GENET, V124, P235, DOI 10.1007/s00439-008-0546-0
   Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
   Jima DD, 2010, BLOOD, V116, pE118, DOI 10.1182/blood-2010-05-285403
   Johnson MA, 2007, J NEUROSCI, V27, P3069, DOI 10.1523/JNEUROSCI.4562-06.2007
   Kayashima T, 2003, J HUM GENET, V48, P492, DOI 10.1007/s10038-003-0061-z
   KENNEDY B. J., 1965, CANCER CHEMO THERAP REP, V48, P59
   Kent WJ, 2002, GENOME RES, V12, P996, DOI 10.1101/gr.229102
   Kishino T, 1997, NAT GENET, V15, P70, DOI 10.1038/ng0197-70
   Kleinjan DA, 2005, AM J HUM GENET, V76, P8, DOI 10.1086/426833
   Koochek M, 2006, CLIN GENET, V69, P124, DOI 10.1111/j.1399-0004.2005.00560.x
   Kosaki K, 1997, AM J MED GENET, V73, P308
   Kuhnle S, 2011, J BIOL CHEM, V286, P19410, DOI 10.1074/jbc.M110.205211
   Langmead B, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-3-r25
   Lee SY, 2013, CELL MOL LIFE SCI, V71, P2747
   Lieberman R, 2012, ALCOHOL CLIN EXP RES, V36, P1678, DOI 10.1111/j.1530-0277.2012.01792.x
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Martins-Taylor K, 2013, HUM MOL GENET, V23, P2364
   Matsuura T, 1997, NAT GENET, V15, P74, DOI 10.1038/ng0197-74
   Meguro-Horike M, 2011, HUM MOL GENET, V20, P3798, DOI 10.1093/hmg/ddr298
   MILLER DM, 1987, AM J MED SCI, V294, P388, DOI 10.1097/00000441-198711000-00015
   Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
   Pankratz MT, 2007, STEM CELLS, V25, P1511, DOI 10.1634/stemcells.2006-0707
   Phillips-Cremins JE, 2013, CELL, V153, P1281, DOI 10.1016/j.cell.2013.04.053
   Rougeulle C, 1997, NAT GENET, V17, P14, DOI 10.1038/ng0997-14
   Schenck A, 2001, P NATL ACAD SCI USA, V98, P8844, DOI 10.1073/pnas.151231598
   Schroer RJ, 1998, AM J MED GENET, V76, P327, DOI 10.1002/(SICI)1096-8628(19980401)76:4<327::AID-AJMG8>3.0.CO;2-M
   Scoles HA, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-19
   SINGER FR, 1970, NEW ENGL J MED, V283, P634, DOI 10.1056/NEJM197009172831206
   Sleiman SF, 2011, J NEUROSCI, V31, P6858, DOI 10.1523/JNEUROSCI.0710-11.2011
   Smibert P, 2012, CELL REP, V1, P277, DOI 10.1016/j.celrep.2012.01.001
   Smith SE, 2011, SCI TRANSL MED, V3
   Sommer CA, 2009, STEM CELLS, V27, P543, DOI 10.1634/stemcells.2008-1075
   Svenstrup K, 2011, EUR J NEUROL, V18, P1197, DOI 10.1111/j.1468-1331.2011.03359.x
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
   Thomas MJ, 1999, GENE, V236, P197, DOI 10.1016/S0378-1119(99)00261-9
   Trapnell C, 2012, NAT PROTOC, V7, P562, DOI 10.1038/nprot.2012.016
   Trillingsgaard A, 2004, AUTISM, V8, P163, DOI 10.1177/1362361304042720
   Urraca N, 2013, AUTISM RES, V6, P268, DOI 10.1002/aur.1284
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757
NR 54
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD AUG 20
PY 2014
VL 5
AR 44
DI 10.1186/2040-2392-5-44
PG 19
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AO2NB
UT WOS:000341159400001
PM 25694803
ER

PT J
AU Gogolla, N
   Takesian, AE
   Feng, G
   Fagiolini, M
   Hensch, TK
AF Gogolla, Nadine
   Takesian, Anne E.
   Feng, Guoping
   Fagiolini, Michela
   Hensch, Takao K.
TI Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit
   Maturation
SO NEURON
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; PLUS TF/J MICE; CRITICAL-PERIOD;
   VISUAL-CORTEX; MULTISENSORY INTEGRATION; GASTROINTESTINAL PROBLEMS;
   FUNCTIONAL CONNECTIVITY; NEURAL SYSTEMS; AUDITORY FIELD; MUTANT MICE
AB Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+tf/J mouse model of idiopathic autism. The deficit reflected weakened gamma-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like schizophrenia and autism.
C1 [Gogolla, Nadine; Hensch, Takao K.] Harvard Univ, Dept Mol & Cellular Biol, Ctr Brain Sci, Cambridge, MA 02138 USA.
   [Takesian, Anne E.; Fagiolini, Michela; Hensch, Takao K.] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Neurol,FM Kirby Neurobiol Ctr, Boston, MA 02115 USA.
   [Takesian, Anne E.; Hensch, Takao K.] Canadian Inst Adv Res, Toronto, ON M5G 1Z8, Canada.
   [Feng, Guoping] MIT, McGovern Inst Brain Res, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
RP Hensch, TK (reprint author), Harvard Univ, Dept Mol & Cellular Biol, Ctr Brain Sci, 52 Oxford St, Cambridge, MA 02138 USA.
EM hensch@mcb.harvard.edu
FU National Institute of General Medical Sciences (NIGMS) [DP1OD003699];
   National Institute of Mental Health (NIMH) [1P50MH094271]; Human
   Frontier Science Program (HFSP); Charles King Trust/Charles Hood
   Foundation; Nancy Lurie Marks Foundation
FX We thank M. Nakamura for animal care, M. Ho for help with behavioral
   tests and T. K. H. laboratory members for feedback and discussion.
   Funded by the National Institute of General Medical Sciences (NIGMS)
   (DP1OD003699 to T. K. H.) and the National Institute of Mental Health
   (NIMH) (1P50MH094271 to T. K. H.), as well as postdoctoral fellowships
   from the Human Frontier Science Program (HFSP) and Charles King
   Trust/Charles Hood Foundation (to N.G.) and the Nancy Lurie Marks
   Foundation (to A.E.T.).
CR Ackermann H, 2010, BRAIN STRUCT FUNCT, V214, P419, DOI 10.1007/s00429-010-0257-x
   Allen JS, 2008, J NEUROSCI, V28, P11900, DOI 10.1523/JNEUROSCI.3141-08.2008
   Augustine JR, 1996, BRAIN RES REV, V22, P229, DOI 10.1016/S0165-0173(96)00011-2
   Babineau BA, 2013, PHYSIOL BEHAV, V114, P49, DOI 10.1016/j.physbeh.2013.03.006
   Barkat TR, 2011, NAT NEUROSCI, V14, P1189, DOI 10.1038/nn.2882
   Bernhardt BC, 2012, ANNU REV NEUROSCI, V35, P1, DOI 10.1146/annurev-neuro-062111-150536
   Brandwein AB, 2011, CEREB CORTEX, V21, P1042, DOI 10.1093/cercor/bhq170
   Caruana F, 2011, CURR BIOL, V21, P195, DOI 10.1016/j.cub.2010.12.042
   Cascio CJ, 2012, AUTISM, V16, P406, DOI 10.1177/1362361311430404
   Chaidez V, 2014, J AUTISM DEV DISORD, V44, P1117, DOI 10.1007/s10803-013-1973-x
   Chattopadhyaya B, 2007, NEURON, V54, P889, DOI 10.1016/j.neuron.2007.05.015
   Christianson JP, 2008, J NEUROSCI, V28, P13703, DOI 10.1523/JNEUROSCI.4270-08.2008
   Collignon O, 2013, CORTEX, V49, P1704, DOI 10.1016/j.cortex.2012.06.001
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
   Critchley HD, 2004, NAT NEUROSCI, V7, P189, DOI 10.1038/nn1176
   Defensor EB, 2011, BEHAV BRAIN RES, V217, P302, DOI 10.1016/j.bbr.2010.10.033
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Di Martino A, 2009, AM J PSYCHIAT, V166, P891, DOI 10.1176/appi.ajp.2009.08121894
   Doyle-Thomas KAR, 2013, J CHILD NEUROL, V28, P729, DOI 10.1177/0883073812451496
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Durand S, 2012, NEURON, V76, P1078, DOI 10.1016/j.neuron.2012.12.004
   Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
   Ellegood J., 2013, US SOC NEUR ABSTR
   Engen HG, 2013, CURR OPIN NEUROBIOL, V23, P275, DOI 10.1016/j.conb.2012.11.003
   Fagiolini M, 2000, NATURE, V404, P183
   Gick B, 2009, NATURE, V462, P502, DOI 10.1038/nature08572
   Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
   HABIB M, 1995, NEUROPSYCHOLOGIA, V33, P327, DOI 10.1016/0028-3932(94)00108-2
   Han K, 2013, NATURE, V503, P72, DOI 10.1038/nature12630
   Han S, 2014, NEURON, V81, P1282, DOI 10.1016/j.neuron.2014.01.016
   Han S, 2012, NATURE, V489, P385, DOI 10.1038/nature11356
   Hensch TK, 2004, SCIENCE, V303, P1678, DOI 10.1126/science.1091031
   Hensch TK, 2005, NAT REV NEUROSCI, V6, P877, DOI 10.1038/nrn1787
   Hermans EJ, 2011, SCIENCE, V334, P1151, DOI 10.1126/science.1209603
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Iwai Y, 2003, J NEUROSCI, V23, P6695
   Jackson SR, 2011, COGN NEUROSCI-UK, V2, P227, DOI 10.1080/17588928.2011.604717
   Kouser M, 2013, J NEUROSCI, V33, P18448, DOI 10.1523/JNEUROSCI.3017-13.2013
   Kurth F, 2010, BRAIN STRUCT FUNCT, V214, P519, DOI 10.1007/s00429-010-0255-z
   Lamm C, 2010, BRAIN STRUCT FUNCT, V214, P579, DOI 10.1007/s00429-010-0251-3
   Lerner A, 2009, CEREB CORTEX, V19, P218, DOI 10.1093/cercor/bhn074
   Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
   McElhanon B.O., 2014, PEDIATRICS IN PRESS
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   Megnin O, 2012, AUTISM RES, V5, P39, DOI 10.1002/aur.231
   Menon V, 2010, BRAIN STRUCT FUNCT, V214, P655, DOI 10.1007/s00429-010-0262-0
   Moretti P, 2006, CURR OPIN GENET DEV, V16, P276, DOI 10.1016/j.gde.2006.04.009
   Nieuwenhuys R, 2012, PROG BRAIN RES, V195, P123, DOI 10.1016/B978-0-444-53860-4.00007-6
   Olcese U, 2013, NEURON, V79, P579, DOI 10.1016/j.neuron.2013.06.010
   ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170
   Onore CE, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00158
   PANKSEPP J, 1981, DEV PSYCHOBIOL, V14, P327, DOI 10.1002/dev.420140405
   Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Remedios R, 2009, J NEUROSCI, V29, P1034, DOI 10.1523/JNEUROSCI.4089-08.2009
   Rodgers KM, 2008, CEREB CORTEX, V18, P2941, DOI 10.1093/cercor/bhn054
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Russo N, 2010, AUTISM RES, V3, P253, DOI 10.1002/aur.152
   Sawatari H, 2011, EUR J NEUROSCI, V34, P1944, DOI 10.1111/j.1460-9568.2011.07926.x
   Scattoni ML, 2011, GENES BRAIN BEHAV, V10, P44, DOI 10.1111/j.1601-183X.2010.00623.x
   Shibuki K, 2003, J PHYSIOL-LONDON, V549, P919, DOI 10.1113/jphysiol.2003.040709
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Takemoto M, 2014, J COMP NEUROL, V522, P1373, DOI 10.1002/cne.23491
   Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002
   von dem Hagen EAH, 2013, SOC COGN AFFECT NEUR, V8, P694, DOI 10.1093/scan/nss053
   Wallace MT, 2006, J NEUROSCI, V26, P11844, DOI 10.1523/JNEUROSCI.3295-06.2006
   Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
   Wylie KP, 2010, SCHIZOPHR RES, V123, P93, DOI 10.1016/j.schres.2010.08.027
   Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
NR 70
TC 10
Z9 10
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD AUG 20
PY 2014
VL 83
IS 4
BP 894
EP 905
DI 10.1016/j.neuron.2014.06.033
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA AN3ID
UT WOS:000340479600016
PM 25088363
ER

PT J
AU Clark, CM
   Chiu, CG
   Diaz, RL
   Goghari, VM
AF Clark, Cameron M.
   Chiu, Carina G.
   Diaz, Ruth L.
   Goghari, Vina M.
TI Intact anger recognition in depression despite aberrant visual facial
   information usage
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Anxiety; Anger; Emotion recognition; Bubbles task
ID MAJOR DEPRESSION; EMOTION PERCEPTION; AMYGDALA DAMAGE; EXPRESSION;
   DISORDER; SCHIZOPHRENIA; BUBBLES; MEMORY; DEFICITS; ANXIETY
AB Background: Previous literature has indicated abnormalities in facial emotion recognition abilities, as well as deficits in basic visual processes in major depression. However, the literature is unclear on a number of important factors including whether or not these abnormalities represent deficient or enhanced emotion recognition abilities compared to control populations, and the degree to which basic visual deficits might impact this process.
   Methods: The present study investigated emotion recognition abilities for angry versus neutral facial expressions in a sample of undergraduate students with Beck Depression Inventory-II (BDI-II) scores indicative of moderate depression (i.e. >= 20), compared to matched low-BDI-II score (i.e. <= 2) controls via the Bubbles Facial Emotion Perception Task.
   Results: Results indicated unimpaired behavioural performance in discriminating angry from neutral expressions in the high depressive symptoms group relative to the minimal depressive symptoms group, despite evidence of an abnormal pattern of visual facial information usage.
   Limitations: The generalizability of the current findings is limited by the highly structured nature of the facial emotion recognition task used, as well as the use of an analog sample undergraduates scoring high in self-rated symptoms of depression rather than a clinical sample.
   Conclusions: Our findings suggest that basic visual processes are involved in emotion recognition abnormalities in depression, demonstrating consistency with the emotion recognition literature in other psychopathologies (e.g. schizophrenia, autism, social anxiety). Future research should seek to replicate these findings in clinical populations with major depression, and assess the association between aberrant face gaze behaviours and symptom severity and social functioning. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Clark, Cameron M.; Chiu, Carina G.; Diaz, Ruth L.; Goghari, Vina M.] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Goghari, VM (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM vmgoghar@ucalgary.ca
FU Canadian Institutes of Health Research; University of Calgary;
   University Research Grant Committee; Canada Vanier Graduate Scholarship;
   Alberta Innovates Health Solutions studentship; Canadian Institutes of
   Health Research New Investigator Award
FX We thank Frederic Gosselin for sharing his Bubbles task with our
   research group. Data collection was supported by a Canadian Institutes
   of Health Research operating grant, a University of Calgary Seed Grant,
   and a University Research Grant Committee Starter Grant. Cameron M.
   Clark was supported by a Canada Vanier Graduate Scholarship, as well as
   an Alberta Innovates Health Solutions studentship. Vina Goghari was
   supported by a Canadian Institutes of Health Research New Investigator
   Award.
CR Adolphs R, 2002, CURR OPIN NEUROBIOL, V12, P169, DOI 10.1016/S0959-4388(02)00301-X
   Adolphs R, 2005, NATURE, V433, P68, DOI 10.1038/nature03086
   Anderson AK, 2000, NEUROPSYCHOLOGY, V14, P526, DOI 10.1037//0894-4105.14.4.526
   ARCHER J, 1992, BRIT J CLIN PSYCHOL, V31, P45
   Asthana HS, 1998, J AFFECT DISORDERS, V48, P57, DOI 10.1016/S0165-0327(97)00140-7
   Beck A.T., 1996, MANUAL BECK DEPRESSI
   Bouhuys AL, 1999, J NERV MENT DIS, V187, P595, DOI 10.1097/00005053-199910000-00002
   Bouhuys AL, 1996, PSYCHIAT RES, V64, P193, DOI 10.1016/S0165-1781(96)02930-7
   Bourke C, 2010, AUST NZ J PSYCHIAT, V44, P681, DOI 10.3109/00048674.2010.496359
   Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
   BRAND AN, 1992, J AFFECT DISORDERS, V25, P77, DOI 10.1016/0165-0327(92)90095-N
   Bubl E, 2009, WORLD J BIOL PSYCHIA, V10, P377, DOI 10.3109/15622970701513756
   Bubl E, 2012, BRIT J PSYCHIAT, V201, P151, DOI 10.1192/bjp.bp.111.100560
   Bubl E, 2010, BIOL PSYCHIAT, V68, P205, DOI 10.1016/j.biopsych.2010.02.009
   Chauvin A, 2005, J VISION, V5, P659, DOI 10.1167/5.9.1
   Clark CM, 2013, J ABNORM PSYCHOL, V122, P513, DOI 10.1037/a0031944
   DALGLEISH T, 1990, CLIN PSYCHOL REV, V10, P589, DOI 10.1016/0272-7358(90)90098-U
   Demenescu LR, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015058
   Douglas KM, 2011, BRIT J PSYCHIAT, V198, P115, DOI 10.1192/bjp.bp.110.080713
   GAEBEL W, 1992, EUR ARCH PSY CLIN N, V242, P46, DOI 10.1007/BF02190342
   GESSLER S, 1989, BRIT J CLIN PSYCHOL, V28, P19
   Gosselin F, 2001, VISION RES, V41, P2261, DOI 10.1016/S0042-6989(01)00097-9
   Harkness KL, 2005, COGNITION EMOTION, V19, P999, DOI 10.1080/02699930541000110
   Harkness KL, 2010, COGNITION EMOTION, V24, P497, DOI 10.1080/02699930902750249
   Kohler CG, 2011, PSYCHIAT RES, V188, P303, DOI 10.1016/j.psychres.2011.04.019
   Langenecker SA, 2005, J CLIN EXP NEUROPSYC, V27, P320, DOI 10.1080/13803390490490515720
   Langner O, 2009, PSYCHOL SCI, V20, P666, DOI 10.1111/j.1467-9280.2009.02357.x
   Lee JH, 2011, SCHIZOPHRENIA BULL, V37, P1001, DOI 10.1093/schbul/sbq006
   Leppanen JM, 2004, PSYCHIAT RES, V128, P123, DOI 10.1016/j.psychres.2004.05.020
   Longenecker S. A., 2007, PSYCHIAT RES, V152, P143
   Lundqvist D., 1998, KAROLINSKA DIRECTED
   MANDAL MK, 1985, PSYCHOL REP, V56, P653
   Mikhailova ES, 1996, BIOL PSYCHIAT, V40, P697, DOI 10.1016/0006-3223(96)00032-7
   Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366
   Ridout N, 2003, COGNITION EMOTION, V17, P101, DOI 10.1080/02699930143000626
   RUBINOW DR, 1992, BIOL PSYCHIAT, V31, P947, DOI 10.1016/0006-3223(92)90120-O
   Spezio ML, 2007, J NEUROSCI, V27, P3994, DOI 10.1523/JNEUROSCI.3789-06.2007
   Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027
   Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
   Spielberger C. D., 1983, MANUAL STATE TRAIT A
   Stuhrmann A., 2011, BIOL MOOD ANXIETY DI, V1, P1
   Suslow T, 2001, PERCEPT MOTOR SKILL, V92, P857, DOI 10.2466/PMS.92.3.857-868
   Wu L., 2012, DEPRESS RES TREAT, P1
   Zomet A, 2008, BIOL PSYCHIAT, V64, P667, DOI 10.1016/j.biopsych.2008.05.030
NR 44
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 20
PY 2014
VL 165
BP 196
EP 202
DI 10.1016/j.jad.2014.04.065
PG 7
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AJ7FF
UT WOS:000337861900031
PM 24882200
ER

PT J
AU Sundquist, J
   Sundquist, K
   Ji, JG
AF Sundquist, Jan
   Sundquist, Kristina
   Ji, Jianguang
TI Autism and attention-deficit/hyperactivity disorder among individuals
   with a family history of alcohol use disorders
SO ELIFE
LA English
DT Article
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; AGE; DISEASE; RISK; PREVALENCE;
   REGISTER; EXPOSURE; CHILDREN; TRENDS
AB Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36-1.58) and 2.70 (95% CI 2.59-2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.
C1 [Sundquist, Jan; Sundquist, Kristina; Ji, Jianguang] Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.
   [Sundquist, Jan; Sundquist, Kristina] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Stanford, CA USA.
RP Sundquist, J (reprint author), Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.
EM sundquist@med.lu.se; jianguang.ji@med.lu.se
RI Ji, Jianguang/E-9579-2011
OI Ji, Jianguang/0000-0003-0324-9496
FU Vetenskapsradet [2012-2378]; National Institute of Drug Abuse [R01
   DA030005]
FX Vetenskapsradet 2012-2378 Jan SundquistNational Institute of Drug Abuse
   R01 DA030005 Jan SundquistThe funders had no role in study design, data
   collection and interpretation, or the decision to submit the work for
   publication.
CR BERGER G, 1993, ALCOHOLISM FAMILY
   Biederman J, 2005, LANCET, V366, P237, DOI 10.1016/S0140-6736(05)66915-2
   Bishop S, 2007, J CHILD PSYCHOL PSYC, V48, P1111, DOI 10.1111/j.1469-7610.2007.01782.x
   Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
   Breslow NE, 1987, STAT METHODS CANC RE, VII
   Callaway E, 2012, NATURE, V488, P439, DOI 10.1038/488439a
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   dos Santos Silva I, 1999, CANC EPIDEMIOLOGY PR
   Ekbom A, 2011, METHODS MOL BIOL, V675, P215, DOI 10.1007/978-1-59745-423-0_10
   Esteve J, 1994, STAT METHODS CANC RE
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Golding J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009939
   Govorko D, 2012, BIOL PSYCHIAT, V72, P378, DOI 10.1016/j.biopsych.2012.04.006
   Gratten J, 2013, NAT GENET, V45, P234, DOI 10.1038/ng.2555
   Kinney DK, 2010, MED HYPOTHESES, V74, P102, DOI 10.1016/j.mehy.2009.07.052
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Landgren M, 2010, PEDIATRICS, V125, pE1178, DOI 10.1542/peds.2009-0712
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   LEWIS SJ, 2012, PLOS ONE, V8, DOI DOI 10.1371/J0URNAL.P0NE.0049407
   Ludvigsson JF, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-450
   Malaspina D, 2001, SCHIZOPHRENIA BULL, V27, P379
   NAROD SA, 1988, ENVIRON MOL MUTAGEN, V11, P401, DOI 10.1002/em.2850110311
   Nordenbaek C, 2014, EUR CHILD ADOLES PSY, V23, P35, DOI 10.1007/s00787-013-0419-5
   Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
   Parner ET, 2008, ARCH PEDIAT ADOL MED, V162, P1150, DOI 10.1001/archpedi.162.12.1150
   Rothman K, 1998, MODERN EPIDEMIOLOGY, V2nd
   Szpir M, 2006, ENVIRON HEALTH PERSP, V114, pA412
   Walsh CA, 2008, CELL, V135, P396, DOI 10.1016/j.cell.2008.10.015
   Yamauchi Y, 2012, J ANDROL, V33, P229, DOI 10.2164/jandrol.111.013532
   Zaidi S, 2013, NATURE, V498, P220, DOI 10.1038/nature12141
NR 30
TC 0
Z9 0
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD AUG 19
PY 2014
VL 3
AR e02917
DI 10.7554/eLife.02917
PG 8
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AO3RU
UT WOS:000341253500002
PM 25139954
ER

PT J
AU Takeuchi, H
   Taki, Y
   Sekiguchi, A
   Nouchi, R
   Kotozaki, Y
   Nakagawa, S
   Miyauchi, CM
   Iizuka, K
   Yokoyama, R
   Shinada, T
   Yamamoto, Y
   Hanawa, S
   Araki, T
   Hashizume, H
   Sassa, Y
   Kawashima, R
AF Takeuchi, Hikaru
   Taki, Yasuyuki
   Sekiguchi, Atsushi
   Nouchi, Rui
   Kotozaki, Yuka
   Nakagawa, Seishu
   Miyauchi, Carlos M.
   Iizuka, Kunio
   Yokoyama, Ryoichi
   Shinada, Takamitsu
   Yamamoto, Yuki
   Hanawa, Sugiko
   Araki, Tsuyoshi
   Hashizume, Hiroshi
   Sassa, Yuko
   Kawashima, Ryuta
TI Creativity measured by divergent thinking is associated with two axes of
   autistic characteristics
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE creativity; divergent thinking; empathizing; systemizing; D score;
   autistic characteristics
ID FALSE DISCOVERY RATE; VOXEL-BASED MORPHOMETRY; HIGH-FUNCTIONING AUTISM;
   WHITE-MATTER STRUCTURES; NORMAL SEX-DIFFERENCES; EMPATHY QUOTIENT EQ;
   SYSTEMATIZING QUOTIENT; ASPERGER-SYNDROME; EMOTIONAL INTELLIGENCE;
   EXECUTIVE FUNCTION
AB Creativity generally involves the conception of original and valuable ideas, and it plays a key role in scientific achievement. Moreover, individuals with autistic spectrum conditions (ASCs) tend to achieve in scientific fields. Recently, it has been proposed that low empathizing and high systemizing characterize individuals with ASCs. Empathizing is the drive to identify the mental status of other individuals and respond to it with an appropriate emotion; systemizing is the drive to analyze a system. It has been proposed that this higher systemizing underlies the scientific achievement of individuals with ASCs, suggesting the possible positive association between creativity and systemizing. However, previous findings on the association between ASCs and creativity were conflicting. Conversely, previous studies have suggested an association between prosocial traits and creativity, indicating the possible association between empathizing and creativity. Here we investigated the association between creativity measured by divergent thinking (CDT) and empathizing, systemizing, and the discrepancy between systemizing and empathizing, which is called D score. CDT was measured using the S-A creativity test. The individual degree of empathizing (empathizing quotient, EQ) and that of systemizing (systemizing quotient, SQ), and D score was measured via a validated questionnaire (SQ and EQ questionnaires). The results showed that higher CDT was significantly and positively correlated with both the score of EQ and the score of SQ but not with D score. These results suggest that CDT is positively associated with one of the characteristics of ASCs (analytical aspects), while exhibiting a negative association with another (lower social aspects). Therefore, the discrepancy between systemizing and empathizing, which is strongly associated with autistic tendency, was not associated with CDT.
C1 [Takeuchi, Hikaru; Taki, Yasuyuki; Hashizume, Hiroshi; Sassa, Yuko; Kawashima, Ryuta] Tohoku Univ, Inst Dev Aging & Canc, Div Dev Cognit Neurosci, Sendai, Miyagi 9808575, Japan.
   [Taki, Yasuyuki] Tohoku Univ, Div Med Neuroimaging Anal, Dept Community Med Supports, Tohoku Med Megabank Org, Sendai, Miyagi 9808575, Japan.
   [Taki, Yasuyuki; Sekiguchi, Atsushi] Tohoku Univ, Dept Radiol & Nucl Med, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan.
   [Sekiguchi, Atsushi; Nakagawa, Seishu; Miyauchi, Carlos M.; Iizuka, Kunio; Yokoyama, Ryoichi; Shinada, Takamitsu; Yamamoto, Yuki; Hanawa, Sugiko; Kawashima, Ryuta] Tohoku Univ, Dept Funct Brain Imaging, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan.
   [Nouchi, Rui] Tohoku Univ, Human & Social Response Res Div, Int Res Inst Disaster Sci, Sendai, Miyagi 9808575, Japan.
   [Nouchi, Rui; Kotozaki, Yuka; Araki, Tsuyoshi; Kawashima, Ryuta] Tohoku Univ, Smart Ageing Int Res Ctr, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan.
   [Yokoyama, Ryoichi] Japan Soc Promot Sci, Tokyo, Japan.
RP Takeuchi, H (reprint author), Tohoku Univ, Inst Dev Aging & Canc, Div Dev Cognit Neurosci, Aoba Ku, 4-1 Seiryo Cho, Sendai, Miyagi 9808575, Japan.
EM takehi@idac.tohoku.ac.jp
CR Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731
   Baron R., 2000, HDB EMOTIONAL INTELL, P363
   Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
   Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
   Baron-Cohen S, 2004, ESSENTIAL DIFFERENCE
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Benjamini Y, 2006, BIOMETRIKA, V93, P491, DOI 10.1093/biomet/93.3.491
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Billington J, 2007, LEARN INDIVID DIFFER, V17, P260, DOI 10.1016/j.lindif.2007.02.004
   Burgess PW, 1998, J INT NEUROPSYCH SOC, V4, P547
   Chavez-Eakle RA, 2007, NEUROIMAGE, V38, P519, DOI 10.1016/j.neuroimage.2007.07.059
   Chavez-Eakle RA, 2006, CREATIVITY RES J, V18, P27, DOI 10.1207/s15326934crj1801_4
   Claridge G, 2009, PERS INDIV DIFFER, V46, P794, DOI 10.1016/j.paid.2009.01.018
   DeGutis J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058253
   Derntl B, 2009, SCHIZOPHR RES, V108, P197, DOI 10.1016/j.schres.2008.11.009
   Dimaggio G, 2008, CONSCIOUS COGN, V17, P778, DOI 10.1016/j.concog.2008.02.005
   Dimaggio G, 2009, CONSCIOUS COGN, V18, P653, DOI 10.1016/j.concog.2009.06.003
   Dziobek I, 2012, EMOT REV, V4, P18, DOI 10.1177/1754073911421390
   Fink A, 2010, NEUROIMAGE, V52, P1687, DOI 10.1016/j.neuroimage.2010.05.072
   Fink A, 2012, HUM BRAIN MAPP, V33, P2603, DOI 10.1002/hbm.21387
   Focquaert F, 2007, PERS INDIV DIFFER, V43, P619, DOI 10.1016/j.paid.2007.01.004
   Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X
   Gardner K, 2009, PERS INDIV DIFFER, V47, P94, DOI 10.1016/j.paid.2009.02.004
   Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
   Goldenfeld N., 2006, CLIN NEUROPSYCHIATRY, V2, P338
   Guilford J. P., 1967, NAT HUM INTELL, P138
   HEAUSLER NL, 1988, EDUC PSYCHOL MEAS, V48, P463, DOI 10.1177/0013164488482021
   Jung RE, 2010, HUM BRAIN MAPP, V31, P398, DOI 10.1002/hbm.20874
   Kim KH, 2008, J CREATIVE BEHAV, V42, P106
   Lai MC, 2012, NEUROIMAGE, V61, P1347, DOI 10.1016/j.neuroimage.2012.03.018
   Lam LT, 2002, J SOC PSYCHOL, V142, P133
   Liu MJ, 2011, RES AUTISM SPECT DIS, V5, P294, DOI 10.1016/j.rasd.2010.04.011
   Lysaker PH, 2008, J NERV MENT DIS, V196, P384, DOI 10.1097/NMD.0b013e3181710916
   Lysaker PH, 2010, SCHIZOPHR RES, V122, P124, DOI 10.1016/j.schres.2009.04.024
   Lysaker PH, 2011, PSYCHIAT RES, V190, P18, DOI 10.1016/j.psychres.2010.07.016
   Lysaker PH, 2002, PSYCHIATRY, V65, P197, DOI 10.1521/psyc.65.3.197.20174
   Montgomery JM, 2010, EDUC TRAIN AUTISM DE, V45, P566
   Montgomery J.M., 2008, CANADIAN J SCH PSYCH, V23, P70, DOI DOI 10.1177/0829573508316594
   Nettle D, 2006, PERS INDIV DIFFER, V40, P375, DOI 10.1016/j.paid.2005.07.008
   Nettle D, 2007, BRIT J PSYCHOL, V98, P237, DOI 10.1348/000712606X117612
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Penton-Voak IS, 2007, PERS INDIV DIFFER, V43, P2229, DOI 10.1016/j.paid.2007.07.004
   Prigatano G. P., 1991, AWARENESS DEFICIT BR, P11
   Raven J., 1998, MANUAL RAVENS PROGR
   Rawlings D, 2008, J RES PERS, V42, P465, DOI 10.1016/j.jrp.2007.06.005
   Runco M. A., 1990, GIFTED CHILD TODAY, V13, P37, DOI 10.1177/107621759001300411
   Runco MA, 2012, CREATIVITY RES J, V24, P92, DOI 10.1080/10400419.2012.650092
   Saxe R, 2006, SOC COGN AFFECT NEUR, V1, P229, DOI 10.1093/scan/nsl034
   Shimonaka Y, 2007, JPN J EDUC PSYCHOL, V55, P231
   Society_For_Creative_Minds, 1969, MAN S A CREAT TEST
   Song M, 2008, NEUROIMAGE, V41, P1168, DOI 10.1016/j.neuroimage.2008.02.036
   Stein MI, 1953, J PSYCHOL, V36, P311
   Sternberg R. J., 2005, HDB CREATIVITY
   Stileman E., 2007, THESIS U EDINBURGH E
   Takeuchi H, 2010, NEUROIMAGE, V51, P11, DOI 10.1016/j.neuroimage.2010.02.035
   Takeuchi H, 2014, NEUROIMAGE, V99, P312, DOI 10.1016/j.neuroimage.2014.05.031
   Takeuchi H, 2012, NEUROIMAGE, V63, P1119, DOI 10.1016/j.neuroimage.2012.08.037
   Takeuchi H, 2013, NEUROIMAGE, V77, P222, DOI 10.1016/j.neuroimage.2013.04.004
   Takeuchi H, 2011, NEUROIMAGE, V55, P681, DOI 10.1016/j.neuroimage.2010.11.052
   Takeuchi H, 2014, HUM BRAIN MAPP, V35, P185, DOI 10.1002/hbm.22167
   Takeuchi H, 2013, CORTEX, V49, P1148, DOI 10.1016/j.cortex.2013.01.014
   Takeuchi H, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00875
   Takeuchi H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084782
   Takeuchi H, 2010, NEUROIMAGE, V51, P578, DOI 10.1016/j.neuroimage.2010.02.078
   Takeuchi H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025532
   Takeuchi H., 2010, HUM BRAIN MAPP, V32, P1497, DOI [10.1002/hbm.21122, DOI 10.1002/HBM.21122]
   Takeuchi H, 2012, CEREB CORTEX, V22, P2921, DOI 10.1093/cercor/bhr371
   Takeuchi H, 2011, NEUROPSYCHOLOGIA, V49, P3466, DOI 10.1016/j.neuropsychologia.2011.08.022
   Taki Y, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015213
   Taki Y., 2011, NEUROIMAGE, V59, P1023, DOI DOI 10.1016/J.NEUR0IMAGE.2011.08.092
   Torrance E. P., 1966, TORRANCE TESTS CREAT
   Treffinger D. J., 1985, 9 MENTAL MEASUREMENT, P1632
   Wakabayashi Akio, 2006, Shinrigaku Kenkyu, V77, P271
   Wakabayashi A, 2006, PERS INDIV DIFFER, V41, P929, DOI 10.1016/j.paid.2006.03.017
   Wakabayashi A, 2007, J AUTISM DEV DISORD, V37, P1823, DOI 10.1007/s10803-006-0316-6
   Watanabe T, 1998, Shinrigaku Kenkyu, V68, P478
   Wei DT, 2014, CORTEX, V51, P92, DOI 10.1016/j.cortex.2013.09.004
   Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
   World Medical Association, 1991, J LAW MED ETHICS, V19, P264, DOI DOI 10.1111/J.1748-720X.1991.TBO1824.X
   Wray S., 2007, P PPIG 19 ANN WORKSH
NR 81
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD AUG 19
PY 2014
VL 5
AR 921
DI 10.3389/fpsyg.2014.00921
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA AO5JJ
UT WOS:000341380200001
PM 25191299
ER

PT J
AU Parker, KJ
   Garner, JP
   Libove, RA
   Hyde, SA
   Hornbeak, KB
   Carson, DS
   Liao, CP
   Phillips, JM
   Hallmayer, JF
   Hardan, AY
AF Parker, Karen J.
   Garner, Joseph P.
   Libove, Robin A.
   Hyde, Shellie A.
   Hornbeak, Kirsten B.
   Carson, Dean S.
   Liao, Chun-Ping
   Phillips, Jennifer M.
   Hallmayer, Joachim F.
   Hardan, Antonio Y.
TI Plasma oxytocin concentrations and OXTR polymorphisms predict social
   impairments in children with and without autism spectrum disorder
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
ID RECEPTOR GENE OXTR; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC
   INTERVIEW; GENOME-WIDE; BEHAVIOR; ASSOCIATION; BRAIN; HUMANS;
   NEUROPEPTIDES; VASOPRESSIN
AB The neuropeptide oxytocin (OXT) and its receptor (OXTR) regulate social functioning in animals and humans. Initial clinical research suggests that dysregulated plasma OXT concentrations and/or OXTR SNPs may be biomarkers of social impairments in autism spectrum disorder (ASD). We do not know, however, whether OXT dysregulation is unique to ASD or whether OXT biology influences social functioning more generally, thus contributing to, but not causing, ASD phenotypes. To distinguish between these possibilities, we tested in a child ASD cohort, which included unaffected siblings and unrelated neurotypical controls (ages 3-12 y; n = 193), whether plasma OXT concentrations and OXTR SNPs (i) interact to produce ASD phenotypes, (ii) exert differential phenotypic effects in ASD vs. non-ASD children, or (iii) have similar phenotypic effects independent of disease status. In the largest cohort tested to date, we found no evidence to support the OXT deficit hypothesis of ASD. Rather, OXT concentrations strongly and positively predicted theory of mind and social communication performance in all groups. Furthermore, OXT concentrations showed significant heritability between ASD-discordant siblings (h(2) = 85.5%); a heritability estimate on par with that of height in humans. Finally, carriers of the "G" allele of rs53576 showed impaired affect recognition performance and carriers of the "A" allele of rs2254298 exhibited greater global social impairments in all groups. These findings indicate that OXT biology is not uniquely associated with ASD, but instead exerts independent, additive, and highly heritable influences on individual differences in human social functioning, including the severe social impairments which characterize ASD.
C1 [Parker, Karen J.; Garner, Joseph P.; Libove, Robin A.; Hyde, Shellie A.; Hornbeak, Kirsten B.; Carson, Dean S.; Liao, Chun-Ping; Phillips, Jennifer M.; Hallmayer, Joachim F.; Hardan, Antonio Y.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Garner, Joseph P.] Stanford Univ, Sch Med, Dept Comparat Med, Stanford, CA 94305 USA.
RP Parker, KJ (reprint author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM kjparker@stanford.edu
FU National Institutes of Health [RR000167]; Simons Foundation Autism
   Research Initiative; Mosbacher Family Fund for Autism Research; Escher
   Fund at the Silicon Valley Community Foundation; Stanford University's
   Child Health Research Institute
FX We thank Wendy Kalkus, Serena Tanaka, Kaeli Yuen, and Katy Brewster for
   help with blood sample collection and processing as well as data entry.
   We also thank Dr. Carl Feinstein (Director of the Stanford Autism
   Center) for his unwavering support of this research program.
   Additionally, we thank Dr. Toni Zeigler and Dan Wittwer (University of
   Wisconsin National Primate Research Center Assay Services) for
   conducting the OXT assays which were made possible by National
   Institutes of Health Grant RR000167. This research program was supported
   by grants from the Simons Foundation Autism Research Initiative (to
   K.J.P.), the Mosbacher Family Fund for Autism Research (to K.J.P.), the
   Escher Fund at the Silicon Valley Community Foundation (to A.Y.H.), and
   Stanford University's Child Health Research Institute (to K.J.P. and
   A.Y.H.).
CR Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P47
   Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
   Bakermans-Kranenburg MJ, 2014, PSYCHIAT GENET, V24, P45, DOI 10.1097/YPG.0b013e3283643684
   Bishop DVM, 2006, AM J MED GENET B, V141B, P117, DOI 10.1002/ajmg.b.30267
   Carter CS, 2008, PROG BRAIN RES, V170, P331, DOI 10.1016/S0079-6123(08)00427-5
   Chen FS, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00200
   Clark CL, 2013, PSYCHONEUROENDOCRINO, V38, P1208, DOI 10.1016/j.psyneuen.2012.10.017
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Costa B, 2009, PSYCHONEUROENDOCRINO, V34, P1506, DOI 10.1016/j.psyneuen.2009.05.006
   Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015
   Feldman R, 2011, DEVELOPMENTAL SCI, V14, P752, DOI 10.1111/j.1467-7687.2010.01021.x
   Ferguson JN, 2000, NAT GENET, V25, P284, DOI 10.1038/77040
   Gordon I, 2013, P NATL ACAD SCI USA, V110, P20953, DOI 10.1073/pnas.1312857110
   Grafen A, 2002, MODERN STAT LIFE SCI, p[xv, 351]
   INSEL TR, 1992, P NATL ACAD SCI USA, V89, P5981, DOI 10.1073/pnas.89.13.5981
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Jansen LMC, 2006, J AUTISM DEV DISORD, V36, P891, DOI 10.1007/s10803-006-0124-z
   Kim HS, 2010, P NATL ACAD SCI USA, V107, P15717, DOI 10.1073/pnas.1010830107
   Korkman M, 2007, NEPSY 2 CLIN INTERPR
   Kosfeld M, 2005, NATURE, V435, P673, DOI 10.1038/nature03701
   Lauritsen MB, 2006, MOL PSYCHIATR, V11, P37, DOI 10.1038/sj.mp.4001754
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
   Lim MM, 2005, INT J DEV NEUROSCI, V23, P235, DOI 10.1016/j.ijdevneu.2004.05.006
   Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Macgregor S, 2006, HUM GENET, V120, P571, DOI 10.1007/s00439-006-0240-z
   Maestripieri D, 2009, PHYSIOL BEHAV, V96, P613, DOI 10.1016/j.physbeh.2008.12.016
   McCauley JL, 2005, BMC MED GENET, V6, DOI 10.1186/1471-2350-6-1
   Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
   Miller M, 2013, AUTISM RES, V6, P91, DOI 10.1002/aur.1270
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Oved K, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.86
   Park J, 2010, PROG NEURO-PSYCHOPH, V34, P697, DOI 10.1016/j.pnpbp.2010.03.029
   Parker KJ, 2001, BEHAV NEUROSCI, V115, P1341, DOI 10.1037/0735-7044.115.6.1341
   Pine E, 2006, AUTISM, V10, P344, DOI 10.1177/1362361306064434
   Rodrigues SM, 2009, P NATL ACAD SCI USA, V106, P21437, DOI 10.1073/pnas.0909579106
   Roid GH, 2003, STANFORD BINETS INTE
   Shao YJ, 2002, AM J MED GENET, V114, P99, DOI 10.1002/ajmg.10153
   SIMMONS CF, 1995, GENOMICS, V26, P623, DOI 10.1016/0888-7543(95)80188-R
   Skuse DH, 2014, P NATL ACAD SCI USA, V111, P1987, DOI 10.1073/pnas.1302985111
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Thompson RJ, 2011, PSYCHONEUROENDOCRINO, V36, P144, DOI 10.1016/j.psyneuen.2010.07.003
   Van Vleck LD, 1993, SELECTION INDEX INTR
   Winslow JT, 2003, NEUROPSYCHOPHARMACOL, V28, P910, DOI 10.1038/sj.npp.1300128
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Yamasue H, 2013, BRAIN DEV-JPN, V35, P111, DOI 10.1016/j.braindev.2012.08.010
   Ylisaukko-oja T, 2006, ANN NEUROL, V59, P145, DOI 10.1002/ana.20722
   Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015
NR 52
TC 4
Z9 4
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 19
PY 2014
VL 111
IS 33
BP 12258
EP 12263
DI 10.1073/pnas.1402236111
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AN2TS
UT WOS:000340438800080
PM 25092315
ER

PT J
AU Dal Monte, O
   Noble, PL
   Turchi, J
   Cummins, A
   Averbeck, BB
AF Dal Monte, Olga
   Noble, Pamela L.
   Turchi, Janita
   Cummins, Alex
   Averbeck, Bruno B.
TI CSF and Blood Oxytocin Concentration Changes following Intranasal
   Delivery in Macaque
SO PLOS ONE
LA English
DT Article
ID CEREBROSPINAL-FLUID; PLASMA OXYTOCIN; RHESUS-MONKEYS; MACACA-MULATTA;
   DRUG-DELIVERY; BRAIN-BARRIER; SPINAL-CORD; VASOPRESSIN; RATS; HUMANS
AB Oxytocin (OT) in the central nervous system (CNS) influences social cognition and behavior, making it a candidate for treating clinical disorders such as schizophrenia and autism. Intranasal administration has been proposed as a possible route of delivery to the CNS for molecules like OT. While intranasal administration of OT influences social cognition and behavior, it is not well established whether this is an effective means for delivering OT to CNS targets. We administered OT or its vehicle (saline) to 15 primates (Macaca mulatta), using either intranasal spray or a nebulizer, and measured OT concentration changes in the cerebral spinal fluid (CSF) and in blood. All subjects received both delivery methods and both drug conditions. Baseline samples of blood and CSF were taken immediately before drug administration. Blood was collected every 10 minutes after administration for 40 minutes and CSF was collected once post-delivery, at the 40 minutes time point. We found that intranasal administration of exogenous OT increased concentrations in both CSF and plasma compared to saline. Both delivery methods resulted in similar elevations of OT concentration in CSF, while the changes in plasma OT concentration were greater after nasal spray compared to nebulizer. In conclusion our study provides evidence that both nebulizer and nasal spray OT administration can elevate CSF OT levels.
C1 [Dal Monte, Olga; Noble, Pamela L.; Turchi, Janita; Cummins, Alex; Averbeck, Bruno B.] NIH, NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA.
   [Dal Monte, Olga] Univ Turin, Dept Neuropsychol, Turin, Italy.
RP Averbeck, BB (reprint author), NIH, NIMH, Neuropsychol Lab, Bldg 10, Bethesda, MD 20892 USA.
EM averbeckbb@mail.nih.gov
FU Intramural Research Program of the NIMH/NIH/DHHS
FX This research was supported by the Intramural Research Program of the
   NIMH/NIH/DHHS. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
CR AMICO JA, 1983, J CLIN ENDOCR METAB, V57, P947
   AMICO JA, 1990, J CLIN ENDOCR METAB, V71, P1531
   Appenrodt E, 1998, PHYSIOL BEHAV, V64, P543, DOI 10.1016/S0031-9384(98)00119-X
   ARTMAN HG, 1982, J NEUROSCI, V2, P598
   Born J, 2002, NAT NEUROSCI, V5, P514, DOI 10.1038/nn849
   Bosch OJ, 2005, J NEUROSCI, V25, P6807, DOI 10.1523/JNEUROSCI.1342-05.2005
   BOYD NRH, 1972, J ENDOCRINOL, V52, P59, DOI 10.1677/joe.0.0520059
   Burri A, 2008, PSYCHONEUROENDOCRINO, V33, P591, DOI 10.1016/j.psyneuen.2008.01.014
   Chang SWC, 2012, P NATL ACAD SCI USA, V109, P959, DOI 10.1073/pnas.1114621109
   Chen XQ, 1998, J ALZHEIMERS DIS, V1, P35
   Clark CL, 2013, PSYCHONEUROENDOCRINO, V38, P1208, DOI 10.1016/j.psyneuen.2012.10.017
   Devarajan K, 2004, NEUROSCI LETT, V367, P144, DOI 10.1016/j.neulet.2004.05.112
   Dhanda D.S., 2005, DRUG DELIV TECHNOL, V5, P64
   ERMISCH A, 1985, J CEREBR BLOOD F MET, V5, P350
   Evans S, 2011, PSYCHOL MED, V41, P1471, DOI 10.1017/S0033291710001960
   Frey II WH, 2002, DRUG DELIV TECHNOL, V2, P46
   Gamer M, 2010, P NATL ACAD SCI USA, V107, P9400, DOI 10.1073/pnas.1000985107
   Gossen A, 2012, NEUROPEPTIDES, V46, P211, DOI 10.1016/j.npep.2012.07.001
   Green LA, 2001, BIOL PSYCHIAT, V50, P609, DOI 10.1016/S0006-3223(01)01139-8
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Guastella AJ, 2013, PSYCHONEUROENDOCRINO, V38, P612, DOI 10.1016/j.psyneuen.2012.11.019
   Heinrichs M, 2009, FRONT NEUROENDOCRIN, V30, P548, DOI 10.1016/j.yfrne.2009.05.005
   Illum L, 2003, J CONTROL RELEASE, V87, P187, DOI 10.1016/S0168-3659(02)00363-2
   Insel T R, 2001, Prog Brain Res, V133, P59
   Jokinen J, 2012, PSYCHONEUROENDOCRINO, V37, P482, DOI 10.1016/j.psyneuen.2011.07.016
   Kagerbauer SM, 2013, J NEUROENDOCRINOL, V25, P668, DOI 10.1111/jne.12038
   Kirsch P, 2005, J NEUROSCI, V25, P11489, DOI 10.1523/JNEUROSCI.3984-05.2005
   Lee R, 2009, PSYCHONEUROENDOCRINO, V34, P1567, DOI 10.1016/j.psyneuen.2009.06.002
   Martinez-Lorenzan G, 2008, PAIN, V140, P265, DOI 10.1016/j.pain.2008.08.015
   McCarthy MM, 1996, PHYSIOL BEHAV, V60, P1209
   McCullough EM, 2013, NEUROSCI BIOBEHAV R, V37, P1485
   MEISENBERG G, 1983, LIFE SCI, V32, P2611, DOI 10.1016/0024-3205(83)90352-1
   Modi EM, 2014, PSYCHONEUROENDOCRINO, V45, P49
   Neumann ID, 2013, PSYCHONEUROENDOCRINO, V38, P1985, DOI 10.1016/j.psyneuen.2013.03.003
   Parker KJ, 2010, BEHAV NEUROSCI, V124, P428, DOI 10.1037/a0019576
   Parr LA, 2013, PSYCHONEUROENDOCRINO, V38, P1748, DOI 10.1016/j.psyneuen.2013.02.011
   Rimmele U, 2009, J NEUROSCI, V29, P38, DOI 10.1523/JNEUROSCI.4260-08.2009
   ROBINSON ICAF, 1993, ANN NY ACAD SCI, V689, P269
   Robinson JK, 2014, J NEUROSCI METH, V226, P73
   SECKL JR, 1987, J ENDOCRINOL, V114, P477, DOI 10.1677/joe.0.1140477
   Singer T, 2008, EMOTION, V8, P781, DOI 10.1037/a0014195
   Stoop R, 2012, NEURON, V76, P142, DOI 10.1016/j.neuron.2012.09.025
   Striepens N, 2013, SCI REPORTS, V3
   Szeto A, 2011, PSYCHOSOM MED, V73, P393, DOI 10.1097/PSY.0b013e31821df0c2
   Thorne RG, 2004, NEUROSCIENCE, V127, P481, DOI 10.1016/j.neuroscience.2004.05.029
   THORNE RG, 1995, BRAIN RES, V692, P278, DOI 10.1016/0006-8993(95)00637-6
   Weisman O, 2012, PSYCHONEUROENDOCRINO, V38, P694
   Winslow JT, 2003, NEUROPSYCHOPHARMACOL, V28, P910, DOI 10.1038/sj.npp.1300128
NR 48
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 18
PY 2014
VL 9
IS 8
AR e103677
DI 10.1371/journal.pone.0103677
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO4JF
UT WOS:000341302700015
PM 25133536
ER

PT J
AU Kim, JW
   Seung, H
   Kwon, KJ
   Ko, MJ
   Lee, EJ
   Oh, HA
   Choi, CS
   Kim, KC
   Gonzales, EL
   You, JS
   Choi, DH
   Lee, J
   Han, SH
   Yang, SM
   Cheong, JH
   Shin, CY
   Bahn, GH
AF Kim, Ji-Woon
   Seung, Hana
   Kwon, Kyung Ja
   Ko, Mee Jung
   Lee, Eun Joo
   Oh, Hyun Ah
   Choi, Chang Soon
   Kim, Ki Chan
   Gonzales, Edson Luck
   You, Jueng Soo
   Choi, Dong-Hee
   Lee, Jongmin
   Han, Seol-Heui
   Yang, Sung Min
   Cheong, Jae Hoon
   Shin, Chan Young
   Bahn, Geon Ho
TI Subchronic Treatment of Donepezil Rescues Impaired Social, Hyperactive,
   and Stereotypic Behavior in Valproic Acid-Induced Animal Model of Autism
SO PLOS ONE
LA English
DT Article
ID BTBR-T+TF/J MICE; MOUSE MODEL; SPECTRUM DISORDERS; ALZHEIMERS-DISEASE;
   NICOTINIC RECEPTORS; TRANSGENIC MICE; RATS; ACETYLCHOLINE; DEFICITS;
   MEMORY
AB Autism spectrum disorder (ASD) is a group of pervasive developmental disorders with core symptoms such as sociability deficit, language impairment, and repetitive/restricted behaviors. Although worldwide prevalence of ASD has been increased continuously, therapeutic agents to ameliorate the core symptoms especially social deficits, are very limited. In this study, we investigated therapeutic potential of donepezil for ASD using valproic acid-induced autistic animal model (VPA animal model). We found that prenatal exposure of valproic acid (VPA) induced dysregulation of cholinergic neuronal development, most notably the up-regulation of acetylcholinesterase (AChE) in the prefrontal cortex of affected rat and mouse offspring. Similarly, differentiating cortical neural progenitor cell in culture treated with VPA showed increased expression of AChE in vitro. Chromatin precipitation experiments revealed that acetylation of histone H3 bound to AChE promoter region was increased by VPA. In addition, other histone deacetyalse inhibitors (HDACIs) such as trichostatin A and sodium butyrate also increased the expression of AChE in differentiating neural progenitor cells suggesting the essential role of HDACIs in the regulation of AChE expression. For behavioral analysis, we injected PBS or donepezil (0.3 mg/kg) intraperitoneally to control and VPA mice once daily from postnatal day 14 all throughout the experiment. Subchronic treatment of donepezil improved sociability and prevented repetitive behavior and hyperactivity of VPA-treated mice offspring. Taken together, these results provide evidence that dysregulation of ACh system represented by the up-regulation of AChE may serve as an effective pharmacological therapeutic target against autistic behaviors in VPA animal model of ASD, which should be subjected for further investigation to verify the clinical relevance.
C1 [Kim, Ji-Woon; Seung, Hana; Ko, Mee Jung; Lee, Eun Joo; Oh, Hyun Ah; Choi, Chang Soon; Kim, Ki Chan; Gonzales, Edson Luck; You, Jueng Soo; Choi, Dong-Hee; Lee, Jongmin; Han, Seol-Heui; Yang, Sung Min; Shin, Chan Young] Konkuk Univ, Sch Med, Dept Neurosci, Seoul, South Korea.
   [Kwon, Kyung Ja] Konkuk Univ, Ctr Res Neurosci, Inst Biomed Sci & Technol, Seoul, South Korea.
   [Cheong, Jae Hoon] Sahmyook Univ, Coll Pharm, Dept Pharmacol, Seoul, South Korea.
   [Bahn, Geon Ho] Kyung Hee Univ, Sch Med, Dept Neuropsychiat, Seoul, South Korea.
RP Shin, CY (reprint author), Konkuk Univ, Sch Med, Dept Neurosci, Seoul, South Korea.
EM chanyshin@kku.ac.k; mompeian@khu.ac.kr
FU Korean Health Technology R&D Project, Ministry of health & welfare,
   Republic of Korea [A120029]
FX This work was supported by a grant of the Korean Health Technology R&D
   Project, Ministry of health & welfare, Republic of Korea (No. A120029).
   The funder had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Barnes CA, 2000, NEUROSCIENCE, V99, P17, DOI 10.1016/S0306-4522(00)00180-9
   Bevins RA, 2006, NAT PROTOC, V1, P1306, DOI 10.1038/nprot.2006.205
   Bohnen NI, 2011, BEHAV BRAIN RES, V221, P564, DOI 10.1016/j.bbr.2009.12.048
   Chez MG, 2004, J CHILD NEUROL, V19, P165
   Chilian B., 2013, CLIN GENET
   CLAYTONSMITH J, 1995, J MED GENET, V32, P724, DOI 10.1136/jmg.32.9.724
   Cohen O, 2002, MOL PSYCHIATR, V7, P874, DOI 10.1038/sj.mp.4001103
   Cutuli D, 2009, J ALZHEIMERS DIS, V17, P161, DOI 10.3233/JAD-2009-1040
   Deacon R, 2012, JOVE-J VIS EXP, DOI 10.3791/2607
   Deacon RMJ, 2006, NAT PROTOC, V1, P122, DOI 10.1038/nprot.2006.20
   de la Monte SM, 2006, J ALZHEIMERS DIS, V10, P89
   Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
   Erb C, 2001, J NEUROCHEM, V77, P638, DOI 10.1046/j.1471-4159.2001.00287.x
   Francis PT, 1999, J NEUROL NEUROSUR PS, V66, P137, DOI 10.1136/jnnp.66.2.137
   Friedman SD, 2006, ARCH GEN PSYCHIAT, V63, P786, DOI 10.1001/archpsyc.63.7.786
   Ghosh A, 2013, NAT REV DRUG DISCOV, V12, P777, DOI 10.1038/nrd4102
   Gottlicher M, 2001, EMBO J, V20, P6969, DOI 10.1093/emboj/20.24.6969
   Grunstein M, 1997, NATURE, V389, P349, DOI 10.1038/38664
   Hardan AY, 2002, J CHILD ADOL PSYCHOP, V12, P237, DOI 10.1089/104454602760386923
   Hertzman M, 2003, INT J PSYCHIAT MED, V33, P395, DOI 10.2190/JE5Q-1NFT-FL40-7PMW
   Holmes A, 2002, J MOL NEUROSCI, V18, P151, DOI 10.1385/JMN:18:1-2:151
   Huguet G, 2013, ANNU REV GENOM HUM G, V14, P191, DOI 10.1146/annurev-genom-091212-153431
   Iwasaki E, 2012, DIGEST DIS SCI, V57, P858, DOI 10.1007/s10620-011-1953-y
   Karvat G, 2014, NEUROPSYCHOPHARMACOL, V39, P831, DOI 10.1038/npp.2013.274
   Kim KC, 2014, MOL NEUROBIOL, V49, P512, DOI 10.1007/s12035-013-8535-2
   Kim KC, 2011, TOXICOL LETT, V201, P137, DOI 10.1016/j.toxlet.2010.12.018
   Lee M, 2002, BRAIN, V125, P1483, DOI 10.1093/brain/awf160
   LINDHOUT D, 1986, LANCET, V1, P1392
   LINDHOUT D, 1992, EPILEPSIA, V33, pS41
   Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
   Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
   Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   McTighe SM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062189
   Mikhail FM, 2011, AM J MED GENET A, V155A, P2386, DOI 10.1002/ajmg.a.34177
   Moriguchi S, 2005, J PHARMACOL EXP THER, V315, P125, DOI 10.1124/jpet.105.087908
   Nelson JD, 2006, NAT PROTOC, V1, P179, DOI 10.1038/nprot.2006.27
   Nicolson R, 2006, J CHILD ADOL PSYCHOP, V16, P621, DOI 10.1089/cap.2006.16.621
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058
   Petersen AK, 2013, EUR J MED GENET, V56, P118, DOI 10.1016/j.ejmg.2012.11.003
   Phiel CJ, 2001, J BIOL CHEM, V276, P36734, DOI 10.1074/jbc.M101287200
   Picciotto MR, 2012, NEURON, V76, P116, DOI 10.1016/j.neuron.2012.08.036
   Politte LC, 2013, PSYCHOPHARMACOLOGY B
   Ray MA, 2005, NEUROBIOL DIS, V19, P366, DOI 10.1016/j.nbd.2005.01.017
   Riedel G, 2009, BEHAV BRAIN RES, V204, P217, DOI 10.1016/j.bbr.2009.06.012
   Rinaldi T, 2007, P NATL ACAD SCI USA, V104, P13501, DOI 10.1073/pnas.0704391104
   Romberg C, 2011, J NEUROSCI, V31, P3500, DOI 10.1523/JNEUROSCI.5242-10.2011
   Sailaja BS, 2012, P NATL ACAD SCI USA, V109, pE3687, DOI 10.1073/pnas.1209990110
   Sarter M, 2012, NEUROPHARMACOLOGY, V62, P1544, DOI 10.1016/j.neuropharm.2010.12.001
   Sarter M, 2004, NEUROBIOL AGING, V25, P1127, DOI 10.1016/j.neurobiolaging.2003.11.011
   Sarter M, 2011, BEHAV NEUROSCI, V125, P825, DOI 10.1037/a0026227
   Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Shen H, 2010, BRIT J PHARMACOL, V161, P127, DOI 10.1111/j.1476-5381.2010.00894.x
   Silverman JL, 2013, DRUG DISCOV TODAY
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
   Sokol DK, 2002, J CHILD NEUROL, V17, P245, DOI 10.1177/088307380201700401
   Strahl BD, 2000, NATURE, V403, P41
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Ueno K, 2002, BEHAV PHARMACOL, V13, P1
   Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
   Won H, 2013, FRONT MOL NEUROSCI, V6, DOI 10.3389/fnmol.2013.00019
   Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008
   Yang YL, 2009, PSYCHIAT RES-NEUROIM, V174, P81, DOI 10.1016/j.pscychresns.2009.03.012
   Yuan E, 2012, HUM MOL GENET, V21, P4286, DOI 10.1093/hmg/dds262
NR 67
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 18
PY 2014
VL 9
IS 8
AR e104927
DI 10.1371/journal.pone.0104927
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO4JF
UT WOS:000341302700051
PM 25133713
ER

PT J
AU Gaigg, SB
   Bowler, DM
   Gardiner, JM
AF Gaigg, Sebastian B.
   Bowler, Dermot M.
   Gardiner, John M.
TI Episodic but not semantic order memory difficulties in autism spectrum
   disorder: Evidence from the Historical Figures Task
SO MEMORY
LA English
DT Article
DE Memory development; Episodic memory; Semantic memory; Order memory;
   Autism spectrum disorder
ID ASPERGERS-SYNDROME; AUTOBIOGRAPHICAL MEMORY; FREE-RECALL; AUTONOETIC
   CONSCIOUSNESS; AMNESIC SYNDROME; FUTURE THINKING; EARLY-CHILDHOOD;
   ADULTS; CHILDREN; RECOGNITION
AB Considerable evidence suggests that the episodic memory system operates abnormally in autism spectrum disorder (ASD) whereas the functions of the semantic memory system are relatively preserved. Here we show that the same dissociation also applies to the domain of order memory. We asked adult participants to order the names of famous historical figures either according to their chronological order in history (probing semantic memory) or according to a random sequence shown once on a screen (probing episodic memory). As predicted, adults with ASD performed less well than age- and IQ-matched comparison individuals only on the episodic task. This observation is of considerable importance in the context of developmental theory because semantic and episodic order memory abilities can be dissociated in typically developing infants before they reach the age at which the behavioural markers associated with ASD are first apparent. This raises the possibility that early emerging memory abnormalities play a role in shaping the developmental trajectory of the disorder. We discuss the broader implications of this possibility and highlight the urgent need for greater scrutiny of memory competences in ASD early in development.
C1 [Gaigg, Sebastian B.; Bowler, Dermot M.; Gardiner, John M.] City Univ London, Dept Psychol, Northampton EC1V 0HB, England.
RP Gaigg, SB (reprint author), City Univ London, Dept Psychol, Northampton Sq, Northampton EC1V 0HB, England.
EM s.b.gaigg@city.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Atance CM, 2001, TRENDS COGN SCI, V5, P533, DOI 10.1016/S1364-6613(00)01804-0
   BACHEVALIER J, 1994, NEUROPSYCHOLOGIA, V32, P627, DOI 10.1016/0028-3932(94)90025-6
   Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002
   Bauer PJ, 2004, DEV REV, V24, P347, DOI 10.1016/j.dr.2004.08.003
   Bauer PJ, 2000, MONOGR SOC RES CHILD, V65, P1, DOI 10.1111/1540-5834.00104
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bennetto L, 1996, CHILD DEV, V67, P1816, DOI 10.1111/j.1467-8624.1996.tb01830.x
   Bigham S, 2010, J AUTISM DEV DISORD, V40, P878, DOI 10.1007/s10803-010-0937-7
   BOUCHER J, 1976, BRIT J PSYCHOL, V67, P73
   BOUCHER J, 1981, BRIT J PSYCHOL, V72, P211
   Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
   Boucher J, 2008, MEMORY AUTISM THEORY
   Boucher J, 2012, PSYCHOL BULL, V138, P458, DOI 10.1037/a0026869
   Boucher J, 2012, AUTISM, V16, P226, DOI 10.1177/1362361311430403
   Bowler D. M., 2011, RES AUTISTIC SPECTRU, P316, DOI 10.1017/CBO9780511973918.013
   Bowler D. M., 2008, MEMORY AUTISM, P330, DOI DOI 10.1017/CBO9780511490101
   Bowler DA, 2008, NEUROPSYCHOLOGIA, V46, P993, DOI 10.1016/j.neuropsychologia.2007.12.004
   Bowler DM, 2007, CONSCIOUS COGN, V16, P124, DOI 10.1016/j.concog.2005.12.001
   Bowler DM, 2004, J AUTISM DEV DISORD, V34, P533, DOI 10.1007/s10803-004-2548-7
   Bowler DM, 2008, J AUTISM DEV DISORD, V38, P104, DOI 10.1007/s10803-007-0366-4
   Bowler DM, 1997, NEUROPSYCHOLOGIA, V35, P65, DOI 10.1016/S0028-3932(96)00054-1
   Bowler DM, 2000, J ABNORM PSYCHOL, V109, P663, DOI 10.1037//0021-843X.109.4.663
   Brown MW, 2001, NAT REV NEUROSCI, V2, P51, DOI 10.1038/35049064
   Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
   Eichenbaum H, 2004, NEURON, V44, P109, DOI 10.1016/j.neuron.2004.08.028
   Gaigg S. B., 2012, BRIT J ED PSYCHOL MO, V11, P34
   Gaigg S. B., 2008, NEUROPSYCHOLOGIA, V46, P986, DOI DOI 10.1016/J.NEUROPSYCHOLOGIA.2007.11.011
   Gardiner JM, 2001, PHILOS T R SOC B, V356, P1351, DOI 10.1098/rstb.2001.0955
   Bowler DM, 2000, J AUTISM DEV DISORD, V30, P305, DOI 10.1023/A:1005552811441
   Goddard L, 2007, J AUTISM DEV DISORD, V37, P291, DOI 10.1007/s10803-006-0168-0
   Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Healy AF, 2000, J MEM LANG, V42, P147, DOI 10.1006/jmla.1999.2671
   Hermelin B, 1970, PSYCHOL EXPT AUTISTI
   HERMELIN B, 1967, BRIT J PSYCHOL, V58, P213
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Lind S, 2008, MEMORY AUTISM THEORY, P166, DOI DOI 10.1017/CBO9780511490101.011
   Lind SE, 2010, J ABNORM PSYCHOL, V119, P896, DOI 10.1037/a0020631
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mayes A., 2008, MEMORY AUTISM THEORY, P43, DOI DOI 10.1017/CB09780511490101.005
   Minshew N. J., 1993, NEUROPSYCHOLOGY, V7, P209, DOI DOI 10.1037/0894-4105.7.2.209
   Nelson KD, 2004, PSYCHOL REV, V111, P486, DOI 10.1037/0033-295X.111.2.486
   Nicholson R., 2006, PSYCHIAT RES-NEUROIM, V148, P11, DOI [10.1016/j.pscychresns.2006.02.005, DOI 10.1016/J.PSCYCHRESNS.2006.02.005]
   OCONNOR N, 1967, J MENT DEFIC RES, V11, P126
   PERNER J, 1995, J EXP CHILD PSYCHOL, V59, P516, DOI 10.1006/jecp.1995.1024
   Perner Josef, 1991, UNDERSTANDING REPRES
   Poirier M, 2011, J ABNORM PSYCHOL, V120, P247, DOI 10.1037/a0022298
   Poirier M., 2008, MEMORY AUTISM THEORY, P231, DOI 10.1017/CBO9780511490101.014
   Schacter DL, 2008, ANN NY ACAD SCI, V1124, P39, DOI 10.1196/annals.1440.001
   Schacter DL, 2007, PHILOS T R SOC B, V362, P773, DOI 10.1098/rstb.2007.2087
   Smith BJ, 2007, J AUTISM DEV DISORD, V37, P445, DOI 10.1007/s10803-006-0180-4
   TAGERFLUSBERG H, 1991, BRIT J DEV PSYCHOL, V9, P417
   Tanweer T, 2010, NEUROPSYCHOLOGIA, V48, P900, DOI 10.1016/j.neuropsychologia.2009.11.007
   The Psychological Corporation, 2000, WECHSL AD INT SCAL 3
   Tulving E, 2001, PHILOS T ROY SOC B, V356, P1505, DOI 10.1098/rstb.2001.0937
   Waterhouse L, 2013, RETHINKING AUTISM: VARIATION AND COMPLEXITY, P1
   Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
NR 58
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0965-8211
EI 1464-0686
J9 MEMORY
JI Memory
PD AUG 18
PY 2014
VL 22
IS 6
BP 669
EP 678
DI 10.1080/09658211.2013.811256
PG 10
WC Psychology, Experimental
SC Psychology
GA AE4KJ
UT WOS:000333951000007
PM 23815188
ER

PT J
AU Shih, PY
   Lee, SP
   Chen, YK
   Hsueh, YP
AF Shih, Pu-Yun
   Lee, Sue-Ping
   Chen, Yi-Kai
   Hsueh, Yi-Ping
TI Cortactin-binding protein 2 increases microtubule stability and
   regulates dendritic arborization
SO JOURNAL OF CELL SCIENCE
LA English
DT Article
DE Acetylated tubulin; CTTNBP2; Dendritic arborization; Microtubule
   bundling
ID MORPHOLOGY; PROMOTES; TUBULIN; TAU; MORPHOGENESIS; PLASTICITY; ISOFORMS;
   NEURONS; AUTISM; GENE
AB Neurons are characterized by subcellular compartments, such as axons, dendrites and synapses, that have highly specialized morphologies and biochemical specificities. Cortactin-binding protein 2 (CTTNBP2), a neuron-specific F-actin regulator, has been shown to play a role in the regulation of dendritic spine formation and their maintenance. Here, we show that, in addition to F-actin, CTTNBP2 also associates with microtubules before mature dendritic spines form. This association of CTTNBP2 and microtubules induced the formation of microtubule bundles. Although the middle (Mid) region of CTTNBP2 was sufficient for its association with microtubules, for microtubule bundling, the N-terminal region containing the coiled-coil motifs (NCC), which mediates the dimerization or oligomerization of CTTNBP2, was also required. Our study indicates that CTTNBP2 proteins form a dimer or oligomer and brings multiple microtubule filaments together to form bundles. In cultured hippocampal neurons, knockdown of CTTNBP2 or expression of the Mid or NCC domain alone reduced the acetylation levels of microtubules and impaired dendritic arborization. This study suggests that CTTNBP2 influences both the F-actin and microtubule cytoskeletons and regulates dendritic spine formation and dendritic arborization.
C1 [Shih, Pu-Yun; Hsueh, Yi-Ping] Natl Yang Ming Univ, Fac Life Sci, Inst Genome Sci, Taipei 112, Taiwan.
   [Shih, Pu-Yun; Lee, Sue-Ping; Chen, Yi-Kai; Hsueh, Yi-Ping] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan.
RP Hsueh, YP (reprint author), Natl Yang Ming Univ, Fac Life Sci, Inst Genome Sci, Taipei 112, Taiwan.
EM yph@gate.sinica.edu.tw
FU Academia Sinica [AS-100TP- B09, AS-103-TP-B05]; National Science Council
   of Taiwan [NSC 102-2321-B-001-054, NSC 102-2321-B-001-029]
FX This work is supported by grants from Academia Sinica [grant numbers
   AS-100TP-B09, AS-103-TP-B05]; and the National Science Council of Taiwan
   [grant numbers NSC 102-2321-B-001-054, NSC 102-2321-B-001-029] to Y.P.H.
CR Chen CY, 2011, J CELL BIOL, V193, P769, DOI 10.1083/jcb.201008050
   Chen S, 2013, DEV CELL, V24, P26, DOI 10.1016/j.devcel.2012.11.014
   Chen YK, 2012, MOL BIOL CELL, V23, P4383, DOI 10.1091/mbc.E12-05-0365
   Chen YK, 2012, J NEUROSCI, V32, P1043, DOI 10.1523/JNEUROSCI.4405-11.2012
   Cheung J, 2001, GENOMICS, V78, P7, DOI 10.1006/geno.2001.6651
   Fong KW, 2013, J CELL SCI, V126, P825, DOI 10.1242/jcs.116137
   Fukushima N, 2009, J NEUROCHEM, V109, P683, DOI 10.1111/j.1471-4159.2009.06013.x
   Garnham CP, 2012, CYTOSKELETON, V69, P442, DOI 10.1002/cm.21027
   Gu JP, 2008, J NEUROSCI, V28, P12120, DOI 10.1523/JNEUROSCI.2509-08.2008
   Hering H, 2003, J NEUROSCI, V23, P11759
   Hoogenraad CC, 2009, TRENDS CELL BIOL, V19, P669, DOI 10.1016/j.tcb.2009.08.006
   Hu XD, 2008, J NEUROSCI, V28, P13094, DOI 10.1523/JNEUROSCI.3074-08.2008
   Huang C, 1997, J BIOL CHEM, V272, P13911, DOI 10.1074/jbc.272.21.13911
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jaworski J, 2009, NEURON, V61, P85, DOI 10.1016/j.neuron.2008.11.013
   Jaworski J, 2005, J NEUROSCI, V25, P11300, DOI 10.1523/JNEUROSCI.2270-05.2005
   KANAI Y, 1992, EMBO J, V11, P3953
   KANAI Y, 1989, J CELL BIOL, V109, P1173, DOI 10.1083/jcb.109.3.1173
   Luo LQ, 2002, ANNU REV CELL DEV BI, V18, P601, DOI 10.1146/annurev.cellbio.18.031802.150501
   Ohoka Y, 1998, GENES CELLS, V3, P603, DOI 10.1046/j.1365-2443.1998.00216.x
   Ori-McKenney KM, 2012, NEURON, V76, P921, DOI 10.1016/j.neuron.2012.10.008
   Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
   Racz B, 2013, MOL NEUROBIOL, V47, P77, DOI 10.1007/s12035-012-8345-y
   Stewart A, 2012, J NEUROSCI, V32, P11631, DOI 10.1523/JNEUROSCI.0729-12.2012
   TAKEMURA R, 1992, J CELL SCI, V103, P953
   Weaver AM, 2001, CURR BIOL, V11, P370, DOI 10.1016/S0960-9822(01)00098-7
NR 26
TC 1
Z9 1
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
   CAMBS, ENGLAND
SN 0021-9533
EI 1477-9137
J9 J CELL SCI
JI J. Cell Sci.
PD AUG 15
PY 2014
VL 127
IS 16
BP 3521
EP 3534
DI 10.1242/jcs.149476
PG 14
WC Cell Biology
SC Cell Biology
GA AO2TX
UT WOS:000341180000011
PM 24928895
ER

PT J
AU Martin, BS
   Corbin, JG
   Huntsman, MM
AF Martin, Brandon S.
   Corbin, Joshua G.
   Huntsman, Molly M.
TI Deficient tonic GABAergic conductance and synaptic balance in the
   fragile X syndrome amygdala
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
DE tonic inhibition; GABA; amygdala; fragile X syndrome
ID CONTAINING GABA(A) RECEPTORS; ADULT-RAT BRAIN; MOUSE MODEL;
   PHARMACOLOGICAL CHARACTERIZATION; CONTAINING INTERNEURONS; FEEDFORWARD
   INHIBITION; BASOLATERAL AMYGDALA; MENTAL-RETARDATION; PYRAMIDAL NEURONS;
   CGG REPEAT
AB Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability. Comorbidities of FXS such as autism are increasingly linked to imbalances in excitation and inhibition (E/I) as well as dysfunction in GABAergic transmission in a number of brain regions including the amygdala. However, the link between E/I imbalance and GABAergic transmission deficits in the FXS amygdala is poorly understood. Here we reveal that normal tonic GABA(A) receptor-mediated neurotransmission in principal neurons (PNs) of the basolateral amygdala (BLA) is comprised of both delta- and alpha 5-subunit-containing GABA(A) receptors. Furthermore, tonic GABAergic capacity is reduced in these neurons in the Fmr1 knockout (KO) mouse model of FXS (1.5-fold total, 3-fold delta-subunit, and 2-fold alpha 5-subunit mediated) as indicated by application of gabazine (50 mu M), 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP, 1 mu M), and alpha 5ia (1.5 mu M) in whole cell patch-clamp recordings. Moreover, alpha 5-containing tonic GABA(A) receptors appear to preferentially modulate nonsomatic compartments of BLA PNs. Examination of evoked feedforward synaptic transmission in these cells surprisingly revealed no differences in overall synaptic conductance or E/I balance between wild-type (WT) and Fmr1 KO mice. Instead, we observed altered feedforward kinetics in Fmr1 KO PNs that supports a subtle yet significant decrease in E/I balance at the peak of excitatory conductance. Blockade of alpha 5-subunit-containing GABA(A) receptors replicated this condition in WT PNs. Therefore, our data suggest that tonic GABA(A) receptor-mediated neurotransmission can modulate synaptic E/I balance and timing established by feedforward inhibition and thus may represent a therapeutic target to enhance amygdala function in FXS.
C1 [Martin, Brandon S.; Corbin, Joshua G.] Childrens Natl Med Ctr, Ctr Neurosci Res, Washington, DC 20010 USA.
   [Martin, Brandon S.] Georgetown Univ, Med Ctr, Interdisciplinary Program Neurosci, Washington, DC 20007 USA.
   [Huntsman, Molly M.] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO 80045 USA.
   [Huntsman, Molly M.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA.
RP Huntsman, MM (reprint author), Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA.
EM molly.huntsman@ucdenver.edu
FU National Institute of Neurological Disorders and Stroke [NS-053719];
   Epilepsy Foundation; Autism Speaks; FRAXA Foundation
FX This work was supported by grants from National Institute of
   Neurological Disorders and Stroke (M. M. Huntsman; Grant NS-053719), the
   Epilepsy Foundation (B. S. Martin), Autism Speaks (M. M. Huntsman and J.
   G. Corbin), and the FRAXA Foundation (M. M. Huntsman and J. G. Corbin).
CR Adusei DC, 2010, NEUROPHARMACOLOGY, V59, P167, DOI 10.1016/j.neuropharm.2010.05.002
   Ali AB, 2008, CEREB CORTEX, V18, P1260, DOI 10.1093/cercor/bhm160
   Atack JR, 2010, PHARMACOL THERAPEUT, V125, P11, DOI 10.1016/j.pharmthera.2009.09.001
   Atack JR, 2006, DRUG METAB DISPOS, V34, P887, DOI 10.1124/dmd.105.006973
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Bonin RP, 2007, J NEUROPHYSIOL, V98, P2244, DOI 10.1152/jn.00482.2007
   Brager DH, 2014, BRAIN RES BULL, V103, P11, DOI 10.1016/j.brainresbull.2014.01.002
   Brickley SG, 2012, NEURON, V73, P23, DOI 10.1016/j.neuron.2011.12.012
   Brown N, 2002, BRIT J PHARMACOL, V136, P965, DOI 10.1038/sj.bjp.0704795
   Christie SB, 2002, NEUROREPORT, V13, P2355, DOI 10.1097/01.wnr.0000045008.30898.dd
   Cruikshank SJ, 2007, NAT NEUROSCI, V10, P462, DOI 10.1038/nn1861
   Curia G, 2009, CEREB CORTEX, V19, P1515, DOI 10.1093/cercor/bhn159
   D'Hulst C, 2006, BRAIN RES, V1121, P238, DOI 10.1016/j.brainres.2006.08.115
   Ehrlich I, 2009, NEURON, V62, P757, DOI 10.1016/j.neuron.2009.05.026
   El Idrissi A, 2005, NEUROSCI LETT, V377, P141, DOI 10.1016/j.neulet.2004.11.087
   Farrant M, 2005, NAT REV NEUROSCI, V6, P215, DOI 10.1038/nrn1625
   FRITSCHY JM, 1995, J COMP NEUROL, V359, P154, DOI 10.1002/cne.903590111
   FU YH, 1991, CELL, V67, P1047, DOI 10.1016/0092-8674(91)90283-5
   Gabernet L, 2005, NEURON, V48, P315, DOI 10.1016/j.neuron.2005.09.022
   Gantois I, 2006, NEUROBIOL DIS, V21, P346, DOI 10.1016/j.nbd.2005.07.017
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008
   Glykys J, 2007, J PHYSIOL-LONDON, V582, P1163, DOI 10.1113/jphysiol.2007.134460
   Goncalves JT, 2013, NAT NEUROSCI, V16, P903, DOI 10.1038/nn.3415
   Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
   Hays SA, 2011, J NEUROSCI, V31, P14223, DOI 10.1523/JNEUROSCI.3157-11.2011
   He CX, 2013, NEUROSCIENCE, V251, P120, DOI 10.1016/j.neuroscience.2012.03.049
   Huntsman MM, 2000, J NEUROPHYSIOL, V83, P350
   Isaacson JS, 2011, NEURON, V72, P231, DOI 10.1016/j.neuron.2011.09.027
   Konig P, 1996, TRENDS NEUROSCI, V19, P130, DOI 10.1016/S0166-2236(96)80019-1
   KRETTEK JE, 1978, J COMP NEUROL, V178, P255, DOI 10.1002/cne.901780205
   Krook-Magnuson EI, 2008, J NEUROPHYSIOL, V100, P932, DOI 10.1152/jn.01360.2007
   LLOYD DPC, 1946, J NEUROPHYSIOL, V9, P421
   Manko M, 2012, J PHYSIOL-LONDON, V590, P5611, DOI 10.1113/jphysiol.2012.236745
   Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
   Marowsky A, 2012, J NEUROSCI, V32, P8611, DOI 10.1523/JNEUROSCI.4404-11.2012
   Martin LJ, 2010, J NEUROSCI, V30, P5269, DOI 10.1523/JNEUROSCI.4209-09.2010
   McDonald AJ, 2005, BRAIN RES, V1035, P32, DOI 10.1016/j.brainres.2004.11.052
   McDonald AJ, 1996, NEUROSCIENCE, V71, P37, DOI 10.1016/0306-4522(95)00416-5
   MCNAUGHTON BL, 1981, J NEUROPHYSIOL, V46, P952
   Mitchell SJ, 2003, NEURON, V38, P433, DOI 10.1016/S0896-6273(03)00200-9
   Muller JF, 2007, J COMP NEUROL, V500, P513, DOI 10.1002/cne.21185
   NICOLL A, 1993, J PHYSIOL-LONDON, V468, P693
   Olmos-Serrano JL, 2010, J NEUROSCI, V30, P9929, DOI 10.1523/JNEUROSCI.1714-10.2010
   OTTERSEN OP, 1982, J COMP NEUROL, V205, P30, DOI 10.1002/cne.902050104
   Paluszkiewicz SM, 2011, DEV NEUROSCI-BASEL, V33, P349, DOI 10.1159/000329420
   Paluszkiewicz SM, 2011, J NEUROPHYSIOL, V106, P2264, DOI 10.1152/jn.00421.2011
   Pirker S, 2000, NEUROSCIENCE, V101, P815, DOI 10.1016/S0306-4522(00)00442-5
   Poo C, 2009, NEURON, V62, P850, DOI 10.1016/j.neuron.2009.05.022
   Postlethwaite M, 2007, J PHYSIOL-LONDON, V579, P69, DOI 10.1113/jphysiol.2006.123612
   Pouille F, 2001, SCIENCE, V293, P1159, DOI 10.1126/science.1060342
   Quirk K, 1996, NEUROPHARMACOLOGY, V35, P1331, DOI 10.1016/S0028-3908(96)00061-5
   Sah P, 2003, PHYSIOL REV, V83, P803, DOI 10.1152/physrev.00002.2003
   Semyanov A, 2004, TRENDS NEUROSCI, V27, P262, DOI 10.1016/j.tins.2004.03.005
   SMITH Y, 1994, J COMP NEUROL, V342, P232, DOI 10.1002/cne.903420207
   Storustovu SI, 2006, J PHARMACOL EXP THER, V316, P1351, DOI 10.1124/jpet.105.092403
   Stuart G, 1998, J NEUROSCI, V18, P3501
   Testa-Silva G, 2012, CEREB CORTEX, V22, P1333, DOI 10.1093/cercor/bhr224
   VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
   Vislay RL, 2013, J NEUROSCI, V33, P7548, DOI 10.1523/JNEUROSCI.2764-12.2013
   Wehr M, 2003, NATURE, V426, P442, DOI 10.1038/nature02116
   Zhang L, 2008, HIPPOCAMPUS, V18, P294, DOI 10.1002/hipo.20389
   Zhang LH, 2010, J NEUROSCI, V30, P5724, DOI 10.1523/JNEUROSCI.0795-10.2010
NR 63
TC 1
Z9 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
EI 1522-1598
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD AUG 15
PY 2014
VL 112
IS 4
BP 890
EP 902
DI 10.1152/jn.00597.2013
PG 13
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA AN8FR
UT WOS:000340839300013
PM 24848467
ER

PT J
AU Pragnya, B
   Kameshwari, JSL
   Veeresh, B
AF Pragnya, B.
   Kameshwari, J. S. L.
   Veeresh, B.
TI Ameliorating effect of piperine on behavioral abnormalities and
   oxidative markers in sodium valproate induced autism in BALB/C mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Valproate; Mice; Piperine; Behavior
ID CULTURED HIPPOCAMPAL-NEURONS; PRENATAL EXPOSURE; ANIMAL-MODEL; INDUCED
   APOPTOSIS; ACID; RATS; SYSTEM; BRAIN; NOREPINEPHRINE; DISORDERS
AB Post natal exposure to VPA (valproic acid) in mice induces behavioral deficits, abnormal sensitivity to sensory stimuli and self-injurious behavior, observed in autism. Piperine has been reported to have protective effect on brain. The present study aimed at evaluating effect of piperine on VPA induced neurobehavioral and biochemical alterations in BALB/c mice. Young BALB/c mice 13 days old were procured from five different litters and segregated into five groups (n = 6; 3 male, 3 female) i.e., Group I served as control group, received physiological saline on PND (Post natal day) 14 & Tween 80 p.o. from PND13-40. Group II served as normal treated group and received piperine (20 mg/kg p.o.) from PND 13-40 and saline s.c. on PND 14. Group III served as valproate treated group received VPA (400 mg/kg s.c.) on PND 14 and Tween 80 p.o. from PND 13-40. Group IV & V served as disease treated group received VPA (400 mg/kg s.c.) on PND 14 & piperine (5 & 20 mg/kg p.o.) from PND 13-40 respectively. BALB/c mice pups were subjected to behavioral testing to assess motor skill development, nociceptive response, locomotion, anxiety, and cognition on various postnatal days up to PND 40. At the end of behavioral evaluation, mice were sacrificed; brain was isolated for biochemical estimations (serotonin, glutathione, MDA and nitric oxide) and histopathological examination. Our study revealed that treatment with piperine significantly improved behavioral alterations, lowered oxidative stress markers, and restored histoarchitecture of cerebellum. This ameliorating effect of piperine is attributed to its anti-oxidant activity, cognition enhancing and neuroprotective activity. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Pragnya, B.; Kameshwari, J. S. L.; Veeresh, B.] Osmania Univ, Dept Pharmacol, G Pulla Reddy Coll Pharm, Hyderabad 500027, Andhra Pradesh, India.
RP Pragnya, B (reprint author), Osmania Univ, Dept Pharmacol, G Pulla Reddy Coll Pharm, Hyderabad 500027, Andhra Pradesh, India.
EM pragnyareddy.9@gmail.com
CR Allen G, 2006, CLIN NEUROSCI RES, V6, P195, DOI 10.1016/j.cnr.2006.06.002
   American Psychiatric Association, DIAGN STAT MAN MENT
   Banji D, 2011, BRAIN RES, V1410, P141, DOI 10.1016/j.brainres.2011.06.063
   Bernard S, 2001, MED HYPOTHESES, V56, P462, DOI 10.1054/mehy.2000.1281
   Bittigau P, 2002, P NATL ACAD SCI USA, V99, P15089, DOI 10.1073/pnas.222550499
   Brodkin ES, 2007, BEHAV BRAIN RES, V176, P53, DOI 10.1016/j.bbr.2006.06.025
   Burwell RD, 2004, J NEUROSCI, V24, P3826, DOI 10.1523/JNEUROSCI.0410-04.2004
   Chaste Pauline, 2012, Dialogues Clin Neurosci, V14, P281
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Choi BM, 2007, J NUTR BIOCHEM, V18, P615, DOI 10.1016/j.jnutbio.2006.11.012
   Chonpathompikunlert P, 2010, FOOD CHEM TOXICOL, V48, P798, DOI 10.1016/j.fct.2009.12.009
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Fu M, 2010, BIOL PHARM BULL, V33, P598, DOI 10.1248/bpb.33.598
   Gidley Larson JC, 2008, AUTISM RES, V1, P341
   Hranilovic D, 2009, J NEURAL TRANSM, V116, P493, DOI 10.1007/s00702-009-0192-2
   Hranilovic D, 2007, J AUTISM DEV DISORD, V37, P1934, DOI 10.1007/s10803-006-0324-6
   JACOBOWITZ DM, 1978, PHARMACOL BIOCHEM BE, V8, P515, DOI 10.1016/0091-3057(78)90380-5
   Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
   Kini U., 2006, PAEDIAT PERINAT DRUG, V7, P123, DOI DOI 10.1185/146300906X112908
   Mao QQ, 2012, CELL MOL NEUROBIOL, V32, P531, DOI 10.1007/s10571-011-9786-y
   Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
   MAICKEL RP, 1968, INT J NEUROPHARMACOL, V7, P275
   Ming X, 2008, AM J BIOCH BIOTECHNO, V4, P218
   Natori T, 2008, J BIOSCI BIOENG, V105, P164, DOI 10.1263/jbb.105.164
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   PETROSINI L, 1990, EXP BRAIN RES, V82, P472
   Rauscher FM, 2000, J BIOCHEM MOL TOXIC, V14, P329, DOI 10.1002/1099-0461(2000)14:6<329::AID-JBT5>3.0.CO;2-G
   Rice D, 2000, ENVIRON HEALTH PERSP, V108, P511, DOI 10.2307/3454543
   Rinaldi T, 2008, CEREB CORTEX, V18, P763, DOI 10.1093/cercor/bhm117
   Rodier PM, 1998, MENT RETARD DEV D R, V4, P121, DOI 10.1002/(SICI)1098-2779(1998)4:2<121::AID-MRDD9>3.0.CO;2-S
   Sandhya T, 2012, NEUROCHEM RES, V37, P1121, DOI 10.1007/s11064-012-0717-1
   Schneider T, 2001, POL J PHARMACOL, V53, P531
   Schneider T, 2007, PSYCHOPHARMACOLOGY, V193, P547, DOI 10.1007/s00213-007-0795-y
   Schneider T, 2006, NEUROPSYCHOPHARMACOL, V31, P36, DOI 10.1038/sj.npp.1300767
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Selvendiran K, 2003, FITOTERAPIA, V74, P109, DOI 10.1016/S0367-326X(02)00304-0
   Sogut S, 2003, CLIN CHIM ACTA, V331, P111, DOI 10.1016/S0009-8981(03)00119-0
   TERRANOVA ML, 1993, DEV PSYCHOBIOL, V26, P467, DOI 10.1002/dev.420260805
   Thomas JD, 1998, DEV BRAIN RES, V105, P159, DOI 10.1016/S0165-3806(97)00164-8
   Tsikas D, 2007, J CHROMATOGR B, V851, P51, DOI 10.1016/j.jchromb.2006.07.054
   Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y
   Wang CY, 2011, NEUROSCI LETT, V497, P122, DOI 10.1016/j.neulet.2011.04.044
   Wattanathorn J, 2008, FOOD CHEM TOXICOL, V46, P3106, DOI 10.1016/j.fct.2008.06.014
   Yochum CL, 2008, BRAIN RES, V1203, P126, DOI 10.1016/j.brainres.2008.01.055
NR 44
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD AUG 15
PY 2014
VL 270
BP 86
EP 94
DI 10.1016/j.bbr.2014.04.045
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AM2PV
UT WOS:000339694200010
PM 24803211
ER

PT J
AU Ju, A
   Hammerschmidt, K
   Tantra, M
   Krueger, D
   Brose, N
   Ehrenreich, H
AF Ju, Anes
   Hammerschmidt, Kurt
   Tantra, Martesa
   Krueger, Dilja
   Brose, Nils
   Ehrenreich, Hannelore
TI Juvenile manifestation of ultrasound communication deficits in the
   neuroligin-4 null mutant mouse model of autism
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Neuroligin-4; C57BL/6J; Ultrasound or ultrasonic vocalization; Neonatal
   milestones; Neonatal development; Gender
ID MICE; VOCALIZATIONS; BEHAVIORS; MECP2; RATS
AB Neuroligin-4 (Nlgn4) is a member of the neuroligin family of postsynaptic cell adhesion molecules. Loss-of-function mutations of NLGN4 are among the most frequent, known genetic causes of heritable autism. Adult NIgn4 null mutant (N1g174-1-) mice are a construct valid model of human autism, with both genders displaying a remarkable autistic phenotype, including deficits in social interaction and communication as well as restricted and repetitive behaviors. In contrast to adults, autism-related abnormalities in neonatal and juvenile NIgn4-/- mice have not been reported yet. The present study has been designed to systematically investigate in male and female NIgn4-/- pups versus wildtype littermates NIgn4+1+) developmental milestones and stimulus-induced ultrasound vocalization (USV). Neonatal development, followed daily from postnatal days (PND) 4 to 21, including physical development, neurological reflexes and neuromotor coordination, did not yield any differences between NIgn4-/- and their WT littermates. USV in pups (PND8-9) in response to brief separation from their mothers revealed remarkable gender effects, and a genotype influence in females regarding latency to first call. In juveniles (PND22-23), USV monitoring upon exposure to an anesthetized female intruder mouse uncovered a clear genotype effect with reduced USV in NIgn4-/- mice, and again a more prominent phenotype in females. Together, these data support an early manifestation of communication deficits in NIgn4-/- mice that appear more pronounced in immature females with their overall stronger USV as compared to males. (C) 2014 Elsevier B.V. All rights reserved.
C1 Max Planck Inst Expt Med, Clin Neuroscience, Gottingen, Germany.
   [Hammerschmidt, Kurt] DFG Ctr Nanoscale Microscopy & Mol Physiol, Gottingen, Germany.
   [Krueger, Dilja; Brose, Nils] Max Planck Inst Expt Med, Dept Mol Neurobiol, Gottingen, Germany.
RP Ehrenreich, H (reprint author), Max Planck Inst Expt Med, Clin Neuroscience, Gottingen, Germany.
EM ehrenreich@em.mpg.de
FU Max Planck Society; Max Planck Forderstiftung; DFG (CNMPB); EU-AIMS;
   Innovative Medicines Initiative Joint Undertaking [115300]; European
   Union; EFPIA companies; Autism Speaks
FX This work was supported by the Max Planck Society, the Max Planck
   Forderstiftung, the DFG (CNMPB) as well as by EU-AIMS. The research of
   EU-AIMS receives support from the Innovative Medicines Initiative Joint
   Undertaking under grant agreement no. 115300, resources of which are
   composed of financial contribution from the European Union's Seventh
   Framework Programme (FP7/2007-2013), from the EFPIA companies, and from
   Autism Speaks.
CR ALTMAN J, 1975, ANIM BEHAV, V23, P896, DOI 10.1016/0003-3472(75)90114-1
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Bodda C, 2013, AM J PATHOL, V183, P195, DOI 10.1016/j.ajpath.2013.03.019
   Chahrour M, 2008, SCIENCE, V320, P1224, DOI 10.1126/science.1153252
   Cohen S, 2008, SCIENCE, V320, P1172, DOI 10.1126/science.1159146
   Dierssen M, 2002, PHARMACOL BIOCHEM BE, V73, P19, DOI 10.1016/S0091-3057(02)00792-X
   El-Kordi A, 2013, BEHAV BRAIN RES, V251, P41, DOI 10.1016/j.bbr.2012.11.016
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Ey E, 2012, GENES BRAIN BEHAV
   Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
   Hammerschmidt K, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-40
   Heyser CJ, 2001, CURRENT PROTOCOLS NE
   Hill Joanna M., 2008, V39, P131, DOI 10.1007/978-1-60327-099-1_10
   Hoon M, 2011, P NATL ACAD SCI USA, V108, P3053, DOI 10.1073/pnas.1006946108
   Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
   Kramer JH, 1997, NEUROPSYCHOLOGY, V11, P577, DOI 10.1037/0894-4105.11.4.577
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x
   Santos M, 2007, GENES BRAIN BEHAV, V6, P277, DOI 10.1111/j.1601-183X.2006.00258.x
   Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Smith PF, 2005, PROG NEUROBIOL, V75, P391, DOI 10.1016/j.pneurobio.2005.04.004
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   VORHEES CV, 1979, TOXICOL APPL PHARM, V50, P267, DOI 10.1016/0041-008X(79)90152-2
NR 25
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD AUG 15
PY 2014
VL 270
BP 159
EP 164
DI 10.1016/j.bbr.2014.05.019
PG 6
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AM2PV
UT WOS:000339694200020
PM 24855039
ER

PT J
AU Martinez-Martinez, MA
   Pacheco-Torres, J
   Borrell, V
   Canals, S
AF Martinez-Martinez, M. A.
   Pacheco-Torres, J.
   Borrell, V.
   Canals, S.
TI Phenotyping the central nervous system of the embryonic mouse by
   magnetic resonance microscopy
SO NEUROIMAGE
LA English
DT Article
DE MRI; Gadolinium; Embryo; Development; Mouse; Brain
ID GENE-EXPRESSION; CONTRAST AGENTS; NEONATAL MOUSE; MR MICROSCOPY; BRAIN;
   MICE; FOREBRAIN; AUTISM; ATLAS; MODEL
AB Genetic mouse models of neurodevelopmental disorders are being massively generated, but technologies for their high-throughput phenotyping are missing. The potential of high-resolution magnetic resonance imaging (MRI) for structural phenotyping has been demonstrated before. However, application to the embryonic mouse central nervous system has been limited by the insufficient anatomical detail. Here we present a method that combines staining of live embryos with a contrast agent together with MR microscopy after fixation, to provide unprecedented anatomical detail at relevant embryonic stages. By using this method we have phenotyped the embryonic forebrain of Robo1/2(-/-) double mutant mice enabling us to identify most of the well-known anatomical defects in these mutants, as well as novel more subtle alterations. We thus demonstrate the potential of this methodology for a fast and reliable screening of subtle structural abnormalities in the developing mouse brain, as those associated to defects in disease-susceptibility genes of neurologic and psychiatric relevance. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Martinez-Martinez, M. A.; Borrell, V.] CSIC, Inst Neurociencias, Dev Neurobiol Unit, Sant Joan dAlacant 03550, Spain.
   [Martinez-Martinez, M. A.; Pacheco-Torres, J.; Borrell, V.] Univ Miguel Hernandez, Sant Joan dAlacant 03550, Spain.
   [Pacheco-Torres, J.; Canals, S.] CSIC, Inst Neurociencias, Cellular & Syst Neurobiol Unit, Sant Joan dAlacant 03550, Spain.
RP Borrell, V (reprint author), CSIC, Inst Neurociencias, Dev Neurobiol Unit, Sant Joan dAlacant 03550, Spain.
EM vborrell@umh.es; scanals@umh.es
RI Canals, Santiago/N-5838-2014
OI Canals, Santiago/0000-0003-2175-8139
FU Spanish Ministry of Science and Innovation MICINN, Era-Net NEURON
   TRANSALC [CSD2007-00023, BFU2009-09938, BFU2012-39958,
   PIM2010ERN-00679];  [SAF2009-07367];  [BFU2012-33473]
FX We are grateful to M. Tessier-Lavigne for the Robo1/2 mouse colony and
   thankful to C. Vegar, M.A. Fernandez and B. Fernandez for excellent
   technical assistance. Supported by grants from the Spanish Ministry of
   Science and Innovation MICINN to S.C. (CSD2007-00023, BFU2009-09938,
   BFU2012-39958 and PIM2010ERN-00679 as part of the Era-Net NEURON
   TRANSALC project) and to V.B. (CSD2007-00023, SAF2009-07367,
   BFU2012-33473).
CR Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030
   Ahrens ET, 1998, MAGNET RESON MED, V40, P119, DOI 10.1002/mrm.1910400117
   Andrews W, 2006, DEVELOPMENT, V133, P2243, DOI 10.1242/dev.02379
   Borrell V., 2010, NEURON, V76, P338
   Cahill LS, 2012, NEUROIMAGE, V60, P933, DOI 10.1016/j.neuroimage.2012.01.100
   Caravan P, 1999, CHEM REV, V99, P2293, DOI 10.1021/cr980440x
   Chuang N, 2011, NEUROIMAGE, V54, P80, DOI 10.1016/j.neuroimage.2010.07.043
   Cleary JO, 2011, NEUROIMAGE, V54, P769, DOI 10.1016/j.neuroimage.2010.07.039
   Cleary JO, 2011, NEUROIMAGE, V56, P974, DOI 10.1016/j.neuroimage.2011.01.082
   Cleary JO, 2009, NMR BIOMED, V22, P857, DOI 10.1002/nbm.1400
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Denk W, 2012, NAT REV NEUROSCI, V13, P351, DOI 10.1038/nrn3169
   Grillon E, 2008, NMR BIOMED, V21, P427, DOI 10.1002/nbm.1206
   JONES HC, 1992, PROG BRAIN RES, V91, P123
   Kulandavelu S, 2006, ILAR J, V47, P103
   LANENS D, 1993, MAGN RESON IMAGING, V11, P675, DOI 10.1016/0730-725X(93)90009-3
   Lee EF, 2005, ANAT EMBRYOL, V210, P245, DOI 10.1007/s00429-005-0048-y
   Lerch JR, 2011, METHODS MOL BIOL, V711, P349, DOI 10.1007/978-1-61737-992-5_17
   Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728
   Long H, 2004, NEURON, V42, P213, DOI 10.1016/S0896-6273(04)00179-5
   Lopez-Bendito G, 2007, J NEUROSCI, V27, P3395, DOI 10.1523/JNEUROSCI.4605-06.2007
   Manzini MC, 2011, CURR OPIN GENET DEV, V21, P333, DOI 10.1016/j.gde.2011.01.006
   Nguyen-Ba-Charvet KT, 2008, J NEUROSCI, V28, P4244, DOI 10.1523/JNEUROSCI.5671-07.2008
   Norris FC, 2012, MAGN RESON MED, V69, P877
   Paul LK, 2007, NAT REV NEUROSCI, V8, P287, DOI 10.1038/nrn2107
   Petiet AE, 2008, P NATL ACAD SCI USA, V105, P12331, DOI 10.1073/pnas.0805747105
   Puelles L, 2003, TRENDS NEUROSCI, V26, P469, DOI 10.1016/S0166-2236(03)00234-0
   RAKIC P, 1995, NEURON, V14, P1101, DOI 10.1016/0896-6273(95)90258-9
   Rosenthal Julie, 2004, Birth Defects Res C Embryo Today, V72, P213, DOI 10.1002/bdrc.20023
   Ross ME, 2001, ANNU REV NEUROSCI, V24, P1041, DOI 10.1146/annurev.neuro.24.1.1041
   Salomon LJ, 2005, RADIOLOGY, V235, P73, DOI 10.1148/radiol.2351040192
   Schneider Jürgen E, 2004, BMC Dev Biol, V4, P16, DOI 10.1186/1471-213X-4-16
   Sharpe J, 2002, SCIENCE, V296, P541, DOI 10.1126/science.1068206
   Silva AC, 2008, J NEUROSCI METH, V167, P246, DOI 10.1016/j.jneumeth.2007.08.020
   Szulc KU, 2013, MAGN RESON MED, V70, P1707, DOI 10.1002/mrm.24597
   Tomer R, 2012, NAT METHODS, V9, P755, DOI [10.1038/nmeth.2062, 10.1038/NMETH.2062]
   Watson KK, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-21
   Zhang XW, 2010, MAGN RESON MED, V63, P1391, DOI 10.1002/mrm.22322
NR 38
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
EI 1095-9572
J9 NEUROIMAGE
JI Neuroimage
PD AUG 15
PY 2014
VL 97
BP 95
EP 106
DI 10.1016/j.neuroimage.2014.04.043
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AJ8WL
UT WOS:000337988700010
PM 24769183
ER

PT J
AU Bridgman, MW
   Brown, WS
   Spezio, ML
   Leonard, MK
   Adolphs, R
   Paul, LK
AF Bridgman, Matthew W.
   Brown, Warren S.
   Spezio, Michael L.
   Leonard, Matthew K.
   Adolphs, Ralph
   Paul, Lynn K.
TI Facial emotion recognition in agenesis of the corpus callosum
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Corpus callosum agenesis; Corpus callosum; Facial emotion
ID HIGH-FUNCTIONING AUTISM; SENTENCE COMPREHENSION; PSYCHOPHYSICS TOOLBOX;
   SPECTRUM DISORDERS; CHILDREN; DEFICITS; LANGUAGE; CONNECTIVITY;
   PERCEPTION; ADULTS
AB Background: Impaired social functioning is a common symptom of individuals with developmental disruptions in callosal connectivity. Among these developmental conditions, agenesis of the corpus callosum provides the most extreme and clearly identifiable example of callosal disconnection. To date, deficits in nonliteral language comprehension, humor, theory of mind, and social reasoning have been documented in agenesis of the corpus callosum. Here, we examined a basic social ability as yet not investigated in this population: recognition of facial emotion and its association with social gaze.
   Methods: Nine individuals with callosal agenesis and nine matched controls completed four tasks involving emotional faces: emotion recognition from upright and inverted faces, gender recognition, and passive viewing. Eye-tracking data were collected concurrently on all four tasks and analyzed according to designated facial regions of interest.
   Results: Individuals with callosal agenesis exhibited impairments in recognizing emotions from upright faces, in particular lower accuracy for fear and anger, and these impairments were directly associated with diminished attention to the eye region. The callosal agenesis group exhibited greater consistency in emotion recognition across conditions (upright vs. inverted), with poorest performance for fear identification in both conditions. The callosal agenesis group also had atypical facial scanning (lower fractional dwell time in the eye region) during gender naming and passive viewing of faces, but they did not differ from controls on gender naming performance. The pattern of results did not differ when taking into account full-scale intelligence quotient or presence of autism spectrum symptoms.
   Conclusions: Agenesis of the corpus callosum results in a pattern of atypical facial scanning characterized by diminished attention to the eyes. This pattern suggests that reduced callosal connectivity may contribute to the development and maintenance of emotion processing deficits involving reduced attention to others' eyes.
C1 [Bridgman, Matthew W.] DuBois Reg Med Ctr, Du Bois, PA 15801 USA.
   [Brown, Warren S.] Fuller Theol Seminary, Travis Res Inst, Pasadena, CA 91101 USA.
   [Spezio, Michael L.; Adolphs, Ralph; Paul, Lynn K.] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
   [Spezio, Michael L.] Scripps Coll, Claremont, CA 91711 USA.
   [Leonard, Matthew K.] Univ Calif San Francisco, San Francisco, CA 94117 USA.
   [Adolphs, Ralph] CALTECH, Div Biol, Pasadena, CA 91125 USA.
RP Paul, LK (reprint author), CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
EM lkpaul@hss.caltech.edu
FU Pfeiffer Foundation; Simons Foundation; Travis Research Institute
FX This research was supported in part by the Pfeiffer Foundation, the
   Simons Foundation, and the Travis Research Institute. The authors would
   like to thank Candace Markley for her contributions in data management.
CR Aboitiz F, 1992, Biol Res, V25, P51
   Adolphs R, 2000, NEUROPSYCHOLOGY
   Adolphs R, 2000, J NEUROSCI, V20, P2683
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
   Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
   [Anonymous], 1999, WASI ADM SCOR MAN
   Badaruddin DH, 2007, CHILD PSYCHIAT HUM D, V38, P287, DOI 10.1007/s10578-007-0065-6
   Banich MT, 2000, DEV NEUROPSYCHOL, V18, P1, DOI 10.1207/S15326942DN1801_1
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Bediou B, 2005, CAN J PSYCHIAT, V50, P525
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Bogen J, 1985, HDB CLIN NEUROLOGY, V45, P99
   Bogen J, 1979, CLIN NEUROPSYCHOLOGY, P308
   Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x
   Booth R, 2011, PROG BRAIN RES, V189, P303, DOI 10.1016/B978-0-444-53884-0.00031-2
   Borod Joan C, 2002, Appl Neuropsychol, V9, P23, DOI 10.1207/S15324826AN0901_4
   Borod JC, 1998, NEUROPSYCHOLOGY, V12, P446, DOI 10.1037//0894-4105.12.3.446
   BOROD JC, 1992, J CONSULT CLIN PSYCH, V60, P339, DOI 10.1037/0022-006X.60.3.339
   Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
   Brown WS, 2005, BRAIN LANG, V93, P135, DOI 10.1016/j.bandl.2004.09.003
   Brown WS, 2005, NEUROPSYCHOLOGIA, V43, P906, DOI 10.1016/j.neuropsychologia.2004.09.008
   Brown WS, 1999, NEUROPSYCHOLOGIA, V37, P1165, DOI 10.1016/S0028-3932(99)00011-1
   BUCHANAN DC, 1980, PSYCHOTHER PSYCHOSOM, V34, P248
   Chambon V, 2006, NEUROPSYCHOLOGIA, V44, P2437, DOI 10.1016/j.neuropsychologia.2006.04.008
   Cornelissen FW, 2002, BEHAV RES METH INS C, V34, P613, DOI 10.3758/BF03195489
   Davidson RJ, 2003, PSYCHOPHYSIOLOGY, V40, P655, DOI 10.1111/1469-8986.00067
   Eckstein K, 2006, J COGNITIVE NEUROSCI, V18, P1696, DOI 10.1162/jocn.2006.18.10.1696
   Eckstein K, 2005, COGNITIVE BRAIN RES, V25, P130, DOI 10.1016/j.cogbrainres.2005.05.003
   Ekman P., 1976, PICTURES FACIAL AFFE
   Friederici AD, 2004, BRAIN LANG, V89, P267, DOI 10.1016/S0093-934X(03)00351-1
   Huber-Okrainec J, 2005, BRAIN LANG, V93, P349, DOI 10.1016/j.bandl.2004.11.002
   Josse G, 2004, BRAIN RES REV, V44, P1, DOI 10.1016/j.brainresrev.2003.10.001
   Kennedy DP, 2012, NEUROPSYCHOLOGIA, V50, P3313, DOI 10.1016/j.neuropsychologia.2012.09.038
   Kilian S, 2008, DEV NEUROPSYCHOL, V33, P74, DOI 10.1080/87565640701729821
   Kliemann D, 2010, J NEUROSCI, V30, P12281, DOI 10.1523/JNEUROSCI.0688-10.2010
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kuschner ES, 2009, AUTISM RES, V2, P348, DOI 10.1002/aur.101
   Lahaie A, 2006, NEUROPSYCHOLOGY, V20, P30, DOI 10.1037/0894-4105.20.1.30
   Lau YC, 2013, J AUTISM DEV DISORD, V43, P1106, DOI 10.1007/s10803-012-1653-2
   Moes P, 2009, PHYS MOTOR SENSORY D
   Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
   OBRIEN G, 1994, CALLOSAL AGENESIS NA, V42, P235
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Paul LK, 2004, ARCH CLIN NEUROPSYCH, V19, P215, DOI 10.1016/S0887-6177(03)00024-6
   Paul LK, 2007, NAT REV NEUROSCI, V8, P287, DOI 10.1038/nrn2107
   Paul LK, 2014, BRAIN, V137, P1813, DOI 10.1093/brain/awu070
   Paul LK, 2003, BRAIN LANG, V85, P313, DOI 10.1016/S0093-934X(03)00062-2
   Paul LK, 2006, INT J PSYCHOPHYSIOL, V61, P47, DOI 10.1016/j.ijpsycho.2005.10.017
   Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
   Piven J, 1997, AM J PSYCHIAT, V154, P1051
   Pujol J, 1999, NEUROLOGY, V52, P1038
   SANDERS RJ, 1989, BRAIN LANG, V37, P59, DOI 10.1016/0093-934X(89)90101-6
   Schwartz Barbara L, 2002, Cogn Neuropsychiatry, V7, P15, DOI 10.1080/13546800143000113
   Smith MJL, 2010, NEUROPSYCHOLOGIA, V48, P2777, DOI 10.1016/j.neuropsychologia.2010.03.008
   Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
   Streit M, 1997, SCHIZOPHR RES, V24, P311, DOI 10.1016/S0920-9964(96)00126-0
   Symington SH, 2010, SOC NEUROSCI-UK, V5, P296, DOI 10.1080/17470910903462419
   Szaflarski JP, 2012, BRAIN RES, V1433, P85, DOI 10.1016/j.brainres.2011.11.026
   TEMPLE CM, 1989, BRAIN LANG, V37, P548, DOI 10.1016/0093-934X(89)90111-9
   TEMPLE CM, 1993, CORTEX, V29, P341
   Turk AA, 2010, NEUROPSYCHOLOGIA, V48, P43, DOI 10.1016/j.neuropsychologia.2009.08.009
   Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0
   ZAIDEL D, 1977, NEUROPSYCHOLOGIA, V15, P193, DOI 10.1016/0028-3932(77)90028-8
NR 66
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD AUG 14
PY 2014
VL 6
AR 32
DI 10.1186/1866-1955-6-32
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AW1DO
UT WOS:000346031000001
PM 25705318
ER

PT J
AU Oberman, LM
   Pascual-Leone, A
   Rotenberg, A
AF Oberman, Lindsay M.
   Pascual-Leone, Alvaro
   Rotenberg, Alexander
TI Modulation of corticospinal excitabilty by transcranial magnetic
   stimulation in children and adolescents with autism spectrum disorder
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorders; transcranial magnetic stimulation;
   development; plasticity; GABA; theta burst stimulation
ID THETA-BURST STIMULATION; HUMAN MOTOR CORTEX; CORTICAL INHIBITION;
   FUTURE-DIRECTIONS; ASPERGER-SYNDROME; POSTURAL CONTROL; IN-VIVO; GABA;
   BRAIN; MODEL
AB The developmental pathophysiology of autism spectrum disorders (ASD) is currently not fully understood. However, multiple lines of evidence suggest that the behavioral phenotype may result from dysfunctional inhibitory control over excitatory synaptic plasticity. Consistent with this claim, previous studies indicate that adults with Asperger's Syndrome show an abnormally extended modulation of corticospinal excitability following a train of repetitive transcranial magnetic stimulation (rTMS). As ASD is a developmental disorder, the current study aimed to explore the effect of development on the duration of modulation of corticospinal excitability in children and adolescents with ASD. Additionally, as the application of rTMS to the understanding and treatment of pediatric neurological and psychiatric disorders is an emerging field, this study further sought to provide evidence for the safety and tolerability of rTMS in children and adolescents with ASD. Corticospinal excitability was measured by applying single pulses of TMS to the primary motor cortex both before and following a 40 s train of continuous theta burst stimulation. 19 high-functioning males ages 9-18 with ASD participated in this study. Results from this study reveal a positive linear relationship between age and duration of modulation of rTMS aftereffects. Specifically we found that the older participants had a longer lasting response. Furthermore, though the specific protocol employed typically suppresses corticospinal excitability in adults, more than one third of our sample had a paradoxical facilitatory response to the stimulation. Results support the safety and tolerability of rTMS in pediatric clinical populations. Data also support published theories implicating aberrant plasticity and GABAergic dysfunction in this population.
C1 [Oberman, Lindsay M.; Pascual-Leone, Alvaro; Rotenberg, Alexander] Harvard Univ, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Sch Med,Dept Neurol, Boston, MA 02215 USA.
   [Oberman, Lindsay M.; Rotenberg, Alexander] Harvard Univ, Sch Med, Dept Neurol, Neuromodulat Program,Boston Childrens Hosp, Boston, MA 02115 USA.
   [Oberman, Lindsay M.; Rotenberg, Alexander] Harvard Univ, Sch Med, Boston Childrens Hosp, Div Epilepsy & Clin Neurophysiol,Dept Neurol, Boston, MA 02115 USA.
   [Oberman, Lindsay M.] EP Bradley Hosp, Neuroplast & Autism Spectrum Disorder Program, East Providence, RI 02915 USA.
   [Oberman, Lindsay M.] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, East Providence, RI USA.
RP Oberman, LM (reprint author), EP Bradley Hosp, Neuroplast & Autism Spectrum Disorder Program, 1011 Vet Mem Pkwy, East Providence, RI 02915 USA.
EM loberman@lifespan.org; alexander.rotenberg@childrens.harvard.edu
FU Boston Children's Hospital Translational Research Program; National
   Institutes of Health and National Institute of Mental Health
   [1R01MH100186]; Harvard Catalyst; Harvard Clinical and Translational
   Science Center; NCRR; WAITS NIH [8KL2TR000168-05]; Harvard Clinical and
   Translational Science Center [8UL1TR000170-05]; Epilepsy Research
   Foundation; Simons Foundation; Nancy Lurie Marks Family Foundation;
   National Institutes of Health [R01 HD069776, R01NS073601, R21 MH099196,
   R21 NS082870, R21 NS085491, R21 HD07616, UL1 RR025758]; Michael J. Fox
   Foundation; Sidney R. Baer Foundation; Center for Integration of
   Medicine and Innovative Technology (CIMIT); Department of Defense
   [PR121509]; Autism Speaks [48702]; Eisai Inc.; epilepsy therapy project
FX Work on the project is supported grants the Boston Children's Hospital
   Translational Research Program (Alexander Rotenberg), National
   Institutes of Health and National Institute of Mental Health
   (1R01MH100186), and Harvard Catalyst, The Harvard Clinical and
   Translational Science Center (NCRR and the WAITS NIH 8KL2TR000168-05).
   Lindsay M. Oberman is further supported by grants from the Harvard
   Clinical and Translational Science Center (8UL1TR000170-05), the
   Epilepsy Research Foundation, the Simons Foundation and the Nancy Lurie
   Marks Family Foundation, Alvaro Pascual-Leone is further supported by
   grants from the National Institutes of Health (R01 HD069776,
   R01NS073601, R21 MH099196, R21 NS082870, R21 NS085491, R21 HD07616, UL1
   RR025758), Michael J. Fox Foundation and Sidney R. Baer Foundation.
   Alexander Roten berg is further supported by the Center for Integration
   of Medicine and Innovative Technology (CIMIT), Department of Defense
   PR121509, Autism Speaks Grant 48702, and grants from Eisai Inc. and the
   Epilepsy Research Foundation and epilepsy therapy project.
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
   BARKER AT, 1985, LANCET, V1, P1106
   Benali A, 2011, J NEUROSCI, V31, P1193, DOI 10.1523/JNEUROSCI.1379-10.2011
   Ben-Ari Y, 2012, NEUROSCIENTIST, V18, P467, DOI 10.1177/1073858412438697
   Ben-Ari Y, 2007, PHYSIOL REV, V87, P1215, DOI 10.1152/physrev.00017.2006
   Blatt GJ, 2011, ANAT REC, V294, P1646, DOI 10.1002/ar.21252
   Borghetti D, 2008, BRAIN RES BULL, V77, P143, DOI 10.1016/j.brainresbull.2008.06.001
   Cardenas-Morales L, 2011, HUM BRAIN MAPP, V32, P1948, DOI 10.1002/hbm.21160
   Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908
   CHERUBINI E, 1991, TRENDS NEUROSCI, V14, P515, DOI 10.1016/0166-2236(91)90003-D
   Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005
   Croarkin PE, 2011, INT REV PSYCHIATR, V23, P445, DOI 10.3109/09540261.2011.623688
   Enticott PG, 2013, NEUROPHARMACOLOGY, V68, P202, DOI 10.1016/j.neuropharm.2012.06.017
   Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
   Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3
   Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Freitas C, 2011, FRONT AGING NEUROSCI, V3, DOI 10.3389/fnagi.2011.00005
   Frye RE, 2008, J CHILD NEUROL, V23, P79, DOI 10.1177/0883073807307972
   Gaetz W, 2014, NEUROIMAGE, V86, P1, DOI 10.1016/j.neuroimage.2013.05.068
   Garvey MA, 2004, EUR J PAEDIATR NEURO, V8, P7, DOI 10.1016/j.ejpn.2003.11.002
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
   Hallett M, 2007, NEURON, V55, P187, DOI 10.1016/j.neuron.2007.06.026
   Huang YZ, 2008, CEREB CORTEX, V18, P563, DOI 10.1093/cercor/bhm087
   Huang YZ, 2005, NEURON, V45, P201, DOI 10.1016/j.neuron.2004.12.033
   Huang ZJ, 2009, J PHYSIOL-LONDON, V587, P1881, DOI 10.1113/jphysiol.2008.168211
   Huerta PT, 2009, J NEUROENG REHABIL, V6, DOI 10.1186/1743-0003-6-7
   Huttenlocher P. R., 2002, NEURAL PLASTICITY
   Kobayashi M, 2003, LANCET NEUROL, V2, P145, DOI 10.1016/S1474-4422(03)00321-1
   KOHENRAZ R, 1992, J AUTISM DEV DISORD, V22, P419, DOI 10.1007/BF01048244
   Lemonnier E, 2010, ACTA PAEDIATR, V99, P1885, DOI 10.1111/j.1651-2227.2010.01933.x
   Madsen Karsten K., 2008, V44, P201, DOI 10.1007/400_2007_036
   Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
   Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
   Marrosu F, 1987, Funct Neurol, V2, P355
   MAZIERE M, 1984, INT J APPL RADIAT IS, V35, P973, DOI 10.1016/0020-708X(84)90215-1
   Mescher M, 1998, NMR BIOMED, V11, P266, DOI 10.1002/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J
   Minshew NJ, 2004, NEUROLOGY, V63, P2056
   Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
   Mostofsky SH, 2011, NEUROSCIENTIST, V17, P437, DOI 10.1177/1073858410392381
   Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
   Oberman L, 2012, EUR J NEUROSCI, V36, P2782, DOI 10.1111/j.1460-9568.2012.08172.x
   Oberman L. M., PLASTICITY COGNITION
   OBERMAN LM, 2010, J VIS EXP, DOI DOI 10.3791/2272
   OBERMAN LM, 2013, J AUTISM DEV DISORD, DOI DOI 10.1007/S10803-013-1960-1962
   Pascual-Leone A, 2011, BRAIN TOPOGR, V24, P302, DOI 10.1007/s10548-011-0196-8
   Petroff OAC, 2002, NEUROSCIENTIST, V8, P562, DOI 10.1177/1073858402238515
   Rajapakse T, 2013, TRANSL NEUROSCI, V4, P217, DOI 10.2478/s13380-013-0116-3
   Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Selemon LD, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.7
   Stagg CJ, 2009, J NEUROPHYSIOL, V101, P2872, DOI 10.1152/jn.91060.2008
   SUTOR B, 1995, PERSPECT DEV NEUROBI, V2, P409
   Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
   Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
   Thickbroom GW, 2007, EXP BRAIN RES, V180, P583, DOI 10.1007/s00221-007-0991-3
   Tyzio R, 2014, SCIENCE, V343, P675, DOI 10.1126/science.1247190
   Walther M, 2009, BRAIN DEV-JPN, V31, P562, DOI 10.1016/j.braindev.2009.02.007
   Wu SW, 2012, DEV MED CHILD NEUROL, V54, P636, DOI 10.1111/j.1469-8749.2012.04300.x
   Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
   Ziemann U, 2004, REV NEUROSCIENCE, V15, P253
NR 61
TC 3
Z9 3
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD AUG 13
PY 2014
VL 8
AR 627
DI 10.3389/fnhum.2014.00627
PG 8
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AN6YF
UT WOS:000340744000001
PM 25165441
ER

PT J
AU Adamsen, D
   Ramaekers, V
   Ho, HTB
   Britschgi, C
   Rufenacht, V
   Meili, D
   Bobrowski, E
   Philippe, P
   Nava, C
   Van Maldergem, L
   Bruggmann, R
   Walitza, S
   Wang, J
   Grunblatt, E
   Thony, B
AF Adamsen, Dea
   Ramaekers, Vincent
   Ho, Horace T. B.
   Britschgi, Corinne
   Ruefenacht, Veronique
   Meili, David
   Bobrowski, Elise
   Philippe, Paule
   Nava, Caroline
   Van Maldergem, Lionel
   Bruggmann, Remy
   Walitza, Susanne
   Wang, Joanne
   Gruenblatt, Edna
   Thoeny, Beat
TI Autism spectrum disorder associated with low serotonin in CSF and
   mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT)
   gene
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; Serotonin end-metabolite 5-hydroxyindolacetic
   acid; SERT; PMAT
ID 1ST-DEGREE RELATIVES; BRAIN-DEVELOPMENT; NEURONS; DISRUPTION; BEHAVIORS;
   CHILDREN
AB Background: Patients with autism spectrum disorder (ASD) may have low brain serotonin concentrations as reflected by the serotonin end-metabolite 5-hydroxyindolacetic acid (5HIAA) in cerebrospinal fluid (CSF).
   Methods: We sequenced the candidate genes SLC6A4 (SERT), SLC29A4 (PMAT), and GCHFR (GFRP), followed by whole exome analysis.
   Results: The known heterozygous p.Gly56Ala mutation in the SLC6A4 gene was equally found in the ASD and control populations. Using a genetic candidate gene approach, we identified, in 8 patients of a cohort of 248 with ASD, a high prevalence (3.2%) of three novel heterozygous non-synonymous mutations within the SLC29A4 plasma membrane monoamine transporter (PMAT) gene, c.86A > G (p.Asp29Gly) in two patients, c.412G > A (p.Ala138Thr) in five patients, and c.978 T > G (p.Asp326Glu) in one patient. Genome analysis of unaffected parents confirmed that these PMAT mutations were not de novo but inherited mutations. Upon analyzing over 15,000 normal control chromosomes, only SLC29A4 c.86A > G was found in 23 alleles (0.14%), while neither c.412G > A (<0.007%) nor c.978 T > G (<0.007%) were observed in all chromosomes analyzed, emphasizing the rareness of the three alterations. Expression of mutations PMAT-p.Ala138Thr and p.Asp326Glu in cellulae revealed significant reduced transport uptake activity towards a variety of substrates including serotonin, dopamine, and 1-methyl-4-phenylpyridinium (MPP+), while mutation p.Asp29Gly had reduced transport activity only towards MPP+. At least two ASD subjects with either the PMAT-Ala138Thr or the PMAT-Asp326Glu mutation with altered serotonin transport activity had, besides low 5HIAA in CSF, elevated serotonin levels in blood and platelets. Moreover, whole exome sequencing revealed additional alterations in these two ASD patients in mainly serotonin-homeostasis genes compared to their non-affected family members.
   Conclusions: Our findings link mutations in SLC29A4 to the ASD population although not invariably to low brain serotonin. PMAT dysfunction is speculated to raise serotonin prenatally, exerting a negative feedback inhibition through serotonin receptors on development of serotonin networks and local serotonin synthesis. Exome sequencing of serotonin homeostasis genes in two families illustrated more insight in aberrant serotonin signaling in ASD.
C1 [Adamsen, Dea; Ruefenacht, Veronique; Thoeny, Beat] Univ Zurich, Dept Pediat, Div Metab, CH-8032 Zurich, Switzerland.
   [Adamsen, Dea; Walitza, Susanne; Gruenblatt, Edna; Thoeny, Beat] Univ Zurich, Neurosci Ctr Zurich, CH-8000 Zurich, Switzerland.
   [Adamsen, Dea; Walitza, Susanne; Gruenblatt, Edna; Thoeny, Beat] ETH Zurich ZNZ, CH-8000 Zurich, Switzerland.
   [Adamsen, Dea; Thoeny, Beat] Childrens Res Ctr CRC, CH-8032 Zurich, Switzerland.
   [Ramaekers, Vincent; Philippe, Paule] Univ Hosp Liege, Ctr Autism Liege, B-4000 Liege, Belgium.
   [Ramaekers, Vincent; Philippe, Paule] Univ Hosp Liege, Div Pediat Neurol, B-4000 Liege, Belgium.
   [Ho, Horace T. B.; Wang, Joanne] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA.
   [Britschgi, Corinne; Meili, David; Thoeny, Beat] Univ Zurich, Dept Pediat, Div Clin Chem & Biochem, CH-8032 Zurich, Switzerland.
   [Bobrowski, Elise; Walitza, Susanne; Gruenblatt, Edna] Univ Zurich, Univ Clin Child & Adolescent Psychiat, CH-8050 Zurich, Switzerland.
   [Nava, Caroline] Hop La Pitie Salpetriere, Dept Genet Cytogenet & Human Genet, F-75651 Paris, France.
   [Van Maldergem, Lionel] Univ Franche Comte, Ctr Human Genet, F-25030 Besancon, France.
   [Bruggmann, Remy] Univ Zurich, ETH Zurich, Funct Genom Ctr Zurich, CH-8057 Zurich, Switzerland.
   [Walitza, Susanne; Thoeny, Beat] Univ Zurich, Zurich Ctr Integrat Human Physiol ZIHP, CH-8000 Zurich, Switzerland.
RP Thony, B (reprint author), Univ Zurich, Dept Pediat, Div Metab, CH-8032 Zurich, Switzerland.
EM beat.thony@kispi.uzh.ch
FU "Fonds National de Recherches Scientifiques", Belgium (FNRS)
   [3.4.540.09.F]; Centre for Neuroscience Zurich; Swiss National Science
   Foundation; Novartis "Stiftung fur medizinisch-biologische Forschung";
   National Institutes of Health [GM066233]; University Children's Hospital
   Zurich
FX We thank Anahita Rassi for technical assistance, Nenad Blau for valuable
   discussions, and the University Children's Hospital Zurich for their
   general support. This project was supported by grants from the "Fonds
   National de Recherches Scientifiques", Belgium (FNRS No: 3.4.540.09.F to
   VR), the Centre for Neuroscience Zurich (to BT), the Swiss National
   Science Foundation (to BT), Novartis "Stiftung fur
   medizinisch-biologische Forschung" (to BT), and the National Institutes
   of Health (GM066233 to JW).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Adamsen D, 2011, MOL GENET METAB, V102, P368, DOI 10.1016/j.ymgme.2010.11.162
   Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
   Blau N, 2003, PHYS GUIDE LAB DIAGN, P106
   Boylan CB, 2007, BEHAV BRAIN RES, V176, P94, DOI 10.1016/j.bbr.2006.08.026
   Buitelaar JK, 2000, EUR CHILD ADOLES PSY, V9, P85
   Burgess NK, 2006, J AUTISM DEV DISORD, V36, P697, DOI 10.1007/s10803-006-0100-7
   Castermans D, 2010, HUM MOL GENET, V19, P1368, DOI 10.1093/hmg/ddq013
   Chugani DC, 1997, ANN NEUROL, V42, P666, DOI 10.1002/ana.410420420
   Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
   Chugani DC, 2002, MOL PSYCHIATR, V7, pS16, DOI 10.1038/sj.mp.4001167
   Cross S, 2008, NEUROPSYCHOPHARMACOL, V33, P353, DOI 10.1038/sj.npp.1301406
   Dahlin A, 2007, NEUROSCIENCE, V146, P1193, DOI 10.1016/j.neuroscience.2007.01.072
   Daws LC, 2009, PHARMACOL THERAPEUT, V121, P89, DOI 10.1016/j.pharmthera.2008.10.004
   De Grandis E, 2010, J INHERIT METAB DIS, V33, P803, DOI 10.1007/s10545-010-9200-9
   Dougherty JD, 2013, J NEUROSCI, V33, P2732, DOI 10.1523/JNEUROSCI.4762-12.2013
   Duan HC, 2013, J BIOL CHEM, V288, P3535, DOI 10.1074/jbc.M112.436972
   Engel K, 2004, J BIOL CHEM, V279, P50042, DOI 10.1074/jbc.M407913200
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hendricks TJ, 2003, NEURON, V37, P233, DOI 10.1016/S0896-6273(02)01167-4
   Huang CH, 2008, AM J MED GENET B, V147B, P903, DOI 10.1002/ajmg.b.30720
   Kane MJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048975
   Kapatos G, 1999, J NEUROCHEM, V72, P669, DOI 10.1046/j.1471-4159.1999.0720669.x
   Kurian MA, 2011, LANCET NEUROL, V10, P721, DOI 10.1016/S1474-4422(11)70141-7
   Leabman MK, 2003, P NATL ACAD SCI USA, V100, P5896, DOI 10.1073/pnas.0730857100
   Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Maloney SE, 2013, INT REV NEUROBIOL, V113, P61, DOI 10.1016/B978-0-12-418700-9.00003-4
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Murphy DL, 2004, MOL INTERV, V4, P109, DOI 10.1124/mi.4.2.8
   Ramaekers VT, 2001, MOL GENET METAB, V73, P179, DOI 10.1006/mgme.2001.3187
   Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
   Scott MM, 2005, INT J DEV NEUROSCI, V23, P277, DOI 10.1016/j.ijdevneu.2004.05.012
   Stoner R, 2014, NEW ENGL J MED, V370, P1209, DOI 10.1056/NEJMoa1307491
   Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
   Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
   Tietz N., 2001, FUNDAMENTALS CLIN CH
   Veenstra-VanderWeele J, 2009, J NEURODEV DISORD, V1, P158, DOI 10.1007/s11689-009-9020-0
   Vialou V, 2007, NEUROSCIENCE, V144, P616, DOI 10.1016/j.neuroscience.2006.09.058
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3
   Whitaker-Azmitia PM, 2005, INT J DEV NEUROSCI, V23, P75, DOI 10.1016/j.ijdevneu.2004.07.022
   Zhou MY, 2007, BIOCHEM PHARMACOL, V73, P147, DOI 10.1016/j.bcp.2006.09.008
   Zhou MY, 2007, J BIOL CHEM, V282, P3188, DOI 10.1074/jbc.M609421200
NR 45
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD AUG 13
PY 2014
VL 5
AR 43
DI 10.1186/2040-2392-5-43
PG 11
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AO2NA
UT WOS:000341159100001
PM 25802735
ER

PT J
AU Gimelli, S
   Capra, V
   Di Rocco, M
   Leoni, M
   Mirabelli-Badenier, M
   Schiaffino, MC
   Fiorio, P
   Cuoco, C
   Gimelli, G
   Tassano, E
AF Gimelli, Stefania
   Capra, Valeria
   Di Rocco, Maja
   Leoni, Massimiliano
   Mirabelli-Badenier, Marisol
   Schiaffino, Maria Cristina
   Fiorio, Patrizia
   Cuoco, Cristina
   Gimelli, Giorgio
   Tassano, Elisa
TI Interstitial 7q31.1 copy number variations disrupting IMMP2L gene are
   associated with a wide spectrum of neurodevelopmental disorders
SO MOLECULAR CYTOGENETICS
LA English
DT Article
DE IMMP2L; Neurodevelopmental disorders; Copy number variation; Array-CGH
ID TOURETTE-SYNDROME; MITOCHONDRIAL DYSFUNCTION; AUTISM; ACTIVATION;
   BREAKPOINT; MUTATION
AB Background: Since the introduction of the array-CGH technique in the diagnostic workup of mental retardation, new recurrent copy number variations and novel microdeletion/microduplication syndromes were identified. These findings suggest that some genomic disorders have high penetrance but a wide range of phenotypic severity.
   Results: We present the clinical and molecular description of four unrelated patients affected by neurodevelopmental disorders and overlapping 7q31.1 microdeletion/microduplication, identified by array-CGH and involving only part of the IMMP2L gene.
   Conclusion: IMMP2L encodes an inner mitochondrial membrane protease-like protein, which is required for processing of cytochromes inside mitochondria. Numerous studies reported that this gene is implicated in behavioural disorders such as autistic spectrum disorders, attention-deficit hyperactivity disorders, and Gilles de la Tourette syndrome. We discuss the functions of the gene suggesting that IMMP2L may act as risk factor for neurological disease.
C1 [Gimelli, Stefania] Univ Hosp Geneva, Serv Genet Med, Geneva, Switzerland.
   [Capra, Valeria] Ist Giannina Gaslini, UO Neurochirurg, I-16147 Genoa, Italy.
   [Di Rocco, Maja] Ist Giannina Gaslini, USD Malattie Rare, I-16147 Genoa, Italy.
   [Leoni, Massimiliano] Ist Giannina Gaslini, I-16147 Genoa, Italy.
   [Mirabelli-Badenier, Marisol] Univ Genoa, DINOMGI Dipartimento, Genoa, Italy.
   [Schiaffino, Maria Cristina] Ist Giannina Gaslini, Dipartimento Pediat, Genoa, Italy.
   [Fiorio, Patrizia; Cuoco, Cristina; Gimelli, Giorgio; Tassano, Elisa] Ist Giannina Gaslini, Lab Citogenet, I-16147 Genoa, Italy.
RP Tassano, E (reprint author), Ist Giannina Gaslini, Lab Citogenet, I-16147 Genoa, Italy.
EM eli.tassano@gmail.com
FU Cinque per mille dell'IRPEF-Finanziamento della ricerca sanitaria;
   Finanziamento Ricerca Corrente, Ministero Salute (contributo per la
   ricerca intramurale)
FX We thank the patient's parents for their kind participation and support.
   We are grateful to Marco Bertorello and Corrado Torello for their
   technical assistance. This work was supported by "Cinque per mille
   dell'IRPEF-Finanziamento della ricerca sanitaria" and "Finanziamento
   Ricerca Corrente, Ministero Salute" (contributo per la ricerca
   intramurale).
CR Barateiro A, 2012, NEUROMOL MED, V14, P285, DOI 10.1007/s12017-012-8187-9
   Battye R, 2001, J NEUROSCI, V21, P4290
   Bertelsen B, 2014, EUR J HUM GENET, V19, P1
   Elia J, 2010, MOL PSYCHIATR, V15, P1122, DOI 10.1038/mp.2010.75
   Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x
   Fukamachi K, 2002, J BIOL CHEM, V277, P43549, DOI 10.1074/jbc.C200502200
   Graeber MB, 1998, J NEUROL SCI, V153, P251, DOI 10.1016/S0022-510X(97)00295-5
   Leonard JV, 2000, LANCET, V355, P389, DOI 10.1016/S0140-6736(99)05226-5
   Lu B, 2008, BIOL REPROD, V78, P601, DOI 10.1095/biolreprod.107.065987
   Ma Y, 2011, NEUROBIOL DIS, V44, P270, DOI 10.1016/j.nbd.2011.06.019
   Maestrini E, 2010, MOL PSYCHIATR, V15, P954, DOI 10.1038/mp.2009.34
   Mattson MP, 2008, NEURON, V60, P748, DOI 10.1016/j.neuron.2008.10.010
   NUNNARI J, 1993, SCIENCE, V262, P1997, DOI 10.1126/science.8266095
   Patel C, 2011, EUR J HUM GENET, V19, P634, DOI 10.1038/ejhg.2010.238
   Petek E, 2001, AM J HUM GENET, V68, P848, DOI 10.1086/319523
   Petek E, 2007, MOL GENET GENOMICS, V277, P71, DOI 10.1007/s00438-006-0173-1
   Rezin GT, 2009, NEUROCHEM RES, V34, P1021, DOI 10.1007/s11064-008-9865-8
   Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
   Whatley SA, 1996, NEUROCHEM RES, V21, P995, DOI 10.1007/BF02532409
NR 19
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8166
J9 MOL CYTOGENET
JI Mol. Cytogenet.
PD AUG 13
PY 2014
VL 7
AR 54
DI 10.1186/s13039-014-0054-y
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AN7TM
UT WOS:000340803500001
PM 25478008
ER

PT J
AU Meilleur, AAS
   Berthiaume, C
   Bertone, A
   Mottron, L
AF Meilleur, Andree-Anne S.
   Berthiaume, Claude
   Bertone, Armando
   Mottron, Laurent
TI Autism-Specific Covariation in Perceptual Performances: "g'' or "p''
   Factor?
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; GENERAL INTELLIGENCE; PITCH
   DISCRIMINATION; GABA CONCENTRATION; ASPERGER SYNDROME; AUDITORY-CORTEX;
   INSPECTION TIME; VISUAL-CORTEX; SENSITIVITY
AB Background: Autistic perception is characterized by atypical and sometimes exceptional performance in several low- (e.g., discrimination) and mid-level (e. g., pattern matching) tasks in both visual and auditory domains. A factor that specifically affects perceptive abilities in autistic individuals should manifest as an autism-specific association between perceptual tasks. The first purpose of this study was to explore how perceptual performances are associated within or across processing levels and/or modalities. The second purpose was to determine if general intelligence, the major factor that accounts for covariation in task performances in non-autistic individuals, equally controls perceptual abilities in autistic individuals.
   Methods: We asked 46 autistic individuals and 46 typically developing controls to perform four tasks measuring low-or mid-level visual or auditory processing. Intelligence was measured with the Wechsler's Intelligence Scale (FSIQ) and Raven Progressive Matrices (RPM). We conducted linear regression models to compare task performances between groups and patterns of covariation between tasks. The addition of either Wechsler's FSIQ or RPM in the regression models controlled for the effects of intelligence.
   Results: In typically developing individuals, most perceptual tasks were associated with intelligence measured either by RPM or Wechsler FSIQ. The residual covariation between unimodal tasks, i.e. covariation not explained by intelligence, could be explained by a modality-specific factor. In the autistic group, residual covariation revealed the presence of a plurimodal factor specific to autism.
   Conclusions: Autistic individuals show exceptional performance in some perceptual tasks. Here, we demonstrate the existence of specific, plurimodal covariation that does not dependent on general intelligence (or "g'' factor). Instead, this residual covariation is accounted for by a common perceptual process (or "p'' factor), which may drive perceptual abilities differently in autistic and non-autistic individuals.
C1 [Meilleur, Andree-Anne S.; Berthiaume, Claude; Bertone, Armando; Mottron, Laurent] Univ Montreal, Hop Riviere Des Prairies, Ctr Excellence Pervas Dev Disorders CETEDUM, Montreal, PQ, Canada.
   [Bertone, Armando] McGill Univ, Sch Appl Child Psychol, Dept Educ & Counselling Psychol, Montreal, PQ, Canada.
RP Mottron, L (reprint author), Univ Montreal, Hop Riviere Des Prairies, Ctr Excellence Pervas Dev Disorders CETEDUM, Montreal, PQ, Canada.
EM laurent.mottron@gmail.com
FU CIHR [171795]; Autism Speaks Foundation [2706]; Frederick Banting and
   Charles Best Canada Graduate Scholarships Doctoral Award (CGS-D)
FX This work was supported by grants from CIHR (171795); Autism Speaks
   Foundation (2706) and the Frederick Banting and Charles Best Canada
   Graduate Scholarships Doctoral Award (CGS-D) (AASM). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Acton GS, 2001, INTELLIGENCE, V29, P263, DOI 10.1016/S0160-2896(01)00066-6
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT, P50
   Barbeau EB, 2013, J ABNORM PSYCHOL, V122, P295, DOI 10.1037/a0029984
   Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
   Bertone A, 2010, J AUTISM DEV DISORD, V40, P1541, DOI 10.1007/s10803-010-1110-z
   Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
   Bhatara A, 2013, J AUTISM DEV DISORD, V43, P2312, DOI 10.1007/s10803-013-1778-y
   Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169
   Bonnel A, 2010, NEUROPSYCHOLOGIA, V48, P2465, DOI 10.1016/j.neuropsychologia.2010.04.020
   Bouvet L, 2014, COGNITION, V131, P367, DOI 10.1016/j.cognition.2014.02.006
   Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
   Conrad R., 1979, DEAF SCHOOLCHILD LAN
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   Edden RAE, 2009, J NEUROSCI, V29, P15721, DOI 10.1523/JNEUROSCI.4426-09.2009
   Falter CM, 2012, J AUTISM DEV DISORD, V43, P1857
   Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Ferster D, 2000, ANNU REV NEUROSCI, V23, P441, DOI 10.1146/annurev.neuro.23.1.441
   Gomes Erissandra, 2008, Pro Fono, V20, P279
   Grudnik JL, 2001, INTELLIGENCE, V29, P523, DOI 10.1016/S0160-2896(01)00078-2
   Perreault A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019519
   Harvey LO, 1997, SPATIAL VISION, V11, P121, DOI 10.1163/156856897X00159
   Hayashi M, 2008, BRAIN COGNITION, V66, P306, DOI 10.1016/j.bandc.2007.09.008
   Heaton P, 2008, COGN NEUROPSYCHOL, V25, P771, DOI 10.1080/02643290802336277
   Heaton P, 2008, AUTISM, V12, P203, DOI 10.1177/1362361307085270
   Jarvinen-Pasley A, 2008, DEVELOPMENTAL SCI, V11, P109, DOI 10.1111/j.1467-7687.2007.00644.x
   Jemel B, 2010, J VISION, V10, DOI 10.1167/10.6.13
   Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015
   Kaldy Z, 2011, DEVELOPMENTAL SCI, V14, P980, DOI 10.1111/j.1467-7687.2011.01053.x
   Keita L, 2014, SCI REP-UK, V4, DOI 10.1038/srep05475
   Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mackintosh N, 2011, IQ HUMAN INTELLIGENC
   McCleery JP, 2007, BIOL PSYCHIAT, V62, P1007, DOI 10.1016/j.biopsych.2007.02.009
   McGrew K. S., 2005, CONT INTELLECTUAL AS, V2<SUP>nd</SUP>, P136
   Melnick MD, 2013, CURR BIOL, V23, P1013, DOI 10.1016/j.cub.2013.04.053
   Micheyl C, 2006, HEARING RES, V219, P36, DOI 10.1016/j.heares.2006.05.004
   Mitchell P, 2010, AUTISM RES, V3, P113, DOI 10.1002/aur.130
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   Mottron L, 2013, NEUROSCI BIOBEHAV R, V37, P209, DOI 10.1016/j.neubiorev.2012.11.016
   Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253
   Pellicano E, 2011, AUTISM RES, V4, P271, DOI 10.1002/aur.201
   PERETZ I, 1987, CORTEX, V23, P317
   Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
   Poulin-Lord MP, 2014, NEUROIMAGE-CLIN, V4, P444, DOI 10.1016/j.nicl.2014.02.008
   Puts NAJ, 2011, J NEUROSCI, V31, P16556, DOI 10.1523/JNEUROSCI.4489-11.2011
   Razak KA, 2010, J NEUROPHYSIOL, V104, P517, DOI 10.1152/jn.00294.2010
   Razak KA, 2009, J NEUROPHYSIOL, V102, P1366, DOI 10.1152/jn.00334.2009
   Remington AM, 2012, J ABNORM PSYCHOL, V121, P544, DOI 10.1037/a0027670
   Samson F, 2012, HUM BRAIN MAPP, V33, P1553, DOI 10.1002/hbm.21307
   Schwarzkopf DS, 2014, J NEUROSCI, V34, P2713, DOI 10.1523/JNEUROSCI.4416-13.2014
   Sinclair J., 1999, WHY I DISLIKE PERSON
   Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831
   Spearman C, 1904, AM J PSYCHOL, V15, P201, DOI 10.2307/1412107
   Stevenson JL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059329
   Tervaniemi M, 2009, EUR J NEUROSCI, V30, P1636, DOI 10.1111/j.1460-9568.2009.06955.x
   Vattikuti S, 2010, BIOL PSYCHIAT, V67, P672, DOI 10.1016/j.biopsych.2009.09.008
   Vlamings PHJM, 2010, BIOL PSYCHIAT, V68, P1107, DOI 10.1016/j.biopsych.2010.06.024
   WEIBULL W, 1951, J APPL MECH-T ASME, V18, P293
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
   Zwaigenbaum L, 2010, CURR OPIN NEUROL, V23, P97, DOI 10.1097/WCO.0b013e3283372430
NR 63
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2014
VL 9
IS 8
AR e103781
DI 10.1371/journal.pone.0103781
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO3LJ
UT WOS:000341230400023
PM 25117450
ER

PT J
AU Calderon-Garciduenas, L
   Torres-Jardon, R
   Kulesza, RJ
   Park, SB
   D'Angiulli, A
AF Calderon-Garciduenas, Lilian
   Torres-Jardon, Ricardo
   Kulesza, Randy J.
   Park, Su-Bin
   D'Angiulli, Amedeo
TI Air pollution and detrimental effects on children's brain. The need for
   a multidisciplinary approach to the issue complexity and challenges
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE urban children; air pollution; cognition; brain volumetric changes;
   white matter hyperintensities; cytokines; Alzheimer; Parkinson
ID PARTICULATE MATTER; SYSTEMIC INFLAMMATION; SUPERIOR OLIVE; MEXICO-CITY;
   EXPOSURE; AUTISM; HEALTH; NANOPARTICLES; COGNITION; RISK
AB Millions of children in polluted cities are showing brain detrimental effects. Urban children exhibit brain structural and volumetric abnormalities, systemic inflammation, olfactory, auditory, vestibular and cognitive deficits v low-pollution controls. Neuroinflammation and blood-brain-barrier (BBB) breakdown target the olfactory bulb, prefrontal cortex and brainstem, but are diffusely present throughout the brain. Urban adolescent Apolipoprotein E4 carriers significantly accelerate Alzheimer pathology. Neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation and neurodegeneration forces to employ a weight of evidence approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiological research. Pediatric air pollution research requires extensive multidisciplinary collaborations to accomplish a critical goal: to protect exposed children through multidimensional interventions having both broad impact and reach. Protecting children and teens from neural effects of air pollution should be of pressing importance for public health.
C1 [Calderon-Garciduenas, Lilian] Univ Montana, Ctr Struct & Funct Neurosci, Dept Biomed Sci, Missoula, MT 59812 USA.
   [Torres-Jardon, Ricardo] Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Mexico City 04510, DF, Mexico.
   [Kulesza, Randy J.] Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA USA.
   [Park, Su-Bin; D'Angiulli, Amedeo] Carleton Univ, NICER Lab, Neurosci Imagery Cognit & Emot Res Lab, Ottawa, ON K1S 5B6, Canada.
RP D'Angiulli, A (reprint author), Carleton Univ, NICER Lab, Neurosci Imagery Cognit & Emot Res Lab, IIS, 1125 Colonel Dr,Dunton Tower,Room 2202A, Ottawa, ON K1S 5B6, Canada.
EM amedeo@connect.carleton.ca
CR Adamkiewicz G, 2011, AM J PUBLIC HEALTH, V101, pS238, DOI 10.2105/AJPH.2011.300119
   Amato F, 2014, SCI TOTAL ENVIRON, V490, P757, DOI 10.1016/j.scitotenv.2014.05.051
   Amram O, 2011, INT J HEALTH GEOGR, V10, DOI 10.1186/1476-072X-10-68
   Barbieri E, 2014, SCI TOTAL ENVIRON, V487, P13, DOI 10.1016/j.scitotenv.2014.03.136
   Becerra TA, 2013, ENVIRON HEALTH PERSP, V121, P380, DOI 10.1289/ehp.1205827
   Block ML, 2012, NEUROTOXICOLOGY, V33, P972, DOI 10.1016/j.neuro.2012.08.014
   Borges G, 2011, REV PANAM SALUD PUBL, V30, P477
   Braak H, 2011, ACTA NEUROPATHOL, V121, P171, DOI 10.1007/s00401-010-0789-4
   Brook RD, 2010, CIRCULATION, V121, P2331, DOI 10.1161/CIR.0b013e3181dbece1
   Brun E, 2012, BIOMATERIALS, V33, P886, DOI 10.1016/j.biomaterials.2011.10.025
   Caldera-Alvarado G, 2013, ALLERGY, V68, P545, DOI 10.1111/all.12125
   Calderon-Garciduenas L, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00183
   Calderon-Garciduenas L, 2003, PEDIATR PULM, V36, P148, DOI 10.1002/ppul.10338
   CALDERONGARCIDUENAS L, 1992, AM J PATHOL, V140, P225
   Calderon-Garciduenas L, 2011, INT J DEV NEUROSCI, V29, P365, DOI 10.1016/j.ijdevneu.2011.03.007
   Calderon-Garciduenas L, 2011, BRAIN COGNITION, V77, P345, DOI 10.1016/j.bandc.2011.09.006
   Calderon-Garciduenas L, 2008, BRAIN COGNITION, V68, P117, DOI 10.1016/j.bandc.2008.04.008
   Calderon-Garciduenas L, 2007, ENVIRON HEALTH PERSP, V115, P1248, DOI 10.1289/ehp.9641
   Calderon-Garciduenas L, 2012, J ALZHEIMERS DIS, V31, P183, DOI 10.3233/JAD-2012-120610
   Calderon-Garciduenas L, 2012, J ALZHEIMERS DIS, V28, P93, DOI 10.3233/JAD-2011-110722
   Everett Jones Sherry, 2010, J Sch Health, V80, P280, DOI 10.1111/j.1746-1561.2010.00502.x
   Fonken LK, 2011, MOL PSYCHIATR, V16, P987, DOI 10.1038/mp.2011.76
   Guo L, 2012, J HAZARD MATER, V213, P28, DOI 10.1016/j.jhazmat.2012.01.034
   Guxens M, 2012, SWISS MED WKLY, V141, DOI 10.4414/smw.2011.13322
   Haynes EN, 2011, ENVIRON RES, V111, P1243, DOI 10.1016/j.envres.2011.08.008
   Jian H., 2012, ACTA NEUROL BELG, DOI [10.1007/s13760-012-0154-6, DOI 10.1007/S13760-012-0154-6]
   Kotkin J., 2014, FORBES
   Kulesza RJ, 2008, BRAIN RES, V1200, P132, DOI 10.1016/j.brainres.2008.01.009
   Kulesza RJ, 2011, BRAIN RES, V1367, P360, DOI 10.1016/j.brainres.2010.10.015
   Larsson M, 2009, NEUROTOXICOLOGY, V30, P822, DOI 10.1016/j.neuro.2009.01.011
   Levesque S, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-105
   Linsinger TPJ, 2013, FOOD CHEM, V138, P1959, DOI 10.1016/j.foodchem.2012.11.074
   Liu JH, 2011, AGGRESS VIOLENT BEH, V16, P63, DOI 10.1016/j.avb.2010.12.003
   Liu JH, 2014, J ENVIRON HEALTH, V76, P130
   Lukose R, 2013, AUTISM RES, V6, P344, DOI 10.1002/aur.1297
   Mohai P, 2011, HEALTH AFFAIR, V30, P852, DOI 10.1377/hlthaff.2011.0077
   National Institute of Aging National Institutes of Health and World Health Organization, 2001, GLOB HLTH AG
   Newman NC, 2013, ENVIRON HEALTH PERSP, V121, P731, DOI 10.1289/ehp.1205555
   Paul D, 2013, MICROVASC RES, V86, P1, DOI 10.1016/j.mvr.2012.12.001
   Perera F, 2014, J PUBLIC HEALTH POL, V35, P327, DOI 10.1057/jphp.2014.14
   Roher Alex E, 2012, Vasc Health Risk Manag, V8, P599, DOI 10.2147/VHRM.S34874
   Sampson N, 2012, J SCHOOL HEALTH, V82, P246, DOI 10.1111/j.1746-1561.2012.00694.x
   Schroder N, 2013, J ALZHEIMERS DIS, V34, P797, DOI 10.3233/JAD-121996
   Siddique S, 2011, EUR J PEDIATR, V170, P923, DOI 10.1007/s00431-010-1379-0
   Suglia SF, 2008, AM J EPIDEMIOL, V167, P280, DOI 10.1093/aje/kwm308
   Takahashi Y, 2010, J TOXICOL SCI, V35, P749
   Tang DL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091966
   Umezawa M, 2012, J TOXICOL SCI, V37, P1247
   Villarreal-Calderon A, 2002, ARCH ENVIRON HEALTH, V57, P450
   Volk HE, 2013, JAMA PSYCHIAT, V70, P71, DOI 10.1001/jamapsychiatry.2013.266
   Wright RJ, 2011, AM J RESP CRIT CARE, V184, P752, DOI 10.1164/rccm.201106-1139ED
   Zhang X, 2010, J AUTISM DEV DISORD, V40, P1311, DOI 10.1007/s10803-010-0992-0
NR 52
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD AUG 12
PY 2014
VL 8
AR 613
DI 10.3389/fnhum.2014.00613
PG 7
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AN6NB
UT WOS:000340710100001
PM 25161617
ER

PT J
AU Abney, DH
   Warlaumont, AS
   Haussman, A
   Ross, JM
   Wallot, S
AF Abney, Drew H.
   Warlaumont, Anne S.
   Haussman, Anna
   Ross, Jessica M.
   Wallot, Sebastian
TI Using nonlinear methods to quantify changes in infant limb movements and
   vocalizations
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE motor development; infant vocalization; nonlinear methods; recurrence;
   Allan factor
ID MOTOR DEVELOPMENT; LANGUAGE-DEVELOPMENT; SPONTANEOUS KICKING; UPRIGHT
   LOCOMOTION; SPEECH DEVELOPMENT; COORDINATION; AUTISM; COGNITION;
   CHILDREN; DYNAMICS
AB The pairing of dynamical systems theory and complexity science brings novel concepts and methods to the study of infant motor development. Accordingly, this longitudinal case study presents a new approach to characterizing the dynamics of infant limb and vocalization behaviors. A single infant's vocalizations and limb movements were recorded from 51-days to 305-days of age. On each recording day, accelerometers were placed on all four of the infant's limbs and an audio recorder was worn on the child's chest. Using nonlinear time series analysis methods, such as recurrence quantification analysis and Allan factor, we quantified changes in the stability and multiscale properties of the infant's behaviors across age as well as how these dynamics relate across modalities and effectors. We observed that particular changes in these dynamics preceded or coincided with the onset of various developmental milestones. For example, the largest changes in vocalization dynamics preceded the onset of canonical babbling. The results show that nonlinear analyses can help to understand the functional co-development of different aspects of infant behavior.
C1 [Abney, Drew H.; Warlaumont, Anne S.; Ross, Jessica M.] Univ Calif, Merced, CA USA.
   [Wallot, Sebastian] Aarhus Univ, Dept Culture & Society, Interacting Minds Ctr, Aarhus, Denmark.
RP Abney, DH (reprint author), Univ Calif, Sch Social Sci Humanities & Arts, 5200 North Lake Rd, Merced, CA 95343 USA.
EM drewabney@gmail.com
CR Adolph KE, 2011, DEVELOPMENTAL SCIENCE: AN ADVANCED TEXTBOOK, SIXTH EDITION, P241
   Adolph KE, 2008, PSYCHOL REV, V115, P527, DOI 10.1037/0033-295X.115.3.527
   Adolph KE, 2012, PSYCHOL SCI, V23, P1387, DOI 10.1177/0956797612446346
   ALLAN DW, 1966, PR INST ELECTR ELECT, V54, P221, DOI 10.1109/PROC.1966.4634
   Assmann B, 2007, INFANT BEHAV DEV, V30, P568, DOI 10.1016/j.infbeh.2007.04.004
   Atun-Einy O, 2014, INFANCY, V19, P82, DOI 10.1111/infa.12030
   Bassingthwaighte J. B, 1994, FRACTAL PHYSL, DOI [10.1007/978-1-4614-7572-9, DOI 10.1007/978-1-4614-7572-9]
   Bayley N, 1993, BAYLEY SCALES INFANT
   Bernstein N., 1967, COORDINATION REGULAT
   Bertenthal B, 1998, NEUROSCI BIOBEHAV R, V22, P515, DOI 10.1016/S0149-7634(97)00038-9
   BIRINGEN Z, 1995, CHILD DEV, V66, P499, DOI 10.2307/1131593
   Boliek CA, 1996, J VOICE, V10, P1, DOI 10.1016/S0892-1997(96)80015-4
   Buder E. H., 2013, COMPREHENSIVE PERSPE, P103
   Buracchio T, 2010, ARCH NEUROL-CHICAGO, V67, P980, DOI 10.1001/archneurol.2010.159
   Carello C., 2005, CONT METHODS BEHAV S, P1
   CoboLewis AB, 1996, AM J MENT RETARD, V100, P456
   Delignieres D, 2009, J APPL PHYSIOL, V106, P1272, DOI 10.1152/japplphysiol.90757.2008
   DiDonato MD, 2013, HUM DEV, V56, P59, DOI 10.1159/000342936
   EILERS RE, 1993, INFANT BEHAV DEV, V16, P297, DOI 10.1016/0163-6383(93)80037-9
   Ejiri K, 2001, DEVELOPMENTAL SCI, V4, P40, DOI 10.1111/1467-7687.00147
   ELBERS L, 1982, COGNITION, V12, P45, DOI 10.1016/0010-0277(82)90029-4
   Ford M., 2008, LENA LANGUAGE ENV AN
   Frank M. C., 2013, P 35 ANN M COGN SCI, P454
   Franklin B. S., 2014, LANG LEARN DEV, V10, P279, DOI [doi.org/10.1080/15475441.2013.849176, DOI 10.1080/15475441.2013.849176]
   Gibson E. J., 2000, ECOLOGICAL APPROACH
   Goldfield E. C., 1995, EMERGENT FORMS ORIGI
   HAKEN H, 1985, BIOL CYBERN, V51, P347, DOI 10.1007/BF00336922
   Harbourne RT, 2003, DEV PSYCHOBIOL, V42, P368, DOI 10.1002/dev.10110
   Iverson J. M., 1999, J CONSCIOUSNESS STUD, V6, P11
   Iverson J. M., 2008, FIRST LANG, V28, P164, DOI DOI 10.1177/0142723707087736
   Iverson JM, 2010, J CHILD LANG, V37, P229, DOI 10.1017/S0305000909990432
   Iverson JM, 2005, PSYCHOL SCI, V16, P367, DOI 10.1111/j.0956-7976.2005.01542.x
   Iverson JM, 2004, CHILD DEV, V75, P1053, DOI 10.1111/j.1467-8624.2004.00725.x
   Jaffe J, 2001, MONOGR SOC RES CHILD, V66, P1, DOI 10.1111/1540-5834.00137
   Jakobson R., 1962, SELECTED WRITINGS, V1, P538
   Kanemaru N, 2012, EXP BRAIN RES, V218, P49, DOI 10.1007/s00221-012-3001-3
   Kass-Hout TA, 2012, J AM MED INFORM ASSN, V19, P1075, DOI 10.1136/amiajnl-2011-000793
   Kello CT, 2008, COGNITIVE SCI, V32, P1217, DOI 10.1080/03640210801944898
   Kello CT, 2013, PSYCHOL REV, V120, P230, DOI 10.1037/a0030970
   Kelso J. A. S., 1995, DYNAMIC PATTERNS SEL
   Kelso J.A.S., 1984, HDB COGNITIVE NEUROS, P321
   KELSO JAS, 1986, J PHONETICS, V14, P29
   KELSO JAS, 1984, J EXP PSYCHOL HUMAN, V10, P812, DOI 10.1037/0096-1523.10.6.812
   Kimura D., 1973, NEUROPSYCHOLOGIA, V11, P34
   Koterba EA, 2014, AUTISM, V18, P97, DOI 10.1177/1362361312464826
   Kretch KS, 2014, CHILD DEV, V85, P1503, DOI 10.1111/cdev.12206
   Kugler P. N., 1987, INFORM NATURAL LAW S
   Kugler PN, 1980, ADV PSYCHOL, V1, P3, DOI DOI 10.1016/S0166-4115(08)61936-6
   Kuznetsov Nikita A, 2011, Front Integr Neurosci, V5, P62, DOI 10.3389/fnint.2011.00062
   LENNEBER.EH, 1969, SCIENCE, V164, P635, DOI 10.1126/science.164.3880.635
   Lewkowicz DJ, 2000, PSYCHOL BULL, V126, P281
   Locke J., 1989, 1ST LANGUAGE, V9, P191, DOI 10.1177/014272378900900606
   Lowen S. B., 2005, FRACTAL BASED POINT, DOI [10.1002/0471754722, DOI 10.1002/0471754722]
   LOWEN SB, 1992, J ACOUST SOC AM, V92, P803, DOI 10.1121/1.403950
   LYNCH MP, 1995, DEV PSYCHOBIOL, V28, P3, DOI 10.1002/dev.420280103
   McGraw M. B., 1945, NEUROMUSCULAR MATURA
   McNeill D., 1992, HAND MIND WHAT GESTU
   McNeill D., 2000, LANGUAGE GESTURE, V2
   Mowrer OH, 1952, J SPEECH HEAR DISORD, V17, P263
   Nickel LR, 2013, INFANCY, V18, P639, DOI 10.1111/infa.12025
   Oller D., 1980, CHILD PHONOLOGY, P93
   Oller D. K., 2000, EMERGENCE SPEECH CAP
   OLLER DK, 1994, J CHILD LANG, V21, P33
   OLLER DK, 1988, CHILD DEV, V59, P441, DOI 10.1111/j.1467-8624.1988.tb01479.x
   Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107
   Oller DK, 2013, P NATL ACAD SCI USA, V110, P6318, DOI 10.1073/pnas.1300337110
   Oller DK, 2001, DEVELOPMENTAL SCI, V4, P49, DOI 10.1111/1467-7687.00148
   Oller DK, 1997, J CHILD LANG, V24, P407
   Parlade MV, 2011, DEV PSYCHOL, V47, P820, DOI 10.1037/a0021811
   Patten E, 2014, J AUTISM DEV DISORD, V44, P2413, DOI 10.1007/s10803-014-2047-4
   Piek JP, 1999, HUM MOVEMENT SCI, V18, P377, DOI 10.1016/S0167-9457(99)00019-6
   Piek JP, 2002, HUM MOVEMENT SCI, V21, P621, DOI 10.1016/S0167-9457(02)00172-0
   Ramsdell HL, 2012, J SPEECH LANG HEAR R, V55, P1626, DOI 10.1044/1092-4388(2012/11-0250)
   Reed E. S., 1996, ENCOUNTERING WORLD E
   REED ES, 1982, J MOTOR BEHAV, V14, P98
   SALTZMAN E, 1987, PSYCHOL REV, V94, P84, DOI 10.1037//0033-295X.94.1.84
   Saltzman E. L., 1989, ECOL PSYCHOL, V1, P333, DOI 10.1207/s15326969eco0104_2
   Santos-Lozano A, 2012, INT J SPORTS MED, V33, P994, DOI 10.1055/s-0032-1312580
   SCHMIDT RA, 1975, PSYCHOL REV, V82, P225, DOI 10.1037/h0076770
   Shirley M. M., 1931, 1 2 YEARS STUDY 25 B, V1
   Smith L. B., 1993, DYNAMIC SYSTEMS APPR
   Smith LB, 2003, TRENDS COGN SCI, V7, P343, DOI 10.1016/S1364-6613(03)00156-6
   Smith SL, 2010, J LEARN DISABIL-US, V43, P294, DOI 10.1177/0022219410369094
   Soderstrom M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080646
   Spencer JP, 2000, DEVELOPMENTAL SCI, V3, P216, DOI 10.1111/1467-7687.00115
   Stark RE, 1980, CHILD PHONOLOGY, P73
   Stephen DG, 2012, CHAOS SOLITON FRACT, V45, P1201, DOI 10.1016/j.chaos.2012.06.005
   Stephen DG, 2009, J EXP PSYCHOL HUMAN, V35, P1811, DOI 10.1037/a0014510
   Stergiou N., 2013, KINESIOL REV, V2, P93
   Takens F., 1981, LECT NOTES MATH, V898, P366, DOI DOI 10.1007/BFB0091924
   THELEN E, 1995, AM PSYCHOL, V50, P79, DOI 10.1037//0003-066X.50.2.79
   THELEN E, 1993, CHILD DEV, V64, P1058, DOI 10.1111/j.1467-8624.1993.tb04188.x
   THELEN E, 1983, CHILD DEV, V54, P129, DOI 10.1111/j.1467-8624.1983.tb00341.x
   THELEN E, 1987, DEV REV, V7, P39, DOI 10.1016/0273-2297(87)90004-9
   THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X
   Turvey M. T., 1992, Ecological Psychology, V4, P173, DOI 10.1207/s15326969eco0403_3
   Van Orden GC, 2005, J EXP PSYCHOL GEN, V134, P117, DOI 10.1037/0096-3445.134.1.117
   Van Orden GC, 2003, J EXP PSYCHOL GEN, V132, P331, DOI 10.1037/0096-3445.132.3.331
   Vereijken B, 1997, DEV PSYCHOBIOL, V30, P89, DOI 10.1002/(SICI)1098-2302(199703)30:2<89::AID-DEV1>3.0.CO;2-Q
   Vereijken B, 2010, PHYS THER, V90, P1850, DOI 10.2522/ptj.20100019
   Vereijken B, 1999, NON-LINEAR DEVELOPMENTAL PROCESSES, P137
   Vihman M. M., 1996, PHONOLOGICAL DEV ORI
   VIHMAN MM, 1985, LANGUAGE, V61, P397, DOI 10.2307/414151
   Walle EA, 2014, DEV PSYCHOL, V50, P336, DOI 10.1037/a0033238
   Warlaumont AS, 2014, PSYCHOL SCI, V25, P1314, DOI 10.1177/0956797614531023
   Watanabe H, 2009, INFANT BEHAV DEV, V32, P79, DOI 10.1016/j.infbeh.2008.10.003
   Webber Jr CL, 2005, TUTORIALS CONT NONLI, P26
   Weisleder A, 2013, PSYCHOL SCI, V24, P2143, DOI 10.1177/0956797613488145
   Xu D., 2009, RELIABILITY LENA LAN
   Xu D., 2008, LENATM LANGUAGE ENV
   Yale ME, 2003, DEV PSYCHOL, V39, P815, DOI 10.1037/0012-1649.39.5.815
   Yingling J., 1981, THESIS U DENVER
   Zbilut JP, 1998, PHYS LETT A, V246, P122, DOI 10.1016/S0375-9601(98)00457-5
NR 113
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD AUG 12
PY 2014
VL 5
AR 771
DI 10.3389/fpsyg.2014.00771
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA AO5EP
UT WOS:000341366500001
PM 25161629
ER

PT J
AU Kasirer, A
   Mashal, N
AF Kasirer, Anat
   Mashal, Nira
TI Verbal creativity in autism: comprehension and generation of metaphoric
   language in high-functioning autism spectrum disorder and typical
   development
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism; novel metaphors; executive functioning; metaphor generation
ID VEGETATIVE STATE; AUTOBIOGRAPHICAL MEMORY; CONSCIOUSNESS; HABITUATION;
   COGNITION; STIMULI; BRAIN; ATTENTION; AWARENESS; EMOTION
AB Studies on creativity in participants with autism generally show impoverished performance as well as deficient comprehension of metaphoric language. However, very little is known about the ability to generate metaphors in this population. The present study examines verbal creativity in adults with autism-spectrum disorder (ASD) through tasks that rely on novel metaphoric language. Seventeen adults with ASD (mean age = 21.06) and 17 typically developing peers (mean age = 22.71) participated in the study. A multiple-choice questionnaire consisting of conventional and novel metaphors was used to test comprehension, and a sentence completion questionnaire was used to test generation of creative language. Results show similar performance in comprehension of conventional and novel metaphors in both groups, whereas adults with ASD generated more creative metaphors relative to the control group. Scores on tests of vocabulary and naming contributed to the prediction of conventional metaphor comprehension, while scores on tests of mental flexibility contributed to the prediction of novel metaphor comprehension. In addition, scores on a test of non-verbal intelligence contributed to the prediction of metaphor generation. The study points to unique verbal creativity in ASD.
C1 [Kasirer, Anat; Mashal, Nira] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
   [Mashal, Nira] Bar Ilan Univ, Gonda Multidisciplinary Brain Res Ctr, IL-52900 Ramat Gan, Israel.
RP Mashal, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM nmashal2@gmail.com
RI Ma, Min/F-6963-2010
CR Abbate C., 2011, RIABILITAZIONE NEURO, P389
   Bekinschtein TA, 2008, J NEUROL NEUROSUR PS, V79, P826, DOI 10.1136/jnnp.2007.132738
   Cabeza R, 2007, TRENDS COGN SCI, V11, P219, DOI 10.1016/j.tics.2007.02.005
   Casali AG, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3006294
   Coleman MR, 2007, BRAIN, V130, P2494, DOI 10.1093/brain/awm170
   Cruse D, 2012, NEUROLOGY, V78, P816, DOI 10.1212/WNL.0b013e318249f764
   Dehaene S, 2006, TRENDS COGN SCI, V10, P204, DOI 10.1016/j.tics.2006.03.007
   Dehaene S, 2011, NEURON, V70, P200, DOI 10.1016/j.neuron.2011.03.018
   Di H., 2012, COMA DISORDERS CONSC, P97, DOI [10.1007/978-1-4471-2440-5_10, DOI 10.1007/978-1-4471-2440-5_10]
   Di Stefano C, 2012, BRAIN INJURY, V26, P1250, DOI 10.3109/02699052.2012.667588
   Ghazanfar AA, 2006, TRENDS COGN SCI, V10, P278, DOI 10.1016/j.tics.2006.04.008
   Giacino JT, 1996, NEUROREHABILITATION, V6, P69, DOI 10.3233/NRE-1996-6108
   Hasson U., 2009, TRENDS COGN SCI, V14, P40, DOI 10.1016/j.tics.2009.10.011
   Hommel B, 2009, OXFORD HDB HUMAN ACT, P371
   Hugo J. S., 2007, TRENDS COGN SCI, V11, P356, DOI [10.1016/j.tics.2007.06.002, DOI 10.1016/J.TICS.2007.06.002]
   Kolb B., 2008, COGNITIVE NEUROREHAB, P16
   Lancioni G, 2011, DEV NEUROREHABIL, V14, P358, DOI 10.3109/17518423.2011.605076
   Lancioni GE, 2008, EUR J PHYS REHAB MED, V44, P449
   Lancioni GE, 2014, FRONT HUM NEUROSCI, V8, DOI 10.3389/fnhum.2014.00048
   Lancioni GE, 2010, RES DEV DISABIL, V31, P1121, DOI 10.1016/j.ridd.2010.06.019
   Lang PJ, 2010, BIOL PSYCHOL, V84, P437, DOI 10.1016/j.biopsycho.2009.10.007
   Laureys S, 2005, TRENDS COGN SCI, V9, P556, DOI 10.1016/j.tics.2005.10.010
   Lombardi F, 2002, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001427
   Markowitsch HJ, 2011, CONSCIOUS COGN, V20, P16, DOI 10.1016/j.concog.2010.09.005
   Monti MM, 2010, NEW ENGL J MED, V362, P579, DOI 10.1056/NEJMoa0905370
   Owen AM, 2006, SCIENCE, V313, P1402, DOI 10.1126/science.1130197
   Owen M. A., 2008, NAT REV NEUROSCI, V9, P235, DOI [10.1038/nrn2330, DOI 10.1038/NRN2330]
   Pessoa L, 2005, CURR OPIN NEUROBIOL, V15, P188, DOI 10.1016/j.conb.2005.03.002
   Pessoa L, 2008, NAT REV NEUROSCI, V9, P148, DOI 10.1038/nrn2317
   Pessoa L, 2009, TRENDS COGN SCI, V13, P160, DOI 10.1016/j.tics.2009.01.006
   Phelps EA, 2006, ANNU REV PSYCHOL, V57, P27, DOI 10.1146/annurev.psych.56.091103.070234
   Piolino P, 2009, NEUROPSYCHOLOGIA, V47, P2314, DOI 10.1016/j.neuropsychologia.2009.01.020
   Ponce FP, 2011, BIOL RES, V44, P295, DOI [/S0716-97602011000300011, 10.4067/S0716-97602011000300011]
   Rankin CH, 2009, NEUROBIOL LEARN MEM, V92, P135, DOI 10.1016/j.nlm.2008.09.012
   RITTER W, 1968, ELECTROEN CLIN NEURO, V25, P550, DOI 10.1016/0013-4694(68)90234-4
   Rosanova M, 2012, BRAIN, V135, P1308, DOI 10.1093/brain/awr340
   Schiff N. D., 2005, NEUROLOGY, V64, P524, DOI [10.1212/01.WNL.0000150883.10285.44, DOI 10.1212/01.WNL.0000.150883.10285.44]
   Schiff ND, 2002, BRAIN, V125, P1210, DOI 10.1093/brain/awf131
   Schwartz MF, 2002, NEUROPSYCHOL REHABIL, V12, P311, DOI 10.1080/09602010244000084
   Svoboda E, 2006, NEUROPSYCHOLOGIA, V44, P2189, DOI 10.1016/j.neuropsychologia.2006.05.023
   Talsma D, 2010, TRENDS COGN SCI, V14, P400, DOI 10.1016/j.tics.2010.06.008
   Thompson RF, 2009, NEUROBIOL LEARN MEM, V92, P127, DOI 10.1016/j.nlm.2008.07.011
   Tononi Giulio, 2004, BMC Neurosci, V5, P42, DOI 10.1186/1471-2202-5-42
   Tulving E, 2002, ANNU REV PSYCHOL, V53, P1, DOI 10.1146/annurev.psych.53.100901.135114
   Vuilleumier P, 2005, TRENDS COGN SCI, V9, P585, DOI 10.1016/j.tics.2005.10.011
NR 45
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD AUG 11
PY 2014
VL 8
AR 615
DI 10.3389/fnhum.2014.00615
PG 13
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AN6MR
UT WOS:000340709100001
PM 25157225
ER

PT J
AU Xuan, ICY
   Hampson, DR
AF Xuan, Ingrid C. Y.
   Hampson, David R.
TI Gender-Dependent Effects of Maternal Immune Activation on the Behavior
   of Mouse Offspring
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; SEX-DIFFERENCES; ANIMAL-MODELS; INFECTION;
   SCHIZOPHRENIA; CHILDREN; RECEPTOR; BRAIN; MICE; AGE
AB Autism spectrum disorders are neurodevelopmental disorders characterized by two core symptoms; impaired social interactions and communication, and ritualistic or repetitive behaviors. Both epidemiological and biochemical evidence suggests that a subpopulation of autistics may be linked to immune perturbations that occurred during fetal development. These findings have given rise to an animal model, called the "maternal immune activation'' model, whereby the offspring from female rodents who were subjected to an immune stimulus during early or mid-pregnancy are studied. Here, C57BL/6 mouse dams were treated mid-gestation with saline, lipopolysaccharide (LPS) to mimic a bacterial infection, or polyinosinic: polycytidylic acid (Poly IC) to mimic a viral infection. Autism-associated behaviors were examined in the adult offspring of the treated dams. Behavioral tests were conducted to assess motor activity, exploration in a novel environment, sociability, and repetitive behaviors, and data analyses were carried independently on male and female mice. We observed a main treatment effect whereby male offspring from Poly IC-treated dams showed reduced motor activity. In the marble burying test of repetitive behavior, male offspring but not female offspring from both LPS and Poly IC-treated mothers showed increased marble burying. Our findings indicate that offspring from mothers subjected to immune stimulation during gestation show a gender-specific increase in stereotyped repetitive behavior.
C1 [Xuan, Ingrid C. Y.; Hampson, David R.] Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON, Canada.
   [Hampson, David R.] Univ Toronto, Dept Pharmacol & Toxicol, Fac Med, Toronto, ON, Canada.
RP Hampson, DR (reprint author), Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON, Canada.
EM d.hampson@utoronto.ca
FU Canadian Institutes for Health Research (CIHR); CIHR Strategic Training
   Program in Biological Therapeutics
FX This work was supported by the Canadian Institutes for Health Research
   (CIHR) and the CIHR Strategic Training Program in Biological
   Therapeutics. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Alexopoulou L, 2001, NATURE, V413, P732, DOI 10.1038/35099560
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Andersson GW, 2013, RES DEV DISABIL, V34, P413, DOI 10.1016/j.ridd.2012.08.025
   Ashdown H, 2006, MOL PSYCHIATR, V11, P47, DOI 10.1038/sj.mp.4001748
   Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Bakos J, 2004, ANN NY ACAD SCI, V1018, P281, DOI 10.1196/annals.1293.033
   Brown AS, 2013, MOL PSYCHIA IN PRESS
   Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
   Carpenter S, 2013, SCIENCE, V341, P789, DOI 10.1126/science.1240925
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Ehninger D, 2012, MOL PSYCHIATR, V17, P62, DOI 10.1038/mp.2010.115
   Garay PA, 2013, BRAIN BEHAV IMMUN, V31, P54, DOI 10.1016/j.bbi.2012.07.008
   Gillberg C, 2006, J AUTISM DEV DISORD, V36, P429, DOI 10.1007/s10803-006-0081-6
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harvey L, 2012, DEV NEUROBIOL, V72, P1335, DOI 10.1002/dneu.22043
   Hattier MA, 2011, RES DEV DISABIL, V32, P2346, DOI 10.1016/j.ridd.2011.07.028
   Hsiao EY, 2012, P NATL ACAD SCI USA, V109, P12776, DOI 10.1073/pnas.1202556109
   Jones KA, 2013, MOL CELL NEUROSCI, V53, P52, DOI 10.1016/j.mcn.2012.10.002
   Kalueff AV, 2005, J NEUROSCI METH, V143, P169, DOI 10.1016/j.jneumeth.2004.10.001
   Kim KC, 2013, J NEUROCHEM, V124, P832, DOI 10.1111/jnc.12147
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kirsten TB, 2010, BEHAV BRAIN RES, V211, P77, DOI 10.1016/j.bbr.2010.03.009
   Kirsten TB, 2012, J NEUROSCI RES, V90, P1903, DOI 10.1002/jnr.23089
   Lipina TV, 2013, J NEUROSCI, V33, P7654, DOI 10.1523/JNEUROSCI.0091-13.2013
   Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
   Mandy W, 2012, J AUTISM DEV DISORD, V42, P1304, DOI 10.1007/s10803-011-1356-0
   Maski KP, 2011, CURR OPIN PEDIATR, V23, P609, DOI 10.1097/MOP.0b013e32834c9282
   Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Netea MG, 2002, TRENDS IMMUNOL, V23, P135, DOI 10.1016/S1471-4906(01)02169-X
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Pacey LKK, 2011, MOL CELL NEUROSCI, V46, P563, DOI 10.1016/j.mcn.2010.12.005
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
   Piontkewitz Y, 2009, BIOL PSYCHIAT, V66, P1038, DOI 10.1016/j.biopsych.2009.07.005
   Ramsey AJ, 2011, P NATL ACAD SCI USA, V108, P5795, DOI 10.1073/pnas.1012621108
   Rana SA, 2012, HORM BEHAV, V62, P228, DOI 10.1016/j.yhbeh.2012.03.015
   Schwartzer JJ, 2013, TRANSL PSYCHIAT, V3
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Sipes M, 2011, RES AUTISM SPECT DIS, V5, P1465, DOI 10.1016/j.rasd.2011.02.007
   Suzuki S, 2013, J NEUROSCI RES, V91, P462, DOI 10.1002/jnr.23160
   Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   Worley JA, 2011, RES AUTISM SPECT DIS, V5, P1086, DOI 10.1016/j.rasd.2010.12.002
   Zager A, 2012, BEHAV BRAIN RES, V232, P30, DOI 10.1016/j.bbr.2012.03.036
   Zahn-Waxler C, 2008, ANNU REV CLIN PSYCHO, V4, P275, DOI [10.1146/annurev.clinpsy.3.022806.091358, 10.1146/annurev.clinpsy.3.022806.0913]
   Zwaigenbaum L, 2012, J AUTISM DEV DISORD, V42, P2585, DOI 10.1007/s10803-012-1515-y
NR 52
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 11
PY 2014
VL 9
IS 8
AR e104433
DI 10.1371/journal.pone.0104433
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO1WB
UT WOS:000341105100057
PM 25111339
ER

PT J
AU Gonzalez-Valenzuela, MJ
   Garcia-Fortea, P
   Delgado-Rios, M
   Cazorla-Granados, O
   Blasco-Alonso, M
   Gonzalez-Mesa, E
AF Jose Gonzalez-Valenzuela, Maria
   Garcia-Fortea, Pedro
   Delgado-Rios, Myriam
   Cazorla-Granados, Olga
   Blasco-alonso, Marta
   Gonzalez-Mesa, Ernesto
TI Effects of oxytocin used during delivery on development: A retrospective
   cohort study
SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
LA English
DT Article
DE Uterine stimulants; Retrospective cohort study; Psychological
   development disability; Synthetic oxytocin; Battelle Inventory
ID LOGISTIC-REGRESSION ANALYSIS; AUTISM SPECTRUM DISORDERS;
   PITUITARY-ADRENAL AXIS; SOCIAL BEHAVIORS; VASOPRESSIN; LABOR; RECEPTOR;
   BRAIN; RISK; INDUCTION
AB Objective: The objective was to evaluate the potential influence of oxytocin administered during delivery on children's development at the age of 5. Method: This study was designed as a retrospective cohort study where children from patients given synthetic oxytocin during delivery were considered as the exposed cohort and children from patients not given oxytocin as the nonexposed cohort. From a total of 7465 births attended at our maternity ward in 2006, an initial sample of 400 was randomly selected. A total of 148 children were evaluated using the Battelle Developmental Inventory. Potential confounding and adjustment factors were analyzed using stratified analysis and multivariate analysis (logistic regression). Results: Oxytocin use did not significantly affect the overall risk of developmental delay in the study sample (relative risk, RR, 1.46; 95% confidence interval, CI [0.79-2.71]). The best fit regression model included twin delivery, type of delivery, and maternal age. In the group of vaginal noninstrumental deliveries, oxytocin administration increased the risk of poor Battelle Developmental Inventory outcome, particularly when maternal age was under 28 or over 35 years of age (odds ratio, OR, 67.14; 95% CI [5.46-824.86]). When delivery was instrumental or through cesarean section in mothers aged 28-35 years, oxytocin administration decreased the risk of developmental disorders (OR 0.16; 95% CI [0.04-0.66]). Conclusion: Although oxytocin administration during delivery did not affect the overall risk of low Battelle Developmental Inventory scores in the study sample, some effects were seen according to maternal age and type of birth.
C1 [Jose Gonzalez-Valenzuela, Maria; Delgado-Rios, Myriam; Cazorla-Granados, Olga] Univ Malaga, Fac Psychol, Dept Dev & Educ Psychol, Malaga 29011, Spain.
   [Garcia-Fortea, Pedro; Blasco-alonso, Marta; Gonzalez-Mesa, Ernesto] Univ Malaga, Malaga Obstet & Gynecol Res Grp, IBIMA, Malaga 29011, Spain.
RP Gonzalez-Mesa, E (reprint author), Univ Malaga, Obstet & Gynecol Res Grp, IBIMA, Arroyo Angeles S-N, Malaga 29011, Spain.
EM egonzalezmesa@gmail.com
CR ACOG Committee on Practice Bulletins-Obstetrics, 2009, J OBSTET GYNECOLOGY, V114, P386
   ANAGNOSTAKIS D, 1992, J PEDIATR-US, V121, P291, DOI 10.1016/S0022-3476(05)81207-7
   Belfer ML, 2008, J CHILD PSYCHOL PSYC, V49, P226, DOI 10.1111/j.1469-7610.2007.01855.x
   Blom EA, 2010, BJOG-INT J OBSTET GY, V117, P1390, DOI 10.1111/j.1471-0528.2010.02660.x
   Borrow AP, 2012, HORM BEHAV, V61, P266, DOI 10.1016/j.yhbeh.2011.11.001
   Caldwell HK, 2008, PROG NEUROBIOL, V84, P1, DOI 10.1016/j.pneurobio.2007.10.007
   Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025
   Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
   Cruz De la, 2009, INVENTARIO DESARROLL
   Curley JP, 2012, HORM BEHAV, V61, P454, DOI 10.1016/j.yhbeh.2012.01.013
   Dahlen HG, 2013, MED HYPOTHESES, V80, P656, DOI 10.1016/j.mehy.2013.01.017
   De Dreu CKW, 2012, HORM BEHAV, V61, P419, DOI 10.1016/j.yhbeh.2011.12.009
   DEGEEST K, 1985, J PERINAT MED, V13, P3, DOI 10.1515/jpme.1985.13.1.3
   DU VIGNEAUD V, 1955, Experientia, P9
   DUVIGNEAUD V, 1953, J BIOL CHEM, V205, P949
   Ebstein RP, 2012, HORM BEHAV, V61, P359, DOI 10.1016/j.yhbeh.2011.12.014
   Ebstein RP, 2009, ANN NY ACAD SCI, V1167, P87, DOI 10.1111/j.1749-6632.2009.04541.x
   Evers ACC, 2013, ACTA OBSTET GYN SCAN, V92, P85, DOI 10.1111/aogs.12012
   Fan AP, 2014, COMPR PSYCHIAT, V55, P283, DOI 10.1016/j.comppsych.2013.08.024
   Fernandez IO, 2012, ACTA PAEDIATR, V101, P749, DOI 10.1111/j.1651-2227.2012.02668.x
   Garcia-Fortea P, 2014, J MATERN-FETAL NEO M, V27, P1598, DOI 10.3109/14767058.2013.871255
   Gimpl G, 2001, PHYSIOL REV, V81, P629
   Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
   Grace CE, 2011, BIRTH DEFECTS RES A, V91, P797, DOI 10.1002/bdra.20824
   Greenland S., 2000, BIOSTATISTICS, V1, P113, DOI 10.1093/biostatistics/1.1.113
   Greenland S, 2000, AM J EPIDEMIOL, V151, P531
   Gressens P, 2001, Semin Neonatol, V6, P185, DOI 10.1053/siny.2001.0048
   Guastella Adam J, 2012, Horm Behav, V61, P410, DOI 10.1016/j.yhbeh.2012.01.002
   Guerra GV, 2011, B WORLD HEALTH ORGAN, V89, P657, DOI 10.2471/BLT.08.061226
   Higashida H, 2012, HORM BEHAV, V61, P351, DOI 10.1016/j.yhbeh.2011.12.011
   Instituto Nacional de Estadistica, 2013, NAC PROV INSCR MAL T
   Jonas K, 2009, Breastfeed Med, V4, P71, DOI 10.1089/bfm.2008.0002
   Kendrick KM, 2000, EXP PHYSIOL, V85, p111S, DOI 10.1111/j.1469-445X.2000.tb00014.x
   Khazipov R, 2008, PROG BRAIN RES, V170, P243, DOI 10.1016/S0079-6123(08)00421-4
   Kurth L, 2011, J ATTEN DISORD, V15, P423, DOI 10.1177/1087054710397800
   López Gómez Santiago, 2008, Psicothema, V20, P684
   Malek A, 1996, J Matern Fetal Med, V5, P245, DOI 10.3109/14767059609025430
   Moraleda-Barreno E, 2011, AN PEDIATR, V75, P372, DOI 10.1016/j.anpedi.2011.06.004
   Neumann ID, 2008, J NEUROENDOCRINOL, V20, P858, DOI 10.1111/j.1365-2826.2008.01726.x
   Odent MR, 2013, MED HYPOTHESES, V81, P889, DOI 10.1016/j.mehy.2013.07.044
   Patka JH, 2005, ANN PHARMACOTHER, V39, P95, DOI 10.1345/aph.1E037
   Peduzzi P, 1996, J CLIN EPIDEMIOL, V49, P1373, DOI 10.1016/S0895-4356(96)00236-3
   Petersen A, 2013, ARCH GYNECOL OBSTET, V288, P245, DOI 10.1007/s00404-013-2737-8
   Phaneuf S, 1998, HUM REPROD UPDATE, V4, P625, DOI 10.1093/humupd/4.5.625
   Phaneuf S, 2000, J REPROD FERTIL, V120, P91, DOI 10.1530/reprod/120.1.91
   Pobbe RLH, 2012, PHYSIOL BEHAV, V107, P641, DOI 10.1016/j.physbeh.2012.02.024
   Robinson C, 2003, AM J OBSTET GYNECOL, V188, P497, DOI 10.1067/mob.2003.22
   Rothman K, 2008, EPISHEET EXCEL SPREA
   Saunders NR, 1999, CLIN EXP PHARMACOL P, V26, P85, DOI 10.1046/j.1440-1681.1999.02987.x
   SELLERS SM, 1981, BRIT J OBSTET GYNAEC, V88, P725, DOI 10.1111/j.1471-0528.1981.tb01273.x
   Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
   SHYKEN JM, 1995, CLIN OBSTET GYNECOL, V38, P232, DOI 10.1097/00003081-199506000-00006
   Strathearn L, 2012, HORM BEHAV, V61, P429, DOI 10.1016/j.yhbeh.2012.01.014
   Tam T, 2013, ARCH GYNECOL OBSTET, V287, P407, DOI 10.1007/s00404-012-2582-1
   TSAI LY, 1983, J AUTISM DEV DISORD, V13, P57, DOI 10.1007/BF01531359
   TURNBULL ALEXANDER C, 1968, J OBSTET GYNAECOL BRIT COMMONW, V75, P24
   Veenema AH, 2012, HORM BEHAV, V61, P304, DOI 10.1016/j.yhbeh.2011.12.002
   World Health Organization, 2011, WHO REC IND LAB
   Xiong FX, 2013, FRONT NEUROENDOCRIN, V34, P27, DOI 10.1016/j.yfrne.2012.11.002
   Zhang J, 2011, OBSTET GYNECOL, V118, P249, DOI 10.1097/AOG.0b013e3182220192
   Zingg HH, 2003, TRENDS ENDOCRIN MET, V14, P222, DOI 10.1016/S1043-2760(03)00080-8
   Zink CF, 2012, HORM BEHAV, V61, P400, DOI 10.1016/j.yhbeh.2012.01.016
NR 62
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1380-3395
EI 1744-411X
J9 J CLIN EXP NEUROPSYC
JI J. Clin. Exp. Neuropsychol.
PD AUG 9
PY 2014
VL 36
IS 7
BP 680
EP 690
DI 10.1080/13803395.2014.926864
PG 11
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA AR0XK
UT WOS:000343298000002
PM 24915966
ER

PT J
AU Fantasia, V
   De Jaegher, H
   Fasulo, A
AF Fantasia, Valentina
   De Jaegher, Hanne
   Fasulo, Alessandra
TI We can work it out: an enactive look at cooperation
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE cooperation; development; autism; infancy; social interaction;
   participatory sense-making
ID JOINT ACTION; AUTISM; INTENTIONS; CHILDREN; COMMUNICATION; ATTENTION;
   COGNITION; LANGUAGE; OTHERS; INTERSUBJECTIVITY
AB The past years have seen an increasing debate on cooperation and its unique human character. Philosophers and psychologists have proposed that cooperative activities are characterized by shared goals to which participants are committed through the ability to understand each other's intentions. Despite its popularity, some serious issues arise with this approach to cooperation. First, one may challenge the assumption that high-level mental processes are necessary for engaging in acting cooperatively. If they are, then how do agents that do not possess such ability (preverbal children, or children with autism who are often claimed to be mind-blind) engage in cooperative exchanges, as the evidence suggests? Secondly, to define cooperation as the result of two de-contextualized minds reading each other's intentions may fail to fully acknowledge the complexity of situated, interactional dynamics and the interplay of variables such as the participants' relational and personal history and experience. In this paper we challenge such accounts of cooperation, calling for an embodied approach that sees cooperation not only as an individual attitude toward the other, but also as a property of interaction processes. Taking an enactive perspective, we argue that cooperation is an intrinsic part of any interaction, and that there can be cooperative interaction before complex communicative abilities are achieved. The issue then is not whether one is able or not to read the other's intentions, but what it takes to participate in joint action. From this basic account, it should be possible to build up more complex forms of cooperation as needed. Addressing the study of cooperation in these terms may enhance our understanding of human social development, and foster our knowledge of different ways of engaging with others, as in the case of autism.
C1 [Fantasia, Valentina; Fasulo, Alessandra] Univ Portsmouth, Ctr Situated Act & Commun, Dept Psychol, Portsmouth PO1 2DY, Hants, England.
   [De Jaegher, Hanne] Univ Basque Country, IAS Res Ctr Life Mind & Soc, Dept Log & Philosophy Sci, San Sebastian 20018, Spain.
   [De Jaegher, Hanne] Univ Sussex, Ctr Computat Neurosci & Robot, Brighton, E Sussex, England.
RP Fantasia, V (reprint author), Univ Portsmouth, Ctr Situated Act & Commun, Dept Psychol, King Henry 1 St, Portsmouth PO1 2DY, Hants, England.
EM valentina.fantasia@port.ac.uk; h.de.jaegher@gmail.com
CR Aldridge MA, 2000, DEVELOPMENTAL SCI, V3, P294, DOI 10.1111/1467-7687.00123
   Apperly I, 2011, MINDREADERS: THE COGNITIVE BASIS OF THEORY OF MIND, P1
   Baron- Cohen S., 1989, DEV PSYCHOPATHOL, V1, P185, DOI 10.1017/ S0954579400000377
   Bjorne P., 2007, LUND U COGN STUD, V134, P210
   Boucher J, 2012, AUTISM, V16, P603, DOI 10.1177/1362361311417738
   Boucher J., 1989, INT J LANG COMM DIS, V24, P181, DOI [10.3109/13682828909011955, DOI 10.3109/13682828909011955]
   Boucher J., 1996, THEORIES THEORIES MI, P223
   Braten S, 2003, CULT PSYCHOL, V9, P261, DOI 10.1177/1354067X030093007
   BRATMAN ME, 1993, ETHICS, V104, P97, DOI 10.1086/293577
   BRATMAN ME, 1992, PHILOS REV, V101, P327, DOI 10.2307/2185537
   Brownell A. C., 2006, CHILD DEV, V77, P803, DOI [10. 1086/ 293577, DOI 10.1086/293577]
   BROWNELL CA, 1990, CHILD DEV, V61, P1164, DOI 10.1111/j.1467-8624.1990.tb02850.x
   Bruner J., 1977, STUDIES MOTHER INFAN
   Butterfill S, 2012, PHILOS QUART, V62, P23, DOI 10.1111/j.1467-9213.2011.00005.x
   Carpenter M, 2001, J AUTISM DEV DISORD, V31, P589, DOI 10.1023/A:1013251112392
   Colombi C, 2009, AUTISM, V13, P143, DOI 10.1177/1362361308098514
   Condon W. S., 1979, BEFORE SPEECH, P131
   CONDON WS, 1974, SCIENCE, V183, P99, DOI 10.1126/science.183.4120.99
   Cui X, 2012, NEUROIMAGE, V59, P2430, DOI 10.1016/j.neuroimage.2011.09.003
   Davis M., 1982, INTERACTION RHYTHMS
   De Jaegher H., 2007, PHENOMENOLOGY COGNIT, V6, P485, DOI [DOI 10.1007/S11097-007-9076-9, 10.1007/s11097-007-9076-9]
   De Jaegher Hanne, 2013, Front Integr Neurosci, V7, P15, DOI 10.3389/fnint.2013.00015
   De Jaegher H, 2009, CONSCIOUS COGN, V18, P535, DOI 10.1016/j.concog.2008.10.007
   De Jaegher H, 2010, TRENDS COGN SCI, V14, P441, DOI 10.1016/j.tics.2010.06.009
   Delafield-Butt JT, 2013, DEV REV, V33, P399, DOI 10.1016/j.dr.2013.09.001
   Di Paolo E, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00163
   Di Paolo E. A., 2005, COGNITIVE SCI, V4, P97, DOI DOI 10.1007/S11097-005-9002-Y
   Di Paolo E. A., 2010, ENACTION NEW PARADIG, P33
   Dickerson P., 2007, GESTURE, V7, P271, DOI 10.1075/gest.7.3.02dic
   Dinishak J, 2013, CHILD DEV PERSPECT, V7, P110, DOI 10.1111/cdep.12026
   Donaldson Margaret, 1978, CHILDRENS MINDS
   Donnellan A. A., 2013, FRONT INTEGR NEUROSC, V6, P124, DOI [DOI 10.3389/FNINT.2012.00124, 10. 3389/fnint. 2012.00124]
   Dumas G, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012166
   Dumas G, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00128
   Fantasia V, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00522
   Forrester MA, 2008, RES LANG SOC INTERAC, V41, P99, DOI 10.1080/08351810701691206
   Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
   Frith CD, 2007, PHILOS T R SOC B, V362, P671, DOI 10.1098/rstb.2006.2003
   Fuchs T, 2009, PHENOMENOL COGN SCI, V8, P465, DOI 10.1007/s11097-009-9136-4
   Gallagher S, 2001, J CONSCIOUSNESS STUD, V8, P83
   Gallese V, 2003, PHILOS T R SOC B, V358, P517, DOI 10.1098/rstb.2002.1234
   Gernsbacher MA, 2008, CHILD DEV PERSPECT, V2, P38, DOI 10.1111/j.1750-8606.2008.00039.x
   Gilbert M., 1989, SOCIAL FACTS
   Gilbert Margaret, 2000, SOCIALITY RESPONSIBI
   GOFFMAN E, 1983, AM SOCIOL REV, V48, P1, DOI 10.2307/2095141
   Goodwin C, 2013, J PRAGMATICS, V46, P8, DOI 10.1016/j.pragma.2012.09.003
   GOODWIN C, 1995, RES LANG SOC INTERAC, V28, P233, DOI 10.1207/s15327973rlsi2803_4
   Grammer K, 1998, J NONVERBAL BEHAV, V22, P3, DOI 10.1023/A:1022986608835
   Happe F., 1994, AUTISM INTRO PSYCHOL
   Holt S, 2014, J AUTISM DEV DISORD, V44, P236, DOI 10.1007/s10803-013-1868-x
   Hubley P., 1979, NEW DIR CHILD ADOLES, V4, P57, DOI 10.1002/cd. 23219790406
   Hubley P., 1983, THESIS U EDINBURGH E
   Issartel J, 2007, NEUROSCI LETT, V411, P174, DOI 10.1016/j.neulet.2006.09.086
   Jaffe J., 2001, RHYTHMSOF DIALOGUE I
   Johnson M., 2007, MEANING BODY AESTHET, DOI [10.7208/chicago/9780226026992.001.0001, DOI 10.7208/CHICAGO/9780226026992.001.0001]
   Jonas H., 1966, PHENOMENON LIFE PHIL
   Kelso J. A. S., 2009, ENCY COMPLEXITY SYST, P1537, DOI DOI 10.1007/978-0-387-30440-3_101
   Kendon A., 1990, CONDUCTING INTERACTI
   Knoblich G, 2008, PHILOS T R SOC B, V363, P2021, DOI 10.1098/rstb.2008.0006
   Konvalinka I, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00215
   Lerner G. H., 2011, EMBODIED INTERACTION, P44
   Leudar I., 2009, THEORY MIND, DOI [10.1057/9780230234383, DOI 10.1057/9780230234383]
   Liebal K, 2008, J AUTISM DEV DISORD, V38, P224, DOI 10.1007/s10803-007-0381-5
   Lindenberger U, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-22
   LOCAL J, 1995, CLIN LINGUIST PHONET, V9, P155, DOI 10.3109/02699209508985330
   LOVELAND KA, 1986, J AUTISM DEV DISORD, V16, P335, DOI 10.1007/BF01531663
   Macmurray J., 1991, PERSONS RELATION
   Malloch S., 2009, COMMUNICATIVE MUSICA
   Malloch S. N., 2000, MUSIC SCI S1, V3, P29
   MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x
   MCGANN M., 2007, PHENOMENOLOGY COGNIT, V6, P463, DOI DOI 10.1007/S11097-007-9074-Y
   McGann M, 2013, REV GEN PSYCHOL, V17, P203, DOI 10.1037/a0032935
   Mehus S., 2011, EMBODIED COGNITION L, P123
   Merleau-Ponty M, 1962, PHENOMENOLOGY PERCEP
   Merritt M, 2015, PHENOMENOL COGN SCI, V14, P95, DOI 10.1007/s11097-013-9314-2
   Moll H, 2007, PHILOS T R SOC B, V362, P639, DOI 10.1098/rstb.2006.2000
   Nomikou I, 2011, IEEE T AUTON MENT DE, V3, P113, DOI 10.1109/TAMD.2011.2140113
   Pacherie E., 2006, DOES CONSCIOUSNESS C, P145
   Penn D. C., 2008, SOCIAL INTELLIGENCE, P415
   PSATHAS G, 1968, SOC RES, V35, P500
   Raczaszek-Leonardi J, 2013, IEEE T AUTON MENT DE, V5, P210, DOI 10.1109/TAMD.2013.2273258
   Reddy V., 2009, THEORY MIND, P91
   Reddy V., 2008, INFANTS KNOW MINDS
   Reddy V, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065289
   Robledo Jodi, 2012, Front Integr Neurosci, V6, P107, DOI 10.3389/fnint.2012.00107
   Sacks H., 1992, LECT CONVERSATION
   SACKS H, 1974, LANGUAGE, V50, P696, DOI 10.2307/412243
   Sally D, 2006, J ECON PSYCHOL, V27, P73, DOI 10.1016/j.joep.2005.06.015
   Schegloff EA, 2007, J PRAGMATICS, V39, P462, DOI 10.1016/j.pragma.2006.07.007
   Schilbach L, 2013, BEHAV BRAIN SCI, V36, P393, DOI 10.1017/S0140525X12000660
   Schutz Alfred, 1967, PHENOMENOLOGY SOCIAL
   Schweikard David P., 2013, STANFORD ENCY PHILOS
   Scollon R., 1981, GEORGETOWN U ROUND T, P335
   SEARLE JOHN R., 1995, CONSTRUCTION SOCIAL
   Sebanz N, 2006, TRENDS COGN SCI, V10, P70, DOI 10.1016/j.tics.2005.12.009
   Service V., 1984, LANGUAGE DEV, P132
   Sterponi L, 2014, J CHILD LANG, V41, P275, DOI 10.1017/S0305000912000682
   Sheets- Johnstone M., 2011, PRIMACY PERCEPTION
   SHOTTER J, 1983, J THEOR SOC BEHAV, V13, P19, DOI 10.1111/j.1468-5914.1983.tb00460.x
   Stern D, 1977, 1 RELATIONSHIP INFAN
   Stern D., 1985, INTERPERSONAL WORLD
   Sterponi L, 2010, ETHOS, V38, P116, DOI 10.1111/j.1548-1352.2009.01084.x
   Streeck J., 2011, LANGUAGE BODY MAT WO, P1
   Stribling P., 2006, USSUES APPL LINGUIST, V15, P3
   Stribling P, 2009, CLIN LINGUIST PHONET, V23, P555, DOI 10.1080/02699200802491165
   Teasley S. D., 1993, COMPUTER COGNITIVE T
   Thelen E., 1994, DYNAMIC SYSTEMS APPR
   Thompson E., 2005, PHENOMENOLOGY COGNIT, V4, P407, DOI DOI 10.1007/S11097-005-9003-X
   Thompson E., 2007, MIND LIFE BIOL PHENO
   Tollefsen D, 2012, PHILOS PSYCHOL, V25, P385, DOI 10.1080/09515089.2011.579418
   Tollefsen D, 2005, PHILOS SOC SCI, V35, P75, DOI 10.1177/0048393104271925
   Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
   Tomasello M., 2009, CULTURAL ORIGINS HUM
   Tomasello M., 1995, JOINT ATTENTION ITS, P103
   Trevarthen C., 1979, SPEECH BEGINNING INT, P321
   TRONICK EZ, 1989, CHILD DEV, V60, P85, DOI 10.1111/j.1467-8624.1989.tb02698.x
   Tulbert E., 2011, EMBODIED INTERACTION, V79-92
   Tummolini L, 2014, PHENOMENOL COGN SCI, V13, P75, DOI 10.1007/s11097-013-9318-y
   Tuomela R., 1995, IMPORTANCE US PHILOS
   Tuomela R., 1993, ERKENNTNIS, V38, P87, DOI 10. 1007/ BF01129023
   Tuomela R, 2005, PHILOS STUD, V125, P327, DOI 10.1007/s11098-005-7781-1
   Tuomela R., 2000, COOPERATION PHILOS S, DOI [10.1007/978-94-015-9594-0, DOI 10.1007/978-94-015-9594-0]
   Varela F., 1991, EMBODIED MIND COGNIT
   Varela FJ, 1997, BRAIN COGNITION, V34, P72, DOI 10.1006/brcg.1997.0907
   VARELA FJ, 1991, BOST STUD PHILOS SCI, V129, P79
   Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
   Warneken F, 2007, INFANCY, V11, P271
   Warneken F, 2006, SCIENCE, V311, P1301, DOI 10.1126/science.1121448
   Warneken F, 2006, CHILD DEV, V77, P640, DOI 10.1111/j.1467-8624.2006.00895.x
   Warneken F, 2012, DEVELOPMENTAL SCI, V15, P54, DOI 10.1111/j.1467-7687.2011.01107.x
   Weber A., 2002, Phenomenology and the Cognitive Sciences, V1, DOI 10.1023/A:1020368120174
   Wootton A. J., 1999, FIRST LANG, V19, P359, DOI [10.1177/ 014272379901905704, DOI 10.1177/014272379901905704]
NR 132
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD AUG 8
PY 2014
VL 5
AR 874
DI 10.3389/fpsyg.2014.00874
PG 11
WC Psychology, Multidisciplinary
SC Psychology
GA AN8XM
UT WOS:000340889200001
PM 25152745
ER

PT J
AU Pakarinen, S
   Sokka, L
   Leinikka, M
   Henelius, A
   Korpela, J
   Huotilainen, M
AF Pakarinen, Satu
   Sokka, Laura
   Leinikka, Marianne
   Henelius, Andreas
   Korpela, Jussi
   Huotilainen, Minna
TI Fast determination of MMN and P3a responses to linguistically and
   emotionally relevant changes in pseudoword stimuli
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Mismatch negativity (MMN); Event-related potential (ERP); Multi-feature
   paradigm; Central auditory processing; Emotion; Language
ID MISMATCH NEGATIVITY MMN; INVOLUNTARY ATTENTION; BRAIN POTENTIALS;
   AUDITORY-STIMULI; SENSORY MEMORY; COMPLEX SOUND; DURATION; NOVELTY;
   P300; DISCRIMINATION
AB We developed a new multi-feature mismatch negativity (MMN) paradigm with two improvements: Firstly, the standard tone, a pseudoword /ta-ta/ was presented with equal probability to the nine linguistically relevant deviants, reducing the recording time by 45%. Secondly, three rare, emotionally valenced stimuli: happy, angry, and sad utterances of the standard pseudoword were included in the sequence. MMN signals reflecting the perceptual properties of the sounds were observed for all stimuli. In addition, P3a signals were observed for the rare emotionally uttered pseudowords. This 28-min paradigm allows a multi-dimensional evaluation of central speech-sound representations (MMN), and attention allocation (P3a) to emotional information content of speech. We recommend this paradigm for studies on subject groups with impairments in language or emotional information processing, such as autism spectrum disorders, attention disorders, and alexithymia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Pakarinen, Satu; Sokka, Laura; Leinikka, Marianne; Henelius, Andreas; Korpela, Jussi; Huotilainen, Minna] Finnish Inst Occupat Hlth, FI-00250 Helsinki, Finland.
RP Pakarinen, S (reprint author), Finnish Inst Occupat Hlth, Brain & Technol Team, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland.
EM satu.pakarinen@ttl.fi
FU SalWe Research Programme for Mind and Body [1104/10]
FX The authors thank RN Nina Lapvetelainen and Riitta Velin for their
   assistance in data collection. The present study was supported by the
   SalWe Research Programme for Mind and Body (Tekes - Grant 1104/10).
CR Alho K, 1997, NEUROREPORT, V8, P3233, DOI 10.1097/00001756-199710200-00010
   ALHO K, 1993, NEUROREPORT, V4, P391, DOI 10.1097/00001756-199304000-00012
   ALHO K, 1995, EAR HEARING, V16, P38, DOI 10.1097/00003446-199502000-00004
   Amenedo E, 2000, EUR J NEUROSCI, V12, P2570, DOI 10.1046/j.1460-9568.2000.00114.x
   Beauchemin M, 2006, EUR J NEUROSCI, V23, P3081, DOI 10.1111/j.1460-9568.2006.04856.x
   Denham SL, 2006, J PHYSIOLOGY-PARIS, V100, P154, DOI 10.1016/j.jphysparis.2006.09.012
   Deouell LY, 2007, J PSYCHOPHYSIOL, V21, P188, DOI 10.1027/0269-8803.21.34.188
   Duncan CC, 2009, CLIN NEUROPHYSIOL, V120, P1883, DOI 10.1016/j.clinph.2009.07.045
   Escera C, 2001, EUR J NEUROSCI, V14, P877, DOI 10.1046/j.0953-816x.2001.01707.x
   Escera C, 1998, J COGNITIVE NEUROSCI, V10, P590, DOI 10.1162/089892998562997
   Escera C, 2000, AUDIOL NEURO-OTOL, V5, P151, DOI 10.1159/000013877
   Friedman D, 2001, NEUROSCI BIOBEHAV R, V25, P355, DOI 10.1016/S0149-7634(01)00019-7
   FrodlBauch T, 1997, BRAIN TOPOGR, V10, P3, DOI 10.1023/A:1022214905452
   HARI R, 1984, NEUROSCI LETT, V50, P127, DOI 10.1016/0304-3940(84)90474-9
   Jacobsen T, 2003, NEUROSCI LETT, V344, P79, DOI 10.1016/S0304-3940(03)00408-7
   KNIGHT RT, 1989, BRAIN RES, V502, P109, DOI 10.1016/0006-8993(89)90466-6
   Leung S, 2012, PSYCHOPHYSIOLOGY, V49, P933, DOI 10.1111/j.1469-8986.2012.01375.x
   MCISAAC H, 1992, J EXP CHILD PSYCHOL, V53, P115, DOI 10.1016/0022-0965(92)90044-7
   Mecklinger A, 1995, NEUROREPORT, V7, P241, DOI 10.1097/00001756-199512000-00058
   NAATANEN R, 1993, NEUROREPORT, V4, P503
   Naatanen R., 1995, Brain Topography, V7, P315, DOI 10.1007/BF01195257
   NAATANEN R, 1978, ACTA PSYCHOL, V42, P313, DOI 10.1016/0001-6918(78)90006-9
   Naatanen R, 1997, NATURE, V385, P432, DOI 10.1038/385432a0
   Naatanen R, 2010, BRAIN RES REV, V64, P123, DOI 10.1016/j.brainresrev.2010.03.001
   Naatanen R, 1999, PSYCHOL BULL, V125, P826, DOI 10.1037/0033-2909.125.6.826
   Naatanen R, 2011, PSYCHOPHYSIOLOGY, V48, P4, DOI 10.1111/j.1469-8986.2010.01114.x
   Naatanen R, 2004, CLIN NEUROPHYSIOL, V115, P140, DOI 10.1016/j.clinph.2003.04.001
   Nousak JMK, 1996, COGNITIVE BRAIN RES, V4, P305, DOI 10.1016/S0926-6410(96)00068-7
   Nuske HJ, 2013, COGNITION EMOTION, V27, P1042, DOI 10.1080/02699931.2012.762900
   PAAVILAINEN P, 1993, BIOL PSYCHOL, V35, P139, DOI 10.1016/0301-0511(93)90010-6
   Pakarinen S, 2010, CLIN NEUROPHYSIOL, V121, P1043, DOI 10.1016/j.clinph.2010.02.009
   Pakarinen S, 2007, CLIN NEUROPHYSIOL, V118, P177, DOI 10.1016/j.clinph.2006.09.001
   Pakarinen S., 2009, BIOL PSYCHOL, V82, P126
   Peterson RL, 2012, LANCET, V379, P1997, DOI 10.1016/S0140-6736(12)60198-6
   Polich J, 2007, CLIN NEUROPHYSIOL, V118, P2128, DOI 10.1016/j.clinph.2007.04.019
   Sambeth A., 2008, CLIN NEUROPHYSIOL, V120, P530
   SAMS M, 1985, ELECTROEN CLIN NEURO, V62, P437, DOI 10.1016/0168-5597(85)90054-1
   SQUIRES NK, 1975, ELECTROEN CLIN NEURO, V38, P387, DOI 10.1016/0013-4694(75)90263-1
   Sussman E, 2001, COGNITIVE BRAIN RES, V12, P431, DOI 10.1016/S0926-6410(01)00067-2
   Sussman E.S., 2013, BRAIN TOPOGR
   TIITINEN H, 1994, NATURE, V372, P90, DOI 10.1038/372090a0
   Winkler I., 2009, TRENDS COGN SCI, V13, P340
   Winkler I, 1999, PSYCHOPHYSIOLOGY, V36, P638, DOI 10.1017/S0048577299981908
   Wronka E, 2012, ACTA NEUROBIOL EXP, V72, P51
   Wronka E, 2008, ACTA NEUROBIOL EXP, V68, P362
NR 45
TC 1
Z9 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD AUG 8
PY 2014
VL 577
BP 28
EP 33
DI 10.1016/j.neulet.2014.06.004
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA AN0XY
UT WOS:000340308500006
PM 24928223
ER

PT J
AU Manzini, MC
   Xiong, L
   Shaheen, R
   Tambunan, DE
   Di Costanzo, S
   Mitisalis, V
   Tischfield, DJ
   Cinquino, A
   Ghaziuddin, M
   Christian, M
   Jiang, Q
   Laurent, S
   Nanjiani, ZA
   Rasheed, S
   Hill, RS
   Lizarraga, SB
   Gleason, D
   Sabbagh, D
   Salih, MA
   Alkuraya, FS
   Walsh, CA
AF Manzini, M. Chiara
   Xiong, Lan
   Shaheen, Ranad
   Tambunan, Dimira E.
   Di Costanzo, Stefania
   Mitisalis, Vanessa
   Tischfield, David J.
   Cinquino, Antonella
   Ghaziuddin, Mohammed
   Christian, Mehtab
   Jiang, Qin
   Laurent, Sandra
   Nanjiani, Zohair A.
   Rasheed, Saima
   Hill, R. Sean
   Lizarraga, Sofia B.
   Gleason, Danielle
   Sabbagh, Diya
   Salih, Mustafa A.
   Alkuraya, Fowzan S.
   Walsh, Christopher A.
TI CC2D1A Regulates Human Intellectual and Social Function as well as
   NF-kappa B Signaling Homeostasis
SO CELL REPORTS
LA English
DT Article
ID NONSYNDROMIC MENTAL-RETARDATION; C2 DOMAIN PROTEIN; NOTCH; GENE;
   IDENTIFICATION; TRAFFICKING; PLASTICITY; DROSOPHILA; DISORDERS;
   RECEPTORS
AB Autism spectrum disorder (ASD) and intellectual disability (ID) are often comorbid, but the extent to which they share common genetic causes remains controversial. Here, we present two autosomal-recessive "founder" mutations in the CC2D1A gene causing fully penetrant cognitive phenotypes, including mild-to-severe ID, ASD, as well as seizures, suggesting shared developmental mechanisms. CC2D1A regulates multiple intracellular signaling pathways, and we found its strongest effect to be on the transcription factor nuclear factor kappa B (NF-kappa B). Cc2d1a gain and loss of function both increase activation of NF-kappa B, revealing a critical role of Cc2d1a in homeostatic control of intracellular signaling. Cc2d1a knockdown in neurons reduces dendritic complexity and increases NF-kappa B activity, and the effects of Cc2d1a depletion can be rescued by inhibiting NF-kappa B activity. Homeostatic regulation of neuronal signaling pathways provides a mechanism whereby common founder mutations could manifest diverse symptoms in different patients.
C1 [Manzini, M. Chiara; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Walsh, Christopher A.] Boston Childrens Hosp, Manton Ctr Orphan Dis Res, Div Genet & Genom, Boston, MA 02115 USA.
   [Manzini, M. Chiara; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Walsh, Christopher A.] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA.
   [Manzini, M. Chiara; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Walsh, Christopher A.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
   [Manzini, M. Chiara; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Walsh, Christopher A.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.
   [Xiong, Lan; Jiang, Qin] Univ Montreal, Montreal Mental Hlth Univ Inst, Res Ctr, Dept Psychiat, Montreal, PQ H1N 3V2, Canada.
   [Xiong, Lan; Christian, Mehtab; Laurent, Sandra] Univ Montreal Hosp, Res Ctr, Montreal, PQ H2L 2W5, Canada.
   [Shaheen, Ranad; Sabbagh, Diya; Alkuraya, Fowzan S.] King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia.
   [Ghaziuddin, Mohammed] Univ Michigan Hlth Syst, Dept Child & Adolescent Psychiat, Ann Arbor, MI 48109 USA.
   [Nanjiani, Zohair A.] Univ Karachi, Ma Ayesha Mem Ctr, Karachi 75350, Pakistan.
   [Rasheed, Saima] Autism Inst, Karachi 74000, Pakistan.
   [Salih, Mustafa A.] King Saud Univ, Coll Med, Dept Pediat, Div Pediat Neurol, Riyadh 11461, Saudi Arabia.
   [Walsh, Christopher A.] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA.
RP Salih, MA (reprint author), King Saud Univ, Coll Med, Dept Pediat, Div Pediat Neurol, Riyadh 11461, Saudi Arabia.
EM mustafa_salih05@yahoo.com; falkuraya@kfshrc.edu.sa;
   christopher.walsh@childrens.harvard.edu
FU NIH [R01MH083565, R01NS032457, R00HD067379]; Simons Foundation; KACST
   [13-BIO1113-20]; Centro per la Comunicazione e Ricerca del Collegio
   Ghislieri; Hearst Fund; Manton Center for Orphan Disease Research;
   Deanship of Scientific Research, King Saud University, Riyadh, Saudi
   Arabia [RGP-VPP-301]; Italian National Research Council; Giovanni
   Armenise-Harvard Foundation
FX The authors would like to thank the families for their constant
   availability and collaboration, Dilenny Gonzalez and Daniel Rakiec for
   technical help, Adria Bodell for help with patient recruitment, Tom
   Maynard at the George Washington University for help with qPCR, and the
   Genotyping and Sequencing Core Facility at KFSHRC for help with analysis
   of families 1 and 2. They are also grateful to Jenny Yang, Tim Yu, and
   Adam Oaks for helpful discussion. Research was supported by grants from
   the NIH (R01MH083565 and R01NS032457 to C.A.W. and R00HD067379 to
   M.C.M.) the Simons Foundation (to C.A.W.), and KACST (Grant
   13-BIO1113-20 to F.S.A.). M.C.M. was also supported by grants from the
   Centro per la Comunicazione e Ricerca del Collegio Ghislieri, the Hearst
   Fund, and the Manton Center for Orphan Disease Research. M.A.S. was
   supported by the Deanship of Scientific Research, King Saud University,
   Riyadh, Saudi Arabia through the research group project number
   RGP-VPP-301. A.C. was supported by a fellowship from the Italian
   National Research Council and the Giovanni Armenise-Harvard Foundation.
   C.A.W. is an Investigator of the Howard Hughes Medical Institute.
CR Al-Tawashi A, 2012, J BIOL CHEM, V287, P14644, DOI 10.1074/jbc.M111.261875
   Basel-Vanagaite L, 2006, J MED GENET, V43, P203, DOI 10.1136/jmg.2005.035709
   Bhakar AL, 2002, J NEUROSCI, V22, P8466
   Bonini SA, 2011, J NEUROSCI, V31, P11697, DOI 10.1523/JNEUROSCI.1113-11.2011
   Chang CH, 2011, J BIOL CHEM, V286, P7043, DOI 10.1074/jbc.M110.164632
   Chen KR, 2012, J BIOL CHEM, V287, P32216, DOI 10.1074/jbc.C112.394346
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators Centers for Disease Control and Prevention, 2014, MMWR SURVEILL SUMM, V63, P1
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Dixit E, 2010, CELL, V141, P668, DOI 10.1016/j.cell.2010.04.018
   Gallagher CM, 2006, DEV CELL, V11, P641, DOI 10.1016/j.devcel.2006.09.014
   Gavalda N, 2009, DEVELOPMENT, V136, P3405, DOI 10.1242/dev.035295
   Gutierrez H, 2008, J NEUROSCI, V28, P8246, DOI 10.1523/JNEUROSCI.1941-08.2008
   Hoffmann A, 2006, IMMUNOL REV, V210, P171, DOI 10.1111/j.0105-2896.2006.00375.x
   Jaekel R, 2006, DEV CELL, V11, P655, DOI 10.1016/j.devcel.2006.09.019
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   Martinelli N, 2012, J MOL BIOL, V419, P75, DOI 10.1016/j.jmb.2012.02.044
   Mattson MP, 2006, CELL DEATH DIFFER, V13, P852, DOI 10.1038/sj.cdd.4401837
   Meffert MK, 2003, NAT NEUROSCI, V6, P1072, DOI 10.1038/nn1110
   Mir A, 2009, AM J HUM GENET, V85, P909, DOI 10.1016/j.ajhg.2009.11.009
   Mochida GH, 2009, AM J HUM GENET, V85, P897, DOI 10.1016/j.ajhg.2009.10.027
   Nakamura A, 2009, J CELL BIOL, V187, P607, DOI 10.1083/jcb.200906019
   Olson EC, 2006, J NEUROSCI, V26, P1767, DOI 10.1523/JNEUROSCI.3000-05.2006
   O'Mahony A, 2006, MOL CELL BIOL, V26, P7283, DOI 10.1128/MCB.00510-06
   O'Riordan KJ, 2006, J NEUROSCI, V26, P4870, DOI 10.1523/JNEUROSCI.4527-05.2006
   Ou XM, 2003, J NEUROSCI, V23, P7415
   Philippe O, 2009, AM J HUM GENET, V85, P903, DOI 10.1016/j.ajhg.2009.11.007
   Salama-Cohen P, 2005, MOL BIOL CELL, V16, P339
   Shin HM, 2004, FEBS LETT, V571, P50, DOI 10.1016/j.febslet.2004.06.056
   Troost T, 2012, J CELL SCI, V125, P763, DOI 10.1242/jcs.097261
   Usami Y, 2012, J VIROL, V86, P3746, DOI 10.1128/JVI.06539-11
   Zhao M, 2010, J BIOL CHEM, V285, P24372, DOI 10.1074/jbc.M109.100057
   Zhao M, 2011, J NEUROPHYSIOL, V105, P1506, DOI 10.1152/jn.00950.2010
NR 33
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD AUG 7
PY 2014
VL 8
IS 3
BP 647
EP 655
DI 10.1016/j.celrep.2014.06.039
PG 9
WC Cell Biology
SC Cell Biology
GA AO7ZR
UT WOS:000341572200001
PM 25066123
ER

PT J
AU Wada, M
   Suzuki, M
   Takaki, A
   Miyao, M
   Spence, C
   Kansaku, K
AF Wada, Makoto
   Suzuki, Mayuko
   Takaki, Akiko
   Miyao, Masutomo
   Spence, Charles
   Kansaku, Kenji
TI Spatio-temporal processing of tactile stimuli in autistic children
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TEMPORAL-ORDER JUDGMENT; RUBBER HAND ILLUSION; SPECTRUM DISORDERS;
   REFERENCE FRAMES; BRAIN; PERCEPTION; SELF; REPRESENTATIONS; VISION;
   SPACE
AB Altered multisensory integration has been reported in autism; however, little is known concerning how the autistic brain processes spatio-temporal information concerning tactile stimuli. We report a study in which a crossed-hands illusion was investigated in autistic children. Neurotypical individuals often experience a subjective reversal of temporal order judgments when their hands are stimulated while crossed, and the illusion is known to be acquired in early childhood. However, under those conditions where the somatotopic representation is given priority over the actual spatial location of the hands, such reversals may not occur. Here, we showed that a significantly smaller illusory reversal was demonstrated in autistic children than in neurotypical children. Furthermore, in an additional experiment, the young boys who had higher Autism Spectrum Quotient (AQ) scores generally showed a smaller crossed hands deficit. These results suggest that rudimentary spatio-temporal processing of tactile stimuli exists in autistic children, and the altered processing may interfere with the development of an external frame of reference in real-life situations.
C1 [Wada, Makoto; Kansaku, Kenji] Natl Rehabil Ctr Persons Disabil, Inst Res, Dept Rehabil Brain Funct, Syst Neurosci Sect, Tokorozawa, Saitama 3598555, Japan.
   [Wada, Makoto] Natl Rehabil Ctr Persons Disabil, Inst Res, Dept Rehabil Brain Funct, Dev Disorders Sect, Tokorozawa, Saitama 3598555, Japan.
   [Miyao, Masutomo] Natl Ctr Child Hlth & Dev, Dept Med Psychol, Div Dev Neuropsychol, Tokyo, Tokyo 1578535, Japan.
   [Spence, Charles] Univ Oxford, Dept Expt Psychol, Crossmodal Res Lab, Oxford OX1 3UD, England.
   [Kansaku, Kenji] Univ Electrocommun, Brain Sci Inspired Life Support Res, Tokyo 1828585, Japan.
RP Kansaku, K (reprint author), Natl Rehabil Ctr Persons Disabil, Inst Res, Dept Rehabil Brain Funct, Syst Neurosci Sect, Tokorozawa, Saitama 3598555, Japan.
EM kansaku-kenji@rehab.go.ip
FU MEXT [23300151]
FX This study was partly supported by a MEXT grant (#23300151) to K.
   Kansaku. We would like to thank S. Iwama for technical assistance; H.
   Hirose, H. Agarie, S. Kim and S. Kitazawa for their valuable comments;
   and Y. Nakajima and S. Kato for their continuous encouragement.
CR ANDERSEN RA, 1985, SCIENCE, V230, P456, DOI 10.1126/science.4048942
   Armel KC, 2003, P ROY SOC B-BIOL SCI, V270, P1499, DOI 10.1098/rspb.2003.2364
   Azanon E, 2008, CURR BIOL, V18, P1044, DOI 10.1016/j.cub.2008.06.045
   Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen Simon, 2005, Cogn Neuropsychiatry, V10, P77, DOI 10.1080/13546800344000336
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Blanke O, 2002, NATURE, V419, P269, DOI 10.1038/419269a
   Blanke O, 2012, NAT REV NEUROSCI, V13, P556, DOI 10.1038/nrn3292
   Botvinick M, 1998, NATURE, V391, P756, DOI 10.1038/35784
   Bremner A., 2012, MULTISENSORY DEV, P114
   Burgess N, 2008, ANN NY ACAD SCI, V1124, P77, DOI 10.1196/annals.1440.002
   Burnett CT, 1904, PSYCHOL REV, V11, P370, DOI 10.1037/h0074642
   Cadieux ML, 2010, EXP BRAIN RES, V204, P431, DOI 10.1007/s00221-010-2268-5
   Cascio CJ, 2012, AUTISM, V16, P406, DOI 10.1177/1362361311430404
   Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
   Davis B, 2009, J NEUROSCI, V29, P3182, DOI 10.1523/JNEUROSCI.5793-08.2009
   Donohue SE, 2012, EXP BRAIN RES, V222, P377, DOI 10.1007/s00221-012-3223-4
   Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
   Frith U, 2005, CONSCIOUS COGN, V14, P719, DOI 10.1016/j.concog.2005.04.006
   Galati G, 2010, EXP BRAIN RES, V206, P109, DOI 10.1007/s00221-010-2168-8
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
   Hill E., 2012, MULTISENSORY DEV, P273
   Klatzky R. L., 1998, LECT NOTES ARTIF INT, V1404, P1
   Kwakye Leslie D, 2011, Front Integr Neurosci, V4, P129, DOI 10.3389/fnint.2010.00129
   Ley P, 2013, NEUROPSYCHOLOGIA, V51, P1119, DOI 10.1016/j.neuropsychologia.2013.03.004
   Linkenauger SA, 2012, AUTISM RES, V5, P352, DOI 10.1002/aur.1248
   Lloyd DM, 2003, NAT NEUROSCI, V6, P17, DOI 10.1038/nn991
   Lombardo MV, 2010, J COGNITIVE NEUROSCI, V22, P1623, DOI 10.1162/jocn.2009.21287
   Neggers SFW, 2006, NEUROIMAGE, V31, P320, DOI 10.1016/j.neuroimage.2005.12.028
   Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
   OHTA M, 1987, J AUTISM DEV DISORD, V17, P45, DOI 10.1007/BF01487259
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Pagel B, 2009, DEVELOPMENTAL SCI, V12, P929, DOI 10.1111/j.1467-7687.2009.00845.x
   Parmentier FBR, 2006, PSYCHOL RES-PSYCH FO, V70, P200, DOI 10.1007/s00426-004-0212-7
   Paton B, 2012, J AUTISM DEV DISORD, V42, P1870, DOI 10.1007/s10803-011-1430-7
   Pellijeff A, 2006, NEUROPSYCHOLOGIA, V44, P2685, DOI 10.1016/j.neuropsychologia.2006.01.009
   Rizzolatti G, 2010, EXP BRAIN RES, V200, P223, DOI 10.1007/s00221-009-2002-3
   Roder B, 2007, P NATL ACAD SCI USA, V104, P4753, DOI 10.1073/pnas.0607158104
   Roder B, 2004, CURR BIOL, V14, P121, DOI 10.1016/j.cub.2003.12.054
   Shore DI, 2002, COGNITIVE BRAIN RES, V14, P153, DOI 10.1016/S0926-6410(02)00070-8
   Sirigu A, 1999, BRAIN, V122, P1867, DOI 10.1093/brain/122.10.1867
   Snyder LH, 1998, NATURE, V394, P887
   Sugranyes G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025322
   Takahashi T, 2013, CEREB CORTEX, V23, P1952, DOI 10.1093/cercor/bhs179
   Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-19
   Tsakiris M, 2005, J EXP PSYCHOL HUMAN, V31, P80, DOI 10.1037/0096-1523.31.1.80
   Van Riper C, 1935, AM J PSYCHOL, V47, P252
   Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
   Wada M, 2004, NEUROPSYCHOLOGIA, V42, P1887, DOI 10.1016/j.neuropsychologia.2004.05.009
   Wada M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039800
   Wakabayashi Akio, 2004, Shinrigaku Kenkyu, V75, P78
   WIELAND BA, 1960, AM J PSYCHOL, V73, P248, DOI 10.2307/1419901
   Williams JHG, 2008, AUTISM RES, V1, P73, DOI 10.1002/aur.15
   Wolpert DM, 1998, NAT NEUROSCI, V1, P529, DOI 10.1038/2245
   Yamamoto S, 2001, NAT NEUROSCI, V4, P759, DOI 10.1038/89559
   Zaehle T, 2007, BRAIN RES, V1137, P92, DOI 10.1016/j.brainres.2006.12.044
NR 59
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 7
PY 2014
VL 4
AR 5985
DI 10.1038/srep05985
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM7GL
UT WOS:000340033300008
PM 25100146
ER

PT J
AU Yasuda, Y
   Hashimoto, R
   Fukai, R
   Okamoto, N
   Hiraki, Y
   Yamamori, H
   Fujimoto, M
   Ohi, K
   Taniike, M
   Mohri, I
   Nakashima, M
   Tsurusaki, Y
   Saitsu, H
   Matsumoto, N
   Miyake, N
   Takeda, M
AF Yasuda, Yuka
   Hashimoto, Ryota
   Fukai, Ryoko
   Okamoto, Nobuhiko
   Hiraki, Yoko
   Yamamori, Hidenaga
   Fujimoto, Michiko
   Ohi, Kazutaka
   Taniike, Masako
   Mohri, Ikuko
   Nakashima, Mitsuko
   Tsurusaki, Yoshinori
   Saitsu, Hirotomo
   Matsumoto, Naomichi
   Miyake, Noriko
   Takeda, Masatoshi
TI Duplication of the NPHP1 gene in patients with autism spectrum disorder
   and normal intellectual ability: a case series
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; Copy-number variants; Duplication;
   Nephronophthisis 1 gene; Intelligence
ID PERVASIVE DEVELOPMENTAL DISORDERS; COPY-NUMBER VARIATION; JOUBERT
   SYNDROME; DE-NOVO; NEPHRONOPHTHISIS; DISABILITIES; INDIVIDUALS;
   PREVALENCE; CHILDREN; NETWORK
AB Autism spectrum disorder is a neurodevelopmental disorder characterized by impairments in social interactions, reduced verbal communication abilities, stereotyped repetitive behaviors, and restricted interests. It is a complex condition caused by genetic and environmental factors; the high heritability of this disorder supports the presence of a significant genetic contribution. Many studies have suggested that copy-number variants contribute to the etiology of autism spectrum disorder. Recently, copy-number variants of the nephronophthisis 1 gene have been reported in patients with autism spectrum disorder. To the best of our knowledge, only six autism spectrum disorder cases with duplications of the nephronophthisis 1 gene have been reported. These patients exhibited intellectual dysfunction, including verbal dysfunction in one patient, below-average verbal intellectual ability in one patient, and intellectual disability in four patients.
   In this study, we identified nephronophthisis 1 duplications in two unrelated Japanese patients with autism spectrum disorder using a high-resolution single-nucleotide polymorphism array. This report is the first to describe a nephronophthisis 1 duplication in an autism spectrum disorder patient with an average verbal intelligence quotient and an average performance intelligence quotient. However, the second autism spectrum disorder patient with a nephronophthisis 1 duplication had a below-average performance intelligence quotient. Neither patient exhibited physical dysfunction, motor developmental delay, or neurological abnormalities. This study supports the clinical observation of nephronophthisis 1 duplication in autism spectrum disorder cases and might contribute to our understanding of the clinical phenotype that arises from this duplication.
C1 [Yasuda, Yuka; Hashimoto, Ryota; Yamamori, Hidenaga; Fujimoto, Michiko; Ohi, Kazutaka; Takeda, Masatoshi] Osaka Univ, Grad Sch Med, Dept Psychiat, Suita, Osaka 5650871, Japan.
   [Hashimoto, Ryota; Taniike, Masako; Mohri, Ikuko] Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, Suita, Osaka 5650871, Japan.
   [Fukai, Ryoko] Yokohama City Univ, Grad Sch Med, Dept Human Genet, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan.
   [Fukai, Ryoko; Nakashima, Mitsuko; Tsurusaki, Yoshinori; Saitsu, Hirotomo; Matsumoto, Naomichi; Miyake, Noriko] Yokohama City Univ, Grad Sch Med, Dept Neurol & Stroke Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan.
   [Okamoto, Nobuhiko] Osaka Med Ctr, Div Med Genet, Izumi 5941101, Japan.
   [Okamoto, Nobuhiko] Res Inst Maternal & Child Hlth, Izumi 5941101, Japan.
   [Hiraki, Yoko] Hiroshima Municipal Ctr Child Hlth & Dev, Hiroshima 7320052, Japan.
   [Yamamori, Hidenaga] Osaka Univ, Grad Sch Med, Dept Mol Neuropsychiat, Suita, Osaka 5650871, Japan.
RP Hashimoto, R (reprint author), Osaka Univ, Grad Sch Med, Dept Psychiat, D3,2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM hashimor@psy.med.osaka-u.ac.jp
RI Hashimoto, Ryota/P-8572-2014
OI Hashimoto, Ryota/0000-0002-5941-4238
FU Japanese Ministry of Health, Labor, and Welfare [H22-seishin-ippan-001,
   H23-jitsuyouka (nanbyo)-ippan-005, H25-shinkei kin-ippan-001]; Japan
   Society for the Promotion of Science (JSPS) [24249019, 22390225,
   25293250, 25293085, 25293235, 24591680]; Challenging Exploratory
   Research grant [23659565]; Japanese Ministry of Education, Culture,
   Sports, Science, and Technology (MEXT) [25129704, 12024421, 18023045];
   Strategic Research Program for Brain Sciences [11105137]; Fund for the
   Creation of Innovation Centers for Advanced Interdisciplinary Research
   Areas Program in the Project for Developing Innovation Systems; Japan
   Foundation for Neuroscience and Mental Health; Takeda Science Foundation
FX We thank the patients and their families for participating in this
   study. Additionally, we thank Ms. Y. Yamashita, Ms. E. Koike, Ms. S.
   Sugimoto, Ms. N. Watanabe, and Ms. K. Takabe for their technical
   assistance. This work was supported by research grants from the Japanese
   Ministry of Health, Labor, and Welfare (H22-seishin-ippan-001,
   H23-jitsuyouka (nanbyo)-ippan-005, H25-shinkei kin-ippan-001), the Japan
   Society for the Promotion of Science (JSPS) through a Grant-in-Aid for
   Scientific Research [(A) (24249019), (B) (22390225, 25293250, 25293085,
   and 25293235), and (C) (24591680)] and a Challenging Exploratory
   Research grant (23659565), the Japanese Ministry of Education, Culture,
   Sports, Science, and Technology (MEXT) through a Grant-in-Aid for
   Scientific Research in Innovative Areas (Comprehensive Brain Science
   Network, 25129704) (Transcription Cycle, 12024421), Priority
   Areas-Research on the Pathomechanisms of Brain Disorders (18023045), the
   Strategic Research Program for Brain Sciences (11105137), the Fund for
   the Creation of Innovation Centers for Advanced Interdisciplinary
   Research Areas Program in the Project for Developing Innovation Systems,
   the Japan Foundation for Neuroscience and Mental Health, and the Takeda
   Science Foundation.
CR Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Baris H, 2006, AM J MED GENET A, V140A, P1876, DOI 10.1002/ajmg.a.31390
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
   Doherty D, 2009, SEMIN PEDIATR NEUROL, V16, P143, DOI 10.1016/j.spen.2009.06.002
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
   Kaminsky EB, 2011, GENET MED, V13, P777, DOI 10.1097/GIM.0b013e31822c79f9
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Roberts JL, 2014, GENE, V535, P70, DOI 10.1016/j.gene.2013.10.020
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sang LY, 2011, CELL, V145, P513, DOI 10.1016/j.cell.2011.04.019
   Saunier S, 2000, AM J HUM GENET, V66, P778, DOI 10.1086/302819
   Tory K, 2007, J AM SOC NEPHROL, V18, P1566, DOI 10.1681/ASN.2006101164
   Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
   Wakabayashi Akio, 2004, Shinrigaku Kenkyu, V75, P78
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
   Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x
   Yasuda Y, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-9
NR 23
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD AUG 6
PY 2014
VL 13
AR 22
DI 10.1186/s12991-014-0022-2
PG 5
WC Psychiatry
SC Psychiatry
GA AN9EO
UT WOS:000340909000001
PM 25126106
ER

PT J
AU Kulesskaya, N
   Karpova, NN
   Ma, L
   Tian, L
   Voikar, V
AF Kulesskaya, Natalia
   Karpova, Nina N.
   Ma, Li
   Tian, Li
   Voikar, Vootele
TI Mixed housing with DBA/2 mice induces stress in C57BL/6 mice:
   implications for interventions based on social enrichment
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE animal model; stress; mixed housing; stress-related genes; behavioral
   interventions; social enrichment; social learning
ID INBRED MOUSE STRAINS; BEHAVIORAL TASKS RELEVANT; BTBR-T+TF/J MICE;
   DEFEAT STRESS; GLUCOCORTICOID-RECEPTOR; EPIGENETIC REGULATION;
   ALZHEIMERS-DISEASE; ADRENAL AXIS; DEPRESSION; AUTISM
AB Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in social support need further investigation. We took advantage of known differences between inbred mouse strains to reveal the effect of social enrichment on behavior and neurobiology of animals with different behavioral phenotypes. C57BL/6 and DBA/2 female mice displaying multiple differences in cognitive, social, and emotional behavior were group-housed either in same-strain or in mixed-strain conditions. Comprehensive behavioral phenotyping and analysis of expression of several plasticity- and stress-related genes were done to measure the reciprocal effects of social interaction between the strains. Contrary to our expectation, mixed housing did not change the behavior of DBA/2 mice. Nevertheless, the level of serum corticosterone and the expression of glucocorticoid receptor Nr3c1 in the brain were increased in mixed housed DBA/2 as compared with those of separately housed DBA/2 mice. In contrast, socially active C57BL/6 animals were more sensitive to the mixed housing, displaying several signs of stress: alterations in learning, social, and anxiety-like behavior and anhedonia. These behavioral impairments were accompanied by the elevated serum corticosterone and the reduced expression of Nr3c1, as well as the elevated Bdnf levels in the cortex and hippocampus. Our results demonstrate the importance of social factors in modulation of both behavior and the underlying neurobiological mechanisms in stress response, and draw attention to the potential negative impact of social interventions for individuals involved in social support.
C1 [Kulesskaya, Natalia; Karpova, Nina N.; Ma, Li; Tian, Li; Voikar, Vootele] Univ Helsinki, Ctr Neurosci, FIN-00014 Helsinki, Finland.
RP Kulesskaya, N (reprint author), Univ Helsinki, Ctr Neurosci, POB 56,Viikinkaari 4, FIN-00014 Helsinki, Finland.
EM natalia.kulesskaya@helsinki.fi; nina.karpova@helsinki.fi
FU Biocenter Finland; Helsinki graduate program in biotechnology and
   molecular biology; Ida Montinin saasto; Academy of Finland
FX This work was supported by Biocenter Finland, Helsinki graduate program
   in biotechnology and molecular biology, Ida Montinin saasto and Academy
   of Finland. We would like to thank Prof. Heikki Rauvala for critical
   reading and discussion, and Sissi Pastell for animal care.
CR Aid T, 2007, J NEUROSCI RES, V85, P525, DOI 10.1002/jnr.21139
   Arajarvi R, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-6
   Benarroch EE, 2013, NEUROLOGY, V80, P1521, DOI 10.1212/WNL.0b013e31828cfb15
   Blanchard RJ, 2001, PHYSIOL BEHAV, V73, P261, DOI 10.1016/S0031-9384(01)00449-8
   Boerboom W, 2014, J REHABIL MED, V46, P321, DOI 10.2340/16501977-1273
   Bouwknecht JA, 2002, BEHAV BRAIN RES, V136, P489, DOI 10.1016/S0166-4328(02)00200-0
   Bowman S, 2014, EARLY INTERV PSYCHIA, V8, P269, DOI 10.1111/eip.12068
   Boyle MP, 2005, P NATL ACAD SCI USA, V102, P473, DOI 10.1073/pnas.0406458102
   Branchi I, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062226
   Branchi I, 2010, PSYCHONEUROENDOCRINO, V35, P743, DOI 10.1016/j.psyneuen.2009.10.016
   Brown RE, 1999, PHYSIOL BEHAV, V67, P599, DOI 10.1016/S0031-9384(99)00109-2
   Buwalda B, 2005, NEUROSCI BIOBEHAV R, V29, P83, DOI 10.1016/j.neubiorev.2004.05.005
   Cabib S, 2002, BEHAV BRAIN RES, V130, P103, DOI 10.1016/S0166-4328(01)00422-3
   Cabib S, 2012, REV NEUROSCIENCE, V23, P659, DOI 10.1515/revneuro-2012-0080
   Campeau S, 2011, STRESS, V14, P503, DOI 10.3109/10253890.2011.596864
   Cantor-Graae E, 2007, CAN J PSYCHIAT, V52, P277
   Castren E, 2007, CURR OPIN PHARMACOL, V7, P18, DOI 10.1016/j.coph.2006.08.009
   Chourbaji Sabine, 2008, Prog Brain Res, V167, P65
   Crawley JN, 1997, PSYCHOPHARMACOLOGY, V132, P107, DOI 10.1007/s002130050327
   Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
   Curley JP, 2010, BEHAV GENET, V40, P220, DOI 10.1007/s10519-010-9334-4
   del-Pino-Casado R, 2011, J ADV NURS, V67, P2311, DOI 10.1111/j.1365-2648.2011.05725.x
   Der-Avakian A, 2012, TRENDS NEUROSCI, V35, P68, DOI 10.1016/j.tins.2011.11.005
   DeVries AC, 2002, HORM BEHAV, V41, P405, DOI 10.1006/hbeh.2002.1780
   Duff MC, 2013, J COMP NEUROL, V521, P4356, DOI 10.1002/cne.23433
   Ebstein RP, 2012, HORM BEHAV, V61, P359, DOI 10.1016/j.yhbeh.2011.12.014
   Fish E, 2010, TCE-THE CHEM ENG, P2
   Gamliel I, 2009, J AUTISM DEV DISORD, V39, P1131, DOI 10.1007/s10803-009-0727-2
   Golden SA, 2011, NAT PROTOC, V6, P1183, DOI 10.1038/nprot.2011.361
   Haller J, 2004, PSYCHOPHARMACOLOGY, V174, P197, DOI 10.1007/s00213-003-1746-x
   Hill MN, 2012, NEUROSCI BIOBEHAV R, V36, P2085, DOI 10.1016/j.neubiorev.2012.07.001
   Holmes A, 2002, GENES BRAIN BEHAV, V1, P55, DOI 10.1046/j.1601-1848.2001.00005.x
   Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
   Jezova D, 1995, ANN NY ACAD SCI, V771, P192, DOI 10.1111/j.1749-6632.1995.tb44681.x
   Kaplan G, 2012, PEDIATR CLIN N AM, V59, P175, DOI 10.1016/j.pcl.2011.10.005
   Karelina K, 2011, PSYCHOSOM MED, V73, P67, DOI 10.1097/PSY.0b013e3182002116
   Karelina K, 2009, P NATL ACAD SCI USA, V106, P5895, DOI 10.1073/pnas.0810737106
   Karpova NN, 2014, NEUROPHARMACOLOGY, V76, P709, DOI 10.1016/j.neuropharm.2013.04.002
   Karpova NN, 2009, EUR NEUROPSYCHOPHARM, V19, P97, DOI 10.1016/j.euroneuro.2008.09.002
   Kern RS, 2009, SCHIZOPHRENIA BULL, V35, P347, DOI 10.1093/schbul/sbn177
   KESSLER RC, 1985, ANNU REV PSYCHOL, V36, P531, DOI 10.1146/annurev.ps.36.020185.002531
   Kiryk A, 2011, CURR ALZHEIMER RES, V8, P883
   Kobayashi Y, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00017
   Krackow S, 2010, GENES BRAIN BEHAV, V9, P722, DOI 10.1111/j.1601-183X.2010.00606.x
   Kulesskaya N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066896
   Kulesskaya N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024755
   Kundakovic Marija, 2013, Front Psychiatry, V4, P78, DOI 10.3389/fpsyt.2013.00078
   Lipina TV, 2013, NEUROPHARMACOLOGY, V64, P283, DOI 10.1016/j.neuropharm.2012.06.054
   Lubin FD, 2008, J NEUROSCI, V28, P10576, DOI 10.1523/JNEUROSCI.1786-08.2008
   Lukas M, 2013, BEHAV BRAIN RES, V251, P85, DOI 10.1016/j.bbr.2012.08.011
   Magliano L, 2000, SOC PSYCH PSYCH EPID, V35, P109
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   McGowan PO, 2009, NAT NEUROSCI, V12, P342, DOI 10.1038/nn.2270
   Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015
   Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
   Mozhui K, 2010, J NEUROSCI, V30, P5357, DOI 10.1523/JNEUROSCI.5017-09.2010
   Naert G, 2011, MOL CELL NEUROSCI, V46, P55, DOI 10.1016/j.mcn.2010.08.006
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   O' Brien Irene, 2009, Br J Nurs, V18, P1360
   Olivier B, 2001, PSYCHOPHARMACOLOGY, V156, P284, DOI 10.1007/s002130100828
   Papaleo F, 2011, LEARN MEMORY, V18, P534, DOI 10.1101/lm.2213711
   Pattij T, 2007, GENES BRAIN BEHAV, V6, P579, DOI 10.1111/j.1601-183X.2006.00284.x
   Perkovic N. M., 2014, PSYCHOPHARMACOLOGY B, DOI [10.1007/s00213-014-3515-4, DOI 10.1007/S00213-014-3515-4]
   Pinkston JW, 2011, BEHAV NEUROSCI, V125, P194, DOI 10.1037/a0022919
   Pulkki-Raback L, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-236
   Razzoli M, 2011, BEHAV BRAIN RES, V216, P100, DOI 10.1016/j.bbr.2010.07.014
   Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
   Sadowsky CH, 2012, J AM BOARD FAM MED, V25, P350, DOI 10.3122/jabfm.2012.03.100183
   Sapolsky R M, 1985, Brain Res, V350, P169
   Satoh Y, 2011, J NEUROSCI, V31, P11953, DOI 10.1523/JNEUROSCI.2349-11.2011
   Schmidt MV, 2010, HORM BEHAV, V57, P415, DOI 10.1016/j.yhbeh.2010.01.010
   Schmidt MV, 2007, PSYCHONEUROENDOCRINO, V32, P417, DOI 10.1016/j.psyneuen.2007.02.011
   Shaked M, 2006, AUTISM, V10, P173, DOI 10.1177/1362361306062023
   SHANKS N, 1988, BEHAV NEUROSCI, V102, P894, DOI 10.1037//0735-7044.102.6.894
   Sharpe D, 2002, J PEDIATR PSYCHOL, V27, P699, DOI 10.1093/jpepsy/27.8.699
   Singer P, 2009, PSYCHOPHARMACOLOGY, V206, P677, DOI 10.1007/s00213-009-1568-6
   Slattery DA, 2012, PSYCHONEUROENDOCRINO, V37, P702, DOI 10.1016/j.psyneuen.2011.09.002
   Sokolowska E., 2013, NEUR M PLANN SAN DIE
   Soliman F, 2010, SCIENCE, V327, P863, DOI 10.1126/science.1181886
   Southwick SM, 2005, ANNU REV CLIN PSYCHO, V1, P255, DOI 10.1146/annurev.clinpsy.1.102803.143948
   Steele A, 2010, J AFFECT DISORDERS, V121, P10, DOI 10.1016/j.jad.2009.04.020
   TOLLIVER BK, 1994, PHARMACOL BIOCHEM BE, V48, P169, DOI 10.1016/0091-3057(94)90513-4
   Tulogdi A, 2014, DEV PSYCHOBIOL, V56, P49, DOI 10.1002/dev.21090
   UPCHURCH M, 1988, PHARMACOL BIOCHEM BE, V29, P325, DOI 10.1016/0091-3057(88)90164-5
   Van Os J, 2003, BRIT J PSYCHIAT, V182, P291, DOI 10.1192/bjp.182.4.291
   van Tilborg IADA, 2011, NEUROREHABILITATION, V29, P295, DOI 10.3233/NRE-2011-0705
   Voikar V, 2005, GENES BRAIN BEHAV, V4, P240, DOI 10.1111/j.1601-183X.2004.00103.x
   Walker M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077541
   Wang JS, 2013, NEUROPSYCHOPHARMACOL, V38, P2286, DOI 10.1038/npp.2013.130
   WEINBERGER SB, 1992, BEHAV GENET, V22, P177, DOI 10.1007/BF01066996
   Wittenberg E, 2013, MED DECIS MAKING, V33, P235, DOI 10.1177/0272989X12464434
   Yang M, 2011, AUTISM RES, V4, P17, DOI 10.1002/aur.163
   Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008
   Zhang L., 2013, MOL PSYCHIATR, V19, P8, DOI DOI 10.1038/MP.2012.180
   Zhang Tie Yuan, 2013, Neuropsychopharmacology, V38, P111, DOI 10.1038/npp.2012.149
NR 95
TC 3
Z9 3
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD AUG 6
PY 2014
VL 8
AR 257
DI 10.3389/fnbeh.2014.00257
PG 15
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AN9BZ
UT WOS:000340902200001
PM 25147512
ER

PT J
AU Kennedy, DP
   Adolphs, R
AF Kennedy, Daniel P.
   Adolphs, Ralph
TI Violations of Personal Space by Individuals with Autism Spectrum
   Disorder
SO PLOS ONE
LA English
DT Article
ID SOCIAL-BEHAVIOR; DIAGNOSTIC INTERVIEW; ETHOLOGICAL APPROACH; AMYGDALA;
   CHILDREN; ADOLESCENTS; TRAITS; BRAIN
AB The ability to maintain an appropriate physical distance (i.e., interpersonal distance) from others is a critical aspect of social interaction and contributes importantly to real-life social functioning. In Study 1, using parent-report data that had been acquired on a large number of individuals (ages 4-18 years) for the Autism Genetic Resource Exchange and the Simons Simplex Collection, we found that those with Autism Spectrum Disorder (ASD; n = 766) more often violated the space of others compared to their unaffected siblings (n = 766). This abnormality held equally across ASD diagnostic categories, and correlated with clinical measures of communication and social functioning. In Study 2, laboratory experiments in a sample of high-functioning adults with ASD demonstrated an altered relationship between interpersonal distance and personal space, and documented a complete absence of personal space in 3 individuals with ASD. Furthermore, anecdotal self-report from several participants confirmed that violations of social distancing conventions continue to occur in real-world interactions through adulthood. We suggest that atypical social distancing behavior offers a practical and sensitive measure of social dysfunction in ASD, and one whose psychological and neurological substrates should be further investigated.
C1 [Kennedy, Daniel P.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
   [Kennedy, Daniel P.; Adolphs, Ralph] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
   [Adolphs, Ralph] CALTECH, Div Biol, Pasadena, CA 91125 USA.
RP Kennedy, DP (reprint author), Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
EM dpk@indiana.edu; radolphs@hss.caltech.edu
FU Simons Foundation [SFARI-07-01]; National Institute of Mental Health
   [R01 MH080721]; Tamagawa University global Centers of Excellence program
   of the Japanese Ministry of Education, Culture, Sports and Technology
FX This work was supported by the Simons Foundation (SFARI-07-01 to R.A.),
   the National Institute of Mental Health (R01 MH080721 to R.A.), and the
   Tamagawa University global Centers of Excellence program of the Japanese
   Ministry of Education, Culture, Sports and Technology. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR BAUMAN M, 1985, NEUROLOGY, V35, P866
   Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   DONNELLAN AM, 1984, J AUTISM DEV DISORD, V14, P205, DOI 10.1007/BF02409663
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   Garfin DG, 1986, SOCIAL BEHAV AUTISM
   Gessaroli E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074959
   Hall E.T., 1966, HIDDEN DIMENSION
   HAYDUK LA, 1978, PSYCHOL BULL, V85, P117, DOI 10.1037//0033-2909.85.1.117
   Howlin P, 1986, SOCIAL BEHAV AUTISM
   Kennedy DP, 2009, NAT NEUROSCI, V12, P1226, DOI 10.1038/nn.2381
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1986, J AUTISM DEV DISORD, V16, P249, DOI 10.1007/BF01531658
   McGee GG, 1997, J AUTISM DEV DISORD, V27, P353, DOI 10.1023/A:1025849220209
   NESBITT PD, 1974, SOCIOMETRY, V37, P105, DOI 10.2307/2786470
   Parsons S, 2004, J AUTISM DEV DISORD, V34, P449, DOI 10.1023/B:JADD.0000037421.98517.8d
   PEDERSEN J, 1989, ACTA PSYCHIAT SCAND, V80, P346, DOI 10.1111/j.1600-0447.1989.tb02991.x
   Pelphrey K, 2004, MENT RETARD DEV D R, V10, P259, DOI 10.1002/mrdd
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
   Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
   VANENGELAND H, 1985, J CHILD PSYCHOL PSYC, V26, P879
NR 26
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 6
PY 2014
VL 9
IS 8
AR e103369
DI 10.1371/journal.pone.0103369
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM6SM
UT WOS:000339995100019
PM 25100326
ER

PT J
AU Paterson, C
   Law, AJ
AF Paterson, Clare
   Law, Amanda J.
TI Transient Overexposure of Neuregulin 3 during Early Postnatal
   Development Impacts Selective Behaviors in Adulthood
SO PLOS ONE
LA English
DT Article
ID EPIDERMAL-GROWTH-FACTOR; DEVELOPING NEOCORTEX; RECOGNITION MEMORY;
   PREFRONTAL CORTEX; ANIMAL-MODEL; SCHIZOPHRENIA; MICE; RECEPTOR;
   SUSCEPTIBILITY; INTERNEURONS
AB Neuregulin 3 (NRG3), a specific ligand for ErbB4 and a neuronal-enriched neurotrophin is implicated in the genetic predisposition to a broad spectrum of neurodevelopmental, neurocognitive and neuropsychiatric disorders, including Alzheimer's disease, autism and schizophrenia. Genetic studies in schizophrenia demonstrate that risk variants in NRG3 are associated with cognitive and psychotic symptom severity, accompanied by increased expression of prefrontal cortical NRG3. Despite our expanding knowledge of genetic involvement of NRG3 in neurological disorders, little is known about the neurodevelopmental mechanisms of risk. Here we exploited the fact that a paralog of NRG3, NRG1, readily penetrates the murine blood brain barrier (BBB). In this study we synthesized the bioactive epidermal growth factor (EGF) domain of NRG3, and using previously validated in-vivo peripheral injection methodologies in neonatal mice, demonstrate that NRG3 successfully crosses the BBB, where it activates its receptor ErbB4 and downstream Akt signaling at levels of bioactivity comparable to NRG1. To determine the impact of NRG3 overexpression during one critical developmental window, C57BL/6 male mice were subcutaneously injected daily with NRG1-EGF, NRG3-EGF or vehicle from postnatal days 2-10. Mice were tested in adulthood using a comprehensive battery of behavioral tasks relevant to neurocognitive and psychiatric disorders. In agreement with previous studies, developmental overexposure to NRG1 induced multiple non-CNS mediated peripheral effects as well as severely disrupting performance of prepulse inhibition of the startle response. In contrast, NRG3 had no effect on any peripheral measures investigated or sensorimotor gating. Specifically, developmental NRG3 overexposure produced an anxiogenic-like phenotype and deficits in social behavior in adulthood. These results provide primary data to support a role for NRG3 in brain development and function, which appears to be distinct from its paralog NRG1. Furthermore we demonstrate how perturbations in NRG3 expression at distinct developmental stages may contribute to the neurological deficits observed in brain disorders such as schizophrenia and autism.
C1 [Paterson, Clare; Law, Amanda J.] Univ Colorado, Sch Med, Dept Psychiat, Aurora, CO 80045 USA.
   [Law, Amanda J.] Univ Colorado, Sch Med, Dept Cell & Dev Biol, Aurora, CO USA.
RP Law, AJ (reprint author), Univ Colorado, Sch Med, Dept Psychiat, Aurora, CO 80045 USA.
EM amanda.law@ucdenver.edu
FU National Institute of Mental Health; Brain Behavior Research
   Foundations, Sidney R. Baer Jr. Award for Schizophrenia Research
FX This work was supported by funds from the Intramural Research Program,
   National Institute of Mental Health, and from the Brain Behavior
   Research Foundations, Sidney R. Baer Jr. Award for Schizophrenia
   Research, awarded to Amanda J. Law at the University of Colorado,
   Denver, School of Medicine. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Abe Y, 1998, J BIOL CHEM, V273, P11150, DOI 10.1074/jbc.273.18.11150
   Abe Y, 2011, J NEUROSCI, V31, P5699, DOI 10.1523/JNEUROSCI.3477-10.2011
   Assimacopoulos S, 2003, J NEUROSCI, V23, P6399
   Balciuniene J, 2007, AM J HUM GENET, V80, P938, DOI 10.1086/513607
   Barker GRI, 2007, J NEUROSCI, V27, P2948, DOI 10.1523/JNEUROSCI.5289-06.2007
   Barker GRI, 2011, J NEUROSCI, V31, P10721, DOI 10.1523/JNEUROSCI.6413-10.2011
   Bortolato M, 2013, NEUROPHARMACOLOGY, V75, P223, DOI 10.1016/j.neuropharm.2013.07.003
   Brasnjevic I, 2009, PROG NEUROBIOL, V87, P212, DOI 10.1016/j.pneurobio.2008.12.002
   Carlsson T, 2011, J NEUROCHEM, V117, P1066, DOI 10.1111/j.1471-4159.2011.07284.x
   Carteron C, 2006, J CELL SCI, V119, P898, DOI 10.1242/jcs.02799
   Chen PL, 2009, AM J HUM GENET, V84, P21, DOI 10.1016/j.ajhg.2008.12.005
   Chen YJJ, 2008, J NEUROSCI, V28, P6872, DOI 10.1523/JNEUROSCI.1815-08.2008
   Deakin IH, 2012, CEREB CORTEX, V22, P1520, DOI 10.1093/cercor/bhr223
   Deakin IH, 2009, NEUROREPORT, V20, P1523, DOI 10.1097/WNR.0b013e328330f6e7
   Dean B, 2008, SCHIZOPHR RES, V99, P341, DOI 10.1016/j.schres.2007.10.013
   del Pino I, 2013, NEURON, V79, P1152, DOI 10.1016/j.neuron.2013.07.010
   Duffy L, 2010, NEUROSCIENCE, V170, P800, DOI 10.1016/j.neuroscience.2010.07.042
   Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
   Fallin MD, 2003, AM J HUM GENET, V73, P601, DOI 10.1086/378158
   Falls DL, 2003, EXP CELL RES, V284, P14, DOI 10.1016/S0014-4827(02)00102-7
   Faraone SV, 2006, AM J PSYCHIAT, V163, P1760, DOI 10.1176/appi.ajp.163.10.1760
   Futamura T, 2003, MOL PSYCHIATR, V8, P19, DOI 10.1038/sj.mp.4001138
   Grant E, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00053
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   Hatzimanolis A, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.33
   Henck JW, 2001, TOXICOL SCI, V62, P80, DOI 10.1093/toxsci/62.1.80
   Hobbs SS, 2002, ONCOGENE, V21, P8442, DOI 10.1038/sj.onc.1205960
   Kao WT, 2010, P NATL ACAD SCI USA, V107, P15619, DOI 10.1073/pnas.1005410107
   Kastin AJ, 2004, J NEUROCHEM, V88, P965
   Kato T, 2011, MOL PSYCHIATR, V16, P307, DOI 10.1038/mp.2010.10
   Law AJ, 2012, P NATL ACAD SCI USA, V109, P12165, DOI 10.1073/pnas.1206118109
   LIPSKA BK, 1993, NEUROPSYCHOPHARMACOL, V9, P67
   Longart M, 2004, J COMP NEUROL, V472, P156, DOI 10.1002/cne.20016
   Loos M, 2014, BIOL PSYCHIAT
   Mahar I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026610
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Mefford HC, 2009, GENOME RES, V19, P1579, DOI 10.1101/gr.094987.109
   Meier S, 2013, INT J NEUROPSYCHOPH, V16, P549, DOI 10.1017/S1461145712000697
   Mizuno M, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.29
   Morar B, 2011, MOL PSYCHIATR, V16, P860, DOI 10.1038/mp.2010.70
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Ogiso H, 2002, CELL, V110, P775, DOI 10.1016/S0092-8674(02)00963-7
   Papaleo F, 2008, J NEUROSCI, V28, P8709, DOI 10.1523/JNEUROSCI.2077-08.2008
   Portera-Cailliau C, 2005, PLOS BIOL, V3, P1473, DOI 10.1371/journal.pbio.0030272
   Sanchez MM, 2001, DEV PSYCHOPATHOL, V13, P419, DOI 10.1017/S0954579401003029
   Saunders RC, 1998, NATURE, V393, P169, DOI 10.1038/30245
   Shamir A, 2012, J NEUROSCI, V32, P2988, DOI 10.1523/JNEUROSCI.1899-11.2012
   Tost H, 2014, J NEUROSCI, V34, P1051, DOI 10.1523/JNEUROSCI.3496-13.2014
   Turner JR, 2013, MOL PSYCHIAT
   Vullhorst D, 2009, J NEUROSCI, V29, P12255, DOI 10.1523/JNEUROSCI.2454-09.2009
   Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
   Wang YC, 2008, BIOL PSYCHIAT, V64, P1093, DOI 10.1016/j.biopsych.2008.07.012
   Yin DM, 2013, NEURON, V78, P644, DOI 10.1016/j.neuron.2013.03.028
   Zhang DX, 1997, P NATL ACAD SCI USA, V94, P9562, DOI 10.1073/pnas.94.18.9562
NR 54
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 5
PY 2014
VL 9
IS 8
AR e104172
DI 10.1371/journal.pone.0104172
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO5BW
UT WOS:000341357200084
PM 25093331
ER

PT J
AU Hellendoorn, A
AF Hellendoorn, Annika
TI Understanding social engagement in autism: being different in perceiving
   and sharing affordances
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE social cognition; theory of mind; embodied cognition; affordances;
   autism spectrum disorder
ID BIOLOGICAL MOTION; YOUNG-CHILDREN; PERCEPTION; FACE; MIND; INDIVIDUALS;
   RECOGNITION; DISORDER; SKILLS; SIGNS
AB In the current paper I will argue that the notion of affordances offers an alternative to theory of mind (ToM) approaches in studying social engagement in general and in explaining social engagement in autism spectrum disorder (ASD) specifically. Affordances are the possibilities for action offered by the environment. In contrast to ToM approaches, the concept of affordances implies the complementarity of person and environment and rejects the dualism of mind and behavior. In line with the Gibsonian idea that a child must eventually perceive the affordances of the environment for others as well for herself in order to become socialized, I will hypothesize that individuals with ASD often do not perceive the same affordances in the environment as other people do and have difficulties perceiving others' affordances. This can lead to a disruption of interpersonal behaviors. I will further argue that the methods for studying social engagement should be adapted if we want to take interaction into account.
C1 Univ Utrecht, Ctr Cognit & Motor Disabil, Dept Special Educ, NL-3508 TC Utrecht, Netherlands.
RP Hellendoorn, A (reprint author), Univ Utrecht, Ctr Cognit & Motor Disabil, Dept Special Educ, Heidelberglaan 1,POB 80-140, NL-3508 TC Utrecht, Netherlands.
EM A.Hellendoorn@uu.nl
CR ADOLPH KE, 1993, CHILD DEV, V64, P1158, DOI 10.1111/j.1467-8624.1993.tb04193.x
   Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
   Barrett L, 2011, BRAIN BODY ENV SHAPE
   Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
   BRACHA HS, 1995, J NEUROPSYCH CLIN N, V7, P213
   Charness N, 2001, MEM COGNITION, V29, P1146, DOI 10.3758/BF03206384
   De Jaegher H., 2007, PHENOMENOLOGY COGNIT, V6, P485, DOI [DOI 10.1007/S11097-007-9076-9, 10.1007/s11097-007-9076-9]
   De Jaegher H., 2006, SOCIAL INTERACTION R
   De Jaegher Hanne, 2013, Front Integr Neurosci, V7, P15, DOI 10.3389/fnint.2013.00015
   Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
   Donnellan M, 2013, FRONT INTEGR NEUROSC, V6, P124, DOI [10.3389/fnint.2012.00124, DOI 10.3389/FNINT.2012.00124]
   Dreyfus HL, 2006, TOPOI-INT REV PHILOS, V25, P43, DOI 10.1007/s11245-006-0006-1
   Fuchs T, 2009, PHENOMENOL COGN SCI, V8, P465, DOI 10.1007/s11097-009-9136-4
   Gallagher S., 2004, PHILOS PSYCHIAT PSYC, V11, P199, DOI [10.1353/ppp.2004.0063, DOI 10.1353/PPP.2004.0063]
   Gallagher S, 2001, J CONSCIOUSNESS STUD, V8, P83
   Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006
   Gibson E. J., 2000, PERCEPTUAL LEARNING
   Gibson J. J., 1986, ECOLOGICAL APPROACH
   Goffaux V, 2006, J EXP PSYCHOL HUMAN, V32, P1023, DOI 10.1037/0096-1523.32.4.1023
   Good JMM, 2007, THEOR PSYCHOL, V17, P265, DOI 10.1177/0959354307075046
   Hellendoorn A, 2014, RES DEV DISABIL, V35, P423, DOI 10.1016/j.ridd.2013.11.012
   JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378
   Jordan H, 2002, PSYCHOL SCI, V13, P162, DOI 10.1111/1467-9280.00429
   Kapp Steven K, 2013, Front Integr Neurosci, V7, P38, DOI 10.3389/fnint.2013.00038
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Leudar I., 2009, THEORY MIND, P1
   LOVELAND K A, 1991, Ecological Psychology, V3, P99, DOI 10.1207/s15326969eco0302_3
   Loveland KA, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P17
   MCARTHUR LZ, 1983, PSYCHOL REV, V90, P215, DOI 10.1037//0033-295X.90.3.215
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Nackaerts E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044473
   OZONOFF S, 1995, J AUTISM DEV DISORD, V25, P415, DOI 10.1007/BF02179376
   Pellicano E, 2006, DEVELOPMENTAL SCI, V9, P270, DOI 10.1111/j.1467-7687.2006.00489.x
   Premack D., 1978, BEHAVIORAL BRAIN SCI, V4, P515, DOI [10.1017/S0140525X00076512, DOI 10.1017/S0140525X00076512]
   Reddy V., 2008, INFANTS KNOW MINDS
   Tanaka JW, 1998, VIS COGN, V5, P479
   Thelen E., 2008, DEV PERSPECTIVES EMB, P99
   Trevarthen C, 2005, BRAIN DEV-JPN, V27, pS25, DOI 10.1016/j.braindev.2005.03.016
   Van Overwalle F, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00560
   Vlamings PHJM, 2010, BIOL PSYCHIAT, V68, P1107, DOI 10.1016/j.biopsych.2010.06.024
   Weisberg J, 2014, CEREB CORTEX, V24, P37, DOI 10.1093/cercor/bhs276
   Williams D., 1999, COLOUR BLIND SOUL SE
   Williams E, 2004, THEOR PSYCHOL, V14, P704, DOI 10.1177/0959354304046180
   Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
NR 48
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD AUG 4
PY 2014
VL 5
AR 850
DI 10.3389/fpsyg.2014.00850
PG 5
WC Psychology, Multidisciplinary
SC Psychology
GA AN6LJ
UT WOS:000340705700001
PM 25136327
ER

PT J
AU Hill, DA
   Flores, MM
   Kearley, RF
AF Hill, Doris Adams
   Flores, Margaret M.
   Kearley, Regina F.
TI Maximizing ESY Services: Teaching Pre-Service Teachers to Assess
   Communication Skills and Implement Picture Exchange With Students With
   Autism Spectrum Disorder and Developmental Disabilities
SO TEACHER EDUCATION AND SPECIAL EDUCATION
LA English
DT Article
DE PECS (TM); autism spectrum disorder; communication; pre-service
   teachers; ESY Services
ID SYSTEM PECS; SPEECH DEVELOPMENT; CHILDREN; METAANALYSIS; INDIVIDUALS
AB The authors supervised and trained pre-service teachers while conducting extended school year (ESY) services for pre-kindergarten and elementary students with autism spectrum disorder (ASD) and other developmental disabilities (DD). Each classroom was responsible for conducting communication assessments and developing interventions focused on increasing functional communication. One intervention, the Picture Exchange Communication System (PECS (TM)), was taught to three pre-service teachers and staff who implemented PECS (TM) with four students who lacked functional communication skills. The teachers were mentored as they implemented the appropriate level of PECS (TM) and developed communication books for the students to use in school, home, and other settings.
C1 [Hill, Doris Adams] Auburn Univ, Dept Special Educ Rehabil & Counseling, Educ & Community Supports, Auburn, AL 36849 USA.
   [Flores, Margaret M.] Auburn Univ, Dept Special Educ Rehabil & Counseling, Special Educ, Auburn, AL 36849 USA.
   [Kearley, Regina F.] Auburn Univ, Special Edcuat, Auburn, AL 36849 USA.
RP Hill, DA (reprint author), Auburn Univ, Dept Special Educ Rehabil & Counseling, 215 South Donahue Dr, Auburn, AL 36849 USA.
EM hilldol@auburn.edu
CR Arthur-Kelly M, 2009, DISABIL REHABIL, V31, P1474, DOI 10.1080/09638280802590629
   Bondy A, 2012, PSYCHOL REC, V62, P789
   Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
   Canella-Malone H., 2010, J PHYS DISABILITIES, V22, P149
   Carr D, 2007, J AUTISM DEV DISORD, V37, P724, DOI 10.1007/s10803-006-0203-1
   Carr D., 2007, J AUTISM DEV DISORD, V37, P280
   Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213
   Flippin M, 2010, AM J SPEECH-LANG PAT, V19, P178, DOI 10.1044/1058-0360(2010/09-0022)
   Frost L., 2002, PICTURE EXCHANGE COM, V2nd
   Ganz JB, 2004, J AUTISM DEV DISORD, V34, P395, DOI 10.1023/B:JADD.0000037416.59095.d7
   Ganz JB, 2009, AUGMENT ALTERN COMM, V25, P250, DOI 10.3109/07434610903381111
   Hammill D. D., 2008, TEST LANGUAGE DEV PR, V4th
   Hammill D. D., 2008, TEST LANGUAGE DEV IN, V4<SUP>th</SUP>
   Hart SL, 2010, REM SPEC EDUC, V31, P476, DOI 10.1177/0741932509338354
   Heflin L., 2007, STUDENTS AUTISM SPEC, V2nd
   Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
   Johnston S., 2003, AUGMENTATIVE ALTERNA, V19, P86, DOI 10.1080/0743461031000112016
   Kravits TR, 2002, J AUTISM DEV DISORD, V32, P225, DOI 10.1023/A:1015457931788
   Magiati I, 2003, AUTISM, V7, P297, DOI 10.1177/1362361303007003006
   Marckel JM, 2006, J APPL BEHAV ANAL, V39, P109, DOI 10.1901/jaba.2006.131-04
   Mesibov G. B., 1997, AUTISM UNDERSTANDING
   National Autism Center, 2009, EV BAS PRACT AUT SCH
   Ostryn C, 2008, RES PRACT PERS SEV D, V33, P13
   Pasco G, 2011, INT J LANG COMM DIS, V46, P120, DOI 10.3109/13682822.2010.484851
   Ryan J., 2011, TEACHING EXCEPTIONAL, V43, P56
   Tincani M, 2006, EDUC TRAIN DEV DISAB, V41, P177
   Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
   Yell M., 2012, LAW SPECIAL ED
   Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
NR 29
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0888-4064
EI 1944-4931
J9 TEACH EDUC SPEC EDUC
JI Teach. Educ. Spec. Educ.
PD AUG
PY 2014
VL 37
IS 3
BP 241
EP 254
DI 10.1177/0888406414527117
PG 14
WC Education & Educational Research
SC Education & Educational Research
GA CI3MM
UT WOS:000354651900004
ER

PT J
AU Bernardi, RE
   Spanagel, R
AF Bernardi, Rick E.
   Spanagel, Rainer
TI Enhanced Extinction of Contextual Fear Conditioning in Clock Delta 19
   Mutant Mice
SO BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE circadian; clock; Clock Delta 19 mutant mice; contextual fear
   conditioning; dopamine; extinction; modafinil
ID PLACE PREFERENCE; CIRCADIAN CLOCK; DOPAMINE; COCAINE; RECEPTOR; GENE;
   ACQUISITION; BEHAVIORS; MODAFINIL; MUTATION
AB Clock genes have been implicated in several disorders, such as schizophrenia, bipolar disorder, autism spectrum disorders, and drug dependence. However, few studies to date have examined the role of clock genes in fear-related behaviors. The authors used mice with the Clock Delta 19 mutation to assess the involvement of this gene in contextual fear conditioning. Male wild-type (WT) and Clock Delta 19 mutant mice underwent a single session of contextual fear conditioning (12 min, 4 unsignaled shocks), followed by daily 12-min retention trials. There were no differences between mutant and WT mice in the acquisition of contextual fear, and WT and mutant mice demonstrated similar freezing during the first retention session. However, extinction of contextual fear was accelerated in mutant mice across the remaining retention sessions, as compared to WT mice, suggesting a role for Clock in extinction following aversive learning. Because the Clock Delta 19 mutation has previously been demonstrated to result in an increase in dopamine signaling, the authors confirmed the role of dopamine in extinction learning using preretention session administration of a low dose of the dopamine transport reuptake inhibitor modafinil (0.75 mg/kg), which resulted in decreased freezing across retention sessions. These findings are consistent with an emerging portrayal of the importance of Clock genes in noncircadian functions, as well as the important role of dopamine in extinction learning.
C1 [Bernardi, Rick E.; Spanagel, Rainer] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Inst Psychopharmacol, Mannheim, Germany.
RP Bernardi, RE (reprint author), Cent Inst Mental Hlth, Inst Psychopharmacol, J5, D-68159 Mannheim, Germany.
EM rick.bernardi@zi-mannheim.de
FU Deutsche Forschungsgemeinschaft (DFG) [SPP1226, SP 383/4-1]
FX Rick E. Bernardi was supported by a grant from the Deutsche
   Forschungsgemeinschaft (DFG, SPP1226, SP 383/4-1). We report no
   conflicts of interest.
CR Abraham AD, 2014, NEUROBIOL LEARN MEM, V108, P65, DOI 10.1016/j.nlm.2013.11.007
   Abraham AD, 2012, LEARN MEMORY, V19, P67, DOI 10.1101/lm.024752.111
   Albrecht U., 2013, HDB EXP PHARM, V217, P227, DOI DOI 10.1007/978-3-642-25950-0_
   Bernardi RE, 2013, DRUG ALCOHOL DEPEN, V133, P733, DOI 10.1016/j.drugalcdep.2013.08.024
   Bernardi RE, 2010, BEHAV NEUROSCI, V124, P204, DOI 10.1037/a0018909
   DEBUNDEL D, 2013, FRONT BEHAV NEUROSCI, V7, DOI DOI 10.3389/FNBEH.2013
   Dibner C, 2010, ANNU REV PHYSIOL, V72, P517, DOI 10.1146/annurev-physiol-021909-135821
   El-Ghundi M, 2001, BRAIN RES, V892, P86, DOI 10.1016/S0006-8993(00)03234-0
   Fernandez Espejo Emilio, 2003, Neuropsychopharmacology, V28, P490
   Garcia JA, 2000, SCIENCE, V288, P2226, DOI 10.1126/science.288.5474.2226
   Guarraci FA, 1999, BRAIN RES, V827, P28, DOI 10.1016/S0006-8993(99)01291-3
   Harley Carolyn W., 2004, Neural Plasticity, V11, P191, DOI 10.1155/NP.2004.191
   Inoue T, 2000, PHARMACOL BIOCHEM BE, V66, P573, DOI 10.1016/S0091-3057(00)00254-9
   King DP, 1997, CELL, V89, P641, DOI 10.1016/S0092-8674(00)80245-7
   Ko CH, 2006, HUM MOL GENET, V15, pR271, DOI 10.1093/hmg/ddl207
   Lattal KM, 2012, BEHAV PROCESS, V90, P49, DOI 10.1016/j.beproc.2012.03.008
   McClung CA, 2005, P NATL ACAD SCI USA, V102, P9377, DOI 10.1073/pnas.0503584102
   Ozburn AR, 2012, PSYCHOPHARMACOLOGY, V223, P169, DOI 10.1007/s00213-012-2704-2
   Ozburn AR, 2013, NEUROPSYCHOPHARMACOL, V38, P2393, DOI 10.1038/npp.2013.138
   Perreau-Lenz S, 2008, DRUG NEWS PERSPECT, V21, P211, DOI 10.1358/dnp.2008.21.4.1213350
   Rosenwasser AM, 2010, NEUROSCI BIOBEHAV R, V34, P1249, DOI 10.1016/j.neubiorev.2010.03.004
   Shuman T, 2012, BEHAV BRAIN RES, V235, P105, DOI 10.1016/j.bbr.2012.07.039
   Shuman T, 2009, BEHAV NEUROSCI, V123, P257, DOI 10.1037/a0014366
   Spencer S, 2012, J NEUROCHEM, V123, P124, DOI 10.1111/j.1471-4159.2012.07857.x
   VITATERNA MH, 1994, SCIENCE, V264, P719, DOI 10.1126/science.8171325
   Wang LMC, 2009, ASN NEURO, V1, DOI 10.1042/AN20090020
   Zueger M, 2006, J NEURAL TRANSM, V113, P347, DOI 10.1007/s00702-005-0322-4
NR 27
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0735-7044
EI 1939-0084
J9 BEHAV NEUROSCI
JI Behav. Neurosci.
PD AUG
PY 2014
VL 128
IS 4
BP 468
EP 473
DI 10.1037/a0037020
PG 6
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CA8KQ
UT WOS:000349169300006
PM 24865659
ER

PT J
AU Bone, D
   Lee, CC
   Black, MP
   Williams, ME
   Lee, S
   Levitt, P
   Narayanan, S
AF Bone, Daniel
   Lee, Chi-Chun
   Black, Matthew P.
   Williams, Marian E.
   Lee, Sungbok
   Levitt, Pat
   Narayanan, Shrikanth
TI The Psychologist as an Interlocutor in Autism Spectrum Disorder
   Assessment: Insights From a Study of Spontaneous Prosody
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Article
DE autism spectrum disorder; children; prosody; social communication;
   assessment; dyadic interaction
ID HIGH-FUNCTIONING AUTISM; CLASSIFICATION-SYSTEM SDCS; BREATHY VOCAL
   QUALITY; CHILDREN; SPEECH; COMMUNICATION; LANGUAGE; EMOTION; EXTENSIONS;
   ENGAGEMENT
AB Purpose: The purpose of this study was to examine relationships between prosodic speech cues and autism spectrum disorder (ASD) severity, hypothesizing a mutually interactive relationship between the speech characteristics of the psychologist and the child. The authors objectively quantified acoustic-prosodic cues of the psychologist and of the child with ASD during spontaneous interaction, establishing a methodology for future large-sample analysis.
   Method: Speech acoustic-prosodic features were semiautomatically derived from segments of semistructured interviews (Autism Diagnostic Observation Schedule, ADOS; Lord, Rutter, DiLavore, & Risi, 1999; Lord et al., 2012) with 28 children who had previously been diagnosed with ASD. Prosody was quantified in terms of intonation, volume, rate, and voice quality. Research hypotheses were tested via correlation as well as hierarchical and predictive regression between ADOS severity and prosodic cues.
   Results: Automatically extracted speech features demonstrated prosodic characteristics of dyadic interactions. As rated ASD severity increased, both the psychologist and the child demonstrated effects for turn-end pitch slope, and both spoke with atypical voice quality. The psychologist's acoustic cues predicted the child's symptom severity better than did the child's acoustic cues.
   Conclusion: The psychologist, acting as evaluator and interlocutor, was shown to adjust his or her behavior in predictable ways based on the child's social-communicative impairments. The results support future study of speech prosody of both interaction partners during spontaneous conversation, while using automatic computational methods that allow for scalable analysis on much larger corpora.
C1 [Bone, Daniel; Lee, Chi-Chun; Black, Matthew P.; Lee, Sungbok; Narayanan, Shrikanth] Univ So Calif, SAIL, Los Angeles, CA 90095 USA.
   [Williams, Marian E.] Univ So Calif, Keck Sch Med, Univ Ctr Excellence Dev Disabil, Los Angeles, CA 90033 USA.
   [Williams, Marian E.; Levitt, Pat] Childrens Hosp Los Angeles, Los Angeles, CA USA.
   [Levitt, Pat] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
RP Bone, D (reprint author), Univ So Calif, SAIL, Los Angeles, CA 90095 USA.
EM dbone@usc.edu
FU National Science Foundation; National Institutes of Health [PL-R21
   HD065289]
FX This research was supported by funds from the National Science
   Foundation and by National Institutes of Health Grant PL-R21 HD065289.
   We are grateful to Sylvia Acosta and Irina Zamora for their
   administration of the ADOS and to Marcia Higareda for her recruiting
   efforts.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Speech-Language-Hearing Association, 2007, CHILDH APR SPEECH
   American Speech-Language-Hearing Association, 2007, TECHNICAL REPORT
   BACHOROWSKI JA, 1995, PSYCHOL SCI, V6, P219, DOI 10.1111/j.1467-9280.1995.tb00596.x
   Baltaxe C., 1984, P 10 INT C PHON SCI, P713
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Black M. P., 2011, P INT 2011, V2011, P1497
   Boersma P., 2001, GLOT INT, V5, P341
   Bone D., 2013, P INT 2013, V2013, P2400
   Bone D., 2012, P INT 2012, V2012, P1043
   Bone D., 2012, P INT 2012, V2012, P1175
   Boucher M. J., 2011, AM SPEECH LANG HEAR
   Busso C, 2009, IEEE T AUDIO SPEECH, V17, P582, DOI 10.1109/TASL.2008.2009578
   Cruttenden Alan, 1997, INTONATION, V2nd
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Diehl JJ, 2009, APPL PSYCHOLINGUIST, V30, P385, DOI 10.1017/S0142716409090201
   Eyben F., 2010, P ACM MULT MM FLOR I, P1459, DOI 10.1145/1873951.1874246
   Frith U, 2005, CURR BIOL, V15, pR786, DOI 10.1016/j.cub.2005.09.033
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   FURROW D, 1984, J CHILD LANG, V11, P203
   Garcia-Perez RM, 2007, J AUTISM DEV DISORD, V37, P1310, DOI 10.1007/s10803-006-0276-x
   Gelfer M. P., 1988, J VOICE, V2, P320, DOI 10.1016/S0892-1997(88)80024-9
   Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Halberstam B, 2004, ORL J OTO-RHINO-LARY, V66, P70, DOI 10.1159/000077798
   Heman-Ackah YD, 2003, ANN OTO RHINOL LARYN, V112, P324
   HILLENBRAND J, 1994, J SPEECH HEAR RES, V37, P769
   Hillenbrand J, 1996, J SPEECH HEAR RES, V39, P311
   Jones CD, 2009, J AUTISM DEV DISORD, V39, P432, DOI 10.1007/s10803-008-0642-y
   Juslin P. N., 2005, NEW HDB METHODS NONV, P65
   Katsamanis A., 2011, WORKSH NEW TOOLS MET
   Kimura M, 2006, J NONVERBAL BEHAV, V30, P115, DOI 10.1007/s10919-006-0011-5
   Knapp M. L., 2009, NONVERBAL COMMUNICAT
   KREIMAN J, 1993, J SPEECH HEAR RES, V36, P21
   Lee CC, 2014, COMPUT SPEECH LANG, V28, P518, DOI 10.1016/j.csl.2012.06.006
   Lee C.-C., 2012, P INT 2012, V2012, P619
   Li X, 2007, INT CONF ACOUST SPEE, P1081, DOI 10.1109/ICMLC.2007.4370304
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2012, J CHILD PSYCHOL PSYC, V53, P490, DOI 10.1111/j.1469-7610.2012.02547.x
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   McAllister A., 1998, LOGOP PHONIATR VOCO, V23, P27
   McCann J, 2003, INT J LANG COMM DIS, V38, P325, DOI 10.1080/1368282031000154204
   Miller J., 2008, SYSTEMATIC ANAL LANG
   Narayanan S, 2013, P IEEE, V101, P1203, DOI 10.1109/JPROC.2012.2236291
   PACCIA JM, 1982, J SPEECH HEAR RES, V25, P42
   PAUL DB, 1992, P WORKSH SPEECH NAT, P357, DOI 10.3115/1075527.1075614
   Paul R, 2005, J AUTISM DEV DISORD, V35, P861, DOI 10.1007/s10803-005-0031-8
   Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
   Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
   Peppe S., 2011, SPEECH PROSODY ATYPI, P1
   Ploog BO, 2009, RES AUTISM SPECT DIS, V3, P743, DOI 10.1016/j.rasd.2009.02.004
   Prizant BM, 2003, INFANT YOUNG CHILD, V16, P296
   PRONOVOST W, 1966, EXCEPT CHILDREN, V33, P19
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155
   Shobaki K., 2000, P ICSLP2000 OCT, V4, P258
   Shriberg LD, 2011, J AUTISM DEV DISORD, V41, P405, DOI 10.1007/s10803-010-1117-5
   Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
   Shriberg LD, 2010, CLIN LINGUIST PHONET, V24, P795, DOI 10.3109/02699206.2010.503006
   Shriberg LD, 1997, J SPEECH LANG HEAR R, V40, P723
   Shue Y. L., 2010, ENERGY, V1, pH1
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   Sonmez M. K., 1997, 5 EUR C SPEECH COMM
   ULDALL E, 1960, LANG SPEECH, V3, P223
   Van Santen J, 2010, AUTISM, V14, P215, DOI 10.1177/1362361309363281
   Vernon TW, 2012, J AUTISM DEV DISORD, V42, P2702, DOI 10.1007/s10803-012-1535-7
   Weider S., 2003, AUTISM, V7, P425
   Wells B, 1998, LANG SPEECH, V41, P265
   Young S. J., 1993, 153 CAMBR U DEP ENG
NR 70
TC 0
Z9 0
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
EI 1558-9102
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD AUG
PY 2014
VL 57
IS 4
BP 1162
EP 1177
DI 10.1044/2014_JSLHR-S-13-0062
PG 16
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AZ4NF
UT WOS:000348198000003
PM 24686340
ER

PT J
AU Whitehouse, AJO
   Shelton, WMR
   Ing, C
   Newnham, JP
AF Whitehouse, Andrew J. O.
   Shelton, W. M. R.
   Ing, Caleb
   Newnham, John P.
TI Prenatal, Perinatal, and Neonatal Risk Factors for Specific Language
   Impairment: A Prospective Pregnancy Cohort Study
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Article
DE specific language impairment; prenatal; obstetric
ID OBSTETRIC COMPLICATIONS; FOLLOW-UP; AUTISM; CHILDREN; DISORDERS;
   OUTCOMES; ATTRITION
AB Purpose: Although genetic factors are known to play a causal role in specific language impairment (SLI), environmental factors may also be important. This study examined whether there are prenatal, perinatal, and neonatal factors that are associated with childhood SLI.
   Method: Participants were members of the Raine Study, a prospective cohort investigation of pregnant women and their offspring. Parent report indicated that 26 children had received a clinical diagnosis of SLI. Data from antenatal and birth medical records were compared between the children with SLI and typically developing comparison children (N = 1,799).
   Results: There were no statistically significant differences between the SLI and comparison groups in the individual prenatal, perinatal, and neonatal factors examined. Aggregate risk scores were calculated for each period on the basis of factors known to be associated with neurodevelopmental disorder. There were no group differences in aggregate risk scores in the prenatal and perinatal periods. However, significantly more children in the SLI group (50%) compared with the comparison group (27.6%) experienced 2 or more risk factors during the neonatal period.
   Conclusion: The vast majority of prenatal, perinatal, and neonatal complications do not play a clear causal role in childhood SLI. However, poor neonatal health may signify increased risk for SLI.
C1 [Whitehouse, Andrew J. O.; Shelton, W. M. R.] Univ Western Australia, Telethon Kids Inst, Perth, WA 6009, Australia.
   [Ing, Caleb] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA.
   [Newnham, John P.] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia.
RP Whitehouse, AJO (reprint author), Univ Western Australia, Telethon Kids Inst, Perth, WA 6009, Australia.
EM awhitehouse@ichr.uwa.edu.au
FU National Health and Medical Research Council (NHMRC); University of
   Western Australia (UWA); Curtin University; UWA Faculty of Medicine,
   Dentistry and Health Sciences; Raine Medical Research Foundation;
   Telethon Institute for Child Health Research; Women and Infants Research
   Foundation; NHMRC [1004065, 1003424]
FX The authors would like to acknowledge the National Health and Medical
   Research Council (NHMRC) for its long-term contribution to funding the
   study over the last 20 years. Core Management of the Raine Study has
   been funded by the University of Western Australia (UWA); Curtin
   University; the UWA Faculty of Medicine, Dentistry and Health Sciences;
   the Raine Medical Research Foundation; the Telethon Institute for Child
   Health Research; and the Women and Infants Research Foundation. Andrew
   J. O. Whitehouse is funded by a Career Development Fellowship from the
   NHMRC (No. 1004065). This study was partly funded by NHMRC Project Grant
   No. 1003424. These funders had no further role in study design,
   analysis, data interpretation, or manuscript writing and submission. The
   authors are extremely grateful to all of the families who took part in
   this study and the whole Raine Study team, which includes the cohort
   manager, data manager, and data collection team.
CR Albers LL, 1996, OBSTET GYNECOL, V87, P355, DOI 10.1016/0029-7844(95)00423-8
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   [Anonymous], 1992, INT STAT CLASS DIS R
   Bhutta AT, 2002, JAMA-J AM MED ASSOC, V288, P728, DOI 10.1001/jama.288.6.728
   Bishop DVM, 1997, BRAIN LANG, V56, P1, DOI 10.1006/brln.1997.1729
   Bishop DVM, 2008, GENES BRAIN BEHAV, V7, P365, DOI 10.1111/j.1601-183X.2007.00360.x
   Blair Eve M, 2005, BMC Pediatr, V5, P13, DOI 10.1186/1471-2431-5-13
   BRICKER D, 1988, J PEDIATR PSYCHOL, V13, P55, DOI 10.1093/jpepsy/13.1.55
   Buka SL, 2004, SCHIZOPHR RES, V71, P417, DOI 10.1016/j.schres.2004.04.004
   Cannon M, 2002, AM J PSYCHIAT, V159, P1080, DOI 10.1176/appi.ajp.159.7.1080
   Conti-Ramsden G, 2001, INT J LANG COMM DIS, V36, P207, DOI 10.1080/13682820010019883
   de Graaf R, 2000, AM J EPIDEMIOL, V152, P1039
   Dunn L. M., 1981, PEABODY PICTURE VOCA
   Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
   GOODMAN R, 1990, J CHILD PSYCHOL PSYC, V31, P809, DOI 10.1111/j.1469-7610.1990.tb00820.x
   Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
   Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
   Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x
   Merricks MJ, 2004, J NEURAL TRANSM, V111, P773, DOI 10.1007/s00702-003-0051-5
   NEWNHAM JP, 1993, LANCET, V342, P887
   Practice Management Information Corporation, 1993, INT CLASS DIS
   Rao A, 2004, BEST PRACT RES CL OB, V18, P557, DOI 10.1016/j.bpobgyn.2004.04.007
   Raven J., 1977, RAVENS COLOURED PROG
   Robinson M, 2013, J DEV ORIG HLTH DIS, V4, P42, DOI 10.1017/S2040174412000578
   Rothman K J, 1990, Epidemiology, V1, P43, DOI 10.1097/00001648-199001000-00010
   Semel E, 1995, CLIN EVALUATION LANG, V3rd
   Stanton-Chapman TL, 2004, TOP EARLY CHILD SPEC, V24, P227, DOI 10.1177/02711214040240040401
   Stothard SE, 1998, J SPEECH LANG HEAR R, V41, P407
   Tomblin JB, 1997, J COMMUN DISORD, V30, P325, DOI 10.1016/S0021-9924(97)00015-4
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   Whitehouse AJO, 2010, EARLY HUM DEV, V86, P487, DOI 10.1016/j.earlhumdev.2010.06.009
   Whitehouse AJO, 2009, INT J LANG COMM DIS, V44, P511, DOI 10.1080/13682820802708098
   Whitehouse AJO, 2012, PEDIATRICS, V129, P485, DOI 10.1542/peds.2011-2644
   Whitehouse AJO, 2007, J CHILD PSYCHOL PSYC, V48, P822, DOI 10.1111/j.1469-7610.2007.01765.x
   Whitehouse AJO, 2012, J CHILD PSYCHOL PSYC, V53, P726, DOI 10.1111/j.1469-7610.2011.02523.x
   Whitehouse AJO, 2009, INT J LANG COMM DIS, V44, P489, DOI 10.1080/13682820802708080
   Wolke D, 2009, BRIT J PSYCHIAT, V195, P249, DOI 10.1192/bjp.bp.108.053751
   World Health Organization, 2004, OB PREV MAN GLOB EP
   Young AF, 2006, AUST NZ J PUBL HEAL, V30, P353, DOI 10.1111/j.1467-842X.2006.tb00849.x
NR 39
TC 0
Z9 0
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
EI 1558-9102
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD AUG
PY 2014
VL 57
IS 4
BP 1418
EP 1427
DI 10.1044/2014_JSLHR-L-13-0186
PG 10
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AZ4NF
UT WOS:000348198000023
PM 24686440
ER

PT J
AU Kover, ST
   Weismer, SE
AF Kover, Sara T.
   Weismer, Susan Ellis
TI Lexical Characteristics of Expressive Vocabulary in Toddlers With Autism
   Spectrum Disorder
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Article
DE autism; statistical learning; vocabulary; language development;
   production
ID LATE-TALKING TODDLERS; COMMUNICATIVE DEVELOPMENT; SIMILARITY
   NEIGHBORHOODS; PHONOTACTIC PROBABILITY; LANGUAGE-ACQUISITION; COGNITIVE
   SKILLS; WORKING-MEMORY; YOUNG-CHILDREN; INFANTS; PRESCHOOLERS
AB Purpose: Vocabulary is a domain of particular challenge for many children with autism spectrum disorder (ASD). Recent research has drawn attention to ways in which lexical characteristics relate to vocabulary acquisition. The current study tested the hypothesis that lexical characteristics account for variability in vocabulary size of young children with ASD, applying the extended statistical learning theory of vocabulary delay in late talkers (Stokes, Kern, & Dos Santos, 2012) to toddlers with ASD.
   Method: Parents reported the words produced by toddlers with ASD (n = 57; age 21-37 months) or toddlers without ASD (n = 41; age 22-26 months) on the MacArthur-Bates Communicative Development Inventories. The average phonological neighborhood density, word frequency, and word length of each toddler's lexicon were calculated. These lexical characteristics served as predictors of vocabulary size.
   Results: Findings differed for toddlers with and without ASD and according to subsamples. Word length was the most consistent predictor of vocabulary size for toddlers with ASD.
   Conclusions: Distinct relationships between lexical characteristics and vocabulary size were observed for toddlers with and without ASD. Experimental studies on distributional cues to vocabulary acquisition are needed to inform what is known about mechanisms of learning in neurodevelopmental disorders.
C1 [Kover, Sara T.; Weismer, Susan Ellis] Waisman Ctr Mental Retardat & Human Dev, Madison, WI 53705 USA.
   [Kover, Sara T.; Weismer, Susan Ellis] Univ Wisconsin, Madison, WI 53706 USA.
RP Kover, ST (reprint author), Univ Washington, Seattle, WA 98195 USA.
EM skover@u.washington.edu
FU National Institutes of Health [R01 DC07223, R01 DC03731, T32 DC05359,
   P30 HD03352]
FX This research was supported by National Institutes of Health Grants R01
   DC07223, R01 DC03731, T32 DC05359 (Susan Ellis Weismer, principal
   investigator [PI]), and P30 HD03352 (Marsha Mailick, PI). We offer
   sincere appreciation to the families who participated in this study. A
   portion of these data was presented at the 2013 biennial meeting of the
   Society for Research in Child Development in Seattle, Washington.
CR Alt M, 2012, INT J LANG COMM DIS, V47, P487, DOI 10.1111/j.1460-6984.2012.00169.x
   Arciuli J., 2012, FRONT PSYCHOL, V3, P1
   Bayley N, 2006, BAYLEY SCALES INFANT, V3rd
   Boucher J., 2008, MEMORY AUTISM, P268, DOI DOI 10.1017/CBO9780511490101.016
   Brown J, 2010, Q J EXP PSYCHOL, V63, P1789, DOI 10.1080/17470210903536910
   Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
   Conway CM, 2010, COGNITION, V114, P356, DOI 10.1016/j.cognition.2009.10.009
   Eigsti IM, 2011, RES AUTISM SPECT DIS, V5, P681, DOI 10.1016/j.rasd.2010.09.001
   Estes KG, 2007, PSYCHOL SCI, V18, P254
   Estes KG, 2011, INFANCY, V16, P180, DOI 10.1111/j.1532-7078.2010.00046.x
   Evans JL, 2009, J SPEECH LANG HEAR R, V52, P321, DOI 10.1044/1092-4388(2009/07-0189)
   Fenson L, 1993, MACARTHUR COMMUNICAT
   Fenson L, 2007, MACARTHUR BATES COMM
   Frankenburg W., 1990, DENVER SCREENING TES
   Gabig CS, 2008, LANG SPEECH HEAR SER, V39, P498, DOI 10.1044/0161-1461(2008/07-0023)
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Gomez RL, 1999, COGNITION, V70, P109, DOI 10.1016/S0010-0277(99)00003-7
   Goodman JC, 2008, J CHILD LANG, V35, P515, DOI 10.1017/S0305000907008641
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gray S, 2012, J SPEECH LANG HEAR R, V55, P1289, DOI 10.1044/1092-4388(2012/11-0095)
   Hay JF, 2011, COGNITIVE PSYCHOL, V63, P93, DOI 10.1016/j.cogpsych.2011.06.002
   Hoover JR, 2010, J MEM LANG, V63, P100, DOI 10.1016/j.jml.2010.02.003
   Kidd E, 2012, DEV PSYCHOL, V48, P171, DOI 10.1037/a0025405
   Kover ST, 2013, J AUTISM DEV DISORD, V43, P2696, DOI 10.1007/s10803-013-1823-x
   Kover ST, 2013, AJIDD-AM J INTELLECT, V118, P3, DOI 10.1352/1944-7558-118.1.3
   Kucera H., 1967, COMPUTATIONAL ANAL P
   Lany J, 2011, DEVELOPMENTAL SCI, V14, P1207, DOI 10.1111/j.1467-7687.2011.01073.x
   Large N. R., 1998, 22 IND U SPEECH RES
   Leach L, 2007, COGNITIVE PSYCHOL, V55, P306, DOI 10.1016/j.cogpsych.2007.01.001
   Leonard L., 1991, LANG SPEECH HEAR SER, V22, P66
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094
   Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z
   Mayo J, 2012, J AUTISM DEV DISORD, V42, P2476, DOI 10.1007/s10803-012-1493-0
   McDuffie A, 2013, J AUTISM DEV DISORD, V43, P1676, DOI 10.1007/s10803-012-1717-3
   McKean C, 2013, J CHILD LANG, V40, P307, DOI 10.1017/S0305000911000444
   Merriam-Webster, 1967, WEBSTERS 7 COLLEGIAT
   Mullen E, 1995, MULLEN SCALES EARLY
   Naigles LR, 2011, AUTISM RES, V4, P422, DOI 10.1002/aur.223
   Noland JS, 2010, DEVELOPMENTAL SCI, V13, P244, DOI 10.1111/j.1467-7687.2009.00882.x
   Nusbaum H., 1984, 10 IND U SPEECH RES
   Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x
   Ray-Subramanian CE, 2012, J AUTISM DEV DISORD, V42, P2113, DOI 10.1007/s10803-012-1463-6
   Ray-Subramanian CE, 2011, J AUTISM DEV DISORD, V41, P679, DOI 10.1007/s10803-010-1083-y
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Saffran JR, 1996, SCIENCE, V274, P1926, DOI 10.1126/science.274.5294.1926
   Saffran JR, 2003, DEV PSYCHOL, V39, P484, DOI 10.1037/0012-1649.39.3.484
   Scott-Van Zeeland AA, 2010, BIOL PSYCHIAT, V68, P345, DOI 10.1016/j.biopsych.2010.01.011
   Stokes SF, 2014, J CHILD LANG, V41, P634, DOI 10.1017/S030500091300010X
   Stokes SF, 2010, J SPEECH LANG HEAR R, V53, P670, DOI 10.1044/1092-4388(2009/08-0254)
   Stokes SF, 2012, J SPEECH LANG HEAR R, V55, P1265, DOI 10.1044/1092-4388(2012/10-0291)
   Stokes SF, 2012, J CHILD LANG, V39, P105, DOI 10.1017/S0305000911000031
   Storkel HL, 2009, J CHILD LANG, V36, P291, DOI 10.1017/S030500090800891X
   Storkel HL, 2010, BEHAV RES METHODS, V42, P497, DOI 10.3758/BRM.42.2.497
   Storkel HL, 2011, LANG COGNITIVE PROC, V26, P191, DOI 10.1080/01690961003787609
   Storkel HL, 2004, APPL PSYCHOLINGUIST, V25, P201
   Swingley D, 2005, COGNITIVE PSYCHOL, V50, P86, DOI 10.1016/j.cogpsych.2004.06.001
   TAGERFLUSBERG H, 1990, J AUTISM DEV DISORD, V20, P1, DOI 10.1007/BF02206853
   Tek S, 2008, AUTISM RES, V1, P208, DOI 10.1002/aur.38
   Thiessen ED, 2003, DEV PSYCHOL, V39, P706, DOI 10.1037/0012-1649.39.4.706
   Thompson S. P., 2007, LANGUAGE LEARNING DE, V3, P1, DOI DOI 10.1080/154754407093
   Thomson JM, 2005, MEM COGNITION, V33, P1210, DOI 10.3758/BF03193223
   Torkildsen JV, 2013, J SPEECH LANG HEAR R, V56, P618, DOI 10.1044/1092-4388(2012/11-0125)
   Venker CE, 2013, AUTISM RES, V6, P417, DOI 10.1002/aur.1304
   Volden J, 2011, AM J SPEECH-LANG PAT, V20, P200, DOI 10.1044/1058-0360(2011/10-0035)
   Weismer SE, 2013, APPL PSYCHOLINGUIST, V34, P69, DOI 10.1017/S0142716411000610
   Weismer SE, 2011, J AUTISM DEV DISORD, V41, P1065, DOI 10.1007/s10803-010-1134-4
   Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
NR 69
TC 0
Z9 0
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
EI 1558-9102
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD AUG
PY 2014
VL 57
IS 4
BP 1428
EP 1441
DI 10.1044/2014_JSLHR-L-13-0006
PG 14
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AZ4NF
UT WOS:000348198000024
PM 24687027
ER

PT J
AU Langone, SR
   Luiselli, JK
   Galvin, D
   Hamill, J
AF Langone, Serra R.
   Luiselli, James K.
   Galvin, Denise
   Hamill, Jessica
TI Effects of Fixed-Time Release Fading on Frequency and Duration of
   Aggression-Contingent Physical Restraint (Protective Holding) in a Child
   With Autism
SO CLINICAL CASE STUDIES
LA English
DT Article
DE physical restraint; autism; aggression; restraint reduction; fixed-time
   release fading
ID BEHAVIOR; INJURY; STAFF; IMPLEMENTATION; INTERVENTION; DISABILITIES;
   ADOLESCENTS; PEOPLE; SAFETY
AB We report the case of an 11-year-old boy with autism who displayed aggressive behavior and required aggression-contingent physical restraint (protective holding) to protect peers and teachers from injury. During a baseline phase, teachers implemented the boy's behavior support plan and applied protective holding according to a behavior-contingent release (BCR) criterion in which they maintained physical contact with him until he was "calm" for a minimum of 30 consecutive seconds. In the intervention phase, baseline procedures remained in effect, but the teachers terminated protective holding with the boy according to a fixed-time release (FTR) criterion that was independent of his behavior during protective holding and faded (decreased) systematically over time. In contrast to BCR, FTR fading was associated with less exposure to and fewer applications of protective holding. Post-intervention and follow-up results revealed that protective holding was no longer required. We discuss the clinical implications of these findings.
C1 [Langone, Serra R.; Luiselli, James K.; Galvin, Denise; Hamill, Jessica] May Inst, Randolph, MA 02368 USA.
RP Luiselli, JK (reprint author), May Inst, 41 Pacella Pk Dr, Randolph, MA 02368 USA.
EM jluiselli@mayinstitute.org
CR American Psychological Association, 1994, GUID EFF TREATM PERS
   Association of Professional Behavior Analysts, 2010, POS STAT US RESTR SE
   BIJOU SW, 1968, J APPL BEHAV ANAL, V1, P175, DOI 10.1901/jaba.1968.1-175
   Cipani E, 2011, FUNCTIONAL BEHAV ASS
   Cunningham J, 2003, RES DEV DISABIL, V24, P307, DOI 10.1016/S0891-4222(03)00044-1
   DiGennaro Reed F., 2011, TEACHING BEHAV SUPPO, P38
   Donat DC, 1998, J BEHAV THER EXP PSY, V29, P13, DOI 10.1016/S0005-7916(97)00039-6
   FAVELL JE, 1978, J APPL BEHAV ANAL, V11, P225, DOI 10.1901/jaba.1978.11-225
   Harris J, 1996, RES DEV DISABIL, V17, P99, DOI 10.1016/0891-4222(95)00036-4
   HILL J, 1987, MENT RETARD, V25, P141
   Kazdin A. E., 2011, SINGLE CASE RES DESI
   Kleinmann AE, 2009, J DEV PHYS DISABIL, V21, P473, DOI 10.1007/s10882-009-9157-5
   Lennox D., 2011, HDB HIGH RISK CHALLE, P271
   Lerman DC, 1997, J APPL BEHAV ANAL, V30, P187, DOI 10.1901/jaba.1997.30-187
   Luiselli J. K., 2004, MENTAL HLTH ASPECTS, V7, P91
   Luiselli J. K., 2011, HDB HIGH RISK CHALLE, P243
   Luiselli J. K., 2008, MENTAL HLTH ASPECTS, V11, P1
   Luiselli JK, 2000, BEHAV INTERVENT, V15, P317, DOI 10.1002/1099-078X(200010/12)15:4<317::AID-BIN64>3.3.CO;2-X
   Luiselli JK, 2005, BEHAV INTERVENT, V20, P51, DOI 10.1002/bin.170
   Luiselli JK, 2006, BEHAV MODIF, V30, P442, DOI 10.1177/0145445504267400
   Luiselli JK, 2009, J APPL RES INTELLECT, V22, P126, DOI 10.1111/j.1468-3148.2008.00479.x
   Magee SK, 2001, J APPL BEHAV ANAL, V34, P501, DOI 10.1901/jaba.2001.34-501
   McGlynn A. P., 2003, ETHICAL APPROACHES P, P203
   Reed D. D., 2013, HDB CRISIS INTERVENT, P107
   Reed D. D., 2013, HDB CRISIS INTERVENT
   Ryan J. B., 2009, ED TREATMENT CHILDRE, V32, P487, DOI DOI 10.1353/ETC.0.0062
   Sanders K, 2009, J APPL RES INTELLECT, V22, P216, DOI 10.1111/j.1468-3148.2008.00491.x
   Singh N. N., 1999, J CHILD FAM STUD, V8, P243, DOI 10.1023/A:1022039711096
   SPREAT S, 1986, APPL RES MENT RETARD, V7, P475, DOI 10.1016/S0270-3092(86)80020-0
   Williams DE, 2010, RES DEV DISABIL, V31, P1142, DOI 10.1016/j.ridd.2010.07.014
   Williams DE, 2009, J APPL RES INTELLECT, V22, P135, DOI 10.1111/j.1468-3148.2008.00480.x
NR 31
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-6501
EI 1552-3802
J9 CLIN CASE STUD
JI Clin. Case Stud.
PD AUG
PY 2014
VL 13
IS 4
BP 313
EP 321
DI 10.1177/1534650113509305
PG 9
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AW9PK
UT WOS:000346589300002
ER

PT J
AU Kover, ST
   Haebig, E
   Oakes, A
   McDuffie, A
   Hagerman, RJ
   Abbeduto, L
AF Kover, Sara T.
   Haebig, Eileen
   Oakes, Ashley
   McDuffie, Andrea
   Hagerman, Randi J.
   Abbeduto, Leonard
TI Sentence Comprehension in Boys With Autism Spectrum Disorder
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE autism; grammar; syntax; receptive language; intellectual disability
ID FRAGILE-X-SYNDROME; DEVELOPMENTAL TRAJECTORIES; INTELLECTUAL
   DISABILITIES; METHODOLOGICAL ISSUES; LANGUAGE-ACQUISITION;
   PRESCHOOL-CHILDREN; ADOLESCENTS; SKILLS; IMPAIRMENT; DELAY
AB Purpose: Previous research has suggested that language comprehension might be particularly impaired in children with autism spectrum disorder (ASD), but this profile has been only broadly characterized. In the current study, the authors examined sentence comprehension in school-age boys with ASD, including a subgroup with intellectual disability (ID), with particular attention paid to errors that might differentiate between lexically and syntactically based difficulties.
   Method: Participants were boys with ASD (n = 45, ages 4-11 years) and younger typically developing boys (n = 45, ages 2-6 years). Comprehension was assessed with the Test for Reception of Grammar-Version 2 (TROG-2; Bishop, 2003). Error types were analyzed for a subset of items.
   Results: Boys with ASD did not differ from younger typically developing boys matched on receptive vocabulary in overall sentence comprehension on the TROG-2 or the number of lexical errors committed. In contrast, the subgroup of boys with ASD and ID (n = 16) had poorer overall performance and committed more lexical errors than younger typically developing boys matched on nonverbal cognition.
   Conclusions: On average, comprehension was delayed in school-age boys with ASD but not beyond receptive vocabulary expectations. Boys with ASD and ID, however, had a weakness in sentence comprehension beyond nonverbal cognitive expectations.
C1 [Kover, Sara T.; Haebig, Eileen] Univ Wisconsin, Waisman Ctr, Madison, WI 53706 USA.
   [Oakes, Ashley; McDuffie, Andrea; Hagerman, Randi J.; Abbeduto, Leonard] Univ Calif Davis, Davis, CA 95616 USA.
RP Kover, ST (reprint author), Univ Washington, Seattle, WA 98195 USA.
EM skover@u.washington.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Barnes KA, 2008, NEUROPSYCHOLOGY, V22, P563, DOI 10.1037/0894-4105.22.5.563
   Bates E., 1995, HDB CHILD LANGUAGE, P96
   Bishop D. V. M., 2003, TEST RECEPTION GRAMM
   Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
   Boucher J., 2008, MEMORY AUTISM, P268, DOI DOI 10.1017/CBO9780511490101.016
   Bryson SE, 2008, CAN J PSYCHIAT, V53, P449
   Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093
   Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
   Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
   de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Dockrell JE, 2011, CHILD LANG TEACH THE, V27, P223, DOI 10.1177/0265659011398671
   Dunn L. M., 2007, PEABODY PICTURE VOCA
   Eigsti IM, 2011, RES AUTISM SPECT DIS, V5, P681, DOI 10.1016/j.rasd.2010.09.001
   Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2
   Eigsti IM, 2009, J CHILD LANG, V36, P999, DOI 10.1017/S0305000909009362
   Gleitman Lila, 1990, LANG ACQUIS, V1, P3, DOI DOI 10.1207/S153278171A0101_2
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Hudry K, 2010, INT J LANG COMM DIS, V45, P681, DOI 10.3109/13682820903461493
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kover ST, 2013, J AUTISM DEV DISORD, V43, P2696, DOI 10.1007/s10803-013-1823-x
   Kover ST, 2013, AJIDD-AM J INTELLECT, V118, P3, DOI 10.1352/1944-7558-118.1.3
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Maljaars J, 2012, J AUTISM DEV DISORD, V42, P2181, DOI 10.1007/s10803-012-1476-1
   Mayo J, 2012, J AUTISM DEV DISORD, V42, P2476, DOI 10.1007/s10803-012-1493-0
   McDuffie A, 2013, J AUTISM DEV DISORD, V43, P1676, DOI 10.1007/s10803-012-1717-3
   Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
   Mervis CB, 1999, MONOGR SOC RES CHILD, V64, P115, DOI 10.1111/1540-5834.00011
   NAIGLES L, 1990, J CHILD LANG, V17, P357
   Naigles LR, 2011, AUTISM RES, V4, P422, DOI 10.1002/aur.223
   Oakes A, 2013, AM J SPEECH-LANG PAT, V22, P615, DOI 10.1044/1058-0360(2013/12-0109)
   Park CJ, 2012, J AUTISM DEV DISORD, V42, P2761, DOI 10.1007/s10803-012-1534-8
   PAUL R, 1988, J AUTISM DEV DISORD, V18, P669, DOI 10.1007/BF02211884
   PRIOR MR, 1979, J COMMUN DISORD, V12, P103, DOI 10.1016/0021-9924(79)90033-9
   Roberts JA, 2004, APPL PSYCHOLINGUIST, V25, P429, DOI 10.1017/S0142716404001201
   Roid G., 1997, LEITER INT PERFORMAN
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Swensen LD, 2007, CHILD DEV, V78, P542, DOI 10.1111/j.1467-8624.2007.01022.x
   TAGERFLUSBERG H, 1981, APPL PSYCHOLINGUIST, V2, P5, DOI 10.1017/S014271640000062X
   Thomas MSC, 2009, J SPEECH LANG HEAR R, V52, P336, DOI 10.1044/1092-4388(2009/07-0144)
   van der Schuit M, 2011, RES DEV DISABIL, V32, P1884, DOI 10.1016/j.ridd.2011.03.015
   Watanabe K, 2010, EXP BRAIN RES, V203, P233, DOI 10.1007/s00221-010-2217-3
   Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
NR 44
TC 0
Z9 1
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
EI 1558-9110
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD AUG
PY 2014
VL 23
IS 3
BP 385
EP 394
DI 10.1044/2014_AJSLP-13-0073
PG 10
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AU5ZQ
UT WOS:000345682300002
PM 24687049
ER

PT J
AU Murza, KA
   Nye, C
   Schwartz, JB
   Ehren, BJ
   Hahs-Vaughn, DL
AF Murza, Kimberly A.
   Nye, Chad
   Schwartz, Jamie B.
   Ehren, Barbara J.
   Hahs-Vaughn, Debbie L.
TI A Randomized Controlled Trial of an Inference Generation Strategy
   Intervention for Adults With High-Functioning Autism Spectrum Disorder
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE autism; intervention; language; reading; pragmatics; adults
ID ASPERGER-SYNDROME; READING-COMPREHENSION; SOCIAL-PERCEPTION;
   YOUNG-ADULTS; CHILDREN; STUDENTS; DISABILITIES; ADOLESCENTS; SKILLS;
   MIND
AB Purpose: The present intervention study investigated the efficacy of the ACT & Check Strategy intervention to improve inference generation when reading, metacognitive ability, general reading comprehension, and social inference ability in adults with high-functioning autism spectrum disorder (HF-ASD).
   Method: Twenty-five adults with HF-ASD were randomly assigned to either a treatment or a control group. Treatment sessions were conducted in 1-hr sessions, twice a week, for a total of 6 weeks. Treatment focused on explicit instruction of components of inference generation, categories of inferences, and increasingly independent strategy use.
   Results: The treatment group demonstrated significantly superior performance on 1 of 2 measures of inference generation in reading and 1 measure of metacognitive ability compared with the control group. Significant differences between groups were not found on measures of reading comprehension or social inference ability.
   Conclusion: These findings suggest that the ACT & Check Strategy was effective in improving participants' ability to generate inferences in reading and certain metacognitive abilities, but the skills do not appear to generalize to other social communication contexts, such as social inference generation. This research provides a measure of support for explicitly teaching inference generation to address a reading inference deficit in adults with HF-ASD.
C1 [Murza, Kimberly A.] Univ No Colorado, Greeley, CO 80639 USA.
   [Nye, Chad; Schwartz, Jamie B.; Ehren, Barbara J.; Hahs-Vaughn, Debbie L.] Univ Cent Florida, Orlando, FL 32816 USA.
RP Murza, KA (reprint author), Univ No Colorado, Greeley, CO 80639 USA.
EM kimberly.murza@unco.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Anderson R. C., 1984, HDB READING RES, P255
   Applegate AJ, 2009, READ TEACH, V62, P372, DOI 10.1598/RT.62.5.1
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
   Bowyer-Crane C, 2005, BRIT J EDUC PSYCHOL, V75, P189, DOI 10.1348/000709904X22674
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Bui Y. N., 2006, LEARNING DISABILITIE, V21, P244, DOI [10.1111/j.1540-5826.2006.00221.x, DOI 10.1111/J.1540-5826.2006.00221.X]
   CARNINE DW, 1982, J READING BEHAV, V14, P335
   CARR EM, 1983, J READING BEHAV, V15, P1
   CASNER-LOTTO JILL, 2006, ARE THEY REALLY READ
   David N, 2010, J AUTISM DEV DISORD, V40, P290, DOI 10.1007/s10803-009-0867-4
   DEWITZ P, 1987, READ RES QUART, V22, P99, DOI 10.2307/747723
   Dotson WH, 2010, RES AUTISM SPECT DIS, V4, P199, DOI 10.1016/j.rasd.2009.09.005
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Ehren B. J., 2010, PERSPECTIVES LANGUAG, V19, P93
   Ehren B. J., 2008, STRUCTURE YOUR READI
   ELLIS ES, 1991, FOCUS EXCEPT CHILD, V23, P1
   Fisher J. B., 2002, COMPREHENSION INSTRU, P351
   Flores M. M., 2007, FOCUS AUTISM OTHER D, V22, P244, DOI 10.1177/10883576070220040601
   Flores MM, 2009, EDUC TRAIN DEV DISAB, V44, P39
   Frith U., 1989, AUTISM EXPLAINING EN
   Fritschmann N. S., 2006, THESIS
   Goode S., 1994, 13 BIENN M INT SOC S
   Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530
   Gresham FM, 2001, EXCEPT CHILDREN, V67, P331
   Hall G. E., 2006, IMPLEMENTING CHANGE, V2nd
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Hedges L, 1985, STAT METHODS METAANA
   Hendrickx S., 2008, LOVE SEX LONG TERM R
   Hollis S, 1999, BRIT MED J, V319, P670
   Howlin P., 1997, AUTISM PREPARING ADU
   Howlin P., 1998, AUTISM PERVASIVE DEV, P209
   Howlin P., 1996, EVALUATION PILOT 2 Y
   Huemer S. V., 2009, J AUTISM DEV DISORD, V40, P485, DOI [10. 1007/ s10803- 009- 0892- 3, DOI 10.1007/S10803-009-0892-3]
   Hughes C. A., 2002, LEARNING DISABILITIE, V17, P1, DOI 10.1111/1540-5826.00028
   Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
   Jarbrink K, 2007, RES DEV DISABIL, V28, P94, DOI 10.1016/j.ridd.2005.11.002
   Kaland N, 2005, EUR CHILD ADOLES PSY, V14, P73, DOI 10.1007/s00787-005-0434-2
   Kaland N, 2002, J CHILD PSYCHOL PSYC, V43, P517, DOI 10.1111/1469-7610.00042
   Lancaster PE, 2009, LEARN DISABILITY Q, V32, P165
   Langer JA, 2001, AM EDUC RES J, V38, P837, DOI 10.3102/00028312038004837
   LENZ BK, 1990, J LEARN DISABIL, V23, P149
   Loukusa S, 2009, RES AUTISM SPECT DIS, V3, P890, DOI 10.1016/j.rasd.2009.05.002
   Lounds Taylor J., 2012, AHRQ PUBLICATION, V65
   MAGLIANO JP, 1996, ADV DISC PROCESS, V52, P201
   McDonald S, 2006, DISABIL REHABIL, V28, P1529, DOI 10.1080/09638280600646185
   McDonald S, 2004, NEUROPSYCHOL REHABIL, V14, P285, DOI 10.1080/09602010343000237
   McDonald S., 2002, AWARENESS SOCIAL INF
   Mesibov G. B., 1997, AUTISM UNDERSTANDING
   Murza K. A., 2011, INFERENCE GENERATION
   Nation K, 1999, PSYCHOL BULL, V125, P338, DOI 10.1037/0033-2909.125.3.338
   Nation K, 2006, J AUTISM DEV DISORD, V36, P911, DOI 10.1007/s10803-006-0130-1
   Nesbitt S., 2000, AUTISM, V4, P357, DOI [10. 1177/ 1362361300004004002, DOI 10.1177/1362361300004004002]
   O'Connor IM, 2004, J AUTISM DEV DISORD, V34, P115, DOI 10.1023/B:JADD.0000022603.44077.6b
   Palmen A, 2012, RES AUTISM SPECT DIS, V6, P602, DOI 10.1016/j.rasd.2011.10.001
   Palmen A, 2008, AUTISM, V12, P83, DOI 10.1177/1362361307085265
   Partnership for 21st Century Skills, 2010, PRINC REC 21 CENT RE
   Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
   Puma M. J., 2009, WHAT DO WHEN DATA AR
   Randi J, 2010, J AUTISM DEV DISORD, V40, P890, DOI 10.1007/s10803-010-0938-6
   Reichow B, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008511.pub2
   REUTZEL DR, 1988, READ RES QUART, V23, P358, DOI 10.2307/748047
   Schumaker J. B., 1992, CONT INTERVENTION RE, P22
   Schumaker J. B., 1982, COMING AGE, V3, P170
   Seybert L., 1998, THESIS
   Smith Myles B., 2002, FOCUS AUTISM OTHER D, V17, P44
   Snow C. E., 2002, READING UNDERSTANDIN
   Spargo E., 1989, TIMED READINGS LIT B
   Stichter JP, 2010, J AUTISM DEV DISORD, V40, P1067, DOI [10.1007/s10803-010-0959-1, 10.1007/s10803-010-0968-0]
   Streiner D. L., 2002, CAN J PSYCHIAT, V47, P70
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335
   Torgerson DJ, 2008, DESIGNING RANDOMISED TRIALS IN HEALTH, EDUCATION AND THE SOCIAL SCIENCES: AN INTRODUCTION, P1, DOI 10.1057/9780230583993
   Turner-Brown LM, 2008, J AUTISM DEV DISORD, V38, P1777, DOI 10.1007/s10803-008-0545-y
   Valenti M., 2010, CHILD ADOL PSYCH CL, V4, P1
   Wahlberg T, 2004, DISCOURSE PROCESS, V38, P119, DOI 10.1207/s15326950dp3801_5
   Watson G., 1964, WATSON GLASER CRITIC
   Westbrook J. D., 2012, CAMPBELL SYSTEMATIC, V5, DOI [10.4073/csr.2012.5, DOI 10.4073/CSR.2012.5]
   Westby C, 2004, CHALLENGES LANG LITE, P398
   Williams K. T., 2001, GRADE GROUP READING
   Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0
NR 82
TC 0
Z9 0
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
EI 1558-9110
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD AUG
PY 2014
VL 23
IS 3
BP 461
EP 473
DI 10.1044/2014_AJSLP-13-0012
PG 13
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AU5ZQ
UT WOS:000345682300008
PM 24687182
ER

PT J
AU Thiemann-Bourque, KS
   Warren, SF
   Brady, N
   Gilkerson, J
   Richards, JA
AF Thiemann-Bourque, Kathy S.
   Warren, Steven F.
   Brady, Nancy
   Gilkerson, Jill
   Richards, Jeffrey A.
TI Vocal Interaction Between Children With Down Syndrome and Their Parents
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE Down syndrome; speech development; parent-child communication;
   vocalizations; automated vocal analysis
ID YOUNG-CHILDREN; INTELLECTUAL DISABILITIES; INFANT VOCALIZATIONS;
   COMMUNICATION; INTERVENTION; AUTISM; WORDS; PAIRS
AB Purpose: The purpose of this study was to describe differences in parent input and child vocal behaviors of children with Down syndrome (DS) compared with typically developing (TD) children. The goals were to describe the language learning environments at distinctly different ages in early childhood.
   Method: Nine children with DS and 9 age-matched TD children participated; 4 children in each group were ages 9-11 months, and 5 were between 25 and 54 months. Measures were derived from automated vocal analysis. A digital language processor measured the richness of the child's language environment, including number of adult words, conversational turns, and child vocalizations.
   Results: Analyses indicated no significant differences in words spoken by parents of younger versus older children with DS and significantly more words spoken by parents of TD children than parents of children with DS. Differences between the DS and TD groups were observed in rates of all vocal behaviors, with no differences noted between the younger versus older children with DS, and the younger TD children did not vocalize significantly more than the younger DS children.
   Conclusions: Parents of children with DS continue to provide consistent levels of input across the early language learning years; however, child vocal behaviors remain low after the age of 24 months, suggesting the need for additional and alternative intervention approaches.
C1 [Thiemann-Bourque, Kathy S.; Warren, Steven F.; Brady, Nancy] Univ Kansas, Lawrence, KS 66045 USA.
   [Gilkerson, Jill; Richards, Jeffrey A.] LENA Res Fdn, Boulder, CO USA.
RP Thiemann-Bourque, KS (reprint author), Univ Kansas, Lawrence, KS 66045 USA.
EM thiemann@ku.edu
CR Abbeduto L, 2007, MENT RETARD DEV D R, V13, P247, DOI 10.1002/mrdd.20159
   BERGER J, 1983, DEV PSYCHOL, V19, P322
   Brady N., 2008, SPEECH LANGUAGE DEV, P173
   Caselli MC, 1998, J SPEECH LANG HEAR R, V41, P1125
   Christakis DA, 2009, ARCH PEDIAT ADOL MED, V163, P554, DOI 10.1001/archpediatrics.2009.61
   Gilkerson J., 2008, LTR022 LENA RES FDN
   Gilkerson J., 2008, LTR062
   Girolametto L., 2007, TREATMENT LANGUAGE D, P77
   HART B, 1992, DEV PSYCHOL, V28, P1096, DOI 10.1037/0012-1649.28.6.1096
   Kumin L., 1999, INFANT TODDLER INTER, V9, P87
   LYNCH MP, 1995, AM J MENT RETARD, V100, P68
   Miller J. F., 1992, ADV MED CARE, P39
   MUNDY P, 1988, CHILD DEV, V59, P235, DOI 10.2307/1130406
   Nathani S, 2003, J CHILD LANG, V30, P3, DOI 10.1017/S0305000902005433
   Oller D. K., 2000, EMERGENCE SPEECH CAP
   Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107
   Pennington L, 2009, J SPEECH LANG HEAR R, V52, P1121, DOI 10.1044/1092-4388(2009/07-0187)
   Risley T. R., 1995, MEANINGFUL DIFFERENC
   Roach MA, 1998, DEV PSYCHOL, V34, P77, DOI 10.1037/0012-1649.34.1.77
   Romski M, 2010, J SPEECH LANG HEAR R, V53, P350, DOI 10.1044/1092-4388(2009/08-0156)
   Slonims V, 2006, AM J MENT RETARD, V111, P273, DOI 10.1352/0895-8017(2006)111[273:AOMIII]2.0.CO;2
   SMITH BL, 1981, J SPEECH HEAR DISORD, V46, P46
   Spender Q, 1996, DEV MED CHILD NEUROL, V38, P681
   SPENDER Q, 1995, EUR J DISORDER COMM, V30, P77
   TANNOCK R, 1988, AM J MENT RETARD, V93, P154
   Vilaseca R. M., 2004, CHILD LANG TEACH THE, V20, P163, DOI DOI 10.1191/0265659004CT2690A
   Warren S., 2008, SPEECH LANGUAGE DEV, P53
   Warren SF, 2007, MENT RETARD DEV D R, V13, P330, DOI 10.1002/mrdd.20177
   Warren SF, 2008, J SPEECH LANG HEAR R, V51, P451, DOI 10.1044/1092-4388(2008/033)
   Warren SF, 2010, J AUTISM DEV DISORD, V40, P555, DOI 10.1007/s10803-009-0902-5
   Xu D., 2009, LTR052 LENA RES FDN
   Xu D., 2008, LTR042 LENA RES FDN
   Yoder P, 2014, AJIDD-AM J INTELLECT, V119, P17, DOI 10.1352/1944-7558-119.1.17
   Yoder PJ, 2002, J SPEECH LANG HEAR R, V45, P1158, DOI 10.1044/1092-4388(2002/094)
   Yoder PJ, 1998, J SPEECH LANG HEAR R, V41, P1207
   Ypsilanti A, 2005, J INTELL DISABIL RES, V49, P353, DOI 10.1111/j.1365-2788.2005.00654.x
   Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 37
TC 0
Z9 0
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
EI 1558-9110
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD AUG
PY 2014
VL 23
IS 3
BP 474
EP 485
DI 10.1044/2014_AJSLP-12-0010
PG 12
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AU5ZQ
UT WOS:000345682300009
PM 24686777
ER

PT J
AU Wink, LK
   O'Melia, AM
   Shaffer, RC
   Pedapati, E
   Friedmann, K
   Schaefer, T
   Erickson, CA
AF Wink, Logan K.
   O'Melia, Anne M.
   Shaffer, Rebecca C.
   Pedapati, Ernest
   Friedmann, Katherine
   Schaefer, Tori
   Erickson, Craig A.
TI Intranasal Ketamine Treatment in an Adult With Autism Spectrum Disorder
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
C1 [Wink, Logan K.; Shaffer, Rebecca C.; Pedapati, Ernest; Friedmann, Katherine; Schaefer, Tori; Erickson, Craig A.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [O'Melia, Anne M.] Univ Cincinnati, Cincinnati, OH USA.
RP Wink, LK (reprint author), Cincinnati Childrens Hosp Med Ctr, 3333 Burnet Ave MLC 4002, Cincinnati, OH 45229 USA.
EM logan.wink@cchmc.org
FU Simons Foundation; John Merck Fund; US Department of Defense; Autism
   Speaks; SynapDx; Cures Within Reach; Angelman Syndrome Foundation
FX Dr Wink has been a consultant for Otsuka and has received grant/research
   support from Simons Foundation, John Merck Fund, US Department of
   Defense, Autism Speaks, SynapDx, and Cures Within Reach. Dr Shaffer has
   received grant/research support from Autism Speaks. Dr Erickson has been
   a consultant for Alcobra, Roche Group, and Confluence Pharmaceuticals;
   has received grant/research support from Simons Foundation, Angelman
   Syndrome Foundation, John Merck Fund, US Department of Defense, and
   Autism Speaks; and is a stock shareholder in Confluence Pharmaceuticals.
   Drs O'Melia, Pedapati, and Schaefer and Ms Friedmann report no potential
   conflict of interest.
CR Papolos DF, 2013, J AFFECT DISORDERS, V147, P431, DOI 10.1016/j.jad.2012.08.040
   Tottenham N, 2002, 9 ANN M COGN NEUR SO
   Zarate CA, 2006, ARCH GEN PSYCHIAT, V63, P856, DOI 10.1001/archpsyc.63.8.856
NR 3
TC 0
Z9 0
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD AUG
PY 2014
VL 75
IS 8
BP 835
EP 836
DI 10.4088/JCP.13cr08917
PG 2
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AU3RC
UT WOS:000345530300010
PM 25191906
ER

PT J
AU Du Bois, JW
   Hobson, RP
   Hobson, JA
AF Du Bois, John W.
   Hobson, R. Peter
   Hobson, Jessica A.
TI Dialogic resonance and intersubjective engagement in autism
SO COGNITIVE LINGUISTICS
LA English
DT Article
DE autism; resonance; dialogic syntax; structural priming;
   intersubjectivity; identification; stance; attitude; linkage; engagement
ID LANGUAGE PRODUCTION; JOINT ATTENTION; CHILDREN; COMMUNICATION;
   IDENTIFICATION; CONVERSATION; IMPAIRMENTS; PSYCHOLOGY; IMITATION;
   DISORDER
AB How can we investigate the relation between language and the human capacity for intersubjective engagement? Here we combine insights from linguistics and psychology to study the language of children with autism. We begin by reviewing why it might be worthwhile to study autism from the perspective of dialogic resonance, defined as the catalytic activation of affinities across utterances. Then we report on a controlled study of conversations involving individual children with autism and an interested adult interviewer. According to reliable ratings of the transcribed conversations, each considered as a whole, the speech of participants with autism was characterized by atypical forms of dialogic resonance. On the other hand, the children with autism were similar to control participants insofar as their conversations manifested "typically developed frame grabs" in which dialogic resonance was accompanied by a coherent expansion. These findings were compatible with those that emerged from utterance-by-utterance analyses of the same conversations reported elsewhere (Hobson et al. 2012). To complement the quantitative findings, we present illustrative excerpts of language use. We consider how dialogic resonance relates to structural priming, and consider implications for understanding the relations among intersubjectivity, language, and autism.
C1 [Du Bois, John W.] Univ Calif Santa Barbara, Dept Linguist, Santa Barbara, CA 93106 USA.
   [Hobson, R. Peter] UCL, Tavistock Clin, London WC1E 6BT, England.
   [Hobson, R. Peter] UCL, Inst Child Hlth, London WC1E 6BT, England.
   [Hobson, Jessica A.] Sonoma State Univ & Univ Coll, London, England.
RP Du Bois, JW (reprint author), Univ Calif Santa Barbara, Dept Linguist, Santa Barbara, CA 93106 USA.
EM dubois@linguistics.ucsb.edu; r.hobson@ucl.ac.uk;
   jessica.hobson@sonoma.edu
CR Adams C, 2002, J CHILD PSYCHOL PSYC, V43, P679, DOI 10.1111/1469-7610.00056
   Allen ML, 2011, DEVELOPMENTAL SCI, V14, P540, DOI 10.1111/j.1467-7687.2010.01001.x
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Baltaxe CA, 1977, J PEDIATR PSYCHOL, V2, P176, DOI DOI 10.1093/JPEPSY/2.4.176
   BOCK JK, 1982, PSYCHOL REV, V89, P1, DOI 10.1037/0033-295X.89.1.1
   BOCK JK, 1986, COGNITIVE PSYCHOL, V18, P355, DOI 10.1016/0010-0285(86)90004-6
   Bois Du, 2013, REPRESENTING DISCOUR
   Bosch Gerhard, 1970, INFANTILE AUTISM CLI
   Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002
   Chafe W., 1994, DISCOURSE CONSCIOUSN
   Chang F, 2006, PSYCHOL REV, V113, P234, DOI 10.1037/0033-295X.113.2.234
   Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
   Dobbinson S, 1998, J COMMUN DISORD, V31, P113, DOI 10.1016/S0021-9924(97)00085-3
   Du Bois J. W., 2007, STANCETAKING DISCOUR, P139, DOI [10.1075/pbns.164, DOI 10.1075/PBNS.164.07DU]
   Du Bois John W., REASONS RES IN PRESS
   Dunn L M., 1982, BRIT PICTURE VOCABUL
   EALES MJ, 1993, J AUTISM DEV DISORD, V23, P593, DOI 10.1007/BF01046104
   Gallagher Shaun, 2007, PHENOMENOLOGICAL MIN
   Garcia-Perez RM, 2007, J AUTISM DEV DISORD, V37, P1310, DOI 10.1007/s10803-006-0276-x
   Garrod S, 2004, TRENDS COGN SCI, V8, P8, DOI 10.1016/j.tics.2003.10.016
   Gernsbacher MA, 2005, TRENDS LANG ACQUIS R, V4, P73
   Gibson J. J., 1979, ECOLOGICAL APPROACH
   Gries ST, 2005, J PSYCHOLINGUIST RES, V34, P365, DOI 10.1007/s10936-005-6139-3
   Hale CM, 2005, J AUTISM DEV DISORD, V35, P519, DOI 10.1007/s10803-005-5065-4
   HAPPE FGE, 1993, COGNITION, V48, P101, DOI 10.1016/0010-0277(93)90026-R
   Hobson JA, 2007, DEV PSYCHOPATHOL, V19, P411, DOI 10.1017/S0954579407070204
   Hobson R. P., 2002, CRADLE THOUGHT
   Hobson R. Peter, 1993, AUTISM DEV MIND
   Hobson RP, 2009, NEW IDEAS PSYCHOL, V27, P243, DOI 10.1016/j.newideapsych.2008.04.005
   Hobson RP, 1998, J AUTISM DEV DISORD, V28, P117, DOI 10.1023/A:1026088531558
   HOBSON RP, 1991, BRIT J DEV PSYCHOL, V9, P33
   Hobson RP, 2012, J AUTISM DEV DISORD, V42, P2718, DOI 10.1007/s10803-012-1528-6
   Hobson RP, 2007, SOC NEUROSCI-UK, V2, P320, DOI 10.1080/17470910701376852
   Kanner L, 1943, NERV CHILD, V2, P217
   Koegel LK, 2000, J AUTISM DEV DISORD, V30, P383, DOI 10.1023/A:1005539220932
   Lee A, 1998, J CHILD PSYCHOL PSYC, V39, P1131, DOI 10.1111/1469-7610.00417
   Maynard DW, 2005, SOC PROBL, V52, P499, DOI 10.1525/sp.2005.52.4.499
   MEDIN DL, 1993, PSYCHOL REV, V100, P254, DOI 10.1037/0033-295X.100.2.254
   Ochs E, 2001, SOC DEV, V10, P399, DOI 10.1111/1467-9507.00172
   Ochs E, 2004, DISCOURSE STUD, V6, P147, DOI 10.1177/1461445604041766
   Ochs E, 2005, DISCOURSE STUD, V7, P547, DOI 10.1177/1461445605054406
   Ochs Elinor, 2005, COMPANION PSYCHOL AN, P140, DOI 10.1002/9780470996409.ch9
   Pickering MJ, 2004, BEHAV BRAIN SCI, V27, P169
   Pickering MJ, 2008, PSYCHOL BULL, V134, P427, DOI 10.1037/0033-2909.134.3.427
   Pickering MJ, 1998, J MEM LANG, V39, P633, DOI 10.1006/jmla.1998.2592
   PRIZANT BM, 1987, J AM ACAD CHILD PSY, V26, P472, DOI 10.1097/00004583-198707000-00002
   Reichler Robert, 1986, CHILDHOOD AUTISM SCA
   Rollins PR, 1998, J CHILD LANG, V25, P653
   Sterponi L, 2014, J CHILD LANG, V41, P275, DOI 10.1017/S0305000912000682
   SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   Sterponi L, 2004, DISCOURSE STUD, V6, P207, DOI 10.1177/1461445604041768
   TAGERFLUSBERG H, 1991, J CHILD PSYCHOL PSYC, V32, P1123, DOI 10.1111/j.1469-7610.1991.tb00353.x
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335
   Tomasello M., 1999, CULTURAL ORIGINS HUM
   Trevarthen C., 1979, SPEECH BEGINNING INT, P321
   Vygotsky Lev Semyonovitch, 1986, THOUGHT LANGUAGE
   Weber Elizabeth, 2003, PREFERRED ARGUMENT S, P353
   Wertsch J., 1998, MIND ACTION
   Wimpory DC, 2000, J AUTISM DEV DISORD, V30, P525, DOI 10.1023/A:1005683209438
NR 60
TC 0
Z9 0
PU DE GRUYTER MOUTON
PI BERLIN
PA GENTHINER STRASSE 13, 10785 BERLIN, GERMANY
SN 0936-5907
EI 1613-3641
J9 COGN LINGUIST
JI Cogn. Linguist
PD AUG
PY 2014
VL 25
IS 3
SI SI
BP 411
EP 441
DI 10.1515/cog-2014-0025
PG 31
WC Linguistics; Language & Linguistics
SC Linguistics
GA AT7EB
UT WOS:000345098600003
ER

PT J
AU Charles, R
   Sakurai, T
   Takahashi, N
   Elder, GA
   Sosa, MAG
   Young, LJ
   Buxbaum, JD
AF Charles, Rhonda
   Sakurai, Takeshi
   Takahashi, Nagahide
   Elder, Gregory A.
   Sosa, Miguel A. Gama
   Young, Larry J.
   Buxbaum, Joseph D.
TI Introduction of the human AVPR1A gene substantially alters brain
   receptor expression patterns and enhances aspects of social behavior in
   transgenic mice
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
DE AVPR1A; Humanized mouse; Social behavior; Species-specific;
   Microsatellite; Autism
ID ANXIETY-RELATED BEHAVIOR; VASOPRESSIN RECEPTOR; KNOCKOUT MICE; PREPULSE
   INHIBITION; PROMOTER REGION; PSYCHIATRIC-DISORDERS; MONOGAMOUS VOLE;
   BINDING-SITES; MESSENGER-RNA; V-1A RECEPTOR
AB Central arginine vasopressin receptor 1A(AVPR1A) modulates a wide range of behaviors, including stress management and territorial aggression, as well as social bonding and recognition. Inter- and intra-species variations in the expression pattern of AVPR1A in the brain and downstream differential behavioral phenotypes have been attributed to differences in the non-coding regions of the AVPR1A gene, including polymorphic elements within upstream regulatory areas. Gene association studies have suggested a link between AVPR1A polymorphisms and autism, and AVPR1A has emerged as a potential pharmacological target for treatment of social cognitive impairments and mood and anxiety disorders. To further investigate the genetic mechanism giving rise to species differences in AVPR1A expression patterns and associated social behaviors, and to create a preclinical mouse model useful for screening drugs targeting AVPR1A, we engineered and extensively characterized bacterial artificial chromosome(BAC) transgenic mice harboring the entire human AVPR1A locus with the surrounding regulatory elements. Compared with wild-type animals, the humanized mice displayed a more widely distributed ligand-AVPR1A binding pattern, which overlapped with that of primates. Furthermore, humanized AVPR1A mice displayed increased reciprocal social interactions compared with wild-type animals, but no differences in social approach and preference for social novelty were observed. Aspects of learning and memory, specifically novel object recognition and spatial relocation recognition, were unaffected. The biological alterations in humanized AVPR1A mice resulted in the rescue of the prepulse inhibition impairments that were observed in knockout mice, indicating conserved functionality. Although further behavioral paradigms and additional cohorts need to be examined in humanized AVPR1A mice, the results demonstrate that species-specific variations in the genomic content of regulatory regions surrounding the AVPR1A locus are responsible for differential receptor protein expression patterns across species and that they are likely to contribute to species-specific behavioral variation. The humanized AVPR1A mouse is a potential preclinical model for further understanding the regulation of receptor gene expression and the impact of variation in receptor expression on behaviors, and should be useful for screening drugs targeting human AVPR1A, taking advantage of the expression of human AVPR1A in human-relevant brain regions.
C1 [Charles, Rhonda; Sakurai, Takeshi; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
   [Charles, Rhonda; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
   [Sakurai, Takeshi; Takahashi, Nagahide; Elder, Gregory A.; Sosa, Miguel A. Gama; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Elder, Gregory A.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA.
   [Elder, Gregory A.] James J Peters VA Med Ctr, Neurol Serv, Bronx, NY 10468 USA.
   [Sosa, Miguel A. Gama] James J Peters VA Med Ctr, Res & Dev Serv, Bronx, NY 10468 USA.
   [Young, Larry J.] Emory Univ, Yerkes Natl Primate Res Ctr, Dept Psychiat & Behav Sci, Ctr Translat Social Neurosci, Atlanta, GA 30329 USA.
   [Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
   [Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
   [Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
RP Buxbaum, JD (reprint author), Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
FU Seaver Foundation; Autism Science Foundation; National Institutes of
   Health [MH056897, MH064692, P51OD11132]
FX This work was supported by the Seaver Foundation and a predoctoral
   fellowship from the Autism Science Foundation to R. C. Additional
   support was provided by National Institutes of Health grants [MH056897
   and MH064692 to L.J.Y. and P51OD11132 to Yerkes National Primate
   Research Center].
CR Albers HE, 2012, HORM BEHAV, V61, P283, DOI 10.1016/j.yhbeh.2011.10.007
   Appenrodt E, 1998, PHYSIOL BEHAV, V64, P543, DOI 10.1016/S0031-9384(98)00119-X
   Bachner-Melman, 2005, J INDIVID DIFFER, V26, P2
   Bachner-Melman R, 2005, PLOS GENET, V1, P394, DOI 10.1371/journal.pgen.0010042
   Bielsky IE, 2005, BEHAV BRAIN RES, V164, P132, DOI 10.1016/j.bbr.2005.06.005
   Bielsky IF, 2005, NEURON, V47, P503, DOI 10.1016/j.neuron.2005.06.031
   Bielsky IF, 2004, NEUROPSYCHOPHARMACOL, V29, P483, DOI 10.1038/sj.npp.1300360
   Braff DL, 2001, PSYCHOPHARMACOLOGY, V156, P234, DOI 10.1007/s002130100810
   Caldwell HK, 2008, PROG NEUROBIOL, V84, P1, DOI 10.1016/j.pneurobio.2007.10.007
   Donaldson ZR, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003729
   Donaldson ZR, 2008, SCIENCE, V322, P900, DOI 10.1126/science.1158668
   DuboisDauphin M, 1996, BRAIN RES, V743, P32, DOI 10.1016/S0006-8993(96)01019-0
   Ebner K, 1999, EUR J NEUROSCI, V11, P997, DOI 10.1046/j.1460-9568.1999.00508.x
   Egashira Nobuaki, 2009, Folia Pharmacologica Japonica, V134, P3
   Egashira N, 2007, BEHAV BRAIN RES, V178, P123, DOI 10.1016/j.bbr.2006.12.009
   Egashira Nobuaki, 2006, Japanese Journal of Neuropsychopharmacology, V26, P101
   Egashira N, 2004, NEUROSCI LETT, V356, P195, DOI 10.1016/j.neulet.2003.11.050
   Ferris CF, 2006, PHARMACOL BIOCHEM BE, V83, P169, DOI 10.1016/j.pbb.2006.01.001
   Hammock EAD, 2004, MOL BIOL EVOL, V21, P1057, DOI 10.1093/molbev/msh104
   Hammock EAD, 2005, GENES BRAIN BEHAV, V4, P289, DOI 10.1111/j.1601-183X.2005.00119.x
   Hammock EAD, 2002, EUR J NEUROSCI, V16, P399, DOI 10.1046/j.1460-9568.2002.02083.x
   Hammock EAD, 2005, SCIENCE, V308, P1630, DOI 10.1126/science.1111427
   Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
   INSEL TR, 1994, J NEUROSCI, V14, P5381
   Israel S, 2008, PROG BRAIN RES, V170, P435, DOI 10.1016/S0079-6123(08)00434-2
   JOHNSON AE, 1993, BRAIN RES, V622, P9, DOI 10.1016/0006-8993(93)90795-O
   Kim SJ, 2002, MOL PSYCHIATR, V7, P503, DOI 10.1038/sj.mp.4001125
   Knafo A, 2008, GENES BRAIN BEHAV, V7, P266, DOI 10.1111/j.1601-183X.2007.00341.x
   Kohl S, 2013, J PSYCHIATR RES, V47, P445, DOI 10.1016/j.jpsychires.2012.11.018
   Koshimizu TA, 2012, PHYSIOL REV, V92, P1813, DOI 10.1152/physrev.00035.2011
   Levin R, 2009, PSYCHONEUROENDOCRINO, V34, P901, DOI 10.1016/j.psyneuen.2008.12.014
   Liebsch G, 1996, NEUROSCI LETT, V217, P101, DOI 10.1016/0304-3940(96)13069-X
   Lim MM, 2004, NATURE, V429, P754, DOI 10.1038/nature02539
   LOUP F, 1991, BRAIN RES, V555, P220, DOI 10.1016/0006-8993(91)90345-V
   Manning M, 2012, J NEUROENDOCRINOL, V24, P609, DOI 10.1111/j.1365-2826.2012.02303.x
   Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
   Meyer-Lindenberg A, 2009, MOL PSYCHIATR, V14, P968, DOI 10.1038/mp.2008.54
   Ring RH, 2005, CURR PHARM DESIGN, V11, P205, DOI 10.2174/1381612053382241
   Ryckmans T, 2010, CURR OPIN DRUG DISC, V13, P538
   Simon Neal G, 2008, Recent Pat CNS Drug Discov, V3, P77, DOI 10.2174/157488908784534586
   Tansey KE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-3
   TRIBOLLET E, 1991, J RECEPTOR RES, V11, P333, DOI 10.3109/10799899109066412
   vanLonden L, 1997, NEUROPSYCHOPHARMACOL, V17, P284, DOI 10.1016/S0893-133X(97)00054-7
   Vogel F, 2012, PSYCHIAT GENET, V22, P105, DOI 10.1097/YPG.0b013e32834accad
   Volpi S, 2004, STRESS, V7, P75, DOI 10.1080/102538900410001733535
   Walum H, 2008, P NATL ACAD SCI USA, V105, P14153, DOI 10.1073/pnas.0803081105
   Wassink TH, 2004, MOL PSYCHIATR, V9, P968, DOI 10.1038/sj.mp.4001503
   Wersinger SR, 2007, GENES BRAIN BEHAV, V6, P540, DOI 10.1111/j.1601-183X.2006.00281.x
   Yang SY, 2010, NEUROSCI LETT, V479, P197, DOI 10.1016/j.neulet.2010.05.050
   Yirmiya N, 2006, MOL PSYCHIATR, V11, P488, DOI 10.1038/sj.mp.4001812
   Young LJ, 1999, NATURE, V400, P766
   Pitkow LJ, 2001, J NEUROSCI, V21, P7392
   Young LJ, 2004, NAT NEUROSCI, V7, P1048, DOI 10.1038/nn1327
   Young LJ, 1997, BEHAV NEUROSCI, V111, P599
   Young LJ, 1999, J NEUROENDOCRINOL, V11, P291
NR 55
TC 0
Z9 0
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
   CAMBS, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD AUG
PY 2014
VL 7
IS 8
BP 1013
EP 1022
DI 10.1242/dmm.017053
PG 10
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA AT5TF
UT WOS:000345004200009
PM 24924430
ER

PT J
AU Duda, M
   Kosmicki, JA
   Wall, DP
AF Duda, M.
   Kosmicki, J. A.
   Wall, D. P.
TI Testing the accuracy of an observation-based classifier for rapid
   detection of autism risk
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID DIAGNOSTIC-OBSERVATION-SCHEDULE; SPECTRUM DISORDERS; REVISED ALGORITHMS;
   ADOS SCORES; SEVERITY; CHILDREN
AB Current approaches for diagnosing autism have high diagnostic validity but are time consuming and can contribute to delays in arriving at an official diagnosis. In a pilot study, we used machine learning to derive a classifier that represented a 72% reduction in length from the gold-standard Autism Diagnostic Observation Schedule-Generic (ADOS-G), while retaining >97% statistical accuracy. The pilot study focused on a relatively small sample of children with and without autism. The present study sought to further test the accuracy of the classifier (termed the observation-based classifier (OBC)) on an independent sample of 2616 children scored using ADOS from five data repositories and including both spectrum (n = 2333) and non-spectrum (n = 283) individuals. We tested OBC outcomes against the outcomes provided by the original and current ADOS algorithms, the best estimate clinical diagnosis, and the comparison score severity metric associated with ADOS-2. The OBC was significantly correlated with the ADOS-G (r = -0.814) and ADOS-2 (r = -0.779) and exhibited >97% sensitivity and >77% specificity in comparison to both ADOS algorithm scores. The correspondence to the best estimate clinical diagnosis was also high (accuracy = 96.8%), with sensitivity of 97.1% and specificity of 83.3%. The correlation between the OBC score and the comparison score was significant (r = -0.628), suggesting that the OBC provides both a classification as well as a measure of severity of the phenotype. These results further demonstrate the accuracy of the OBC and suggest that reductions in the process of detecting and monitoring autism are possible.
C1 [Duda, M.; Wall, D. P.] Stanford Univ, Div Syst Med, Dept Pediat, Stanford, CA 94305 USA.
   [Kosmicki, J. A.] Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
   [Kosmicki, J. A.] Harvard Univ, Sch Med, Boston, MA USA.
   [Kosmicki, J. A.] Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.
RP Wall, DP (reprint author), Stanford Univ, Div Syst Med, Dept Pediat, 1265 Welch Rd, Stanford, CA 94305 USA.
EM dpwall@stanford.edu
FU Simons Foundation; Nancy Lurie Marks Family Foundation; Harvard Catalyst
   Program; National Institutes of Health [1R01MH090611-01A1]
FX Work was supported in part by funds to DPW from the Simons Foundation,
   Nancy Lurie Marks Family Foundation, the Harvard Catalyst Program, and
   grant 1R01MH090611-01A1 from the National Institutes of Health. We thank
   the reviewers whose comments substantially improved the quality of the
   manuscript. We also thank the families who contributed the data that
   made this study possible.
CR Aldridge FJ, 2012, J AUTISM DEV DISORD, V42, P294, DOI 10.1007/s10803-011-1242-9
   Bernier R, 2010, CHILD ADOL PSYCH CL, V19, P855, DOI 10.1016/j.chc.2010.07.005
   Brentani H, 2013, REV BRAS PSIQUIATR, V35, pS62, DOI 10.1590/1516-4446-2013-S104
   Daniels AM, 2014, J AM ACAD CHILD PSY, V53, P141, DOI 10.1016/j.jaac.2013.11.002
   Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention, 2014, MMWR SURVEILL SUMM, V63, P1
   Durkin MS, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011551
   Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
   Falkmer T, 2013, EUR CHILD ADOLES PSY, V22, P329, DOI 10.1007/s00787-013-0375-0
   Freund Y., 1999, P 16 INT C MACH LEAR, P124
   Gotham K, 2012, PEDIATRICS, V130, pE1278, DOI 10.1542/peds.2011-3668
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Hus V, 2014, J AUTISM DEV DISORD, V44, P2400, DOI 10.1007/s10803-012-1719-1
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Pinto-Martin JA, 2008, J DEV BEHAV PEDIATR, V29, P345, DOI 10.1097/DBP.0b013e31818914cf
   Robins DL, 2014, PEDIATRICS, V133, P37, DOI 10.1542/peds.2013-1813
   Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
   Wall DP, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.10
   Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
NR 21
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG
PY 2014
VL 4
AR e424
DI 10.1038/tp.2014.65
PG 6
WC Psychiatry
SC Psychiatry
GA AT3HR
UT WOS:000344826900005
PM 25116834
ER

PT J
AU Squillace, M
   Dodero, L
   Federici, M
   Migliarini, S
   Errico, F
   Napolitano, F
   Krashia, P
   Di Maio, A
   Galbusera, A
   Bifone, A
   Scattoni, ML
   Pasqualetti, M
   Mercuri, NB
   Usiello, A
   Gozzi, A
AF Squillace, M.
   Dodero, L.
   Federici, M.
   Migliarini, S.
   Errico, F.
   Napolitano, F.
   Krashia, P.
   Di Maio, A.
   Galbusera, A.
   Bifone, A.
   Scattoni, M. L.
   Pasqualetti, M.
   Mercuri, N. B.
   Usiello, A.
   Gozzi, A.
TI Dysfunctional dopaminergic neurotransmission in asocial BTBR mice
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; T PLUS TF/J; SOCIAL ANXIETY DISORDER; GLUR1
   AMPA RECEPTOR; MOUSE MODEL; NUCLEUS-ACCUMBENS; D2 RECEPTORS; T+TF/J
   MICE; UNUSUAL REPERTOIRE; IN-VIVO
AB Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by pronounced social and communication deficits and stereotyped behaviours. Recent psychosocial and neuroimaging studies have highlighted reward-processing deficits and reduced dopamine (DA) mesolimbic circuit reactivity in ASD patients. However, the neurobiological and molecular determinants of these deficits remain undetermined. Mouse models recapitulating ASD-like phenotypes could help generate hypotheses about the origin and neurophysiological underpinnings of clinically relevant traits. Here we used functional magnetic resonance imaging (fMRI), behavioural and molecular readouts to probe dopamine neurotransmission responsivity in BTBR T+ Itpr3(tf)/J mice (BTBR), an inbred mouse line widely used to model ASD-like symptoms owing to its robust social and communication deficits, and high level of repetitive stereotyped behaviours. C57BL/6J (B6) mice were used as normosocial reference comparators. DA reuptake inhibition with GBR 12909 produced significant striatal DA release in both strains, but failed to elicit fMRI activation in widespread forebrain areas of BTBR mice, including mesolimbic reward and striatal terminals. In addition, BTBR mice exhibited no appreciable motor responses to GBR 12909. DA D1 receptor-dependent behavioural and signalling responses were found to be unaltered in BTBR mice, whereas dramatic reductions in pre-and postsynaptic DA D2 and adenosine A2A receptor function was observed in these animals. Overall these results document profoundly compromised DA D2-mediated neurotransmission in BTBR mice, a finding that is likely to have a role in the distinctive social and behavioural deficits exhibited by these mice. Our results call for a deeper investigation of the role of dopaminergic dysfunction in mouse lines exhibiting ASD-like phenotypes, and possibly in ASD patient populations.
C1 [Squillace, M.; Errico, F.; Napolitano, F.; Di Maio, A.; Usiello, A.] Ceinge Biotecnol Avanzate, Naples, Italy.
   [Dodero, L.; Galbusera, A.; Bifone, A.; Gozzi, A.] Ist Italiano Tecnol, Ctr Neurosci & Cognit Syst, Rovereto, Italy.
   [Dodero, L.] Ist Italiano Tecnol, Genoa, Italy.
   [Federici, M.; Krashia, P.; Mercuri, N. B.] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
   [Federici, M.; Mercuri, N. B.] IRCCS Fdn Santa Lucia, Lab Neurol Sperimentale, Rome, Italy.
   [Migliarini, S.; Pasqualetti, M.] Univ Pisa, Dept Biol, Unit Cell & Dev Biol, Pisa, Italy.
   [Errico, F.; Napolitano, F.] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy.
   [Scattoni, M. L.] Ist Super Sanita, Neurotoxicol & Neuroendocrinol Sect, Dept Cell Biol & Neurosci, I-00161 Rome, Italy.
   [Usiello, A.] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, Caserta, Italy.
RP Usiello, A (reprint author), Ceinge Biotecnol Avanzate, Naples, Italy.
EM Alessandro.usiello@ceinge.it; alessandro.gozzi@iit.it
FU Istituto Italiano di Tecnologia; NARSAD, Italian Ministry of Health
   'Young investigators' [GR3-2008]; Simons Foundation [SFARI 314688]
FX The study was funded by the Istituto Italiano di Tecnologia, and
   supported by a NARSAD Independent Investigator 2013 award (AU), Italian
   Ministry of Health 'Young investigators' GR3-2008 (MLS) and by a grant
   from the Simons Foundation (SFARI 314688, AG).
CR Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
   Badaruddin DH, 2007, CHILD PSYCHIAT HUM D, V38, P287, DOI 10.1007/s10578-007-0065-6
   Beaulieu JM, 2011, PHARMACOL REV, V63, P182, DOI 10.1124/pr.110.002642
   Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Cervenka S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.40
   Chadman KK, 2011, PHARMACOL BIOCHEM BE, V97, P586, DOI 10.1016/j.pbb.2010.09.012
   Chavez B, 2006, ANN PHARMACOTHER, V40, P909, DOI 10.1345/aph.1G389
   Chugani DC, 2012, PEDIATR CLIN N AM, V59, P63, DOI 10.1016/j.pcl.2011.10.002
   Coldren JT, 2003, J GENET PSYCHOL, V164, P29
   Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x
   Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
   De Mei C, 2009, CURR OPIN PHARMACOL, V9, P53, DOI 10.1016/j.coph.2008.12.002
   Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
   Dodero L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076655
   Errico F, 2008, MOL CELL NEUROSCI, V37, P335, DOI 10.1016/j.mcn.2007.10.007
   Ferrari L, 2012, J NEUROSCI METH, V204, P9, DOI 10.1016/j.jneumeth.2011.10.020
   Floresco SB, 2007, J NEUROSCI, V27, P2045, DOI 10.1523/JNEUROSCI.5474-06.2007
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P67, DOI 10.1007/s00787-009-0043-6
   Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012
   GASPAR P, 1995, EUR J NEUROSCI, V7, P1050, DOI 10.1111/j.1460-9568.1995.tb01092.x
   Geracitano R, 2003, NEUROSCIENCE, V118, P399, DOI 10.1016/S0306-4522(02)00809-6
   Gingrich B, 2000, BEHAV NEUROSCI, V114, P173, DOI 10.1037/0735-7044.114.1.173
   Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
   Gozzi A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016406
   Gozzi A, 2013, NEUROPSYCHOPHARMACOL, V38, P2120, DOI 10.1038/npp.2013.109
   Gozzi A, 2010, NEURON, V67, P656, DOI 10.1016/j.neuron.2010.07.008
   Gozzi A, 2011, NEUROPSYCHOPHARMACOL, V36, P2431, DOI 10.1038/npp.2011.129
   Gozzi A, 2007, MAGN RESON IMAGING, V25, P826, DOI 10.1016/j.mri.2007.03.003
   Gozzi A, 2008, MAGN RESON IMAGING, V26, P999, DOI 10.1016/j.mri.2008.01.012
   Hakansson K, 2006, J NEUROCHEM, V96, P482, DOI 10.1111/j.1471-4159.2005.03558.x
   Hakansson K, 2004, EUR J NEUROSCI, V20, P1108, DOI 10.1111/j.1460-9568.2004.03547.x
   Hamilton PJ, 2013, MOL PSYCHIATR, V18, P1315, DOI 10.1038/mp.2013.102
   Han S, 2014, NEURON, V81, P1282, DOI 10.1016/j.neuron.2014.01.016
   Hettinger JA, 2008, AM J MED GENET B, V147B, P628, DOI 10.1002/ajmg.b.30655
   Hettinger Joe A, 2012, Behav Brain Funct, V8, P19, DOI 10.1186/1744-9081-8-19
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Johnson PM, 2010, NAT NEUROSCI, V13, P635, DOI 10.1038/nn.2519
   Kao FC, 2013, BRAIN STRUCT FUNCT, P1
   Khan ZU, 1998, J COMP NEUROL, V402, P353, DOI 10.1002/(SICI)1096-9861(19981221)402:3<353::AID-CNE5>3.0.CO;2-4
   Klanker M, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00201
   Knutson B, 2007, PSYCHOPHARMACOLOGY, V191, P813, DOI 10.1007/s00213-006-0686-7
   Kohls G, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-10
   Kohls G, 2012, SOCIAL COGNITIVE AFF, V8, P565, DOI 10.1093/scan/nss033
   Lau YC, 2013, J AUTISM DEV DISORD, V43, P1106, DOI 10.1007/s10803-012-1653-2
   Lindgren N, 2003, P NATL ACAD SCI USA, V100, P4305, DOI 10.1073/pnas.0730708100
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   McTighe SM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062189
   Migliarini S, 2013, MOL PSYCHIATR, V18, P1106, DOI 10.1038/mp.2012.128
   Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029
   Napolitano F, 2010, J NEUROSCI, V30, P11043, DOI 10.1523/JNEUROSCI.1682-10.2010
   Nguyen M, 2014, NEUROCHEM INT, V66, P15, DOI 10.1016/j.neuint.2014.01.002
   Oddi D, 2013, BEHAV BRAIN RES, V251, P75, DOI 10.1016/j.bbr.2013.01.002
   Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
   Pandina GJ, 2007, J AUTISM DEV DISORD, V37, P367, DOI 10.1007/s10803-006-0234-7
   Pearson BL, 2012, BEHAV BRAIN RES, V233, P99, DOI 10.1016/j.bbr.2012.04.040
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Pezze MA, 2004, PROG NEUROBIOL, V74, P301, DOI 10.1016/j.pneurobio.2004.009.004
   Reiersen Angela M, 2011, J Can Acad Child Adolesc Psychiatry, V20, P15
   Ren JQ, 2009, SYNAPSE, V63, P764, DOI 10.1002/syn.20659
   Rinaldi A, 2007, NEUROPSYCHOPHARMACOL, V32, P309, DOI 10.1038/sj.npp.1301176
   Robinson PD, 2001, AM J MED GENET, V100, P30, DOI 10.1002/ajmg.1187
   Roche KW, 1996, NEURON, V16, P1179, DOI 10.1016/S0896-6273(00)80144-0
   Rogers TD, 2013, CEREBELLUM, V12, P547, DOI 10.1007/s12311-013-0462-2
   Rouge-Pont F, 2002, J NEUROSCI, V22, P3293
   Santini E, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000308
   Sasaki M, 2010, BRAIN DEV-JPN, V32, P776, DOI 10.1016/j.braindev.2010.06.003
   Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
   Scattoni ML, 2011, GENES BRAIN BEHAV, V10, P44, DOI 10.1111/j.1601-183X.2010.00623.x
   Schneier FR, 2008, DEPRESS ANXIETY, V25, P1, DOI 10.1002/da.20268
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Schwarz AJ, 2003, MAGN RESON IMAGING, V21, P1191, DOI 10.1016/j.mri.2003.08.020
   Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
   Sforazzini F., 2013, NEUROIMAGE, V87, P403
   Sharma A, 2012, J PEDIATR HEALTH CAR, V26, P291, DOI 10.1016/j.pedhc.2011.02.008
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
   Snyder GL, 2000, J NEUROSCI, V20, P4480
   Solinas M, 2002, J NEUROSCI, V22, P6321
   Solomon M, 2011, AUTISM RES, V4, P109, DOI 10.1002/aur.177
   Spanagel R, 1999, TRENDS NEUROSCI, V22, P521, DOI 10.1016/S0166-2236(99)01447-2
   Staal WG, 2012, J AUTISM DEV DISORD, V42, P885, DOI 10.1007/s10803-011-1312-z
   Steffey MA, 2003, AM J VET RES, V64, P470, DOI 10.2460/ajvr.2003.64.470
   Svenningsson P, 2004, ANNU REV PHARMACOL, V44, P269, DOI 10.1146/annurev.pharmtox.44.101802.121415
   Svenningsson P, 2000, P NATL ACAD SCI USA, V97, P1856, DOI 10.1073/pnas.97.4.1856
   Tordoff MG, 2013, PHYSIOL GENOMICS, V45, P834, DOI 10.1152/physiolgenomics.00092.2013
   Usiello A, 2000, NATURE, V408, P199
   Valjent E, 2011, NEUROPSYCHOPHARMACOL, V36, P2561, DOI 10.1038/npp.2011.144
   Wohr M, 2011, GENES BRAIN BEHAV, V10, P35, DOI 10.1111/j.1601-183X.2010.00582.x
   Yang BZ, 2013, NAT NEUROSCI, V17, P400
   Yang M, 2012, PHYSIOL BEHAV, V107, P649, DOI 10.1016/j.physbeh.2011.12.025
   Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008
   Young JW, 2010, PSYCHOPHARMACOLOGY, V208, P443, DOI 10.1007/s00213-009-1744-8
   Zaharchuk G, 1999, STROKE, V30, P2197
   Zahm DS, 1999, ANN NY ACAD SCI, V877, P113, DOI 10.1111/j.1749-6632.1999.tb09264.x
   Zalla T, 2009, RES AUTISM SPECT DIS, V3, P913, DOI 10.1016/j.rasd.2009.03.004
   Zikopoulos B, 2013, FRONT HUM NEUROSCI, V7, P1, DOI 10.3389/fnhum.2013.00609
NR 97
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG
PY 2014
VL 4
AR e427
DI 10.1038/tp.2014.69
PG 11
WC Psychiatry
SC Psychiatry
GA AT3HR
UT WOS:000344826900008
PM 25136890
ER

PT J
AU Grainger, C
   Williams, DM
   Lind, SE
AF Grainger, Catherine
   Williams, David M.
   Lind, Sophie E.
TI Metacognition, Metamemory, and Mindreading in High-Functioning Adults
   With Autism Spectrum Disorder
SO JOURNAL OF ABNORMAL PSYCHOLOGY
LA English
DT Article
DE autism; metacognition; metamemory; feeling-of-knowing; theory of mind;
   mindreading
ID ASPERGER SYNDROME; AMNESIC PATIENTS; MEMORY; SELF; CHILDREN; MIND;
   INDIVIDUALS; EXPERIENCE; JUDGMENTS; KNOWLEDGE
AB Metacognition refers to cognition about cognition and encompasses both knowledge of cognitive processes and the ability to monitor and control one's own cognitions. The current study aimed to establish whether metacognition is impaired in autism spectrum disorder (ASD). According to some theories, the ability to represent one's own mental states (an aspect of metacognition) relies on the same mechanism as the ability to represent others' mental states ("mindreading"). Given numerous studies have shown mindreading is impaired in ASD, there is good reason to predict concurrent impairments in metacognition. Metacognition is most commonly explored in the context of memory, often by assessing people's ability to monitor their memory processes. The current study addressed the question of whether people with ASD have difficulty monitoring the contents of their memory (alongside impaired mindreading). Eighteen intellectually high-functioning adults with ASD and 18 IQ-and age-matched neurotypical adults participated. Metamemory monitoring ability and mindreading ability were assessed by using a feeling-of-knowing task and the "animations" task, respectively. Participants also completed a self-report measure of metacognitive ability. In addition to showing impaired mindreading, participants with ASD made significantly less accurate feeling-of-knowing judgments than neurotypical adults, suggesting that metamemory monitoring (an aspect of metacognition) was impaired. Conversely, participants with ASD self-reported superior metacognitive abilities compared with those reported by neurotypical participants. This study provides evidence that individuals with ASD have metamemory monitoring impairments. The theoretical and practical implications of these findings for our current understanding of metacognition in ASD and typical development are discussed.
C1 [Grainger, Catherine; Williams, David M.] Univ Kent, Sch Psychol, Keynes Coll, Canterbury CT2 7NP, Kent, England.
   [Lind, Sophie E.] City Univ London, Autism Res Grp, Dept Psychol, London, England.
RP Grainger, C (reprint author), Univ Kent, Sch Psychol, Keynes Coll, Canterbury CT2 7NP, Kent, England.
EM cg341@kent.ac.uk
CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Bastin C, 2012, HUM BRAIN MAPP, V33, P1268, DOI 10.1002/hbm.21282
   Brown A. L., 1996, INNOVATIONS LEARNING
   Carruthers P, 2009, BEHAV BRAIN SCI, V32, P121, DOI 10.1017/S0140525X09000545
   CartwrightHatton S, 1997, J ANXIETY DISORD, V11, P279, DOI 10.1016/S0887-6185(97)00011-X
   Cohen J., 1969, STAT POWER ANAL BEHA
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   COLTHEART M, 1981, Q J EXP PSYCHOL-A, V33, P497
   Dunlosky J, 2003, PSYCHOL AGING, V18, P340, DOI 10.1037/0882-7974.18.2.340
   Dunlosky J, 1998, EXP CLIN PSYCHOPHARM, V6, P77, DOI 10.1037/1064-1297.6.1.77
   Estes A, 2011, J AUTISM DEV DISORD, V41, P1044, DOI 10.1007/s10803-010-1127-3
   Farrant A, 1999, CHILD DEV, V70, P107
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
   FLAVELL JH, 1979, AM PSYCHOL, V34, P906, DOI 10.1037/0003-066X.34.10.906
   Flavell JH, 2000, INT J BEHAV DEV, V24, P15
   Frith U., 1999, MIND LANG, V14, P82, DOI [10.1111/1468-0017.00100, DOI 10.1111/1468-0017.00100]
   Fuchs LS, 2003, J EDUC PSYCHOL, V95, P306, DOI 10.1037/0022-0663.95.2.306
   Goldman A., 2006, SIMULATING MINDS PHI, DOI [10.1093/0195138929.001.0001, DOI 10.1093/0195138929.001.0001]
   GOODMAN LA, 1954, J AM STAT ASSOC, V49, P732, DOI 10.2307/2281536
   HART JT, 1965, J EDUC PSYCHOL, V56, P208, DOI 10.1037/h0022263
   Hartwig MK, 2012, BRIT J EDUC PSYCHOL, V82, P456, DOI 10.1111/j.2044-8279.2011.02038.x
   HURLBURT RT, 1994, PSYCHOL MED, V24, P385
   JANOWSKY JS, 1989, PSYCHOBIOLOGY, V17, P3
   Johnson SA, 2009, J AUTISM DEV DISORD, V39, P1706, DOI 10.1007/s10803-009-0809-1
   Jones CRG, 2009, NEUROPSYCHOLOGY, V23, P718, DOI 10.1037/a0016360
   Kelemen WL, 2000, MEM COGNITION, V28, P92, DOI 10.3758/BF03211579
   KORIAT A, 1993, PSYCHOL REV, V100, P609, DOI 10.1037/0033-295X.100.4.609
   Kucera H., 1967, COMPUTATIONAL ANAL P
   LEONESIO RJ, 1990, J EXP PSYCHOL LEARN, V16, P464, DOI 10.1037//0278-7393.16.3.464
   Lerner MD, 2012, J AUTISM DEV DISORD, V42, P2680, DOI 10.1007/s10803-012-1525-9
   Lind SE, 2014, NEUROPSYCHOLOGY, V28, P55, DOI 10.1037/neu0000005
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
   METCALFE J, 1993, J EXP PSYCHOL LEARN, V19, P851, DOI 10.1037//0278-7393.19.4.851
   Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
   Nelson T. O., 1990, PSYCHOL LEARN MOTIV, V26, P125, DOI [10.1016/S0079-7421(08) 60053-5, DOI 10.1016/S0079-7421(08)60053-5]
   Nelson TO, 2004, PSYCHOL METHODS, V9, P53, DOI 10.1037/1082-989X.9.1.53
   NELSON TO, 1984, PSYCHOL BULL, V95, P109, DOI 10.1037/0033-2909.95.1.109
   Nichols S., 2003, MINDREADING INTEGRAT, DOI [10.1093/0198236107.001.0001, DOI 10.1093/0198236107.001.0001]
   Owens JS, 2007, CLIN CHILD FAM PSYCH, V10, P335, DOI 10.1007/s10567-007-0027-3
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   SHIMAMURA AP, 1986, J EXP PSYCHOL LEARN, V12, P452, DOI 10.1037/0278-7393.12.3.452
   Sitko BM, 1998, EDUC PSYCHO, P93
   SNODGRASS JG, 1988, J EXP PSYCHOL GEN, V117, P34, DOI 10.1037//0096-3445.117.1.34
   Thiede KW, 2003, J EDUC PSYCHOL, V95, P66, DOI 10.1037/0022-0663.95.1.66
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wilkinson DA, 2010, J AUTISM DEV DISORD, V40, P1371, DOI 10.1007/s10803-010-0995-x
   Williams D, 2010, DEVELOPMENTAL SCI, V13, P307, DOI 10.1111/j.1467-7687.2009.00885.x
   Williams D, 2010, AUTISM, V14, P474, DOI 10.1177/1362361310366314
   Williams D, 2010, AUTISM, V14, P285, DOI 10.1177/1362361309344849
   Williams DM, 2009, J AUTISM DEV DISORD, V39, P865, DOI 10.1007/s10803-009-0695-6
   Wojcik DZ, 2011, MEMORY, V19, P549, DOI 10.1080/09658211.2011.590506
   Wojcik DZ, 2013, NEUROPSYCHOLOGY, V27, P19, DOI 10.1037/a0030526
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
   World Health Organization, 1993, INT CLASS MENT BEH D
   Yirmiya N, 1998, PSYCHOL BULL, V124, P283, DOI 10.1037/0033-2909.124.3.283
NR 59
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-843X
EI 1939-1846
J9 J ABNORM PSYCHOL
JI J. Abnorm. Psychol.
PD AUG
PY 2014
VL 123
IS 3
BP 650
EP 659
DI 10.1037/a0036531
PG 10
WC Psychology, Clinical; Psychology, Multidisciplinary
SC Psychology
GA AS1AH
UT WOS:000344008000016
PM 24955572
ER

PT J
AU Meaux, E
   Roux, S
   Batty, M
AF Meaux, Emilie
   Roux, Sylvie
   Batty, Magali
TI Early visual ERPs are influenced by individual emotional skills
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE facial expression of emotion; visual ERPs; emotional skills; healthy
   adults
ID EVENT-RELATED POTENTIALS; AUTISM SPECTRUM DISORDER; FACIAL EXPRESSIONS;
   BIPOLAR DISORDER; SEX-DIFFERENCES; FEARFUL FACES; CATEGORICAL
   PERCEPTION; BRAIN POTENTIALS; TIME-COURSE; SOCIAL-INTERACTION
AB Processing information from faces is crucial to understanding others and to adapting to social life. Many studies have investigated responses to facial emotions to provide a better understanding of the processes and the neural networks involved. Moreover, several studies have revealed abnormalities of emotional face processing and their neural correlates in affective disorders. The aim of this study was to investigate whether early visual event-related potentials (ERPs) are affected by the emotional skills of healthy adults. Unfamiliar faces expressing the six basic emotions were presented to 28 young adults while recording visual ERPs. No specific task was required during the recording. Participants also completed the Social Skills Inventory (SSI) which measures social and emotional skills. The results confirmed that early visual ERPs (P1, N170) are affected by the emotions expressed by a face and also demonstrated that N170 and P2 are correlated to the emotional skills of healthy subjects. While N170 is sensitive to the subject's emotional sensitivity and expressivity, P2 is modulated by the ability of the subjects to control their emotions. We therefore suggest that N170 and P2 could be used as individual markers to assess strengths and weaknesses in emotional areas and could provide information for further investigations of affective disorders.
C1 [Meaux, Emilie; Roux, Sylvie; Batty, Magali] Univ Tours, CHRU Tours, Ctr Univ Pedopsychiat, UMR Inserm U930, F-37044 Tours 9, France.
RP Meaux, E (reprint author), Univ Med Ctr, Lab Behav Neurol & Imaging Cognit LabNIC, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland.
EM Emilie.Meaux@unige.ch
FU Foundation ORANGE
FX The authors thank all the subjects for their time and effort spent
   participating in this study. Special thanks are due to Sylvie Roux for
   her valuable help with the experimental design and analyses. This work
   was supported by grants from Foundation ORANGE.
CR Addington J, 1998, SCHIZOPHR RES, V32, P171, DOI 10.1016/S0920-9964(98)00042-5
   Adolphs R, 2002, CURR OPIN NEUROBIOL, V12, P169, DOI 10.1016/S0959-4388(02)00301-X
   Aguera PE, 2011, COMPUT INTEL NEUROSC, DOI 10.1155/2011/158970
   Akechi H, 2010, NEUROPSYCHOLOGIA, V48, P2841, DOI 10.1016/j.neuropsychologia.2010.05.026
   Ashley V, 2004, NEUROREPORT, V15, P211, DOI 10.1097/01.wnr.0000091411.19795.f5
   Bastian VA, 2005, PERS INDIV DIFFER, V39, P1135, DOI 10.1016/j.paid.2005.04.006
   Batty M, 2011, J EXP CHILD PSYCHOL, V109, P430, DOI 10.1016/j.jecp.2011.02.001
   Batty M, 2003, COGNITIVE BRAIN RES, V17, P613, DOI 10.1016/S0926-6410(03)00174-5
   Batty M, 2002, PSYCHOPHYSIOLOGY, V39, P482, DOI 10.1017/S0048577202010764
   Batty M, 2006, DEVELOPMENTAL SCI, V9, P207, DOI 10.1111/j.1467-7687.2006.00480.x
   Belopolsky A. V., 2010, VIS COGN, V19, P27
   Bentin S, 1996, J COGNITIVE NEUROSCI, V8, P551, DOI 10.1162/jocn.1996.8.6.551
   Bentin S, 2006, J COGNITIVE NEUROSCI, V18, P1406, DOI 10.1162/jocn.2006.18.8.1406
   Boutsen L, 2006, NEUROIMAGE, V32, P352, DOI 10.1016/j.neuroimage.2006.03.023
   BOYATZIS CJ, 1993, J GENET PSYCHOL, V154, P375
   Brackett MA, 2004, PERS INDIV DIFFER, V36, P1387, DOI 10.1016/S0191-8869(03)00236-8
   Brackett MA, 2006, J PERS SOC PSYCHOL, V91, P780, DOI 10.1037/0022-3514.91.4.780
   Breiter HC, 1996, NEURON, V17, P875, DOI 10.1016/S0896-6273(00)80219-6
   Brosch T, 2008, PSYCHOL SCI, V19, P362, DOI 10.1111/j.1467-9280.2008.02094.x
   BRUCE V, 1986, BRIT J PSYCHOL, V77, P305
   Caharel S, 2007, SCHIZOPHR RES, V95, P186, DOI 10.1016/j.schres.2007.06.015
   Caharel S, 2005, BRAIN COGNITION, V59, P96, DOI 10.1016/j.bandc.2005.05.005
   Calder AJ, 1996, VIS COGN, V3, P81, DOI 10.1080/713756735
   Campanella S, 2004, NEUROSCI LETT, V367, P14, DOI 10.1016/j.neulet.2004.05.097
   Campanella S, 2012, PSYCHIAT RES, V197, P145, DOI 10.1016/j.psychres.2011.12.026
   Campanella S, 2002, J COGNITIVE NEUROSCI, V14, P210, DOI 10.1162/089892902317236858
   Carlson SM, 2009, CHILD DEV, V80, P1076, DOI 10.1111/j.1467-8624.2009.01318.x
   Carlson SR, 2006, PSYCHOPHYSIOLOGY, V43, P470, DOI 10.1111/j.1469-8986.2006.00450.x
   Chammat M, 2010, BRAIN RES, V1348, P95, DOI 10.1016/j.brainres.2010.05.051
   Cheung CHM, 2010, SOC NEUROSCI-UK, V5, P351, DOI 10.1080/17470911003597377
   Clark TF, 2008, EMOTION, V8, P803, DOI 10.1037/a0014124
   Dai Q, 2009, PROG NEURO-PSYCHOPH, V33, P921, DOI 10.1016/j.pnpbp.2009.04.012
   Damasio AR, 1998, BRAIN RES REV, V26, P83, DOI 10.1016/S0165-0173(97)00064-7
   Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x
   Degabriele R, 2011, J AFFECT DISORDERS, V133, P212, DOI 10.1016/j.jad.2011.03.033
   De Jong MC, 2008, J AM ACAD CHILD PSY, V47, P443, DOI 10.1097/CHI.0b013e31816429a6
   Dennis TA, 2009, DEV NEUROPSYCHOL, V34, P85, DOI 10.1080/87565640802564887
   Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
   De Sonneville LMJ, 2002, J CLIN EXP NEUROPSYC, V24, P200, DOI 10.1076/jcen.24.2.200.989
   Duval S., 2011, SOCIAL COGNITIVE AFF, V6, P90
   Eger E, 2003, NEUROPSYCHOLOGIA, V41, P808, DOI 10.1016/S0028-3932(02)00287-7
   Eimer M, 2007, NEUROPSYCHOLOGIA, V45, P15, DOI 10.1016/j.neuropsychologia.2006.04.022
   Eimer M, 2011, BRAIN RES, V1376, P76, DOI 10.1016/j.brainres.2010.12.046
   Eimer M, 1998, NEUROREPORT, V9, P2945, DOI 10.1097/00001756-199809140-00005
   Ekman P, 2003, EMOTIONS REVEALED
   Feinstein JS, 2002, NEUROREPORT, V13, P1255, DOI 10.1097/00001756-200207190-00007
   Ganis G, 2012, NEUROIMAGE, V62, P1563, DOI 10.1016/j.neuroimage.2012.05.043
   George N, 1996, COGNITIVE BRAIN RES, V4, P65, DOI 10.1016/0926-6410(95)00045-3
   Gohm CL, 2005, PERS INDIV DIFFER, V39, P1017, DOI 10.1016/j.paid.2005.03.018
   Grispan D., 2003, J GENET PSYCHOL, V164, P88
   Habel U, 2010, SOC NEUROSCI-UK, V5, P92, DOI 10.1080/17470910903170269
   Hajcak G, 2010, DEV NEUROPSYCHOL, V35, P129, DOI 10.1080/87565640903526504
   Hall JA, 2006, J NONVERBAL BEHAV, V30, P141, DOI 10.1007/s10919-006-0013-3
   HALL JA, 1978, PSYCHOL BULL, V85, P845, DOI 10.1037//0033-2909.85.4.845
   Hall JA, 2008, PERS SOC PSYCHOL B, V34, P144, DOI 10.1177/0146167207309192
   Harris A, 2008, CEREB CORTEX, V18, P467
   Hileman CM, 2011, DEV NEUROPSYCHOL, V36, P214, DOI 10.1080/87565641.2010.549870
   HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
   Holmes A, 2003, COGNITIVE BRAIN RES, V16, P174, DOI 10.1016/S0926-6410(02)00268-9
   Itier RJ, 2004, CEREB CORTEX, V14, P132, DOI 10.1093/cercor/bhg111
   Itier RJ, 2002, NEUROIMAGE, V15, P353, DOI 10.1006/nimg.2001.0982
   Itier RJ, 2006, NEUROIMAGE, V29, P667, DOI 10.1016/j.neuroimage.2005.07.041
   Jacques C, 2010, BRAIN RES, V1318, P96, DOI 10.1016/j.brainres.2009.12.070
   JEFFREYS DA, 1993, EXP BRAIN RES, V96, P163
   Jemel B, 1999, PSYCHOPHYSIOLOGY, V36, P437
   Joyce C, 2005, CLIN NEUROPHYSIOL, V116, P2613, DOI 10.1016/j.clinph.2005.07.005
   Junghofer M, 2001, PSYCHOPHYSIOLOGY, V38, P175, DOI 10.1017/S0048577201000762
   Krolak-Salmon P, 2001, EUR J NEUROSCI, V13, P987, DOI 10.1046/j.0953-816x.2001.01454.x
   LANG SF, 1990, J CLIN EXP NEUROPSYC, V12, P946, DOI 10.1080/01688639008401033
   Latinus M, 2005, J COGNITIVE NEUROSCI, V17, P1316, DOI 10.1162/0898929055002490
   Latinus M, 2006, BRAIN RES, V1123, P179, DOI 10.1016/j.brainres.2006.09.031
   Lee SH, 2010, NEUROSCI RES, V67, P172, DOI 10.1016/j.neures.2010.03.001
   Leppanen JM, 2001, SCAND J PSYCHOL, V42, P429, DOI 10.1111/1467-9450.00255
   Lewin C, 2002, BRAIN COGNITION, V50, P121, DOI 10.1016/S0278-2626(02)00016-7
   Lewin C, 2001, NEUROPSYCHOLOGY, V15, P165, DOI 10.1037//0894-4105.15.2.165
   Lewis MD, 2006, J COGNITIVE NEUROSCI, V18, P430, DOI 10.1162/089892906775990633
   Li H, 2008, NEUROIMAGE, V40, P1921, DOI 10.1016/j.neuroimage.2008.01.033
   Linkenkaer-Hansen K, 1998, NEUROSCI LETT, V253, P147, DOI 10.1016/S0304-3940(98)00586-2
   Lithari C, 2010, BRAIN TOPOGR, V23, P27, DOI 10.1007/s10548-009-0130-5
   Liu Lichan, 1999, Brain Topography, V11, P291, DOI 10.1023/A:1022258620435
   Lopes PN, 2004, PERS SOC PSYCHOL B, V30, P1018, DOI 10.1177/0146167204264762
   Lopes PN, 2005, EMOTION, V5, P113, DOI 10.1037/1528-3542.5.1.113
   Lyubomirsky S, 2005, PSYCHOL BULL, V131, P803, DOI 10.1037/0033-2909.131.6.803
   Malhi GS, 2007, BIPOLAR DISORD, V9, P345, DOI 10.1111/j.1399-5618.2007.00485.x
   Marinkovic K., 1998, PSYCHOBIOLOGY, V26, P248
   Matthews G, 2002, EMOTIONAL INTELLIGENCE: SCIENCE AND MYTH, P1
   Mayer JD, 2008, ANNU REV PSYCHOL, V59, P507, DOI 10.1146/annurev.psych.59.103006.093646
   McClure EB, 2000, PSYCHOL BULL, V126, P424, DOI 10.1037/0033-2909.126.3.424
   McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
   Morel S, 2009, BRAIN RES, V1254, P84, DOI 10.1016/j.brainres.2008.11.079
   Moser JS, 2006, PSYCHOPHYSIOLOGY, V43, P292, DOI 10.1111/j.1469-8986.2006.00402.x
   Munte TF, 1998, NEUROSCI RES, V30, P25, DOI 10.1016/S0168-0102(97)00118-1
   Nolen-Hoeksema S, 2012, ANNU REV CLIN PSYCHO, V8, P161, DOI 10.1146/annurev-clinpsy-032511-143109
   O'Connor K, 2005, BRAIN COGNITION, V59, P82, DOI 10.1016/j.bandc.2005.05.004
   Oostenveld R, 2001, CLIN NEUROPHYSIOL, V112, P713, DOI 10.1016/S1388-2457(00)00527-7
   Pallanti S, 1999, PSYCHIAT RES, V86, P239, DOI 10.1016/S0165-1781(99)00033-5
   Picton TW, 2000, PSYCHOPHYSIOLOGY, V37, P127, DOI 10.1017/S0048577200000305
   Pizzagalli DA, 2002, NEUROIMAGE, V16, P663, DOI 10.1006/nimg.2002.1126
   Pourtois G, 2005, NEUROIMAGE, V26, P149, DOI 10.1016/j.neuroimage.2005.01.015
   Pourtois G, 2004, CEREB CORTEX, V14, P619, DOI 10.1093/cercor/bhh023
   Proverbio AM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011242
   Riggio R. E., 2003, SOCIALS SKILLS MANUA
   Riggio Ronald E., 1989, MANUAL SOCIAL SKILLS
   Rosen HR, 2010, POSTGRAD MED, V122, P94, DOI 10.3810/pgm.2010.07.2177
   Rossignol M, 2012, NEUROSCI LETT, V526, P68, DOI 10.1016/j.neulet.2012.07.045
   Rossion B, 1999, BIOL PSYCHOL, V50, P173, DOI 10.1016/S0301-0511(99)00013-7
   Rossion B, 2002, COGNITION, V85, P189, DOI 10.1016/S0010-0277(02)00101-4
   Rotshtein P, 2010, HUM BRAIN MAPP, V31, P1089, DOI 10.1002/hbm.20921
   Sagiv N, 2001, J COGNITIVE NEUROSCI, V13, P937, DOI 10.1162/089892901753165854
   Sato W, 2001, NEUROREPORT, V12, P709, DOI 10.1097/00001756-200103260-00019
   Schupp HT, 2004, PSYCHOPHYSIOLOGY, V41, P441, DOI 10.1111/j.1469-8986.2004.00174.x
   Sprengelmeyer R, 2006, NEUROPSYCHOLOGIA, V44, P2899, DOI 10.1016/j.neuropsychologia.2006.06.020
   Sterzer P, 2011, PSYCHOL MED, V41, P1615, DOI 10.1017/S0033291710002540
   Streit M, 2003, NEUROSCI LETT, V342, P101, DOI 10.1016/S0304-3940(03)00274-X
   Surguladze SA, 2004, NEUROPSYCHOLOGY, V18, P212, DOI 10.1037/0894-4105.18.2.212
   Swithenby SJ, 1998, EXP BRAIN RES, V118, P501, DOI 10.1007/s002210050306
   Taylor MJ, 1999, EEG CL N SU, P145
   Taylor MJ, 2001, NEUROREPORT, V12, P1671, DOI 10.1097/00001756-200106130-00031
   Utama NP, 2009, NEUROSCI RES, V64, P30, DOI 10.1016/j.neures.2009.01.009
   Vuilleumier P, 2007, NEUROPSYCHOLOGIA, V45, P174, DOI 10.1016/j.neuropsychologia.2006.06.003
   Williams LM, 2004, HUM BRAIN MAPP, V21, P64, DOI 10.1002/hbm.10154
   Wong TKW, 2008, EUR J NEUROSCI, V28, P407, DOI 10.1111/j.1460-9568.2008.06328.x
   Wright B, 2008, AUTISM, V12, P607, DOI 10.1177/1362361308097118
   Yang JM, 2010, SCI CHINA LIFE SCI, V53, P1361, DOI 10.1007/s11427-010-4083-4
   Yuan JJ, 2012, COGN AFFECT BEHAV NE, V12, P175, DOI 10.3758/s13415-011-0064-8
   Zion-Golumbic E, 2007, CEREB CORTEX, V17, P1741, DOI 10.1093/cercor/bhl100
NR 126
TC 2
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2014
VL 9
IS 8
BP 1089
EP 1098
DI 10.1093/scan/nst084
PG 10
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AQ7IA
UT WOS:000342984900007
PM 23720573
ER

PT J
AU Schulte-Ruther, M
   Greimel, E
   Piefke, M
   Kamp-Becker, I
   Remschmidt, H
   Fink, GR
   Herpertz-Dahlmann, B
   Konrad, K
AF Schulte-Ruether, Martin
   Greimel, Ellen
   Piefke, Martina
   Kamp-Becker, Inge
   Remschmidt, Helmut
   Fink, Gereon R.
   Herpertz-Dahlmann, Beate
   Konrad, Kerstin
TI Age-dependent changes in the neural substrates of empathy in autism
   spectrum disorder
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE social cognition; theory of mind; medial prefrontal cortex; facial
   emotion; developmental trajectories
ID NETWORKS SUPPORTING EMPATHY; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME;
   RESPONSE-INHIBITION; COGNITIVE CONTROL; MIRROR NEURON; MIND; BRAIN;
   CHILDREN; SELF
AB In typical development, empathic abilities continue to refine during adolescence and early adulthood. Children and adolescents with autism spectrum disorders (ASD) show deficits in empathy, whereas adults with ASD may have developed compensatory strategies. We aimed at comparing developmental trajectories in the neural mechanisms underlying empathy in individuals with ASD and typically developing control (TDC) subjects. Using an explicit empathizing paradigm and functional magnetic resonance imaging, 27 participants with ASD and 27 TDC aged 12-31 years were investigated. Participants were asked to empathize with emotional faces and to either infer the face's emotional state (other-task) or to judge their own emotional response (self-task). Differential age-dependent changes were evident during the self-task in the right dorsolateral prefrontal cortex, right medial prefrontal cortex, right inferior parietal cortex, right anterior insula and occipital cortex. Age-dependent decreases in neural activation in TDC were paralleled by either increasing or unchanged age-dependent activation in ASD. These data suggest ASD-associated deviations in the developmental trajectories of self-related processing during empathizing. In TDC, age-dependent modulations of brain areas may reflect the 'fine-tuning' of cortical networks by reduction of task-unspecific brain activity. Increased age-related activation in individuals with ASD may indicate the development of compensatory mechanisms.
C1 [Schulte-Ruether, Martin; Greimel, Ellen; Konrad, Kerstin] Univ Hosp RWTH Aachen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Child Neuropsychol Sect, D-52074 Aachen, Germany.
   [Schulte-Ruether, Martin; Greimel, Ellen; Piefke, Martina; Fink, Gereon R.; Konrad, Kerstin] Forschungszentrum Julich, Inst Neurosci & Med INM 3, D-52425 Julich, Germany.
   [Schulte-Ruether, Martin; Herpertz-Dahlmann, Beate; Konrad, Kerstin] Univ Hosp Munich, JARA Translat Brain Med, Munich, Germany.
   [Greimel, Ellen] Univ Hosp Munich, Dept Child & Adolescent Psychiat Psychosomat & Ps, Munich, Germany.
   [Piefke, Martina] Univ Witten Herdecke, Dept Psychol & Psychotherapy, Witten, Germany.
   [Kamp-Becker, Inge; Remschmidt, Helmut] Univ Marburg, Dept Child & Adolescent Psychiat Psychosomat & Ps, Marburg, Germany.
   [Fink, Gereon R.] Univ Hosp Cologne, Dept Neurol, Cologne, Germany.
   [Herpertz-Dahlmann, Beate] Univ Hosp RWTH Aachen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany.
RP Schulte-Ruther, M (reprint author), Univ Hosp RWTH Aachen, Dept Child & Adolescent Psychiat, Child Neuropsychol Sect, Neuenhofer Weg 21, D-52074 Aachen, Germany.
EM mschulte@ukaachen.de
RI Konrad, Kerstin/H-7747-2013; Fink, Gereon/E-1616-2012
OI Konrad, Kerstin/0000-0001-9039-2615; Fink, Gereon/0000-0002-8230-1856
FU Bundeministerium fur Bildung und Forschung [01GW0751];
   Hans-Lungwitz-Foundation
FX The authors are grateful to all volunteers who took part in this study.
   They thank their colleagues in the Brain Imaging Physics (INM-4) and
   Cognitive Neuroscience groups (INM-3) at the Research Center Julich
   (Institute of Neuroscience and Medicine) and the Child Neuropsychology
   section at the University Hospital RWTH Aachen for their support and
   helpful advice. K.K. and B.H.-D. were supported by the Bundeministerium
   fur Bildung und Forschung grant 01GW0751. M. P. was supported by a grant
   from the Hans-Lungwitz-Foundation.
CR Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
   Bastiaansen JACJ, 2009, PHILOS T R SOC B, V364, P2391, DOI 10.1098/rstb.2009.0058
   Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
   Blakemore SJ, 2008, NAT REV NEUROSCI, V9, P267, DOI 10.1038/nrn2353
   Blakemore SJ, 2007, SOC COGN AFFECT NEUR, V2, P130, DOI 10.1093/scan/nsm009
   Blasi G, 2006, EUR J NEUROSCI, V23, P1658, DOI 10.1111/j.1460-9568.2006.04680.x
   Bock MA, 2001, INTERV SCH CLIN, V36, P272, DOI 10.1177/105345120103600503
   BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
   Brieber S, 2010, NEUROPSYCHOLOGIA, V48, P1644, DOI 10.1016/j.neuropsychologia.2010.02.007
   BRYANT BK, 1982, CHILD DEV, V53, P413, DOI 10.1111/j.1467-8624.1982.tb01331.x
   Bunge SA, 2002, NEURON, V33, P301, DOI 10.1016/S0896-6273(01)00583-9
   Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
   Casey BJ, 2005, TRENDS COGN SCI, V9, P104, DOI 10.1016/j.tics.2005.01.011
   Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Ciaramelli E, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00004
   Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
   Dadds MR, 2008, CHILD PSYCHIAT HUM D, V39, P111, DOI 10.1007/s10578-007-0075-4
   Davis M. H., 1980, JSAS CATALOG SELECTE, V10, P85
   Decety J, 2010, DEVELOPMENTAL SCI, V13, P886, DOI 10.1111/j.1467-7687.2009.00940.x
   Decety Jean, 2004, Behav Cogn Neurosci Rev, V3, P71, DOI 10.1177/1534582304267187
   Decety J, 2003, TRENDS COGN SCI, V7, P527, DOI 10.1016/j.tics.2003.10.004
   Decety J, 2008, NEUROPSYCHOLOGIA, V46, P2607, DOI 10.1016/j.neuropsychologia.2008.05.026
   Diamond A., 2002, PRINCIPLES FRONTAL L, P466, DOI [10.1093/acprof:oso/9780195134971.003.0029, DOI 10.1093/ACPROF:OSO/9780195134971.003.0029]
   Dondi M, 1999, DEV PSYCHOL, V35, P418, DOI 10.1037//0012-1649.35.2.418
   Dopfner M., 1994, HDB ELTERNFRAGEBOGEN
   Durston S, 2006, DEVELOPMENTAL SCI, V9, P1, DOI 10.1111/j.1467-7687.2005.00454.x
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69
   Franke G. H., 2000, SCL90R
   Frith C. D., 2006, NATURE REV NEUROSCIE, V7, P268
   Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
   Frith CD, 2008, NEURON, V60, P503, DOI 10.1016/j.neuron.2008.10.032
   Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
   Greimel E, 2010, NEUROIMAGE, V49, P1055, DOI 10.1016/j.neuroimage.2009.07.057
   Greimel E, 2010, J NEURAL TRANSM, V117, P781, DOI 10.1007/s00702-010-0404-9
   Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Hutman T, 2010, J CHILD PSYCHOL PSYC, V51, P1010, DOI 10.1111/j.1469-7610.2010.02270.x
   Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
   Keller K., 2011, J CHILD PSYCHOL PSYC, V53, P651, DOI DOI 10.1111/J.1469-7610.2011.02499.X
   Kobayashi C, 2008, SOC COGN AFFECT NEUR, V3, P62, DOI 10.1093/scan/nsm039
   Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
   Light SN, 2009, CHILD DEV, V80, P1210, DOI 10.1111/j.1467-8624.2009.01326.x
   Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
   Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
   Lou HC, 2004, P NATL ACAD SCI USA, V101, P6827, DOI 10.1073/pnas.0400049101
   Luna B, 2001, SCHIZOPHRENIA BULL, V27, P443
   Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036
   Moor BG, 2012, SOC COGN AFFECT NEUR, V7, P44, DOI 10.1093/scan/nsr020
   Pfeifer JH, 2007, J COGNITIVE NEUROSCI, V19, P1323, DOI 10.1162/jocn.2007.19.8.1323
   Pfeifer JH, 2008, NEUROIMAGE, V39, P2076, DOI 10.1016/j.neuroimage.2007.10.032
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   Ridderinkhof KR, 2004, SCIENCE, V306, P443, DOI 10.1126/science.1100301
   Scambler DJ, 2007, J AUTISM DEV DISORD, V37, P553, DOI 10.1007/s10803-006-0186-y
   Schulte-Ruther M., 2011, DNA SOCIAL COGNITION, P47
   Schulte-Ruther M, 2008, NEUROIMAGE, V42, P393, DOI 10.1016/j.neuroimage.2008.04.180
   Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
   Schulte-Ruther M, 2007, J COGNITIVE NEUROSCI, V19, P1354, DOI 10.1162/jocn.2007.19.8.1354
   Shattuck PT, 2007, J AUTISM DEV DISORD, V37, P1735, DOI 10.1007/s10803-006-0307-7
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
   STRAYER J, 1993, CHILD DEV, V64, P188, DOI 10.1111/j.1467-8624.1993.tb02903.x
   Tamm L, 2002, J AM ACAD CHILD PSY, V41, P1231, DOI 10.1097/00004583-200210000-00013
   Thompson RA, 1987, EMPATHY ITS DEV, P119
   Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
   Uddin LQ, 2005, NEUROIMAGE, V25, P926, DOI 10.1016/j.neuroimage.2004.12.018
   Vogeley K, 2003, TRENDS COGN SCI, V7, P38, DOI 10.1016/S1364-6613(02)00003-7
   Vogeley K, 2001, NEUROIMAGE, V14, P170, DOI 10.1006/nimg.2001.0789
   Wang AT, 2006, SOC COGN AFFECT NEUR, V1, P107, DOI 10.1093/scan/nsl018
   Wellman HM, 2004, CHILD DEV, V75, P523, DOI 10.1111/j.1467-8624.2004.00691.x
   White SJ, 2011, AUTISM RES, V4, P149, DOI 10.1002/aur.174
   Wicker B, 2003, NEURON, V40, P655, DOI 10.1016/S0896-6273(03)00679-2
   ZAHNWAXLER C, 1990, MOTIV EMOTION, V14, P107, DOI 10.1007/BF00991639
NR 77
TC 2
Z9 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2014
VL 9
IS 8
BP 1118
EP 1126
DI 10.1093/scan/nst088
PG 9
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AQ7IA
UT WOS:000342984900010
PM 23784073
ER

PT J
AU Fan, YT
   Chen, CY
   Chen, SC
   Decety, J
   Cheng, YW
AF Fan, Yang-Teng
   Chen, Chenyi
   Chen, Shih-Chuan
   Decety, Jean
   Cheng, Yawei
TI Empathic arousal and social understanding in individuals with autism:
   evidence from fMRI and ERP measurements
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorder (ASD); empathy; pressure pain thresholds (PPT);
   functional MRI (fMRI); electroencephalography/event-related potentials
   (EEG/ERP)
ID EVENT-RELATED POTENTIALS; MIRROR NEURON SYSTEM; SPECTRUM DISORDERS;
   ASPERGER-SYNDROME; FUNCTIONING AUTISM; EMOTIONAL EMPATHY; CINGULATE
   CORTEX; INSULAR CORTEX; PAIN; BRAIN
AB Lack of empathy is a hallmark of social impairments in individuals with autism spectrum disorder (ASD). However, the concept empathy encompasses several socio-emotional and behavioral components underpinned by interacting brain circuits. This study examined empathic arousal and social understanding in individuals with ASD and matched controls by combining pressure pain thresholds (PPT) with functional magnetic resonance imaging (study 1) and electroencephalography/event-related potentials and eye-tracking responses (study 2) to empathy-eliciting stimuli depicting physical bodily injuries. Results indicate that participants with ASD had lower PPT than controls. When viewing body parts being accidentally injured, increased hemodynamic responses in the somatosensory cortex (SI/SII) but decreased responses in the anterior mid-cingulate and anterior insula as well as heightened N2 but preserved late-positive potentials (LPP) were detected in ASD participants. When viewing a person intentionally hurting another, decreased hemodynamic responses in the medial prefrontal cortex and reduced LPP were observed in the ASD group. PPT was a mediator for the SI/SII response in predicting subjective unpleasantness ratings to others' pain. Both ASD and control groups had comparable mu suppression, indicative of typical sensorimotor resonance. The findings demonstrate that, in addition to reduced pain thresholds, individuals with ASD exhibit heightened empathic arousal but impaired social understanding when perceiving others' distress.
C1 [Fan, Yang-Teng; Chen, Chenyi; Chen, Shih-Chuan; Cheng, Yawei] Natl Yang Ming Univ, Inst Neurosci, Taipei 112, Taiwan.
   [Fan, Yang-Teng; Chen, Chenyi; Chen, Shih-Chuan; Cheng, Yawei] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan.
   [Decety, Jean] Univ Chicago, Dept Psychol, Chicago, IL 60637 USA.
   [Decety, Jean] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
   [Cheng, Yawei] Natl Yang Ming Univ Hosp, Dept Rehabil, Yilan, Taiwan.
RP Cheng, YW (reprint author), Natl Yang Ming Univ, Inst Neurosci, 155,Sec 2,St Linong, Taipei 112, Taiwan.
EM ywcheng2@ym.edu.tw
FU National Science Council [NSC 99-2314-B-010-037-MY3, NSC
   100-2628-H-010-001-MY3]; National Yang-Ming University Hospital [RD
   2011-005]; Health Department of Taipei City Government [10201-62-064];
   Ministry of Education (Aim for the Top University Plan); NSF
   [BCS-0718480]
FX The authors thank Dr. Yu-Yu Wu for helpful support on clinical
   assessments. The study was funded by National Science Council (NSC
   99-2314-B-010-037-MY3; NSC 100-2628-H-010-001-MY3), National Yang-Ming
   University Hospital (RD 2011-005), the Health Department of Taipei City
   Government (10201-62-064) and a grant from the Ministry of Education
   (Aim for the Top University Plan). Dr. Jean Decety was supported by an
   NSF grant (BCS-0718480).
CR Akitsuki Y, 2009, NEUROIMAGE, V47, P722, DOI 10.1016/j.neuroimage.2009.04.091
   Baird AD, 2011, SOC NEUROSCI-UK, V6, P327, DOI 10.1080/17470919.2010.547085
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S., 1997, HDB AUTISM PERVASIVE
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   Batson CD, 2009, SOCIAL NEUROSCIENCE OF EMPATHY, P3
   BIERI D, 1990, PAIN, V41, P139, DOI 10.1016/0304-3959(90)90018-9
   Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
   Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
   Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
   Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
   Cattaneo L, 2009, ARCH NEUROL-CHICAGO, V66, P557, DOI 10.1001/archneurol.2009.41
   Chen CY, 2012, SOC NEUROSCI-UK, V7, P578, DOI 10.1080/17470919.2012.686924
   Cheng Y, 2008, NEUROIMAGE, V40, P1833, DOI 10.1016/j.neuroimage.2008.01.064
   Cheng YW, 2012, DEV PSYCHOPATHOL, V24, P623, DOI 10.1017/S095457941200020X
   Craig AD, 2003, CURR OPIN NEUROBIOL, V13, P500, DOI 10.1016/S0959-4388(03)00090-4
   Craig KD, 2009, CAN PSYCHOL, V50, P22, DOI 10.1037/a0014772
   Critchley HD, 2000, J NEUROSCI, V20, P3033
   Crockett MJ, 2010, P NATL ACAD SCI USA, V107, P17433, DOI 10.1073/pnas.1009396107
   Cuthbert BN, 2000, BIOL PSYCHOL, V52, P95, DOI 10.1016/S0301-0511(99)00044-7
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
   Decety J, 2010, DEVELOPMENTAL SCI, V13, P886, DOI 10.1111/j.1467-7687.2009.00940.x
   Decety J, 2011, EMOT REV, V3, P92, DOI 10.1177/1754073910374662
   Decety J, 2012, DEV COGN NEUROS-NETH, V2, P1, DOI 10.1016/j.dcn.2011.05.003
   Decety J, 2008, NEUROPSYCHOLOGIA, V46, P2607, DOI 10.1016/j.neuropsychologia.2008.05.026
   Decety J., 2007, SOCIAL NEUROSCIENCE
   Decety J, 2009, BIOL PSYCHOL, V80, P203, DOI 10.1016/j.biopsycho.2008.09.004
   Dennis TA, 2009, J CHILD PSYCHOL PSYC, V50, P1373, DOI 10.1111/j.1469-7610.2009.02168.x
   Dinstein I, 2010, NEURON, V66, P461, DOI 10.1016/j.neuron.2010.03.034
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Fan Y, 2008, NEUROPSYCHOLOGIA, V46, P160, DOI 10.1016/j.neuropsychologia.2007.07.023
   Fan YT, 2010, J CHILD PSYCHOL PSYC, V51, P981, DOI 10.1111/j.1469-7610.2010.02269.x
   Frith U, 2005, CURR BIOL, V15, pR786, DOI 10.1016/j.cub.2005.09.033
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   GILLBERG C, 1985, DEV MED CHILD NEUROL, V27, P293
   GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x
   Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
   Gu XS, 2010, J NEUROSCI, V30, P3739, DOI 10.1523/JNEUROSCI.4844-09.2010
   Gu XS, 2012, BRAIN, V135, P2726, DOI 10.1093/brain/aws199
   Han SH, 2008, BRAIN RES, V1196, P85, DOI 10.1016/j.brainres.2007.12.062
   Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8
   Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724
   Hobson R. Peter, 1993, AUTISM DEV MIND
   Ibanez A, 2012, SOC NEUROSCI-UK, V7, P632, DOI 10.1080/17470919.2012.691078
   Keysers C., 2011, OXFORD HDB SOCIAL NE
   Kleinhans NM, 2009, AM J PSYCHIAT, V166, P467, DOI 10.1176/appi.ajp.2008.07101681
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kurth F, 2010, BRAIN STRUCT FUNCT, V214, P519, DOI 10.1007/s00429-010-0255-z
   Lamm C, 2011, NEUROIMAGE, V54, P2492, DOI 10.1016/j.neuroimage.2010.10.014
   Li W, 2010, NEUROSCI LETT, V469, P328, DOI 10.1016/j.neulet.2009.12.021
   Lockwood P.L., 2013, CURR BIOL, V23, P1
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Magnee MJCM, 2007, J CHILD PSYCHOL PSYC, V48, P1122, DOI 10.1111/j.1469-7610.2007.01779.x
   Marsh AA, 2013, J CHILD PSYCHOL PSYC, V54, P900, DOI 10.1111/jcpp.12063
   McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
   Mella N, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00501
   Menon V, 2010, BRAIN STRUCT FUNCT, V214, P655, DOI 10.1007/s00429-010-0262-0
   Militerni R., 2000, J HEADACHE PAIN, V1, P53, DOI 10.1007/s101940050011
   Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006
   Mottron L., 2001, DEV AUTISM PERSPECTI
   Nader R, 2004, CLIN J PAIN, V20, P88, DOI 10.1097/00002508-200403000-00005
   Nieuwenhuys R, 2012, PROG BRAIN RES, V195, P123, DOI 10.1016/B978-0-444-53860-4.00007-6
   Olofsson JK, 2007, BIOL PSYCHOL, V75, P101, DOI 10.1016/j.biopsycho.2006.12.006
   Olofsson JK, 2008, BIOL PSYCHOL, V77, P247, DOI 10.1016/j.biopsycho.2007.11.006
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
   Pelphrey KA, 2008, ANN NY ACAD SCI, V1145, P283, DOI 10.1196/annals.1416.007
   Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
   Perry A, 2010, COGN AFFECT BEHAV NE, V10, P493, DOI 10.3758/CABN.10.4.493
   Raymaekers R, 2009, BRAIN RES, V1304, P113, DOI 10.1016/j.brainres.2009.09.068
   Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
   Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
   Shackman AJ, 2011, NAT REV NEUROSCI, V12, P154, DOI 10.1038/nrn2994
   Shamay-Tsoory S., 2009, SOCIAL NEUROSCIENCE
   Smith A, 2009, PSYCHOL REC, V59, P489
   Tordjman S, 1997, J CHILD PSYCHOL PSYC, V38, P705, DOI 10.1111/j.1469-7610.1997.tb01697.x
   Wager TD, 2008, NEURON, V59, P1037, DOI 10.1016/j.neuron.2008.09.006
   Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
   Winkielman P, 2009, EMOT REV, V1, P178, DOI 10.1177/1754073908100442
   Zaki J, 2012, SO NEUROSCI SER, P207
   Zhu XZ, 2007, COMPR PSYCHIAT, V48, P489, DOI 10.1016/j.comppsch.2007.04.007
NR 84
TC 5
Z9 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2014
VL 9
IS 8
BP 1203
EP 1213
DI 10.1093/scan/nst101
PG 11
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AQ7IA
UT WOS:000342984900020
PM 23929944
ER

PT J
AU Kroger, A
   Bletsch, A
   Krick, C
   Siniatchkin, M
   Jarczok, TA
   Freitag, CM
   Bender, S
AF Kroeger, Anne
   Bletsch, Anke
   Krick, Christoph
   Siniatchkin, Michael
   Jarczok, Tomasz A.
   Freitag, Christine M.
   Bender, Stephan
TI Visual event-related potentials to biological motion stimuli in autism
   spectrum disorders
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE event-related-potentials; motion perception; P100; N200;
   hemisphere-asymmetry
ID SUPERIOR TEMPORAL SULCUS; EVOKED-POTENTIALS; DEVELOPMENTAL-CHANGES;
   COHERENT MOTION; YOUNG-CHILDREN; ATYPICAL FACE; ERP EVIDENCE;
   TIME-COURSE; PERCEPTION; LANGUAGE
AB Atypical visual processing of biological motion contributes to social impairments in autism spectrum disorders (ASD). However, the exact temporal sequence of deficits of cortical biological motion processing in ASD has not been studied to date. We used 64-channel electroencephalography to study event-related potentials associated with human motion perception in 17 children and adolescents with ASD and 21 typical controls. A spatio-temporal source analysis was performed to assess the brain structures involved in these processes. We expected altered activity already during early stimulus processing and reduced activity during subsequent biological motion specific processes in ASD. In response to both, random and biological motion, the P100 amplitude was decreased suggesting unspecific deficits in visual processing, and the occipito-temporal N200 showed atypical lateralization in ASD suggesting altered hemispheric specialization. A slow positive deflection after 400 ms, reflecting top-down processes, and human motion-specific dipole activation differed slightly between groups, with reduced and more diffuse activation in the ASD-group. The latter could be an indicator of a disrupted neuronal network for biological motion processing in ADS. Furthermore, early visual processing (P100) seems to be correlated to biological motion-specific activation. This emphasizes the relevance of early sensory processing for higher order processing deficits in ASD.
C1 [Kroeger, Anne; Bletsch, Anke; Siniatchkin, Michael; Jarczok, Tomasz A.; Freitag, Christine M.; Bender, Stephan] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
   [Krick, Christoph] Saarland Univ Hosp, Dept Neuroradiol, D-66424 Homburg, Germany.
   [Bender, Stephan] Tech Univ Dresden, Dept Child & Adolescent Psychiat & Psychotherapy, D-01307 Dresden, Germany.
RP Kroger, A (reprint author), Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, Deutschordenstr 50, D-60528 Frankfurt, Germany.
EM Anne.Kroeger@kgu.de
FU foundation of Marie Christine Held and Erika Hecker; German Research
   foundation 'Deutsche Forschungsgemeinschaft' [FR2069/2-1]; LOEWE-Program
   'Neuronal Coordination Research Focus Frankfurt' (NeFF)
FX First, we thank all families, who supported our work by participating in
   our study. We also thank Jennifer Bohm and Katharina Hof for assistance
   with the data collection, Benjamin Teufert for data calculations and our
   clinical colleagues for helping us with recruiting participants. This
   work was supported by the foundation of Marie Christine Held and Erika
   Hecker to A.K., the German Research foundation 'Deutsche
   Forschungsgemeinschaft' to C.M.F. (FR2069/2-1), and by the LOEWE-Program
   'Neuronal Coordination Research Focus Frankfurt' (NeFF) to C.M.F. and
   S.B.
CR Allison T, 1999, CEREB CORTEX, V9, P415, DOI 10.1093/cercor/9.5.415
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x
   Annaz D, 2012, J AUTISM DEV DISORD, V42, P401, DOI 10.1007/s10803-011-1256-3
   Arbeitsgruppe Kinder Jugendlichen- und Familiendiagnostik, 1998, CBCL 4 18 ELTERNFRAG
   Baker KS, 2011, NEUROPSYCHOLOGIA, V49, P3303, DOI 10.1016/j.neuropsychologia.2011.08.003
   Baker KS, 2012, NEUROPSYCHOLOGIA, V50, P715, DOI 10.1016/j.neuropsychologia.2011.12.026
   Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150
   Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
   Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
   Boddaert N, 2004, AM J PSYCHIAT, V161, P2117, DOI 10.1176/appi.ajp.161.11.2117
   Bolte S, 2006, DIAGNOSTISCHES INTER
   Brieber S, 2010, NEUROPSYCHOLOGIA, V48, P1644, DOI 10.1016/j.neuropsychologia.2010.02.007
   Bulheller S., 2003, RAVENSS PROGR MATRIC
   Bulheller S., 2002, COLOURED PROGR MATRI
   Cook J, 2009, NEUROPSYCHOLOGIA, V47, P3275, DOI 10.1016/j.neuropsychologia.2009.07.010
   Cunnington R, 2003, NEUROIMAGE, V20, P404, DOI 10.1016/S1053-8119(03)00291-X
   De Fosse L, 2004, ANN NEUROL, V56, P757, DOI 10.1002/ana.20275
   Eyler LT, 2012, BRAIN, V135, P949, DOI 10.1093/brain/awr364
   Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Gage NM, 2009, J NEURODEV DISORD, V1, P205, DOI 10.1007/s11689-009-9010-2
   Glasel H, 2011, NEUROIMAGE, V58, P716, DOI 10.1016/j.neuroimage.2011.06.016
   Grefkes C, 2005, J ANAT, V207, P3, DOI 10.1111/j.1469-7580.2005.00426.x
   Grossmann T, 2007, EUR J NEUROSCI, V25, P909, DOI 10.1111/j.1460-9568.2007.05379.x
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Heimann M, 2006, INFANT CHILD DEV, V15, P233, DOI 10.1002/icd.462
   Hein G, 2008, J COGNITIVE NEUROSCI, V20, P2125, DOI 10.1162/jocn.2008.20148
   Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002
   Hirai M, 2008, J VISION, V8, DOI 10.1167/8.16.2
   Hirai M, 2009, NEUROSCIENCE, V161, P311, DOI 10.1016/j.neuroscience.2009.03.026
   Hirai M, 2003, NEUROSCI LETT, V344, P41, DOI 10.1016/S0304-3940(03)00413-0
   Hoffmann M, 1999, VISION RES, V39, P437, DOI 10.1016/S0042-6989(98)00186-2
   JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378
   Jokisch D, 2005, BEHAV BRAIN RES, V157, P195, DOI 10.1016/j.bbr.2004.06.025
   Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209
   Kaiser MD, 2012, DEV COGN NEUROS-NETH, V2, P25, DOI 10.1016/j.dcn.2011.05.005
   Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
   Kaiser MD, 2010, AUTISM RES, V3, P191, DOI 10.1002/aur.137
   Kasprian G, 2011, CEREB CORTEX, V21, P1076, DOI 10.1093/cercor/bhq179
   Keita L, 2011, BIOL PSYCHIAT, V70, P806, DOI 10.1016/j.biopsych.2011.07.031
   Kleinhans NM, 2008, BRAIN RES, V1221, P115, DOI 10.1016/j.brainres.2008.04.080
   Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
   Koldewyn K, 2011, DEVELOPMENTAL SCI, V14, P1075, DOI 10.1111/j.1467-7687.2011.01058.x
   Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272
   Krakowski AI, 2011, NEUROIMAGE, V56, P373, DOI 10.1016/j.neuroimage.2011.01.058
   KUBOVA Z, 1995, VISION RES, V35, P197, DOI 10.1016/0042-6989(94)00138-C
   McCleery JP, 2009, BIOL PSYCHIAT, V66, P950, DOI 10.1016/j.biopsych.2009.07.031
   McCleery JP, 2007, BIOL PSYCHIAT, V62, P1007, DOI 10.1016/j.biopsych.2007.02.009
   McKay LS, 2012, NEUROIMAGE, V59, P1524, DOI 10.1016/j.neuroimage.2011.08.033
   McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
   Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026
   Nackaerts E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044473
   Niedeggen M, 1999, COGNITIVE BRAIN RES, V8, P95, DOI 10.1016/S0926-6410(99)00009-9
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Pavlova MA, 2012, CEREB CORTEX, V22, P981, DOI 10.1093/cercor/bhr156
   Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
   Price KJ, 2012, RES AUTISM SPECT DIS, V6, P391, DOI 10.1016/j.rasd.2011.06.013
   Prieto EA, 2007, NEUROIMAGE, V37, P1384, DOI 10.1016/j.neuroimage.2007.03.080
   Ruhl D., 2004, GERMAN VERSION AUTIS
   Rutherford MD, 2012, J AUTISM DEV DISORD, V42, P557, DOI 10.1007/s10803-011-1267-0
   Saygin AP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013491
   Schendan HE, 2007, J COGNITIVE NEUROSCI, V19, P734, DOI 10.1162/jocn.2007.19.5.734
   Schneider S, 2009, DIAGNOSTISCHES INTER
   Simion F, 2008, P NATL ACAD SCI USA, V105, P809, DOI 10.1073/pnas.0707021105
   STANDAGE GP, 1983, BRAIN RES, V262, P288, DOI 10.1016/0006-8993(83)91020-X
   Stone WL, 2001, AUTISM, V5, P341, DOI 10.1177/1362361301005004002
   Taylor MJ, 1999, CLIN NEUROPHYSIOL, V110, P910, DOI 10.1016/S1388-2457(99)00006-1
   Taylor MJ, 1995, J PSYCHOPHYSIOL, V9, P283
   Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
   Troje NF, 2002, J VISION, V2, P371, DOI 10.1167/2.5.2
   Vallortigara G, 2005, BEHAV BRAIN SCI, V28, P575, DOI 10.1017/S0140525X05000105
   Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321
   Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
   Wagner JB, 2013, J AUTISM DEV DISORD, V43, P188, DOI 10.1007/s10803-012-1565-1
   Wandell BA, 2007, NEURON, V56, P366, DOI 10.1016/j.neuron.2007.10.012
   Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 79
TC 3
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2014
VL 9
IS 8
BP 1214
EP 1222
DI 10.1093/scan/nst103
PG 9
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA AQ7IA
UT WOS:000342984900021
PM 23887808
ER

PT J
AU Hebron, J
   Humphrey, N
AF Hebron, Judith
   Humphrey, Neil
TI Exposure to bullying among students with autism spectrum conditions: A
   multi-informant analysis of risk and protective factors
SO AUTISM
LA English
DT Article
DE bullying; protection; risk; school; victimisation
ID HIGH-FUNCTIONING AUTISM; SCHOOL-AGED CHILDREN; PARENTAL INVOLVEMENT;
   ACADEMIC-ACHIEVEMENT; PEER RELATIONSHIPS; ASPERGER-SYNDROME; ADOLESCENT
   BOYS; VICTIMIZATION; DISORDERS; PREVALENCE
AB Research has consistently shown that children and young people with autism spectrum conditions are more likely to be bullied than those with other or no special educational needs. The aim of this study was to examine risk and protective factors that could help to explain variation in exposure to bullying within this group. A sample of 722 teachers and 119 parents reported on their child's experience of being bullied. This response variable was regressed onto a range of explanatory variables representing individual and contextual factors. The teacher-and parent-rated regression models were statistically significant, explaining large proportions of variance in exposure to bullying. Behaviour difficulties and increased age were associated with bullying in both models. Positive relationships and attending a special school were associated with a decrease in bullying in the teacher model, with use of public/school transport predicting an increase. In the parent model, special educational needs provision at School Action Plus (as opposed to having a Statement of Special Educational Needs) was a significant risk factor, and higher levels of parental engagement and confidence were associated with reductions in bullying. These findings are discussed in relation to the autism spectrum conditions literature, and opportunities for intervention are considered.
C1 [Hebron, Judith; Humphrey, Neil] Univ Manchester, Manchester M13 9PL, Lancs, England.
RP Hebron, J (reprint author), Univ Manchester, Sch Educ, Oxford Rd, Manchester M13 9PL, Lancs, England.
EM judith.hebron@manchester.ac.uk
CR Abou-Ezzeddine T, 2007, SOC DEV, V16, P106, DOI 10.1111/j.1467-9507.2007.00374.x
   ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baron-Cohen S, 2012, ASD VS ASC IS ONE SM
   Bauminger N, 2010, J AUTISM DEV DISORD, V40, P751, DOI 10.1007/s10803-009-0928-8
   Bauminger N, 2008, J ABNORM CHILD PSYCH, V36, P135, DOI 10.1007/s10802-007-9156-x
   Bauminger N, 2003, AUTISM, V7, P81, DOI 10.1177/1362361303007001007
   Bishop DVM, 2008, DEV MED CHILD NEUROL, V50, P341, DOI 10.1111/j.1469-8749.2008.02057.x
   Bond L, 2007, J SCHOOL HEALTH, V77, P75, DOI 10.1111/j.1746-1561.2007.00170.x
   Bowen R, 2010, SURVEY PREVALENCE IN
   Brock SE, 2006, J SCH VIOLENCE, V5, P3, DOI 10.1300/J202v05n03_02
   Bronfenbrenner U., 1979, ECOLOGY HUMAN DEV EX
   Byrne B, 1993, COPING BULLYING SCH
   Cappadocia MC, 2012, J AUTISM DEV DISORD, V42, P266, DOI 10.1007/s10803-011-1241-x
   Card NA, 2008, SCH VIOLENCE PRIMARY, P125, DOI 10.1007/978-0-387-77119-9_7
   Card NA, 2007, SOC DEV, V16, P479, DOI 10.1111/j.1467-9507.2007.00394.x
   Carrington S, 2001, AUTISM, V5, P37, DOI 10.1177/1362361301005001004
   Carter Susan, 2009, Issues Compr Pediatr Nurs, V32, P145, DOI 10.1080/01460860903062782
   Chamberlain T, 2010, TELLUS4 NATL REPORT
   Cigman R., 2007, INCLUDED EXCLUDED CH
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Cook CR, 2010, SCHOOL PSYCHOL QUART, V25, P65, DOI 10.1037/a0020149
   Department for Education, 2010, CHILDR SPEC ED NEEDS
   Department for Education and Skills, 2001, SPEC ED NEEDS COD PR
   Domitrovich CE, 2010, PSYCHOL SCHOOLS, V47, P71, DOI 10.1002/pits.20452
   Due P, 2005, EUR J PUBLIC HEALTH, V15, P128, DOI 10.1093/eurpub/cki105
   Dulmus C. N., 2004, STRESS TRAUMA CRISIS, V7, P1, DOI DOI 10.1080/15434610490281093
   Epstein JL, 2002, J EDUC RES, V95, P308
   Fan XT, 2001, EDUC PSYCHOL REV, V13, P1, DOI 10.1023/A:1009048817385
   Feinberg ME, 2007, J ADOLESCENT HEALTH, V40, P506, DOI 10.1016/j.jadohealth.2006.09.002
   Ferguson C. J., 2007, CRIMINAL JUSTICE REV, V32, P401, DOI DOI 10.1177/0734016807311712
   Frankel FD, 2011, J CHILD PSYCHOL PSYC, V52, P571, DOI 10.1111/j.1469-7610.2010.02318.x
   Frederickson N., 2009, SPECIAL ED NEEDS INC
   Garner PW, 2010, J COMMUNITY APPL SOC, V20, P480, DOI 10.1002/casp.1057
   Gewirtz AH, 2007, J FAM VIOLENCE, V22, P151, DOI 10.1007/s10896-007-9065-3
   Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530
   Green R., 2010, CHARACTERISTICS BULL
   Griffin RS, 2004, AGGRESS VIOLENT BEH, V9, P379, DOI 10.1016/S1359-1789(03)00033-8
   Hampel P, 2009, SCHOOL PSYCHOL INT, V30, P474, DOI 10.1177/0143034309107066
   Harris A, 2008, EDUC RES-UK, V50, P277, DOI 10.1080/00131880802309424
   Hawker DSJ, 2000, J CHILD PSYCHOL PSYC, V41, P441, DOI 10.1017/S0021963099005545
   Hobbs G, 2010, BRIT EDUC RES J, V36, P673, DOI 10.1080/01411920903083111
   Horowitz JA, 2004, J AM PSYCHIAT NURSES, V10, P165, DOI DOI 10.1177/1078390304267862
   Humphrey N, 2011, AUTISM, V15, P397, DOI 10.1177/1362361310387804
   Humphrey N., 2011, ACHIEVEMENT ALL NATL
   Humphrey N, BULLYING CH IN PRESS
   Humphrey N., 2010, ACHIEVEMENT ALL NATL
   Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
   Humphrey N., 2010, EUROPEAN J SPECIAL N, V25, P77, DOI DOI 10.1080/08856250903450855
   Humphrey N, 2010, J RES SPECIAL ED NEE, V10, P82, DOI DOI 10.1111/J.1471-3802.2010.01146.X
   Jeynes WH, 2005, URBAN EDUC, V40, P237, DOI 10.1177/0042085905274540
   Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
   Klomek AB, 2007, J AM ACAD CHILD PSY, V46, P40, DOI 10.1097/01.chi.0000242237.84925.18
   Lasgaard M, 2010, J AUTISM DEV DISORD, V40, P218, DOI 10.1007/s10803-009-0851-z
   Little Liza, 2002, Issues Compr Pediatr Nurs, V25, P43, DOI 10.1080/014608602753504847
   Locke J., 2010, J RES SPECIAL ED NEE, V10, P74, DOI DOI 10.1111/J.1471-3802.2010.01148.X
   Macintosh K, 2006, J AUTISM DEV DISORD, V36, P1065, DOI 10.1007/s10803-006-0139-5
   Masten AS, 2010, DEV PSYCHOPATHOL, V22, P491, DOI 10.1017/S0954579410000222
   McLaughlin C., 2010, RESPONDING BULLYING
   McMahon EM, 2010, SOC SCI MED, V71, P1300, DOI 10.1016/j.socscimed.2010.06.034
   McNeely CA, 2002, J SCHOOL HEALTH, V72, P138
   Merrell KW, 2008, SCHOOL PSYCHOL QUART, V23, P26, DOI 10.1037/1045-3830.23.1.26
   Moore C., 2007, INCLUDED EXCLUDED CH, P34
   Nabuzoka D., 2003, ED PSYCHOL, V23, P307, DOI DOI 10.1080/0144341032000060147
   Nansel TR, 2001, JAMA-J AM MED ASSOC, V285, P2094, DOI 10.1001/jama.285.16.2094
   Olweus D, 2013, ANNU REV CLIN PSYCHO, V9, P751, DOI 10.1146/annurev-clinpsy-050212-185516
   Olweus D., 1993, BULLYING SCH WHAT WE
   Olweus D., 1978, AGGRESSION SCH BULLI
   Raskauskas J, 2008, J SCH VIOLENCE, V4, P93
   Ravet J, 2011, INT J INCLUSIVE EDUC, V15, P667, DOI 10.1080/13603110903294347
   Reid B, 2006, B IS BULLIED
   Reid B, 2011, GREAT EXPECTATIONS
   Richard JF, 2012, SCHOOL PSYCHOL INT, V33, P263, DOI 10.1177/0143034311415906
   Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1127
   Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   SINGH K, 1995, SCHOOL PSYCHOL REV, V24, P299
   Smith JD, 2004, SCHOOL PSYCHOL REV, V33, P547
   Sofronoff K, 2011, AUTISM, V15, P355, DOI 10.1177/1362361310365070
   Sterzing PR, 2012, ARCH PEDIAT ADOL MED, V166, P1058, DOI 10.1001/archpediatrics.2012.790
   SuiChu EH, 1996, SOCIOL EDUC, V69, P126, DOI 10.2307/2112802
   Swearer SM, 2010, EDUC RESEARCHER, V39, P38, DOI 10.3102/0013189X09357622
   Terwee CB, 2007, J CLIN EPIDEMIOL, V60, P34, DOI 10.1016/j.jclinepi.2006.03.012
   Turner HA, 2006, SOC SCI MED, V62, P13, DOI 10.1016/j.socscimed.2005.05.030
   van Roekel E, 2010, J AUTISM DEV DISORD, V40, P63, DOI 10.1007/s10803-009-0832-2
   Wainscot J. J., 2008, INT J PSYCHOL PSYCHO, V8, P25
   Whitted K. S., 2005, CHILDREN SCH, V27, P167, DOI DOI 10.1037/0022-0663.95.3.570
NR 87
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 618
EP 630
DI 10.1177/1362361313495965
PG 13
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900001
PM 23886576
ER

PT J
AU Schubart, JR
   Camacho, F
   Leslie, D
AF Schubart, Jane R.
   Camacho, Fabian
   Leslie, Douglas
TI Psychotropic medication trends among children and adolescents with
   autism spectrum disorder in the Medicaid program
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; children and adolescents; Medicaid;
   psychotropic medications
ID PREVALENCE; PATTERNS; MANAGEMENT; DRUGS
AB This study characterized psychotropic medication use among Medicaid-enrolled children and adolescents with autism spectrum disorders by examining trends over time, including length of treatment and polypharmacy using 4 years of administrative claims data from 41 state Medicaid programs (2000-2003). The data set included nearly 3 million children and adolescents who were 17 years or younger. Approximately, 65% of children with autism spectrum disorder received a psychotropic medication. The results indicate an increasing overall trend in the use of psychotropic drugs among children and adolescents with autism spectrum disorders. Among the different classes of psychotropic drugs, antipsychotics were the most common. Increasing trends in polypharmacy were observed both within and between medication classes.
C1 [Schubart, Jane R.; Camacho, Fabian; Leslie, Douglas] Penn State Univ, Hershey, PA 17033 USA.
RP Schubart, JR (reprint author), Penn State Univ, Coll Med, Dept Surg Med & Publ Hlth Sci, 500 Univ Dr, Hershey, PA 17033 USA.
EM jschubart@hmc.psu.edu
CR Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
   AMAN MG, 1995, J AM ACAD CHILD PSY, V34, P1672, DOI 10.1097/00004583-199512000-00018
   American Medical Association, 2005, CLIN MOD 2005
   Centers for Disease Control and Prevention (CDC), 2012, AUT DEV DIS MON ADDM
   Ching H, 2012, COCHRANE DB SYST REV, V5
   Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
   Gerhard T, 2009, J CLIN PSYCHOPHARM, V29, P307, DOI 10.1097/JCP.0b013e3181a20c8a
   Gringras P, 2000, AUTISM, V4, P229, DOI 10.1177/1362361300004003002
   Khanna R, 2013, J INTELL DISABIL RES, V57, P161, DOI 10.1111/j.1365-2788.2012.01563.x
   Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
   Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
   Ming X, 2008, BRAIN DEV-JPN, V30, P454, DOI 10.1016/j.braindev.2007.12.007
   Morgan S, 2007, BRIT MED J, V334, P1069, DOI 10.1136/bmj.39216.583333.80
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Posey DJ, 2008, J CLIN INVEST, V118, P6, DOI 10.1172/JCI32483
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1
   Rubin DM, 2009, PEDIATRICS, V124, pE305, DOI 10.1542/peds.2008-3713
   Scahill L, 2009, CNS DRUGS, V23, P43, DOI 10.2165/00023210-200923000-00006
   Towbin KE, 2003, CHILD ADOL PSYCH CL, V12, P23, DOI 10.1016/S1056-4993(02)00049-4
   Wang L, 2010, J AM ACAD CHILD PSY, V49, P1165, DOI 10.1016/j.jaac.2010.08.003
   Wilens TE, 2012, J AM ACAD CHILD PSY, V51, P74, DOI 10.1016/j.jaac.2011.10.012
NR 22
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 631
EP 637
DI 10.1177/1362361313497537
PG 7
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900002
PM 24165274
ER

PT J
AU Panerai, S
   Tasca, D
   Lanuzza, B
   Trubia, G
   Ferri, R
   Musso, S
   Alagona, G
   Di Guardo, G
   Barone, C
   Gaglione, MP
   Elia, M
AF Panerai, Simonetta
   Tasca, Domenica
   Lanuzza, Bartolo
   Trubia, Grazia
   Ferri, Raffaele
   Musso, Sabrina
   Alagona, Giovanna
   Di Guardo, Giuseppe
   Barone, Concetta
   Gaglione, Maria P.
   Elia, Maurizio
TI Effects of repetitive transcranial magnetic stimulation in performing
   eye-hand integration tasks: Four preliminary studies with children
   showing low-functioning autism
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; premotor cortex; rehabilitation; transcranial
   magnetic stimulation
ID SPECTRUM DISORDERS; TOOL USE; MOTOR; ATTENTION; CORTEX; BRAIN;
   INTERFERENCE; PREVALENCE; DEFICITS
AB This report, based on four studies with children with low-functioning autism, aimed at evaluating the effects of repetitive transcranial magnetic stimulation delivered on the left and right premotor cortices on eye-hand integration tasks; defining the long-lasting effects of high-frequency repetitive transcranial magnetic stimulation; and investigating the real efficacy of high-frequency repetitive transcranial magnetic stimulation by comparing three kinds of treatments (high-frequency repetitive transcranial magnetic stimulation, a traditional eye-hand integration training, and both treatments combined). Results showed a significant increase in eye-hand performances only when high-frequency repetitive transcranial magnetic stimulation was delivered on the left premotor cortex; a persistent improvement up to 1 h after the end of the stimulation; better outcomes in the treatment combining high-frequency repetitive transcranial magnetic stimulation and eye-hand integration training. Based on these preliminary findings, further evaluations on the usefulness of high-frequency repetitive transcranial magnetic stimulation in rehabilitation of children with autism are strongly recommended.
C1 [Panerai, Simonetta; Tasca, Domenica; Lanuzza, Bartolo; Trubia, Grazia; Ferri, Raffaele; Musso, Sabrina; Di Guardo, Giuseppe; Barone, Concetta; Gaglione, Maria P.; Elia, Maurizio] IRCCS Assoc Oasi Maria SS, Troina, EN, Italy.
   [Alagona, Giovanna] Azienda Osped Emergenza Cannizzaro, Catania, Italy.
RP Panerai, S (reprint author), Oasi Inst Res Mental Retardat & Brain Aging, Via Conte Ruggero 73, I-94018 Troina, EN, Italy.
EM spanerai@oasi.en.it
CR American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
   Baruth JM, 2010, J NEUROTHERAPY, V14, P179, DOI DOI 10.1080/10874208.2010.501500
   Bloch Y, 2010, WORLD J BIOL PSYCHIA, V11, P755, DOI 10.3109/15622975.2010.484466
   Boyd LA, 2009, BMC NEUROSCI, V7, P10
   Demirtas-Tatlidede A, 2013, NEUROPHARMACOLOGY, V64, P566, DOI 10.1016/j.neuropharm.2012.06.020
   Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Enticott PG, 2010, DEV MED CHILD NEUROL, V52, P179
   Fink GR, 1997, J NEUROPHYSIOL, V77, P2164
   Frey SH, 2008, PHILOS T R SOC B, V363, P1951, DOI 10.1098/rstb.2008.0008
   Frey SH, 2007, CORTEX, V43, P368, DOI 10.1016/S0010-9452(08)70462-3
   Glants SA, 2005, PRIMER BIOSTATISTICS
   Goldstein G, 2001, J AUTISM DEV DISORD, V31, P433, DOI 10.1023/A:1010620820786
   Kern JK, 2007, AUTISM, V11, P123, DOI 10.1177/1362361307075702
   Kraijer D, 2000, J AUTISM DEV DISORD, V30, P39, DOI 10.1023/A:1005460027636
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Mager R F, 1962, PREPARING INSTRUCTIO
   Mesibov G., 2004, TEACCH APPROACH AUTI
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   Muller RA, 2001, BIOL PSYCHIAT, V49, P665, DOI 10.1016/S0006-3223(00)01004-0
   Murray D, 2005, AUTISM, V9, P139, DOI 10.1177/1362361305051398
   Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
   Panerai S, 2011, AUTISMO DISTURBI SVI, V9, P93
   Provost Beth, 2007, Phys Occup Ther Pediatr, V27, P21, DOI 10.1300/J006v27n03_03
   Rossi S, 2001, NAT NEUROSCI, V4, P948, DOI 10.1038/nn0901-948
   Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
   ROSSINI PM, 1994, ELECTROEN CLIN NEURO, V91, P79, DOI 10.1016/0013-4694(94)90029-9
   Rushworth MFS, 2003, NEUROIMAGE S1, V20, P89, DOI DOI 10.1016/J.NEUROIMAGE.2003.09.011
   Schluter ND, 1998, BRAIN, V121, P785, DOI 10.1093/brain/121.5.785
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Schopler E., 1990, INDIVIDUALIZED ASSES, VI
   Schubotz RI, 2003, NEUROIMAGE S1, V20, P20
   Sokhadze EM, 2009, J AUTISM DEV DISORD, V39, P619, DOI 10.1007/s10803-008-0662-7
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Tsai SJ, 2005, MED HYPOTHESES, V64, P1070, DOI 10.1016/j.mehy.2004.11.025
   Vanvuchelen M, 2007, AUTISM, V11, P225, DOI 10.1177/1362361307076846
   Wassermann EM, 1998, EVOKED POTENTIAL, V108, P1, DOI 10.1016/S0168-5597(97)00096-8
NR 37
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 638
EP 650
DI 10.1177/1362361313495717
PG 13
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900003
PM 24113340
ER

PT J
AU Cutress, AL
   Muncer, SJ
AF Cutress, Anna L.
   Muncer, Steven J.
TI Parents' views of the National Autistic Society's EarlyBird Plus
   Programme
SO AUTISM
LA English
DT Article
DE autism; EarlyBird Plus; parent training programme; post-diagnostic
   support; psychoeducation
ID PRESCHOOL-CHILDREN; SPECTRUM DISORDER; DOWN-SYNDROME; INTERVENTION;
   DIAGNOSIS; MOTHERS
AB Parent training interventions are recommended for parents soon after their child's autism spectrum condition diagnosis with the aim of improving parents' psychological well-being and coping, as well as the child's behaviour. This report explores parents' views of the EarlyBird Plus Programme through data collected routinely in the post-programme questionnaire. Participants' reported increased understanding of autism and improvements in their communication with their child and their ability to manage their child's behaviour. Parents appeared to value the opportunity to meet with other parents, and the programme seemed acceptable to the majority of parents who attended.
C1 [Cutress, Anna L.; Muncer, Steven J.] Univ Teesside, Middlesbrough TS1 3BA, Cleveland, England.
RP Cutress, AL (reprint author), Univ Teesside, Sch Hlth & Social Care, Clin Psychol Programme, Middlesbrough TS1 3BA, Cleveland, England.
EM k0106145@tees.ac.uk
CR Boyd B. A., 2002, FOCUS AUTISM OTHER D, V17, P208, DOI DOI 10.1177/10883576020170040301
   Braiden H, 2010, CHILD CARE PRACT, V16, P377
   BRISTOL MM, 1987, J AUTISM DEV DISORD, V17, P469, DOI 10.1007/BF01486964
   Clubb M, 2012, GOOD AUTISM PRACTICE, V13, P69
   Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
   Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
   Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
   Engwall P, 2003, GOOD AUTISM PRACTICE, V4, P13
   Hardy S, 1999, THESIS U TEESSIDE
   Keenan M, 2010, J APPL RES INTELLECT, V23, P390, DOI 10.1111/j.1468-3148.2010.00555.x
   Mansell W, 2004, AUTISM, V8, P387, DOI 10.1177/1362361304045213
   Morgan J, 2002, CHILD FAMILY SOCIAL, V7, P219, DOI DOI 10.1046/J.1365-2206.2002.00242.X
   National Autistic Society, 2010, EARLYBIRD PLUS PROGR
   National Autistic Society, 2011, EARLYBIRD PLUS PROGR
   National Initiative for Autism: Screening and Assessment (NIASA), 2003, NAT AUT PLAN CHILDR
   National Institute for Health and Clinical Excellence (NICE), 2006, COND DIS CHILDR PAR
   Pillay Mini, 2011, Clin Child Psychol Psychiatry, V16, P5, DOI 10.1177/1359104509340945
   Pisula E, 2011, COMPREHENSIVE BOOK A, P88
   Shields J, 2001, AUTISM, V5, P49, DOI 10.1177/1362361301005001005
   Siklos S, 2006, J AUTISM DEV DISORD, V36, P921, DOI 10.1007/s10803-006-0129-7
   Silvey S, 2009, BENEFITS EARLYBIRD P
   Sofronoff K, 2002, AUTISM, V6, P271, DOI 10.1177/1362361302006003005
   Solomon R, 2007, AUTISM, V11, P205, DOI 10.1177/1362361307076842
   Todd S, 2010, CHILD ADOL MENT H-UK, V15, P171, DOI 10.1111/j.1475-3588.2009.00553.x
NR 24
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 651
EP 657
DI 10.1177/1362361313495718
PG 7
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900004
PM 24104516
ER

PT J
AU Warreyn, P
   Roeyers, H
AF Warreyn, Petra
   Roeyers, Herbert
TI See what I see, do as I do: Promoting joint attention and imitation in
   preschoolers with autism spectrum disorder
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; imitation; intervention; joint attention;
   preschoolers; rehabilitation
ID OF-THE-LITERATURE; YOUNG-CHILDREN; PRETEND PLAY;
   NONVERBAL-COMMUNICATION; RECIPROCAL IMITATION; EARLY INTERVENTION;
   SOCIAL COMPETENCE; VISUAL-ATTENTION; DOWN-SYNDROME; HUMAN INFANTS
AB Since imitation and joint attention are both important abilities for young children and since children with autism spectrum disorder show a range of problems in these domains, imitation and joint attention are important targets for intervention. In this study, we examined the possibility of promoting imitation and joint attention by means of a training programme specifically designed for low-intensity, non-residential treatment. Two matched groups of 18 children each participated in the study. The experimental group, receiving the training programme, improved significantly more on joint attention than the group receiving only treatment as usual. Only the experimental group obtained a significantly higher imitation score during the post-test compared to the pre-test. This study shows that it is possible to promote joint attention with a low-intensity treatment programme. The results concerning imitation are more modest. Future replications should involve measures of stability and generalization.
C1 [Warreyn, Petra; Roeyers, Herbert] Univ Ghent, B-9000 Ghent, Belgium.
RP Warreyn, P (reprint author), Univ Ghent, Dept Expt Clin & Hlth Psychol, Res Grp Dev Disorders, Henri Dunantlaan 2, B-9000 Ghent, Belgium.
EM petra.warreyn@ugent.be
CR Anisfeld M, 1996, DEV REV, V16, P149, DOI 10.1006/drev.1996.0006
   (APA) APA, 2000, DIAGN STAT MAN MENT
   BAKEMAN R, 1984, CHILD DEV, V55, P1278, DOI 10.2307/1129997
   BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
   Bono MA, 2004, J AUTISM DEV DISORD, V34, P495, DOI 10.1007/s10803-004-2545-x
   Bos A, 1997, WPPSI R WECHSLER PRE
   Brown J. D., 1998, INTERSUBJECTIVE COMM, P260
   Bruinsma Y, 2004, MENT RETARD DEV D R, V10, P169, DOI 10.1002/mrdd.20036
   Butterworth G., 1995, JOINT ATTENTION ITS, P29
   Charman T, 2000, COGNITIVE DEV, V15, P481, DOI 10.1016/S0885-2014(01)00037-5
   Charman T, 1998, AUTISM INT J RES PRA, V2, P61, DOI 10.1177/1362361398021006
   Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
   CHARMAN T, 1994, DEV PSYCHOPATHOL, V6, P403, DOI 10.1017/S0954579400006015
   Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830
   COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
   Corkum V, 1998, DEV PSYCHOL, V34, P28, DOI 10.1037/0012-1649.34.1.28
   Corsello CM, 2005, INFANT YOUNG CHILD, V18, P74
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   De Schuymer L, 2011, EARLY HUM DEV, V87, P265, DOI 10.1016/j.earlhumdev.2011.01.029
   Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
   TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
   Farroni T, 2000, VIS COGN, V7, P705
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Heimann M, 2002, IMITATIVE MIND DEV E, P74, DOI DOI 10.1017/CB09780511489969.005
   Hoehl S, 2009, CHILD DEV, V80, P968, DOI 10.1111/j.1467-8624.2009.01311.x
   Hood BM, 1998, PSYCHOL SCI, V9, P131, DOI 10.1111/1467-9280.00024
   Hwang B, 2000, J ASSOC PERS SEVERE, V25, P18, DOI 10.2511/rpsd.25.1.18
   Ingersoll B, 2007, J AUTISM DEV DISORD, V37, P1446, DOI 10.1007/s10803-006-0221-z
   Ingersoll B, 2006, J AUTISM DEV DISORD, V36, P487, DOI 10.1007/s10803-006-0089-y
   Ingersoll B, 2008, INFANT YOUNG CHILD, V21, P107
   Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P1078, DOI 10.1016/j.rasd.2010.12.001
   Jones EA, 2006, BEHAV MODIF, V30, P782, DOI 10.1177/0145445506289392
   Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
   Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Koegel R. L., 2006, PIVOTAL RESPONSE TRE
   Kugiumutzakis G., 1999, IMITATION INFANCY, P36
   Ledford JR, 2011, TOP EARLY CHILD SPEC, V30, P245, DOI 10.1177/0271121410363831
   Libby S, 1997, J AUTISM DEV DISORD, V27, P365, DOI 10.1023/A:1025801304279
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Mahoney G, 2003, TOP EARLY CHILD SPEC, V23, P77
   Markus J, 2000, SOC DEV, V9, P302, DOI 10.1111/1467-9507.00127
   McGee GG, 2000, PRESCHOOL ED PROGRAM, P157
   McGee GG, 1999, J ASSOC PERS SEVERE, V24, P133, DOI 10.2511/rpsd.24.3.133
   Meek SE, 2012, RES AUTISM SPECT DIS, V6, P815, DOI 10.1016/j.rasd.2011.11.001
   Meindl JN, 2011, RES DEV DISABIL, V32, P1441, DOI 10.1016/j.ridd.2011.02.013
   Meltzoff AN, 1999, J PIAGET SY, P53
   Meltzoff AN, 2002, INFANT BEHAV DEV, V25, P39, DOI 10.1016/S0163-6383(02)00090-5
   MELTZOFF AN, 1988, CHILD DEV, V59, P217, DOI 10.2307/1130404
   MELTZOFF AN, 1985, CHILD DEV, V56, P62, DOI 10.1111/j.1467-8624.1985.tb00086.x
   MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
   Morales M, 1998, INFANT BEHAV DEV, V21, P373, DOI 10.1016/S0163-6383(98)90014-5
   MORGAN SB, 1989, J CHILD PSYCHOL PSYC, V30, P857, DOI 10.1111/j.1469-7610.1989.tb00287.x
   MUNDY P, 1994, DEV PSYCHOPATHOL, V6, P389, DOI 10.1017/S0954579400006003
   Mundy P, 1997, J AUTISM DEV DISORD, V27, P653, DOI 10.1023/A:1025802832021
   Mundy P, 1993, MANUAL ABRIDGED EARL
   MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
   MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
   Nadel J., 2002, IMITATIVE MIND DEV E, P42, DOI 10.1017/CBO9780511489969.003
   NADELBRULFERT J, 1982, INT J BEHAV DEV, V5, P95
   Nakagawa S, 2004, BEHAV ECOL, V15, P1044, DOI 10.1093/beheco/arh107
   OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
   Perneger TV, 1998, BRIT MED J, V316, P1236
   PHILLIPS W, 1992, DEV PSYCHOPATHOL, V4, P375, DOI 10.1017/S0954579400000845
   Poon KK, 2012, J AUTISM DEV DISORD, V42, P1064, DOI 10.1007/s10803-011-1349-z
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Roeyers H, 1998, DEV PSYCHOPATHOL, V10, P441, DOI 10.1017/S0954579498001680
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Rogers SJ, 2009, PLAY ENGAGEMENT EARL, VI
   Rogers SJ, 1999, INFANT YOUNG CHILD, V12, P1
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Schaerlaekens A, 1993, REYNELL TAALONTWIKKE
   Schopler E, 1984, HDB SCH PSYCHOL, P629
   Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
   Spelberg HC, 1998, SCHLICHTING TEST TAA
   Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091
   Stone WL, 2001, AUTISM, V5, P341, DOI 10.1177/1362361301005004002
   Tomasello M, 2001, J CROSS CULT PSYCHOL, V32, P135, DOI 10.1177/0022022101032002002
   Tomasello M., 1995, JOINT ATTENTION ITS, P103
   Uzgiris I., 1975, ASSESSMENT INFANCY O
   Warreyn P, 2007, J AUTISM DEV DISORD, V37, P501, DOI 10.1007/s10803-006-0184-0
   Warreyn P, 2012, INTERVENTIE BI UNPUB
   Wechsler D., 1989, WECHSLER PRESCHOOL P
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Whalen C, 2006, J AUTISM DEV DISORD, V36, P655, DOI 10.1007/s10803-006-0108-z
   Whalen C, 2003, J CHILD PSYCHOL PSYC, V44, P456, DOI 10.1111/1469-7610.00135
   White PJ, 2011, RES AUTISM SPECT DIS, V5, P1283, DOI 10.1016/j.rasd.2011.02.003
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Young GS, 2011, DEV PSYCHOL, V47, P1565, DOI 10.1037/a0025418
NR 90
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 658
EP 671
DI 10.1177/1362361313493834
PG 14
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900005
PM 24104513
ER

PT J
AU Hesselmark, E
   Plenty, S
   Bejerot, S
AF Hesselmark, Eva
   Plenty, Stephanie
   Bejerot, Susanne
TI Group cognitive behavioural therapy and group recreational activity for
   adults with autism spectrum disorders: A preliminary randomized
   controlled trial
SO AUTISM
LA English
DT Article
DE adult; Asperger disorder; autism; cognitive behaviour therapy; group;
   randomized controlled trial
ID QUALITY-OF-LIFE; FUNCTIONING AUTISM; ASPERGER-SYNDROME; YOUNG-ADULTS;
   DROP-OUT; CHILDREN; ANXIETY; ADOLESCENTS; POPULATION; VALIDATION
AB Although adults with autism spectrum disorder are an increasingly identified patient population, few treatment options are available. This preliminary randomized controlled open trial with a parallel design developed two group interventions for adults with autism spectrum disorders and intelligence within the normal range: cognitive behavioural therapy and recreational activity. Both interventions comprised 36 weekly 3-h sessions led by two therapists in groups of 6-8 patients. A total of 68 psychiatric patients with autism spectrum disorders participated in the study. Outcome measures were Quality of Life Inventory, Sense of Coherence Scale, Rosenberg Self-Esteem Scale and an exploratory analysis on measures of psychiatric health. Participants in both treatment conditions reported an increased quality of life at post-treatment (d = 0.39, p < 0.001), with no difference between interventions. No amelioration of psychiatric symptoms was observed. The dropout rate was lower with cognitive behavioural therapy than with recreational activity, and participants in cognitive behavioural therapy rated themselves as more generally improved, as well as more improved regarding expression of needs and understanding of difficulties. Both interventions appear to be promising treatment options for adults with autism spectrum disorder. The interventions' similar efficacy may be due to the common elements, structure and group setting. Cognitive behavioural therapy may be additionally beneficial in terms of increasing specific skills and minimizing dropout.
C1 [Hesselmark, Eva; Plenty, Stephanie; Bejerot, Susanne] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
   [Bejerot, Susanne] St Goran Hosp, VUB KOGNUS, Northern Stockholm Psychiat, SE-11281 Stockholm, Sweden.
RP Hesselmark, E (reprint author), St Goran Hosp, VUB KOGNUS, Northern Stockholm Psychiat, SE-11281 Stockholm, Sweden.
EM ehesselmark@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Andersen S, 2001, ADDICT RES THEORY, V9, P239, DOI 10.3109/16066350109141752
   ANTONOVSKY A, 1993, SOC SCI MED, V36, P725, DOI 10.1016/0277-9536(93)90033-Z
   Attwood T., 2007, COMPLETE GUIDE ASPER
   Axen M, 2010, REGIONALT VARDPROGRA
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   Bejerot S, 2011, PSYKOPEDAGOGIS UNPUB
   Bejerot S, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-68
   Billstedt E, 2011, AUTISM, V15, P7, DOI 10.1177/1362361309346066
   Cappadocia MC, 2012, J AUTISM DEV DISORD, V42, P266, DOI 10.1007/s10803-011-1241-x
   DEROGATIS LR, 1977, J CLIN PSYCHOL, V33, P981, DOI 10.1002/1097-4679(197710)33:4<981::AID-JCLP2270330412>3.0.CO;2-0
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Frisch M. B., 1992, PSYCHOL ASSESSMENT, V4, P92, DOI DOI 10.1037/1040-3590.4.1.92
   Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x
   Gantman A, 2012, J AUTISM DEV DISORD, V42, P1094, DOI 10.1007/s10803-011-1350-6
   Garety PA, 2008, BRIT J PSYCHIAT, V192, P412, DOI 10.1192/bjp.bp.107.043570
   Gaus VL, 2007, COGNITIVE BEHAV THER
   Gaus VL, 2011, J CONTEMP PSYCHOTHER, V41, P47, DOI DOI 10.1007/S10879-010-9159-8
   Gerhardt PF, 2010, J CONTEMP PSYCHOTHER, V41, P37
   Guy W, 1976, DHEW PUBL, P218
   Hillier AJ, 2011, J DEV PHYS DISABIL, V23, P267, DOI 10.1007/s10882-011-9226-4
   Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
   Kessler RC, 2005, PSYCHOL MED, V35, P245, DOI 10.1017/S0033291704002892
   Kopp S, 2010, RES DEV DISABIL, V31, P350, DOI 10.1016/j.ridd.2009.09.017
   Lang R, 2010, DEV NEUROREHABIL, V13, P53, DOI 10.3109/17518420903236288
   Linehan M, 1984, DIALECTICAL BEHAV TH
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   Minshew NJ, 2008, J AUTISM DEV DISORD, V38, P1485, DOI 10.1007/s10803-007-0528-4
   Munro JD, 2010, J SYSTEMIC THERAPIES, V29, P82, DOI 10.1521/jsyt.2010.29.3.82
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Nylander L, 2001, ACTA PSYCHIAT SCAND, V103, P428, DOI 10.1034/j.1600-0447.2001.00175.x
   Palmen A, 2011, DEV NEUROREHABIL, V14, P297, DOI 10.3109/17518423.2011.595433
   Paunovic N, 2004, J PSYCHOPATHOL BEHAV, V26, P15, DOI 10.1023/B:JOBA.0000007452.65270.13
   ROSENBERG M, 1962, J PSYCHIAT RES, V1, P135, DOI 10.1016/0022-3956(62)90004-3
   Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
   Shattuck PT, 2007, J AUTISM DEV DISORD, V37, P1735, DOI 10.1007/s10803-006-0307-7
   Sung M, 2011, CHILD PSYCHIAT HUM D, V42, P634, DOI 10.1007/s10578-011-0238-1
   Tantam D., 2000, AUTISM INT J RES PRA, V4, P47, DOI DOI 10.1177/1362361300004001004
   Villeneuve K, 2010, SCHIZOPHR RES, V121, P266, DOI 10.1016/j.schres.2010.04.003
   Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
   Vlachou M, 2011, EDUC PSYCHOL REV, V23, P329, DOI 10.1007/s10648-011-9153-z
   Weiss JA, 2010, CLIN PSYCHOL, V446, P438
   White SW, 2010, FOCUS AUTISM DEV DIS, V25, P209, DOI 10.1177/1088357610380595
   WING L, 1981, PSYCHOL MED, V11, P115
   Wink LK, 2010, CURR TREAT OPTION NE, V12, P529, DOI 10.1007/s11940-010-0091-8
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
NR 48
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 672
EP 683
DI 10.1177/1362361313493681
PG 12
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900006
PM 24089423
ER

PT J
AU Callenmark, B
   Kjellin, L
   Ronnqvist, L
   Bolte, S
AF Callenmark, Bjorn
   Kjellin, Lars
   Ronnqvist, Louise
   Bolte, Sven
TI Explicit versus implicit social cognition testing in autism spectrum
   disorder
SO AUTISM
LA English
DT Article
DE Asperger's syndrome; assessment; mentalizing; neurodevelopmental
   disorders; psychometrics; theory of mind
ID ASPERGER-SYNDROME; EYES TEST; MIND; ADULTS; DEFICITS; CHILDREN; SYSTEMS
AB Although autism spectrum disorder is defined by reciprocal social-communication impairments, several studies have found no evidence for altered social cognition test performance. This study examined explicit (i.e. prompted) and implicit (i.e. spontaneous) variants of social cognition testing in autism spectrum disorder. A sample of 19 adolescents with autism spectrum disorder and 19 carefully matched typically developing controls completed the Dewey Story Test. 'Explicit' (multiple-choice answering format) and 'implicit' (free interview) measures of social cognition were obtained. Autism spectrum disorder participants did not differ from controls regarding explicit social cognition performance. However, the autism spectrum disorder group performed more poorly than controls on implicit social cognition performance in terms of spontaneous perspective taking and social awareness. Findings suggest that social cognition alterations in autism spectrum disorder are primarily implicit in nature and that an apparent absence of social cognition difficulties on certain tests using rather explicit testing formats does not necessarily mean social cognition typicality in autism spectrum disorder.
C1 [Callenmark, Bjorn] Stockholm Cty Council, Stockholm, Sweden.
   [Callenmark, Bjorn; Kjellin, Lars] Orebro Cty Council, Orebro, Sweden.
   [Kjellin, Lars] Univ Orebro, Orebro, Sweden.
   [Ronnqvist, Louise] Umea Univ, S-90187 Umea, Sweden.
   [Bolte, Sven] Karolinska Inst, S-10401 Stockholm, Sweden.
RP Bolte, S (reprint author), Karolinska Inst KIND, CAP Res Ctr, Ctr Neurodev Disorders, Dept Womens & Childrens Hlth, Gavlegatan 22 B, S-11330 Stockholm, Sweden.
EM sven.bolte@ki.se
CR Baird J. A., 2001, INTENTIONS INTENTION, P193
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Blair RJR, 2000, BRAIN, V123, P1122, DOI 10.1093/brain/123.6.1122
   BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
   Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
   Buitelaar JK, 1999, J AUTISM DEV DISORD, V29, P33, DOI 10.1023/A:1025966532041
   Apperly IA, 2009, PSYCHOL REV, V116, P953, DOI 10.1037/a0016923
   Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
   Dewey M, 1991, AUTISM ASPERGER SYND, P184, DOI 10.1017/CBO9780511526770.006
   Dewey M, 1998, AUTISM ASPERGERS SYN, P234
   Dewrang P, 2011, ASPERGER SYNDROME SO
   ELLIS HD, 1994, EUR CHILD ADOLES PSY, V3, P255
   Frith CD, 2008, NEURON, V60, P503, DOI 10.1016/j.neuron.2008.10.032
   Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x
   Frith U, 1999, MIND LANG, V14, P1
   Frith U, 2005, CURR BIOL, V11, P786
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Klin A, 2004, AUTISM MIND BRAIN, P127
   Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Low J, 2012, BRIT J DEV PSYCHOL, V30, P1, DOI 10.1111/j.2044-835X.2011.02074.x
   Nah Y, 2010, AUTISM, V14, P1
   OZONOFF S, 1990, J CHILD PSYCHOL PSYC, V31, P343, DOI 10.1111/j.1469-7610.1990.tb01574.x
   PAUL R, 1985, J SPEECH HEAR RES, V28, P475
   Ponnet KS, 2004, AUTISM, V8, P249, DOI 10.1177/1362361304045214
   Povinelli DJ, 2004, MIND LANG, V19, P1, DOI 10.1111/j.1468-0017.2004.00244.x
   Satpute AB, 2006, BRAIN RES, V1079, P86, DOI 10.1016/j.brainres.2006.01.005
   Senju A, 2012, NEUROSCIENTIST, V18, P108, DOI 10.1177/1073858410397208
   Senju A, 2012, BRAIN DEV, V35, P96
   Soderstrand P, 2012, NORD PSYCHOL, V64, P30, DOI 10.1080/19012276.2012.693729
   Soderstrand P, 2004, INTUITIONENS NEUROPS
   Spunt RP, 2013, PSYCHOL SCI, V24, P80, DOI 10.1177/0956797612450884
   Vermeulen P, 2002, BETER VROEG DAN LAAT
   Wechsler D., 2003, WECHSLER ADULT INTEL
   Wechsler D., 2007, WECHSLER INTELLIGENC
   Wechsler D., 1999, WECHSLER INTELLIGENC
NR 37
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 684
EP 693
DI 10.1177/1362361313492393
PG 10
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900007
PM 24104519
ER

PT J
AU Leezenbaum, NB
   Campbell, SB
   Butler, D
   Iverson, JM
AF Leezenbaum, Nina B.
   Campbell, Susan B.
   Butler, Derrecka
   Iverson, Jana M.
TI Maternal verbal responses to communication of infants at low and
   heightened risk of autism
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; communication development; gesture; parent
   verbal responsiveness
ID YOUNG-CHILDREN; SIBLINGS; LANGUAGE; MOTHERS; SPECTRUM; GESTURES
AB This study investigates mothers' responses to infant communication among infants at heightened genetic risk (high risk) of autism spectrum disorder compared to infants with no such risk (low risk). A total of 26 infants, 12 of whom had an older sibling with autism spectrum disorder, were observed during naturalistic in-home interaction and semistructured play with their mothers at 13 and 18 months of age. Results indicate that overall, mothers of low-risk and high-risk infants were highly and similarly responsive to their infants' communicative behaviors. However, examination of infant vocal and gestural communication development together with maternal verbal responses and translations (i.e. verbally labeling a gesture referent) suggests that delays in early communication development observed among high-risk infants may alter the input that these infants receive; this in turn may have cascading effects on the subsequent development of communication and language.
C1 [Leezenbaum, Nina B.; Campbell, Susan B.; Iverson, Jana M.] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Butler, Derrecka] No Illinois Univ, De Kalb, IL 60115 USA.
RP Leezenbaum, NB (reprint author), Univ Pittsburgh, Dept Psychol, 3309 Sennott Sq,210 S Bouquet St, Pittsburgh, PA 15260 USA.
EM nbl3@pitt.edu
CR (APA) APA, 2000, DIAGN STAT MAN MENT
   BATES E., 1976, LANGUAGE CONTEXT
   Bates E., 1979, EMERGENCE SYMBOLS CO
   Bloom L., 1993, TRANSITION INFANCY L
   Cassel TD, 2007, J AUTISM DEV DISORD, V37, P122, DOI 10.1007/s10803-006-0337-1
   TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
   Goldin-Meadow S, 2007, DEVELOPMENTAL SCI, V10, P778, DOI 10.1111/j.1467-7687.2007.00636.x
   GOLINKOFF RM, 1986, J CHILD LANG, V13, P455
   Gros-Louis J, 2006, INT J BEHAV DEV, V30, P509, DOI 10.1177/0165025406071914
   HARDING CG, 1979, CHILD DEV, V50, P33, DOI 10.1111/j.1467-8624.1979.tb02976.x
   Hess CR, 2012, J AUTISM DEV DISORD, V42, P575, DOI 10.1007/s10803-011-1282-1
   Iverson J. M., 1998, TRANSITIONS PRELINGU, P59
   IVERSON JM, 1994, COGNITIVE DEV, V9, P23, DOI 10.1016/0885-2014(94)90018-3
   Iverson JM, 2005, PSYCHOL SCI, V16, P367, DOI 10.1111/j.0956-7976.2005.01542.x
   Iverson JM, 2007, J AUTISM DEV DISORD, V37, P158, DOI 10.1007/s10803-006-0339-z
   Kishimoto T, 2007, INFANT BEHAV DEV, V30, P562, DOI 10.1016/j.infbeh.2007.04.001
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Marschik PB, 2012, DEV MED CHILD NEUROL, V54, P451, DOI 10.1111/j.1469-8749.2012.04123.x
   MASUR EF, 1982, J CHILD LANG, V9, P23
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Paul R, 2011, J CHILD PSYCHOL PSYC, V52, P588, DOI 10.1111/j.1469-7610.2010.02332.x
   Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
   Sameroff A. J., 1983, HDB CHILD PSYCHOL, V1, P237
   Siegel S., 1988, NONPARAMETRIC STAT B
   Snow Catherine, 1986, LANG ACQUIS, P69
   Tamis-LeMonda CS, 2001, CHILD DEV, V72, P748, DOI 10.1111/1467-8624.00313
   WETHERBY AM, 1988, J SPEECH HEAR RES, V31, P240
   Winder B, 2012, DEV PSYCHOL, P48
   Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x
NR 29
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 694
EP 703
DI 10.1177/1362361313491327
PG 10
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900008
PM 24113343
ER

PT J
AU Stagg, SD
   Slavny, R
   Hand, C
   Cardoso, A
   Smith, P
AF Stagg, Steven D.
   Slavny, Rachel
   Hand, Charlotte
   Cardoso, Alice
   Smith, Pamela
TI Does facial expressivity count? How typically developing children
   respond initially to children with autism
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; facial expressivity; first impressions;
   friendship formation
ID PHYSICAL ATTRACTIVENESS; IMPRESSION-FORMATION; ASPERGERS-SYNDROME; 1ST
   IMPRESSIONS; EMOTION; INTERVENTION; CONSEQUENCES; PERCEPTIONS;
   ADOLESCENTS; LONELINESS
AB Research investigating expressivity in children with autism spectrum disorder has reported flat affect or bizarre facial expressivity within this population; however, the impact expressivity may have on first impression formation has received little research input. We examined how videos of children with autism spectrum disorder were rated for expressivity by adults blind to the condition. We further investigated the friendship ratings given by 44 typically developing children to the same videos. These ratings were compared to friendship ratings given to video clips of typically developing children. Results demonstrated that adult raters, blind to the diagnosis of the children in the videos, rated children with autism spectrum disorder as being less expressive than typically developing children. These autism spectrum disorder children were also rated lower than typically developing children on all aspects of our friendship measures by the 44 child raters. Results suggest that impression formation is less positive towards children with autism spectrum disorder than towards typically developing children even when exposure time is brief.
C1 [Stagg, Steven D.] Anglia Ruskin Univ, Cambridge CB1 1PT, England.
   [Slavny, Rachel; Hand, Charlotte; Cardoso, Alice; Smith, Pamela] Univ London, London WC1E 7HU, England.
RP Stagg, SD (reprint author), Anglia Ruskin Univ, East Rd, Cambridge CB1 1PT, England.
EM steven.stagg@anglia.ac.uk
CR AMBADY N, 1992, PSYCHOL BULL, V111, P256, DOI 10.1037/0033-2909.111.2.256
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Apperly IA, 2009, DEV PSYCHOL, V45, P190, DOI 10.1037/a0014098
   Argyle M, 1994, PSYCHOL INTERPERSONA
   Bar M, 2006, EMOTION, V6, P269, DOI 10.1037/1528-3542.6.2.269
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bieberich AA, 1998, J AUTISM DEV DISORD, V28, P333, DOI 10.1023/A:1026016804357
   Boutot F, 2007, INTERV SCH CLIN, V42, P156
   Butler EA, 2003, EMOTION, V3, P48, DOI 10.1037/1528-3542.3.1.48
   CAPPS L, 1993, J CONSULT CLIN PSYCH, V61, P475, DOI 10.1037/0022-006X.61.3.475
   Chamberlain B, 2007, J AUTISM DEV DISORD, V37, P230, DOI 10.1007/s10803-006-0164-4
   Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
   DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   EKMAN P, 1987, J PERS SOC PSYCHOL, V53, P712, DOI 10.1037/0022-3514.53.4.712
   Ellis S, 2008, RES REPORT SPECIAL E
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Frankel F, 2011, BRAIN RES, V1380, P240, DOI 10.1016/j.brainres.2010.09.047
   Gena A, 1996, J APPL BEHAV ANAL, V29, P291, DOI 10.1901/jaba.1996.29-291
   Harrigan J. A., 2005, NEW HDB METHODS NONV
   HENDRICK C, 1970, J PERS SOC PSYCHOL, V15, P158, DOI 10.1037/h0029203
   Hobson P, 1993, UNDERSTANDING OTHER, P204
   Iobst E, 2009, RES AUTISM SPECT DIS, V3, P401, DOI 10.1016/j.rasd.2008.08.006
   Kanner L, 1943, NERV CHILD, V2, P217
   KARRAKER KH, 1990, BASIC APPL SOC PSYCH, V11, P371, DOI 10.1207/s15324834basp1104_2
   Kasari C., 2007, CLIN MANUAL TREATMEN, P235
   Klin A, 2005, HDB AUTISM PERVASIVE, P682
   Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
   LOVELAND KA, 1994, DEV PSYCHOPATHOL, V6, P433, DOI 10.1017/S0954579400006039
   MUESER KT, 1984, J PERS SOC PSYCHOL, V46, P469
   Nowicki S., 1992, HELPING CHILD WHO DO
   PALMER MT, 1995, HUM COMMUN RES, V22, P128, DOI 10.1111/j.1468-2958.1995.tb00364.x
   Reddy V, 2002, BRIT J PSYCHOL, V93, P219, DOI 10.1348/000712602162553
   Samson D, 2010, J EXP PSYCHOL HUMAN, V36, P1255, DOI 10.1037/a0018729
   SNOW ME, 1987, J AM ACAD CHILD PSY, V26, P836, DOI 10.1097/00004583-198726060-00006
   Spek AA, 2010, J AUTISM DEV DISORD, V40, P280, DOI 10.1007/s10803-009-0860-y
   STEWART RH, 1965, J PERS SOC PSYCHOL, V1, P161, DOI 10.1037/h0021641
   Swaim KF, 2001, J AUTISM DEV DISORD, V31, P195, DOI 10.1023/A:1010703316365
   Tardif C, 2007, J AUTISM DEV DISORD, V37, P1469, DOI 10.1007/s10803-006-0223-x
   Thompson JJ, 1973, WORDS NONVERBAL COMM
   Todorov A, 2003, J EXP SOC PSYCHOL, V39, P549, DOI 10.1016/S0022-1031(03)00059-3
   Volker MA, 2009, FOCUS AUTISM DEV DIS, V24, P195, DOI 10.1177/1088357609347325
   WEEKS SJ, 1987, J CHILD PSYCHOL PSYC, V28, P137, DOI 10.1111/j.1469-7610.1987.tb00658.x
   Wentzel KR, 2004, J EDUC PSYCHOL, V96, P195, DOI 10.1037/0022-0663.96.2.195
   White SW, 2009, J AUTISM DEV DISORD, V39, P1006, DOI 10.1007/s10803-009-0713-8
   Whitehouse AJO, 2009, J ADOLESCENCE, V32, P309, DOI 10.1016/j.adolescence.2008.03.004
   Willis J, 2006, PSYCHOL SCI, V17, P592, DOI 10.1111/j.1467-9280.2006.01750.x
   YIRMIYA N, 1989, J CHILD PSYCHOL PSYC, V30, P725, DOI 10.1111/j.1469-7610.1989.tb00785.x
NR 48
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 704
EP 711
DI 10.1177/1362361313492392
PG 8
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900009
PM 24121180
ER

PT J
AU Sharp, WG
   Burrell, TL
   Jaquess, DL
AF Sharp, William G.
   Burrell, T. Lindsey
   Jaquess, David L.
TI The Autism MEAL Plan: A parent-training curriculum to manage eating
   aversions and low intake among children with autism
SO AUTISM
LA English
DT Article
DE autism; food selectivity; intervention; mealtime problems; parent
   training; pediatric feeding disorders
ID SPECTRUM DISORDERS; FEEDING PROBLEMS; FOOD SELECTIVITY; DISRUPTIVE
   BEHAVIOR; TREATMENT PROGRAM; YOUNG-CHILDREN; OUTCOMES; INTERVENTION;
   FAMILIES; STRESS
AB Feeding problems represent a frequent concern reported by caregivers of children with autism spectrum disorders, and growing evidence suggests atypical patterns of intake may place this population at risk of nutritional and/or related medical issues, including chronic vitamin and mineral deficiencies, poor bone growth, and obesity. This combination of factors emphasizes a clear need to identify and disseminate evidence-based treatment of feeding problems associated with autism spectrum disorders. Behavioral intervention represents an effective treatment for chronic feeding concerns in this population; however, evidence has largely been established with trained therapists working in highly structured settings. This pilot study seeks to fill this gap in the literature by describing and evaluating the Autism MEAL Plan, a behaviorally based parent-training curriculum to address feeding problems associated with autism spectrum disorders. We assessed the feasibility of the intervention in terms of program content and study protocol (e. g. recruitment and retention of participants, assessment procedures), as well as efficacy in terms of changes in feeding behaviors. A total of 10 families participated in the treatment condition, and the program was evaluated using a waitlist control design (n = 9), representing the first randomized-control study of a feeding intervention in autism spectrum disorders. Results provide provisional support regarding the utility of the program, including high social validity, parent perception of effectiveness, and reduced levels of caregiver stress following intervention. Implications, limitations, and future directions for this line of research are discussed.
C1 [Sharp, William G.; Burrell, T. Lindsey; Jaquess, David L.] Marcus Autism Ctr, Atlanta, GA 30329 USA.
   [Sharp, William G.; Jaquess, David L.] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
   [Burrell, T. Lindsey] Texas Tech Univ, Lubbock, TX 79409 USA.
RP Sharp, WG (reprint author), Marcus Autism Ctr, Pediat Psychol & Feeding Disorders Program, 1920 Briarcliff Rd, Atlanta, GA 30329 USA.
EM william.sharp@choa.org
CR Abidin RR, 1995, PARENTING STRESS IND
   Ahearn WH, 2001, J AUTISM DEV DISORD, V31, P505, DOI 10.1023/A:1012221026124
   Bandini LG, 2010, J PEDIATR-US, V157, P259, DOI 10.1016/j.jpeds.2010.02.013
   BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6
   Brookman-Frazee L, 2004, J POSIT BEHAV INTERV, V6, P195, DOI 10.1177/10983007040060040201
   Buschbacher P, 2004, RES PRACT PERS SEV D, V29, P25, DOI 10.2511/rpsd.29.1.25
   Campbell M, 2007, HELPING PARENTS PREV, P67
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Cornish E, 2002, J HUM NUTR DIET, V15, P261, DOI 10.1046/j.1365-277X.2002.00372.x
   Creswell C, 2007, CLIN CHILD FAM PSYCH, V10, P232, DOI 10.1007/s10567-007-0019-3
   Feldman MA, 2002, BEHAV INTERVENT, V17, P75, DOI 10.1002/bin.111
   Field D, 2003, J PAEDIATR CHILD H, V39, P299, DOI 10.1046/j.1440-1754.2003.00151.x
   GIROLAMETTO L, 1994, J SPEECH HEAR RES, V37, P1178
   Greer AJ, 2008, J PEDIATR PSYCHOL, V33, P612, DOI 10.1093/jpepsy/jsm116
   Hediger ML, 2008, J AUTISM DEV DISORD, V38, P848, DOI 10.1007/s10803-007-0453-6
   Ho H. H., 1997, FOCUS AUTISM OTHER D, V12, P187
   Horner RH, 2002, J AUTISM DEV DISORD, V32, P423, DOI 10.1023/A:1020593922901
   Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
   Ingersoll B, 2006, J POSIT BEHAV INTERV, V8, P79, DOI 10.1177/10983007060080020601
   KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P141, DOI 10.1007/BF01058147
   Koegel RL, 1996, J AUTISM DEV DISORD, V33, P3
   Kuczmarski RJ, 2000, ADV DATA, V314, P1
   Laud RB, 2009, BEHAV MODIF, V33, P520, DOI 10.1177/0145445509346729
   Ledford J. R., 2006, FOCUS AUTISM OTHER D, V21, P153, DOI DOI 10.1177/10883576060210030401
   Leon AC, 2011, J PSYCHIATR RES, V45, P626, DOI 10.1016/j.jpsychires.2010.10.008
   Lukens CT, 2008, J AUTISM DEV DISORD, V38, P342, DOI 10.1007/s10803-007-0401-5
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P455, DOI 10.1016/j.rasd.2008.09.005
   McNeil CB, 2005, ED TREATMENT CHILDRE, V28, P182
   Minjarez MB, 2011, J AUTISM DEV DISORD, V41, P92, DOI 10.1007/s10803-010-1027-6
   Najdowski AC, 2003, J APPL BEHAV ANAL, V36, P383, DOI 10.1901/jaba.2003.36-383
   Najdowski AC, 2010, BEHAV INTERVENT, V25, P89, DOI 10.1002/bin.298
   Neary EM, 2002, INFANT YOUNG CHILD, V14, P53
   Sanders MR, 2000, J CONSULT CLIN PSYCH, V68, P624, DOI 10.1037//002-006X.68.4.624
   Sharp WG, 2011, FOCUS AUTISM DEV DIS, V26, P37, DOI 10.1177/1088357609349245
   Sharp WG, 2013, J AUTISM DEV DISORD, V43, P2159, DOI 10.1007/s10803-013-1771-5
   Sharp WG, 2013, RES AUTISM SPECT DIS, V7, P56, DOI 10.1016/j.rasd.2012.07.001
   Sharp WG, 2011, CLIN CHILD FAM PSYCH, V13, P348
   Solomon M, 2008, J AUTISM DEV DISORD, V38, P1767, DOI 10.1007/s10803-008-0567-5
   STARK LJ, 1990, J PEDIATR PSYCHOL, V15, P659, DOI 10.1093/jpepsy/15.5.659
   Symon JB, 2001, J POSIT BEHAV INTERV, V3, P160, DOI 10.1177/109830070100300304
   Williams KE, 2007, TREATING EATING PROB
   Zimmer MH, 2012, J AUTISM DEV DISORD, V42, P549, DOI 10.1007/s10803-011-1268-z
NR 43
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 712
EP 722
DI 10.1177/1362361313489190
PG 11
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900010
PM 24101716
ER

PT J
AU McConachie, H
   McLaughlin, E
   Grahame, V
   Taylor, H
   Honey, E
   Tavernor, L
   Rodgers, J
   Freeston, M
   Hemm, C
   Steen, N
   Le Couteur, A
AF McConachie, Helen
   McLaughlin, Eleanor
   Grahame, Victoria
   Taylor, Helen
   Honey, Emma
   Tavernor, Laura
   Rodgers, Jacqui
   Freeston, Mark
   Hemm, Cahley
   Steen, Nick
   Le Couteur, Ann
TI Group therapy for anxiety in children with autism spectrum disorder
SO AUTISM
LA English
DT Article
DE anxiety; autism spectrum disorder; cognitive behaviour therapy; pilot
   randomised trial
ID HIGH-FUNCTIONING AUTISM; COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; PSYCHOMETRIC PROPERTIES; ASPERGER-SYNDROME; DSM-IV;
   ADOLESCENTS; PREVALENCE; SAMPLE; SCALE
AB Aim: To investigate the acceptability and feasibility of adapted group therapy for anxiety in children with autism spectrum disorder in a pilot randomised controlled trial.
   Method: A total of 32 children aged 9-13 years were randomised to immediate or delayed therapy using the 'Exploring Feelings' manual (Attwood, 2004). Child and parent groups were run in parallel, for seven weekly sessions, under the supervision of experienced psychologists. The primary blinded outcome measures addressed change in overall functioning and in severity of the primary anxiety diagnosis after 3 months.
   Results: Children met diagnostic criteria for 1-6 anxiety disorders (median 3). At end point, both parents and children in the immediate therapy group were more likely to report a reduction in anxiety symptoms. Fidelity of delivery of the group therapy was high, and attendance was 91%.
   Conclusions: This pilot trial established that children and families were willing to be recruited and randomised, the outcome measures were acceptable, the format and content of the groups were feasible within UK child and adolescent mental health services, the intervention was appreciated by families and attrition was very small.
C1 [McConachie, Helen; Rodgers, Jacqui; Freeston, Mark; Hemm, Cahley; Steen, Nick; Le Couteur, Ann] Newcastle Univ, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
   [McLaughlin, Eleanor; Grahame, Victoria; Taylor, Helen; Honey, Emma; Tavernor, Laura] Northumberland Tyne & Wear NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England.
RP McConachie, H (reprint author), Newcastle Univ, Royal Victoria Infirm, Inst Hlth & Soc, Sir James Spence Inst, 3rd Floor, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
EM helen.mcconachie@ncl.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Anderson S, 2006, BEHAV COGN PSYCHOTH, V34, P293, DOI 10.1017/S1352465805002651
   Arain M, 2010, BMC MED RES METHODOL, V10, P1
   Attwood T, 2004, EXPLORING FEELINGS C
   Blackburn IM, 2001, BEHAV COGN PSYCHOTH, V29, P431, DOI 10.1017/S1352465801004040
   Bogels SM, 2006, CLIN PSYCHOL REV, V26, P834, DOI 10.1016/j.cpr.2005.08.001
   Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
   Brookman-Frazee LI, 2012, J AUTISM DEV DISORD, V42, P1651, DOI 10.1007/s10803-011-1406-7
   Cappadocia MC, 2011, RES AUTISM SPECT DIS, V5, P70, DOI 10.1016/j.rasd.2010.04.001
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Chorpita BF, 2011, CLIN PSYCHOL-SCI PR, V18, P154
   Creswell C, 2007, CLIN CHILD FAM PSYCH, V10, P232, DOI 10.1007/s10567-007-0019-3
   DONABEDIAN A, 1966, MILBANK FUND Q, V44, P166, DOI 10.2307/3348969
   Donoghue Kate, 2011, Clin Child Psychol Psychiatry, V16, P89, DOI 10.1177/1359104509355019
   Drahota A, 2011, J AUTISM DEV DISORD, V41, P257, DOI 10.1007/s10803-010-1037-4
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Ford T, 2008, J CHILD PSYCHOL PSYC, V49, P900, DOI 10.1111/j.1469-7610.2008.01927.x
   Ford T, 2003, J AM ACAD CHILD PSY, V42, P1203, DOI 10.1097/01.chi.0000081820.25107.ae
   Greenaway R, 2010, J AUTISM DEV DISORD, V40, P1179, DOI 10.1007/s10803-010-0977-z
   Guy W, 1976, ECDEU ASSESSMENT MAN, P218
   Hedges DW, 2009, HUM PSYCHOPHARM CLIN, V24, P35, DOI 10.1002/hup.989
   Jamieson R, 2012, THESIS NEWCASTLE U N
   Julious SA, 2005, PHARM STAT, V4, P287, DOI 10.1002/pst.185
   Kazdin AE, 2001, CLIN PSYCHOL-SCI PR, V8, P143, DOI 10.1093/clipsy/8.2.143
   Kim-Cohen J, 2003, ARCH GEN PSYCHIAT, V60, P709, DOI 10.1001/archpsyc.60.7.709
   Lancaster GA, 2004, J EVAL CLIN PRACT, V10, P307, DOI 10.1111/j..2002.384.doc.x
   Liber JM, 2008, J CHILD PSYCHOL PSYC, V49, P886, DOI 10.1111/j.1469-7610.2008.01877.x
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lyneham HJ, 2007, J AM ACAD CHILD PSY, V46, P731, DOI 10.1097/chi.0b013e318046a09
   MacNeil BM, 2009, RES AUTISM SPECT DIS, V3, P1, DOI 10.1016/j.rasd.2008.06.001
   Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
   Medical Research Council, 2008, DEV EVALUATING COMPL
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Milne DL, 1999, J BEHAV THER EXP PSY, V30, P81, DOI 10.1016/S0005-7916(99)00011-7
   Moree BN, 2010, RES AUTISM SPECT DIS, V4, P346, DOI 10.1016/j.rasd.2009.10.015
   Murray L, 2009, PSYCHOL MED, V39, P1413, DOI 10.1017/S0033291709005157
   Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
   Ozsivadjian Ann, 2011, Clin Child Psychol Psychiatry, V16, P203, DOI 10.1177/1359104511404749
   Palinkas LA, 2011, ADM POLICY MENT HLTH, V38, P44, DOI 10.1007/s10488-010-0314-z
   Reaven J, 2011, BRAIN RES, V1380, P255, DOI 10.1016/j.brainres.2010.09.075
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   Rodgers J, 2012, J AUTISM DEV DISORD, V42, P2404, DOI 10.1007/s10803-012-1531-y
   Roth A. D., 2007, COMPETENCES REQUIRED
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Silverman W. K., 1996, ANXIETY DISORDERS IN
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Spence SH, 2003, J ANXIETY DISORD, V17, P605, DOI 10.1016/S0887-6185(02)00236-0
   Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
   Spiker MA, 2012, AUTISM, V16, P306, DOI 10.1177/1362361311401763
   Sung M, 2011, CHILD PSYCHIAT HUM D, V42, P634, DOI 10.1007/s10578-011-0238-1
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   Wechsler D, 1999, WECHSLER ABBREVIATED
   White SW, 2013, J AUTISM DEV DISORD, V43, P382, DOI 10.1007/s10803-012-1577-x
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   White SW, 2012, J AUTISM DEV DISORD, V42, P1138, DOI 10.1007/s10803-011-1353-3
   Williams C, 2008, BEHAV COGN PSYCHOTH, V36, P675, DOI 10.1017/S1352465808004864
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 63
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 723
EP 732
DI 10.1177/1362361313488839
PG 10
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900011
PM 24101715
ER

PT J
AU Oner, P
   Oner, O
   Munir, K
AF Oner, Pinar
   Oner, Ozgur
   Munir, Kerim
TI Three-item Direct Observation Screen (TIDOS) for autism spectrum
   disorder
SO AUTISM
LA English
DT Article
DE autism; observation; screening; Social Communication Questionnaire
ID PERVASIVE DEVELOPMENTAL DISORDERS; SOCIAL COMMUNICATION QUESTIONNAIRE;
   HIGHER FUNCTIONING INDIVIDUALS; ADAPTIVE-BEHAVIOR SCALES;
   PRESCHOOL-CHILDREN; DIAGNOSTIC INTERVIEW; MODIFIED CHECKLIST; FOLLOW-UP;
   HIGH-RISK; TODDLERS
AB We compared ratings on the Three-Item Direct Observation Screen test for autism spectrum disorders completed by pediatric residents with the Social Communication Questionnaire parent reports as an augmentative tool for improving autism spectrum disorder screening performance. We examined three groups of children (18-60 months) comparable in age (18-24 month, 24-36 month, 36-60 preschool subgroups) and gender distribution: n = 86 with Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) autism spectrum disorders; n = 76 with developmental delay without autism spectrum disorders; and n = 97 with typical development. The Three-Item Direct Observation Screen test included the following (a) Joint Attention, (b) Eye Contact, and (c) Responsiveness to Name. The parent Social Communication Questionnaire ratings had a sensitivity of .73 and specificity of .70 for diagnosis of autism spectrum disorders. The Three-Item Direct Observation Screen test item Joint Attention had a sensitivity of .82 and specificity of .90, Eye Contact had a sensitivity of .89 and specificity of .91, and Responsiveness to Name had a sensitivity of .67 and specificity of .87. In the Three-Item Direct Observation Screen test, having at least one of the three items positive had a sensitivity of .95 and specificity of .85. Age, diagnosis of autism spectrum disorder, and developmental level were important factors affecting sensitivity and specificity. The results indicate that augmentation of autism spectrum disorder screening by observational items completed by trained pediatric-oriented professionals can be a highly effective tool in improving screening performance. If supported by future population studies, the results suggest that primary care practitioners will be able to be trained to use this direct procedure to augment screening for autism spectrum disorders in the community.
C1 [Oner, Pinar; Oner, Ozgur] Dr Sami Ulus Childrens Hosp, Child & Adolescent Psychiat Dept, Autism Ctr Excellence, TR-06100 Ankara, Turkey.
   [Munir, Kerim] Childrens Hosp Boston, Boston, MA USA.
   [Munir, Kerim] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
RP Oner, O (reprint author), Dr Sami Ulus Childrens Hosp, Dept Child & Adolescent Psychiat, TR-06100 Ankara, Turkey.
EM ozgur.oner@yahoo.com
RI Munir, Kerim/D-6910-2015
OI Munir, Kerim/0000-0002-2404-1806
CR Allen CW, 2007, J AUTISM DEV DISORD, V37, P1272, DOI 10.1007/s10803-006-0279-7
   Alpas B, 2003, TURK PSIKOL DERG, V18, P57
   Al-Qabandi M, 2011, PEDIATRICS, V128, pE211, DOI 10.1542/peds.2010-1881
   Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
   BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
   Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470
   Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
   Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093
   Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
   Chawarska K, 2003, CHILD DEV, V74, P1108, DOI 10.1111/1467-8624.00595
   Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
   Dawson G, 2011, CURR OPIN PEDIATR, V23, P616, DOI 10.1097/MOP.0b013e32834cf082
   Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
   Fombonne E, 2001, J AM ACAD CHILD PSY, V40, P820, DOI 10.1097/00004583-200107000-00017
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Lee LC, 2007, RES AUTISM SPECT DIS, V1, P126, DOI 10.1016/j.rasd.2006.08.004
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
   Maestro S, 2006, ACTA PSYCHIAT SCAND, V113, P68, DOI 10.1111/j.1600-0447.2005.00695.x
   Mundy P, 1997, MENT RETARD DEV D R, V3, P343
   Oner P, 2012, KLIN PSIKOFARMAKOL B, V22, P43, DOI 10.5455/bcp.20111212091514
   Oosterling I, 2010, J CHILD PSYCHOL PSYC, V51, P1260, DOI 10.1111/j.1469-7610.2010.02246.x
   Oosterling IJ, 2009, J AUTISM DEV DISORD, V39, P897, DOI 10.1007/s10803-009-0692-9
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Rogers S. J., 2000, AUTISM SPECTRUM DISO, P79
   Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6
   Siegel B., 2004, PERVASIVE DEV DISORD
   Snow AV, 2008, AUTISM, V12, P627, DOI 10.1177/1362361308097116
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Tidmarsh L, 2003, CAN J PSYCHIAT, V48, P517
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 39
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 733
EP 742
DI 10.1177/1362361313487028
PG 10
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900012
PM 24126869
ER

PT J
AU Sullivan, JC
   Miller, LJ
   Nielsen, DM
   Schoen, SA
AF Sullivan, Jillian C.
   Miller, Lucy J.
   Nielsen, Darcy M.
   Schoen, Sarah A.
TI The presence of migraines and its association with sensory
   hyperreactivity and anxiety symptomatology in children with autism
   spectrum disorder
SO AUTISM
LA English
DT Article
DE anxiety; autism; hyperreactivity; migraines; sensory processing
ID OVER-RESPONSIVITY; SYMPTOMS
AB Migraine headaches are associated with sensory hyperreactivity and anxiety in the general population, but it is unknown whether this is also the case in autism spectrum disorders. This pilot study asked parents of 81 children (aged 7-17 years) with autism spectrum disorders to report their child's migraine occurrence, sensory hyperreactivity (Sensory Over-Responsivity Inventory), and anxiety symptoms (Spence Child Anxiety Scale). Children with autism spectrum disorders who experienced migraine headaches showed greater sensory hyperreactivity and anxiety symptomatology (p < 0.01; medium effect size for both) than those without migraines. Sensory hyperreactivity and anxiety symptomatology were additionally correlated (rho = 0.31, p = 0.005). This study provides preliminary evidence for a link between migraine headaches, sensory hyperreactivity, and anxiety symptomatology in autism spectrum disorders, which may suggest strategies for subtyping and exploring a common pathogenesis.
C1 [Sullivan, Jillian C.; Miller, Lucy J.; Nielsen, Darcy M.; Schoen, Sarah A.] Sensory Proc Disorder Fdn, Greenwood Village, CO 80111 USA.
   [Miller, Lucy J.; Schoen, Sarah A.] Rocky Mt Univ Hlth Profess, Provo, UT USA.
   [Miller, Lucy J.] Univ Colorado Denver, Denver, CO USA.
RP Sullivan, JC (reprint author), Sensory Proc Disorder Fdn, 5420 S Quebec St,Suite 135, Greenwood Village, CO 80111 USA.
EM jillian.sullivan@cantab.net
CR Allison C, 2012, J AM ACAD CHILD PSY, V51, P202, DOI 10.1016/j.jaac.2011.11.003
   Arruda MA, 2012, CEPHALALGIA, V32, P1093, DOI 10.1177/0333102412454226
   BLAU JN, 1985, J NEUROL, V232, P275, DOI 10.1007/BF00313864
   Casanova MF, 2008, MED HYPOTHESES, V70, P73, DOI 10.1016/j.mehy.2007.04.025
   Gargus JJ, 2009, ANN NY ACAD SCI, V1151, P133, DOI 10.1111/j.1749-6632.2008.03572.x
   Goadsby PJ, 2007, TRENDS MOL MED, V13, P39, DOI 10.1016/j.molmed.2006.11.005
   Green SA, 2010, J AUTISM DEV DISORD, V40, P1495, DOI 10.1007/s10803-010-1007-x
   Kinnealey M., 1999, OCCUPATIONAL THERAPY, V6, P195, DOI DOI 10.1002/OTI.97
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Lane SJ, 2012, AM J OCCUP THER, V66, P595, DOI 10.5014/ajot.2012.004523
   Riva G, 2003, CYBERPSYCHOL BEHAV, V6, P73, DOI 10.1089/109493103321167983
   Schoen SA, 2008, AM J OCCUP THER, V62, P393
   SELBY G, 1960, J NEUROL NEUROSUR PS, V23, P23, DOI 10.1136/jnnp.23.1.23
   Spence SH, 2003, J ANXIETY DISORD, V17, P605, DOI 10.1016/S0887-6185(02)00236-0
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Zohsel K, 2006, PAIN, V123, P10, DOI 10.1016/j.pain.2005.12.015
NR 16
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD AUG
PY 2014
VL 18
IS 6
BP 743
EP 747
DI 10.1177/1362361313489377
PG 5
WC Psychology, Developmental
SC Psychology
GA AQ2SE
UT WOS:000342637900013
PM 24072661
ER

PT J
AU Cidav, Z
   Marcus, SC
   Mandell, DS
AF Cidav, Zuleyha
   Marcus, Steven C.
   Mandell, David S.
TI Home- and Community-Based Waivers for Children With Autism: Effects on
   Service Use and Costs
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Medicaid; outpatient care; inpatient/long-term
   care; home- and community-based waivers
ID HEALTH-CARE EXPENDITURES; LONG-TERM CARE; MEDICAID HOME; SPECTRUM
   DISORDERS; PROGRAM; DIAGNOSIS; CLAIMS; STATES
AB We examined (a) the associations between Medicaid home and community-based waiver participation and service use and expenditures among children with ASD; and (b) how states' waiver spending moderates these effects. We used 2005 Medicaid claims to identify a sample of children with autism spectrum disorder (ASD). We selected two comparison groups who had no waiver participation: (a) children who were eligible for Medicaid through disability (disability group), and (b) children who had at least one inpatient/long-term care (IP/LT) episode (IP/LT group). Waiver participants were less likely to use IP/LT services and had lower associated expenditures than the disability group. As states' waiver spending increased, waiver participants became increasingly less likely to use IP/LT services. Waiver participants had more outpatient visits and associated expenditures; this difference increased as state waiver spending increased. Compared with the IP/LT group, waiver participants had lower IP/LT expenditures, more outpatient visits, and associated expenditures. Higher state waiver generosity increased this effect on outpatient visits and expenditures.
C1 [Cidav, Zuleyha; Marcus, Steven C.; Mandell, David S.] Univ Penn, Philadelphia, PA 19104 USA.
RP Cidav, Z (reprint author), Univ Penn, 3535 Market St, Philadelphia, PA 19104 USA.
EM zcidav@upenn.edu
RI Mandell, David/H-2730-2012
OI Mandell, David/0000-0001-8240-820X
CR Amaral MM, 2010, HEALTH CARE MANAG SC, V13, P319, DOI 10.1007/s10729-010-9132-9
   Anderson K, 2004, SOUTH ECON J, V71, P60, DOI 10.2307/4135310
   Anderson KH, 1997, MED CARE, V35, P425, DOI 10.1097/00005650-199705000-00002
   [Anonymous], 2011, REP STAT SERV IND AU
   [Anonymous], NAT RES INF SYST PRO
   [Anonymous], STAT STAT DEV DIS
   Aten B., 2011, SURVEY CURRENT BUSIN
   Burke JP, 2014, AUTISM, V18, P321, DOI 10.1177/1362361312467709
   Centers for Disease Control, 2013, AUT SPECTR DIS DAT S
   Coburn A F, 1990, Health Care Financ Rev, V11, P43
   Eskow K, 2011, J POLICY PRACT INTEL, V8, P28, DOI 10.1111/j.1741-1130.2011.00284.x
   Farmer EMZ, 2004, CHILD ADOL PSYCH CL, V13, P857, DOI 10.1016/j.chc.2004.04.004
   Fox MH, 2004, FAM COMMUNITY HEALTH, V27, P37
   Ganz M., 2006, UNDERSTANDING AUTISM
   HALVORSEN R, 1980, AM ECON REV, V70, P474
   Harrington C, 2000, GERONTOLOGIST, V40, P673
   HUGHES SL, 1985, HEALTH SERV RES, V20, P461
   Kaiser Family Foundation, 2007, US WAIT LISTS MED 19
   Kitchener M, 2003, INQUIRY-J HEALTH CAR, V40, P375
   Kitchener Martin, 2004, Home Health Care Serv Q, V23, P55, DOI 10.1300/J027v23n02_04
   Konetzka RT, 2012, HEALTH AFFAIR, V31, P1167, DOI 10.1377/hlthaff.2011.0902
   LAUDICINA SS, 1988, J HEALTH POLIT POLIC, V13, P525, DOI 10.1215/03616878-13-3-525
   LeBlanc AJ, 2000, HEALTH CARE FINANC R, V22, P159
   Levy SE, 2010, J DEV BEHAV PEDIATR, V31, P267, DOI 10.1097/DBP.0b013e3181d5d03b
   LURIE N, 1992, HOSP COMMUNITY PSYCH, V43, P69
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Medicaid program; Home and community-based services-HCFA. Final rule, 1985, FED REG, V50, P10013
   Medicode, 1987, INT CLASS DIS
   Peacock G, 2012, J DEV BEHAV PEDIATR, V33, P2, DOI 10.1097/DBP.0b013e31823969de
   Rizzolo MC, 2013, INTELLECT DEV DISAB, V51, P1, DOI 10.1352/1934-9556-51.01.001
   Shattuck PT, 2009, PSYCHIAT SERV, V60, P549, DOI 10.1176/appi.ps.60.4.549
   Solhkhah R, 2007, PSYCHIAT QUART, V78, P211, DOI 10.1007/s11126-007-9042-2
   Spearman RC, 2001, J HEAD TRAUMA REHAB, V16, P47, DOI 10.1097/00001199-200102000-00007
   Spigel S., 2007, MED AUTISM WAIVERS S
   U.S. Department of Health and Human Services Office of Inspector General (USDHHS), 2009, MED MAN CAR ENC DAT
   Van Houtven CH, 2005, INQUIRY-J HEALTH CAR, V42, P43
   Wang L, 2010, J AM ACAD CHILD PSY, V49, P1165, DOI 10.1016/j.jaac.2010.08.003
   WEISSERT WG, 1985, HEALTH SERV RES, V20, P423
NR 38
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
EI 1934-9556
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD AUG
PY 2014
VL 52
IS 4
BP 239
EP 248
DI 10.1352/1934-9556-52.4.239
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AQ3VW
UT WOS:000342722600001
PM 25061768
ER

PT J
AU Mehling, MH
   Tasse, MJ
AF Mehling, Margaret H.
   Tasse, Marc J.
TI Empirically Derived Model of Social Outcomes and Predictors for Adults
   With ASD
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism Spectrum Disorder; social outcomes; community inclusion; social
   relationships; friendships; choice; access to services; social
   determination; National Core Indicators
ID RECEPTIVE LANGUAGE DISORDER; AUTISM SPECTRUM DISORDERS; QUALITY-OF-LIFE;
   FOLLOW-UP; DISABILITIES; ADOLESCENCE; CHILDHOOD; CHILDREN
AB This study used data from the National Core Indicators (NCI) Survey to derive an empirically validated measurement model for social outcomes and associated constructs for both individuals with Autism Spectrum Disorder (ASD) and individuals with other disabilities. Items consistent with the survey structure of the NCI were selected as initial indicators of the latent constructs Social Relationships, Community Inclusion, and Opportunity for Choice in factor analyses. Results yielded a novel factor structure that is different from the original NCI survey structure. Three factors emerged as a result of these analyses: Personal Control, Social Determination, and Social Participation and Relationships. The factor structure of each of these constructs was consistent although not identical across individuals with ASD and individuals with developmental disabilities other than ASD.
C1 [Mehling, Margaret H.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Tasse, Marc J.] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
RP Mehling, MH (reprint author), Ohio State Univ, Dept Psychol, Nisonger Ctr, McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM mehling.19@osu.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Billstedt E, 2011, AUTISM, V15, P7, DOI 10.1177/1362361309346066
   Centers for Disease Control and Prevention, 2012, MORBIDITY MORTALITY, V61, P2
   Curran PJ, 1996, PSYCHOL METHODS, V1, P16, DOI 10.1037/1082-989X.1.1.16
   Dimitrov Dimiter M, 2006, Work, V26, P429
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Glass G. V., 1981, METAANALYSIS SOCIAL
   Heller T, 2002, MENT RETARD, V40, P366, DOI 10.1352/0047-6765(2002)040<0366:EYFUOT>2.0.CO;2
   Howlin P., 2005, HDB AUTISM PERVASIVE, V1, P201
   Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
   Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Human Services Research Institute & National Association of State Directors of Developmental Disabilities Services, 2011, NAT COR IND AD CONS
   Human Services Research Institute & National Association of State Directors of Developmental Disabilities Services, 2012, NAT COR IND AD CONS
   IBM Corp released, 2011, IBM SPSS STAT WIND V
   IBM Corporation, 2012, IBM SPSS AM WIND VER
   Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
   LITTLE RJA, 1989, SOCIOL METHOD RES, V18, P292, DOI 10.1177/0049124189018002004
   Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
   Mulaik SA, 2010, FDN FACTOR ANAL
   MUTHEN B, 1985, BRIT J MATH STAT PSY, V38, P171
   MUTHEN B, 1987, PSYCHOMETRIKA, V52, P431, DOI 10.1007/BF02294365
   Neely-Barnes S, 2008, INTELLECT DEV DISAB, V46, P12, DOI 10.1352/0047-6765(2008)46[12:DCIQOL]2.0.CO;2
   Nordin V, 1998, ACTA PSYCHIAT SCAND, V97, P99, DOI 10.1111/j.1600-0447.1998.tb09970.x
   Ruble L. A., 1996, FOCUS AUTISM OTHER D, V11, P3
   Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
   Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
   Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
   Venter A., 1992, HIGH FUNCTIONING IND, P187
   Whitehouse AJO, 2009, INT J LANG COMM DIS, V44, P511, DOI 10.1080/13682820802708098
NR 31
TC 1
Z9 1
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
EI 1934-9556
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD AUG
PY 2014
VL 52
IS 4
BP 282
EP 295
DI 10.1352/1934-9556-52.4.282
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AQ3VW
UT WOS:000342722600005
PM 25061772
ER

PT J
AU Wehman, P
   Chan, F
   Ditchman, N
   Kang, HJ
AF Wehman, Paul
   Chan, Fong
   Ditchman, Nicole
   Kang, Hyun-Ju
TI Effect of Supported Employment on Vocational Rehabilitation Outcomes of
   Transition-Age Youth With Intellectual and Developmental Disabilities: A
   Case Control Study
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE supported employment; intellectual disability; developmental disability;
   vocational rehabilitation; propensity score matching
ID AUTISM SPECTRUM DISORDER; YOUNG-ADULTS; EXPERIENCES; SERVICES; SCHOOL;
   WORK
AB The purpose of this study was to examine the effect of supported employment intervention on the employment outcomes of transition-age youth with intellectual and developmental disabilities served by the public vocational rehabilitation system using a case-control study design. Data for this study were extracted from the Rehabilitation Services Administration Case Service Report (RSA911) database for fiscal year 2009. The sample included 23,298 youth with intellectual and developmental disabilities aged between 16 and 25 years old at the time of application. The classification and regression tree (CART) method was used to estimate propensity scores and to adjust for selection bias on the basis of all prominent covariates relevant to the dependent variable (i.e., competitive employment). Results yielded six homogeneous subgroups, and receipt of supported employment was found to increase the employment rates across all of the groups. The effect of supported employment was especially strong for youth who were Social Security beneficiaries, special education students, and individuals with intellectual disabilities or autism who were high school graduates. These findings suggest that supported employment is an effective service for enhancing the vocational rehabilitation outcomes of young adults and provides valuable information for policy makers, health care providers, rehabilitation counselors, and educators.
C1 [Wehman, Paul] Virginia Commonwealth Univ, Dept Phys Med & Rehabil, Richmond, VA 23284 USA.
   [Chan, Fong] Univ Wisconsin Madison, Rehabil Res & Training Ctr Evidence Based Vocat R, Madison, WI USA.
   [Ditchman, Nicole] IIT, Dept Psychol, Chicago, IL 60616 USA.
   [Kang, Hyun-Ju] Univ Wisconsin Madison, Dept Rehabil Psychol & Special Educ, Madison, WI USA.
RP Wehman, P (reprint author), Virginia Commonwealth Univ, Med Coll Virginia, 1314 W Main St, Richmond, VA 23284 USA.
EM pwehman@vcu.org
CR Austin PC, 2011, MULTIVAR BEHAV RES, V46, P399, DOI 10.1080/00273171.2011.568786
   Bolton B, 2004, SPR S REHAB, P444
   Bond GR, 2004, PSYCHIATR REHABIL J, V27, P345, DOI 10.2975/27.2004.345.359
   Bond GR, 2008, PSYCHIATR REHABIL J, V31, P280, DOI 10.2975/31.4.2008.280.290
   Brault MW, 2012, CURRENT POPULATION R, VP70-131
   Campbell K, 2011, SCHIZOPHRENIA BULL, V37, P370, DOI 10.1093/schbul/sbp066
   Carter EW, 2011, INTELLECT DEV DISAB, V49, P233, DOI 10.1352/1934-9556-49.4.233
   Carter EW, 2012, J DISABIL POLICY STU, V23, P50, DOI 10.1177/1044207311414680
   Certo NJ, 2008, RES PRACT PERS SEV D, V33, P85
   Chan Y. C., REHABILITATION COUNS
   Cimera RE, 2013, RES PRACT PERS SEV D, V38, P88
   Cook J. A., 2006, J VOCATIONAL REHABIL, V25, P71, DOI DOI 10.1037/T05056-000
   Dehejia RH, 2002, REV ECON STAT, V84, P151, DOI 10.1162/003465302317331982
   Ditchman N., 2013, CAREER DEV EMPLOYMEN, P343
   Dutta A, 2008, J OCCUP REHABIL, V18, P326, DOI 10.1007/s10926-008-9154-z
   Fan XT, 2011, GIFTED CHILD QUART, V55, P74, DOI 10.1177/0016986210390635
   Fonarow GC, 2005, JAMA-J AM MED ASSOC, V293, P572, DOI 10.1001/jama.293.5.572
   Fraker T, 2009, J VOCATIONAL REHABIL, V30, P223
   Graham C., 2013, J VOCATIONAL REHABIL, V39, P75
   Guo S., 2010, PROPENSITY SCORE ANA
   Hendricks DR, 2009, FOCUS AUTISM DEV DIS, V24, P77, DOI 10.1177/1088357608329827
   Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
   Lee BK, 2010, STAT MED, V29, P337, DOI 10.1002/sim.3782
   Lewis R.J., 2000, ANN M SOC AC EM MED
   Luciano AE, 2014, J VOCATIONAL REHABIL, V40, P1
   Luellen JK, 2005, EVALUATION REV, V29, P530, DOI 10.1177/0193841X05275596
   Martin R., 2010, AM REHABILITATIO SUM, P15
   Migliore A, 2008, REHABIL COUNS BULL, V52, P35, DOI 10.1177/0034355208320075
   Olshen R., 1984, CLASSIFICATION REGRE, V1st
   Ottomanelli L, 2012, ARCH PHYS MED REHAB, V93, P740, DOI 10.1016/j.apmr.2012.01.002
   Patil D. D., 2010, INT J COMPUTER APPL, V11, P23, DOI 10.5120/1554-2074
   Research Triangle Institute International, 2002, 1 RES TRIANGL I INT
   Roux AM, 2013, J AM ACAD CHILD PSY, V52, P931, DOI 10.1016/j.jaac.2013.05.019
   RUSCH FR, 1989, J APPL BEHAV ANAL, V22, P351, DOI 10.1901/jaba.1989.22-351
   Statistical Package for the Social Sciences, 1999, SPSS ANSWERTREE ALG
   U. S. Bureau of Labor Statistics, 2013, USDL131141 US BUR LA
   U. S. Government Accountability Office, 2005, GAO05865
   Wehman P, 2005, J HEAD TRAUMA REHAB, V20, P115, DOI 10.1097/00001199-200503000-00001
   Wehman P, 2014, J DISABIL POLICY STU, V25, P30, DOI 10.1177/1044207313518071
   Wehman P., 2014, PREDICTORS SUC UNPUB
   Wehman P., 2012, RES PRACT PERS SEV D, V37, P1
   Wehman P, 1981, COMPETITIVE EMPLOYME
   Wehman P., 2007, REAL WORK REAL PAY I
   Wehman P., 1997, SUPPORTED EMPLOYMENT
   WEHMAN PH, 1991, ARCH PHYS MED REHAB, V72, P101
   Zhang H, 1999, RECURSIVE PARTITIONI
NR 46
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
EI 1934-9556
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD AUG
PY 2014
VL 52
IS 4
BP 296
EP 310
DI 10.1352/1934-9556-52.4.296
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AQ3VW
UT WOS:000342722600006
PM 25061773
ER

PT J
AU Seltzer, LE
   Ma, MD
   Ahmed, S
   Bertrand, M
   Dobyns, WB
   Wheless, J
   Paciorkowski, AR
AF Seltzer, Laurie E.
   Ma, Mandy
   Ahmed, Sohnee
   Bertrand, Mary
   Dobyns, William B.
   Wheless, James
   Paciorkowski, Alex R.
TI Epilepsy and outcome in FOXG1-related disorders
SO EPILEPSIA
LA English
DT Article
DE FOXG1; 14q12; Infantile spasms; Epilepsy; Developmental outcome
ID RETT-SYNDROME; INFANTILE SPASMS; MENTAL-RETARDATION; CONGENITAL VARIANT;
   FOXG1; PHENOTYPE; ENCEPHALOPATHIES; GENOTYPE; 14Q12; TELENCEPHALON
AB Objective: FOXG1-related disorders are associated with severe intellectual disability, absent speech with autistic features, and epilepsy. Children with deletions or intragenic mutations of FOXG1 also have postnatal microcephaly, morphologic abnormalities of the corpus callosum, and choreiform movements. Duplications of 14q12 often present with infantile spasms, and have subsequent intellectual disability with autistic features. Long-term epilepsy outcome and response to treatment have not been studied systematically in a well-described cohort of subjects with FOXG1-related disorders. We report on the epilepsy features and developmental outcome of 23 new subjects with deletions or intragenic mutations of FOXG1, and 7 subjects with duplications.
   Methods: Subjects had either chromosomal microarray or FOXG1 gene sequencing performed as part of routine clinical care. Development and epilepsy follow-up data were collected from medical records from treating neurologists and through telephone parental interviews using standardized questionnaires.
   Results: Epilepsy was diagnosed in 87% of the subjects with FOXG1-related disorders. The mean age of epilepsy diagnosis in FOXG1 duplications was significantly younger than those with deletions/intragenic mutations (p = 0.0002). All of the duplication FOXG1 children with infantile spasms responded to hormonal therapy, and only one required long-term antiepileptic therapy. In contrast, more children with deletions/intragenic mutations required antiepileptic drugs on follow-up (p < 0.0005). All subjects with FOXG1-related disorders had neurodevelopmental disabilities after 3 years of age, regardless of the epilepsy type or intractability of seizures. All had impaired verbal language and social contact, and three duplication subjects were formally diagnosed with autism. Subjects with deletion/intragenic mutations, however, had significantly worse ambulation (p = 0.04) and functional hand use (p < 0.0005).
   Significance: Epilepsy and developmental outcome characteristics allow clinicians to distinguish among the FOXG1-related disorders. Further genotype-phenotype studies of FOXG1 may help to elucidate why children develop different forms of developmental epilepsy.
C1 [Seltzer, Laurie E.; Ahmed, Sohnee; Paciorkowski, Alex R.] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
   [Ma, Mandy; Bertrand, Mary] Washington Univ, Pediat Epilepsy Ctr, Dept Neurol, St Louis, MO USA.
   [Bertrand, Mary] Washington Univ, Dept Pediat, Pediat Epilepsy Ctr, St Louis, MO 63130 USA.
   [Dobyns, William B.] Univ Washington, Ctr Integrat Brain Res, Seattle Res Inst, Dept Neurol, Seattle, WA 98195 USA.
   [Dobyns, William B.] Univ Washington, Ctr Integrat Brain Res, Seattle Res Inst, Div Genet Med,Dept Pediat, Seattle, WA 98195 USA.
   [Wheless, James] LeBonheur Childrens Hosp, Memphis, TN USA.
   [Wheless, James] Univ Tennessee, Memphis, TN USA.
   [Paciorkowski, Alex R.] Univ Rochester, Med Ctr, Ctr Neural Dev & Dis, Dept Pediat, Rochester, NY 14642 USA.
   [Paciorkowski, Alex R.] Univ Rochester, Med Ctr, Ctr Neural Dev & Dis, Dept Biomed Genet, Rochester, NY 14642 USA.
RP Paciorkowski, AR (reprint author), Univ Rochester, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM Alex_Paciorkowski@urmc.rochester.edu
FU National Institute of Neurological Disorders and Stroke (NINDS) of the
   National Institutes of Health (NIH) [K12NS066098, R01NS058721]; Child
   Neurology Foundation;  [K08NS078054]
FX We wish to acknowledge the FOXG1 Foundation for referring subjects to
   this study. Research reported in this publication was supported by the
   National Institute of Neurological Disorders and Stroke (NINDS) of the
   National Institutes of Health (NIH) under award numbers K12NS066098 (to
   L. E. S.) R01NS058721 (to W. B. D.), the Child Neurology Foundation
   Logan Infantile Spasms Award (to A. R. P), and K08NS078054 (to A.R.P.).
CR Ahlgren S, 2003, J NEUROBIOL, V57, P337, DOI 10.1002/neu.10287
   Ariani F, 2008, AM J HUM GENET, V83, P89, DOI 10.1016/j.ajhg.2008.05.015
   Bahi-Buisson N, 2010, NEUROGENETICS, V11, P241, DOI 10.1007/s10048-009-0220-2
   Bertossi Chiara, 2014, Brain Dev, V36, P402, DOI 10.1016/j.braindev.2013.06.008
   Brancaccio M, 2010, STEM CELLS, V28, P1206, DOI 10.1002/stem.443
   Brunetti-Pierri N, 2011, EUR J HUM GENET, V19, P102, DOI 10.1038/ejhg.2010.142
   Cardoza B, 2011, SEIZURE-EUR J EPILEP, V20, P646, DOI 10.1016/j.seizure.2011.06.010
   Colombo E, 2007, J NEUROSCI, V27, P4786, DOI 10.1523/JNEUSOCI.0417-07.2007
   Ellaway CJ, 2013, EUR J HUM GENET, V21, P522, DOI 10.1038/ejhg.2012.208
   Guerrini R, 2012, EPILEPSIA, V53, P2067, DOI 10.1111/j.1528-1167.2012.03656.x
   Halbach NSJ, 2012, AM J MED GENET A, V158A, P340, DOI 10.1002/ajmg.a.34418
   Hebert JM, 2008, NAT REV NEUROSCI, V9, P678, DOI 10.1038/nrn2463
   Kamien BA, 2012, J CLIN NEUROSCI, V19, P934, DOI 10.1016/j.jocn.2012.01.017
   Karvelas G, 2009, SEIZURE-EUR J EPILEP, V18, P197, DOI 10.1016/j.seizure.2008.09.006
   Kortum F, 2011, J MED GENET, V48, P396, DOI 10.1136/jmg.2010.087528
   Kumakura A, 2013, BRAIN DEV, V36, P725
   Mastrangelo M, 2012, PEDIATR NEUROL, V46, P24, DOI 10.1016/j.pediatrneurol.2011.11.003
   Mencarelli MA, 2010, J MED GENET, V47, P49, DOI 10.1136/jmg.2009.067884
   Paciorkowski AR, 2011, PEDIATR NEUROL, V45, P355, DOI 10.1016/j.pediatrneurol.2011.08.010
   Paciorkowski AR, 2011, EUR J HUM GENET, V19, P1238, DOI 10.1038/ejhg.2011.121
   Paciorkowski AR, 2013, NEUROGENETICS, V14, P99, DOI 10.1007/s10048-013-0356-y
   Partikian A, 2010, J CHILD NEUROL, V25, P423, DOI 10.1177/0883073809341664
   Riikonen RS, 2010, EUR J PAEDIATR NEURO, V14, P13, DOI 10.1016/j.ejpn.2009.03.004
   Striano P, 2011, NEUROLOGY, V76, P1600, DOI 10.1212/WNL.0b013e3182194bbf
   Yeung A, 2009, EUR J MED GENET, V52, P440, DOI 10.1016/j.ejmg.2009.09.004
   Yu FH, 2006, NAT NEUROSCI, V9, P1142, DOI 10.1038/nn1754
NR 26
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
EI 1528-1167
J9 EPILEPSIA
JI Epilepsia
PD AUG
PY 2014
VL 55
IS 8
BP 1292
EP 1300
DI 10.1111/epi.12648
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA AP7CW
UT WOS:000342236400024
PM 24836831
ER

PT J
AU Wegbreit, E
   Cushman, GK
   Puzia, ME
   Weissman, AB
   Kim, KL
   Laird, AR
   Dickstein, DP
AF Wegbreit, Ezra
   Cushman, Grace K.
   Puzia, Megan E.
   Weissman, Alexandra B.
   Kim, Kerri L.
   Laird, Angela R.
   Dickstein, Daniel P.
TI Developmental Meta-analyses of the Functional Neural Correlates of
   Bipolar Disorder
SO JAMA PSYCHIATRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; VOXEL-BASED MORPHOMETRY; FALSE DISCOVERY
   RATE; RESPONSE-INHIBITION; FACIAL EXPRESSIONS; MOTOR INHIBITION; ALE
   METAANALYSIS; NATIONAL TRENDS; FOLLOW-UP; BRAIN
AB IMPORTANCE Bipolar disorder (BD) is a debilitating mental illness associated with high costs to diagnosed individuals and society. Within the past 2 decades, increasing numbers of children and adolescents have been diagnosed as having BD. While functional magnetic resonance imaging (fMRI) studies have begun to investigate the neural mechanisms underlying BD, few have directly compared differences in youths with BD and adults with BD (hereafter BD-youths and BD-adults, respectively).
   OBJECTIVE To test the hypothesis that BD-youths (<18 years old) would show greater convergence of amygdala hyperactivation and prefrontal cortical hypoactivation vs BD-adults.
   DATA SOURCES PubMed and PsycINFO databases were searched on July 17, 2013, for original, task-related coordinate-based fMRI articles.
   STUDY SELECTION In total, 21 pediatric studies, 73 adult studies, and 2 studies containing distinct pediatric and adult groups within the same study met inclusion criteria for our ALE analyses.
   DATA EXTRACTION AND SYNTHESIS Coordinates of significant between-group differences were extracted from each published study. Recent improvements in GingerALE software were used to perform direct comparisons of pediatric and adult fMRI findings. We conducted activation likelihood estimation (ALE) meta-analyses directly comparing the voxelwise convergence of fMRI findings in BD-youths vs BD-adults, both relative to healthy control (HC) participants.
   RESULTS Analyses of emotional face recognition fMRI studies showed significantly greater convergence of amygdala hyperactivation among BD-youths than BD-adults. More broadly, analyses of fMRI studies using emotional stimuli showed significantly greater convergence of hyperactivation among BD-youths than BD-adults in the inferior frontal gyrus and precuneus. In contrast, analyses of fMRI studies using nonemotional cognitive tasks and analyses aggregating emotional and nonemotional tasks showed significantly greater convergence of hypoactivation among BD-youths than BD-adults in the anterior cingulate cortex.
   CONCLUSIONS AND RELEVANCE Our data suggest that amygdala, prefrontal, and visual system hyperactivation is important in the emotional dysfunction present in BD-youths, as well as that anterior cingulate cortex hypoactivation is relevant to the cognitive deficits in BD-youths. Future studies are required to determine if the developmental fMRI differences between BD-youths and BD-adults identified by our ALE meta-analyses are useful as brain-based diagnostic or treatment markers of BD, including either longitudinal neuroimaging studies of BD-youths as they become adults or cross-sectional imaging studies directly comparing BD-youths with BD-adults.
C1 [Wegbreit, Ezra; Cushman, Grace K.; Puzia, Megan E.; Weissman, Alexandra B.; Kim, Kerri L.; Dickstein, Daniel P.] Brown Univ, Alpert Med Sch, Dept Psychiat & Human Behav, Pediat Mood Imaging & Neurodev Program, East Providence, RI 02915 USA.
   [Wegbreit, Ezra; Cushman, Grace K.; Puzia, Megan E.; Weissman, Alexandra B.; Kim, Kerri L.; Dickstein, Daniel P.] Bradley Hosp, East Providence, RI USA.
   [Laird, Angela R.] Florida Int Univ, Dept Phys, Miami, FL 33199 USA.
RP Wegbreit, E (reprint author), Brown Univ, Alpert Med Sch, Dept Psychiat & Human Behav, Pediat Mood Imaging & Neurodev Program, 1011 Vet Mem Pkwy, East Providence, RI 02915 USA.
EM ezra_wegbreit@brown.edu
FU National Institutes of Health [5T32-MH019927-20, R01-MH074457,
   R01-MH084812, 5R01-MH087513, 1R21-MH096850, 1R01-MH099703,
   5R01-MH092450]
FX Dr Wegbreit is supported by grant 5T32-MH019927-20 from the National
   Institutes of Health. Dr Laird is supported by grants R01-MH074457 and
   R01-MH084812 from the National Institutes of Health. Mss Cushman, Puzia,
   and Weissman and Drs Kim and Dickstein are supported by grants
   5R01-MH087513, 1R21-MH096850, 1R01-MH099703, and 5R01-MH092450 from the
   National Institutes of Health, although the present study was not part
   of any of these grants.
CR Adleman NE, 2013, PSYCHIAT RES-NEUROIM, V212, P161, DOI 10.1016/j.pscychresns.2013.01.006
   Adleman NE, 2012, J CHILD PSYCHOL PSYC, V53, P1149, DOI 10.1111/j.1469-7610.2012.02568.x
   Altshuler L, 2008, BIPOLAR DISORD, V10, P708, DOI 10.1111/j.1399-5618.2008.00617.x
   Arnsten AFT, 2012, J AM ACAD CHILD PSY, V51, P356, DOI 10.1016/j.jaac.2012.01.008
   Beesdo K, 2009, ARCH GEN PSYCHIAT, V66, P275, DOI 10.1001/archgenpsychiatry.2008.545
   Blader JC, 2007, BIOL PSYCHIAT, V62, P107, DOI 10.1016/j.biopsych.2006.11.006
   Blumberg HP, 2003, ARCH GEN PSYCHIAT, V60, P601, DOI 10.1001/archpsyc.60.6.601
   Brett M, 2002, NAT REV NEUROSCI, V3, P243, DOI 10.1038/nrn756
   Caetano SC, 2005, BIOL PSYCHIAT, V58, P525, DOI 10.1016/j.biopsych.2005.04.027
   Cavanna AE, 2006, BRAIN, V129, P564, DOI 10.1093/brain/awl004
   Chang K, 2004, ARCH GEN PSYCHIAT, V61, P781, DOI 10.1001/archpsyc.61.8.781
   Chen CH, 2011, BIPOLAR DISORD, V13, P1, DOI 10.1111/j.1399-5618.2011.00893.x
   Cortese S, 2012, AM J PSYCHIAT, V169, P1038, DOI 10.1176/appi.ajp.2012.11101521
   Costafreda Sergi G, 2009, Front Neuroinform, V3, P33, DOI 10.3389/neuro.11.033.2009
   Cromheeke S, 2013, BRAIN STRUCT FUNCT, DOI [10.1007/s00429-013-0549-z, DOI 10.1007/S00429-013-0549-Z]
   Delvecchio G, 2012, EUR NEUROPSYCHOPHARM, V22, P100, DOI 10.1016/j.euroneuro.2011.07.003
   Delvecchio G, 2013, PSYCHOL MED, V43, P553, DOI 10.1017/S0033291712001432
   Dickstein DP, 2010, BIPOLAR DISORD, V12, P707, DOI 10.1111/j.1399-5618.2010.00863.x
   Dickstein DP, 2005, ARCH GEN PSYCHIAT, V62, P734, DOI 10.1001/archpsyc.62.7.734
   Dickstein DP, 2013, J AM ACAD CHILD PSY, V52, P279, DOI 10.1016/j.jaac.2012.12.012
   Dickstein SG, 2006, J CHILD PSYCHOL PSYC, V47, P1051, DOI 10.1111/j.1469-7610.2006.01671.x
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Eickhoff SB, 2009, HUM BRAIN MAPP, V30, P2907, DOI 10.1002/hbm.20718
   Escamilla I, 2011, J AFFECT DISORDERS, V132, P270, DOI 10.1016/j.jad.2011.01.013
   Etkin A, 2011, TRENDS COGN SCI, V15, P85, DOI 10.1016/j.tics.2010.11.004
   Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
   Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158
   Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101
   Guyer AE, 2009, CHILD DEV, V80, P1000, DOI 10.1111/j.1467-8624.2009.01313.x
   Hajek T, 2009, J AFFECT DISORDERS, V115, P395, DOI 10.1016/j.jad.2008.10.007
   Hauser M, 2013, BIPOLAR DISORD, V15, P507, DOI 10.1111/bdi.12094
   Holtmann M, 2010, BIPOLAR DISORD, V12, P155, DOI 10.1111/j.1399-5618.2010.00794.x
   Houenou J, 2011, J AFFECT DISORDERS, V132, P344, DOI 10.1016/j.jad.2011.03.016
   Hulvershorn LA, 2012, BIOL PSYCHIAT, V71, P603, DOI 10.1016/j.biopsych.2011.10.038
   Hummer TA, 2013, BIOL PSYCHIAT, V73, P136, DOI 10.1016/j.biopsych.2012.06.036
   Hunt JI, 2013, J CLIN PSYCHIAT, V74, pE110, DOI 10.4088/JCP.12m07874
   Kalmar JH, 2009, J INT NEUROPSYCH SOC, V15, P476, DOI 10.1017/S1355617709090584
   Keck PE, 2008, J PSYCHIATR PRACT, V14, P31, DOI 10.1097/01.pra.0000320124.91799.2a
   Keenan-Miller D, 2012, J AM ACAD CHILD PSY, V51, P1085, DOI 10.1016/j.jaac.2012.08.005
   Keener MT, 2012, PSYCHOL MED, V42, P1913, DOI 10.1017/S0033291711002935
   Kim P, 2012, AM J PSYCHIAT, V169, P642, DOI 10.1176/appi.ajp.2012.11081245
   Kleinman LS, 2003, PHARMACOECONOMICS, V21, P601, DOI 10.2165/00019053-200321090-00001
   Kupferschmidt DA, 2011, PSYCHIAT RES-NEUROIM, V193, P71, DOI 10.1016/j.pscychresns.2011.02.011
   Laird Angela R, 2011, BMC Res Notes, V4, P349, DOI 10.1186/1756-0500-4-349
   Laird AR, 2005, HUM BRAIN MAPP, V25, P155, DOI 10.1002/hbm.20136
   Lancaster JL, 2007, HUM BRAIN MAPP, V28, P1194, DOI 10.1002/hbm.20345
   Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
   Leboyer M, 2005, BIPOLAR DISORD, V7, P111, DOI 10.1111/j.1399-5618.2005.00181.x
   Leibenluft E, 2007, AM J PSYCHIAT, V164, P52, DOI 10.1176/appi.ajp.164.1.52
   Malhi GS, 2007, BIPOLAR DISORD, V9, P345, DOI 10.1111/j.1399-5618.2007.00485.x
   Mana S, 2010, EUR PSYCHIAT, V25, P345, DOI 10.1016/j.eurpsy.2010.04.010
   McGurk SR, 2007, AM J PSYCHIAT, V164, P437, DOI 10.1176/appi.ajp.164.3.437
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Milham MP, 2005, BIOL PSYCHIAT, V57, P961, DOI 10.1016/j.biopsych.2005.01.0383
   Moreno C, 2007, ARCH GEN PSYCHIAT, V64, P1032, DOI 10.1001/archpsyc.64.9.1032
   Pavuluri MN, 2009, J AM ACAD CHILD PSY, V48, P308, DOI 10.1097/CHI.0b013e3181948fc7
   Pavuluri MN, 2009, J AM ACAD CHILD PSY, V48, P299, DOI 10.1097/CHI.0b013e318196b907
   Rich BA, 2006, P NATL ACAD SCI USA, V103, P8900, DOI 10.1073/pnas.0603246103
   Rizzo CJ, 2007, BIPOLAR DISORD, V9, P839
   Scott EM, 2013, J AFFECT DISORDERS, V144, P208, DOI 10.1016/j.jad.2012.06.031
   Strakowski SM, 2004, NEUROPSYCHOPHARMACOL, V29, P1734, DOI 10.1038/sj.npp.1300492
   Strakowski SM, 2011, BIOL PSYCHIAT, V69, P381, DOI 10.1016/j.biopsych.2010.09.019
   Strakowski SM, 2008, EARLY INTERV PSYCHIA, V2, P225, DOI 10.1111/j.1751-7893.2008.00082.x
   Turkeltaub PE, 2012, HUM BRAIN MAPP, V33, P1, DOI 10.1002/hbm.21186
   Usher J, 2010, PSYCHIAT RES-NEUROIM, V182, P1, DOI 10.1016/j.pscychresns.2009.09.004
   Van der Schot A, 2010, PSYCHIAT RES-NEUROIM, V184, P135, DOI 10.1016/j.pscychresns.2010.07.009
   Wager TD, 2007, SOC COGN AFFECT NEUR, V2, P150, DOI 10.1093/scan/nsm015
   Weathers J, 2013, PSYCHIAT RES-NEUROIM, V214, P56, DOI 10.1016/j.pscychresns.2013.05.002
   Weathers JD, 2012, AM J PSYCHIAT, V169, P633, DOI 10.1176/appi.ajp.2012.11081244
   Wegbreit E, 2012, ISR J PSYCHIATR REL, V49, P75
   Whalley HC, 2012, BIPOLAR DISORD, V14, P411, DOI 10.1111/j.1399-5618.2012.01016.x
   Wykes T, 2011, AM J PSYCHIAT, V168, P472, DOI 10.1176/appi.ajp.2010.10060855
   Young ME, 2013, J AFFECT DISORDERS, V150, P1096, DOI 10.1016/j.jad.2013.04.027
NR 74
TC 1
Z9 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD AUG
PY 2014
VL 71
IS 8
BP 926
EP 935
DI 10.1001/jamapsychiatry.2014.660
PG 10
WC Psychiatry
SC Psychiatry
GA AP0SP
UT WOS:000341774600011
PM 25100166
ER

PT J
AU Lyall, K
   Constantino, JN
   Weisskopf, MG
   Roberts, AL
   Ascherio, A
   Santangelo, SL
AF Lyall, Kristen
   Constantino, John N.
   Weisskopf, Marc G.
   Roberts, Andrea L.
   Ascherio, Alberto
   Santangelo, Susan L.
TI Parental Social Responsiveness and Risk of Autism Spectrum Disorder in
   Offspring
SO JAMA PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; GENERAL-POPULATION; SCALE SRS;
   DIAGNOSTIC INTERVIEW; TRAITS; SIBLINGS; TWIN; IMPAIRMENT; VALIDATION;
   RECURRENCE
AB IMPORTANCE Although autism spectrum disorder (ASD) is known to be heritable, patterns of inheritance of subclinical autistic traits in nonclinical samples are poorly understood.
   OBJECTIVE To examine the familiality of Social Responsiveness Scale (SRS) scores of individuals with and without ASD.
   DESIGN, SETTING, AND PARTICIPANTS We performed a nested case-control study (pilot study: July 1, 2007, through June 30,2009; full-scale study: September 15, 20 08, through September 14, 2012) within a population-based longitudinal cohort. Participants were drawn from the Nurses' Health Study II, a cohort of 116 430 female nurses recruited in 1989. Case participants were index children with reported ASD; control participants were frequency matched by year of birth of case participants among those not reporting ASD. Of 3161 eligible participants, 2144 nurses (67.8%) returned SRS forms for a child and at least 1 parent and were included in these analyses.
   EXPOSURE The SRS scores, as reported by nurse mothers and their spouses, were examined in association with risk of ASD using crude and adjusted logistic regression analyses. The SRS scores of the children were examined in association with SRS scores of the parents using crude and adjusted linear regression analyses stratified by case status.
   MAIN OUTCOMES AND MEASURES Autism spectrum disorder, assessed by maternal report, validated in a subgroup with the Autism Diagnostic Interview-Revised.
   RESULTS A total of 1649 individuals were included in these analyses, including 256 ASD case participants, 1393 control participants, 1233 mothers, and 1614 fathers. Risk of ASD was increased by 85.0% among children whose parents had concordantly elevated SRS scores (odds ratio [OR] 1.85; 95% CI, 1.08-3.16) and by 52.0% when the score of either parent was elevated (OR, 1.52; 95% CI, 1.11-2.06). Elevated scores of the father significantly increased the risk of ASD in the child (OR, 1.94; 95% CI, 1.38-2.71), but no association was seen with elevated scores of the mother. Elevated parent scores significantly increased child scores in controls, corresponding to an increase in 23 points (P < .001).
   CONCLUSIONS AND RELEVANCE These findings support the role of additive genetic influences in concentrating inherited ASD susceptibility in successive generations and the potential role of preferential mating, and suggest that typical variation in parental social functioning can produce clinically significant differences in offspring social traits.
C1 [Lyall, Kristen; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Lyall, Kristen] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Constantino, John N.] Washington Univ, Dept Psychiat, St Louis, MO USA.
   [Weisskopf, Marc G.; Ascherio, Alberto; Santangelo, Susan L.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Weisskopf, Marc G.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   [Roberts, Andrea L.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Ascherio, Alberto] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.
   [Ascherio, Alberto] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Santangelo, Susan L.] Maine Med Ctr, Res Inst, Dept Psychiat, Portland, ME USA.
RP Lyall, K (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 655 Huntington Ave,Bldg 2,Third Floor, Boston, MA 02115 USA.
EM klyall@hsph.harvard.edu
FU National Institutes of Health [CA50385, HD062171, HD042541]; Autism
   Speaks [1788, 2210]; US Army Medical Research and Material Command
   [A-14917]
FX This work was supported by grants CA50385, HD062171, and HD042541 from
   the National Institutes of Health, grants 1788 and 2210 from Autism
   Speaks, and grant A-14917 from the US Army Medical Research and Material
   Command.
CR Aldridge FJ, 2012, J AUTISM DEV DISORD, V42, P294, DOI 10.1007/s10803-011-1242-9
   Bolte S, 2012, J AUTISM DEV DISORD, V42, P1998, DOI 10.1007/s10803-011-1424-5
   Constantino J. N., 2012, SOCIAL RESPONSIVENES, Vsecond
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Constantino JN, 2009, DEV PSYCHOPATHOL, V21, P127, DOI 10.1017/S095457940900008X
   Constantino JN, 2013, J CHILD PSYCHOL PSYC, V54, P695, DOI 10.1111/jcpp.12064
   Constantino JN, 2012, J AM ACAD CHILD PSY, V51, P756, DOI 10.1016/j.jaac.2012.05.017
   Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
   Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
   De la Marche W, 2012, AUTISM, V16, P247, DOI 10.1177/1362361311421776
   Frazier TW, 2014, AUTISM, V18, P31, DOI 10.1177/1362361313500382
   Frazier TW, 2013, AUTISM, DOI [10.1177/136236113481506, DOI 10.1177/136236113481506]
   Gronborg TK, 2013, JAMA PEDIATR, V167, P947, DOI 10.1001/jamapediatrics.2013.2259
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Ho A, 2005, J AUTISM DEV DISORD, V35, P129, DOI 10.1007/s10803-004-1040-8
   Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
   Kamio Y, 2013, AUTISM, V17, P15, DOI 10.1177/1362361312436848
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lyall K, 2012, PAEDIATR PERINAT EP, V26, P361, DOI 10.1111/j.1365-3016.2012.01294.x
   Movsas TZ, 2012, J AUTISM DEV DISORD, V42, P2431, DOI 10.1007/s10803-012-1501-4
   Pearl AM, 2013, AUTISM, V17, P736, DOI 10.1177/1362361312453349
   Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
   Robinson EB, 2013, P NATL ACAD SCI USA, V110, P5258, DOI 10.1073/pnas.1211070110
   Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
   RUBIN DB, 1991, STAT MED, V10, P585, DOI 10.1002/sim.4780100410
   Schwichtenberg AJ, 2010, J CHILD PSYCHOL PSYC, V51, P1021, DOI 10.1111/j.1469-7610.2010.02267.x
   Solomon CG, 1997, JAMA-J AM MED ASSOC, V278, P1078, DOI 10.1001/jama.278.13.1078
   Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810
   Wang J, 2012, J AUTISM DEV DISORD, V42, P2450, DOI 10.1007/s10803-012-1499-7
   Ward-King J, 2010, J AUTISM DEV DISORD, V40, P1285, DOI 10.1007/s10803-010-0987-x
   Wigham S, 2012, RES DEV DISABIL, V33, P944
   Yang Y, 2013, MULTIPLE IMPUTATION
NR 36
TC 3
Z9 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD AUG
PY 2014
VL 71
IS 8
BP 936
EP 942
DI 10.1001/jamapsychiatry.2014.476
PG 7
WC Psychiatry
SC Psychiatry
GA AP0SP
UT WOS:000341774600012
PM 25100167
ER

PT J
AU Hoffmann, TJ
   Windham, GC
   Anderson, M
   Croen, LA
   Grether, JK
   Risch, N
AF Hoffmann, Thomas J.
   Windham, Gayle C.
   Anderson, Meredith
   Croen, Lisa A.
   Grether, Judith K.
   Risch, Neil
TI Evidence of Reproductive Stoppage in Families With Autism Spectrum
   Disorder A Large, Population-Based Cohort Study
SO JAMA PSYCHIATRY
LA English
DT Article
ID EPIDEMIOLOGIC SURVEY; RISK; RECURRENCE; TWIN; SIBLINGS
AB IMPORTANCE Few studies have examined the curtailment of reproduction (ie, stoppage) after the diagnosis of a child with autism spectrum disorder (ASD).
   OBJECTIVE To examine stoppage in a large, population-based cohort of families in which a child has received a diagnosis of ASD.
   DESIGN, SETTING, AND PARTICIPANTS Individuals with ASD born from January 1,1990, through December 31, 2003, were identified in the California Department of Developmental Services records, which were then linked to state birth certificates to identify full sibs and half-sibs and to obtain information on birth order and demographics. A total of 19 710 case families in which the first birth occurred within the study period was identified. These families included 39 361 individuals (sibs and half-sibs). Control individuals were randomly sampled from birth certificates and matched 2:1 to cases by sex, birth year, and maternal age, self-reported race/ethnicity, and county of birth after removal of children receiving services from the California Department of Developmental Services. Using similar linkage methods as for case families, 36 215 pure control families (including 75 724 total individuals) were identified that had no individuals with an ASD diagnosis.
   EXPOSURES History of affected children.
   MAIN OUTCOMES AND MEASURES Stoppage was investigated by comparing the reproductive behaviors of parents after the birth of a child with ASD vs an unaffected child using a survival analysis framework for time to next birth and adjusting for demographic variables.
   RESULTS For the first few years after the birth of a child with ASD, the parents' reproductive behavior was similar to that of control parents. However, birth rates differed in subsequent years; overall, families whose first child had ASD had a second child at a rate of 0.668 (95% CI, 0.635-0.701) that of control families, adjusted for birth year, birth weight, maternal age, and self-reported maternal race/ethnicity. Results were similar when a later-born child was the first affected child in the family. Reproductive curtailment was slightly stronger among women who changed partners (relative rate for second-born children, 0.553 [95% CI, 0.498-0.614]).
   CONCLUSIONS AND RELEVANCE These results provide the first quantitative assessment and convincing statistical evidence of reproductive stoppage related to ASD. These findings have implications for recurrence risk estimation and genetic counseling.
C1 [Hoffmann, Thomas J.; Risch, Neil] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA.
   [Hoffmann, Thomas J.; Risch, Neil] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Windham, Gayle C.; Anderson, Meredith; Grether, Judith K.] Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA USA.
   [Croen, Lisa A.; Risch, Neil] Kaiser Permanente, Div Res, Oakland, CA USA.
RP Risch, N (reprint author), Univ Calif San Francisco, Inst Human Genet, 513 Parnassus Ave, San Francisco, CA 94143 USA.
EM rischn@humgen.ucsf.edu
FU Institute for Human Genetics, University of California, San Francisco;
   National Cancer Institute [R25 CA112355]
FX This work was supported by funds from the Institute for Human Genetics,
   University of California, San Francisco, and by grant R25 CA112355 from
   the National Cancer Institute.
CR Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
   DAVIE AM, 1979, ANN HUM GENET, V42, P507, DOI 10.1111/j.1469-1809.1979.tb00683.x
   Folstein S, 1977, J CHILD PSYCHOL PSYC, V18, P297
   Freedman BH, 2012, J AUTISM DEV DISORD, V42, P539, DOI 10.1007/s10803-011-1269-y
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Grether JK, 2009, AM J EPIDEMIOL, V170, P1118, DOI 10.1093/aje/kwp247
   Gronborg TK, 2013, JAMA PEDIATR, V167, P947, DOI 10.1001/jamapediatrics.2013.2259
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   JONES MB, 1988, J AUTISM DEV DISORD, V18, P31, DOI 10.1007/BF02211816
   Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Risi S, 2006, J AM ACAD CHILD ADOL, V45, P1094
   RITVO ER, 1989, AM J PSYCHIAT, V146, P194
   RITVO ER, 1985, AM J PSYCHIAT, V142, P187
   Simonoff E, 1998, J AUTISM DEV DISORD, V28, P447, DOI 10.1023/A:1026060623511
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Sumi S, 2006, J HUM GENET, V51, P518, DOI 10.1007/s10038-006-0392-7
NR 20
TC 1
Z9 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD AUG
PY 2014
VL 71
IS 8
BP 943
EP 951
DI 10.1001/jamapsychiatry.2014.420
PG 9
WC Psychiatry
SC Psychiatry
GA AP0SP
UT WOS:000341774600013
PM 24942798
ER

PT J
AU Laprime, AP
   Dittrich, GA
AF Laprime, Amanda P.
   Dittrich, Gretchen A.
TI An Evaluation of a Treatment Package Consisting of Discrimination
   Training and Differential Reinforcement with Response Cost and a Social
   Story on Vocal Stereotypy for a Preschooler with Autism in a Preschool
   Classroom
SO EDUCATION AND TREATMENT OF CHILDREN
LA English
DT Article
DE Vocal Stereotypy; Response Cost; Differential Reinforcement;
   Changing-Criterion Design
ID AUTOMATIC REINFORCEMENT; BEHAVIOR DISORDERS; YOUNG-CHILDREN; DRL; INJURY
AB The purpose of the study was to evaluate the use of a treatment package comprised of a social story, discrimination training, and differential reinforcement with response cost on the vocal stereotypy of one preschooler diagnosed with an autism spectrum disorder. The study took place in a preschool classroom of a public school and was implemented by the classroom teacher and staff. A changing criterion design was employed to evaluate experimental control. The results of this study demonstrated a clear decrease in vocal stereotypy as compared to baseline.
C1 [Laprime, Amanda P.; Dittrich, Gretchen A.] Simmons Coll, Boston, MA 02115 USA.
RP Laprime, AP (reprint author), Simmons Coll, Dept Behav Anal, 300 Fenway, Boston, MA 02115 USA.
EM aplaprime@gmail.com
CR Ahearn WH, 2007, J APPL BEHAV ANAL, V40, P263, DOI 10.1901/jaba.2007.30-06
   Alderman N, 1997, BRAIN INJURY, V11, P79, DOI 10.1080/026990597123683
   Ali S., 2006, ED PSYCHOL PRACTICE, V22, P355, DOI DOI 10.1080/02667360600999500
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Austin JL, 2011, J APPL BEHAV ANAL, V44, P451, DOI 10.1901/jaba.2011.44-451
   Bijou S. W, 1963, ADV CHILD DEV BEHAV, P197
   Buckley SD, 2005, J APPL BEHAV ANAL, V38, P405, DOI 10.1901/jaba.2005.71-04
   Catania C. A., 1997, LEARNING
   CHARLOP MH, 1990, J APPL BEHAV ANAL, V23, P163, DOI 10.1901/jaba.1990.23-163
   Cooper J. O., 2007, APPL BEHAV ANAL
   DEITZ SM, 1977, BEHAV RES THER, V15, P103, DOI 10.1016/0005-7967(77)90093-6
   Falcomata TS, 2004, J APPL BEHAV ANAL, V37, P83, DOI 10.1901/jaba.2004.37-83
   Fester C. B., 1957, SCHEDULES REINFORCEM
   Grate C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1
   Hall R. V., 1971, MANAGING BEHAV MODIF, P54
   IWATA BA, 1982, ANAL INTERVEN DEVEL, V2, P3, DOI 10.1016/0270-4684(82)90003-9
   Johnston J., 1980, STRATEGIES TACTICS H
   Kazdin A. E., 1982, SINGLE CASE RES DESI
   Kokina A, 2010, J AUTISM DEV DISORD, V40, P812, DOI 10.1007/s10803-009-0931-0
   Kostinas G, 2001, BEHAV INTERVENT, V16, P27, DOI 10.1002/bin.70
   Kuttler S., 1998, FOCUS AUTISM OTHER D, V13, P176, DOI DOI 10.1177/108835769801300306
   Laraway S, 2003, J APPL BEHAV ANAL, V36, P407, DOI 10.1901/jaba.2003.36-407
   Lerman DC, 2002, J APPL BEHAV ANAL, V35, P431, DOI 10.1901/jaba.2002.35-431
   Lloyd D. M., 2007, PEABODY PICTURE VOCA
   Martin G, 2010, BEHAV MODIFICATION W
   Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
   Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
   Rapp JT, 2009, BEHAV INTERVENT, V24, P85, DOI 10.1002/bin.276
   Reimers T. M., 1988, BEHAVIORAL DISORDERS, V14, P7
   RINCOVER A, 1978, J ABNORM CHILD PSYCH, V6, P299, DOI 10.1007/BF00924733
   Rogers S. J., 1981, DEV PROGRAMMING INFA, V2
   Rust J, 2006, AUTISM, V10, P125, DOI 10.1177/1362361306062019
   Semel E., 2003, CLIN EVALUATION LANG, V4th
   SINGH NN, 1981, J APPL BEHAV ANAL, V14, P521, DOI 10.1901/jaba.1981.14-521
   Skinner B. F., 1957, VERBAL BEHAV
   Smith C., 2001, ED PSYCHOL PRACTICE, V17, P337, DOI 10.1080/02667360127230
   Truchlicka M., 1998, BEHAV INTERVENT, V13, P1, DOI 10.1002/(SICI)1099-078X(199802)13:1<1::AID-BIN1>3.0.CO;2-Z
   VAUGHAN ME, 1982, BEHAVIORISM, V10, P217
NR 38
TC 0
Z9 0
PU WEST VIRGINIA UNIV PRESS
PI MORGANTOWN
PA COMMUNICATIONS BLDG PATTESON DR, PO BOX 6295, MORGANTOWN, WV 26506-6295
   USA
SN 0748-8491
EI 1934-8924
J9 EDUC TREAT CHILD
JI Educ. Treat. Child.
PD AUG
PY 2014
VL 37
IS 3
BP 407
EP 430
PG 24
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AP4GL
UT WOS:000342035100003
ER

PT J
AU Ruan, CS
   Wang, SF
   Shen, YJ
   Guo, Y
   Yang, CR
   Zhou, FH
   Tan, LT
   Zhou, L
   Liu, JJ
   Wang, WY
   Xiao, ZC
   Zhou, XF
AF Ruan, Chun-Sheng
   Wang, Shu-Fen
   Shen, Yan-Jun
   Guo, Yi
   Yang, Chun-Rui
   Zhou, Fiona H.
   Tan, Li-Tao
   Zhou, Li
   Liu, Jian-Jun
   Wang, Wen-Yue
   Xiao, Zhi-Cheng
   Zhou, Xin-Fu
TI Deletion of TRIM32 protects mice from anxiety- and depression-like
   behaviors under mild stress
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE affective behavior; CUMS; fluoxetine; locomotor activity; TRIM32
ID ADULT HIPPOCAMPAL NEUROGENESIS; ELEVATED ZERO-MAZE; DYSTROPHY TYPE 2H;
   SOCIAL-ISOLATION; MOUSE MODEL; RAT MODEL; APOPTOSIS; CELLS; DOPAMINE;
   DIFFERENTIATION
AB Chronic stress causes a variety of psychiatric disorders such as anxiety and depression, but its mechanism is not well understood. Tripartite motif-containing protein 32 (TRIM32) was strongly associated with autism spectrum disorder, attention deficit hyperactivity disorder, anxiety and obsessive compulsive disorder based on a study of copy number variation, and deletion of TRIM32 increased neural proliferation and reduced apoptosis. Here, we propose that TRIM32 is involved in chronic stress-induced affective behaviors. Using a chronic unpredictable mild stress mouse depression model, we studied expression of TRIM32 in brain tissue samples and observed behavioral changes in Trim32 knockout mice. The results showed that TRIM32 protein but not its mRNA was significantly reduced in hippocampus in a time-dependent manner within 8 weeks of chronic stress. These stress-induced affective behaviors and reduction of TRIM32 protein expression were significantly reversed by antidepressant fluoxetine treatment. In addition, Trim32 knockout mice showed reduced anxiety and depressive behaviors and hyperactivities compared with Trim32 wild-type mice under normal and mild stress conditions. We conclude that TRIM32 plays important roles in regulation of hyperactivities and positively regulates the development of anxiety and depression disorders induced by chronic stress.
C1 [Ruan, Chun-Sheng; Wang, Shu-Fen; Shen, Yan-Jun; Guo, Yi; Yang, Chun-Rui; Tan, Li-Tao; Zhou, Li; Liu, Jian-Jun; Wang, Wen-Yue; Xiao, Zhi-Cheng; Zhou, Xin-Fu] Kunming Med Univ, Inst Mol & Clin Med, Key Lab Stem Cell & Regenerat Med, Kunming, Peoples R China.
   [Ruan, Chun-Sheng; Zhou, Fiona H.; Zhou, Xin-Fu] Univ S Australia, Sch Pharm & Med Sci, Div Hlth Sci, Adelaide, SA 5000, Australia.
   [Shen, Yan-Jun; Guo, Yi; Yang, Chun-Rui] Kunming Med Univ, Sch Med Sci, Kunming, Peoples R China.
   [Xiao, Zhi-Cheng] Monash Univ, Dept Anat & Dev Biol, Clayton, Vic, Australia.
RP Ruan, CS (reprint author), Univ S Australia, Sch Pharm & Med Sci, Div Hlth Sci, Adelaide, SA 5000, Australia.
EM ruacy004@mymail.unisa.edu.au
FU Chinese MST [2011CB944200]; NHMRC [APP1021408, APP1021409]; Talent
   Program of Yunnan Province, China; Monash University, Australia;
   KMU-UIEP [CX201111, CX201244, CX201241]
FX We thank Dr H. Ding for kindly providing TRIM32 knockout mice and Dr J.
   C. Schwamborn for kindly providing antibody against TRIM32. We thank Dr
   B. T. Baune for valuable comments. This work was supported by grants
   from the Chinese MST 2011CB944200 and NHMRC grants (APP1021408 and
   APP1021409), the Talent Program of Yunnan Province, China, and The
   Professorial Fellowship of Monash University, Australia, to Z.C.X., and
   KMU-UIEP grants (CX201111, CX201244 and CX201241) to C. S. R. X.F.Z. is
   a visiting Professor of KMU.
CR Anacker C., 2014, CURR TOP BEHAV NEURO, DOI [10.1007/7854_2014_275, DOI 10.1007/7854_2014_275]
   Bell R, 2014, SCI REP-UK, V4, DOI 10.1038/srep03881
   Berlin I, 1998, EUR PSYCHIAT, V13, P303, DOI 10.1016/S0924-9338(98)80048-5
   Brenes JC, 2008, NEUROSCI LETT, V436, P278, DOI 10.1016/j.neulet.2008.03.045
   Castagne V., 2010, CURR PROTOC PHARM, V5, P58
   Castagne V, 2011, CURR PROTOC NEUROSCI, V8
   Danzer SC, 2012, EXP NEUROL, V233, P22, DOI 10.1016/j.expneurol.2011.05.023
   Djordjevic A, 2012, PROG NEURO-PSYCHOPH, V36, P92, DOI 10.1016/j.pnpbp.2011.10.006
   Evans J, 2012, NEUROPHARMACOLOGY, V63, P1315, DOI 10.1016/j.neuropharm.2012.08.012
   Fava M, 2012, J PSYCHIATR RES, V46, P1553, DOI 10.1016/j.jpsychires.2012.08.013
   Forsythe E., 1993, GENEREVIEWS, P1993
   Frosk P, 2005, HUM MUTAT, V25, P38, DOI 10.1002/humu.20110
   Frosk P, 2002, AM J HUM GENET, V70, P663, DOI 10.1086/339083
   GOTO SH, 1993, BRAZ J MED BIOL RES, V26, P965
   Guan SZ, 2014, ENVIRON TOXICOL PHAR, V37, P414, DOI 10.1016/j.etap.2013.12.013
   Hillje AL, 2011, STEM CELLS, V29, P1437, DOI 10.1002/stem.687
   Hillje AL, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.487
   Horn EJ, 2004, CARCINOGENESIS, V25, P157, DOI 10.1093/carcin/bgh003
   Hu D., 2013, BRAIN BEHAV IMMUN, V36, P118
   Kano S, 2008, CANCER RES, V68, P5572, DOI 10.1158/0008-5472.CAN-07-6231
   Karson A, 2013, BASIC CLIN PHARMACOL, V112, P335, DOI 10.1111/bcpt.12037
   Kasper S, 2008, CNS DRUGS, V22, P15
   Kim JI, 2013, BRAIN RES, V1538, P26, DOI 10.1016/j.brainres.2013.09.007
   Kudryashova E, 2005, J MOL BIOL, V354, P413, DOI 10.1016/j.jmb.2005.09.068
   Kudryashova E, 2012, J CLIN INVEST, V122, P1764, DOI 10.1172/JCI59581
   Kumar B, 2011, PSYCHOPHARMACOLOGY, V214, P819, DOI 10.1007/s00213-010-2094-2
   Lee HJ, 2001, MOL PSYCHIATR, V6, P725, DOI 10.1038/sj.mp.4000947
   Lionel AC, 2014, HUM MOL GENET, V23, P2752, DOI 10.1093/hmg/ddt669
   Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
   Liu YD, 2010, PHARM BIOL, V48, P840, DOI 10.3109/13880200903296154
   Napolitano LM, 2011, BIOCHEM J, V434, P309, DOI 10.1042/BJ20101487
   NISHIMURA H, 1988, PHYSIOL BEHAV, V42, P93, DOI 10.1016/0031-9384(88)90266-1
   Nollet M., 2013, CURR PROTOC PHARM, V5, P565
   Ohira K, 2013, NEUROPSYCHOPHARMACOL, V38, P909, DOI 10.1038/npp.2013.2
   Pan YQ, 2013, BEHAV BRAIN RES, V247, P232, DOI 10.1016/j.bbr.2013.03.031
   Parihar VK, 2011, MOL PSYCHIATR, V16, P171, DOI 10.1038/mp.2009.130
   Pruett BS, 2013, MOL NEUROBIOL, V47, P988, DOI 10.1007/s12035-013-8397-7
   Rahmani A, 2013, BIOMED RES INT, DOI 10.1155/2013/582526
   Rygula R, 2005, BEHAV BRAIN RES, V162, P127, DOI 10.1016/j.bbr.2005.03.009
   Ryu YS, 2011, J BIOL CHEM, V286, P25729, DOI 10.1074/jbc.M111.241893
   Sato T, 2011, J CELL SCI, V124, P3492, DOI 10.1242/jcs.088799
   Schwamborn JC, 2009, CELL, V136, P913, DOI 10.1016/j.cell.2008.12.024
   SHEPHERD JK, 1994, PSYCHOPHARMACOLOGY, V116, P56, DOI 10.1007/BF02244871
   Sikstrom S, 2007, PSYCHOL REV, V114, P1047, DOI 10.1037/0033-295X.114.4.1047
   Slattery DA, 2012, PSYCHONEUROENDOCRINO, V37, P702, DOI 10.1016/j.psyneuen.2011.09.002
   Snyder JS, 2011, NATURE, V476, P458, DOI 10.1038/nature10287
   Song C, 2011, PROG NEURO-PSYCHOPH, V35, P760, DOI 10.1016/j.pnpbp.2010.06.020
   Sudakov SK, 2013, B EXP BIOL MED+, V155, P295, DOI 10.1007/s10517-013-2136-y
   Xinxing W, 2014, PLOS ONE, V9
   Yanamoto H, 2005, STROKE, V36, P1544, DOI 10.1161/01.STR.0000169903.09253.c7
   Yang CR, 2014, NEUROTOX RES, V25, P235, DOI 10.1007/s12640-013-9411-6
   Yao SQ, 2007, INT J NEUROSCI, V117, P1551, DOI 10.1080/00207450701239285
   Yokota T, 2006, EUR J CLIN INVEST, V36, P820, DOI 10.1111/j.1365-2362.2006.01722.x
   Yoo SB, 2013, PSYCHONEUROENDOCRINO, V38, P777, DOI 10.1016/j.psyneuen.2012.08.013
   Zhang S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051148
NR 55
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD AUG
PY 2014
VL 40
IS 4
BP 2680
EP 2690
DI 10.1111/ejn.12618
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AP3NF
UT WOS:000341982100009
PM 24839933
ER

PT J
AU Hebert, B
   Pietropaolo, S
   Meme, S
   Laudier, B
   Laugeray, A
   Doisne, N
   Quartier, A
   Lefeuvre, S
   Got, L
   Cahard, D
   Laumonnier, F
   Crusio, WE
   Pichon, J
   Menuet, A
   Perche, O
   Briault, S
AF Hebert, Betty
   Pietropaolo, Susanna
   Meme, Sandra
   Laudier, Beatrice
   Laugeray, Anthony
   Doisne, Nicolas
   Quartier, Angelique
   Lefeuvre, Sandrine
   Got, Laurence
   Cahard, Dominique
   Laumonnier, Frederic
   Crusio, Wim E.
   Pichon, Jacques
   Menuet, Arnaud
   Perche, Olivier
   Briault, Sylvain
TI Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa
   channel opener molecule
SO ORPHANET JOURNAL OF RARE DISEASES
LA English
DT Article
DE Fragile X Syndrome; BMS-204352; BKCa channel; Sociability; Cognition;
   Anxiety
ID ELEVATED PLUS-MAZE; MENTAL-RETARDATION SYNDROME; SYNDROME MOUSE MODEL;
   2-TRIAL MEMORY TASK; KNOCKOUT MICE; POTASSIUM CHANNELS; BEHAVIOR;
   AUTISM; MORPHOLOGY; ANXIETY
AB Background: Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and is also associated with autism spectrum disorders. Previous studies implicated BKCa channels in the neuropathogenesis of FXS, but the main question was whether pharmacological BKCa stimulation would be able to rescue FXS neurobehavioral phenotypes.
   Methods and results: We used a selective BKCa channel opener molecule (BMS-204352) to address this issue in Fmr1 KO mice, modeling the FXS pathophysiology. In vitro, acute BMS-204352 treatment (10 mu M) restored the abnormal dendritic spine phenotype. In vivo, a single injection of BMS-204352 (2 mg/kg) rescued the hippocampal glutamate homeostasis and the behavioral phenotype. Indeed, disturbances in social recognition and interaction, non-social anxiety, and spatial memory were corrected by BMS-204352 in Fmr1 KO mice.
   Conclusion: These results demonstrate that the BKCa channel is a new therapeutic target for FXS. We show that BMS-204352 rescues a broad spectrum of behavioral impairments (social, emotional and cognitive) in an animal model of FXS. This pharmacological molecule might open new ways for FXS therapy.
C1 [Hebert, Betty; Laudier, Beatrice; Laugeray, Anthony; Doisne, Nicolas; Quartier, Angelique; Pichon, Jacques; Menuet, Arnaud; Perche, Olivier; Briault, Sylvain] CNRS, UMR7355, F-45071 Orleans, France.
   [Hebert, Betty; Laudier, Beatrice; Laugeray, Anthony; Doisne, Nicolas; Quartier, Angelique; Pichon, Jacques; Menuet, Arnaud; Perche, Olivier; Briault, Sylvain] Univ Orleans, F-45071 Orleans 2, France.
   [Pietropaolo, Susanna; Crusio, Wim E.] CNRS, Aquitaine Inst Cognit & Integrat Neurosci, UMR 5287, Talence, France.
   [Pietropaolo, Susanna; Crusio, Wim E.] Univ Bordeaux, Aquitaine Inst Cognit & Integrat Neurosci, F-33405 Talence, France.
   [Meme, Sandra] Univ Orleans, CNRS, Ctr Biophys Mol, UPR4301, F-45071 Orleans, France.
   [Laudier, Beatrice; Lefeuvre, Sandrine; Got, Laurence; Perche, Olivier; Briault, Sylvain] Reg Hosp, Dept Genet, F-45100 Orleans, France.
   [Cahard, Dominique] INSA Rouen, UMR CNRS CBRA 6014, F-76821 Mont St Aignan, France.
   [Laumonnier, Frederic] INSERM, U930, F-37032 Tours, France.
   [Laumonnier, Frederic] Univ Tours, UMR Imagerie & Cerveau, F-37000 Tours, France.
RP Briault, S (reprint author), CNRS, UMR7355, F-45071 Orleans, France.
EM sbriault@cnrs-orleans.fr
RI Crusio, Wim/A-7070-2008
OI Crusio, Wim/0000-0001-6638-202X
FU Fondation de France [015448]; FRAXA Research Foundation (USA); FEDER
   Autism [35106]; Fondation Lejeune; CNRS (Soutien au transfert)
   [04388-02]; Region Centre; Regional Hospital of Orleans; University of
   Orleans; Project FP7 GENCODYS [241995]; March of Dimes [12-FY05-1198];
   Conseil Regional d'Aquitaine; CNRS; University of Bordeaux 1
FX We would like to thank Melanie Marcos for her excellent technical
   support and Alexandre Herpin, Jerome Larrigaldie and Ludovic Mercier for
   animal breeding. We also thank Jean-Claude Beloeil and Valerie Quesniaux
   for their continued support of the project. Research was supported in
   part by grants from Fondation de France 015448, The FRAXA Research
   Foundation (USA), FEDER Autism 35106, Fondation Lejeune, CNRS (Soutien
   au transfert 04388-02), Region Centre, Regional Hospital of Orleans, the
   University of Orleans and Project FP7 GENCODYS (no241995, to FL). W.C.
   and S.P. were supported by grants from the March of Dimes
   (12-FY05-1198), Conseil Regional d'Aquitaine, CNRS, and the University
   of Bordeaux 1 to W.C.
CR Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Boda B, 2014, EUR J NEUROSCI, V39, P1130, DOI 10.1111/ejn.12488
   BRAND A, 1993, DEV NEUROSCI-BASEL, V15, P289, DOI 10.1159/000111347
   Briault S, 2013, City, Patent No. [2/013/001/412, 2013001412]
   Cardenas F, 2001, BEHAV BRAIN RES, V122, P169, DOI 10.1016/S0166-4328(01)00180-2
   BAKKER CE, 1994, CELL, V78, P23
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   Davidovic L, 2011, GENOME RES, V21, P2190, DOI 10.1101/gr.116764.110
   DELLU F, 1992, BRAIN RES, V588, P132, DOI 10.1016/0006-8993(92)91352-F
   Dellu F, 2000, NEUROBIOL LEARN MEM, V73, P31, DOI 10.1006/nlme.1999.3919
   Dellu F, 1997, NEUROBIOL LEARN MEM, V67, P112, DOI 10.1006/nlme.1997.3746
   Deng PY, 2013, NEURON, V77, P696, DOI 10.1016/j.neuron.2012.12.018
   de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002
   Estanislau C, 2006, INT J DEV NEUROSCI, V24, P255, DOI 10.1016/j.ijdevneu.2006.03.001
   Ethell IM, 2001, NEURON, V31, P1001, DOI 10.1016/S0896-6273(01)00440-8
   Galvez R, 2005, AM J MED GENET A, V135A, P155, DOI 10.1002/ajmg.a.30709
   Garcia AMB, 2005, PHYSIOL BEHAV, V85, P440, DOI 10.1016/j.physbeh.2005.04.027
   Gribkoff VK, 2001, NEUROSCIENTIST, V7, P166
   Gribkoff VK, 2001, NAT MED, V7, P471, DOI 10.1038/86546
   Gross C, 2012, NEUROPSYCHOPHARMACOL, V37, P178, DOI 10.1038/npp.2011.137
   Grossman AW, 2010, BRAIN RES, V1355, P221, DOI 10.1016/j.brainres.2010.07.090
   Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
   Higashimori H, 2013, HUM MOL GENET, V22, P2041, DOI 10.1093/hmg/ddt055
   Higgins JJ, 2008, NEUROGENETICS, V9, P219, DOI 10.1007/s10048-008-0128-2
   Irwin SA, 2000, CEREB CORTEX, V10, P1038, DOI 10.1093/cercor/10.10.1038
   Jacobs S, 2010, J NEUROSCI, V30, P4508, DOI 10.1523/JNEUROSCI.5027-09.2010
   Jensen BS, 2002, CNS DRUG REV, V8, P353
   Latorre R, 2006, BIOL RES, V39, P385, DOI 10.4067/S0716-97602006000300003
   Laumonnier F, 2006, AM J PSYCHIAT, V163, P1622, DOI 10.1176/appi.ajp.163.9.1622
   Lee HY, 2012, CURR OPIN NEUROBIOL, V22, P887, DOI 10.1016/j.conb.2012.03.010
   Liao LJ, 2008, P NATL ACAD SCI USA, V105, P15281, DOI 10.1073/pnas.0804678105
   Liebau S, 2007, J NEUROCHEM, V101, P1338, DOI 10.1111/j.1471-4159.2006.04437.x
   Liu ZH, 2009, NEUROSCI LETT, V454, P62, DOI 10.1016/j.neulet.2009.02.066
   Martinez RCR, 2007, BEHAV BRAIN RES, V182, P135, DOI 10.1016/j.bbr.2007.04.015
   McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293]
   Meme S, 2009, TOXICOL SCI, V111, P321, DOI 10.1093/toxsci/kfp174
   MILLER BL, 1993, RADIOLOGY, V187, P433
   Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706
   Mineur YS, 2002, HIPPOCAMPUS, V12, P39, DOI 10.1002/hipo.10005
   Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x
   Nardi A, 2008, CURR MED CHEM, V15, P1126, DOI 10.2174/092986708784221412
   Pacey LKK, 2011, J PHARMACOL EXP THER, V338, P897, DOI 10.1124/jpet.111.183327
   Pietropaolo Susanna, 2011, PLoS One, V6, pe17073, DOI 10.1371/journal.pone.0017073
   Qin M, 2011, NEUROSCIENCE, V194, P282, DOI 10.1016/j.neuroscience.2011.06.047
   Salkoff L, 2006, NAT REV NEUROSCI, V7, P921, DOI 10.1038/nrn1992
   Shi D, 2012, J NEUROCHEM, V123, P971, DOI 10.1111/jnc.12048
   Sun MK, 2014, J PHARMACOL EXP THER, V349, P393, DOI 10.1124/jpet.114.214098
   Thomas CC, 2008, INT J DEV NEUROSCI, V26, P805, DOI 10.1016/j.ijdevneu.2008.06.003
   Typlt M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081270
   Wei HE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036981
   Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
   Yang Q, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1003172
   Yuskaitis CJ, 2010, BBA-MOL BASIS DIS, V1802, P1006, DOI 10.1016/j.bbadis.2010.06.015
   Yuskaitis CJ, 2010, BIOCHEM PHARMACOL, V79, P632, DOI 10.1016/j.bcp.2009.09.023
   Zhou X, 2011, EXP NEUROL, V229, P471, DOI 10.1016/j.expneurol.2011.03.018
NR 56
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1750-1172
J9 ORPHANET J RARE DIS
JI Orphanet J. Rare Dis.
PD AUG 1
PY 2014
VL 9
AR 124
DI 10.1186/s13023-014-0124-6
PG 10
WC Genetics & Heredity; Medicine, Research & Experimental
SC Genetics & Heredity; Research & Experimental Medicine
GA AP0FC
UT WOS:000341735700001
PM 25079250
ER

PT J
AU Lancioni, GE
   Singh, NN
   O'Reilly, MF
   Sigafoos, J
   Boccasini, A
   La Martire, ML
   Lang, R
AF Lancioni, Giulio E.
   Singh, Nirbhay N.
   O'Reilly, Mark F.
   Sigafoos, Jeff
   Boccasini, Adele
   La Martire, Maria L.
   Lang, Russell
TI CASE STUDIES OF TECHNOLOGY FOR ADULTS WITH MULTIPLE DISABILITIES TO MAKE
   TELEPHONE CALLS INDEPENDENTLY
SO PERCEPTUAL AND MOTOR SKILLS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; INTELLECTUAL DISABILITY; ASSISTIVE
   TECHNOLOGY; SOCIAL VALIDATION; BRAIN-INJURY; YOUNG-ADULTS;
   COMMUNICATION; INDIVIDUALS; COMPUTER; SYSTEM
AB Recent literature has shown the possibility of enabling individuals with multiple disabilities to make telephone calls independently via computer-aided telephone technology. These two case studies assessed a modified version of such technology and a commercial alternative to it for a woman and a man with multiple disabilities, respectively. The modified version used in Study 1 (a) presented the names of the persons available for a call and (b) reminded the participant of the response she needed to perform (i.e., pressing a microswitch) if she wanted to call any of those names/persons. The commercial device used in Study 2 was a Galaxy S3 (Samsung) equipped with the S-voice module, which allowed the participant to activate phone calls by uttering the word "Call" followed by the name of the persons he wanted to call. The results of the studies showed that the participants learned to make phone calls independently using the technology/device available. Implications of the results are discussed.
C1 [Lancioni, Giulio E.] Univ Bari, I-70100 Bari, Italy.
   [Singh, Nirbhay N.] Georgia Regents Univ, Med Coll Georgia, Augusta, GA USA.
   [O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
   [Sigafoos, Jeff] Victoria Univ Wellington, Wellington, New Zealand.
   [Boccasini, Adele; La Martire, Maria L.] Lega F DOro Res Ctr, Osimo, Italy.
   [Boccasini, Adele; La Martire, Maria L.] Lega F DOro Res Ctr, Molfetta, Italy.
   [Lang, Russell] Texas State Univ San Marcos, San Marcos, TX USA.
RP Lancioni, GE (reprint author), Univ Bari, Dept Neurosci & Sense Organs, Via Quintino Sella 268, I-70100 Bari, Italy.
EM giulio.lancioni@uniba.it
CR Ayres KM, 2013, PSYCHOL SCHOOLS, V50, P259, DOI 10.1002/pits.21673
   Barlow D., 2009, SINGLE CASE EXPT DES
   Borg J, 2011, DISABIL SOC, V26, P151, DOI 10.1080/09687599.2011.543862
   Braun KVN, 2009, RES DEV DISABIL, V30, P179, DOI 10.1016/j.ridd.2008.02.004
   Burgstahler S, 2011, NEUROREHABILITATION, V28, P183, DOI 10.3233/NRE-2011-0648
   Callahan K, 2008, J AUTISM DEV DISORD, V38, P678, DOI 10.1007/s10803-007-0434-9
   Dahlin E., 2011, ASSIST TECHNOL, V29, P294, DOI DOI 10.3233/978-1-60750-814-4-294
   de Joode EA, 2012, BRAIN INJURY, V26, P1257, DOI 10.3109/02699052.2012.667590
   DePompei R, 2008, NEUROREHABILITATION, V23, P487
   Foley A, 2012, J RES SPECIAL ED NEE, V12, P192, DOI DOI 10.1111/J.1471-3802.2011.01230.X
   Hoppestad Brian Scott, 2013, Disabil Rehabil Assist Technol, V8, P190, DOI 10.3109/17483107.2012.723239
   Hua YJ, 2013, FOCUS AUTISM DEV DIS, V28, P89, DOI 10.1177/1088357613477473
   Hutchins TL, 2014, CHILD ADOL PSYCH CL, V23, P41, DOI 10.1016/j.chc.2013.07.003
   KAZDIN AE, 2001, BEHAV MODIFICATION A
   Kennedy C, 2005, SINGLE CASE DESIGNS
   Kim J, 2010, IEEE ENG MED BIO, P5250
   Koyama T, 2011, RES DEV DISABIL, V32, P2235, DOI 10.1016/j.ridd.2011.05.003
   Lancioni GE, 2014, AUT CHILD PSYCHO, P1, DOI 10.1007/978-1-4899-8029-8
   Lancioni GE, 2011, DEV NEUROREHABIL, V14, P283, DOI 10.3109/17518423.2011.586372
   Lancioni GE, 2013, RES DEV DISABIL, V34, P4178, DOI 10.1016/j.ridd.2013.08.042
   Lancioni GE, 2011, RES DEV DISABIL, V32, P2739, DOI 10.1016/j.ridd.2011.05.036
   Lancioni GE, 2011, RES DEV DISABIL, V32, P2330, DOI 10.1016/j.ridd.2011.07.033
   Lancioni GE, 2010, BRAIN INJURY, V24, P1236, DOI 10.3109/02699052.2010.506857
   Lancioni GE, 2013, RES DEV DISABIL, V34, P2959, DOI 10.1016/j.ridd.2013.06.006
   Lancioni GE, 2012, DEV NEUROREHABIL, V15, P31, DOI 10.3109/17518423.2011.631594
   Luiselli JK, 2010, BEHAV MODIF, V34, P403, DOI 10.1177/0145445510383526
   Mechling LC, 2011, EDUC TRAIN AUTISM DE, V46, P479
   Naslund R, 2013, DISABIL SOC, V28, P28, DOI 10.1080/09687599.2012.695528
   Nguyen T, 2007, ASSIST TECHNOL, V19, P78
   NGUYEN T., 2008, TECHNOLOGY DISABILIT, V20, P225
   Perilli V, 2013, RES DEV DISABIL, V34, P1991, DOI 10.1016/j.ridd.2013.03.016
   Ripat Jacquie, 2011, Disabil Rehabil Assist Technol, V6, P87, DOI 10.3109/17483107.2010.507859
   Luckasson Ruth, 2012, Journal of Special Education Technology, V27
   Scherer MJ, 2011, DISABIL REHABIL, V33, P811, DOI 10.3109/09638288.2010.511418
   Shih CH, 2013, RES DEV DISABIL, V34, P1521, DOI 10.1016/j.ridd.2013.01.018
   Shih Ching-Tien, 2011, Disabil Rehabil Assist Technol, V6, P169, DOI 10.3109/17483107.2010.522679
   Solish A, 2010, J APPL RES INTELLECT, V23, P226, DOI 10.1111/j.1468-3148.2009.00525.x
   Stock SE, 2008, J INTELL DISABIL RES, V52, P1155, DOI 10.1111/j.1365-2788.2008.01099.x
   Tomasik M, 2007, J VISUAL IMPAIR BLIN, V101, P657
   Travis RW, 2013, J APPL RES INTELLECT, V26, P481, DOI 10.1111/jar.12033
   Tullis CA, 2011, EDUC TRAIN AUTISM DE, V46, P576
   Wallace J, 2011, NEUROREHABILITATION, V28, P295, DOI 10.3233/NRE-2011-0657
   Wehmeyer ML, 2013, J SPEC EDUC, V46, P195, DOI 10.1177/0022466910392377
   Winkler SLH, 2010, MED CARE, V48, P558, DOI 10.1097/MLR.0b013e3181bd4a11
NR 44
TC 0
Z9 0
PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0031-5125
J9 PERCEPT MOTOR SKILL
JI Percept. Mot. Skills
PD AUG
PY 2014
VL 119
IS 1
BP 320
EP 331
DI 10.2466/15.PMS.119c14z4
PG 12
WC Psychology, Experimental
SC Psychology
GA AO7GV
UT WOS:000341521400028
PM 25153758
ER

PT J
AU Honti, F
   Meader, S
   Webber, C
AF Honti, Frantisek
   Meader, Stephen
   Webber, Caleb
TI Unbiased Functional Clustering of Gene Variants with a
   Phenotypic-Linkage Network
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID DE-NOVO MUTATIONS; SEMANTIC SIMILARITY; INTELLECTUAL DISABILITY;
   COMPREHENSIVE RESOURCE; EXPRESSION PATTERNS; DISEASE GENES; DATABASE;
   AUTISM; MOUSE; ONTOLOGY
AB Groupwise functional analysis of gene variants is becoming standard in next-generation sequencing studies. As the function of many genes is unknown and their classification to pathways is scant, functional associations between genes are often inferred from large-scale omics data. Such data types-including protein-protein interactions and gene co-expression networks-are used to examine the interrelations of the implicated genes. Statistical significance is assessed by comparing the interconnectedness of the mutated genes with that of random gene sets. However, interconnectedness can be affected by confounding bias, potentially resulting in false positive findings. We show that genes implicated through de novo sequence variants are biased in their coding-sequence length and longer genes tend to cluster together, which leads to exaggerated p-values in functional studies; we present here an integrative method that addresses these bias. To discern molecular pathways relevant to complex disease, we have inferred functional associations between human genes from diverse data types and assessed them with a novel phenotype-based method. Examining the functional association between de novo gene variants, we control for the heretofore unexplored confounding bias in coding-sequence length. We test different data types and networks and find that the disease-associated genes cluster more significantly in an integrated phenotypic-linkage network than in other gene networks. We present a tool of superior power to identify functional associations among genes mutated in the same disease even after accounting for significant sequencing study bias and demonstrate the suitability of this method to functionally cluster variant genes underlying polygenic disorders.
C1 [Honti, Frantisek; Meader, Stephen; Webber, Caleb] Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford, England.
RP Honti, F (reprint author), Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford, England.
EM caleb.webber@dpag.ox.ac.uk
FU Medical Research Council, UK under the EU [241995]
FX This work was funded by the Medical Research Council, UK, under the EU
   7th Framework Programme, project GENCODYS (grant no. 241995). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Alizadeh AA, 2000, NATURE, V403, P503, DOI 10.1038/35000501
   Allen AS, 2013, NATURE, V501, P217, DOI 10.1038/nature12439
   Ashburner M, 2000, NAT GENET, V25, P25
   Brown SDM, 2012, MAMM GENOME, V23, P632, DOI 10.1007/s00335-012-9427-x
   Brunner HG, 2004, NAT REV GENET, V5, P545, DOI 10.1038/nrg1383
   Couto FM, 2007, DATA KNOWL ENG, V61, P137, DOI 10.1016/j.datak.2006.05.003
   Croft D, 2011, NUCLEIC ACIDS RES, V39, pD691, DOI 10.1093/nar/gkq1018
   de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
   Dietmann S, 2009, BIOINFORMATICS, V25, P830, DOI 10.1093/bioinformatics/btp055
   Eppig JT, 2012, NUCLEIC ACIDS RES, V40, pD881, DOI 10.1093/nar/gkr974
   Franke L, 2006, AM J HUM GENET, V78, P1011, DOI 10.1086/504300
   Gillis J, PLOS ONE, V6
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
   Hunter S, 2012, NUCLEIC ACIDS RES, V40, pD306, DOI 10.1093/nar/gkr948
   Jimenez-Sanchez G, 2001, NATURE, V409, P853, DOI 10.1038/35057050
   Kampmann B, 2005, J CLIN INVEST, V115, P2480, DOI 10.1172/JCI19316
   Kanehisa M, 2010, NUCLEIC ACIDS RES, V38, pD355, DOI 10.1093/nar/gkp896
   Kerrien S, 2012, NUCLEIC ACIDS RES, V40, pD841, DOI 10.1093/nar/gkr1088
   Lee I, 2004, SCIENCE, V306, P1555, DOI 10.1126/science.1099511
   Lee I, 2011, GENOME RES, V21, P1109, DOI 10.1101/gr.118992.110
   Lukk M, 2010, NAT BIOTECHNOL, V28, P322, DOI 10.1038/nbt0410-322
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nielsen TO, 2002, LANCET, V359, P1301, DOI 10.1016/S0140-6736(02)08270-3
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Oti M, 2007, CLIN GENET, V71, P1, DOI 10.1111/j.1399-0004.2006.00708
   Pesquita C, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-S5-S4
   Pesquita C, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000443
   Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
   Resnik P, 1995, INT JOINT CONF ARTIF, P448
   Robinson PN, 2008, AM J HUM GENET, V83, P610, DOI 10.1016/j.ajhg.2008.09.017
   Robinson PN, GENOME RES, V24, P340
   Rossin EJ, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001273
   Ruepp A, 2010, NUCLEIC ACIDS RES, V38, pD497, DOI 10.1093/nar/gkp914
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Schaner ME, 2005, MOL CANCER, V4, DOI 10.1186/1476-4598-4-26
   Shyamsundar R, 2005, GENOME BIOL, V6, DOI 10.1186/gb-2005-6-3-r22
   Stark C, 2011, NUCLEIC ACIDS RES, V39, pD698, DOI 10.1093/nar/gkq1116
   Steinberg J, AM J HUM GENET, V93, P825
   Su AI, 2004, P NATL ACAD SCI USA, V101, P6062, DOI 10.1073/pnas.0400782101
   Szklarczyk D, 2011, NUCLEIC ACIDS RES, V39, pD561, DOI 10.1093/nar/gkq973
   Vockley J, 2000, MOL GENET METAB, V71, P10, DOI 10.1006/mgme.2000.3066
   Warde-Farley D, 2010, NUCLEIC ACIDS RES, V38, pW214, DOI 10.1093/nar/gkq537
   Webber C, 2011, CYTOGENET GENOME RES, V135, P277, DOI 10.1159/000331670
   Zapala MA, 2005, P NATL ACAD SCI USA, V102, P10357, DOI 10.1073/pnas.0503357102
NR 45
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD AUG
PY 2014
VL 10
IS 8
AR e1003815
DI 10.1371/journal.pcbi.1003815
PG 7
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA AO8AE
UT WOS:000341573600050
PM 25166029
ER

PT J
AU Sondenaa, E
   Helverschou, SB
   Steindal, K
   Rasmussen, K
   Nilson, B
   Nottestad, JA
AF Sondenaa, Erik
   Helverschou, Sissel Berge
   Steindal, Kari
   Rasmussen, Kirsten
   Nilson, Britta
   Nottestad, Jim Aage
TI VIOLENCE AND SEXUAL OFFENDING BEHAVIOR IN PEOPLE WITH AUTISM SPECTRUM
   DISORDER WHO HAVE UNDERGONE A PSYCHIATRIC FORENSIC EXAMINATION
SO PSYCHOLOGICAL REPORTS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; ASPERGERS-SYNDROME; CRIMINAL
   BEHAVIOR; PREVALENCE; PERSONALITY; JUVENILE; DEFICITS; SAMPLE; CRIME;
   RISK
AB The increased awareness of Autism Spectrum Disorders (ASD) over the last few decades as well as the potential association between ASD and off ending behaviors has spurred a need for increased research in this area. In order to explore any possible relationship between ASD and violent or sexual crime the present study examines all forensic examination reports over a 10-yr. period in Norway where the charged persons were diagnosed with ASD and charged with either a violent (N = 21) or a sexual (N = 12) offense. Differences between these two groups regarding previous contact with child welfare and confessions to the offense were found. There was also a tendency toward more severe mental health problems and less intellectual problems among the violent off enders than the sexual off enders.
C1 [Sondenaa, Erik] St Olavs Hosp, N-7440 Trondheim, Norway.
   [Sondenaa, Erik] Univ Coll Sor Trondelag, Trondheim, Norway.
   [Helverschou, Sissel Berge; Steindal, Kari; Nilson, Britta] Oslo Univ Hosp, Natl Autism Unit, Oslo, Norway.
   [Rasmussen, Kirsten] St Olavs Hosp, Trondheim, Norway.
   [Rasmussen, Kirsten; Nottestad, Jim Aage] NTNU Inst Psychol, Trondheim, Norway.
   [Sondenaa, Erik; Nottestad, Jim Aage] St Olavs Hosp, Dep Broset, N-7440 Trondheim, Norway.
RP Sondenaa, E (reprint author), St Olavs Hosp, Dep Broset, Postbox 1803, N-7440 Trondheim, Norway.
EM erik.sondenaa@ntnu.no
CR Allen D, 2008, J AUTISM DEV DISORD, V38, P748, DOI 10.1007/s10803-007-0442-9
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Arseneault L, 2000, ARCH GEN PSYCHIAT, V57, P979, DOI 10.1001/archpsyc.57.10.979
   Attwood Tony, 2006, COMPLETE GUIDE ASPER
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Barry-Walsh JB, 2004, J FORENSIC PSYCHI PS, V15, P96, DOI 10.1080/14789940310001638628
   Bjorkly S, 2009, AGGRESS VIOLENT BEH, V14, P306, DOI 10.1016/j.avb.2009.04.003
   Cheely CA, 2012, J AUTISM DEV DISORD, V42, P1856, DOI 10.1007/s10803-011-1427-2
   Driemeyer W, 2013, J FORENSIC SCI, V58, P711, DOI 10.1111/1556-4029.12086
   EKMAN P, 1976, ENVIRON PSYCH NONVER, V1, P56, DOI 10.1007/BF01115465
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Fazel S, 2006, AM J PSYCHIAT, V163, P1397, DOI 10.1176/appi.ajp.163.8.1397
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   GHAZIUDDIN M, 1991, J AUTISM DEV DISORD, V21, P349, DOI 10.1007/BF02207331
   Grann M, 2004, BRIT MED J, V328, P1233, DOI 10.1136/bmj.328.7450.1233
   Grondahl P, 2005, NORD J PSYCHIAT, V59, P92, DOI 10.1080/08039480510022927
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hare D. J., 1999, PRELIMINARY STUDY IN
   Haskins BG, 2006, J AM ACAD PSYCHIATRY, V34, P374
   HAW C., 2013, J INTELL DISABIL RES, V4, P24
   Helverschou SB, 2011, AUT CHILD PSYCHO, P53, DOI 10.1007/978-1-4419-8065-6_5
   Langstrom N, 2009, J INTERPERS VIOLENCE, V24, P1358, DOI 10.1177/0886260508322195
   LIST D., 2009, PSYCHIAT PSYCHOL LAW, V16, P16
   Losel F., 2012, AM J PREV MED, V43, P8
   Mouridsen SE, 2008, INT J OFFENDER THER, V52, P196, DOI 10.1177/0306624X07302056
   Mouridsen SE, 2012, RES AUTISM SPECT DIS, V6, P79, DOI 10.1016/j.rasd.2011.09.003
   Murphy D, 2003, J FORENSIC PSYCHI PS, V14, P506, DOI 10.1080/1478994031000152736
   MURPHY G. H., 2014, J AUTISM DEV DISORDE
   MURRIE D. C., 2002, INT J FORENSIC MENTA, V1, P59, DOI DOI 10.1080/14999013.2002.10471161
   NOTTESTAD J. A., 2012, TIDSSKRIFT NORSKE PS, V49, P958
   SCRAGG P, 1994, BRIT J PSYCHIAT, V165, P679, DOI 10.1192/bjp.165.5.679
   Silva JA, 2002, J FORENSIC SCI, V47, P1347
   Siponmaa L, 2001, J AM ACAD PSYCHIATRY, V29, P420
   SOTO M. C., 2010, PSYCHOL BULL, V136, P526
   STEINDAL K., 2010, ARBEIDSSOKERE MED AS
   SUTTON L. R., 2012, FOCUS AUTISM OTHER D, V28, P175
   TRUSCOTT D, 1993, PSYCHOL REP, V73, P657
   Valliant PM, 1997, PSYCHOL REP, V81, P483
   Woodbury-Smith MR, 2006, J FORENSIC PSYCHI PS, V17, P108, DOI 10.1080/14789940600589464
   Woodbury-Smith MR, 2005, J FORENSIC PSYCHI PS, V16, P747, DOI 10.1080/14789940500302554
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
   Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 42
TC 0
Z9 0
PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0033-2941
J9 PSYCHOL REP
JI Psychol. Rep.
PD AUG
PY 2014
VL 115
IS 1
BP 32
EP 43
DI 10.2466/16.15.PR0.115c16z5
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA AO7HB
UT WOS:000341522100005
PM 25073065
ER

PT J
AU Cafferkey, M
   Ahn, JW
   Flinter, F
   Ogilvie, C
AF Cafferkey, Michiala
   Ahn, Joo Wook
   Flinter, Frances
   Ogilvie, Caroline
TI Phenotypic Features in Patients With 15q11.2(BP1-BP2) Deletion: Further
   Delineation of an Emerging Syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE 15q11.2(BP1-BP2) deletion; array CGH; CNV; NIPA1
ID PRADER-WILLI-SYNDROME; COMPARATIVE GENOMIC HYBRIDIZATION;
   GLOBUS-PALLIDUS DYSFUNCTION; COPY NUMBER VARIATION; TEST IN-PLACE;
   DEVELOPMENTAL DELAY; RECURRENT MICRODELETIONS; ANGELMAN-SYNDROME;
   CRITICAL REGION; ARRAY CGH
AB 15q11.2 deletions flanked by BP1 and BP2 of the Prader-Willi/Angelman syndrome region have recently been linked to a range of neurodevelopment disorders including intellectual disability, speech and language delay, motor delay, autism spectrum disorders, epilepsy, and schizophrenia. Array CGH analysis of 14,605 patients referred for diagnostic cytogenetic testing found that 83 patients (0.57%) carried the 15q11.2(BP1-BP2) deletion. Phenotypic frequencies in the deleted cohort (n = 83) were compared with frequencies in the non-deleted cohort (n = 14,522); developmental delay, motor delay, and speech and language delay were all more prevalent in the deleted cohort. Notably, motor delay was significantly more common (OR = 6.37). These data indicate that developmental delay, motor delay, and speech and language delay are common clinical features associated with this deletion, providing substantial evidence to support this CNV as a susceptibility locus for a spectrum of neurodevelopmental disorders. (C) 2014 Wiley Periodicals, Inc.
C1 [Cafferkey, Michiala; Flinter, Frances; Ogilvie, Caroline] Kings Coll London, Dept Med & Mol Genet, London WC2R 2LS, England.
   [Ahn, Joo Wook; Flinter, Frances; Ogilvie, Caroline] Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England.
RP Ogilvie, C (reprint author), Guys & St Thomas NHS Fdn Trust, Dept Cytogenet, 5th Floor,Tower Wing,St Thomas St, London SE1 9RT, England.
EM caroline.ogilvie@genetics.kcl.ac.uk
CR Abdelmoity AT, 2012, J DEV BEHAV PEDIATR, V33, P570, DOI 10.1097/DBP.0b013e31826052ae
   Ahn JW, 2010, MOL CYTOGENET, V3, DOI 10.1186/1755-8166-3-9
   Ahn JW, 2013, MOL CYTOGENET, V6, DOI 10.1186/1755-8166-6-16
   Bittel DC, 2006, PEDIATRICS, V118, pE1276, DOI 10.1542/peds.2006.0424
   Bozdagi O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042422
   Burnside R, 2011, HUM GENET, V130, P517, DOI 10.1007/s00439-011-0970-4
   Butler MG, 2004, PEDIATRICS, V113, P565, DOI 10.1542/peds.113.3.565
   Chai JH, 2003, AM J HUM GENET, V73, P898, DOI 10.1086/378816
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
   Cook EH, 1997, AM J HUM GENET, V60, P928
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
   Doornbos M, 2009, EUR J MED GENET, V52, P108, DOI 10.1016/j.ejmg.2009.03.010
   Firth HV, 2011, DEV MED CHILD NEUROL, V53, P702, DOI 10.1111/j.1469-8749.2011.04032.x
   Francois C, 2004, BRAIN, V127, P2055, DOI 10.1093/brain/awh239
   Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
   Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
   Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
   Goytain A, 2008, AM J PHYSIOL-CELL PH, V295, pC944, DOI 10.1152/ajpcell.00091.2008
   Grabli D, 2004, BRAIN, V127, P2039, DOI 10.1093/brain/awh220
   Hartley SL, 2005, AM J MED GENET A, V136A, P140, DOI 10.1002/ajmg.a.30771
   Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   Madrigal I, 2012, GENE, V508, P92, DOI 10.1016/j.gene.2012.07.023
   Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
   Morrow EM, 2010, J AM ACAD CHILD PSY, V49, P1091, DOI 10.1016/j.jaac.2010.08.009
   Murthy SK, 2007, CYTOGENET GENOME RES, V116, P135, DOI 10.1159/000097433
   Rainier S, 2003, AM J HUM GENET, V73, P967, DOI 10.1086/378817
   Repetto GR, 1998, AM J MED GENET, V79, P82, DOI 10.1002/(SICI)1096-8628(19980901)79:2<82::AID-AJMG2>3.0.CO;2-P
   Rosenfeld JA, 2012, GENET MED, V15, P478
   Sahoo T, 2006, J MED GENET, V43, P512, DOI 10.1136/jmg.2005.036913
   Schenck A, 2001, P NATL ACAD SCI USA, V98, P8844, DOI 10.1073/pnas.151231598
   Shevell M, 2003, NEUROLOGY, V60, P367
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tropeano M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061365
   Tsang HTH, 2009, HUM MOL GENET, V18, P3805, DOI 10.1093/hmg/ddp324
   Varela MC, 2004, EUR J HUM GENET, V12, P987, DOI 10.1038/sj.ejhg.5201264
   von der Lippe C, 2011, EUR J MED GENET, V54, P357, DOI 10.1016/j.ejmg.2010.12.008
   Xiong Y, 2009, J CELL SCI, V122, P4218, DOI 10.1242/jcs.059196
NR 40
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD AUG
PY 2014
VL 164A
IS 8
BP 1916
EP 1922
DI 10.1002/ajmg.a.36554
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AN5YD
UT WOS:000340667900052
PM 24715682
ER

PT J
AU Mignon-Ravix, C
   Cacciagli, P
   Choucair, N
   Popovici, C
   Missirian, C
   Milh, M
   Megarbane, A
   Busa, T
   Julia, S
   Girard, N
   Badens, C
   Sigaudy, S
   Philip, N
   Villard, L
AF Mignon-Ravix, Cecile
   Cacciagli, Pierre
   Choucair, Nancy
   Popovici, Cornel
   Missirian, Chantal
   Milh, Mathieu
   Megarbane, Andre
   Busa, Tiffany
   Julia, Sophie
   Girard, Nadine
   Badens, Catherine
   Sigaudy, Sabine
   Philip, Nicole
   Villard, Laurent
TI Intragenic Rearrangements in X-Linked Intellectual Deficiency: Results
   of a-CGH in a Series of 54 Patients and Identification of TRPC5 and
   KLHL15 As Potential XLID Genes
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE X-linked intellectual disability; array CGH; TRPC5; KLHL15
ID NONSPECIFIC MENTAL-RETARDATION; CEREBELLAR HYPOPLASIA; XLMR GENES;
   DISABILITY; DELETION; CHANNEL; FAMILY; OPHN1; MUTATION; GROWTH
AB High-resolution array comparative genomic hybridization (a-CGH) enables the detection of intragenic rearrangements, such as single exon deletion or duplication. This approach can lead to the identification of new disease genes. We report on the analysis of 54 male patients presenting with intellectual deficiency (ID) and a family history suggesting X-linked (XL) inheritance or maternal skewed X-chromosome inactivation(XCI), using a home-made X-chromosome-specific microarray covering the whole human X-chromosome at high resolution. The majority of patients had whole genome array-CGH prior to the selection and we did not include large rearrangements such as MECP2 and FMR1 duplications. We identified four rearrangements considered as causative or potentially pathogenic, corresponding to a detection rate of 8%. Two CNVs affected known XLID genes and were therefore considered as causative (IL1RAPL1 and OPHN1 intragenic deletions). Two new CNVs were considered as potentially pathogenic as they affected interesting candidates for ID. The first CNV is a deletion of the first exon of the TRPC5 gene, encoding a cation channel implicated in dendrite growth and patterning, in a child presenting with ID and an autism spectrum disorder (ASD). The second CNV is a partial deletion of KLHL15, in a patient with severe ID, epilepsy, and anomalies of cortical development. In both cases, in spite of strong arguments for clinical relevance, we were not able at this stage to confirm pathogenicity of the mutations, and the causality of the variants identified in XLID remains to be confirmed. (C) 2014 Wiley Periodicals, Inc.
C1 [Mignon-Ravix, Cecile; Cacciagli, Pierre; Choucair, Nancy; Milh, Mathieu; Megarbane, Andre; Badens, Catherine; Philip, Nicole; Villard, Laurent] INSERM, UMR S 910, F-13258 Marseille, France.
   [Mignon-Ravix, Cecile; Cacciagli, Pierre; Choucair, Nancy; Milh, Mathieu; Megarbane, Andre; Girard, Nadine; Badens, Catherine; Philip, Nicole; Villard, Laurent] Aix Marseille Univ, GMGF, Marseille, France.
   [Cacciagli, Pierre; Popovici, Cornel; Missirian, Chantal; Busa, Tiffany; Badens, Catherine; Sigaudy, Sabine; Philip, Nicole] Hop Enfants La Timone, Dept Genet Med & Biol Cellulaire, Marseille, France.
   [Choucair, Nancy; Megarbane, Andre] Univ St Joseph, Unite Genet Med, Beirut, Lebanon.
   [Choucair, Nancy; Megarbane, Andre] Univ St Joseph, Lab Associe INSERM, Unite UMR S 910, Pole Technol Sante, Beirut, Lebanon.
   [Milh, Mathieu] Hop Enfants La Timone, Serv Neurol Pediat, Marseille, France.
   [Julia, Sophie] Hop Purpan, Serv Genet Med, Toulouse, France.
   [Girard, Nadine] Hop Enfants La Timone, Serv Neuroradiol, Marseille, France.
RP Villard, L (reprint author), Fac Med La Timone, Inserm UMR S 910, 27 Bd Jean Moulin, F-13385 Marseille 5, France.
EM laurent.villard@univ-amu.fr
RI POPOVICI, Cornel/A-2027-2009
OI POPOVICI, Cornel/0000-0001-8226-3127
FU INSERM; Aix Marseille University
FX Grant sponsor: INSERM; Grant sponsor: Aix Marseille University.
CR Alesi V, 2012, GENE, V505, P384, DOI 10.1016/j.gene.2012.05.031
   Al-Owain M, 2011, CLIN GENET, V79, P363, DOI 10.1111/j.1399-0004.2010.01462.x
   Barone C, 2013, AM J MED GENET A, V161A, P1381, DOI 10.1002/ajmg.a.35860
   Behnecke A, 2011, AM J MED GENET A, V155A, P372, DOI 10.1002/ajmg.a.33656
   Bergmann C, 2003, BRAIN, V126, P1537, DOI 10.1093/brain/awg173
   Carrie A, 1999, NAT GENET, V23, P25
   Chiurazzi P, 2008, EUR J HUM GENET, V16, P422, DOI 10.1038/sj.ejhg.5201994
   des Portes V, 1999, AM J MED GENET, V85, P263, DOI 10.1002/(SICI)1096-8628(19990730)85:3<263::AID-AJMG15>3.0.CO;2-0
   Freichel M, 2005, J PHYSIOL-LONDON, V567, P59, DOI 10.1113/jphysiol.2005.092999
   Froyen G, 2007, HUM MUTAT, V28, P1034, DOI 10.1002/humu.20564
   Gecz J, 2009, TRENDS GENET, V25, P308, DOI 10.1016/j.tig.2009.05.002
   Gillardon F, 2009, J NEUROCHEM, V110, P1514, DOI 10.1111/j.1471-4159.2009.06235.x
   Gu XX, 1996, J MED GENET, V33, P52, DOI 10.1136/jmg.33.1.52
   He ZH, 2012, J NEUROSCI, V32, P9383, DOI 10.1523/JNEUROSCI.6363-11.2012
   Heo DK, 2012, CELL SIGNAL, V24, P899, DOI 10.1016/j.cellsig.2011.12.011
   Isrie M, 2012, EUR J MED GENET, V55, P577, DOI 10.1016/j.ejmg.2012.05.005
   Kaczmarek JS, 2012, P NATL ACAD SCI USA, V109, P7888, DOI 10.1073/pnas.1205869109
   Lubs HA, 2012, AM J HUM GENET, V90, P579, DOI 10.1016/j.ajhg.2012.02.018
   Lugtenberg D, 2007, GENET MED, V9, P560, DOI 10.1097/GIM.0b013e318149e647
   Madrigal I, 2008, J INTELL DISABIL RES, V52, P190, DOI 10.1111/j.1365-2788.2007.00997.x
   Nawara M, 2008, AM J MED GENET A, V146A, P3167, DOI 10.1002/ajmg.a.32613
   Oberg EA, 2012, J BIOL CHEM, V287, P43378, DOI 10.1074/jbc.M112.420281
   Phelan KD, 2013, MOL PHARMACOL, V83, P429, DOI 10.1124/mol.112.082271
   Piton A, 2011, Mol Psychiatry, V16, P867, DOI 10.1038/mp.2010.54
   Piton A, 2013, AM J HUM GENET, V93, P368, DOI 10.1016/j.ajhg.2013.06.013
   Poulain FE, 2010, MOL CELL NEUROSCI, V43, P15, DOI 10.1016/j.mcn.2009.07.012
   Puram SV, 2011, GENE DEV, V25, P2659, DOI 10.1101/gad.174060.111
   Riccio A, 2009, CELL, V137, P761, DOI 10.1016/j.cell.2009.03.039
   Rio M, 2010, EUR J HUM GENET, V18, P285, DOI 10.1038/ejhg.2009.159
   Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
   Ropers HH, 2005, NAT REV GENET, V6, P46, DOI 10.1038/nrg1501
   Rovelet-Lecrux A, 2009, HUM MUTAT, V30, pE591, DOI 10.1002/humu.20979
   Santos-Reboucas CB, 2014, EUR J HUM GENET, V22, P644, DOI 10.1038/ejhg.2013.216
   Shin HY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010359
   Sossey-Alaoui K, 1999, GENOMICS, V60, P330, DOI 10.1006/geno.1999.5924
   Sun XO, 2011, CELL CYCLE, V10, P3929, DOI 10.4161/cc.10.22.18106
   Tarpey PS, 2009, NAT GENET, V41, P535, DOI 10.1038/ng.367
   Van Esch H, 2005, AM J HUM GENET, V77, P442, DOI 10.1086/444549
   Villard L, 2001, J MED GENET, V38, P435, DOI 10.1136/jmg.38.7.435
   Xie R, 2011, J BIOL CHEM, V286, P10367, DOI 10.1074/jbc.M110.206532
   Zanni G, 2005, NEUROLOGY, V65, P1364, DOI 10.1212/01.wnl.0000182813.94713.ee
NR 41
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD AUG
PY 2014
VL 164A
IS 8
BP 1991
EP 1997
DI 10.1002/ajmg.a.36602
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AN5YD
UT WOS:000340667900061
PM 24817631
ER

PT J
AU Filges, I
   Sparagana, S
   Sargent, M
   Selby, K
   Schlade-Bartusiak, K
   Lueder, GT
   Robichaux-Viehoever, A
   Schlaggar, BL
   Shimony, JS
   Shinawi, M
AF Filges, Isabel
   Sparagana, Steven
   Sargent, Michael
   Selby, Kathryn
   Schlade-Bartusiak, Kamilla
   Lueder, Gregg T.
   Robichaux-Viehoever, Amy
   Schlaggar, Bradley L.
   Shimony, Joshua S.
   Shinawi, Marwan
TI Brain MRI Abnormalities and Spectrum of Neurological and Clinical
   Findings in Three Patients With Proximal 16p11.2 Microduplication
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE 16p11.2; microduplication; T2-hyperintensity; MRI; neurological
ID CHROMOSOME 16P11.2; AUTISM; PHENOTYPES; DISORDERS; REARRANGEMENTS;
   MICRODELETION; EXPRESSION; DELETIONS; DOSAGE
AB The phenotype of recurrent similar to 600 kb microdeletion and microduplication on proximal 16p11.2 is characterized by a spectrum of neurodevelopmental impairments including developmental delay and intellectual disability, epilepsy, autism and psychiatric disorders which are all subject to incomplete penetrance and variable expressivity. A variety of brain MRI abnormalities were reported in patients with 16p11.2 rearrangements, but no systematic correlation has been studied among patients with similar brain anomalies, their neurodevelopmental and clinical phenotypes. We present three patients with the proximal 16p11.2 microduplication exhibiting significant developmental delay, anxiety disorder and other variable clinical features. Our patients have abnormal brain MRI findings of cerebral T2 hyperintense foci (3/3) and ventriculomegaly (2/3). The neuro-radiological or neurological findings in two cases prompted an extensive diagnostic work-up. One patient has exhibited neurological regression and progressive vision impairment and was diagnosed with juvenile neuronal ceroid-lipofuscinosis. We compare the clinical course and phenotype of these patients in regard to the clinical significance of the cerebral lesions and the need for MRI surveillance. We conclude that in all three patients the lesions were not progressive, did not show any sign of malignant transformation and could not be correlated to specific clinical features. We discuss potential etiologic mechanisms that may include overexpression of genes within the duplicated region involved in control of cell proliferation and complex molecular mechanisms such as the MAPK/ERK pathway. Systematic studies in larger cohorts are needed to confirm our observation and to establish the prevalence and clinical significance of these neuroanatomical abnormalities in patients with 16p11.2 duplications. (C) 2014 Wiley Periodicals, Inc.
C1 [Filges, Isabel] Univ British Columbia, Dept Med Genet, BC Childrens & Womens Hosp, Child & Family Res Inst, Vancouver, BC, Canada.
   [Filges, Isabel] Univ Basel Hosp, Dept Biomed, Div Med Genet, CH-4031 Basel, Switzerland.
   [Sparagana, Steven] Texas Scottish Rite Hosp Children, Dept Pediat Neurol, Dallas, TX 75219 USA.
   [Sargent, Michael] Univ British Columbia, Dept Radiol, Vancouver, BC, Canada.
   [Selby, Kathryn] Univ British Columbia, Dept Pediat, Div Pediat Neurol, Vancouver, BC V6T 1W5, Canada.
   [Schlade-Bartusiak, Kamilla] Univ British Columbia, Dept Pathol & Lab Med, Child & Family Res Inst, Vancouver, BC V5Z 1M9, Canada.
   [Lueder, Gregg T.] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA.
   [Lueder, Gregg T.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
   [Robichaux-Viehoever, Amy; Schlaggar, Bradley L.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
   [Shimony, Joshua S.] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA.
   [Shinawi, Marwan] Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, St Louis, MO 63110 USA.
RP Filges, I (reprint author), BC Childrens & Womens Hosp, Dept Med Genet, Box 153,4480 Oak St, Vancouver, BC V6H 3V4, Canada.
EM Isabel.Filges@unibas.ch
FU Swiss Foundation for Grants in Biology; Medicine/Swiss National Science
   Foundation (SFGBM/SNSF); Freie Akademische Gesellschaft (FAG) Basel
FX Grant sponsor: Swiss Foundation for Grants in Biology; Grant sponsor:
   Medicine/Swiss National Science Foundation (SFGBM/SNSF); Grant sponsor:
   Freie Akademische Gesellschaft (FAG) Basel.
CR Baxter Robert C, 2013, J Cell Commun Signal, V7, P179, DOI 10.1007/s12079-013-0203-9
   Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
   Fernandez BA, 2010, J MED GENET, V47, P195, DOI 10.1136/jmg.2009.069369
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Horev G, 2011, P NATL ACAD SCI USA, V108, P17076, DOI 10.1073/pnas.1114042108
   Ingermann AR, 2010, J BIOL CHEM, V285, P30233, DOI 10.1074/jbc.M110.122226
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Kim BS, 2002, AM J NEURORADIOL, V23, P1674
   Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
   Kwiatkowski DJ, 2005, HUM MOL GENET, V14, pR251, DOI 10.1093/hmg/ddi260
   Luo R, 2012, AM J HUM GENET, V91, P38, DOI 10.1016/j.ajhg.2012.05.011
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Moore TM, 2000, J BIOL CHEM, V275, P4311, DOI 10.1074/jbc.275.6.4311
   Muscal E, 2010, J RHEUMATOL, V37, P1768, DOI 10.3899/jrheum.090983
   Okamoto S, 2002, MOL BRAIN RES, V107, P89, DOI 10.1016/S0169-328X(02)00440-0
   Pebrel-Richard C, 2013, EUR J HUM GENET, V22, P369
   Rauen Katherine A, 2010, Am J Med Genet A, V152A, P4, DOI 10.1002/ajmg.a.33183
   Ray A, 2004, J IMMUNOL, V172, P5006
   Rosenfeld JA, 2010, J NEURODEV DISORD, V2, P26, DOI 10.1007/s11689-009-9037-4
   Schaaf CP, 2011, EUR J HUM GENET, V19, P152, DOI 10.1038/ejhg.2010.168
   Shimojima K, 2009, EUR J MED GENET, V52, P433, DOI 10.1016/j.ejmg.2009.09.007
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   Tartaglia M, 2011, BEST PRACT RES CL EN, V25, P161, DOI 10.1016/j.beem.2010.09.002
   VANHANEN SL, 1995, J CHILD NEUROL, V10, P444
   Walters RG, 2010, NATURE, V463, P671, DOI 10.1038/nature08727
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Wiszniewski W, 2013, AM J HUM GENET, V93, P197, DOI 10.1016/j.ajhg.2013.05.027
   Zihni C, 2007, J BIOL CHEM, V282, P6484, DOI 10.1074/jbc.M608336200
   Zufferey F, 2012, J MED GENET, V49, P660, DOI 10.1136/jmedgenet-2012-101203
NR 29
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD AUG
PY 2014
VL 164A
IS 8
BP 2003
EP 2012
DI 10.1002/ajmg.a.36605
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA AN5YD
UT WOS:000340667900063
PM 24891046
ER

PT J
AU Joosten, AV
   Safe, AP
AF Joosten, Annette V.
   Safe, Anneleise P.
TI Management strategies of mothers of school-age children with autism:
   Implications for practice
SO AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL
LA English
DT Article
DE autism spectrum disorder; family-centred practice; mothers; research
   related; self management; wellbeing
ID SELF-MANAGEMENT; CHRONIC ILLNESS; SOCIAL SUPPORT; MENTAL-HEALTH;
   PARENTS; CARE; STRESS; IMPACT; PROFESSIONALS; PERSPECTIVES
AB Background/aim: Mothering children with autism results in mothers spending more time on daily tasks as well as managing the disorder. The need for mothers to self-manage often increases when the child is school aged. Mothers develop strategies, and occupational therapists and other health professional rely on or expect mothers to be involved in meeting the extra needs of their children with autism and other family members. Little is known about the strategies adopted by the mothers. The aim of this study was to explore the strategies mothers used to manage their roles and emotions, and their child's behaviours.
   Method: In-depth individual interviews were conducted with seven mothers and data were analysed in this qualitative study using phenomenological analysis.
   Results: Findings revealed that the mothers had adopted strategies to manage their roles, their emotions and their child's behaviour. However, the strategies were often shaped by the expectations of others or circumstances beyond their control and at times added further to their stress.
   Conclusions: Mothers of children with autism developed strategies to self-manage their lives and their child's disorder. However, even when these strategies were effective, they sometimes placed further stress on the mothers. The mothers provided insights to how they coped but need help to consider the support they require and therapists need to consider the pressures of expecting mothers to self-manage their child's disorder, their own lives and their family. Family-centred practice emphasising collaboration with mothers needs to be maintained with school-aged children.
C1 [Joosten, Annette V.] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Occupat Therapy & Social Work, Perth, WA 6102, Australia.
   [Safe, Anneleise P.] Ctr Cerebral Palsy, Therapy Serv, Perth, WA, Australia.
RP Joosten, AV (reprint author), Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Occupat Therapy & Social Work, Perth, WA 6102, Australia.
EM a.joosten@curtin.edu.au
CR (APA) APA, 2000, DIAGN STAT MAN MENT
   Barker-Dunbar S., 2006, OCCUPATIONAL THERAPY, V20, P51
   Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
   Bodenheimer T, 2002, JAMA-J AM MED ASSOC, V288, P2469, DOI 10.1001/jama.288.19.2469
   Bourke-Taylor H, 2010, AUST OCCUP THER J, V57, P127, DOI 10.1111/j.1440-1630.2009.00817.x
   Bourke-Taylor H, 2012, RES DEV DISABIL, V33, P1732, DOI 10.1016/j.ridd.2012.04.011
   Bourke-Taylor H., 2010, J PAEDIATR CHILD H, V48, P153
   Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
   BURTON P, 2008, J SOCIOECON, V0037
   Carpenter C., 2013, RES METHODS HLTH FDN, P115
   Clifford T, 2013, J AUTISM DEV DISORD, V43, P179, DOI 10.1007/s10803-012-1561-5
   Corbin JM, 1988, UNENDING WORK CARE M
   Creswell J. W., 2007, QUALITATIVE INQUIRY
   Crowe TK, 2006, AM J OCCUP THER, V60, P194
   Eisenhower AS, 2009, SOC SCI MED, V68, P89, DOI 10.1016/j.socscimed.2008.09.033
   Espe-Sherwindt M., 2008, SUPPORT LEARNING, V23, P136, DOI DOI 10.1111/J.1467-
   Fingerhut PE, 2013, AM J OCCUP THER, V67, P228, DOI 10.5014/ajot.2013.006957
   Gallant MP, 2003, HEALTH EDUC BEHAV, V30, P170, DOI 10.1177/1090198102251030
   Gray DE, 2006, J INTELL DISABIL RES, V50, P970, DOI 10.1111/j.1365-2788.2006.00933.x
   Guest G, 2006, FIELD METHOD, V18, P59, DOI 10.1177/1525822X05279903
   Leiter V, 2004, SOC SCI MED, V58, P837, DOI 10.1016/S0277-9536(03)00258-2
   Lorig KR, 2003, ANN BEHAV MED, V26, P1, DOI 10.1207/S15324796ABM2601_01
   Lysack C., 2006, RES OCCUPATIONAL THE, P341
   MacKean GL, 2005, HEALTH EXPECT, V8, P74, DOI 10.1111/j.1369-7625.2005.00319.x
   Montes G, 2007, PEDIATRICS, V119, pE1040, DOI 10.1542/peds.2006-2819
   Myers BJ, 2009, RES AUTISM SPECT DIS, V3, P670, DOI 10.1016/j.rasd.2009.01.004
   Newman S, 2004, LANCET, V364, P1523, DOI 10.1016/S0140-6736(04)17277-2
   Osborne LA, 2008, AUTISM, V12, P309, DOI 10.1177/1362361307089517
   Pisula E, 2007, J APPL RES INTELLECT, V20, P274, DOI 10.1111/j.1468-3148.2006.00342.x
   Primeau L. A., 2004, MOTHERING OCCUPATION
   Read J., 2000, DISABILITY FAMILY SO
   Rosenbaum P., 1998, PHYS OCCUPATIONAL TH, V18, P1, DOI DOI 10.1300/J006V18N01_01
   Safe A, 2012, J INTELLECT DEV DIS, V37, P294, DOI 10.3109/13668250.2012.736614
   Sharpley CF, 1997, J INTELLECT DEV DIS, V22, P19, DOI 10.1080/13668259700033261
   Smith J. A., 2008, QUALITATIVE PSYCHOL, P53
   Starks H, 2007, QUAL HEALTH RES, V17, P1372, DOI 10.1177/1049732307307031
   Strauss A., 1973, SOCIETY, V19, P33
   Wagner EH, 2001, HEALTH AFFAIR, V20, P64, DOI 10.1377/hlthaff.20.6.64
   White C, 2013, AUST OCCUP THER J, V60, P20, DOI 10.1111/1440-1630.12023
   Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
   Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x
NR 41
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0045-0766
EI 1440-1630
J9 AUST OCCUP THER J
JI Aust. Occup. Ther. J.
PD AUG
PY 2014
VL 61
IS 4
BP 249
EP 258
DI 10.1111/1440-1630.12116
PG 10
WC Rehabilitation
SC Rehabilitation
GA AO1UF
UT WOS:000341099700006
PM 24499184
ER

PT J
AU Geurts, HM
   van den Bergh, SFWM
   Ruzzano, L
AF Geurts, Hilde M.
   van den Bergh, Sanne F. W. M.
   Ruzzano, Laura
TI Prepotent Response Inhibition and Interference Control in Autism
   Spectrum Disorders: Two Meta-Analyses
SO AUTISM RESEARCH
LA English
DT Article
DE ASD; autism; inhibition; interference; cognitive control; meta-analysis
ID HIGH-FUNCTIONING AUTISM; DEFICIT HYPERACTIVITY DISORDER; LATENT-VARIABLE
   ANALYSIS; CHOICE REACTION-TIME; COGNITIVE CONTROL; EXECUTIVE FUNCTION;
   NEURODEVELOPMENTAL DISORDERS; IMPAIRED COGNITION; WORKING-MEMORY;
   STOP-SIGNAL
AB There is a substantial amount of data providing evidence for, but also against the hypothesis that individuals with autism spectrum disorders (ASD) encounter inhibitory control deficits. ASD is often associated with interference control deficits rather than prepotent response inhibition. Moreover, the developmental trajectory for these inhibitory control processes is hypothesized to differ in ASD as compared to typical development. In efforts to gain a more comprehensive perspective of inhibition in ASD, separate quantitative analysis for prepotent response inhibition studies and interference control studies were conducted. Together, these two meta-analyses included 41 studies with a combined sample size of 1,091 people with ASD (M age 14.8 years), and 1,306 typically developing (TD) controls (M age 13.8 years). The meta-analyses indicated that individuals with ASD show increased difficulties in prepotent response inhibition (effect size 0.55) and in interference control (effect size 0.31). In addition, age was a relevant moderator for prepotent response inhibition but not for interference control. Exploratory analyses revealed that when IQ was taken into account, heterogeneity considerably decreased among interference control studies but not among prepotent response inhibition. In contrast to the general belief, both prepotent response inhibition and interference control problems were observed in individuals with ASD. However, a large variation between studies was also found. Therefore, there remain factors beyond inhibition type, age, or IQ that significantly influence inhibitory control performance among individuals with ASD. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Geurts, Hilde M.] Univ Amsterdam, Dept Psychol Brain & Cognit, NL-1018 XA Amsterdam, Netherlands.
   [Geurts, Hilde M.; van den Bergh, Sanne F. W. M.; Ruzzano, Laura] Dr Leo Kannerhuis, Res & Dev, Ctr Autism, Amsterdam, Netherlands.
   [Geurts, Hilde M.; van den Bergh, Sanne F. W. M.; Ruzzano, Laura] Dutch Autism & ADHD Res Ctr Arc, Amsterdam, Netherlands.
   [Geurts, Hilde M.] Univ Amsterdam, Cognit Sci Ctr Amsterdam, NL-1018 XA Amsterdam, Netherlands.
RP Geurts, HM (reprint author), Univ Amsterdam, Dept Psychol, Dutch Autism & ADHD Res Ctr ARC, Weesperpl 4, NL-1018 XA Amsterdam, Netherlands.
EM H.M.Geurts@uva.nl
FU VIDI grant, Netherlands Organization for Scientific Research (NWO)
   [452-10-003]
FX This work is part of the research program "Autism and Aging: A Double
   Jeopardy, which is financed (VIDI grant number 452-10-003) by the
   Netherlands Organization for Scientific Research (NWO). Dr. Geurts,
   M.Sc. van den Bergh, and M.Sc. Ruzzano reported no biomedical financial
   interests or potential conflicts of interest.
CR Adams NC, 2009, J AUTISM DEV DISORD, V39, P1112, DOI 10.1007/s10803-009-0721-8
   Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3
   Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
   Ames CS, 2007, J AUTISM DEV DISORD, V37, P1761, DOI 10.1007/s10803-006-0309-5
   Aron AR, 2011, BIOL PSYCHIAT, V69, pE55, DOI 10.1016/j.biopsych.2010.07.024
   Ashwin C, 2006, PSYCHOL MED, V36, P835, DOI 10.1017/S0033291706007203
   Barneveld P. S., 2013, J INT NEUROPSYCH SOC, V19, P1
   Bishop DVM, 2005, AUTISM, V9, P29, DOI 10.1177/1362361305049028
   Brandimonte MA, 2011, MEMORY, V19, P56, DOI 10.1080/09658211.2010.535657
   Brian JA, 2003, J CHILD PSYCHOL PSYC, V44, P552, DOI 10.1111/1469-7610.00144
   Carter CS, 2005, SCHIZOPHRENIA BULL, V31, P810, DOI 10.1093/schbul/sbi046
   Casey BJ, 2001, CLIN NEUROSCI RES, V1, P267, DOI 10.1016/S1566-2772(01)00013-5
   Castellanos F. X., 2013, EUROPEAN CHILD ADOLE, V23, P69
   Chan AS, 2009, CLIN NEUROPHYSIOL, V120, P1107, DOI 10.1016/j.clinph.2009.04.002
   Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
   Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   Corbett BA, 2006, CHILD NEUROPSYCHOL, V12, P335, DOI 10.1080/09297040500350938
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   Dichter GS, 2008, PSYCHIAT RES-NEUROIM, V164, P185, DOI 10.1016/j.pscychresns.2007.12.005
   Dichter GS, 2007, NEUROIMAGE, V35, P1219, DOI 10.1016/j.neuroimage.2006.12.038
   Eagle DM, 2008, PSYCHOPHARMACOLOGY, V199, P439, DOI 10.1007/s00213-008-1127-6
   Egner T, 2008, TRENDS COGN SCI, V12, P374, DOI 10.1016/j.tics.2008.07.001
   ERIKSEN BA, 1974, PERCEPT PSYCHOPHYS, V16, P143, DOI 10.3758/BF03203267
   ESKES GA, 1990, J AUTISM DEV DISORD, V20, P61, DOI 10.1007/BF02206857
   Fairchild AJ, 2010, J SCHOOL PSYCHOL, V48, P53, DOI 10.1016/j.jsp.2009.09.001
   Fan J, 2003, NEUROIMAGE, V18, P42, DOI 10.1006/nimg.2002.1319
   Friedman NP, 2004, J EXP PSYCHOL GEN, V133, P101, DOI 10.1037/0096-3445.133.1.101
   Geurts H. M., 2011, J AUTISM DEV DISORD, V42, P665
   Geurts HM, 2008, J CHILD PSYCHOL PSYC, V49, P848, DOI 10.1111/j.1469-7610.2008.01916.x
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
   Geurts HM, 2009, J AUTISM DEV DISORD, V39, P1603, DOI 10.1007/s10803-009-0786-4
   Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Hedges L, 1985, STAT METHODS METAANA
   Henderson H, 2006, BRAIN COGNITION, V61, P96, DOI 10.1016/j.bandc.2005.12.009
   HUGHES C, 1993, DEV PSYCHOL, V29, P498, DOI 10.1037/0012-1649.29.3.498
   HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2
   Huizenga HM, 2011, BRIT J MATH STAT PSY, V64, P1, DOI 10.1348/000711010X522687
   Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
   Jahromi LB, 2013, RES AUTISM SPECT DIS, V7, P235, DOI 10.1016/j.rasd.2012.08.012
   Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019
   Johnston K, 2011, J AUTISM DEV DISORD, V41, P903, DOI 10.1007/s10803-010-1113-9
   Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
   Kilincaslan A, 2010, TURK PSIKIYATR DERG, V21, P289
   Kohls G, 2009, DEVELOPMENTAL SCI, V12, P614, DOI 10.1111/j.1467-7687.2009.00816.x
   Kuntsi J, 2001, J CHILD PSYCHOL PSYC, V42, P199, DOI 10.1017/S0021963001006709
   Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018
   Larson MJ, 2012, J CHILD PSYCHOL PSYC, V53, P440, DOI 10.1111/j.1469-7610.2011.02498.x
   Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
   Lemon JM, 2011, J AUTISM DEV DISORD, V41, P352, DOI 10.1007/s10803-010-1039-2
   LOGAN GD, 1984, J EXP PSYCHOL HUMAN, V10, P276, DOI 10.1037/0096-1523.10.2.276
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   MacDonald AW, 2002, J CLIN EXP NEUROPSYC, V24, P873, DOI 10.1076/jcen.24.7.873.8386
   Miyake A, 2012, CURR DIR PSYCHOL SCI, V21, P8, DOI 10.1177/0963721411429458
   Nigg JT, 2000, PSYCHOL BULL, V126, P220, DOI 10.1037//0033-2909.126.2.220
   Ogilvie JM, 2011, CRIMINOLOGY, V49, P1063, DOI 10.1111/j.1745-9125.2011.00252.x
   Ozonoff S, 1997, J AUTISM DEV DISORD, V27, P59, DOI 10.1023/A:1025821222046
   OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x
   Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
   Polderman TJC, 2009, NEUROPSYCHOLOGY, V23, P381, DOI 10.1037/a0014915
   Prinzmetal W, 2005, J EXP PSYCHOL GEN, V134, P73, DOI 10.1037/0096-3445.134.1.73
   Raymaekers R, 2006, CHILD NEUROPSYCHOL, V12, P349, DOI 10.1080/09297040600760457
   Raymaekers R, 2007, J CLIN EXP NEUROPSYC, V29, P418, DOI 10.1080/13803390600737990
   Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
   Russell J, 1999, J AUTISM DEV DISORD, V29, P103, DOI 10.1023/A:1023084425406
   Salthouse TA, 2010, BRAIN COGNITION, V73, P51, DOI 10.1016/j.bandc.2010.02.003
   Sanderson C, 2013, J AUTISM DEV DISORD, V43, P1065, DOI 10.1007/s10803-012-1650-5
   Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007
   Semrud-Clikeman M, 2010, J AUTISM DEV DISORD, V40, P1017, DOI 10.1007/s10803-010-0951-9
   SIMON JR, 1963, ERGONOMICS, V6, P99, DOI 10.1080/00140136308930679
   Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4
   Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
   Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001
   Soreni N, 2009, J ATTEN DISORD, V13, P137, DOI 10.1177/1087054708326110
   South M, 2010, BIOL PSYCHOL, V85, P242, DOI 10.1016/j.biopsycho.2010.07.009
   Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/h0054651
   Swick D, 2011, NEUROIMAGE, V56, P1655, DOI 10.1016/j.neuroimage.2011.02.070
   Tanguay PE, 2011, AM J PSYCHIAT, V168, P1142, DOI 10.1176/appi.ajp.2011.11071024
   Tye C., 2013, PSYCHOL MED, V15, P1
   Vaidya CJ, 2011, DEVELOPMENTAL SCI, V14, P911, DOI 10.1111/j.1467-7687.2011.01041.x
   Verte S, 2006, J NEUROSCI METH, V151, P5, DOI 10.1016/j.jneumeth.2005.08.023
   Viechtbauer W, 2010, J STAT SOFTW, V36, P1
   Wostmann NM, 2013, BRAIN COGNITION, V81, P82, DOI 10.1016/j.bandc.2012.09.010
   Xiao T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046569
   Yoran-Hegesh R, 2009, PSYCHIAT RES, V166, P35, DOI 10.1016/j.psychres.2007.11.015
NR 86
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 407
EP 420
DI 10.1002/aur.1369
PG 14
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300001
PM 24596300
ER

PT J
AU Sparaci, L
   Stefanini, S
   D'Elia, L
   Vicari, S
   Rizzolatti, G
AF Sparaci, Laura
   Stefanini, Silvia
   D'Elia, Lidia
   Vicari, Stefano
   Rizzolatti, Giacomo
TI What and Why Understanding in Autism Spectrum Disorders and Williams
   Syndrome: Similarities and Differences
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorders; Williams syndrome; social cognition; motor
   skills
ID YOUNG-CHILDREN; NEURAL BASIS; MOTOR; INFANTS; HYPERSOCIABILITY;
   INTENTIONS; DEFICIT; BRAIN; PERCEPTION; MECHANISMS
AB Children with autism spectrum disorders (ASD) and children with Williams syndrome (WS) show divergent social phenotypes, but also several similarities in their socio-cognitive deficits. Cross-syndrome direct comparisons could lead to a better understanding of mechanisms that determine deficits in social cognition in the two syndromes. A fundamental factor for social cognition is the ability to understand and predict others' actions (e. g. what action is being done and why it is being done when observing a goal-related act). Here we compared the understanding of others' actions in children with ASD, WS and in children with typical development. Comprehension of what motor act was being done and of why it was being done was assessed with or without contextual cueing using a computer-based task. The results showed that what understanding was impaired in the WS group, but not in the ASD group, which showed mental-age appropriate performance. Why understanding was impaired in both experimental groups. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Sparaci, Laura; Stefanini, Silvia; Rizzolatti, Giacomo] Univ Parma, Dept Neurosci, I-43100 Parma, Italy.
   [Sparaci, Laura] Natl Res Council CNR Italy, Inst Cognit Sci & Technol ISTC, I-00161 Rome, Italy.
   [Sparaci, Laura; D'Elia, Lidia; Vicari, Stefano] Bambino Gesu Childrens Hosp IRCCS, Rome, Italy.
   [Stefanini, Silvia] Local Hlth Unit AUSL, Dept Mental Hlth, Parma, Italy.
   [Rizzolatti, Giacomo] Italian Inst Technol, Parma Unit, Brain Ctr Social & Motor Cognit, Parma, Italy.
RP Sparaci, L (reprint author), Natl Res Council CNR Italy, Inst Cognit Sci & Technol ISTC, Via Nomentana 56, I-00161 Rome, Italy.
EM laura.sparaci@istc.cnr.it
FU Fondazione Monte Parma; ERC Advanced Grant "Cogsystems" [250013];
   Fondazione Handicap Dopodinoi, Onlus; MIUR-FIRB TOUM project
   [RBFR086HEW]
FX The work reported in this paper was supported by: Fondazione Monte Parma
   and ERC Advanced Grant "Cogsystems" (no. 250013) to G. R.; Fondazione
   Handicap Dopodinoi, Onlus to S. V.; MIUR-FIRB TOUM project (no.
   RBFR086HEW) to L. S. We are very grateful to the Italian Williams
   Syndrome Association (AISW) as well as to the Primary and Secondary
   Schools San Vitale-Fra' Salimbene Parma and San Francesco D'Assisi Rome
   for helping us in this study. We wish to thank Dr Patrizio Pasqualetti
   and Dr Pasquale Rinaldi for their help with statistical analyses. In
   particular, we wish to thank all the children and families who have
   participated in this research.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Asada K, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00247
   Bello A, 2004, NEUROPSYCHOLOGIA, V42, P201, DOI 10.1016/S0028-3932(03)00172-6
   Bello A, 2014, DEV PSYCHOL, V50, P504, DOI 10.1037/a0033375
   Bellugi U, 1999, NEUROREPORT, V10, P1653, DOI 10.1097/00001756-199906030-00006
   Boria S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005596
   Brock J, 2007, DEV PSYCHOPATHOL, V19, P97, DOI 10.1017/S095457940707006X
   Brock J., 2008, SOCIAL COGNITION DEV
   Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
   Csibra G., 2013, NAVIGATING SOCIAL WO
   CUTKOSKY MR, 1989, IEEE T ROBOTIC AUTOM, V5, P269, DOI 10.1109/70.34763
   Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270
   Doyle TF, 2004, AM J MED GENET A, V124A, P263, DOI 10.1002/ajmg.a.20416
   Dunn L. M., 1981, PEABODY PICTURE VOCA
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Fabbri-Destro M, 2009, EXP BRAIN RES, V192, P521, DOI 10.1007/s00221-008-1578-3
   Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138
   Forti S, 2011, RES AUTISM SPECT DIS, V5, P834, DOI 10.1016/j.rasd.2010.09.013
   Gazzaniga M., 2008, HUMAN SCI WHAT MAKES
   Grossmann T, 2007, SOC COGN AFFECT NEUR, V2, P284, DOI 10.1093/scan/nsm025
   Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
   Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
   Inui T, 2013, JPN PSYCHOL RES, V55, P99, DOI 10.1111/jpr.12004
   Izawa J, 2012, AUTISM RES, V5, P124, DOI 10.1002/aur.1222
   Jackowski AP, 2009, EUR J PAEDIATR NEURO, V13, P305, DOI 10.1016/j.ejpn.2008.07.002
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Jarvinen A., 2013, CURRENT OPINION NEUR, V23, P1
   Jones W, 2000, J COGNITIVE NEUROSCI, V12, P30, DOI 10.1162/089892900561968
   Klein-Tasman BP, 2011, J AUTISM DEV DISORD, V41, P341, DOI 10.1007/s10803-010-1060-5
   Klein-Tasman BP, 2003, DEV NEUROPSYCHOL, V23, P269, DOI 10.1207/S15326942DN231&2_12
   Lincoln AJ, 2007, J AM ACAD CHILD PSY, V46, P323, DOI 10.1097/chi.0b013e31802b9522
   Linkenauger SA, 2012, AUTISM RES, V5, P352, DOI 10.1002/aur.1248
   Lord C., 2005, AUTISM DIAGNOSTIC OB
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Martens MA, 2008, J CHILD PSYCHOL PSYC, V49, P576, DOI 10.1111/j.1469-7610.2008.01887.x
   Meyer-Lindenberg A, 2006, NAT REV NEUROSCI, V7, P380, DOI 10.1038/nrn1906
   Meyer-Lindenberg A, 2004, NEURON, V43, P623, DOI 10.1016/j.neuron.2004.08.014
   Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437
   Mostofsky SH, 2011, NEUROSCIENTIST, V17, P437, DOI 10.1177/1073858410392381
   Ogawa K, 2011, NEUROIMAGE, V56, P728, DOI 10.1016/j.neuroimage.2010.10.043
   Phillips AT, 2002, COGNITION, V85, P53, DOI 10.1016/S0010-0277(02)00073-2
   Roid G. H., 2002, LEITER R LEITER INT
   Southgate V, 2009, BIOL LETTERS, V5, P769, DOI 10.1098/rsbl.2009.0474
   Sparaci L, 2012, NEUROPSYCHOLOGIA, V50, P1639, DOI 10.1016/j.neuropsychologia.2012.03.019
   Tager-Flusberg H, 2006, SOC COGN AFFECT NEUR, V1, P175, DOI 10.1093/scan/nsl035
   Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
   Thoermer C, 2013, J EXP CHILD PSYCHOL, V116, P499, DOI 10.1016/j.jecp.2012.12.007
   Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
   Trinsempolou E., 2006, WORLD J PEDIATR, V2, P288
   Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
   von Hofsten C., 2012, FRONT INT NEUROSCI, V6, P1
   von Hofsten C, 2005, INFANCY, V8, P217, DOI 10.1207/s15327078in0803_2
   Walenski M, 2008, J AUTISM DEV DISORD, V38, P1395, DOI 10.1007/s10803-007-0513-y
   Woodward AL, 2000, PSYCHOL SCI, V11, P73, DOI 10.1111/1467-9280.00218
   Zalla T, 2010, EXP BRAIN RES, V201, P809, DOI 10.1007/s00221-009-2096-7
NR 55
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 421
EP 432
DI 10.1002/aur.1370
PG 12
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300002
PM 24604708
ER

PT J
AU Warner, G
   Moss, J
   Smith, P
   Howlin, P
AF Warner, Georgina
   Moss, Joanna
   Smith, Patrick
   Howlin, Patricia
TI Autism Characteristics and Behavioural Disturbances in similar to 500
   Children with Down's Syndrome in England and Wales
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; Down's syndrome; social communication
   questionnaire; strengths and difficulties questionnaire
ID FRAGILE-X-SYNDROME; SPECTRUM DISORDERS; DIFFICULTIES QUESTIONNAIRE;
   PREVALENCE; DIAGNOSIS; STRENGTHS; CHECKLIST; VALIDITY; PROJECT
AB Recent research shows that a significant minority of children with Down's syndrome (DS) also meet diagnostic criteria for an autism spectrum disorder (ASD). The present study investigated what proportion of children aged 6-15 years with a confirmed diagnosis of DS in England and Wales display autistic-type behaviours, and explored the characteristics of this group of children. The Social Communication Questionnaire (SCQ) was used to screen for autism characteristics and the Strengths and Difficulties Questionnaire (SDQ) to explore behavioural difficulties. The proportion of children who met the cut-off score for ASD on the SCQ (total score >= 15) was 37.7% (95% CI: 33.4-42.0%); for autism (total score >= 22) the proportion was 16.5% (95% CI: 13.2-19.8%). Children who met the cut-off for ASD were significantly more likely to be reported as having emotional symptoms, conduct problems and hyperactivity on the SDQ than children who scored well below cut-off (total score < 10). However, the profile of their autism characteristics on the SCQ was atypical compared with individuals with idiopathic ASD. The pervasiveness of ASD in children with DS in England and Wales is substantially higher than in the general population. These children also experience significantly greater behavioural problems than children with DS only. Early detection of autism characteristics is important for appropriate intervention. However, the unusual profile of autism characteristics in this group may affect the recognition of the disorder and hinder the implementation of appropriate interventions. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Warner, Georgina; Smith, Patrick; Howlin, Patricia] Kings Coll London, Inst Psychiat, Dept Psychol, London SE5 8AF, England.
   [Moss, Joanna] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
   [Moss, Joanna] UCL, Inst Cognit Neurosci, London, England.
   [Howlin, Patricia] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia.
RP Warner, G (reprint author), Kings Coll London, Inst Psychiat, Dept Psychol, London SE5 8AF, England.
EM georgina.warner@kcl.ac.uk
RI Moss, Jo/C-8812-2009
FU Baily Thomas Research Trust
FX We are grateful to the UK Down's Syndrome Association, and particularly
   to Stuart Mills, for their help with participant recruitment, and to
   Ellie Walsh and Jennie Cox for their help with the survey distribution,
   as well as to all the families who participated in the study. This study
   was funded by a PhD studentship from the Baily Thomas Research Trust.
CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Bolte S, 2008, J AM ACAD CHILD PSY, V47, P719, DOI 10.1097/CHI.0b013e31816c42bd
   Capone GT, 2005, AM J MED GENET A, V134A, P373, DOI 10.1002/ajmg.a.30622
   Carter JC, 2007, AM J MED GENET B, V144B, P87, DOI 10.1002/ajmg.b.30407
   Castillo H, 2008, J DEV BEHAV PEDIATR, V29, P89, DOI 10.1097/DBP.0b013e318165c78d
   DiGuiseppi C, 2010, J DEV BEHAV PEDIATR, V31, P181, DOI 10.1097/DBP.0b013e3181d5aa6d
   Eaves L.C., 2006, J DEV BEHAV PEDIATR, V27, P95, DOI DOI 10.1097/00004703-200604002-00007
   Finestack LH, 2010, J SPEECH LANG HEAR R, V53, P1334, DOI 10.1044/1092-4388(2010/09-0125)
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Freeman SB, 2007, PUBLIC HEALTH REP, V122, P62
   GHAZIUDDIN M, 1992, J INTELL DISABIL RES, V36, P449
   Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
   HOWLIN P, 1995, DEV MED CHILD NEUROL, V37, P406
   Ji NY, 2011, J INTELL DISABIL RES, V55, P1064, DOI 10.1111/j.1365-2788.2011.01465.x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lowenthal R, 2007, J AUTISM DEV DISORD, V37, P1394, DOI 10.1007/s10803-007-0374-4
   Magyar CI, 2012, J DEV BEHAV PEDIATR, V33, P134, DOI 10.1097/DBP.0b013e318240d3d9
   Molloy CA, 2009, J INTELL DISABIL RES, V53, P143, DOI 10.1111/j.1365-2788.2008.01138.x
   Morris JK, 2009, BMJ-BRIT MED J, V339, pb3794
   Moss J, 2013, AJIDD-AM J INTELLECT, V118, P55, DOI 10.1352/1944-7558-118.1.55
   Moss J, 2013, AUTISM, V17, P390, DOI 10.1177/1362361312442790
   Moss J., 2011, OXFORD HDB INTELLECT
   Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
   Office for National Statistics, 2007, ENGL IND DEPR REP
   Rasmussen P, 2001, DEV MED CHILD NEUROL, V43, P750, DOI 10.1017/S0012162201001372
   Rosner BA, 2004, J APPL RES INTELLECT, V17, P209, DOI 10.1111/j.1468-3148.2004.00200.x
   Rutter M., 1985, CHILD ADOLESCENT PSY
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Wiseman F. K., 2009, HUM MOL GENET, V18, P75
NR 33
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 433
EP 441
DI 10.1002/aur.1371
PG 9
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300003
PM 24664986
ER

PT J
AU Murphy, JW
   Foxe, JJ
   Peters, JB
   Molholm, S
AF Murphy, Jeremy W.
   Foxe, John J.
   Peters, Joanna B.
   Molholm, Sophie
TI Susceptibility to Distraction in Autism Spectrum Disorder: Probing the
   Integrity of Oscillatory Alpha-Band Suppression Mechanisms
SO AUTISM RESEARCH
LA English
DT Article
DE autism; EEG; oscillations; attention
ID SELECTIVE VISUAL-ATTENTION; EVENT-RELATED POTENTIALS; SPATIAL ATTENTION;
   VISUOSPATIAL ATTENTION; INNER SPEECH; FUNCTIONAL CONNECTIVITY; CORTICAL
   CONNECTIVITY; OCCIPITAL CORTEX; CHILDREN; EEG
AB When attention is directed to one information stream over another, the brain can be configured in advance to selectively process the relevant stream and suppress potentially distracting inputs. One key mechanism of suppression is through the deployment of anticipatory alpha-band (similar to 10 Hz) oscillatory activity, with greater alpha-band power observed in cortical regions that will ultimately process the distracting stream. Atypical attention has been implicated in autism spectrum disorder (ASD), including greater interference by distracting task-irrelevant inputs. Here we tested the integrity of these alpha-band mechanisms in ASD using an intersensory attention task. Electroencephalography (EEG) was recorded while participants were cued on a trial-by-trial basis to selectively deploy attention to the visual or auditory modality in anticipation of a target within the cued modality. Whereas typically developing (TD) children showed the predicted alpha-band modulation, with increased alpha-band power over parieto-occipital scalp when attention was deployed to the auditory compared with the visual modality, this differential pattern was entirely absent at the group level in the ASD cohort. Further, only the ASD group showed impaired performance due to the presence of task-irrelevant sensory information. These data suggest that impaired modulation of alpha-band activity plays a role in increased distraction from extraneous sensory inputs in ASD. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Murphy, Jeremy W.; Foxe, John J.; Peters, Joanna B.; Molholm, Sophie] Albert Einstein Coll Med, Sheryl & Daniel R Tishman Cognit Neurophysiol Lab, Childrens Evaluat & Rehabil Ctr, Dept Pediat, Bronx, NY 10461 USA.
   [Murphy, Jeremy W.; Foxe, John J.; Peters, Joanna B.; Molholm, Sophie] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA.
   [Murphy, Jeremy W.; Foxe, John J.; Molholm, Sophie] CUNY City Coll, Dept Psychol, Program Cognit Neurosci, New York, NY 10031 USA.
   [Murphy, Jeremy W.; Foxe, John J.; Molholm, Sophie] CUNY City Coll, Dept Biol, Program Cognit Neurosci, New York, NY 10031 USA.
   [Peters, Joanna B.] Yeshiva Univ, Ferkauf Grad Sch Psychol, Program Clin Psychol, Bronx, NY USA.
RP Molholm, S (reprint author), Albert Einstein Coll Med, Sheryl & Daniel R Tishman Cognit Neurophysiol Lab, Childrens Evaluat & Rehabil Ctr, Dept Pediat, Van Etten Bldg,Wing 1C,1225 Morris Pk Ave, Bronx, NY 10461 USA.
EM sophie.molholm@einstein.yu.edu
FU U.S. National Institute of Mental Health [MH085322]; Eunice Kennedy
   Shriver National Institute of Child Health & Human Development [NICHD
   P30 HD071593]
FX Primary funding for this work was provided by a grant from the U.S.
   National Institute of Mental Health (MH085322 to S. M and J.J.F). The
   Human Clinical Phenotyping Core, where the children enrolled in this
   study were clinically evaluated, is a facility of the Rose F. Kennedy
   Intellectual and Developmental Disabilities Research Center (IDDRC)
   which is funded through a center grant from the Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD P30
   HD071593).
CR Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3
   Banerjee S, 2011, J NEUROSCI, V31, P9923, DOI 10.1523/JNEUROSCI.4660-10.2011
   BELL AJ, 1995, NEURAL COMPUT, V7, P1129, DOI 10.1162/neco.1995.7.6.1129
   Benjamini Y, 2001, ANN STAT, V29, P1165
   Berger H., 1929, EUR ARCH PSY CLIN N, V87, P527, DOI DOI 10.1007/BF01797193
   Bollimunta A, 2011, J NEUROSCI, V31, P4935, DOI 10.1523/JNEUROSCI.5580-10.2011
   BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535
   Buschman TJ, 2012, NEURON, V76, P838, DOI 10.1016/j.neuron.2012.09.029
   Capotosto P, 2009, J NEUROSCI, V29, P5863, DOI 10.1523/JNEUROSCI.0539-09.2009
   Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331
   Chan AS, 2006, J CHILD NEUROL, V21, P391
   Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
   Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256
   CIESIELSKI KT, 1990, ELECTROEN CLIN NEURO, V75, P207, DOI 10.1016/0013-4694(90)90174-I
   CIESIELSKI KT, 1995, NEUROPSYCHOLOGIA, V33, P225, DOI 10.1016/0028-3932(94)00094-6
   Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
   CORBETTA M, 1993, J NEUROSCI, V13, P1202
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
   Delorme A, 2004, J NEUROSCI METH, V134, P9, DOI 10.1016/j.jneumeth.2003.10.009
   DESIMONE R, 1995, ANNU REV NEUROSCI, V18, P193, DOI 10.1146/annurev.ne.18.030195.001205
   de Vries M, 2012, J AUTISM DEV DISORD, V42, P2558, DOI 10.1007/s10803-012-1512-1
   Dockree PM, 2007, EUR J NEUROSCI, V25, P900, DOI 10.1111/j.1460-9568.2007.05324.x
   Doricchi F, 2003, NEUROREPORT, V14, P2239, DOI 10.1097/01.wnr.0000091132.75061.64
   ERIKSEN BA, 1974, PERCEPT PSYCHOPHYS, V16, P143, DOI 10.3758/BF03203267
   Foxe JJ, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00154
   Foxe JJ, 1998, NEUROREPORT, V9, P3929, DOI 10.1097/00001756-199812010-00030
   Fries P, 2001, SCIENCE, V291, P1560, DOI 10.1126/science.1055465
   Fu KMG, 2001, COGNITIVE BRAIN RES, V12, P145, DOI 10.1016/S0926-6410(01)00034-9
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Gomez-Ramirez M, 2011, J NEUROSCI, V31, P18556, DOI 10.1523/JNEUROSCI.2164-11.2011
   Gomez-Ramirez M, 2009, BRAIN TOPOGR, V22, P44, DOI 10.1007/s10548-008-0068-z
   Gomez-Ramirez M, 2007, CLIN NEUROPHARMACOL, V30, P25, DOI 10.1097/01.WNF.0000240940.13876.17
   Green D. M., 1966, SIGNAL DETECTION THE
   Hanslmayr S, 2007, NEUROIMAGE, V37, P1465, DOI 10.1016/j.neuroimage.2007.07.011
   Iarocci G, 2004, J AUTISM DEV DISORD, V34, P257, DOI 10.1023/B:JADD.0000029548.84041.69
   Isler JR, 2010, CLIN NEUROPHYSIOL, V121, P2035, DOI 10.1016/j.clinph.2010.05.004
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Kelly SP, 2009, EUR J NEUROSCI, V30, P2224, DOI [10.1111/j.1460-9568.2009.06980.x, 10.1111/j.1460-9568.2009.6980.x]
   Kelly SP, 2006, J NEUROPHYSIOL, V95, P3844, DOI 10.1152/jn.01234.2005
   Klimesch W, 2007, BRAIN RES REV, V53, P63, DOI 10.1016/j.brainresrev.2006.06.003
   Lazarev VV, 2010, CLIN NEUROPHYSIOL, V121, P145, DOI 10.1016/j.clinph.2009.10.010
   Lidstone JSM, 2009, J AUTISM DEV DISORD, V39, P1222, DOI 10.1007/s10803-009-0731-6
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015
   Mathewson KJ, 2012, CLIN NEUROPHYSIOL, V123, P1798, DOI 10.1016/j.clinph.2012.02.061
   MESULAM MM, 1981, ANN NEUROL, V10, P309, DOI 10.1002/ana.410100402
   Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051
   Miyake A, 2004, ACTA PSYCHOL, V115, P123, DOI 10.1016/j.actpsy.2003.12.004
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
   Ohta H, 2012, NEUROIMAGE, V61, P1176, DOI 10.1016/j.neuroimage.2012.03.042
   Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650
   Poljac E, 2010, Q J EXP PSYCHOL, V63, P401, DOI 10.1080/17470210902990803
   Reed P, 2012, J AUTISM DEV DISORD, V42, P947, DOI 10.1007/s10803-011-1324-8
   Remington AM, 2012, J ABNORM PSYCHOL, V121, P544, DOI 10.1037/a0027670
   Rihs TA, 2007, EUR J NEUROSCI, V25, P603, DOI 10.1111/j.1460-9568.2007.05278.x
   Roach BJ, 2008, SCHIZOPHRENIA BULL, V34, P907, DOI 10.1093/schbul/sbn093
   Romei V, 2010, J NEUROSCI, V30, P8692, DOI 10.1523/JNEUROSCI.0160-10.2010
   Ross LA, 2011, EUR J NEUROSCI, V33, P2329, DOI 10.1111/j.1460-9568.2011.07685.x
   Ross Lars A, 2007, Cereb Cortex, V17, P1147, DOI 10.1093/cercor/bhl024
   Sahyoun CP, 2010, BRAIN COGNITION, V73, P180, DOI 10.1016/j.bandc.2010.05.002
   Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x
   Snyder AC, 2010, J NEUROSCI, V30, P4024, DOI 10.1523/JNEUROSCI.5684-09.2010
   Stoet G, 2011, EUR J DEV PSYCHOL, V8, P244, DOI 10.1080/17405629.2010.492000
   Szczepanski SM, 2010, J NEUROSCI, V30, P148, DOI 10.1523/JNEUROSCI.3862-09.2010
   Teder-Salejarvi WA, 2005, COGNITIVE BRAIN RES, V23, P221, DOI 10.1016/j.cogbrainres.2004.10.021
   Thiebaut de Schotten M., 2005, SCIENCE, V309, P2226, DOI DOI 10.1126/SCIENCE.1116251
   Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006
   Thut G, 2006, J NEUROSCI, V26, P9494, DOI 10.1523/JNEUROSCI.0875-06.2006
   TOWNSEND J, 1994, J COGNITIVE NEUROSCI, V6, P220, DOI 10.1162/jocn.1994.6.3.220
   Uhlhaas Peter J, 2006, Neuron, V52, P155, DOI 10.1016/j.neuron.2006.09.020
   WAINWRIGHTSHARP JA, 1993, J AUTISM DEV DISORD, V23, P1, DOI 10.1007/BF01066415
   Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8
   Weschler D, 2011, WECHSLER ABBREVIATED
   Weschler D, 2003, WECHSLER INTELLIGENC
   Weschler D., 1999, WECHSLER ABBREVIATED
   WETHERILL GB, 1965, BRIT J MATH STAT PSY, V18, P1
   Whitehouse AJO, 2006, J CHILD PSYCHOL PSYC, V47, P857, DOI 10.1111/j.1469-7610.2006.01624.x
   Williams DM, 2010, J AUTISM DEV DISORD, V40, P907, DOI 10.1007/s10803-010-0936-8
   Worden MS, 2000, J NEUROSCI, V20, part. no.
   Yamagishi N, 2008, BRAIN RES, V1197, P115, DOI 10.1016/j.brainres.2007.12.063
NR 83
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 442
EP 458
DI 10.1002/aur.1374
PG 17
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300004
PM 24678054
ER

PT J
AU Smith, RM
   Banks, W
   Hansen, E
   Sadee, W
   Herman, GE
AF Smith, Ryan M.
   Banks, Wesley
   Hansen, Emily
   Sadee, Wolfgang
   Herman, Gail E.
TI Family-Based Clinical Associations and Functional Characterization of
   the Serotonin 2A Receptor Gene (HTR2A) in Autism Spectrum Disorder
SO AUTISM RESEARCH
LA English
DT Article
DE autism; serotonin; gene expression; HTR2A; rs6311; monoamine
ID DIAGNOSTIC OBSERVATION SCHEDULE; GENOME-WIDE ASSOCIATION; COPY NUMBER
   VARIATION; DE-NOVO MUTATIONS; 5-HT2A RECEPTOR; SYNAPTIC PATHOPHYSIOLOGY;
   MESSENGER-RNA; COMMON; CHILDREN; POLYMORPHISMS
AB The serotonin 2A receptor gene (HTR2A) harbors two functional single nucleotide polymorphisms (SNPs) that are frequent in populations of African and European descent; rs6311, which affects mRNA expression, and rs6314, which changes the amino acid sequence of the encoded protein and affects the signaling properties of the receptor. Multiple clinical associations support a role for these SNPs in cognitive and neuropsychiatric phenotypes, although studies in autism spectrum disorder (ASD) remain equivocal. Here, we tested transmission disequilibrium of rs6311 and rs6314 in a cohort of 158 ASD trios (simplex and multiplex), observing significant under-transmission of the minor "A" allele of rs6311 to offspring with ASD (permuted P = 0.0004). Consistent with our previous findings in the dorsolateral prefrontal cortex of unaffected individuals, rs6311/A decreases expression of HTR2A mRNA with an extended 5' untranslated region (UTR) in the frontopolar cortex in brain samples from 54 ASD patients and controls. Interpreting the clinical results in the context of our mRNA expression analysis, we speculate that any risk associated with rs6311 is conferred by greater expression of the long 5' UTR mRNA isoform. The current study corroborates earlier associations between rs6311 and ASD in a family study, supporting the hypothesis that rs6311 plays a modulatory role in ASD risk. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Smith, Ryan M.; Sadee, Wolfgang] Ohio State Univ, Dept Pharmacol, Coll Med, Ctr Pharmacogen, Columbus, OH 43210 USA.
   [Banks, Wesley; Hansen, Emily; Herman, Gail E.] Ohio State Univ, Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, Columbus, OH 43210 USA.
   [Banks, Wesley; Hansen, Emily; Herman, Gail E.] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA.
   [Sadee, Wolfgang] Ohio State Univ, Dept Pharm, Columbus, OH 43210 USA.
   [Sadee, Wolfgang] Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA.
   [Sadee, Wolfgang] Ohio State Univ, Dept Human Genet Internal Med, Columbus, OH 43210 USA.
   [Sadee, Wolfgang] Ohio State Univ, Dept Environm Hlth Sci, Columbus, OH 43210 USA.
RP Smith, RM (reprint author), Ohio State Univ, Dept Pharmacol, 5184A Graves Hall,333 W10th Ave, Columbus, OH 43210 USA.
EM Ryan.Smith2@osumc.edu
FU National Institute of General Medical Sciences [U01GM092655]; United
   States Air Force Department of Defense [FA7014-09-2-0004,
   FA8650-12-2-6359]
FX The authors declare no competing interests. This work was supported by
   the National Institute of General Medical Sciences (U01GM092655 to W.
   S.) and the United States Air Force Department of Defense
   (FA7014-09-2-0004 and FA8650-12-2-6359 to Gail E. Herman). We are
   grateful to all the families participating in the CORA registry. We
   thankfully acknowledge Harvard Brain Tissue Resource Center and the
   NICHD Brain and Tissue Bank for providing brain tissues, granted to Ryan
   M. Smith and Wolfgang Sadee from the Autism Tissue Program, made
   possible by the donations of generous family members.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   Arranz MJ, 1998, SCHIZOPHR RES, V32, P93, DOI 10.1016/S0920-9964(98)00032-2
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159
   Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
   Beversdorf DQ, 2012, J NEUROPSYCH CLIN N, V24, P191, DOI 10.1176/appi.neuropsych.11080202
   Bray NJ, 2004, MOL PSYCHIATR, V9, P109, DOI 10.1038/sj.mp.4001366
   Cho IH, 2007, BRAIN RES, V1139, P34, DOI 10.1016/j.brainres.2007.01.002
   Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
   Connolly JJ, 2013, CHILD DEV, V84, P17, DOI 10.1111/j.1467-8624.2012.01838.x
   Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
   COOK EH, 1993, LIFE SCI, V52, P2005, DOI 10.1016/0024-3205(93)90685-V
   Cottrell CE, 2011, AUTISM RES, V4, P189, DOI 10.1002/aur.184
   Davies MA, 2006, PHARMACOGENOMICS J, V6, P42, DOI 10.1038/sj.tpj.6500342
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Fukuda Y, 2006, BIOL PSYCHIAT, V60, P1331, DOI 10.1016/j.biopsych.2006.06.024
   Girgis RR, 2011, PSYCHIAT RES-NEUROIM, V194, P230, DOI 10.1016/j.pscychresns.2011.04.007
   Goldberg J, 2009, J AUTISM DEV DISORD, V39, P97, DOI 10.1007/s10803-008-0604-4
   Gorwood P, 2003, EUR J PHARMACOL, V480, P163, DOI 10.1016/j.ejphar.2003.08.103
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Guhathakurta S, 2009, NEUROCHEM INT, V55, P754, DOI 10.1016/j.neuint.2009.07.008
   Hazelwood LA, 2004, MOL PHARMACOL, V66, P1293
   Herault J, 1996, PSYCHIAT RES, V65, P33, DOI 10.1016/0165-1781(96)02882-X
   Hranilovic D, 2009, J NEURAL TRANSM, V116, P493, DOI 10.1007/s00702-009-0192-2
   Hranilovic D, 2010, PSYCHIAT RES, V178, P556, DOI 10.1016/j.psychres.2010.04.007
   Jakab RL, 1998, P NATL ACAD SCI USA, V95, P735, DOI 10.1073/pnas.95.2.735
   Kato M, 2010, MOL PSYCHIATR, V15, P473, DOI 10.1038/mp.2008.116
   Kazek B, 2010, ACTA NEUROBIOL EXP, V70, P232
   Kling A, 2008, ANN RHEUM DIS, V67, P1111, DOI 10.1136/ard.2007.074948
   Lee YH, 2012, RHEUMATOL INT, V32, P417, DOI 10.1007/s00296-010-1678-9
   Lerer B, 2005, INT J NEUROPSYCHOPH, V8, P411, DOI 10.1017/S1461145705005389
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
   Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x
   Marshall CR, 2012, METHODS MOL BIOL, V838, P115, DOI 10.1007/978-1-61779-507-7_5
   Martaskova D, 2009, FOLIA BIOL-PRAGUE, V55, P192
   Matsunami N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0052239
   MCBRIDE PA, 1989, ARCH GEN PSYCHIAT, V46, P213
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Polesskaya OO, 2002, J NEUROSCI RES, V67, P812, DOI 10.1002/jnr.10173
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Ramanathan S, 2009, AM J GERIAT PSYCHIAT, V17, P839, DOI 10.1097/JGP.0b013e3181ab8c3f
   Scott LJ, 2008, CNS DRUGS, V22, P259, DOI 10.2165/00023210-200822030-00006
   Smith RM, 2013, BIOL PSYCHIAT, V73, P546, DOI 10.1016/j.biopsych.2012.09.028
   Veenstra-VanderWeele J, 2002, AM J MED GENET, V114, P277, DOI 10.1002/ajmg.10192
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Zafeiriou DI, 2007, BRAIN DEV-JPN, V29, P257, DOI 10.1016/j.braindev.2006.09.003
NR 55
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 459
EP 467
DI 10.1002/aur.1383
PG 9
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300005
PM 24753316
ER

PT J
AU McCormick, C
   Hessl, D
   Macari, SL
   Ozonoff, S
   Green, C
   Rogers, SJ
AF McCormick, Carolyn
   Hessl, David
   Macari, Suzanne L.
   Ozonoff, Sally
   Green, Cherie
   Rogers, Sally J.
TI Electrodermal and Behavioral Responses of Children With Autism Spectrum
   Disorders to Sensory and Repetitive Stimuli
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; psychophysiology; sensory; repetitive
   behaviors
ID DEVELOPMENTAL DELAYS; YOUNG-CHILDREN; MISSING DATA; INDIVIDUALS;
   INTEGRATION; PATTERNS; MOTOR; AGE
AB Parents frequently report that their children with autism spectrum disorders (ASD) respond atypically to sensory stimuli. Repetitive behaviors are also part of the ASD behavioral profile. Abnormal physiological arousal may underlie both of these symptoms. Electrodermal activity (EDA) is an index of sympathetic nervous system arousal. The goals of this study were twofold: (1) to pilot methods for collecting EDA data in young children and (2) to examine hypothesized relationships among EDA, and sensory symptoms and repetitive behaviors in children with ASD as compared with children with typical development. EDA was recorded on 54 young children with ASD and on 33 children with typical development (TD) during a protocol that included baseline, exposure to sensory and repetitive stimuli, and play. Parents completed standardized questionnaires regarding their child's sensory symptoms and repetitive behaviors. Frequency and type of repetitive behavior during play was coded offline. Comparisons between EDA data for ASD and TD groups indicated no significant between-group differences in any measures. Parents of children with ASD reported more abnormal responses to sensory stimuli and more repetitive behaviors, but scores on these measures were not significantly correlated with EDA or with frequency of observed repetitive behaviors. Parent report of frequency and severity of sensory symptoms was significantly correlated with reports of repetitive behaviors in both groups. Although parents of children with ASD report high levels of sensory symptoms and repetitive behaviors, these differences are not related to measured EDA arousal or reactivity. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [McCormick, Carolyn; Hessl, David; Ozonoff, Sally; Rogers, Sally J.] Univ Calif Davis, MIND Inst, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
   [Macari, Suzanne L.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA.
   [Green, Cherie] La Trobe Univ, Olga Tennison Autism Res Ctr, Melbourne, Vic, Australia.
RP McCormick, C (reprint author), Univ Calif Davis, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM carolyn.mccormick@ucdmc.ucdavis.edu
FU UC Davis MIND Institute
FX This research was conducted as part of the Autism Phenome Project and
   supported by the UC Davis MIND Institute. We would like to acknowledge
   Cynthia Zierhut, Lisa Cochran, Susan Rumberg, and Lou Ann Barnett for
   their roles on the project, as well as Jennifer Bernstein and Olha
   Kalish for help with coding. We want to thank all of the families who
   made this research possible.
CR ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   Adrien J.L., 1992, INT J CHILD ADOLESCE, V55, P71
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Baranek GT, 2013, DEV PSYCHOPATHOL, V25, P307, DOI 10.1017/S0954579412001071
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
   BERNAL ME, 1970, PSYCHOPHYSIOLOGY, V7, P155, DOI 10.1111/j.1469-8986.1970.tb02222.x
   Bodfish J.W., 1998, REPETITIVE BEHAV SCA
   Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
   Boyd BA, 2009, RES AUTISM SPECT DIS, V3, P959, DOI 10.1016/j.rasd.2009.05.003
   Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124
   Brandwein AB, 2013, CEREB CORTEX, V23, P1329, DOI 10.1093/cercor/bhs109
   Cacioppo JT, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P1, DOI 10.2277/ 0521844711
   Dawson G., 1989, AUTISM NATURE DIAGNO, P49
   DesLauries A.M., 1969, YOUR CHILD IS ASLEEP
   Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
   Gabriels RL, 2008, RES AUTISM SPECT DIS, V2, P660, DOI 10.1016/j.rasd.2008.02.002
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530
   Ham J, 2008, DEV PSYCHOBIOL, V50, P626, DOI 10.1002/dev.20317
   Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724
   HUTT C, 1964, NATURE, V204, P908, DOI 10.1038/204908a0
   HUTT C, 1965, ANIM BEHAV, V13, P1, DOI 10.1016/0003-3472(65)90064-3
   Kanner L, 1943, NERV CHILD, V2, P217
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   LOVAAS I, 1987, J APPL BEHAV ANAL, V20, P45, DOI 10.1901/jaba.1987.20-45
   Lyndon S., 2013, J DEV PHYS DISABIL, V25, P149
   Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   McIntosh DN, 1999, DEV MED CHILD NEUROL, V41, P608, DOI 10.1017/S0012162299001267
   Miller LJ, 2007, AM J OCCUP THER, V61, P135
   Miller LJ, 1999, AM J MED GENET, V83, P268, DOI 10.1002/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.3.CO;2-B
   Mullen E, 1995, MULLEN SCALES EARLY
   Nunnally J. C., 1978, PSYCHOMETRIC THEORY
   OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
   Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402
   PETERSON RA, 1994, J CONSUM RES, V21, P381, DOI 10.1086/209405
   Rimland B., 1964, INFANTILE AUTISM
   Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Schoen SA, 2008, RES AUTISM SPECT DIS, V2, P417, DOI 10.1016/j.rasd.2007.09.002
   Schoen S.A., 2009, FRONTIERS INTEGRATIV, V3, P1, DOI DOI 10.3389/NEURO.07.029.2009
   STEVENS S, 1984, J AUTISM DEV DISORD, V14, P245, DOI 10.1007/BF02409577
   van Engeland H., 1984, J AUTISM DEV DISORD, V24, P99
   VANENGELAND H, 1991, PSYCHIAT RES, V38, P27, DOI 10.1016/0165-1781(91)90050-Y
   Watson LR, 2011, J SPEECH LANG HEAR R, V54, P1562, DOI 10.1044/1092-4388(2011/10-0029)
   Woodard CR, 2012, RES AUTISM SPECT DIS, V6, P1234, DOI 10.1016/j.rasd.2012.03.012
NR 53
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 468
EP 480
DI 10.1002/aur.1382
PG 13
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300006
PM 24788961
ER

PT J
AU Cook, R
   Brewer, R
   Shah, P
   Bird, G
AF Cook, Richard
   Brewer, Rebecca
   Shah, Punit
   Bird, Geoffrey
TI Intact Facial Adaptation in Autistic Adults
SO AUTISM RESEARCH
LA English
DT Article
DE autism; adaptation; aftereffects; facial identity; facial expressions
ID FACE RECOGNITION; SPECTRUM DISORDERS; CHILDREN; IDENTITY; EMOTION;
   ALEXITHYMIA; EXPRESSIONS; PERCEPTION; FEATURES; 1ST
AB Adaptation paradigms seek to bias subsequently viewed stimuli through prolonged exposure to an adapting stimulus, thereby giving rise to an aftereffect. Recent experiments have found that children with autism spectrum disorders (ASD) show reduced facial aftereffects, prompting some researchers to speculate that all individuals with ASD exhibit deficient facial adaptation. However, caution is required when generalizing findings from samples of children with ASD to the wider ASD population. The reduced facial aftereffects seen in child samples may instead reflect delayed or atypical developmental trajectories, whereby individuals with ASD are slower to develop adaptive mechanisms. In the present study, two experiments were conducted to determine whether high-functioning adults with ASD also show diminished aftereffects for facial identity and expression. In Experiment 1, using a procedure that minimized the contribution of low-level retinotopic adaptation, we observed substantial aftereffects comparable to those seen in matched controls, for both facial identity and expression. A similar pattern of results was seen in Experiment 2 using a revised procedure that increased the contribution of retinotopic adaptation to the facial aftereffects observed. That adults with autism can show robust facial aftereffects raises the possibility that group differences are seen only at particular points during development, and may not be a lifelong feature of the condition. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Cook, Richard] City Univ London, Dept Psychol, London EC1R OJD, England.
   [Brewer, Rebecca; Shah, Punit; Bird, Geoffrey] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
   [Shah, Punit] Univ London, Birkbeck Coll, Dept Psychol Sci, London, England.
   [Bird, Geoffrey] UCL, Inst Cognit Neurosci, London, England.
RP Cook, R (reprint author), City Univ London, Dept Psychol, Whiskin St, London EC1R OJD, England.
EM Richard.Cook.1@city.ac.uk
CR Afraz SR, 2008, VISION RES, V48, P42, DOI 10.1016/j.visres.2007.10.028
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   BLAKEMOR.C, 1969, J PHYSIOL-LONDON, V203, P237
   Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
   CAMPBELL R, 1995, J EXP CHILD PSYCHOL, V59, P196, DOI 10.1006/jecp.1995.1009
   CAREY S, 1977, SCIENCE, V195, P312, DOI 10.1126/science.831281
   CAREY S, 1980, DEV PSYCHOL, V16, P257, DOI 10.1037/0012-1649.16.4.257
   Clifford C. W. G., 2005, FITTING MIND WORLD A
   Cook R., 2011, J VISION, V11, P1, DOI DOI 10.1167/11.4.2
   Cook R, 2013, PSYCHOL SCI, V24, P723, DOI 10.1177/0956797612463582
   Bird G, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.61
   Dennett HW, 2012, PSYCHOL SCI, V23, P1279, DOI 10.1177/0956797612446350
   Ekman P., 1976, PICTURES FACIAL AFFE
   Ewing L, 2013, DEVELOPMENTAL SCI, V16, P116, DOI 10.1111/desc.12007
   Fiorentini C, 2012, NEUROPSYCHOLOGIA, V50, P2926, DOI 10.1016/j.neuropsychologia.2012.08.019
   Germine LT, 2011, COGNITION, V118, P201, DOI 10.1016/j.cognition.2010.11.002
   Golarai G, 2007, NAT NEUROSCI, V10, P512, DOI 10.1038/nn1865
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Johnston PJ, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00026
   Johnston PJ, 2011, FRONT PSYCHOL, V2, P1, DOI DOI 10.3389/FPSYG.2011.00026
   Kadosh KC, 2013, NEUROIMAGE, V69, P11, DOI 10.1016/j.neuroimage.2012.11.060
   Kingdom F. A. A., 2009, PALAMEDES MATLAB ROU
   Leopold DA, 2001, NAT NEUROSCI, V4, P89, DOI 10.1038/82947
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
   Mondloch CJ, 2006, CHILD DEV, V77, P234, DOI 10.1111/j.1467-8624.2006.00867.x
   Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339
   MOVSHON JA, 1979, NATURE, V278, P850, DOI 10.1038/278850a0
   OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
   Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366
   Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009
   Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065
   Rhodes G, 2006, VISION RES, V46, P2977, DOI 10.1016/j.visres.2006.03.002
   Rhodes G, 2013, NEUROPSYCHOLOGIA, V51, P2702, DOI [10.1016/j.neuropsychologia.2013.08.016, 10.1016/Lneuropsychologia.2013.08.016]
   Rhodes G, 2010, VISION RES, V50, P963, DOI 10.1016/j.visres.2010.03.003
   Rhodes G, 2007, VISION RES, V47, P2291, DOI 10.1016/j.visres.2007.05.012
   Rutherford M., 2011, J AUTISM DEV DISORD, V42, P221
   Rutherford MD, 2008, J EXP PSYCHOL HUMAN, V34, P27, DOI 10.1037/0096-1523.34.1.27
   Scherf KS, 2007, DEVELOPMENTAL SCI, V10, pF15, DOI 10.1111/j.1467-7687.2007.00595.x
   Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Skinner AL, 2010, PSYCHOL SCI, V21, P1248, DOI 10.1177/0956797610380702
   Susilo T, 2010, VISION RES, V50, P300, DOI 10.1016/j.visres.2009.11.016
   Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
   VALENTINE T, 1991, Q J EXP PSYCHOL-A, V43, P161
   Webster MA, 2011, PHILOS T R SOC B, V366, P1702, DOI 10.1098/rstb.2010.0360
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
NR 48
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 481
EP 490
DI 10.1002/aur.1381
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300007
PM 24757172
ER

PT J
AU Hauth, I
   de Bruijn, YGE
   Staal, W
   Buitelaar, JK
   Rommelse, NN
AF Hauth, Ingeborg
   de Bruijn, Yvette G. E.
   Staal, Wouter
   Buitelaar, Jan K.
   Rommelse, Nanda N.
TI Testing the Extreme Male Brain Theory of Autism Spectrum Disorder in a
   Familial Design
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; extreme male brain theory; testosterone;
   2D:4D; finger length; siblings; parents; empathizing; systemizing
ID 4TH DIGIT LENGTH; FETAL TESTOSTERONE; SEX-DIFFERENCES; DIAGNOSTIC
   VALIDITY; RECEPTOR GENE; RATIO; CHILDREN; 2ND; TRAITS; HORMONE
AB Autism Spectrum Disorder (ASD) may be an extreme manifestation of some male-typical traits in both neuroanatomy and cognition. Using the ratio of the second to fourth digit (2D:4D) and digit length as biomarkers of (pre- and postnatal) testosterone levels, examined was whether hypermasculinized digit ratios and/or lengths were familial traits in ASD and investigated their relation to sexually dimorphic cognitive abilities. 2D: 4D ratios and digit lengths of 216 children with ASD, 202 unaffected siblings, and 360 parents were compared with those of 174 control children and their 146 parents. Generalized Estimation Equations, Generalized Linear Models, and Linear Mixed Models were used to investigate parent-offspring relationships and group differences. In ASD probands and their relatives alike, digit length relative to overall height was significantly increased in comparison to controls. No significant group differences were found between affected and unaffected subjects, or between males and females. Additionally, 2D: 4D ratios increased with age. No (consistent) associations were found between 2D: 4D ratio or digit lengths and systemizing and empathizing skills. The findings emphasize the role of familially based elevated pre- and postnatal testosterone levels in the liability for ASD, but challenge the use of 2D: 4D ratio as a proxy of prenatal testosterone exposure solely. Given that many genes influence digit length, the exact mechanisms underlying a familial predisposition toward increased digit length in ASD are as yet unknown and needs to be explored in future studies. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Hauth, Ingeborg; Staal, Wouter; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain, Cognit & Behav Dept Cognit Neurosci, NL-6525 GC Nijmegen, Netherlands.
   [de Bruijn, Yvette G. E.; Staal, Wouter; Buitelaar, Jan K.; Rommelse, Nanda N.] Child & Adolescent Psychiat Univ Ctr, Karakter, Nijmegen, Netherlands.
   [Rommelse, Nanda N.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain, Cognit & Behav Dept Psychiat, NL-6525 GC Nijmegen, Netherlands.
RP Rommelse, NN (reprint author), Radboud Univ Nijmegen, Med Ctr, Reinier Postlaan 12, NL-6525 GC Nijmegen, Netherlands.
EM n.lambregts-rommelse@psy.umcn.nl
CR Allaway HC, 2009, AM J HUM BIOL, V21, P365, DOI 10.1002/ajhb.20892
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Auyeung B, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-17
   Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11
   Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
   Bejerot S, 2012, BRIT J PSYCHIAT, V201, P116, DOI 10.1192/bjp.bp.111.097899
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Brown WM, 2002, HORM BEHAV, V42, P380, DOI 10.1006/hbeh.2002.1830
   Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
   Cherney ID, 2010, PERCEPT MOTOR SKILL, V110, P809, DOI 10.2466/PMS.110.3.809-824
   COLLAER ML, 1995, PSYCHOL BULL, V118, P55, DOI 10.1037//0033-2909.118.1.55
   De Sonneville L. M. J., 2005, TIJDSCHRIFT NEUROPSY, P27
   De Sonneville LMJ, 2002, J CLIN EXP NEUROPSYC, V24, P200, DOI 10.1076/jcen.24.2.200.989
   Forstmeier W, 2010, P ROY SOC B-BIOL SCI, V277, P3353, DOI 10.1098/rspb.2010.1007
   Geary D., 2002, SEXUAL SELECTION SEX
   Geier DA, 2007, NEUROENDOCRINOL LETT, V28, P565
   Goodman JDT, 1997, J BIOSOC SCI, V29, P181, DOI 10.1017/S0021932097001818
   Honekopp J, 2007, PSYCHONEUROENDOCRINO, V32, P313, DOI 10.1016/j.psyneuen.2007.01.007
   Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
   Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Lippa RA, 2006, BIOL PSYCHOL, V71, P116, DOI 10.1016/j.biopsycho.2005.02.004
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Lutchmaya S, 2004, EARLY HUM DEV, V77, P23, DOI 10.1016/j.earlhumdev.2003.12.002
   Lutchmaya S, 2002, INFANT BEHAV DEV, V24, P418
   Manning JT, 2002, DIGIT RATIO POINTER
   Manning JT, 2003, EVOL HUM BEHAV, V24, P399, DOI 10.1016/S1090-5138(03)00052-7
   Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317
   Manning JT, 1998, HUM REPROD, V13, P3000, DOI 10.1093/humrep/13.11.3000
   McIntyre MH, 2006, AM J PHYS ANTHROPOL, V129, P143, DOI 10.1002/ajpa.20240
   McIntyre MH, 2005, P ROY SOC B-BIOL SCI, V272, P1473, DOI 10.1098/rspd.2005.3100
   Milne E, 2006, J AUTISM DEV DISORD, V36, P225, DOI 10.1007/s10803-005-0052-3
   Noipayak Pongsak, 2009, Journal of the Medical Association of Thailand, V92, P1040
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   Teatero ML, 2013, J AUTISM DEV DISORD, V43, P2664, DOI 10.1007/s10803-013-1819-6
   Tordjman S, 1997, AM J PSYCHIAT, V154, P1626
   Ventura T, 2013, EARLY HUM DEV, V89, P107, DOI 10.1016/j.earlhumdev.2012.08.009
   Wallen K, 2009, ENDOCRINOLOGY, V150, P4819, DOI 10.1210/en.2009-0986
   Wechsler D., 1989, WECHSLER PRESCHOOL P
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 44
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 491
EP 500
DI 10.1002/aur.1384
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300008
PM 24777834
ER

PT J
AU Kang, V
   Wagner, GC
   Ming, X
AF Kang, Victor
   Wagner, George C.
   Ming, Xue
TI Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorders; gastrointestinal disorders; comorbid
   disorders; endoscopy; colonoscopy; inflammation
ID SYMPTOMS; ABNORMALITIES; POPULATION; PREVALENCE; DISEASE; ASDS
AB Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Kang, Victor] Johns Hopkin Univ, Sch Arts & Sci, Baltimore, MD USA.
   [Wagner, George C.] Rutgers State Univ, Dept Psychol, New Brunswick, NJ 08903 USA.
   [Ming, Xue] Rutgers State Univ, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA.
   [Ming, Xue] JFK Med Ctr, New Jersey Neurosci Inst, Sleep Med Ctr, Edison, NJ USA.
RP Ming, X (reprint author), Rutgers State Univ, New Jersey Med Sch, 90 Bergen St,DOC 8100, Newark, NJ 07103 USA.
EM mingxu@njms.rutgers.edu
FU Knights of Columbus, East Hanover, NJ
FX The authors wish to acknowledge the cooperation of all the parents and
   guardians of the participating subjects with ASD and the generous
   support from Knights of Columbus, East Hanover, NJ. All authors declare
   no conflict of interest in this study and approve this final version of
   the revised manuscript.
CR Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419
   Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
   Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D
   Coury Daniel L, 2012, Pediatrics, V130 Suppl 2, pS160, DOI 10.1542/peds.2012-0900N
   Harris C, 2012, COMPLEMENT THER MED, V20, P437, DOI 10.1016/j.ctim.2012.08.004
   Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1
   Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
   Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
   Jyonouchi H, 2011, J NEUROIMMUNOL, V238, P73, DOI 10.1016/j.jneuroim.2011.07.001
   Ming X, 2012, J PROTEOME RES, V11, P5856, DOI 10.1021/pr300910n
   Molloy CA, 2003, AUTISM, V7, P165, DOI 10.1177/1362361303007002004
   Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8
   Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0
   Reichelt KL, 2009, ANN CLIN PSYCHIATRY, V21, P205
   Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418
   Taylor B, 2002, BRIT MED J, V324, P393, DOI 10.1136/bmj.324.7334.393
   Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
   Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a
   Xue Ming, 2008, J Child Neurol, V23, P6
NR 19
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2014
VL 7
IS 4
BP 501
EP 506
DI 10.1002/aur.1386
PG 6
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA AN5VJ
UT WOS:000340659300009
PM 24753336
ER

PT J
AU Blockus, H
   Chedotal, A
AF Blockus, Heike
   Chedotal, Alain
TI The multifaceted roles of Slits and Robos in cortical circuits: from
   proliferation to axon guidance and neurological diseases
SO CURRENT OPINION IN NEUROBIOLOGY
LA English
DT Article
ID F-BAR DOMAIN; NEURONAL MIGRATION; INTERNEURON MIGRATION; THALAMIC
   PROJECTIONS; MAMMALIAN FOREBRAIN; CORPUS-CALLOSUM; CEREBRAL-CORTEX;
   MIDLINE; EXPRESSION; RECEPTORS
AB Slit repulsion, mediated by Robe receptors, is known to play a major role in axon guidance in the nervous system. However, recent studies have revealed that in the mammalian cortex these molecules are highly versatile and that their function extends far beyond axon guidance. They act at all phases of development to control neurogenesis, neuronal migration, axon patterning, dendritic outgrowth and spinogenesis. The expression of Robe receptors in cortical and thalamocortical axons (TCAs) is tightly regulated by a combination of transcription factors (TFs), proteases and activity. These findings also suggest that Slit and Robes have influenced the evolution of cortical circuits. Last, novel genetic evidence associates various neurological disorders, such as autism, to abnormal Slit/Robo signaling.
C1 [Blockus, Heike; Chedotal, Alain] INSERM, UMR S968, Inst Vis, F-75012 Paris, France.
   [Blockus, Heike; Chedotal, Alain] Univ Paris 06, Sorbonne Univ, UMR S968, Inst Vis, F-75012 Paris, France.
   [Blockus, Heike; Chedotal, Alain] CNRS, UMR7210, F-75012 Paris, France.
RP Chedotal, A (reprint author), INSERM, UMR S968, Inst Vis, F-75012 Paris, France.
EM alain.chedotal@inserm.fr
FU Fondation pour la recherche Medicale (Programme equipe FRM); Labex
   Lifesciences; Ecole des Neurosciences de Paris Ile-de-France (ENP); DIM
   Cerveau Pensee
FX A.C. is supported by grants from the Fondation pour la recherche
   Medicale (Programme equipe FRM) and the Labex Lifesciences. H.B. is a
   recipient of the ENP Graduate Program fellowship from Ecole des
   Neurosciences de Paris Ile-de-France (ENP) and DIM Cerveau & Pensee.
CR Amaniti EM, 2013, DEV BIOL, V376, P113, DOI 10.1016/j.ydbio.2013.02.001
   Andrews W, 2006, DEVELOPMENT, V133, P2243, DOI 10.1242/dev.02379
   Andrews W, 2008, DEV BIOL, V313, P648, DOI 10.1016/j.ydbio.2007.10.052
   Anitha A, 2008, AM J MED GENET B, V147B, P1019, DOI 10.1002/ajmg.b.30697
   Bagri A, 2002, NEURON, V33, P233, DOI 10.1016/S0896-6273(02)00561-5
   Bai G, 2011, CELL, V144, P106, DOI 10.1016/j.cell.2010.11.053
   BARBER M, 2009, CEREB CORTEX S1, V19, P22
   Bielle F, 2011, CURR BIOL, V21, P1748, DOI 10.1016/j.cub.2011.09.008
   Bielle F, 2011, NEURON, V69, P1085, DOI 10.1016/j.neuron.2011.02.026
   Bormuth I, 2013, J NEUROSCI, V33, P641, DOI 10.1523/JNEUROSCI.0899-12.2013
   Borrell V, 2012, NEURON, V76, P338, DOI 10.1016/j.neuron.2012.08.003
   Carlson BR, 2011, J NEUROSCI, V31, P2447, DOI 10.1523/JNEUROSCI.4433-10.2011
   Charrier C, 2012, CELL, V149, P923, DOI 10.1016/j.cell.2012.03.034
   Chatterjee M, 2012, DEVELOPMENT, V139, P4633, DOI 10.1242/dev.086991
   Conway CD, 2011, J NEUROSCI, V31, P1955, DOI 10.1523/JNEUROSCI.2579-10.2011
   Coutinho-Budd J, 2012, J CELL SCI, V125, P3390, DOI 10.1242/jcs.098962
   Deck M, 2013, NEURON, V77, P472, DOI 10.1016/j.neuron.2012.11.031
   Dennis MY, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.033
   Endris V, 2002, P NATL ACAD SCI USA, V99, P11754, DOI 10.1073/pnas.162241099
   Fan XP, 2003, NEURON, V40, P113, DOI 10.1016/S0896-6273(03)00591-9
   Gibson DA, 2014, NEURON, V81, P1040, DOI 10.1016/j.neuron.2014.01.009
   Gonda Y, 2013, CEREB CORTEX, V23, P1495, DOI 10.1093/cercor/bhs141
   Guerrier S, 2009, CELL, V138, P990, DOI 10.1016/j.cell.2009.06.047
   Hannula-Jouppi K, 2005, PLOS GENET, V1, P467, DOI 10.1371/journal.pgen.0010050
   Hernandez-Miranda LR, 2011, J NEUROSCI, V31, P6174, DOI 10.1523/JNEUROSCI.5464-10.2011
   Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
   James G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074115
   Khusial PR, 2010, ONCOTARGET, V1, P198
   Lamminmaki S, 2012, J NEUROSCI, V32, P966, DOI 10.1523/JNEUROSCI.4007-11.2012
   Leyva-Diaz E, 2014, CURR BIOL, V24, P494, DOI 10.1016/j.cub.2014.01.042
   Lopez-Bendito G, 2007, J NEUROSCI, V27, P3395, DOI 10.1523/JNEUROSCI.4605-06.2007
   Lopez-Bendito G, 2006, CELL, V125, P127, DOI 10.1016/j.cell.2006.01.042
   LP BK, 2011, CEREB CORTEX, V21, P1395
   Ma L, 2007, J NEUROSCI, V27, P6843, DOI 10.1523/JNEUROSCI.1479-07.2007
   MANN O, 2001, SCIENCE, V293, P872
   Marcos-Mondejar P, 2012, J NEUROSCI, V32, P4372, DOI 10.1523/JNEUROSCI.5851-11.2012
   Marin O, 2003, DEVELOPMENT, V130, P1889, DOI 10.1242/dev.00417
   Mire E, 2012, NAT NEUROSCI, V15, P1134, DOI 10.1038/nn.3160
   Round JE, 2011, MOL CELL NEUROSCI, V47, P265, DOI 10.1016/j.mcn.2011.04.009
   Sasaki T, 2010, CEREB CORTEX, V20, P2496, DOI 10.1093/cercor/bhp319
   Stein E, 2001, SCIENCE, V291, P1928, DOI 10.1126/science.1058445
   Suda S, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-14
   Unni DK, 2012, DEV BIOL, V365, P36, DOI 10.1016/j.ydbio.2012.02.004
   Wang KH, 1999, CELL, V96, P771, DOI 10.1016/S0092-8674(00)80588-7
   Whitford KL, 2002, NEURON, V33, P47, DOI 10.1016/S0896-6273(01)00566-9
   Wong K, 2001, CELL, V107, P209, DOI 10.1016/S0092-8674(01)00530-X
   Ypsilanti AR, 2010, DEVELOPMENT, V137, P1939, DOI 10.1242/dev.044511
NR 47
TC 5
Z9 5
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-4388
EI 1873-6882
J9 CURR OPIN NEUROBIOL
JI Curr. Opin. Neurobiol.
PD AUG
PY 2014
VL 27
BP 82
EP 88
DI 10.1016/j.conb.2014.03.003
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA AO3HN
UT WOS:000341220400013
PM 24698714
ER

PT J
AU Ackerman, S
   Wenegrat, J
   Rettew, D
   Althoff, R
   Bernier, R
AF Ackerman, Sean
   Wenegrat, Julia
   Rettew, David
   Althoff, Robert
   Bernier, Raphael
TI No increase in autism-associated genetic events in children conceived by
   assisted reproduction
SO FERTILITY AND STERILITY
LA English
DT Article
DE Assisted reproduction; assisted reproductive technology; autism; copy
   number variation
ID IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM INJECTION;
   LOW-BIRTH-WEIGHT; SPECTRUM DISORDERS; INCREASED RISK; HEALTH OUTCOMES;
   PRETERM BIRTH; FOLLOW-UP; TECHNOLOGY; BORN
AB Objective: To understand the rate of genetic events in patients with autism spectrum disorder (ASD) who were exposed to assisted reproduction.
   Design: Case control study using genetics data.
   Setting: Twelve collaborating data collection sites across North America as part of the Simons Simplex Collection.
   Patient(s): 2,760 children with ASD, for whom 1,994 had published copy number variation data and 424 had published gene mutation status available.
   Intervention(s): None.
   Main Outcome Measure(s): Rates of autism-associated genetic events in children with ASD conceived with assisted reproduction versus those conceived naturally.
   Result(s): No statistically significant differences in copy number variations or autism-associated gene-disrupting events were found when comparing ASD patients exposed to assisted reproduction with those not exposed to assisted reproduction.
   Conclusion(s): This is the first large genetic association to concurrently examine the genotype of individuals with ASD in relation to their exposure to ART versus natural conception, and it adds reassuring evidence to the argument that ART does not increase the risk of ASD. ((C)2014 by American Society for Reproductive Medicine.)
C1 [Ackerman, Sean; Rettew, David; Althoff, Robert] Univ Vermont, Sch Med, Dept Psychiat, Burlington, VT 05401 USA.
   [Wenegrat, Julia; Bernier, Raphael] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
RP Ackerman, S (reprint author), Univ Vermont, Fletcher Allen Hlth Care, 111 Colchester Ave,MS 341BA1, Burlington, VT 05401 USA.
EM sean.ackerman@vtmednet.org
FU Simons Foundation Autism Research Initiative
FX Funded by the Simons Foundation Autism Research Initiative.
CR Abel KM, 2013, AM J PSYCHIAT, V170, P391, DOI 10.1176/appi.ajp.2012.12040543
   Adamson GD, 2006, FERTIL STERIL, V85, P1586, DOI 10.1016/j.fertnstert.2006.01.011
   Agarwal P, 2005, BJOG-INT J OBSTET GY, V112, P1376, DOI 10.1111/j.1471-0528.2005.00663.x
   Allen Victoria M, 2006, J Obstet Gynaecol Can, V28, P220
   [Anonymous], 2013, DIAGNOSTIC STAT MANU, V5th
   Association AP, 2000, DIAGN STAT MAN MENT
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Barnes J, 2004, HUM REPROD, V19, P1480, DOI 10.1093/humrep/deh239
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Blumberg SJ, 2013, NATL CTR HLTH STAT, V2013, P65
   Centers for Disease Control and Prevention, WHAT IS ASS REPR TEC
   Conti E, 2013, HUM REPROD, V28, P3316, DOI 10.1093/humrep/det380
   Conway DA, 2011, FERTIL STERIL, V95, P503, DOI 10.1016/j.fertnstert.2010.09.019
   Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
   Flashner BM, 2013, NEUROMOL MED, V15, P339, DOI 10.1007/s12017-013-8222-5
   Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
   Hvidtjorn D, 2009, ARCH PEDIAT ADOL MED, V163, P72, DOI 10.1001/archpediatrics.2008.507
   Hvidtjorn D, 2011, J EPIDEMIOL COMMUN H, V65, P497, DOI 10.1136/jech.2009.093823
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
   Lehti V, 2013, HUM REPROD, V28, P812, DOI 10.1093/humrep/des430
   Leunens L, 2008, HUM REPROD, V23, P105, DOI 10.1093/humrep/dem257
   Lyall K, 2012, PAEDIATR PERINAT EP, V26, P361, DOI 10.1111/j.1365-3016.2012.01294.x
   Mains L, 2010, HUM REPROD, V25, P2605, DOI 10.1093/humrep/deq218
   McGovern PG, 2004, FERTIL STERIL, V82, P1514, DOI 10.1016/j.fertnstert.2004.06.038
   Melnyk S, 2012, J AUTISM DEV DISORD, V42, P367, DOI 10.1007/s10803-011-1260-7
   Millan MJ, 2013, NEUROPHARMACOLOGY, V68, P2, DOI 10.1016/j.neuropharm.2012.11.015
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   Papaligoura Z, 2004, HUM REPROD, V19, P1488, DOI 10.1093/humrep/deh270
   Ponjaert-Kristoffersen I, 2005, PEDIATRICS, V115, pE283, DOI 10.1542/peds.2004-1445
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sandin S, 2013, JAMA-J AM MED ASSOC, V310, P75, DOI 10.1001/jama.2013.7222
   Schieve LA, 2004, OBSTET GYNECOL, V103, P1154, DOI 10.1097/01.AOG.0000124571.04890.67
   Schieve LA, 2002, NEW ENGL J MED, V346, P731, DOI 10.1056/NEJMoa010806
   Shevell T, 2005, OBSTET GYNECOL, V106, P1039, DOI 10.1097/01.AOG.0000183593.24583.7c
   Sutcliffe AG, 2003, FERTIL STERIL, V79, P512, DOI 10.1016/S0015-0282(02)04701-5
   Sutcliffe AG, 2001, LANCET, V357, P2080, DOI 10.1016/S0140-6736(00)05180-1
   Vermeiden JPW, 2013, FERTIL STERIL, V99, P642, DOI 10.1016/j.fertnstert.2013.01.125
   Wang YA, 2005, FERTIL STERIL, V83, P1650, DOI 10.1016/j.fertnstert.2004.12.033
   Wen J, 2012, FERTIL STERIL, V97
   Wilson CL, 2011, HUM REPROD, V26, P1209, DOI 10.1093/humrep/der041
   Zachor DA, 2011, RES DEV DISABIL, V32, P2950, DOI 10.1016/j.ridd.2011.05.007
NR 44
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD AUG
PY 2014
VL 102
IS 2
BP 388
EP 393
DI 10.1016/j.fertnstert.2014.04.020
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA AO4HX
UT WOS:000341299000015
PM 24842673
ER

PT J
AU Batey, CA
   Missiuna, CA
   Timmons, BW
   Hay, JA
   Faught, BE
   Cairney, J
AF Batey, C. A.
   Missiuna, C. A.
   Timmons, B. W.
   Hay, J. A.
   Faught, B. E.
   Cairney, J.
TI Self-efficacy toward physical activity and the physical activity
   behavior of children with and without Developmental Coordination
   Disorder
SO HUMAN MOVEMENT SCIENCE
LA English
DT Article
DE Developmental Coordination Disorder; Self-efficacy; Physical activity;
   Developmental disorders and autism
ID DEFICIT HYPERACTIVITY DISORDER; ACTIVITY ENERGY-EXPENDITURE; MOVEMENT
   ASSESSMENT BATTERY; ADOLESCENTS; MOTOR; RISK; PERCEPTIONS; HYPOTHESIS;
   CLUMSINESS; FITNESS
AB Purpose: Affecting 5-6% of children, Developmental Coordination Disorder (DCD) is a prevalent chronic condition. The nature of the disorder - impaired motor coordination - makes avoidance of physical activity (PA) common. The purpose of this study was to examine the effect of barrier and task self-efficacy on PA behavior in children with DCD and a group of typically developing (TD) children.
   Methods: Children were compared on their perceived ability to complete different intensities and duration of PA (task efficacy) and their confidence in completing PA when faced with everyday barriers (barrier efficacy). An accelerometer was used to record their activity over the subsequent week.
   Results: Children with DCD were found to have significantly lower task efficacy and barrier efficacy. They also spent significantly less time in moderate to vigorous physical activity (MVPA). Multivariate analyses revealed that gender modified the relationship for both groups. Separate multivariate regressions, were therefore conducted by gender. A direct effect of DCD on PA was observed for boys, but not for girls. Further analyses showed that neither task efficacy nor barrier efficacy influenced the relationship between DCD and PA.
   Conclusion: Results from this study confirm that children with DCD have lower task and barrier self-efficacy than TD children and that males have lower PA levels than their TD peers; however neither task or barrier self-efficacy mediated the relationship between DCD and PA. (C) 2013 Published by Elsevier B.V.
C1 [Batey, C. A.; Missiuna, C. A.; Timmons, B. W.; Cairney, J.] McMaster Univ, Fac Hlth Sci, Hamilton, ON L8S 4K1, Canada.
   [Hay, J. A.; Faught, B. E.] Brock Univ, Fac Appl Hlth Sci, St Catharines, ON L2S 3A1, Canada.
RP Cairney, J (reprint author), Dept Family Med, 175 Longwood Rd South, Hamilton, ON L8P 0A1, Canada.
EM cairnej@mcmaster.ca
FU Canadian Institutes of Health Research [66959]; Department of Family
   Medicine at McMaster University
FX This study was supported by the Canadian Institutes of Health Research
   (Grant #: 66959). Dr. Cairney is supported through an endowed
   professorship in the Department of Family Medicine at McMaster
   University. The Physical Health Activity Study Team (PHAST) appreciates
   the commitment by children, parents and teachers from the District
   School Board of Niagara. Laboratory and home-based assessment would not
   have been successful without the diligent efforts of the PHAST research
   coordinator, Nadilein Mahlberg. Finally, thanks to Joyce Obeid for all
   of her hard work and help with analyzing the accelerometer data.
CR Actical Instruction Manual, 2006, ACT VERS 2 0
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Armstrong N, 2006, SPORTS MED, V36, P1067, DOI 10.2165/00007256-200636120-00005
   Baerg S, 2011, RES DEV DISABIL, V32, P1343, DOI 10.1016/j.ridd.2011.02.009
   Bandura A, 2004, HEALTH EDUC BEHAV, V31, P143, DOI 10.1177/1090198104263660
   Baxter-Jones ADG, 2005, PEDIATR EXERC SCI, V17, P18
   Bouffard M, 1996, ADAPT PHYS ACT Q, V13, P61
   Brodersen NH, 2007, BRIT J SPORT MED, V41, P140, DOI 10.1136/bjsm.2006.031138
   Brown T, 2009, PHYS OCCUP THER PEDI, V29, P86, DOI 10.1080/01942630802574908
   Cairney John, 2005, J Pediatr, V147, P515, DOI 10.1016/j.jpeds.2005.05.013
   Cairney J, 2010, RES DEV DISABIL, V31, P1332, DOI 10.1016/j.ridd.2010.07.008
   Cairney J., 2009, DEV MED CHILD NEUROL, V52, pe67
   Cairney J, 2005, ADAPT PHYS ACT Q, V22, P67
   Cairney J, 2005, INT J OBESITY, V29, P369, DOI 10.1038/sj.ijo.0802893
   Cairney J, 2007, PEDIATR EXERC SCI, V19, P20
   Cairney J, 2006, ADAPT PHYS ACT Q, V23, P261
   CANTELL MH, 1994, ADAPT PHYS ACT Q, V11, P115
   Colley R. C., 2011, HLTH REP, V22, P1
   Croce RV, 2001, PERCEPT MOTOR SKILL, V93, P275
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   Faught BE, 2005, J ADOLESCENT HEALTH, V37, P376, DOI 10.1016/j.jadohealth.2004.09.021
   Fitzpatrick DA, 2003, ADAPT PHYS ACT Q, V20, P279
   Foley L, 2008, PEDIATR EXERC SCI, V20, P342
   Green D, 2011, RES DEV DISABIL, V32, P1332, DOI 10.1016/j.ridd.2011.01.040
   Harter S., 1982, CHILD DEV, V53, P81
   Hay J., 1992, CLIN J SPORT MED, V2, P92
   Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
   Janssen I, 2006, AM J CLIN NUTR, V83, P139
   Kadesjo B, 1999, J AM ACAD CHILD PSY, V38, P820, DOI 10.1097/00004583-199907000-00011
   Kaufman A. S., 2004, KAUFMAN BRIEF INTELL
   Kimm SYS, 2002, NEW ENGL J MED, V347, P709, DOI 10.1056/NEJMoa003277
   LOSSE A, 1991, DEV MED CHILD NEUROL, V33, P55
   Maddux J. E., 1995, SELF EFFICACY ADAPTA, P377, DOI 10.1007/978-1-4419-6868-5_14
   McAuley E, 1998, ADV SPORT EXERCISE P, P371
   Mirwald RL, 2002, MED SCI SPORT EXER, V34, P689, DOI 10.1097/00005768-200204000-00020
   Piek J., 2000, DEV MED CHILD NEUROL, V37, P976
   Piek JP, 2006, HUM MOVEMENT SCI, V25, P65, DOI 10.1016/j.humov.2005.10.011
   Pitcher TM, 2002, HUM MOVEMENT SCI, V21, P919, DOI 10.1016/S0167-9457(02)00167-7
   Poulsen AA, 2008, OTJR-OCCUP PART HEAL, V28, P30, DOI 10.3928/15394492-20080101-05
   Puyau MR, 2004, MED SCI SPORT EXER, V36, P1625, DOI 10.1249/01.MSS.0000139898.30804.60
   Rose B, 1997, ADAPT PHYS ACT Q, V14, P210
   Schott N, 2007, RES Q EXERCISE SPORT, V78, P438
   Shoemaker M. M., 1994, ADAPT PHYS ACT Q, V11, P130
   Skinner RA, 2001, HUM MOVEMENT SCI, V20, P73, DOI 10.1016/S0167-9457(01)00029-X
   Sugden D., 2006, ESCR RES SEMINAR SER, P1
   Tremblay MS, 2011, APPL PHYSIOL NUTR ME, V36, P36, DOI 10.1139/H11-009
   Welk GJ, 2000, RES Q EXERCISE SPORT, V71, pS59
   Wrotniak BH, 2006, PEDIATRICS, V118, pE1758, DOI 10.1542/peds.2006-0742
NR 48
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-9457
EI 1872-7646
J9 HUM MOVEMENT SCI
JI Hum. Mov. Sci.
PD AUG
PY 2014
VL 36
BP 258
EP 271
DI 10.1016/j.humov.2013.10.003
PG 14
WC Neurosciences; Psychology; Psychology, Experimental; Sport Sciences
SC Neurosciences & Neurology; Psychology; Sport Sciences
GA AO4XW
UT WOS:000341345700021
PM 24345354
ER

PT J
AU Rahbar, MH
   Samms-Vaughan, M
   Ma, JZ
   Bressler, J
   Loveland, KA
   Ardjomand-Hessabi, M
   Dickerson, AS
   Grove, ML
   Shakespeare-Pellington, S
   Beecher, C
   McLaughlin, W
   Boerwinkle, E
AF Rahbar, Mohammad H.
   Samms-Vaughan, Maureen
   Ma, Jianzhong
   Bressler, Jan
   Loveland, Katherine A.
   Ardjomand-Hessabi, Manouchehr
   Dickerson, Aisha S.
   Grove, Megan L.
   Shakespeare-Pellington, Sydonnie
   Beecher, Compton
   McLaughlin, Wayne
   Boerwinkle, Eric
TI Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican
   Children with and without Autism Spectrum Disorder
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE arsenic; autism spectrum disorder (ASD); glutathione S-transferase (GST)
   genes; detoxification; interactions
ID GLUTATHIONE S-TRANSFERASES; OXIDATIVE STRESS; DRINKING-WATER; CHILDHOOD
   AUTISM; DNA METHYLATION; MERCURY LEVELS; SKIN-LESIONS; EXPOSURE;
   POLYMORPHISMS; RISK
AB Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1: 1 age- and sex-matched typically developing (TD) controls (age 2-8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 mu g/L vs. 2.69 mu g/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.
C1 [Rahbar, Mohammad H.; Boerwinkle, Eric] Univ Texas Sch Publ Hlth Houston, Div Epidemiol Human Genet & Environm Sci EHGES, Houston, TX 77030 USA.
   [Rahbar, Mohammad H.; Ma, Jianzhong] Univ Texas Hlth Sci Ctr Houston, Div Clin & Translat Sci, Dept Internal Med, Sch Med, Houston, TX 77030 USA.
   [Rahbar, Mohammad H.; Ardjomand-Hessabi, Manouchehr; Dickerson, Aisha S.] Univ Texas Hlth Sci Ctr Houston, CCTS, Houston, TX 77030 USA.
   [Samms-Vaughan, Maureen; Shakespeare-Pellington, Sydonnie] Univ W Indies, Dept Child & Adolescent Hlth, Kingston 7, Jamaica.
   [Bressler, Jan; Grove, Megan L.; Boerwinkle, Eric] Univ Texas Sch Publ Hlth Houston, Ctr Human Genet, Houston, TX 77030 USA.
   [Loveland, Katherine A.] Univ Texas Med Sch Houston, Dept Psychiat & Behav Sci, Houston, TX 77054 USA.
   [Beecher, Compton; McLaughlin, Wayne] Univ W Indies, Dept Basic Med Sci, Kingston 7, Jamaica.
   [McLaughlin, Wayne] Univ W Indies, Caribbean Genet CARIGEN, Kingston 7, Jamaica.
RP Rahbar, MH (reprint author), Univ Texas Sch Publ Hlth Houston, Div Epidemiol Human Genet & Environm Sci EHGES, Houston, TX 77030 USA.
EM Mohammad.H.Rahbar@uth.tmc.edu; msammsvaughan@gmail.com;
   Jianzhong.Ma@uth.tmc.edu; Jan.Bressler@uth.tmc.edu;
   Katherine.A.Loveland@uth.tmc.edu; Manouchehr.A.Hessabi@uth.tmc.edu;
   Aisha.S.Dickerson@uth.tmc.edu; Megan.L.Grove@uth.tmc.edu;
   sydonniesp@gmail.com; compton.beecher@uwimona.edu.jm;
   wayne.mclaughlin@uwimona.edu.jm; Eric.Boerwinkle@uth.tmc.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD); National Institutes of Health Fogarty International
   Center (NIH-FIC) [R21HD057808]; National Institute of Environmental
   Health Sciences (NIEHS) [R01ES022165];
   Biostatistics/Epidemiology/Research Design (BERD) component of the
   Center for Clinical and Translational Sciences (CCTS); NIH Centers for
   Translational Science Award (NIH CTSA) [UL1 RR024148]; National Center
   for Research Resources (NCRR) [UL1 TR000371]; National Center for
   Advancing Translational Sciences (NCATS)
FX This research is co-funded by the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (NICHD) and the National
   Institutes of Health Fogarty International Center (NIH-FIC) by a grant
   (R21HD057808) as well as National Institute of Environmental Health
   Sciences (NIEHS) by a grant (R01ES022165) awarded to University of Texas
   Health Science Center at Houston. We also acknowledge the support
   provided by the Biostatistics/Epidemiology/Research Design (BERD)
   component of the Center for Clinical and Translational Sciences (CCTS)
   for this project. CCTS is mainly funded by the NIH Centers for
   Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to
   University of Texas Health Science Center at Houston in 2006 by the
   National Center for Research Resources (NCRR) and its renewal (UL1
   TR000371) by the National Center for Advancing Translational Sciences
   (NCATS). The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the NICHD or the
   NIH-FIC or NIEHS or the NCRR or the NCATS.
CR Abernathy CO, 2003, J NUTR, V133, p1536S
   Adams JB, 2013, BIOL TRACE ELEM RES, V151, P171, DOI 10.1007/s12011-012-9551-1
   Adams JB, 2006, BIOL TRACE ELEM RES, V110, P193, DOI 10.1385/BTER:110:3:193
   Agusa T, 2010, TOXICOL APPL PHARM, V242, P352, DOI 10.1016/j.taap.2009.11.007
   Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P213
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Aposhian HV, 2006, CHEM RES TOXICOL, V19, P1, DOI 10.1021/tx050106d
   ATSDR, 2007, TOX PROF ARS
   Aynacioglu AS, 2004, BRIT J CLIN PHARMACO, V57, P213, DOI 10.1046/j.1365-2125.2003.01975.x
   Blaurock-Busch Eleonor, 2012, Maedica (Buchar), V7, P38
   Blaurock-Busch Eleonor, 2011, Maedica (Buchar), V6, P247
   Borchers A, 2010, CLIN REV ALLERG IMMU, V39, P95, DOI 10.1007/s12016-009-8176-4
   CHALLENGER F, 1945, CHEM REV, V36, P315, DOI 10.1021/cr60115a003
   Chen CL, 1996, PHARMACOGENETICS, V6, P187, DOI 10.1097/00008571-199604000-00005
   Chen YC, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-17
   CULLEN WR, 1989, CHEM REV, V89, P713, DOI 10.1021/cr00094a002
   Dastgiri S, 2010, J HEALTH POPUL NUTR, V28, P14
   Del Razo LM, 2011, ENVIRON HEALTH-GLOB, V10, DOI 10.1186/1476-069X-10-73
   Dols M., 2011, COMPATIBILITY PUREGE
   Fido A, 2005, AUTISM, V9, P290, DOI 10.1177/1362361305053255
   Flora SJS, 1999, CLIN EXP PHARMACOL P, V26, P865, DOI 10.1046/j.1440-1681.1999.03157.x
   Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011
   Grandjean P, 2006, LANCET, V368, P2167, DOI 10.1016/S0140-6736(06)69665-7
   Gribble MO, 2012, AM J EPIDEMIOL, V176, P865, DOI 10.1093/aje/kws153
   Gundacker C, 2007, SCI TOTAL ENVIRON, V385, P37, DOI 10.1016/j.scitotenv.2007.07.033
   Hall M, 2006, TOXICOLOGY, V225, P225, DOI 10.1016/j.tox.2006.06.010
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hayakawa T, 2005, ARCH TOXICOL, V79, P183, DOI 10.1007/s00204-004-0620-x
   Howe A, 2005, ENVIRON GEOCHEM HLTH, V27, P19, DOI 10.1007/s10653-004-5671-7
   Huang WB, 2013, GENE, V526, P80, DOI 10.1016/j.gene.2013.05.032
   Hung RJ, 2004, INT J CANCER, V110, P598, DOI 10.1002/ijc.20157
   IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2004, IARC MONOGRAPHS EVAL, V84
   James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
   Josephy P.D., 2010, HUM GENOMICS PROTEOM, V2010, DOI [10.4061/2010/876940., DOI 10.4061/2010/876940]
   Kern JK, 2007, J TOXICOL ENV HEAL A, V70, P715, DOI 10.1080/15287390601188060
   Kile ML, 2014, EPIGENETICS-US, V9, P774, DOI 10.4161/epi.28153
   Kitchin KT, 2003, TOXICOL LETT, V137, P3, DOI 10.1016/S0378-4274(02)00376-4
   Kitchin KT, 2001, TOXICOL APPL PHARM, V172, P249, DOI 10.1006/taap.2001.9157
   Klautau-Guimaraes MD, 2005, GENET MOL BIOL, V28, P827, DOI 10.1590/S1415-47572005000500027
   Kleinbaum D. G., 2010, LOGISTIC REGRESSION
   Kumagai Y, 2007, ANNU REV PHARMACOL, V47, P243, DOI 10.1146/annurev.pharmtox.47.120505.105144
   Lalor GC, 1996, ENVIRON GEOCHEM HLTH, V18, P89, DOI 10.1007/BF01771284
   Li RL, 2000, ATHEROSCLEROSIS, V149, P451, DOI 10.1016/S0021-9150(99)00483-9
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   McCarty KM, 2007, ENVIRON HEALTH PERSP, V115, P341, DOI 10.1289/ehp.9152
   Melnyk S, 2012, J AUTISM DEV DISORD, V42, P367, DOI 10.1007/s10803-011-1260-7
   Naranmandura H, 2006, CHEM RES TOXICOL, V19, P1010, DOI 10.1021/tx060053f
   Navas-Acien A, 2006, ENVIRON HEALTH PERSP, V114, P641, DOI 10.1289/ehp.8551
   Navas-Acien A, 2008, JAMA-J AM MED ASSOC, V300, P814, DOI 10.1001/jama.300.7.814
   Obrenovich ME, 2011, BIOL TRACE ELEM RES, V144, P475, DOI 10.1007/s12011-011-9146-2
   Pi JB, 2002, ENVIRON HEALTH PERSP, V110, P331
   Pi JB, 2003, FREE RADICAL BIO MED, V35, P102, DOI 10.1016/S0891-5849(03)00269-7
   Rahbar MH, 2013, NEUROTOX RES, V23, P22, DOI 10.1007/s12640-012-9321-z
   Rahbar MH, 2012, SCI TOTAL ENVIRON, V433, P362, DOI 10.1016/j.scitotenv.2012.06.085
   Rahbar MH, 2012, J AUTISM DEV DISORD, V42, P1928, DOI 10.1007/s10803-011-1438-z
   Reichard JF, 2010, EPIGENOMICS-UK, V2, P87, DOI [10.2217/epi.09.45, 10.2217/EPI.09.45]
   Rodrigues EG, 2012, BIOMARKERS, V17, P240, DOI 10.3109/1354750X.2012.658863
   Rossignol DA, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.4
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Seidegard J, 1997, ENVIRON HEALTH PERSP, V105, P791, DOI 10.2307/3433285
   Siniscalco D, 2013, INT J ENV RES PUB HE, V10, P4261, DOI 10.3390/ijerph10094261
   Sohel N, 2009, EPIDEMIOLOGY, V20, P824, DOI 10.1097/EDE.0b013e3181bb56ec
   Stamova B, 2011, NEUROTOX RES, V19, P31, DOI 10.1007/s12640-009-9137-7
   States JC, 2009, TOXICOL SCI, V107, P312, DOI 10.1093/toxsci/kfn236
   Styblo M, 2002, ENVIRON HEALTH PERSP, V110, P767
   Todorova T, 2007, BIOTECHNOL BIOTEC EQ, V21, P348
   Tsai PC, 2006, CHEMOSPHERE, V63, P1410, DOI 10.1016/j.chemosphere.2005.08.012
   Wasserman GA, 2004, ENVIRON HEALTH PERSP, V112, P1329, DOI 10.1289/ehp.6964
   Wei BB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071640
   Westphal GA, 2000, INT ARCH OCC ENV HEA, V73, P384, DOI 10.1007/s004200000159
   WHO, 2001, ENV HLTH CRIT
   Wu F, 2012, AM J EPIDEMIOL, V175, P1252, DOI 10.1093/aje/kwr464
NR 77
TC 3
Z9 3
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2014
VL 11
IS 8
BP 7874
EP 7895
DI 10.3390/ijerph110807874
PG 22
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AO1UX
UT WOS:000341101700021
PM 25101770
ER

PT J
AU Bennett, CC
   Sabanovic, S
AF Bennett, Casey C.
   Sabanovic, Selma
TI Deriving Minimal Features for Human-Like Facial Expressions in Robotic
   Faces
SO INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
LA English
DT Article
DE Human-robot interaction; Facial expression; Emotion; Minimalist design;
   Robot design
ID RECOGNITION; EMOTION; BEHAVIOR; PERCEPTION; AUTISM; REAL
AB This study explores deriving minimal features for a robotic face to convey information (via facial expressions) that people can perceive and understand. Recent research in computer vision has shown that a small number of moving points/lines can be used to capture the majority of information (95 %) in human facial expressions. Here, we apply such findings to a minimalist robot face design, which was run through a series of experiments with human subjects (n = 75) exploring the effect of various factors, including added neck motion and degree of expression. Facial expression identification rates were similar to more complex robots. In addition, added neck motion significantly improved facial expression identification rates to 100 % for all expressions (except Fear). The Negative Attitudes towards Robots (NARS) and Godspeed scales were also collected to examine user perceptions, e.g. perceived animacy and intelligence. The project aims to answer a number of fundamental questions about robotic face design, as well as to develop inexpensive and replicable robotic faces for experimental purposes.
C1 [Bennett, Casey C.; Sabanovic, Selma] Indiana Univ, Sch Informat & Comp, Bloomington, IN 47408 USA.
   [Bennett, Casey C.] Centerstone Res Inst, Dept Informat, Bloomington, IN 47401 USA.
RP Bennett, CC (reprint author), Centerstone Res Inst, Dept Informat, 365 South Pk Ridge Rd, Bloomington, IN 47401 USA.
EM cabennet@indiana.edu
FU Indiana University's School of Informatics and Computing
FX The authors would like to thank Amyra Asamoah, Kay Jessee, and Matthew
   R. Francisco for their assistance in performing this research. Funding
   was provided by Indiana University's School of Informatics and
   Computing.
CR Allison B., 2009, J MECH ROBOT, V1, P1
   Anderson K, 2006, IEEE T SYST MAN CY B, V36, P96, DOI 10.1109/TSMCB.2005.854502
   ARONOFF J, 1992, J PERS SOC PSYCHOL, V62, P1050, DOI 10.1037/0022-3514.62.6.1050
   Barsalou Lawrence W, 2007, Cogn Process, V8, P79, DOI 10.1007/s10339-007-0163-1
   Bartneck D, 2009, INT J SOC ROBOT, V1, P71
   Bazo D, 2010, IEEE INT C INT ROBOT, P5317
   Bechara A, 2000, CEREB CORTEX, V10, P295, DOI 10.1093/cercor/10.3.295
   Becker-Asano C, 2011, IEEE WORKSH AFF COMP, P1, DOI DOI 10.1109/WACI.2011.5953147
   Berns K., 2006, IEEE RSJ INT C INT R, P3119, DOI DOI 10.1109/IROS.2006.282331
   Blow M, 2006, 15 IEEE INT S ROB HU, P469
   Breazeal C, 2009, PHILOS T R SOC B, V364, P3527, DOI 10.1098/rstb.2009.0157
   Breazeal C, 2003, INT J HUM-COMPUT ST, V59, P119, DOI 10.1016/S1071-5819(03)00018-1
   Bryson Joanna J, 2010, International Journal of Strategic Synthetic Emotions, V1, DOI 10.4018/jse.2010101603
   Calder AJ, 2005, NAT REV NEUROSCI, V6, P641, DOI 10.1038/nrn1724
   Canamero D., 1997, Proceedings of the First International Conference on Autonomous Agents, DOI 10.1145/267658.267688
   Canamero L, 2001, IEEE T SYST MAN CY A, V31, P454, DOI 10.1109/3468.952719
   Chaminade T, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011577
   Cohn JF, 2010, IEEE SIGNAL PROC MAG, V27, P128, DOI 10.1109/MSP.2010.938102
   Dautenhahn K, 2007, PHILOS T R SOC B, V362, P679, DOI 10.1098/rstb.2006.2004
   de Gelder B, 2009, PHILOS T R SOC B, V364, P3475, DOI 10.1098/rstb.2009.0190
   Delaunay F, 2009, 18 IEEE INT S ROB HU, P306, DOI DOI 10.1109/ROMAN.2009.5326314
   Di Salvo C. F., 2002, P C DES INT SYST PRO, P321
   Dolan RJ, 2002, SCIENCE, V298, P1191, DOI 10.1126/science.1076358
   Ekman P., 2003, UNMASKING FACE GUIDE
   Ekman P, 2009, PHILOS T R SOC B, V364, P3449, DOI 10.1098/rstb.2009.0189
   Esau N, 2003, FR ART INT, V104, P961
   Faber F., 2009, 18 IEEE INT S ROB HU, P891
   Fong T, 2003, ROBOT AUTON SYST, V42, P143, DOI 10.1016/S0921-8890(02)00372-X
   Fugate JMB, 2013, EMOT REV, V5, P84, DOI 10.1177/1754073912451350
   Gadanho SC, 2001, ADAPT BEHAV, V9, P42
   Gratch J, 2002, IEEE INTELL SYST, V17, P54, DOI 10.1109/MIS.2002.1024753
   Henson RN, 2003, CEREB CORTEX, V13, P793, DOI 10.1093/cercor/13.7.793
   HERMANS D, 1994, COGNITION EMOTION, V8, P515, DOI 10.1080/02699939408408957
   Ishiguro H, 2005, ICCS COGSCI WORKSHOP, P1
   Jack RE, 2009, CURR BIOL, V19, P1543, DOI 10.1016/j.cub.2009.07.051
   Kirby R, 2010, ROBOT AUTON SYST, V58, P322, DOI 10.1016/j.robot.2009.09.015
   Kozima H, 2009, INT J SOC ROBOT, V1, P3, DOI 10.1007/s12369-008-0009-8
   Kwon DS, 2007, P 16 INT S ROB HUM I, P351
   MacDorman KF, 2009, COMPUT HUM BEHAV, V25, P695, DOI 10.1016/j.chb.2008.12.026
   MacDorman KF, 2006, INTERACT STUD, V7, P297, DOI 10.1075/is.7.3.03mac
   Matsumoto N., 2006, Artificial Life and Robotics, V10, DOI 10.1007/s10015-005-0377-1
   Mayer C, 2010, 2010 IEEE RO-MAN, P198, DOI 10.1109/ROMAN.2010.5598629
   Mori M., 1970, ENERGY, V7, P33, DOI DOI 10.1162/PRES.16.4.337
   Movellan JR, 2005, INT C DEVEL LEARN, P80
   Nisbett RE, 2003, GOEGRAPHY THOUGH ASI
   Nomura T., 2003, Proceedings. RO-Man 2003. The 12th IEEE International Workshop on Robot and Human Interactive Communication (IEEE Cat. No. 03TH8711)
   Ogino M, 2008, INT C DEVEL LEARN, P244, DOI 10.1109/DEVLRN.2008.4640837
   Pantic M, 2007, MACHINE ANAL FACIAL, P377
   Pantic M, 2009, PHILOS T R SOC B, V364, P3505, DOI 10.1098/rstb.2009.0135
   Pierno AC, 2008, NEUROPSYCHOLOGIA, V46, P448, DOI 10.1016/j.neuropsychologia.2007.08.020
   Pollack ME, 2002, AAAI WORKSH AUT ELD, P85
   Powers A., 2006, P 1 ACM SIGCHI SIGAR, P218, DOI 10.1145/1121241.1121280
   Robinson P, 2009, PHILOS T R SOC B, V364, P3441, DOI 10.1098/rstb.2009.0198
   Russell J. A., 1997, PSYCHOL FACIAL EXPRE
   RUSSELL JA, 1994, PSYCHOL BULL, V115, P102, DOI 10.1037/0033-2909.115.1.102
   Saint-Aime Sebastien, 2007, 16th IEEE International Conference on Robot and Human Interactive Communication
   Saint-Aime S, 2009, P 14 IASTED INT C RO, P263
   Saldien J, 2010, INT J SOC ROBOT, V2, P377, DOI 10.1007/s12369-010-0067-6
   Scassellati B, 2000, TECHNICAL REPORT
   Scassellati B, 2012, ANNU REV BIOMED ENG, V14, P275, DOI 10.1146/annurev-bioeng-071811-150036
   Scheeff M, 2002, MU S ART SOC SIM ORG, V3, P173
   Shore B., 1996, CULTURE MIND COGNITI
   Sidner C.L., 2006, P HRI 2006, P290, DOI DOI 10.1145/1121241.1121291
   Sidner CL, 2007, CONVERSATIONA INFOR, P103, DOI 10.1002/9780470512470.ch6
   Sosnowski S., 2006, IEEE RSJ INT C INT R, P3113
   Thrun S, 1999, P INT C FIELD SERV R
   Trovato G, 2013, INT J SOC ROBOT, V5, P515, DOI 10.1007/s12369-013-0213-z
   van Breemen A., 2005, P 4 INT JOINT C AUT, P143, DOI 10.1145/1082473.1082823
   Yoshikawa M, 2011, IEEE INT C ROB BIOM, P2378
   Yuki M, 2007, J EXP SOC PSYCHOL, V43, P303, DOI 10.1016/j.jesp.2006.02.004
   Zhang J, 2011, AUTONOMOUS ROBOTIC S, P78
NR 71
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1875-4791
EI 1875-4805
J9 INT J SOC ROBOT
JI Int. J. Soc. Robot.
PD AUG
PY 2014
VL 6
IS 3
SI SI
BP 367
EP 381
DI 10.1007/s12369-014-0237-z
PG 15
WC Robotics
SC Robotics
GA AN3NW
UT WOS:000340496200006
ER

PT J
AU Robins, B
   Dautenhahn, K
AF Robins, Ben
   Dautenhahn, Kerstin
TI Tactile Interactions with a Humanoid Robot: Novel Play Scenario
   Implementations with Children with Autism
SO INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
LA English
DT Article
DE Robot-assisted play; Assistive technology; Human-robot interaction;
   Autism therapy
ID ASSISTED PLAY
AB The work presented in this paper was part of our investigation in the ROBOSKIN project. The project has developed new robot capabilities based on the tactile feedback provided by novel robotic skin, with the aim to provide cognitive mechanisms to improve human-robot interaction capabilities. This article presents two novel tactile play scenarios developed for robot-assisted play for children with autism. The play scenarios were developed against specific educational and therapeutic objectives that were discussed with teachers and therapists. These objectives were classified with reference to the ICF-CY, the International Classification of Functioning-version for Children and Youth. The article presents a detailed description of the play scenarios, and case study examples of their implementation in HRI studies with children with autism and the humanoid robot KASPAR.
C1 [Robins, Ben; Dautenhahn, Kerstin] Univ Hertfordshire, Sch Comp Sci, Adapt Syst Res Grp, Hatfield AL10 9AB, Herts, England.
RP Robins, B (reprint author), Univ Hertfordshire, Sch Comp Sci, Adapt Syst Res Grp, Hatfield AL10 9AB, Herts, England.
EM b.robins@herts.ac.uk; K.Dautenhahn@herts.ac.uk
FU European Commission [FP7-231500-ROBOSKIN]
FX This work has been partially supported by the European Commission under
   contract number FP7-231500-ROBOSKIN
CR Amirabdollahian F, 2009, TACTILE SENSING WORK
   Bannerman-Haig S, 1999, PROCESS ARTS THERAPI
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bernstein P, 1986, THEORETICAL APPROACH
   Boccanfuso L, 2011, INT J SOC ROBOT, V3, P337, DOI 10.1007/s12369-011-0110-2
   Bruner J. S., 1990, ACTS MEANING
   Cabibihan JJ, 2013, INT J SOC ROBOT, V5, P593, DOI 10.1007/s12369-013-0202-2
   Caldwell P, 1996, GETTING TOUCH WAYS W
   Carroll J. M., 1995, SCENARIO BASED DESIG
   Cohen S., 1976, SOCIAL PERSONALITY D
   Costonis M, 1978, THERAPY MOTION
   Cumine V, 2000, AUSTIM EARLY YEARS P
   Dautenhahn Kerstin, 2009, Applied Bionics and Biomechanics, V6, DOI 10.1080/11762320903123567
   Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
   Dietz C, 2004, MITHALY CSIKSZENTMIH
   Eisert D, 1996, EARLY EDUC DEV, V7, P221, DOI DOI 10.1207/S15566935EED0703_2
   Ferland F, 1977, LUDIC MODEL PLAY CHI
   Ferrari E, 2009, 18 IEEE INT WORKSH R
   Fujimoto I, 2011, INT J SOC ROBOT, V3, P349, DOI 10.1007/s12369-011-0116-9
   Howlin P, 1986, SOCIAL BEHAV AUTISM
   Ji Z, 2011, 20 IEE INT S ROB HUM
   Jordan R., 1999, AUTISTIC SPECTRUM DI
   Kozima H, 2009, INT J SOC ROBOT, V1, P3, DOI 10.1007/s12369-008-0009-8
   Landau E., 2001, AUTISM
   Lathan C, 2001, EC NSF WORKSH UN ACC, P80
   Maiolino P, 2012, SMART ACTUATION SENS
   Marti P, 2005, P ANN C EUR ASS COGN
   Meekums B, 2002, DANCE MOVEMENT THEAP
   Michaud F, 2007, CAN MED BIOL ENG C
   Parham D, 2008, PLAY OCCUPATIONAL TH
   Petersson E, 2007, Universal Access in the Information Society, V6, DOI 10.1007/s10209-007-0081-0
   Piaget J, 1962, PLAY DREAMS IMITATIO
   Powell S., 2000, HELPING CHILDREN AUT
   Robins B, 2012, INTERACT STUD, V13, P189, DOI 10.1075/is.13.2.03rob
   Robins B., 2009, 2 INT C ADV CHI ACHI
   Robins B., 2009, P 2 INT C ADV COMP H
   Robins B., 2005, Universal Access in the Information Society, V4, DOI 10.1007/s10209-005-0116-3
   Robins B, 2012, INT C SOC ROB ICSR12
   Robins B, 2004, INTERACT STUD, V5, P161, DOI 10.1075/is.5.2.02rob
   Robins B, 2010, INT C SOC ROB ICSR10, P24
   Robins B, 2007, ENFANCE, V59, P72
   Robins B, 2005, UNIVERSE ACCESS INF, V4, P2
   Robins B, 2010, INT J HUM-COMPUT ST, V68, P873, DOI 10.1016/j.ijhcs.2010.08.001
   Robins B, 2010, 19 IEEE INT S ROB HU
   Rozzo A, 2003, COGNITIVE TASK DESIG
   Scassellati B, 2012, ANNU REV BIOMED ENG, V14, P275, DOI 10.1146/annurev-bioeng-071811-150036
   Stiehl WD, 2009, CREATIVE INTERACTIVE
   Vygotsky L. S., 1978, MIND SOC
   Wing L., 1996, AUTISTIC SPECTRUM
   Winnicott D. W., 1971, PLAYING REALITY
   World Health Organisation, 2001, INT CLASS FUNCT DIS
NR 51
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1875-4791
EI 1875-4805
J9 INT J SOC ROBOT
JI Int. J. Soc. Robot.
PD AUG
PY 2014
VL 6
IS 3
SI SI
BP 397
EP 415
DI 10.1007/s12369-014-0228-0
PG 19
WC Robotics
SC Robotics
GA AN3NW
UT WOS:000340496200008
ER

PT J
AU Wolbring, G
   Yumakulov, S
AF Wolbring, Gregor
   Yumakulov, Sophya
TI Social Robots: Views of Staff of a Disability Service Organization
SO INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
LA English
DT Article
DE Disabled people; People with disabilities; Disability service
   organization; Perception of social robots
ID AUTISM SPECTRUM DISORDERS; CHILDREN; THERAPY; DESIGN; CARE; MACHINES;
   BEHAVIOR
AB Social robotics is an emerging field, with many applications envisioned for people with disabilities. This project examined the so far invisible views of disability service organization workers towards social robotics. Because community service workers' views shape community-based rehabilitation (an area of health interventions that focuses on social determinants), it is important to examine their views towards social robotics applications which are largely developed under a clinical/medical view of disability. We administered a survey to employees of a Saskatchewan disability service organization. Out of 44 respondents, 80 % were female, most aged 21-65 years. Robotics applications perceived to be important included domestic robots, and rehabilitation robots. Least important applications included eldercare robots, companion robots, and pet robots. Most participants felt that robots cannot replace human touch, human interaction, or emotional companionship, and that they cannot/should not replace human workers in the disability setting. Many expressed concerns about safety, normality for disabled people, and artificial interactions. Respondents also had views on whether a social robot can be a bully or could be bullied. We submit that the perspectives our respondents exhibited might be useful to consider in the development of social robots for applications around disability in order to ensure acceptable and relevant products.
C1 [Wolbring, Gregor; Yumakulov, Sophya] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada.
RP Wolbring, G (reprint author), Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada.
EM gwolbrin@ucalgary.ca; syumakul@ucalgary.ca
FU Faculty of Medicine, University of Calgary
FX This work was in part supported by a Bridge funding grant of GW from the
   Faculty of Medicine, University of Calgary; we would like to thank the
   University of Calgary for paying for the Springer open access option
   through their open access fund.
CR Ang M, 2010, LECT NOTES ARTIF INT, V6414, P401
   Angulo BC, 2012, ONGOING RES
   Arendsen J, 2010, ECCE 2010 EUR C COGN, P371
   Blanson OA, 2012, PATIENT INTELL, V4, P51
   Boccanfuso L, 2011, INT J SOC ROBOT, V3, P337, DOI 10.1007/s12369-011-0110-2
   Boccanfuso L, 2010, LECT NOTES ARTIF INT, V6414, P265
   Boyer L, 2004, MIDDLE STATES GEOGR, V37, P72
   Broadbent E, 2009, INT J SOC ROBOT, V1, P319, DOI 10.1007/s12369-009-0030-6
   Bumby K, 1999, CT 99 P 3 INT COGN T, P391
   Carpenter J, 2009, INT J SOC ROBOT, V1, P261, DOI 10.1007/s12369-009-0016-4
   Damm O, 2013, RO MAN, P368
   Danielson P, 2010, ETHICS INF TECHNOL, V12, P251, DOI 10.1007/s10676-009-9214-x
   Dario P, 2001, J ROBOTIC SYST, V18, P673, DOI 10.1002/rob.8106
   Darling K, 2012, WE ROBOT CONFERENCE
   Darling K, 2012, IEEE SPECTRUM
   Dautenhahn K., 2005, 2005 IEEE/RSJ International Conference on Intelligent Robots and Systems, DOI 10.1109/IROS.2005.1545189
   Dautenhahn K., 2005, IEEE RSJ INT C INT R, P1192, DOI DOI 10.1109/IROS.2005.1545189
   Dautenhahn K, 2002, IEEE ROMAN 2002, PROCEEDINGS, P192, DOI 10.1109/ROMAN.2002.1045621
   Dautenhahn K, 2002, P 2002 IEEE INT WORK, P192, DOI 10.1109/ROMAN.2002.1045621
   Decker Michael, 2008, AI & Society, V22, DOI 10.1007/s00146-007-0151-0
   Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
   Duffy BR, 2003, ROBOT AUTON SYST, V42, P177, DOI 10.1016/S0921-8890(02)00374-3
   European Commission, 2012, EURO COMM SPEC EUR, V382
   Feil-Seifer D, 2010, INTERACT STUD, V11, P208, DOI 10.1075/is.11.2.05fei
   Feil-Seifer DJ, 2012, THESIS U SO CALIFORN
   Flandorfer P, 2012, INT J POPUL RES, DOI [10.1155/2012/829835, DOI 10.1155/2012/829835]
   Fong T, 2003, ROBOT AUTON SYST, V42, P143, DOI 10.1016/S0921-8890(02)00372-X
   Fujimoto I, 2011, INT J SOC ROBOT, V3, P349, DOI 10.1007/s12369-011-0116-9
   Fujimoto I, 2010, LECT NOTES ARTIF INT, V6414, P232
   Gelderblom GJ, 2010, LECT NOTES ARTIF INT, V6414, P253
   Giron-Sierra JM, 2000, P 30 ANN FRONT ED C, pS1C
   Heerink M, 2010, INT J SOC ROBOT, V2, P361, DOI 10.1007/s12369-010-0068-5
   Heylen D, 2012, J MULTIMODAL USER IN, V5, P53, DOI 10.1007/s12193-011-0083-3
   Hornfeck K, 2012, ACM, P293
   JaYoung Sung, 2010, International Journal of Social Robotics, V2, DOI 10.1007/s12369-010-0065-8
   Kahn Jr PH, 2004, 13 IEEE INT WORKSH R, P545
   Kahn PH, 2012, P 7 ACM IEEE INT C H, P33, DOI DOI 10.1145/2157689.2157696
   Kamide H, 2010, IEEE RSJ INT C INT R, P5830
   Kanda T, 2007, IEEE T ROBOT, V23, P962, DOI 10.1109/TRO.2007.904904
   Kim ES, 2013, J AUTISM DEV DISORD, V43, P1038, DOI 10.1007/s10803-012-1645-2
   Kim YD, 2010, LECT NOTES ARTIF INT, V6414, P222
   Kozima H, 2007, PROG BRAIN RES, V164, P385, DOI 10.1016/S0079-6123(07)64021-7
   Kozima H, 2009, INT J SOC ROBOT, V1, P3, DOI 10.1007/s12369-008-0009-8
   Leite I, 2012, LNCS, P135
   Le Tallec M, 2011, L N INST COMP SCI SO, V59, P57
   Li J, 2011, INT J SOC ROBOT, V3, P125, DOI 10.1007/s12369-010-0071-x
   Louie WYG, 2012, IEEE, P345
   Melson G. F., 2005, C HUM FACT COMP SYST, P1649, DOI 10.1145/1056808.1056988
   Melson GF, 2009, J APPL DEV PSYCHOL, V30, P92, DOI 10.1016/j.appdev.2008.10.011
   Moon AJ, 2011, INT J SOC ROBOT, V4, P1
   Mordoch E, 2012, MATURITAS, V74, P14
   Ott I, 2012, POIESIS PRAX, V9, P219
   Qianli X, 2012, NETW ERG SOC C SEANE, P1, DOI [10.1109/SEANES.2012.6299594, DOI 10.1109/SEANES.2012.6299594]
   Ray C, 2008, 2008 IEEE/RSJ INTERNATIONAL CONFERENCE ON ROBOTS AND INTELLIGENT SYSTEMS, VOLS 1-3, CONFERENCE PROCEEDINGS, P3816, DOI 10.1109/IROS.2008.4650714
   Salvini P, 2010, RO MAN, P1
   Salvini P, 2010, INT J SOC ROBOT, V2, P451, DOI 10.1007/s12369-010-0079-2
   Sekiyama K, 1999, APPL ARTIF INTELL, V13, P213, DOI 10.1080/088395199117405
   Shamsuddin S., 2012, P ENG, V41, P1448
   Shaw-Garlock G, 2011, L N INST COMP SCI SO, V59, P1
   Sparrow R, 2006, MIND MACH, V16, P141, DOI 10.1007/s11023-006-9030-6
   Stanton C., 2008, 3 ACM IEEE INT C HUM, P271
   Tapus A, 2007, IEEE ROBOT AUTOM MAG, V14, P35, DOI 10.1109/MRA.2007.339605
   Thill S, 2013, PALADYN, V4, P209
   Turkle S, 2006, CONNECT SCI, V18, P347, DOI 10.1080/09540090600868912
   Vardoulakis L, 2012, INTELL VIRTUAL AGENT, V7502, P289
   Weiss A, 2011, INT J SOC ROBOT, V3, P111, DOI 10.1007/s12369-010-0076-5
   Weiss A, 2010, INT J SOC ROBOT, V2, P345, DOI 10.1007/s12369-010-0083-6
   Welch KC, 2010, INT J SOC ROBOT, V2, P391, DOI 10.1007/s12369-010-0063-x
   Wolbring Gregor, 2013, J Pers Med, V3, P23, DOI 10.3390/jpm3010023
   Wolbring G, 2013, J CRITIC AN IN PRESS
   Wu YH, 2012, ARCH GERONTOL GERIAT, V54, P121, DOI 10.1016/j.archger.2011.02.003
   Yumakulov S., 2012, LECT NOTES COMPUTER, V7621, P168
   Ziaja S, 2011, SOCIAL ROBOTICS LECT, V7072, P114
NR 73
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1875-4791
EI 1875-4805
J9 INT J SOC ROBOT
JI Int. J. Soc. Robot.
PD AUG
PY 2014
VL 6
IS 3
SI SI
BP 457
EP 468
DI 10.1007/s12369-014-0229-z
PG 12
WC Robotics
SC Robotics
GA AN3NW
UT WOS:000340496200012
ER

PT J
AU Buescher, AVS
   Cidav, Z
   Knapp, M
   Mandell, DS
AF Buescher, Ariane V. S.
   Cidav, Zuleyha
   Knapp, Martin
   Mandell, David S.
TI Costs of Autism Spectrum Disorders in the United Kingdom and the United
   States
SO JAMA PEDIATRICS
LA English
DT Article
ID HEALTH-CARE UTILIZATION; PSYCHIATRIC-HOSPITALIZATION; CHILDREN;
   EXPENDITURES; EMPLOYMENT; SERVICE; UK; EXPERIENCES; ADULTS; HOME
AB IMPORTANCE The economic effect of autism spectrum disorders (ASDs) on individuals with the disorder, their families, and society as a whole is poorly understood and has not been updated in light of recent findings.
   OBJECTIVE To update estimates of age-specific, direct, indirect, and lifetime societal economic costs, including new findings on indirect costs, such as individual and parental productivity costs, associated with ASDs.
   DESIGN, SETTING, AND PARTICIPANTS A literature review was conducted of US and UK studies on individuals with ASDs and their families in October 2013 using the following keywords: age, autism spectrum disorder, prevalence, accommodation, special education, productivity loss, employment, costs, and economics. Current data on prevalence, level of functioning, and place of residence were combined with mean annual costs of services and support, opportunity costs, and productivity losses of individuals with ASDs with or without intellectual disability.
   EXPOSURE Presence of ASDs.
   MAIN OUTCOMES AND MEASURES Mean annual medical, nonmedical, and indirect economic costs and lifetime costs were measured for individuals with ASDs separately for individuals with and without intellectual disability in the United States and the United Kingdom.
   RESULTS The cost of supporting an individual with an ASD and intellectual disability during his or her lifespan was $2.4 million in the United States and 1.5 pound million (US $2.2 million) in the United Kingdom. The cost of supporting an individual with an ASD without intellectual disability was $1.4 million in the United States and 0.92 pound million (US $1.4 million) in the United Kingdom. The largest cost components for children were special education services and parental productivity loss. During adulthood, residential care or supportive living accommodation and individual productivity loss contributed the highest costs. Medical costs were much higher for adults than for children.
   CONCLUSIONS AND RELEVANCE The substantial direct and indirect economic effect of ASDs emphasizes the need to continue to search for effective interventions that make best use of scarce societal resources. The distribution of economic effect across many different service systems raises questions about coordination of services and sectors. The enormous effect on families also warrants policy attention.
C1 [Buescher, Ariane V. S.; Knapp, Martin] Univ London London Sch Econ & Polit Sci, Personal Social Serv Res Unit, London WC2A 2AE, England.
   [Cidav, Zuleyha; Mandell, David S.] Univ Penn, Ctr Mental Hlth Policy & Serv Res, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Cidav, Zuleyha; Mandell, David S.] Childrens Hosp Philadelphia, Ctr ASD Res, Philadelphia, PA 19104 USA.
RP Mandell, DS (reprint author), Univ Penn, Ctr Mental Hlth Policy & Serv Res, 3535 Market St, Philadelphia, PA 19104 USA.
EM mandelld@upenn.edu
RI Mandell, David/H-2730-2012
OI Mandell, David/0000-0001-8240-820X
FU Autism Speaks; Steve Shirley Foundation
FX This study was funded by Autism Speaks. Estimates for the United Kingdom
   were built on previous research funded by the Steve Shirley Foundation.
CR Amendah D, 2011, AUTISM SPECTRUM DISO
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Barrett B, 2012, J AUTISM DEV DISORD, V42, P797, DOI 10.1007/s10803-011-1306-x
   Birenbaum A., 1990, SHADOW MED REMAKING
   Brugha T, 2012, ESTIMATING PREVALENC
   Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
   Chambers J, 2003, TOTAL EXPENDITURES S
   Chambers J, 2004, WHAT ARE WE SPENDING
   Cidav Z, 2013, J AUTISM DEV DISORD, V43, P924, DOI 10.1007/s10803-012-1637-2
   Cidav Z, 2012, PEDIATRICS, V129, P617, DOI 10.1542/peds.2011-2700
   Cone AA, 2008, FACT SHEET SUPPORTED
   Croen LA, 2006, PEDIATRICS, V118, pE1203, DOI 10.1542/peds.2006-0127
   Curtis L, 2011, UNIT COST HLTH SOCIA
   Department for Education, 2011, CHILDR SPEC ED NEEDS
   Department for Educationc, 2005, CHILDR NEED CIN DIS
   Emerson E., 2010, ESTIMATED PREVALENCE
   Felce D, 2008, AM J MENT RETARD, V113, P87, DOI 10.1352/0895-8017(2008)113[87:OACOCL]2.0.CO;2
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Ganz M., 2006, UNDERSTANDING AUTISM
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Ham C, 2005, BRIT MED J, V330, P597, DOI 10.1136/bmj.330.7491.597
   Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
   Hyman SL, 2012, J AUTISM DEV DISORD, V42, P1156, DOI 10.1007/s10803-012-1474-3
   Jacobson J, 1998, BEHAV INTERVENT, V13, P201, DOI DOI 10.1002/(SICI)1099-078X
   Jarbrink K, 2007, AUTISM, V11, P453, DOI 10.1177/1362361307079602
   Jarbrink K, 2003, J AUTISM DEV DISORD, V33, P395, DOI 10.1023/A:1025058711465
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246
   Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
   Lakin KC, 2008, INTELLECT DEV DISAB, V46, P200, DOI 10.1352/2008.46:200-214
   Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
   Mandell DS, 2008, J AUTISM DEV DISORD, V38, P1059, DOI 10.1007/s10803-007-0481-2
   Mandell DS, 2012, ARCH PEDIAT ADOL MED, V166, P68, DOI 10.1001/archpediatrics.2011.714
   National Autistic Society, 2012, AUT ASP SYNDR SOM FA
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Office for National Statistics, 2011, ANN SURV HOURS EARN
   Organisation for Economic Cooperation and Development, 2012, PPPS EXCH RAT
   Peacock G, 2012, J DEV BEHAV PEDIATR, V33, P2, DOI 10.1097/DBP.0b013e31823969de
   Perou Ruth, 2013, MMWR Surveill Summ, V62 Suppl 2, P1
   Peters-Scheffer N, 2012, RES DEV DISABIL, V33, P1763, DOI 10.1016/j.ridd.2012.04.006
   Roux AM, 2013, J AM ACAD CHILD PSY, V52, P931, DOI 10.1016/j.jaac.2013.05.019
   Shattuck PT, 2007, MENT RETARD DEV D R, V13, P129, DOI 10.1002/mrdd.20143
   Shavelle R M, 1998, J Insur Med, V30, P220
   Synergies Economic Consulting, 2011, EC COSTS AUT SPECTR, P1
   Taylor B, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003219
   Treasury HM, 2004, GREEN BOOK APPR EV C
NR 47
TC 15
Z9 16
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6203
EI 2168-6211
J9 JAMA PEDIATR
JI JAMA Pediatr.
PD AUG
PY 2014
VL 168
IS 8
BP 721
EP 728
DI 10.1001/jamapediatrics.2014.210
PG 8
WC Pediatrics
SC Pediatrics
GA AN0TZ
UT WOS:000340298200011
PM 24911948
ER

PT J
AU Millard, H
   McLaren, JL
   Coffey, BJ
AF Millard, Hun
   McLaren, Jennifer L.
   Coffey, Barbara J.
TI Lurasidone Treatment in a Child with Autism Spectrum Disorder with
   Irritability and Aggression
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
C1 [Millard, Hun; McLaren, Jennifer L.] Geisel Sch Med Dartmouth, Dept Psychiat, Lebanon, NH USA.
   [Coffey, Barbara J.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
RP Coffey, BJ (reprint author), Icahn Sch Med Mt Sinai, One Gustave L Levy Pl,Box 1230, New York, NY 10029 USA.
EM Barbara.coffey@mssm.edu
FU Boehringer Ingelheim; Bristol-Myers; Eli Lilly Pharmaceutical; National
   Institute of Mental Health (NIMH); National Institute of Neurological
   Disorders and Stroke (NINDS); Otsuka; Pfizer; Shire; Tourette Syndrome
   Association
FX Drs. Millard and McLaren have no conflicts of interest or financial ties
   to disclose. Dr. Coffey has received research support from Boehringer
   Ingelheim, Bristol-Myers, Eli Lilly Pharmaceutical, National Institute
   of Mental Health (NIMH), National Institute of Neurological Disorders
   and Stroke (NINDS), Otsuka, Pfizer, Shire, and Tourette Syndrome
   Association.
CR Baribeau DA, 2014, CURR PSYCHIAT REP, V16, DOI 10.1007/s11920-014-0437-0
   Doyle CA, 2012, EXPERT OPIN PHARMACO, V13, P1615, DOI 10.1517/14656566.2012.674110
   Politte LC, 2014, PSYCHOPHARMACOLOGY, V231, P1023, DOI 10.1007/s00213-013-3068-y
   Stahl SM, 2013, STAHLS ESSENTIAL PSY
NR 4
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD AUG
PY 2014
VL 24
IS 6
BP 354
EP 356
DI 10.1089/cap.2014.2462
PG 3
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA AN7ZW
UT WOS:000340820700009
ER

PT J
AU Otsuka, Y
   Mareschal, I
   Calder, AJ
   Clifford, CWG
AF Otsuka, Yumiko
   Mareschal, Isabelle
   Calder, Andrew J.
   Clifford, Colin W. G.
TI Dual-Route Model of the Effect of Head Orientation on Perceived Gaze
   Direction
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE
LA English
DT Article
DE gaze perception; cue combination; head orientation; Wollaston effect;
   dual-route model
ID UNIQUE MORPHOLOGY; TEMPORAL CORTEX; EYE DIRECTION; PERCEPTION; LOOKING;
   AUTISM; JUDGMENT; FACE; ACCURACY; CHILDREN
AB Previous studies on gaze perception have identified 2 opposing effects of head orientation on perceived gaze direction-1 repulsive and the other attractive. However, the relationship between these 2 effects has remained unclear. By using a gaze categorization task, the current study examined the effect of head orientation on the perceived direction of gaze in a whole-head condition and an eye-region condition. We found that the perceived direction of gaze was generally biased in the opposite direction to head orientation (a repulsive effect). Importantly, the magnitude of the repulsive effect was more pronounced in the eye-region condition than in the whole-head condition. Based on these findings, we developed a dual-route model, which proposes that the 2 opposing effects of head orientation occur through 2 distinct routes. In the framework of this dual-route model, we explain and reconcile the findings from previous studies, and provide a functional account of attractive and repulsive effects and their interaction.
C1 [Otsuka, Yumiko; Clifford, Colin W. G.] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
   [Mareschal, Isabelle] Univ Sydney, Sydney, NSW 2006, Australia.
   [Mareschal, Isabelle] Queen Mary Univ London, Dept Psychol, Sch Chem & Biol Sci, London, England.
   [Calder, Andrew J.] MRC Cognit & Brain Sci Unit, Cambridge, England.
   [Clifford, Colin W. G.] Univ Sydney, Australian Ctr Excellence Vis Sci, Sydney, NSW 2006, Australia.
RP Otsuka, Y (reprint author), Univ New S Wales, Sch Psychol, Mathews Bldg, Sydney, NSW 2052, Australia.
EM yumikoot@gmail.com
RI Otsuka, Yumiko/J-5628-2014
FU Australian Research Council [DP120102589]; Medical Research Council,
   United Kingdom [MC_US_A060_5PQ50]
FX This work is supported by Australian Research Council Discovery Project
   [DP120102589] to Colin Clifford and Andrew Calder; Colin Clifford is
   supported by an Australian Research Council Future Fellowship; Andrew
   Calder is supported by the Medical Research Council, United Kingdom
   [grant ref. MC_US_A060_5PQ50].
CR ANSTIS SM, 1969, AM J PSYCHOL, V82, P474, DOI 10.2307/1420441
   Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
   Campbell R, 2006, DEV PSYCHOPATHOL, V18, P99, DOI 10.1017/S0954579406060068
   Carlin JD, 2011, CURR BIOL, V21, P1817, DOI 10.1016/j.cub.2011.09.025
   CLINE MG, 1967, AM J PSYCHOL, V80, P41, DOI 10.2307/1420539
   MARUYAMA K, 1983, Tohoku Psychologica Folia, V42, P126
   Ewbank MP, 2009, J VISION, V9, DOI 10.1167/9.12.16
   Gamer M, 2007, J EXP PSYCHOL HUMAN, V33, P705, DOI 10.1037/0096-1523.33.3.705
   GIBSON JJ, 1963, AM J PSYCHOL, V76, P386, DOI 10.2307/1419779
   Kluttz NL, 2009, VISION RES, V49, P1979, DOI 10.1016/j.visres.2009.05.013
   Kobayashi H, 2001, J HUM EVOL, V40, P419, DOI 10.1006/jhev.2001.0468
   Kobayashi H, 1997, NATURE, V387, P767, DOI 10.1038/42842
   Langton SRH, 2000, Q J EXP PSYCHOL-A, V53, P825, DOI 10.1080/027249800410562
   Langton SRH, 2004, PERCEPT PSYCHOPHYS, V66, P752, DOI 10.3758/BF03194970
   Lobmaier JS, 2008, EMOTION, V8, P573, DOI 10.1037/1528-3542.8.4.573
   Mareschal I, 2013, CURR BIOL, V23, P717, DOI 10.1016/j.cub.2013.03.030
   Mareschal I, 2013, J VISION, V13, DOI 10.1167/13.5.18
   MARTIN WW, 1982, BRIT J SOC PSYCHOL, V21, P293
   MARTIN WW, 1981, J NONVERBAL BEHAV, V5, P155, DOI 10.1007/BF00986132
   MARTIN W, 1982, J PSYCHOL, V110, P203
   NOLL AM, 1976, AM J PSYCHOL, V89, P631, DOI 10.2307/1421462
   Pellicano E, 2013, NEUROPSYCHOLOGIA, V51, P1504, DOI 10.1016/j.neuropsychologia.2013.03.021
   PERRETT DI, 1992, PHILOS T ROY SOC B, V335, P23, DOI 10.1098/rstb.1992.0003
   PERRETT DI, 1985, PROC R SOC SER B-BIO, V223, P293, DOI 10.1098/rspb.1985.0003
   Ricciardelli P, 2008, Q J EXP PSYCHOL, V61, P491, DOI 10.1080/17470210701255457
   Scherf KS, 2008, AUTISM RES, V1, P114, DOI 10.1002/aur.17
   Senju A, 2003, COGNITION, V89, pB43, DOI 10.1016/S0010-0277(03)00081-7
   Seyama J, 2005, VIS COGN, V12, P103, DOI 10.1080/13506280444000111
   Slepian ML, 2011, EMOTION, V11, P1439, DOI 10.1037/a0026163
   Stoyanova RS, 2010, PSYCHOL SCI, V21, P1765, DOI 10.1177/0956797610388812
   Todorovic D, 2006, VISION RES, V46, P3549, DOI 10.1016/j.visres.2006.04.011
   Todorovic D, 2009, PERCEPTION, V38, P109, DOI 10.1068/p5930
   Troje NF, 1998, PERCEPTION, V27, P671, DOI 10.1068/p270671
   Vida MD, 2012, J EXP CHILD PSYCHOL, V111, P299, DOI 10.1016/j.jecp.2011.08.009
   Webster S, 2008, J AUTISM DEV DISORD, V38, P1184, DOI 10.1007/s10803-008-0539-9
   Wollaston W. H., 1824, PHILOS T ROY SOC LON, V114, P247, DOI DOI 10.1098/RSTL.1824.0016
   World Medical Association, 2008, DECL HELS ETH PRINC
NR 37
TC 2
Z9 2
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-1523
EI 1939-1277
J9 J EXP PSYCHOL HUMAN
JI J. Exp. Psychol.-Hum. Percept. Perform.
PD AUG
PY 2014
VL 40
IS 4
BP 1425
EP 1439
DI 10.1037/a0036151
PG 15
WC Psychology; Psychology, Experimental
SC Psychology
GA AN3FR
UT WOS:000340471300015
PM 24730742
ER

PT J
AU Rutkowski, EM
   Brimer, D
AF Rutkowski, Elaine M.
   Brimer, Debbie
TI Physical Education Issues for Students With Autism: School Nurse
   Challenges
SO JOURNAL OF SCHOOL NURSING
LA English
DT Article
DE autism spectrum disorder (ASD); Individualized Education Plan (IEP);
   physical education (PE)
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; ASPERGERS-DISORDER; MOTOR;
   CHILDREN; PREVALENCE
AB Extant studies indicate persons with autism have difficulties in social interaction, verbal and nonverbal communication, repetitive behaviors, and poor ability to generalize learned skills. Obesity has also been identified as significantly affecting children with autism spectrum disorders (ASD). Negative experience in physical education (PE) may be the antecedent behavior to lack of activities that are mediators to sedentary lifestyles and contributors to the chronic illnesses associated with overweight and obesity. Students with ASD often cannot perform required activities to meet required PE standards. It is imperative school nurses be aware of the many challenges students with ASD bring into a PE class. School nurses provide education for the members of the school community, including the Individualized Education Plan team, regarding the need for attention to limitations, including physical activity, of students with ASD.
C1 [Rutkowski, Elaine M.] Calif State Univ Fullerton, Fullerton, CA 92834 USA.
   [Brimer, Debbie] Antelope Valley Union High Sch Dist, Lancaster, CA USA.
RP Rutkowski, EM (reprint author), Calif State Univ Fullerton, POB 6868, Fullerton, CA 92834 USA.
EM erutkowski@fullerton.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Bejerot S, 2011, ACTA PAEDIATR, V100, P413, DOI 10.1111/j.1651-2227.2010.02016.x
   Bellando J, 2009, J SPEC PEDIATR NURS, V14, P173, DOI 10.1111/j.1744-6155.2009.00195.x
   Bellando J, 2009, J SPEC PEDIATR NURS, V14, P210, DOI 10.1111/j.1744-6155.2009.00201.x
   Blumberg SJ, 2013, NATL HLTH STAT REPOR
   Cade M, 2001, J Sch Health, V71, P96
   Centers for Disease Control and Prevention, 2012, MORBIDITY MORTALITY
   Deokar AM, 2008, PEDIATR CLIN N AM, V55, P1147, DOI 10.1016/j.pcl.2008.07.006
   Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
   Green D., 2008, DEV MED CHILD NEUROL, V51, P311
   Guthrie S., 2013, SCH NURSING COMPREHE
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Lang R, 2010, RES AUTISM SPECT DIS, V4, P565, DOI 10.1016/j.rasd.2010.01.006
   Lopata C, 2007, PERCEPT MOTOR SKILL, V104, P1183, DOI 10.2466/PMS.104.4.1183-1192
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   National Association for Sport and Physical Education, 2004, NAT STAND PHYS ED
   National Autism Center, 2011, EV BAS PRACT AUT SCH, P1
   Nayate A, 2005, BRAIN RES BULL, V67, P327, DOI 10.1016/j.brainresbull.2005.07.011
   Obrusnikova I, 2011, ADAPT PHYS ACT Q, V28, P113
   Pan CY, 2011, RES Q EXERCISE SPORT, V82, P491
   Phetrasuwan S, 2009, J SPEC PEDIATR NURS, V14, P206, DOI 10.1111/j.1744-6155.2009.00200.x
   Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
   Sahlander Carina, 2008, Physiotherapy Theory and Practice, V24, P73, DOI 10.1080/15368370701380843
   Scarpinato N, 2010, J SPEC PEDIATR NURS, V15, P244, DOI 10.1111/j.1744-6155.2010.00244.x
   Siedentop D., 2009, J PHYS ACT HEALTH, V6, P168
   Strunk JA, 2009, J SCH NURS, V25, P445, DOI 10.1177/1059840509348221
   United States Department of Education, 2003, 25 C IMPL IND DIS ED
   University of Michigan, 1994, SURV COGN AG ARCH
   Wilczynski SM, 2007, PSYCHOL SCHOOLS, V44, P653, DOI 10.1002/pits
   Winnick JP, 2005, ADAPT PHYS ACT Q, V22, P315
   Zhang J. B., 2007, Journal of Physical Education, Recreation & Dance, V78, P33
NR 32
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1059-8405
EI 1546-8364
J9 J SCH NURS
JI J. Sch. Nurs.
PD AUG
PY 2014
VL 30
IS 4
BP 256
EP 261
DI 10.1177/1059840513503686
PG 6
WC Nursing
SC Nursing
GA AN6QE
UT WOS:000340719800004
PM 24014552
ER

PT J
AU Chiu, YN
   Chou, MC
   Lee, JC
   Wong, CC
   Chou, WJ
   Wu, YY
   Chien, YL
   Gau, SSF
AF Chiu, Yen-Nan
   Chou, Miao-Chun
   Lee, Ju-Chin
   Wong, Ching-Ching
   Chou, Wen-Jiun
   Wu, Yu-Yu
   Chien, Yi-Ling
   Gau, Susan Shur-Fen
TI Determinants of maternal satisfaction with diagnosis disclosure of
   autism
SO JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
LA English
DT Article
DE autism; disclosure; informed counseling; mothers; satisfaction
ID SEVERE MENTAL HANDICAP; DOWNS-SYNDROME; SPECTRUM DISORDER; PARENTING
   STYLE; 1ST INFORMATION; CHILDREN; DISABILITY; FAMILIES; COMMUNICATION;
   PROFESSIONALS
AB Background/Purpose: Diagnosis disclosure is an important clinical issue in developmental disabilities, which may influence parents' ability to cope with their child's conditions. This paper presents the content and patterns of diagnosis-informed counseling for mothers of children with autism and investigates the determinants for maternal satisfaction with this counseling, in order to improve clinical practice.
   Methods: Mothers of 151 children, aged 3-12 years, with DSM-IV autistic disorder, confirmed by the Chinese version of the Autism Diagnostic Interview-Revised, were assessed. We collected information about the mothers' experience with diagnosis-informed counseling, their personality characteristics, and the extent to which they were satisfied with the counseling.
   Results: Satisfaction with diagnosis-informed counseling was related more to the context of the counseling, including the attitude of the counselors and the timing and duration of counseling, than to its content. Parents' social desirability, educational level, and employment status were negatively associated with their satisfaction with counseling. However, immediate emotion, neuroticism, and extroversion did not have a significant effect on the satisfaction with counseling. Approximately 60% of the mothers preferred to be informed of having an autistic child after the diagnosis had been confirmed.
   Conclusion: Our findings suggest that more efforts are needed to improve the quality of diagnosis-informed counseling in autism, particularly in the context of breaking the news to mothers of children with autism. Future study could further examine the moderating effect of diagnostic subtype of autism spectrum disorders, treatment response, or social support on maternal satisfaction with diagnosis-informed counseling (ClinicalTrials.gov number, NCT00494754). Copyright (C) 2012, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
C1 [Chiu, Yen-Nan; Chien, Yi-Ling; Gau, Susan Shur-Fen] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan.
   [Chiu, Yen-Nan; Chien, Yi-Ling; Gau, Susan Shur-Fen] Coll Med, Taipei, Taiwan.
   [Chou, Miao-Chun; Chou, Wen-Jiun] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, Kaohsiung, Taiwan.
   [Chou, Miao-Chun; Chou, Wen-Jiun] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Lee, Ju-Chin] Wan Fang Hosp, Dept Psychiat, Taipei, Taiwan.
   [Wong, Ching-Ching] Taipei City Hosp, Branch Women & Children, Taipei Child Assessment & Early Intervent Ctr, Taipei, Taiwan.
   [Wu, Yu-Yu] Chang Gung Mem Hosp, Dept Child Psychiat, Linkou Med Ctr, Taoyuan, Taiwan.
RP Chien, YL (reprint author), Natl Taiwan Univ Hosp, Dept Psychiat, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM ylchien@hotmail.com
FU National Science Council (gs1), Taiwan [NSC96-3112-B-002-033,
   NSC97-3112-B-002-009, N5C98-3112-B-002-004]
FX This work was supported by grants from the National Science Council
   (gs1) (NSC96-3112-B-002-033; NSC96-3112-B-002-033; NSC97-3112-B-002-009;
   N5C98-3112-B-002-004), Taiwan.
CR Brogan CA, 2003, AUTISM, V7, P31, DOI 10.1177/1362361303007001004
   CHAO RK, 1994, CHILD DEV, V65, P1111, DOI 10.1111/j.1467-8624.1994.tb00806.x
   Chen Kao Ching, 2008, Depress Anxiety, V25, pE56, DOI 10.1002/da.20312
   COTTRELL DJ, 1990, CHILD CARE HLTH DEV, V16, P211, DOI 10.1111/j.1365-2214.1990.tb00655.x
   CUNNINGHAM CC, 1977, CHILD CARE HLTH DEV, V3, P325, DOI 10.1111/j.1365-2214.1977.tb00056.x
   CUNNINGHAM CC, 1984, DEV MED CHILD NEUROL, V26, P33
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   DEROGATIS L R, 1973, Psychopharmacology Bulletin, V9, P13
   Eysenck SGB, 1965, MANUAL JUNIOR EVSENC
   FOST N, 1981, PEDIATRICS, V67, P321
   Futagi Yasuyuki, 2002, No To Hattatsu, V34, P336
   Gau SS, 2005, TAIWANESE J PSYCHIAT, V19, P204
   Gau SSF, 2010, PSYCHIAT CLIN NEUROS, V64, P70, DOI 10.1111/j.1440-1819.2009.02034.x
   Gau SSF, 2009, COMPR PSYCHIAT, V50, P276, DOI 10.1016/j.comppsych.2008.08.009
   Gau SSF, 2008, J AM COLL HEALTH, V57, P135, DOI 10.3200/JACH.57.2.135-142
   Gokcen S, 2009, PSYCHIAT RES, V166, P46, DOI 10.1016/j.psychres.2007.11.016
   Hasnat MJ, 2000, J PAEDIATR CHILD H, V36, P32, DOI 10.1046/j.1440-1754.2000.00463.x
   Hedov G, 2002, ACTA PAEDIATR, V91, P1344
   Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
   Lavi E, 2005, HAREFUAH, V144, P383
   Lavi Elana, 2005, Harefuah, V144, P322
   Lee MB, 2003, J FORMOS MED ASSOC, V102, P687
   Lee M B, 1990, J Formos Med Assoc, V89, P1081
   Liao SC, 2002, J FORMOS MED ASSOC, V101, P169
   Lin CR, 2008, J CLIN NURS, V17, P2733, DOI 10.1111/j.1365-2702.2008.02456.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   MCKAY M, 1990, CHILD CARE HLTH DEV, V16, P373, DOI 10.1111/j.1365-2214.1990.tb00670.x
   Miles JH, 2008, AM J MED GENET A, V146A, P1101, DOI 10.1002/ajmg.a.32244
   MURDOCH JC, 1983, J MENT DEFIC RES, V27, P247
   Osborne LA, 2008, AUTISM, V12, P309, DOI 10.1177/1362361307089517
   QUINE L, 1987, DEV MED CHILD NEUROL, V29, P232
   QUINE L, 1986, SOC SCI MED, V22, P53, DOI 10.1016/0277-9536(86)90308-4
   SLOPER P, 1993, DEV MED CHILD NEUROL, V35, P816
   SMITH B, 1978, CHILD CARE HLTH DEV, V4, P195, DOI 10.1111/j.1365-2214.1978.tb00077.x
   Spahis JK, 1999, AM J MED GENET, V89, P96, DOI 10.1002/(SICI)1096-8628(19990625)89:2<96::AID-AJMG7>3.0.CO;2-4
   Taanila A, 2002, ACTA PAEDIATR, V91, P1289
   TARRAN EC, 1981, DEV MED CHILD NEUROL, V23, P173
   Toriello NV., 2008, PEDIATR CLIN N AM, V55, P1085
   Toriello NV., 2008, PEDIATR CLIN N AM, V55, pxi
   Tsai HF, 2009, PSYCHIAT RES, V167, P294, DOI 10.1016/j.psychres.2008.01.015
   Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
NR 41
TC 0
Z9 0
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 0929-6646
J9 J FORMOS MED ASSOC
JI J. Formos. Med. Assoc.
PD AUG
PY 2014
VL 113
IS 8
BP 540
EP 548
DI 10.1016/j.jfma.2012.07.040
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA AO1HF
UT WOS:000341062500009
PM 25037759
ER

PT J
AU Wolf, EJ
   Mitchell, KS
   Logue, MW
   Baldwin, CT
   Reardon, AF
   Aiello, A
   Galea, S
   Koenen, KC
   Uddin, M
   Wildman, D
   Miller, MW
AF Wolf, Erika J.
   Mitchell, Karen S.
   Logue, Mark W.
   Baldwin, Clinton T.
   Reardon, Annemarie F.
   Aiello, Alison
   Galea, Sandro
   Koenen, Karestan C.
   Uddin, Monica
   Wildman, Derek
   Miller, Mark W.
TI The Dopamine D-3 Receptor Gene and Posttraumatic Stress Disorder
SO JOURNAL OF TRAUMATIC STRESS
LA English
DT Article
ID MULTILOCUS GENOTYPE DATA; NICOTINE DEPENDENCE; NUCLEUS-ACCUMBENS; MAJOR
   DEPRESSION; SEX-DIFFERENCES; SCHIZOPHRENIA; D3; ASSOCIATION; DRD3;
   POPULATION
AB The dopamine D-3 receptor (DRD3) gene has been implicated in schizophrenia, autism, and substance use-disorders and is related to emotion reactivity, executive functioning, and stress-responding, processes impaired in posttraumatic stress disorder (PTSD). The aim of this candidate gene study was to evaluate DRD3 polymorphisms for association with PTSD. The discovery sample was trauma-exposed White, non-Hispanic U.S. veterans and their trauma-exposed intimate partners (N = 491); 60.3% met criteria for lifetime PTSD. The replication sample was 601 trauma-exposed African American participants living in Detroit, Michigan; 23.6% met criteria for lifetime PTSD. Genotyping was based on high-density bead chips. In the discovery sample, 4 single nucleotide polymorphisms (SNPs), rs2134655, rs201252087, rs4646996, and rs9868039, showed evidence of association with PTSD and withstood correction for multiple testing. The minor alleles were associated with reduced risk for PTSD (OR range= 0.59 to 0.69). In the replication sample, rs2251177, located 149 base pairs away from the most significant SNP in the discovery sample, was nominally associated with PTSD in men (OR = 0.32). Although the precise role of the D3 receptor in PTSD is not yet known, its role in executive functioning and emotional reactivity, and the sensitivity of the dopamine system to environmental stressors could potentially explain this association.
C1 [Wolf, Erika J.; Mitchell, Karen S.; Reardon, Annemarie F.; Miller, Mark W.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
   [Wolf, Erika J.; Mitchell, Karen S.; Miller, Mark W.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Logue, Mark W.; Baldwin, Clinton T.] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Baldwin, Clinton T.] Boston Univ, Sch Med, Ctr Human Genet, Boston, MA 02118 USA.
   [Aiello, Alison] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Galea, Sandro; Koenen, Karestan C.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Uddin, Monica; Wildman, Derek] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI USA.
   [Uddin, Monica] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA.
RP Miller, MW (reprint author), 150 South Huntington Ave 116B-2, Boston, MA 02130 USA.
EM Mark.Miller5@va.gov
CR Agrawal A, 2013, ADDICT BEHAV, V38, P1501, DOI 10.1016/j.addbeh.2012.03.021
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
   Beninger R J, 1983, Brain Res, V287, P173
   Berridge KC, 1998, BRAIN RES REV, V28, P309, DOI 10.1016/S0165-0173(98)00019-8
   Black KJ, 2002, P NATL ACAD SCI USA, V99, P17113, DOI 10.1073/pnas.012260599
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Bombin I, 2008, AM J MED GENET B, V147B, P873, DOI 10.1002/ajmg.b.30710
   Breslau N, 1998, ARCH GEN PSYCHIAT, V55, P626, DOI 10.1001/archpsyc.55.7.626
   Bristow LJ, 1996, NEUROPHARMACOLOGY, V35, P285, DOI 10.1016/0028-3908(96)00179-7
   Brown AK, 2012, INT J NEUROPSYCHOPH, V15, P989, DOI 10.1017/S1461145711001957
   Costas J, 2009, HUM GENET, V124, P607, DOI 10.1007/s00439-008-0584-7
   CROCQ MA, 1992, J MED GENET, V29, P858, DOI 10.1136/jmg.29.12.858
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Dalley JW, 2007, SCIENCE, V315, P1267, DOI 10.1126/science.1137073
   Dannlowski U., 2011, INT J NEUROPSYCHOPH, V18, P1, DOI 10.1017/S1461145711001659
   de Krom M, 2009, BIOL PSYCHIAT, V65, P625, DOI 10.1016/j.biopsych.2008.09.035
   Dikeos DG, 1999, PSYCHIATR GENET, V9, P189, DOI 10.1097/00041444-199912000-00005
   Dominguez E, 2007, SCHIZOPHR RES, V90, P123, DOI 10.1016/j.schres.2006.09.022
   Ersche KD, 2011, PSYCHOPHARMACOLOGY, V214, P779, DOI 10.1007/s00213-010-2087-1
   Falush D, 2003, GENETICS, V164, P1567
   Furuyashiki T, 2012, J PHARMACOL SCI, V120, P63, DOI 10.1254/jphs.12R09CP
   Giakoumaki SG, 2007, PSYCHOPHARMACOLOGY, V194, P289, DOI 10.1007/s00213-007-0843-7
   Glenthoj BY, 2006, BIOL PSYCHIAT, V60, P621, DOI 10.1016/j.biopsych.2006.01.010
   Goldmann E, 2011, J TRAUMA STRESS, V24, P747, DOI 10.1002/jts.20705
   Gurevich EV, 1999, NEUROPSYCHOPHARMACOL, V20, P60, DOI 10.1016/S0893-133X(98)00066-9
   Halberstadt AL, 2009, NEUROBIOL LEARN MEM, V92, P243, DOI 10.1016/j.nlm.2008.05.015
   Heidbreder CA, 2005, BRAIN RES REV, V49, P77, DOI 10.1016/j.brainresrev.2004.12.033
   Hood SD, 2010, J PSYCHOPHARMACOL, V24, P709, DOI 10.1177/0269881108098144
   Huang WH, 2008, AM J MED GENET B, V147B, P1109, DOI 10.1002/ajmg.b.30731
   Ishiguro H, 2000, MOL PSYCHIATR, V5, P433, DOI 10.1038/sj.mp.4000731
   Joyce JN, 2005, DRUG DISCOV TODAY, V10, P917, DOI 10.1016/S1359-6446(05)03491-4
   Kennedy JL, 1995, AM J MED GENET, V60, P558, DOI 10.1002/ajmg.1320600615
   KESSLER RC, 1995, ARCH GEN PSYCHIAT, V52, P1048
   Klimek V, 2002, BIOL PSYCHIAT, V52, P740, DOI 10.1016/S0006-3223(02)01383-5
   Kobiella A, 2010, HUM BRAIN MAPP, V31, P716, DOI 10.1002/hbm.20900
   Kubany ES, 2000, PSYCHOL ASSESSMENT, V12, P210, DOI 10.1037//1040-3590.12.2.210
   Lane HY, 2008, J CLIN PSYCHOPHARM, V28, P64, DOI 10.1097/jcp.0b013e3181603f5a
   Light KJ, 2006, AM J MED GENET B, V141B, P409, DOI 10.1002/ajmg.b.30308
   Logue MW, 2013, MOL PSYCHIATR, V18, P937, DOI 10.1038/mp.2012.113
   Loiseau F, 2009, EUR NEUROPSYCHOPHARM, V19, P23, DOI 10.1016/j.euroneuro.2008.07.012
   Millan MJ, 2010, INT J NEUROPSYCHOPH, V13, P1035, DOI 10.1017/S1461145710000775
   Munro CA, 2006, BIOL PSYCHIAT, V59, P966, DOI 10.1016/j.biopsych.2006.01.008
   Muthen L. K., 1998, MPLUS USERS GUIDE
   Nunokawa A, 2010, SCHIZOPHR RES, V116, P61, DOI 10.1016/j.schres.2009.10.016
   Patel R, 2012, NEUROSCI BIOBEHAV R, V36, P2130, DOI 10.1016/j.neubiorev.2012.06.003
   PENNARTZ CMA, 1994, PROG NEUROBIOL, V42, P719, DOI 10.1016/0301-0082(94)90025-6
   Pierce RC, 2006, NEUROSCI BIOBEHAV R, V30, P215, DOI 10.1016/j.neubiorev.2005.04.016
   Polak AR, 2012, J AFFECT DISORDERS, V141, P11, DOI 10.1016/j.jad.2012.01.001
   Pritchard JK, 2000, GENETICS, V155, P945
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Retz W, 2003, J NEURAL TRANSM, V110, P561, DOI 10.1007/s00702-002-0805-5
   Schwartz JC, 2000, BRAIN RES REV, V31, P277, DOI 10.1016/S0165-0173(99)00043-0
   SOKOLOFF P, 1990, NATURE, V347, P146, DOI 10.1038/347146a0
   Staal WG, 2012, J AUTISM DEV DISORD, V42, P885, DOI 10.1007/s10803-011-1312-z
   Swerdlow NR, 2009, PSYCHOPHARMACOLOGY, V205, P689, DOI 10.1007/s00213-009-1577-5
   Talkowski ME, 2006, BIOL PSYCHIAT, V60, P570, DOI 10.1016/j.biopsych.2006.04.012
   Uddin M, 2010, P NATL ACAD SCI USA, V107, P9470, DOI 10.1073/pnas.0910794107
   Watson DJG, 2012, NEUROPSYCHOPHARMACOL, V37, P770, DOI 10.1038/npp.2011.254
   Weathers F. W., 1993, 9 ANN C ISTSS SAN AN
   Weathers FW, 1999, PSYCHOL ASSESSMENT, V11, P124, DOI 10.1037/1040-3590.11.2.124
   Wei JX, 2012, ADDICT BEHAV, V37, P622, DOI 10.1016/j.addbeh.2012.01.009
   WEISS JM, 1981, BRAIN RES REV, V3, P167, DOI 10.1016/0165-0173(81)90005-9
   Williams J, 1998, MOL PSYCHIATR, V3, P141, DOI 10.1038/sj.mp.4000376
   Wodarz N, 2003, Arch Womens Ment Health, V6, P225, DOI 10.1007/s00737-003-0011-y
   Wolf EJ, 2013, DEPRESS ANXIETY, V30, P1161, DOI 10.1002/da.22176
   Xi ZX, 2004, PSYCHOPHARMACOLOGY, V176, P57, DOI 10.1007/s00213-004-1858-y
   Zhang FQ, 2011, AM J MED GENET B, V156B, P613, DOI 10.1002/ajmg.b.31203
NR 68
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-9867
EI 1573-6598
J9 J TRAUMA STRESS
JI J. Trauma Stress
PD AUG
PY 2014
VL 27
IS 4
BP 379
EP 387
DI 10.1002/jts.21937
PG 9
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AO2ZQ
UT WOS:000341198000001
PM 25158632
ER

PT J
AU Rouse, CA
   Alber-Morgan, SR
   Cullen, JM
   Sawyer, M
AF Rouse, Christina A.
   Alber-Morgan, Sheila R.
   Cullen, Jennifer M.
   Sawyer, Mary
TI Using Prompt Fading to Teach Self-Questioning to Fifth Graders with LD:
   Effects on Reading Comprehension
SO LEARNING DISABILITIES RESEARCH & PRACTICE
LA English
DT Article
ID LEARNING-DISABILITIES; STUDENTS; STRATEGY; INSTRUCTION; TEXT; KNOWLEDGE;
   AUTISM
AB Students with LD who struggle with reading comprehension can benefit from instruction on how to read strategically. One strategy that has been demonstrated to increase reading comprehension is self-questioning. In this study, two fifth graders with LD were taught to self-generate questions using a prompt fading procedure. The participants were provided with expository reading passages with embedded questions. As each participant demonstrated proficiency with answering the embedded questions correctly, the embedded questions were systematically faded and replaced with a prompt for the students to generate their own questions. A multiple baseline across participants design demonstrated that the self-questioning intervention resulted in improvements in reading comprehension for both students. Additionally, the students demonstrated evidence of maintenance and generalization of reading comprehension outcomes.
C1 [Rouse, Christina A.; Alber-Morgan, Sheila R.; Sawyer, Mary] Ohio State Univ, Columbus, OH 43210 USA.
   [Cullen, Jennifer M.] Ball State Univ, Muncie, IN 47306 USA.
RP Alber-Morgan, SR (reprint author), Ohio State Univ, Columbus, OH 43210 USA.
EM Morgan.651@osu.edu
CR Anderson R. C., 1984, HDB READING RES, P251
   Baer D. M., 1999, PLAN GEN
   Benito Y. M., 1993, J RES READ, V16, P20, DOI 10.1111/j.1467-9817.1993.tb00032.x
   Berkeley S, 2011, REM SPEC EDUC, V32, P105, DOI 10.1177/0741932510361261
   CHAN LKS, 1991, J LEARN DISABIL, V24, P427
   Gajria M, 2007, J LEARN DISABIL-US, V40, P210, DOI 10.1177/00222194070400030301
   GAULTNEY JF, 1995, J EXP CHILD PSYCHOL, V59, P142, DOI 10.1006/jecp.1995.1006
   Hagaman J. L., 2010, REM SPEC EDUC, V20, P1
   Hedin L. R., 2011, PREVENTING SCH FAILU, V55, P148
   Jitendra A. K., 1998, READ WRIT Q, V14, P379, DOI DOI 10.1080/1057356980140403
   Jitendra AK, 2000, J SPEC EDUC, V34, P127, DOI 10.1177/002246690003400302
   Johnson L, 1997, J LEARN DISABIL, V30, P80
   Joseph L. M., READING WRI IN PRESS
   Konrad M., 2010, ED TREATMENT CHILDRE, V33, P187
   LANGER JA, 1984, READ RES QUART, V19, P468, DOI 10.2307/747918
   MALONE LD, 1992, EXCEPT CHILDREN, V58, P270
   Manset-Williamson G., 2008, INT J SPECIAL ED, V23, P123
   Mayfield K. H., 2008, J BEHAV ED, V17, P303, DOI DOI 10.1007/S10864-008-9069-Y
   Morton R. C., 1997, J INSTRUCTIONAL PSYC, V24, P3
   National Reading Panel, 2000, NAT I HLTH PUB
   NOLAN TE, 1991, J READING, V35, P132
   Peterson L, 2008, J DEV PHYS DISABIL, V20, P31, DOI 10.1007/s10882-007-9077-1
   Rivera M. O., 2002, ED TREATMENT CHILDRE, V25, P197
   Rosenshine B, 1996, REV EDUC RES, V66, P181, DOI 10.3102/00346543066002181
   Solis M, 2012, J LEARN DISABIL-US, V45, P327, DOI 10.1177/0022219411402691
   Soluaga D, 2008, RES AUTISM SPECT DIS, V2, P753, DOI 10.1016/j.rasd.2008.03.005
   Taylor L. K., 2002, J BEHAV ED, V11, P69, DOI 10.1023/A:1015409508939
   WONG BYL, 1985, REV EDUC RES, V55, P227, DOI 10.3102/00346543055002227
NR 28
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0938-8982
EI 1540-5826
J9 LEARN DISABIL RES PR
PD AUG
PY 2014
VL 29
IS 3
BP 117
EP 125
DI 10.1111/ldrp.12036
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AN6CB
UT WOS:000340680200006
ER

PT J
AU Isshiki, M
   Tanaka, S
   Kuriu, T
   Tabuchi, K
   Takumi, T
   Okabe, S
AF Isshiki, Masaaki
   Tanaka, Shinji
   Kuriu, Toshihiko
   Tabuchi, Katsuhiko
   Takumi, Toru
   Okabe, Shigeo
TI Enhanced synapse remodelling as a common phenotype in mouse models of
   autism
SO NATURE COMMUNICATIONS
LA English
DT Article
ID FRAGILE-X MICE; LONG-TERM; DENDRITIC SPINES; SOMATOSENSORY CORTEX;
   CRANIAL WINDOW; THALAMOCORTICAL SYNAPSES; POSTSYNAPTIC DENSITY;
   INHIBITORY SYNAPSES; PYRAMIDAL NEURONS; FRONTAL-CORTEX
AB Developmental deficits in neuronal connectivity are considered to be present in patients with autism spectrum disorders (ASDs). Here we examine this possibility by using in vivo spine imaging in the early postnatal cortex of ASD mouse models. Spines are classified by the presence of either the excitatory postsynaptic marker PSD-95 or the inhibitory postsynaptic marker gephyrin. ASD mouse models show consistent upregulation in the dynamics of PSD-95-positive spines, which may subsequently contribute to stable synaptic connectivity. In contrast, spines receiving inputs from the thalamus, detected by the presence of gephyrin clusters, are larger, highly stable and unaffected in ASD mouse models. Importantly, two distinct mouse models, human 15q11-13 duplication and neuroligin-3 R451C point mutation, show highly similar phenotypes in spine dynamics. This selective impairment in dynamics of PSD-95-positive spines receiving intracortical projections may be a core component of early pathological changes and be a potential target of early intervention.
C1 [Isshiki, Masaaki; Tanaka, Shinji; Okabe, Shigeo] Univ Tokyo, Grad Sch Med, Dept Cellular Neurobiol, Bunkyo Ku, Tokyo 1130033, Japan.
   [Kuriu, Toshihiko] Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Dept Neurophysiol, Tokushima, Kagawa 7692193, Japan.
   [Tabuchi, Katsuhiko] Shinshu Univ, Dept Mol & Cellular Physiol, Sch Med, Matsumoto, Nagano 3908621, Japan.
   [Tabuchi, Katsuhiko] Japan Sci & Technol Agcy JST, PRESTO, Kawaguchi, Saitama 3320012, Japan.
   [Takumi, Toru] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan.
   [Takumi, Toru] Japan Sci & Technol Agcy JST, CREST, Kawaguchi, Saitama 3320012, Japan.
RP Okabe, S (reprint author), Univ Tokyo, Grad Sch Med, Dept Cellular Neurobiol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM okabe@m.u-tokyo.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [21220008, 25117006, 26250014]; Global COE Program; Takeda Science
   Foundation [11J05614]; Naito Memorial Foundation
FX We thank Taisuke Mizuguchi and Noriyuki Hayashi for data analysis, Satoe
   Ebihara for technical support, and Dr Shigeo Takamori for providing
   VGluT1 antibody. The BTBR T + tf mouse strain (RBRC 01206) was provided
   by RIKEN BRC through the National Bio-Resource Project of the MEXT,
   Japan. This work was supported by Grants-in-Aid for Scientific Research
   (21220008, 25117006 and 26250014 to S.O.), 'Development of biomarker
   candidates for social behavior' study conducted under the Strategic
   Research Program for Brain Sciences by the Ministry of Education,
   Culture, Sports, Science and Technology of Japan (S.O.), Global COE
   Program (Integrative Life Science Based on the Study of Biosignaling
   Mechanisms to S.O.), Grant-in-Aid for JSPS Fellows (11J05614 to M.I.),
   Takeda Science Foundation (S.O.) and Naito Memorial Foundation (S.O.).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Ashby MC, 2011, NEURON, V70, P510, DOI 10.1016/j.neuron.2011.02.057
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
   Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159
   Bisler S, 2002, J CHEM NEUROANAT, V23, P187, DOI 10.1016/S0891-0618(01)00155-7
   Budreck EC, 2007, EUR J NEUROSCI, V26, P1738, DOI 10.1111/j.1460-9568.2007.05842.x
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Chen JL, 2012, NEURON, V74, P361, DOI 10.1016/j.neuron.2012.02.030
   Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   CRAIR MC, 1995, NATURE, V375, P325, DOI 10.1038/375325a0
   Cruz-Martin A, 2010, J NEUROSCI, V30, P7793, DOI 10.1523/JNEUROSCI.0577-10.2010
   DeFelipe J, 1997, CEREB CORTEX, V7, P619, DOI 10.1093/cercor/7.7.619
   Douglas R., 2004, SYNAPTIC ORG BRAIN, P499
   Ebihara T, 2003, J NEUROSCI, V23, P2170
   Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108
   Feldman DE, 2005, SCIENCE, V310, P810, DOI 10.1126/science.1115807
   Feldman DE, 1999, J NEUROBIOL, V41, P92, DOI 10.1002/(SICI)1097-4695(199910)41:1<92::AID-NEU12>3.0.CO;2-U
   Fox K, 2002, NEUROSCIENCE, V111, P799, DOI 10.1016/S0306-4522(02)00027-1
   Geschwind DH, 2008, CELL, V135, P391, DOI 10.1016/j.cell.2008.10.016
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Goncalves JT, 2013, NAT NEUROSCI, V16, P903, DOI 10.1038/nn.3415
   Goorden SMI, 2007, ANN NEUROL, V62, P648, DOI 10.1002/ana.21317
   Gray NW, 2006, PLOS BIOL, V4, P2065, DOI 10.1371/journal.pbio.0040370
   Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
   Han S, 2012, NATURE, V489, P385, DOI 10.1038/nature11356
   Hill TC, 2013, J NEUROSCI, V33, P678, DOI 10.1523/JNEUROSCI.1404-12.2013
   Holtmaat A, 2009, NAT PROTOC, V4, P1128, DOI 10.1038/nprot.2009.89
   Holtmaat A, 2006, NATURE, V441, P979, DOI 10.1038/nature04783
   Kondo S, 2011, MOL BRAIN, V4, DOI 10.1186/1756-6606-4-27
   Kubota Y, 2007, J NEUROSCI, V27, P1139, DOI 10.1523/JNEUROSCI.3846-06.2007
   Kuriu T, 2012, MOL CELL NEUROSCI, V49, P184, DOI 10.1016/j.mcn.2011.11.002
   Lang M, 2013, HUM MOL GENET, V22, P358, DOI 10.1093/hmg/dds433
   LU SM, 1993, SOMATOSENS MOT RES, V10, P1, DOI 10.3109/08990229309028819
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
   MILLER M, 1981, J NEUROCYTOL, V10, P859, DOI 10.1007/BF01262658
   Mineur YS, 2006, BEHAV BRAIN RES, V168, P172, DOI 10.1016/j.bbr.2005.11.004
   Mitchell BD, 2005, J COMP NEUROL, V482, P17, DOI 10.1002/one.20428
   Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
   Niwa M, 2010, NEURON, V65, P480, DOI 10.1016/j.neuron.2010.01.019
   Okabe S, 1999, NAT NEUROSCI, V2, P804, DOI 10.1038/12175
   Okabe S, 2001, J NEUROSCI, V21, P6105
   Pan F, 2010, P NATL ACAD SCI USA, V107, P17768, DOI 10.1073/pnas.1012496107
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Penzes P, 2011, NAT NEUROSCI, V14, P285, DOI 10.1038/nn.2741
   Qiu SF, 2011, J NEUROSCI, V31, P5855, DOI 10.1523/JNEUROSCI.6569-10.2011
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Sato A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2295
   Spruston N, 2008, NAT REV NEUROSCI, V9, P206, DOI 10.1038/nrn2286
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Tabata H, 2001, NEUROSCIENCE, V103, P865, DOI 10.1016/S0306-4522(01)00016-1
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Takamori S, 2000, NATURE, V407, P189
   Tennant KA, 2011, CEREB CORTEX, V21, P865, DOI 10.1093/cercor/bhq159
   Van De Werd HJJM, 2010, BRAIN STRUCT FUNCT, V214, P339, DOI 10.1007/s00429-010-0247-z
   Xu HT, 2007, NAT NEUROSCI, V10, P549, DOI 10.1038/nn1883
   Yang G, 2010, NAT PROTOC, V5, P201, DOI 10.1038/nprot.2009.222
   Yasumatsu N, 2008, J NEUROSCI, V28, P13592, DOI 10.1523/JNEUROSCI.0603-08.2008
   Yu CX, 2006, PLOS BIOL, V4, P819, DOI 10.1371/journal.pbio.0040124
   Yuste R, 2004, NAT REV NEUROSCI, V5, P24, DOI 10.1038/nrn1300
   Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
   Zuo Y, 2005, NATURE, V436, P261, DOI 10.1038/nature03715
   Zuo Y, 2005, NEURON, V46, P181, DOI 10.1016/j.neuron.2005.04.001
NR 68
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD AUG
PY 2014
VL 5
AR 4742
DI 10.1038/ncomms5742
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO1OC
UT WOS:000341081500001
PM 25144834
ER

PT J
AU Muller, M
   Can, K
AF Mueller, Michael
   Can, Karolina
TI Aberrant redox homoeostasis and mitochondrial dysfunction in Rett
   syndrome
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article
DE antioxidant; autism spectrum disorder; mitochondrial disease; oxidative
   stress; reactive oxygen species (ROS); redox imaging
ID MOUSE MODEL; OXIDATIVE STRESS; CARBOHYDRATE-METABOLISM; MECP2; BRAIN;
   ABNORMALITIES; NEURONS; EXPRESSION; MUTATION; DISEASE
AB RTT (Rett syndrome) is a severe progressive neurodevelopmental disorder with a monogenetic cause, but complex and multifaceted clinical appearance. Compelling evidence suggests that mitochondrial alterations and aberrant redox homoeostasis result in oxidative challenge. Yet, compared with other severe neuropathologies, RTT is not associated with marked neurodegeneration, but rather a chemical imbalance and miscommunication of neuronal elements. Different pharmacotherapies mediate partial improvement of conditions in RTT, and also antioxidants or compounds improving mitochondrial function may be of potential merit. In the present paper, we summarize findings from patients and transgenic mice that point towards the nature of RTT as a mitochondrial disease. Also, open questions are addressed that require clarification to fully understand and successfully target the associated cellular redox imbalance.
C1 [Mueller, Michael; Can, Karolina] Univ Gottingen, Inst Neuro & Sinnesphysiol, Zentrum Physiol & Pathophysiol,Univ Med, Ctr Nanoscale Microscopy & Mol Physiol Brain CNMP, D-37073 Gottingen, Germany.
RP Muller, M (reprint author), Univ Gottingen, Inst Neuro & Sinnesphysiol, Zentrum Physiol & Pathophysiol,Univ Med, Ctr Nanoscale Microscopy & Mol Physiol Brain CNMP, Humboldtallee 23, D-37073 Gottingen, Germany.
EM mmuelle7@gwdg.de
RI Muller, Michael/F-7222-2010
FU Deutsche Forschungsgemeinschaft (Center for Nanoscale Microscopy and
   Molecular Physiology of the Brain, CNMPB); International Rett Syndrome
   Foundation (IRSF) [2817]
FX Our research was funded by the Deutsche Forschungsgemeinschaft (Center
   for Nanoscale Microscopy and Molecular Physiology of the Brain, CNMPB)
   and the International Rett Syndrome Foundation (IRSF) [grant number
   2817].
CR Amir RE, 1999, NAT GENET, V23, P185
   ARMSTRONG D, 1995, J NEUROPATH EXP NEUR, V54, P195, DOI 10.1097/00005072-199503000-00006
   Belichenko PV, 2009, J COMP NEUROL, V514, P240, DOI 10.1002/cne.22009
   BOVERIS A, 1973, BIOCHEM J, V134, P707
   Calfa G, 2011, EXP BIOL MED, V236, P3, DOI 10.1258/ebm.2010.010261
   Chahrour M, 2008, SCIENCE, V320, P1224, DOI 10.1126/science.1153252
   Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
   Christodoulou J., 2010, BMC NEUROSCI, V11, P53
   CLARKE A, 1990, BRAIN DEV-JPN, V12, P119
   COKER SB, 1991, J CHILD NEUROL, V6, P164
   CORNFORD ME, 1994, J CHILD NEUROL, V9, P424
   De Felice C, 2012, ANN NY ACAD SCI, V1259, P121, DOI 10.1111/j.1749-6632.2012.06611.x
   De Felice C, 2009, FREE RADICAL BIO MED, V47, P440, DOI 10.1016/j.freeradbiomed.2009.05.016
   De Felice C, 2012, GENES NUTR, V7, P447, DOI 10.1007/s12263-012-0285-7
   DOTTI MT, 1993, BRAIN DEV-JPN, V15, P103, DOI 10.1016/0387-7604(93)90045-A
   EEGOLOFSSON O, 1990, J CHILD NEUROL, V5, P210
   Fischer M., 2009, J NEUROPHYSIOL, V101, P1016
   Formichi P, 1998, J NEUROL SCI, V156, P227, DOI 10.1016/S0022-510X(98)00035-5
   Funke F, 2011, NEUROIMAGE, V54, P2590, DOI 10.1016/j.neuroimage.2010.11.031
   Grosser E, 2012, NEUROBIOL DIS, V48, P102, DOI 10.1016/j.nbd.2012.06.007
   Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Guzman JN, 2010, NATURE, V468, P696, DOI 10.1038/nature09536
   HAAS RH, 1995, NEUROPEDIATRICS, V26, P90, DOI 10.1055/s-2007-979734
   HAAS RH, 1995, NEUROPEDIATRICS, V26, P95, DOI 10.1055/s-2007-979735
   Hagberg B, 2001, BRAIN DEV-JPN, V23, pS28, DOI 10.1016/S0387-7604(01)00331-X
   HAGBERG B, 1983, ANN NEUROL, V14, P471, DOI 10.1002/ana.410140412
   Hanson GT, 2004, J BIOL CHEM, V279, P13044, DOI 10.1074/jbc.M312846200
   Jane O.A., 2014, FRONT CELL NEUROSCI, V8, P56
   Jian L, 2005, EUR J HUM GENET, V13, P1235, DOI 10.1038/sj.ejhg.5201479
   Julu POO, 2001, ARCH DIS CHILD, V85, P29, DOI 10.1136/adc.85.1.29
   Jung BP, 2003, J NEUROBIOL, V55, P86, DOI 10.1002/neu.10201
   Kerr AM, 1997, EUR CHILD ADOLES PSY, V6, P71
   Kriaucionis S, 2006, MOL CELL BIOL, V26, P5033, DOI 10.1128/MCB.01665-05
   Li Y, 2013, CELL STEM CELL, V13, P446, DOI 10.1016/j.stem.2013.09.001
   MATSUISHI T, 1994, J CHILD NEUROL, V9, P26
   Ostergaard H, 2001, EMBO J, V20, P5853, DOI 10.1093/emboj/20.21.5853
   Pecorelli A., 2013, MEDIATORS INFLAMM, V2013
   PRYOR WA, 1986, ANNU REV PHYSIOL, V48, P657
   Rett A, 1966, Wien Med Wochenschr, V116, P723
   Saywell Véronique, 2006, Biochem Biophys Res Commun, V340, P776, DOI 10.1016/j.bbrc.2005.12.080
   Sierra C, 2001, BRAIN DEV-JPN, V23, pS236, DOI 10.1016/S0387-7604(01)00369-2
   SOFIC E, 1987, BRAIN DEV-JPN, V9, P529
   Steffenburg U, 2001, ACTA PAEDIATR, V90, P34
   Stettner GM, 2008, ADV EXP MED BIOL, V605, P503
   Panighini A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064863
   Toloe J, 2014, MOL CELL NEUROSCI, V59, P47, DOI 10.1016/j.mcn.2013.12.008
   Villemagne PM, 2002, PEDIATR NEUROL, V27, P117, DOI 10.1016/S0887-8994(02)00399-5
   Weerapana E, 2010, NATURE, V468, P790, DOI 10.1038/nature09472
   Young JI, 2004, AM J HUM GENET, V74, P511, DOI 10.1086/382228
NR 50
TC 0
Z9 0
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0300-5127
EI 1470-8752
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD AUG
PY 2014
VL 42
BP 959
EP 964
DI 10.1042/BST20140071
PN 4
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AN1FX
UT WOS:000340329200039
PM 25109986
ER

PT J
AU El Marroun, H
   White, TJH
   van der Knaap, NJF
   Homberg, JR
   Fernandez, G
   Schoemaker, NK
   Jaddoe, VWV
   Hofman, A
   Verhulst, FC
   Hudziak, JJ
   Stricker, BHC
   Tiemeier, H
AF El Marroun, Hanan
   White, Tonya J. H.
   van der Knaap, Noortje J. F.
   Homberg, Judith R.
   Fernandez, Guilen
   Schoemaker, Nikita K.
   Jaddoe, Vincent W. V.
   Hofman, Albert
   Verhulst, Frank C.
   Hudziak, James J.
   Stricker, Bruno H. C.
   Tiemeier, Henning
TI Prenatal exposure to selective serotonin reuptake inhibitors and social
   responsiveness symptoms of autism: population-based study of young
   children
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID ANTIDEPRESSANT EXPOSURE; FETAL-GROWTH; IN-UTERO; MATERNAL DEPRESSION;
   SPECTRUM DISORDERS; BEHAVIOR CHECKLIST; NEONATAL OUTCOMES; STATISTICS
   NOTES; BIRTH OUTCOMES; PREGNANT-WOMEN
AB Background Selective serotonin reuptake inhibitors (SSRIs) are considered safe and are frequently used during pregnancy. However, two case-control studies suggested an association between prenatal SSRI exposure with childhood autism.
   Aims To prospectively determine whether intra-uterine SSSRI exposure is associated with childhood autistic symptoms in a population-based study.
   Method A total of 376 children prenatally exposed to maternal depressive symptoms (no SSRI exposure), 69 children prenatally exposed to SSRIs and 5531 unexposed children were included. Child pervasive developmental and affective problems were assessed by parental report with the Child Behavior Checklist at ages 1.5, 3 and 6. At age 6, we assessed autistic traits using the Social Responsiveness Scale (n = 4264).
   Results Prenatal exposure to maternal depressive symptoms without SSRIs was related to both pervasive developmental (odds ratio (OR) = 1.44, 95% CI 1.07-1.93) and affective problems (OR = 1.44, 95% CI 1.15-1.81). Compared with unexposed children, those prenatally exposed to SSRIs also were at higher risk for developing pervasive developmental problems (OR = 1.91, 95% CI 1.13-3.47), but not for affective problems. Children prenatally exposed to SSRIs also had more autistic traits (B=0.15, 95% CI 0.08-0.22) compared with those exposed to depressive symptoms only.
   Conclusions Our results suggest an association between prenatal SSRI exposure and autistic traits in children. Prenatal depressive symptoms without SSRI use were also associated with autistic traits, albeit this was weaker and less specific. Longterm drug safety trials are needed before evidence-based recommendations are possible.
C1 [El Marroun, Hanan; White, Tonya J. H.; Schoemaker, Nikita K.] Sophia Childrens Univ Hosp, Dept Child & Adolescent Psychiat, NL-3000 CB Rotterdam, Netherlands.
   [El Marroun, Hanan; Schoemaker, Nikita K.] Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.
   [White, Tonya J. H.] Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
   [van der Knaap, Noortje J. F.; Homberg, Judith R.; Fernandez, Guilen] Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands.
   [Jaddoe, Vincent W. V.] Erasmus MC, Dept Epidemiol, Generat R Study Grp, Rotterdam, Netherlands.
   [Jaddoe, Vincent W. V.] Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [Hofman, Albert; Stricker, Bruno H. C.] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Verhulst, Frank C.; Hudziak, James J.; Tiemeier, Henning] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat, NL-3000 CB Rotterdam, Netherlands.
   [Hudziak, James J.] Univ Vermont, Coll Med, Deptartment Psychiat, Burlington, VT USA.
   [Stricker, Bruno H. C.] Inspectorate Healthcare, The Hague, Netherlands.
   [Tiemeier, Henning] Sophia Childrens Univ Hosp, Dept Child & Adolescent Psychiat, Dept Epidemiol, NL-3000 CB Rotterdam, Netherlands.
   [Tiemeier, Henning] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
RP Tiemeier, H (reprint author), Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat, NL-3000 CB Rotterdam, Netherlands.
EM h.tiemeier@erasmusmc.nl
RI Fernandez, Guillen/B-3771-2009; Homberg, Judith/D-2473-2010
OI Fernandez, Guillen/0000-0002-5522-0604; 
FU Sophia Children's Hospital Fund [SSWO-616]; Erasmus Medical Centre;
   Netherlands Organization for Health Research and Development (Zon MW
   Geestkracht Program) [10.000.1003]; Netherlands Organization for Health
   Research and Development (ZonMw TOP) [40-00812-98-11021]; Netherlands
   Organization for Health Research and Development (NWO Brain & Cognition
   Program) [433-09-311]; Netherlands Organization for Health Research and
   Development (VIDI) [017.106.370]
FX The Sophia Children's Hospital Fund (SSWO-616) supported this work
   financially. The first phase of the Generation R Study was made possible
   by financial support from the Erasmus Medical Centre and The Netherlands
   Organization for Health Research and Development (Zon MW Geestkracht
   Program 10.000.1003 & ZonMw TOP 40-00812-98-11021, NWO Brain & Cognition
   Program Grant 433-09-311 and VIDI Grant 017.106.370)
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
   ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Andrews G, 1998, SOC PSYCH PSYCH EPID, V33, P80, DOI 10.1007/s001270050026
   Ansorge MS, 2008, J NEUROSCI, V28, P199, DOI 10.1523/JNEUROSCI.3973-07.2008
   Austin MP, 2006, PSYCHOL MED, V36, P1663, DOI 10.1017/S003329170600835X
   Bakker MK, 2008, BRIT J CLIN PHARMACO, V65, P600, DOI 10.1111/j.1365-2125.2007.03048.x
   Bakker R, 2011, NICOTINE TOB RES, V13, P1250, DOI 10.1093/ntr/ntr117
   Barbey JT, 1998, J CLIN PSYCHIAT, V59, P42
   Casper RC, 2003, J PEDIATR-US, V142, P402, DOI 10.1067/mpd.203.139
   Chambers CD, 1996, NEW ENGL J MED, V335, P1010, DOI 10.1056/NEJM199610033351402
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   COX JL, 1987, BRIT J PSYCHIAT, V150, P782, DOI 10.1192/bjp.150.6.782
   Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73
   de Beurs E, 2004, BRIEF SYMPTOM INVENT
   DEROGATIS LR, 1983, PSYCHOL MED, V13, P595
   El Marroun H, 2012, ARCH GEN PSYCHIAT, V69, P706, DOI 10.1001/archgenpsychiatry.2011.2333
   Gaspar P, 2003, NAT REV NEUROSCI, V4, P1002, DOI 10.1038/nrn1256
   Greenland S, 1995, AM J EPIDEMIOL, V142, P1255
   Hirschfeld RMA, 2001, BRIT J PSYCHIAT, V179, pS4, DOI 10.1192/bjp.179.42.s4
   Ivanova MY, 2010, J AM ACAD CHILD PSY, V49, P1215, DOI 10.1016/j.jaac.2010.08.019
   Jaddoe VWV, 2010, EUR J EPIDEMIOL, V25, P823, DOI 10.1007/s10654-010-9516-7
   Jaddoe VWV, 2007, AM J EPIDEMIOL, V165, P1207, DOI 10.1093/aje/kwm014
   Levison-Castiel R, 2006, ARCH PEDIAT ADOL MED, V160, P173, DOI 10.1001/archpedi.160.2.173
   Lund N, 2009, ARCH PEDIAT ADOL MED, V163, P949, DOI 10.1001/archpediatrics.2009.164
   Maciag D, 2006, NEUROPSYCHOPHARMACOL, V31, P47, DOI 10.1038/sj.npp.1300823
   Matthews JNS, 1996, BRIT MED J, V313, P862
   Matthews JNS, 1996, BRIT MED J, V313, P808
   MICKEY RM, 1989, AM J EPIDEMIOL, V129, P125
   Misri S, 2006, AM J PSYCHIAT, V163, P1026, DOI 10.1176/appi.ajp.163.6.1026
   Mulder EJH, 2011, NEUROPSYCHOPHARMACOL, V36, P1961, DOI 10.1038/npp.2011.67
   Muratori F, 2011, EPIDEMIOL PSYCH SCI, V20, P329, DOI 10.1017/S204579601100045X
   Nakamura BJ, 2009, J PSYCHOPATHOL BEHAV, V31, P178, DOI 10.1007/s10862-008-9119-8
   Nulman I, 2002, AM J PSYCHIAT, V159, P1889, DOI 10.1176/appi.ajp.159.11.1889
   Oberlander TF, 2006, ARCH GEN PSYCHIAT, V63, P898, DOI 10.1001/archpsyc.63.8.898
   Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x
   Pedersen LH, 2010, PEDIATRICS, V125, pE600, DOI 10.1542/peds.2008-3655
   POP VJ, 1992, J AFFECT DISORDERS, V26, P105, DOI 10.1016/0165-0327(92)90041-4
   Rai D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2059
   Rayburn W F, 2000, J Matern Fetal Med, V9, P136
   Rothman K, 2008, MODERN EPIDEMIOLOGY, V3rd
   Rothman K J, 1990, Epidemiology, V1, P43, DOI 10.1097/00001648-199001000-00010
   Sanz EJ, 2005, LANCET, V365, P482, DOI 10.1016/S0140-6736(05)17865-9
   Schetter CD, 2011, ANNU REV PSYCHOL, V62, P531, DOI 10.1146/annurev.psych.031809.130727
   Sikora DM, 2008, J AUTISM DEV DISORD, V38, P440, DOI 10.1007/s10803-007-0407-z
   Simon GE, 2002, AM J PSYCHIAT, V159, P2055, DOI 10.1176/appi.ajp.159.12.2055
   Simpson KL, 2011, P NATL ACAD SCI USA, V108, P18465, DOI 10.1073/pnas.1109353108
   Statistics Netherlands, 2004, STAND OND 2003
   Statistics Netherlands, 2004, ALL NED 2004
   Talge NM, 2007, J CHILD PSYCHOL PSYC, V48, P245, DOI 10.1111/j.1469-7610.2007.01714.x
   Tick NT, 2007, J AM ACAD CHILD PSY, V46, P1333, DOI 10.1097/chi.0b013e3181337532
   Verburg BO, 2008, ULTRASOUND OBST GYN, V31, P388, DOI 10.1002/uog.5225
   Walter SD, 2001, J CLIN EPIDEMIOL, V54, P1072, DOI 10.1016/S0895-4356(01)00385-7
NR 56
TC 2
Z9 2
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
   ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2014
VL 205
IS 2
BP 95
EP 102
DI 10.1192/bjp.bp.113.127746
PG 8
WC Psychiatry
SC Psychiatry
GA AM7CR
UT WOS:000340022800004
PM 25252317
ER

PT J
AU Feldman, R
   Golan, O
   Hirschler-Guttenberg, Y
   Ostfeld-Etzion, S
   Zagoory-Sharon, O
AF Feldman, Ruth
   Golan, Ofer
   Hirschler-Guttenberg, Yael
   Ostfeld-Etzion, Sharon
   Zagoory-Sharon, Orna
TI Parent child interaction and oxytocin production in pre-schoolers with
   autism spectrum disorder
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID RECEPTOR GENE OXTR; INTRANASAL OXYTOCIN; SOCIAL ENGAGEMENT; ASSOCIATION;
   EXPRESSION; SYNCHRONY; COGNITION; BEHAVIOR
AB Background Autism spectrum disorder (ASD) is associated with genetic risk on the oxytocin,system, suggesting oxytocin involvement in ASD; yet oxytocin functioning in young children with ASD is unknown.
   Aims To assess baseline oxytocin in pre-schoolers with ASD and test whether oxytocin production may be enhanced by parent-child contact.
   Method Forty pre-schoolers with high-functioning ASD were matched with 40. typically developing controls. Two home visits included an identical 45-minute social battery once with the mother and once with the father. Four saliva oxytocin samples were collected from each parent and the child during each visit.
   Results Children with ASD had lower baseline oxytocin. Following 20 mm of parent-child interactions, oxytocin normalised and remained high during social contact. Fifteen. minutes after contact, oxytocin fell to baseline. Oxytocin correlated with parent-child social synchrony in both groups.
   Conclusions Oxytocin dysfunction in ASD is observed in early childhood. The quick improvement in oxytocin production following parent-child contact underscores the malleability of the system and charts future directions for attachment-based behavioural and pharmacological interventions.
C1 [Feldman, Ruth; Golan, Ofer; Hirschler-Guttenberg, Yael; Ostfeld-Etzion, Sharon; Zagoory-Sharon, Orna] Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
   [Feldman, Ruth; Golan, Ofer; Hirschler-Guttenberg, Yael; Ostfeld-Etzion, Sharon; Zagoory-Sharon, Orna] Bar Ilan Univ, Gonda Brain Sci Ctr, IL-52900 Ramat Gan, Israel.
RP Feldman, R (reprint author), Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
EM feldman@mail.biu.ac.il
FU German-Israeli Science Foundation [1114-101.4/2010]; Irving B. Harris
   Foundation; US-Israeli Bi-National Science Foundation; Association for
   Children at Risk, Israel
FX The study was supported by the German-Israeli Science Foundation
   (1114-101.4/2010), the Irving B. Harris Foundation, the US-Israeli
   Bi-National Science Foundation, and the Association for Children at
   Risk, Israel.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
   Domes G, 2013, BIOL PSYCHIAT, V74, P164, DOI 10.1016/j.biopsych.2013.02.007
   Feldman R, 2012, MONOGR SOC RES CHILD, V77, P42, DOI 10.1111/j.1540-5834.2011.00660.x
   Feldman R, 2010, HORM BEHAV, V58, P696
   Feldman R, 2007, EMOTION, V7, P601, DOI 10.1037/1528-3542.7.3.601
   Feldman R, 2013, NEUROPSYCHOPHARMACOL, V38, P1154, DOI 10.1038/npp.2013.22
   Feldman R, 2012, BIOL PSYCHIAT, V72, P175, DOI 10.1016/j.biopsych.2011.12.025
   Feldman R, 2010, PSYCHONEUROENDOCRINO, V35, P1133, DOI 10.1016/j.psyneuen.2010.01.013
   Gordon I, 2013, P NATL ACAD SCI USA, V110, P20953, DOI 10.1073/pnas.1312857110
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Green LA, 2001, BIOL PSYCHIAT, V50, P609, DOI 10.1016/S0006-3223(01)01139-8
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Hofer MA., ATTACHMENT THEORY SO, P203
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
   Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
   Miller M, 2013, AUTISM RES, V6, P91, DOI 10.1002/aur.1270
   Oppenheim D, 2012, ATTACH HUM DEV, V14, P567, DOI 10.1080/14616734.2012.727256
   Ross HE, 2009, FRONT NEUROENDOCRIN, V30, P534, DOI 10.1016/j.yfrne.2009.05.004
   Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
   Thorndike RL, 1986, STANFORD BINET INTEL
   van der Veen R, 2012, FRONT NEUROSCI, V6, P174
   Weisman O, 2012, PSYCHONEUROENDOCRINO, V37, P1582, DOI 10.1016/j.psyneuen.2012.02.014
   Weisman O, 2012, BIOL PSYCHIAT, V72, P982, DOI 10.1016/j.biopsych.2012.06.011
   White-Traut R, 2009, DEV PSYCHOBIOL, V51, P367, DOI 10.1002/dev.20376
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x
NR 28
TC 1
Z9 1
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
   ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2014
VL 205
IS 2
BP 107
EP 112
DI 10.1192/bjp.bp.113.137513
PG 6
WC Psychiatry
SC Psychiatry
GA AM7CR
UT WOS:000340022800007
PM 24855128
ER

PT J
AU Camarena, V
   Cao, L
   Abad, C
   Abrams, A
   Toledo, Y
   Araki, K
   Araki, M
   Walz, K
   Young, JI
AF Camarena, Vladimir
   Cao, Lei
   Abad, Clemer
   Abrams, Alexander
   Toledo, Yaima
   Araki, Kimi
   Araki, Masatake
   Walz, Katherina
   Young, Juan I.
TI Disruption of Mbd5 in mice causes neuronal functional deficits and
   neurobehavioral abnormalities consistent with 2q23.1 microdeletion
   syndrome
SO EMBO MOLECULAR MEDICINE
LA English
DT Article
DE autistic disorder; intellectual disability; MBD5; mouse model
ID IMPAIRED SOCIAL-INTERACTION; AUTISM SPECTRUM DISORDER; INTELLECTUAL
   DISABILITY; DEVELOPMENTAL DELAY; BINDING DOMAIN; MOUSE MODELS; GENE;
   FEATURES; MUTATIONS; IDENTIFICATION
AB 2q23.1 microdeletion syndrome is characterized by intellectual disability, motor delay, autistic-like behaviors, and a distinctive craniofacial phenotype. All patients carry a partial or total deletion of methyl-CpG-binding domain protein 5 (MBD5), suggesting that haploinsufficiency of this gene is responsible for the phenotype. To confirm this hypothesis and to examine the role of MBD5 in vivo, we have generated and characterized an Mbd5 gene-trap mouse model. Our study indicates that the Mbd5(+/GT) mouse model recapitulates most of the hallmark phenotypes observed in 2q23.1 deletion carriers including abnormal social behavior, cognitive impairment, and motor and craniofacial abnormalities. In addition, neuronal cultures uncovered a deficiency in neurite outgrowth. These findings support a causal role of MBD5 in 2q23.1 microdeletion syndrome and suggest a role for MBD5 in neuronal processes. The Mbd5(+/GT) mouse model will advance our understanding of the abnormal brain development underlying the emergence of 2q23.1 deletion-associated behavioral and cognitive symptoms.
C1 [Camarena, Vladimir; Cao, Lei; Abrams, Alexander; Toledo, Yaima; Walz, Katherina; Young, Juan I.] Univ Miami, Dept Human Genet, John T Macdonald Fdn, Miami, FL USA.
   [Abad, Clemer; Walz, Katherina; Young, Juan I.] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA.
   [Araki, Kimi; Araki, Masatake] Kumamoto Univ, Inst Resource Dev & Anal, Kumamoto, Japan.
RP Young, JI (reprint author), Univ Miami, Dept Human Genet, John T Macdonald Fdn, Miami, FL USA.
EM jyoung3@med.miami.edu
FU Le Jerome Lejeune Foundation
FX We thank Alison Castle for technical assistance. This study was
   supported in part by Le Jerome Lejeune Foundation.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Amir RE, 1999, NAT GENET, V23, P185
   Araki M, 2014, DEV GROWTH DIFFER, V56, P161, DOI 10.1111/dgd.12116
   Bestor TH, 2004, COLD SPRING HARB SYM, V69, P381, DOI 10.1101/sqb.2004.69.381
   Bogdanovic O, 2009, CHROMOSOMA, V118, P549, DOI 10.1007/s00412-009-0221-9
   Bonnet C, 2013, EUR J HUM GENET, V21, P1457, DOI 10.1038/ejhg.2013.22
   Chung BHY, 2012, EUR J HUM GENET, V20, P398, DOI 10.1038/ejhg.2011.199
   Chung BHY, 2011, AM J MED GENET A, V155A, P424, DOI 10.1002/ajmg.a.33821
   Cukier HN, 2012, AUTISM RES, V5, P385, DOI 10.1002/aur.1251
   Du YR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047358
   Egashira N, 2007, BEHAV BRAIN RES, V178, P123, DOI 10.1016/j.bbr.2006.12.009
   Guernsey DL, 2011, NAT GENET, V43, P360, DOI 10.1038/ng.777
   Hendrich B, 1998, MOL CELL BIOL, V18, P6538
   Jaenisch R, 2003, NAT GENET, V33, P245, DOI 10.1038/ng1089
   Jaillard S, 2009, J MED GENET, V46, P847, DOI 10.1136/jmg.2008.058156
   Johansen JP, 2011, CELL, V147, P509, DOI 10.1016/j.cell.2011.10.009
   Laget S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011982
   Lister R, 2009, NATURE, V462, P315, DOI 10.1038/nature08514
   Maren S, 2013, NAT REV NEUROSCI, V14, P417, DOI 10.1038/nrn3492
   Motobayashi M, 2012, AM J MED GENET A, V158A, P861, DOI 10.1002/ajmg.a.35235
   Mullegama SV, 2014, EUR J HUM GENET, V22, P57, DOI 10.1038/ejhg.2013.67
   Noh GJ, 2012, EUR J MED GENET, V55, P354, DOI 10.1016/j.ejmg.2012.05.003
   PHILLIPS RG, 1992, BEHAV NEUROSCI, V106, P274, DOI 10.1037//0735-7044.106.2.274
   Roloff TC, 2003, BMC GENOMICS, V4, DOI 10.1186/1471-2164-4-1
   Saito M, 2002, J BIOL CHEM, V277, P35434, DOI 10.1074/jbc.M203455200
   Sato A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2295
   Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011
   Taniwaki T, 2005, DEV GROWTH DIFFER, V47, P163
   Tao YL, 2014, BRIT J HAEMATOL, V166, P279, DOI 10.1111/bjh.12863
   Tronson NC, 2012, TRENDS NEUROSCI, V35, P145, DOI 10.1016/j.tins.2011.10.003
   van Bon BWM, 2010, EUR J HUM GENET, V18, P163, DOI 10.1038/ejhg.2009.152
   Wagner EJ, 2012, NAT REV MOL CELL BIO, V13, P115, DOI 10.1038/nrm3274
   Walz K, 2004, HUM MOL GENET, V13, P367, DOI 10.1093/hmg/ddh044
   Williams SR, 2010, EUR J HUM GENET, V18, P436, DOI 10.1038/ejhg.2009.199
   Young JI, 2005, P NATL ACAD SCI USA, V102, P17551, DOI 10.1073/pnas.0507856102
NR 35
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-4676
EI 1757-4684
J9 EMBO MOL MED
JI EMBO Mol. Med.
PD AUG
PY 2014
VL 6
IS 8
BP 1003
EP 1015
DI 10.15252/emmm.201404044
PG 13
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AN2LN
UT WOS:000340416800003
PM 25001218
ER

PT J
AU Busquets-Garcia, A
   Maldonado, R
   Ozaita, A
AF Busquets-Garcia, Arnau
   Maldonado, Rafael
   Ozaita, Andres
TI New insights into the molecular pathophysiology of fragile X syndrome
   and therapeutic perspectives from the animal model
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE Autism; Fragile X syndrome; mGluR5; Mammalian target of rapamycin
   (mTOR); Endocannabinoid system; CB1 cannabinoid receptor; Intellectual
   disability; Anxiety; Epilepsy; Nociception
ID MENTAL-RETARDATION PROTEIN; LONG-TERM POTENTIATION; FMR1 KNOCKOUT MICE;
   GLYCOGEN-SYNTHASE KINASE-3; SELF-INJURIOUS-BEHAVIOR; MOUSE MODEL;
   SYNAPTIC PLASTICITY; NEURODEVELOPMENTAL DISORDERS; ENDOCANNABINOID
   SYSTEM; AUDIOGENIC-SEIZURES
AB Fragile X syndrome is the most common monogenetic form of intellectual disability and is a leading cause of autism. This syndrome is produced by the reduced transcription of the fragile X mental retardation (FMR1) gene, and it is characterized by a range of symptoms heterogeneously expressed in patients such as cognitive impairment, seizure susceptibility, altered pain sensitivity and anxiety. The recent advances in the understanding of the pathophysiological mechanisms involved have opened novel potential therapeutic approaches identified in preclinical rodent models as a necessary preliminary step for the subsequent evaluation in patients. Among those possible therapeutic approaches, the modulation of the metabotropic glutamate receptor signaling or the GABA receptor signaling have focused most of the attention. New findings in the animal models open other possible therapeutic approaches such as the mammalian target of rapamycin signaling pathway or the endocannabinoid system. This review summarizes the emerging data recently obtained in preclinical models of fragile X syndrome supporting these new therapeutic perspectives. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Busquets-Garcia, Arnau; Maldonado, Rafael; Ozaita, Andres] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona 08003, Spain.
RP Ozaita, A (reprint author), Univ Pompeu Fabra, Fac Ciencies Salut & Vida, Lab Neurofarmacol, Parc Recerca Biomed Barcelona, Barcelona 08003, Spain.
EM andres.ozaita@upf.edu
RI Maldonado, Rafael/F-5657-2014
OI Maldonado, Rafael/0000-0002-4359-8773
FU Ministerio de Educacion y Cultura; "Investments for the future"
   Programme IdEx Bordeaux, French National Research Agency
   [ANR-10-IDEX-03-02]; FRAXA Research Foundation; Jerome Lejeune
   Foundation; Ministerio de Ciencia e Innovacion [BFU2012-33500,
   SAF2011-29864]; Instituto de Salud Carlos III [RD06/0001/0001]; PLANE
   (Plan Espanol para el Estimulo de la Economia y el Empleo); Generalitat
   de Catalunya [SGR-2009-00731]; ICREA (Institucio Catalana de Recerca i
   Estudis Avancats) Academia
FX AB-G was recipient of a predoctoral fellowship (Ministerio de Educacion
   y Cultura) and supported by "Investments for the future" Programme IdEx
   Bordeaux (ANR-10-IDEX-03-02, French National Research Agency). Related
   research on the subject was supported by grants from FRAXA Research
   Foundation (A.O.), Jerome Lejeune Foundation (A.O.), Ministerio de
   Ciencia e Innovacion (#BFU2012-33500 to A.O., #SAF2011-29864 to R.M.);
   Instituto de Salud Carlos III (RD06/0001/0001 to R.M.); PLANE (Plan
   Espanol para el Estimulo de la Economia y el Empleo); Generalitat de
   Catalunya (SGR-2009-00731 to R.M.); ICREA (Institucio Catalana de
   Recerca i Estudis Avancats) Academia to R.M.
CR Auerbach BD, 2010, J NEUROPHYSIOL, V104, P1047, DOI 10.1152/jn.00449.2010
   Bailey DB, 2008, AM J MED GENET A, V146A, P2060, DOI 10.1002/ajmg.a.32439
   BAKER, 1994, CELL, V78, P23
   Baker KB, 2010, GENES BRAIN BEHAV, V9, P562, DOI 10.1111/j.1601-183X.2010.00585.x
   Bateup HS, 2013, NEURON, V78, P510, DOI 10.1016/j.neuron.2013.03.017
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Beaulieu JM, 2012, J PSYCHIATR NEUROSCI, V37, P7, DOI 10.1503/jpn.110011
   Berry-Kravis E, 2010, AJIDD-AM J INTELLECT, V115, P461, DOI [10.1352/1944-7558-115.6.461, 10.1352/194475581156461]
   Bhattacharya A, 2012, NEURON, V76, P325, DOI 10.1016/j.neuron.2012.07.022
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Busquets-Garcia A, 2013, NAT MED, V19, P603, DOI 10.1038/nm.3127
   Castillo PE, 2012, NEURON, V76, P70, DOI 10.1016/j.neuron.2012.09.020
   Chuang SC, 2005, J NEUROSCI, V25, P8048, DOI 10.1523/JNEUROSCI.1777-05.2005
   CHUDLEY AE, 1987, J PEDIATR-US, V110, P821, DOI 10.1016/S0022-3476(87)80392-X
   Cornish K, 2008, J INTELL DISABIL RES, V52, P469, DOI 10.1111/j.1365-2788.2008.01056.x
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   DHooge R, 1997, NEUROSCIENCE, V76, P367, DOI 10.1016/S0306-4522(96)00224-2
   D'Hulst C, 2007, TRENDS NEUROSCI, V30, P425, DOI 10.1016/j.tins.2007.06.003
   Dobkin C, 2000, NEUROSCIENCE, V100, P423, DOI 10.1016/S0306-4522(00)00292-X
   Dolan BM, 2013, P NATL ACAD SCI USA, V110, P5671, DOI [10.1073/pnas.1219383110, 10.1073/pnas.1219353110]
   Domercq M, 2004, TRENDS PHARMACOL SCI, V25, P609, DOI 10.1016/j.tips.2004.10.001
   Eichler Sabrina A, 2008, Front Mol Neurosci, V1, P2, DOI 10.3389/neuro.02.002.2008
   Erickson CA, 2013, PSYCHOPHARMACOLOGY, V228, P75, DOI 10.1007/s00213-013-3022-z
   Fisch GS, 2002, J AUTISM DEV DISORD, V32, P107, DOI 10.1023/A:1014888505185
   Franklin AV, 2014, BIOL PSYCHIAT, V75, P198, DOI 10.1016/j.biopsych.2013.08.003
   Fride Ester, 2005, Curr Drug Targets CNS Neurol Disord, V4, P633, DOI 10.2174/156800705774933069
   Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008
   Godfraind JM, 1996, AM J MED GENET, V64, P246
   Gomez-Mancilla B, 2014, EXPERT OPIN INV DRUG, V23, P125, DOI 10.1517/13543784.2014.857400
   Goncalves JT, 2013, NAT NEUROSCI, V16, P903, DOI 10.1038/nn.3415
   Gross C, 2010, J NEUROSCI, V30, P10624, DOI 10.1523/JNEUROSCI.0402-10.2010
   Grossman AW, 2006, BRAIN RES, V1084, P158, DOI 10.1016/j.brainres.2006.02.044
   Guertin DA, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.267pe24
   Hagerman R, 2012, RESULTS PROBL CELL D, V54, P297, DOI 10.1007/978-3-642-21649-7_17
   Hagerman RJ, 2006, J DEV BEHAV PEDIATR, V27, P63, DOI 10.1097/00004703-200602000-00012
   Hayashi ML, 2007, P NATL ACAD SCI USA, V104, P11489, DOI 10.1073/pnas.0705003104
   Hays SA, 2011, J NEUROSCI, V31, P14223, DOI 10.1523/JNEUROSCI.3157-11.2011
   He CX, 2013, NEUROSCIENCE, V251, P120, DOI 10.1016/j.neuroscience.2012.03.049
   Henderson C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004218
   HINTON VJ, 1991, AM J MED GENET, V41, P289, DOI 10.1002/ajmg.1320410306
   Hoeffer CA, 2012, GENES BRAIN BEHAV, V11, P332, DOI 10.1111/j.1601-183X.2012.00768.x
   Hou LF, 2004, J NEUROSCI, V24, P6352, DOI 10.1523/JNEUROSCI.0995-04.2004
   Hu HL, 2008, J NEUROSCI, V28, P7847, DOI 10.1523/JNEUROSCI.1496-08.2008
   Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
   JACQUEMONT S, 2013, PSYCHOPHARMACOLOGY B
   Janusz A, 2013, J NEUROSCI, V33, P18234, DOI 10.1523/JNEUROSCI.2207-13.2013
   Jung KM, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2045
   Kano M, 2009, PHYSIOL REV, V89, P309, DOI 10.1152/physrev.00019.2008
   Kooy RF, 2003, TRENDS GENET, V19, P148
   Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
   Lauterborn JC, 2007, J NEUROSCI, V27, P10685, DOI 10.1523/JNEUROSCI.2624-07.2007
   Lee HY, 2011, NEURON, V72, P630, DOI 10.1016/j.neuron.2011.09.033
   Levenga J, 2010, TRENDS MOL MED, V16, P516, DOI 10.1016/j.molmed.2010.08.005
   Lim CS, 2014, GENE DEV, V28, P273, DOI 10.1101/gad.232470.113
   Liu ZH, 2009, NEUROSCI LETT, V454, P62, DOI 10.1016/j.neulet.2009.02.066
   Long JZ, 2009, NAT CHEM BIOL, V5, P37, DOI 10.1038/nchembio.129
   Lynch MA, 2004, PHYSIOL REV, V84, P87, DOI 10.1152/physrev.00014.2003
   Maccarrone M, 2010, NEUROPSYCHOPHARMACOL, V35, P1500, DOI 10.1038/npp.2010.19
   Mann K, 2008, ALCOHOL CLIN EXP RES, V32, P1105, DOI 10.1111/j.1530-0277.2008.00690.x
   Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
   Marsicano G, 1999, EUR J NEUROSCI, V11, P4213, DOI 10.1046/j.1460-9568.1999.00847.x
   Massey PV, 2007, TRENDS NEUROSCI, V30, P176, DOI 10.1016/j.tins.2007.02.005
   Michalon A, 2014, BIOL PSYCHIAT, V75, P189, DOI 10.1016/j.biopsych.2013.05.038
   Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
   Miller LJ, 1999, AM J MED GENET, V83, P268, DOI 10.1002/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.3.CO;2-B
   Min WW, 2009, NEUROPHARMACOLOGY, V56, P463, DOI 10.1016/j.neuropharm.2008.09.017
   Mineur YS, 2002, HIPPOCAMPUS, V12, P39, DOI 10.1002/hipo.10005
   Musumeci SA, 2000, EPILEPSIA, V41, P19, DOI 10.1111/j.1528-1157.2000.tb01499.x
   Pacey LKK, 2009, MOL PHARMACOL, V76, P18, DOI 10.1124/mol.109.056127
   Paluszkiewicz SM, 2011, J NEUROPHYSIOL, V106, P2264, DOI 10.1152/jn.00421.2011
   Paradee W, 1999, NEUROSCIENCE, V94, P185, DOI 10.1016/S0306-4522(99)00285-7
   Peebles KA, 2012, J INTELL DISABIL RES, V56, P441, DOI 10.1111/j.1365-2788.2011.01484.x
   Penagarikano O, 2007, ANNU REV GENOM HUM G, V8, P109, DOI 10.1146/annurev.genom.8.080706.092249
   Penzes P, 2011, NAT NEUROSCI, V14, P285, DOI 10.1038/nn.2741
   Pfeiffer BE, 2009, NEUROSCIENTIST, V15, P549, DOI 10.1177/1073858409333075
   Price TJ, 2007, J NEUROSCI, V27, P13958, DOI 10.1523/JNEUROSCI.4383-07.2007
   Puighermanal E, 2012, PHILOS T R SOC B, V367, P3254, DOI 10.1098/rstb.2011.0384
   Rogawski MA, 2003, CNS DRUG REV, V9, P275
   Roth BL, 2004, NAT REV DRUG DISCOV, V3, P353, DOI 10.1038/nrd1346
   Santoro MR, 2012, ANNU REV PATHOL-MECH, V7, P219, DOI 10.1146/annurev-pathol-011811-132457
   Shang YZ, 2009, J NEUROCHEM, V111, P635, DOI 10.1111/j.1471-4159.2009.06314.x
   Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
   Spencer CM, 2011, AUTISM RES, V4, P40, DOI 10.1002/aur.168
   Spooren W, 2012, TRENDS PHARMACOL SCI, V33, P669, DOI 10.1016/j.tips.2012.09.004
   Stornetta RL, 2011, NEUROSCIENTIST, V17, P54, DOI 10.1177/1073858410365562
   Symons FJ, 2010, AJIDD-AM J INTELLECT, V115, P473, DOI [10.1352/1944-7558-115.6.473, 10.1352/194475581156473]
   Symons FJ, 2004, MENT RETARD DEV D R, V10, P193, DOI 10.1002/mrdd.20031
   Tang SJ, 2002, PHILOS T ROY SOC B, V357, P521, DOI 10.1098/rstb.2001.0887
   Thomas AM, 2011, BEHAV BRAIN RES, V223, P310, DOI 10.1016/j.bbr.2011.04.049
   Tranfaglia MR, 2011, DEV NEUROSCI-BASEL, V33, P337, DOI 10.1159/000329421
   Troca-Marin JA, 2012, PROG NEUROBIOL, V96, P268, DOI 10.1016/j.pneurobio.2012.01.005
   Van Dam D, 2000, BEHAV BRAIN RES, V117, P127, DOI 10.1016/S0166-4328(00)00296-5
   Varma N, 2001, J NEUROSCI, V21, part. no.
   Ventura R, 2004, BEHAV PHARMACOL, V15, P433, DOI 10.1097/00008877-200409000-00018
   Wang T, 2012, CURR OPIN GENET DEV, V22, P256, DOI 10.1016/j.gde.2012.02.002
   Waung MW, 2008, NEURON, V59, P84, DOI 10.1016/j.neuron.2008.05.014
   Wei HE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036981
   Wilson RI, 2002, SCIENCE, V296, P678, DOI 10.1126/science.1063545
   Wondolowski J, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00223
   Zhang J, 2009, J NEUROPHYSIOL, V101, P2572, DOI 10.1152/jn.90558.2008
   Zhang LH, 2010, J NEUROSCI, V30, P5724, DOI 10.1523/JNEUROSCI.0795-10.2010
   Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 102
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
EI 1878-5875
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD AUG
PY 2014
VL 53
BP 121
EP 126
DI 10.1016/j.biocel.2014.05.004
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AN1KE
UT WOS:000340340400015
PM 24831882
ER

PT J
AU Wei, HG
   Alberts, I
   Li, XH
AF Wei, Hongen
   Alberts, Ian
   Li, Xiaohong
TI The apoptotic perspective of autism
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Autism; Apoptosis; Protein; Signaling pathway; Mechanism
ID PROGRAMMED CELL-DEATH; HEPATOCYTE GROWTH-FACTOR; MET TYROSINE KINASE;
   SPECTRUM DISORDERS; MENTAL-RETARDATION; OXIDATIVE STRESS; C-MET;
   NEURONAL APOPTOSIS; SIGNALING PATHWAY; INFANTILE-AUTISM
AB Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests. The normal brain development during fetal brain development and the first year of life is critical to the behaviors and cognitions in adulthood. Programmed cell death (apoptosis) is an important mechanism that determines the size and shape of the brain and regulates the proper wiring of developing neuronal networks. Pathological activation of apoptotic death pathways under pathological conditions may lead to neuroanatomic abnormalities and possibly to developmental disabilities. It has been demonstrated a possible association between neural cell death and autism. Here, the abnormal apoptosis found in autism from postmortem and animal studies was reviewed and the possible mechanism was discussed. (C) 2014 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Wei, Hongen] Shanxi Med Univ, Shanxi Prov Peoples Hosp, Cent Lab, Taiyuan 030012, Peoples R China.
   [Alberts, Ian] CUNY, LaGuardia CC, Dept Nat Sci, New York, NY 11101 USA.
   [Li, Xiaohong] NY State Inst Basic Res Dev Disabil, Dept Neurochem, New York, NY 10314 USA.
RP Wei, HG (reprint author), Shanxi Med Univ, Shanxi Prov Peoples Hosp, Cent Lab, 29 Shuangta Rd, Taiyuan 030012, Peoples R China.
EM hongenwei@gmail.com
FU National Natural Science Foundation of China [81201061]; Shanxi
   Scholarship Council of China [2013-124]; Natural Science Foundation of
   Shanxi [2013021036-2]
FX This work was supported by grants to H. Wei from the National Natural
   Science Foundation of China (No. 81201061), Shanxi Scholarship Council
   of China (No. 2013-124) and Natural Science Foundation of Shanxi (No.
   2013021036-2).
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Andermarcher E, 1996, DEV GENET, V18, P254, DOI 10.1002/(SICI)1520-6408(1996)18:3<254::AID-DVG6>3.0.CO;2-8
   Araghi-Niknam M, 2003, CELL MOL NEUROBIOL, V23, P945, DOI 10.1023/B:CEMN.0000005322.27203.73
   Baron CA, 2006, HUM MOL GENET, V15, P853, DOI 10.1093/hmg/ddl004
   BAUMAN M, 1985, NEUROLOGY, V35, P866
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bibel M, 2000, GENE DEV, V14, P2919, DOI 10.1101/gad.841400
   Buttarelli F. R., 2006, EUR J NEUROL, V13, P416
   BUTTKE TM, 1994, IMMUNOL TODAY, V15, P7, DOI 10.1016/0167-5699(94)90018-3
   Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
   Cavanaugh JE, 2004, EUR J BIOCHEM, V271, P2056, DOI 10.1111/j.1432-1033.2004.04131.x
   Chen JL, 2014, INT J DEV NEUROSCI, V35, P35, DOI 10.1016/j.ijdevneu.2014.03.006
   Cheng Y, 2013, DEV NEUROSCI-BASEL, V35, P347, DOI 10.1159/000353248
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Culmsee C, 2005, BIOCHEM BIOPH RES CO, V331, P761, DOI 10.1016/j.bbrc.2005.03.149
   Davis S, 2006, GENES BRAIN BEHAV, V5, P61, DOI 10.1111/j.1601-183X.2006.00230.x
   Deiss LP, 1996, EMBO J, V15, P3861
   EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794
   El-Ansary AK, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-74
   El-Ansary AK, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-142
   Erdmann S, 2008, EUR J CELL BIOL, V87, P311, DOI 10.1016/j.ejcb.2008.01.005
   Fatemi SH, 2001, NEUROREPORT, V12, P929, DOI 10.1097/00001756-200104170-00013
   Fatemi SH, 2001, J AUTISM DEV DISORD, V31, P529, DOI 10.1023/A:1013234708757
   Fatemi SH, 2001, SYNAPSE, V42, P281, DOI 10.1002/syn.10002
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Franke TF, 2003, ONCOGENE, V22, P8983, DOI 10.1038/sj.onc.1207115
   Franklin A.E., 2008, AM J BIOCH BIOTECHNO, V4, P146
   Frebel K, 2006, BIOCHEM SOC T, V34, P1287
   Fusek M, 2007, J INTERF CYTOK RES, V27, P191, DOI 10.1089/jir.2006.0105
   Gatto CL, 2011, DEV BIOL, V356, P291, DOI 10.1016/j.ydbio.2011.05.001
   Ghanizadeh A, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-58
   Grunnet LG, 2009, DIABETES, V58, P1807, DOI 10.2337/db08-0178
   Harada M, 2011, J AUTISM DEV DISORD, V41, P447, DOI 10.1007/s10803-010-1065-0
   Hartmann A, 2000, P NATL ACAD SCI USA, V97, P2875, DOI 10.1073/pnas.040556597
   Hong SE, 2000, NAT GENET, V26, P93
   Huang EJ, 2003, ANNU REV BIOCHEM, V72, P609, DOI 10.1146/annurev.biochem.72.121801.161629
   Jarskog LF, 2000, BIOL PSYCHIAT, V48, P641, DOI 10.1016/S0006-3223(00)00988-4
   Jarskog LF, 2005, PROG NEURO-PSYCHOPH, V29, P846, DOI 10.1016/j.pnpbp.2005.03.010
   Jarskog LF, 2004, AM J PSYCHIAT, V161, P109, DOI 10.1176/appi.ajp.161.1.109
   JUNG W, 1994, J CELL BIOL, V126, P485, DOI 10.1083/jcb.126.2.485
   Katoh-Semba R, 2007, INT J DEV NEUROSCI, V25, P367, DOI 10.1016/j.ijdevneu.2007.07.002
   Kemper TL, 2002, MOL PSYCHIATR, V7, pS12, DOI 10.1038/sj.mp.4001165
   Kyrylenko S, 1999, MOL BRAIN RES, V73, P198, DOI 10.1016/S0169-328X(99)00259-4
   Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
   Li X., 2013, BRAIN STRUCT FUNCT, V218, P669
   Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
   Loh Kok Poh, 2006, Current Alzheimer Research, V3, P327
   Mahadik SP, 2001, PROG NEURO-PSYCHOPH, V25, P463, DOI 10.1016/S0278-5846(00)00181-0
   Maina F, 1997, GENE DEV, V11, P3341, DOI 10.1101/gad.11.24.3341
   Malik M, 2011, IMMUNOBIOLOGY, V216, P80, DOI 10.1016/j.imbio.2010.03.001
   MARGOLIS RL, 1994, BIOL PSYCHIAT, V35, P946, DOI 10.1016/0006-3223(94)91241-6
   Masliah E, 1998, J NEUROPATH EXP NEUR, V57, P1041, DOI 10.1097/00005072-199811000-00007
   Miyazaki K, 2004, BRAIN DEV-JPN, V26, P292, DOI 10.1016/S0387-7604(03)00168-2
   Murphy LO, 2006, TRENDS BIOCHEM SCI, V31, P268, DOI 10.1016/j.tibs.2006.03.009
   Nazeer A, 2012, PEDIATR CLIN N AM, V59, P19, DOI 10.1016/j.pcl.2011.10.007
   Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
   Olczak M, 2010, FOLIA NEUROPATHOL, V48, P258
   Organ Shawna Leslie, 2011, Ther Adv Med Oncol, V3, pS7, DOI 10.1177/1758834011422556
   Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x
   Piven J, 1997, AM J PSYCHIAT, V154, P1051
   RITVO ER, 1986, AM J PSYCHIAT, V143, P862
   Rudie JD, 2012, NEURON, V75, P904, DOI 10.1016/j.neuron.2012.07.010
   Sasaki T, 2006, J NEUROSCI RES, V84, P1187, DOI 10.1002/jnr.21036
   Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
   Sheikh AM, 2010, J NEUROSCI RES, V88, P2641, DOI 10.1002/jnr.22416
   Sheikh AM, 2010, NEUROSCIENCE, V165, P363, DOI 10.1016/j.neuroscience.2009.10.035
   Shen Y, 2001, ADV CANCER RES, V82, P55, DOI 10.1016/S0065-230X(01)82002-9
   Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
   Angelidou A, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-48
   Silver WG, 2012, PEDIATR CLIN N AM, V59, P45, DOI 10.1016/j.pcl.2011.10.010
   Siniscalco D, 2012, J AUTISM DEV DISORD, V42, P1403, DOI 10.1007/s10803-011-1373-z
   Song MS, 2012, NAT REV MOL CELL BIO, V13, P283, DOI 10.1038/nrm3330
   SONNENBERG E, 1993, J CELL BIOL, V123, P223, DOI 10.1083/jcb.123.1.223
   Sparks BF, 2002, NEUROLOGY, V59, P184
   Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076
   Takeuchi K, 2013, P NATL ACAD SCI USA, V110, P4738, DOI 10.1073/pnas.1222803110
   Trusolino L, 2010, NAT REV MOL CELL BIO, V11, P834, DOI 10.1038/nrm3012
   Tulasne D, 2004, MOL CELL BIOL, V24, P10328, DOI 10.1128/MCB.24.23.10328-10339.2004
   Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Wei HG, 2011, AM J PATHOL, V179, P66, DOI 10.1016/j.ajpath.2011.03.034
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Wright K, 1999, J BIOL CHEM, V274, P17193, DOI 10.1074/jbc.274.24.17193
   Xiao GH, 2001, P NATL ACAD SCI USA, V98, P247, DOI 10.1073/pnas.011532898
   Yin A., 2014, INT J DEV NEUROSCI
   Yochum CL, 2008, BRAIN RES, V1203, P126, DOI 10.1016/j.brainres.2008.01.055
   Zhang YM, 2006, BMC NEUROSCI, V7, DOI 10.1186/1471-2202-7-49
   Zheng WH, 2004, J NEUROCHEM, V89, P844, DOI 10.1111/j.1471-4159.2004.02350.x
   Zhou J, 2012, CURR OPIN NEUROBIOL, V22, P873, DOI 10.1016/j.conb.2012.05.004
   Zhu Y, 2006, APOPTOSIS, V11, P197, DOI 10.1007/s10495-006-3714-5
NR 91
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD AUG
PY 2014
VL 36
BP 13
EP 18
DI 10.1016/j.ijdevneu.2014.04.004
PG 6
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA AN1JW
UT WOS:000340339600003
PM 24798024
ER

PT J
AU Knoth, IS
   Vannasing, P
   Major, P
   Michaud, JL
   Lippe, S
AF Knoth, Inga Sophia
   Vannasing, Phetsamone
   Major, Philippe
   Michaud, Jacques L.
   Lippe, Sarah
TI Alterations of visual and auditory evoked potentials in fragile X
   syndrome
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Fragile X syndrome; Intellectual disability; Autism; Sensory information
   processing; Auditory evoked potential; Visual evoked potential
ID MENTAL-RETARDATION PROTEIN; ABERRANT BEHAVIOR; CHILDREN; AUTISM;
   INHIBITION; MATURATION; DISORDERS; FIELDS; ADULTS; ALPHA
AB Background: Fragile X Syndrome (FXS) is the most common monogenic form of intellectual disability and one of the few known monogenic causes of autism. It is caused by a trinucleotide repeat expansion in the FMR1 ('Fragile X Mental Retardation 1') gene, which prevents expression of the 'Fragile X Mental Retardation Protein' (FMRP). In FXS, the absence of FMRP leads to altered structural and functional development of the synapse, while preventing activity-based synapse maturation and synaptic pruning, which are essential for normal brain development and cognitive development. Possible impairments in information processing can be non-invasively investigated using electrophysiology.
   Methods: We compared auditory (AEP) and visual (VEP) evoked potentials in twelve adolescents and young adults (10-22 years) affected by FXS to healthy controls matched by chronological age (N = 12) and developmental age of cognitive functioning (N = 9; 5-7 years), using analysis of variance.
   Results: In the visual modality, the N70 and N2 amplitude have been found increased in FXS in comparison. to the chronological, but not the developmental control group at occipital sites, whereas in the auditory modality N1, P2 and N2 amplitude as well as N2 latency have been found increased in FXS, relative to both chronological and developmental control groups at mid-central sites.
   Conclusions: The AEP/VEP profile suggests disruptions in sensory processing specific to FXS that exceed immaturity of physiological activity. In addition, the auditory modality seems to be more affected than the visual modality. Results are discussed in light of possible underlying neuronal mechanisms, including deficits in synaptic pruning and neuronal inhibition that might account for a hyperreactive nervous system in FXS. (C) 2014 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Knoth, Inga Sophia; Vannasing, Phetsamone; Major, Philippe; Michaud, Jacques L.; Lippe, Sarah] Univ Montreal, CHU Ste Justine, Mother & Child Univ Hosp Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Knoth, Inga Sophia; Lippe, Sarah] Univ Montreal, Dept Psychol, Montreal, PQ H3T 1C5, Canada.
   [Knoth, Inga Sophia; Lippe, Sarah] Univ Montreal, Ctr Rech Neuropsychol & Cognit, Montreal, PQ H3T 1C5, Canada.
RP Knoth, IS (reprint author), Univ Montreal, CHU Ste Justine, Mother & Child Univ Hosp Ctr, Res Ctr, 3175 Chemin Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM Inga.Knoth@umontreal.ca
FU Scottish Rite Charitable Foundation of Canada [12112]
FX This research was supported by a Scottish Rite Charitable Foundation of
   Canada grant to Sarah Lippe 12112. We thank Domitille Malfait for
   carrying out the neuropsychological evaluation of most of the patients
   and Patricia Laniel and Maude Joannette for their help in the
   acquisition of EEG data. We thank language editor J. Arthur White for
   significantly revising the manuscript.
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Beauchemin M, 2011, CEREB CORTEX, V21, P1705, DOI 10.1093/cercor/bhq242
   Belmonte MK, 2006, NAT NEUROSCI, V9, P1221, DOI 10.1038/nn1765
   Bennetto L, 2001, NEUROPSYCHOLOGY, V15, P290, DOI 10.1037/0894-4105.15.2.290
   Broyd SJ, 2005, INT J PSYCHOPHYSIOL, V58, P47, DOI 10.1016/j.ijphyscho.2005.03.008
   Castren M, 2003, BRAIN TOPOGR, V15, P165, DOI 10.1023/A:1022606200636
   Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
   Darnell JC, 2013, NAT NEUROSCI, V16, P1530, DOI 10.1038/nn.3379
   Di Russo F, 2002, HUM BRAIN MAPP, V15, P95, DOI 10.1002/hbm.10010
   Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
   Gothelf D, 2008, ANN NEUROL, V63, P40, DOI 10.1002/ana.21243
   Hoeft F, 2008, ARCH GEN PSYCHIAT, V65, P1087, DOI 10.1001/archpsyc.65.9.1087
   Hoeft F, 2010, P NATL ACAD SCI USA, V107, P9335, DOI 10.1073/pnas.1002762107
   Jensen O, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00186
   Karhu J, 1997, NEUROREPORT, V8, P1327, DOI 10.1097/00001756-199704140-00002
   Knoth IS, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00264
   Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
   Lippe S, 2007, CEREB CORTEX, V17, P100, DOI 10.1093/cercor/bhj130
   Lippe S, 2009, NEUROSCIENCE, V164, P1108, DOI 10.1016/j.neuroscience.2009.07.066
   Luck S. J., 2005, INTRO EVENT RELATED
   NAATANEN R, 1987, PSYCHOPHYSIOLOGY, V24, P375, DOI 10.1111/j.1469-8986.1987.tb00311.x
   Pfeiffer BE, 2009, NEUROSCIENTIST, V15, P549, DOI 10.1177/1073858409333075
   Pfeiffer BE, 2007, J NEUROSCI, V27, P3120, DOI 10.1523/JNEUROSCI.0054-07.2007
   Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
   Roid G., 1997, LEITER INT PERFORMAN
   Rojas DC, 2001, NEUROREPORT, V12, P2573, DOI 10.1097/00001756-200108080-00056
   Ropers HH, 2005, NAT REV GENET, V6, P46, DOI 10.1038/nrg1501
   Scherg M., 1990, AUDITORY EVOKED MAGN, P40
   Schneider A, 2009, DEV DISABIL RES REV, V15, P333, DOI 10.1002/ddrr.80
   Shigeto H, 1998, J NEUROL SCI, V156, P186, DOI 10.1016/S0022-510X(98)00026-4
   STCLAIR DM, 1987, BIOL PSYCHIAT, V22, P303, DOI 10.1016/0006-3223(87)90148-X
   TUCKER DM, 1993, ELECTROEN CLIN NEURO, V87, P154, DOI 10.1016/0013-4694(93)90121-B
   Van der Molen MJW, 2013, BIOL PSYCHOL, V92, P216, DOI 10.1016/j.biopsycho.2012.11.013
   Van der Molen MJW, 2012, CLIN NEUROPHYSIOL, V123, P1309, DOI 10.1016/j.clinph.2011.11.039
   Van der Molen MJW, 2012, CLIN NEUROPHYSIOL, V123, P720, DOI 10.1016/j.clinph.2011.08.023
   Van der Molen MJW, 2010, RES DEV DISABIL, V31, P426, DOI 10.1016/j.ridd.2009.10.013
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weiler IJ, 1999, AM J MED GENET, V83, P248, DOI 10.1002/(SICI)1096-8628(19990402)83:4<248::AID-AJMG3>3.0.CO;2-1
NR 40
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD AUG
PY 2014
VL 36
BP 90
EP 97
DI 10.1016/j.ijdevneu.2014.05.003
PG 8
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA AN1JW
UT WOS:000340339600013
PM 24875778
ER

PT J
AU Gringras, P
   Green, D
   Wright, B
   Rush, C
   Sparrowhawk, M
   Pratt, K
   Allgar, V
   Hooke, N
   Moore, D
   Zaiwalla, Z
   Wiggs, L
AF Gringras, Paul
   Green, Dido
   Wright, Barry
   Rush, Carla
   Sparrowhawk, Masako
   Pratt, Karen
   Allgar, Victoria
   Hooke, Naomi
   Moore, Danielle
   Zaiwalla, Zenobia
   Wiggs, Luci
TI Weighted Blankets and Sleep in Autistic Children-A Randomized Controlled
   Trial
SO PEDIATRICS
LA English
DT Article
DE autism spectrum disorder; severe sleep problems; weighted blankets;
   total sleep time; children
ID DISORDERS; MELATONIN
AB OBJECTIVE: To assess the effectiveness of a weighted-blanket intervention in treating severe sleep problems in children with autism spectrum disorder (ASD).
   METHODS: This phase III trial was a randomized, placebo-controlled crossover design. Participants were aged between 5 years and 16 years 10 months, with a confirmed ASD diagnosis and severe sleep problems, refractory to community-based interventions. The interventions were either a commercially available weighted blanket or otherwise identical usual weight blanket (control), introduced at bedtime; each was used for a 2-week period before crossover to the other blanket. Primary outcome was total sleep time (TST) recorded by actigraphy over each 2-week period. Secondary outcomes included actigraphically recorded sleep-onset latency, sleep efficiency, assessments of child behavior, family functioning, and adverse events. Sleep was also measured by using parent-report diaries.
   RESULTS: Seventy-three children were randomized and analysis conducted on 67 children who completed the study. Using objective measures, the weighted blanket, compared with the control blanket, did not increase TST as measured by actigraphy and adjusted for baseline TST. There were no group differences in any other objective or subjective measure of sleep, including behavioral outcomes. On subjective preference measures, parents and children favored the weighted blanket.
   CONCLUSIONS: The use of a weighted blanket did not help children with ASD sleep for a longer period of time, fall asleep significantly faster, or wake less often. However, the weighted blanket was favored by children and parents, and blankets were well tolerated over this period.
C1 [Gringras, Paul; Rush, Carla; Pratt, Karen] St Thomas Hosp, Evelina Childrens Hosp, London SE1 7EH, England.
   [Green, Dido] Oxford Brookes Univ, Ctr Rehabil, Oxford OX3 0BP, England.
   [Sparrowhawk, Masako; Allgar, Victoria; Wiggs, Luci] Oxford Brookes Univ, Dept Psychol, Oxford OX3 0BP, England.
   [Wright, Barry; Hooke, Naomi; Moore, Danielle] Lime Trees Child & Family Unit, York, N Yorkshire, England.
   [Zaiwalla, Zenobia] John Radcliffe Hosp, Dept Clin Neurophysiol, Oxford OX3 9DU, England.
RP Gringras, P (reprint author), St Thomas Hosp, Evelina Childrens Hosp, Lambeth Palace Rd, London SE1 7EH, England.
EM paul.gringras@gstt.nhs.uk
FU Research Autism; Waterloo Foundation; Baily Thomas Charitable Foundation
FX Supported by Research Autism, the Waterloo Foundation, and the Baily
   Thomas Charitable Foundation.
CR Aman M., 1986, ABERRANT BEHAV CHECK
   Aman M., 1994, ABERRANT BEHAV CHECK
   Ayres A. J., 1972, SENSORY INTEGRATION
   Dunn G, 1999, STAT MED, V18, P2863, DOI 10.1002/(SICI)1097-0258(19991115)18:21<2863::AID-SIM238>3.0.CO;2-I
   Green D., 2009, SENSORY BEHAV QUESTI
   Gringras P, 2012, BRIT MED J, V345, DOI 10.1136/bmj.e6664
   Hill CM, 2007, ARCH DIS CHILD, V92, P637, DOI 10.1136/adc.2006.096156
   JAN JE, 1994, DEV MED CHILD NEUROL, V36, P97
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mayes SD, 2009, RES AUTISM SPECT DIS, V3, P931, DOI 10.1016/j.rasd.2009.04.002
   Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071
   O'Callaghan FJK, 1999, DEV MED CHILD NEUROL, V41, P123, DOI 10.1017/S0012162299000237
   Olson Laurette J., 2004, Physical & Occupational Therapy in Pediatrics, V24, P45, DOI 10.1300/J006v24n03_04
   Phillips L, 2004, DEV MED CHILD NEUROL, V46, P771, DOI 10.1017/S001216220400132X
   QUINE L, 1991, J MENT DEFIC RES, V35, P269
   Quine L., 1992, HELPING PARENTS MANA
   Richdale AL, 1999, DEV MED CHILD NEUROL, V41, P60, DOI 10.1017/S0012162299000122
   Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
   RICHMAN N, 1971, J CHILD PSYCHOL PSYC, V12, P5, DOI 10.1111/j.1469-7610.1971.tb01047.x
   Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sadeh A, 2011, SLEEP MED REV, V15, P259, DOI 10.1016/j.smrv.2010.10.001
   Senn S, 2002, CROSS OVER TRIALS CL
   Smith Roley S, 2001, UNDERSTANDING NATURE
   Weiskop S, 2005, DEV MED CHILD NEUROL, V47, P94, DOI 10.1017/S0012162205000186
   Wright B, 2011, J AUTISM DEV DISORD, V41, P175, DOI 10.1007/s10803-010-1036-5
NR 27
TC 1
Z9 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD AUG
PY 2014
VL 134
IS 2
BP 298
EP 306
DI 10.1542/peds.2013-4285
PG 9
WC Pediatrics
SC Pediatrics
GA AN0HS
UT WOS:000340266000056
PM 25022743
ER

PT J
AU Dykens, EM
   Fisher, MH
   Taylor, JL
   Lambert, W
   Miodrag, N
AF Dykens, Elisabeth M.
   Fisher, Marisa H.
   Taylor, Julie Lounds
   Lambert, Warren
   Miodrag, Nancy
TI Reducing Distress in Mothers of Children With Autism and Other
   Disabilities: A Randomized Trial
SO PEDIATRICS
LA English
DT Article
DE autism spectrum disorders; developmental disabilities; maternal stress
   and mental health; mindfulness based stress reduction; positive
   psychology
ID POSITIVE PSYCHOLOGY INTERVENTIONS; DEVELOPMENTAL-DISABILITIES; PARENTING
   STRESS; DEPRESSIVE SYMPTOMS; BEHAVIOR PROBLEMS; INTELLECTUAL DISABILITY;
   MENTAL-HEALTH; METAANALYSIS; MINDFULNESS; VALIDATION
AB BACKGROUND: Compared with other parents, mothers of children with autism spectrum disorder or other neurodevelopmental disabilities experience more stress, illness, and psychiatric problems. Although the cumulative stress and disease burden of these mothers is exceptionally high, and associated with poorer outcomes in children, policies and practices primarily serve the identified child with disabilities.
   METHODS: A total of 243 mothers of children with disabilities were consented and randomized into either Mindfulness-Based Stress Reduction (mindfulness practice) or Positive Adult Development (positive psychology practice). Well-trained, supervised peer mentors led 6 weeks of group treatments in 1.5-hour weekly sessions, assessing mothers 6 times before, during, and up to 6 months after treatment. Mothers had children with autism (65%) or other disabilities (35%). At baseline, 85% of this community sample had significantly elevated stress, 48% were clinically depressed, and 41% had anxiety disorders.
   RESULTS: Using slopes-as-outcomes, mixed random effects models, both treatments led to significant reductions in stress, depression, and anxiety, and improved sleep and life satisfaction, with large effects in depression and anxiety. Mothers in Mindfulness-Based Stress Reduction versus Positive Adult Development had greater improvements in anxiety, depression, sleep, and well-being. Mothers of children with autism spectrum disorder improved less in anxiety, but did not otherwise differ from their counterparts.
   CONCLUSIONS: Future studies are warranted on how trained mentors and professionals can address the unmet mental health needs of mothers of children with developmental disabilities. Doing so improves maternal wellbeing and furthers their long-term caregiving of children with complex developmental, physical, and behavioral needs.
C1 [Dykens, Elisabeth M.; Fisher, Marisa H.; Taylor, Julie Lounds; Lambert, Warren] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37203 USA.
   [Dykens, Elisabeth M.; Fisher, Marisa H.; Taylor, Julie Lounds; Lambert, Warren] Vanderbilt Univ, Univ Ctr Excellence Dev Disabil, Nashville, TN 37203 USA.
   [Dykens, Elisabeth M.] Vanderbilt Univ, Dept Psychol & Human Dev, Nashville, TN 37203 USA.
   [Dykens, Elisabeth M.; Taylor, Julie Lounds] Vanderbilt Univ, Dept Pediat, Nashville, TN 37203 USA.
   [Dykens, Elisabeth M.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA.
   [Miodrag, Nancy] Calif State Univ Northridge, Dept Child & Adolescent Dev, Northridge, CA 91330 USA.
RP Dykens, EM (reprint author), Vanderbilt Univ, Vanderbilt Kennedy Ctr, 1 Magnolia Circle,Peabody Box 40, Nashville, TN 37203 USA.
EM Elisabeth.dykens@vanderbilt.edu
FU National Institutes of Health's (NIH) National Center for Complementary
   and Alternative Medicine [5RC1AT005612]; NIH's Eunice Kennedy Shriver
   National Institute of Child Health and Human Development [P30HD015052];
   NIH's National Center for Advancing Translational Sciences
   [UL1TR000445]; National Institute of Mental Health [K01MH92598];
   National Institutes of Health (NIH)
FX Supported by the National Institutes of Health's (NIH) National Center
   for Complementary and Alternative Medicine grant 5RC1AT005612 to the
   first author, and used core research services provided by NIH's Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   grant P30HD015052 to the Vanderbilt Kennedy Center, and NIH's National
   Center for Advancing Translational Sciences award UL1TR000445 to
   Vanderbilt University. Dr Taylor's participation was supported by
   K01MH92598, National Institute of Mental Health. Funded by the National
   Institutes of Health (NIH).
CR Abidin R., 1995, PARENT STRESS INDEX
   Anderson LL, 2011, 2010 FINDS NATL SURV
   Baer RA, 2003, CLIN PSYCHOL-SCI PR, V10, P125, DOI 10.1093/clipsy/bpg015
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Beck A. T., 1990, MANUAL BECK ANXIETY
   Beck A.T., 1996, MANUAL BECK DEPRESSI
   Bell ML, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e8668
   Bellg AJ, 2004, HEALTH PSYCHOL, V23, P443, DOI 10.1037/0278-6133.23.5.443
   Bolier L, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-119
   Braddock DL, 2011, STATE STATES DEV DIS
   Brown KW, 2007, PSYCHOL INQ, V18, P211
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Cohn MA, 2010, J POSIT PSYCHOL, V5, P355, DOI 10.1080/17439760.2010.508883
   Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
   DIENER E, 1985, J PERS ASSESS, V49, P71, DOI 10.1207/s15327752jpa4901_13
   Diggle P, 2002, ANAL LONGITUDINAL DA, V2nd
   Duncan LG, 2009, CLIN CHILD FAM PSYCH, V12, P255, DOI 10.1007/s10567-009-0046-3
   Dykens EM, 2000, J CHILD PSYCHOL PSYC, V41, P407, DOI 10.1017/S0021963000005667
   Dykens EM, 2013, J AUTISM DEV DISORD, V43, P2426, DOI 10.1007/s10803-013-1791-1
   Dykens EM, 2006, AM J ORTHOPSYCHIAT, V76, P185, DOI 10.1037/0002-9432.76.2.185
   Epel ES, 2004, P NATL ACAD SCI USA, V101, P17312, DOI 10.1073/pnas.0407162101
   Gallagher S, 2010, J PEDIATR PSYCHOL, V35, P728, DOI 10.1093/jpepsy/jsp093
   Gallagher S, 2009, BRAIN BEHAV IMMUN, V23, P338, DOI 10.1016/j.bbi.2008.05.006
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Griffith GM, 2010, J AUTISM DEV DISORD, V40, P610, DOI 10.1007/s10803-009-0906-1
   Halfon N, 2012, FUTURE CHILD, V22, P13
   Hassall R, 2005, J INTELL DISABIL RES, V49, P405, DOI 10.1111/j.1365-2788.2005.00673.x
   Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
   Heneghan AM, 2000, PEDIATRICS, V106, P1367, DOI 10.1542/peds.106.6.1367
   Heneghan AM, 2004, PEDIATRICS, V113, P460, DOI 10.1542/peds.113.3.460
   Hofmann SG, 2010, J CONSULT CLIN PSYCH, V78, P169, DOI 10.1037/a0018555
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kazdin AE, 2013, CLIN PSYC SCI, V23, P170, DOI DOI 10.1177/2167702612463566
   Ludwig DS, 2008, JAMA-J AM MED ASSOC, V300, P1350, DOI 10.1001/jama.300.11.1350
   Matson JL, 2009, RES DEV DISABIL, V30, P961, DOI 10.1016/j.ridd.2009.01.009
   Miodrag N, 2010, CURR OPIN PSYCHIATR, V23, P407, DOI 10.1097/YCO.0b013e32833a8796
   Neece CL, 2012, AJIDD-AM J INTELLECT, V117, P48, DOI 10.1352/1944-7558-117.1.48
   Olson AL, 2006, PEDIATRICS, V118, P207, DOI 10.1542/peds.2005-2346
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Parish SL, 2008, EXCEPT CHILDREN, V75, P71
   Piven J, 2001, AM J MED GENET, V105, P34, DOI 10.1002/1096-8628(20010108)105:1<34::AID-AJMG1052>3.0.CO;2-D
   Robertson J, 2011, HEALTH SOC CARE COMM, V19, P337, DOI 10.1111/j.1365-2524.2010.00977.x
   RYFF CD, 1995, J PERS SOC PSYCHOL, V69, P719, DOI 10.1037/0022-3514.69.4.719
   Seligman MEP, 2005, AM PSYCHOL, V60, P410, DOI 10.1037/0003-066X.60.5.410
   Seltzer MM, 2011, AJIDD-AM J INTELLECT, V116, P479, DOI 10.1352/1944-7558-116.6.479
   Seltzer MM, 2010, J AUTISM DEV DISORD, V40, P457, DOI 10.1007/s10803-009-0887-0
   Sin NL, 2009, J CLIN PSYCHOL, V65, P467, DOI 10.1002/jclp.20593
   Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
   Singer GHS, 2007, MENT RETARD DEV D R, V13, P357, DOI 10.1002/mrdd.20175
   Singer J. D., 2003, APPL LONGITUDINAL DA
   Tang YY, 2013, SOC COGN AFFECT NEUR, V8, P1, DOI 10.1093/scan/nss104
   Taylor JL, 2012, J AUTISM DEV DISORD, V42, P1411, DOI 10.1007/s10803-011-1375-x
   Wickramaratne P, 2011, AM J PSYCHIAT, V168, P593, DOI 10.1176/appi.ajp.2010.10010032
NR 53
TC 1
Z9 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD AUG
PY 2014
VL 134
IS 2
BP E454
EP E463
DI 10.1542/peds.2013-3164
PG 10
WC Pediatrics
SC Pediatrics
GA AN0HS
UT WOS:000340266000017
PM 25049350
ER

PT J
AU Cheak-Zamora, NC
   Farmer, JE
   Mayfield, WA
   Clark, MJ
   Marvin, AR
   Law, JK
   Law, PA
AF Cheak-Zamora, Nancy C.
   Farmer, Janet E.
   Mayfield, Wayne A.
   Clark, Mary J.
   Marvin, Alison R.
   Law, J. Kiely
   Law, Paul A.
TI Health Care Transition Services for Youth With Autism Spectrum Disorders
SO REHABILITATION PSYCHOLOGY
LA English
DT Article
DE autism spectrum disorder; adolescence; health care services; health care
   transition
ID UNITED-STATES; NATIONAL-SURVEY; MEDICAL HOME; UNMET NEEDS; DSM-IV;
   CHILDREN; ADOLESCENTS; FAMILY; PERSPECTIVES; INDIVIDUALS
AB Objective: Little is known about accessibility to health care transition (HCT) services (HCT) for youth with autism spectrum disorders (ASD). This study examined how often youth with ASD receive HCT services and how access varied by individual, family, and health system characteristics. Method: Questionnaires were completed by 101 parents of youth with ASD (ages 12-17 years) enrolled in a national online autism registry. Descriptive statistics and bivariate analysis were used to examine a composite HCT variable and its components. Results: Fewer than 15% of youth received HCT services. Although 41% received at least 1 HCT discussion, only 3% received all 3. One-quarter had a discussion with their health care provider about transitioning to an adult provider, adult health care needs, or insurance retention, and 31% of providers encouraged youth to take on more responsibilities. Most caregivers reported not needing 1 or more of the discussions. Results varied significantly when the sample was divided by age, with older youth more likely to have received transition services than younger adolescents. Conclusions: These findings indicate a significant disparity in access to HCT services for youth with ASD. Further research is needed to understand this disparity and develop interventions to improve HCT both for youth with ASD and those with other disabling health conditions. Additionally, many caregivers do not recognize the importance of HCT services. Education and training for caregivers, youth, and providers is essential to ensure all parties are working together to address transition issues early and often.
C1 [Cheak-Zamora, Nancy C.] Univ Missouri, Dept Hlth Sci, Columbia, MO 65211 USA.
   [Farmer, Janet E.] Univ Missouri, Dept Hlth Psychol, Columbia, MO 65211 USA.
   [Mayfield, Wayne A.] Univ Missouri, Off Social & Econ Data Anal, Columbia, MO 65211 USA.
   [Clark, Mary J.] Univ Missouri, Atkins Wellness Program, Columbia, MO 65211 USA.
   [Marvin, Alison R.; Law, J. Kiely; Law, Paul A.] Kennedy Krieger Inst, Dept Med Informat, Baltimore, MD USA.
   [Law, J. Kiely; Law, Paul A.] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21218 USA.
RP Cheak-Zamora, NC (reprint author), Univ Missouri, 510 Clark Hall, Columbia, MO 65211 USA.
EM cheakzamoran@health.missouri.edu
CR American Academy of Pediatrics American Academy of Family Physicians American College of Physicians, 2011, PEDIATRICS, V128, P182, DOI DOI 10.1542/PEDS.2011-0969
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT, V5th
   Autism Speaks, 2011, AUT SPEAKS RES GUID
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   BLUM RW, 1993, J ADOLESCENT HEALTH, V14, P570, DOI 10.1016/1054-139X(93)90143-D
   Brachlow AE, 2007, ARCH PEDIAT ADOL MED, V161, P399, DOI 10.1001/archpedi.161.4.399
   Carlson MJ, 2002, J BEHAV HEALTH SER R, V29, P481
   Cheak-Zamora NC, 2013, PEDIATRICS, V131, P447, DOI 10.1542/peds.2012-1572
   Child and Adolescent Health Measurement Initiative, 2013, NAT PROF CHILDR SPEC
   Child and Adolescent Health Measurement Initiative, 2012, NAT PROF CHILDR SPEC
   Child and Adolescent Health Measurement Initiative, 2009, RES MAN CHILD HLTH P, P1
   Coury D, 2009, CURR OPIN PEDIATR, V21, P828, DOI 10.1097/MOP.0b013e328331eaaa
   Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7
   Farmer JE, 2014, MATERN CHILD HLTH J, V18, P672, DOI 10.1007/s10995-013-1292-z
   Ganz ML, 2006, PEDIATRICS, V117, P2138, DOI 10.1542/peds.2005-1531
   Hess JS, 2011, J PEDIATR PSYCHOL, V36, P172, DOI 10.1093/jpepsy/jsq091
   Holtz K., 2006, LIFE JOURNEY AUTISM
   Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
   Interactive Autism Network, 2011, INT AUT NETW LINK AU
   Kane D. J., 2009, PEDIATRICS, V124, pS375, DOI [10.1542/peds.2009-1255H, DOI 10.1542/PEDS.2009-1255H]
   Kingsnorth S, 2011, CHILD CARE HLTH DEV, V37, P833, DOI 10.1111/j.1365-2214.2011.01294.x
   Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
   Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
   Lotstein DS, 2009, PEDIATRICS, V123, pE145, DOI 10.1542/peds.2008-1298
   Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P298, DOI 10.1016/j.rasd.2012.08.011
   Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
   McManus MA, 2013, PEDIATRICS, V131, P1090, DOI 10.1542/peds.2012-3050
   McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
   Park MJ, 2011, ACAD PEDIATR, V11, P115, DOI 10.1016/j.acap.2010.11.010
   Peter NG, 2009, PEDIATRICS, V123, P417, DOI 10.1542/peds.2008-0740
   Reiss J, 2002, PEDIATRICS, V110, P1307
   Reiss JG, 2005, PEDIATRICS, V115, P112, DOI 10.1542/peds.2004-1321
   Richardson LE, 2013, J CONSUM AFF, V47, P191, DOI 10.1111/joca.12005
   Roohan PJ, 2003, HEALTH SERV RES, V38, P1121, DOI 10.1111/1475-6773.00166
   Scal P, 2009, ARTHRIT RHEUM-ARTHR, V61, P52, DOI 10.1002/art.24088
   Test D., 2009, CAREER DEV EXCEPTION, V32, P160, DOI DOI 10.1177/0885728809346960
   Tregnago MK, 2012, RES AUTISM SPECT DIS, V6, P1023, DOI 10.1016/j.rasd.2012.01.005
NR 37
TC 0
Z9 0
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 0090-5550
EI 1939-1544
J9 REHABIL PSYCHOL
JI Rehabil. Psychol.
PD AUG
PY 2014
VL 59
IS 3
BP 340
EP 348
DI 10.1037/a0036725
PG 9
WC Psychology, Clinical; Rehabilitation
SC Psychology; Rehabilitation
GA AN2RH
UT WOS:000340432500011
PM 25019309
ER

PT J
AU Telias, M
   Ben-Yosef, D
AF Telias, Michael
   Ben-Yosef, Dalit
TI Modeling Neurodevelopmental Disorders Using Human Pluripotent Stem Cells
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Article
DE Human pluripotent stem cells; Neurodevelopmental disorders; Disease
   models; Neural differentiation; Electrophysiology
ID FRAGILE-X-SYNDROME; AUTISM SPECTRUM DISORDERS; PRADER-WILLI-SYNDROME;
   LESCH-NYHAN-SYNDROME; PREIMPLANTATION GENETIC DIAGNOSIS; NEURAL
   PROGENITOR CELLS; IPSC-DERIVED NEURONS; DOWN-SYNDROME; RETT-SYNDROME;
   IN-VITRO
AB Neurodevelopmental disorders (NDs) are impairments that affect the development and growth of the brain and the central nervous system during embryonic and early postnatal life. Genetically manipulated animals have contributed greatly to the advancement of ND research, but many of them differ considerably from the human phenotype. Cellular in vitro models are also valuable, but the availability of human neuronal cells is limited and their lifespan in culture is short. Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, comprise a powerful tool for studying developmentally regulated diseases, including NDs. We reviewed all recent studies in which hPSCs were used as in vitro models for diseases and syndromes characterized by impairment of neurogenesis or synaptogenesis leading to intellectual disability and delayed neurodevelopment. We analyzed their methodology and results, focusing on the data obtained following in vitro neural differentiation and gene expression and profiling of the derived neurons. Electrophysiological recording of action potentials, synaptic currents and response to neurotransmitters is pivotal for validation of the neuronal fate as well as for assessing phenotypic dysfunctions linked to the disease in question. We therefore focused on the studies which included electrophysiological recordings on the in vitro-derived neurons. Finally, we addressed specific issues that are critical for the advancement of this area of research, specifically in providing a reliable human pre-clinical research model and drug screening platform.
C1 [Telias, Michael; Ben-Yosef, Dalit] Tel Aviv Univ, Sackler Fac Med,Wolfe PGD Stem Cell Lab, Dept Cell & Dev Biol, Racine IVF Unit,Lis Matern Hosp, IL-69978 Tel Aviv, Israel.
RP Ben-Yosef, D (reprint author), Tel Aviv Univ, Sackler Fac Med,Wolfe PGD Stem Cell Lab, Dept Cell & Dev Biol, Racine IVF Unit,Lis Matern Hosp, IL-69978 Tel Aviv, Israel.
EM dalitb@tlvmc.gov.il
FU NNE-Teva scholarship; Tel-Aviv Medical Center
FX We thank Prof. Menahem Segal from the Department of Neurobiology at
   Weizmann Institute of Science, and Dr. Mira Malcov and Dr. Yael Kalma
   from the Wolfe PGD-Stem Cell Lab at Tel-Aviv Sourasky Medical Center,
   for critical reading of the manuscript. Esther Eshkol is thanked for
   editorial assistance. This study was supported by NNE-Teva scholarship
   (M. Telias) and Tel-Aviv Medical Center (D. Ben-Yosef).
CR ABITBOL M, 1993, NAT GENET, V4, P147, DOI 10.1038/ng0693-147
   Alisch RS, 2013, BMC MED GENET, V14, DOI 10.1186/1471-2350-14-18
   Ameen C, 2008, CRIT REV ONCOL HEMAT, V65, P54, DOI 10.1016/j.critrevonc.2007.06.012
   Amenduni M, 2011, EUR J HUM GENET, V19, P1246, DOI 10.1038/ejhg.2011.131
   Ananiev G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025255
   [Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
   Aran B, 2012, J ASSIST REPROD GEN, V29, P1013, DOI 10.1007/s10815-012-9820-0
   Ascano M, 2012, NATURE, V492, P382, DOI 10.1038/nature11737
   Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108
   Badger JL, 2014, NEUROPHARMACOLOGY, V76, P88, DOI 10.1016/j.neuropharm.2013.08.035
   Barkovich AJ, 2012, BRAIN, V135, P1348, DOI 10.1093/brain/aws019
   Bar-Nur O, 2012, J MOL CELL BIOL, V4, P180, DOI 10.1093/jmcb/mjs007
   Bellenchi GC, 2013, J NEUROCHEM, V124, P159, DOI 10.1111/jnc.12084
   Ben-Nun IF, 2006, MOL CELL ENDOCRINOL, V252, P154, DOI 10.1016/j.mce.2006.03.034
   Ben-Yehudah Ahmi, 2012, Methods Mol Biol, V873, P179, DOI 10.1007/978-1-61779-794-1_11
   Ben-Yosef D, 2012, STEM CELLS DEV, V21, P363, DOI 10.1089/scd.2011.0102
   Ben-Yosef D, 2008, MOL CELL ENDOCRINOL, V282, P153, DOI 10.1016/j.mce.2007.11.010
   Berlucchi G, 2009, EXP BRAIN RES, V192, P307, DOI 10.1007/s00221-008-1611-6
   Biancotti Juan-Carlos, 2012, Methods Mol Biol, V873, P163, DOI 10.1007/978-1-61779-794-1_10
   Biancotti JC, 2010, STEM CELLS, V28, P1530, DOI 10.1002/stem.483
   Boissart C, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.71
   Bourgeois J P, 1997, Acta Paediatr Suppl, V422, P27
   Braam SR, 2010, METHODS MOL BIOL, V584, P413, DOI 10.1007/978-1-60761-369-5_22
   Briggs JA, 2013, STEM CELLS, V31, P467, DOI 10.1002/stem.1297
   Budimirovic DB, 2011, DEV NEUROSCI-BASEL, V33, P379, DOI 10.1159/000330213
   Byrne J. A., 2008, HUM MOL GENET, V17, P37
   Canzonetta C, 2008, AM J HUM GENET, V83, P388, DOI 10.1016/j.ajhg.2008.08.012
   Cardenas AM, 2012, ARCH MED RES, V43, P645, DOI 10.1016/j.arcmed.2012.10.012
   Cassidy SB, 2012, GENET MED, V14, P10, DOI 10.1038/gim.0b013e31822bead0
   Castren M, 2005, P NATL ACAD SCI USA, V102, P17834, DOI 10.1073/pnas.0508995102
   Chaboub LS, 2012, DEV NEUROSCI-BASEL, V34, P379, DOI 10.1159/000343723
   Chailangkarn T, 2012, CURR OPIN NEUROBIOL, V22, P785, DOI 10.1016/j.conb.2012.04.004
   Chamberlain SJ, 2010, NEUROBIOL DIS, V39, P13, DOI 10.1016/j.nbd.2010.03.011
   Chamberlain SJ, 2010, P NATL ACAD SCI USA, V107, P17668, DOI 10.1073/pnas.1004487107
   Chambers SM, 2009, NAT BIOTECHNOL, V27, P275, DOI 10.1038/nbt.1529
   Chambers SM, 2011, METHODS MOL BIOL, V793, P87, DOI 10.1007/978-1-61779-328-8_6
   Chanda S, 2013, P NATL ACAD SCI USA, V110, P16622, DOI 10.1073/pnas.1316240110
   Chen B.C., 2013, TREATMENT LESCH NYHA
   Cheung AYL, 2011, HUM MOL GENET, V20, P2103, DOI 10.1093/hmg/ddr093
   Chou ST, 2012, P NATL ACAD SCI USA, V109, P17573, DOI 10.1073/pnas.1211175109
   Clegg J, 2013, CURR OPIN PSYCHIATR, V26, P289, DOI 10.1097/YCO.0b013e32835f6771
   Coe BP, 2012, CURR OPIN NEUROBIOL, V22, P829, DOI 10.1016/j.conb.2012.04.007
   Cohen-Kutner M, 2012, SCI REP-UK, V2, DOI 10.1038/srep00366
   Conti L, 2010, NAT REV NEUROSCI, V11, P176, DOI 10.1038/nrn2761
   Creau N., 2012, NEURAL PLAST, V2012
   Crocco MC, 2013, J ASSIST REPROD GEN, V30, P315, DOI 10.1007/s10815-012-9914-8
   Cundiff PE, 2011, CURR OPIN GENET DEV, V21, P354, DOI 10.1016/j.gde.2011.01.008
   Daadi Marcel M., 2008, V438, P205, DOI 10.1007/978-1-59745-133-8_17
   Darbinyan A, 2013, METHODS MOL BIOL, V1078, P45, DOI 10.1007/978-1-62703-640-5_5
   Darr H, 2006, REGEN MED, V1, P317, DOI 10.2217/17460751.1.3.317
   Deb KD, 2008, REJUV RES, V11, P19, DOI 10.1089/rej.2007.0558
   Deleidi M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019926
   DeRosa BA, 2012, NEUROSCI LETT, V516, P9, DOI 10.1016/j.neulet.2012.02.086
   Di Giorgio FP, 2007, NAT NEUROSCI, V10, P608, DOI 10.1038/nn1885
   Di Stefano B, 2011, STEM CELLS, V29, P1684, DOI 10.1002/stem.726
   Doherty AMO, 2003, MAMM GENOME, V14, P583, DOI 10.1007/s00335-003-4002-0
   Dvash T, 2004, BEST PRACT RES CL OB, V18, P929, DOI 10.1016/j.bpobgyn.2004.06.005
   Dvash T, 2006, PEDIATR RES, V60, P111, DOI 10.1203/01.pdr.0000228349.24676.17
   Edwards R G, 2002, Reprod Biomed Online, V4, P263
   Edwards RG, 2005, REPROD BIOMED ONLINE, V10, P1
   Eiges R, 2007, CELL STEM CELL, V1, P568, DOI 10.1016/j.stem.2007.09.001
   Elkabetz Y, 2008, COLD SH Q B, V73, P377, DOI 10.1101/sqb.2008.73.052
   Epsztejn-Litman S, 2010, METHODS MOL BIOL, V584, P387, DOI 10.1007/978-1-60761-369-5_21
   Fan Y, 2010, J REPROD DEVELOP, V56, P533, DOI 10.1262/jrd.09-225M
   Farra N, 2012, MOL PSYCHIATR, V17, P1261, DOI 10.1038/mp.2011.180
   Fernandes AM, 2010, CELL TRANSPLANT, V19, P509, DOI 10.3727/096368909X485067
   Fernandez E, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00191
   Friedman S.H., 2013, DIS MODEL MECH
   Frumkin T, 2010, IN VITRO CELL DEV-AN, V46, P327, DOI 10.1007/s11626-010-9275-5
   Gadad BS, 2013, AUTISM RES TREAT, V2013, DOI DOI 10.1155/2013/731935
   Gargus JJ, 2006, BIOL PSYCHIAT, V60, P177, DOI 10.1016/j.biopsych.2005.12.008
   Gepstein L, 2002, CIRC RES, V91, P866, DOI 10.1161/01.RES.0000041435.95082.84
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Goldstein S., 1999, HDB NEURODEVELOPMENT, p[602, xvi]
   Grabowski GA, 2012, HEMATOL-AM SOC HEMAT, P13, DOI 10.1182/asheducation-2012.1.13
   Grade S., 2013, INT J DEV NEUROSCI
   Guemni R., 2012, EPILEPSIA, V53, P2067
   Hagerman P, 2013, ACTA NEUROPATHOL, V126, P1, DOI 10.1007/s00401-013-1138-1
   Hagerman R, 2013, LANCET NEUROL, V12, P786, DOI 10.1016/S1474-4422(13)70125-X
   Hagerman RJ, 2006, J DEV BEHAV PEDIATR, V27, P63, DOI 10.1097/00004703-200602000-00012
   HERGERSBERG M, 1995, HUM MOL GENET, V4, P359, DOI 10.1093/hmg/4.3.359
   Hernandez D, 1999, HUM MOL GENET, V8, P923, DOI 10.1093/hmg/8.5.923
   Hotta A, 2009, NAT METHODS, V6, P370, DOI [10.1038/nmeth.1325, 10.1038/NMETH.1325]
   Hrvoj-Mihic B, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00707
   Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
   Ilic D, 2010, STEM CELLS DEV, V19, P39, DOI 10.1089/scd.2009.0136
   Izrael M, 2007, MOL CELL NEUROSCI, V34, P310, DOI 10.1016/j.mcn.2006.11.008
   Jaroudi Souraya, 2013, Methods Mol Biol, V957, P267, DOI 10.1007/978-1-62703-191-2_19
   Jayaseelan S, 2012, NATURE, V492, P359, DOI 10.1038/nature11764
   Jeste S.S., 2014, NAT REV NEUROL
   Jiang J, 2013, NATURE, V500, P296, DOI 10.1038/nature12394
   Jinnah HA, 2006, BRAIN, V129, P1201, DOI 10.1093/brain/awl056
   Johnson MA, 2007, J NEUROSCI, V27, P3069, DOI 10.1523/JNEUROSCI.4562-06.2007
   Kallay K, 2012, METAB BRAIN DIS, V27, P193, DOI 10.1007/s11011-012-9279-9
   Kallur T, 2006, J NEUROSCI RES, V84, P1630, DOI 10.1002/jnr.21066
   Kallur T, 2008, MOL CELL NEUROSCI, V38, P616, DOI 10.1016/j.mcn.2008.05.010
   Kernohan KD, 2010, EPIGENOMICS-UK, V2, P743, DOI [10.2217/epi.10.61, 10.2217/EPL10.61]
   Khan IF, 2010, MOL THER, V18, P1192, DOI 10.1038/mt.2010.55
   Kim JE, 2011, P NATL ACAD SCI USA, V108, P3005, DOI 10.1073/pnas.1007753108
   Kim KY, 2011, P NATL ACAD SCI USA, V108, P14169, DOI 10.1073/pnas.1018979108
   Korkmaz B, 2011, PEDIATR RES, V69, p101R, DOI 10.1203/PDR.0b013e318212c177
   Krey JF, 2013, NAT NEUROSCI, V16, P201, DOI 10.1038/nn.3307
   Lancaster MA, 2013, NATURE, V501, P373, DOI 10.1038/nature12517
   Larimore J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065069
   LaVaute TM, 2009, STEM CELLS, V27, P1741, DOI 10.1002/stem.99
   Levenga J, 2011, NEUROBIOL LEARN MEM, V95, P467, DOI 10.1016/j.nlm.2011.02.009
   Li LB, 2012, CELL STEM CELL, V11, P615, DOI 10.1016/j.stem.2012.08.004
   Li M, 2013, J BIOL CHEM
   Li XJ, 2008, STEM CELLS, V26, P886, DOI 10.1634/stemcells.2007-0620
   Lin MY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023356
   Lin MY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044017
   Little J, 2000, PROSTAG LEUKOTR ESS, V63, P11, DOI 10.1054/plef.2000.0185
   Liu J, 2012, HUM MOL GENET, V21, P3795, DOI 10.1093/hmg/dds207
   Liu Y, 2011, CELL REPROGRAM, V13, P233, DOI 10.1089/cell.2010.0092
   Loesch D, 2012, ADV EXP MED BIOL, V769, P78
   Lott IT, 2012, PROG BRAIN RES, V197, P101, DOI 10.1016/B978-0-444-54299-1.00006-6
   Lu HE, 2013, EXP CELL RES, V319, P498, DOI 10.1016/j.yexcr.2012.09.017
   Lu J., 2011, J VIS EXP
   Mackay-Sim A, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00029
   MacLean GA, 2012, P NATL ACAD SCI USA, V109, P17567, DOI 10.1073/pnas.1215468109
   Manning MA, 2007, NEUROSCI BIOBEHAV R, V31, P230, DOI 10.1016/j.neubiorev.2006.06.016
   Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
   Mastrangelo L, 2012, P NATL ACAD SCI USA, V109, P3377, DOI 10.1073/pnas.1118067109
   Mayer EJ, 2005, BRIT J OPHTHALMOL, V89, P102, DOI 10.1136/bjo.2004.057687
   Mekhoubad S, 2012, CELL STEM CELL, V10, P595, DOI 10.1016/j.stem.2012.02.014
   Menendez P, 2005, CURR GENE THER, V5, P375, DOI 10.2174/1566523054546198
   Meng GL, 2010, BIOCHEM CELL BIOL, V88, P479, DOI [10.1139/o09-188, 10.1139/O09-188]
   Mou XN, 2012, STEM CELL RES THER, V3, DOI 10.1186/scrt105
   Muguruma K, 2012, DEV GROWTH DIFFER, V54, P349, DOI 10.1111/j.1440-169X.2012.01329.x
   Muotri AR, 2010, NATURE, V468, P443, DOI 10.1038/nature09544
   Na ES, 2013, NEUROPSYCHOPHARMACOL, V38, P212, DOI 10.1038/npp.2012.116
   Nakano T, 2012, CELL STEM CELL, V10, P771, DOI 10.1016/j.stem.2012.05.009
   Neul Jeffrey Lorenz, 2012, Dialogues Clin Neurosci, V14, P253
   Ng MC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051456
   Nichols J, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a008128
   Nowakowski RS, 1999, DEV PSYCHOPATHOL, V11, P395, DOI 10.1017/S0954579499002126
   Nyhan WL, 1997, J INHERIT METAB DIS, V20, P171, DOI 10.1023/A:1005348504512
   Nyhan W.L., 1993, GENEREVIEWS
   OPITZ JM, 1990, AM J MED GENET, P38
   Osterhues A, 2013, CRIT REV FOOD SCI, V53, P1180, DOI 10.1080/10408398.2011.575966
   Panicker LM, 2012, P NATL ACAD SCI USA, V109, P18054, DOI 10.1073/pnas.1207889109
   Park IH, 2008, CELL, V134, P877, DOI 10.1016/j.cell.2008.07.041
   Parker SE, 2010, BIRTH DEFECTS RES A, V88, P1008, DOI 10.1002/bdra.20735
   Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
   Patterson T, 2013, J INTELL DISABIL RES, V57, P306, DOI [10.1111/jir.12037, 10.1111/j.1365-2788.2012.01536.x]
   Peitz M, 2013, CURR MOL MED, V13, P832
   Penagarikano O, 2007, ANNU REV GENOM HUM G, V8, P109, DOI 10.1146/annurev.genom.8.080706.092249
   Percy AK, 2011, ARCH NEUROL-CHICAGO, V68, P985, DOI 10.1001/archneurol.2011.149
   Petersen M C, 1998, Semin Pediatr Neurol, V5, P2, DOI 10.1016/S1071-9091(98)80012-0
   Pichichero ME, 2009, ADV EXP MED BIOL, V634, P205, DOI 10.1007/978-0-387-79838-7_17
   Piggot J, 2009, NEUROSCIENCE, V164, P247, DOI 10.1016/j.neuroscience.2009.05.054
   Poduri A, 2013, SCIENCE, V341, P43, DOI 10.1126/science.1237758
   Pomp O, 2011, CELL STEM CELL, V9, P156, DOI 10.1016/j.stem.2011.06.004
   Rapin I, 2008, CURR OPIN NEUROL, V21, P143, DOI 10.1097/WCO.0b013e3282f49579
   Ricciardi S, 2012, NAT CELL BIOL, V14, P911, DOI 10.1038/ncb2566
   Rinehart NJ, 2011, CURR TOP BEHAV NEURO, V8, P209, DOI 10.1007/7854_2010_96
   Rosenbloom Barry E., 2013, Critical Reviews in Oncogenesis, V18, P163
   Ryan SG, 1999, J CHILD NEUROL, V14, P187, DOI 10.1177/088307389901400310
   Saito Y, 2000, BRAIN DEV-JPN, V22, pS122
   Sankar Chitra, 2005, Indian Journal of Pediatrics, V72, P865, DOI 10.1007/BF02731117
   Santangelo SL, 2005, AM J PHARMACOGENOMIC, V5, P71, DOI 10.2165/00129785-200505020-00001
   Schendel D, 2010, ADV EXP MED BIOL, V686, P433, DOI 10.1007/978-90-481-9485-8_24
   Schendel D E, 2001, J Am Med Womens Assoc, V56, P105
   Schuurmans C, 2013, CLIN GENET, V83, P108, DOI 10.1111/cge.12049
   Sequerra EB, 2013, DEVELOPMENT, V140, P3303, DOI 10.1242/dev.093096
   Sheridan SD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026203
   Shi Y., 2012, SCI TRANSL MED, V4, P124, DOI DOI 10.1126/SCITRANSLMED.3003771
   Shinoda Y, 2013, EXP ANIM TOKYO, V62, P71
   Sidorov MS, 2013, MOL BRAIN, V6, DOI 10.1186/1756-6606-6-15
   Sidransky E, 2012, DISCOV MED, V77, P273
   Skuse David H., 1997, Current Opinion in Pediatrics, V9, P354
   Soldner F, 2011, CELL, V146, P318, DOI 10.1016/j.cell.2011.06.019
   Stamou M, 2013, NEUROTOXICOL TERATOL, V36, P3, DOI 10.1016/j.ntt.2012.12.001
   Stiles J, 2010, NEUROPSYCHOL REV, V20, P327, DOI 10.1007/s11065-010-9148-4
   Strelchenko N, 2006, METHOD ENZYMOL, V418, P93, DOI 10.1016/S0076-6879(06)18006-4
   Studer L, 2010, NATURE, V468, P383, DOI 10.1038/468383a
   Sturgeon X, 2012, PROG BRAIN RES, V197, P73, DOI 10.1016/B978-0-444-54299-1.00005-4
   Taei A, 2010, IN VITRO CELL DEV-AN, V46, P395, DOI 10.1007/s11626-010-9293-3
   Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
   Takahashi K, 2006, CELL, V126, P663, DOI 10.1016/j.cell.2006.07.024
   Telias M, 2013, DEV BIOL, V374, P32, DOI 10.1016/j.ydbio.2012.11.031
   Thibert RL, 2013, PEDIATR NEUROL, V48, P271, DOI 10.1016/j.pediatrneurol.2012.09.015
   Thomson JA, 1998, SCIENCE, V282, P1145, DOI 10.1126/science.282.5391.1145
   Tiscornia G, 2013, HUM MOL GENET, V22, P633, DOI 10.1093/hmg/dds471
   Toimesen J., 2011, PLOS ONE, V6
   Tornero D., 2013, BRAIN
   Trappe R, 2001, AM J HUM GENET, V68, P1093, DOI 10.1086/320109
   Tropel P, 2010, IN VITRO CELL DEV-AN, V46, P376, DOI 10.1007/s11626-010-9300-8
   Unger C, 2008, HUM MOL GENET, V17, pR48, DOI 10.1093/hmg/ddn079
   Urbach A, 2010, CELL STEM CELL, V6, P407, DOI 10.1016/j.stem.2010.04.005
   Urbach A, 2004, STEM CELLS, V22, P635, DOI 10.1634/stemcells.22-4-635
   Van Wijngaarden-Cremers P.J., 2013, J AUTISM DEV DISORD
   van Eyk CL, 2012, ADV EXP MED BIOL, V769, P55
   van Loo KMJ, 2007, CURR GENOMICS, V8, P429, DOI 10.2174/138920207783591717
   Vazin T, 2010, RESTOR NEUROL NEUROS, V28, P589, DOI 10.3233/RNN-2010-0543
   Verlinsky Y, 2005, REPROD BIOMED ONLINE, V10, P105
   Verwer RWH, 2002, FASEB J, V16, P54, DOI 10.1096/fj.01-0504com
   Visser JE, 2000, BRAIN RES REV, V32, P449, DOI 10.1016/S0165-0173(99)00094-6
   Visser JE, 2011, MOVEMENT DISORD, V26, P746, DOI 10.1002/mds.23478
   Vitner E. B., 2013, HDB EXP PHARM, V216, P405, DOI DOI 10.1007/978-3-7091-1511-4_20
   Volpe P, 2009, PRENATAL DIAG, V29, P340, DOI 10.1002/pd.2208
   Walsh RM, 2010, CELL, V143, P499, DOI 10.1016/j.cell.2010.10.037
   Wang HS, 2012, NEURAL PLAST, DOI 10.1155/2012/346053
   Webster HD, 2009, ADV ANAT EMBRYOL CEL, V202, P1
   Weick JP, 2013, P NATL ACAD SCI USA, V110, P9962, DOI 10.1073/pnas.1216575110
   Weijerman ME, 2010, EUR J PEDIATR, V169, P1445, DOI 10.1007/s00431-010-1253-0
   Weksler ME, 2013, AUTOIMMUN REV, V12, P670, DOI 10.1016/j.autrev.2012.10.013
   Weng SM, 2011, PEDIATR NEONATOL, V52, P309, DOI 10.1016/j.pedneo.2011.08.002
   Whittington J, 2010, AM J MED GENET C, V154C, P438, DOI 10.1002/ajmg.c.30283
   Willemsen R, 2002, HUM GENET, V110, P601, DOI 10.1007/s00439-002-0723-5
   Williamson SL, 2006, EUR J HUM GENET, V14, P896, DOI 10.1038/sj.ejhg.5201580
   Yang JY, 2010, J BIOL CHEM, V285, P40303, DOI 10.1074/jbc.M110.183392
   Yazawa M, 2013, J CARDIOVASC TRANSL, V6, P1, DOI 10.1007/s12265-012-9444-x
   Zeng LY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059685
   Zhang YS, 2013, NEURON, V78, P785, DOI 10.1016/j.neuron.2013.05.029
   Zwaigenbaum L, 2013, BEHAV BRAIN RES, V251, P133, DOI 10.1016/j.bbr.2013.04.004
NR 216
TC 2
Z9 2
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1550-8943
EI 1558-6804
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD AUG
PY 2014
VL 10
IS 4
BP 494
EP 511
DI 10.1007/s12015-014-9507-2
PG 18
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
SC Cell Biology; Research & Experimental Medicine
GA AN3SZ
UT WOS:000340510300005
PM 24728983
ER

PT J
AU Balestrieri, E
   Pitzianti, M
   Matteucci, C
   D'Agati, E
   Sorrentino, R
   Baratta, A
   Caterina, R
   Zenobi, R
   Curatolo, P
   Garaci, E
   Sinibaldi-Vallebona, P
   Pasini, A
AF Balestrieri, Emanuela
   Pitzianti, Mariabernarda
   Matteucci, Claudia
   D'Agati, Elisa
   Sorrentino, Roberta
   Baratta, Antonia
   Caterina, Rosa
   Zenobi, Rossella
   Curatolo, Paolo
   Garaci, Enrico
   Sinibaldi-Vallebona, Paola
   Pasini, Augusto
TI Human endogenous retroviruses and ADHD
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Human endogenous retrovirus; HERV-H; ADHD; neurodevelopmental diseases;
   peripheral blood mononuclear cells
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RISK-FACTORS; AUTISM;
   SCHIZOPHRENIA; PREVALENCE; CHILDREN; GENE; DISCORDANCE; COMORBIDITY;
   SYMPTOMS
AB Objectives. Several lines of evidences suggest that human endogenous retroviruses (HERVs) are implicated in the development of many complex diseases with a multifactorial aetiology and a strong heritability, such as neurological and psychiatric diseases. Attention deficit hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that results from a complex interaction of environmental, biological and genetic factors. Our aim was to analyse the expression levels of three HERV families (HERV-H, K and W) in patients with ADHD. Methods. The expression of retroviral mRNAs from the three HERV families was evaluated in peripheral blood mononuclear cells (PBMCs) from 30 patients with ADHD and 30 healthy controls by quantitative RT-PCR. Results. The expression levels of HERV-H are significantly higher in patients with ADHD compared to healthy controls, while there are no differences in the expression levels of HERV-K and W. Conclusions. Since the ADHD aetiology is due to a complex interaction of environmental, biological and genetic factors, HERVs may represent one link among these factors and clinical phenotype of ADHD. A future confirmation of HERV-H overexpression in a larger number of ADHD patients will make possible to identify it as a new parameter for this clinical condition, also contributing to deepen the study on the role of HERVs in the neurodevelopment diseases.
C1 [Balestrieri, Emanuela; Matteucci, Claudia; Sorrentino, Roberta; Zenobi, Rossella; Garaci, Enrico; Sinibaldi-Vallebona, Paola] Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy.
   [Pitzianti, Mariabernarda; D'Agati, Elisa; Baratta, Antonia; Caterina, Rosa; Curatolo, Paolo; Pasini, Augusto] Univ Roma Tor Vergata, Unit Child Neurol & Psychiat, Dept Neurosci, I-00133 Rome, Italy.
RP Pasini, A (reprint author), Univ Roma Tor Vergata, Unit Child Neurol & Psychiat, Dept Neurosci, Viale Oxford 81, I-00133 Rome, Italy.
EM pasini@uniroma2.it
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Balestrieri E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048831
   Bannert N, 2006, ANNU REV GENOM HUM G, V7, P149, DOI 10.1146/annurev.genom.7.080505.115700
   Benros ME, 2012, ANN NY ACAD SCI, V1262, P56, DOI 10.1111/j.1749-6632.2012.06638.x
   Chandan JV, 2012, CURR TOP BEHAV NEURO, V9, P49
   Christensen T, 2010, J NEUROIMMUNE PHARM, V5, P326, DOI 10.1007/s11481-010-9214-y
   Conners CK, 2007, CONNERS PARENTS RATI
   Conners CK, 2007, CONNERS TEACHERS RAT
   CROW TJ, 1984, BRIT J PSYCHIAT, V145, P243, DOI 10.1192/bjp.145.3.243
   Curatolo P, 2009, EUR J PAEDIATR NEURO, V13, P299, DOI 10.1016/j.ejpn.2008.06.003
   DasBanerjee T, 2008, AM J MED GENET B, V147B, P1554, DOI 10.1002/ajmg.b.30877
   de Parseval N, 2005, CYTOGENET GENOME RES, V110, P318, DOI 10.1159/000084964
   Diem O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030054
   Feschotte C, 2012, NAT REV GENET, V13, P283, DOI 10.1038/nrg3199
   Fraga MF, 2005, P NATL ACAD SCI USA, V102, P10604, DOI 10.1073/pnas.0500398102
   Gilberg C., 1995, CLIN CHILD NEUROPSYC
   Gizer IR, 2009, HUM GENET, V126, P51, DOI 10.1007/s00439-009-0694-x
   Gogvadze E, 2009, CELL MOL LIFE SCI, V66, P3727, DOI 10.1007/s00018-009-0107-2
   Holtmann M, 2007, PSYCHOPATHOLOGY, V40, P172, DOI 10.1159/000100007
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
   LaSalle JM, 2013, J HUM GENET, V58, P396, DOI 10.1038/jhg.2013.49
   Leboyer M, 2013, WORLD J BIOL PSYCHIA, V14, P80, DOI 10.3109/15622975.2010.601760
   Mill J, 2006, AM J MED GENET B, V141B, P421, DOI 10.1002/ajmg.b.30316
   Mill J, 2008, J CHILD PSYCHOL PSYC, V49, P1020, DOI 10.1111/j.1469-7610.2008.01909.x
   Mulligan A, 2009, J AUTISM DEV DISORD, V39, P197, DOI 10.1007/s10803-008-0621-3
   Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
   Ollikainen M, 2011, EPIGENOMICS-UK, V3, P295, DOI [10.2217/epi.11.18, 10.2217/EPI.11.18]
   Perron H, 2012, TRANSL PSYCHIAT, V4, pe201
   Pluess M, 2009, BIOL PSYCHIAT, V66, P5
   Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
   Rhee SH, 2008, J ABNORM CHILD PSYCH, V36, P29, DOI 10.1007/s10802-007-9157-9
   Rowe HM, 2011, VIROLOGY, V411, P273, DOI 10.1016/j.virol.2010.12.007
   Sharp SI, 2009, NEUROPHARMACOLOGY, V57, P590, DOI 10.1016/j.neuropharm.2009.08.011
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
   Sonuga-Barke EJS, 2010, J CHILD PSYCHOL PSYC, V51, P368, DOI 10.1111/j.1469-7610.2009.02195.x
   Steinhausen HC, 2009, ACTA PSYCHIAT SCAND, V120, P392, DOI 10.1111/j.1600-0447.2009.01446.x
   Wang CSM, 2009, J NEUROL NEUROSUR PS, V80, P562, DOI 10.1136/jnnp.2008.151654
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Willcutt E, 2012, NEUROTHERAPEUTICS, V9, P490, DOI 10.1007/s13311-012-0135-8
   Yolken RH, 2000, BRAIN RES REV, V31, P193, DOI 10.1016/S0165-0173(99)00037-5
NR 42
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD AUG
PY 2014
VL 15
IS 6
BP 499
EP 504
DI 10.3109/15622975.2013.862345
PG 6
WC Psychiatry
SC Psychiatry
GA AN3GM
UT WOS:000340473900009
PM 24286278
ER

PT J
AU von Morgenstern, SB
   Becker, I
   Sinzig, J
AF von Morgenstern, Sophie Beyer
   Becker, Ingrid
   Sinzig, Judith
TI Improvement of facial affect recognition in children and adolescents
   with attention-deficit/hyperactivity disorder under methylphenidate
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE ADHD; affect recognition; facial affect recognition; methylphenidate
ID DEFICIT HYPERACTIVITY DISORDER; HIGH-FUNCTIONING ADULTS; EMOTIONAL
   EXPRESSIONS; ENDOPHENOTYPE CONCEPT; ADHD; DOPAMINE; AUTISM; MIND; GENE;
   PREVALENCE
AB Introduction and Hypothesis: Some authors draw a connection between the dopaminergic pathways and emotional perception. The present study is based on that association and addresses the question whether methylphenidate and the resulting amelioration of the disturbed dopamine metabolism lead to an improvement of the facial affect recognition abilities in children with attention-deficit/hyperactivity disorder (ADHD).
   Methods: A computer test was conducted on 21 participants, aged 7-14 years and with a diagnosis of ADHD - some with comorbid oppositional defiant disorder - conducted the FEFA (Frankfurt Test and Training of Facial Affect), a computer test to examine their facial affect recognition abilities. It consists of two subtests, one with faces and one with eye pairs. All participants were tested in a double-blind cross-over study, once under placebo and once under methylphenidate.
   Results and Discussion: The collected data showed that methylphenidate leads to amelioration of facial affect recognition abilities, but not on a significant level. Reasons for missing significance may be the small sample size or the fact that there exists some overlapping in cerebral connections and metabolic pathways of the site of action of methylphenidate and the affected dopaminergic areas in ADHD. However, consistent with the endophenotype concept, certain gene locations of the dopaminergic metabolism as both an aetiological factor for ADHD and the deficient facial affect recognition abilities with these individuals were considered. Consulting current literature they were found to be not concordant. Therefore, we conclude that the lacking significance of the methylphenidate affect on facial affect recognition is based on this fact.
C1 [von Morgenstern, Sophie Beyer] Childrens Hosp Dritter Orden, Dept Paediat Surg, Munich, Germany.
   [Becker, Ingrid] Univ Cologne, Inst Med Stat Informat & Epidemiol, Munich, Germany.
   [Sinzig, Judith] LVR Hosp Bonn, Dept Child & Adolescent Psychiat & Psychotherapy, Bonn, Germany.
RP von Morgenstern, SB (reprint author), Univ Cologne, Dept Child & Adolescent Psychiat & Psychotherapy, Munich, Germany.
EM sophiemorgenstern@hotmail.com
CR Abu-Akel A, 2003, MED HYPOTHESES, V60, P382, DOI 10.1016/S0306-9877(02)00406-1
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Boelte S, 2002, INT J CIRCUMPOLAR S2, V61, P61
   BOROD JC, 1986, NEUROPSYCHOLOGIA, V24, P169
   BOWERS D, 1991, BRAIN, V114, P2593, DOI 10.1093/brain/114.6.2593
   Breuer D, 2006, Z KINDER JUG-PSYCH, V34, P357, DOI 10.1024/1422-4917.34.5.357
   Buitelaar JK, 1999, DEV PSYCHOPATHOL, V11, P39, DOI 10.1017/S0954579499001947
   Faraone SV, 2001, AM J PSYCHIAT, V158, P1052, DOI 10.1176/appi.ajp.158.7.1052
   Flint J, 2007, PSYCHOL MED, V37, P163, DOI 10.1017/S0033291706008750
   Gatley S J, 1996, Life Sci, V58, P231
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Grady DL, 2005, AM J MED GENET B, V136B, P33, DOI 10.1002/ajmg.b.30182
   Harciarek M, 2009, J CLIN EXP NEUROPSYC, V31, P322, DOI 10.1080/13803390802119930
   Huck NO, 2008, INT J NEUROSCI, V118, P487, DOI 10.1080/00207450601125907
   Humphreys K, 2007, NEUROPSYCHOLOGIA, V45, P685, DOI 10.1016/j.neuropsychologia.2006.08.003
   Huss M, 2008, EUR CHILD ADOLES PSY, V17, P52, DOI 10.1007/s00787-008-1006-z
   Jones B, 2003, DESIGN ANAL CROSS OV, V2nd
   Kats-Gold I, 2007, J ABNORM CHILD PSYCH, V35, P363, DOI 10.1007/s10802-006-9096-x
   Kuczenski R, 1997, J NEUROCHEM, V68, P2032
   Lackner C, 2012, DEVELOPMENTAL SCI, V15, P272, DOI 10.1111/j.1467-7687.2011.01124.x
   Ludolph AG, 2008, NEUROIMAGE, V41, P718, DOI 10.1016/j.neuroimage.2008.02.025
   MCALPINE C, 1992, BEHAV MODIF, V16, P543, DOI 10.1177/01454455920164006
   Jensen PS, 1999, ARCH GEN PSYCHIAT, V56, P1073
   Premack D., 1978, BEHAVIORAL BRAIN SCI, V4, P515, DOI [10.1017/S0140525X00076512, DOI 10.1017/S0140525X00076512]
   Ramtekkar UP, 2010, J AM ACAD CHILD PSY, V49, P217, DOI 10.1016/j.jaac.2009.11.011
   Rubia K, 2009, NEUROPHARMACOLOGY, V57, P640, DOI 10.1016/j.neuropharm.2009.08.013
   Salgado-Pineda P, 2005, CLIN NEUROPHARMACOL, V28, P228, DOI 10.1097/01.wnf.0000185824.57690.f0
   Scheres A, 2003, J ABNORM CHILD PSYCH, V31, P105, DOI 10.1023/A:1021729501230
   Sinzig J, 2008, EUR CHILD ADOLES PSY, V17, P63, DOI 10.1007/s00787-007-0637-9
   Skounti M, 2007, EUR J PEDIATR, V166, P117, DOI 10.1007/s00431-006-0299-5
   Volkow ND, 2001, J NEUROSCI, V21, P1
   Williams LM, 2008, BIOL PSYCHIAT, V63, P917, DOI 10.1016/j.biopsych.2007.11.022
   World Health Organisation, 1992, INT STAT CLASS DIS R
   Zhu B, 2012, NEUROPSYCHOBIOLOGY, V65, P83, DOI 10.1159/000329555
   Zobel A, 2004, NERVENARZT, V75, P205, DOI 10.1007/s00115-003-1642-y
NR 35
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1601-5215
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD AUG
PY 2014
VL 26
IS 4
BP 202
EP 208
DI 10.1017/neu.2013.55
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AM8DR
UT WOS:000340101300002
ER

PT J
AU Kyriakopoulou, V
   Vatansever, D
   Elkommos, S
   Dawson, S
   McGuinness, A
   Allsop, J
   Molnar, Z
   Hajnal, J
   Rutherford, M
AF Kyriakopoulou, Vanessa
   Vatansever, Deniz
   Elkommos, Samia
   Dawson, Sarah
   McGuinness, Amy
   Allsop, Joanna
   Molnar, Zoltan
   Hajnal, Joseph
   Rutherford, Mary
TI Cortical Overgrowth in Fetuses With Isolated Ventriculomegaly
SO CEREBRAL CORTEX
LA English
DT Article
DE brain; development; magnetic resonance imaging
ID PROGRAMMED CELL-DEATH; IN-UTERO; BRAIN-DEVELOPMENT; GROWTH-PATTERNS;
   HUMAN NEOCORTEX; FETAL; CHILDREN; AUTISM; CORTEX; VOLUME
AB Mild cerebral ventricular enlargement is associated with schizophrenia, autism, epilepsy, and attention-deficit/hyperactivity disorder. Fetal ventriculomegaly is the most common central nervous system (CNS) abnormality affecting 1% of fetuses and is associated with cognitive, language, and behavioral impairments in childhood. Neurodevelopmental outcome is partially predictable by the 2-dimensional size of the ventricles in the absence of other abnormalities. We hypothesized that isolated fetal ventriculomegaly is a marker of altered brain development characterized by relative overgrowth and aimed to quantify brain growth using volumetric magnetic resonance imaging (MRI) in fetuses with isolated ventriculomegaly. Fetal brain MRI (1.5 T) was performed in 60 normal fetuses and 65 with isolated ventriculomegaly, across a gestational age range of 22-38 weeks. Volumetric analysis of the ventricles and supratentorial brain structures was performed on 3-dimensional reconstructed datasets. Fetuses with isolated ventriculomegaly had increased brain parenchyma volumes when compared with the control cohort (9.6%, P < 0.0001) with enlargement restricted to the cortical gray matter (17.2%, P = 0.002). The extracerebral cerebrospinal fluid and third and fourth ventricles were also enlarged. White matter, basal ganglia, and thalamic volumes were not significantly different between cohorts. The presence of relative cortical overgrowth in fetuses with ventriculomegaly may represent the neurobiological substrate for cognitive, language, and behavioral deficits in these children.
C1 [Kyriakopoulou, Vanessa; Allsop, Joanna; Hajnal, Joseph; Rutherford, Mary] Kings Coll London, St Thomas Hosp, Ctr Developing Brain Perinatal Imaging & Hlth, London SE1 7EH, England.
   [Kyriakopoulou, Vanessa; Vatansever, Deniz; Elkommos, Samia; Dawson, Sarah; McGuinness, Amy; Allsop, Joanna; Hajnal, Joseph; Rutherford, Mary] Kings Coll London, Hammersmith Hosp, Ctr Developing Brain, London SE1 7EH, England.
   [Molnar, Zoltan] Univ Oxford, Dept Physiol Anat & Genet, Oxford, England.
RP Rutherford, M (reprint author), Kings Coll London, St Thomas Hosp, Ctr Developing Brain Perinatal Imaging & Hlth, 1st Floor South Wing, London SE1 7EH, England.
EM mary.rutherford@kcl.ac.uk
FU Medical Research Council (UK); Biomedical Research Centre
FX This work was supported by the Medical Research Council (UK) and the
   Biomedical Research Centre.
CR Almog B, 2003, J ULTRAS MED, V22, P39
   CARDOZA JD, 1988, RADIOLOGY, V169, P711
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Chan WY, 2002, ANAT REC, V267, P261, DOI 10.1002/ar.10100
   Chenn A, 2002, SCIENCE, V297, P365, DOI 10.1126/science.1074192
   Clouchoux C, 2011, AM J OBSTET GYNECOL, V206, P173
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Depaepe V, 2005, NATURE, V435, P1244, DOI 10.1038/nature03651
   Eyles D, 2003, NEUROSCIENCE, V118, P641, DOI 10.1016/S0306-4522(03)00040-X
   Gaglioti P, 2009, PRENATAL DIAG, V29, P381, DOI 10.1002/pd.2195
   Garel C, 2003, CHILD NERV SYST, V19, P517, DOI 10.1007/s00381-003-0795-0
   Gilmore JH, 2008, BIOL PSYCHIAT, V64, P1069, DOI 10.1016/j.biopsych.2008.07.031
   Grossman R, 2006, NEUROIMAGE, V33, P463, DOI 10.1016/j.neuroimage.2006.07.005
   Hansen DV, 2010, NATURE, V464, P554, DOI 10.1038/nature08845
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Malinger G, 2007, ULTRASOUND OBST GYN, V29, P109, DOI 10.1002/uog.3909
   Jackson DC, 2011, EPILEPSIA, V52, P2225, DOI 10.1111/j.1528-1167.2011.03323.x
   Jiang SZ, 2007, IEEE T MED IMAGING, V26, P967, DOI 10.1109/TMI.2007.895456
   KALIFA GL, 1987, RADIOLOGY, V165, P29
   Kapellou O, 2006, PLOS MED, V3, P1382, DOI 10.1371/journal.pmed.0030265
   Kazan-Tannus JF, 2007, AM J ROENTGENOL, V189, P145, DOI 10.2214/AJR.07.2073
   Kelly EN, 2001, PRENATAL DIAG, V21, P697, DOI 10.1002/pd.138
   Kuan CY, 2000, TRENDS NEUROSCI, V23, P291, DOI 10.1016/S0166-2236(00)01581-2
   Leitner Y, 2009, AM J OBSTET GYNECOL, V201
   Leventopoulos G, 2009, PEDIATR NEUROL, V40, P357, DOI 10.1016/j.pediatrneurol.2008.11.013
   Lyall AE, 2012, EARLY HUM DEV, V88, P691, DOI 10.1016/j.earlhumdev.2012.02.003
   Lyoo IK, 1996, BIOL PSYCHIAT, V40, P1060
   Mehta TS, 2005, SEMIN FETAL NEONAT M, V10, P421, DOI 10.1016/j.siny.2005.05.002
   Melchiorre K, 2009, ULTRASOUND OBST GYN, V34, P212, DOI 10.1002/uog.7307
   Moore BD, 2000, NEUROLOGY, V54, P914
   Oppenheim RW, 2001, J NEUROSCI, V21, P4752
   Palmen SJMC, 2005, PSYCHOL MED, V35, P561, DOI 10.1017/S0033291704003496
   Peterson BS, 2000, JAMA-J AM MED ASSOC, V284, P1939, DOI 10.1001/jama.284.15.1939
   Pier DB, 2011, J ULTRAS MED, V30, P595
   Rajagopalan V, 2011, J NEUROSCI, V31, P2878, DOI 10.1523/JNEUROSCI.5458-10.2011
   Sadan S, 2007, BJOG-INT J OBSTET GY, V114, P596, DOI 10.1111/j.1471-0528.2007.01301.x
   Scott JA, 2011, INT J DEV NEUROSCI, V29, P529, DOI 10.1016/j.ijdevneu.2011.04.001
   Scott JA, 2012, BRAIN STRUCT FUNCT
   Smart IHM, 2002, CEREB CORTEX, V12, P37, DOI 10.1093/cercor/12.1.37
   SNIJDERS RJM, 1994, ULTRASOUND OBST GYN, V4, P34, DOI 10.1046/j.1469-0705.1994.04010034.x
   Tolsa CB, 2004, PEDIATR RES, V56, P132, DOI 10.1203/01.PDR.0000128983.54614.7E
   Wright IC, 2000, AM J PSYCHIAT, V157, P16
   Wyldes M, 2004, ARCH DIS CHILD, V89, pF9, DOI 10.1136/fn.89.1.F9
   Yushkevich PA, 2006, NEUROIMAGE, V31, P1116, DOI 10.1016/j.neuroimage.2006.01.015
   Zecevic N, 2001, J NEUROSCI, V21, P5607
NR 47
TC 1
Z9 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD AUG
PY 2014
VL 24
IS 8
BP 2141
EP 2150
DI 10.1093/cercor/bht062
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AM7SL
UT WOS:000340068500015
PM 23508710
ER

PT J
AU Spotorno, N
   Noveck, IA
AF Spotorno, Nicola
   Noveck, Ira A.
TI When Is Irony Effortful?
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
LA English
DT Article
DE attitude ascription; language processing; mindreading
ID SPECTRUM QUOTIENT AQ; AUTISM; MIND; METAANALYSIS; COGNITION; CONTEXT;
   SAMPLE; BRAIN; SAID
AB Whereas some studies indicate that ironic- as opposed to literal - readings of utterances take longer to process, others indicate that the 2 are processed at comparable speeds. We propose that mindreading processes are at least partly responsible for the mixed results, as we present 3 experiments that include stories having a target utterance with either an Ironic or Literal reading. Experiment 1 replicates earlier findings (Spotorno, Koun, Prado, Van Der Henst, & Noveck, 2012) showing that ironic readings take longer than literal ones when fillers include decoys, stories that call for an ironic remark but present a banal utterance instead and thus diffuse participants' expectations for irony. Starting with Experiment 2, decoys are removed, leading to effects that are arguably revealing of Theory of Mind processes. One is an Early-Late effect, which occurs when ironic utterances are read as readily as literal ones in the 2nd half of an experimental session, creating "mixed" results in the laboratory. In Experiment 3, we further added antecedents before a critical event so that, later, the target utterance would be echoing an explicitly stated thought and would facilitate irony comprehension (Gibbs, 1986; Sperber & Wilson, 1981). Results reveal an Early-Late effect here, too. Further evidence of Theory of Mind activity follows from analyses of participants' Social Skill subscale scores in the Autism-Spectrum Quotient (Baron-Cohen, Wheelwright, Skinner, Martin, & Clubley, 2001). Socially inclined participants are more likely than the socially disinclined to use a story's negative event to portend the arrival of an irony; in contrast, socially disinclined participants appear more reactive than the socially inclined to explicit antecedents.
C1 [Spotorno, Nicola; Noveck, Ira A.] Univ Lyon 1, CNRS, L2C2, F-69622 Villeurbanne, France.
   [Noveck, Ira A.] CRFJ, Jerusalem, Israel.
RP Spotorno, N (reprint author), Univ Penn, Perelman Sch Med, Penn Frontotemporal Degenerat Ctr, 3 West Gates,3400 Spruce St, Philadelphia, PA 19104 USA.
EM spotorno@mail.med.upenn.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Astington JW, 2002, NEW IDEAS PSYCHOL, V20, P131, DOI 10.1016/S0732-118X(02)00005-3
   Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
   Banerjee R, 2000, BRIT J DEV PSYCHOL, V18, P499, DOI 10.1348/026151000165823
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Filik R, 2010, COGNITION, V116, P421, DOI 10.1016/j.cognition.2010.06.005
   Filippova E, 2008, CHILD DEV, V79, P126, DOI 10.1111/j.1467-8624.2007.01115.x
   Frith CD, 2006, NEURON, V50, P531, DOI 10.1016/j.neuron.2006.05.001
   CLARK HH, 1984, J EXP PSYCHOL GEN, V113, P121, DOI 10.1037/0096-3445.113.1.121
   Gibbs Jr R. W., 2000, METAPHOR SYMBOL, V15, P5, DOI [DOI 10.1080/10926488.2000.9678862, DOI 10.1207/S15327868MS151&]
   Gibbs R. W., 1994, POETICS MIND FIGURAT
   Gibbs RW, 2002, J PRAGMATICS, V34, P457, DOI 10.1016/S0378-2166(01)00046-7
   Gibbs RW, 1997, COGNITION, V62, P51, DOI 10.1016/S0010-0277(96)00724-X
   GIBBS RW, 1986, J EXP PSYCHOL GEN, V115, P3, DOI 10.1037/0096-3445.115.1.3
   GIORA R, 1995, DISCOURSE PROCESS, V19, P239
   Giora R, 2007, METAPHOR SYMBOL, V22, P119
   Giora R, 2009, APPL COGN LINGUIST, V10, P383
   Giora R., 2009, PRAGMATICS ENCY, P265
   Giora R., 1997, COGN LINGUIST, V7, P183, DOI 10.1515/cogl.1997.8.3.183
   Giora Rachel, 1999, METAPHOR SYMBOL, V14, P241, DOI 10.1207/S15327868MS1404_1
   Grice P., 1989, STUDIES WAY WORDS
   Grodner D., 2012, CUNY SENT PROC C NEW
   Hagoort P, 2005, TRENDS COGN SCI, V9, P416, DOI 10.1016/j.tics.2006.07.004
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Howell D. C., 1997, STAT METHODS PSYCHOL
   Hurst RM, 2007, PERS INDIV DIFFER, V43, P1938, DOI 10.1016/j.paid.2007.06.012
   Hurst RM, 2007, J AUTISM DEV DISORD, V37, P1711, DOI 10.1007/s10803-006-0302-z
   Ivanko SL, 2003, DISCOURSE PROCESS, V35, P241, DOI 10.1207/S15326950DP3503_2
   JORGENSEN J, 1984, J EXP PSYCHOL GEN, V113, P112, DOI 10.1037//0096-3445.113.1.112
   Katz AN, 2005, FIGURATIVE LANGUAGE COMPREHENSION: SOCIAL AND CULTURAL INFLUENCES, P183
   Katz AN, 2004, CURR DIR PSYCHOL SCI, V13, P186, DOI 10.1111/j.0963-7214.2004.00304.x
   Lucariello J, 1995, COGNITIVE DEV, V10, P551, DOI 10.1016/0885-2014(95)90026-8
   Ma N, 2011, SOC NEUROSCI-UK, V6, P123, DOI 10.1080/17470919.2010.485884
   Nieuwland MS, 2010, J MEM LANG, V63, P324, DOI 10.1016/j.jml.2010.06.005
   Pexman PM, 2000, DISCOURSE PROCESS, V29, P201, DOI 10.1207/S15326950dp2903_2
   Pexman PM, 2008, CURR DIR PSYCHOL SCI, V17, P286, DOI 10.1111/j.1467-8721.2008.00591.x
   Saxe R, 2003, NEUROIMAGE, V19, P1835, DOI 10.1016/S1053-8119(03)00230-1
   Schwoebel John, 2000, METAPHOR SYMBOL, V15, P47, DOI [DOI 10.1080/10926488.2000.9678864, 10.1080/10926488.2000.9678864]
   Sonié Sandrine, 2011, Presse Med, V40, pe181, DOI 10.1016/j.lpm.2010.07.016
   Sperber D., 1986, RELEVANCE COMMUNICAT
   Sperber D., 1981, RADICAL PRAGMATICS, P295
   Spotorno N, 2012, NEUROIMAGE, V63, P25, DOI 10.1016/j.neuroimage.2012.06.046
   Spotorno N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066839
   Van Overwalle F, 2009, HUM BRAIN MAPP, V30, P829, DOI 10.1002/hbm.20547
   Van Overwalle F, 2009, NEUROIMAGE, V48, P564, DOI 10.1016/j.neuroimage.2009.06.009
   Wilson D., 2009, UCL WORKING PAPERS L, V21, P183
   Wilson Deirdre, 2012, MEANING RELEVANCE, P123, DOI [DOI 10.1017/CBO9781139028370.008, 10.1017/CBO9781139028370.008]
NR 47
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-3445
EI 1939-2222
J9 J EXP PSYCHOL GEN
JI J. Exp. Psychol.-Gen.
PD AUG
PY 2014
VL 143
IS 4
BP 1649
EP 1665
DI 10.1037/a0036630
PG 17
WC Psychology, Experimental
SC Psychology
GA AN0TF
UT WOS:000340296200017
PM 24773194
ER

PT J
AU Green, S
   Caplan, B
   Baker, B
AF Green, S.
   Caplan, B.
   Baker, B.
TI Maternal supportive and interfering control as predictors of adaptive
   and social development in children with and without developmental delays
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE control; developmental disabilities; interference; parenting
ID BEHAVIOR PROBLEMS; YOUNG-CHILDREN; INTELLECTUAL DISABILITY; PARENTING
   STRESS; COMPETENCE; DIRECTIVENESS; LANGUAGE; INFANTS; MOTHERS; AUTISM
AB Background Parents of children with developmental delays (DD) have been found to use more controlling behaviour with their children than parents of children with typical development (TD). While controlling behaviour is related to poorer developmental outcomes in TD children, there is little research on how it predicts outcomes in DD children. Furthermore, existing research tends to use inconsistent or non-specific definitions of controlling behaviour, often combining parent control which follows the child's goal (e. g. supportive direction) and that which interferes with the child's goal (e. g. interference).
   Methods Participants were 200 mother-child dyads observed at child age 3, with follow-up assessments of adaptive behaviour and social skills administered at child ages 5 and 6, respectively. We coded the frequency of both types of controlling behaviour based on mothers' interactions with their children with TD (n = 113) or DD (n = 87) at age 3.
   Results Mothers in the DD group used more interfering but not more supportive directive acts compared to mothers in the TD group. Adaptive behaviour was assessed at child age 5 and social skills were assessed at age 6. Higher frequency of supportive directive acts predicted better adaptive functioning for the TD group and better social skills for the DD group. Higher frequency of interfering acts predicted lower adaptive and social skills for children with DD but not with TD.
   Conclusions Results are discussed in terms of the differential developmental needs of children with and without DD as well as implications for early intervention.
C1 [Green, S.; Caplan, B.; Baker, B.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90025 USA.
RP Green, S (reprint author), Univ Calif Los Angeles, Los Angeles, CA 90025 USA.
EM shulamite@ucla.edu
CR Achenbach T. M., 2000, MANUAL CHILD BEHAV C
   Baker BL, 2002, AM J MENT RETARD, V107, P433, DOI 10.1352/0895-8017(2002)107<0433:BPAPSI>2.0.CO;2
   Baker BL, 2003, J INTELL DISABIL RES, V47, P217, DOI 10.1046/j.1365-2788.2003.00484.x
   Baker JK, 2010, J AUTISM DEV DISORD, V40, P988, DOI 10.1007/s10803-010-0948-4
   Baker JK, 2007, AM J MENT RETARD, V112, P375, DOI 10.1352/0895-8017(2007)112[0375:POSSIY]2.0.CO;2
   Bayley N, 1993, BAYLEY SCALES INFANT
   BROOKSGUNN J, 1984, CHILD DEV, V55, P782, DOI 10.1111/j.1467-8624.1984.tb03815.x
   Carson JL, 1996, CHILD DEV, V67, P2217, DOI 10.1111/j.1467-8624.1996.tb01853.x
   CIELINSKI KL, 1995, INFANT BEHAV DEV, V18, P163, DOI 10.1016/0163-6383(95)90046-2
   Crnic K, 2004, INFANT YOUNG CHILD, V17, P223
   CRNIC KA, 1983, CHILD DEV, V54, P1199, DOI 10.1111/j.1467-8624.1983.tb00540.x
   DECI EL, 1993, J EXP CHILD PSYCHOL, V55, P151, DOI 10.1006/jecp.1993.1008
   Eisenberg N, 2001, DEV PSYCHOL, V37, P475, DOI 10.1037//0012-1649.37.4.475
   Eyberg S. M., 1988, CHILD FAM BEHAV THER, V10, P33, DOI DOI 10.1300/J019V10N01_04
   Fenton G, 2003, AUTISM, V7, P269, DOI 10.1177/1362361303007003004
   Flynn V, 2007, J CHILD LANG, V34, P519, DOI 10.1017/S030500090700801X
   Gerstein ED, 2011, J ABNORM CHILD PSYCH, V39, P351, DOI 10.1007/s10802-010-9471-5
   Gilmore L, 2009, RES DEV DISABIL, V30, P1023, DOI 10.1016/j.ridd.2009.02.005
   Gresham F. M., 1990, SOCIAL SKILLS RATING
   Guralnick M. J., 1997, EFFECTIVENESS EARLY, P579
   Guralnick MJ, 2003, AM J MENT RETARD, V108, P272, DOI 10.1352/0895-8017(2003)108<272:FFAWTP>2.0.CO;2
   Guralnick MJ, 1999, MENT RETARD DEV D R, V5, P21
   Guralnick MJ, 2007, CHILD DEV, V78, P459, DOI 10.1111/j.1467-8624.2007.01009.x
   Herman M., 1983, J APPL DEV PSYCHOL, V4, P217, DOI 10.1016/0193-3973(83)90019-9
   Ispa JM, 2004, CHILD DEV, V75, P1613, DOI 10.1111/j.1467-8624.2004.00806.x
   Joussemet M, 2008, CHILD DEV, V79, P411, DOI 10.1111/j.1467-8624.2007.01133.x
   KEITH TZ, 1987, J SCHOOL PSYCHOL, V25, P31, DOI 10.1016/0022-4405(87)90058-6
   Laing SR, 2010, EARLY HUM DEV, V86, P793, DOI 10.1016/j.earlhumdev.2010.08.025
   Landry A. H., 2000, CHILD DEV, V<IT>71</IT>, P358
   Leerkes EM, 2009, CHILD DEV, V80, P762, DOI 10.1111/j.1467-8624.2009.01296.x
   Liss M, 2001, J AUTISM DEV DISORD, V31, P219, DOI 10.1023/A:1010707417274
   MARFO K, 1990, J CHILD PSYCHOL PSYC, V31, P531, DOI 10.1111/j.1469-7610.1990.tb00796.x
   Marfo K., 1991, EARLY INTERVENTION T, P177
   MARFO K, 1992, AM J ORTHOPSYCHIAT, V62, P219, DOI 10.1037/h0079334
   McDowell D., 2005, SOCIAL DEV, V<IT>9</IT>, P415
   McIntyre LL, 2006, J INTELL DISABIL RES, V50, P349, DOI 10.1111/j.1365-2788.2006.00783.x
   Nader-Grosbois N, 2012, RES DEV DISABIL, V33, P449, DOI 10.1016/j.ridd.2011.10.005
   NEWCOMB AF, 1993, PSYCHOL BULL, V113, P99, DOI 10.1037//0033-2909.113.1.99
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   Smith KE, 1996, J CHILD PSYCHOL PSYC, V37, P855, DOI 10.1111/j.1469-7610.1996.tb01481.x
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
   Warren SF, 2010, AJIDD-AM J INTELLECT, V115, P54, DOI 10.1352/1944-7558-115.1.54
   WEBSTERSTRATTON C, 1982, J CLIN CHILD PSYCHOL, V11, P123, DOI 10.1207/s15374424jccp1102_5
   Yoder PJ, 2001, AM J MENT RETARD, V106, P327, DOI 10.1352/0895-8017(2001)106<0327:ICELFM>2.0.CO;2
NR 46
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD AUG
PY 2014
VL 58
IS 8
BP 691
EP 703
DI 10.1111/jir.12064
PG 13
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA AM7ZI
UT WOS:000340087100001
PM 23865770
ER

PT J
AU Janes, E
   Riby, DM
   Rodgers, J
AF Janes, E.
   Riby, D. M.
   Rodgers, J.
TI Exploring the prevalence and phenomenology of repetitive behaviours and
   abnormal sensory processing in children with Williams Syndrome
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE repetitive and restricted behaviours; sensory processing abnormalities;
   Williams Syndrome
ID AUTISM SPECTRUM DISORDERS; HYPERACUSIS; INTERVIEW; PHENOTYPE; ANXIETY;
   ADULTS; FEARS
AB Background A small amount of research with individuals who have Williams Syndrome (WS) suggests that children with the condition may be vulnerable to sensory processing abnormalities and present with repetitive and restricted behaviours.
   Methods Parents of 21 children with WS aged 6-15 years completed a semi-structured interview designed to elicit the form, frequency, impact and developmental course of a range of sensory processing abnormalities and repetitive behaviours.
   Results Findings indicate that sensory processing difficulties are predominantly characterised by hypersensitivities, particularly in relation to vestibular, auditory, gustatory and proprioceptive functioning. Parents also reported the presence of a range of restricted and repetitive behaviours, which were often associated with their child's sensory symptoms.
   Conclusions This study makes a significant contribution to our understanding of sensory functioning and repetitive behaviours in WS. It also highlights the need for a multidisciplinary assessment of the difficulties experienced by children with the disorder.
C1 [Janes, E.; Rodgers, J.] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   [Riby, D. M.] Univ Durham, Sch Psychol, Durham, Tyne & Wear, England.
RP Rodgers, J (reprint author), Newcastle Univ, Inst Neurosci, Ridley Bldg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
EM jacqui.rodgers@newcastle.ac.uk
CR Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
   Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
   Blomberg S, 2006, RES DEV DISABIL, V27, P668, DOI 10.1016/j.ridd.2005.09.002
   Bogdashina O, 2003, SENSORY PERCEPTUAL I
   Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6
   Davies M, 1998, BRIT J PSYCHIAT, V172, P273, DOI 10.1192/bjp.172.3.273
   Dilts C V, 1990, Am J Med Genet Suppl, V6, P126
   Dunn W, 1999, SENSORY PROFILE USER
   Dykens EM, 2003, DEV NEUROPSYCHOL, V23, P291, DOI 10.1207/S15326942DN231&2_13
   Gabriels R. L., 2005, U COL DENV HLTH SCI
   Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
   Gallo FJ, 2008, RES DEV DISABIL, V29, P567, DOI 10.1016/j.ridd.2007.09.003
   GOSCH A, 1994, AM J MED GENET, V53, P335, DOI 10.1002/ajmg.1320530406
   Honey E, 2012, RES AUTISM SPECT DIS, V6, P757, DOI 10.1016/j.rasd.2011.10.011
   Janes E. V., 2010, SENSORY PROCES UNPUB
   John A. E., 2010, AM J MED GENET C, V154C, P229
   Joosten AV, 2009, J AUTISM DEV DISORD, V39, P521, DOI 10.1007/s10803-008-0654-7
   Korenberg J. R., 2003, NATURE ENCY HUMAN GE, P757
   Levitin DJ, 2005, J CHILD PSYCHOL PSYC, V46, P514, DOI 10.1111/j.1469-7610.2004.00376.x
   Liss M, 2008, PERS INDIV DIFFER, V45, P255, DOI 10.1016/j.paid.2008.04.009
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Martens MA, 2008, J CHILD PSYCHOL PSYC, V49, P576, DOI 10.1111/j.1469-7610.2008.01887.x
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   Mervis CB, 2000, BRAIN COGNITION, V44, P604, DOI 10.1006/brcg.2000.1232
   Rhodes SM, 2011, J CLIN EXP NEUROPSYC, V33, P147, DOI 10.1080/13803395.2010.495057
   Riby D. M., 2012, J AUTISM DEV DISORD, V42, P175
   Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x
   Searcy YM, 2004, AM J MENT RETARD, V109, P231, DOI 10.1352/0895-8017(2004)109<231:TRBAAI>2.0.CO;2
   Semel E., 2003, UNDERSTANDING WILLIA
   Smith-Myles B., 2000, ASPERGER SYNDROME SE
   Turner M., 1997, EXECUTIVE FUNCTIONIN, P57
   UDWIN O, 1987, J CHILD PSYCHOL PSYC, V28, P297, DOI 10.1111/j.1469-7610.1987.tb00212.x
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
NR 33
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD AUG
PY 2014
VL 58
IS 8
BP 746
EP 757
DI 10.1111/jir.12086
PG 12
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA AM7ZI
UT WOS:000340087100005
PM 23962322
ER

PT J
AU Jamal, W
   Das, S
   Oprescu, IA
   Maharatna, K
   Apicella, F
   Sicca, F
AF Jamal, Wasifa
   Das, Saptarshi
   Oprescu, Ioana-Anastasia
   Maharatna, Koushik
   Apicella, Fabio
   Sicca, Federico
TI Classification of autism spectrum disorder using supervised learning of
   brain connectivity measures extracted from synchrostates
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
DE autism spectrum disorder (ASD); brain connectivity; complex network;
   classification; synchrostate
ID SMALL-WORLD NETWORKS; HEAD CIRCUMFERENCE; EEG; SYNCHRONIZATION; CORTEX
AB Objective. The paper investigates the presence of autism using the functional brain connectivity measures derived from electro-encephalogram (EEG) of children during face perception tasks. Approach. Phase synchronized patterns from 128-channel EEG signals are obtained for typical children and children with autism spectrum disorder (ASD). The phase synchronized states or synchrostates temporally switch amongst themselves as an underlying process for the completion of a particular cognitive task. We used 12 subjects in each group (ASD and typical) for analyzing their EEG while processing fearful, happy and neutral faces. The minimal and maximally occurring synchrostates for each subject are chosen for extraction of brain connectivity features, which are used for classification between these two groups of subjects. Among different supervised learning techniques, we here explored the discriminant analysis and support vector machine both with polynomial kernels for the classification task. Main results. The leave one out cross-validation of the classification algorithm gives 94.7% accuracy as the best performance with corresponding sensitivity and specificity values as 85.7% and 100% respectively. Significance. The proposed method gives high classification accuracies and outperforms other contemporary research results. The effectiveness of the proposed method for classification of autistic and typical children suggests the possibility of using it on a larger population to validate it for clinical practice.
C1 [Jamal, Wasifa; Das, Saptarshi; Oprescu, Ioana-Anastasia; Maharatna, Koushik] Univ Southampton, Sch Elect & Comp Sci, Southampton SO17 1BJ, Hants, England.
   [Apicella, Fabio; Sicca, Federico] IRCCS Stella Maris Fdn, Pisa, Calambrone, Italy.
RP Jamal, W (reprint author), Univ Southampton, Sch Elect & Comp Sci, Southampton SO17 1BJ, Hants, England.
EM wj4g08@ecs.soton.ac.uk; sd2a11@ecs.soton.ac.uk; io1g10@ecs.soton.ac.uk;
   km3@ecs.soton.ac.uk; fabio.apicella@fsm.unipi.it; fsicca@fsm.unipi.it
FU EU - MICHELANGELO project [288241]
FX The work presented in this paper was supported by FP7 EU funded
   MICHELANGELO project, Grant Agreement #288241. URL:
   www.michelangelo-project.eu/. We are grateful to Professor Filippo
   Muratori for his valuable suggestions on this paper.
CR Apicella F, 2013, BEHAV BRAIN RES, V251, P115
   Barrat A, 2004, P NATL ACAD SCI USA, V101, P3747, DOI 10.1073/pnas.0400087101
   Bassettt DS, 2006, P NATL ACAD SCI USA, V103, P19518, DOI 10.1073/pnas.0606005103
   Betzel R F, 2013, NETW SCI, V1, P353, DOI DOI 10.1017/NWS.2013.19
   Blankertz B, 2011, NEUROIMAGE, V56, P814, DOI 10.1016/j.neuroimage.2010.06.048
   Carver LJ, 2002, MOL PSYCHIATR, V7, pS18, DOI 10.1038/sj.mp.4001168
   Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Dimitriadis SI, 2013, NEUROIMAGE, V83, P307, DOI 10.1016/j.neuroimage.2013.06.036
   Engel AK, 2001, NAT REV NEUROSCI, V2, P704, DOI 10.1038/35094565
   Fries P, 2009, ANNU REV NEUROSCI, V32, P209, DOI 10.1146/annurev.neuro.051508.135603
   Garrett D, 2003, IEEE T NEUR SYS REH, V11, P141, DOI 10.1109/TNSRE.2003.814441
   GRAY CM, 1989, NATURE, V338, P334, DOI 10.1038/338334a0
   Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
   Jamal W., 2013, 35 ANN INT C IEEE EN, P2539
   Jamal W, 2013, I IEEE EMBS C NEUR E, P1402, DOI 10.1109/NER.2013.6696205
   Jrad N, 2011, J NEURAL ENG, V8, DOI 10.1088/1741-2560/8/5/056004
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kana RK, 2011, PHYS LIFE REV, V8, P410, DOI 10.1016/j.plrev.2011.10.001
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Lainhart JE, 2006, AM J MED GENET C, V142C, P33, DOI 10.1002/ajmg.c.30080
   Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
   Liao X, 2007, J NEURAL ENG, V4, P246, DOI 10.1088/1741-2560/4/3/010
   Liu Y, 2008, BRAIN, V131, P945, DOI 10.1093/brain/awn018
   Liyanage SR, 2013, J NEURAL ENG, V10, DOI 10.1088/1741-2560/10/3/036007
   Lotte F, 2007, J NEURAL ENG, V4, pR1, DOI 10.1088/1741-2560/4/R01
   Menon V, 1996, ELECTROEN CLIN NEURO, V98, P89, DOI 10.1016/0013-4694(95)00206-5
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Molinaro AM, 2005, BIOINFORMATICS, V21, P3301, DOI 10.1093/bioinformatics/bti499
   Mutlu AY, 2012, COMPUT MATH METHOD M, DOI 10.1155/2012/451516
   Newman MEJ, 2004, PHYS REV E, V70, DOI 10.1103/PhysRevE.70.056131
   Nunez PL, 1997, ELECTROEN CLIN NEURO, V103, P499, DOI 10.1016/S0013-4694(97)00066-7
   Pollonini L, 2010, IEEE ENG MED BIO, P1730, DOI 10.1109/IEMBS.2010.5626702
   Quiroga RQ, 2002, PHYS REV E, V65, DOI 10.1103/PhysRevE.65.041903
   Ramoser H, 2000, IEEE T REHABIL ENG, V8, P441, DOI 10.1109/86.895946
   Rapp Paul E, 2013, Front Neurol, V4, P177, DOI 10.3389/fneur.2013.00177
   Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
   Rodriguez E, 1999, NATURE, V397, P430
   Rogers Simon, 2011, 1 COURSE MACHINE LEA
   Rubinov M, 2010, NEUROIMAGE, V52, P1059, DOI 10.1016/j.neuroimage.2009.10.003
   Semmlow J L, 2009, BIOSIGNAL MED IMAGE
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Sporns O., 2011, NETWORKS BRAIN
   Stahl D, 2012, DEV NEUROPSYCHOL, V37, P274, DOI 10.1080/87565641.2011.650808
   Strogatz SH, 2001, NATURE, V410, P268, DOI 10.1038/35065725
   Supekar K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000157
   Supekar K, 2008, PLOS COMPUT BIOL, V4, DOI 10.1371/journal.pcbi.1000100
   Theodoridis S, 2010, INTRO PATTERN RECOGN
   Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, P1
   Watts DJ, 1998, NATURE, V393, P440, DOI 10.1038/30918
NR 50
TC 1
Z9 1
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD AUG
PY 2014
VL 11
IS 4
AR 046019
DI 10.1088/1741-2560/11/4/046019
PG 19
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA AM7KS
UT WOS:000340046500019
PM 24981017
ER

PT J
AU Dalrymple, KA
   Fletcher, K
   Corrow, S
   das Nair, R
   Barton, JJS
   Yonas, A
   Duchaine, B
AF Dalrymple, Kirsten A.
   Fletcher, Kimberley
   Corrow, Sherryse
   das Nair, Roshan
   Barton, Jason J. S.
   Yonas, Albert
   Duchaine, Brad
TI "A room full of strangers every day": The psychosocial impact of
   developmental prosopagnosia on children and their families
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Children; Developmental prosopagnosia; Face recognition; Psychosocial;
   Social development; Thematic analysis
ID AUTISM-SPECTRUM QUOTIENT; CONGENITAL PROSOPAGNOSIA; FACE RECOGNITION;
   VERSION
AB Objective: Individuals with developmental prosopagnosia ('face blindness') have severe face recognition difficulties due to a failure to develop the necessary visual mechanisms for recognizing faces. These difficulties occur in the absence of brain damage and despite normal low-level vision and intellect. Adults with developmental prosopagnosia report serious personal and emotional consequences from their inability to recognize faces, but little is known about the psychosocial consequences in childhood. Given the importance of face recognition in daily life, and the potential for unique social consequences of impaired face recognition in childhood, we sought to evaluate the impact of developmental prosopagnosia on children and their families.
   Methods: We conducted semi-structured interviews with 8 children with developmental prosopagnosia and their parents. A battery of face recognition tests was used to confirm the face recognition impairment reported by the parents of each child. We used thematic analysis to develop common themes among the psychosocial experiences of the children and their parents.
   Results: Three themes were developed from the child reports: 1) awareness of their difficulties, 2) coping strategies, such as using non-facial cues to identify others, and 3) social implications, such as discomfort in, and avoidance of, social situations. These themes were paralleled by the parent reports and highlight the unique social and practical challenges associated with childhood developmental prosopagnosia.
   Conclusion: Our findings indicate a need for increased awareness and treatment of developmental prosopagnosia to help these children manage their face recognition difficulties and to promote their social and emotional wellbeing. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Dalrymple, Kirsten A.; Duchaine, Brad] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA.
   [Dalrymple, Kirsten A.] UCL, Inst Cognit Neurosci, London, England.
   [Fletcher, Kimberley; Barton, Jason J. S.] Univ British Columbia, Dept Med Neurol, Vancouver, BC V5Z 1M9, Canada.
   [Fletcher, Kimberley; Barton, Jason J. S.] Univ British Columbia, Dept Ophthalmol & Visual Sci, Vancouver, BC V5Z 1M9, Canada.
   [Fletcher, Kimberley; Barton, Jason J. S.] Univ British Columbia, Dept Psychol, Vancouver, BC V5Z 1M9, Canada.
   [Corrow, Sherryse; Yonas, Albert] Univ Minnesota, Inst Child Dev, Minneapolis, MN 55455 USA.
   [das Nair, Roshan] Univ Nottingham, Div Rehabil & Ageing, Nottingham NG7 2RD, England.
RP Dalrymple, KA (reprint author), Univ Minnesota, Inst Child Dev, 51 East River Pkwy, Minneapolis, MN 55455 USA.
EM kad@umn.edu
RI Barton, Jason/A-6362-2012
FU Economic and Social Research Council (UK) [RES-062-23-2426]; CIHR
   operating grant [MOP-102567]; Eva O. Miller Fellowship; Doctoral
   Dissertation Fellowship through the graduate school of the University of
   Minnesota; Canada Research Chair grant [950-228984]; Marianne Koerner
   Chair in Brain Diseases
FX KAD and BD were supported by an Economic and Social Research Council
   (UK) grant (RES-062-23-2426) to BD. KF was supported through a CIHR
   operating grant (MOP-102567) to JJSB. SC was supported by the Eva O.
   Miller Fellowship and the Doctoral Dissertation Fellowship through the
   graduate school of the University of Minnesota. JJSB was supported by a
   Canada Research Chair grant (950-228984) and the Marianne Koerner Chair
   in Brain Diseases. We would like to thank all the children and families
   for their candid responses to our interview questions and for inviting
   us into their homes for lengthy assessments.
CR Andrade A, 2009, QUALITATIVE REPORT, V14, P42
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Behrmann M, 2005, TRENDS COGN SCI, V9, P180, DOI 10.1016/j.tics.2005.02.011
   Blacker R, 2009, THEMATIC ANAL PSYCHO
   Bowles DC, 2009, COGN NEUROPSYCHOL, V26, P423, DOI 10.1080/02643290903343149
   Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
   BRUCE V, 1986, BRIT J PSYCHOL, V77, P305
   Cohen M, 2011, RES METHODS ED
   Dalrymple KA, 2012, J VISION, V12, P492
   Dalrymple KA, 2012, COGN NEUROPSYCHOL, V29, P393, DOI 10.1080/02643294.2012.722547
   Dey I, 1991, GROUNDING GROUNDED T
   Diaz AL, 2008, J SCH NURS, V24, P284, DOI 10.1177/1059840508322381
   Duchaine BC, 2006, CURR OPIN NEUROBIOL, V16, P166, DOI 10.1016/j.conb.2006.03.003
   ECCLES JS, 1993, AM PSYCHOL, V48, P90, DOI 10.1037//0003-066X.48.2.90
   Glaser B., 1967, DISCOVERY GROUNDED T
   GOLDSTEIN AG, 1983, J NONVERBAL BEHAV, V7, P223, DOI 10.1007/BF00986268
   Kennerknecht I, 2006, AM J MED GENET A, V140A, P1607
   Kennerknecht I, 2008, AM J MED GENET A, V146A, P2863, DOI 10.1002/ajmg.a.32552
   Kress T, 2003, NEUROSCI LETT, V352, P133, DOI 10.1016/S0304-3940(03)01040-1
   Lincoln VS, 1986, NEW DIR PROGRAM EVAL, V1986, P73
   Roeser RW, 2000, ELEM SCHOOL J, V100, P443, DOI 10.1086/499650
   Wechsler D, 2011, WECHSLER ABBREVIATED, V2nd
   Wilhelm O, 2010, J PERS SOC PSYCHOL, V99, P530, DOI 10.1037/a0019972
   Yardley L, 2008, J PSYCHOSOM RES, V65, P445, DOI 10.1016/j.jpsychores.2008.03.013
   Yardley L, 2000, PSYCHOL HEALTH, V15, P215, DOI 10.1080/08870440008400302
NR 26
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD AUG
PY 2014
VL 77
IS 2
BP 144
EP 150
DI 10.1016/j.jpsychores.2014.06.001
PG 7
WC Psychiatry
SC Psychiatry
GA AM6YQ
UT WOS:000340012300010
PM 25077856
ER

PT J
AU Larsen, CA
   Howard, MT
AF Larsen, C. Aaron
   Howard, Michael T.
TI Conserved regions of the DMD 3 ' UTR regulate translation and mRNA
   abundance in cultured myotubes
SO NEUROMUSCULAR DISORDERS
LA English
DT Article
DE DMD; Duchenne muscular dystrophy; 3' UTR; 5' UTR; Translational control
ID DUCHENNE MUSCULAR-DYSTROPHY; AUTISM SPECTRUM DISORDER; AUG INITIATOR
   CODON; SKELETAL-MUSCLES; UNTRANSLATED REGION; MDX MICE; GLYCOPROTEIN
   COMPLEX; MAMMALIAN-CELLS; GENE-EXPRESSION; NONCODING RNAS
AB Duchenne muscular dystrophy (DMD), a severe muscle-wasting disease, is caused by mutations in the DMD gene, which encodes for the protein dystrophin. Its regulation is of therapeutic interest as even small changes in expression of functional dystrophin can significantly impact the severity of DMD. While tissue-specific distribution and transcriptional regulation of several DMD mRNA isoforms has been well characterized, the post-transcriptional regulation of dystrophin synthesis is not well understood. Here, we utilize qRTPCR and a quantitative dual-luciferase reporter assay to examine the effects of isoform specific DMD 5' UTRs and the highly conserved DMD 3' UTR on mRNA abundance and translational control of gene expression in C2C12 cells. The 5' UTRs were shown to initiate translation with low efficiency in both myoblasts and myotubes. Whereas, two large highly conserved elements in the 3' UTR, which overlap the previously described Lemaire A and D regions, increase mRNA levels and enhance translation upon differentiation of myoblasts into myotubes. The results presented here implicate an important role for DMD UTRs in dystrophin expression and delineate the cis-acting elements required for the myotube-specific regulation of steady-state mRNA levels and translational enhancer activity found in the DMD 3' UTR. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Larsen, C. Aaron; Howard, Michael T.] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
RP Howard, MT (reprint author), Eccles Inst Human Genet, Room 7110,15 N 2030 East, Salt Lake City, UT 84112 USA.
EM mhoward@genetics.utah.edu
FU National Institutes of Health [NS083884]
FX We thank Chris Anderson and Norma Wills for technical assistance, and
   Drs. Kevin Flanigan (Ohio State University) and Robert Weiss (University
   of Utah) for comments and suggestions on this work. This work was
   supported in part by the National Institutes of Health NS083884 to MTH.
CR Andreassi C, 2009, TRENDS CELL BIOL, V19, P465, DOI 10.1016/j.tcb.2009.06.001
   Barreau C, 2005, NUCLEIC ACIDS RES, V33, P7138, DOI 10.1093/nar/gki1012
   Barrett LW, 2012, CELL MOL LIFE SCI, V69, P3613, DOI 10.1007/s00018-012-0990-9
   Barton-Davis ER, 1999, J CLIN INVEST, V104, P375, DOI 10.1172/JCI7866
   Blake DJ, 2002, PHYSIOL REV, V82, P291, DOI 10.1152/physrev.00028.2001
   Bovolenta M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045328
   Cacchiarelli D, 2011, EMBO REP, V12, P136, DOI 10.1038/embor.2010.208
   Cesana M, 2011, CELL, V147, P358, DOI 10.1016/j.cell.2011.09.028
   Chakkalakal JV, 2008, NUCLEIC ACIDS RES, V36, P826, DOI 10.1093/nar/gkm1107
   Chatterjee S, 2009, BIOL CELL, V101, P251, DOI 10.1042/BC20080104
   Waterston RH, 2002, NATURE, V420, P520, DOI 10.1038/nature01262
   Cirak S, 2011, LANCET, V378, P595, DOI 10.1016/S0140-6736(11)60756-3
   Cohn RD, 2000, MUSCLE NERVE, V23, P1456, DOI 10.1002/1097-4598(200010)23:10<1456::AID-MUS2>3.0.CO;2-T
   Cotton SM, 2005, DEV MED CHILD NEUROL, V47, P257, DOI 10.1017/S0012162205000496
   Dassi E, 2013, NUCLEIC ACIDS RES, V41, P3201, DOI 10.1093/nar/gkt017
   Daubas P, 2009, DEV BIOL, V327, P71, DOI 10.1016/j.ydbio.2008.11.031
   de Brouwer APM, 2014, EUR J HUM GENET, V22, P480, DOI 10.1038/ejhg.2013.169
   Erriquez D, 2013, INT J MOL SCI, V14, P19681, DOI 10.3390/ijms141019681
   Fabb SA, 2002, HUM MOL GENET, V11, P733, DOI 10.1093/hmg/11.7.733
   Fairclough RJ, 2013, NAT REV GENET, V14, P373, DOI 10.1038/nrg3460
   Finkel RS, 2010, J CHILD NEUROL, V25, P1158, DOI 10.1177/0883073810371129
   Flanigan KM, 2011, HUM MUTAT, V32, P299, DOI 10.1002/humu.21426
   Flanigan KM, 2009, HUM MUTAT, V30, P1657, DOI 10.1002/humu.21114
   Forest D, 2007, P NATL ACAD SCI USA, V104, P1224, DOI 10.1073/pnas.0610350104
   Foster H, 2008, MOL THER, V16, P1825, DOI 10.1038/mt.2008.186
   Foster H, 2012, HUM GENE THER, V23, P676, DOI 10.1089/hum.2012.099
   Gingerich Timothy J., 2004, Animal Health Research Reviews, V5, P49, DOI 10.1079/AHRR200460
   Goemans NM, 2011, NEW ENGL J MED, V364, P1513, DOI 10.1056/NEJMoa1011367
   Gramolini AO, 2001, J CELL BIOL, V154, P1173, DOI 10.1083/jcb.200101108
   Greener MJ, 2002, EUR J HUM GENET, V10, P413, DOI 10.1038/sj.ejhg.5200822
   Gurvich OL, 2008, ANN NEUROL, V63, P81, DOI 10.1002/ana.21290
   Hendriksen JGM, 2008, J CHILD NEUROL, V23, P477, DOI 10.1177/0883073807309775
   Ho ES, 2011, GENOME BIOL EVOL, V3, P654, DOI 10.1093/gbe/evr053
   HOFFMAN EP, 1987, CELL, V51, P919, DOI 10.1016/0092-8674(87)90579-4
   Hogg JR, 2010, CELL, V143, P379, DOI 10.1016/j.cell.2010.10.005
   Howard MT, 2004, ANN NEUROL, V55, P422, DOI 10.1002/ana.20052
   Hube F, 2011, NUCLEIC ACIDS RES, V39, P513, DOI 10.1093/nar/gkq833
   Johnsson P, 2014, BBA-GEN SUBJECTS, V1840, P1063, DOI 10.1016/j.bbagen.2013.10.035
   Kanamori H, 1998, MOL CELL BIOL, V18, P3991
   Kinali M, 2009, LANCET NEUROL, V8, P918, DOI 10.1016/S1474-4422(09)70211-X
   Kochetov AV, 1998, FEBS LETT, V440, P351, DOI 10.1016/S0014-5793(98)01482-3
   KOENIG M, 1987, CELL, V50, P509, DOI 10.1016/0092-8674(87)90504-6
   Koo T, 2011, HUM GENE THER, V22, P1379, DOI 10.1089/hum.2011.020
   Koo T, 2011, J GENE MED, V13, P497, DOI 10.1002/jgm.1602
   Kozak M, 1997, EMBO J, V16, P2482, DOI 10.1093/emboj/16.9.2482
   KOZAK M, 1986, CELL, V44, P283, DOI 10.1016/0092-8674(86)90762-2
   KOZAK M, 1987, J MOL BIOL, V196, P947, DOI 10.1016/0022-2836(87)90418-9
   Kubokawa I, 2010, MOL VIS, V16, P2590
   LEMAIRE C, 1988, EMBO J, V7, P4157
   Lu QL, 2005, P NATL ACAD SCI USA, V102, P198, DOI 10.1073/pnas.040600102
   Malik V, 2010, ANN NEUROL, V67, P771, DOI 10.1002/ana.22024
   Matoulkova E, 2012, RNA BIOL, V9, P563, DOI 10.4161/rna.20231
   Mazumder B, 2003, TRENDS BIOCHEM SCI, V28, P91, DOI 10.1016/S0968-0004(02)00002-1
   MCCABE ERB, 1989, J CLIN INVEST, V83, P95, DOI 10.1172/JCI113890
   Mendell JR, 2013, ANN NEUROL, V74, P637, DOI 10.1002/ana.23982
   Mignone F., 2002, GENOME BIOL, V3, DOI DOI 10.1186/GB-2002-3-3-REVIEWS0004
   Miura P, 2010, HUM MOL GENET, V19, P1211, DOI 10.1093/hmg/ddp591
   Miura P, 2005, J BIOL CHEM, V280, P32997, DOI 10.1074/jbc.M503994200
   Monaco AP, 1988, GENOMICS, V2, P90, DOI 10.1016/0888-7543(88)90113-9
   Muir LA, 2009, EXPERT REV MOL MED, V11, DOI 10.1017/S1462399409001100
   Muntoni F, 2003, LANCET NEUROL, V2, P731, DOI 10.1016/S1474-4422(03)00585-4
   Pichavant C, 2011, MOL THER, V19, P830, DOI 10.1038/mt.2011.59
   Pickering BM, 2005, SEMIN CELL DEV BIOL, V16, P39, DOI 10.1016/j.semcdb.2004.11.006
   Rodino-Klapac LR, 2010, MOL THER, V18, P109, DOI 10.1038/mt.2009.254
   Sathirapongsasuti JF, 2011, NUCLEIC ACIDS RES, V39, P1967, DOI 10.1093/nar/gkq949
   Siepel A, 2005, GENOME RES, V15, P1034, DOI 10.1101/gr.3715005
   Spitali P, 2013, FASEB J, V27, P4909, DOI 10.1096/fj.13-232025
   Tanguay RL, 1996, MOL CELL BIOL, V16, P146
   van Putten M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031937
   van Deutekom JC, 2007, NEW ENGL J MED, V357, P2677, DOI 10.1056/NEJMoa073108
   van Putten M, 2013, FASEB J, V27, P2484, DOI 10.1096/fj.12-224170
   Waite A, 2012, TRENDS NEUROSCI, V35, P487, DOI 10.1016/j.tins.2012.04.004
   Waite A, 2009, ANN MED, V41, P344, DOI 10.1080/07853890802668522
   Wang B, 2000, P NATL ACAD SCI USA, V97, P13714, DOI 10.1073/pnas.240335297
   Wang ZJ, 2012, MOL THER, V20, P1501, DOI 10.1038/mt.2012.111
   Wang ZJ, 2007, MOL THER, V15, P1160, DOI 10.1038/sj.mt.6300161
   Wu JY, 2005, J CHILD NEUROL, V20, P790, DOI 10.1177/08830738050200100201
   Yoshida K, 1998, HUM MOL GENET, V7, P1129, DOI 10.1093/hmg/7.7.1129
NR 78
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-8966
EI 1873-2364
J9 NEUROMUSCULAR DISORD
JI Neuromusc. Disord.
PD AUG
PY 2014
VL 24
IS 8
BP 693
EP 706
DI 10.1016/j.nmd.2014.05.006
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AN1BH
UT WOS:000340317200007
PM 24928536
ER

PT J
AU Tansey, KE
   Rucker, JJH
   Kavanagh, DH
   Guipponi, M
   Perroud, N
   Bondolfi, G
   Domenici, E
   Evans, DM
   Hausers, J
   Henigsberg, N
   Jerman, B
   Maier, W
   Mors, O
   O'Donovan, M
   Peters, TJ
   Placentino, A
   Rietschel, M
   Souery, D
   Aitchison, KJ
   Craig, I
   Farmer, A
   Wendland, JR
   Malafosse, A
   Lewis, G
   Kapur, S
   McGuffin, P
   Uher, R
AF Tansey, K. E.
   Rucker, J. J. H.
   Kavanagh, D. H.
   Guipponi, M.
   Perroud, N.
   Bondolfi, G.
   Domenici, E.
   Evans, D. M.
   Hausers, J.
   Henigsberg, N.
   Jerman, B.
   Maier, W.
   Mors, O.
   O'Donovan, M.
   Peters, T. J.
   Placentino, A.
   Rietschel, M.
   Souery, D.
   Aitchison, K. J.
   Craig, I.
   Farmer, A.
   Wendland, J. R.
   Malafosse, A.
   Lewis, G.
   Kapur, S.
   McGuffin, P.
   Uher, R.
TI Copy number variants and therapeutic response to antidepressant
   medication in major depressive disorder
SO PHARMACOGENOMICS JOURNAL
LA English
DT Article
DE antidepressant; copy number variants; major depressive disorder;
   psychiatry; treatment response; 15q13.3
ID HIDDEN-MARKOV MODEL; SNP GENOTYPING DATA; DE-NOVO CNVS;
   BIPOLAR-DISORDER; SCHIZOPHRENIA; AUTISM; DUPLICATIONS; ASSOCIATION;
   DELETIONS
AB It would be beneficial to find genetic predictors of antidepressant response to help personalise treatment of major depressive disorder (MDD). Rare copy number variants (CNVs) have been implicated in several psychiatric disorders, including MDD, but their role in antidepressant response has yet to be investigated. CNV data were available for 1565 individuals with MDD from the NEWMEDS (Novel Methods leading to New Medications in Depression and Schizophrenia) consortium with prospective data on treatment outcome with either a serotonergic or noradrenergic antidepressant. No association was seen between the presence of CNV (rare or common), the overall number of CNVs or genomic CNV 'burden' and antidepressant response. Specific CNVs were nominally associated with antidepressant response, including 15q13.3 duplications and exonic NRXN1 deletions. These were associated with poor response to antidepressants. Overall burden of CNVs is unlikely to contribute to personalising antidepressant treatment. Specific CNVs associated with antidepressant treatment require replication and further study to confirm their role in the therapeutic action of antidepressant.
C1 [Tansey, K. E.; Rucker, J. J. H.; Aitchison, K. J.; Craig, I.; Farmer, A.; Kapur, S.; McGuffin, P.; Uher, R.] Kings Coll London, Inst Psychiat, London SE5 8AF, England.
   [Kavanagh, D. H.; O'Donovan, M.] Cardiff Univ, Sch Med, Dept Psychol Med & Neurol, MRC,Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales.
   [Guipponi, M.; Malafosse, A.] Univ Hosp Geneva, Dept Genet Med & Labs, Geneva, Switzerland.
   [Perroud, N.; Bondolfi, G.; Malafosse, A.] Univ Geneva, Dept Psychiat, Geneva, Switzerland.
   [Perroud, N.; Bondolfi, G.] Univ Hosp Geneva, Dept Mental Hlth & Psychiat, Geneva, Switzerland.
   [Domenici, E.] F Hoffmann La Roche & Co Ltd, Pharma Res & Early Dev, CH-4002 Basel, Switzerland.
   [Evans, D. M.] Univ Bristol, Sch Social & Community Med, MRC CAiTE Ctr, Bristol, Avon, England.
   [Hausers, J.] Poznan Univ Med Sci, Lab Psychiat Genet, Poznan, Poland.
   [Henigsberg, N.] Univ Zagreb, Sch Med, Croatian Inst Brain Res, Zagreb 41001, Croatia.
   [Jerman, B.] Jozef Stefan Inst, Dept Mol & Biomed Sci, Ljubljana, Slovenia.
   [Jerman, B.] Inst Publ Hlth Republ Slovenia, Ljubljana, Slovenia.
   [Maier, W.] Univ Bonn, Dept Psychiat, Bonn, Germany.
   [Mors, O.] Aarhus Univ Hosp, Res Dept P, Risskov, Denmark.
   [Peters, T. J.] Univ Bristol, Sch Clin Sci, Bristol, Avon, England.
   [Placentino, A.] Spedali Civili Hosp, Dept Mental Hlth, Psychiat Unit 23, Brescia, Italy.
   [Placentino, A.] Ctr San Giovanni di Dio Fatebenefratelli, Biol Psychiat Unit, Brescia, Italy.
   [Rietschel, M.] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.
   [Souery, D.] Univ Libre Brussels, Erasme Acad Hosp, Dept Psychiat, Brussels, Belgium.
   [Aitchison, K. J.] Univ Alberta, Dept Psychiat, Edmonton, AB, Canada.
   [Wendland, J. R.] Pfizer, Worldwide R&D, Cambridge, MA USA.
   [Lewis, G.] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
   [Uher, R.] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
RP Tansey, KE (reprint author), Kings Coll London, Inst Psychiat, P080,16 De Crespigny Pk, London SE5 8AF, England.
EM katherine.tansey@kcl.ac.uk
RI Tansey, Katherine/B-1033-2013; Aitchison, Katherine/G-4476-2013; Lewis,
   Glyn/E-9944-2012
OI Tansey, Katherine/0000-0002-9663-3376; Aitchison,
   Katherine/0000-0002-1107-3024; Lewis, Glyn/0000-0001-5205-8245
FU Wellcome Trust [086635]; Innovative Medicine Initiative Joint
   Undertaking (IMI-JU) [115008]; European Federation of Pharmaceutical
   Industries and Associations (EFPIA); European Union; European
   Commission, EC [LSHB-CT-2003-503428]; UK National Institute for Health
   Research of the Department of Health; UK Medical Research Council (MRC,
   UK); GlaxoSmithKline [G0701420]; Medical Research Council (MRC, UK);
   Mental Health Research Network; Canada Research Chair program;
   Wyeth-Lederle; Bristol-Myers-Squibb; Sanofi Aventis
FX The funders had no role in study design, data collection and analysis,
   decision to publish or preparation of the manuscript. The research
   leading to these results has received support from the Innovative
   Medicine Initiative Joint Undertaking (IMI-JU) under Grant agreement no.
   115008 of which resources are composed of European Union and the
   European Federation of Pharmaceutical Industries and Associations
   (EFPIA) in-kind contribution and financial contribution from the
   European Union's Seventh Framework Programme (FP7/2007-2013). EFPIA
   members Pfizer, Glaxo Smith Kline and F. Hoffmann La-Roche have
   contributed work and samples to the project presented here. GENDEP was
   funded by the European Commission Framework 6 grant, EC Contract Ref.:
   LSHB-CT-2003-503428. Lundbeck provided nortriptyline and escitalopram
   for the GENDEP study. GlaxoSmithKline and the UK National Institute for
   Health Research of the Department of Health contributed to the funding
   of the sample collection at the Institute of Psychiatry, London. GENDEP
   genotyping was funded by a joint grant from the UK Medical Research
   Council (MRC, UK) and GlaxoSmithKline (G0701420). GenPod was funded by
   the Medical Research Council (MRC, UK) and supported by the Mental
   Health Research Network. GODS study was partly supported by external
   funding provided by the Swiss branches of the following pharmaceutical
   companies: GlaxoSmithKline, Wyeth-Lederle, Bristol-Myers-Squibb and
   Sanofi Aventis. RU is supported by the Canada Research Chair program
   (http://www.chairs-chaires.gc.ca/). JR was supported by a fellowship
   from the Wellcome Trust (086635).
CR Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Colella S, 2007, NUCLEIC ACIDS RES, V35, P2013, DOI 10.1093/nar/gkm076
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Garriock HA, 2010, BIOL PSYCHIAT, V67, P133, DOI 10.1016/j.biopsych.2009.08.029
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Grozeva D, 2010, ARCH GEN PSYCHIAT, V67, P318, DOI 10.1001/archgenpsychiatry.2010.25
   Investigators G, 2013, AM J PSYCHIAT, V170, P207
   Ising M, 2009, ARCH GEN PSYCHIAT, V66, P966, DOI 10.1001/archgenpsychiatry.2009.95
   Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
   Kirov G, 2009, SCHIZOPHRENIA BULL, V35, P851, DOI 10.1093/schbul/sbp079
   Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
   Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Perroud N, 2011, PHARMACOGENOMICS, V12, P365, DOI [10.2217/pgs.10.189, 10.2217/PGS.10.189]
   Pinto D, 2011, NAT BIOTECHNOL, V29, P512, DOI 10.1038/nbt.1852
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
   Rucker JJH, 2013, MOL PSYCHIATR, V18, P183, DOI 10.1038/mp.2011.144
   Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   StataCorp, 2007, STAT STAT SOFTW REL
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   TANSEY KE, 2012, PLOS MED, V0009
   Tansey ME, 2013, BIOL PSYCHIAT, V73, P679
   Team RDC, 2011, R LANG ENV STAT COMP
   Thomas L, 2008, TRIALS, V9, DOI 10.1186/1745-6215-9-29
   Uher R, 2009, BRIT J PSYCHIAT, V194, P252, DOI 10.1192/bjp.bp.108.057554
   Uher R, 2012, PHARMACOGENOMICS, V13, P233, DOI [10.2217/pgs.11.161, 10.2217/PGS.11.161]
   Uher R, 2010, AM J PSYCHIAT, V167, P555, DOI 10.1176/appi.ajp.2009.09070932
   Vacic V, 2011, NATURE, V471, P499, DOI 10.1038/nature09884
   Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
   Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
NR 34
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1470-269X
EI 1473-1150
J9 PHARMACOGENOMICS J
JI Pharmacogenomics J.
PD AUG
PY 2014
VL 14
IS 4
BP 395
EP 399
DI 10.1038/tpj.2013.51
PG 5
WC Genetics & Heredity; Pharmacology & Pharmacy
SC Genetics & Heredity; Pharmacology & Pharmacy
GA AM9QL
UT WOS:000340216000014
PM 24445990
ER

PT J
AU Baecker, T
   Mangus, K
   Pfaender, S
   Chhabra, R
   Boeckers, TM
   Grabrucker, AM
AF Baecker, Tanja
   Mangus, Katharina
   Pfaender, Stefanie
   Chhabra, Resham
   Boeckers, Tobias M.
   Grabrucker, Andreas M.
TI Loss of COMMD1 and copper overload disrupt zinc homeostasis and
   influence an autism-associated pathway at glutamatergic synapses
SO BIOMETALS
LA English
DT Article
DE ProSAP; ASD; Shank3; Shank2; COMMD1; Zn2+; Synapse; PSD; Cu2+
ID COPY-NUMBER VARIATION; SPECTRUM DISORDERS; POSTSYNAPTIC DENSITY; MUTUAL
   ANTAGONISM; TRACE-ELEMENTS; DE-NOVO; SHANK3; METALLOTHIONEIN; MUTATIONS;
   GENE
AB Recent studies suggest that synaptic pathology in autism spectrum disorder (ASD) might be caused by the disruption of a signaling pathway at excitatory glutamatergic synapses, which can be influenced by environmental factors. Some factors, such as prenatal zinc deficiency, dysfunction of metallothioneins as well as deletion of COMMD1, all affect brain metal-ion homeostasis and have been associated with ASD. Given that COMMD1 regulates copper levels and that copper and zinc have antagonistic properties, here, we followed the idea that copper overload might induce a local zinc deficiency affecting key players of a putative ASD pathway such as ProSAP/Shank proteins as reported before. Our results show that increased copper levels indeed interfere with intracellular zinc concentrations and affect synaptic ProSAP/Shank levels, which similarly are altered by manipulation of copper and zinc levels through overexpression and knockdown of COMMD1. In line with this, acute and prenatal copper overload lead to local zinc deficiencies in mice. Pups exposed to prenatal copper overload furthermore show a reduction in ProSAP/Shank protein levels in the brain as well as a decreased NMDAR subunit 1 concentration. Thus, it might be likely that brain metal ion status influences a distinct pathway in excitatory synapses associated with genetic forms of ASD.
C1 [Baecker, Tanja; Mangus, Katharina; Chhabra, Resham; Grabrucker, Andreas M.] Univ Ulm, Dept Neurol, WG Mol Anal Synaptopathies, Neuroctr, D-89081 Ulm, Germany.
   [Pfaender, Stefanie; Boeckers, Tobias M.; Grabrucker, Andreas M.] Univ Ulm, Inst Anat & Cell Biol, D-89081 Ulm, Germany.
RP Grabrucker, AM (reprint author), Univ Ulm, Dept Neurol, WG Mol Anal Synaptopathies, Neuroctr, Albert Einstein Allee 11, D-89081 Ulm, Germany.
EM andreas.grabrucker@uni-ulm.de
FU Baustein 3.2 [L.SBN.0083]; DAAD
FX AMG is supported by Baustein 3.2 (L.SBN.0083) and the DAAD. SP and RC
   are members of the international graduate school in molecular medicine
   of Ulm University.
CR Arons MH, 2012, J NEUROSCI, V32, P14966, DOI 10.1523/JNEUROSCI.2215-12.2012
   Baron MK, 2006, SCIENCE, V311, P531, DOI 10.1126/science.1118995
   Barone A, 1998, J NUTR, V128, P1037
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Bjorklund G, 2013, ACTA NEUROBIOL EXP, V73, P225
   Bost M, 2012, J TRACE ELEM MED BIO, V26, P97, DOI 10.1016/j.jtemb.2012.04.024
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   COUSINS RJ, 1983, J INHERIT METAB DIS, V6, P15, DOI 10.1007/BF01811318
   COYLE P, 1994, BIOCHEM J, V303, P781
   Das SK, 2006, NAT CLIN PRACT NEURO, V2, P482
   De Bie P, 2005, J HERED, V96, P803, DOI 10.1093/jhered/esi110
   Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
   Denayer A, 2012, MOL SYNDROMOL, V3, P14, DOI DOI 10.1159/000339119
   Doreulee N, 1997, HIPPOCAMPUS, V7, P666, DOI 10.1002/(SICI)1098-1063(1997)7:6<666::AID-HIPO8>3.0.CO;2-C
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Faber S, 2009, BIOMARKERS, V14, P171, DOI 10.1080/13547500902783747
   Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
   Grabrucker A, 2009, CELL TISSUE RES, V338, P333, DOI 10.1007/s00441-009-0881-z
   Grabrucker Andreas M, 2012, Front Psychiatry, V3, P118, DOI 10.3389/fpsyt.2012.00118
   Grabrucker AM, 2011, EMBO J, V30, P569, DOI 10.1038/emboj.2010.336
   Grabrucker AM, 2011, DRUG DELIV LETT, V1, P13, DOI 10.2174/2210303111101010013
   Grabrucker AM, 2011, TRENDS CELL BIOL, V21, P594, DOI 10.1016/j.tcb.2011.07.003
   Grabrucker S, 2014, BRAIN, V137, P137, DOI 10.1093/brain/awt303
   Hagerman R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-12
   HALL AC, 1979, J INORG BIOCHEM, V11, P57, DOI 10.1016/S0162-0134(00)80054-9
   HILL CH, 1970, FED PROC, V29, P1474
   Huster D, 2010, BEST PRACT RES CL GA, V24, P531, DOI 10.1016/j.bpg.2010.07.014
   JAARSMA D, 1990, J NEUROSCI METH, V35, P125, DOI 10.1016/0165-0270(90)90102-L
   Jen M, 2010, CLIN DERMATOL, V28, P669, DOI 10.1016/j.clindermatol.2010.03.029
   Johnson S, 2001, MED HYPOTHESES, V56, P641, DOI 10.1054/mehy.2000.1302
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Manning MA, 2004, PEDIATRICS, V114, P451, DOI 10.1542/peds.114.2.451
   Meyer G, 2004, NEUROPHARMACOLOGY, V47, P724, DOI 10.1016/j.neuropharm.2004.06.023
   MILLS CF, 1985, ANNU REV NUTR, V5, P173
   Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
   Naisbitt S, 1999, NEURON, V23, P569, DOI 10.1016/S0896-6273(00)80809-0
   OESTREICHER P, 1985, J NUTR, V115, P159
   Pfaender S, 2014, METALLOMICS, V6, P960, DOI 10.1039/c4mt00008k
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Priya MDL, 2011, BIOL TRACE ELEM RES, V142, P148, DOI 10.1007/s12011-010-8766-2
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Russo A J, 2011, Nutr Metab Insights, V4, P19, DOI 10.4137/NMI.S6760
   Russo A J, 2011, Biomark Insights, V6, P127, DOI 10.4137/BMI.S7286
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Underwood EJ, 1977, TRACE ELEMENTS HUMAN, V4<SUP>th</SUP>
   Verpelli C, 2011, J BIOL CHEM, V286, P34839, DOI 10.1074/jbc.M111.258384
   Walker LR, 2011, J PREGNANCY, V2011
   Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yasuda H, 2011, SCI REP-UK, V1, DOI 10.1038/srep00129
   Yasuda H, 2013, SCI REP-UK, V3, DOI 10.1038/srep01199
NR 54
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0966-0844
EI 1572-8773
J9 BIOMETALS
JI Biometals
PD AUG
PY 2014
VL 27
IS 4
BP 715
EP 730
DI 10.1007/s10534-014-9764-1
PG 16
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AM5EJ
UT WOS:000339878700012
PM 25007851
ER

PT J
AU Harvey, L
   Boksa, P
AF Harvey, Louise
   Boksa, Patricia
TI Additive effects of maternal iron deficiency and prenatal immune
   activation on adult behaviors in rat offspring
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Prenatal infection; Maternal immune activation; Maternal iron
   deficiency; Behavior; Schizophrenia; Autism; Maternal diet
ID NEUROCHEMICAL PROFILE; VENTRAL HIPPOCAMPUS; BACTERIAL-ENDOTOXIN;
   BRAIN-DEVELOPMENT; SCHIZOPHRENIA; PREGNANCY; INFECTION; MICE; ALTERS;
   ANEMIA
AB Both iron deficiency (ID) and infection are common during pregnancy and studies have described altered brain development in offspring as a result of these individual maternal exposures. Given their high global incidence, these two insults may occur simultaneously during pregnancy. We recently described a rat model which pairs dietary ID during pregnancy and prenatal immune activation. Pregnant rats were placed on iron sufficient (IS) or ID diets from embryonic day 2 (E2) until postnatal day 7, and administered the bacterial endotoxin, lipopolysaccharide (LPS) or saline on E15/16. In this model, LPS administration on E15 caused greater induction of the pro-inflammatory cytokines, interleukin-6 and tumor necrosis factor-alpha, in ID dams compared to IS dams. This suggested that the combination of prenatal immune activation on a background of maternal ID might have more adverse neurodevelopmental consequences for the offspring than exposure to either insult alone. In this study we used this model to determine whether combined exposure to maternal ID and prenatal immune activation interact to affect juvenile and adult behaviors in the offspring. We assessed behaviors relevant to deficits in humans or animals that have been associated with exposure to either maternal ID or prenatal immune activation alone. Adult offspring from ID dams displayed significant deficits in pre-pulse inhibition of acoustic startle and in passive avoidance learning, together with increases in cytochrome oxidase immunohistochemistry, a marker of metabolic activity, in the ventral hippocampus immediately after passive avoidance testing. Offspring from LPS treated dams showed a significant increase in social behavior with unfamiliar rats, and subtle locomotor changes during exploration in an open field and in response to amphetamine. Surprisingly, there was no interaction between effects of the two insults on the behaviors assessed, and few observed alterations in juvenile behavior. Our findings show that long-term effects of maternal ID and prenatal LPS were additive, such that offspring exposed to both insults displayed more adult behavioral abnormalities than offspring exposed to one alone. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Harvey, Louise; Boksa, Patricia] McGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, Verdun, PQ H4H IR3, Canada.
RP Boksa, P (reprint author), McGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, 6875 Salle Blvd, Verdun, PQ H4H IR3, Canada.
EM patricia.boksa@mcgill.ca
FU Canadian Institutes of Health Research
FX We would like to thank Ying Zhang for technical assistance with the
   cytochrome oxidase histochemistry and Dominique Nouel for technical
   assistance with brain collection. This work was supported financially by
   the Canadian Institutes of Health Research.
CR Ashdown H, 2007, AM J PHYSIOL-REG I, V292, pR1667, DOI 10.1152/ajpregu.00274.2006
   Ashdown H, 2006, MOL PSYCHIATR, V11, P47, DOI 10.1038/sj.mp.4001748
   BABRI S, 2013, BRAIN BEHAV IMMUN, V37, P164
   Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
   Brown AS, 2006, SCHIZOPHRENIA BULL, V32, P200, DOI 10.1093/schbul/sbj052
   Brown AS, 2011, PROG NEUROBIOL, V93, P23, DOI 10.1016/j.pneurobio.2010.09.003
   Coe Christopher L, 2009, Dev Psychobiol, V51, P301, DOI 10.1002/dev.20365
   Connor JR, 1996, GLIA, V17, P83, DOI 10.1002/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7
   Cui K, 2009, SCHIZOPHR RES, V113, P288, DOI 10.1016/j.schres.2009.05.003
   Cui K, 2011, J ENDOCRINOL, V209, P95, DOI 10.1530/JOE-10-0436
   de Deungria M, 2000, Pediatr Res, V48, P169
   Deb Kaushik, 2004, Archives of Gynecology and Obstetrics, V270, P133, DOI 10.1007/s00404-004-0623-0
   Degroot A, 2002, BRAIN RES, V949, P60, DOI 10.1016/S0006-8993(02)02965-7
   Eseh R, 2005, BEHAV BRAIN RES, V164, P214, DOI 10.1016/j.bbr.2005.06.019
   Felt BT, 2006, BEHAV BRAIN RES, V171, P261, DOI 10.1016/j.bbr.2006.04.001
   File SE, 2003, EUR J PHARMACOL, V463, P35, DOI 10.1016/S0014-2999(03)01273-1
   Foley KA, 2014, INT J DEV NEUROSCI
   Fortier ME, 2004, J PSYCHIAT RES, V38, P335, DOI 10.1016/j.jpsychires.2003.10.001
   Fortier ME, 2007, BEHAV BRAIN RES, V181, P270, DOI 10.1016/j.bbr.2007.04.016
   Gambling L, 2003, J NUTR, V133, p1554S
   Georgieff MK, 2011, NUTR REV, V69, pS43, DOI 10.1111/j.1753-4887.2011.00432.x
   Giovanoli S, 2013, SCIENCE, V339, P1095, DOI 10.1126/science.1228261
   Haider BA, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f3443
   Hare D, 2013, FRONT AGING NEUROSCI, V5, DOI 10.3389/fnagi.2013.00034
   Harvey L, 2014, BRAIN BEHAV IMMUN, V35, P144, DOI 10.1016/j.bbi.2013.09.009
   Hava G, 2006, DEV PSYCHOBIOL, V48, P162, DOI 10.1002/dev.20116
   Insel BJ, 2008, ARCH GEN PSYCHIAT, V65, P1136, DOI 10.1001/archpsyc.65.10.1136
   Jougleux JL, 2011, J NUTR, V141, P1390, DOI 10.3945/jn.110.135715
   Kemna E, 2005, BLOOD, V106, P1864, DOI 10.1182/blood-2005-03-1159
   Khandaker GM, 2013, PSYCHOL MED, V43, P239, DOI 10.1017/S0033291712000736
   Kirsten TB, 2010, NEUROIMMUNOMODULAT, V17, P240, DOI 10.1159/000290040
   Koenig JI, 2005, BEHAV BRAIN RES, V156, P251, DOI 10.1016/j.bbr.2004.05.030
   Kwik-Uribe CL, 2000, J NUTR, V130, P2821
   Lin YL, 2012, BRAIN BEHAV IMMUN, V26, P459, DOI 10.1016/j.bbi.2011.12.003
   Lipina TV, 2013, J NEUROSCI, V33, P7654, DOI 10.1523/JNEUROSCI.0091-13.2013
   Lorenzini CGA, 1997, BRAIN RES, V768, P242
   Lozoff B, 2006, NUTR REV, V64, pS34, DOI 10.1301/nr.2006.may.S34-S43
   McBride SM, 2006, AM J PHYSIOL-REG I, V291, pR1192, DOI 10.1152/ajpregu.00774.2005
   McLean E, 2009, PUBLIC HEALTH NUTR, V12, P444, DOI 10.1017/S1368980008002401
   Meyer U, 2005, NEUROSCI BIOBEHAV R, V29, P913, DOI 10.1016/j.neubiorev.2004.10.012
   Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
   Miller JE, 2013, PAEDIATR PERINAT EP, V27, P542, DOI 10.1111/ppe.12082
   MOSER P, 2013, EUR NEUROPSYCHOPHARM, V24, P774
   Naef L, 2008, PSYCHOPHARMACOLOGY, V197, P83, DOI 10.1007/s00213-007-1008-4
   Pagani A, 2011, BLOOD, V118, P736, DOI 10.1182/blood-2011-02-337212
   Powell CM, 2006, BIOL PSYCHIAT, V59, P1198, DOI 10.1016/j.biopsych.2006.05.008
   Radlowski EC, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00585
   Rao R, 2011, NUTR NEUROSCI, V14, P59, DOI 10.1179/1476830511Y.0000000001
   Rao R, 2003, J NUTR, V133, P3215
   Rasmussen SA, 2012, AM J OBSTET GYNECOL, V207, pS3, DOI 10.1016/j.ajog.2012.06.068
   Romero E, 2010, MOL PSYCHIATR, V15, P372, DOI 10.1038/mp.2008.44
   Shi LM, 2003, J NEUROSCI, V23, P297
   Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
   SORENSEN HJ, 2010, SCHIZOPHR B, V37, P982
   Trivedi MA, 2004, NEUROBIOL LEARN MEM, V81, P172, DOI 10.1016/j.nlm.2004.02.005
   Velu Prasad Palani, 2011, J Glob Health, V1, P171
   Wolff AR, 2008, BEHAV BRAIN RES, V190, P156, DOI 10.1016/j.bbr.2008.02.021
   WONGRILEY MTT, 1989, TRENDS NEUROSCI, V12, P94, DOI 10.1016/0166-2236(89)90165-3
   Wu LL, 2008, BEHAV BRAIN RES, V188, P263, DOI 10.1016/j.bbr.2007.11.003
   YU GSM, 1986, AM J PATHOL, V125, P620
NR 60
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2014
VL 40
BP 27
EP 37
DI 10.1016/j.bbi.2014.06.005
PG 11
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA AL9JW
UT WOS:000339458400004
PM 24930842
ER

PT J
AU Giovanoli, S
   Weber, L
   Meyer, U
AF Giovanoli, Sandra
   Weber, Liz
   Meyer, Urs
TI Single and combined effects of prenatal immune activation and
   peripubertal stress on parvalbumin and reelin expression in the
   hippocampal formation
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Animal model; Autism; Cytokines; GABA; Infection; Inflammation; Stress;
   Schizophrenia
ID BIPOLAR DISORDER; ANIMAL-MODEL; SCHIZOPHRENIA; BRAIN; DYSREGULATION;
   INTERNEURONS; PREGNANCY; MICE; PATHOPHYSIOLOGY; INFLAMMATION
AB Exposure to prenatal infection and traumatizing experiences in peripubertal life are two environmental risk factors for developmental neuropsychiatric disorders. Modeling the cumulative neuronal impact of these factors in a translational animal model has led to the recent identification of pathological interactions between these environmental adversities in the development of adult brain dysfunctions. The present study explored the consequences of combined prenatal immune challenge and peripubertal stress on discrete cellular abnormalities in the gamma-aminobutyric acid (GABA) system of the hippocampus. Pregnant mice were treated with the viral mimetic poly(I:C) (=polyriboinosinic-polyribocytidilic add) or control solution, and offspring born to poly(I:C)-exposed or control mothers were then left undisturbed or subjected to unpredictable sub-chronic stress during peripubertal development. Stereological estimations of parvalbumin-expressing cells revealed a significant reduction of these GABAergic interneurons in the ventral dentate gyrus of adult offspring exposed to combined immune activation and stress. Single exposure to either environmental factor was insufficient to cause similar neuropathology. We further found that peripubertal stress exerted opposite effects on reelin-immunoreactive cells in the dorsal cornu ammonis (CA) region of the hippocampus, with stress increasing and decreasing reelin expression in control offspring and prenatally immune challenged animals, respectively. The present data suggest that the combination of two environmental risk factors, which have each been implicated in the etiology of major neuropsychiatric disease, induces significant but restricted neuropathological effects on hippocampal GABAergic cell populations known to be affected in brain disorders with neurodevelopmental components. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Giovanoli, Sandra; Weber, Liz; Meyer, Urs] Swiss Fed Inst Technol, Physiol & Behav Lab, CH-8603 Schwerzenbach, Switzerland.
RP Meyer, U (reprint author), Swiss Fed Inst Technol, Physiol & Behav Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland.
EM urmeyer@ethz.ch
FU European Union's (EU) Seventh Framework Programme (FP7) [259679]; Swiss
   National Science Foundation [310030_146217/1]
FX The present study was supported by The European Union's (EU) Seventh
   Framework Programme (FP7/2007-2011) under grant agreement No. 259679 and
   by the Swiss National Science Foundation (grant 310030_146217/1) awarded
   to U.M.
CR Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Bayer TA, 1999, J PSYCHIAT RES, V33, P543, DOI 10.1016/S0022-3956(99)00039-4
   Brown AS, 2011, PROG NEUROBIOL, V93, P23, DOI 10.1016/j.pneurobio.2010.09.003
   Brown AS, 2004, ARCH GEN PSYCHIAT, V61, P774, DOI 10.1001/archpsyc.61.8.774
   Cabungcal JH, 2013, BIOL PSYCHIAT, V73, P574, DOI 10.1016/j.biopsych.2012.09.020
   Fatemi SH, 2005, MOL PSYCHIATR, V10, P251, DOI 10.1038/sj.mp.4001613
   Fatemi SH, 1999, MOL PSYCHIATR, V4, P145, DOI 10.1038/sj.mp.4000520
   Fisher HL, 2010, PSYCHOL MED, V40, P1967, DOI 10.1017/S0033291710000231
   Folsom TD, 2013, NEUROPHARMACOLOGY, V68, P122, DOI 10.1016/j.neuropharm.2012.08.015
   Franklin K.B.J., 2008, MOUSE BRAIN STEREOTA, V3rd
   Giovanoli S, 2013, SCIENCE, V339, P1095, DOI 10.1126/science.1228261
   Gonzalez-Burgos G, 2012, SCHIZOPHRENIA BULL, V38, P950, DOI 10.1093/schbul/sbs010
   Grace AA, 2010, NEUROTOX RES, V18, P367, DOI 10.1007/s12640-010-9154-6
   Grace AA, 2012, NEUROPHARMACOLOGY, V62, P1342, DOI 10.1016/j.neuropharm.2011.05.011
   Gross CM, 2012, HIPPOCAMPUS, V22, P409, DOI 10.1002/hipo.20907
   Guidotti A, 2000, ARCH GEN PSYCHIAT, V57, P1061, DOI 10.1001/archpsyc.57.11.1061
   Gundersen H.J., 1988, APMIS, V96, P857
   Harvey L, 2012, NEUROPHARMACOLOGY, V62, P1767, DOI 10.1016/j.neuropharm.2011.11.022
   Herz J, 2006, NAT REV NEUROSCI, V7, P850, DOI 10.1038/nrn2009
   Howard CV, 2005, UNBIASED STEREOLOGY
   Lewis DA, 2006, ARCH NEUROL-CHICAGO, V63, P1372, DOI 10.1001/archneur.63.10.1372
   Lodge DJ, 2011, TRENDS PHARMACOL SCI, V32, P507, DOI 10.1016/j.tips.2011.05.001
   Lodge DJ, 2009, J NEUROSCI, V29, P2344, DOI 10.1523/JNEUROSCI.5419-08.2009
   Lu CB, 2011, NEUROBIOL LEARN MEM, V95, P221, DOI 10.1016/j.nlm.2010.11.008
   Maynard TM, 2001, SCHIZOPHRENIA BULL, V27, P457
   Meyer U, 2005, NEUROSCI BIOBEHAV R, V29, P913, DOI 10.1016/j.neubiorev.2004.10.012
   Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
   Meyer U, 2010, PROG NEUROBIOL, V90, P285, DOI 10.1016/j.pneurobio.2009.10.018
   Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
   Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
   Nouel D, 2012, EUR NEUROPSYCHOPHARM, V22, P300, DOI 10.1016/j.euroneuro.2011.08.001
   Parboosing R, 2013, JAMA PSYCHIAT, V70, P677, DOI 10.1001/jamapsychiatry.2013.896
   Piontkewitz Y, 2012, BRAIN BEHAV IMMUN, V26, P353, DOI 10.1016/j.bbi.2011.11.004
   Spear LP, 2000, NEUROSCI BIOBEHAV R, V24, P417, DOI 10.1016/S0149-7634(00)00014-2
   Steullet P, 2010, J NEUROSCI, V30, P2547, DOI 10.1523/JNEUROSCI.3857-09.2010
   Teixeira CM, 2011, NEUROPSYCHOPHARMACOL, V36, P2395, DOI 10.1038/npp.2011.153
   van Os J, 2010, NATURE, V468, P203, DOI 10.1038/nature09563
   Volk DW, 2013, NEUROSCIENCE, V248, P154, DOI 10.1016/j.neuroscience.2013.06.008
   Wang AY, 2011, ACTA NEUROPATHOL, V122, P615, DOI 10.1007/s00401-011-0881-4
NR 40
TC 4
Z9 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2014
VL 40
BP 48
EP 54
DI 10.1016/j.bbi.2014.04.005
PG 7
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA AL9JW
UT WOS:000339458400007
PM 24859043
ER

PT J
AU Fujiwara, T
   Kasahara, M
   Tsujii, H
   Okuyama, M
AF Fujiwara, Takeo
   Kasahara, Mari
   Tsujii, Hiromi
   Okuyama, Makiko
TI Association of maternal developmental disorder traits with child
   mistreatment: A prospective study in Japan
SO CHILD ABUSE & NEGLECT
LA English
DT Article
DE Autism Spectrum Disorder; Pervasive Developmental Disorder; Attention
   Deficit Hyperactivity Disorder; Child Abuse; Child maltreatment; Mental
   health
ID RISK-FACTORS; SUBSTANCE-ABUSE; MALTREATMENT; SAMPLE; NEGLECT;
   POPULATION; PREVALENCE; VIOLENCE; PARENTS; MOTHERS
AB Maternal mental disorders are known risk factors for child mistreatment. However, little is known about the involvement of maternal developmental disorder traits. The aim of this study was to examine maternal traits related to Pervasive Developmental Disorder (PDD) and Attention Deficit Hyperactivity Disorder (ADHD), and their possible association with child mistreatment. Maternal PDD and ADHD were assessed through a self-administered questionnaire (N = 846) during mid-pregnancy using the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) and Adult ADHD Self-Report Scale (ASRS). The mothers completed another questionnaire on child mistreatment when the offspring was approximately 18 months of age. The associations between maternal PDD and ADHD traits and child mistreatment score were analyzed using linear regression models adjusted for covariates. Mothers who exhibited stronger PDD traits showed significantly higher child mistreatment score, even after adjustment for maternal characteristics at baseline and ADHD traits. At the same time, ADHD traits were significantly associated with child mistreatment after adjustment of covariates, although the association became non-significant after adjustment of PDD traits. Mothers who showed PDD and ADHD traits during pregnancy were more likely to mistreat their children. It is essential to educate mothers with such traits with appropriate, easy-to-follow childcare instructions, preferably in simple language combined with pictorial aids. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Fujiwara, Takeo] Natl Res Inst Child Hlth & Dev, Dept Social Med, Setagaya Ku, Tokyo, Japan.
   [Kasahara, Mari] Komagino Hosp, Dept Psychiat, Hachioji, Tokyo, Japan.
   [Tsujii, Hiromi; Okuyama, Makiko] Natl Ctr Child Hlth & Dev, Dept Psychosocial Med, Setagaya Ku, Tokyo, Japan.
RP Fujiwara, T (reprint author), Natl Res Inst Child Hlth & Dev, Dept Social Med, Setagaya Ku, Tokyo, Japan.
CR ADACHI J, 2008, SEISHIN IGAKU, V50, P431
   Brown J, 1998, CHILD ABUSE NEGLECT, V22, P1065, DOI 10.1016/S0145-2134(98)00087-8
   CAPPELLERI JC, 1993, AM J PUBLIC HEALTH, V83, P1622, DOI 10.2105/AJPH.83.11.1622
   Chaffin M, 1996, CHILD ABUSE NEGLECT, V20, P191, DOI 10.1016/S0145-2134(95)00144-1
   DINWIDDIE SH, 1993, CHILD ABUSE NEGLECT, V17, P465, DOI 10.1016/0145-2134(93)90021-V
   Fox S., 1985, BRIT J SOC WORK, V15, P451
   Fujiwara T, 2012, CHILD CARE HLTH DEV, V38, P530, DOI 10.1111/j.1365-2214.2011.01272.x
   Ito H, 2012, RES AUTISM SPECT DIS, V6, P1265, DOI 10.1016/j.rasd.2012.04.002
   Kamio Y., 2006, SEISHIN IGAKU, V48, P495
   KELLEHER K, 1994, AM J PUBLIC HEALTH, V84, P1586, DOI 10.2105/AJPH.84.10.1586
   Kessler RC, 2005, PSYCHOL MED, V35, P245, DOI 10.1017/S0033291704002892
   Sizoo B, 2010, DRUG ALCOHOL DEPEN, V107, P44, DOI 10.1016/j.drugalcdep.2009.09.003
   Kotch JB, 1999, CHILD ABUSE NEGLECT, V23, P305, DOI 10.1016/S0145-2134(99)00003-4
   Lundstrom S, 2011, PSYCHOL MED, V41, P2423, DOI 10.1017/S0033291711000377
   May T, 2013, J AUTISM DEV DISORD, V43, P2147, DOI 10.1007/s10803-013-1766-2
   McConnell D, 2011, CHILD ABUSE NEGLECT, V35, P621, DOI 10.1016/j.chiabu.2011.04.005
   Ministry of Health. Labor and Welfare in Japan, 2012, NAT C DIR CHILD PROT
   Murphy A, 2014, CHILD ABUSE NEGLECT, V38, P224, DOI 10.1016/j.chiabu.2013.09.004
   MURPHY JM, 1991, CHILD ABUSE NEGLECT, V15, P197, DOI 10.1016/0145-2134(91)90065-L
   Rose GA, 1992, STRATEGY PREVENTIVE
   Rumm PD, 2000, CHILD ABUSE NEGLECT, V24, P1375, DOI 10.1016/S0145-2134(00)00192-7
   Runyan DK, 2009, CHILD ABUSE NEGLECT, V33, P826, DOI 10.1016/j.chiabu.2009.09.006
   Senoo E., 2000, KOSEI SHIHYO, V47, P3
   Sidebotham P, 2002, CHILD ABUSE NEGLECT, V26, P1243, DOI 10.1016/S0145-2134(02)00415-5
   Sidebotham P, 2001, CHILD ABUSE NEGLECT, V25, P1177, DOI 10.1016/S0145-2134(01)00261-7
   Simonoff E, 2013, J CHILD PSYCHOL PSYC, V54, P186, DOI 10.1111/j.1469-7610.2012.02606.x
   STIER DM, 1993, PEDIATRICS, V91, P642
   Straus MA, 1998, CHILD ABUSE NEGLECT, V22, P249, DOI 10.1016/S0145-2134(97)00174-9
   Tajima EA, 2000, CHILD ABUSE NEGLECT, V24, P1383, DOI 10.1016/S0145-2134(00)00194-0
   Watanabe Y., 2000, JAPANESE B SOCIAL PS, V10, P239
   Windham AM, 2004, CHILD ABUSE NEGLECT, V28, P645, DOI 10.1016/j.chiabu.2004.01.003
   Wu SS, 2004, CHILD ABUSE NEGLECT, V28, P1253, DOI 10.1016/j.chiabu.2004.07.005
NR 32
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0145-2134
EI 1873-7757
J9 CHILD ABUSE NEGLECT
JI Child Abuse Negl.
PD AUG
PY 2014
VL 38
IS 8
BP 1283
EP 1289
DI 10.1016/j.chiabu.2014.04.007
PG 7
WC Family Studies; Psychology, Social; Social Work
SC Family Studies; Psychology; Social Work
GA AM4YV
UT WOS:000339863000001
PM 24813254
ER

PT J
AU Yau, VM
   Green, PG
   Alaimo, CP
   Yoshida, CK
   LUtsky, M
   Windham, GC
   Delorenze, G
   Kharrazi, M
   Grether, JK
   Croen, LA
AF Yau, Vincent M.
   Green, Peter G.
   Alaimo, Christopher P.
   Yoshida, Cathleen K.
   LUtsky, Marta
   Windham, Gayle C.
   Delorenze, Gerald
   Kharrazi, Martin
   Grether, Judith K.
   Croen, Lisa A.
TI Prenatal and neonatal peripheral blood mercury levels and autism
   spectrum disorders
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Autism; Mercury; Pregnancy; Developmental delay; Intellectual disability
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; THIMEROSAL-CONTAINING
   VACCINES; HAZARDOUS AIR-POLLUTANTS; CENTRAL-NERVOUS-SYSTEM; FISH
   CONSUMPTION; DEVELOPMENTAL DISORDERS; ENVIRONMENTAL-FACTORS; URINARY
   PORPHYRINS; INORGANIC MERCURY; CHILD-DEVELOPMENT
AB Background: Prenatal and early-life exposures to mercury have been hypothesized to be associated with increased risk of autism spectrum disorders (ASDs).
   Objectives: This study investigated the association between ASDs and levels of total mercury measured in maternal serum from mid-pregnancy and infant blood shortly after birth.
   Methods: The study sample was drawn from the Early Markers for Autism (EMA) Study. Three groups of children who were born in Orange County, CA in 2000-2001 were identified: children with ASD (n=84), children with intellectual disability or developmental delay (DD) (n=49), and general population controls (GP) (n=159). Maternal serum specimens and newborn bloodspots were retrieved from the California Department of Public Health prenatal and newborn screening specimen archives. Blood mercury levels were measured in maternal serum samples using mass spectrometer and in infant bloodspots with a 213 nm laser.
   Results: Maternal serum and infant blood mercury levels were significantly correlated among all study groups (all correlations > 0.38, p < 0.01). Adjusted logistic regression models showed no significant associations between ASD and log transformed mercury levels in maternal serum samples (ASD vs. GP: OR [95% CI]=0.96 [0.49-1.90]; ASD vs. DD: OR [95% CI]=2.56 [0.89-7.39]). Results for mercury levels in newborn blood samples were similar (ASD vs. GP: OR [95% CI]=1.18 [0.71-1.95]; ASD vs. DD: OR [95% CI]=1.96 [0.75-5.14]).
   Conclusions: Results indicate that levels of total mercury in serum collected from mothers during mid-pregnancy and from newborn bloodspots were not significantly associated with risk of ASD, though additional studies with greater sample size and covariate measurement are needed. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yau, Vincent M.; Yoshida, Cathleen K.; LUtsky, Marta; Delorenze, Gerald; Croen, Lisa A.] Kaiser Permanente, Div Res, Oakland, CA USA.
   [Green, Peter G.; Alaimo, Christopher P.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA.
   [Windham, Gayle C.; Grether, Judith K.] Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Richmond, CA USA.
   [Kharrazi, Martin] Calif Dept Publ Hlth, Genet Dis Screening Program, Richmond, CA USA.
RP Croen, LA (reprint author), Kaiser Permanente, Div Res, Autism Res Program, 2000 Broadway Oakland, Oakland, CA 94612 USA.
EM Lisa.A.Croen@kp.org
FU National Institute of Mental Health [R01-MH72565]; National Alliance for
   Autism Research [824/LC/01-201-004-00-00]; California Tobacco-Related
   Disease Research Program [8RT-0115]
FX Funding was provided by grants from the National Institute of Mental
   Health (R01-MH72565, L. Croen, PI), the National Alliance for Autism
   Research (824/LC/01-201-004-00-00, L. Croen, PI), and the California
   Tobacco-Related Disease Research Program (8RT-0115, M. Kharrazi, PI). We
   thank Ron Torres for DNA amplification; Jack Collins, Roxana Odouli and
   Tiffany Wong for project coordination; Julie Ruedaflores for record
   review and abstraction; Meredith Anderson and Daniel Najjar for
   assistance with data management and analysis; and Steve Graham and
   Debbie Hildebrandt for record linkage and specimen retrieval.
CR Abdullah M.M., 2011, J AUTISM DEV DISORD
   Adams JB, 2007, J TOXICOL ENV HEAL A, V70, P1046, DOI 10.1080/15287390601172080
   Albizzati A, 2012, MINERVA PEDIATR, V64, P27
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Andrews N, 2004, PEDIATRICS, V114, P584, DOI 10.1542/peds.2003-1177-L
   Ask K, 2002, ENVIRON HEALTH PERSP, V110, P523
   ATSDR, 1999, ATSDR TOX PROF MERC
   Baker JP, 2008, AM J PUBLIC HEALTH, V98, P244, DOI 10.2105/AJPH.2007.113159
   Bauman M. L., 2005, NEUROBIOLOGY AUTISM
   Berglund Marika, 2005, Environ Health, V4, P20, DOI 10.1186/1476-069X-4-20
   Beversdorf DQ, 2005, J AUTISM DEV DISORD, V35, P471, DOI 10.1007/s10803-005-5037-8
   Bjornberg KA, 2005, ENVIRON HEALTH PERSP, V113, P1381, DOI 10.1289/ehp.7856
   Blanchard K. Stephen, 2011, Reviews on Environmental Health, V26, P111, DOI 10.1515/REVEH.2011.015
   Boucher O, 2012, ENVIRON HEALTH PERSP, V120, P1456, DOI 10.1289/ehp.1204976
   BRYANT HE, 1989, AM J PUBLIC HEALTH, V79, P78, DOI 10.2105/AJPH.79.1.78
   Bunin GR, 2001, AM J EPIDEMIOL, V154, P1136, DOI 10.1093/aje/154.12.1136
   Burbacher TM, 2005, ENVIRON HEALTH PERSP, V113, P1015, DOI 10.1289/ehp.7712
   Chaudhuri SN, 2009, J EXPO SCI ENV EPID, V19, P298, DOI [10.1038/jesee.2008.19, 10.1038/jes.2008.19]
   COX C, 1989, ENVIRON RES, V49, P318, DOI 10.1016/S0013-9351(89)80075-1
   Croen LA, 2008, AM J OBSTET GYNECOL, V199, P234
   Croen LA, 2008, AUTISM RES, V1, P130, DOI 10.1002/aur.14
   Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006
   Daniels JL, 2004, EPIDEMIOLOGY, V15, P394, DOI 10.1097/01.ede.0000129514.46451.ce
   Davidson PW, 1998, JAMA-J AM MED ASSOC, V280, P701, DOI 10.1001/jama.280.8.701
   DeLong G, 2011, J TOXICOL ENV HEAL A, V74, P903, DOI 10.1080/15287394.2011.573736
   De Palma G, 2012, J AUTISM DEV DISORD, V42, P342, DOI 10.1007/s10803-011-1245-6
   Desoto M Catherine, 2007, J Child Neurol, V22, P1308, DOI 10.1177/0883073807307111
   EPA, 2010, HUM EXP I MERC I US
   Fido A, 2005, AUTISM, V9, P290, DOI 10.1177/1362361305053255
   Fombonne E, 2006, PEDIATRICS, V118, pE139, DOI 10.1542/peds.2005-2993
   Gallagher CM, 2010, J TOXICOL ENV HEAL A, V73, P1665, DOI 10.1080/15287394.2010.519317
   Geier DA, 2009, J TOXICOL ENV HEAL A, V72, P1585, DOI 10.1080/15287390903232475
   Geier DA, 2009, ACTA NEUROBIOL EXP, V69, P189
   Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
   Goldman LR, 2001, PEDIATRICS, V108, P197, DOI 10.1542/peds.108.1.197
   Grandjean P, 2006, LANCET, V368, P2167, DOI 10.1016/S0140-6736(06)69665-7
   Grandjean R., 1997, NEUROTOXICOL TERATOL, V19, P417
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hansen J., 1981, SURVEY HUMAN EXPOSUR
   Hensley E, 2010, J AM PHARM ASSOC, V50, P736, DOI 10.1331/JAPhA.2010.10004
   Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
   Hertz-Picciotto I, 2010, ENVIRON HEALTH PERSP, V118, P161, DOI 10.1289/ehp.0900736
   Hightower JM, 2006, ENVIRON HEALTH PERSP, V114, P173, DOI 10.1289/ehp.8464
   HILL AB, 1965, P ROY SOC MED, V58, P295
   Hsieh HF, 2009, TALANTA, V79, P183, DOI 10.1016/j.talanta.2009.03.027
   Hurley Anne M, 2010, J Pediatr Pharmacol Ther, V15, P173
   Hviid A, 2003, JAMA-J AM MED ASSOC, V290, P1763, DOI 10.1001/jama.290.13.1763
   Institute of Medicine, 2004, IMM SAF REV VACC AUT
   Ip P, 2004, J CHILD NEUROL, V19, P431
   Jedrychowski W, 2006, ANN EPIDEMIOL, V16, P439, DOI 10.1016/j.annepidem.2005.06.059
   Julvez J., 2013, FRONT GENET, V4
   Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76
   Kern JK, 2011, PEDIATR INT, V53, P147, DOI 10.1111/j.1442-200X.2010.03196.x
   Kern JK, 2007, J TOXICOL ENV HEAL A, V70, P715, DOI 10.1080/15287390601188060
   Lederman SA, 2008, ENVIRON HEALTH PERSP, V116, P1085, DOI 10.1289/ehp.10831
   Lewandowski TA, 2009, J TOXICOL ENV HEAL A, V72, P1592, DOI 10.1080/15287390903232483
   Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
   Lynch ML, 2011, ENVIRON RES, V111, P75, DOI 10.1016/j.envres.2010.09.005
   Madsen KM, 2003, PEDIATRICS, V112, P604, DOI 10.1542/peds.112.3.604
   Majewska MD, 2010, ACTA NEUROBIOL EXP, V70, P196
   Mania Monika, 2012, Rocz Panstw Zakl Hig, V63, P257
   MARSH DO, 1980, ANN NEUROL, V7, P348, DOI 10.1002/ana.410070412
   MATSUMOT.H, 1965, J NEUROPATH EXP NEUR, V24, P563, DOI 10.1097/00005072-196510000-00002
   McCann P., 2011, FIN REP GLNPO ID 200
   Miller L, 2009, J SPEC PEDIATR NURS, V14, P166, DOI 10.1111/j.1744-6155.2009.00194.x
   Miranda ML, 2011, INT J ENV RES PUB HE, V8, P698, DOI 10.3390/ijerph8030698
   MMWR, 2004, MMWR-MORBID MORTAL W, V53, P1018
   Mrozek-Budzyn Dorota, 2011, Przegl Epidemiol, V65, P491
   Nyland JF, 2011, ENVIRON RES, V111, P584, DOI 10.1016/j.envres.2011.02.010
   Oken E, 2008, AM J EPIDEMIOL, V167, P1171, DOI 10.1093/aje/kwn034
   Oken E, 2005, ENVIRON HEALTH PERSP, V113, P1376, DOI 10.1289/ehp.8041
   Philbert MA, 2000, TOXICOL PATHOL, V28, P43, DOI 10.1177/019262330002800107
   Pichichero ME, 2008, PEDIATRICS, V121, pE208, DOI 10.1542/peds.2006-3363
   Price CS, 2010, PEDIATRICS, V126, P656, DOI 10.1542/peds.2010-0309
   Priya MDL, 2011, BIOL TRACE ELEM RES, V142, P148, DOI 10.1007/s12011-010-8766-2
   Rahbar M.H., 2012, NEUROTOX RES
   RAPHAEL K, 1987, INT J EPIDEMIOL, V16, P167, DOI 10.1093/ije/16.2.167
   Rodier PM, 2004, PEDIATRICS, V113, P1076
   Rodrigues JL, 2010, ARCH TOXICOL, V84, P891, DOI 10.1007/s00204-010-0538-4
   Rothman K, 1998, MODERN EPIDEMIOLOGY, V2nd
   Sagiv SK, 2012, ARCH PEDIAT ADOL MED, V166, P1123, DOI 10.1001/archpediatrics.2012.1286
   Sakamoto M, 2010, ECOTOX ENVIRON SAFE, V73, P1, DOI 10.1016/j.ecoenv.2009.09.010
   Santos E.Q., 2007, SAUDE PALICAMINISTER, V23, pS622
   Savabieasfahani M., 2011, B ENV CONTAM TOXICOL
   Schechter R, 2008, ARCH GEN PSYCHIAT, V65, P19, DOI 10.1001/archgenpsychiatry.2007.1
   Schultz ST, 2010, ACTA NEUROBIOL EXP, V70, P187
   Sigma-Aldrich, 2012, MAT SAF DAT SHEET ME
   Sigma-Aldrich, 2012, MAT SAF DAT SHEET TH
   Stamova B, 2011, NEUROTOX RES, V19, P31, DOI 10.1007/s12640-009-9137-7
   Szatmari P, 1998, J AUTISM DEV DISORD, V28, P351, DOI 10.1023/A:1026096203946
   Takeuchi T, 1982, Acta Pathol Jpn, V32 Suppl 1, P73
   TRUSKA P, 1989, Journal of Hygiene Epidemiology Microbiology and Immunology (Prague), V33, P141
   van Wijngaarden E, 2013, EPIDEMIOLOGY, V24, P651, DOI 10.1097/EDE.0b013e31829d2651
   Verstraeten T, 2003, PEDIATRICS, V112, P1039
   Wilcox AJ, 2011, AM J EPIDEMIOL, V174, P1062, DOI 10.1093/aje/kwr230
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Wright B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029547
   Yang JM, 1997, ANN CLIN LAB SCI, V27, P135
   Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
   Young HA, 2008, J NEUROL SCI, V271, P110, DOI 10.1016/j.jns.2008.04.002
NR 100
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD AUG
PY 2014
VL 133
BP 294
EP 303
DI 10.1016/j.envres.2014.04.034
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AM2UI
UT WOS:000339705900038
PM 24981828
ER

PT J
AU Suckling, J
   Henty, J
   Ecker, C
   Deoni, SC
   Lombardo, MV
   Baron-Cohen, S
   Jezzard, P
   Barnes, A
   Chakrabarti, B
   Ooi, C
   Lai, MC
   Williams, SC
   Murphy, DGM
   Bullmore, ET
AF Suckling, John
   Henty, Julian
   Ecker, Christine
   Deoni, Sean C.
   Lombardo, Michael V.
   Baron-Cohen, Simon
   Jezzard, Peter
   Barnes, Anna
   Chakrabarti, Bhismadev
   Ooi, Cinly
   Lai, Meng-Chuan
   Williams, Steven C.
   Murphy, Declan G. M.
   Bullmore, Edward T.
CA MRC AIMS Consortium
TI Are Power Calculations Useful? A Multicentre Neuroimaging Study
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE power calculations; neuroimaging; multicentre
ID STATISTICAL POWER; FUNCTIONAL MRI; BRAIN; AUTISM; REGISTRATION;
   VARIANCE; REPRODUCIBILITY; BEHAVIOR; ANATOMY; IMAGES
AB There are now many reports of imaging experiments with small cohorts of typical participants that precede large-scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration experiments are sufficient to make estimates of statistical power and predictions of sample size and minimum observable effect sizes. In this technical note, we suggest how previously reported voxel-based power calculations can support decision making in the design, execution and analysis of cross-sectional multicentre imaging studies. The choice of MRI acquisition sequence, distribution of recruitment across acquisition centres, and changes to the registration method applied during data analysis are considered as examples. The consequences of modification are explored in quantitative terms by assessing the impact on sample size for a fixed effect size and detectable effect size for a fixed sample size. The calibration experiment dataset used for illustration was a precursor to the now complete Medical Research Council Autism Imaging Multicentre Study (MRC-AIMS). Validation of the voxel-based power calculations is made by comparing the predicted values from the calibration experiment with those observed in MRC-AIMS. The effect of non-linear mappings during image registration to a standard stereotactic space on the prediction is explored with reference to the amount of local deformation. In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources. (C) 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
C1 [Suckling, John; Henty, Julian; Ooi, Cinly; Bullmore, Edward T.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge, England.
   [Suckling, John; Ooi, Cinly; Bullmore, Edward T.] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England.
   [Suckling, John; Baron-Cohen, Simon; Bullmore, Edward T.] Cambridge & Peterborough Fdn NHS Trust, Cambridge, England.
   [Ecker, Christine; Murphy, Declan G. M.] Kings Coll London, Sackler Inst Translat Neurodev, London WC2R 2LS, England.
   [Ecker, Christine; Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London WC2R 2LS, England.
   [Deoni, Sean C.] Brown Univ, Div Engn, Providence, RI 02912 USA.
   [Lombardo, Michael V.; Baron-Cohen, Simon; Chakrabarti, Bhismadev; Lai, Meng-Chuan] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Jezzard, Peter] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England.
   [Barnes, Anna] Univ Coll London Hosp, Inst Nucl Med, London, England.
   [Chakrabarti, Bhismadev] Univ Reading, Sch Psychol & Clin Language Sci, Ctr Integrat Neurosci & Neurodynam, Reading, Berks, England.
   [Williams, Steven C.] Kings Coll London, Inst Psychiat, Ctr Neuroimaging Sci, London, England.
   [Bullmore, Edward T.] Addenbrookes Hosp, GlaxoSmithKline Ltd, Clin Unit Cambridge, Cambridge, England.
RP Suckling, J (reprint author), Dept Psychiat, Brain Mapping Unit, Herchel Smith Bldg,Robinson Way, Cambridge CB2 0SZ, England.
EM js369@cam.ac.uk
RI Williams, Steve/D-6979-2011; Ecker, Christine/E-5194-2010
FU Medical Research Council, United Kingdom [G0400061]; Behavioural and
   Clinical Neurosciences Institute, Wellcome Trust; Cambridge Biomedical
   Research Centre, National Institute of Health Research
FX Contract grant sponsor: Medical Research Council, United Kingdom;
   Contract grant number: G0400061; Contract grant sponsors: Behavioural
   and Clinical Neurosciences Institute, Wellcome Trust; Cambridge
   Biomedical Research Centre, National Institute of Health Research
CR Brown CH, 2009, ANNU REV PUBL HEALTH, V30, P1, DOI 10.1146/annurev.publhealth.031308.100223
   Brown GG, 2011, NEUROIMAGE, V54, P2163, DOI 10.1016/j.neuroimage.2010.09.076
   Costafreda SG, 2007, J MAGN RESON IMAGING, V26, P1122, DOI 10.1002/jmri.21118
   Deoni SCL, 2008, NEUROIMAGE, V40, P662, DOI 10.1016/j.neuroimage.2007.11.052
   Deoni SCL, 2007, J MAGN RESON IMAGING, V26, P1106, DOI 10.1002/jmri.21130
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Ecker C, 2013, JAMA PSYCHIAT, V70, P59, DOI 10.1001/jamapsychiatry.2013.265
   Gountouna VE, 2010, NEUROIMAGE, V49, P552, DOI 10.1016/j.neuroimage.2009.07.026
   Hoenig JM, 2002, J SPEECH LANG HEAR R, V45, P493
   Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
   Klein A, 2009, NEUROIMAGE, V46, P786, DOI 10.1016/j.neuroimage.2008.12.037
   Lenth RV, 2001, AM STAT, V55, P187, DOI 10.1198/000313001317098149
   Lenth RV, 2007, J ANIM SCI, V85, pE24, DOI 10.2527/jas.2006-449
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Magnotta VA, 2006, J DIGIT IMAGING, V19, P140, DOI 10.1007/s10278-006-0264-x
   Miller F, 2005, BIOMETRICS, V61, P355, DOI 10.1111/j.1541-0420.2005.00315.x
   Pinheiro J. C., 2000, MIXED EFFECTS MODELS
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Shokouhi M, 2011, BMC MED IMAGING, V11, DOI 10.1186/1471-2342-11-23
   Sled JG, 1998, IEEE T MED IMAGING, V17, P87, DOI 10.1109/42.668698
   Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062
   Suckling J, 2012, HUM BRAIN MAPP, V33, P373, DOI 10.1002/hbm.21210
   Suckling J, 2010, HUM BRAIN MAPP, V31, P1183, DOI 10.1002/hbm.20927
   Suckling J, 2008, HUM BRAIN MAPP, V29, P1111, DOI 10.1002/hbm.20451
   Suckling J, 2006, NEUROIMAGE, V31, P197, DOI 10.1016/j.neuroimage.2005.11.032
   Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
   Zhang YY, 2001, IEEE T MED IMAGING, V20, P45, DOI 10.1109/42.906424
   Zou KH, 2005, RADIOLOGY, V237, P781, DOI 10.1148/radiol.2373041630
NR 28
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD AUG
PY 2014
VL 35
IS 8
BP 3569
EP 3577
DI 10.1002/hbm.22465
PG 9
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AL8YV
UT WOS:000339426700001
PM 24644267
ER

PT J
AU Verly, M
   Verhoeven, J
   Zink, I
   Mantini, D
   Van Oudenhove, L
   Lagae, L
   Sunaert, S
   Rommel, N
AF Verly, Marjolein
   Verhoeven, Judith
   Zink, Inge
   Mantini, Dante
   Van Oudenhove, Lukas
   Lagae, Lieven
   Sunaert, Stefan
   Rommel, Nathalie
TI Structural and Functional Underconnectivity as a Negative Predictor for
   Language in Autism
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE autism spectrum disorder; diffusion tensor imaging; language impairment;
   arcuate fascicle; functional MRI
ID CEREBRAL WHITE-MATTER; HUMAN BRAIN; ARCUATE FASCICULUS; SPECTRUM
   DISORDER; FRONTAL-CORTEX; SENTENCE COMPREHENSION; CONNECTIVITY MRI;
   HEALTHY-SUBJECTS; CROSSING FIBERS; IN-VIVO
AB The development of language, social interaction, and communicative skills are remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported in this patient population. However, the interplay between their brain connectivity and language performance remains largely understudied. Using diffusion tensor imaging tractography and resting-state fMRI, the authors explored the structural and functional connectivity of the language network and its relation to the language profile in a group of healthy control subjects (N = 25) and a group of children with ASD (N = 17). The authors hypothesized that in children with ASD, a neural connectivity deficit of the language network can be related to the observed abnormal language function. They found an absence of the right-hemispheric arcuate fascicle (AF) in 28% (7/25) of the healthy control children and in 59% (10/17) of the children with ASD. In contrast to healthy control children, the absence of the right-hemispheric AF in children with autism was related to a lower language performance as indicated by a lower verbal IQ, lower scores on the Pea-body Picture Vocabulary Test, and lower language scores on the Dutch version of the Clinical Evaluation of Language Fundamentals (CELF-4NL). In addition, through iterative fMRI data analyses, the language impairment of children with ASD could be linked to a marked loss of intrahemispheric functional connectivity between inferior frontal and superior temporal regions, known as the cortical language network. Both structural and functional underconnectivity patterns coincide and are related to an abnormal language function in children with ASD. (C) 2013 Wiley Periodicals, Inc.
C1 [Verly, Marjolein; Zink, Inge; Rommel, Nathalie] Katholieke Univ Leuven, ExpORL, Dept Neurosci, B-3000 Leuven, Belgium.
   [Verhoeven, Judith; Lagae, Lieven] Katholieke Univ Leuven, Univ Hosp, Dept Pediat, Leuven, Belgium.
   [Mantini, Dante] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England.
   [Mantini, Dante] ETH, Dept Hlth Sci & Technol, Zurich, Switzerland.
   [Mantini, Dante] Katholieke Univ Leuven, Dept Neurosci, Lab Neurophysiol & Psychophysiol, B-3000 Leuven, Belgium.
   [Van Oudenhove, Lukas] Katholieke Univ Leuven, Dept Clin & Expt Med, Translat Res Ctr Gastrointestinal Disorders TARGI, B-3000 Leuven, Belgium.
   [Van Oudenhove, Lukas] Katholieke Univ Leuven, Univ Psychiat Ctr, B-3000 Leuven, Belgium.
   [Sunaert, Stefan] Katholieke Univ Leuven, Univ Hosp, Dept Radiol, Leuven, Belgium.
RP Verly, M (reprint author), Katholieke Univ Leuven, ExpORL, Dept Neurosci, Herestr 49, B-3000 Leuven, Belgium.
EM marjolein.verly@med.kuleuven.be
RI Rommel, Nathalie/D-6721-2014
FU Fund for Scientific Research-Flanders, FWO, Belgium [G.0354.06];
   Research Council of the University of Leuven [IDO/08/013]; IUAP-KUL
FX Contract grant sponsor: Fund for Scientific Research-Flanders, FWO,
   Belgium; Contract grant number: G.0354.06; Contract grant sponsor:
   Research Council of the University of Leuven; Contract grant number:
   IDO/08/013; Contract grant sponsor: IUAP-KUL.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   BASSER PJ, 1994, BIOPHYS J, V66, P259
   Beaulieu C, 2002, NMR BIOMED, V15, P435, DOI 10.1002/nbm.782
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Benson RR, 1999, NEUROLOGY, V52, P798
   BISWAL B, 1995, MAGNET RESON MED, V34, P537, DOI 10.1002/mrm.1910340409
   Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016
   Carper RA, 2000, BRAIN, V123, P836, DOI 10.1093/brain/123.4.836
   Catani M, 2005, ANN NEUROL, V57, P8, DOI 10.1002/ana.20319
   Catani M, 2007, P NATL ACAD SCI USA, V104, P17163, DOI 10.1073/pnas.0702116104
   Catani M, 2008, CORTEX, V44, P953, DOI 10.1016/j.cortex.2008.04.002
   Catani M, 2002, NEUROIMAGE, V17, P77, DOI 10.1006/nimg.2002.1136
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   Church JA, 2009, BRAIN, V132, P225, DOI 10.1093/brain/awn223
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Correia S, 2008, NEUROIMAGE, V42, P568, DOI 10.1016/j.neuroimage.2008.05.022
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
   Courchesne E, 2005, DEV PSYCHOPATHOL, V17, P577, DOI 10.1017/S0954579405050285
   Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020
   Damoiseaux JS, 2006, P NATL ACAD SCI USA, V103, P13848, DOI 10.1073/pnas.0601417103
   Deco G, 2011, NEUROSCIENTIST, V17, P107, DOI 10.1177/1073858409354384
   Dubois J, 2009, CEREB CORTEX, V19, P414, DOI 10.1093/cercor/bhn097
   Dunn L.M., 2005, PEABODY PICTURE VOCA
   Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
   Eluvathingal TJ, 2007, CEREB CORTEX, V17, P2760, DOI 10.1093/cercor/bhm003
   FINE J, 1994, J AUTISM DEV DISORD, V24, P315, DOI 10.1007/BF02172230
   Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083
   Friederici AD, 2006, CEREB CORTEX, V16, P1709, DOI 10.1093/cercor/bhj106
   Friston KJ, 1999, NEUROIMAGE, V10, P385, DOI 10.1006/nimg.1999.0484
   Glasser MF, 2008, CEREB CORTEX, V18, P2471, DOI 10.1093/cercor/bhn011
   Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
   Groen WB, 2008, NEUROSCI BIOBEHAV R, V32, P1416, DOI 10.1016/j.neubiorev.2008.05.008
   Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015
   Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
   Herbert MR, 2005, BRAIN, V128, P213, DOI 10.1093/brain/awh330
   Hohnen B, 1999, DEV PSYCHOL, V35, P590, DOI 10.1037/0012-1649.35.2.590
   Jeurissen B, 2011, HUM BRAIN MAPP, V32, P461, DOI 10.1002/hbm.21032
   Jones TB, 2010, NEUROIMAGE, V49, P401, DOI 10.1016/j.neuroimage.2009.07.051
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
   Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
   Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
   Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
   Knaus TA, 2010, BRAIN LANG, V112, P113, DOI 10.1016/j.bandl.2009.11.005
   Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216
   Kort W, 2008, CELF 4 NL CLIN EVALU
   Kort W., 2005, HANDLEIDING VERANTWO
   Lebel C, 2009, HUM BRAIN MAPP, V30, P3563, DOI 10.1002/hbm.20779
   Leemans A, 2009, 17 ANN M P INT SOC M
   Leemans A, 2009, MAGN RESON MED, V61, P13
   Makris N, 2005, CEREB CORTEX, V15, P854, DOI 10.1093/cercor/bhh186
   Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
   Nagae LM, 2012, AM J NEURORADIOL, V33, P1720, DOI 10.3174/ajnr.A3037
   Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Parker GJM, 2005, NEUROIMAGE, V24, P656, DOI 10.1016/j.neuroimage.2004.08.047
   PETERSEN SE, 1988, NATURE, V331, P585, DOI 10.1038/331585a0
   Powell HWR, 2006, NEUROIMAGE, V32, P388, DOI 10.1016/j.neuroimage.2006.03.011
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Rutter M., 2003, SOCIAL COMMUNICATION
   Shih P, 2010, NEUROPSYCHOLOGIA, V48, P2931, DOI 10.1016/j.neuropsychologia.2010.05.035
   Tournier JD, 2008, NEUROIMAGE, V42, P617, DOI 10.1016/j.neuroimage.2008.05.002
   Turner Katherine C, 2006, Behav Brain Funct, V2, P34, DOI 10.1186/1744-9081-2-34
   Verhoeven JS, 2012, CEREB CORTEX, V22, P2263, DOI 10.1093/cercor/bhr292
   Verhoeven JS, 2010, NEURORADIOLOGY, V52, P3, DOI 10.1007/s00234-009-0583-y
   Vernooij MW, 2007, NEUROIMAGE, V35, P1064, DOI 10.1016/j.neuroimage.2006.12.041
   Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
   Vos SB, 2011, NEUROIMAGE, V55, P1566, DOI 10.1016/j.neuroimage.2011.01.048
   Wakana S, 2007, NEUROIMAGE, V36, P630, DOI 10.1016/j.neuroimage.2007.02.049
   Wan CY, 2012, ANN NY ACAD SCI, V1252, P332, DOI 10.1111/j.1749-6632.2012.06446.x
   Wedeen VJ, 2008, NEUROIMAGE, V41, P1267, DOI 10.1016/j.neuroimage.2008.03.036
   Weissenbacher A, 2009, NEUROIMAGE, V47, P1408, DOI 10.1016/j.neuroimage.2009.05.005
   Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
   Wicker B, 2008, SOC COGN AFFECT NEUR, V3, P135, DOI 10.1093/scan/nsn007
   Williams D, 2008, PSYCHOL BULL, V134, P944, DOI [10.1037/a0013743, 10.1037/0013743]
NR 78
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD AUG
PY 2014
VL 35
IS 8
BP 3602
EP 3615
DI 10.1002/hbm.22424
PG 14
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AL8YV
UT WOS:000339426700004
PM 24375710
ER

PT J
AU Nair, A
   Keown, CL
   Datko, M
   Shih, P
   Keehn, B
   Muller, RA
AF Nair, Aarti
   Keown, Christopher L.
   Datko, Michael
   Shih, Patricia
   Keehn, Brandon
   Mueller, Ralph-Axel
TI Impact of Methodological Variables on Functional Connectivity Findings
   in Autism Spectrum Disorders
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE functional connectivity; fMRI; autism; resting state; region of
   interest; temporal filtering; task regression
ID HUMAN CEREBRAL-CORTEX; RESTING HUMAN BRAIN; CORTICAL UNDERCONNECTIVITY;
   SENTENCE COMPREHENSION; RESPONSE-INHIBITION; COGNITIVE CONTROL;
   VISUAL-CORTEX; GLOBAL SIGNAL; MOTOR TASK; STATE
AB Growing evidence suggests that Autism Spectrum Disorder (ASD) involves abnormalities of multiple functional networks. Neuroimaging studies of ASD have therefore increasingly focused on connectivity. Many functional connectivity (fcMRI) studies have reported network underconnectivity in children and adults with ASD. However, there are notable inconsistencies, with some studies reporting overconnectivity. A previous literature survey suggested that a few methodological factors play a crucial role in differential fcMRI outcomes. Using three ASD data sets (two task-related, one resting state) from 54 ASD and 51 typically developing (TD) participants (ages 9-18 years), we examined the impact of four methodological factors: type of pipeline (co-activation vs. intrinsic analysis, related to temporal filtering and removal of task-related effects), seed selection, field of view (whole brain vs. limited ROIs), and dataset. Significant effects were found for type of pipeline, field of view, and dataset. Notably, for each dataset results ranging from robust underconnectivity to robust overconnectivity were detected, depending on the type of pipeline, with intrinsic fcMRI analyses (low bandpass filter and task regressor) predominantly yielding overconnectivity in ASD, but co-activation analyses (no low bandpass filter or task removal) mostly generating underconnectivity findings. These results suggest that methodological variables have dramatic impact on group differences reported in fcMRI studies. Improved awareness of their implications appears indispensible in fcMRI studies when inferences about "underconnectivity" or "overconnectivity" in ASD are made. In the absence of a gold standard for functional connectivity, the combination of different methodological approaches promises a more comprehensive understanding of connectivity in ASD. (c) 2014 Wiley Periodicals, Inc.
C1 [Nair, Aarti; Keown, Christopher L.; Datko, Michael; Shih, Patricia; Keehn, Brandon; Mueller, Ralph-Axel] San Diego State Univ, Dept Psychol, Brain Dev Imaging Lab, San Diego, CA 92120 USA.
   [Nair, Aarti; Mueller, Ralph-Axel] San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92120 USA.
   [Nair, Aarti; Mueller, Ralph-Axel] Univ Calif San Diego, San Diego, CA 92103 USA.
   [Keown, Christopher L.; Datko, Michael] Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92103 USA.
   [Shih, Patricia] Brown Univ, Dept Neurosci, Providence, RI 02912 USA.
   [Keehn, Brandon] Harvard Univ, Sch Med, Boston Childrens Hosp, Labs Cognit Neurosci, Boston, MA USA.
RP Muller, RA (reprint author), San Diego State Univ, Dept Psychol, 6363 Alvarado Ct,Suite 200, San Diego, CA 92120 USA.
EM rmueller@mail.sdsu.edu
FU National Institutes of Health [R01-MH081023]; Autism Speaks Dennis
   Weatherstone Predoctoral Fellowship [7850]
FX Contract grant sponsor: National Institutes of Health; Contract grant
   number: R01-MH081023; Contract grant sponsor: Autism Speaks Dennis
   Weatherstone Predoctoral Fellowship; Contract grant numbers: 7850 (to
   A.N.).
CR Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
   Allen G, 2001, FRONT BIOSCI-LANDMRK, V6, pD105, DOI 10.2741/allen
   Beckmann CF, 2010, FRONT SYST NEUROSCI, V4, P1
   BISWAL B, 1995, MAGNET RESON MED, V34, P537, DOI 10.1002/mrm.1910340409
   Canolty RT, 2010, TRENDS COGN SCI, V14, P506, DOI 10.1016/j.tics.2010.09.001
   Canolty Ryan T, 2007, Front Neurosci, V1, P185, DOI 10.3389/neuro.01.1.1.014.2007
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Cordes D, 2000, AM J NEURORADIOL, V21, P1636
   Cordes D, 2001, AM J NEURORADIOL, V22, P1326
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Cox RW, 1996, COMPUT BIOMED RES, V29, P162, DOI 10.1006/cbmr.1996.0014
   Damarla SR, 2010, AUTISM RES, V3, P273, DOI 10.1002/aur.153
   Desikan RS, 2006, NEUROIMAGE, V31, P968, DOI 10.1016/j.neuroimage.2006.01.021
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Dosenbach NUF, 2007, P NATL ACAD SCI USA, V104, P11073, DOI 10.1073/pnas.0704320104
   DSM-IV-TR, 2000, DIAGN STAT MAN MENT
   Eapen V, 2011, CURR OPIN PSYCHIATR, V24, P226, DOI 10.1097/YCO.0b013e328345927e
   Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
   Fair DA, 2007, NEUROIMAGE, V35, P396, DOI 10.1016/j.neuroimage.2006.11.051
   Fischl B, 2004, CEREB CORTEX, V14, P11, DOI 10.1093/cercor/bhg087
   Fox MD, 2006, P NATL ACAD SCI USA, V103, P10046, DOI 10.1073/pnas.0604187103
   Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
   Fox MD, 2009, J NEUROPHYSIOL, V101, P3270, DOI 10.1152/jn.90777.2008
   Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
   Gotts SJ, 2013, FRONT HUM NEUROSCI, V7, P1
   Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
   Hampson M, 2002, HUM BRAIN MAPP, V15, P247, DOI 10.1002/hbm.10022
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Horwitz B, 2003, NEUROIMAGE, V19, P466, DOI 10.1016/S1053-8119(03)00112-5
   HORWITZ B, 1988, ARCH NEUROL-CHICAGO, V45, P749
   Hughes JR, 2007, EPILEPSY BEHAV, V11, P20, DOI 10.1016/j.yebeh.2007.03.010
   Jiang TZ, 2004, HUM BRAIN MAPP, V22, P63, DOI 10.1002/hbm.20012
   Johnson MH, 2011, DEV COGN NEUROS-NETH, V1, P7, DOI 10.1016/j.dcn.2010.07.003
   Jones TB, 2010, NEUROIMAGE, V49, P401, DOI 10.1016/j.neuroimage.2009.07.051
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510
   Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
   Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
   Keehn B, 2013, HUM BRAIN MAPP, V34, P2524, DOI 10.1002/hbm.22084
   Keehn B, 2013, NEUROSCI BIOBEHAV R, V37, P164, DOI 10.1016/j.neubiorev.2012.11.014
   Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
   Khan S, 2013, P NATL ACAD SCI USA, V110, P3107, DOI 10.1073/pnas.1214533110
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Koyama MS, 2011, J NEUROSCI, V31, P8617, DOI 10.1523/JNEUROSCI.4865-10.2011
   Kuhn T., 1962, STRUCTURE SCI REVOLU
   Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
   Leopold DA, 2003, CEREB CORTEX, V13, P422, DOI 10.1093/cercor/13.4.422
   Lewisa CM, 2009, P NATL ACAD SCI USA, V106, P17558, DOI 10.1073/pnas.0902455106
   Logothetis NK, 2004, MAGN RESON IMAGING, V22, P1517, DOI 10.1016/j.mri.2004.10.018
   Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   Lowe MJ, 1998, NEUROIMAGE, V7, P119, DOI 10.1006/nimg.1997.0315
   Lowe MJ, 2000, NEUROIMAGE, V12, P582, DOI 10.1006/nimg.2000.0654
   Lynch CJ, 2013, BIOL PSYCHIAT, V74, P212, DOI 10.1016/j.biopsych.2012.12.013
   Mason MF, 2007, SCIENCE, V315, P393, DOI 10.1126/science.1131295
   Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
   Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Muller RA, 2007, MENT RETARD DEV D R, V13, P85, DOI 10.1002/mrdd.20141
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Murphy K, 2009, NEUROIMAGE, V44, P893, DOI 10.1016/j.neuroimage.2008.09.036
   Nir Y, 2006, NEUROIMAGE, V30, P1313, DOI 10.1016/j.neuroimage.2005.11.018
   Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
   Rudie JD, 2013, NEUROIMAGE-CLIN, V2, P79, DOI 10.1016/j.nicl.2012.11.006
   Rudie JD, 2012, CEREB CORTEX, V22, P1025, DOI 10.1093/cercor/bhr171
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Saad Ziad S, 2012, Brain Connect, V2, P25, DOI 10.1089/brain.2012.0080
   Schipul SE, 2011, FRONTIERS SYSTEMS NE, V5, P1, DOI DOI 10.3389/FNSYS.2011.00010
   Scholvinck ML, 2010, P NATL ACAD SCI USA, V107, P10238, DOI 10.1073/pnas.0913110107
   Schultz DH, 2012, FRONT HUM NEUROSCI, V6, P1
   Seeley WW, 2007, J NEUROSCI, V27, P2349, DOI 10.1523/JNEUROSCI.5587-06.2007
   Serences JT, 2005, PSYCHOL SCI, V16, P114, DOI 10.1111/j.0956-7976.2005.00791.x
   Shen MD, 2012, NEUROIMAGE, V62, P1780, DOI 10.1016/j.neuroimage.2012.06.008
   Shih P, 2011, BIOL PSYCHIAT, V70, P270, DOI 10.1016/j.biopsych.2011.03.040
   Shih P, 2010, NEUROPSYCHOLOGIA, V48, P2931, DOI 10.1016/j.neuropsychologia.2010.05.035
   Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   Turner Katherine C, 2006, Behav Brain Funct, V2, P34, DOI 10.1186/1744-9081-2-34
   Van Dijk KRA, 2010, J NEUROPHYSIOL, V103, P297, DOI 10.1152/jn.00783.2009
   Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
   Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
   Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
   Wang ZJ, 2012, NEUROIMAGE, V62, P394, DOI 10.1016/j.neuroimage.2012.04.051
   Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005
   Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042
   Welchew DE, 2005, BIOL PSYCHIAT, V57, P991, DOI 10.1016/j.biopsych.2005.01.028
   Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
NR 96
TC 7
Z9 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD AUG
PY 2014
VL 35
IS 8
BP 4035
EP 4048
DI 10.1002/hbm.22456
PG 14
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AL8YV
UT WOS:000339426700035
PM 24452854
ER

PT J
AU Ben-David, E
   Shohat, S
   Shifman, S
AF Ben-David, Eyal
   Shohat, Shahar
   Shifman, Sagiv
TI Allelic expression analysis in the brain suggests a role for
   heterogeneous insults affecting epigenetic processes in autism spectrum
   disorders
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID X-CHROMOSOME INACTIVATION; DE-NOVO MUTATIONS; MONOALLELIC EXPRESSION;
   IMPRINTED GENES; RETT-SYNDROME; MOUSE-BRAIN; PATTERNS; UBE3A;
   NEUROBIOLOGY; CONNECTIVITY
AB Monoallelic expression, including genomic imprinting, X-chromosome inactivation and random monoallelic expression of autosomal genes are epigenetic phenomena. Genes that are expressed in a monoallelic way may be more vulnerable to genetic or epigenetic mutations. Thus, comprehensive exploration of monoallelic expression in human brains may shed light on complex brain disorders. Autism-related disorders are known to be associated with imprinted genes on chromosome 15. However, it is not clear whether other imprinted regions or other types of monoallelic expression are associated with autism spectrum disorder (ASD). Here, we performed a genome-wide survey of allele expression imbalance (AEI) in the human brain using single-nucleotide polymorphisms (SNPs), in 18 individuals with ASD and 15 controls. Individuals with ASD had the most extreme number of monoallelic expressed SNPs in both the autosomes and the X chromosome. In two cases that were studied in detail, the monoallelic expression was confined to specific brain region or cell type. Using these data, we were also able to define the allelic expression status of known imprinted genes in the human brain and to identify abnormal imprinting in an individual with ASD. Lastly, we developed an analysis of individual-level expression, focusing on the difference of each individual from the mean. We found that individuals with ASD had more genes that were up- or down-regulated in an individual-specific manner. We also identified pathways perturbed in specific individuals. These results underline the heterogeneity in gene regulation in ASD, at the level of both allelic and total expression.
C1 [Ben-David, Eyal; Shohat, Shahar; Shifman, Sagiv] Hebrew Univ Jerusalem, Dept Genet, Inst Life Sci, IL-91904 Jerusalem, Israel.
RP Shifman, S (reprint author), Hebrew Univ Jerusalem, Dept Genet, Inst Life Sci, Edmond J Safra campus, IL-91904 Jerusalem, Israel.
EM sagiv@vms.huji.ac.il
FU National Institute for Psychobiology in Israel; Legacy Heritage Fund
   program of the Israel Science Foundation [1998/08]; Israel Science
   Foundation [688/12]; Dennis Weatherstone Pre-doctoral Fellowship from
   Autism Speaks [8595]
FX This research was supported by grants from the National Institute for
   Psychobiology in Israel, the Legacy Heritage Fund program of the Israel
   Science Foundation (grant no. 1998/08), and Israel Science Foundation
   (grant no. 688/12). E. B. D. is supported by the Dennis Weatherstone
   Pre-doctoral Fellowship from Autism Speaks (grant no. 8595).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Amir RE, 1999, NAT GENET, V23, P185
   Badcock C, 2006, J EVOLUTION BIOL, V19, P1007, DOI 10.1111/j.1420-9101.2006.01091.x
   Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
   Ben-David E, 2013, MOL PSYCHIATR, V18, P1054, DOI 10.1038/mp.2012.148
   Ben-David E, 2011, HUM MOL GENET, V20, P3632, DOI 10.1093/hmg/ddr283
   Blaschke RJ, 2006, CURR OPIN GENET DEV, V16, P233, DOI 10.1016/j.gde.2006.04.004
   Browning BL, 2009, AM J HUM GENET, V84, P210, DOI 10.1016/j.ajhg.2009.01.005
   Buonocore F, 2010, HUM MOL GENET, V19, P4490, DOI 10.1093/hmg/ddq380
   Cahoy JD, 2008, J NEUROSCI, V28, P264, DOI 10.1523/JNEUROSCI.4178-07.2008
   Chamberlain SJ, 2010, J NEUROSCI, V30, P9958, DOI 10.1523/JNEUROSCI.1728-10.2010
   CHESS A, 1994, CELL, V78, P823, DOI 10.1016/S0092-8674(94)90562-2
   Chess A, 2005, NAT GENET, V37, P120, DOI 10.1038/ng0205-120
   Choi JD, 2005, MOL CELL BIOL, V25, P5514, DOI 10.1128/MCB.25.13.5514-5522.2005
   Cook EH, 1997, AM J HUM GENET, V60, P928
   Daelemans C, 2010, BMC GENET, V11, DOI 10.1186/1471-2156-11-25
   David M, 2011, BIOINFORMATICS, V27, P1011, DOI 10.1093/bioinformatics/btr046
   DeVeale B, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002600
   Du P, 2008, BIOINFORMATICS, V24, P1547, DOI 10.1093/bioinformatics/btn224
   Ecker C, 2013, P NATL ACAD SCI USA, V110, P13222, DOI 10.1073/pnas.1221880110
   Esumi S, 2005, NAT GENET, V37, P171, DOI 10.1038/ng1500
   Fradin D., 2010, PLOS ONE, V5, P8
   Franco B, 2006, CURR OPIN GENET DEV, V16, P254, DOI 10.1016/j.gde.2006.04.012
   Ge B, 2009, NAT GENET, V41, P1216, DOI 10.1038/ng.473
   Ge B, 2005, GENOME RES, V15, P1584, DOI 10.1101/gr.4023805
   Gimelbrant A, 2007, SCIENCE, V318, P1136, DOI 10.1126/science.1148910
   Gong XH, 2008, AM J MED GENET B, V147B, P830, DOI 10.1002/ajmg.b.30688
   Grafodatskaya D., 2013, BMC MED
   Gregg C, 2010, SCIENCE, V329, P643, DOI 10.1126/science.1190830
   Gregg C, 2010, SCIENCE, V329, P682, DOI 10.1126/science.1190831
   Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jeffries AR, 2012, STEM CELLS, V30, P1938, DOI 10.1002/stem.1155
   LaSalle JM, 2013, J HUM GENET, V58, P396, DOI 10.1038/jhg.2013.49
   Meng LY, 2012, HUM MOL GENET, V21, P3001, DOI 10.1093/hmg/dds130
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Monk D, 2011, NUCLEIC ACIDS RES, V39, P4577, DOI 10.1093/nar/gkq1230
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Ovadia G., 2011, PLOS ONE, V6, P7
   Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
   Plenge RM, 2002, AM J HUM GENET, V71, P168, DOI 10.1086/341123
   Pollard KS, 2008, HUM GENET, V122, P625, DOI 10.1007/s00439-007-0440-1
   Rada C, 2002, CURR BIOL, V12, pR108, DOI 10.1016/S0960-9822(02)00674-7
   Runte M, 2001, HUM MOL GENET, V10, P2687, DOI 10.1093/hmg/10.23.2687
   Samaco RC, 2005, HUM MOL GENET, V14, P483, DOI 10.1093/hmg/ddi045
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Schanen NC, 2006, HUM MOL GENET, V15, pR138, DOI 10.1093/hmg/ddl213
   Skuse DH, 2000, PEDIATR RES, V47, P9, DOI 10.1203/00006450-200001000-00006
   Talebizadeh Z, 2005, J AUTISM DEV DISORD, V35, P675, DOI 10.1007/s10803-005-0011-z
   Tycko B, 2002, J CELL PHYSIOL, V192, P245, DOI 10.1002/jcp.10129
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3_1
   Wintle RF, 2011, AUTISM RES, V4, P89, DOI 10.1002/aur.173
   Yin TF, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-8-r77
   Zambon AC, 2012, BIOINFORMATICS, V28, P2209, DOI 10.1093/bioinformatics/bts366
   ZOGHBI HY, 1990, BRAIN DEV-JPN, V12, P131
   Zwemer LM, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-2-r10
NR 60
TC 2
Z9 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD AUG 1
PY 2014
VL 23
IS 15
BP 4111
EP 4124
DI 10.1093/hmg/ddu128
PG 14
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AM2GV
UT WOS:000339669200018
PM 24659497
ER

PT J
AU Benson, PR
AF Benson, Paul R.
TI Coping and Psychological Adjustment Among Mothers of Children with ASD:
   An Accelerated Longitudinal Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Coping; Stress; Psychological adjustment; Autism spectrum disorders;
   ASD; Mothers
ID AUTISM SPECTRUM DISORDERS; MULTILEVEL MODELING APPROACH; PARENTAL
   SELF-EFFICACY; BEHAVIOR RATING FORM; DOUBLE ABCX MODEL;
   MENTAL-RETARDATION; SOCIAL SUPPORT; DEVELOPMENTAL-DISABILITIES;
   INTELLECTUAL DISABILITIES; STRESS PROLIFERATION
AB Utilizing a cohort sequential design and multilevel modeling on a sample of 113 mothers, the effects of four coping strategies (engagement, disengagement, distraction, and cognitive reframing) on multiple measures of maternal adjustment were assessed over a 7 years period when children with autism spectrum disorders in the study were approximately 7-14 years old. Findings indicated increased use of disengagement and distraction to be related to increased maternal maladjustment over time, while increased use of cognitive reframing was linked to improved maternal outcomes (findings regarding engagement's effects on adjustment measures were mixed). In addition, results indicated that use of different coping strategies at times moderated the effects of child behavior on maternal adjustment. Study findings are discussed in light of prior research and study limitations and clinical implications are highlighted.
C1 Univ Massachusetts, Dept Sociol, Boston, MA 02125 USA.
RP Benson, PR (reprint author), Univ Massachusetts, Dept Sociol, 100 Morrissey Blvd, Boston, MA 02125 USA.
EM paul.benson@umb.edu
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
   Aldwin C., 2011, OXFORD HDB STRESS HL, P5
   ALDWIN CM, 1987, J PERS SOC PSYCHOL, V53, P337, DOI 10.1037/0022-3514.53.2.337
   Algina J., 2011, HDB ADV MULTILEVEL A, P285
   Altiere MJ, 2009, J CHILD FAM STUD, V18, P83, DOI 10.1007/s10826-008-9209-y
   Aman MG, 1996, RES DEV DISABIL, V17, P41, DOI 10.1016/0891-4222(95)00039-9
   Baker BL, 2002, AM J MENT RETARD, V107, P433, DOI 10.1352/0895-8017(2002)107<0433:BPAPSI>2.0.CO;2
   Beck A, 2004, J INTELLECT DEV DIS, V29, P339, DOI 10.1080/13668250400014509
   Benson P, 2008, AUTISM, V12, P47, DOI 10.1177/1362361307085269
   Benson PR, 2010, RES AUTISM SPECT DIS, V4, P217, DOI 10.1016/j.rasd.2009.09.008
   Benson PR, 2012, J AUTISM DEV DISORD, V42, P2597, DOI 10.1007/s10803-012-1517-9
   Benson PR, 2013, RES AUTISM SPECT DIS, V7, P1129, DOI 10.1016/j.rasd.2013.06.003
   Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
   Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
   Benson PR, 2008, RES AUTISM SPECT DIS, V2, P583, DOI 10.1016/j.rasd.2007.12.002
   Bird CE, 1997, J MARRIAGE FAM, V59, P809, DOI 10.2307/353784
   Blackledge JT, 2006, CHILD FAM BEHAV THER, V28, P1, DOI 10.1300/J019v28n01_01
   CARVER CS, 1989, J PERS SOC PSYCHOL, V56, P267, DOI 10.1037//0022-3514.56.2.267
   Carver CS, 1997, INT J BEHAV MED, V4, P92, DOI 10.1207/s15327558ijbm0401_6
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   Deater-Deckard K. D., 2004, PARENTING STRESS
   Ekas N, 2010, AJIDD-AM J INTELLECT, V115, P234, DOI 10.1352/1944-7558-115.3.234
   Ekas N. V., 2009, J AUTISM DEV DISORD, V39, P707
   Essex EL, 1999, AM J MENT RETARD, V104, P545, DOI 10.1352/0895-8017(1999)104<0545:DICEAW>2.0.CO;2
   Fitzgerald M, 2002, IRISH J PSYCHOL, V23, P2
   FOLKMAN S, 1986, J PERS SOC PSYCHOL, V50, P571, DOI 10.1037//0022-3514.50.3.571
   FOLKMAN S, 1984, J PERS SOC PSYCHOL, V46, P839, DOI 10.1037/0022-3514.46.4.839
   Folkman S, 2004, ANNU REV PSYCHOL, V55, P745, DOI 10.1146/annurev.psych.55.090902.141456
   Gavidia-Payne S, 2002, J INTELLECT DEV DIS, V27, P31
   Gilmore L, 2012, J FAM STUD, V18, P28
   Gray DE, 2002, J INTELLECT DEV DIS, V27, P215, DOI 10.1080/1366825021000008639
   Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2
   Hastings RP, 2005, AUTISM, V9, P377, DOI 10.1177/1362361305056078
   Hastings RP, 2004, J CHILD PSYCHOL PSYC, V45, P1338, DOI 10.1111/j.1469-7610.2004.00357.x
   Hauser-Cram P, 2001, MONOGR SOC RES CHILD, V66, P1, DOI 10.1111/1540-5834.00151
   Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
   Hox J., 2010, MULTILEVEL ANAL TECH
   Jones L, 2013, J AUTISM DEV DISORD, V43, P2090, DOI 10.1007/s10803-012-1756-9
   Jones TL, 2005, CLIN PSYCHOL REV, V25, P341, DOI 10.1016/j.cpr.2004.12.004
   Kim HW, 2003, J INTELL DISABIL RES, V47, P313, DOI 10.1046/j.1365-2788.2003.00493.x
   KOREN PE, 1992, REHABIL PSYCHOL, V37, P305, DOI 10.1037/0090-5550.37.4.305
   Kuhn JC, 2006, AM J ORTHOPSYCHIAT, V76, P564, DOI 10.1037/0002-9432.76.4.564
   Lazarus R. S., 1984, STRESS APPRAISAL COP
   Lazarus R. S., 1996, HDB EMOTION ADULT DE, P289, DOI 10.1016/B978-012464995-8/50017-0
   Lecavalier L, 2004, J AUTISM DEV DISORD, V34, P709, DOI 10.1007/s10803-004-5291-1
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lloyd T, 2008, J INTELL DISABIL RES, V52, P37, DOI 10.1111/j.1365-2788.2007.00974.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lounds J, 2007, AM J MENT RETARD, V112, P401, DOI 10.1352/0895-8017(2007)112[401:TACIAA]2.0.CO;2
   Lyons AM, 2010, J CHILD FAM STUD, V19, P516, DOI 10.1007/s10826-009-9323-5
   Magana S, 2006, AM J ORTHOPSYCHIAT, V76, P346, DOI 10.1037/0002-9432.76.3.346
   Mirowsky J., 2003, SOCIAL CAUSES PSYCHO, V2nd
   Mitchell MN, 2012, INTERPRETING VISUALI
   Miyazaki Y, 2000, PSYCHOL METHODS, V5, P44, DOI 10.1037//1082-989X.5.1.44
   ORR RR, 1991, AM J MENT RETARD, V95, P444
   Pakenham K., 2011, OXFORD HDB STRESS HL, P242
   Pakenham KI, 2005, AUTISM, V9, P191, DOI 10.1177/1362361305049033
   Park C., 2011, OXFORD HDB STRESS HL, P227
   Pearlin L. I., 2000, HDB SOCIOLOGY MENTAL, P395
   Pottie CG, 2008, J FAM PSYCHOL, V22, P855, DOI 10.1037/a0013604
   PRUCHNO R, 1993, PSYCHOL AGING, V8, P18, DOI 10.1037//0882-7974.8.1.18
   Rabe-Hesketh S, 2008, MULTILEVEL LONGITUDI
   RAUDENBUSH SW, 1993, J CONSULT CLIN PSYCH, V61, P941, DOI 10.1037/0022-006X.61.6.941
   SELTZER MM, 1995, PSYCHOL AGING, V10, P64, DOI 10.1037//0882-7974.10.1.64
   Seltzer MM, 2004, AM J ORTHOPSYCHIAT, V74, P187, DOI 10.1037/0002-9432.74.2.187
   Singer J. D., 2003, APPL LONGITUDINAL DA
   Skinner EA, 2003, PSYCHOL BULL, V129, P216, DOI 10.1037/0033-2909.129.2.216
   Smith LE, 2008, J AUTISM DEV DISORD, V38, P876, DOI 10.1007/s10803-007-0461-6
   SNIJDERS TAB, 1994, SOCIOL METHOD RES, V22, P342, DOI 10.1177/0049124194022003004
   THOITS PA, 1995, J HLTH SOCIAL BEHAV, P53, DOI DOI 10.2307/2626957
   Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
   Weiss JA, 2013, RES AUTISM SPECT DIS, V7, P1310, DOI 10.1016/j.rasd.2013.07.016
   Whittingham K, 2014, MINDFULNESS, V5, P704, DOI 10.1007/s12671-013-0224-8
   Willett JB, 1998, DEV PSYCHOPATHOL, V10, P395, DOI 10.1017/S0954579498001667
   Woodman A. C., 2012, J INTELL DISABIL RES, V57, P513
   Yatchmenoff D. K., 1998, J CHILD FAM STUD, V7, P129, DOI 10.1023/A:1022935014502
   Zhang W, 2013, RES AUTISM SPECT DIS, V7, P1204, DOI 10.1016/j.rasd.2013.07.008
NR 77
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1793
EP 1807
DI 10.1007/s10803-014-2079-9
PG 15
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400001
PM 24599424
ER

PT J
AU Jensen, CM
   Steinhausen, HC
   Lauritsen, MB
AF Jensen, Christina Mohr
   Steinhausen, Hans-Christoph
   Lauritsen, Marlene Briciet
TI Time Trends Over 16 Years in Incidence-Rates of Autism Spectrum
   Disorders Across the Lifespan Based on Nationwide Danish Register Data
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Autism; Incidence; Time-trend
ID PERVASIVE DEVELOPMENTAL DISORDERS; OLMSTED COUNTY; BIRTH COHORTS;
   DIAGNOSIS; CHILDREN; POPULATION; PREVALENCE; AGE; CALIFORNIA; MINNESOTA
AB This study investigated time trends and associated factors of incidence rates of diagnosed autism spectrum disorders (ASD) across the lifespan from 1995 to 2010, using data from the Danish Psychiatric Central Research Registry. First time diagnosis of childhood autism, atypical autism, Asperger's syndrome, or pervasive developmental disorder-unspecified (PDD-NOS) were identified, incidence rates were calculated, and data were fitted using non-linear least squares methods. A total of 14.997 patients were identified and incidence rates for ASD increased from 9.0 to 38.6 per 100,000 person years during the 16-year period. The increases were most pronounced in females, adolescents, adults, and patients with Asperger's syndrome and PDD-NOS.
C1 [Jensen, Christina Mohr; Steinhausen, Hans-Christoph; Lauritsen, Marlene Briciet] Aalborg Univ Hosp, Res Unit Child & Adolescent Psychiat, Aalborg Psychiat Hosp, DK-9000 Aalborg, Denmark.
   [Steinhausen, Hans-Christoph] Univ Basel, Inst Psychol, Basel, Switzerland.
   [Steinhausen, Hans-Christoph] Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland.
RP Jensen, CM (reprint author), Aalborg Univ Hosp, Res Unit Child & Adolescent Psychiat, Aalborg Psychiat Hosp, Molleparkvej 10, DK-9000 Aalborg, Denmark.
EM christina.j@rn.dk
CR Atladottir HO, 2007, ARCH PEDIAT ADOL MED, V161, P193, DOI 10.1001/archpedi.161.2.193
   Barbaresi WJ, 2005, ARCH PEDIAT ADOL MED, V159, P37, DOI 10.1001/archpedi.159.1.37
   Barbaresi WJ, 2009, J AUTISM DEV DISORD, V39, P464, DOI 10.1007/s10803-008-0645-8
   Burstyn I, 2010, CHRONIC DIS CAN, V30, P125
   Chien IC, 2011, J CHILD NEUROL, V26, P830, DOI 10.1177/0883073810393964
   Davidovitch M, 2001, ISRAEL MED ASSOC J, V3, P188
   Davidovitch M, 2013, J AUTISM DEV DISORD, V43, P785, DOI 10.1007/s10803-012-1611-z
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Feng L, 2013, ASIA-PAC PSYCHIAT, V5, P54, DOI 10.1111/appy.12079
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Fountain C, 2011, J EPIDEMIOL COMMUN H, V65, P503, DOI 10.1136/jech.2009.104588
   Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
   Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
   Keyes KM, 2012, INT J EPIDEMIOL, V41, P495, DOI 10.1093/ije/dyr193
   Kielinen M, 2000, EUR CHILD ADOLES PSY, V9, P162
   Kirkovski M, 2013, J AUTISM DEV DISORD, V43, P2584, DOI 10.1007/s10803-013-1811-1
   Kopp S, 2010, J ATTEN DISORD, V14, P167, DOI 10.1177/1087054709332458
   Lauritsen MB, 2004, PSYCHOL MED, V34, P1339, DOI 10.1017/S0033291704002387
   Lauritsen MB, 2010, J AUTISM DEV DISORD, V40, P139, DOI 10.1007/s10803-009-0818-0
   Liu KY, 2010, AM J SOCIOL, V115, P1387
   Manning SE, 2011, PEDIATRICS, V127, P1043, DOI 10.1542/peds.2010-2943
   Munk-Jorgensen P, 2011, SCAND J PUBLIC HEALT, V39, P170, DOI 10.1177/1403494810390728
   Nassar N, 2009, INT J EPIDEMIOL, V38, P1245, DOI 10.1093/ije/dyp260
   Parner ET, 2008, ARCH PEDIAT ADOL MED, V162, P1150, DOI 10.1001/archpedi.162.12.1150
   Powell JE, 2000, DEV MED CHILD NEUROL, V42, P624, DOI 10.1017/S001216220000116X
   Smeeth L, 2004, BMC MED, V2, DOI 10.1186/1741-7015-2-39
   STATA, 2012, STATA DAT AN STAT SO
   van der Ven E, 2013, ACTA PSYCHIAT SCAND, V128, P54, DOI 10.1111/acps.12054
   Van Meter KC, 2010, AUTISM RES, V3, P19, DOI 10.1002/aur.110
   Wazana A, 2007, J AM ACAD CHILD PSY, V46, P721, DOI 10.1097/chi.0b013e31804a7f3b
   Williams K, 2005, MED J AUSTRALIA, V182, P108
   Wong VCN, 2008, J CHILD NEUROL, V23, P67, DOI 10.1177/0883073807308702
NR 32
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1808
EP 1818
DI 10.1007/s10803-014-2053-6
PG 11
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400002
PM 24554161
ER

PT J
AU Harper-Hill, K
   Copland, D
   Arnott, W
AF Harper-Hill, Keely
   Copland, David
   Arnott, Wendy
TI Efficiency of Lexical Access in Children with Autism Spectrum Disorders:
   Does Modality Matter?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Children; Language; Semantic priming; Retrospective semantic matching;
   Attention; Visual support; Autism spectrum disorders
ID HIGH-FUNCTIONING AUTISM; LANGUAGE IMPAIRMENT; YOUNG-CHILDREN; LARGE SET;
   ADULTS; DECISION; SPEECH; WORDS; COMPREHENSION; MEMORY
AB The provision of visual support to individuals with an autism spectrum disorder (ASD) is widely recommended. We explored one mechanism underlying the use of visual supports: efficiency of language processing. Two groups of children, one with and one without an ASD, participated. The groups had comparable oral and written language skills and nonverbal cognitive abilities. In two semantic priming experiments, prime modality and prime-target relatedness were manipulated. Response time and accuracy of lexical decisions on the spoken word targets were measured. In the first uni-modal experiment, both groups demonstrated significant priming effects. In the second experiment which was cross-modal, no effect for relatedness or group was found. This result is considered in the light of the attentional capacity required for access to the lexicon via written stimuli within the developing semantic system. These preliminary findings are also considered with respect to the use of visual support for children with ASD.
C1 [Harper-Hill, Keely; Copland, David] Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia.
   [Harper-Hill, Keely; Copland, David; Arnott, Wendy] Univ Queensland, Sch Hlth & Rehabil, Div Speech Pathol, Brisbane, Qld, Australia.
RP Harper-Hill, K (reprint author), Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia.
EM k.harperhill@uq.edu.au
RI Copland, David/F-1409-2010
OI Copland, David/0000-0002-2257-4270
CR Australian Bureau of Statistics, 2006, 2033055001 CENS POP
   Balota DA, 2007, BEHAV RES METHODS, V39, P445, DOI 10.3758/BF03193014
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   Bonnotte I, 2010, EUR J DEV PSYCHOL, V7, P309, DOI 10.1080/17405620802114546
   Brand-D'Abrescia M, 2008, PERCEPT PSYCHOPHYS, V70, P508, DOI 10.3758/PP.70.3.508
   Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007
   Bruneau N, 1999, CLIN NEUROPHYSIOL, V110, P1927, DOI 10.1016/S1388-2457(99)00149-2
   Bruneau N, 2003, INT J PSYCHOPHYSIOL, V51, P17, DOI 10.1016/S0167-8760(03)00149-1
   Brysbaert M., 2007, LANGUAGE FIXED EFFEC
   Carlesimo GA, 2000, CORTEX, V36, P181, DOI 10.1016/S0010-9452(08)70523-9
   Carlesimo GA, 2004, NEUROPSYCHOLOGIA, V42, P14, DOI 10.1016/S0028-3932(03)00148-9
   Castles A, 2003, Q J EXP PSYCHOL-A, V56, P445, DOI 10.1080/02724980244000486
   Ceponiene R, 2003, P NATL ACAD SCI USA, V100, P5567, DOI 10.1073/pnas.0835631100
   Cree GS, 1999, COGNITIVE SCI, V23, P371, DOI 10.1016/S0364-0213(99)00005-1
   DEGROOT AMB, 1986, ACTA PSYCHOL, V61, P17, DOI 10.1016/0001-6918(86)90019-3
   DeLemos M. M., 1994, STANDARD PROGR MATRI
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   Dunn M, 1999, DEV NEUROPSYCHOL, V16, P79, DOI 10.1207/S15326942DN160105
   ESKES GA, 1990, J AUTISM DEV DISORD, V20, P61, DOI 10.1007/BF02206857
   Forsey J, 1996, J AUTISM DEV DISORD, V26, P643, DOI 10.1007/BF02172353
   Fritz JB, 2007, CURR OPIN NEUROBIOL, V17, P437, DOI 10.1016/j.conb.2007.07.011
   Gardiner JM, 2003, J AUTISM DEV DISORD, V33, P259, DOI 10.1023/A:1024450416355
   Girbau D, 2011, SPAN J PSYCHOL, V14, P4, DOI 10.5209/rev_SJOP.2011.v14.n1.1
   Hala S, 2007, J AUTISM DEV DISORD, V37, P329, DOI 10.1007/s10803-006-0162-6
   Harris M, 1986, LANGUAGE PROCESSING
   Hashimoto N, 2007, J SPEECH LANG HEAR R, V50, P161, DOI 10.1044/1092-4388(2007/014)
   Henderson LM, 2011, J CHILD PSYCHOL PSYC, V52, P964, DOI 10.1111/j.1469-7610.2011.02393.x
   Hodgdon L., 1999, VISUAL STRATEGIES IM
   Howlin P, 1997, EUR CHILD ADOLES PSY, V6, P55
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   KAIL R, 1992, DEV PSYCHOL, V28, P899, DOI 10.1037//0012-1649.28.5.899
   Kamio Y, 2007, J AUTISM DEV DISORD, V37, P1116, DOI 10.1007/s10803-006-0254-3
   Kamio Y, 2000, J CHILD PSYCHOL PSYC, V41, P859, DOI 10.1017/S0021963099006137
   KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995
   Lord C., 1998, AUTISM DIAGNOSTIC OB
   Lukas S, 2010, ACTA PSYCHOL, V134, P318, DOI 10.1016/j.actpsy.2010.03.004
   Lukas S, 2010, PSYCHOL RES-PSYCH FO, V74, P255, DOI 10.1007/s00426-009-0246-y
   MANIS FR, 1980, J EXP CHILD PSYCHOL, V29, P156, DOI 10.1016/0022-0965(80)90098-3
   Manly T., 1999, TEST EVERYDAY ATTENT
   Marcus LM, 2001, RESEARCH BASIS FOR AUTISM INTERVENTION, P171
   Marinelli CV, 2011, NEUROPSYCHOLOGIA, V49, P1718, DOI 10.1016/j.neuropsychologia.2011.02.050
   Martens VEG, 2006, BRAIN LANG, V98, P140, DOI 10.1016/j.bandl.2006.04.003
   McCleery JP, 2010, J CHILD PSYCHOL PSYC, V51, P277, DOI 10.1111/j.1469-7610.2009.02157.x
   McRae K, 2005, BEHAV RES METHODS, V37, P547, DOI 10.3758/BF03192726
   McRae K, 1998, J EXP PSYCHOL LEARN, V24, P558, DOI 10.1037//0278-7393.24.3.558
   Mirenda P., 2001, FOCUS AUTISM OTHER D, V16, P141, DOI DOI 10.1177/108835760101600302
   Morrison CM, 1997, Q J EXP PSYCHOL-A, V50, P528
   Nation K, 1998, J MEM LANG, V39, P85, DOI 10.1006/jmla.1998.2564
   Neely J. H., 1991, BASIC PROCESSES READ, P264
   NEELY JH, 1977, J EXP PSYCHOL GEN, V106, P226, DOI 10.1037/0096-3445.106.3.226
   Nelson C, 2007, EDUC TRAIN DEV DISAB, V42, P165
   Nelson J. R., 2005, WRITTEN LANGUAGE LIT, V8, P25, DOI DOI 10.1075/WLL.8.2.04NEL
   O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543
   Plaisted K, 2003, PHILOS T ROY SOC B, V358, P375, DOI 10.1098/rstb.2002.1211
   Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613
   PRATARELLI ME, 1994, J EXP CHILD PSYCHOL, V58, P346, DOI 10.1006/jecp.1994.1039
   Prior M., 2011, REV RES IDENTIFY MOS
   Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
   RADEAU M, 1983, CAN J PSYCHOL, V37, P547, DOI 10.1037/h0080756
   Rao S., 2006, TEACHING EXCEPTIONAL, V38, P26
   Rastle K, 2002, Q J EXP PSYCHOL-A, V55, P1339, DOI 10.1080/02724980244000099
   Raven J., 1998, COLOURED PROGR MATRI, V2
   Raven J, 2000, STANDARD PROGR MATRI
   Roberts J. M. A., 2006, REV RES IDENTIFY MOS
   Russo N, 2009, J AUTISM DEV DISORD, V39, P1185, DOI 10.1007/s10803-009-0737-0
   Schopler E., 1995, LEARNING COGNITION A, P3
   Seiger-Gardner L, 2008, INT J LANG COMM DIS, V43, P528, DOI 10.1080/13682820701768581
   Semel E., 2003, CLIN EVALUATION LANG, V4th
   SNEDECOR G.W., 1989, STAT METHODS, V8th
   Spears C., 2011, RISING NEW HEIGHTS C
   Tabachnick B., 2007, USING MULTIVARIATE S, V5th
   Taft M., 2001, INT ENCY SOCIAL BEHA, P8743
   Tager-Flusberg H, 2006, CLIN NEUROSCI RES, V6, P219, DOI 10.1016/j.cnr.2006.06.007
   TAGERFLUSBERG H, 1985, J EXP CHILD PSYCHOL, V40, P450, DOI 10.1016/0022-0965(85)90077-3
   Toichi M, 2001, J AUTISM DEV DISORD, V31, P483, DOI 10.1023/A:1012216925216
   Toichi M, 2002, NEUROPSYCHOLOGIA, V40, P964, DOI 10.1016/S0028-3932(01)00163-4
   Tse CS, 2007, J EXP PSYCHOL LEARN, V33, P1143, DOI 10.1037/0278-7393.33.6.1143
   van den Boer M, 2012, Q J EXP PSYCHOL, V65, P1214, DOI 10.1080/17470218.2011.652136
   Van Overschelde JP, 2004, J MEM LANG, V50, P289, DOI 10.1016/j.jml.2003.10.003
   Wang SH, 2009, NEUROREPORT, V20, P574, DOI 10.1097/WNR.0b013e328329f215
   Whitehouse AJO, 2008, BRAIN, V131, P3193, DOI 10.1093/brain/awn266
   Woodcock R. W., 2004, WOODCOCK JOHNSON 3
NR 82
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1819
EP 1832
DI 10.1007/s10803-014-2055-4
PG 14
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400003
PM 24519698
ER

PT J
AU Fatemi, SH
   Reutiman, TJ
   Folsom, TD
   Rustan, OG
   Rooney, RJ
   Thuras, PD
AF Fatemi, S. Hossein
   Reutiman, Teri J.
   Folsom, Timothy D.
   Rustan, Oyvind G.
   Rooney, Robert J.
   Thuras, Paul D.
TI Downregulation of GABA(A) Receptor Protein Subunits alpha 6, beta 2,
   delta, epsilon, gamma 2, theta, and rho 2 in Superior Frontal Cortex of
   Subjects with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; GABA; Brain; GABR alpha 6; Frontal cortex; GABR beta 2
ID FRAGILE-X-SYNDROME; MENTAL-RETARDATION PROTEIN; IN-SITU HYBRIDIZATION;
   MESSENGER-RNA LEVELS; SPECTRUM DISORDERS; RAT-BRAIN; CHROMOSOME
   15Q11-Q13; SIGNIFICANT ASSOCIATION; POSTMORTEM BRAIN; GENE-EXPRESSION
AB We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABA(A)) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABA(A) and GABA(B) subunits and overall reduced protein expression for GABA(A) receptor alpha 6 (GABR alpha 6), GABA(A) receptor beta 2 (GABR beta 2), GABA(A) receptor delta (GABR delta), GABA(A) receptor epsilon (GABR epsilon), GABA(A) receptor gamma 2 (GABR gamma 2), GABA(A) receptor theta (GABR theta), and GABA(A) receptor rho 2 (GABR rho 2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABA(A&B) subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism.
C1 [Fatemi, S. Hossein; Folsom, Timothy D.] Univ Minnesota, Div Neurosci Res, Dept Psychiat, Sch Med, Minneapolis, MN 55455 USA.
   [Fatemi, S. Hossein] Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA.
   [Fatemi, S. Hossein] Univ Minnesota, Dept Neurosci, Sch Med, Minneapolis, MN 55455 USA.
   [Rooney, Robert J.] Genome Explorat, Memphis, TN 84322 USA.
   [Thuras, Paul D.] Minneapolis Vet Adm Med Ctr, Dept Psychiat 116A, Minneapolis, MN 55417 USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Div Neurosci Res, Dept Psychiat, Sch Med, 420 Delaware St SE,MMC 392, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
CR Abdolmaleky H. M., 2009, PHARMACOGENOMICS DRU, V448, P187
   Akbarian S, 2009, BIOL PSYCHIAT, V65, P198, DOI 10.1016/j.biopsych.2008.08.015
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
   Arias B, 2012, ACTA PSYCHIAT SCAND, V125, P194, DOI 10.1111/j.1600-0447.2011.01764.x
   Banerjee A., 2012, INT J NEUROPSYCHOPH, V11, P1
   Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666
   Bonnert TP, 1999, P NATL ACAD SCI USA, V96, P9891, DOI 10.1073/pnas.96.17.9891
   Brandon N. J., 2000, GABAA NERVOUS SYSTEM, P196
   Canitano R, 2013, BEHAV BRAIN RES, V251, P125, DOI 10.1016/j.bbr.2012.11.024
   Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005
   CUTTING GR, 1992, GENOMICS, V12, P801, DOI 10.1016/0888-7543(92)90312-G
   D'Hulst C, 2006, BRAIN RES, V1121, P238, DOI 10.1016/j.brainres.2006.08.115
   Dibbens LM, 2004, HUM MOL GENET, V13, P1315, DOI 10.1093/hmg/ddh146
   El Idrissi A, 2005, NEUROSCI LETT, V377, P141, DOI 10.1016/j.neulet.2004.11.087
   Emberger W, 2000, CYTOGENET CELL GENET, V89, P281, DOI 10.1159/000015636
   Erickson CA, 2013, PSYCHOPHARMACOLOGY, V228, P75, DOI 10.1007/s00213-013-3022-z
   Fatemi SH, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-6
   Fatemi S. H., 2013, TRANSL PSYCHIAT, V3, pe27
   Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
   Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3
   Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
   Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Feng Y, 2010, GENES BRAIN BEHAV, V9, P668, DOI 10.1111/j.1601-183X.2010.00598.x
   Fombonne E., 2006, UNDERSTANDING AUTISM, P25
   Gantois I, 2006, NEUROBIOL DIS, V21, P346, DOI 10.1016/j.nbd.2005.07.017
   Grayson DR, 2006, PHARMACOL THERAPEUT, V111, P272, DOI 10.1016/j.pharmthera.2005.01.007
   GREGER V, 1995, GENOMICS, V26, P258, DOI 10.1016/0888-7543(95)80209-5
   Guptill JT, 2007, J AUTISM DEV DISORD, V37, P911, DOI 10.1007/s10803-006-0226-7
   Gurkan CK, 2012, RES AUTISM SPECT DIS, V6, P1311, DOI DOI 10.1016/J.RASD.2012.05.007
   Hagerman R, 2012, RESULTS PROBL CELL D, V54, P297, DOI 10.1007/978-3-642-21649-7_17
   Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286
   Hernandez C. C., 2012, J PHYSL, V589, P5857
   HICKS AA, 1994, GENOMICS, V20, P285, DOI 10.1006/geno.1994.1167
   Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014
   Hong A, 2012, J MOL NEUROSCI, V46, P272, DOI 10.1007/s12031-011-9531-5
   Ito M, 2005, NEUROSCI LETT, V383, P220, DOI 10.1016/j.neulet.2005.04.017
   Jones KA, 1998, NATURE, V396, P674, DOI 10.1038/25348
   Kelemenova S, 2010, PSYCHIAT GENET, V20, P137, DOI 10.1097/YPG.0b013e32833a1eb3
   Khan Z, 2013, SCIENCE, V342, P1100, DOI 10.1126/science.1242379
   Korpi ER, 2002, PROG NEUROBIOL, V67, P113, DOI 10.1016/S0301-0082(02)00013-8
   Kumari R, 2011, CLIN CHIM ACTA, V412, P1244, DOI 10.1016/j.cca.2011.03.018
   LAURIE DJ, 1992, J NEUROSCI, V12, P1063
   Lenzen KP, 2005, EPILEPSY RES, V65, P53, DOI 10.1016/j.eplepsyres.2005.04.005
   Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
   Maddox LO, 1999, GENOMICS, V62, P325, DOI 10.1006/geno.1999.6017
   McCauley JL, 2004, AM J MED GENET B, V131B, P51, DOI 10.1002/ajmg.b.30038
   Menold MM, 2001, J NEUROGENET, V15, P245
   Moragues N, 2000, EUR J NEUROSCI, V12, P4318, DOI 10.1111/j.1460-9568.2000.01343.x
   Oblak AL, 2011, BRAIN RES, V1380, P218, DOI 10.1016/j.brainres.2010.09.021
   Oblak AL, 2010, J NEUROCHEM, V114, P1414, DOI 10.1111/j.1471-4159.2010.06858.x
   Pham X, 2009, DEPRESS ANXIETY, V26, P998, DOI 10.1002/da.20628
   Pirker S, 2000, NEUROSCIENCE, V101, P815, DOI 10.1016/S0306-4522(00)00442-5
   Pirker S, 2003, J NEUROPATH EXP NEUR, V62, P820
   Piton A., 2013, EUROPEAN J IN PRESS
   Purcell AE, 2001, NEUROLOGY, V57, P1618
   Represa A, 2005, TRENDS NEUROSCI, V28, P278, DOI 10.1016/j.tins.2005.03.010
   Russ SA, 2012, PEDIATRICS, V129, P256, DOI 10.1542/peds.2010-1371
   Russek SJ, 1995, CELL MOL BIOL RES, V41, P511
   Rustan OG, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-41
   Sasaki K, 2009, PEDIATR NEUROL, V41, P114, DOI 10.1016/j.pediatrneurol.2009.03.003
   Schwarzer C, 2001, J COMP NEUROL, V433, P526, DOI 10.1002/cne.1158
   Sokol DK, 2011, NEUROLOGY, V76, P1344, DOI 10.1212/WNL.0b013e3182166dc7
   Suren P, 2013, JAMA-J AM MED ASSOC, V309, P570, DOI 10.1001/jama.2012.155925
   Tochigi M, 2007, J HUM GENET, V52, P985, DOI 10.1007/s10038-007-0207-5
   Tucholski J, 2013, SCHIZOPHR RES, V146, P177, DOI 10.1016/j.schres.2013.01.031
   Vasquez K, 2013, ADV EXP MED BIOL, V775, P101, DOI 10.1007/978-1-4614-6130-2_8
   Vogel C, 2013, SCIENCE, V342, P1052, DOI 10.1126/science.1247833
   Wang KS, 2010, SCHIZOPHR RES, V124, P192, DOI 10.1016/j.schres.2010.09.002
   Wang LW, 2010, NEUROTHERAPEUTICS, V7, P264, DOI 10.1016/j.nurt.2010.05.005
   WILCOX AS, 1992, P NATL ACAD SCI USA, V89, P5857, DOI 10.1073/pnas.89.13.5857
   Wilke K, 1997, GENOMICS, V45, P1, DOI 10.1006/geno.1997.4885
   WISDEN W, 1992, J NEUROSCI, V12, P1040
   Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
   Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62
   Yoo HK, 2009, YONSEI MED J, V50, P304, DOI 10.3349/ymj.2009.50.2.304
   Zhang C, 2009, J NEUROSCI, V29, P10843, DOI 10.1523/JNEUROSCI.1248-09.2009
   Zhao J, 2012, J AFFECT DISORDERS, V138, P494, DOI 10.1016/j.jad.2012.01.013
NR 79
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1833
EP 1845
DI 10.1007/s10803-014-2078-x
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400004
PM 24668190
ER

PT J
AU Jameel, L
   Vyas, K
   Bellesi, G
   Roberts, V
   Channon, S
AF Jameel, Leila
   Vyas, Karishma
   Bellesi, Giulia
   Roberts, Victoria
   Channon, Shelley
TI Going 'Above and Beyond': Are Those High in Autistic Traits Less
   Pro-social?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autistic traits; Pro-social behaviour; Empathy; Perspective-taking;
   Theory of mind
ID MIRROR-NEURON SYSTEM; SPECTRUM QUOTIENT AQ; ASPERGERS-SYNDROME;
   FUNCTIONING AUTISM; COGNITIVE-STYLE; SKILLS GROUP; MIND; CHILDREN;
   BEHAVIOR; EMPATHY
AB Few studies have explored how the cognitive differences associated with autistic spectrum disorder translate into everyday social behaviour. This study investigated pro-social behaviour in students scoring high and low on the autism-spectrum quotient (AQ), using a novel scenario task: 'Above and Beyond'. Each scenario involved an opportunity to behave pro-socially, and thus required balancing the needs of a character against participants' own interests. High AQ participants both generated responses and selected courses of action that were less pro-social than those of the low AQ group. For actions of low pro-social value they gave higher self-satisfaction ratings; conversely, they gave lower self-satisfaction ratings for high pro-social actions. The implications for everyday functioning are considered for those with high autistic traits.
C1 [Jameel, Leila; Vyas, Karishma; Bellesi, Giulia; Roberts, Victoria; Channon, Shelley] Univ Coll London, Dept Cognit Perceptual & Brain Sci, Bedford WC1E 6BT, England.
RP Jameel, L (reprint author), Univ Coll London, Dept Cognit Perceptual & Brain Sci, Bedford Way Bldg,Gower St, Bedford WC1E 6BT, England.
EM l.jameel@ucl.ac.uk
CR Almeida R. A., 2012, J AUTISM DEV DISORD, V43, P1, DOI DOI 10.1007/S10803-012-1669-7
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   [Anonymous], 1991, ALTRUISM QUESTION
   Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Barry TD, 2003, J AUTISM DEV DISORD, V33, P685, DOI 10.1023/B:JADD.0000006004.86556.e0
   Batson C. D., 1987, ADV EXPT SOCIAL PSYC
   Bayliss AP, 2011, J AUTISM DEV DISORD, V41, P1573, DOI 10.1007/s10803-010-1159-8
   Blair RJR, 2008, Q J EXP PSYCHOL, V61, P157, DOI 10.1080/17470210701508855
   BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
   BRIEF AP, 1986, ACAD MANAGE REV, V11, P710, DOI 10.2307/258391
   Burnett HG, 2013, J AUTISM DEV DISORD, V43, P211, DOI 10.1007/s10803-012-1567-z
   Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002
   CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
   Carroll JM, 2006, J AUTISM DEV DISORD, V36, P949, DOI 10.1007/s10803-006-0127-9
   Channon S, 2014, COGN NEUROPSYCHIATRY, V19, P149, DOI 10.1080/13546805.2013.809659
   Channon S, 2001, J AUTISM DEV DISORD, V31, P461, DOI 10.1023/A:1012212824307
   Channon S, 2012, J AUTISM DEV DISORD, V42, P1425, DOI 10.1007/s10803-011-1381-z
   Channon S, 2010, J AUTISM DEV DISORD, V40, P1219, DOI 10.1007/s10803-010-0980-4
   Coie JD, 1990, PEER REJECTION CHILD, P17
   COKE JS, 1978, J PERS SOC PSYCHOL, V36, P752, DOI 10.1037//0022-3514.36.7.752
   Cooper NR, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00159
   DAWSON G, 1987, J AUTISM DEV DISORD, V17, P487, DOI 10.1007/BF01486965
   De Martino B, 2008, J NEUROSCI, V28, P10746, DOI 10.1523/JNEUROSCI.2895-08.2008
   Eisenberg N, 2003, CROSS CONT, P253
   EISENBERG N, 1989, J PERS SOC PSYCHOL, V57, P55, DOI 10.1037//0022-3514.57.1.55
   Eisenberg Nancy, 2007, Novartis Found Symp, V278, P71
   EISENBERG N, 1987, PSYCHOL BULL, V101, P91, DOI 10.1037/0033-2909.101.1.91
   Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X
   Frith U, 2005, CONSCIOUS COGN, V14, P719, DOI 10.1016/j.concog.2005.04.006
   FRITH U, 1989, DIAGNOSIS AND TREATMENT OF AUTISM, P33
   Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x
   Frith U., 2003, AUTISM EXPLAINING EN
   Frith U, 1999, MIND LANG, V14, P1
   Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
   Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
   Gray C. A., 1995, TEACHING CHILDREN AU, P214
   Grinter EJ, 2009, J AUTISM DEV DISORD, V39, P1278, DOI 10.1007/s10803-009-0740-5
   Hale CM, 2005, AUTISM, V9, P157, DOI 10.1177/1362361305051395
   Hamilton AFD, 2006, J NEUROSCI, V26, P1133, DOI 10.1523/JNEUROSCI.4551-05.2006
   Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Harris P. L., 2000, UNDERSTANDING OTHER, P182
   Heavey L, 2000, J AUTISM DEV DISORD, V30, P225, DOI 10.1023/A:1005544518785
   Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
   Hill EL, 2003, PHILOS T R SOC B, V358, P281, DOI 10.1098/rstb.2002.1209
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Hillier A, 2002, J AUTISM DEV DISORD, V32, P583, DOI 10.1023/A:1021259115185
   Hoffman ML, 2001, EMPATHY MORAL DEV IM
   Howlin P., 1999, AUTISM, V3, P299, DOI DOI 10.1177/1362361399003003007
   Howlin P, 2004, AUTISM ASPERGER SYND
   Hudson M, 2012, J AUTISM DEV DISORD, V42, P2534, DOI 10.1007/s10803-012-1510-3
   Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
   Izuma K, 2011, P NATL ACAD SCI USA, V108, P17302, DOI 10.1073/pnas.1107038108
   Joliffe T., 1999, COGNITION, V71, P149
   KAMPS DM, 1992, J APPL BEHAV ANAL, V25, P281, DOI 10.1901/jaba.1992.25-281
   Lawson J, 2004, J AUTISM DEV DISORD, V34, P301, DOI 10.1023/B:JADD.0000029552.42724.1b
   Lin A, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-8
   Manson C, 2012, EDUC STUD-UK, V38, P73, DOI 10.1080/03055698.2011.567032
   MARRIAGE KJ, 1995, AUST NZ J PSYCHIAT, V29, P58, DOI 10.3109/00048679509075892
   Martin I, 2004, J AUTISM DEV DISORD, V34, P311, DOI 10.1023/B:JADD.0000029553.52889.15
   McGregor E., 1998, AUTISM, V2, P4367
   Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006
   Mueser K. T., 2007, J MENTAL HLTH, V16, P549, DOI 10.1080/09638230701494951
   Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
   Poljac E., 2012, AUTISM, V17, P668
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   PUFFER SM, 1987, J APPL PSYCHOL, V72, P615, DOI 10.1037//0021-9010.72.4.615
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Reichow Brian, 2013, Evid Based Child Health, V8, P266, DOI 10.1002/ebch.1903
   RICHER J, 1976, ANIM BEHAV, V24, P898, DOI 10.1016/S0003-3472(76)80020-6
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
   RUTTER M, 1978, J AUTISM CHILD SCHIZ, V8, P139, DOI 10.1007/BF01537863
   Samson D, 2005, BRAIN, V128, P1102, DOI 10.1093/brain/awh464
   Samson D, 2010, J EXP PSYCHOL HUMAN, V36, P1255, DOI 10.1037/a0018729
   SCHALLER M, 1988, J EXP SOC PSYCHOL, V24, P163, DOI 10.1016/0022-1031(88)90019-4
   Schreiber C., 2011, J POSIT BEHAV INTERV, V13, P149
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
   Southgate V, 2008, TRENDS COGN SCI, V12, P225, DOI 10.1016/j.tics.2008.03.005
   Spek AA, 2010, J AUTISM DEV DISORD, V40, P280, DOI 10.1007/s10803-009-0860-y
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Sze J. A., 2011, EMOTION, V12, P1129
   Travis L, 2001, J AUTISM DEV DISORD, V31, P119, DOI 10.1023/A:1010705912731
   Travis LL, 1998, MENT RETARD DEV D R, V4, P65, DOI 10.1002/(SICI)1098-2779(1998)4:2<65::AID-MRDD2>3.0.CO;2-W
   van Boxtel JJA, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00209
   White SJ, 2009, AUTISM RES, V2, P138, DOI 10.1002/aur.78
   White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Yang D. Y. J., 2013, J AUTISM DEV DISORD, V43, P1
   Zeeland S.-V., 2010, AUTISM RES, V3, P53, DOI DOI 10.1002/AUR.122
NR 99
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1846
EP 1858
DI 10.1007/s10803-014-2056-3
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400005
PM 24522968
ER

PT J
AU Hathorn, C
   Alateeqi, N
   Graham, C
   O'Hare, A
AF Hathorn, Claire
   Alateeqi, Nahed
   Graham, Catriona
   O'Hare, Anne
TI Impact of Adherence to Best Practice Guidelines on the Diagnostic and
   Assessment Services for Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Guidelines; Autism spectrum disorder; ASD specific history;
   Observational instruments; Paediatric medical training
ID ASPERGER-SYNDROME; RISK-FACTORS; CHILDREN; COMMUNICATION; PREVALENCE;
   AGE; POPULATION; QUALITY; UTILITY; RATES
AB Despite their range and complexity, adherence to Scottish Intercollegiate Guidelines Network guideline for the diagnosis and assessment of autism spectrum disorders (ASD) was shown to be high within child development and specialist diagnostic clinics serving a geographical cohort of children diagnosed under the age of 7 years. A retrospective analysis of comprehensive clinical notes demonstrated that the recommended discretionary use of structured history instruments was increased after medical training (p = 0.003). 56 % (51/90) of children received the diagnosis of ASD at their initial specialist appointment. 51 % underwent the recommended discretionary structured observational instrument. This further assessment was more likely to be required for older children in the reaudited group (p = 0.001). The implications for service capacity planning when delivering best practice recommendations are discussed.
C1 [Hathorn, Claire] Royal Hosp Sick Children, Edinburgh EH9 1LF, Midlothian, Scotland.
   [Alateeqi, Nahed; O'Hare, Anne] Univ Edinburgh, Sch Clin Sci Child Life & Hlth, Edinburgh EH9 1UW, Midlothian, Scotland.
   [Graham, Catriona] Wellcome Trust Clin Res Facil, Edinburgh, Midlothian, Scotland.
RP O'Hare, A (reprint author), Univ Edinburgh, Sch Clin Sci Child Life & Hlth, 20 Sylvan Pl, Edinburgh EH9 1UW, Midlothian, Scotland.
EM aohare@ed.ac.uk
CR Academy of Medicine Singapore Ministry of Health Clinical Practice Guidelines Workgroup on Autism Spectrum Disorders, 2010, SINGAPORE MEDICAL JO, V51, P255
   AGREE Collaboration, 2003, QUALITY AND SAFETY I, V2, P18
   Aitken K., 1998, AUTISM, V2, P171, DOI 10.1177/1362361398022005
   American Academy of Paediatrics, 2011, PEDIATRICS, V127, pE857
   [Anonymous], 2001, PUBLIC HEALTH INSTIT
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baird G, 2008, J AUTISM DEV DISORD, V38, P1827, DOI 10.1007/s10803-008-0571-9
   Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
   Brock M, 2010, J INTELL DISABIL RES, V54, P894, DOI 10.1111/j.1365-2788.2010.01315.x
   Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
   Charman T, 2013, CHILD ADOL MENT H-UK, V18, P52, DOI 10.1111/j.1475-3588.2012.00664.x
   Constantino JN, 2002, SOCIAL RESPONSIVENES
   Coo H, 2012, CHRON DIS INJ CAN, V32, P90
   Davidoff MJ, 2006, SEMIN PERINATOL, V30, P8, DOI 10.1053/j.semperi.2006.01.009
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
   Gilberg C., 2006, JOURNAL OF CHILD PSY, V47, P167
   Gilliam J. E., 1995, GILLIAM AUTISM RATIN
   Goldman S., 2008, DEV MED CHILD NEUROL, V51, P30
   Harrison MJ, 2006, ARCH DIS CHILD, V91, P16, DOI 10.1136/adc.2004.049601
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Johnson S, 2011, ARCH DIS CHILD, V96, P73, DOI 10.1136/adc.2010.194795
   Keaney M, 1999, Int J Health Care Qual Assur Inc Leadersh Health Serv, V12, P314, DOI 10.1108/09526869910297331
   Liddle J., 1996, METHOD FOR EVALUATIN
   Lord C., 2002, JOURNAL OF AUTISM AN, V24, P659
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   Mazefsky CA, 2006, AUTISM, V10, P533, DOI 10.1177/136236130606850S
   McConachie H, 2005, J AUTISM DEV DISORD, V35, P167, DOI 10.1007/s10803-005-1995-0
   Millard A, 1997, Int J Health Care Qual Assur Inc Leadersh Health Serv, V10, P236, DOI 10.1108/09526869710185003
   Ministries of Health and Education, 2008, NEW ZEALAND AUTISM S
   National Autism Plan for Children. (NAP-C), 2003, PLAN FOR IDENTIFICAT
   National Institute for Health and Clinical Excellence (NICE), 2012, AUTISM RECOGNITION R
   National Institute for Health and Clinical Excellence (NICE), 2011, AUTISM RECOGNITION R
   New York State Department of Health Early Intervention Program, 1999, CLINICAL PRACTICE GU
   Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
   Palmer E, 2011, ARCH DIS CHILD, V96, P473, DOI 10.1136/adc.2009.172825
   Pandolfi V, 2010, J AUTISM DEV DISORD, V40, P1118, DOI 10.1007/s10803-010-0967-1
   Parner ET, 2011, J AUTISM DEV DISORD, V41, P1601, DOI 10.1007/s10803-011-1186-0
   QUINE L, 1994, J CHILD PSYCHOL PSYC, V35, P1273, DOI 10.1111/j.1469-7610.1994.tb01234.x
   Riou EM, 2009, DEV MED CHILD NEUROL, V51, P600, DOI 10.1111/j.1469-8749.2008.03197.x
   Sadiq FA, 2012, EUR CHILD ADOLES PSY, V21, P267, DOI 10.1007/s00787-012-0259-8
   Scottish Intercollegiate Guidelines Network (SIGN), 2008, GUID DEV HDB
   Shea BJ, 2007, BMC MED RES METHODOL, V7, DOI 10.1186/1471-2288-7-10
   SIGN 98, 2007, ASSESSMENT DIAGNOSIS
   Siklos S., 2006, RES DEV DISABIL, V28, P9
   Simonoff E, 2013, J CHILD PSYCHOL PSYC, V54, P186, DOI 10.1111/j.1469-7610.2012.02606.x
   Whiting PF, 2011, ANN INTERN MED, V155, P529, DOI [10.7326/0003-4819-155-8-201110180-00009, 10.1059/0003-4819-155-8-201110180-00009]
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
   World Health Organisation, 1993, THE INTERNATIONAL CL
NR 51
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1859
EP 1866
DI 10.1007/s10803-014-2057-2
PG 8
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400006
PM 24573334
ER

PT J
AU Mavropoulou, S
   Sideridis, GD
AF Mavropoulou, Sophia
   Sideridis, Georgios D.
TI Knowledge of Autism and Attitudes of Children Towards Their Partially
   Integrated Peers with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Peers; Partial integration; Knowledge; Attitudes; Empathy
ID COOPERATIVE LEARNING GROUPS; BEHAVIORAL INTENTIONS; SEVERE DISABILITIES;
   STUDENTS ATTITUDES; GENERAL-EDUCATION; CONTACT THEORY; EMPATHY SCALE;
   PLACEMENT; PROGRAMS; YOUTH
AB This study aimed to measure the effects of contact with integrated students with autism spectrum disorders (ASD) on the knowledge, attitudes and empathy of children (n = 224) from grades 4-6. A comparison group of children (n = 251) who had no contact with classmates with ASD was also included. All participants completed self-report instruments. The implementation of multilevel modeling and moderation analysis indicated significant effects on all dependent variables as well as differences across gender and grades. Implications are discussed regarding the role of contact on peers' conceptions of autism and their attitudes towards children with ASD within inclusionary settings.
C1 [Mavropoulou, Sophia] Univ Thessaly, Dept Special Educ, Volos 38221, Greece.
   [Sideridis, Georgios D.] Harvard Univ, Childrens Hosp, Clin Res Ctr, Sch Med, Boston, MA USA.
RP Mavropoulou, S (reprint author), Univ Thessaly, Dept Special Educ, Volos 38221, Greece.
EM smavrop@uth.gr; Georgios.Sideridis@childrens.harvard.edu
CR Agaliotis I., 2009, EUROPEAN J SPECIAL N, V24, P213, DOI [10.1080/08856250902793701, DOI 10.1080/08856250902793701]
   Ajzen I., 1980, UNDERSTANDING ATTITU
   Allport G. W., 1954, THE NATURE OF PREJUD
   Amaral D., 2011, AUTISM SPECTRUM DISO
   Anderson A, 2004, AUTISM, V8, P369, DOI 10.1177/1362361304045216
   Antonak RF, 2000, DISABIL REHABIL, V22, P211
   Batson C. D., 1987, EMPATHY ITS DEV, P163
   Bell SK, 2000, J PEDIATR PSYCHOL, V25, P137, DOI 10.1093/jpepsy/25.3.137
   BRYANT BK, 1982, CHILD DEV, V53, P413, DOI 10.1111/j.1467-8624.1982.tb01331.x
   Campbell J. M., 2007, RES DEV DISABIL, V29, P189
   Campbell JM, 2008, J AUTISM DEV DISORD, V38, P1598, DOI 10.1007/s10803-007-0534-6
   Campbell JM, 2011, J DEV PHYS DISABIL, V23, P377, DOI 10.1007/s10882-011-9234-4
   Campbell JM, 2011, J AUTISM DEV DISORD, V41, P732, DOI 10.1007/s10803-010-1092-x
   Campbell JM, 2004, RES DEV DISABIL, V25, P321, DOI 10.1016/j.ridd.2004.01.005
   Campbell JM, 2006, J DEV PHYS DISABIL, V18, P251, DOI 10.1007/s10882-006-9015-7
   Campbell JM, 2005, J DEV PHYS DISABIL, V17, P281, DOI 10.1007/s10882-005-4386-8
   Campbell JM, 2007, REM SPEC EDUC, V28, P163, DOI 10.1177/07419325070280030501
   Chaitken S., 1993, THE PSYCHOLOGY OF AT, P1
   Cohen D, 1996, DEV PSYCHOL, V32, P988, DOI 10.1037//0012-1649.32.6.988
   D'Ambrosio F, 2009, PERS INDIV DIFFER, V46, P160, DOI 10.1016/j.paid.2008.09.020
   de Boer A, 2012, EUR J PSYCHOL EDUC, V27, P573, DOI 10.1007/s10212-011-0096-z
   de Boer A, 2012, INT J DISABIL DEV ED, V59, P379, DOI 10.1080/1034912X.2012.723944
   Department for Children Schools& Families, 2008, SCHOOL CENSUS 2008
   Diamond K. E., 1994, EARLY ED DEV, V5, P301, DOI 10.1207/s15566935eed0504_5
   Diamond KE, 1997, TOP EARLY CHILD SPEC, V17, P520
   Dockrell J. E., 2002, APPL DEV PSYCHOL, V23, P409
   DUGAN E, 1995, J APPL BEHAV ANAL, V28, P175, DOI 10.1901/jaba.1995.28-175
   Eaves LC, 1997, J DEV PHYS DISABIL, V9, P277, DOI 10.1023/A:1024944226971
   Farrington D. P., 2006, JOURNAL OF ADOLESCEN, V29, P589
   Fisher M, 2002, RES PRACT PERS SEV D, V27, P165, DOI 10.2511/rpsd.27.3.165
   Fryxell D, 1995, J ASSOC PERS SEVERE, V20, P259
   Godeau E., 2010, DEV MED CHILD NEUROL, V52, P236, DOI DOI 10.1111/J.1469-8749.2010.03731.X
   Hunt P, 1997, J SPEC EDUC, V31, P3
   GOTTLIEB J, 1977, AM J MENT DEF, V82, P65
   Gray C., 2002, THE SIXTH SENSE
   Harris S. L., 1997, HDB AUTISM PERVASIVE, P665
   HARRIS SL, 1990, J AUTISM DEV DISORD, V20, P23, DOI 10.1007/BF02206854
   Harrower JK, 2001, BEHAV MODIF, V25, P762, DOI 10.1177/0145445501255006
   HOGAN R, 1969, J CONSULT CLIN PSYCH, V33, P307, DOI 10.1037/h0027580
   Humphrey N., 2008, SUPPORT LEARNING, V23, P41, DOI DOI 10.1111/11467-9604.2007.00367.X
   HUNT P, 1994, J ASSOC PERS SEVERE, V19, P200
   Jordan R., 2008, BRIT J SPECIAL ED, V35, P11, DOI 10.1111/j.1467-8578.2008.00364.x
   Kamps DM, 1995, BEHAV DISORDERS, V21, P89
   KAMPS DM, 1994, J APPL BEHAV ANAL, V27, P49, DOI 10.1901/jaba.1994.27-49
   Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
   Koegel L. K., 1996, POSITIVE BEHAV SUPPO, P305
   Manetti M, 2001, INT J BEHAV DEV, V25, P279
   Matsagouras I. G., 2006, EPITHEORISI EKPAIDEU, V11, P15
   Mesibov G. B., 1983, JOURNAL OF AUTISM AN, V26, P337
   Morgan SB, 1998, J PEDIATR PSYCHOL, V23, P367, DOI 10.1093/jpepsy/23.6.367
   Morrison K., 2007, RESEARCH METHODS IN
   Morton JE, 2008, RES DEV DISABIL, V29, P189, DOI 10.1016/j.ridd.2007.02.006
   CLUNIESROSS G, 1989, AUST PSYCHOL, V24, P273, DOI 10.1080/00050068908259566
   Ochs E, 2001, SOC DEV, V10, P399, DOI 10.1111/1467-9507.00172
   ODOM SL, 1986, J APPL BEHAV ANAL, V19, P59, DOI 10.1901/jaba.1986.19-59
   Roper P., 1990, DISABILITY HANDICAP, V5, P243, DOI 10.1080/02674649066780251
   Rosenbaum P. L., 1986, DEVELOPMENTAL AND BE, V29, P327
   Ross P, 2006, J INTELLECT DEV DIS, V31, P77, DOI 10.1080/13668250600710864
   Sandieson R., 2002, INT J DISABIL DEV ED, V49, P243, DOI [10.1080/1034912022000007270, DOI 10.1080/1034912022000007270]
   Schreibman L., 2005, THE SCIENCE AND THE
   Sciutto M, 2012, FOCUS AUTISM DEV DIS, V27, P177, DOI 10.1177/1088357612450511
   Siperstein GN, 2007, EXCEPT CHILDREN, V73, P435
   Slininger D, 2000, ADAPT PHYS ACT Q, V17, P176
   Spybrook J., 2011, OPTIMAL DESIGN PLUS
   Swaim KF, 2001, J AUTISM DEV DISORD, V31, P195, DOI 10.1023/A:1010703316365
   TOWNSEND MAR, 1993, J INTELL DISABIL RES, V37, P405
   Triandis H. C., 1971, ATTITUDES ATTITUDE C, P26
   TRIPP A, 1995, ADAPT PHYS ACT Q, V12, P323
   Vignes C, 2009, DEV MED CHILD NEUROL, V51, P473, DOI 10.1111/j.1469-8749.2009.03283.x
   Yeong S., 2012, TOPICS IN EARLY CHID, V32, P132
   Yuker H. E., 1988, ATTITUDES PERSONS DI, P262
NR 71
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1867
EP 1885
DI 10.1007/s10803-014-2059-0
PG 19
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400007
PM 24535575
ER

PT J
AU Lahera, G
   Boada, L
   Pousa, E
   Mirapeix, I
   Moron-Nozaleda, G
   Marinas, L
   Gisbert, L
   Pamias, M
   Parellada, M
AF Lahera, G.
   Boada, L.
   Pousa, E.
   Mirapeix, I.
   Moron-Nozaleda, G.
   Marinas, L.
   Gisbert, L.
   Pamias, M.
   Parellada, M.
TI Movie for the Assessment of Social Cognition (MASC): Spanish Validation
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social cognition; Theory of mind; Autism; Asperger syndrome; MASC
ID HIGH-FUNCTIONING AUTISM; BELIEF TASK-PERFORMANCE; PSYCHIATRY SCIP-S;
   ASPERGER-SYNDROME; AUTOBIOGRAPHICAL MEMORY; SPECTRUM DISORDERS; REVISED
   VERSION; NORMAL ADULTS; MIND; CHILDREN
AB We present the Spanish validation of the "Movie for the Assessment of Social Cognition" instrument (MASC-SP). We recruited 22 adolescents and young adults with Asperger syndrome and 26 participants with typical development. The MASC-SP and three other social cognition instruments (Ekman Pictures of Facial Affect test, Reading the Mind in the Eyes Test, and Happ,aEuro (TM) s Strange Stories) were administered to both groups. Individuals with Asperger syndrome had significantly lower scores in all measures of social cognition. The MASC-SP showed strong correlations with all three measures and relative independence of general cognitive functions. Internal consistency was optimal (0.86) and the test-retest was good. The MASC-SP is an ecologically valid and useful tool for assessing social cognition in the Spanish population.
C1 [Lahera, G.] Univ Alcala De Henares, Psychiat Med Special Dept, Fac Med, Madrid 28871, Spain.
   [Boada, L.; Moron-Nozaleda, G.; Parellada, M.] Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Pousa, E.; Gisbert, L.; Pamias, M.] Univ Autonoma Barcelona, Univ Hosp, Bellaterra 08193, Spain.
   [Mirapeix, I.; Marinas, L.] Univ Alcala De Henares, Dept Psychiat, Principe Asturias Univ Hosp, Madrid 28871, Spain.
RP Lahera, G (reprint author), Univ Alcala De Henares, Psychiat Med Special Dept, Fac Med, Campus Cient Tecnol, Madrid 28871, Spain.
EM guillermo.lahera@uah.es
CR Adachi T, 2004, BRAIN DEV-JPN, V26, P301, DOI 10.1016/S0387-7604(03)00170-0
   Adler N, 2010, PSYCHIAT RES, V178, P214, DOI 10.1016/j.psychres.2009.11.015
   APA, 2000, DIAGN STAT MAN MENT
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bauminger N, 1999, J AUTISM DEV DISORD, V29, P81, DOI 10.1023/A:1025974701090
   Beaumont RB, 2008, J AUTISM DEV DISORD, V38, P249, DOI 10.1007/s10803-007-0384-2
   Boada L., MOVIE ASSESSME UNPUB
   BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
   Corcoran Rhiannon, 2003, Cogn Neuropsychiatry, V8, P223, DOI 10.1080/13546800244000319
   Crane L, 2013, AUTISM, V17, P205, DOI 10.1177/1362361311418690
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Dennet D. C., 1987, BRAIN BEHAV SCI, V6, P343
   Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
   Ekman P., 1976, PICTURES FACIAL AFFE
   Fisher N, 2005, J CHILD PSYCHOL PSYC, V46, P409, DOI 10.1111/j.1469-7610.2004.00371.x
   Fombonne E, 2003, CHILD ADOL PSYCH CL, V12, P15, DOI 10.1016/S1056-4993(02)00050-0
   Fombonne E, 2001, J AUTISM DEV DISORD, V31, P363
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Gil D, 2012, REV PSIQUIATR SALUD, V5, P79, DOI 10.1016/j.rpsm.2011.11.004
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P215, DOI 10.1111/j.1469-7610.1994.tb01159.x
   Heavey L, 2000, J AUTISM DEV DISORD, V30, P225, DOI 10.1023/A:1005544518785
   Hermelin B., 1985, COMMUNICATION PROBLE
   Hosmer DW, 2000, APPL LOGISTIC REGRES, V2nd
   Instituto-Cervantes, 2012, ANN REPORT
   Jolliffe T, 1999, COGNITION, V71, P149, DOI 10.1016/S0010-0277(99)00022-0
   Kaland N, 2002, J CHILD PSYCHOL PSYC, V43, P517, DOI 10.1111/1469-7610.00042
   KERR SL, 1993, J ABNORM PSYCHOL, V102, P312, DOI 10.1037/0021-843X.102.2.312
   Lind SE, 2009, J AUTISM DEV DISORD, V39, P929, DOI 10.1007/s10803-009-0702-y
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   MCNEIL BJ, 1984, MED DECIS MAKING, V4, P137, DOI 10.1177/0272989X8400400203
   MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
   Montag C, 2011, PSYCHIAT RES, V186, P203, DOI 10.1016/j.psychres.2010.09.006
   Montag C, 2010, J AFFECT DISORDERS, V123, P264, DOI 10.1016/j.jad.2009.08.017
   Nunnally J. C., 1978, PSYCHOMETRIC THEORY
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
   Parellada M, 2013, EUR PSYCHIAT, V28, P102, DOI 10.1016/j.eurpsy.2011.06.004
   Pedersen A, 2012, PEDIATRICS, V129, pE629, DOI 10.1542/peds.2011-1145
   Perez-Sayes G., 2009, VERSION REVISADA TES
   PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7
   Perner J, 1989, Child Dev, V60, P688
   Phillips W, 1998, BRIT J DEV PSYCHOL, V16, P337
   Pinkham AE, 2014, SCHIZOPHRENIA BULL, V40, P813, DOI 10.1093/schbul/sbt081
   Pino O, 2008, SCHIZOPHR RES, V99, P139, DOI 10.1016/j.schres.2007.09.012
   Pousa E., 2002, MEASUREMENT THEORY M
   Preissler S, 2010, FRONT BEHAV NEUROSCI, V4, DOI 10.3389/fnbeh.2010.00182
   Purdon SE, 2005, SCREEN COGNITIVE IMP
   Rabin JS, 2012, NEUROIMAGE, V62, P520, DOI 10.1016/j.neuroimage.2012.05.002
   Ritter K, 2011, PSYCHIAT RES, V187, P241, DOI 10.1016/j.psychres.2010.09.013
   Riviere A., 1995, SIGLO CERO, V25, P17
   Rojo E, 2010, SCHIZOPHR RES, V116, P243, DOI 10.1016/j.schres.2009.08.005
   Rosenbaum RS, 2007, SCIENCE, V318, P1257, DOI 10.1126/science.1148763
   Rutherford MD, 2002, J AUTISM DEV DISORD, V32, P189, DOI 10.1023/A:1015497629971
   Schick B, 2007, CHILD DEV, V78, P376, DOI 10.1111/j.1467-8624.2007.01004.x
   Sharp C, 2011, J AM ACAD CHILD PSY, V50, P563, DOI 10.1016/j.jaac.2011.01.017
   Smeets T, 2009, HORM BEHAV, V55, P507, DOI 10.1016/j.yhbeh.2009.01.011
   Spreng RN, 2012, BRAIN RES, V1428, P43, DOI 10.1016/j.brainres.2010.12.024
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Swettenham J G, 1996, Cogn Neuropsychiatry, V1, P73, DOI 10.1080/135468096396712
   Tager-Flusberg H., 2000, LANGUAGE UNDERSTANDI, P24
   Trevarthen C., 1979, SPEECH BEGGINING INT
   Vellante M, 2013, COGN NEUROPSYCHIATRY, V18, P326, DOI 10.1080/13546805.2012.721728
   Wilbertz G, 2010, J AFFECT DISORDERS, V124, P262, DOI 10.1016/j.jad.2009.11.021
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
   Wolkenstein L, 2011, J AFFECT DISORDERS, V132, P104, DOI 10.1016/j.jad.2011.02.010
   Ziatas K, 1998, J CHILD PSYCHOL PSYC, V39, P755, DOI 10.1017/S0021963098002510
NR 67
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1886
EP 1896
DI 10.1007/s10803-014-2061-6
PG 11
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400008
PM 24522969
ER

PT J
AU Lanning, BA
   Baier, MEM
   Ivey-Hatz, J
   Krenek, N
   Tubbs, JD
AF Lanning, Beth A.
   Baier, Margaret E. Matyastik
   Ivey-Hatz, Julie
   Krenek, Nancy
   Tubbs, Jack D.
TI Effects of Equine Assisted Activities on Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Equine assisted activities and therapies; Quality of life;
   Therapeutic horseback riding
ID GENERIC CORE SCALES; SOCIAL-SKILLS; CHILDREN; METAANALYSIS; RELIABILITY;
   VALIDITY; INTERVENTIONS; PSYCHOTHERAPY
AB Quality of life assessments were used in this study to determine the behavioral changes of children diagnosed with autism spectrum disorder (ASD) who participated in equine assisted activities. Behavioral changes of children with ASD participating in 9 weeks of equines assisted activities (EAA) (N = 10) were compared to behavioral changes of children who participated in a non-equine intervention (N = 8). Parents noted significant improvements in their child's physical, emotional and social functioning following the first 6 weeks of EAA. The children participating in the non-equine program also demonstrated improvement in behavior, but to a lesser degree. The favorable outcome of this study lends support for continuation of programs utilizing EAA in the treatment of children with ASD.
C1 [Lanning, Beth A.] Baylor Univ, Hlth Human Performance & Recreat Dept, Waco, TX 76798 USA.
   [Baier, Margaret E. Matyastik] Baylor Univ, Dept Family & Consumer Sci, Waco, TX 76798 USA.
   [Ivey-Hatz, Julie] Baylor Univ, Waco, TX 76798 USA.
   [Krenek, Nancy] ROCK, Georgetown, TX USA.
   [Tubbs, Jack D.] Baylor Univ, Dept Stat Sci, Waco, TX 76798 USA.
RP Lanning, BA (reprint author), Baylor Univ, Hlth Human Performance & Recreat Dept, One Bear Pl, Waco, TX 76798 USA.
EM Beth_Lanning@baylor.edu
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
   Bass M, 2009, J AUTISM DEV DISORD, V39, P1261, DOI 10.1007/s10803-009-0734-3
   Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
   Burch M. R., 1995, VOLUNTEERING WITH YO
   Case-Smith J, 2008, AM J OCCUP THER, V62, P416
   Dingman A., 2008, ENCOUNTER EDUCATION, V21, P11
   Dunn W., 2002, FOCUS AUTISM OTHER D, V17, P172, DOI 10.1177/10883576020170030701
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Gabriels RL, 2012, RES AUTISM SPECT DIS, V6, P578, DOI 10.1016/j.rasd.2011.09.007
   Kern JK, 2011, ALTERN THER HEALTH M, V17, P14
   Laushey KM, 2000, J AUTISM DEV DISORD, V30, P183, DOI 10.1023/A:1005558101038
   Limbers CA, 2009, J AUTISM DEV DISORD, V39, P1529, DOI 10.1007/s10803-009-0777-5
   Limbers CA, 2011, VALUE HEALTH, V14, P521, DOI 10.1016/j.jval.2010.10.031
   Murray E. A., 2002, SENSORY INTEGRATION, P71
   Nuner J. E., 2012, DIMENSIONS, V39, P20
   Professional Association of Therapeutic Horsemanship International, 2014, EAAT DEFINITIONS
   Raat H, 2005, J EPIDEMIOL COMMUN H, V59, P75, DOI 10.1136/jech.2003.012614
   Riede M. R., 1988, PHYSIOTHERAPY ON THE
   Rothe EQ, 2005, INT J CLIN HLTH PSYC, V5, P373
   Schmidt R. A., 2005, MOTOR COMPARISON AND
   Schultz PN, 2007, HEALTH SOC CARE COMM, V15, P265, DOI 10.1111/j.1365-2524.2006.00684.x
   Valenti M., 2010, CHILD ADOL PSYCH CL, V4, P1
   Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006
   Ward SC, 2013, J AUTISM DEV DISORD, V43, P2190, DOI 10.1007/s10803-013-1773-3
   Ware J. E, 2008, THE CHQ USERS MANUAL
   Wuang YP, 2010, ADAPT PHYS ACT Q, V27, P113
   Zadnikar M, 2011, DEV MED CHILD NEUROL, V53, P684, DOI 10.1111/j.1469-8749.2011.03951.x
NR 27
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1897
EP 1907
DI 10.1007/s10803-014-2062-5
PG 11
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400009
PM 24526337
ER

PT J
AU Zaidman-Zait, A
   Mirenda, P
   Duku, E
   Szatmari, P
   Georgiades, S
   Volden, J
   Zwaigenbaum, L
   Vaillancourt, T
   Bryson, S
   Smith, I
   Fombonne, E
   Roberts, W
   Waddell, C
   Thompson, A
AF Zaidman-Zait, Anat
   Mirenda, Pat
   Duku, Eric
   Szatmari, Peter
   Georgiades, Stelios
   Volden, Joanne
   Zwaigenbaum, Lonnie
   Vaillancourt, Tracy
   Bryson, Susan
   Smith, Isabel
   Fombonne, Eric
   Roberts, Wendy
   Waddell, Charlotte
   Thompson, Ann
CA Pathways ASD Study Team
TI Examination of Bidirectional Relationships Between Parent Stress and Two
   Types of Problem Behavior in Children with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Parenting stress; Externalizing behavior;
   Internalizing behavior
ID INDEX-SHORT FORM; STONES TRIPLE-P; MATERNAL DEPRESSION; DEVELOPMENTAL
   DELAY; PRESCHOOL-CHILDREN; YOUNG-CHILDREN; INTERVENTION; MOTHERS;
   IMPACT; DISABILITIES
AB Path analysis within a structural equation modeling framework was employed to examine the relationships between two types of parent stress and children's externalizing and internalizing behaviors over a 4-year period, in a sample of 184 mothers of young children with autism spectrum disorder. Parent stress was measured with the Parenting Stress Index-Short Form and child behavior was measured with Child Behavior Checklist/1.5-5. Across all time points, parent general distress predicted both types of child behaviors, but not vice versa. In addition, there was modest evidence of a bidirectional relationship between parenting distress and both types of child behaviors from 12 months post-diagnosis to age 6. Results are compared to previous work in this area, with implications for early intervention.
C1 [Zaidman-Zait, Anat; Mirenda, Pat] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
   [Duku, Eric; Georgiades, Stelios; Thompson, Ann] McMaster Univ, Hamilton, ON, Canada.
   [Szatmari, Peter] McMaster Univ, Offord Ctr Child Studies, Hamilton, ON, Canada.
   [Volden, Joanne; Zwaigenbaum, Lonnie] Univ Alberta, Edmonton, AB, Canada.
   [Vaillancourt, Tracy] Univ Ottawa, Ottawa, ON, Canada.
   [Bryson, Susan; Smith, Isabel] Dalhousie Univ, IWK Hlth Sci Ctr, Halifax, NS, Canada.
   [Fombonne, Eric] McGill Univ, Montreal, PQ, Canada.
   [Roberts, Wendy] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Waddell, Charlotte] Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada.
RP Zaidman-Zait, A (reprint author), Tel Aviv Univ, Sch Educ, POB 39040, IL-6997801 Tel Aviv, Israel.
EM anatzaidman@post.tau.ac.il
RI Vaillancourt, Tracy/F-8949-2015
CR Abidin RR, 1995, PARENTING STRESS IND
   Achenbach T. M., 2000, MANUAL FOR ASEBA PRE
   American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
   Baker BL, 2003, J INTELL DISABIL RES, V47, P217, DOI 10.1046/j.1365-2788.2003.00484.x
   Baker JK, 2011, J ABNORM PSYCHOL, V120, P465, DOI 10.1037/a0021900
   Bauminger N, 2010, AUTISM RES, V3, P101, DOI 10.1002/aur.131
   Bennett T, 2012, J CHILD PSYCHOL PSYC, V53, P89, DOI 10.1111/j.1469-7610.2011.02451.x
   Brown T. A., 2006, CONFIRMATORY FACTOR
   Bryan A, 2007, AIDS BEHAV, V11, P365, DOI 10.1007/s10461-006-9150-2
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Crnic KA, 2005, INFANT CHILD DEV, V14, P117, DOI 10.1002/icd.384
   Deater-Deckard K, 1998, CLIN PSYCHOL-SCI PR, V5, P314
   Derogatis L, 1994, SCL 90 R ADMINISTRAT, V3rd
   Durand V. M., 2011, OPTIMISTIC PARENTING
   Durand VM, 2013, J POSIT BEHAV INTERV, V15, P133, DOI 10.1177/1098300712458324
   Embry L, 2002, MON PARENT, P203
   Estes A, 2013, BRAIN DEV-JPN, V35, P133, DOI 10.1016/j.braindev.2012.10.004
   Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
   Gelfand D. M., 2000, CHILD STUDY J, V30, P153
   Goodman SH, 2011, CLIN CHILD FAM PSYCH, V14, P1, DOI 10.1007/s10567-010-0080-1
   Hall Heather R, 2012, Issues Compr Pediatr Nurs, V35, P194, DOI 10.3109/01460862.2012.734210
   Haskett ME, 2006, J CLIN CHILD ADOLESC, V35, P302, DOI 10.1207/s15374424jccp3502_14
   Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
   Hastings RP, 2006, AM J MENT RETARD, V111, P48, DOI 10.1352/0895-8017(2006)111[48:MDAEEC]2.0.CO;2
   Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
   Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
   Hoffman C, 2006, PARENT-SCI PRACT, V6, P271, DOI 10.1207/s15327922par0604_1
   Holmbeck GN, 1997, J CONSULT CLIN PSYCH, V65, P599, DOI 10.1037/0022-006X.65.4.599
   Hoyle R. H., 1995, STRUCTURAL EQUATION
   Karst JS, 2012, CLIN CHILD FAM PSYCH, V15, P247, DOI 10.1007/s10567-012-0119-6
   Kline R. B., 2011, PRINCIPLES AND PRACT
   Kuhn JC, 2006, AM J ORTHOPSYCHIAT, V76, P564, DOI 10.1037/0002-9432.76.4.564
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lord C., 2002, THE AUTISM DIAGNOSTI
   Lucyshyn J., 2002, FAMILIES AND POSITIV
   Lucyshyn J., 2011, HANDBOOK OF POSITIVE, P73
   Lucyshyn JM, 2004, RES PRACT PERS SEV D, V29, P104, DOI 10.2511/rpsd.29.2.104
   MacLeod K., 2012, ABSTRACTS OF THE INT, P312
   McStay RL, 2014, AUTISM, V18, P502, DOI 10.1177/1362361313485163
   Muthen L. K, 2012, MPLUS USERS GUIDE
   Orsmond GI, 2003, AM J MENT RETARD, V108, P257, DOI 10.1352/0895-8017(2003)108<257:BPIAWM>2.0.CO;2
   Osborne LA, 2010, RES AUTISM SPECT DIS, V4, P405, DOI 10.1016/j.rasd.2009.10.011
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Pandolfi V, 2009, J AUTISM DEV DISORD, V39, P986, DOI 10.1007/s10803-009-0716-5
   Reed P., 2010, EXCEPT CHILDREN, V76, P54
   Roid G. H., 2004, MERRILL PALMER REVIS
   Rutter M., 2003, THE AUTISM DIAGNOSTI
   Sanders MR, 2004, J INTELLECT DEV DIS, V29, P265, DOI 10.1080/13668250412331285127
   Shine R, 2010, J DEV DISABILITIES, V16, P64
   Silva LMT, 2012, J AUTISM DEV DISORD, V42, P566, DOI 10.1007/s10803-011-1274-1
   Smith I. M., 2013, SPAIN PAPER PRESENTE
   Smith IM, 2010, AJIDD-AM J INTELLECT, V115, P504, DOI [10.1352/1944-7558-115.6.504, 10.1352/194475581156504]
   Solish A, 2008, RES AUTISM SPECT DIS, V2, P728, DOI 10.1016/j.rasd.2008.03.001
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Steiner AM, 2012, J AUTISM DEV DISORD, V42, P1218, DOI 10.1007/s10803-011-1194-0
   Stock R, 2013, RES AUTISM SPECT DIS, V7, P1168, DOI 10.1016/j.rasd.2013.06.002
   Strauss K, 2012, RES DEV DISABIL, V33, P688, DOI 10.1016/j.ridd.2011.11.008
   Theule J, 2011, J CHILD FAM STUD, V20, P640, DOI 10.1007/s10826-010-9439-7
   Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
   Westland JC, 2010, ELECTRON COMMER R A, V9, P476, DOI 10.1016/j.elerap.2010.07.003
   Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
   Zaidman-Zait A, 2011, AUTISM RES, V4, P336, DOI 10.1002/aur.213
   Zaidman-Zait A, 2010, J CHILD PSYCHOL PSYC, V51, P1269, DOI 10.1111/j.1469-7610.2010.02266.x
   Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 64
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1908
EP 1917
DI 10.1007/s10803-014-2064-3
PG 10
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400010
PM 24550079
ER

PT J
AU Kulage, KM
   Smaldone, AM
   Cohn, EG
AF Kulage, Kristine M.
   Smaldone, Arlene M.
   Cohn, Elizabeth G.
TI How Will DSM-5 Affect Autism Diagnosis? A Systematic Literature Review
   and Meta-analysis
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE DSM-5; Autism spectrum disorder; PDD-NOS; Diagnosis; Public health
   policy
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; IV-TR; PROPOSED
   DSM-5; CHILDREN; CRITERIA; IDENTIFICATION; SPECIFICITY; SENSITIVITY;
   TODDLERS
AB We conducted a systematic review and meta-analysis to determine the effect of changes to the Diagnostic and Statistical Manual (DSM)-5 on autism spectrum disorder (ASD) and explore policy implications. We identified 418 studies; 14 met inclusion criteria. Studies consistently reported decreases in ASD diagnosis (range 7.3-68.4 %) using DSM-5 criteria. There were statistically significant pooled decreases in ASD [31 % (20-44), p = 0.006] and DSM-IV-TR subgroups of Autistic disorder [22 % (16-29), p < 0.001] and pervasive developmental disorder-not otherwise specified (PDD-NOS) [70 % (55-82), p = 0.01]; however, Asperger's disorder pooled decrease was not significant [70 % (26-94), p = 0.38]. DSM-5 will likely decrease the number of individuals diagnosed with ASD, particularly the PDD-NOS subgroup. Research is needed on policies regarding services for individuals lacking diagnosis but requiring assistance.
C1 [Kulage, Kristine M.] Columbia Univ, Dept Hlth Policy & Management, Mailman Sch Publ Hlth, New York, NY 10032 USA.
   [Kulage, Kristine M.] Columbia Univ, Off Scholarship & Res Dev, Sch Nursing, New York, NY 10032 USA.
   [Smaldone, Arlene M.; Cohn, Elizabeth G.] Columbia Univ, Sch Nursing, New York, NY 10032 USA.
RP Kulage, KM (reprint author), Columbia Univ, Off Scholarship & Res Dev, Sch Nursing, 630 West 168th St,Box 6, New York, NY 10032 USA.
EM kk729@columbia.edu
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
   APA, 2012, DSM 5 AUT SPECTR DIS
   APA, 2013, SOC PRAGM COMM DIS
   APA, 2012, REC UPD PROP REV DSM
   Autism Speaks, 2013, CT LEG PASS DSM V BI
   Barton ML, 2013, J AUTISM DEV DISORD, V43, P1184, DOI 10.1007/s10803-013-1817-8
   Beighley JS, 2013, DEV NEUROREHABIL, V16, P375, DOI 10.3109/17518423.2012.760119
   Falkmer T, 2013, EUR CHILD ADOLES PSY, V22, P329, DOI 10.1007/s00787-013-0375-0
   Gibbs V, 2012, J AUTISM DEV DISORD, V42, P1750, DOI 10.1007/s10803-012-1560-6
   Glasson EJ, 2008, MED J AUSTRALIA, V188, P288
   Greaves-Lord K, 2013, J AUTISM DEV DISORD, V43, P1784, DOI 10.1007/s10803-012-1724-4
   Hemp R, 2002, MENT RETARD, V40, P418, DOI 10.1352/0047-6765(2002)040<0418:STIPSF>2.0.CO;2
   Hu VW, 2012, DIS MARKERS, V33, P277, DOI 10.3233/DMA-2012-0916
   Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
   Lane C., 2013, PSYCHOL TODAY
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lucas NP, 2010, J CLIN EPIDEMIOL, V63, P854, DOI 10.1016/j.jclinepi.2009.10.002
   Mark TL, 2003, PSYCHIAT SERV, V54, P188, DOI 10.1176/appi.ps.54.2.188
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P75, DOI 10.1016/j.rasd.2007.03.002
   Matson JL, 2012, RES AUTISM SPECT DIS, V6, P19, DOI 10.1016/j.rasd.2011.08.003
   Matson JL, 2012, J DEV PHYS DISABIL, V24, P403, DOI 10.1007/s10882-012-9278-0
   Matson JL, 2012, DEV NEUROREHABIL, V15, P185, DOI 10.3109/17518423.2012.672341
   Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
   Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P298, DOI 10.1016/j.rasd.2012.08.011
   Mazefsky CA, 2013, J AUTISM DEV DISORD, V43, P1236, DOI 10.1007/s10803-012-1665-y
   McClure I, 2010, AUTISM, V14, P589, DOI 10.1177/1362361310373369
   McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
   Moher D, 2009, ANN INTERN MED, V151, P264
   Montes Guillermo, 2009, Pediatrics, V124 Suppl 4, pS407, DOI 10.1542/peds.2009-1255L
   National Conference of State Legislatures, 2012, INS COV AUT
   Neal D, 2012, DEV NEUROREHABIL, V15, P329, DOI 10.3109/17518423.2012.697492
   Newschaffer CJ, 2003, PUBLIC HEALTH REP, V118, P393, DOI 10.1016/S0033-3549(04)50270-4
   Peterson Kathleen, 2013, Nursing, V43, P28, DOI 10.1097/01.NURSE.0000427987.16317.ae
   Regier DA, 2013, AM J PSYCHIAT, V170, P59, DOI 10.1176/appi.ajp.2012.12070999
   Robertson K, 2013, J PAEDIATR CHILD H, V49, P1057, DOI 10.1111/jpc.12303
   Robison J. E., 2013, PSYCHOL TODAY
   Rossi J, 2013, KENNEDY INST ETHIC J, V23, P105
   Ruble LA, 2005, J AUTISM DEV DISORD, V35, P3, DOI 10.1007/s10803-004-1026-6
   Rutter M., 2002, AUTISM DIAGNOSTIC IN
   Taheri A, 2012, J AUTISM DEV DISORD, V42, P1810, DOI 10.1007/s10803-012-1599-4
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Wilson CE, 2013, J AUTISM DEV DISORD, V43, P2515, DOI 10.1007/s10803-013-1799-6
   Woolfenden S, 2012, RES AUTISM SPECT DIS, V6, P345, DOI 10.1016/j.rasd.2011.06.008
   Worley JA, 2012, RES AUTISM SPECT DIS, V6, P965, DOI 10.1016/j.rasd.2011.12.012
   You Y., 2011, N AM J MED SCI, V4, P116
NR 47
TC 5
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1918
EP 1932
DI 10.1007/s10803-014-2065-2
PG 15
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400011
PM 24531932
ER

PT J
AU Hoefman, R
   Payakachat, N
   van Exel, J
   Kuhlthau, K
   Kovacs, E
   Pyne, J
   Tilford, JM
AF Hoefman, Renske
   Payakachat, Nalin
   van Exel, Job
   Kuhlthau, Karen
   Kovacs, Erica
   Pyne, Jeffrey
   Tilford, J. Mick
TI Caring for a Child with Autism Spectrum Disorder and Parents' Quality of
   Life: Application of the CarerQol
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Family caregiving; Subjective burden; Autism spectrum disorders (ASDs);
   Quality of life; CarerQol; Construct validation
ID INFORMAL CARE; CAREGIVER BURDEN; STRESS PROLIFERATION; ECONOMIC
   EVALUATIONS; DEPRESSED MOOD; MENTAL-HEALTH; IMPACT; FAMILY; ASD;
   INSTRUMENT
AB This study describes the impact of caregiving on parents of children with autism spectrum disorders (ASDs). Secondly, we investigate construct validation of the care-related quality of life instrument (CarerQol) measuring impact of caregiving. Primary caregivers of children with ASDs were included. Many parents experienced considerable problems combining daily activities with care, had financial problems or suffered from depressive mood. Validity tests showed that a higher impact of caring on the CarerQol was positively associated with higher subjective burden and lower family quality of life. Most of the associations between CarerQol scores and background characteristics confirmed previous research. The CarerQol validly measures the impact of caregiving for children with ASDs on caregivers in our sample. The CarerQol may therefore be useful for including parent outcomes in research on ASDs.
C1 [Hoefman, Renske; van Exel, Job] Erasmus Univ, Inst Hlth Policy & Management, NL-3000 DR Rotterdam, Netherlands.
   [Payakachat, Nalin] Univ Arkansas Med Sci, Div Pharmaceut Evaluat & Policy, Little Rock, AR 72205 USA.
   [Kuhlthau, Karen] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
   [Kuhlthau, Karen] Massachusetts Gen Hosp, Ctr Child & Adolescent Hlth Policy, Boston, MA 02114 USA.
   [Kovacs, Erica] Columbia Univ, Dept Psychiat, Div Child & Adolescent Psychiat, Med Ctr, New York, NY USA.
   [Pyne, Jeffrey] Cent Arkansas Vet Healthcare Syst, Ctr Mental Hlth Outcomes Res, Little Rock, AR USA.
   [Tilford, J. Mick] Univ Arkansas Med Sci, Dept Hlth Policy & Management, Little Rock, AR 72205 USA.
RP Hoefman, R (reprint author), Erasmus Univ, Inst Hlth Policy & Management, POB 1738, NL-3000 DR Rotterdam, Netherlands.
EM hoefman@bmg.eur.nl
CR Al-Janabi H, 2008, SOC SCI MED, V67, P111, DOI 10.1016/j.socscimed.2008.03.032
   Aman Michael G, 2004, Semin Pediatr Neurol, V11, P225, DOI 10.1016/j.spen.2004.07.006
   Andren S, 2005, SCAND J CARING SCI, V19, P157, DOI 10.1111/j.1471-6712.2005.00328.x
   Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
   Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
   Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
   Bobinac A, 2010, J HEALTH ECON, V29, P549, DOI 10.1016/j.jhealeco.2010.05.003
   Brannan AM, 1997, J EMOT BEHAV DISORD, V5, P212
   Brazier JE, 2004, MED CARE, V42, P851, DOI 10.1097/01.mlr.0000135827.18610.0d
   Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
   Brouwer W, 2010, EC EVALUATION CHILD
   Brouwer W. B. F., 2011, IVICQ IMTA VAL INF C
   Brouwer W. B. F., 2011, QUAL LIFE RES, V20, P1485
   Brouwer WBF, 2006, QUAL LIFE RES, V15, P1005, DOI 10.1007/s11136-005-5994-6
   Brouwer WBF, 2005, HEALTH POLICY, V74, P85, DOI 10.1016/j.healthpol.2004.12.008
   Couturier JL, 2005, J AM ACAD CHILD PSY, V44, P815, DOI 10.1097/01.chi.0000166377.22651.87
   Deeken JF, 2003, J PAIN SYMPTOM MANAG, V26, P922, DOI 10.1016/S0885-3924(03)00327-0
   EuroQol Group, 1990, HLTH POLICY, V16, P199, DOI DOI 10.1016/0168-8510(90)90421-9
   Feeny D, 2002, MED CARE, V40, P113, DOI 10.1097/00005650-200202000-00006
   FELCE D, 1995, RES DEV DISABIL, V16, P51, DOI 10.1016/0891-4222(94)00028-8
   Giallo R, 2013, AUTISM, V17, P465, DOI 10.1177/1362361311416830
   Gurney JG, 2006, ARCH PEDIAT ADOL MED, V160, P825, DOI 10.1001/archpedi.160.8.825
   Hamlyn-Wright S, 2007, AUTISM, V11, P489, DOI 10.1177/1362361307083258
   Hoefman RJ, 2014, MED DECIS MAKING, V34, P84, DOI 10.1177/0272989X13492013
   Hoefman RJ, 2011, AGING MENT HEALTH, V15, P1018, DOI 10.1080/13607863.2011.575351
   Hoefman RJ, 2011, QUAL LIFE RES, V20, P875, DOI 10.1007/s11136-010-9829-8
   Hoefman RJ, 2013, PHARMACOECONOMICS, V31, P1105, DOI 10.1007/s40273-013-0104-z
   Hoffman L, 2006, J MARRIAGE FAM, V68, P1069, DOI 10.1111/j.1741-3737.2006.00314.x
   Hopkins WA, 2002, NEW VIEW STAT EFFECT
   Karst JS, 2012, CLIN CHILD FAM PSYCH, V15, P247, DOI 10.1007/s10567-012-0119-6
   Khanna R, 2011, J AUTISM DEV DISORD, V41, P1214, DOI 10.1007/s10803-010-1140-6
   Kuhlthau K, 2013, RES AUTISM SPECT DIS, V7, P1035, DOI 10.1016/j.rasd.2013.04.006
   Kuhlthau K, 2010, MATERN CHILD HLTH J, V14, P155, DOI 10.1007/s10995-008-0434-1
   Kuhlthau K, 2005, MATERN CHILD HLTH J, V9, P207, DOI 10.1007/s10995-005-4870-x
   Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2
   Kuo DZ, 2011, ARCH PEDIAT ADOL MED, V165, P1020, DOI 10.1001/archpediatrics.2011.172
   Marks NF, 2002, J MARRIAGE FAM, V64, P657, DOI 10.1111/j.1741-3737.2002.00657.x
   McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
   Myers BJ, 2009, RES AUTISM SPECT DIS, V3, P670, DOI 10.1016/j.rasd.2009.01.004
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Pogany L, 2006, QUAL LIFE RES, V15, P143, DOI 10.1007/s11136-005-0198-7
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   ROBINSON BC, 1983, J GERONTOL, V38, P344
   Sawyer MG, 2010, J AUTISM DEV DISORD, V40, P620, DOI 10.1007/s10803-009-0912-3
   Seiber W. J., 2008, QUALITY WELL BEING S
   Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
   Smith LE, 2008, J AUTISM DEV DISORD, V38, P876, DOI 10.1007/s10803-007-0461-6
   Streiner D, 2003, HLTH MEASUREMENT SCA
   Strock M., 2007, AUTISM SPECTRUM DISO
   Stuart M, 2009, RES AUTISM SPECT DIS, V3, P86, DOI 10.1016/j.rasd.2008.04.006
   Tolkacheva N, 2011, AGEING SOC, V31, P34, DOI 10.1017/S0144686X10000711
   Hoefman RJ, 2013, HEALTH QUAL LIFE OUT, V11, DOI 10.1186/1477-7525-11-173
   van Campen C, 2013, SCAND J CARING SCI, V27, P44, DOI 10.1111/j.1471-6712.2012.00998.x
   Van Durme T, 2012, INT J NURS STUD, V49, P490, DOI 10.1016/j.ijnurstu.2011.10.011
   van Exel NJA, 2004, CLIN REHABIL, V18, P683, DOI 10.1191/0269215504cr743oa
   van Exel NJA, 2004, CLIN REHABIL, V18, P203, DOI 10.1191/0269215504cr723oa
   ZARIT SH, 1980, GERONTOLOGIST, V20, P649
NR 57
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1933
EP 1945
DI 10.1007/s10803-014-2066-1
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400012
PM 24577786
ER

PT J
AU Medeiros, K
   Winsler, A
AF Medeiros, Kristen
   Winsler, Adam
TI Parent-Child Gesture Use During Problem Solving in Autistic Spectrum
   Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Gesture; Receptive communication; Parent-child
   interaction
ID JOINT ATTENTION; YOUNG-CHILDREN; COMMUNICATION DEVELOPMENT;
   NONVERBAL-COMMUNICATION; LANGUAGE-DEVELOPMENT; PRESCHOOL-CHILDREN;
   INFANT INTERACTION; INTERVENTION; SKILLS; BEHAVIORS
AB This study examined the relationship between child language skills and parent and child gestures of 58 youths with and without an autism spectrum disorder (ASD) diagnosis. Frequencies and rates of total gesture use as well as five categories of gestures (deictic, conventional, beat, iconic, and metaphoric) were reliably coded during the collaborative Tower of Hanoi task. Children with ASD had lower Peabody Picture Vocabulary Test scores and gestured less and at lower rates compared to typically developing children. Gesture use was unrelated to vocabulary for typically developing children, but positively associated with vocabulary for those with ASD. Demographic correlates of gesturing differed by group. Gesture may be a point of communication intervention for families with children with ASD.
C1 [Medeiros, Kristen] SUNY Coll New Paltz, New Paltz, NY 12561 USA.
   [Winsler, Adam] George Mason Univ, Dept Psychol 3F5, Fairfax, VA 22030 USA.
RP Medeiros, K (reprint author), SUNY Coll New Paltz, 600 Hawk Dr,JFT 306, New Paltz, NY 12561 USA.
EM medeirok@newpaltz.edu; awinsler@gmu.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Bell NL, 2001, J CLIN PSYCHOL, V57, P417, DOI 10.1002/jclp.1024
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Campbell JM, 2001, ASSESSMENT, V8, P85, DOI 10.1177/107319110100800108
   Capone NC, 2004, J SPEECH LANG HEAR R, V47, P173, DOI [10.1044/1092-4388(2004/015), 10.1044/1092-4388(2004/15)]
   Carbone VJ, 2010, J APPL BEHAV ANAL, V43, P705, DOI 10.1901/jaba.2010.43-705
   Cartmill EA, 2013, P NATL ACAD SCI USA, V110, P11278, DOI 10.1073/pnas.1309518110
   Cihak DF, 2010, RES AUTISM SPECT DIS, V4, P763, DOI 10.1016/j.rasd.2010.01.017
   de Marchena A, 2010, AUTISM RES, V3, P311, DOI 10.1002/aur.159
   Demir OE, 2014, DEV PSYCHOL, V50, P815, DOI 10.1037/a0034322
   Doussard-Roosevelt JA, 2003, DEV PSYCHOPATHOL, V15, P277, DOI 10.1017/S0954579403000154
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   Eikeseth S, 2012, RES AUTISM SPECT DIS, V6, P829, DOI 10.1016/j.rasd.2011.09.002
   El-Ghoroury NH, 1999, J AUTISM DEV DISORD, V29, P249, DOI 10.1023/A:1023036223397
   Evans GW, 1999, DEV PSYCHOL, V35, P1020, DOI 10.1037/0012-1649.35.4.1020
   Freeth M, 2010, J EXP CHILD PSYCHOL, V105, P20, DOI 10.1016/j.jecp.2009.10.001
   Ganz J. B., 2007, EXCEPTIONALITY, V15, P249, DOI 10.1080/09362830701655816
   Ganz JB, 2012, RES DEV DISABIL, V33, P406, DOI 10.1016/j.ridd.2011.09.023
   Garber P, 2002, COGNITIVE SCI, V26, P817
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Goldin-Meadow S, 2009, CHILD DEV PERSPECT, V3, P106
   Goldin-Meadow S, 2009, CAMB HB LANG LINGUIS, P145
   Grimminger A, 2010, GESTURE, V10, P251, DOI 10.1075/gest.10.2.-3.07gri
   GUTMANN AJ, 1979, DEV PSYCHOL, V15, P197, DOI 10.1037/0012-1649.15.2.197
   Ham HS, 2010, CORTEX, V46, P407, DOI 10.1016/j.cortex.2009.06.005
   Ham HS, 2011, J AUTISM DEV DISORD, V41, P1, DOI 10.1007/s10803-010-1011-1
   HART B, 1992, DEV PSYCHOL, V28, P1096, DOI 10.1037/0012-1649.28.6.1096
   Hudry K, 2010, INT J LANG COMM DIS, V45, P681, DOI 10.3109/13682820903461493
   Ibanez LV, 2013, INFANCY, V18, P687, DOI 10.1111/j.1532-7078.2012.00142.x
   Iverson J. M., 2010, ENFANCE, V62, P257, DOI [10.4074/S0013754510003046, DOI 10.4074/S0013754510003046]
   Iverson J. M., 2005, PSYCHOL SCI, V16, P368, DOI DOI 10.1111/J.0956-7976.2005.01542.X
   Iverson JM, 2011, J SPEECH LANG HEAR R, V54, P72, DOI 10.1044/1092-4388(2010/08-0197)
   Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
   Kelly S. D., 2008, LANGUAGE LINGUISTICS, V2, P569, DOI [10.1111/j.1749-818X.2008.00067.x, DOI 10.1111/J.1749-818X.2008.00067.X]
   Kikuchi Y, 2009, CHILD DEV, V80, P1421, DOI 10.1111/j.1467-8624.2009.01342.x
   Kjellmer L, 2012, RES DEV DISABIL, V33, P172, DOI 10.1016/j.ridd.2011.09.003
   Kurt O, 2011, KURAM UYGUL EGIT BIL, V11, P1436
   Landa R, 2007, MENT RETARD DEV D R, V13, P16, DOI 10.1002/mrdd.20134
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
   Leaper C, 1998, DEV PSYCHOL, V34, P3, DOI 10.1037//0012-1649.34.1.3
   LEMANEK KL, 1993, J CLIN CHILD PSYCHOL, V22, P68, DOI 10.1207/s15374424jccp2201_7
   LOVELAND KA, 1986, J AUTISM DEV DISORD, V16, P335, DOI 10.1007/BF01531663
   Mayberry RI, 2000, CURR DIR PSYCHOL SCI, V9, P192, DOI 10.1111/1467-8721.00092
   MCHALE SM, 1980, J AUTISM DEV DISORD, V10, P299, DOI 10.1007/BF02408289
   Miniscalco C, 2012, RES AUTISM SPECT DIS, V6, P204, DOI 10.1016/j.rasd.2011.05.001
   Mitchell S., 2006, J DEV BEHAV PEDIATR, V27, P69, DOI DOI 10.1097/00004703-200604002-00004
   Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437
   Namy LL, 2002, J CHILD LANG, V29, P911, DOI 10.1017/S0305000902005305
   Ozcaliskan S, 2014, APPL PSYCHOLINGUIST, V35, P1143, DOI 10.1017/S0142716412000720
   Peters T., 1999, AUTISM MED ED ASPECT
   Presmanes AG, 2007, J AUTISM DEV DISORD, V37, P133, DOI 10.1007/s10803-006-0338-0
   Riby DM, 2012, DEVELOPMENTAL SCI, V15, P281, DOI 10.1111/j.1467-7687.2011.01125.x
   Roth WM, 2002, LEARN INSTR, V12, P285, DOI 10.1016/S0959-4752(01)00023-8
   Rozga A, 2011, J AUTISM DEV DISORD, V41, P287, DOI 10.1007/s10803-010-1051-6
   Saint-Georges C., 2011, PLOS ONE, V6, P1
   Schertz HH, 2013, EARLY CHILD RES Q, V28, P249, DOI 10.1016/j.ecresq.2012.06.006
   Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155
   Smith IM, 2007, COGN NEUROPSYCHOL, V24, P679, DOI 10.1080/02643290701669703
   Sowden H, 2008, CLIN LINGUIST PHONET, V22, P804, DOI 10.1080/02699200801919745
   STONE WL, 1990, J AUTISM DEV DISORD, V20, P437, DOI 10.1007/BF02216051
   Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091
   Tincani M, 2011, REM SPEC EDUC, V32, P458, DOI 10.1177/0741932510362494
   Valentino Amber L, 2011, Anal Verbal Behav, V27, P95
   Walton KM, 2013, RES AUTISM SPECT DIS, V7, P687, DOI 10.1016/j.rasd.2013.02.012
   Wan MW, 2012, RES DEV DISABIL, V33, P924, DOI 10.1016/j.ridd.2011.12.011
   Watson LR, 2013, AM J SPEECH-LANG PAT, V22, P25, DOI 10.1044/1058-0360(2012/11-0145)
   WELSH MC, 1991, DEV NEUROPSYCHOL, V7, P131
   Wetherby AM, 1998, AM J SPEECH-LANG PAT, V7, P79
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Winsler A, 2007, J AUTISM DEV DISORD, V37, P1617, DOI 10.1007/s10803-006-0294-8
   Wong CS, 2013, AUTISM, V17, P340, DOI 10.1177/1362361312474723
   Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x
   Yoder P, 2009, J AUTISM DEV DISORD, V39, P1381, DOI 10.1007/s10803-009-0753-0
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 77
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1946
EP 1958
DI 10.1007/s10803-014-2069-y
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400013
PM 24535577
ER

PT J
AU van den Bergh, SFWM
   Scheeren, AM
   Begeer, S
   Koot, HM
   Geurts, HM
AF van den Bergh, Sanne F. W. M.
   Scheeren, Anke M.
   Begeer, Sander
   Koot, Hans M.
   Geurts, Hilde M.
TI Age Related Differences of Executive Functioning Problems in Everyday
   Life of Children and Adolescents in the Autism Spectrum
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Autism severity; Behavioral Rating Inventory Executive Functions
   (BRIEF); Development; Executive functioning
ID BEHAVIOR RATING INVENTORY; LATENT-VARIABLE ANALYSIS; SPATIAL
   WORKING-MEMORY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT
   HYPERACTIVITY DISORDER; MULTIPLE CASE SERIES; DEVELOPMENTAL DISORDERS;
   CENTRAL COHERENCE; LATE CHILDHOOD; REAL-WORLD
AB Numerous studies investigated executive functioning (EF) problems in people with autism spectrum disorders (ASD) using laboratory EF tasks. As laboratory task performances often differ from real life observations, the current study focused on EF in everyday life of 118 children and adolescents with ASD (6-18 years). We investigated age-related and individual differences in EF problems as reported by parents on the Behavioral Rating Inventory Executive Functions (BRIEF: Gioia et al. in Behavior rating inventory of executive function. Psychological Assessment Resources, Odesse 2000), and examined the association with autism severity. Inhibition problems were mostly found in the youngest group (6- to 8-year-olds), whereas problems with planning where more evident for 12- to 14-year-olds as compared to 9- to 11-year-olds. In a subsample of participants meeting the ADOS ASD cut-off criteria the age related differences in planning were absent, while problems with cognitive flexibility were less apparent in 15- to 18-year-olds, compared to 9- to 11-, and 12- to 14-year olds. EF problems surpassing the clinical cutoff were only observed in 20 % (planning) to 51 % (cognitive flexibility) of the children and adolescents, and no relation was found with ASD symptom severity. This underlines the heterogeneous nature of ASD.
C1 [van den Bergh, Sanne F. W. M.; Geurts, Hilde M.] Dr Leo Kannerhuis, Autism Clin, Res & Dev, NL-6865 XZ Doorwerth, Netherlands.
   [van den Bergh, Sanne F. W. M.; Geurts, Hilde M.] Univ Amsterdam, Dept Psychol Brain & Cognit, Amsterdam, Netherlands.
   [van den Bergh, Sanne F. W. M.; Geurts, Hilde M.] Dutch Autism & ADHD Res Ctr dArc, NL-1018 XA Amsterdam, Netherlands.
   [Scheeren, Anke M.; Begeer, Sander; Koot, Hans M.] Vrije Univ Amsterdam, Dept Dev Psychol, Amsterdam, Netherlands.
   [Scheeren, Anke M.; Begeer, Sander; Koot, Hans M.] ARA, Amsterdam, Netherlands.
   [Scheeren, Anke M.; Begeer, Sander; Koot, Hans M.] EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
   [Begeer, Sander] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
   [Geurts, Hilde M.] Cognit Sci Ctr Amsterdam, NL-1018 WS Amsterdam, Netherlands.
RP Geurts, HM (reprint author), Dr Leo Kannerhuis, Autism Clin, Res & Dev, Houtsniplaan 1, NL-6865 XZ Doorwerth, Netherlands.
EM s.f.w.m.vandenbergh@uva.nl; h.m.geurts@uva.nl
CR Adams N., 2011, J AUTISM DEV DISORD, V42, P1052
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Anderson VA, 2001, DEV NEUROPSYCHOL, V20, P385, DOI 10.1207/S15326942DN2001_5
   BADDELEY A, 1992, SCIENCE, V255, P556, DOI 10.1126/science.1736359
   Bastiaansen JA, 2011, J AUTISM DEV DISORD, V41, P1256, DOI 10.1007/s10803-010-1157-x
   Berger HJC, 2003, J CLIN EXP NEUROPSYC, V25, P502, DOI 10.1076/jcen.25.4.502.13870
   Best JR, 2009, DEV REV, V29, P180, DOI 10.1016/j.dr.2009.05.002
   Boyd BA, 2009, RES AUTISM SPECT DIS, V3, P959, DOI 10.1016/j.rasd.2009.05.003
   Bramham J, 2009, AUTISM, V13, P245, DOI 10.1177/1362361309103790
   Chan AS, 2009, CLIN NEUROPHYSIOL, V120, P1107, DOI 10.1016/j.clinph.2009.04.002
   Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
   Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256
   Constantino J. N., 2007, SOCIAL RESPONSIVENES
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777
   Davidson MC, 2006, NEUROPSYCHOLOGIA, V44, P2037, DOI 10.1016/j.neuropsychologia.2006.02.006
   De Luca CR, 2003, J CLIN EXP NEUROPSYC, V25, P242, DOI 10.1076/jcen.25.2.242.13639
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   de Vries M, 2012, J AUTISM DEV DISORD, V42, P2558, DOI 10.1007/s10803-012-1512-1
   Dunn L.M., 2005, PEABODY PICTURE VOCA
   Edgin JO, 2005, J AUTISM DEV DISORD, V35, P729, DOI 10.1007/s10803-005-0020-y
   Endedijk H, 2011, LEARN INDIVID DIFFER, V21, P765, DOI 10.1016/j.lindif.2011.07.016
   Field A., 2009, DISCOVERING STAT USI
   Friedman NP, 2004, J EXP PSYCHOL GEN, V133, P101, DOI 10.1037/0096-3445.133.1.101
   Gathercole SE, 2004, DEV PSYCHOL, V40, P177, DOI 10.1037/0012-1649.40.2.177
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Geurts HM, 2009, J AUTISM DEV DISORD, V39, P1603, DOI 10.1007/s10803-009-0786-4
   Gioia GA, 2000, CHILD NEUROPSYCHOL, V6, P235, DOI 10.1076/chin.6.3.235.3152
   Gioia GA, 2000, BEHAV RATING INVENTO
   Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P121
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
   Hughes C, 2011, INFANT CHILD DEV, V20, P251, DOI 10.1002/icd.736
   Hughes C., 2009, DEV NEUROPSYCHOL, V35, P20, DOI [10.1080/87565640903325691, DOI 10.1080/87565640903325691]
   Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
   Huizinga M, 2011, CHILD NEUROPSYCHOL, V17, P51, DOI 10.1080/09297049.2010.509715
   Huizinga M., 2012, BRIEF VRAGENLIJST EX
   Kalbfleisch ML, 2012, J AUTISM DEV DISORD, V42, P390, DOI 10.1007/s10803-011-1257-2
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Kenworthy L, 2009, CHILD NEUROPSYCHOL, V15, P425, DOI 10.1080/09297040802646983
   Kenworthy LE, 2005, DEV NEUROPSYCHOL, V28, P809, DOI 10.1207/s15326942dn2803_4
   Lezak MD, 2012, NEUROPSYCHOLOGICAL A, V5th
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luciana M, 2009, DEV NEUROPSYCHOL, V34, P461, DOI 10.1080/87565640902964540
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   Luna B, 2004, CHILD DEV, V75, P1357, DOI 10.1111/j.1467-8624.2004.00745.x
   McAuley T, 2010, J INT NEUROPSYCH SOC, V16, P495, DOI 10.1017/S1355617710000093
   Minshew NJ, 2001, J CHILD PSYCHOL PSYC, V42, P1095, DOI 10.1111/1469-7610.00808
   Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
   Monsell S, 2003, TRENDS COGN SCI, V7, P134, DOI 10.1016/S1364-6613(03)00028-7
   Mosconi M. W., 2009, PSYCHOL MED, V39, P559
   OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027
   Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x
   Pellicano E, 2006, DEV PSYCHOPATHOL, V18, P77, DOI 10.1017/S0954579406060056
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Roeyers H., 2011, SRS SCREENINGSLIJST
   Rosenthal M, 2013, NEUROPSYCHOLOGY, V27, P13, DOI 10.1037/a0031299
   Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
   Scheeren AM, 2010, AUTISM, V14, P457, DOI 10.1177/1362361310366568
   Scheeren AM, 2013, J CHILD PSYCHOL PSYC, V54, P628, DOI 10.1111/jcpp.12007
   Scheeren AM, 2012, J AUTISM DEV DISORD, V42, P2046, DOI 10.1007/s10803-012-1451-x
   Sinzig J., 2008, CHILD ADOL PSYCH CL, V13, P117
   Smith EE, 1996, CEREB CORTEX, V6, P11, DOI 10.1093/cercor/6.1.11
   Steele SD, 2007, J AUTISM DEV DISORD, V37, P605, DOI 10.1007/s10803-006-0202-2
   Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028
   van der Oord S, 2008, EUR CHILD ADOLES PSY, V17, P73, DOI 10.1007/s00787-007-0638-8
   Verte S, 2005, DEV PSYCHOPATHOL, V17, P415, DOI 10.1017/S0954579405050200
   Williams DL, 2005, J AUTISM DEV DISORD, V35, P747, DOI 10.1007/s10803-005-0021-x
   Winsler A, 2007, J AUTISM DEV DISORD, V37, P1617, DOI 10.1007/s10803-006-0294-8
   Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
   Zandt F, 2007, J AUTISM DEV DISORD, V37, P251, DOI 10.1007/s10803-006-0158-2
NR 76
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1959
EP 1971
DI 10.1007/s10803-014-2071-4
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400014
PM 24562693
ER

PT J
AU Filipe, MG
   Frota, S
   Castro, SL
   Vicente, SG
AF Filipe, Marisa G.
   Frota, Sonia
   Castro, Sao Luis
   Vicente, Selene G.
TI Atypical Prosody in Asperger Syndrome: Perceptual and Acoustic
   Measurements
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger syndrome; Atypical prosody; Autism spectrum disorders;
   Intonation
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS; AUTOMATED
   VOCAL ANALYSIS; LANGUAGE-ACQUISITION; SPECTRUM DISORDERS; REVISED
   VERSION; CHILDREN; INTONATION; SPEECH; ADOLESCENTS
AB It is known that individuals with Asperger syndrome (AS) may show no problems with regard to what is said (e.g., lexical content) but tend to have difficulties in how utterances are produced, i.e., they may show prosodic impairments. In the present study, we focus on the use of prosodic features to express grammatical meaning. Specifically, we explored the sentence type difference between statements and questions that is conveyed by intonation, using perceptual and acoustic measurements. Children aged 8 and 9 years with AS (n = 12) were matched according to age and nonverbal intelligence with typically developing peers (n = 17). Although children with AS could produce categorically accurate prosodic patterns, their prosodic contours were perceived as odd by adult listeners, and acoustic measurements showed alterations in duration and pitch. Additionally, children with AS had greater variability in fundamental frequency contours compared to typically developing peers.
C1 [Filipe, Marisa G.; Castro, Sao Luis; Vicente, Selene G.] Univ Porto, Fac Psychol & Educ Sci, Speech Lab, P-4200135 Oporto, Portugal.
   [Frota, Sonia] Univ Lisbon, Ctr Linguist, P-1600214 Lisbon, Portugal.
RP Filipe, MG (reprint author), Univ Porto, Fac Psychol & Educ Sci, Speech Lab, Rua Alfredo Allen, P-4200135 Oporto, Portugal.
EM labfala@fpce.up.pt
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th, DOI [10.1176/appi.books.9780890423349, DOI 10.1176/APPI.BOOKS.9780890423349]
   BALTAXE CAM, 1984, J SPEECH HEAR RES, V27, P97
   Baltaxe C. A. M., 1985, COMMUNICATION PROBLE, P95, DOI 10.1007/978-1-4757-4806-2_7
   Boersma P., 2011, PRAAT DOING PHONETIC
   Bonneh YS, 2011, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00237
   Catterall C, 2006, CLIN LINGUIST PHONET, V20, P531, DOI 10.1080/02699200500266380
   Christophe A, 2001, INFANCY, V2, P385, DOI 10.1207/S15327078IN0203_6
   Christophe A, 1997, LANG COGNITIVE PROC, V12, P585, DOI 10.1080/016909697386637
   CUTLER A, 1987, J CHILD LANG, V14, P145
   Demouy J, 2011, RES AUTISM SPECT DIS, V5, P1402, DOI 10.1016/j.rasd.2011.01.026
   DePape AMR, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00072
   Diehl JJ, 2013, APPL PSYCHOLINGUIST, V34, P135, DOI 10.1017/S0142716411000646
   Diehl JJ, 2009, APPL PSYCHOLINGUIST, V30, P385, DOI 10.1017/S0142716409090201
   Dryer M. S., 2011, WORLD ATLAS LANGUAGE
   Fale I., 2005, P 9 EUR C SPEECH COM, P1705
   Ferreira A. S., 2011, P 8 IB C PSYCH ASS L, P447
   FINE J, 1991, J CHILD PSYCHOL PSYC, V32, P771, DOI 10.1111/j.1469-7610.1991.tb01901.x
   Fletcher P., 1979, LANG ACQUIS, P33, DOI 10.1017/CBO9780511620683.011
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Frota S, 2014, INFANCY, V19, P194, DOI 10.1111/infa.12037
   Frota Sonia, 2002, PROBUS, V14, P113, DOI 10.1515/prbs.2002.001
   Grossman RB, 2013, J SPEECH LANG HEAR R, V56, P1035, DOI 10.1044/1092-4388(2012/12-0067)
   Grossman RB, 2010, J SPEECH LANG HEAR R, V53, P778, DOI 10.1044/1092-4388(2009/08-0127)
   Gussenhoven C., 2004, PHONOLOGY TONE INTON, DOI [10.1017/CBO9780511616983, DOI 10.1017/CBO9780511616983]
   Harn W. E., 2007, AM SPEECH LANGUAGE H
   Hohle B, 2009, LINGUISTICS, V47, P359, DOI 10.1515/LING.2009.013
   Jarvinen-Pasley A, 2008, J AUTISM DEV DISORD, V38, P1328, DOI 10.1007/s10803-007-0520-z
   Kanner L, 1943, NERV CHILD, V2, P217
   Klin A., 2000, ASPERGER SYNDROME
   Koegel LK, 2010, J AUTISM DEV DISORD, V40, P509, DOI 10.1007/s10803-009-0896-z
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   McCann J, 2007, INT J LANG COMM DIS, V42, P682, DOI 10.1080/13682820601170102
   McCann J, 2003, INT J LANG COMM DIS, V38, P325, DOI 10.1080/1368282031000154204
   MEHLER J, 1988, COGNITION, V29, P143, DOI 10.1016/0010-0277(88)90035-2
   Morgan JL, 1996, SIGNAL TO SYNTAX: BOOTSTRAPPING FROM SPEECH TO GRAMMAR IN EARLY ACQUISITION, P1
   Nadig A, 2012, J AUTISM DEV DISORD, V42, P499, DOI 10.1007/s10803-011-1264-3
   Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107
   Parker A, 1990, DEV SPEECH DISORDERS, P83
   Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
   Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
   Peppe S, 2003, CLIN LINGUIST PHONET, V17, P345, DOI 10.1080/0269920031000079994
   Peppe S, 2011, J NEUROLINGUIST, V24, P41, DOI 10.1016/j.jneuroling.2010.07.005
   Peppe S., 1998, THESIS U COLL LONDON
   Peppe S., 2007, P 16 INT C PHON SCI, P8
   Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
   Raven J. C., 1995, MANUAL COLOURED PROG
   Schoen E., 2010, CHILD SPEECH SOUND D, P181
   Sharda M, 2010, NEUROSCI LETT, V478, P42, DOI 10.1016/j.neulet.2010.04.066
   Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
   Simoes M., 2000, INVESTIGACOES AMBITO
   Staunton R., 1994, 1 LANGUAGE, V14, P241, DOI 10.1177/014272379401404216
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
   Tobin Y., 2009, INT J SPEECH LANGUAG, V11, P308, DOI 10.1080/17549500903003060
   Wagner M, 2010, LANG COGNITIVE PROC, V25, P905, DOI 10.1080/01690961003589492
   Warren SF, 2010, J AUTISM DEV DISORD, V40, P555, DOI 10.1007/s10803-009-0902-5
   Wells B, 2003, J SPEECH LANG HEAR R, V46, P5, DOI 10.1044/1092-4388(2003/001)
   World Health Organization, 1992, INT CLASS DIS 10 VER
NR 58
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1972
EP 1981
DI 10.1007/s10803-014-2073-2
PG 10
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400015
PM 24590408
ER

PT J
AU Zainal, H
   Magiati, I
   Tan, JWL
   Sung, M
   Fung, DSS
   Howlin, P
AF Zainal, Hani
   Magiati, Iliana
   Tan, Julianne Wen-Li
   Sung, Min
   Fung, Daniel S. S.
   Howlin, Patricia
TI A Preliminary Investigation of the Spence Children's Anxiety Parent
   Scale as a Screening Tool for Anxiety in Young People with Autism
   Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Anxiety; Assessment; Screening; Psychometric;
   Measurement
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING CHILDREN;
   PSYCHOMETRIC PROPERTIES; ASPERGER-SYNDROME; DISCRIMINANT VALIDITY;
   PSYCHIATRIC-DISORDERS; INTERVIEW SCHEDULE; CONTROLLED-TRIAL;
   ADOLESCENTS; YOUTH
AB Despite high rates of clinically elevated anxiety difficulties in children and adolescents with autism spectrum disorders (ASDs), very few studies have systematically examined the usefulness of commonly used caregiver report anxiety screening tools with this population. This study investigated the use of the Spence Children's Anxiety Scale-Parent version (SCAS-P) as a screening tool for anxiety disorders when compared to a standardized DSM-IV-TR-based clinical interview, the Kiddie-Schedule for Schizophrenia and Affective Disorders-Present and Lifetime version (K-SADS-PL). Thirty-two caregivers of youth with a clinical diagnosis of ASD (mean age 10.3 years) attending a specialist autism school participated in this study. They first completed the SCAS-P, a measure of adaptive functioning and a checklist of other emotional and behavioral difficulties. They were then interviewed with the K-SADS-PL. Internal consistency for the SCAS Total score was .88, but Cronbach's alphas were <.70 in three of the six SCAS-P subscales. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the SCAS-P against K-SADS diagnosis were .75, .71, .27, and .95, respectively. All values were >.70, except for the PPV. Evidence of convergent validity between the SCAS-P, K-SADS-PL and DBC anxiety subscale was also found. The high false positive rates notwithstanding, the preliminary data of acceptable to excellent sensitivity, specificity and NPV values tentatively suggest that the SCAS-P may be useful for screening non-help seeking young people with ASD for elevated anxiety symptoms. Further replication in larger studies is needed and ways in which the SCAS-P could be further developed and investigated for use with youth with ASD are discussed.
C1 [Zainal, Hani; Magiati, Iliana; Tan, Julianne Wen-Li] Natl Univ Singapore, Dept Psychol, Singapore 117570, Singapore.
   [Sung, Min; Fung, Daniel S. S.] Inst Mental Hlth, Dept Child & Adolescent Psychiat, Buangkok, Singapore.
   [Howlin, Patricia] Kings Coll London, Fac Hlth Sci, Inst Psychiat, London WC2R 2LS, England.
   [Howlin, Patricia] Univ Sydney, Sydney, NSW 2006, Australia.
RP Magiati, I (reprint author), Natl Univ Singapore, Dept Psychol, AS4,9 Arts Link, Singapore 117570, Singapore.
EM psyim@nus.edu.sg
CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Aschenbrand SG, 2005, J CLIN CHILD ADOLESC, V34, P735, DOI 10.1207/s15374424jccp3404_15
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
   Birmaher B, 1997, J AM ACAD CHILD PSY, V36, P545, DOI 10.1097/00004583-199704000-00018
   Birmaher B, 1999, J AM ACAD CHILD PSY, V38, P1230, DOI 10.1097/00004583-199910000-00011
   Bodden DHM, 2009, BEHAV RES THER, V47, P418, DOI 10.1016/j.brat.2009.01.015
   Brereton A. V., 2002, J AM ACAD CHILD ADOL, V41, P1
   Bruininks R., 1996, SCALES INDEPENDENT B
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
   Chorpita BF, 2005, BEHAV RES THER, V43, P309, DOI 10.1016/j.brat.2004.02.004
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Cosi S, 2010, J ANXIETY DISORD, V24, P129, DOI 10.1016/j.janxdis.2009.09.008
   Einfeld S. L., 2002, MANUAL DEV BEHAV CHE
   Einfeld SL, 1997, AM J MENT RETARD, V102, P45, DOI 10.1352/0895-8017(1997)102<0045:BAEDII>2.0.CO;2
   Farrugia S., 2006, FOCUS AUTISM OTHER D, V21, P25, DOI DOI 10.1177/10883576060210010401
   Fitzgerald M, 2007, CRISIS, V28, P1, DOI 10.1027/0227-5910.28.1.1
   Gadow, 2002, CHILD SYMPTOM INVENT
   Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005
   Green SA, 2010, J AUTISM DEV DISORD, V40, P1495, DOI 10.1007/s10803-010-1007-x
   Greenaway R, 2010, J AUTISM DEV DISORD, V40, P1179, DOI 10.1007/s10803-010-0977-z
   Grondhuis SN, 2012, RES AUTISM SPECT DIS, V6, P1345, DOI 10.1016/j.rasd.2012.04.006
   Hallett V, 2013, J AUTISM DEV DISORD, V43, P2341, DOI 10.1007/s10803-013-1775-1
   Hallett V, 2013, J CHILD PSYCHOL PSYC, V54, P1176, DOI 10.1111/jcpp.12068
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kerns CM, 2013, CLIN PSYCHOL, V19, P323
   Kline P, 1999, HDB PSYCHOL TESTING
   Lecavalier L., 2013, J AUTISM DEV DISORDE
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Li C. J., 2011, J ANXIETY DIORD, V25, P584
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MacNeil BM, 2009, RES AUTISM SPECT DIS, V3, P1, DOI 10.1016/j.rasd.2008.06.001
   Magiati I., FACTORS ASS IN PRESS
   March J., 1998, OCD CHILDREN ADOLESC
   Mason J, 2004, J APPL RES INTELLECT, V17, P85, DOI 10.1111/j.1360-2322.2004.00184.x
   Matilla M.-L., 2010, J AUTISM DEV DISORD, V40, P1080
   Matson J. L., 2007, AUTISM SPECTRUM DISO
   Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P474, DOI 10.1016/j.rasd.2010.06.012
   Mazefsky CA, 2010, AUTISM RES, V3, P120, DOI 10.1002/aur.133
   Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
   Meera SS, 2013, J AUTISM DEV DISORD, V43, P1491, DOI 10.1007/s10803-012-1691-9
   MIDDLETON HA, 1990, AM J MENT RETARD, V94, P669
   Bee LS, 2010, SINGAP MED J, V51, P255
   Nauta M. H., 2005, ANXIETY DISORDERS CH
   Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
   Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071
   Ollendick T. H., 2012, CLIN PSYCHOL-SCI PR, V19, P255
   Ozsivadjian A, 2012, AUTISM, V16, P107, DOI 10.1177/1362361311431703
   PERREAULT WD, 1989, J MARKETING RES, V26, P135, DOI 10.2307/3172601
   Pfeiffer B, 2005, AM J OCCUP THER, V59, P335
   Renno P, 2013, J AUTISM DEV DISORD, V43, P2135, DOI 10.1007/s10803-013-1767-1
   Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
   Reynolds CR, 1985, REVISED CHILDRENS MA
   Rieske D. R., 2013, DEV NEUROREHABIL, V16, P9
   RUPP, 2002, J AM ACAD CHILD ADOL, V41, P1061
   Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
   Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Spence S. A., 1998, J ABNORM PSYCHOL, V106, P280
   Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
   Steinhausen HC, 2004, EUR CHILD ADOLES PSY, V13, P214, DOI 10.1007/s00787-004-0400-4
   Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
   Storch EA, 2012, J AUTISM DEV DISORD, V42, P2374, DOI 10.1007/s10803-012-1489-9
   Storch EA, 2012, J CHILD ADOL PSYCHOP, V22, P292, DOI 10.1089/cap.2011.0114
   Sung M, 2011, CHILD PSYCHIAT HUM D, V42, P634, DOI 10.1007/s10578-011-0238-1
   Trembath D, 2012, FOCUS AUTISM DEV DIS, V27, P213, DOI 10.1177/1088357612454916
   van Steensel F. J., 2012, AUTISM INT J RES PRA
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   Warner J., 2004, ADV PSYCHIAT TREATME, V10, P446, DOI DOI 10.1192/APT.10.6.446
   Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   White SW, 2009, J AUTISM DEV DISORD, V39, P1006, DOI 10.1007/s10803-009-0713-8
   White SW, 2012, J AUTISM DEV DISORD, V42, P1138, DOI 10.1007/s10803-011-1353-3
   Whiteside SP, 2008, J ANXIETY DISORD, V22, P1440, DOI 10.1016/j.janxdis.2008.02.006
   Wigham S., 2014, PLOS ONE, V9, P1
   Woo B. S. C., 2007, SMJ Singapore Medical Journal, V48, P1100
   Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
NR 82
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1982
EP 1994
DI 10.1007/s10803-014-2075-0
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400016
PM 24573336
ER

PT J
AU Hus, V
   Lord, C
AF Hus, Vanessa
   Lord, Catherine
TI The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm
   and Standardized Severity Scores
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Autism Diagnostic Observation Schedule;
   Adults; Severity
ID SPECTRUM DISORDERS; ADULTS; INDIVIDUALS; ADOLESCENTS; INTERVIEW;
   OUTCOMES; CHILDREN; AVERAGE; SCALE; IQ
AB The recently published Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) includes revised diagnostic algorithms and standardized severity scores for modules used to assess younger children. A revised algorithm and severity scores are not yet available for Module 4, used with verbally fluent adults. The current study revises the Module 4 algorithm and calibrates raw overall and domain totals to provide metrics of autism spectrum disorder (ASD) symptom severity. Sensitivity and specificity of the revised Module 4 algorithm exceeded 80 % in the overall sample. Module 4 calibrated severity scores provide quantitative estimates of ASD symptom severity that are relatively independent of participant characteristics. These efforts increase comparability of ADOS scores across modules and should facilitate efforts to examine symptom trajectories from toddler to adulthood.
C1 [Hus, Vanessa; Lord, Catherine] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
   [Hus, Vanessa; Lord, Catherine] Univ Michigan, Autism & Commun Disorders Ctr, Ann Arbor, MI 48109 USA.
RP Hus, V (reprint author), Univ Michigan, Dept Psychol, 530 Church St, Ann Arbor, MI 48109 USA.
EM vhus@umich.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Anderson DK, 2014, J CHILD PSYCHOL PSYC, V55, P485, DOI 10.1111/jcpp.12178
   Bastiaansen JA, 2011, J AUTISM DEV DISORD, V41, P1256, DOI 10.1007/s10803-010-1157-x
   Brown J. D., 1999, SHIKEN JALT TESTING, V3, P20
   Browne MW, 1993, TESTING STRUCTURAL E, V154, P136, DOI DOI 10.1177/0049124192021002005
   Brugha TS, 2012, PSYCHOL MED, V42, P647, DOI 10.1017/S0033291711001292
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297
   Dunn L. M., 2007, PEABODY PICTURE VOCA
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Elliott C. D., 2006, DIFFERENTIAL ABILITY
   Elliott C. D., 1990, DIFFERENTIAL ABILITY
   Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69
   Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037
   Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Gillespie-Lynch K, 2012, J AUTISM DEV DISORD, V42, P161, DOI 10.1007/s10803-011-1222-0
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Henninger NA, 2013, AUTISM, V17, P103, DOI 10.1177/1362361312441266
   Howlin P, 2013, J AM ACAD CHILD PSY, V52, P572, DOI 10.1016/j.jaac.2013.02.017
   Hus V, 2011, J CHILD PSYCHOL PSYC, V52, P753, DOI 10.1111/j.1469-7610.2011.02398.x
   Hus V., 2011, TXB AUTISM SPECTRUM, P49
   Hus V, 2013, J AUTISM DEV DISORD, V43, P371, DOI 10.1007/s10803-012-1576-y
   Hus V., 2011, INT M AUT RES SAN DI
   Hus V, 2013, J CHILD PSYCHOL PSYC, V54, P216, DOI 10.1111/j.1469-7610.2012.02589.x
   Interagency Autism Coordinating Committee, 2011, 2011 INT AUT COORD C
   Jones R. M., 2013, INTERVIEW QUESTIONS
   Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
   Lord C., 2012, AUTISM DIAGNOSTIC 1
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C., 2012, AUTISM DIAGNOSTIC 2
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z
   Perry A., 2002, J DEV DISABILITIES, V9, P61
   Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
   Raven J.C., 1960, GUIDE STANDARD PROGR
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Shattuck PT, 2007, J AUTISM DEV DISORD, V37, P1735, DOI 10.1007/s10803-006-0307-7
   Sigman M, 2005, J AUTISM DEV DISORD, V35, P15, DOI 10.1007/s10803-004-1027-5
   Skrondal A, 2004, GEN LATENT VARIABLE
   US Department of Education, 2011, TABL 1 3 NUMB STUD B
   Wechsler D, 1999, WECHSLER ABBREVIATED
NR 47
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 1996
EP 2012
DI 10.1007/s10803-014-2080-3
PG 17
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400018
PM 24590409
ER

PT J
AU Frazier, TW
   Thompson, L
   Youngstrom, EA
   Law, P
   Hardan, AY
   Eng, C
   Morris, N
AF Frazier, Thomas W.
   Thompson, Lee
   Youngstrom, Eric A.
   Law, Paul
   Hardan, Antonio Y.
   Eng, Charis
   Morris, Nathan
TI A Twin Study of Heritable and Shared Environmental Contributions to
   Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Twins; Genetic; Heritability; Environment; Diagnosis
ID DE-NOVO MUTATIONS; MULTIPLE-REGRESSION ANALYSIS; COPY-NUMBER-VARIATION;
   SPECTRUM DISORDERS; GENERAL-POPULATION; GENETIC ETIOLOGY;
   INDIVIDUAL-DIFFERENCES; PATERNAL AGE; RISK-FACTORS; TRAITS
AB The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels (). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15-0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements.
C1 [Frazier, Thomas W.] Cleveland Clin, Ctr Autism, Cleveland, OH 44195 USA.
   [Frazier, Thomas W.; Eng, Charis] Cleveland Clin, Genom Med Inst, Cleveland, OH 44195 USA.
   [Thompson, Lee] Case Western Reserve Univ, Dept Psychol Sci, Cleveland, OH 44106 USA.
   [Youngstrom, Eric A.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
   [Law, Paul] Kennedy Krieger Inst, Dept Med Informat, Baltimore, MD USA.
   [Law, Paul] Kennedy Krieger Inst, Interact Autism Network, Baltimore, MD USA.
   [Hardan, Antonio Y.] Dept Psychiat & Behav Sci, Stanford, CA USA.
   [Eng, Charis] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA.
   [Morris, Nathan] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA.
RP Frazier, TW (reprint author), Cleveland Clin, Ctr Autism, 9500 Euclid Ave, Cleveland, OH 44195 USA.
EM fraziet2@ccf.org
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   American Psychiatric Association, 2011, 299 AUT DIS
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Benchek PH, 2013, HUM GENET, V132, P1351, DOI 10.1007/s00439-013-1334-z
   Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
   Bortolus R, 1999, HUM REPROD UPDATE, V5, P179, DOI 10.1093/humupd/5.2.179
   Bruder CEG, 2008, AM J HUM GENET, V82, P763, DOI 10.1016/j.ajhg.2007.12.011
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
   CHERNY SS, 1992, BEHAV GENET, V22, P489, DOI 10.1007/BF01066617
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Constantino JN, 2000, AM J PSYCHIAT, V157, P2043, DOI 10.1176/appi.ajp.157.12.2043
   Constantino JN, 2009, J AM ACAD CHILD PSY, V48, P97, DOI 10.1097/CHI.0b013e318193069e
   Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151
   DAVIE AM, 1979, ANN HUM GENET, V42, P507, DOI 10.1111/j.1469-1809.1979.tb00683.x
   DEFRIES JC, 1985, BEHAV GENET, V15, P467, DOI 10.1007/BF01066239
   DEFRIES JC, 1988, ACTA GENET MED GEMEL, V37, P205
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Frazier TW, 2010, ASSESSMENT, V17, P308, DOI 10.1177/1073191109356534
   Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
   Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Grether JK, 2009, AM J EPIDEMIOL, V170, P1118, DOI 10.1093/aje/kwp247
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
   Holmes AS, 2003, INT J TOXICOL, V22, P277, DOI 10.1080/10915810390220054
   Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
   Ingram DG, 2008, J AUTISM DEV DISORD, V38, P950, DOI 10.1007/s10803-007-0469-y
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Ip P, 2004, J CHILD NEUROL, V19, P431
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   KIDD KK, 1973, SOC BIOL, V20, P254
   Knopik VS, 1997, BEHAV GENET, V27, P447, DOI 10.1023/A:1025622400239
   Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Logan JAR, 2012, BEHAV GENET, V42, P256, DOI 10.1007/s10519-011-9497-7
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
   Martin J. A., 2012, 3 DECADES TWIN BIRTH, V80
   McCanlies EC, 2012, J AUTISM DEV DISORD, V42, P2323, DOI 10.1007/s10803-012-1468-1
   Moss J, 2008, J AUTISM DEV DISORD, V38, P1081, DOI 10.1007/s10803-007-0487-9
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Newschaffer CJ, 2002, EPIDEMIOL REV, V24, P137, DOI 10.1093/epirev.mxf010
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Purcell S, 2003, BEHAV GENET, V33, P271, DOI 10.1023/A:1023494408079
   Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
   Rice Catherine, 2009, Morbidity and Mortality Weekly Report, V58, P1
   Rietveld M J, 2000, Twin Res, V3, P134, DOI 10.1375/136905200320565409
   Rijsdijk Frühling V, 2002, Brief Bioinform, V3, P119, DOI 10.1093/bib/3.2.119
   RITVO ER, 1985, AM J PSYCHIAT, V142, P74
   Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
   Robinson EB, 2012, BEHAV GENET, V42, P245, DOI 10.1007/s10519-011-9500-3
   Ronald A, 2005, DEVELOPMENTAL SCI, V8, P444, DOI 10.1111/j.1467-7687.2005.00433.x
   Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
   Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
   Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
   Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
   Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sandin S, 2012, J AM ACAD CHILD PSY, V51, P477, DOI 10.1016/j.jaac.2012.02.018
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Schmidt RJ, 2012, AM J CLIN NUTR, V96, P80, DOI 10.3945/ajcn.110.004416
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
   Skuse DH, 2005, BRIT J PSYCHIAT, V187, P568, DOI 10.1192/bjp.187.6.568
   Spinath FM, 2004, CHILD DEV, V75, P445, DOI 10.1111/j.1467-8624.2004.00685.x
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   STEVENSON J, 1993, J CHILD PSYCHOL PSYC, V34, P1137, DOI 10.1111/j.1469-7610.1993.tb01779.x
   STEVENSON J, 1992, BEHAV GENET, V22, P337, DOI 10.1007/BF01066665
   Stilp RLH, 2010, J AM ACAD CHILD PSY, V49, P267, DOI 10.1016/j.jaac.2009.11.012
   Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238
   Taniai H, 2008, AM J MED GENET B, V147B, P844, DOI 10.1002/ajmg.b.30740
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Zachor DA, 2011, RES DEV DISABIL, V32, P2950, DOI 10.1016/j.ridd.2011.05.007
   Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104
NR 88
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 2013
EP 2025
DI 10.1007/s10803-014-2081-2
PG 13
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400019
PM 24604525
ER

PT J
AU Doobay, AF
   Foley-Nicpon, M
   Ali, SR
   Assouline, SG
AF Doobay, Alissa F.
   Foley-Nicpon, Megan
   Ali, Saba R.
   Assouline, Susan G.
TI Cognitive, Adaptive, and Psychosocial Differences Between High Ability
   Youth With and Without Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Gifted; Intelligence; Adaptive functioning; Psychosocial
ID HIGH-FUNCTIONING AUTISM; DEFICIT HYPERACTIVITY DISORDER;
   INTELLECTUALLY-GIFTED-CHILDREN; ASPERGER-SYNDROME; COMMUNICATION
   ABILITIES; PROCESSING SPEED; LEARNING-DISABILITIES/; WISC-IV;
   INDIVIDUALS; STUDENTS
AB Research on Autism Spectrum Disorder (ASD) is thriving; however, scant empirical research has investigated how ASD manifests in high ability youth. Further research is necessary to accurately differentiate high ability students with ASD from those without the disorder, and thus decrease the risk of misdiagnosis. The purpose of the present study is to provide an empirical account of the intellectual, adaptive, and psychosocial functioning of high ability youth with and without ASD utilizing a group study design. Forty youth with high cognitive ability and ASD and a control group of 41 youth with high cognitive ability and no psychological diagnosis were included in the study. In comparison to the control group, the ASD group showed poorer functioning on measures of processing speed, adaptive skills, and broad psychological functioning, as perceived by parents and teachers. These findings have significant implications for diagnosing ASD among those with high ability, and the development of related psychological and educational interventions to address talent domains and areas of concern.
C1 [Doobay, Alissa F.; Foley-Nicpon, Megan; Assouline, Susan G.] Univ Iowa, Iowa City, IA 52242 USA.
   [Ali, Saba R.] Univ Iowa, Iowa City, IA 52242 USA.
RP Doobay, AF (reprint author), Univ Iowa, 600 Blank Honors Ctr, Iowa City, IA 52242 USA.
EM alissa-doobay@uiowa.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Assouline SG, 2009, GIFTED CHILD QUART, V53, P89, DOI 10.1177/0016986208330565
   Barnhill G., 2000, DIAGNOSTIQUE, V25, P147
   Baum SM, 2001, PSYCHOL SCHOOLS, V38, P477, DOI 10.1002/pits.1036
   Bolte S, 2002, CHILD PSYCHIAT HUM D, V33, P165, DOI 10.1023/A:1020734325815
   Bolte S, 2004, INTELLIGENCE, V32, P121, DOI 10.1016/j.intell.2003.11.002
   Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067
   Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470
   Cederlund M, 2004, DEV MED CHILD NEUROL, V46, P652
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   Corbett BA, 2006, CHILD NEUROPSYCHOL, V12, P335, DOI 10.1080/09297040500350938
   Nicpon MF, 2010, J AUTISM DEV DISORD, V40, P1028, DOI 10.1007/s10803-010-0952-8
   Foley Nicpon M., 2012, GIFTED CHILD Q, V56, P77
   Fombonne E., 2005, HDB AUTISM PERVASIVE, P42
   Gallagher S. A., 2002, UNDERSTANDING OUR GI, V14, P7
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
   Gilchrist A, 2001, J CHILD PSYCHOL PSYC, V42, P227, DOI 10.1017/S0021963001006631
   Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
   Gross M. U. M, 2002, SOCIAL EMOTIONAL DEV, P19
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Huber D. H., 2007, THESIS U IOWA IOWA C
   Kanner L, 1943, NERV CHILD, V2, P217
   KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Klin A., 2000, ASPERGER SYNDROME
   KRANZLER JH, 1994, CONTEMP EDUC PSYCHOL, V19, P447, DOI 10.1006/ceps.1994.1032
   Landa RJ, 2005, J AUTISM DEV DISORD, V35, P557, DOI 10.1007/s10803-005-0001-1
   LEHMAN EB, 1981, GIFTED CHILD QUART, V25, P134, DOI 10.1177/001698628102500311
   Little C., 2002, GIFTED CHILD TODAY M, V25, P58
   Lord C, 2003, AUTISM DIAGNOSTIC OB
   Lovecky D. V., 2004, DIFFERENT MINDS GIFT
   Loveland K. A., 2005, HDB AUTISM PERVASIVE, P247
   Martin LT, 2010, GIFTED CHILD QUART, V54, P31, DOI 10.1177/0016986209352684
   Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081
   Mayes SD, 2003, AUTISM, V7, P65, DOI 10.1177/1362361303007001006
   Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4
   Mayes SD, 2007, CHILD NEUROPSYCHOL, V13, P469, DOI 10.1080/09297040601112773
   McCoach DB, 2001, PSYCHOL SCHOOLS, V38, P403, DOI 10.1002/pits.1029
   Neihart M, 2000, GIFTED CHILD QUART, V44, P222, DOI 10.1177/001698620004400403
   Neihart M, 2002, SOCIAL EMOTIONAL DEV, P93
   Nyden A., 1999, AUTISM, V3, P213, DOI 10.1177/1362361399003003002
   Oliveras-Rentas RE, 2012, J AUTISM DEV DISORD, V42, P655, DOI 10.1007/s10803-011-1289-7
   Peterson J, 2009, GIFTED CHILD QUART, V53, P34, DOI 10.1177/0016986208326553
   PLEDGIE TK, 1982, J SPEC EDUC, V16, P221
   Raiford S. E., 2008, 4 WISC 4 PEAS ED
   Reis SM, 2004, PSYCHOL SCHOOLS, V41, P119, DOI 10.1002/pits.10144
   Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
   ROST DH, 1994, EUR J PSYCHOL EDUC, V9, P15
   Russel J., 1997, AUTISM EXECUTIVE DIS
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sattler J. M., 2008, ASSESSMENT CHILDREN, V5th
   Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6
   SAYLER MF, 1993, GIFTED CHILD QUART, V37, P150, DOI 10.1177/001698629303700403
   Siegel DJ, 1996, J AUTISM DEV DISORD, V26, P389, DOI 10.1007/BF02172825
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Sparrow S., 2005, WISC 4 CLIN USE INTE, P281, DOI 10.1016/B978-012564931-5/50009-8
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Tomanik SS, 2007, J AUTISM DEV DISORD, V37, P921, DOI 10.1007/s10803-006-0227-6
   Touq M., 1998, EUROPEAN J HIGH ABIL, V9, P39
   Vialle W., 2007, ED RES EVALUATION, V13, P569, DOI DOI 10.1080/13803610701786046
   Watkins MW, 2002, EDUC PSYCHOL MEAS, V62, P164, DOI 10.1177/0013164402062001011
   Wechsler D., 2002, WAIS 3 WMS 3 TECHNIC
NR 64
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 2026
EP 2040
DI 10.1007/s10803-014-2082-1
PG 15
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400020
PM 24584434
ER

PT J
AU McGillivray, JA
   Evert, HT
AF McGillivray, J. A.
   Evert, H. T.
TI Group Cognitive Behavioural Therapy Program Shows Potential in Reducing
   Symptoms of Depression and Stress Among Young People with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; CBT intervention; Group; Anxiety; Depression;
   Stress; Negative and anxious self talk
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; RANDOMIZED
   CONTROLLED-TRIAL; ASPERGER-SYNDROME; ANXIETY DISORDERS; SELF-STATEMENTS;
   CHILDREN; INTERVENTION; YOUTH; CBT
AB We examined the efficacy of cognitive behavioural therapy (CBT) delivered in groups on the reduction of symptoms of depression, anxiety and stress in young people on the autism spectrum. Utilising a quasi-experimental design, comparisons were made between individuals allocated to a group intervention program and individuals allocated to a waitlist. Following the intervention program, participants who were initially symptomatic reported significantly lower depression and stress scores on the Depression Anxiety Stress Scales in comparison to individuals on the waitlist. There was no significant change in anxiety related symptoms. The benefits were maintained at 3 and 9 month follow-up. Our findings demonstrate the potential of CBT in a small group setting for assisting young people with ASD who have symptoms of depression and stress.
C1 [McGillivray, J. A.; Evert, H. T.] Deakin Univ, Sch Psychol, Ctr Mental Hlth & Wellbeing Res, Burwood, Vic 3125, Australia.
RP McGillivray, JA (reprint author), Deakin Univ, Sch Psychol, Ctr Mental Hlth & Wellbeing Res, 221 Burwood Highway, Burwood, Vic 3125, Australia.
EM jane.mcgillivray@deakin.edu.au
CR Anderson S, 2006, BEHAV COGN PSYCHOTH, V34, P293, DOI 10.1017/S1352465805002651
   Baron G., 2006, STRESS COPING AUTISM, P42
   Beck A. T., 1963, ARCH GEN PSYCHIAT, V10, P561
   Brandon C., 2007, BEST COPING DEV COPI
   Cardaciotto L, 2004, COGN BEHAV PRACT, V11, P75, DOI 10.1016/S1077-7229(04)80009-9
   Cederlund M, 2010, RES DEV DISABIL, V31, P287, DOI 10.1016/j.ridd.2009.09.006
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Compton SN, 2004, J AM ACAD CHILD PSY, V43, P930, DOI 10.1097/01.chi.0000127589.57468.bf
   Cox B., 1998, PSYCHOL ASSESSMENT, V10, P176
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Dobson D., 2009, EVIDENCE BASED PRACT
   Ellis A., 1962, REASON EMOTIONS PSYC
   Farrugia S., 2006, FOCUS AUTISM OTHER D, V21, P25, DOI DOI 10.1177/10883576060210010401
   Frith U., 1991, AUTISM ASPERGER SYND, P1, DOI 10.1017/CBO9780511526770.001
   Gaus VL, 2007, COGNITIVE BEHAV THER
   Groden J, 2001, J AUTISM DEV DISORD, V31, P207, DOI 10.1023/A:1010755300436
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   HOLLON SD, 1980, COGNITIVE THER RES, V4, P383, DOI 10.1007/BF01178214
   JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
   James A, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004690.pub2
   KENDALL PC, 1989, COGNITIVE THER RES, V13, P81, DOI 10.1007/BF01178491
   Kerns CM, 2012, CLIN PSYCHOL-SCI PR, V19, P323, DOI 10.1111/cpsp.12009
   Klein JB, 2007, J AM ACAD CHILD PSY, V46, P1403, DOI 10.1097/chi.0b013e3180592aaa
   Koenig K., 2010, J CONTEMP PSYCHOTHER, V41, P29, DOI 10.1007/s10879-010-9158-9
   Lang R, 2010, DEV NEUROREHABIL, V13, P53, DOI 10.3109/17518420903236288
   Lickel A, 2012, J AUTISM DEV DISORD, V42, P992, DOI 10.1007/s10803-011-1330-x
   Lochman J., 2009, COGNITIVE BEHAV INTE
   LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   Puleo CM, 2011, J AUTISM DEV DISORD, V41, P275, DOI 10.1007/s10803-010-1047-2
   Reaven JA, 2009, FOCUS AUTISM DEV DIS, V24, P27, DOI 10.1177/1088357608327666
   Scarpa A, 2011, BEHAV COGN PSYCHOTH, V39, P495, DOI 10.1017/S1352465811000063
   Selles RR, 2013, J CHILD FAM STUD, V22, P405, DOI 10.1007/s10826-012-9593-1
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
   Sze K. M., 2007, J CONTEMP PSYCHOTHER, V37, P133, DOI 10.1007/s10879-007-9048-y
   Sze KM, 2008, BEHAV COGN PSYCHOTH, V36, P403, DOI 10.1017/S1352465808004384
   Tolin DF, 2010, CLIN PSYCHOL REV, V30, P710, DOI 10.1016/j.cpr.2010.05.003
   Weiss JA, 2010, CLIN PSYCHOL PSYCHOT, V17, P438, DOI 10.1002/cpp.694
   Wells A, 1997, COGNITIVE THERAPY AN
   White SW, 2013, J AUTISM DEV DISORD, V43, P382, DOI 10.1007/s10803-012-1577-x
   White SW, 2009, J AUTISM DEV DISORD, V39, P1652, DOI 10.1007/s10803-009-0801-9
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   White SW, 2010, CLIN CHILD FAM PSYCH, V13, P77, DOI 10.1007/s10567-009-0062-3
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
NR 46
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 2041
EP 2051
DI 10.1007/s10803-014-2087-9
PG 11
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400021
PM 24634065
ER

PT J
AU Zhang, W
   Yan, TT
   Du, YS
   Liu, XH
AF Zhang, Wei
   Yan, Ting-ting
   Du, Ya-song
   Liu, Xiao-hong
TI Brief Report: Effects of Solution-Focused Brief Therapy Group-Work on
   Promoting Post-traumatic Growth of Mothers Who Have a Child with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Mothers; Post-traumatic growth; Solution-focused brief therapy; Group
   counseling
ID AUTISM SPECTRUM DISORDER; SOCIAL SUPPORT; STRESS; OPTIMISM
AB The study evaluated the impact of solution-focused brief therapy (SFBT) group-work on the post-traumatic growth (PTG) of mothers who have a child with ASD. A quasi-experimental design was used in which 43 mothers participated. 18 mothers in 2 SFBT groups (n = 9 in each group) received a 6-session SFBT group therapy while 25 mothers in a control group received no treatment. The Post-traumatic Growth Inventory was used to measure the PTG levels of the participants at baseline, post-treatment and 6-month follow-up assessments. Mothers who attended SFBT group-work reported higher PTG scores both at post-treatment (t = 4.065, p = .001) and 6-month follow-up (t = 2.980, p = .006) assessments. Further investigations to prove whether SFBT in groups can increase the positivity of clients would promote the use of SFBT.
C1 [Zhang, Wei; Yan, Ting-ting; Liu, Xiao-hong] Second Mil Med Univ, Sch Nursing, Shanghai 200433, Peoples R China.
   [Du, Ya-song] Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
RP Liu, XH (reprint author), Second Mil Med Univ, Sch Nursing, 800 Xiangyin Rd, Shanghai 200433, Peoples R China.
EM xiaohongsmmu@126.com
CR Aspinwall LG, 2010, ANN BEHAV MED, V39, P4, DOI 10.1007/s12160-009-9153-0
   Bannink F. P., 2007, J CONTEMP PSYCHOTHER, V37, P87, DOI 10.1007/s10879-006-9040-y
   Bayat M, 2007, J INTELL DISABIL RES, V51, P702, DOI 10.1111/j.1365-2788.2007.00960.x
   Benson PR, 2012, J AUTISM DEV DISORD, V42, P2597, DOI 10.1007/s10803-012-1517-9
   Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
   Corcoran J, 2009, BRIT J SOC WORK, V39, P234, DOI 10.1093/bjsw/bcm098
   DEJONG P, 1995, SOC WORK, V40, P729
   Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
   Ekas NV, 2011, J AUTISM DEV DISORD, V41, P1202, DOI 10.1007/s10803-010-1142-4
   Gingerich WJ, 2000, FAM PROCESS, V39, P477, DOI 10.1111/j.1545-5300.2000.39408.x
   Hagenaars MA, 2010, J TRAUMA STRESS, V23, P504, DOI 10.1002/jts.20551
   Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
   Kim J. S., 2007, RES SOCIAL WORK PRAC, V18, P107, DOI DOI 10.1177/1049731507307807
   Knekt P, 2008, PSYCHOL MED, V38, P689, DOI 10.1017/S003329170700164X
   Lloyd Helen, 2006, Clin Child Psychol Psychiatry, V11, P367, DOI 10.1177/1359104506064982
   Phelps KW, 2009, J INTELLECT DEV DIS, V34, P133, DOI 10.1080/13668250902845236
   Prati G, 2009, J LOSS TRAUMA, V14, P364, DOI 10.1080/15325020902724271
   Springer David W., 2000, CHILD ADOLESCENT SOC, V17, P431, DOI 10.1023/A:1026479727159
   Tedeschi RG, 1996, J TRAUMA STRESS, V9, P455, DOI 10.1007/BF02103658
   Wang J, 2011, THESIS 2 MILITARY ME
NR 20
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 2052
EP 2056
DI 10.1007/s10803-014-2051-8
PG 5
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400022
PM 24488119
ER

PT J
AU Nuske, HJ
   Vivanti, G
   Dissanayake, C
AF Nuske, Heather J.
   Vivanti, Giacomo
   Dissanayake, Cheryl
TI Brief Report: Evidence for Normative Resting-State Physiology in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Resting-state physiology; Autism; Pupillometry; Baseline; Eye-tracking;
   Autonomic nervous system
ID SPECTRUM DISORDERS; AUTONOMIC RESPONSES; PUPIL SIZE; CHILDREN;
   REACTIVITY; LANGUAGE; AROUSAL; FACES
AB Although the conception of autism as a disorder of abnormal resting-state physiology has a long history, the evidence remains mixed. Using state-of-the-art eye-tracking pupillometry, resting-state (tonic) pupil size was measured in children with and without autism. No group differences in tonic pupil size were found, and tonic pupil size was not related to age or cognitive ability in either group, and nor was it related to autistic symptoms. We suggest that previous findings of hyper-arousal in autism at baseline may be a product of different recording methods, in particular different movement-artifact removal techniques. These results question the notion that autism is associated with a fundamental dysregulation in resting-state physiology. Further research, employing such techniques is needed to confirm these findings.
C1 [Nuske, Heather J.; Vivanti, Giacomo; Dissanayake, Cheryl] La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Melbourne, Vic 3086, Australia.
   [Vivanti, Giacomo] La Trobe Univ, Victorian Autism Specif Early Learning & Care Ctr, Melbourne, Vic 3086, Australia.
RP Dissanayake, C (reprint author), La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Melbourne, Vic 3086, Australia.
EM h.nuske@latrobe.edu.au; g.vivanti@latrobe.edu.au;
   c.dissanayake@latrobe.edu.au
CR American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
   American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
   Anderson CJ, 2013, DEV PSYCHOBIOL, V55, P465, DOI 10.1002/dev.21051
   Anderson CJ, 2009, DEV PSYCHOBIOL, V51, P207, DOI 10.1002/dev.20352
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Blair RJR, 1999, PERS INDIV DIFFER, V26, P477, DOI 10.1016/S0191-8869(98)00154-8
   Chau M., 2005, TECHNICAL REPORT
   Daluwatte C, 2013, J AUTISM DEV DISORD, V43, P1910, DOI 10.1007/s10803-012-1741-3
   Fan XF, 2009, J AUTISM DEV DISORD, V39, P1499, DOI 10.1007/s10803-009-0767-7
   Farzin F, 2009, J AUTISM DEV DISORD, V39, P946, DOI 10.1007/s10803-009-0744-1
   Feineis-Matthews S., 2007, JOURNAL OF AUTISM AN, V38, P776, DOI [10.1007/s10803-007-0443-8, DOI 10.1007/S10803-007-0443-8]
   Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724
   Hofmann S. G., 2006, FOCUS AUTISM OTHER D, V21, P100, DOI DOI 10.1177/10883576060210020101
   HUTT C, 1964, NATURE, V204, P908, DOI 10.1038/204908a0
   JAMES A L, 1984, International Journal of Psychophysiology, V1, P179, DOI 10.1016/0167-8760(84)90037-0
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Lense M., 2011, AUTISM SPECTRUM DISO
   Levine TP, 2012, RES AUTISM SPECT DIS, V6, P177, DOI 10.1016/j.rasd.2011.04.003
   Loewenfeld I. E., 1993, THE PUPIL ANATOMY PH
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
   Martineau J, 2011, J PSYCHIATR RES, V45, P1077, DOI 10.1016/j.jpsychires.2011.01.008
   Mathewson KJ, 2011, AUTISM RES, V4, P98, DOI 10.1002/aur.176
   Ming X, 2005, BRAIN DEV-JPN, V27, P509, DOI 10.1016/j.braindev.2005.01.003
   MINSHEW NJ, 1995, NEUROPSYCHOLOGY, V9, P255, DOI 10.1037//0894-4105.9.2.255
   Mullen EM, 1995, MULLEN SCALES OF EAR
   PALKOVITZ RJ, 1980, J AUTISM DEV DISORD, V10, P347, DOI 10.1007/BF02408294
   Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
   Porges SW, 2013, INT J PSYCHOPHYSIOL, V88, P261, DOI 10.1016/j.ijpsycho.2012.11.009
   Riby DM, 2012, J CLIN EXP NEUROPSYC, V34, P385, DOI 10.1080/13803395.2011.645019
   Sepeta L, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-17
   South M, 2012, AUTISM RES, V5, P398, DOI 10.1002/aur.1255
   South M, 2011, AUTISM RES, V4, P412, DOI 10.1002/aur.221
   Stern R. M., 2001, PSYCHOPHYSIOLOGICAL
   Tabachnick B. G., 1996, USING MULTIPLE STATI
   VANENGELAND H, 1991, PSYCHIAT RES, V38, P27, DOI 10.1016/0165-1781(91)90050-Y
   Vaughan Van Hecke A., 2009, CHILD DEV, V80, P1118, DOI DOI 10.1111/J.1467-8624.2009.01320.X
   Waterhouse L, 2013, RETHINKING AUTISM: VARIATION AND COMPLEXITY, P1
   ZAHN TP, 1987, J ABNORM PSYCHOL, V96, P135, DOI 10.1037/0021-843X.96.2.135
NR 39
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 2057
EP 2063
DI 10.1007/s10803-014-2068-z
PG 7
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400023
PM 24550080
ER

PT J
AU Hartley, C
   Allen, ML
AF Hartley, Calum
   Allen, Melissa L.
TI Brief Report: Generalisation of Word-Picture Relations in Children with
   Autism and Typically Developing Children
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Words; Understanding pictures; Generalisation; Shape bias;
   Colour
ID DISORDERS; COMMUNICATION; LANGUAGE; SHAPE
AB We investigated whether low-functioning children with autism generalise labels from colour photographs based on sameness of shape, colour, or both. Children with autism and language-matched controls were taught novel words paired with photographs of unfamiliar objects, and then sorted pictures and objects into two buckets according to whether or not they were also referents of the newly-learned labels. Stimuli matched depicted referents on shape and/or colour. Children with autism extended labels to items that matched depicted objects on shape and colour, but also frequently generalised to items that matched on only shape or colour. Controls only generalised labels to items that matched the depicted referent's shape. Thus, low-functioning children with autism may not understand that shape constrains symbolic word-picture-object relations.
C1 [Hartley, Calum; Allen, Melissa L.] Univ Lancaster, Dept Psychol, Lancaster LA1 4YF, Lancs, England.
RP Hartley, C (reprint author), Univ Lancaster, Dept Psychol, Lancaster LA1 4YF, Lancs, England.
EM hartleyc@exchange.lancs.ac.uk
CR Anderson DK, 2007, J CONSULT CLIN PSYCH, V75, P594, DOI 10.1037/0022-006X.75.4.594
   BaronCohen S, 1997, CHILD DEV, V68, P48
   Bloom P, 2002, MIND LANG, V17, P37, DOI 10.1111/1468-0017.00188
   Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
   FRITH U, 1994, PHILOS T ROY SOC B, V346, P97, DOI 10.1098/rstb.1994.0133
   Frost L., 2002, PECS TRAINING MANUAL
   Hartley C, 2015, J AUTISM DEV DISORD, V45, P15, DOI 10.1007/s10803-013-2007-4
   Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
   POSNER MI, 1970, J EXP PSYCHOL, V83, P304, DOI 10.1037/h0028558
   Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080
   LANDAU B, 1988, COGNITIVE DEV, V3, P299, DOI 10.1016/0885-2014(88)90014-7
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Preissler MA, 2004, J COGN DEV, V5, P185, DOI 10.1207/s15327647jcd0502_2
   Preissler MA, 2008, AUTISM, V12, P231, DOI 10.1177/1362361307088753
   Roid G., 1997, LEITER INT PERFORMAN
   Samuelson LK, 1999, COGNITION, V73, P1, DOI 10.1016/S0010-0277(99)00034-7
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Smith L. B., 2006, P 28 ANN C COGN SCI
   Smith LB, 2002, PSYCHOL SCI, V13, P13, DOI 10.1111/1467-9280.00403
   Tek S, 2008, AUTISM RES, V1, P208, DOI 10.1002/aur.38
   YOUNGER B, 1990, J EXP CHILD PSYCHOL, V50, P131, DOI 10.1016/0022-0965(90)90036-8
NR 22
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2014
VL 44
IS 8
BP 2064
EP 2071
DI 10.1007/s10803-014-2074-1
PG 8
WC Psychology, Developmental
SC Psychology
GA AM3DN
UT WOS:000339732400024
PM 24557810
ER

PT J
AU McGrath, LM
   Yu, DM
   Marshall, C
   Davis, LK
   Thiruvahindrapuram, B
   Li, BB
   Cappi, C
   Gerber, G
   Wolf, A
   Schroeder, FA
   Osiecki, L
   O'Dushlaine, C
   Kirby, A
   Illmann, C
   Haddad, S
   Gallagher, P
   Fagerness, JA
   Barr, CL
   Bellodi, L
   Benarroch, F
   Bienvenu, OJ
   Black, DW
   Bloch, MH
   Bruun, RD
   Budman, CL
   Camarena, B
   Cath, DC
   Cavallini, MC
   Chouinard, S
   Coric, V
   Cullen, B
   Delorme, R
   Denys, D
   Derks, EM
   Dion, Y
   Rosario, MC
   Eapen, V
   Evans, P
   Falkai, P
   Fernandez, TV
   Garrido, H
   Geller, D
   Grabe, HJ
   Grados, MA
   Greenberg, BD
   Gross-Tsur, V
   Gruenblatt, E
   Heiman, GA
   Hemmings, SMJ
   Herrera, LD
   Hounie, AG
   Jankovic, J
   Kennedy, JL
   King, RA
   Kurlan, R
   Lanzagorta, N
   Leboyer, M
   Leckman, JF
   Lennertz, L
   Lochner, C
   Lowe, TL
   Lyon, GJ
   Macciardi, F
   Maier, W
   McCracken, JT
   McMahon, W
   Murphy, DL
   Naarden, AL
   Neale, BM
   Nurmi, E
   Pakstis, AJ
   Pato, MT
   Pato, CN
   Piacentini, J
   Pittenger, C
   Pollak, Y
   Reus, VI
   Richter, MA
   Riddle, M
   Robertson, MM
   Rosenberg, D
   Rouleau, GA
   Ruhrmann, S
   Sampaio, AS
   Samuels, J
   Sandor, P
   Sheppard, B
   Singer, HS
   Smit, JH
   Stein, DJ
   Tischrield, JA
   Vallada, H
   Veenstra-VanderWeele, J
   Walitza, S
   Wang, Y
   Wendfand, JR
   Shugart, YY
   Miguel, EC
   Nicolini, H
   Oostra, BA
   Moessner, R
   Wagner, M
   Ruiz-Linares, A
   Heutink, P
   Nestadt, G
   Freimer, N
   Petryshen, T
   Posthuma, D
   Jenike, MA
   Cox, NJ
   Hanna, GL
   Brentani, H
   Scherer, SW
   Arnold, PD
   Stewart, SE
   Mathews, CA
   Knowles, JA
   Cook, EH
   Pauls, DL
   Wang, K
   Scharf, JM
AF McGrath, Lauren M.
   Yu, Dongmei
   Marshall, Christian
   Davis, Lea K.
   Thiruvahindrapuram, Bhooma
   Li, Bingbin
   Cappi, Carolina
   Gerber, Gloria
   Wolf, Aaron
   Schroeder, Frederick A.
   Osiecki, Lisa
   O'Dushlaine, Colm
   Kirby, Andrew
   Illmann, Cornelia
   Haddad, Stephen
   Gallagher, Patience
   Fagerness, Jesen A.
   Barr, Cathy L.
   Bellodi, Laura
   Benarroch, Fortu
   Bienvenu, O. Joseph
   Black, Donald W.
   Bloch, Michael H.
   Bruun, Ruth D.
   Budman, Cathy L.
   Camarena, Beatriz
   Cath, Danielle C.
   Cavallini, Maria C.
   Chouinard, Sylvain
   Coric, Vladimir
   Cullen, Bernadette
   Delorme, Richard
   Denys, Damiaan
   Derks, Eske M.
   Dion, Yves
   Rosario, Maria C.
   Eapen, Valsama
   Evans, Patrick
   Falkai, Peter
   Fernandez, Thomas V.
   Garrido, Helena
   Geller, Daniel
   Grabe, Hans J.
   Grados, Marco A.
   Greenberg, Benjamin D.
   Gross-Tsur, Varda
   Gruenblatt, Edna
   Heiman, Gary A.
   Hemmings, Sian M. J.
   Herrera, Luis D.
   Hounie, Ana G.
   Jankovic, Joseph
   Kennedy, James L.
   King, Robert A.
   Kurlan, Roger
   Lanzagorta, Nuria
   Leboyer, Marion
   Leckman, James F.
   Lennertz, Leonhard
   Lochner, Christine
   Lowe, Thomas L.
   Lyon, Gholson J.
   Macciardi, Fabio
   Maier, Wolfgang
   McCracken, James T.
   McMahon, William
   Murphy, Dennis L.
   Naarden, Allan L.
   Neale, Benjamin M.
   Nurmi, Erika
   Pakstis, Andrew J.
   Pato, Michele T.
   Pato, Carlos N.
   Piacentini, John
   Pittenger, Christopher
   Pollak, Yehuda
   Reus, Victor I.
   Richter, Margaret A.
   Riddle, Mark
   Robertson, Mary M.
   Rosenberg, David
   Rouleau, Guy A.
   Ruhrmann, Stephan
   Sampaio, Aline S.
   Samuels, Jack
   Sandor, Paul
   Sheppard, Brooke
   Singer, Harvey S.
   Smit, Jan H.
   Stein, Dan J.
   Tischrield, Jay A.
   Vallada, Homero
   Veenstra-VanderWeele, Jeremy
   Walitza, Susanne
   Wang, Ying
   Wendfand, Jens R.
   Shugart, Yin Yao
   Miguel, Euripedes C.
   Nicolini, Humberto
   Oostra, Ben A.
   Moessner, Rainald
   Wagner, Michael
   Ruiz-Linares, Andres
   Heutink, Peter
   Nestadt, Gerald
   Freimer, Nelson
   Petryshen, Tracey
   Posthuma, Danielle
   Jenike, Michael A.
   Cox, Nancy J.
   Hanna, Gregory L.
   Brentani, Helena
   Scherer, Stephen W.
   Arnold, Paul D.
   Stewart, S. Evelyn
   Mathews, Carol A.
   Knowles, James A.
   Cook, Edwin H.
   Pauls, David L.
   Wang, Kai
   Scharf, Jeremiah M.
TI Copy Number Variation in Obsessive-Compulsive Disorder and Tourette
   Syndrome: A Cross-Disorder Study
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Tourette syndrome; obsessive-compulsive disorder; copy number variation;
   genetics; 16p13.11
ID RARE CHROMOSOMAL DELETIONS; GENOME-WIDE ASSOCIATION; DE-NOVO CNVS;
   DEVELOPMENTAL-DISABILITIES; 16P13.11 PREDISPOSE; VARIANTS; DUPLICATIONS;
   AUTISM; SCHIZOPHRENIA; GENETICS
AB Objective: Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (<1%) copy number variants (CNVs) in OCD and the largest genome-wide CNV analysis in TS to date. Method: The primary analyses used a cross-disorder design for 2,699 case patients (1,613 ascertained for OCD, 1,086 ascertained for TS) and 1,789 controls. Parental data facilitated a de novo analysis in 348 OCD trios. Results: Although no global CNV burden was detected in the cross-disorder analysis or in secondary, disease-specific analyses, there was a 3.3-fold increased burden of large deletions previously associated with other neurodevelopmental disorders (p = .09). Half of these neurodevelopmental deletions were located in a single locus, 16p13.11 (5 case patient deletions: 0 control deletions, p = .08 in the current study, p = .025 compared to published controls). Three 16p13.11 deletions were confirmed de novo, providing further support for the etiological significance of this region. The overall OCD de novo rate was 1.4%, which is intermediate between published rates in controls (0.7%) and in individuals with autism or schizophrenia (2-4%). Conclusion: Several converging lines of evidence implicate 16p13.11 deletions in OCD, with weaker evidence for a role in TS. The trend toward increased overall neurodevelopmental CNV burden in TS and OCD suggests that deletions previously associated with other neurodevelopmental disorders may also contribute to these phenotypes.
C1 [Haddad, Stephen; Fagerness, Jesen A.; Petryshen, Tracey] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Stewart, S. Evelyn] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
   [McGrath, Lauren M.] Amer Univ, Washington, DC 20016 USA.
   [Scharf, Jeremiah M.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [McGrath, Lauren M.; O'Dushlaine, Colm; Neale, Benjamin M.] Harvard Brood Inst, Boston, MA USA.
   [Marshall, Christian; Barr, Cathy L.] Univ Toronto, Toronto, ON, Canada.
   [Marshall, Christian; Barr, Cathy L.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Schroeder, Frederick A.; Barr, Cathy L.] Univ Hlth Network, Toronto Western Res Inst, Toronto, ON, Canada.
   [Kennedy, James L.] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Davis, Lea K.; Evans, Patrick] Univ Chicago, Chicago, IL 60637 USA.
   [Vallada, Homero; Miguel, Euripedes C.] Univ Sao Paulo, Med School, BR-05508 Sao Paulo, Brazil.
   [Bellodi, Laura] Univ Vita Salute Son Raffaele, Milan, Italy.
   [Benarroch, Fortu] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel.
   [Bienvenu, O. Joseph; Cullen, Bernadette; Grados, Marco A.; Samuels, Jack; Singer, Harvey S.; Nestadt, Gerald] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Black, Donald W.] Univ Iowa, Coll Med, Iowa City, IA USA.
   [Bloch, Michael H.; Coric, Vladimir; Fernandez, Thomas V.; Leckman, James F.; Pakstis, Andrew J.; Pittenger, Christopher] Yale Univ, Sch Med, New Haven, CT USA.
   [Bruun, Ruth D.; Budman, Cathy L.] North Shore Long Isl Jewish Med Ctr, New Hyde Pk, NY USA.
   [Budman, Cathy L.] Hofstra Univ, Sch Med, Hempstead, NY USA.
   [Bruun, Ruth D.] NYU, Med Ctr, New York, NY 10016 USA.
   [Camarena, Beatriz] Inst Nacl Psiquiatria Ramon Fuente Muniz, Mexico City, DF, Mexico.
   [Cath, Danielle C.] Univ Utrecht, Amsterdam, Netherlands.
   [Cath, Danielle C.] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.
   [Smit, Jan H.] Vrije Univ Amsterdam, Amsterdam, Netherlands.
   [Cavallini, Maria C.] Osped San Raffoe, Milan, Italy.
   [Chouinard, Sylvain; Dion, Yves] Univ Montreal, Montreal, PQ H3C 3J7, Canada.
   [Delorme, Richard; Leboyer, Marion] Robert Debre Univ Hosp, Paris, France.
   [Delorme, Richard; Dion, Yves] French Notional Sci Fdn, Creteil, France.
   [Delorme, Richard] Inst Pasteur, Paris, France.
   [Leboyer, Marion] Inst Mondor Rech Biomed, Creteil, France.
   [Denys, Damiaan] Netherlands Inst Neurosci, Amsterdam, Netherlands.
   [Denys, Damiaan; Derks, Eske M.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands.
   [Sampaio, Aline S.] Univ Fed Sao Paulo, Sao Paulo, Brazil.
   [Sampaio, Aline S.] Univ Fed Bahia, Salvador, BA, Brazil.
   [Eapen, Valsama] Univ New S Wales, Sydney, NSW 2052, Australia.
   [Falkai, Peter] Univ Munich, D-81377 Munich, Germany.
   [Garrido, Helena] Hosp Nacl Ninos Dr Carlos Saenz Herrera, San Jose, Costa Rica.
   [Garrido, Helena] Clin Herrera Amighetti, San Jose, Costa Rica.
   [Grabe, Hans J.] Univ Med Greifswald, Greifswold, Germany.
   [Greenberg, Benjamin D.] Brown Med Sch, Providence, RI USA.
   [Gross-Tsur, Varda; Pollak, Yehuda] Shoare Zedek Med Ctr, Jerusalem, Israel.
   [Gruenblatt, Edna] Univ Zurich, CH-8006 Zurich, Switzerland.
   [Walitza, Susanne] Univ Wurzburg, Wurzburg, Germany.
   [Heiman, Gary A.] Rutgers State Univ, Piscataway Township, NJ USA.
   [Jankovic, Joseph] Baylor Coll Med, Houston, TX 77030 USA.
   [Kurlan, Roger] Atlant Neurosci Inst, Summit, NJ USA.
   [Lanzagorta, Nuria] Corracci Med Grp, Mexico City, DF, Mexico.
   [Lennertz, Leonhard; Maier, Wolfgang; Wagner, Michael] Univ Bonn, Bonn, Germany.
   [Hemmings, Sian M. J.] Univ Stellenbosch, ZA-7600 Stellenbosch, South Africa.
   [Lowe, Thomas L.; Sheppard, Brooke] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lyon, Gholson J.] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
   [McCracken, James T.] Univ Calif Irvine, Irvine, CA USA.
   [Freimer, Nelson] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA.
   [Freimer, Nelson] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA.
   [McMahon, William] Univ Utah, Salt Lake City, UT USA.
   [Murphy, Dennis L.; Wendfand, Jens R.] NIMH, Intramural Res Program, Bethesda, MD 20892 USA.
   [Naarden, Allan L.] Med City Dallas Hosp, Dallas, TX USA.
   [Pato, Michele T.; Pato, Carlos N.; Wang, Ying] Zilkho Neurogenet Inst, Los Angeles, CA USA.
   [Richter, Margaret A.] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada.
   [Robertson, Mary M.] UCL, London, England.
   [Rosenberg, David] Wayne State Univ, Detroit, MI USA.
   [Rosenberg, David] Detroit Med Ctr, Detroit, MI USA.
   [Rouleau, Guy A.] Montreal Neurol Inst, Montreal, PQ, Canada.
   [Ruhrmann, Stephan] Univ Cologne, Cologne, Germany.
   [Smit, Jan H.] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.
   [Stein, Dan J.] Univ Cape Town, Rondebosch, South Africa.
   [Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Nashville, TN 37235 USA.
   [Oostra, Ben A.] Erasmus MC, Rotterdam, Netherlands.
   [Heutink, Peter] German Ctr Neurodegenerat Dis, Bonn, Germany.
   [Heutink, Peter] VU Med Ctr Amsterdam, Amsterdam, Netherlands.
   [Posthuma, Danielle] VU Amsterdam & Erasmus Univ, Med Ctr, Rotterdam, Netherlands.
   [Hanna, Gregory L.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Cook, Edwin H.] Univ Illinois, Chicago, IL USA.
RP Scharf, JM (reprint author), Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, 185 Cambridge St, Boston, MA 02114 USA.
EM ischarf@partners.org
RI Scherer, Stephen /B-3785-2013; Stewart, Evelyn/K-6961-2014; Vallada,
   Homero/D-1333-2014; Nurmi, Erika/P-4627-2014; Stein, Dan/A-1752-2008
OI Scherer, Stephen /0000-0002-8326-1999; Vallada,
   Homero/0000-0001-5123-8295; Nurmi, Erika/0000-0003-4893-8957; Stein,
   Dan/0000-0001-7218-7810
FU David Judah Fund; Tourette Syndrome Association; International OCD
   Foundation; National Institutes of Health [TSA International Consortium
   for Genetics] [U01NS40024, R01NS16648, R01MH079489, MH073250,
   K23MH085057, T32MH16259, NS037484, P30NS062691, K20MH01065, R01MH58376,
   R01MH092293]; American Recovery and Re-investment Act (ARRA) awards
   [NS40024-07S1, NS16648-29S1]; New Jersey Center for Tourette Syndrome
   and Associated Disorders; German Research Foundation (DFG) [Fa 241/6-1];
   Ontario Mental Health Foundation; NIH Genes, Environment and Health
   Initiative (GEI) [U01 HG004422]; Gene Environment Association Studies
   (GENEVA) under GEI; NIH GEI [U01HG004438]; National Institute on Alcohol
   Abuse and Alcoholism; National Institute on Drug Abuse; NIH contract
   "High throughput genotyping for studying the genetic contributions to
   human disease" [HHSN268200782096C];  [T32MH018268]
FX This work was supported by grants from the David Judah Fund, the
   Tourette Syndrome Association, the International OCD Foundation, and
   National Institutes of Health (U01NS40024: [D.L.P./J.M.S/TSA
   International Consortium for Genetics]; R01NS16648, R01MH079489, and
   MH073250 [D.L.P.]; K23MH085057 [J.M.S.]; T32MH16259 [L.M.M.]; NS037484
   and P30NS062691 [N.B.F.]; K20MH01065 and R01MH58376 (G.L.H.);
   R01MH092293 [G.A.H./R.A.K./J.A.T.]). Support also came from American
   Recovery and Re-investment Act (ARRA) awards NS40024-07S1 and
   NS16648-29S1 (D.L.P.). This work was also supported by grants from the
   New Jersey Center for Tourette Syndrome and Associated Disorders, the
   German Research Foundation (Fa 241/6-1; DFG), the Ontario Mental Health
   Foundation (M.A.R. and J.L.K.), and T32MH018268 (J.F.L.). Funding
   support for the Study of Addiction: Genetics and Environment (SAGE) was
   provided through the NIH Genes, Environment and Health Initiative (GEI;
   U01 HG004422). SAGE is 1 of the genome-wide association studies funded
   as part of the Gene Environment Association Studies (GENEVA) under GEI.
   Assistance with phenotype harmonization and genotype cleaning, as well
   as with general study coordination, was provided by the GENEVA
   Coordinating Center (U01 HG004446). Assistance with data cleaning was
   provided by the National Center for Biotechnology Information. Support
   for collection of datasets and samples was provided by the Collaborative
   Study on the Genetics of Alcoholism (COGA; U10M008401), the
   Collaborative Genetic Study of Nicotine Dependence (COGEND; P01
   CA089392), and the Family Study of Cocaine Dependence (FSCD; R01
   DA013423). Funding support for genotyping, which was performed at the
   Johns Hopkins University Center for Inherited Disease Research, was
   provided by the NIH GEI (U01HG004438), the National Institute on Alcohol
   Abuse and Alcoholism, the National Institute on Drug Abuse, and the NIH
   contract "High throughput genotyping for studying the genetic
   contributions to human disease" (HHSN268200782096C) The datasets used
   for the analyses described in this manuscript were obtained from dbGaP
   at
   http://www.ncbi.nlm.nlh.gov/projects/gap/cgibin/study.cgi?study_id=phs00
   0092.vl.pl through dbGaP accession number phs000092.vl p None of the
   funding agencies for this protect had any influence on the design or
   conduct of the study; the management, analysis, or interpretation of the
   data; or the preparation, review, or approval of the manuscript.
CR [Anonymous], 2008, NATURE, V455, P237
   Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
   Bolton D, 2007, PSYCHOL MED, V37, P39, DOI 10.1017/S0033291706008816
   Clarke RA, 2009, CASE REPORT MED, V2009
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Davis LK, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003864
   de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
   Delorme R, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-100
   Fernandez TV, 2012, BIOL PSYCHIAT, V71, P392, DOI 10.1016/j.biopsych.2011.09.034
   Firth HV, 2009, AM J HUM GENET, V84, P524, DOI 10.1016/j.ajhg.2009.03.010
   Grados MA, 2009, CURR PSYCHIAT REP, V11, P162
   Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
   Kaminsky EB, 2011, GENET MED, V13, P777, DOI 10.1097/GIM.0b013e31822c79f9
   Kerbeshian J, 2008, PSYCHIAT GENET, V18, P258, DOI 10.1097/YPG.0b013e328306c989
   Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
   Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Mathews CA, 2011, J AM ACAD CHILD PSY, V50, P46, DOI 10.1016/j.jaac.2010.10.004
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Nag A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059061
   O'Rourke JA, 2009, J PSYCHOSOM RES, V67, P533, DOI 10.1016/j.jpsychores.2009.06.006
   Pauls David L, 2010, Dialogues Clin Neurosci, V12, P149
   Pescosolido MF, 2013, J AM ACAD CHILD PSY, V52, P414, DOI 10.1016/j.jaac.2013.01.003
   Pinto D, 2011, NAT BIOTECHNOL, V29, P512, DOI 10.1038/nbt.1852
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Robertson MM, 2006, J PSYCHOSOM RES, V61, P365, DOI 10.1016/j.jpsychores.2006.06.011
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Scharf JM, 2013, MOL PSYCHIATR, V18, P721, DOI 10.1038/mp.2012.69
   Scharf JM, 2012, J AM ACAD CHILD PSY, V51, P192, DOI 10.1016/j.jaac.2011.11.004
   Stewart SE, 2013, MOL PSYCHIATR, V18, P788, DOI 10.1038/mp.2012.85
   Sundaram SK, 2010, NEUROLOGY, V74, P1583, DOI 10.1212/WNL.0b013e3181e0f147
   Thapar A, 2013, J AM ACAD CHILD PSY, V52, P772, DOI 10.1016/j.jaac.2013.05.013
   Ullmann R, 2007, HUM MUTAT, V28, P674, DOI 10.1002/humu.20546
   van Grootheest DS, 2005, TWIN RES HUM GENET, V8, P450, DOI 10.1375/183242705774310060
   Walitza S, 2012, J NEURAL TRANSM, V119, P507, DOI 10.1007/s00702-011-0699-1
   Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
   Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
   Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
NR 40
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2014
VL 53
IS 8
BP 910
EP 919
DI 10.1016/j.jaac.2014.04.022
PG 10
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AM5WY
UT WOS:000339932900011
PM 25062598
ER

PT J
AU Grove, R
   Baillie, A
   Allison, C
   Baron-Cohen, S
   Hoekstra, RA
AF Grove, Rachel
   Baillie, Andrew
   Allison, Carrie
   Baron-Cohen, Simon
   Hoekstra, Rosa A.
TI The latent structure of cognitive and emotional empathy in individuals
   with autism, first-degree relatives and typical individuals
SO MOLECULAR AUTISM
LA English
DT Article
DE Empathy; autism; broader autism phenotype; factor analysis
ID SPECTRUM QUOTIENT AQ; HIGH-FUNCTIONING AUTISM; MALE BRAIN THEORY;
   ASPERGER-SYNDROME; PSYCHOMETRIC ANALYSIS; FAMILY-HISTORY; NORMAL ADULTS;
   FIT INDEXES; VALIDITY; MIND
AB Background: Empathy is a vital component for social understanding involving the ability to recognise emotion (cognitive empathy) and provide an appropriate affective response (emotional empathy). Autism spectrum conditions have been described as disorders of empathy. First-degree relatives may show some mild traits of the autism spectrum, the broader autism phenotype (BAP). Whether both cognitive and emotional empathy, rather than cognitive empathy alone, are impaired in autism and the BAP is still under debate. Moreover the association between various aspects of empathy is unclear. This study aims to examine the relationship between different components of empathy across individuals with varying levels of genetic vulnerability to autism.
   Methods: Factor analyses utilising questionnaire and performance-based task data were implemented among individuals with autism, parents of a child with autism and controls. The relationship between performance-based tasks and behavioural measures of empathy was also explored.
   Results: A four-factor model including cognitive empathy, emotional empathy, social skills and a performance-based factor fitted the data best irrespective of genetic vulnerability. Individuals with autism displayed impairment on all four factors, with parents showing intermediate difficulties. Performance-based measures of empathy were related in almost equal magnitude to cognitive and emotional empathy latent factors and the social skills factor.
   Conclusions: This study suggests individuals with autism have difficulties with multiple facets of empathy, while parents show intermediate impairments, providing evidence for a quantitative BAP. Impaired scores on performance-based measures of empathy, often thought to be pure measures of cognitive empathy, were also related to much wider empathy difficulties than impairments in cognitive empathy alone.
C1 [Grove, Rachel; Baillie, Andrew] Macquarie Univ, Dept Psychol, Ctr Emot Hlth, Sydney, NSW 2109, Australia.
   [Allison, Carrie; Baron-Cohen, Simon; Hoekstra, Rosa A.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Baron-Cohen, Simon] Cambridgeshire & Peterborough NHS Fdn Trust, CLASS Clin, Cambridge, England.
   [Hoekstra, Rosa A.] Open Univ, Fac Sci, Milton Keynes MK7 6AA, Bucks, England.
RP Grove, R (reprint author), Macquarie Univ, Dept Psychol, Ctr Emot Hlth, Sydney, NSW 2109, Australia.
EM rachel.grove@mq.edu.au
FU Medical Research Council (UK); National Health and Medical Research
   Council (Australia) [1017041]
FX Acknowledgements We thank the individuals who participated in the study.
   This work was conducted in association with the NIHR CLAHRC for
   Cambridgeshire and Peterborough NHS Foundation Trust. We acknowledge
   support from the Medical Research Council (UK) (program grant to SB-C).
   RG was supported by a National Health and Medical Research Council
   (Australia) Postgraduate Scholarship (#1017041).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   AKAIKE H, 1987, PSYCHOMETRIKA, V52, P317, DOI 10.1007/BF02294359
   Allison C, 2011, PERS INDIV DIFFER, V51, P829, DOI 10.1016/j.paid.2011.07.005
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2010, DEV SOCIAL COGNITIVE, P125
   Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7
   Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   BENTLER PM, 1990, PSYCHOL BULL, V107, P238, DOI 10.1037//0033-2909.107.2.238
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   Brown T. A., 2006, CONFIRMATORY FACTOR
   Browne MW, 1993, SAGE FOCUS EDITIONS, V154, P136, DOI DOI 10.1080/10705511.2012.687671
   Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
   Constantino J. N., 2011, PEDIATR RES, V69, P55, DOI DOI 10.1203/PDR.0B013E318212EC6E
   Davis M. H., 1980, CATALOG SELECTED DOC, V10, P85
   Davis MH, 1996, EMPATHY SOCIAL PSYCH
   Decety Jean, 2007, Biopsychosoc Med, V1, P22, DOI 10.1186/1751-0759-1-22
   Deutsch F, 1975, AM J PSYCHIAT, V19, P267
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Eisenberg N., 1987, EMPATHY ITS DEV, P3
   French BF, 2006, STRUCT EQU MODELING, V13, P378, DOI 10.1207/s15328007sem1303_3
   GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x
   Goeleven E, 2008, COGNITION EMOTION, V22, P1094, DOI 10.1080/02699930701626582
   Grove R, 2013, J ABNORM PSYCHOL, V122, P600, DOI 10.1037/a0031919
   Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
   Hoffman M., 1987, EMPATHY ITS DEV, P47
   HOGAN R, 1969, J CONSULT CLIN PSYCH, V33, P307, DOI 10.1037/h0027580
   Horwitz E, 2005, TIJDSCHR PSYCHIAT, V47, P291
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   Lundqvist D., 1998, KAROLINSKA DIRECTED
   Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
   Muncer SJ, 2006, PERS INDIV DIFFER, V40, P1111, DOI 10.1016/j.paid.2005.09.020
   Muthen L. K., 2012, MPLUS
   Palermo MT, 2006, AUTISM, V10, P353, DOI 10.1177/1362361306064431
   PERNER J, 1989, CHILD DEV, V60, P689, DOI 10.1111/j.1467-8624.1989.tb02749.x
   Piven J, 1997, AM J PSYCHIAT, V154, P185
   SCHWARZ G, 1978, ANN STAT, V6, P461, DOI 10.1214/aos/1176344136
   SCLOVE SL, 1987, PSYCHOMETRIKA, V52, P333, DOI 10.1007/BF02294360
   Smith A, 2006, PSYCHOL REC, V56, P3
   Smith A, 2009, PSYCHOL REC, V59, P489
   Steiger J. H., 1980, M PSYCH SOC IOW CIT
   Stewart ME, 2009, PERS INDIV DIFFER, V47, P224, DOI 10.1016/j.paid.2009.03.004
   Sucksmith E, 2011, NEUROPSYCHOL REV, V21, P360, DOI 10.1007/s11065-011-9183-9
   Sucksmith E, 2013, NEUROPSYCHOLOGIA, V51, P98, DOI 10.1016/j.neuropsychologia.2012.11.013
   Sutherland A, 2010, BRAIN, V133, P2089, DOI 10.1093/brain/awq122
   Tucker LR, 1973, PSYCHOMETRIKA, V15, P149
   Wakabayashi A, 2006, J AUTISM DEV DISORD, V36, P263, DOI 10.1007/s10803-005-0061-2
   Wakabayashi Akio, 2004, Shinrigaku Kenkyu, V75, P78
   Wallace S, 2010, AUTISM RES, V3, P345, DOI 10.1002/aur.161
   Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 60
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD AUG 1
PY 2014
VL 5
AR 42
DI 10.1186/2040-2392-5-42
PG 10
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AM6KY
UT WOS:000339975000001
PM 25101164
ER

PT J
AU Ladd-Acosta, C
   Hansen, KD
   Briem, E
   Fallin, MD
   Kaufmann, WE
   Feinberg, AP
AF Ladd-Acosta, C.
   Hansen, K. D.
   Briem, E.
   Fallin, M. D.
   Kaufmann, W. E.
   Feinberg, A. P.
TI Common DNA methylation alterations in multiple brain regions in autism
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism; brain; DNA methylation; epigenome; 450 k
ID PAROXYSMAL KINESIGENIC DYSKINESIA; FAMILIAL INFANTILE CONVULSIONS; COPY
   NUMBER VARIATION; EMBRYONIC STEM-CELLS; CPG ISLAND SHORES; SPECTRUM
   DISORDERS; RHEUMATOID-ARTHRITIS; FUNCTIONAL VARIANTS; WIDE ASSOCIATION;
   MUTATIONS
AB Autism spectrum disorders (ASD) are increasingly common neurodevelopmental disorders defined clinically by a triad of features including impairment in social interaction, impairment in communication in social situations and restricted and repetitive patterns of behavior and interests, with considerable phenotypic heterogeneity among individuals. Although heritability estimates for ASD are high, conventional genetic-based efforts to identify genes involved in ASD have yielded only few reproducible candidate genes that account for only a small proportion of ASDs. There is mounting evidence to suggest environmental and epigenetic factors play a stronger role in the etiology of ASD than previously thought. To begin to understand the contribution of epigenetics to ASD, we have examined DNA methylation (DNAm) in a pilot study of postmortem brain tissue from 19 autism cases and 21 unrelated controls, among three brain regions including dorsolateral prefrontal cortex, temporal cortex and cerebellum. We measured over 485 000 CpG loci across a diverse set of functionally relevant genomic regions using the Infinium HumanMethylation450 BeadChip and identified four genome-wide significant differentially methylated regions (DMRs) using a bump hunting approach and a permutation-based multiple testing correction method. We replicated 3/4 DMRs identified in our genome-wide screen in a different set of samples and across different brain regions. The DMRs identified in this study represent suggestive evidence for commonly altered methylation sites in ASD and provide several promising new candidate genes.
C1 [Ladd-Acosta, C.; Fallin, M. D.] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Ladd-Acosta, C.; Hansen, K. D.; Briem, E.; Fallin, M. D.; Feinberg, A. P.] Johns Hopkins Sch Med, Inst Basic Biomed Sci, Ctr Epigenet, Baltimore, MD 21205 USA.
   [Hansen, K. D.] Johns Hopkins Sch Publ Hlth, Dept Biostat, Baltimore, MD USA.
   [Hansen, K. D.] Johns Hopkins Sch Publ Hlth, Inst Med Genet, Baltimore, MD USA.
   [Briem, E.; Feinberg, A. P.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Kaufmann, W. E.] Kennedy Krieger Inst, Baltimore, MD USA.
RP Feinberg, AP (reprint author), Johns Hopkins Sch Med, Inst Basic Biomed Sci, Ctr Epigenet, 855N Wolfe St,Rangos 570, Baltimore, MD 21205 USA.
EM afeinberg@jhu.edu
FU US National Institutes of Health Centers of Excellence in Genomic
   Science [5P50HG003233]; Department of Defense (CDMRP) [AR080125]
FX We thank Daniel Geschwind and Neelroop Parikshak for sharing the PFC and
   TC samples, obtained from the Autism Tissue Program (ATP) of Autism
   Speaks, for these analyses. In addition, we would also like to thank the
   NICHD Brain and Tissue Bank for Neurodevelopmental Disorders at The
   University of Maryland for providing brain samples from the CBL brain
   region. This work was supported by the US National Institutes of Health
   Centers of Excellence in Genomic Science, 5P50HG003233 to APF and
   Department of Defense (CDMRP) AR080125 to APF and WEK.
CR Agostini G, 2010, ARCH PEDIATRIE, V17, P1008, DOI 10.1016/j.arcped.2010.03.002
   Akalin A, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002781
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Amir RE, 1999, NAT GENET, V23, P185
   [Anonymous], 2012, P 2012 AUT SUMM 31 M
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Banerjee-Basu S, 2010, DIS MODEL MECH, V3, P133, DOI 10.1242/dmm.005439
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Bibikova M, 2011, GENOMICS, V98, P288, DOI 10.1016/j.ygeno.2011.07.007
   Carey Benedict, 2012, NY TIMES
   Chen WJ, 2011, NAT GENET, V43, P1252, DOI 10.1038/ng.1008
   Clement JP, 2012, CELL, V151, P709, DOI 10.1016/j.cell.2012.08.045
   Cottrell CE, 2011, AUTISM RES, V4, P189, DOI 10.1002/aur.184
   Davies MN, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-6-r43
   Dawson G, 2012, ARCH GEN PSYCHIAT, P1
   de Vries B, 2012, NEUROLOGY, V79, P2154, DOI 10.1212/WNL.0b013e3182752c30
   Doi A, 2009, NAT GENET, V41, P1350, DOI 10.1038/ng.471
   Du P, 2010, BMC BIOINFORMATICS, V11, DOI 10.1186/1471-2105-11-587
   Dudziec E, 2011, CLIN CANCER RES, V17, P1287, DOI 10.1158/1078-0432.CCR-10-2017
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Feber A, 2011, GENOME RES, V21, P515, DOI 10.1101/gr.109678.110
   Fernandez T, 2008, AM J HUM GENET, V82, P1385, DOI 10.1016/j.ajhg.2008.04.021
   Fradin D, 2010, PLOS ONE, V5, P9
   Fukuoka T, 2010, NEUROSCI RES, V66, P62, DOI 10.1016/j.neures.2009.09.1709
   Gartlan KH, 2010, J IMMUNOL, V185, P3158, DOI 10.4049/jimmunol.0902867
   Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
   Ginsberg MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044736
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Goschnick MW, 2007, MINI-REV MED CHEM, V7, P1248, DOI 10.2174/138955707782795656
   Gratten J, 2013, NAT GENET, V45, P234, DOI 10.1038/ng.2555
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Groen W, 2010, J AM ACAD CHILD PSY, V49, P552, DOI 10.1016/j.jaac.2009.12.023
   Guintivano J, 2013, EPIGENETICS-US, V8, P290, DOI 10.4161/epi.23924
   Hansen K, 2012, MINFI ANAL ILLUMINA
   Hasan KM, 2012, J CHILD NEUROL, V28, P874
   Heron SE, 2012, AM J HUM GENET, V90, P152, DOI 10.1016/j.ajhg.2011.12.003
   Heron SE, 2007, ANN NEUROL, V62, P560, DOI 10.1002/ana.21169
   Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
   Horsthemke B, 2008, AM J MED GENET A, V146A, P2041, DOI 10.1002/ajmg.a.32364
   Houseman EA, 2009, BIOINFORMATICS, V25, P1999, DOI 10.1093/bioinformatics/btp364
   Irizarry RA, 2009, NAT GENET, V41, P178, DOI 10.1038/ng.298
   Jaffe AE, 2012, INT J EPIDEMIOL, V41, P200, DOI 10.1093/ije/dyr238
   James SJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.8
   Jiang YH, 2004, AM J MED GENET A, V131A, P1, DOI 10.1002/ajmg.a.30297
   Krek A, 2005, NAT GENET, V37, P495, DOI 10.1038/ng1536
   Labate A, 2013, EPILEPSY RES, V104, P280, DOI 10.1016/j.eplepsyres.2012.10.014
   Lai EC, 2002, NAT GENET, V30, P363, DOI 10.1038/ng865
   Lee H, 2012, INT J EPIDEMIOL, V41, P188, DOI 10.1093/ije/dyr237
   Lee HY, 2012, CELL REP, V1, P2, DOI 10.1016/j.celrep.2011.11.001
   Li LC, 2002, BIOINFORMATICS, V18, P1427, DOI 10.1093/bioinformatics/18.11.1427
   Li XJ, 2008, DEV CELL, V15, P547, DOI 10.1016/j.devcel.2008.08.014
   Liu Y, 2013, NAT BIOTECHNOL, V31, P142, DOI 10.1038/nbt.2487
   Liu YW, 2013, TRENDS BIOCHEM SCI, V38, P177, DOI 10.1016/j.tibs.2012.12.005
   Marui T, 2011, ACTA PSYCHIAT SCAND, V123, P118, DOI 10.1111/j.1600-0447.2010.01600.x
   Mill J, 2008, AM J HUM GENET, V82, P696, DOI 10.1016/j.ajhg.2008.01.008
   Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
   Nagarajan RP, 2008, AUTISM RES, V1, P169, DOI 10.1002/aur.24
   Nakano K, 2013, ANN RHEUM DIS, V72, P110, DOI 10.1136/annrheumdis-2012-201526
   Newschaffer CJ, 2002, EPIDEMIOL REV, V24, P137, DOI 10.1093/epirev.mxf010
   Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
   OBERLE I, 1991, SCIENCE, V252, P1097, DOI 10.1126/science.252.5009.1097
   Ono S, 2012, J HUM GENET, V57, P338, DOI 10.1038/jhg.2012.23
   Raney BJ, 2011, NUCLEIC ACIDS RES, V39, pD871, DOI 10.1093/nar/gkq1017
   Rao X., 2012, ONCOGENE
   Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
   Raymond GV, 1996, ACTA NEUROPATHOL, V91, P117
   Riant F, 2012, NEUROLOGY, V79, P2122, DOI 10.1212/WNL.0b013e3182752cb8
   Roohi J, 2009, J MED GENET, V46, P176, DOI 10.1136/jmg.2008.057505
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Sabunciyan S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034451
   Sandoval J, 2011, EPIGENETICS-US, V6, P692, DOI 10.4161/epi.6.6.16196
   Schanen NC, 2006, HUM MOL GENET, V15, pR138, DOI 10.1093/hmg/ddl213
   Scholz CJ, 2010, AM J MED GENET B, V153B, P967, DOI 10.1002/ajmg.b.31057
   Shen J, 2013, EPIGENETICS-US, V8, P34, DOI 10.4161/epi.23062
   Shulha HP, 2012, ARCH GEN PSYCHIAT, V69, P314, DOI 10.1001/archgenpsychiatry.2011.151
   Splawski I, 2006, J BIOL CHEM, V281, P22085, DOI 10.1074/jbc.M603316200
   Strogantsev R, 2012, BRIEF FUNCT GENOMICS, V11, P227, DOI 10.1093/bfgp/els018
   Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
   Tsao CY, 2007, J CHILD NEUROL, V22, P1121, DOI 10.1177/0883073807306266
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Volders K, 2011, CURR MOL MED, V11, P204
   Zuo XP, 2012, J BIOL CHEM, V287, P2107, DOI 10.1074/jbc.M111.322644
NR 82
TC 19
Z9 21
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD AUG
PY 2014
VL 19
IS 8
BP 862
EP 871
DI 10.1038/mp.2013.114
PG 10
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AM7IR
UT WOS:000340040200006
PM 23999529
ER

PT J
AU Kenny, EM
   Cormican, P
   Furlong, S
   Kenny, EHG
   Fahey, C
   Kelleher, E
   Ennis, S
   Tropea, D
   Anney, R
   Corvin, P
   Donohoe, G
   Gallagher, L
   Gill, M
   Morris, DW
AF Kenny, E. M.
   Cormican, P.
   Furlong, S.
   Kenny, E. Heron G.
   Fahey, C.
   Kelleher, E.
   Ennis, S.
   Tropea, D.
   Anney, R.
   Corvin, P.
   Donohoe, G.
   Gallagher, L.
   Gill, M.
   Morris, D. W.
TI Excess of rare novel loss-of-function variants in synaptic genes in
   schizophrenia and autism spectrum disorders
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism; loss-of-function; mutation; schizophrenia; sequencing; synapse
ID DE-NOVO MUTATIONS; COPY NUMBER VARIATION; PERVASIVE DEVELOPMENTAL
   DISORDERS; GENOME-WIDE ASSOCIATION; LONG-TERM POTENTIATION; RECURRENT
   REARRANGEMENTS; BIPOLAR DISORDER; TYROSINE KINASE; NMDA RECEPTORS;
   RISK-FACTOR
AB Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that may share an underlying pathology suggested by shared genetic risk variants. We sequenced the exonic regions of 215 genes in 147 ASD cases, 273 SZ cases and 287 controls, to identify rare risk mutations. Genes were primarily selected for their function in the synapse and were categorized as: (1) Neurexin and Neuroligin Interacting Proteins, (2) Post-synaptic Glutamate Receptor Complexes, (3) Neural Cell Adhesion Molecules, (4) DISC1 and Interactors and (5) Functional and Positional Candidates. Thirty-one novel loss-of-function (LoF) variants that are predicted to severely disrupt protein-coding sequence were detected among 2 861 rare variants. We found an excess of LoF variants in the combined cases compared with controls (P = 0.02). This effect was stronger when analysis was limited to singleton LoF variants (P = 0.0007) and the excess was present in both SZ (P = 0.002) and ASD (P = 0.001). As an individual gene category, Neurexin and Neuroligin Interacting Proteins carried an excess of LoF variants in cases compared with controls (P = 0.05). A de novo nonsense variant in GRIN2B was identified in an ASD case adding to the growing evidence that this is an important risk gene for the disorder. These data support synapse formation and maintenance as key molecular mechanisms for SZ and ASD.
C1 [Kenny, E. M.; Cormican, P.; Furlong, S.; Kenny, E. Heron G.; Fahey, C.; Kelleher, E.; Tropea, D.; Anney, R.; Corvin, P.; Donohoe, G.; Gallagher, L.; Gill, M.; Morris, D. W.] Univ Dublin Trinity Coll, Inst Mol Med, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 2, Ireland.
   [Ennis, S.] Univ Coll Dublin, Sch Med & Med Sci, Dublin 2, Ireland.
RP Morris, DW (reprint author), St James Hosp, Inst Mol Med, Dept Psychiat, Neuropsychiat Genet Res Grp, Room 0-80, Dublin 8, Ireland.
EM derek.morris@tcd.ie
FU Health Research Board (HRB Ireland) [HRA/2009/45]; Science Foundation
   Ireland (SFI) [08/IN.1/B1916]; SFI [07/RFP/GEN/F327/EC07]; HRB 4-Year
   PhD Programme in Molecular Medicine at TCD; Trinity Centre for High
   Performance Computing; Health Research Board (Ireland)
FX We sincerely thank all patients who contributed to this study and all
   staff who facilitated their involvement. Funding for this study was
   provided by the Health Research Board (HRB Ireland; HRA/2009/45) and
   Science Foundation Ireland (SFI; 08/IN.1/B1916). Next-generation
   sequencing was performed in TrinSeq (Trinity Genome Sequencing
   Laboratory; http://www.medicine.tcd.ie/sequencing), a core facility
   funded by SFI under Grant No. [07/RFP/GEN/F327/EC07] to Dr Morris. Ms
   Furlong's PhD studentship is funded by the HRB 4-Year PhD Programme in
   Molecular Medicine at TCD. We acknowledge use of the Trinity Biobank
   control sample and support from the Trinity Centre for High Performance
   Computing. This work was supported by grant funding from the Health
   Research Board (Ireland).
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
   Akashi K, 2009, J NEUROSCI, V29, P10869, DOI 10.1523/JNEUROSCI.5531-08.2009
   Ballif BC, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-8
   Barilari M, 2010, BIOL CHEM, V391, P1169, DOI 10.1515/BC.2010.118
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   BEGGS HE, 1994, J CELL BIOL, V127, P825, DOI 10.1083/jcb.127.3.825
   Cain DP, 1995, EPILEPSY RES, V22, P107, DOI 10.1016/0920-1211(95)00029-1
   Camargo LM, 2007, MOL PSYCHIATR, V12, P74, DOI 10.1038/sj.mp.4001880
   Cardno AG, 2000, AM J MED GENET, V97, P12, DOI 10.1002/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.0.CO;2-U
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Cochrane LE, 2010, AUTISM RES, V3, P342, DOI 10.1002/aur.157
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Craddock N, 2010, BRIT J PSYCHIAT, V197, P158, DOI 10.1192/bjp.197.2.158
   DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
   Donohoe G, 2009, ARCH GEN PSYCHIAT, V66, P1045, DOI 10.1001/archgenpsychiatry.2009.139
   Edvardson S, 2012, ANN NEUROL, V71, P569, DOI 10.1002/ana.23524
   Endele S, 2010, NAT GENET, V42, P1021, DOI 10.1038/ng.677
   Fernell E, 2010, RES DEV DISABIL, V31, P680, DOI 10.1016/j.ridd.2010.01.007
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   GRANT SGN, 1992, SCIENCE, V258, P1903, DOI 10.1126/science.1361685
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   GUO LF, 1995, CELL, V81, P233, DOI 10.1016/0092-8674(95)90333-X
   Hill MJ, 2012, HUM MOL GENET, V21, P1018, DOI 10.1093/hmg/ddr532
   Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
   Husi H, 2000, NAT NEUROSCI, V3, P661
   Ingason A, 2011, MOL PSYCHIATR, V16, P17, DOI 10.1038/mp.2009.101
   Strange A, 2012, BIOL PSYCHIAT, V72, P620, DOI 10.1016/j.biopsych.2012.05.035
   Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kenny EM, 2011, DNA RES, V18, P31, DOI 10.1093/dnares/dsq029
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   King BH, 2011, BRAIN RES, V1380, P34, DOI 10.1016/j.brainres.2010.11.031
   Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
   Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
   Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323
   Kumar P, 2009, NAT PROTOC, V4, P1073, DOI 10.1038/nprot.2009.86
   Kurschner C, 1998, MOL CELL NEUROSCI, V11, P161, DOI 10.1006/mcne.1998.0679
   Laumonnier F, 2007, AM J HUM GENET, V80, P205, DOI 10.1086/511441
   Lemire M, 2011, NAT GENET, V43, P391, DOI 10.1038/ng.818
   Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
   Lips ES, 2012, MOL PSYCHIATR, V17, P996, DOI 10.1038/mp.2011.117
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
   Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384
   Mejias R, 2011, P NATL ACAD SCI USA, V108, P4920, DOI 10.1073/pnas.1102233108
   Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
   Moens LN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023450
   Mohrluder J, 2009, FEBS J, V276, P4989, DOI 10.1111/j.1742-4658.2009.07207.x
   Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
   Mudge J, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003625
   Myers RA, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001318
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Donovan MC, 2008, NAT GENET, V40, P1053, DOI 10.1038/ng.201
   O'Dushlaine C, 2011, MOL PSYCHIATR, V16, P286, DOI 10.1038/mp.2010.7
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pearson RD, 2011, NAT GENET, V43, P391
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Reichelt AC, 2012, NEUROPHARMACOLOGY, V62, P1519, DOI 10.1016/j.neuropharm.2011.01.024
   Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
   Sakai Y, 2011, SCI TRANSL MED, V3
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sonnenberg A, 2007, EXP CELL RES, V313, P2189, DOI 10.1016/j.yexcr.2007.03.039
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Sullivan PF, 2012, ARCH GEN PSYCHIAT, V69, P1099, DOI 10.1001/archgenpsychiatry.2012.730
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Tang YP, 1999, NATURE, V401, P63
   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
   Trepanier CH, 2012, FEBS J, V279, P12, DOI 10.1111/j.1742-4658.2011.08391.x
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Vrijenhoek T, 2008, AM J HUM GENET, V83, P504, DOI 10.1016/j.ajhg.2008.09.011
   Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
   Wang DH, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007486
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
NR 86
TC 14
Z9 14
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD AUG
PY 2014
VL 19
IS 8
BP 872
EP 879
DI 10.1038/mp.2013.127
PG 8
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AM7IR
UT WOS:000340040200007
PM 24126926
ER

PT J
AU Gershon, ES
   Grennan, K
   Busnello, J
   Badner, JA
   Ovsiew, F
   Memon, S
   Alliey-Rodriguez, N
   Cooper, J
   Romanos, B
   Liu, C
AF Gershon, E. S.
   Grennan, K.
   Busnello, J.
   Badner, J. A.
   Ovsiew, F.
   Memon, S.
   Alliey-Rodriguez, N.
   Cooper, J.
   Romanos, B.
   Liu, C.
TI A rare mutation of CACNA1C in a patient with bipolar disorder, and
   decreased gene expression associated with a bipolar-associated common
   SNP of CACNA1C in brain
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE bipolar disorder; Timothy syndrome; calcium channel blockers; CACNA1C;
   long QT syndrome
ID TIMOTHY-SYNDROME MUTATION; CALCIUM-CHANNEL BLOCKERS; NEUROPATHOLOGY
   CONSORTIUM; MAJOR DEPRESSION; HEART-FAILURE; MOUSE MODEL; SCHIZOPHRENIA;
   INACTIVATION; CEREBELLUM; POLYMORPHISMS
AB Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that produce delayed inactivation of Cav1.2 voltage-gated calcium channels during cellular action potentials, with greatly increased influx of calcium into the activated cells. The major clinical feature of this syndrome is a long QT interval that results in cardiac arrhythmias. However, TS also includes cognitive impairment, autism and major developmental delays in many of the patients. We observed the appearance of bipolar disorder (BD) in a patient with a previously reported case of TS, who is one of the very few patients to survive childhood. This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression. To combine the CACNA1C perturbations in the presence of BD in this patient and in patients with the common CACNA1C SNP risk allele, we would propose that either increase or decrease in calcium influx in excitable cells can be associated with BD. In treatment of BD with calcium channel blocking drugs, we would predict better response in patients without the risk allele, because they have increased CACNA1C expression.
C1 [Gershon, E. S.; Grennan, K.; Busnello, J.; Badner, J. A.; Ovsiew, F.; Alliey-Rodriguez, N.; Cooper, J.] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
   [Memon, S.] Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
   [Romanos, B.; Liu, C.] Univ Illinois, Dept Psychiat, Chicago, IL 60607 USA.
   [Liu, C.] Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China.
RP Gershon, ES (reprint author), Univ Chicago, Dept Psychiat, 5841 S Maryland Ave MC3077, Chicago, IL 60637 USA.
EM egershon@yoda.bsd.uchicago.edu; liucsxx@gmail.com
FU NIMH [1R01MH094483-01]; NIH [1R01MH080425]; Geraldi Norton Memorial
   Foundation; Eklund family
FX This work was supported by NIMH 1R01MH094483-01 (Dr Gershon) and NIH
   1R01MH080425 (Dr Liu), Geraldi Norton Memorial Foundation, Eklund
   family.
CR Andreasen NC, 2008, BIOL PSYCHIAT, V64, P81, DOI 10.1016/j.biopsych.2008.01.003
   Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108
   Barrett CF, 2008, P NATL ACAD SCI USA, V105, P2157, DOI 10.1073/pnas.0710501105
   Bigos KL, 2010, ARCH GEN PSYCHIAT, V67, P939, DOI 10.1001/archgenpsychiatry.2010.96
   Bremer T, 2006, PHARMACOGENOMICS, V7, P271, DOI 10.2217/14622416.7.3.271
   CALACHE MJ, 1990, BRIT J PSYCHIAT, V157, P458, DOI 10.1192/bjp.157.3.458
   Chen C, 2013, MOL PSYCHIAT
   Colantuoni C, 2011, NATURE, V478, P519, DOI 10.1038/nature10524
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Depil K, 2011, J BIOL CHEM, V286, P31557, DOI 10.1074/jbc.M111.255273
   Erxleben C, 2006, P NATL ACAD SCI USA, V103, P3932, DOI 10.1073/pnas.0511322103
   Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
   Filiou MD, 2012, J PSYCHIATR RES, V46, P1359, DOI 10.1016/j.jpsychires.2012.07.004
   Gillis J, 2012, AM J MED GENET A, V158A, P182, DOI 10.1002/ajmg.a.34355
   Goonasekera SA, 2012, J CLIN INVEST, V122, P280, DOI 10.1172/JCI58227
   Jacobs A, 2006, HEART RHYTHM, V3, P967, DOI 10.1016/j.hrthm.2006.04.024
   Johnson WE, 2007, BIOSTATISTICS, V8, P118, DOI 10.1093/biostatistics/kxj037
   Jorge R, 2003, INT REV PSYCHIATR, V15, P317, DOI 10.1080/09540260310001606700
   Kamide K, 2009, CIRC J, V73, P732
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   Knable Michael B, 2004, Mol Psychiatry, V9, P609, DOI 10.1038/sj.mp.4001527
   Konarski JZ, 2005, J PSYCHIATR NEUROSCI, V30, P178
   Leek JT, 2007, PLOS GENET, V3, P1724, DOI 10.1371/journal.pgen.0030161
   Levy NA, 2000, BIPOLAR DISORD, V2, P108, DOI 10.1034/j.1399-5618.2000.020204.x
   Liu Y, 2011, MOL PSYCHIATR, V16, P2, DOI 10.1038/mp.2009.107
   May A, 2008, NAT CLIN PRACT NEURO, V4, P182, DOI 10.1038/ncpneuro0707
   Nakayama H, 2007, J CLIN INVEST, V117, P2431, DOI 10.1172/JC131060
   Panagiotou OA, 2010, AM J EPIDEMIOL, V172, P869, DOI 10.1093/aje/kwq234
   Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
   Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011, NAT GENET, V43, P977, DOI DOI 10.1038/NG.943
   Rosati B, 2011, J PHYSIOL-LONDON, V589, P3275, DOI 10.1113/jphysiol.2011.210237
   Schlick B, 2010, NEUROSCIENCE, V167, P786, DOI 10.1016/j.neuroscience.2010.02.037
   Schmitt A, 2010, EUR ARCH PSY CLIN N, V260, P101, DOI 10.1007/s00406-009-0017-1
   Shukla D, 2011, CLIN NEUROL NEUROSUR, V113, P435, DOI 10.1016/j.clineuro.2011.02.013
   Smolin B, 2012, INT J NEUROPSYCHOPH, V15, P869, DOI 10.1017/S1461145711001428
   Splawski I, 2005, P NATL ACAD SCI USA, V102, P8089, DOI 10.1073/pnas.0502506102
   Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
   Thiel WH, 2008, CIRCULATION, V118, P2225, DOI 10.1161/CIRCULATIONAHA.108.788067
   Torrey EF, 2000, SCHIZOPHR RES, V44, P151, DOI 10.1016/S0920-9964(99)00192-9
   Torrey EF, 2005, BIOL PSYCHIAT, V57, P252, DOI 10.1016/j.biopsych.2004.10.019
   Gibbs JR, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000952
   van Assema DME, 2012, MOL IMAGING BIOL, V14, P771, DOI 10.1007/s11307-012-0556-0
   Yarotskyy V, 2009, J PHYSIOL-LONDON, V587, P551, DOI 10.1113/jphysiol.2008.161737
NR 43
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD AUG
PY 2014
VL 19
IS 8
BP 890
EP 894
DI 10.1038/mp.2013.107
PG 5
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AM7IR
UT WOS:000340040200009
PM 23979604
ER

PT J
AU Gauglerl, T
   Klei, L
   Sanders, SJ
   Bodea, CA
   Goldberg, AP
   Lee, AB
   Mahajan, ML
   Manaa, D
   Pawitan, YD
   Reichert, J
   Ripke, S
   Sandin, S
   Sklar, P
   Svantesson, O
   Reichenberg, A
   Hultman, CM
   Devlin, B
   Roeder, K
   Buxbaum, JD
AF Gauglerl, Trent
   Klei, Lambertus
   Sanders, Stephan J.
   Bodea, Corneliu A.
   Goldberg, Arthur P.
   Lee, Ann B.
   Mahajan, Milind
   Manaa, Dina
   Pawitan, Yudi
   Reichert, Jennifer
   Ripke, Stephan
   Sandin, Sven
   Sklar, Pamela
   Svantesson, Oscar
   Reichenberg, Abraham
   Hultman, Christina M.
   Devlin, Bernie
   Roeder, Kathryn
   Buxbaum, Joseph D.
TI Most genetic risk for autism resides with common variation
SO NATURE GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; HERITABILITY; VARIANTS; REVEALS;
   LOCI
AB A key component of genetic architecture is the allelic spectrum influencing trait variability. For autism spectrum disorder (herein termed autism), the nature of the allelic spectrum is uncertain. Individual risk-associated genes have been identified from rare variation, especially de novo mutations(1-8). From this evidence, one might conclude that rare variation dominates the allelic spectrum in autism, yet recent studies show that common variation, individually of small effect, has substantial impact en masse(9,10). At issue is how much of an impact relative to rare variation this common variation has. Using a unique epidemiological sample from Sweden, new methods that distinguish total narrow-sense heritability from that due to common variation and synthesis of results from other studies, we reach several conclusions about autism's genetic architecture: its narrow-sense heritability is similar to 52.4%, with most due to common variation, and rare de novo mutations contribute substantially to individual liability, yet their contribution to variance in liability, 2.6%, is modest compared to that for heritable variation.
C1 [Gauglerl, Trent; Bodea, Corneliu A.; Lee, Ann B.; Roeder, Kathryn] Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA.
   [Klei, Lambertus; Devlin, Bernie] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Sanders, Stephan J.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Sanders, Stephan J.] Yale Univ, Sch Med, Dept Genet, New Haven, CT USA.
   [Goldberg, Arthur P.; Reichert, Jennifer; Reichenberg, Abraham; Buxbaum, Joseph D.] Seaver Autism Ctr Res & Treatment, Icahn Sch Med Mt Sinai, New York, NY USA.
   [Goldberg, Arthur P.; Reichert, Jennifer; Sklar, Pamela; Reichenberg, Abraham; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY USA.
   [Goldberg, Arthur P.; Sklar, Pamela] Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY USA.
   [Mahajan, Milind; Manaa, Dina; Sklar, Pamela; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA.
   [Pawitan, Yudi; Sandin, Sven; Svantesson, Oscar; Hultman, Christina M.] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Ripke, Stephan] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA USA.
   [Sklar, Pamela; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA.
   [Sklar, Pamela] Icahn Sch Med Mt Sinai, Div Psychiat Gen, New York, NY USA.
   [Reichenberg, Abraham] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY USA.
   [Roeder, Kathryn] Carnegie Mellon Univ, Ray & Stephanie Lane Ctr Computat Biol, Pittsburgh, PA USA.
   [Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY USA.
   [Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY USA.
RP Roeder, K (reprint author), Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA.
EM roeder@stat.cmu.edu; joseph.buxbaum@mssm.edu
FU National Institute of Mental Health (NIMH) [MH057881, MH097849]; NIMH
   [MH095034, MH077139]; US NIH [HD055751, HD055782, HD055784, HD35465,
   MH52708, MH55284, MH57881, MH061009, MH06359, MH066673, MH080647,
   MH081754, MH66766, NS026630, NSO42165, NSO49261]; Canadian Institutes
   for Health Research (CIHR); Assistance Publique-Hopitaux de Paris,
   France; Autism Speaks, UK; Canada Foundation for Innovation/Ontario
   Innovation Trust; Deutsche Forschungsgemeinschaft, Germany [Po
   255/17-4]; European Community's Sixth Framework Programme AUTISM MOLGEN;
   Fundacao Calouste Gulbenkian, Portugal; Fondation de France; Fondation
   FondaMental, France; Fondation Orange, France; Fondation pour la
   Recherche Medicale, France; Fundacao pars a Ciencia e Tecnologia,
   Portugal; Hospital for Sick Children Foundation; University of Toronto,
   Canada; INSERM, France; Institut Pasteur, France; Italian Ministry of
   Health [181]; John P. Hussman Foundation, USA; McLaughlin Centre,
   Canada; Netherlands Organization for Scientific Research [Rubicon
   825.06.031]; Royal Netherlands Academy of Arts and Sciences
   [TMF/DA/5801]; Ontario Ministry of Research and Innovation, Canada;
   Seaver Foundation, USA; Swedish Science Council; Centre for Applied
   Genomics, Canada; Utah Autism Foundation, USA; Wellcome Trust, UK
   [075491/Z/04]; Division of Aging Biology and the Division of Geriatrics
   and Clinical Gerontology, National Institute on Aging
FX This study was supported by National Institute of Mental Health (NIMH)
   grants MH057881 and MH097849 and also in part through the computational
   resources and staff expertise provided by the Scientific Computing
   Facility at the Icahn School of Medicine at Mount Sinai. We thank the
   Mount Sinai Genomics Core Facility for carrying out Illumina bead array
   genotyping. We thank D. Cutler, M. Daly and S. Purcell for comments on
   the manuscript and M. Daly and P. Sullivan for facilitating access to
   control samples, collected and genotyped by M. Daly, C.M.H., P.S. and P.
   Sullivan with support from NIMH grants MH095034 and MH077139. We also
   thank the nurses, A.-K. Sundberg and A.-B. Holmgren, for their hard work
   in collecting the samples. AGP: We used data from the Autism Genome
   Project (AGP) Consortium Whole-Genome Association and Copy Number
   Variation Study of over 2,600 parent-offspring trios (database of
   Genotypes and Phenotypes (dbGaP) study phs000267.v4.p2). Funding for AGP
   was provided from the US NIH (HD055751, HD055782, HD055784, HD35465,
   MH52708, MH55284, MH57881, MH061009, MH06359, MH066673, MH080647,
   MH081754, MH66766, NS026630, NSO42165 and NSO49261); the Canadian
   Institutes for Health Research (CIHR); Assistance Publique-Hopitaux de
   Paris, France; Autism Speaks, UK; the Canada Foundation for
   Innovation/Ontario Innovation Trust; grant Po 255/17-4 from Deutsche
   Forschungsgemeinschaft, Germany; the European Community's Sixth
   Framework Programme AUTISM MOLGEN; Fundacao Calouste Gulbenkian,
   Portugal; Fondation de France; Fondation FondaMental, France; Fondation
   Orange, France; Fondation pour la Recherche Medicale, France; Fundacao
   pars a Ciencia e Tecnologia, Portugal; The Hospital for Sick Children
   Foundation and the University of Toronto, Canada; INSERM, France;
   Institut Pasteur, France; Convention 181 of 19.10.2001 from the Italian
   Ministry of Health; the John P. Hussman Foundation, USA; the McLaughlin
   Centre, Canada; Rubicon 825.06.031 from the Netherlands Organization for
   Scientific Research; TMF/DA/5801 from the Royal Netherlands Academy of
   Arts and Sciences; the Ontario Ministry of Research and Innovation,
   Canada; the Seaver Foundation, USA; the Swedish Science Council; the
   Centre for Applied Genomics, Canada; the Utah Autism Foundation, USA;
   and Core award 075491/Z/04 from the Wellcome Trust, UK. Genotype and
   phenotype data were obtained from dbGaP, as provided by AGP study
   investigators. HealthABC: These controls were obtained from dbGaP.
   Funding support for the CIDR Visceral Adiposity Study (dbGaP study
   phs000169.v1.p1) was provided through the Division of Aging Biology and
   the Division of Geriatrics and Clinical Gerontology, National Institute
   on Aging. The CIDR Visceral Adiposity Study includes a GWAS funded as
   part of the Division of Aging Biology and the Division of Geriatrics and
   Clinical Gerontology, National Institute on Aging. Assistance with
   phenotype harmonization and genotype cleaning, as well as with general
   study coordination, was provided by Health ABC study investigators. This
   manuscript reflects the views of the authors and does not necessarily
   reflect the opinions or views of the US NIH.
CR Agarwala V, 2013, NAT GENET, V45, P1418, DOI 10.1038/ng.2804
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Consortium TIS, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
   Cross-Disorder Group of the Psychiatric Genomics Consortium, 2013, NAT GENET, V45, P984
   Crossett A, 2013, ANN APPL STAT, V7, P669, DOI 10.1214/12-AOAS598
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Devlin B, 1997, NATURE, V388, P468, DOI 10.1038/41319
   Dickson SP, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000294
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
   Lee SH, 2013, NAT GENET, V45, P984, DOI 10.1038/ng.2711
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   lossifov I., 2012, NEURON, V74, P285
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Lynch M., 1998, GENETICS ANAL QUANTI
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Orozco G, 2010, HUM MOL GENET, V19, pR137, DOI 10.1093/hmg/ddq368
   Pinto D, 2014, AM J HUM GENET, V94, P677, DOI 10.1016/j.ajhg.2014.03.018
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sandin S., 2014, J AM MED AS IN PRESS
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Stefansson H, 2014, NATURE, V505, P361, DOI 10.1038/nature12818
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Wray NR, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000579
   Yang JA, 2011, AM J HUM GENET, V88, P76, DOI 10.1016/j.ajhg.2010.11.011
   Zuk O, 2012, P NATL ACAD SCI USA, V109, P1193, DOI 10.1073/pnas.1119675109
NR 33
TC 29
Z9 30
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
EI 1546-1718
J9 NAT GENET
JI Nature Genet.
PD AUG
PY 2014
VL 46
IS 8
BP 881
EP 885
DI 10.1038/ng.3039
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA AM2TT
UT WOS:000339704400018
PM 25038753
ER

PT J
AU Rimmer, A
   Phan, H
   Mathieson, I
   Iqbal, Z
   Twigg, SRF
   Wilkie, AOM
   McVean, G
   Lunter, G
AF Rimmer, Andy
   Phan, Hang
   Mathieson, Iain
   Iqbal, Zamin
   Twigg, Stephen R. F.
   Wilkie, Andrew O. M.
   McVean, Gil
   Lunter, Gerton
CA WGS500 Consortium
TI Integrating mapping-, assembly- and haplotype-based approaches for
   calling variants in clinical sequencing applications
SO NATURE GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; HIGH-RESOLUTION HLA; POLYMORPHIC GENOMES;
   CIONA-SAVIGNYI; GENERATION; EXOME; FRAMEWORK; ALIGNMENT; DISEASE; AUTISM
AB High-throughput DNA sequencing technology has transformed genetic research and is starting to make an impact on clinical practice. However, analyzing high-throughput sequencing data remains challenging, particularly in clinical settings where accuracy and turnaround times are critical. We present a new approach to this problem, implemented in a software package called Platypus. Platypus achieves high sensitivity and specificity for SNPs, indels and complex polymorphisms by using local de novo assembly to generate candidate variants, followed by local realignment and probabilistic haplotype estimation. It is an order of magnitude faster than existing tools and generates calls from raw aligned read data without preprocessing. We demonstrate the performance of Platypus in clinically relevant experimental designs by comparing with SAMtools and GATK on whole-genome and exome-capture data, by identifying de novo variation in 15 parent-offspring trios with high sensitivity and specificity, and by estimating human leukocyte antigen genotypes directly from variant calls.
C1 [Rimmer, Andy; Phan, Hang; Mathieson, Iain; Iqbal, Zamin; McVean, Gil; Lunter, Gerton] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
   [Twigg, Stephen R. F.; Wilkie, Andrew O. M.] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DU, England.
   [McVean, Gil] Univ Oxford, Dept Stat, Oxford OX1 3TG, England.
RP Lunter, G (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, S Parks Rd, Oxford, England.
EM gerton.lunter@well.ox.ac.uk
FU Biotechnology and Biological Sciences Research Council (BBSRC)
   [BB/I02593X/1]; Wellcome Trust [102731/Z/13/Z, 089250/Z/09/Z,
   090532/Z/09/Z]; National Institute for Health Research (NIHR) Oxford
   Biomedical Research Centre Programme
FX This study was funded by Biotechnology and Biological Sciences Research
   Council (BBSRC) grant BB/I02593X/1 (G.L., G.M., A.R. and H.P.), by
   Wellcome Trust grants 102731/Z/13/Z (A.O.M.W. and S.R.F.T.),
   089250/Z/09/Z (I.M.) and 090532/Z/09/Z (G.M., G.L. and A.R.), and by the
   National Institute for Health Research (NIHR) Oxford Biomedical Research
   Centre Programme. The views expressed are those of the authors and not
   necessarily those of the National Health Service (NHS), NIHR or the UK
   Department of Health.
CR Altshuler DM, 2012, NATURE, V491, P56, DOI 10.1038/nature11632
   Albers CA, 2011, GENOME RES, V21, P961, DOI 10.1101/gr.112326.110
   Averof M, 2000, SCIENCE, V287, P1283, DOI 10.1126/science.287.5456.1283
   Chen JM, 2012, MUTAT RES-REV MUTAT, V750, P52, DOI 10.1016/j.mrrev.2011.10.002
   Conrad DF, 2011, NAT GENET, V43, P712, DOI 10.1038/ng.862
   de Bakker PIW, 2006, NAT GENET, V38, P1166, DOI 10.1038/ng1885
   DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
   Donmez N, 2011, LECT N BIOINFORMAT, V6577, P38, DOI 10.1007/978-3-642-20036-6_5
   Garrison A., 2012, HAPLOTYPE BASED VARI
   Holcomb CL, 2011, TISSUE ANTIGENS, V77, P206, DOI 10.1111/j.1399-0039.2010.01606.x
   Itoh Y, 2005, IMMUNOGENETICS, V57, P717, DOI 10.1007/s00251-005-0048-3
   Kidd JM, 2010, NAT METHODS, V7, P365, DOI 10.1038/NMETH.1451
   Kim JH, 2007, GENOME RES, V17, P1101, DOI 10.1101/gr.5894107
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Ku CS, 2013, J MED GENET, V50, P203, DOI 10.1136/jmedgenet-2013-101519
   Leslie S, 2008, AM J HUM GENET, V82, P48, DOI 10.1016/j.ajhg.2007.09.001
   Li H, 2011, BIOINFORMATICS, V27, P2987, DOI 10.1093/bioinformatics/btr509
   Li H, 2008, GENOME RES, V18, P1851, DOI 10.1101/gr.078212.108
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
   Li RQ, 2009, GENOME RES, V19, P1124, DOI 10.1101/gr.088013.108
   Li RQ, 2008, BIOINFORMATICS, V24, P713, DOI 10.1093/bioinformatics/btn025
   lqbal Z., 2012, NAT GENET, V44, P226
   Lunter G, 2008, GENOME RES, V18, P298, DOI 10.1101/gr.6725608
   Lunter G, 2011, GENOME RES, V21, P936, DOI 10.1101/gr.111120.110
   Martin HC, 2014, HUM MOL GENET, V23, P3200, DOI 10.1093/hmg/ddu030
   McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
   McVey M, 2008, TRENDS GENET, V24, P529, DOI 10.1016/j.tig.2008.08.007
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Montgomery SB, 2013, GENOME RES, V23, P749, DOI 10.1101/gr.148718.112
   Myers E W, 1995, J Comput Biol, V2, P275, DOI 10.1089/cmb.1995.2.275
   O'Rawe J, 2013, GENOME MED, V5, DOI 10.1186/gm432
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pagnamenta AT, 2012, J HUM GENET, V57, P70, DOI 10.1038/jhg.2011.128
   Pevzner P. A., 2001, P NATL ACAD SCI USA, V98, P9748
   Raczy C, 2013, BIOINFORMATICS, V29, P2041, DOI 10.1093/bioinformatics/btt314
   Ruark E, 2013, NATURE, V493, P406, DOI 10.1038/nature11725
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Simpson JT, 2010, BIOINFORMATICS, V26, pi367, DOI 10.1093/bioinformatics/btq217
   Veeramah KR, 2012, AM J HUM GENET, V90, P502, DOI 10.1016/j.ajhg.2012.01.006
   Vinson JP, 2005, GENOME RES, V15, P1127, DOI 10.1101/gr.3722605
   Zerbino DR, 2008, GENOME RES, V18, P821, DOI 10.1101/gr.074492.107
NR 41
TC 7
Z9 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
EI 1546-1718
J9 NAT GENET
JI Nature Genet.
PD AUG
PY 2014
VL 46
IS 8
BP 912
EP 918
DI 10.1038/ng.3036
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA AM2TT
UT WOS:000339704400024
PM 25017105
ER

PT J
AU Escobedo, L
   Ibarra, C
   Hernandez, J
   Alvelais, M
   Tentori, M
AF Escobedo, Lizbeth
   Ibarra, Catalina
   Hernandez, Jehu
   Alvelais, Mariana
   Tentori, Monica
TI Smart objects to support the discrimination training of children with
   autism
SO PERSONAL AND UBIQUITOUS COMPUTING
LA English
DT Article
DE Tangible computing; Smart objects; Assistive technology; Autism;
   Child-computer interaction; Discrimination training
ID INTERVENTIONS
AB Teachers spend considerable amount of time keeping students with autism "on task" giving away prompts and rewards and maintaining a detailed record of students' progress during the object discrimination training. We hypothesize that tangible computing, in particular smart objects, could help teachers cope with the problems faced during the object discrimination training of students with autism. In this paper, we describe design principles for smart objects to support the object discrimination training and present several example prototypes. First, we present the design and implementation of "Things that think" (T3), a smart device that converts traditional objects into smart objects that promote interactivity with a playful and engaging interaction, and are capable of the automatic recording of students' progress. Then, we present four T3 smart objects assembled in a board. The results of a 7-week deployment study of the use of such smart objects in three classrooms of students with autism (n = 25, 7 teachers and 18 students with autism) demonstrate T3 smart objects reduce the workload of teachers, ease the record-keeping and increase its reliability, and reduce students' behavioral problems while improving their cognitive efficacy. We close discussing directions for future work.
C1 [Escobedo, Lizbeth; Ibarra, Catalina] Univ Autonoma Baja California, Ensenada, Baja California, Mexico.
   [Hernandez, Jehu] Softek, Ensenada, Baja California, Mexico.
   [Alvelais, Mariana] Cetys Univ, Mexicali, Baja California, Mexico.
   [Tentori, Monica] Ctr Sci Res & Higher Educ CICESE, Ensenada, Baja California, Mexico.
RP Escobedo, L (reprint author), Univ Autonoma Baja California, Ensenada, Baja California, Mexico.
EM lescobedo@uabc.edu.mx; catalina.ibarra@uabc.edu.mx; jehu.hdez@gmail.com;
   marina.alvelais@cetys.mx; mtentori@cicese.mx
FU Lizbeth Escobedo's CONACYT fellowship; Catalina Ibarra's CONACYT
   fellowships; UCMexus Grant [634-237]; CONACYT Grant [10256]
FX We thank to Pasitos A. C. for their support. This work was funded
   through Lizbeth Escobedo's and Catalina Ibarra's CONACYT fellowships and
   through the UCMexus Grant #634-237 and CONACYT Grant #10256.
CR Antle AN, 2007, P 1 INT C TANG EMB I, P195, DOI 10.1145/1226969.1227010
   Binger C, 2008, PERSPECT AUGMENT ALT, V17, P20, DOI 10.1044/aac17.1.20
   Boyd L, 2013, SOCIAL COMPASS CURRI
   Brave S, 1998, P CHI 1997, P363
   Campbell JM, 2003, RES DEV DISABIL, V24, P120, DOI 10.1016/S0891-4222(03)00014-3
   Cohen M, 2007, VISUAL SUPPORTS PEOP
   Cramer M., 2011, P CHI 2011, P1
   Dautenhahn K, 2004, PRAGMAT COGN, V12, P1, DOI DOI 10.1075/PC.12.1.03DAU
   Escobedo L., 2012, P 2012 ACM ANN C HUM, P2589, DOI DOI 10.1145/2207676.2208649
   Hayes GR, 2004, LECT NOTES COMPUT SC, V3205, P161
   Hayes GR, 2010, PERS UBIQUIT COMPUT, V14, P663, DOI 10.1007/s00779-010-0294-8
   Hayes GR, 2008, CHI 2008: 26TH ANNUAL CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS VOLS 1 AND 2, CONFERENCE PROCEEDINGS, P685
   Hinske Steve, 2008, Proceedings of the 7th ACM Conference on Designing Interactive Systems. DIS 2008, DOI 10.1145/1394445.1394454
   Hirano SH, 2010, CHI2010: PROCEEDINGS OF THE 28TH ANNUAL CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS, VOLS 1-4, P1633
   Keywon C, 2010, P UIST 2010, P379
   Kientz JA, 2005, LECT NOTES COMPUT SC, V3660, P323
   Lopez de Ipina D, 2005, P 3 EUR JOINT S SYST, P213, DOI 10.1145/1107548.1107602
   Piper AM, 2012, P SIGCHI C HUM FACT, P149, DOI DOI 10.1145/2207676.2207698
   Pontual TF, 2010, P IDC10, P190
   Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
   Quintana Eduardo, 2012, Progress in Pattern Recognition, Image Analysis, ComputerVision, and Applications. Proceedings 17th Iberoamerican Congress, CIARP 2012, DOI 10.1007/978-3-642-33275-3_108
   Raffle HS, 2004, P SIGCHI C HUM FACT, P647, DOI 10.1145/985692.985774
   Sitdhisanguan K, 2012, PERS UBIQUIT COMPUT, V16, P143, DOI 10.1007/s00779-011-0382-4
   Tang ST, 2002, CANCER INVEST, V20, P1086, DOI 10.1081/CNV-120005928
   Tentori M, 2006, IEEE INTELL SYST, V21, P55, DOI 10.1109/MIS.2006.118
   Tentori M, 2010, UBICOMP 2010: PROCEEDINGS OF THE 2010 ACM CONFERENCE ON UBIQUITOUS COMPUTING, P51
   Williams G, 2005, J APPL BEHAV ANAL, V38, P555, DOI 10.1901/jaba.2005.65-04
   Zuckerman O., 2005, P SIGCHI C HUM FACT, P859, DOI 10.1145/1054972.1055093
NR 28
TC 0
Z9 0
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 1617-4909
EI 1617-4917
J9 PERS UBIQUIT COMPUT
JI Pers. Ubiquitous Comput.
PD AUG
PY 2014
VL 18
IS 6
SI SI
BP 1485
EP 1497
DI 10.1007/s00779-013-0750-3
PG 13
WC Computer Science, Information Systems; Telecommunications
SC Computer Science; Telecommunications
GA AM5IW
UT WOS:000339891900018
ER

PT J
AU Halldner, L
   Tillander, A
   Lundholm, C
   Boman, M
   Langstrom, N
   Larsson, H
   Lichtenstein, P
AF Halldner, Linda
   Tillander, Annika
   Lundholm, Cecilia
   Boman, Marcus
   Langstrom, Niklas
   Larsson, Henrik
   Lichtenstein, Paul
TI Relative immaturity and ADHD: findings from nationwide registers,
   parent- and self-reports
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE ADHD; child development; pharmacotherapy; epidemiological studies
ID DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
   DISORDER; TELEPHONE INTERVIEW; AUTISM-TICS; A-TAC; AGE; BIRTH;
   CHILDHOOD; DIAGNOSIS; CHILDREN
AB Background: We addressed if immaturity relative to peers reflected in birth month increases the likelihood of ADHD diagnosis and treatment. Methods: We linked nationwide Patient and Prescribed Drug Registers and used prospective cohort and nested case-control designs to study 6-69 year-old individuals in Sweden from July 2005 to December 2009 (Cohort 1). Cohort 1 included 56,263 individuals diagnosed with ADHD or ever used prescribed ADHD-specific medication. Complementary population-representative cohorts provided DSM-IV ADHD symptom ratings; parent-reported for 10,760 9-year-old twins born 1995-2000 from the CATSS study (Cohort 2) and self-reported for 6,970 adult twins age 20-47 years born 1959-1970 from the STAGE study (Cohort 3). We calculated odds ratios (OR:s) for ADHD across age for individuals born in November/December compared to January/February (Cohort 1). ADHD symptoms in Cohorts 2 and 3 were studied as a function of calendar birth month. Results: ADHD diagnoses and medication treatment were both significantly more common in individuals born in November/December versus January/February; peaking at ages 6 (OR: 1.8; 95% CI: 1.5-2.2) and 7 years (OR: 1.6; 95% CI: 1.3-1.8) in the Patient and Prescribed Drug Registers, respectively. We found no corresponding differences in parent-or self-reported ADHD symptoms by calendar birth month. Conclusion: Relative immaturity compared to class mates might contribute to ADHD diagnosis and pharmacotherapy despite absence of parallel findings in reported ADHD symptom loads by relative immaturity. Increased clinical awareness of this phenomenon may be warranted to decrease risk for imprecise diagnostics and treatment. We speculate that flexibility regarding age at school start according to individual maturity could reduce developmentally inappropriate demands on children and improve the precision of ADHD diagnostic practice and pharmacological treatment.
C1 [Halldner, Linda; Tillander, Annika; Lundholm, Cecilia; Boman, Marcus; Langstrom, Niklas; Larsson, Henrik; Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-11330 Stockholm, Sweden.
   [Halldner, Linda] Karolinska Inst, Karolinska Inst Ctr Neurodev Disorders KIND, SE-11330 Stockholm, Sweden.
RP Halldner, L (reprint author), Karolinska Inst, CAP, Barn & Ungdomspsykiatriskt Forskningsctr, Gavlegatan 22B,Plan 8, SE-11330 Stockholm, Sweden.
EM linda.halldner@ki.se
FU Swedish Research Council [2010-3184]; Karolinska Institutet Center of
   Neurodevelopmental Disorders (KIND)
FX This study was supported in part from Swedish Research Council
   (2010-3184) and Karolinska Institutet Center of Neurodevelopmental
   Disorders (KIND). The authors declare that they have no potential or
   competing conflicts of interest.
CR Abel EL, 2005, SOC BIOL, V52, P47
   Adler LA, 2002, J CLIN PSYCHIAT, V63, P29
   Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
   Atladottir HO, 2007, EPIDEMIOLOGY, V18, P240, DOI 10.1097/01.ede.0000254064.92806.13
   Biederman J, 2006, J CLIN PSYCHIAT, V67, P524
   Biederman J, 2014, J ATTEN DISORD, V18, P179, DOI 10.1177/1087054712445061
   Brookes KJ, 2008, AM J MED GENET B, V147B, P94, DOI 10.1002/ajmg.b.30562
   Chang Z, 2013, JAMA PSYCHIAT, V70, P311, DOI 10.1001/jamapsychiatry.2013.287
   Elder TE, 2010, J HEALTH ECON, V29, P641, DOI 10.1016/j.jhealeco.2010.06.003
   Evans WN, 2010, J HEALTH ECON, V29, P657, DOI 10.1016/j.jhealeco.2010.07.005
   Faraone SV, 2006, PSYCHOL MED, V36, P159, DOI 10.1017/S003329170500471X
   Forsberg L., 2009, KVALITET INNEHALL PA
   Friedrichs B, 2012, J ATTEN DISORD, V16, P13, DOI 10.1177/1087054710376909
   Hansson SL, 2005, BRIT J PSYCHIAT, V187, P262, DOI 10.1192/bjp.187.3.262
   Larson T, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-1
   Larsson H, 2006, J AM ACAD CHILD PSY, V45, P973, DOI 10.1097/01.chi.0000222787.57100.d8
   Larsson H, 2013, PSYCHOL MED, V43, P197, DOI 10.1017/S0033291712001067
   Lemez S., 2013, SCANDINAVIAN J MED S, DOI [10.1111/sms.12127, DOI 10.1111/SMS.12127.]
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lichtenstein P, 2006, TWIN RES HUM GENET, V9, P875, DOI 10.1375/183242706779462444
   LIEDERMAN J, 1994, J CLIN EXP NEUROPSYC, V16, P754, DOI 10.1080/01688639408402689
   Ludvigsson JF, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-450
   Matte Breno, 2012, Atten Defic Hyperact Disord, V4, P53, DOI 10.1007/s12402-012-0077-3
   McAlonan GM, 2009, BRIT J PSYCHIAT, V194, P123, DOI 10.1192/bjp.bp.108.051359
   Mick E, 1996, J AM ACAD CHILD PSY, V35, P1470, DOI 10.1097/00004583-199611000-00015
   Morrow RL, 2012, CAN MED ASSOC J, V184, P755, DOI 10.1503/cmaj.111619
   Shaw P, 2007, P NATL ACAD SCI USA, V104, P19649, DOI 10.1073/pnas.0707741104
   Shaw P, 2011, AM J PSYCHIAT, V168, P143, DOI 10.1176/appi.ajp.2010.10030385
   Steffensson B, 1999, INT J BEHAV DEV, V23, P357
   Thompson AH, 1999, CAN J PSYCHIAT, V44, P82
   Torrey EF, 1997, SCHIZOPHR RES, V28, P1, DOI 10.1016/S0920-9964(97)00092-3
   Turnnidge J, 2014, SCAND J MED SCI SPOR, V24, P461, DOI 10.1111/sms.12002
   Wettermark B, 2007, PHARMACOEPIDEM DR S, V16, P726, DOI 10.1002/pds.1294
   Zetterqvist J, 2013, ACTA PSYCHIAT SCAND, V128, P70, DOI 10.1111/acps.12004
   Zoega H, 2012, PEDIATRICS, V130, P1012, DOI 10.1542/peds.2012-0689
   Zoega H, 2011, ACTA PSYCHIAT SCAND, V123, P360, DOI 10.1111/j.1600-0447.2010.01607.x
NR 36
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD AUG
PY 2014
VL 55
IS 8
BP 897
EP 904
DI 10.1111/jcpp.12229
PG 8
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AL8JO
UT WOS:000339384700007
PM 24673585
ER

PT J
AU Corbett, BA
   Swain, DM
   Newsom, C
   Wang, L
   Song, Y
   Edgerton, D
AF Corbett, Blythe A.
   Swain, Deanna M.
   Newsom, Cassandra
   Wang, Lily
   Song, Yanna
   Edgerton, Dale
TI Biobehavioral profiles of arousal and social motivation in autism
   spectrum disorders
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; cortisol; play; stress; social; interaction; behavior
ID SALIVARY CORTISOL; SQUIRREL-MONKEYS; PUBERTAL STATUS; CHILDREN; STRESS;
   PLAY; SKILLS; COMMUNICATION; VALIDITY; INTERVENTIONS
AB Background: Children with autism spectrum disorder (ASD) are impaired in social communication and interaction with peers, which may reflect diminished social motivation. Many children with ASD show enhanced stress when playing with other children. This study investigated social and stress profiles of children with ASD during play. Methods: We utilized a peer interaction paradigm in a natural playground setting with 66 unmedicated, prepubertal, children aged 8-12 years [38 with ASD, 28 with typical development (TD)]. Salivary cortisol was collected before and after a 20-min playground interaction that was divided into periods of free and solicited play facilitated by a confederate child. Statistical analyses included Wilcoxon rank-sum tests, mixed effects models, and Spearman correlations to assess the between-group differences in social and stress functioning, identify stress responders, and explore associations between variables, respectively. Results: There were no differences between the groups during unsolicited free play; however, during solicited play by the confederate, significant differences emerged such that children with ASD engaged in fewer verbal interactions and more self-play than the TD group. Regarding physiological arousal, children with ASD as a group showed relatively higher cortisol in response to social play; however, there was a broad range of responses. Moreover, those with the highest cortisol levels engaged in less social communication. Conclusions: The social interaction of children with ASD can be facilitated by peer solicitation; however, it may be accompanied by increased stress. The children with ASD that have the highest level of cortisol show less social motivation; yet, it is unclear if it reflects an underlying state of heightened arousal or enhanced reactivity to social engagement, or both.
C1 [Corbett, Blythe A.; Newsom, Cassandra] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA.
   [Corbett, Blythe A.] Vanderbilt Univ, Dept Psychol, Nashville, TN 37203 USA.
   [Corbett, Blythe A.; Swain, Deanna M.; Newsom, Cassandra; Wang, Lily] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
   [Wang, Lily; Song, Yanna] Vanderbilt Univ, Dept Biostat, Nashville, TN 37203 USA.
   [Edgerton, Dale] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37203 USA.
RP Corbett, BA (reprint author), Vanderbilt Univ, PMB 40,230 Appleton Pl, Nashville, TN 37203 USA.
EM blythe.corbett@vanderbilt.edu
FU National Institute of Mental Health [R01 MH085717]; National Institute
   of Child Development Grant [P30 HD15052]; NIH [DK059637, DK020593]
FX The study was funded by the National Institute of Mental Health R01
   MH085717 awarded to Blythe Corbett and a National Institute of Child
   Development Grant P30 HD15052 to Vanderbilt Kennedy Center (VKC). The
   authors thank Eric Allen (VUMC Hormone Assay and Analytical Services
   Core, supported by NIH grants DK059637 and DK020593) for validation and
   completion of the cortisol assays. The authors have declared that they
   have no potential or competing conflicts of interest.
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
   APA, 2000, DIAGN STAT MAN MENT
   Bandura A., 1986, SOCIAL FDN THOUGHT A
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
   Boucher J, 2003, AUTISM, V7, P339, DOI 10.1177/1362361303007004001
   BROOKSGUNN J, 1987, CHILD DEV, V58, P829, DOI 10.1111/j.1467-8624.1987.tb01423.x
   Canivez GL, 2009, SCHOOL PSYCHOL QUART, V24, P252, DOI 10.1037/a0018030
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
   Corbett BA, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-13
   Corbett BA, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-13
   Corbett BA, 2011, J AUTISM DEV DISORD, V41, P505, DOI 10.1007/s10803-010-1064-1
   Corbett BA, 2014, AUTISM RES, V7, P4, DOI 10.1002/aur.1341
   Corbett BA, 2008, J PSYCHIATR NEUROSCI, V33, P227
   Daluwatte C., 2012, J AUTISM DEV DISORD, V43, P1910, DOI DOI 10.1007/S10803-012-1741-3
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   DiSalvo C., 2002, FOCUS AUTISM OTHER D, V17, P198, DOI DOI 10.1177/10883576020170040201
   Frost J. L., 1997, MULTIPLE PERSPECTIVE
   KIRSCHBAUM C, 1989, NEUROPSYCHOBIOLOGY, V22, P150, DOI 10.1159/000118611
   Hennessey J. W., 1979, STRESS AROUSAL PITUI, V8
   Herman JP, 1997, TRENDS NEUROSCI, V20, P78, DOI 10.1016/S0166-2236(96)10069-2
   Honey E, 2007, J AUTISM DEV DISORD, V37, P1107, DOI 10.1007/s10803-006-0253-4
   Humphrey N, 2011, AUTISM, V15, P397, DOI 10.1177/1362361310387804
   HUTT C, 1966, NATURE, V209, P1371, DOI 10.1038/2091371a0
   Kanner L, 1943, NERV CHILD, V2, P217
   Kasari C, 2012, J CHILD PSYCHOL PSYC, V53, P431, DOI 10.1111/j.1469-7610.2011.02493.x
   Knott F, 2006, AUTISM, V10, P609, DOI 10.1177/1362361306068510
   Krasny L, 2003, CHILD ADOL PSYCH CL, V12, P107, DOI 10.1016/S1056-4993(02)00051-2
   Kudielka BM, 2003, PSYCHOSOM MED, V65, P313, DOI 10.1097/01.PSY.0000058374.50240.BF
   Lanni KE, 2012, AUTISM, V16, P123, DOI 10.1177/1362361311425916
   Lopata C, 2008, J AUTISM DEV DISORD, V38, P1866, DOI 10.1007/s10803-008-0575-5
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lyons D., 1990, AM J PRIMATOL, V20, P209
   LYONS DM, 1992, J COMP PSYCHOL, V106, P323, DOI 10.1037/0735-7036.106.4.323
   Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
   MASON JW, 1968, PSYCHOSOM MED, V30, P576
   Mason WA, 1993, PRIMATE SOCIAL CONFL, P205
   MENDOZA SP, 1989, PHYSIOL BEHAV, V46, P597, DOI 10.1016/0031-9384(89)90338-7
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Nakagawa S, 2007, BIOL REV, V82, P591, DOI 10.1111/j.1469-185X.2007.00027.x
   Noldus, 2008, OBS XT, V10.5
   ODOM SL, 1984, AM J ORTHOPSYCHIAT, V54, P544
   Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
   Paul R, 2008, CHILD ADOL PSYCH CL, V17, P835, DOI 10.1016/j.chc.2008.06.011
   Pellegrini AD, 1998, CHILD DEV, V69, P577, DOI 10.1111/j.1467-8624.1998.tb06226.x
   PETERSEN AC, 1988, J YOUTH ADOLESCENCE, V17, P117, DOI 10.1007/BF01537962
   Piaget J, 1969, PSYCHOL CHILD
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schupp CW, 2013, J AUTISM DEV DISORD, V43, P2405, DOI 10.1007/s10803-013-1790-2
   Tanta KJ, 2005, AM J OCCUP THER, V59, P437
   Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
   Wechsler D, 1999, WECHSLER ABBREVIATED
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Yerkes RM, 1908, J COMP NEUROL PSYCHO, V18, P459, DOI 10.1002/cne.920180503
   Yuill N, 2007, J AUTISM DEV DISORD, V37, P1192, DOI 10.1007/s10803-006-0241-8
NR 58
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD AUG
PY 2014
VL 55
IS 8
BP 924
EP 934
DI 10.1111/jcpp.12184
PG 11
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AL8JO
UT WOS:000339384700010
PM 24329926
ER

PT J
AU Ausderau, KK
   Furlong, M
   Sideris, J
   Bulluck, J
   Little, LM
   Watson, LR
   Boyd, BA
   Belger, A
   Dickie, VA
   Baranek, GT
AF Ausderau, Karla K.
   Furlong, Melissa
   Sideris, John
   Bulluck, John
   Little, Lauren M.
   Watson, Linda R.
   Boyd, Brian A.
   Belger, Aysenil
   Dickie, Virginia A.
   Baranek, Grace T.
TI Sensory subtypes in children with autism spectrum disorder: latent
   profile transition analysis using a national survey of sensory features
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Children; autism; sensory; latent profile transition analysis; subtypes
ID DEVELOPMENTAL DELAYS; EXPERIENCES QUESTIONNAIRE; TYPICAL DEVELOPMENT;
   ADAPTIVE-BEHAVIOR; OVER-RESPONSIVITY; YOUNG-CHILDREN; PATTERNS;
   INTERVENTIONS; POTENTIALS; PERCEPTION
AB Background: Sensory features are highly prevalent and heterogeneous among children with ASD. There is a need to identify homogenous groups of children with ASD based on sensory features (i.e. sensory subtypes) to inform research and treatment. Methods: Sensory subtypes and their stability over 1 year were identified through latent profile transition analysis (LPTA) among a national sample of children with ASD. Data were collected from caregivers of children with ASD ages 2-12 years at two time points (Time 1 N = 1294; Time 2 N = 884). Results: Four sensory subtypes (Mild; Sensitive-Distressed; Attenuated-Preoccupied; Extreme-Mixed) were identified, which were supported by fit indices from the LPTA as well as current theoretical models that inform clinical practice. The Mild and Extreme-Mixed subtypes reflected quantitatively different sensory profiles, while the Sensitive-Distressed and Attenuated-Preoccupied subtypes reflected qualitatively different profiles. Further, subtypes reflected differential child (i.e. gender, developmental age, chronological age, autism severity) and family (i.e. income, mother's education) characteristics. Ninety-one percent of participants remained stable in their subtypes over 1 year. Conclusions: Characterizing the nature of homogenous sensory subtypes may facilitate assessment and intervention, as well as potentially inform biological mechanisms.
C1 [Ausderau, Karla K.; Furlong, Melissa; Bulluck, John; Little, Lauren M.; Watson, Linda R.; Boyd, Brian A.; Dickie, Virginia A.; Baranek, Grace T.] Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC USA.
   [Ausderau, Karla K.] Univ Wisconsin, Occupat Therapy Program, Dept Kinesiol, Madison, WI 53706 USA.
   [Sideris, John] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC USA.
   [Belger, Aysenil] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
RP Ausderau, KK (reprint author), Univ Wisconsin, Med Sci Ctr 3195, Dept Kinesiol, Occupat Therapy Program, 1300 Univ Ave, Madison, WI 53706 USA.
EM kausderau@wisc.edu
FU National Institute for Child Health and Human Development (ARRA
   Supplement) [A10-0589, R01-HD42168]; Neurodevelopmental Disorders
   Research Center Autism Subject Registry at The University of North
   Carolina at Chapel Hill [P30-HD03110]
FX This research was supported by grants from the National Institute for
   Child Health and Human Development (ARRA Supplement A10-0589;
   R01-HD42168) and The Neurodevelopmental Disorders Research Center Autism
   Subject Registry at The University of North Carolina at Chapel Hill
   (P30-HD03110). The authors thank the families that participated in the
   study as well as the research team at the Sensory Experiences Project.
   They also thank Aaron Thompson at University of Missouri for sharing his
   expertise regarding latent profile transition analysis. They thank the
   Interactive Autism Network (IAN) Project at the Kennedy Krieger
   Institute, Baltimore, Maryland, the University of North Carolina at
   Chapel Hill Research Registry, and the multiple other autism
   organizations who assisted in recruitment. All authors have declared
   that they have no potential or competing conflicts of interest.
CR Allison PD, 2001, MISSING DATA
   American Academy of Pediatrics, 2012, PEDIATRICS, V129, P1186, DOI [10.1542/peds.2012-0876, DOI 10.1542/PEDS.2012-0876]
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Ausderau K., 2013, J AUTISM DEV DISORD, P1
   Baranek G. T., 2009, SENSORY EXPERIENCES
   Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
   Baranek GT, 2013, DEV PSYCHOPATHOL, V25, P307, DOI 10.1017/S0954579412001071
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
   Ben-Sasson A, 2007, AM J OCCUP THER, V61, P584
   Bomba MD, 2004, INT J PSYCHOPHYSIOL, V53, P161, DOI 10.1016/j.ijpsycho.2004.04.001
   Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124
   Collins L. M., 2010, LATENT CLASS LATENT
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7
   Dunn W., 1999, SENSORY PROFILE EXAM
   Gabriels RL, 2008, RES AUTISM SPECT DIS, V2, P660, DOI 10.1016/j.rasd.2008.02.002
   Grizenko Natalie, 2013, J Can Acad Child Adolesc Psychiatry, V22, P153
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Jeste SS, 2009, J AUTISM DEV DISORD, V39, P495, DOI 10.1007/s10803-008-0652-9
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y
   Larsson H, 2006, J AM ACAD CHILD PSY, V45, P973, DOI 10.1097/01.chi.0000222787.57100.d8
   Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
   Little LM, 2011, AM J OCCUP THER, V65, P207, DOI 10.5014/ajot.2011.000844
   Lo YT, 2001, BIOMETRIKA, V88, P767, DOI 10.1093/biomet/88.3.767
   Macy RJ, 2008, VIOLENCE AGAINST WOM, V14, P1128, DOI 10.1177/1077801208322701
   Marco EJ, 2011, PEDIATR RES, V69, p48R, DOI [10.1203/PDR.0b013e3182130c54, 10.1109/SPL.2011.5782616]
   May-Benson TA, 2010, AM J OCCUP THER, V64, P403, DOI 10.5014/ajot.2010.09071
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Mottron L, 2009, PHILOS T R SOC B, V364, P1385, DOI 10.1098/rstb.2008.0333
   Muthen L. K., 2010, MPLUS USERS GUIDE
   Nagin D, 2005, GROUP BASED MODELING
   Neely-Barnes S, 2010, SOC WORK RES, V34, P114
   Nylund KL, 2007, STRUCT EQU MODELING, V14, P535
   O'Donnell S, 2012, AM J OCCUP THER, V66, P586, DOI 10.5014/ajot.2012.004168
   Pine E, 2006, AUTISM, V10, P344, DOI 10.1177/1362361306064434
   Qualtrics Labs I. s., 2011, QUALTR RES SUIT VERS
   Reynolds S, 2008, J AUTISM DEV DISORD, V38, P516, DOI 10.1007/s10803-007-0418-9
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Schoen SA, 2008, AM J OCCUP THER, V62, P393
   Thompson AM, 2011, J COMMUNITY PSYCHOL, V39, P987, DOI 10.1002/jcop.20485
   Volkmar F., 2014, HDB AUTISM, P378
   Watson LR, 2011, J SPEECH LANG HEAR R, V54, P1562, DOI 10.1044/1092-4388(2011/10-0029)
NR 47
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD AUG
PY 2014
VL 55
IS 8
BP 935
EP 944
DI 10.1111/jcpp.12219
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AL8JO
UT WOS:000339384700011
PM 25039572
ER

PT J
AU Wolff, JJ
   Botteron, KN
   Dager, SR
   Elison, JT
   Estes, AM
   Gu, HB
   Hazlett, HC
   Pandey, J
   Paterson, SJ
   Schultz, RT
   Zwaigenbaum, L
   Piven, J
AF Wolff, Jason J.
   Botteron, Kelly N.
   Dager, Stephen R.
   Elison, Jed T.
   Estes, Annette M.
   Gu, Hongbin
   Hazlett, Heather C.
   Pandey, Juhi
   Paterson, Sarah J.
   Schultz, Robert T.
   Zwaigenbaum, Lonnie
   Piven, Joseph
CA IBIS Network
TI Longitudinal patterns of repetitive behavior in toddlers with autism
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; repetitive behavior; high-risk siblings
ID SPECTRUM DISORDERS; STEREOTYPED MOVEMENTS; YOUNG-CHILDREN; SIBLINGS;
   INFANTS; AGE; INDIVIDUALS; ASSOCIATION; ATTENTION; SAMPLE
AB Background: Recent evidence suggests that restricted and repetitive behaviors may differentiate children who develop autism spectrum disorder (ASD) by late infancy. How these core symptoms manifest early in life, particularly among infants at high risk for the disorder, is not well characterized. Methods: Prospective, longitudinal parent-report data (Repetitive Behavior Scales-Revised) were collected for 190 high-risk toddlers and 60 low-risk controls from 12 to 24 months of age. Forty-one high-risk children were classified with ASD at age 2. Profiles of repetitive behavior were compared between groups using generalized estimating equations. Results: Longitudinal profiles for children diagnosed with ASD differed significantly from high-and low-risk children without the disorder on all measures of repetitive behavior. High-risk toddlers without ASD were intermediate to low risk and ASD positive counterparts. Toddlers with ASD showed significantly higher rates of repetitive behavior across subtypes at the 12-month time point. Repetitive behaviors were significantly correlated with adaptive behavior and socialization scores among children with ASD at 24 months of age, but were largely unrelated to measures of general cognitive ability. Conclusions: These findings suggest that as early as 12 months of age, a broad range of repetitive behaviors are highly elevated in children who go on to develop ASD. While some degree of repetitive behavior is elemental to typical early development, the extent of these behaviors among children who develop ASD appears highly atypical.
C1 [Wolff, Jason J.; Hazlett, Heather C.; Piven, Joseph] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
   [Gu, Hongbin; Hazlett, Heather C.; Piven, Joseph] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
   [Botteron, Kelly N.] Washington Univ, Dept Psychiat, St Louis, MO USA.
   [Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
   [Elison, Jed T.] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
   [Estes, Annette M.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
   [Pandey, Juhi; Paterson, Sarah J.; Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
   [Zwaigenbaum, Lonnie] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.
RP Wolff, JJ (reprint author), Univ N Carolina, Carolina Inst Dev Disabil, CB 3367, Chapel Hill, NC 27599 USA.
EM jason.wolff@cidd.unc.edu
RI Pike, Bruce/K-5562-2014
OI Pike, Bruce/0000-0001-8924-683X
FU NIH [R01-HD055741, HD055741-S1, K01-MN101653, P30-HD03110]; Autism
   Speaks; Simons Foundation; IBIS Network is an NIH
FX This study was supported by grants from NIH (R01-HD055741, HD055741-S1,
   K01-MN101653, & P30-HD03110), Autism Speaks, and the Simons Foundation.
   The authors thank 'The Infant Brain Imaging Study (IBIS) Network'
   families for participating in this research. IBIS Network is an NIH
   funded Autism Center of Excellence project and consists of a consortium
   of seven universities in the United States and Canada. Clinical Sites:
   University of North Carolina: J. Piven (IBIS Network PI), H. C. Hazlett,
   J. C. Chappell; University of Washington: S. Dager, A. Estes, D. Shaw;
   Washington University: K. Botteron, R. McKinstry, J. Constantino, J.
   Pruett; Children's Hospital of Philadelphia: R. Schultz, S. Paterson;
   University of Alberta: L. Zwaigenbaum; Data Coordinating Center:
   Montreal Neurological Institute: A. C. Evans, D. L. Collins, G. B. Pike,
   P. Kostopolous, S. Das; Image Processing Core: University of Utah: G.
   Gerig; University of North Carolina: M. Styner; Statistical Analysis
   Core: University of North Carolina: H. Gu; Genetics Analysis Core:
   University of North Carolina: P. Sullivan, F. Wright. All authors have
   declared that they have no potential or competing conflicts of interest.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Arnott B, 2010, J DEV BEHAV PEDIATR, V31, P223, DOI 10.1097/DBP.0b013e3181d5a2ad
   Barber AB, 2012, J AUTISM DEV DISORD, V42, P2006, DOI 10.1007/s10803-011-1434-3
   Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288
   Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
   Chawarska K, 2013, BIOL PSYCHIAT, V74, P195, DOI 10.1016/j.biopsych.2012.11.022
   Christensen L, 2010, J AUTISM DEV DISORD, V40, P946, DOI 10.1007/s10803-010-0941-y
   Damiano CR, 2013, J AUTISM DEV DISORD, V43, P1326, DOI 10.1007/s10803-012-1681-y
   Ejiri K, 2001, DEVELOPMENTAL SCI, V4, P40, DOI 10.1111/1467-7687.00147
   Elison JT, 2013, AM J PSYCHIAT, V170, P899, DOI 10.1176/appi.ajp.2012.12091150
   Elison JT, 2013, DEVELOPMENTAL SCI, V16, P186, DOI 10.1111/desc.12015
   Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925
   Georgiades S, 2013, JAMA PSYCHIAT, V70, P42, DOI 10.1001/2013.jamapsychiatry.1
   Hollander E, 2003, PSYCHIAT RES, V117, P11, DOI 10.1016/S0165-1781(02)00304-9
   Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
   Kanner L, 1943, NERV CHILD, V2, P217
   Kim SH, 2010, AUTISM RES, V3, P162, DOI 10.1002/aur.142
   Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
   Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x
   Lee S, 2007, J POSIT BEHAV INTERV, V9, P67, DOI 10.1177/10983007070090020401
   Leekam S, 2007, J CHILD PSYCHOL PSYC, V48, P1131, DOI 10.1111/j.1469-7610.2007.01778.x
   Loh A, 2007, J AUTISM DEV DISORD, V37, P25, DOI 10.1007/s10803-006-0333-5
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MASON GJ, 1991, ANIM BEHAV, V41, P1015, DOI 10.1016/S0003-3472(05)80640-2
   Messinger D, 2013, J AM ACAD CHILD PSY, V52, P300, DOI 10.1016/j.jaac.2012.12.011
   Mirenda P, 2010, J AUTISM DEV DISORD, V40, P1521, DOI 10.1007/s10803-010-1012-0
   Morgan L, 2008, J CHILD PSYCHOL PSYC, V49, P826, DOI 10.1111/j.1469-7610.2008.01904.x
   Mullen E, 1995, MULLEN SCALES EARLY
   Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402
   Restivo L, 2005, P NATL ACAD SCI USA, V102, P11557, DOI 10.1073/pnas.0504984102
   Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Szatmari P, 2007, AM J MED GENET B, V144B, P581, DOI 10.1002/ajmg.b.30426
   THELEN E, 1995, AM PSYCHOL, V50, P79, DOI 10.1037//0003-066X.50.2.79
   THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X
   Toth K, 2007, J AUTISM DEV DISORD, V37, P145, DOI 10.1007/s10803-006-0336-2
   Watson LR, 2007, J AUTISM DEV DISORD, V37, P49, DOI 10.1007/s10803-006-0334-4
   Watt N, 2008, J AUTISM DEV DISORD, V38, P1518, DOI 10.1007/s10803-007-0532-8
   Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6
   Wetherby A. M., 2007, REPETITIVE STE UNPUB
   Wolff JJ, 2013, NEUROPSYCHIATRY-LOND, V3, P209, DOI 10.2217/NPY.13.11
   WOLFF PH, 1967, B MENNINGER CLIN, V31, P197
NR 44
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD AUG
PY 2014
VL 55
IS 8
BP 945
EP 953
DI 10.1111/jcpp.12207
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AL8JO
UT WOS:000339384700012
PM 24552513
ER

PT J
AU Godavarthi, SK
   Sharma, A
   Jana, NR
AF Godavarthi, Swetha K.
   Sharma, Ankit
   Jana, Nihar Ranjan
TI Reversal of reduced parvalbumin neurons in hippocampus and amygdala of
   Angelman syndrome model mice by chronic treatment of fluoxetine
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE angelman syndrome; anxiety; chronic stress; fluoxetine; parvalbumin
ID LONG-TERM POTENTIATION; RAT HIPPOCAMPUS; ANTIDEPRESSANT FLUOXETINE;
   POSTNATAL-DEVELOPMENT; MOUSE MODEL; INTERNEURONS; EXPRESSION; ANXIETY;
   DEFICITS; PROTEIN
AB Angelman syndrome (AS) is a neuropsychiatric disorder characterized by autism, intellectual disability and motor disturbances. The disease is primarily caused by the loss of function of maternally inherited UBE3A. Ube3a maternal-deficient mice recapitulates many essential feature of AS. These AS mice have been shown to be under chronic stress and exhibits anxiety-like behaviour because of defective glucocorticoid receptor signalling. Here, we demonstrate that chronic stress in these mice could lead to down-regulation of parvalbumin-positive interneurons in the hippocampus and basolateral amygdala from early post-natal days. Down-regulation of parvalbumin-positive interneurons number could be because of decrease in the expression of parvalbumin in these neurons. We also find that treatment with fluoxetine, a selective serotonin reuptake inhibitor, results in restoration of impaired glucocorticoid signalling, elevated serum corticosterone level, parvalbumin-positive interneurons and anxiety-like behaviours. Our findings suggest that impaired glucocorticod signalling in hippocampus and amygdala of AS mice is critical for the decrease in parvalbumin interneurons number, emergence of anxiety and other behavioural deficits and highlights the importance of fluoxetine in the recovery of these abnormalities.
C1 [Godavarthi, Swetha K.; Sharma, Ankit; Jana, Nihar Ranjan] Natl Brain Res Ctr, Cellular & Mol Neurosci Lab, Manesar, Gurgaon, India.
RP Jana, NR (reprint author), Natl Brain Res Ctr, Cellular & Mol Neurosci Lab, Manesar, Gurgaon, India.
EM nihar@nbrc.ac.in
FU Department of Biotechnology [BT/HRD/34/18/2008]
FX This work was supported by the core grant from the Department of
   Biotechnology to the National Brain Research Centre, Government of
   India. NRJ is a recipient of National Bioscience Award for Career
   Development from Department of Biotechnology (BT/HRD/34/18/2008).
CR Albrecht U, 1997, NAT GENET, V17, P75, DOI 10.1038/ng0997-75
   ALCANTARA S, 1993, ANAT EMBRYOL, V188, P63
   Baudry M, 2012, NEUROBIOL DIS, V47, P210, DOI 10.1016/j.nbd.2012.04.002
   Berdel B, 2000, INT J DEV NEUROSCI, V18, P501, DOI 10.1016/S0736-5748(00)00024-1
   Chen YJ, 2010, P NATL ACAD SCI USA, V107, P21818, DOI 10.1073/pnas.1010669107
   Czeh B, 2005, NEUROPSYCHOPHARMACOL, V30, P67, DOI 10.1038/sj.npp.1300581
   de Groote L, 2007, NEUROSCIENCE, V148, P794, DOI 10.1016/j.neuroscience.2007.06.030
   Ebert MH, 1997, J NEUROPSYCH CLIN N, V9, P75
   Fairbanks JM, 1997, J CHILD ADOL PSYCHOP, V7, P17, DOI 10.1089/cap.1997.7.17
   Farook MF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043030
   Ferdousy F, 2011, NEUROBIOL DIS, V41, P669, DOI 10.1016/j.nbd.2010.12.001
   Fisahn A, 2009, CEREB CORTEX, V19, P612, DOI 10.1093/cercor/bhn107
   Godavarthi SK, 2012, HUM MOL GENET, V21, P1824, DOI 10.1093/hmg/ddr614
   Greer PL, 2010, CELL, V140, P704, DOI 10.1016/j.cell.2010.01.026
   Hale MW, 2010, PROG NEURO-PSYCHOPH, V34, P1285, DOI 10.1016/j.pnpbp.2010.07.012
   Heck DH, 2008, HUM MOL GENET, V17, P2181, DOI 10.1093/hmg/ddn117
   Hensch TK, 2004, ANNU REV NEUROSCI, V27, P549, DOI 10.1146/annurev.neuro.27.070203.144327
   Huang HS, 2013, BEHAV BRAIN RES, V243, P79, DOI 10.1016/j.bbr.2012.12.052
   HUIBREGTSE JM, 1995, P NATL ACAD SCI USA, V92, P5249
   Jana NR, 2012, NEURAL PLAST, DOI 10.1155/2012/710943
   Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6
   Kaphzan H, 2012, BIOL PSYCHIAT, V72, P182, DOI 10.1016/j.biopsych.2012.01.021
   KAWAGUCHI Y, 1987, BRAIN RES, V416, P369, DOI 10.1016/0006-8993(87)90921-8
   Kishino T, 1997, NAT GENET, V15, P70, DOI 10.1038/ng0197-70
   Likhtik E, 2008, NATURE, V454, P642, DOI 10.1038/nature07167
   Maggio N, 2009, J NEUROSCI, V29, P2857, DOI 10.1523/JNEUROSCI.4399-08.2009
   Navailles S, 2010, DEV NEUROSCI-BASEL, V32, P139, DOI 10.1159/000293989
   Nawaz Z, 1999, MOL CELL BIOL, V19, P1182
   Orchinik M, 2001, J NEUROSCI, V21, P330
   Pariante CM, 2003, BRIT J PHARMACOL, V139, P1111, DOI 10.1038/sj.bjp.0705357
   Patz S, 2004, CEREB CORTEX, V14, P342, DOI 10.1093/cercor/bhg132
   Rao SNR, 2010, J BIOL CHEM, V285, P1404, DOI 10.1074/jbc.M109.006312
   Rao SNR, 2010, HUM MOL GENET, V19, P4726, DOI 10.1093/hmg/ddq407
   Ravinder S, 2011, FRONT BEHAV NEUROSCI, V5, DOI 10.3389/fnbeh.2011.00088
   RIBAK CE, 1990, J COMP NEUROL, V300, P449, DOI 10.1002/cne.903000402
   ROSENFELD P, 1993, CELL MOL NEUROBIOL, V13, P295, DOI 10.1007/BF00711575
   Smith J C, 2001, Dev Med Child Neurol, V43, P476
   Surget A, 2011, MOL PSYCHIATR, V16, P1177, DOI 10.1038/mp.2011.48
   Urakawa S, 2013, BMC NEUROSCI, V14, DOI 10.1186/1471-2202-14-13
   Van den Bosch L, 2002, EXP NEUROL, V174, P150, DOI 10.1006/exnr.2001.7858
   Wallace ML, 2012, NEURON, V74, P793, DOI 10.1016/j.neuron.2012.03.036
   Williams CA, 2010, GENET MED, V12, P385, DOI 10.1097/GIM.0b013e3181def138
   Yamasaki K., 2003, Human Molecular Genetics, V12, P837, DOI 10.1093/hmg/ddg106
   Yau JLW, 2004, MOL BRAIN RES, V129, P189, DOI 10.1016/j.molbrainres.2004.06.033
NR 44
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD AUG
PY 2014
VL 130
IS 3
BP 444
EP 454
DI 10.1111/jnc.12726
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AL9RU
UT WOS:000339479200011
PM 24678582
ER

PT J
AU Doers, ME
   Musser, MT
   Nichol, R
   Berndt, ER
   Baker, M
   Gomez, TM
   Zhang, SC
   Abbeduto, L
   Bhattacharyya, A
AF Doers, Matthew E.
   Musser, Michael T.
   Nichol, Robert
   Berndt, Erich R.
   Baker, Mei
   Gomez, Timothy M.
   Zhang, Su-Chun
   Abbeduto, Leonard
   Bhattacharyya, Anita
TI iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in
   Initial Neurite Outgrowth
SO STEM CELLS AND DEVELOPMENT
LA English
DT Article
ID FRAGILE-X-SYNDROME; PLURIPOTENT STEM-CELLS; MENTAL-RETARDATION PROTEIN;
   FMR1 MESSENGER-RNA; DIRECTED DIFFERENTIATION; NEURAL DIFFERENTIATION;
   CGG EXPANSIONS; FULL MUTATION; GENE; EXPRESSION
AB Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5 -untranslated region of the FMR1 gene on the X chromosome leading to the loss of expression of the fragile X mental retardation protein (FMRP). The cause of FXS has been known for over 20 years, yet the full molecular and cellular consequences of this mutation remain unclear. Although mouse and fly models have provided significant understanding of this disorder and its effects on the central nervous system, insight from human studies is limited. We have created human induced pluripotent stem cell (iPSC) lines from fibroblasts obtained from individuals with FXS to enable in vitro modeling of the human disease. Three young boys with FXS who came from a well-characterized cohort representative of the range of affectedness typical for the syndrome were recruited to aid in linking cellular and behavioral phenotypes. The FMR1 mutation is preserved during the reprogramming of patient fibroblasts to iPSCs. Mosaicism of the CGG repeat length in one of the patient's fibroblasts allowed for the generation of isogenic lines with differing CGG repeat lengths from the same patient. FXS forebrain neurons were differentiated from these iPSCs and display defective neurite initiation and extension. These cells provide a well-characterized resource to examine potential neuronal deficits caused by FXS as well as the function of FMRP in human neurons.
C1 [Doers, Matthew E.; Musser, Michael T.; Berndt, Erich R.; Zhang, Su-Chun; Abbeduto, Leonard; Bhattacharyya, Anita] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
   [Nichol, Robert; Gomez, Timothy M.; Zhang, Su-Chun] Univ Wisconsin, Sch Med & Publ Hlth, Neurosci Training Program, Madison, WI 53705 USA.
   [Nichol, Robert; Gomez, Timothy M.; Zhang, Su-Chun] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurosci, Madison, WI 53705 USA.
   [Baker, Mei] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53705 USA.
   [Baker, Mei] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA.
   [Baker, Mei] Newborn Screening Lab, Madison, WI USA.
   [Zhang, Su-Chun] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurol, Madison, WI 53705 USA.
   [Abbeduto, Leonard] Univ Calif Davis, Dept Psychiat & Behav Sci, MIND Inst, Sacramento, CA 95817 USA.
RP Bhattacharyya, A (reprint author), Univ Wisconsin, Waisman Ctr 623, 1500 Highland Ave, Madison, WI 53705 USA.
EM bhattacharyy@waisman.wisc.edu
FU National Institutes of Health National Center for Advancing
   Translational Sciences (NCATS) [UL1TR000427]; FRAXA Research Foundation
   Grant; NIH [R01 HD054764, R01 NS41564]; Heckrodt Family Foundation
   Grant; NIH-NICHD [P30 HD03352]
FX The authors thank Xinyu Zhao and members of the Waisman Center Fragile X
   Focus Group for helpful discussions. We thank Xiaoqing Zhang, Jianfeng
   Lu, and Yingnan Yin in the Waisman Center iPSC core for reprogramming
   services. We also thank Jason P. Weick for assistance with neuronal
   differentiation and Anne Antkins and Rebecca Reese for technical
   assistance. The project was supported by grant UL1TR000427 to the
   University of Wisconsin Institute for Clinical and Translational
   Research by the National Institutes of Health National Center for
   Advancing Translational Sciences (NCATS) (A.B.), a FRAXA Research
   Foundation Grant (A.B.), NIH R01 HD054764 (L.A.) and NIH R01 NS41564
   (T.M.G.). This work was also funded in part by a Heckrodt Family
   Foundation Grant to the Waisman Center and a core grant from the
   NIH-NICHD (P30 HD03352).
CR ABITBOL M, 1993, NAT GENET, V4, P147, DOI 10.1038/ng0693-147
   Antar LN, 2006, MOL CELL NEUROSCI, V32, P37, DOI 10.1016/j.mcn.2006.02.001
   ASHLEY CT, 1993, SCIENCE, V262, P563, DOI 10.1126/science.7692601
   Bakker CE, 2003, CYTOGENET GENOME RES, V100, P111, DOI 10.1159/000072845
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Bhattacharyya A, 2008, STEM CELLS DEV, V17, P107, DOI 10.1089/scd.2007.0073
   Bolduc FV, 2008, NAT NEUROSCI, V11, P1143, DOI 10.1038/nn.2175
   Brouwer JR, 2007, EXP CELL RES, V313, P244, DOI 10.1016/j.yexcr.2006.10.002
   Brown V, 2001, CELL, V107, P477, DOI 10.1016/S0092-8674(01)00568-2
   Castren M, 2005, P NATL ACAD SCI USA, V102, P17834, DOI 10.1073/pnas.0508995102
   Chambers SM, 2009, NAT BIOTECHNOL, V27, P275, DOI 10.1038/nbt.1529
   Coffee B, 2002, AM J HUM GENET, V71, P923, DOI 10.1086/342931
   Coffee B, 1999, NAT GENET, V22, P98
   Darnell JC, 2011, CURR OPIN GENET DEV, V21, P465, DOI 10.1016/j.gde.2011.05.002
   DENT EW, 1992, J NEUROBIOL, V23, P1037, DOI 10.1002/neu.480230809
   DEVYS D, 1993, NAT GENET, V4, P335, DOI 10.1038/ng0893-335
   Dictenberg JB, 2008, DEV CELL, V14, P926, DOI 10.1016/j.devcel.2008.04.003
   Dockendorff TC, 2002, NEURON, V34, P973, DOI 10.1016/S0896-6273(02)00724-9
   Eberhart DE, 1996, HUM MOL GENET, V5, P1083, DOI 10.1093/hmg/5.8.1083
   Eiges R, 2007, CELL STEM CELL, V1, P568, DOI 10.1016/j.stem.2007.09.001
   Feng Y, 1997, J NEUROSCI, V17, P1539
   Gore A, 2011, NATURE, V471, P63, DOI 10.1038/nature09805
   Grossman AW, 2006, BRAIN RES, V1084, P158, DOI 10.1016/j.brainres.2006.02.044
   Hagerman RJ, 2002, FRAGILE X SYNDROME
   HAGERMAN RJ, 1994, AM J MED GENET, V51, P298, DOI 10.1002/ajmg.1320510404
   Hagerman RJ, 2005, CURR OPIN PSYCHIATR, V18, P490, DOI 10.1097/01.yco.0000179485.39520.b0
   HINDS HL, 1993, NAT GENET, V3, P36, DOI 10.1038/ng0193-36
   HINTON VJ, 1991, AM J MED GENET, V41, P289, DOI 10.1002/ajmg.1320410306
   Hu BY, 2010, METHODS MOL BIOL, V636, P123, DOI 10.1007/978-1-60761-691-7_8
   Hu BY, 2010, P NATL ACAD SCI USA, V107, P4335, DOI 10.1073/pnas.0910012107
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Irwin SA, 2001, AM J MED GENET, V98, P161, DOI 10.1002/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B
   Jin P, 2000, HUM MOL GENET, V9, P901, DOI 10.1093/hmg/9.6.901
   Johnson MA, 2007, J NEUROSCI, V27, P3069, DOI 10.1523/JNEUROSCI.4562-06.2007
   Kunst CB, 1997, J MED GENET, V34, P627, DOI 10.1136/jmg.34.8.627
   Liu HS, 2011, CELL MOL LIFE SCI, V68, P3995, DOI 10.1007/s00018-011-0770-y
   LOESCH DZ, 1993, AM J HUM GENET, V53, P1064
   Loesch DZ, 2012, CLIN GENET, V82, P88, DOI 10.1111/j.1399-0004.2011.01675.x
   Loesch DZ, 2004, MENT RETARD DEV D R, V10, P31, DOI 10.1002/mrdd.20006
   Maenner MJ, 2013, AM J MED GENET B, V162B, P466, DOI 10.1002/ajmg.b.32176
   Martins-Taylor K, 2011, NAT BIOTECHNOL, V29, P488, DOI 10.1038/nbt.1890
   McConnell MJ, 2013, SCIENCE, V342, P632, DOI 10.1126/science.1243472
   Miyashiro KY, 2003, NEURON, V37, P417, DOI 10.1016/S0896-6273(03)00034-5
   Morales J, 2002, NEURON, V34, P961, DOI 10.1016/S0896-6273(02)00731-6
   NOLIN SL, 1994, AM J MED GENET, V51, P509, DOI 10.1002/ajmg.1320510444
   Pan LY, 2004, CURR BIOL, V14, P1863, DOI 10.1016/j.cub.2004.09.085
   Pankratz MT, 2007, STEM CELLS, V25, P1511, DOI 10.1634/stemcells.2006-0707
   Park IH, 2008, CELL, V134, P877, DOI 10.1016/j.cell.2008.07.041
   PIERETTI M, 1991, CELL, V66, P817, DOI 10.1016/0092-8674(91)90125-I
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Seltzer MM, 2012, AM J MED GENET B, V159B, P589, DOI 10.1002/ajmg.b.32065
   Sheridan SD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026203
   Shi YC, 2012, NAT PROTOC, V7, P1836, DOI 10.1038/nprot.2012.116
   Sidorov MS, 2013, MOL BRAIN, V6, DOI 10.1186/1756-6606-6-15
   Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
   Tassone F, 2007, RNA, V13, P555, DOI 10.1261/rna.280807
   Tucker B, 2006, HUM MOL GENET, V15, P3446, DOI 10.1093/hmg/ddl422
   Urbach A, 2010, CELL STEM CELL, V6, P407, DOI 10.1016/j.stem.2010.04.005
   VERHEIJ C, 1993, NATURE, V363, P722, DOI 10.1038/363722a0
   VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
   Wang T, 2013, PROTEIN CELL, V4, P820, DOI 10.1007/s13238-013-3074-1
   WISNIEWSKI KE, 1991, AM J MED GENET, V38, P476, DOI 10.1002/ajmg.1320380267
   Yu JY, 2007, SCIENCE, V318, P1917, DOI 10.1126/science.1172482
   Zhang SC, 2006, BRAIN PATHOL, V16, P132, DOI 10.1111/j.1750-3639.2006.00008.x
   Zhang YQ, 2001, CELL, V107, P591, DOI 10.1016/S0092-8674(01)00589-X
NR 65
TC 1
Z9 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1547-3287
EI 1557-8534
J9 STEM CELLS DEV
JI Stem Cells Dev.
PD AUG 1
PY 2014
VL 23
IS 15
BP 1777
EP 1787
DI 10.1089/scd.2014.0030
PG 11
WC Cell & Tissue Engineering; Hematology; Medicine, Research &
   Experimental; Transplantation
SC Cell Biology; Hematology; Research & Experimental Medicine;
   Transplantation
GA AL7MK
UT WOS:000339317700007
PM 24654675
ER

PT J
AU Ramisch, JL
   Onaga, E
   Oh, SM
AF Ramisch, Julie L.
   Onaga, Esther
   Oh, Su Min
TI Keeping a Sound Marriage: How Couples with Children with Autism Spectrum
   Disorders Maintain Their Marriages
SO JOURNAL OF CHILD AND FAMILY STUDIES
LA English
DT Article
DE Autism; Communication; Concept mapping; Couples; Marriage
ID MARITAL SATISFACTION SCALE; COPING BEHAVIORS; PARENTS; FAMILIES; STRESS;
   DISABILITIES; EXPERIENCES; ADJUSTMENT; IMPACT; WELL
AB This study focused on strengths and variables that contribute to marital successes for couples with children with autism spectrum disorders (in this article, referred to as "autism"). Particularly, the purpose of this study was to examine what husbands and wives with children with autism in contrast to couples with children who are typically developing identify as helpful to maintaining their marriages. Concept mapping methodology was used for this research study. Couples with children with autism and couples with children who are typically developing participated in telephone interviews and then grouped and rated the statements generated from their interviews. Groupings were translated into pictorial maps showing relationships and patterns. Couples with children with autism shared common perceptions about factors that help to keep their marriages strong: communication and shared foundational ideas about marriage. Communication was a cluster for all groups of husbands and wives. Only mothers of children with autism identified time for self-care as a distinct cluster.
C1 [Ramisch, Julie L.] No Illinois Univ, Sch Family Consumer & Nutr Sci, De Kalb, IL 60115 USA.
   [Onaga, Esther] Michigan State Univ, E Lansing, MI 48824 USA.
   [Oh, Su Min] Michigan Dept Community Hlth, Lansing, MI USA.
RP Ramisch, JL (reprint author), No Illinois Univ, Sch Family Consumer & Nutr Sci, De Kalb, IL 60115 USA.
EM jramisch@niu.edu
CR Altiere MJ, 2009, J CHILD FAM STUD, V18, P83, DOI 10.1007/s10826-008-9209-y
   Benson PR, 2011, J AUTISM DEV DISORD, V41, P1675, DOI 10.1007/s10803-011-1198-9
   Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
   Brobst J. B., 2009, FOCUS AUTISM OTHER D, V24, P33
   Brown J, 2007, CHILD YOUTH SERV REV, V29, P1235, DOI 10.1016/j.childyouth.2007.05.009
   Centers for Disease Control and Prevention, 2012, MMWR-MORBID MORTAL W, V61, pSS
   Crane DR, 2000, AM J FAM THER, V28, P53, DOI 10.1080/019261800261815
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   Eddy L. L., 1999, J FAMILY NURSING, V5, P10, DOI 10.1177/107484079900500102
   Everitt BS, 2011, CLUSTER ANAL
   Fletcher Paula C, 2012, Issues Compr Pediatr Nurs, V35, P45, DOI 10.3109/01460862.2012.645407
   Freedman BH, 2012, J AUTISM DEV DISORD, V42, P539, DOI 10.1007/s10803-011-1269-y
   Gau SSF, 2012, RES AUTISM SPECT DIS, V6, P263, DOI 10.1016/j.rasd.2011.05.007
   Gray DE, 2002, J INTELLECT DEV DIS, V27, P215, DOI 10.1080/1366825021000008639
   Hamlyn-Wright S, 2007, AUTISM, V11, P489, DOI 10.1177/1362361307083258
   Hartley SL, 2010, J FAM PSYCHOL, V24, P449, DOI 10.1037/a0019847
   Herman SE, 2005, AM J COMMUN PSYCHOL, V36, P343, DOI 10.1007/s10464-005-8630-2
   Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
   Hock RM, 2012, CHILD FAM SOC WORK, V17, P406, DOI 10.1111/j.1365-2206.2011.00794.x
   Jackson KM, 2002, ORGAN RES METHODS, V5, P307, DOI 10.1177/109442802237114
   Johnsen JA, 2000, EVAL PROGRAM PLANN, V23, P67, DOI 10.1016/S0149-7189(99)00038-5
   Kersh J, 2006, J INTELL DISABIL RES, V50, P883, DOI 10.1111/j.1365-2788.2006.00906.x
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lee GK, 2009, J DEV PHYS DISABIL, V21, P93, DOI 10.1007/s10882-008-9128-2
   Little Liza, 2002, Pediatr Nurs, V28, P565
   Myers BJ, 2009, RES AUTISM SPECT DIS, V3, P670, DOI 10.1016/j.rasd.2009.01.004
   Neff LA, 2009, J PERS SOC PSYCHOL, V97, P435, DOI 10.1037/a0015663
   O'Brien M, 2007, FAM RELAT, V56, P135
   Phelps KW, 2009, J INTELLECT DEV DIS, V34, P27, DOI 10.1080/13668250802690930
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   SCHUMM WR, 1985, PSYCHOL REP, V56, P719
   Siklos S, 2007, RES DEV DISABIL, V28, P9, DOI 10.1016/j.ridd.2005.09.003
   Sivberg B, 2002, AUTISM, V6, P397, DOI 10.1177/1362361302006004006
   TROCHIM WMK, 1989, EVAL PROGRAM PLANN, V12, P1, DOI 10.1016/0149-7189(89)90016-5
   Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
NR 35
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1062-1024
EI 1573-2843
J9 J CHILD FAM STUD
JI J. Child Fam. Stud.
PD AUG
PY 2014
VL 23
IS 6
BP 975
EP 988
DI 10.1007/s10826-013-9753-y
PG 14
WC Family Studies; Psychology, Developmental; Psychiatry
SC Family Studies; Psychology; Psychiatry
GA AL4PM
UT WOS:000339114900003
ER

PT J
AU O'Neill, K
   LeCouteur, A
AF O'Neill, Katherine
   LeCouteur, Amanda
TI Naming the problem: a membership categorization analysis study of family
   therapy
SO JOURNAL OF FAMILY THERAPY
LA English
DT Article
DE membership categorization analysis; family therapy; high-functioning
   autism; school exclusion
ID DISCOURSE ANALYSIS; REFLECTIONS
AB Discursive research has examined family therapy as a process of collaboratively negotiating a preferable account of the problem. The present study uses membership categorization analysis to examine how this process occurs in a sequence of family therapy sessions with the family of a 15-year-old boy diagnosed with high-functioning autism and experiencing conflict with his school. The analysis focuses on the deployment of the membership categorization device 'disability' in the construction of the problem and the use of the devices 'family' and 'stages-of-life' to construct a new, problem-dissolving account. Conclusions are drawn about the potential usefulness of recategorization via naturally occurring membership categorization devices in constructing solutions in family therapy.
C1 [O'Neill, Katherine] New England Medicare Local, Inverell, NSW 2360, Australia.
   [LeCouteur, Amanda] Univ Adelaide, Fac Hlth Sci, Sch Psychol, Adelaide, SA 5005, Australia.
RP O'Neill, K (reprint author), New England Medicare Local, 20 Chester St, Inverell, NSW 2360, Australia.
EM koneill@live.com.au
CR ANDERSON H, 1988, FAM PROCESS, V27, P371, DOI 10.1111/j.1545-5300.1988.00371.x
   Avdi E, 2005, PSYCHOL PSYCHOTHER-T, V78, P493, DOI 10.1348/147608305X52586
   Avdi E, 2000, J Health Psychol, V5, P241, DOI 10.1177/135910530000500214
   Baker C., 2000, CULTURE TEXT DISCOUR, P99
   Baker C. D., 2004, QUALITATIVE RES THEO, P162
   Baron- Cohen S., 2002, FOCUS AUTISM OTHER D, V17, P186, DOI 10.1177/10883576020170030801
   Buttny R., 1995, TALK CLIN EXPLORATIO, P19
   Coppersmith E. I., 1981, J STRATEGIC SYSTEMIC, V1, P1
   EDWARDS D, 1995, RES LANG SOC INTERAC, V28, P319, DOI 10.1207/s15327973rlsi2804_1
   Farrugia D, 2009, SOCIOL HEALTH ILL, V31, P1011, DOI 10.1111/j.1467-9566.2009.01174.x
   Fruggieri L., 1992, THERAPY SOCIAL CONST, P40
   Guilfoyle M, 2002, J FAM THER, V24, P298, DOI 10.1111/1467-6427.00218
   Hodge N, 2005, DISABIL SOC, V20, P345, DOI 10.1080/09687590500060810
   Kelly G. A., 1955, PSYCHOL PERSONAL CON
   Kogan SM, 1998, J FAM THER, V20, P229, DOI 10.1111/1467-6427.00085
   Mehan H., 1996, DISCOURSE THEORY PRA, P345
   Nikander P., 2002, AGE ACTION MEMBERSHI
   POCOCK D, 1995, J FAM THER, V17, P149, DOI 10.1111/j.1467-6427.1995.tb00011.x
   Sacks H., 1992, LECT CONVERSATION
   Schegloff EA, 2007, J PRAGMATICS, V39, P462, DOI 10.1016/j.pragma.2006.07.007
   SLUZKI CE, 1992, FAM PROCESS, V31, P217, DOI 10.1111/j.1545-5300.1992.00217.x
   Thomas S, 2011, BRIT J LEARN DISABIL, V39, P225, DOI 10.1111/j.1468-3156.2010.00659.x
   Wing L, 2005, J AUTISM DEV DISORD, V35, P197, DOI 10.1007/s10803-005-1998-x
NR 23
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0163-4445
EI 1467-6427
J9 J FAM THER
JI J. Fam. Ther.
PD AUG
PY 2014
VL 36
IS 3
BP 268
EP 286
DI 10.1111/1467-6427.12008
PG 19
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA AL6YI
UT WOS:000339279300005
ER

PT J
AU Williams, JL
   Faucett, WA
   Smith-Packard, B
   Wagner, M
   Williams, MS
AF Williams, Janet L.
   Faucett, W. Andrew
   Smith-Packard, Bethanny
   Wagner, Monisa
   Williams, Marc S.
TI An Assessment of Time Involved in Pre-test Case Review and Counseling
   for a Whole Genome Sequencing Clinical Research Program
SO JOURNAL OF GENETIC COUNSELING
LA English
DT Article
DE Whole genome sequencing; Time study; Electronic health record; Genetic
   counseling; Intellectual disability
ID EXOME
AB Whole genome sequencing (WGS) is being used for evaluation of individuals with undiagnosed disease of suspected genetic origin. Implementing WGS into clinical practice will place an increased burden upon care teams with regard to pre-test patient education and counseling about results. To quantitate the time needed for appropriate pre-test evaluation of participants in WGS testing, we documented the time spent by our clinical research group on various activities related to program preparation, participant screening, and consent prior to WGS. Participants were children or young adults with autism, intellectual or developmental disability, and/or congenital anomalies, who have remained undiagnosed despite previous evaluation, and their biologic parents. Results showed that significant time was spent in securing allocation of clinical research space to counsel participants and families, and in acquisition and review of participant's medical records. Pre-enrollment chart review identified two individuals with existing diagnoses resulting in savings of $30,000 for the genome sequencing alone, as well as saving hours of personnel time for genome interpretation and communication of WGS results. New WGS programs should plan for costs associated with additional pre-test administrative planning and patient evaluation time that will be required to provide high quality care.
C1 [Williams, Janet L.; Faucett, W. Andrew; Smith-Packard, Bethanny; Wagner, Monisa; Williams, Marc S.] Geisinger Hlth Syst, Genom Med Inst, Danville, PA 17822 USA.
RP Williams, JL (reprint author), Geisinger Hlth Syst, Genom Med Inst, 100 N Acad Ave, Danville, PA 17822 USA.
EM jlwilliams3@geisinger.edu
FU IRB approved program "Whole Genome Sequencing for Undiagnosed Children"
FX This work was funded with internal Geisinger Health System research
   funding for the IRB approved program "Whole Genome Sequencing for
   Undiagnosed Children." We are grateful for the vision articulated by
   David Ledbetter, W. Andrew Faucett, and Judith Argon in challenging the
   leadership to fund exploratory use of WGS. We would like to thank the
   genome workgroup and the program oversight committee for their
   invaluable contribution. We would like to thank Sandy M. Field for her
   editorial assistance in the preparation of this manuscript. We are
   particularly grateful to the study participants who agreed to embark on
   this journey into the use of whole genome sequencing in undiagnosed
   children.
CR Baars MJH, 2005, GENET MED, V7, P605, DOI 10.1097/01.gim.000oi82895.28432.c7
   Bensend T. A., 2013, J GENETIC COUNSELING
   Bick D, 2011, CURR OPIN PEDIATR, V23, P594, DOI 10.1097/MOP.0b013e32834b20ec
   Giardiello FM, 1997, NEW ENGL J MED, V336, P823, DOI 10.1056/NEJM199703203361202
   Need AC, 2012, J MED GENET, V49, P353, DOI 10.1136/jmedgenet-2012-100819
   Plon SE, 2011, GENET MED, V13, P148, DOI 10.1097/GIM.0b013e318207f564
   Tabor HK, 2012, AM J MED GENET A, V158A, P1310, DOI 10.1002/ajmg.a.35328
   Worthey E., 2012, BMC P S6, V6, P011
NR 8
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-7700
EI 1573-3599
J9 J GENET COUNS
JI J. Genet. Couns.
PD AUG
PY 2014
VL 23
IS 4
BP 516
EP 521
DI 10.1007/s10897-014-9697-4
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AL8FV
UT WOS:000339374400010
PM 24573557
ER

PT J
AU Asaro-Saddler, K
   Bak, N
AF Asaro-Saddler, Kristie
   Bak, Nicole
TI Persuasive Writing and Self-Regulation Training for Writers With Autism
   Spectrum Disorders
SO JOURNAL OF SPECIAL EDUCATION
LA English
DT Article
DE autism spectrum disorders; writing instruction; self-regulation
ID LEARNING-DISABLED STUDENTS; STRUGGLING YOUNG WRITERS;
   STRATEGY-DEVELOPMENT; ASPERGER-SYNDROME; EXECUTIVE DYSFUNCTION; PLANNING
   INSTRUCTION; DISABILITIES; CHILDREN; ADOLESCENTS; PERFORMANCE
AB In this single-subject study, we examined the effects of a persuasive writing and self-regulation strategy on the writing of children with autism spectrum disorders (ASD). Six children with ASD worked in pairs to learn a mnemonic-based strategy for planning and writing a persuasive essay using the self-regulated strategy development (SRSD) approach. Postintervention analysis revealed increases for all students in number of essay elements and holistic quality. Evidence of planning and self-regulation behaviors was also noted. Results support the assertion that utilizing a peer component to teach strategy instruction coupled with self-regulation procedures can positively affect the writing of children with ASD.
C1 [Asaro-Saddler, Kristie; Bak, Nicole] SUNY Albany, Albany, NY 12222 USA.
RP Asaro-Saddler, K (reprint author), SUNY Albany, ED 228, Albany, NY 12222 USA.
EM ksaddler@albany.edu
CR Asaro K, 2009, INTERV SCH CLIN, V44, P268, DOI 10.1177/1053451208330895
   Asaro-Saddler K, 2012, TOP LANG DISORD, V32, P361, DOI 10.1097/TLD.0b013e318271813f
   Asaro-Saddler K, 2010, EXCEPT CHILDREN, V77, P107
   Baird R., 2006, WRITING, V29, P16
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Boscolo P., 1990, FIRST LANG, V10, P217, DOI DOI 10.1177/014272379001003003
   Broun L., 2009, TEACHING EXCEPTIONAL, V42, P14
   Brown HM, 2011, J AUTISM DEV DISORD, V41, P1464, DOI 10.1007/s10803-010-1168-7
   Callahan K, 2008, J AUTISM DEV DISORD, V38, P678, DOI 10.1007/s10803-007-0434-9
   Campbell JM, 2004, BEHAV MODIF, V28, P234, DOI 10.1177/0145445503259264
   Chan JM, 2009, RES AUTISM SPECT DIS, V3, P876, DOI 10.1016/j.rasd.2009.04.003
   Chandler-Olcott K., 2008, LAND WE CAN SHARE
   Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
   Daiute C, 2002, LANGUAGE, LITERACY, AND COGNITIVE DEVELOPMENT, P193
   Delano M. F., 2007, FOCUS AUTISM OTHER D, V22, P252, DOI DOI 10.1177/10883576070220040701
   Delano ME, 2007, J APPL BEHAV ANAL, V40, P345, DOI 10.1901/jaba.2007.50-06
   De la Paz S, 2001, INTERV SCH CLIN, V36, P234, DOI 10.1177/105345120103600409
   DeLaPaz S, 1997, EXCEPT CHILDREN, V63, P167
   Dray AJ, 2009, J APPL DEV PSYCHOL, V30, P116, DOI 10.1016/j.appdev.2008.11.003
   Falk-Ross F., 2004, TEACHING EXCEPTIONAL, V36, P48
   Felton MK, 2004, J ADOLESC ADULT LIT, V47, P672
   FERRETTI RP, 2000, J EDUC PSYCHOL, V92, P694, DOI DOI 10.1037/0022-0663.92.4.694
   Graham S., 2007, WRITING NEXT EFFECTI
   Graham S., HDB LEARNING DISABIL
   GRAHAM S, 1989, EXCEPT CHILDREN, V56, P201
   Graham S., 2003, HDB RES LEARNING DIS, P383
   HARRIS KR, 1985, LEARN DISABILITY Q, V8, P27, DOI 10.2307/1510905
   Graham S, 2005, CONTEMP EDUC PSYCHOL, V30, P207, DOI 10.1016/j.cedpsych.2004.08.001
   GRAHAM S, 1990, J EDUC PSYCHOL, V82, P781, DOI 10.1037//0022-0663.82.4.781
   Griffin HC, 2006, INTERV SCH CLIN, V41, P150, DOI 10.1177/10534512060410030401
   Griswold D. E., 2002, FOCUS AUTISM OTHER D, V17, P94, DOI 10.1177/10883576020170020401
   Harris K. R., 1996, MAKING WRITING PROCE
   Harris K. R., 2008, POWERFUL WRITING STR
   Harris K. R., 2005, WRITING BETTER
   Harris KR, 2006, AM EDUC RES J, V43, P295, DOI 10.3102/00028312043002295
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Hillock J., 2011, AUTISM TEACHERS PERS, P321
   Joseph RM, 2005, DEV NEUROPSYCHOL, V27, P361, DOI 10.1207/s15326942dn2703_4
   Kanner L, 1943, NERV CHILD, V2, P217
   Little MA, 2010, BEHAV DISORDERS, V35, P157
   Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
   MacArthur C. A., 1991, LEARNING DISABILITIE, V6, P201
   Mason LH, 2010, BEHAV DISORDERS, V35, P140
   Mason LH, 2011, J SPEC EDUC, V44, P205, DOI 10.1177/0022466909350780
   Mastropieri MA, 2009, BEHAV DISORDERS, V35, P19
   Moore S. T., 2002, ASPERGER SYNDROME EL
   Myles BS, 2003, EDUC TRAIN MENT RET, V38, P362
   National Professional Development Center on Autism Spectrum Disorders, EV BAS PRACT PEER ME
   Nippold MA, 2005, LANG SPEECH HEAR SER, V36, P125, DOI 10.1044/0161-1461(2005/012)
   Reid R, 2006, EXCEPT CHILDREN, V73, P53
   Saddler B., 2004, EXCEPTIONALITY, V12, P3, DOI 10.1207/s15327035ex1201_2
   Saddler B, 2007, LEARN DISABILITY Q, V30, P223
   Saddler B, 2006, LEARN DISABILITY Q, V29, P291
   Safran S. P., 2001, EXCEPT CHILDREN, V67, P151
   Salahu-Din D., 2008, 2008468 NCES US DEP
   Sansoti F., 2010, HIGH FUNCTIONING AUT
   SCRUGGS TE, 1987, REM SPEC EDUC, V8, P24
   Simpson RL, 2005, FOCUS AUTISM OTHER D, V20, P140, DOI 10.1177/10883576050200030201
   STODDARD B, 1993, RES TEACH ENGL, V27, P76
   Topping K. J., 2005, ED PSYCHOL, V25, P631, DOI DOI 10.1080/01443410500345172
NR 60
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-4669
EI 1538-4764
J9 J SPEC EDUC
JI J. Spec. Educ.
PD AUG
PY 2014
VL 48
IS 2
BP 92
EP 105
DI 10.1177/0022466912474101
PG 14
WC Education, Special
SC Education & Educational Research
GA AL2AJ
UT WOS:000338927900002
ER

PT J
AU Regan, K
   Berkeley, S
   Hughes, M
   Kirby, S
AF Regan, Kelley
   Berkeley, Sheri
   Hughes, Melissa
   Kirby, Suzanne
TI Effects of Computer-Assisted Instruction for Struggling Elementary
   Readers With Disabilities
SO JOURNAL OF SPECIAL EDUCATION
LA English
DT Article
DE computer-assisted instruction; word recognition; reading; direct
   instruction
ID LEARNING-DISABILITIES; READING-ACHIEVEMENT; STUDENTS; TECHNOLOGY;
   INTERVENTIONS; COMPREHENSION; FLUENCY; AUTISM; SKILLS; RISK
AB Despite a lack of conclusive evidence, many researchers in the field view computer-assisted instruction (CAI) as an opportunity for improved instruction for students with disabilities. This study examined the effects of a CAI program, Lexia Strategies for Older Students (SOS) T on the word recognition skills of four, upper elementary students with mild disabilities. This study used a multiple-probe design across three targeted reading skill conditions per student. Findings revealed that some students were able to meet mastery of basic word reading skills with Lexia SOS alone, while others needed additional direct instruction. Student perceptions of Lexia SOS were positive. Results have particular implications for instruction in classrooms beyond the primary grades (K-3) when the focus of the curriculum shifts away from basic decoding instruction. Directions for future research are discussed.
C1 [Regan, Kelley; Berkeley, Sheri; Hughes, Melissa; Kirby, Suzanne] George Mason Univ, Fairfax, VA 22030 USA.
RP Regan, K (reprint author), George Mason Univ, Finley Bldg,Room 213,4400 Univ Dr,MS 1F2, Fairfax, VA 22030 USA.
EM kregan@gmu.edu
CR Blischak DM, 2003, TOP LANG DISORD, V23, P293
   Boone R, 2007, READ RES QUART, V42, P135, DOI 10.1598/RRQ.42.1.5
   Bouck Emily C, 2009, Journal of Special Education Technology, V24
   Burns MK, 2002, INTERV SCH CLIN, V38, P8, DOI 10.1177/10534512020380010201
   Carnine D. W., 2004, DIRECT INSTRUCTION R
   Cassady J. C., 2005, READ WRIT Q, V21, P361, DOI 10.1080/10573560591002277
   Chard DJ, 2002, J LEARN DISABIL-US, V35, P386, DOI 10.1177/00222194020350050101
   Clarfield J, 2005, SCHOOL PSYCHOL REV, V34, P246
   Fitzgerald G, 2008, J EDUC COMPUT RES, V38, P201, DOI 10.2190/EC.38.2.e
   Gast D. L., 2010, SINGLE SUBJECT RES M, P276
   GICKLING EE, 1985, EXCEPT CHILDREN, V52, P205
   Hall T., 2000, ED TREATMENT CHILDRE, V23, P173
   Hines SJ, 2007, READ WRIT, V20, P539, DOI 10.1007/s11145-007-9052-3
   Horner RH, 2005, EXCEPT CHILDREN, V71, P165
   Hudson RF, 2011, LEARN DISABIL RES PR, V26, P15, DOI 10.1111/j.1540-5826.2010.00321.x
   Hudson R. F., 2009, READ WRIT Q, V25, P4, DOI [10.1080/10573560802491208, DOI 10.1080/10573560802491208]
   Judge S, 2010, READ WRIT Q, V27, P153, DOI 10.1080/10573569.2011.532722
   Kara I., 2008, J INSTRUCTIONAL PSYC, V35, P357
   Katz LA, 2008, EXCEPT CHILDREN, V74, P235
   Kazdin A. E., 1982, SINGLE CASE RES DESI
   Kennedy MJ, 2010, LEARN DISABILITY Q, V33, P289
   Kim AH, 2006, REM SPEC EDUC, V27, P235, DOI 10.1177/07419325060270040401
   Kratochwill T. R., 2010, SINGLE CASE DESIGNS
   Levy BA, 1997, LEARN DISABILITY Q, V20, P173, DOI 10.2307/1511307
   Lexia Learning Systems, 2001, STRAT OLD STUD
   Lyon GR, 1996, FUTURE CHILD, V6, P54, DOI 10.2307/1602494
   Macaruso P, 2006, J RES READ, V29, P162, DOI 10.1111/j.1467-9817.2006.00282.x
   Maccini P, 2002, LEARN DISABILITY Q, V25, P247, DOI 10.2307/1511356
   Mastropieri M. A., 2010, INCLUSIVE CLASSROOM
   McKenna MC, 2007, READ RES QUART, V42, P140, DOI 10.1598/RRQ.42.1.6
   National Reading Panel, 2000, TEACH CHILDR READ EV
   Okolo C. M., 2007, J SPECIAL ED TECHNOL, V22, P19
   Pennington RC, 2010, FOCUS AUTISM DEV DIS, V25, P239, DOI 10.1177/1088357610378291
   Rabiner D, 2000, J AM ACAD CHILD PSY, V39, P859, DOI 10.1097/00004583-200007000-00014
   Read Naturally, 2008, READ FLUENC BENCHM A
   Regan K, 2012, INTERV SCH CLIN, V47, P276, DOI 10.1177/1053451211430117
   Rodman A., 2009, EUROPEAN J SPECIAL N, V24, P103
   Rupley W. H., 2009, READ WRIT Q, V25, P125, DOI DOI 10.1080/10573560802683523
   Scammacca N, 2007, EXTENSIVE READING IN
   Stetter Maria Earman, 2010, Journal of Special Education Technology, V25
   Twyman T., 2006, Journal of Special Education Technology, V21
   Torgesen JK, 2010, ANN DYSLEXIA, V60, P40, DOI 10.1007/s11881-009-0032-y
   TORGESEN JK, 1995, LEARN DISABILITY Q, V18, P76, DOI 10.2307/1511196
   Vail C. O., 2005, J SPECIAL ED TECHNOL, V20, P5
   Walker A., 2008, READING PSYCHOL, V29, P266, DOI 10.1080/02702710801982019
   Wanzek J, 2010, READ WRIT, V23, P889, DOI 10.1007/s11145-009-9179-5
   Wells J., 2006, INTERNET ACCESS US P
   What Works Clearinghouse, 2009, LEX READ
NR 48
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-4669
EI 1538-4764
J9 J SPEC EDUC
JI J. Spec. Educ.
PD AUG
PY 2014
VL 48
IS 2
BP 106
EP 119
DI 10.1177/0022466913497261
PG 14
WC Education, Special
SC Education & Educational Research
GA AL2AJ
UT WOS:000338927900003
ER

PT J
AU Becker, JAJ
   Clesse, D
   Spiegelhalter, C
   Schwab, Y
   Le Merrer, J
   Kieffer, BL
AF Becker, Jerome A. J.
   Clesse, Daniel
   Spiegelhalter, Coralie
   Schwab, Yannick
   Le Merrer, Julie
   Kieffer, Brigitte L.
TI Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by
   Facilitated mGluR4 Activity
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID MESSENGER-RNA EXPRESSION; SPECTRUM DISORDERS; SOCIAL REJECTION; BASAL
   GANGLIA; GENE OPRM1; REWARD; BEHAVIOR; MOUSE; CHILDREN; OXYTOCIN
AB The etiology of Autism Spectrum Disorders (ASDs) remains largely unknown. Identifying vulnerability genes for autism represents a major challenge in the field and allows the development of animal models for translational research. Mice lacking the mu opioid receptor gene (Oprm1(-/-)) were recently proposed as a monogenic mouse model of autism, based on severe deficits in social behavior and communication skills. We confirm this hypothesis by showing that adult Oprm1(-/-) animals recapitulate core and multiple comorbid behavioral symptoms of autism and also display anatomical, neurochemical, and genetic landmarks of the disease. Chronic facilitation of mGluR4 signaling, which we identified as a novel pharmacological target in ASDs in these mice, was more efficient in alleviating behavioral deficits than the reference molecule risperidone. Altogether, our data provide first evidence that disrupted mu opioid receptor signaling is sufficient to trigger a comprehensive autistic syndrome, maybe through blunted social reward processes, and this mouse model opens promising avenues for therapeutic innovation.
C1 [Becker, Jerome A. J.; Le Merrer, Julie; Kieffer, Brigitte L.] Univ Strasbourg, CNRS, INSERM,UMR 7104,U 964, Inst Genet & Biol Mol & Cellulaire,Dept Med Trans, Illkirch Graffenstaden, France.
   [Clesse, Daniel] CNRS, Inst Neurosci Cellulaires & Integrat, Dept Neurobiol Rythmes, UPR 3212, Strasbourg, France.
   [Spiegelhalter, Coralie; Schwab, Yannick] Univ Strasbourg, CNRS, Imaging Ctr,U 964, INSERM,Inst Genet & Biol Mol & Cellulaire,UMR 710, Illkirch Graffenstaden, France.
RP Kieffer, BL (reprint author), Inst Biol Mol & Cellulaire, Dept Neuro Biol & Genet, F-67404 Illkirch Graffenstaden, France.
EM briki@igbmc.fr
FU Centre National de la Recherche Scientifique (CNRS); Institut National
   de la Sante et de la Recherche Medicale (INSERM); Universite de
   Strasbourg; Fondation Universite de Strasbourg - Pierre Fabre
   Laboratories; National Institutes of Health (NIAAA) [16658]; National
   Institutes of Health (NIDA) [005010]
FX This work was supported by the Centre National de la Recherche
   Scientifique (CNRS), Institut National de la Sante et de la Recherche
   Medicale (INSERM), and Universite de Strasbourg. JLM acknowledges
   postdoctoral fellowship from the Fondation Universite de Strasbourg,
   generously funded by Pierre Fabre Laboratories. We thank the National
   Institutes of Health (NIAAA no. 16658 and NIDA no. 005010) for financial
   support. The authors declare no conflict of interest.
CR Albelda N, 2012, NEUROSCI BIOBEHAV R, V36, P47, DOI 10.1016/j.neubiorev.2011.04.006
   Amalric M, 2013, NEUROPHARMACOLOGY, V66, P53, DOI 10.1016/j.neuropharm.2012.05.026
   Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
   Argyropoulos A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00417
   Aupperle Robin L, 2010, Dialogues Clin Neurosci, V12, P517
   Bortolato M, 2011, INT REV NEUROBIOL, V100, P13, DOI 10.1016/B978-0-12-386467-3.00002-9
   Bradley SR, 1999, J COMP NEUROL, V407, P33
   Burkett JP, 2011, NEUROPSYCHOPHARMACOL, V36, P2200, DOI 10.1038/npp.2011.117
   Buxbaum JD, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-1
   Carlson GC, 2012, PHARMACOL BIOCHEM BE, V100, P850, DOI 10.1016/j.pbb.2011.02.003
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Cinque C, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.83
   Corti C, 2002, NEUROSCIENCE, V110, P403, DOI 10.1016/S0306-4522(01)00591-7
   Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x
   Defensor EB, 2012, PHYSIOL BEHAV, V107, P680, DOI 10.1016/j.physbeh.2012.03.024
   Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
   Dichter G, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-20
   Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Dolen G, 2013, NATURE, V501, P179, DOI 10.1038/nature12518
   Duvoisin RM, 2011, BEHAV BRAIN RES, V221, P50, DOI 10.1016/j.bbr.2011.02.049
   Ecker C, 2012, MOL PSYCHIATR, V18, P435
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Filliol D, 2000, NAT GENET, V25, P195
   Gaveriaux-Ruff C, 2002, NEUROPEPTIDES, V36, P62, DOI 10.1054/npep.2002.0900
   Grecksch G, 2004, N-S ARCH PHARMACOL, V369, P287, DOI 10.1007/s00210-004-0870-4
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   Horder J, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.53
   Hsu DT, 2013, MOL PSYCHIATR, V18, P1211, DOI 10.1038/mp.2013.96
   Ide S, 2010, NEUROPHARMACOLOGY, V58, P241, DOI 10.1016/j.neuropharm.2009.07.005
   Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
   Jamot L, 2003, GENES BRAIN BEHAV, V2, P80, DOI 10.1034/j.1601-183X.2003.00013.x
   Jang CG, 2001, MOL BRAIN RES, V94, P105, DOI 10.1016/S0169-328X(01)00222-4
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Kelleher RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035003
   Kohls G, 2012, SOCIAL COGNITIVE AFF, V8, P565, DOI 10.1093/scan/nss033
   Lam KSL, 2006, RES DEV DISABIL, V27, P254, DOI 10.1016/j.ridd.2005.03.003
   Le Merrer J, 2009, PHYSIOL REV, V89, P1379, DOI 10.1152/physrev.00005.2009
   Le Merrer J, 2012, ADDICT BIOL, V17, P1, DOI 10.1111/j.1369-1600.2011.00365.x
   Le Merrer J, 2013, NEUROPSYCHOPHARMACOL, V38, P1050, DOI 10.1038/npp.2013.1
   Maher Alicia R, 2012, J Manag Care Pharm, V18, pS1
   Matthes HWD, 1996, NATURE, V383, P819, DOI 10.1038/383819a0
   Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
   Moles A, 2004, SCIENCE, V304, P1983, DOI 10.1126/science.1095943
   Neuhaus E, 2010, CLIN PSYCHOL REV, V30, P733, DOI 10.1016/j.cpr.2010.05.007
   Oddi D, 2013, BEHAV BRAIN RES, V251, P75, DOI 10.1016/j.bbr.2013.01.002
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   RAWLEIGH JM, 1992, PHARMACOL BIOCHEM BE, V42, P317, DOI 10.1016/0091-3057(92)90533-L
   Robertson HR, 2011, J CHILD PSYCHOL PSYC, V52, P442, DOI 10.1111/j.1469-7610.2011.02380.x
   Robinson SJ, 2012, NEUROPSYCHOL REV, V22, P271, DOI 10.1007/s11065-012-9212-3
   Rojas DC, 2013, NEUROIMAGE, V86, P28, DOI DOI 10.1016/J.NEUROIMAGE.2013.01.045
   Roy S, 1998, MOL BRAIN RES, V56, P281, DOI 10.1016/S0169-328X(98)00051-5
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Slawinska A, 2013, NEUROPHARMACOLOGY, V66, P225, DOI 10.1016/j.neuropharm.2012.05.001
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   TESTA CM, 1994, J NEUROSCI, V14, P3005
   Trezza V, 2010, TRENDS PHARMACOL SCI, V31, P463, DOI 10.1016/j.tips.2010.06.008
   Trezza V, 2011, J NEUROSCI, V31, P6362, DOI 10.1523/JNEUROSCI.5492-10.2011
   Troisi A, 2011, SOC NEUROSCI-UK, V6, P88, DOI 10.1080/17470919.2010.482786
   van Kerkhof LW, 2013, BRAIN STRUCT FUNCT
   Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185
   Way BM, 2009, P NATL ACAD SCI USA, V106, P15079, DOI 10.1073/pnas.0812612106
   Weathington JM, 2012, HORM BEHAV, V62, P154, DOI 10.1016/j.yhbeh.2012.06.004
   White SW, 2012, AUTISM, V16, P453, DOI 10.1177/1362361311431951
   Whyatt Caroline, 2013, Front Integr Neurosci, V7, P51, DOI 10.3389/fnint.2013.00051
   Wohr M, 2011, SOC NEUROSCI-UK, V6, P76, DOI 10.1080/17470911003765560
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
NR 69
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD AUG
PY 2014
VL 39
IS 9
BP 2049
EP 2060
DI 10.1038/npp.2014.59
PG 12
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AL5ML
UT WOS:000339177800002
PM 24619243
ER

PT J
AU Scheele, D
   Kendrick, KM
   Khouri, C
   Kretzer, E
   Schlafer, TE
   Stoffel-Wagner, B
   Gunturkun, O
   Maier, W
   Hurlemann, R
AF Scheele, Dirk
   Kendrick, Keith M.
   Khouri, Christoph
   Kretzer, Elisa
   Schlaefer, Thomas E.
   Stoffel-Wagner, Birgit
   Guentuerkuen, Onur
   Maier, Wolfgang
   Hurlemann, Rene
TI An Oxytocin-Induced Facilitation of Neural and Emotional Responses to
   Social Touch Correlates Inversely with Autism Traits
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID SPECTRUM DISORDERS; CINGULATE CORTEX; PLASMA OXYTOCIN; INSULAR CORTEX;
   REWARD SYSTEM; HUMAN BRAIN; PLEASANT; HUMANS; EXPOSURE; MALES
AB Social communication through touch and mutual grooming can convey highly salient socio-emotional signals and has been shown to involve the neuropeptide oxytocin (OXT) in several species. Less is known about the modulatory influence of OXT on the neural and emotional responses to human interpersonal touch. The present randomized placebo (PLC)-controlled within-subject pharmaco-functional magnetic resonance imaging (fMRI) study was designed to test the hypothesis that a single intranasal dose of synthetic OXT (24 IU) would facilitate both neural and emotional responses to interpersonal touch in a context-(female vs male touch) and trait( autistic trait load) specific manner. Specifically, the experimental rationale was to manipulate the reward value of interpersonal touch independent of the intensity and type of actual cutaneous stimulation administered. Thus, 40 heterosexual males believed that they were touched by either a man or a woman, although in fact an identical pattern of touch was always given by the same female experimenter blind to condition type. Our results show that OXT increased the perceived pleasantness of female, but not male touch, and associated neural responses in insula, precuneus, orbitofrontal, and pregenual anterior cingulate cortex. Moreover, the behavioral and neural effects of OXT were negatively correlated with autistic-like traits. Taken together, this is the first study to show that the perceived hedonic value of human heterosexual interpersonal touch is facilitated by OXT in men, but that its behavioral and neural effects in this context are blunted in individuals with autistic traits.
C1 [Scheele, Dirk; Khouri, Christoph; Kretzer, Elisa; Schlaefer, Thomas E.; Maier, Wolfgang; Hurlemann, Rene] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany.
   [Scheele, Dirk; Khouri, Christoph; Kretzer, Elisa; Hurlemann, Rene] Univ Bonn, Div Med Psychol, D-53105 Bonn, Germany.
   [Kendrick, Keith M.] UESTC, Sch Life Sci & Technol, Key Lab Neuroinformat, Chengdu, Peoples R China.
   [Schlaefer, Thomas E.] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD USA.
   [Schlaefer, Thomas E.] Johns Hopkins Univ, Dept Mental Hlth, Baltimore, MD USA.
   [Stoffel-Wagner, Birgit] Univ Bonn, Dept Clin Chem & Clin Pharmacol, D-53105 Bonn, Germany.
   [Guentuerkuen, Onur] Ruhr Univ Bochum, Dept Biopsychol, Bochum, Germany.
   [Maier, Wolfgang] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany.
RP Hurlemann, R (reprint author), Univ Bonn, Dept Psychiat, Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM renehurlemann@me.com
RI Hurlemann, Rene/G-4164-2012
OI Hurlemann, Rene/0000-0003-2628-565X
FU Ministry of Innovation, Science, Research and Technology of the German
   State of North Rhine-Westphalia (MIWFT); University of Bonn; National
   Natural Science Foundation of China [91132720]
FX RH was supported by a Starting Independent Researcher Grant
   ('NEMO-Neuromodulation of Emotion') jointly provided by the Ministry of
   Innovation, Science, Research and Technology of the German State of
   North Rhine-Westphalia (MIWFT) and the University of Bonn. KMK was
   supported by National Natural Science Foundation of China grant
   (91132720).
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
   Borrow AP, 2012, HORM BEHAV, V61, P266, DOI 10.1016/j.yhbeh.2011.11.001
   Cabanis M, 2013, COGN AFFECT BEHAV NE, V13, P330, DOI 10.3758/s13415-012-0143-5
   Cascio CJ, 2012, AUTISM RES, V5, P231, DOI 10.1002/aur.1224
   Cauda F, 2011, NEUROIMAGE, V55, P8, DOI 10.1016/j.neuroimage.2010.11.049
   Craig AD, 2002, NAT REV NEUROSCI, V3, P655, DOI 10.1038/nrn894
   Danevova V, 2013, HORM METAB RES, V45, P845, DOI 10.1055/s-0033-1348265
   DRAGO F, 1986, BRAIN RES, V368, P287, DOI 10.1016/0006-8993(86)90573-1
   Dunbar RIM, 2010, NEUROSCI BIOBEHAV R, V34, P260, DOI 10.1016/j.neubiorev.2008.07.001
   Eckstein M, 2013, NERVENARZT, V84, P1321, DOI 10.1007/s00115-013-3832-6
   Ellingsen DM, 2014, PSYCHONEUROENDOCRINO, V39, P11, DOI 10.1016/j.psyneuen.2013.09.017
   Gallace A, 2010, NEUROSCI BIOBEHAV R, V34, P246, DOI 10.1016/j.neubiorev.2008.10.004
   Gazzola V, 2012, P NATL ACAD SCI USA, V109, pE1657, DOI 10.1073/pnas.1113211109
   Gordon I, 2013, HUM BRAIN MAPP, V34, P914, DOI 10.1002/hbm.21480
   Graziano MSA, 2002, NEURON, V34, P841, DOI 10.1016/S0896-6273(02)00698-0
   Groppe SE, 2013, BIOL PSYCHIAT, V74, P172, DOI 10.1016/j.biopsych.2012.12.023
   Hertenstein MJ, 2006, GENET SOC GEN PSYCH, V132, P5, DOI 10.3200/MONO.132.1.5-94
   Holt-Lunstad J, 2008, PSYCHOSOM MED, V70, P976, DOI 10.1097/PSY.0b013e318187aef7
   Hsu DT, 2013, MOL PSYCHIATR, V18, P1211, DOI 10.1038/mp.2013.96
   Hua QP, 2008, CELL MOL NEUROBIOL, V28, P57, DOI 10.1007/s10571-007-9228-z
   Huster RJ, 2010, HUM BRAIN MAPP, V31, P1260, DOI 10.1002/hbm.20933
   Kennedy DP, 2009, NAT NEUROSCI, V12, P1226, DOI 10.1038/nn.2381
   Lindgren L, 2012, NEUROIMAGE, V59, P3427, DOI 10.1016/j.neuroimage.2011.11.013
   Loken LS, 2009, NAT NEUROSCI, V12, P547, DOI 10.1038/nn.2312
   Lovero KL, 2009, NEUROIMAGE, V45, P976, DOI 10.1016/j.neuroimage.2008.12.070
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   MacDonald K, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00035
   McCabe C, 2008, SOC COGN AFFECT NEUR, V3, P97, DOI 10.1093/scan/nsn005
   MEISENBERG G, 1982, NEUROPHARMACOLOGY, V21, P309, DOI 10.1016/0028-3908(82)90093-4
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Morhenn V, 2012, ALTERN THER HEALTH M, V18, P11
   Morrison I, 2011, J NEUROSCI, V31, P9554, DOI 10.1523/JNEUROSCI.0397-11.2011
   Ogawa M, 2013, NEURON, V77, P251, DOI 10.1016/j.neuron.2012.11.006
   PEDERSEN CA, 1988, ANN NY ACAD SCI, V525, P245, DOI 10.1111/j.1749-6632.1988.tb38610.x
   Riem MME, 2013, EUR NEUROPSYCHOPHARM, V23, P1288, DOI 10.1016/j.euroneuro.2013.01.011
   Riem MME, 2012, NEUROPSYCHOPHARMACOL, V37, P1257, DOI 10.1038/npp.2011.313
   Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
   Rolls ET, 2003, CEREB CORTEX, V13, P308, DOI 10.1093/cercor/13.3.308
   SANDERS G, 1990, PSYCHONEUROENDOCRINO, V15, P47, DOI 10.1016/0306-4530(90)90046-C
   Scheele D, 2013, P NATL ACAD SCI USA, V110, P20308, DOI 10.1073/pnas.1314190110
   Scheele D, 2012, J NEUROSCI, V32, P16074, DOI 10.1523/JNEUROSCI.2755-12.2012
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Striepens N, 2013, SCI REP-UK, V3, DOI 10.1038/srep03440
   Striepens N, 2014, PSYCHONEUROENDOCRINO, V39, P74, DOI 10.1016/j.psyneuen.2013.09.026
   Striepens N, 2012, P NATL ACAD SCI USA, V109, P18144, DOI 10.1073/pnas.1208852109
   Striepens N, 2011, FRONT NEUROENDOCRIN, V32, P426, DOI 10.1016/j.yfrne.2011.07.001
   Taylor SE, 2010, PSYCHOL SCI, V21, P3, DOI 10.1177/0956797609356507
   UVNASMOBERG K, 1993, ACTA PHYSIOL SCAND, V149, P199, DOI 10.1111/j.1748-1716.1993.tb09612.x
   Vogt BA, 1995, HUM BRAIN MAPP, V3, P1, DOI 10.1002/hbm.460030102
   Voos AC, 2013, SOC COGN AFFECT NEUR, V8, P378, DOI 10.1093/scan/nss009
   Wikstrom S, 2003, INT J NEUROSCI, V113, P787, DOI 10.1080/00207450390200954
   WINSLOW JT, 1991, J NEUROSCI, V11, P2032
NR 54
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD AUG
PY 2014
VL 39
IS 9
BP 2078
EP 2085
DI 10.1038/npp.2014.78
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AL5ML
UT WOS:000339177800005
PM 24694924
ER

PT J
AU Jenkins, A
   Apud, JA
   Zhang, FY
   Decot, H
   Weinberger, DR
   Law, AJ
AF Jenkins, Aaron
   Apud, Jose A.
   Zhang, Fengyu
   Decot, Heather
   Weinberger, Daniel R.
   Law, Amanda J.
TI Identification of Candidate Single-Nucleotide Polymorphisms in NRXN1
   Related to Antipsychotic Treatment Response in Patients with
   Schizophrenia
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID COPY NUMBER VARIATIONS; CLOZAPINE RESPONSE; GENETIC-VARIATION; NICOTINE
   DEPENDENCE; ALPHA-NEUREXINS; ASSOCIATION; DELETIONS; DISORDERS;
   PHARMACOGENETICS; RECEPTORS
AB Neurexins are presynaptic neuronal adhesion molecules that interact with postsynaptic neuroligins to form an inter-synaptic complex required for synaptic specification and efficient neurotransmission. Deletions and point mutations in the neurexin 1 (NRXN1) gene are associated with a broad spectrum of neuropsychiatric and neurodevelopmental disorders, including autism, intellectual disability, epilepsy, developmental delay, and schizophrenia. Recently, small nucleotide polymorphisms in NRXN1 have been associated with antipsychotic drug response in patients with schizophrenia. Based on previous suggestive evidence of an impact on clozapine response in patients with schizophrenia, we conducted an association study of NRXN1 polymorphisms (rs12467557 and rs10490162) with antipsychotic treatment response in 54 patients with schizophrenia in a double blind, placebo-controlled NIMH inpatient crossover trial and examined for association with risk for schizophrenia in independent case-control and family-based clinical cohorts. Pharmacogenetic analysis in the placebo controlled trial revealed significant association of rs12467557and rs10490162 with drug response, whereby individuals homozygous for the A allele, at either SNP, showed significant improvement in positive symptoms, general psychopathology, thought disturbance, and negative symptoms, whereas patients carrying the G allele showed no overall response. Although we did not find evidence of the same NRXN1 SNPs being associated with results of the NIMH sponsored CATIE trial, other SNPs showed weakly positive signals. The family and case-control analyses for schizophrenia risk were negative. Our results provide confirmatory evidence of genetically determined differences in drug response in patients with schizophrenia related to NRXN1 variation. Furthermore, these findings potentially implicate NRXN1 in the therapeutic actions of antipsychotic drugs.
C1 [Jenkins, Aaron; Apud, Jose A.; Decot, Heather] NIMH, Clin Brain Disorders Branch, Genes Cognit & Psychosis Program, NIH, Bethesda, MD 20892 USA.
   [Jenkins, Aaron] Univ Kentucky, Coll Med, Lexington, KY USA.
   [Zhang, Fengyu; Weinberger, Daniel R.] Johns Hopkins Univ, Lieber Inst Brain Dev, Baltimore, MD USA.
   [Weinberger, Daniel R.] Johns Hopkins Sch Med, Dept Psychiat, Baltimore, MD USA.
   [Weinberger, Daniel R.] Johns Hopkins Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA.
   [Law, Amanda J.] Univ Colorado, Dept Psychiat, Sch Med, Aurora, CO 80045 USA.
   [Weinberger, Daniel R.; Law, Amanda J.] Univ Colorado, Dept Cell & Dev Biol, Sch Med, Aurora, CO 80045 USA.
RP Law, AJ (reprint author), Univ Colorado, Dept Psychiat, Sch Med, Mailstop 8344,RC1 North,RM 8101, Aurora, CO 80045 USA.
EM amanda.law@ucdenver.edu
FU Intramural Research Program of the National Institutes of Mental Health,
   National Institutes of Health
FX This work was supported by funds from the Intramural Research Program of
   the National Institutes of Mental Health, National Institutes of Health.
   We thank Bhaskar Kolachana for genotyping of the NIMH samples.
CR Apud JA, 2012, AM J PSYCHIAT, V169, P725, DOI 10.1176/appi.ajp.2012.11081214
   Bassett AS, 2008, HUM MOL GENET, V17, P4045, DOI 10.1093/hmg/ddn307
   Bena F, 2013, AM J MED GENET B, V162B, P388, DOI 10.1002/ajmg.b.32148
   Bierut LJ, 2007, HUM MOL GENET, V16, P24, DOI 10.1093/hmg/ddl441
   Bigos KL, 2011, MOL PSYCHIATR, V16, P620, DOI 10.1038/mp.2011.38
   Bigos KL, 2008, J CLIN PHARMACOL, V48, P157, DOI 10.1177/0091270007310385
   Chen XL, 2013, AM J HUM GENET, V92, P375, DOI 10.1016/j.ajhg.2013.02.006
   Dabell MP, 2013, AM J MED GENET A, V161A, P717, DOI 10.1002/ajmg.a.35780
   Docampo E, 2012, GENES BRAIN BEHAV, V11, P704, DOI 10.1111/j.1601-183X.2012.00815.x
   Dudanova I, 2006, J NEUROSCI, V26, P10599, DOI 10.1523/JNEUROSCI.1913-06.2006
   Duong L, 2012, AM J MED GENET B, V159B, P354, DOI 10.1002/ajmg.b.32036
   Fedorova L, 2003, GENETICA, V118, P123, DOI 10.1023/A:1024145407467
   Giegling I, 2013, EUR ARCH PSY CLIN N, V263, P65, DOI 10.1007/s00406-012-0348-1
   Grayton HM, 2012, PROG NEUROBIOL, V99, P81, DOI 10.1016/j.pneurobio.2012.07.005
   Hishimoto A, 2007, HUM MOL GENET, V16, P2880, DOI 10.1093/hmg/ddm247
   Ikeda M, 2008, PHARMACOGENOMICS, V9, P1437, DOI 10.2217/14622416.9.10.1437
   Ikeda M, 2010, BIOL PSYCHIAT, V67, P283, DOI 10.1016/j.biopsych.2009.08.034
   Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
   Kapur S, 2003, PROG NEURO-PSYCHOPH, V27, P1081, DOI 10.1016/j.pnpbp.2003.09.004
   KAY SR, 1991, COMPR PSYCHIAT, V32, P355, DOI 10.1016/0010-440X(91)90085-Q
   Kirov G, 2009, SCHIZOPHRENIA BULL, V35, P851, DOI 10.1093/schbul/sbp079
   Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323
   Law AJ, 2012, P NATL ACAD SCI USA, V109, P12165, DOI 10.1073/pnas.1206118109
   Lett TAP, 2011, SCHIZOPHR RES, V132, P121, DOI 10.1016/j.schres.2011.08.007
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lotrich FE, 2012, AM J PSYCHIAT, V169, P681, DOI 10.1176/appi.ajp.2012.12040457
   Malhotra AK, 2012, MOL PSYCHIATR, V17, P760, DOI 10.1038/mp.2011.146
   Malhotra AK, 2012, ARCH GEN PSYCHIAT, V69, P904, DOI 10.1001/archgenpsychiatry.2012.191
   Missler M, 2003, NATURE, V423, P939, DOI 10.1038/nature01755
   Missler M, 1998, J NEUROCHEM, V71, P1339
   Moller RS, 2013, EPILEPSIA, V54, P256, DOI 10.1111/epi.12078
   Muhleisen TW, 2011, SCHIZOPHR RES, V127, P35, DOI 10.1016/j.schres.2011.01.001
   Need AC, 2009, EUR J HUM GENET, V17, P946, DOI 10.1038/ejhg.2008.264
   Nussbaum J, 2008, HUM MOL GENET, V17, P1569, DOI 10.1093/hmg/ddn044
   Owen MJ, 2012, SCHIZOPHRENIA BULL, V38, P904, DOI 10.1093/schbul/sbs103
   Prathikanti S, 2005, BRIT MED BULL, V73-74, P107, DOI 10.1093/bmb/ldh055
   Ripke, 2013, NAT GENET, V45, P1150
   Rowen L, 2002, GENOMICS, V79, P587, DOI 10.1006/geno.2002.6734
   Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
   Shepard S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007853
   SNYDER SH, 1981, AM J PSYCHIAT, V138, P460
   Souza RP, 2010, HUM PSYCHOPHARM CLIN, V25, P582, DOI 10.1002/hup.1146
   Souza RP, 2008, PSYCHOPHARMACOLOGY, V200, P177, DOI 10.1007/s00213-008-1193-9
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
   Sullivan PF, 2008, MOL PSYCHIATR, V14, P1144
   Swaminathan S, 2012, CURR ALZHEIMER RES, V9, P801
   Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
   WEINBERGER DR, 1987, ARCH GEN PSYCHIAT, V44, P660
   Zhang C, 2010, NEURON, V66, P403, DOI 10.1016/j.neuron.2010.04.008
   Zhang JP, 2010, AM J PSYCHIAT, V167, P763, DOI 10.1176/appi.ajp.2009.09040598
NR 52
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD AUG
PY 2014
VL 39
IS 9
BP 2170
EP 2178
DI 10.1038/npp.2014.65
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AL5ML
UT WOS:000339177800014
PM 24633560
ER

PT J
AU Hervas, A
   Toma, C
   Romaris, P
   Ribases, M
   Salgado, M
   Bayes, M
   Balmana, N
   Cormand, B
   Maristany, M
   Guijarro, S
   Arranz, MJ
AF Hervas, Amaia
   Toma, Claudio
   Romaris, Patricia
   Ribases, Marta
   Salgado, Marta
   Bayes, Monica
   Balmana, Noemi
   Cormand, Bru
   Maristany, Marta
   Guijarro, Silvina
   Arranz, Maria J.
TI The involvement of serotonin polymorphisms in autistic spectrum
   symptomatology
SO PSYCHIATRIC GENETICS
LA English
DT Article
DE ASD; cognitive impairment; 5-HT2A; 5-HT2B; 5-HT4; 5-HT6; serotonin
ID 5-HT2A RECEPTOR-BINDING; EPISODIC MEMORY; DISORDERS; ASSOCIATION;
   COMMUNICATION; VARIANTS; SYSTEM
AB Background Autism spectrum disorders (ASD) are highly inherited developmental syndromes, resulting from a complex interaction between environmental and genetic factors. To date, only a limited number of genetic variants have been discovered with respect to autism, and their contribution to the development of the disorder has not been clearly determined. Investigation of specific autistic symptomatology may improve the chances of identifying related genes and may help to better understand these disorders.
   Materials and methods We investigated the contribution of 80 genetic variants in 15 serotonin genes to ASD phenotypes [intelligence quotation (IQ), intellectual disability (ID) and language onset delay (LD)] in a cohort of 141 children and young adults (121 male patients and 20 female patients, average age 14.5 +/- 5.1 years).
   Results Two polymorphisms in the HTR2B gene, rs10194776 and rs16827801, were associated with IQ (P = 0.0004 and 0.003, respectively), ID (P = 0.02 and 0.03) and LD (P = 0.04 and 0.004). Nominal associations were also detected between the ASD phenotypes investigated and 5-HT2A, 5-HT4 and 5-HT6 genetic variants.
   Conclusion Our study provides evidence of the contribution of serotonergic variants to IQ, ID and LD in ASD patients. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Hervas, Amaia; Romaris, Patricia; Salgado, Marta; Balmana, Noemi; Guijarro, Silvina] Univ Barcelona, Dept Child Psychiat, Barcelona 08221, Spain.
   [Cormand, Bru; Arranz, Maria J.] Univ Barcelona, Hosp Univ Mutua Terrassa, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona 08221, Spain.
   [Toma, Claudio] Univ Barcelona, Dept Genet, Barcelona 08221, Spain.
   [Cormand, Bru] IBUB, Barcelona, Spain.
   [Toma, Claudio; Cormand, Bru] Vall dHebron Res Inst VHIR, Biomed Network Res Ctr Rare Dis CIBERER, Barcelona, Spain.
   [Ribases, Marta] Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Barcelona, Spain.
   [Bayes, Monica] Hosp St Joan de Deu, CNAG, Barcelona, Spain.
   [Maristany, Marta] Hosp St Joan de Deu, Dept Psychiat, Barcelona, Spain.
   [Arranz, Maria J.] Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain.
   [Arranz, Maria J.] Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England.
RP Arranz, MJ (reprint author), Univ Barcelona, Hosp Univ Mutua Terrassa, Fundacio Docencia & Recerca Mutua Terrassa, C St Antoni 19, Barcelona 08221, Spain.
EM maria.arranz@kcl.ac.uk
RI Toma, Claudio/L-7853-2014
OI Toma, Claudio/0000-0003-3901-7507
FU Instituto de Salud Carlos III, Spain; European Union
   [PIEF-GA-2009-254930]; Fundacio La Marato de TV3 [092010]; Fundacion
   Alicia Koplowitz; Minsterio de Economia y Competitividad, Spain
   [SAF2012-33484]; Agencia de Gestio d'Ajuts Universitaris i de
   Recerca-AGAUR [2009SGR00971]
FX M.R. is a recipient of a Miguel de Servet contract from 'Instituto de
   Salud Carlos III, Spain' and C.T. was supported by the European Union
   (Marie Curie, PIEF-GA-2009-254930). Financial support was received from
   'Fundacio La Marato de TV3' (092010), 'Fundacion Alicia Koplowitz',
   'Minsterio de Economia y Competitividad, Spain' (SAF2012-33484) and
   'Agencia de Gestio d'Ajuts Universitaris i de Recerca-AGAUR'
   (2009SGR00971).
CR Alfimova M V, 2010, Neurosci Behav Physiol, V40, P934, DOI 10.1007/s11055-010-9348-7
   Anderson BM, 2009, NEUROGENETICS, V10, P209, DOI 10.1007/s10048-009-0171-7
   Beitchman JH, 2006, AM J PSYCHIAT, V163, P1103, DOI 10.1176/appi.ajp.163.6.1103
   Bevilacqua L, 2010, NATURE, V468, P1061, DOI 10.1038/nature09629
   Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148
   Calahorro F, 2009, J VIS EXP, V11, P1611
   Coutinho AM, 2004, MOL PSYCHIATR, V9, P264, DOI 10.1038/sj.mp.4001409
   Da Silva Costa-Aze V., 2012, PSYCHOPHARMACOLOGY B, V222, P99
   Hammock E, 2012, J AM ACAD CHILD PSY, V51, P712, DOI 10.1016/j.jaac.2012.04.010
   Hasselbalch SG, 2008, NEUROBIOL AGING, V29, P1830, DOI 10.1016/j.neurobiolaging.2007.04.011
   Hranilovic D, 2010, PSYCHIAT RES, V178, P556, DOI 10.1016/j.psychres.2010.04.007
   Kazek B, 2010, ACTA NEUROBIOL EXP, V70, P232
   King MV, 2008, TRENDS PHARMACOL SCI, V29, P482, DOI 10.1016/j.tips.2008.07.001
   Kistner-Griffin E, 2011, AM J MED GENET B, V156B, P139, DOI 10.1002/ajmg.b.31146
   Levallet G, 2009, PSYCHOPHARMACOLOGY, V202, P125, DOI 10.1007/s00213-008-1283-8
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
   Marchetti E, 2008, NEUROBIOL LEARN MEM, V90, P185, DOI 10.1016/j.nlm.2008.03.010
   Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934
   Orabona GM, 2009, BRAIN RES, V1250, P14, DOI 10.1016/j.brainres.2008.11.007
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Sigmund JC, 2008, BIOL PSYCHOL, V79, P239, DOI 10.1016/j.biopsycho.2008.06.002
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Ucok A, 2007, AM J MED GENET B, V144B, P704, DOI 10.1002/ajmg.b.30463
   Wagner M, 2008, INT J NEUROPSYCHOPH, V11, P1163, DOI 10.1017/S146114570800905X
   Zafeiriou DI, 2009, CURR NEUROPHARMACOL, V7, P150, DOI 10.2174/157015909788848848
NR 26
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0955-8829
EI 1473-5873
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD AUG
PY 2014
VL 24
IS 4
BP 158
EP 163
DI 10.1097/YPG.0000000000000034
PG 6
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AL2BM
UT WOS:000338930800003
PM 24887447
ER

PT J
AU Baghdadli, A
   Pry, R
   Michelon, C
   Rattaz, C
AF Baghdadli, Amaria
   Pry, Rene
   Michelon, Cecile
   Rattaz, Cecile
TI Impact of autism in adolescents on parental quality of life
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Parental quality of life; Autism spectrum disorders; Risk factors;
   Adolescents; Cohort
ID INTELLECTUAL DISABILITIES; SPECTRUM DISORDERS; CHILDREN; STRESS;
   INTERVENTION; CAREGIVERS; PROGRAM; DISEASE; ADULTS; AGE
AB To study the impact of autism spectrum disorders (ASDs) on parental quality of life (QoL) at adolescence using the parental-developmental disorders-quality of life scale (Par-DD-QoL).
   One hundred and fifty-two mothers of adolescents with ASD completed Par-DD-QoL. This scale assesses the following dimensions: emotional, daily disturbance and global QoL. This cross-sectional study uses a subset of data collected at the final time of a follow-up study (EpiTED cohort).
   A polytomic regression identified an increase in aberrant behavior scores as the major independent risk factor for parental QoL. The identified protective factors were the increase in daily living, communication and object cognition scores and a higher number of siblings.
   Those results suggest that there is a negative effect of externalizing behaviors and a protective effect of adaptive skills, communication and object cognition on parental QoL. Study limitations and implications are discussed.
C1 [Baghdadli, Amaria; Pry, Rene; Michelon, Cecile; Rattaz, Cecile] CHRU Montpellier, Ctr Ressources Autisme, F-34295 Montpellier 05, France.
   [Baghdadli, Amaria; Pry, Rene; Michelon, Cecile; Rattaz, Cecile] Univ Montpellier, EA 4556, Lab Epsylon, F-34000 Montpellier, France.
RP Baghdadli, A (reprint author), CHRU Montpellier, Ctr Ressources Autisme, 39 Ave Charles Flahaut, F-34295 Montpellier 05, France.
EM cent-ress-autisme@chu-montpellier.fr
FU Orange Foundation; PHRC
FX This study was supported by a grant from the Orange Foundation and the
   PHRC 1997 and 2007. We are extremely grateful to all the teenagers and
   their families who took part in this study, and the whole EpiTED Team.
CR Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
   Altiere MJ, 2009, J INTELLECT DEV DIS, V34, P142, DOI 10.1080/13668250902845202
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Bachmann C. J., 2010, GMS PSYCHOSOCIAL MED, V7, P1
   Baghdadli A., 2008, PRATIQUES ORG SOINS, V39, P53
   Baghdadli A, 2012, J AUTISM DEV DISORD, V42, P1314, DOI 10.1007/s10803-011-1357-z
   Baghdadli A, 2007, ACTA PSYCHIAT SCAND, V115, P403, DOI 10.1111/j.1600-0447.2006.00898.x
   Beadle-Brown J, 2009, J APPL RES INTELLECT, V22, P380, DOI 10.1111/j.1468-3148.2008.00473.x
   Berdeaux G, 1998, QUAL LIFE RES, V7, P501, DOI 10.1023/A:1008874324258
   Bristol M. M., 1984, EFFECTS AUTISM FAMIL, P289
   Bruchon-Schweitzer M., 2002, PSYCHOL SANTE MODELE, V456
   Cappe E, 2011, QUAL LIFE RES, V20, P1279, DOI 10.1007/s11136-011-9861-3
   DONOVAN AM, 1988, AM J MENT RETARD, V92, P502
   Farnik M, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-151
   Greenley RN, 2009, J PEDIATR PSYCHOL, V34, P129, DOI 10.1093/jpepsy/jsn056
   Hastings RP, 2004, J CHILD PSYCHOL PSYC, V45, P1338, DOI 10.1111/j.1469-7610.2004.00357.x
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Hutton A. M., 2005, FOCUS AUTISM OTHER D, V20, P180, DOI [10.1177/10883576050200030601, DOI 10.1177/10883576050200030601]
   Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017
   Kheir N, 2012, AUTISM, V16, P293, DOI 10.1177/1362361311433648
   Klassen A., 2004, PEDIATRICS, V114, P541, DOI DOI 10.1542/PEDS.2004-0844
   Koegel RL, 1996, J AUTISM DEV DISORD, V26, P347, DOI 10.1007/BF02172479
   Lazarus R. S., 1984, STRESS APPRAISAL COP
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lee GK, 2009, FOCUS AUTISM DEV DIS, V24, P227, DOI 10.1177/1088357609347371
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Meltzer EO, 2001, J ALLERGY CLIN IMMUN, V108, pS45, DOI 10.1067/mai.2001.115566
   Montes Guillermo, 2009, Pediatrics, V124 Suppl 4, pS407, DOI 10.1542/peds.2009-1255L
   Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
   Olsson MB, 2008, J INTELL DISABIL RES, V52, P1102, DOI 10.1111/j.1365-2788.2008.01081.x
   Orsmond GI, 2006, AM J MENT RETARD, V111, P121, DOI 10.1352/0895-8017(2006)111[121:MRQAAA]2.0.CO;2
   Ozonoff S, 1998, J AUTISM DEV DISORD, V28, P25, DOI 10.1023/A:1026006818310
   Parish SL, 2004, MENT RETARD, V42, P413, DOI 10.1352/0047-6765(2004)42<413:EIOCAM>2.0.CO;2
   Preece D, 2007, J AUTISM DEV DISORD, V37, P374, DOI 10.1007/s10803-006-0174-2
   Rattaz C, 2014, AUTISM, V18, P185, DOI 10.1177/1362361312460952
   Raysse P., 2011, THESIS U MONTPELLIER
   Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Seibert J. M., 1982, INFANT MENT HEALTH J, V3, P244, DOI DOI 10.1002/1097-0355(198224)3:4<244::AID-IMHJ2280030406>3.0.CO;2-R
   Shulman B. B., 1985, TEST PRAGMATIC SKILL
   Spann S. J., 2003, FOCUS AUTISM OTHER D, V18, P228, DOI DOI 10.1177/10883576030180040401
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Tunali B, 2002, J AUTISM DEV DISORD, V32, P25, DOI 10.1023/A:1017999906420
   Whittingham K, 2006, RES DEV DISABIL, V27, P364, DOI 10.1016/j.ridd.2005.05.003
   World Health Organisation, 1993, WHO ICD 10 CLASS MEN
   Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
NR 47
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD AUG
PY 2014
VL 23
IS 6
BP 1859
EP 1868
DI 10.1007/s11136-014-0635-6
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA AL6YU
UT WOS:000339280700019
PM 24504623
ER

PT J
AU Domellof, E
   Hedlund, L
   Odman, P
AF Domellof, Erik
   Hedlund, Ludmilla
   Odman, Pia
TI Health-related quality of life of children and adolescents with
   functional disabilities in a northern Swedish county
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Children; Disability; Health-related quality of life; EQ-5D-Y
ID CEREBRAL-PALSY; EQ-5D; DETERMINANTS
AB Health-related quality of life (HRQoL) studies in children and adolescents with disabilities tend to report lower self-reported health than in the typical population. However, reports are not always consistent and HRQoL appears to vary depending on diagnosis, cultural setting and clinical context. The aim of this study was to explore HRQoL in children and adolescents with various disabilities in Vasterbotten County, Sweden.
   A total of 175 children and adolescents [57 girls, 118 boys; mean age 11.7 years (range 7-17 years)] divided into four different diagnostic groups (intellectual disabilities, autism spectrum disorders, movement disorders and hearing disabilities) participated in the study. The EuroQol Five Dimensions Health Questionnaire, Youth version (EQ-5D-Y) was used as HRQoL measure.
   Significant differences in various EQ-5D-Y dimensions between the different diagnostic groups were found, but no differences in overall health status. HRQoL in children and adolescents with hearing disabilities was found similar to the typical child population in Sweden whereas children and adolescents with other diagnoses reported evidently more problems.
   Findings suggest that there is an increased risk for children with functional disabilities other than hearing disabilities in northern Sweden to experience difficulties in various health domains and lowered general health.
C1 [Domellof, Erik; Hedlund, Ludmilla] Umea Univ, Dept Psychol, S-90187 Umea, Sweden.
   [Domellof, Erik] Kolbacken Child Rehabil Ctr, Umea, Sweden.
   [Odman, Pia] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
RP Domellof, E (reprint author), Umea Univ, Dept Psychol, S-90187 Umea, Sweden.
EM erik.domellof@psy.umu.se
FU Umea University
FX This study was supported by a young researcher award from Umea
   University to the first author. We thank the children and their families
   for participating.
CR Arnaud C, 2008, PEDIATRICS, V121, P54, DOI 10.1542/peds.2007-0854
   Burstrom K, 2011, EUR J PUBLIC HEALTH, V21, P178, DOI 10.1093/eurpub/ckq042
   Chaplin JE, 2009, ACTA PAEDIATR, V98, P361, DOI 10.1111/j.1651-2227.2008.01066.x
   Chen HY, 2011, CHILD HEALTH CARE, V40, P311, DOI 10.1080/02739615.2011.617239
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Connolly P., 2007, QUANTITATIVE DATA AN
   Cottenceau H, 2012, EUR CHILD ADOLES PSY, V21, P289, DOI 10.1007/s00787-012-0263-z
   Dahan-Oliel N, 2012, QUAL LIFE RES, V21, P427, DOI 10.1007/s11136-011-0063-9
   Eiser C, 2001, ARCH DIS CHILD, V84, P205, DOI 10.1136/adc.84.3.205
   Fava L, 2009, DISABIL REHABIL, V31, P1943, DOI [10.1080/09638280902874188, 10.3109/09638280902874188]
   Jelsma J, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-72
   Majnemer A, 2007, J PEDIATR-US, V151, P470, DOI 10.1016/j.jpeds.2007.04.014
   Matza LS, 2005, PHARMACOECONOMICS, V23, P777, DOI 10.2165/00019053-200523080-00004
   Meserole RL, 2014, QUAL LIFE RES, V23, P721, DOI 10.1007/s11136-013-0509-3
   Noyes J, 2011, VALUE HEALTH, V14, P1117, DOI 10.1016/j.jval.2011.07.011
   Ravens-Sieberer U, 2010, QUAL LIFE RES, V19, P887, DOI 10.1007/s11136-010-9649-x
   Shikako-Thomas K, 2009, QUAL LIFE RES, V18, P825, DOI 10.1007/s11136-009-9501-3
   Skevington SM, 2002, QUAL LIFE RES, V11, P135, DOI 10.1023/A:1015013312456
   Tsoi W. S. E., 2012, CHILD CARE HLTH DEV, V38, P12
   Umansky AM, 2011, J AM ACAD AUDIOL, V22, P644, DOI 10.3766/jaaa.22.10.3
   White-Koning M, 2007, PEDIATRICS, V120, pE804, DOI 10.1542/peds.2006-3272
   Wille N, 2010, QUAL LIFE RES, V19, P875, DOI 10.1007/s11136-010-9648-y
NR 22
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD AUG
PY 2014
VL 23
IS 6
BP 1877
EP 1882
DI 10.1007/s11136-013-0613-4
PG 6
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA AL6YU
UT WOS:000339280700021
PM 24379137
ER

PT J
AU Poslawsky, IE
   Naber, FBA
   Bakermans-Kranenburg, MJ
   De Jonge, MV
   Van Engeland, H
   Van IJzendoorn, MH
AF Poslawsky, Irina E.
   Naber, Fabienne B. A.
   Bakermans-Kranenburg, Marian J.
   De Jonge, Maretha V.
   Van Engeland, Herman
   Van IJzendoorn, Marinus H.
TI Development of a Video-feedback Intervention to promote Positive
   Parenting for Children with Autism (VIPP-AUTI)
SO ATTACHMENT & HUMAN DEVELOPMENT
LA English
DT Article
DE autism; sensitive parenting; parent-child interaction; early
   intervention; video-feedback
ID SPECTRUM DISORDER; JOINT ATTENTION; MENTAL-RETARDATION; YOUNG-CHILDREN;
   REPETITIVE BEHAVIOR; TYPICAL DEVELOPMENT; PRESCHOOL-CHILDREN;
   ATTACHMENT; PREVALENCE; COMMUNICATION
AB In this paper we describe the development and content of Video-feedback Intervention to promote Positive Parenting for Children with Autism (VIPP-AUTI). VIPP-AUTI is an adapted version of the evidence-based intervention VIPP. The lack of social responsiveness in children with autism often lowers the quality of the parent-child interaction. A wide range of early interventions exist to cope with the disorder. The majority of early interventions for children with autism focus on their deficits of (social) skills, but the number of evidence-based interventions to improve early parent-child interaction patterns is limited. The aim of VIPP-AUTI is to enhance parental sensitivity to children's autistic characteristics, in order to improve child developmental outcome by increased parental support.
C1 [Poslawsky, Irina E.; De Jonge, Maretha V.; Van Engeland, Herman] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Div Neurosci, Utrecht, Netherlands.
   [Naber, Fabienne B. A.; Bakermans-Kranenburg, Marian J.; Van IJzendoorn, Marinus H.] Leiden Univ, Ctr Child & Family Studies, Leiden, Netherlands.
   [Naber, Fabienne B. A.] Erasmus Univ, Sch Pedag & Educ Sci, Rotterdam, Netherlands.
RP Poslawsky, IE (reprint author), Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Div Neurosci, Utrecht, Netherlands.
EM I.E.Uitewaal@umcutrecht.nl
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Attkisson C C, 1982, Eval Program Plann, V5, P233, DOI 10.1016/0149-7189(82)90074-X
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Bakermans-Kranenburg M. J., 2009, ACAMH OCCASIONAL PAP, V29, P47
   Bakermans-Kranenburg MJ, 2003, PSYCHOL BULL, V129, P195, DOI 10.1037/0033-2909.129.2.195
   Bandura A, 1997, SELF EFFICACY EXERCI
   Benjak T, 2009, CROAT MED J, V50, P403, DOI 10.3325/cmj.2009.50.403
   Biringen Z., 2000, ATTACHMENT HUMAN DEV, V2, P256, DOI [10.1080/14616730050085626, DOI 10.1080/14616730050085626]
   Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
   Bruinsma Y, 2004, MENT RETARD DEV D R, V10, P169, DOI 10.1002/mrdd.20036
   Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
   Charman T, 2011, AM J PSYCHIAT, V168, P873, DOI 10.1176/appi.ajp.2011.11060897
   Couturier JL, 2005, J AM ACAD CHILD PSY, V44, P815, DOI 10.1097/01.chi.0000166377.22651.87
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   de Brey H, 1983, Eval Program Plann, V6, P395, DOI 10.1016/0149-7189(83)90018-6
   De Wilde EF, 2005, EUR ADDICT RES, V11, P157, DOI 10.1159/000086396
   Doussard-Roosevelt JA, 2003, DEV PSYCHOPATHOL, V15, P277, DOI 10.1017/S0954579403000154
   Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
   Erba HW, 2000, AM J ORTHOPSYCHIAT, V70, P82, DOI 10.1037/h0087826
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
   Juffer F., 2014, ROUTLEDGE HDB ATTACH
   Juffer F., 2008, PROMOTING POSITIVE P
   KASARI C, 1988, J ABNORM CHILD PSYCH, V16, P45, DOI 10.1007/BF00910499
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x
   Laud RB, 2009, BEHAV MODIF, V33, P520, DOI 10.1177/0145445509346729
   Lord C, 2011, NATURE, V474, P166, DOI 10.1038/474166a
   Makrygianni MK, 2010, RES AUTISM SPECT DIS, V4, P577, DOI 10.1016/j.rasd.2010.01.014
   Matson JL, 2011, RES DEV DISABIL, V32, P693, DOI 10.1016/j.ridd.2010.11.012
   McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
   McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
   McDuffie AS, 2006, AUTISM, V10, P288, DOI 10.1177/1362361306063287
   Mesibov GB, 2010, J AUTISM DEV DISORD, V40, P570, DOI 10.1007/s10803-009-0901-6
   Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61
   Mundy P, 2000, DEV PSYCHOBIOL, V36, P325, DOI 10.1002/(SICI)1098-2302(200005)36:4<325::AID-DEV7>3.0.CO;2-F
   Naber FBA, 2007, J ABNORM CHILD PSYCH, V35, P899, DOI 10.1007/s10802-007-9142-3
   Naber FBA, 2008, J AUTISM DEV DISORD, V38, P857, DOI 10.1007/s10803-007-0454-5
   Naber FBA, 2007, J AUTISM DEV DISORD, V37, P1123, DOI 10.1007/s10803-006-0255-2
   New York State Department of Health Clinical Practice Guideline, 1999, QUICK REF GUID PAR P
   Noens ILJ, 2005, J COMMUN DISORD, V38, P123, DOI 10.1016/j.jcomdis.2004.06.002
   Oono IP, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009774.pub2
   Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
   Peters-Scheffer N, 2011, RES AUTISM SPECT DIS, V5, P60, DOI 10.1016/j.rasd.2010.03.011
   Rice CE, 2011, AM FAM PHYSICIAN, V83, P515
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Rutgers AH, 2007, J ABNORM CHILD PSYCH, V35, P859, DOI 10.1007/s10802-007-9139-y
   Schwichtenberg A, 2007, J INTELL DISABIL RES, V51, P598, DOI 10.1111/j.1365-2788.2006.00940.x
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   Van Engeland H., 2009, RUTTERS CHILD ADOLES, P759, DOI [10.1002/9781444300895, DOI 10.1002/9781444300895.CH46]
   van IJzendoorn MH, 2007, CHILD DEV, V78, P597, DOI 10.1111/j.1467-8624.2007.01016.x
   Van Zeijl J, 2006, J CONSULT CLIN PSYCH, V74, P994, DOI 10.1037/0022-006X.74.6.994
   Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
   Wallace KS, 2010, J CHILD PSYCHOL PSYC, V51, P1300, DOI 10.1111/j.1469-7610.2010.02308.x
   Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
   Wieder S, 2003, AUTISM, V7, P425, DOI 10.1177/1362361303007004008
   Yaman A, 2010, SOC PSYCH PSYCH EPID, V45, P505, DOI 10.1007/s00127-009-0097-2
NR 62
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1461-6734
EI 1469-2988
J9 ATTACH HUM DEV
JI Attach. Hum. Dev.
PD AUG
PY 2014
VL 16
IS 4
SI SI
BP 343
EP 355
DI 10.1080/14616734.2014.912487
PG 13
WC Psychology, Developmental
SC Psychology
GA AK9CS
UT WOS:000338725700004
PM 24972103
ER

PT J
AU Miyachi, T
   Nakai, A
   Tani, I
   Ohnishi, M
   Nakajima, S
   Tsuchiya, KJ
   Matsumoto, K
   Tsujii, M
AF Miyachi, Taishi
   Nakai, Akio
   Tani, Iori
   Ohnishi, Masafumi
   Nakajima, Shunji
   Tsuchiya, Kenji J.
   Matsumoto, Kaori
   Tsujii, Masatsugu
TI Evaluation of Motor Coordination in Boys with High-Functioning Pervasive
   Developmental Disorder Using the Japanese Version of the Developmental
   Coordination Disorder Questionnaire
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE High-functioning pervasive developmental disorder (HFPDD); Developmental
   coordination disorder (DCD); Developmental coordination disorder
   questionnaire (DCDQ); Motor coordination dysfunction; Autism diagnostic
   interview-revised (ADI-R); Questionnaire
ID AUTISM SPECTRUM DISORDERS; ASPERGER-SYNDROME; DIAGNOSTIC INTERVIEW;
   CHILDREN; CLUMSINESS; METAANALYSIS; IMPAIRMENTS; ADOLESCENTS;
   PERCEPTIONS; RELIABILITY
AB Children with high-functioning pervasive developmental disorder (HFPDD) often have motor coordination dysfunction. However, there is no assessment tool for screening developmental coordination disorder (DCD) in Japan, which makes it difficult to evaluate the actual motor impairments of children with HFPDD. We evaluated the motor coordination function of 54 school-age boys with HFPDD using the Japanese version of the Developmental Coordination Disorder Questionnaire (DCDQ-J). We subsequently assessed the relationship between DCDQ-J scores and the results of the Japanese version of the Autism Diagnostic Interview-Revised (ADI-R) of 48 boys. The total and subscale DCDQ-J scores of the boys with HFPDD were significantly lower than the population means in the same grade: 37.0 % were below 2 standard deviations for the total score, 38.9 % for control during movement, 26.0 % for fine motor/handwriting, and 37.0 % for general coordination. Furthermore, the scores of Qualitative Abnormalities in Communication in the ADI-R were negatively correlated with control during movement, fine motor/handwriting, and total scores in the DCDQ-J. This study is the first to show Japanese children with HFPDD frequently exhibit considerably poor motor coordination according to the DCDQ-J. The screening or assessment of motor dysfunction in HFPDD using assessment tools such as the DCDQ could aid the development of interventions for these underestimated problems in Japan.
C1 [Miyachi, Taishi] Nagoya Cent Rehabil Ctr, Dept Pediat, Nagoya, Aichi, Japan.
   [Nakai, Akio] Hyogo Childrens Sleep & Dev Med Res Ctr, Nishi Ku, Kobe, Hyogo 6512181, Japan.
   [Tani, Iori] Tokai Gakuen Univ, Sch Humanities, Nagoya, Aichi, Japan.
   [Ohnishi, Masafumi] Univ Fukui, Fac Educ & Reg Studies, Fukui 910, Japan.
   [Nakajima, Shunji; Tsuchiya, Kenji J.; Matsumoto, Kaori] Hamamatsu Univ Sch Med, Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 4313192, Japan.
   [Tsujii, Masatsugu] Chukyo Univ, Sch Contemporary Sociol, Nagoya, Aichi, Japan.
RP Nakai, A (reprint author), Hyogo Childrens Sleep & Dev Med Res Ctr, Nishi Ku, Akebono Cho 1070, Kobe, Hyogo 6512181, Japan.
EM anakai.kodomo@gmail.com
CR Aman MG, 2009, RES DEV DISABIL, V30, P386, DOI 10.1016/j.ridd.2008.07.004
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Attwood T., 1998, ASPERGERS SYNDROME G, P13
   Bart O, 2013, RES DEV DISABIL, V34, P1922, DOI 10.1016/j.ridd.2013.03.015
   Blank R, 2012, DEV MED CHILD NEUROL, V54, P54, DOI 10.1111/j.1469-8749.2011.04171.x
   Braathen G, 1997, ACTA PAEDIATR, V86, P372, DOI 10.1111/j.1651-2227.1997.tb09025.x
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Enticott PG, 2009, DEV MED CHILD NEUROL, V51, P787, DOI 10.1111/j.1469-8749.2009.03270.x
   Farkas Z, 2010, SEIZURE-EUR J EPILEP, V19, P173, DOI 10.1016/j.seizure.2010.01.013
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
   GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
   Henderson SE, 1992, MOVEMENT ASSESSMENT
   Japanese WISC-III Publication Committee, 1998, NIH WISC 3 CHIN KENS
   Missiuna Cheryl, 2006, Can J Occup Ther, V73, P7
   Kokubun M., 2014, INT J DEV D IN PRESS
   Kopp S, 2010, RES DEV DISABIL, V31, P350, DOI 10.1016/j.ridd.2009.09.017
   Kushki A, 2011, J AUTISM DEV DISORD, V41, P1706, DOI 10.1007/s10803-011-1206-0
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Loubinoux I, 2005, NEUROIMAGE, V27, P299, DOI 10.1016/j.neuroimage.2004.12.023
   Murdoch BE, 2010, CORTEX, V46, P858, DOI 10.1016/j.cortex.2009.07.018
   Nakai A, 2011, RES DEV DISABIL, V32, P1615, DOI 10.1016/j.ridd.2011.02.012
   Piek JP, 2006, HUM MOVEMENT SCI, V25, P65, DOI 10.1016/j.humov.2005.10.011
   Polatajko Helene J, 2005, Semin Pediatr Neurol, V12, P250, DOI 10.1016/j.spen.2005.12.007
   Rivard LM, 2007, BRIT J EDUC PSYCHOL, V77, P633, DOI 10.1348/000709906X159879
   Skinner RA, 2001, HUM MOVEMENT SCI, V20, P73, DOI 10.1016/S0167-9457(01)00029-X
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   Stephenson EA, 2008, CHILD CARE HLTH DEV, V34, P335, DOI 10.1111/j.1365-2214.2007.00805.x
   Sturm H, 2004, DEV MED CHILD NEUROL, V46, P444, DOI 10.1017/S0012162204000738
   Tsuchiya KJ, 2013, J AUTISM DEV DISORD, V43, P643, DOI 10.1007/s10803-012-1606-9
   Vakalopoulos C, 2013, CEREBELLUM, V12, P212, DOI 10.1007/s12311-012-0416-0
   Wilson BN, 2009, PHYS OCCUP THER PEDI, V29, P182, DOI 10.1080/01942630902784761
   Wilson BN, 2000, AM J OCCUP THER, V54, P484, DOI 10.5014/ajot.54.5.484
NR 36
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD AUG
PY 2014
VL 26
IS 4
BP 403
EP 413
DI 10.1007/s10882-014-9377-1
PG 11
WC Rehabilitation
SC Rehabilitation
GA AK9XZ
UT WOS:000338783200003
ER

PT J
AU Meadan, H
   Stoner, JB
   Angell, ME
   Daczewitz, ME
   Cheema, J
   Rugutt, JK
AF Meadan, Hedda
   Stoner, Julia B.
   Angell, Maureen E.
   Daczewitz, Marcus E.
   Cheema, Jehanzeb
   Rugutt, John K.
TI Do You See a Difference? Evaluating Outcomes of a Parent-Implemented
   Intervention
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Social validity; Social-communication skills; Parent-implemented
   intervention
ID SOCIAL VALIDITY; BEHAVIOR; CHILDREN; VALIDATION; LANGUAGE; AUTISM
AB The Parent-Implemented Communication Strategies (PiCS) project resulted in the development of an intervention package aimed at enhancing the social communication skills of young children with disabilities and limited expressive language. While the outcomes of the PiCS project seem to be positive, a thorough and comprehensive assessment of social validity was warranted. Wolf (Journal of Applied Behavior Analysis, 11, 203-214, 1978) contended that interventions should be assessed not only for effectiveness but also for social validity. This study of social validity addressed the question, "Was the PiCS project socially valid from an expert perspective?" Our expert evaluators were recruited from three groups: (a) parents of young children with disabilities, (b) early childhood special education teachers, and (c) speech language pathologists who worked with young children with disabilities. Each evaluator viewed video clips of parent-child interactions from pre- and post-intervention sessions, in random order, and completed a questionnaire about parent and child behaviors. The overall findings provided support for the social validity of the PiCS project. Further discussion that examines differences in the ratings of the groups of evaluators and implications for research and practice is provided.
C1 [Meadan, Hedda] Univ Illinois, Dept Special Educ, Champaign, IL 61820 USA.
   [Stoner, Julia B.; Angell, Maureen E.; Daczewitz, Marcus E.] Illinois State Univ, Dept Special Educ, Normal, IL 61790 USA.
   [Cheema, Jehanzeb] Univ Illinois, Bur Educ Res, Champaign, IL 61820 USA.
   [Rugutt, John K.] Illinois State Univ, Dept Educ Adm & Fdn, Normal, IL 61790 USA.
RP Meadan, H (reprint author), Univ Illinois, Dept Special Educ, 1310 S Sixth St, Champaign, IL 61820 USA.
EM meadan@illinois.edu; jbstone@ilstu.edu; meangel@ilstu.edu;
   mdaczewitz@gmail.com; jrcheema@illinois.edu; jkrugut@ilstu.edu
CR Bruder MB, 2010, EXCEPT CHILDREN, V76, P339
   Dunlap G, 2006, J EARLY INTERVENTION, V28, P81, DOI 10.1177/105381510602800201
   Foster SL, 1999, J CONSULT CLIN PSYCH, V67, P308, DOI 10.1037//0022-006X.67.3.308
   Halle J. W., 1982, J ASS SEVERELY HANDI, V7, P29
   Hancock TB, 2006, TREATMENT LANGUAGE D, P203
   HART B, 1975, J APPL BEHAV ANAL, V8, P411, DOI 10.1901/jaba.1975.8-411
   HEMMETER ML, 1994, J EARLY INTERVENTION, V18, P269
   Kashinath S, 2006, J SPEECH LANG HEAR R, V49, P466, DOI 10.1044/1092-4388(2006/036)
   KAZDIN AE, 1977, BEHAV MODIF, V1, P427, DOI 10.1177/014544557714001
   Meadan H, 2009, TOP EARLY CHILD SPEC, V29, P90, DOI 10.1177/0271121409337950
   Meadan H, 2014, FOCUS AUTISM DEV DIS, V29, P95, DOI 10.1177/1088357613517504
   Meadan H., 2013, PARENT PERSPEC UNPUB
   Rogers-Warren A. K., 1985, TEACHING FUNCTIONAL, P63
   SCHWARTZ IS, 1991, J APPL BEHAV ANAL, V24, P189, DOI 10.1901/jaba.1991.24-189
   Statistical Package for the Social Sciences (SPSS), 2013, SPSS BAS 22 0 WIND U
   Stoner JB, 2012, EDUC ASSESS EVAL ACC, V24, P57, DOI 10.1007/s11092-011-9136-0
   STOREY K, 1991, J SPEC EDUC, V25, P352
   Tabachnick G. B., 2007, USING MULTIVARIATE S
   Turan Y., 2011, YOUNG EXCEPTIONAL CH, V14, P13, DOI 10.1177/1096250611415812
   WOLF MM, 1978, J APPL BEHAV ANAL, V11, P203, DOI 10.1901/jaba.1978.11-203
   Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 21
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD AUG
PY 2014
VL 26
IS 4
BP 415
EP 430
DI 10.1007/s10882-014-9376-2
PG 16
WC Rehabilitation
SC Rehabilitation
GA AK9XZ
UT WOS:000338783200004
ER

PT J
AU Berquist, KL
   Charlop, MH
AF Berquist, Kari L.
   Charlop, Marjorie H.
TI Teaching Parents of Children with Autism to Evaluate Interventions
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Evaluation; Autism; Parent education; Empirically validated
   interventions; Complementary and alternative interventions; Evidenced
   based practices
ID SPECTRUM DISORDERS; ALTERNATIVE MEDICINE; YOUNG-CHILDREN; COMPLEMENTARY;
   STRESS; PERCEPTIONS; DIAGNOSIS; EDUCATION; FAMILIES; SPEECH
AB Children with autism are participating in a variety of interventions that are believed to be effective by their parents; however, a majority of these interventions are not empirically supported. In this study, we assessed the efficacy of a parent education program to teach parents of children with autism to evaluate their child's interventions. Parents' acquisition, generalization, and maintenance of evaluation behaviors were examined. Additionally, we looked at parents' understanding of information regarding evaluating interventions and decision-making patterns regarding treatments in comparison to controls. A multiple baseline design across parent participants was used to assess parents' evaluation skills. After completion of a parent education program, parents increased in their evaluative behaviors relative to individual baseline measures. In addition, parents in the experimental group increased their understanding of information regarding evaluating interventions and empirically based decisions regarding treatments in comparison to controls.
C1 [Berquist, Kari L.] Claremont Grad Univ, Div Behav & Org Sci, Claremont, CA USA.
   [Charlop, Marjorie H.] Claremont Mckenna Coll, Dept Psychol, Claremont, CA 91711 USA.
   [Berquist, Kari L.] Stanford Univ, Med Ctr, Lucile Packard Childrens Hosp Stanford, Stanford, CA 94305 USA.
RP Berquist, KL (reprint author), Stanford Univ, Med Ctr, Lucile Packard Childrens Hosp Stanford, 401 Quarry Rd, Stanford, CA 94305 USA.
EM kbe@stanford.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baden H. P., 2000, PEDIATRICS, V105, P1, DOI 10.1542/peds.105.2.e18
   Benson P, 2008, AUTISM, V12, P47, DOI 10.1177/1362361307085269
   BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6
   Bussing R., 2002, PSYCHIAT SERV, V53, P1196, DOI 10.1176/appi.ps.53.9.1096
   Campbell M, 1996, J AM ACAD CHILD PSY, V35, P134, DOI 10.1097/00004583-199602000-00005
   Carinci G. J., 2007, THESIS CALIFORNIA SC
   CHARLOP MH, 1991, J APPL BEHAV ANAL, V24, P747, DOI 10.1901/jaba.1991.24-747
   Christon LM, 2010, RES AUTISM SPECT DIS, V4, P249, DOI 10.1016/j.rasd.2009.09.013
   COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
   Sandler AD, 2001, PEDIATRICS, V107, P1221
   DeMyer M., 1979, PARENTS CHILDREN AUT
   Erguner-Tekinalp B, 2004, INT J ADV COUNS, V26, P257, DOI DOI 10.1023/B:ADCO.0000035529.92256.0D
   Feinberg E., 2000, FOCUS AUTISM OTHER D, V15, P130, DOI [10.1177/108835760001500301, DOI 10.1177/108835760001500301]
   Frea W. D., 1999, J POSIT BEHAV INTERV, V1, P112, DOI 10.1177/109830079900100205
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Goin-kochel R. P., 2006, J DEV DISABILITIES, V12, P41
   Goin-Kochel RP, 2007, RES AUTISM SPECT DIS, V1, P195, DOI 10.1016/j.rasd.2006.08.006
   Golnik AE, 2009, J AUTISM DEV DISORD, V39, P996, DOI 10.1007/s10803-009-0714-7
   Green G., 1996, BEHAV INTERVENTION Y, P15
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Green VA, 2007, J DEV PHYS DISABIL, V19, P91, DOI 10.1007/s10882-007-9035-y
   Handelman J. S., 1986, ED DEV DISABLED M NE
   Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
   Harrington JW, 2006, J DEV BEHAV PEDIATR, V27, pS156, DOI 10.1097/00004703-200604002-00014
   Hayden A. H., 1977, EARLY CHILDHOOD ED E, P208
   Herbert J. D., 2002, SCI REV MENTAL HLTH, V1, P23
   HOLROYD J, 1976, AM J MENT DEF, V80, P431
   Horner RH, 2005, EXCEPT CHILDREN, V71, P165
   Hurvitz EA, 2003, DEV MED CHILD NEUROL, V45, P364, DOI 10.1017/S0012162203000707
   Interactive Autism Network (IAN), 2009, IAN RES FIND TREATM
   Smith T, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P45
   JACOBSON JW, 1995, AM PSYCHOL, V50, P750, DOI 10.1037//0003-066X.50.9.750
   Kabot S, 2003, PROF PSYCHOL-RES PR, V34, P26, DOI 10.1037/0735-7028.34.1.26
   Kane K., 2005, PITTSBURGH POSTGAZET
   Kanner L, 1943, NERV CHILD, V2, P217
   Kay S, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P265
   KOEGEL RL, 1983, J CONSULT CLIN PSYCH, V51, P683
   KOEGEL RL, 1978, J APPL BEHAV ANAL, V11, P95, DOI 10.1901/jaba.1978.11-95
   KORAN ML, 1971, J EDUC PSYCHOL, V62, P219, DOI 10.1037/h0031142
   LANGE DN, 1971, J EDUC RES, V65, P151
   LASKI KE, 1988, J APPL BEHAV ANAL, V21, P391, DOI 10.1901/jaba.1988.21-391
   Mackintosh VH, 2012, FOCUS AUTISM DEV DIS, V27, P51, DOI 10.1177/1088357611423542
   Malmberg D. B., 2007, THESIS CLAREMONT GRA
   Metz B, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P237
   Moses D. R., 2002, J POSIT BEHAV INTERV, V2, P40, DOI [10.1177/109830070000200106, DOI 10.1177/109830070000200106]
   National Autism Center (NAC), 2009, NAT STAND PROJ
   National Institute of Health (NIH), 2012, FUND FACTS
   Pacheco M., 2000, J BEHAV ED, V10, P205, DOI [10.1023/A:1012295615144, DOI 10.1023/A:1012295615144]
   Santarelli G., 2001, J POSIT BEHAV INTERV, V3, P120, DOI 10.1177/109830070100300209
   Schreck KA, 2008, BEHAV INTERVENT, V23, P201, DOI 10.1002/bin.264
   Schreibman L., 2005, SCI FICTION AUTISM
   Schreibman L., 1983, BEHAV THERAPIST, V6, P107
   Schreibman L, 2001, BEHAV THER, V32, P619, DOI 10.1016/S0005-7894(01)80012-5
   Scott J. M., 1993, THESIS U OTTAWA OTTA
   Simpson R. L., 2005, AUTISM SPECTRUM DISO
   Smith GJ, 1999, PERCEPT MOTOR SKILL, V89, P951, DOI 10.2466/PMS.89.7.951-965
   Smith T, 2000, BEHAV INTERVENT, V15, P83, DOI 10.1002/(SICI)1099-078X(200004/06)15:2<83::AID-BIN47>3.0.CO;2-W
   Smith TB, 2001, AM J ORTHOPSYCHIAT, V71, P257, DOI 10.1037//0002-9432.71.2.257
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
   Strain P. S., 1987, ZERO 3, V7, P7
   WALLS RT, 1981, BEHAV MODIF, V5, P61, DOI 10.1177/014544558151005
NR 63
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD AUG
PY 2014
VL 26
IS 4
BP 451
EP 472
DI 10.1007/s10882-014-9374-4
PG 22
WC Rehabilitation
SC Rehabilitation
GA AK9XZ
UT WOS:000338783200006
ER

PT J
AU Cevikaslan, A
   Evans, DW
   Dedeoglu, C
   Kalaca, S
   Yazgan, Y
AF Cevikaslan, Ahmet
   Evans, David W.
   Dedeoglu, Ceyda
   Kalaca, Sibel
   Yazgan, Yanki
TI A Cross-Sectional Survey of Repetitive Behaviors and Restricted
   Interests in A Typically Developing Turkish Child Population
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE Compulsive-like behavior; Ritualistic behavior; Repetitive behavior;
   Restricted interest; Childhood Routines Inventory
ID OBSESSIVE-COMPULSIVE DISORDER; AUTISM SPECTRUM DISORDERS;
   YOUNG-CHILDREN; RITUALS; SYMPTOMS; INFANTS; ASSOCIATION; INSIGHTS;
   PHOBIAS; NUMBER
AB This study examined compulsive-like behaviors (CLBs) which are higher-order types of Repetitive Behaviors And Restricted Interests (RBRIs) in typically developing children in Turkey. Caregivers of 1,204 children between 8 and 72 months were interviewed with Childhood Routines Inventory (CRI) by trained interviewers in a cross-sectional survey. Factor analysis of the CRI revealed two factor structures comprising "just right behaviors" and "repetitive/sensory sensitivity behaviors". CLB frequency peaked at 2-4 years with declines after age four. In contrast to the previous CRI studies reporting no gender difference, CLBs were more common in males in 12-23 and 48-59 month age groups on both total CLB frequency and repetitive/sensory sensitivity behaviors. Also ages of onsets for CRI items were somewhat later than reported in other samples. Our findings supported the findings of the previous CRI studies while also revealing new perspectives in need of further investigation.
C1 [Cevikaslan, Ahmet; Yazgan, Yanki] Marmara Univ, Sch Med, Child & Adolescent Psychiat Dept, Istanbul, Turkey.
   [Evans, David W.] Bucknell Univ, Dept Psychol, Lewisburg, PA 17837 USA.
   [Evans, David W.] Geisinger Bucknell Autism & Dev Med Ctr, Lewisburg, PA USA.
   [Dedeoglu, Ceyda] Bogazici Univ, Dept Psychol, Istanbul, Turkey.
   [Kalaca, Sibel] Marmara Univ, Sch Med, Prevent Med & Publ Hlth Dept, Istanbul, Turkey.
   [Yazgan, Yanki] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA.
RP Yazgan, Y (reprint author), Marmara Univ, Sch Med, Child & Adolescent Psychiat Dept, Gullu Sokak,4,Ic Levent, Istanbul, Turkey.
EM yanki.yazgan@gmail.com
CR Allison C, 2008, J AUTISM DEV DISORD, V38, P1414, DOI 10.1007/s10803-007-0509-7
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Anagnostou E, 2011, J NEUROPSYCH CLIN N, V23, P332, DOI 10.1176/appi.neuropsych.23.3.332
   Arnott B, 2010, J DEV BEHAV PEDIATR, V31, P223, DOI 10.1097/DBP.0b013e3181d5a2ad
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Bolton D, 2009, J CHILD PSYCHOL PSYC, V50, P1139, DOI 10.1111/j.1469-7610.2009.02094.x
   Campbell SB, 1997, ADV CLIN CHILD PSYCH, V19, P1
   CATTELL RB, 1966, MULTIVAR BEHAV RES, V1, P245, DOI 10.1207/s15327906mbr0102_10
   Challman TD, 2012, INSAR M
   Clarke RA, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.75
   Cohen J., 1988, STAT POWER ANAL BEHA, P284
   Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947
   Dar R, 2012, J BEHAV THER EXP PSY, V43, P679, DOI 10.1016/j.jbtep.2011.09.008
   DeLoache JS, 2007, DEV PSYCHOL, V43, P1579, DOI 10.1037/0012-1649.43.6.1579
   Evans D, 2011, CHILD PSYCHIAT HUM D, V42, P12, DOI 10.1007/s10578-010-0198-x
   Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925
   Evans DW, 2004, BRAIN COGNITION, V55, P220, DOI 10.1016/s0278-2626(03)00274-4
   Evans DW, 2000, J ADULT DEV, V7, P49, DOI 10.1023/A:1009555102447
   Evans DW, 2011, BEHAV BRAIN RES, V224, P174, DOI 10.1016/j.bbr.2011.05.025
   Evans DW, 2002, CHILD PSYCHIAT HUM D, V33, P43, DOI 10.1023/A:1016516205827
   Evans DW, 1999, CHILD PSYCHIAT HUM D, V29, P261, DOI 10.1023/A:1021392931450
   FIESE BH, 1993, J MARRIAGE FAM, V55, P633, DOI 10.2307/353344
   Fiske AP, 1997, J NERV MENT DIS, V185, P211, DOI 10.1097/00005053-199704000-00001
   Gesell A., 1974, INFANT CHILD CULTURE
   Glenn S, 2012, EUR J DEV PSYCHOL, V9, P614, DOI 10.1080/17405629.2011.639139
   Guzzetta A, 2010, DEV MED CHILD NEUROL, V52, P767, DOI 10.1111/j.1469-8749.2009.03497.x
   HORN JL, 1965, PSYCHOMETRIKA, V30, P179, DOI 10.1007/BF02289447
   Johnson KE, 2004, COGNITIVE DEV, V19, P325, DOI 10.1016/j.cogdev.2004.03.001
   Judge PG, 2011, BEHAV BRAIN RES, V222, P57, DOI 10.1016/j.bbr.2011.03.016
   KAISER HF, 1960, EDUC PSYCHOL MEAS, V20, P141, DOI 10.1177/001316446002000116
   Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
   Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x
   Leckman JF, 1999, ACTA PSYCHIAT SCAND, V100, P1, DOI 10.1111/j.1600-0447.1999.tb10951.x
   Leekam S, 2007, J CHILD PSYCHOL PSYC, V48, P1131, DOI 10.1111/j.1469-7610.2007.01778.x
   Leekam SR, 2011, PSYCHOL BULL, V137, P562, DOI 10.1037/a0023341
   Lewis M, 2009, J NEURODEV DISORD, V1, P114, DOI 10.1007/s11689-009-9019-6
   Lienard P, 2006, AM ANTHROPOL, V108, P814, DOI 10.1525/aa.2006.108.4.814
   Marks I. M., 1987, FEARS PHOBIAS RITUAL
   Moss J, 2009, J AUTISM DEV DISORD, V39, P572, DOI 10.1007/s10803-008-0655-6
   Pauls David L, 2010, Dialogues Clin Neurosci, V12, P149
   Peleg-Popko O, 2003, J ANXIETY DISORD, V17, P667, DOI 10.1016/S0887-6185(02)00235-9
   Pietrefesa AS, 2007, BRAIN COGNITION, V65, P36, DOI 10.1016/j.bandc.2006.02.007
   Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
   SELIGMAN ME, 1971, BEHAV THER, V2, P307, DOI 10.1016/S0005-7894(71)80064-3
   SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420
   Smith CL, 2004, DEV PSYCHOL, V40, P29, DOI 10.1037/0012-1649.40.1.29
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x
   THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X
   Tregay J, 2009, BRIT J DEV PSYCHOL, V27, P283, DOI 10.1348/026151008X299737
   TUIK, 2000, REP CENS
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   Watkins M. W., 2000, MONTE CARLO PCA PARA
   Werner H., 1948, COMP PSYCHOL MENTAL
   World Health Organization, 1993, INT CLASS MENT BEH D
   Zohar AH, 2001, J ABNORM CHILD PSYCH, V29, P121, DOI 10.1023/A:1005231912747
NR 56
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-398X
EI 1573-3327
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD AUG
PY 2014
VL 45
IS 4
BP 472
EP 482
DI 10.1007/s10578-013-0417-3
PG 11
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AK3KU
UT WOS:000338323400010
PM 24242356
ER

PT J
AU McDonald, CA
   Volker, MA
   Lopata, C
   Toomey, JA
   Thomeer, ML
   Lee, GK
   Lipinski, AM
   Dua, EH
   Schiavo, AM
   Bain, F
   Nelson, AT
AF McDonald, Christin A.
   Volker, Martin A.
   Lopata, Christopher
   Toomey, Jennifer A.
   Thomeer, Marcus L.
   Lee, Gloria K.
   Lipinski, Alanna M.
   Dua, Elissa H.
   Schiavo, Audrey M.
   Bain, Fabienne
   Nelson, Andrew T.
TI VMI-VI and BG-II KOPPITZ-2 for Youth With HFASDs and Typical Youth
SO JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
LA English
DT Article
DE motor skills; visual-motor; Bender-Gestalt-II; KOPPITZ-2; Developmental
   Test of Visual-Motor Integration-6th ed.; high-functioning autism
   spectrum disorders
ID BENDER-GESTALT-II; MOTOR; CHILDREN; PERFORMANCE; ADJUSTMENT
AB The visual-motor skills of 90 youth with high-functioning autism spectrum disorders (HFASDs) and 51 typically developing (TD) youth were assessed using the Beery-Buktenica Developmental Test of Visual-Motor Integration, Sixth Edition (VMI-VI) and Koppitz Developmental Scoring System for the Bender-Gestalt Test-Second Edition (KOPPITZ-2). Within-group comparisons (for both samples) yielded substantive mean differences between the KOPPITZ-2 composite and VMI-VI composite, Visual Perception and Motor Coordination sections of the VMI-VI, and VMI-VI composite and either VMI-VI supplemental tests. Between-group differences were assessed in a matched subsample of 33 participants from each group. The HFASD group scored significantly lower than the TD group on test sections requiring greater motor ability (i.e., VMI-VI composite, VMI-VI Motor Coordination, KOPPITZ-2 composite, and Bender-Gestalt Visual-Motor Test-Second Edition [BG-II]). Correlations between the KOPPITZ-2 composite and VMI-VI composite were .56 for the HFASD and .36 for the TD samples.
C1 [McDonald, Christin A.] Nationwide Childrens Hosp, Columbus, OH USA.
   [Volker, Martin A.; Lee, Gloria K.; Lipinski, Alanna M.; Dua, Elissa H.; Bain, Fabienne; Nelson, Andrew T.] SUNY Buffalo, Buffalo, NY 14260 USA.
   [Lopata, Christopher; Thomeer, Marcus L.] Canisius Coll, Buffalo, NY 14208 USA.
   [Toomey, Jennifer A.; Schiavo, Audrey M.] Summit Educ Resources, Getzville, NY USA.
RP McDonald, CA (reprint author), Nationwide Childrens Hosp, Ctr Autism Spectrum Disorders, 187 W Schrock Rd, Westerville, OH 43081 USA.
EM Christin.Mcdonald@nationwidechildrens.org
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Archer RP, 2000, ASSESSMENT, V7, P227, DOI 10.1177/107319110000700303
   Bart O, 2007, INFANT CHILD DEV, V16, P597, DOI 10.1002/icd.514
   Beery K, 2010, BEERY BUKTENICA DEV
   Brannigan G. G., 2003, BENDER VISUAL MOTOR
   Brannigan GG, 2006, AM J ORTHOPSYCHIAT, V76, P10, DOI 10.1037/0002-9432.76.1.10
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   DEMERS ST, 1981, PERCEPT MOTOR SKILL, V53, P863
   KNOFF HM, 1986, PSYCHOL SCHOOLS, V23, P247, DOI 10.1002/1520-6807(198607)23:3<247::AID-PITS2310230303>3.0.CO;2-Y
   Koppitz EM, 1975, BENDER GESTALT TEST
   Kushki A, 2011, J AUTISM DEV DISORD, V41, P1706, DOI 10.1007/s10803-011-1206-0
   Lopata C, 2007, PERCEPT MOTOR SKILL, V104, P1183, DOI 10.2466/PMS.104.4.1183-1192
   Reynolds C., 2000, ENCY SPECIAL ED
   Reynolds C. R., 2007, KOPPITZ DEV SCORING
   SHAPIRO SK, 1994, J PSYCHOEDUC ASSESS, V12, P254, DOI 10.1177/073428299401200304
   TELLEGEN A, 1967, J CONSULT PSYCHOL, V31, P499, DOI 10.1037/h0024963
   Volker MA, 2010, J PSYCHOEDUC ASSESS, V28, P187, DOI 10.1177/0734282909348216
   Wechsler D., 2003, WECHSLER INTELLIGENC
NR 18
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0734-2829
EI 1557-5144
J9 J PSYCHOEDUC ASSESS
JI J. Psychoeduc. Assess.
PD AUG
PY 2014
VL 32
IS 5
BP 379
EP 389
DI 10.1177/0734282913514351
PG 11
WC Psychology, Educational
SC Psychology
GA AK1OY
UT WOS:000338185600001
ER

PT J
AU Foti, F
   Mazzone, L
   Menghini, D
   De Peppo, L
   Federico, F
   Postorino, V
   Baumgartner, E
   Valeri, G
   Petrosini, L
   Vicari, S
AF Foti, F.
   Mazzone, L.
   Menghini, D.
   De Peppo, L.
   Federico, F.
   Postorino, V.
   Baumgartner, E.
   Valeri, G.
   Petrosini, L.
   Vicari, S.
TI Learning by observation in children with autism spectrum disorder
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Autism spectrum disorder; imitation; observational learning; sequential
   learning
ID MIRROR-NEURON SYSTEM; WORKING-MEMORY; IMITATION IMPAIRMENTS; REPETITIVE
   BEHAVIOR; COGNITIVE CONTROL; SOCIAL COGNITION; BASAL GANGLIA; MOTOR;
   DYSFUNCTION; FMRI
AB Background. Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Learning by observation requires specific skills such as attending, imitating and understanding contingencies. Individuals with autism spectrum disorder (ASD) exhibit deficits in these skills.
   Method. The performance of 20 ASD children was compared with that of a group of typically developing (TD) children matched for chronological age (CA), IQ and gender on tasks of learning of a visuomotor sequence by observation or by trial and error. Acquiring the correct sequence involved three phases: a detection phase (DP), in which participants discovered the correct sequence and learned how to perform the task; an exercise phase (EP), in which they reproduced the sequence until performance was error free; and an automatization phase (AP), in which by repeating the error-free sequence they became accurate and speedy.
   Results. In the DP, ASD children were impaired in detecting a sequence by trial and error only when the task was proposed as first, whereas they were as efficient as TD children in detecting a sequence by observation. In the EP, ASD children were as efficient as TD children. In the AP, ASD children were impaired in automatizing the sequence. Although the positive effect of learning by observation was evident, ASD children made a high number of imitative errors, indicating marked tendencies to hyperimitate.
   Conclusions. These findings demonstrate the imitative abilities of ASD children although the presence of imitative errors indicates an impairment in the control of imitative behaviours.
C1 [Foti, F.; Petrosini, L.] Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy.
   [Foti, F.; Petrosini, L.] IRCCS Fdn Santa Lucia, Rome, Italy.
   [Mazzone, L.; Menghini, D.; De Peppo, L.; Postorino, V.; Valeri, G.; Vicari, S.] Bambino Gesu Pediat Hosp, Child Neuropsychiat Unit, Dept Neurosci, Rome, Italy.
   [Federico, F.; Baumgartner, E.] Univ Roma La Sapienza, Dept Dev & Social Psychol, I-00185 Rome, Italy.
RP Foti, F (reprint author), Univ Roma La Sapienza, Dept Psychol, Via Marsi 78, I-00185 Rome, Italy.
EM francesca.foti@uniroma1.it
CR Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
   Allen G, 2004, BIOL PSYCHIAT, V56, P269, DOI 10.1016/j.biophsych.2004.06.005
   American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Bandura A., 1977, SOCIAL LEARNING THEO
   Beery KE, 2000, BEERY BUKTENICA DEV
   Bernier R, 2007, BRAIN COGNITION, V64, P228, DOI 10.1016/j.bandc.2007.03.004
   Biancardi A, 1997, PSICHIATRIA INFANZIA, V64, P73
   Bird G, 2005, J EXP PSYCHOL HUMAN, V31, P262, DOI 10.1037/0096-1523.31.2.262
   Buccino G, 2001, EUR J NEUROSCI, V13, P400, DOI 10.1046/j.1460-9568.2001.01385.x
   Chambers CD, 2007, J NEUROPHYSIOL, V98, P3638, DOI 10.1152/jn.00685.2007
   Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x
   Clarke HF, 2008, J NEUROSCI, V28, P10972, DOI 10.1523/JNEUROSCI.1521-08.2008
   Cook J, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00175
   Cook J, 2014, PSYCHOL MED, V44, P731, DOI 10.1017/S0033291713001335
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Donnelly Jessica L, 2009, J Prev Interv Community, V37, P170, DOI 10.1080/10852350902975926
   Ersche KD, 2011, BIOL PSYCHIAT, V70, P754, DOI 10.1016/j.biopsych.2011.06.033
   Esseily R, 2010, INFANT BEHAV DEV, V33, P695, DOI 10.1016/j.infbeh.2010.07.017
   Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8
   Foti F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053782
   Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
   Grandin T, 2009, PHILOS T R SOC B, V364, P1437, DOI 10.1098/rstb.2008.0297
   Grandin T., 1995, THINKING PICTURES
   Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
   Hamilton AFDC, 2008, Q J EXP PSYCHOL, V61, P101, DOI 10.1080/17470210701508798
   Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252
   Herbert J, 2006, INFANT BEHAV DEV, V29, P136, DOI 10.1016/j.infbeh.2005.08.002
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Kana RK, 2011, NEUROSCI BIOBEHAV R, V35, P894, DOI 10.1016/j.neubiorev.2010.10.007
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   Kokkinaki T, 2000, J REPROD INFANT PSYC, V18, P173
   Kunda M, 2011, J AUTISM DEV DISORD, V41, P1157, DOI 10.1007/s10803-010-1137-1
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   Leekam SR, 1998, J CHILD PSYCHOL PSYC, V39, P951, DOI 10.1017/S0021963098003035
   Leighton J, 2008, NEUROPSYCHOLOGIA, V46, P1041, DOI 10.1016/j.neuropsychologia.2007.11.013
   Lord C., 2005, AUTISM DIAGNOSTIC OB
   Luna B, 2002, NEUROLOGY, V59, P834
   Marsh L, 2013, CURR BIOL, V23, pR266, DOI 10.1016/j.cub.2013.02.036
   Martin LA, 2010, EUR J NEUROSCI, V31, P544, DOI 10.1111/j.1460-9568.2009.07073.x
   Martineau J, 2010, BRAIN RES, V1320, P168, DOI 10.1016/j.brainres.2010.01.035
   Meltzoff AN, 2009, SCIENCE, V325, P284, DOI 10.1126/science.1175626
   MELTZOFF AN, 1995, DEV PSYCHOL, V31, P838, DOI 10.1037/0012-1649.31.5.838
   MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
   Meltzoff AN, 2003, PHILOS T R SOC B, V358, P491, DOI 10.1098/rstb.2002.1261
   Menghini D, 2011, NEUROPSYCHOLOGIA, V49, P1996, DOI 10.1016/j.neuropsychologia.2011.03.029
   Menghini D, 2006, NEUROIMAGE, V33, P1218, DOI 10.1016/j.neuroimage.2006.08.024
   Middleton FA, 2000, BRAIN RES REV, V31, P236, DOI 10.1016/S0165-0173(99)00040-5
   Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795
   Mundy P, 1997, J AUTISM DEV DISORD, V27, P653, DOI 10.1023/A:1025802832021
   Nadel J, 2011, AUTISM, V15, P421, DOI 10.1177/1362361310386508
   Nadel J., 2002, IMITATIVE MIND DEV E, P42, DOI 10.1017/CBO9780511489969.003
   Nadel J, 1998, IMITATION INFANCY
   Neuhaus E, 2010, CLIN PSYCHOL REV, V30, P733, DOI 10.1016/j.cpr.2010.05.007
   Nobile M, 2007, CONNERS RATING SCALE
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   Ozonoff S, 2001, J AUTISM DEV DISORD, V31, P257, DOI 10.1023/A:1010794902139
   Pellicano E, 2012, AUTISM RES TREATMENT, V2012
   Petrosini L, 2007, NEUROSCIENTIST, V13, P335, DOI 10.1177/1073858407300687
   Ramachandran VS, 2006, SCI AM, V295, P62
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Russell J., 1997, AUTISM EXECUTIVE DIS
   RUTTER M, 1974, PSYCHOL MED, V4, P147
   Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
   Seidler RD, 2005, EXP BRAIN RES, V165, P114, DOI 10.1007/s00221-005-2284-z
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Shic F, 2011, BRAIN RES, V1380, P246, DOI 10.1016/j.brainres.2010.11.074
   Shih P, 2010, NEUROPSYCHOLOGIA, V48, P2931, DOI 10.1016/j.neuropsychologia.2010.05.035
   Silk TJ, 2006, AM J PSYCHIAT, V163, P1440, DOI 10.1176/appi.ajp.163.8.1440
   Soulieres I, 2011, NEUROPSYCHOLOGIA, V49, P848, DOI 10.1016/j.neuropsychologia.2011.01.027
   Southgate V, 2008, TRENDS COGN SCI, V12, P225, DOI 10.1016/j.tics.2008.03.005
   Spengler S, 2010, SOC NEUROSCI-UK, V5, P401, DOI 10.1080/17470911003687905
   Stuss D. T., 2002, PRINCIPLES FRONTAL L
   Swick D, 2011, NEUROIMAGE, V56, P1655, DOI 10.1016/j.neuroimage.2011.02.070
   Taylor BA, 2012, BEHAV MODIF, V36, P341, DOI 10.1177/0145445512443981
   Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
   Torriero S, 2011, J COGNITIVE NEUROSCI, V23, P338, DOI 10.1162/jocn.2010.21471
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Verhoeven JS, 2010, NEURORADIOLOGY, V52, P3, DOI 10.1007/s00234-009-0583-y
   Wechsler D., 1991, MANUAL WECHSLER INTE
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
NR 89
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD AUG
PY 2014
VL 44
IS 11
BP 2437
EP 2447
DI 10.1017/S003329171300322X
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AK1TL
UT WOS:000338199200018
ER

PT J
AU Hollocks, MJ
   Howlin, P
   Papadopoulos, AS
   Khondoker, M
   Simonoff, E
AF Hollocks, Matthew J.
   Howlin, Patricia
   Papadopoulos, Andrew S.
   Khondoker, Mizanur
   Simonoff, Emily
TI Differences in HPA-axis and heart rate responsiveness to psychosocial
   stress in children with autism spectrum disorders with and without
   co-morbid anxiety
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Autistic disorder; Cortisol; Developmental disorders; Emotion; Mood
   disorders
ID SALIVARY CORTISOL-LEVELS; PERVASIVE DEVELOPMENTAL DISORDERS;
   SCHOOL-AGE-CHILDREN; SOCIAL PHOBIA; PSYCHIATRIC-DISORDERS; AUTONOMIC
   FLEXIBILITY; REACTIVITY; ADOLESCENTS; PREVALENCE; POPULATION
AB Children and adolescents with autism spectrum disorder (ASD) have much higher rates of anxiety disorders relative to their typically developing peers. However, there have been few attempts to investigate what physiological parameters may be associated with this elevated rate of anxiety. Therefore, this study investigated the physiological correlates of anxiety in ASD, with a focus on whether measures of heart rate and cortisol responsiveness to psychosocial stress differentiate those participants with ASD with and without a co-occurring anxiety disorder. A total of 75 male participants aged 10-16 years with normal intellectual ability underwent a psychosocial stress test. The participants included healthy controls (n = 23), ASD only (ASD; n = 20) and ASD with a comorbid anxiety disorder (ASDanx; n = 32). Heart rate, heart rate variability and salivary cortisol were compared by fitting a piecewise regression model to examine baseline levels and change over time within and between the rest, stress and recovery phases of the stress test. The ASDanx group had different response patterns from both the ASD and control groups. The ASDanx group was characterized by a blunted cortisol and heart rate response to psychosocial stress. Furthermore, in the ASDanx group, reduced heart rate and cortisol responsiveness were significantly related to increased anxiety symptoms. This is the first study to report a possible physiological basis for co-occurring anxiety disorders in children and adolescents with ASD. It is possible that a non-adaptive physiological response to psychosocial stress may be related to the high prevalence of co-occurring anxiety disorders in people with ASD. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Hollocks, Matthew J.; Simonoff, Emily] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England.
   [Howlin, Patricia] Kings Coll London, Inst Psychiat, Dept Psychol, London SE5 8AF, England.
   [Howlin, Patricia] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2141, Australia.
   [Papadopoulos, Andrew S.] Kings Coll London, Inst Psychiat, Dept Psychol Med, London SE5 8AF, England.
   [Khondoker, Mizanur] Kings Coll London, Inst Psychiat, Dept Biostat, London SE5 8AF, England.
   [Simonoff, Emily] Biomed Res Ctr Mental Hlth, London SE5 8AF, England.
RP Hollocks, MJ (reprint author), Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, POB 85,16 De Crespigny Pk, London SE5 8AF, England.
EM matthew.hollocks@kcl.ac.uk
RI Khondoker, Mizanur/A-9860-2011
FU Biomedical Research Centre (BRC) in Mental Health [PCCKASA]; South
   London and Maudsley Charitable Funds
FX This project was supported by the Biomedical Research Centre (BRC) in
   Mental Health, code: PCCKASA.Funding for equipment and saliva analyses
   was provided by a grant from the South London and Maudsley Charitable
   Funds.
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   Anderson ER, 2009, J ANXIETY DISORD, V23, P18, DOI 10.1016/j.janxdis.2008.03.011
   Angold A, 2000, J AM ACAD CHILD PSY, V39, P39, DOI 10.1097/00004583-200001000-00015
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Beaton EA, 2006, PERS INDIV DIFFER, V41, P1217, DOI 10.1016/j.paid.2006.02.0230
   BEIDEL DC, 1991, J AM ACAD CHILD PSY, V30, P545, DOI 10.1097/00004583-199107000-00003
   Corbett BA, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-13
   Corominas M, 2012, Atten Defic Hyperact Disord, V4, P63, DOI 10.1007/s12402-012-0075-5
   Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Davidson RJ, 2000, BIOL PSYCHIAT, V47, P85, DOI 10.1016/S0006-3223(99)00222-X
   de Rooij SR, 2010, PSYCHONEUROENDOCRINO, V35, P866, DOI 10.1016/j.psyneuen.2009.11.011
   Friedman BH, 2007, BIOL PSYCHOL, V74, P185, DOI 10.1016/j.biopsycho.2005.08.009
   Furlan PM, 2001, BIOL PSYCHIAT, V50, P254, DOI 10.1016/S0006-3223(00)01126-4
   Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
   Jansen LMC, 2003, NEUROPSYCHOPHARMACOL, V28, P582, DOI 10.1038/sj.npp.1300046
   Jansen LMC, 2006, J AUTISM DEV DISORD, V36, P891, DOI 10.1007/s10803-006-0124-z
   Kirschbaum C, 2009, PSYCHONEUROENDOCRINO, V34, P32, DOI 10.1016/j.psyneuen.2008.08.024
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   KOLMAN BS, 1976, AM J CARDIOL, V37, P1041, DOI 10.1016/0002-9149(76)90421-5
   Kramer M, 2012, J ABNORM CHILD PSYCH, V40, P95, DOI 10.1007/s10802-011-9548-9
   Lang P. J., 1985, ANXIETY ANXIETY DISO, P131
   Lanni KE, 2012, AUTISM, V16, P123, DOI 10.1177/1362361311425916
   Levine TP, 2012, RES AUTISM SPECT DIS, V6, P177, DOI 10.1016/j.rasd.2011.04.003
   Lombardi E, 1997, CEPR, V1, P335, DOI 10.1023/A:1009964906233
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809
   Martel FL, 1999, DEPRESS ANXIETY, V10, P25, DOI 10.1002/(SICI)1520-6394(1999)10:1<25::AID-DA4>3.0.CO;2-O
   Mathewson KJ, 2011, AUTISM RES, V4, P98, DOI 10.1002/aur.176
   Mauss I. B., 2003, PSYCHOPHYSIOLOGY
   Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Ming X, 2005, BRAIN DEV-JPN, V27, P509, DOI 10.1016/j.braindev.2005.01.003
   Mondelli V, 2010, SCHIZOPHR RES, V116, P234, DOI 10.1016/j.schres.2009.08.013
   MONTANO N, 1994, CIRCULATION, V90, P1826
   Morris MC, 2012, J AFFECT DISORDERS, V143, P223, DOI 10.1016/j.jad.2012.05.059
   Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
   Petrowski K, 2010, PSYCHONEUROENDOCRINO, V35, P414, DOI 10.1016/j.psyneuen.2009.08.003
   Porges S. W., 1992, BIOL PSYCHOL
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schmidt-Reinwald A, 1999, LIFE SCI, V64, P1653, DOI 10.1016/S0024-3205(99)00103-4
   Schmitz J, 2011, J CHILD PSYCHOL PSYC, V52, P1203, DOI 10.1111/j.1469-7610.2011.02417.x
   Schniering CA, 2000, CLIN PSYCHOL REV, V20, P453, DOI 10.1016/S0272-7358(99)00037-9
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Shin LM, 2010, NEUROPSYCHOPHARMACOL, V35, P169, DOI 10.1038/npp.2009.83
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
   Staufenbiel S. M., 2013, PSYCHONEUROENDOCRINO
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Task Force of the European Society of Cardiology and North American Society of Pacing and Electrophysiology, 1996, CIRCULATION, V93, P1043, DOI DOI 10.1161/01.CIR.93.5.1043
   Thayer J. F., 2012, NEUROSCI BIOBEHAV RE
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Van Hecke A. V., 2009, CHILD DEV, V4, P1118
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   van West D, 2008, J AFFECT DISORDERS, V111, P281, DOI 10.1016/j.jad.2008.03.006
   Watson L. R., 2012, J AUTISM DEV DISORD
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Yehuda R, 2011, ENDOCRINOLOGY, V152, P4496, DOI 10.1210/en.2011-1218
NR 60
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2014
VL 46
BP 32
EP 45
DI 10.1016/j.psyneuen.2014.04.004
PG 14
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AK4RZ
UT WOS:000338413100004
PM 24882156
ER

PT J
AU Miller, M
   Chukoskie, L
   Zinni, M
   Townsend, J
   Trauner, D
AF Miller, M.
   Chukoskie, L.
   Zinni, M.
   Townsend, J.
   Trauner, D.
TI Dyspraxia, motor function and visual-motor integration in autism
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Dyspraxia; Motor; Visual-motor integration; Eye movement;
   Cerebellum
ID DEVELOPMENTAL COORDINATION DISORDER; SPECTRUM DISORDERS;
   ASPERGER-SYNDROME; INFANTILE-AUTISM; YOUNG-CHILDREN; BASAL GANGLIA;
   EXECUTIVE FUNCTION; INTERNAL-MODELS; EYE-MOVEMENTS; CEREBELLUM
AB This project assessed dyspraxia in high-functioning school aged children with autism with a focus on Ideational Praxis. We examined the association of specific underlying motor function including eye movement with ideational dyspraxia (sequences of skilled movements) as well as the possible role of visual-motor integration in dyspraxia. We found that compared to IQ-, sex- and age-matched typically developing children, the children with autism performed significantly worse on: Ideational and Buccofacial praxis; a broad range of motor tests, including measures of simple motor skill, timing and accuracy of saccadic eye movements and motor coordination; and tests of visual-motor integration. Impairments in individual children with autism were heterogeneous in nature, although when we examined the praxis data as a function of a qualitative measure representing motor timing, we found that children with poor motor timing performed worse on all praxis categories and had slower and less accurate eye movements while those with regular timing performed as well as typical children on those same tasks. Our data provide evidence that both motor function and visual-motor integration contribute to dyspraxia. We suggest that dyspraxia in autism involves cerebellar mechanisms of movement control and the integration of these mechanisms with cortical networks implicated in praxis. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Miller, M.] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA.
   [Chukoskie, L.] Univ Calif San Diego, Inst Neural Computat, La Jolla, CA 92093 USA.
   [Zinni, M.; Townsend, J.; Trauner, D.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
RP Townsend, J (reprint author), Univ Calif San Diego, Dept Neurosci, 9500 Gilman Dr,MC-0959, La Jolla, CA 92093 USA.
EM jtownsend@ucsd.edu
FU NIH [2 T35 HL 7491-31]; NINDS [P50-NS22343, R21-NS070296]; NSF [SMA
   1041755]
FX This study was funded by the NIH 2 T35 HL 7491-31 (MM), NINDS
   P50-NS22343 (DT), NINDS R21-NS070296 (JT) and NSF SMA 1041755 TDLC
   Science of Learning Center (LC). Tyler Brocklehurst (Institute for
   Neural Computation, UCSD) and Carin Rojas (School of Medicine,
   Northwestern University) who served as trained raters scoring praxis
   videos.
CR Abell F, 1999, NEUROREPORT, V10, P1647, DOI 10.1097/00001756-199906030-00005
   Bair WN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040932
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Baron-Cohen S, 2005, ANNU REV NEUROSCI, V28, P109, DOI 10.1146/annurev.neuro.27.070203.144137
   BAUMAN ML, 1991, PEDIATRICS, V87, P791
   Bauman ML, 1997, INT REV NEUROBIOL, V41, P367
   Beery K, 2006, HE BEERY BUKTENICA D
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Bhanpuri NH, 2013, J NEUROSCI, V33, P14301, DOI 10.1523/JNEUROSCI.0784-13.2013
   Bhat AN, 2012, INFANT BEHAV DEV, V35, P838, DOI 10.1016/j.infbeh.2012.07.019
   Bhat AN, 2011, PHYS THER, V91, P1116, DOI 10.2522/ptj.20100294
   Bostan AC, 2013, TRENDS COGN SCI, V17, P241, DOI 10.1016/j.tics.2013.03.003
   Bruininks R. H., 1978, BRUININKS OSERETSKY
   Chukoskie L, 2013, INT REV NEUROBIOL, V113, P207, DOI 10.1016/B978-0-12-418700-9.00007-1
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Courchesne E, 1999, NEUROLOGY, V52, P1106
   COURCHESNE E, 1994, LANCET, V343, P63, DOI 10.1016/S0140-6736(94)90923-7
   Crippa A, 2013, J AUTISM DEV DISORD, V43, P841, DOI 10.1007/s10803-012-1623-8
   DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777
   DeMeyer M K, 1972, J Autism Child Schizophr, V2, P264
   DENCKLA MB, 1985, PSYCHOPHARMACOL BULL, V21, P773
   Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270
   DEWEY D, 1993, BRAIN COGNITION, V23, P203, DOI 10.1006/brcg.1993.1055
   Dixon W, 1990, BMDP STAT SOFTWARE M, V1-2
   Dowd AM, 2012, J AUTISM DEV DISORD, V42, P1539, DOI 10.1007/s10803-011-1385-8
   Dowell LR, 2009, NEUROPSYCHOLOGY, V23, P563, DOI 10.1037/a0015640
   Downey R, 2012, PEDIATR PHYS THER, V24, P2, DOI 10.1097/PEP.0b013e31823db95f
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Esposito G, 2009, BRAIN DEV-JPN, V31, P131, DOI 10.1016/j.braindev.2008.04.005
   Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
   Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x
   GHAZIUDDIN M, 1994, J INTELL DISABIL RES, V38, P519
   Gibbs J, 2007, ARCH DIS CHILD, V92, P534, DOI 10.1136/adc.2005.088054
   Goldberg MC, 2002, NEUROPSYCHOLOGIA, V40, P2039, DOI 10.1016/S0028-3932(02)00059-3
   Haas RH, 1996, J CHILD NEUROL, V11, P84
   HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163
   Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
   Henderson SE, 1992, MOVEMENT ASSESSMENT
   Hughes C, 1996, J AUTISM DEV DISORD, V26, P99, DOI 10.1007/BF02276237
   Ivry Richard B., 2003, Neural Plasticity, V10, P141, DOI 10.1155/NP.2003.141
   Izawa J, 2012, AUTISM RES, V5, P124, DOI 10.1002/aur.1222
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Johnson Beth P, 2012, Front Integr Neurosci, V6, P99, DOI 10.3389/fnint.2012.00099
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Kanner L, 1943, NERV CHILD, V2, P217
   Keehn B, 2012, HUM BRAIN MAPP, V34, P2524
   Kourkoulou A, 2013, AUTISM RES, V6, P177, DOI 10.1002/aur.1274
   Kuhn G, 2010, PSYCHOL SCI, V21, P1487, DOI 10.1177/0956797610383435
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
   Lane A, 2012, PEDIATR PHYS THER, V24, P21, DOI 10.1097/PEP.0b013e31823e071a
   Lewis JD, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00845
   Lewis JD, 2013, HUM BRAIN MAPP, V34, P1685, DOI 10.1002/hbm.22018
   LINCOLN AJ, 1988, J AUTISM DEV DISORD, V18, P505, DOI 10.1007/BF02211870
   Lloyd M, 2013, AUTISM, V17, P133, DOI 10.1177/1362361311402230
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   MacNeil LK, 2012, NEUROPSYCHOLOGY, V26, P165, DOI 10.1037/a0026955
   Manto M, 2012, CEREBELLUM, V11, P457, DOI 10.1007/s12311-011-0331-9
   Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
   Maski KP, 2011, CURR OPIN PEDIATR, V23, P609, DOI 10.1097/MOP.0b013e32834c9282
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   Minshew NJ, 1999, NEUROLOGY, V52, P917
   Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
   Mosconi MW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063709
   Mosconi MW, 2009, PSYCHOL MED, V39, P1559, DOI 10.1017/S0033291708004984
   Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437
   Mostofsky SH, 2011, NEUROSCIENTIST, V17, P437, DOI 10.1177/1073858410392381
   Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
   Price KJ, 2012, RES AUTISM SPECT DIS, V6, P857, DOI 10.1016/j.rasd.2011.11.007
   Rinehart NJ, 2006, DEV MED CHILD NEUROL, V48, P819, DOI 10.1017/S0012162206001769
   Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
   Rogers SJ, 1996, CHILD DEV, V67, P2060, DOI 10.2307/1131609
   Rommelse NNJ, 2008, BRAIN COGNITION, V68, P391, DOI 10.1016/j.bandc.2008.08.025
   ROSENHALL U, 1988, J LARYNGOL OTOL, V102, P435, DOI 10.1017/S0022215100105286
   Schlerf JE, 2007, CEREBELLUM, V6, P221, DOI 10.1080/14734220701370643
   Schmahmann JD, 2008, CORTEX, V44, P1037, DOI 10.1016/j.cortex.2008.04.004
   Schmahmann JD, 2004, J COMP NEUROL, V478, P248, DOI 10.1002/cne.20286
   Smith IM, 2007, COGN NEUROPSYCHOL, V24, P679, DOI 10.1080/02643290701669703
   Steinman KJ, 2010, J CHILD NEUROL, V25, P71, DOI 10.1177/0883073809342591
   Stoodley CJ, 2012, NEUROIMAGE, V59, P1560, DOI 10.1016/j.neuroimage.2011.08.065
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
   Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
   Townsend J, 2010, HANDBOOK OF MEDICAL NEUROPSYCHOLOGY: APPLICATIONS OF COGNITIVE NEUROSCIENCE, P165, DOI 10.1007/978-1-4419-1364-7_10
   van der Geest JN, 2001, BIOL PSYCHIAT, V50, P614, DOI 10.1016/S0006-3223(01)01070-8
   VILENSKY JA, 1981, ARCH NEUROL-CHICAGO, V38, P646
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weimer AK, 2001, J DEV BEHAV PEDIATR, V22, P92
   Weiss Michael J, 2013, Front Integr Neurosci, V7, P33, DOI 10.3389/fnint.2013.00033
   Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   WOLPERT DM, 1995, SCIENCE, V269, P1880, DOI 10.1126/science.7569931
   Wolpert DM, 1998, TRENDS COGN SCI, V2, P338, DOI 10.1016/S1364-6613(98)01221-2
NR 95
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD AUG 1
PY 2014
VL 269
BP 95
EP 102
DI 10.1016/j.bbr.2014.04.011
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AJ7GY
UT WOS:000337866400014
PM 24742861
ER

PT J
AU Zhang-James, Y
   Yang, L
   Middleton, FA
   Yang, LN
   Patak, J
   Faraone, SV
AF Zhang-James, Yanli
   Yang, Li
   Middleton, Frank A.
   Yang, Lina
   Patak, Jameson
   Faraone, Stephen V.
TI Autism-related behavioral phenotypes in an inbred rat substrain
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE WKY; Substrain; Social interaction; Ultrasonic vocalization; Inbred rat
ID SPONTANEOUSLY HYPERTENSIVE-RAT; MICE MUS-MUSCULUS; ANIMAL-MODEL;
   ULTRASONIC VOCALIZATIONS; SPECTRUM DISORDERS; RODENT MODELS; WKY RATS;
   CHILDREN; DEPRESSION; ATTENTION
AB Behavioral and genetic differences among Wistar-Kyoto (WKY) rats from different vendors and different breeders have long been observed, but generally overlooked. In our prior work, we found that two closely related WKY substrains, the WKY/NCrl and WKY/NHsd rats, differ in a small percentage of their genome which appeared to be highly enriched for autism risk genes. Although both substrains have been used widely in studies of hypertension, attention deficit/hyperactivity disorder (ADHD) and depression, they have not been tested for any autism-related behavioral phenotypes. Furthermore, these two substrains have often been used interchangeably in previous studies; no study has systematically examined the phenotypic differences that could be attributed by their small yet potentially meaningful genetic differences. In this paper we compared these two substrains on a battery of neurobehavioral tests. Although two substrains were similar in locomotor activity, WKY/NCrl rats were significantly different from WKY/NHsd rats in the elevated plus maze test, as well as measures of social interaction and ultrasonic vocalization. These strains were also compared with Sprague Dawley (SD) rats, a common outbred strain, and spontaneous hypertensive rats (SHR), an inbred rat model for ADHD and hypertension, which were derived from the same ancestor strain as the WKY strains. Our behavioral findings suggest that WKY/NCrl rats may be useful as a model autism spectrum disorders due to their lower social interest, lower ultrasonic vocalization and higher anxiety levels when WKY/NHsd rats are used as the control strain. Given the small genetic difference between the two inbred substrains, future studies to identify the exact gene and sequence variants that differ between the two may be useful for identifying the genetic mechanisms underlying these behaviors. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Zhang-James, Yanli; Middleton, Frank A.; Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
   [Middleton, Frank A.; Yang, Lina; Patak, Jameson; Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA.
   [Yang, Li] Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China.
RP Faraone, SV (reprint author), SUNY Upstate Med Univ, 750 E Adams St, Syracuse, NY 13210 USA.
EM Zhangy@upstate.edu; yangli_pkuimh@bjmu.edu.cn; middletf@upstate.edu;
   yanglin@upstate.edu; patakj@upstate.edu; sfaraone@childpsychresearch.org
FU NIH [R01MH066877]; NARSAD Young Investigator Award
FX We thank Dr. Valerie Bolivar for helpful comments on the manuscript.
   This study was supported by NIH Grant R01MH066877 to Dr. Stephen Faraone
   and a NARSAD Young Investigator Award to Dr. Yanli Zhang-James.
CR Abbott A, 2004, NATURE, V428, P464, DOI 10.1038/428464a
   Adriani W, 2003, NEUROSCI BIOBEHAV R, V27, P639, DOI 10.1016/j.neubiorev.2003.08.007
   Anthony LG, 2013, DEV PSYCHOPATHOL, V25, P643, DOI 10.1017/S0954579413000072
   Atanur SS, 2013, CELL, V154, P691, DOI 10.1016/j.cell.2013.06.040
   Bambini V, 2011, BRAIN RES, V1408, P8, DOI 10.1016/j.brainres.2011.06.015
   Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007
   Braw Y, 2008, BEHAV BRAIN RES, V193, P94, DOI 10.1016/j.bbr.2008.04.026
   Brodkin ES, 2007, BEHAV BRAIN RES, V176, P53, DOI 10.1016/j.bbr.2006.06.025
   Coury Daniel L, 2012, Pediatrics, V130 Suppl 2, pS160, DOI 10.1542/peds.2012-0900N
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Detera-Wadleigh SD, 2011, PHARMACOPSYCHIATRY, V44, pS35, DOI 10.1055/s-0031-1275275
   Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
   Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348
   Green SA, 2010, J AUTISM DEV DISORD, V40, P1495, DOI 10.1007/s10803-010-1007-x
   Hlavacova Natasa, 2006, Endocr Regul, V40, P113
   HOFER MA, 1978, DEV PSYCHOBIOL, V11, P495, DOI 10.1002/dev.420110513
   Hurwitz R, 2012, COCHRANE DB SYST REV, V3
   Knutson B, 2002, PSYCHOL BULL, V128, P961, DOI 10.1037//0033-2909.128.6.961
   Liao P, 2010, PFLUG ARCH EUR J PHY, V460, P353, DOI 10.1007/s00424-009-0753-0
   MAGGIO JC, 1985, J COMP PSYCHOL, V99, P420, DOI 10.1037//0735-7036.99.4.420
   Meneses A, 2011, REV NEUROSCIENCE, V22, P365, DOI 10.1515/RNS.2011.024
   Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
   Moy SS, 2008, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082
   Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
   Myles BS, 2001, EDUC TRAIN MENT RET, V36, P304
   Neumann ID, 2008, J NEUROENDOCRINOL, V20, P858, DOI 10.1111/j.1365-2826.2008.01726.x
   NYBY J, 1983, BEHAV NEURAL BIOL, V39, P128, DOI 10.1016/S0163-1047(83)90722-7
   OVERSTREET DH, 1993, NEUROSCI BIOBEHAV R, V17, P51, DOI 10.1016/S0149-7634(05)80230-1
   Pare WP, 1997, PHYSIOL BEHAV, V62, P643, DOI 10.1016/S0031-9384(97)00191-1
   PARE WP, 1994, PHYSIOL BEHAV, V55, P433, DOI 10.1016/0031-9384(94)90097-3
   Petit-Demouliere B, 2005, PSYCHOPHARMACOLOGY, V177, P245, DOI 10.1007/s00213-004-2048-7
   Sadamatsu Miyuki, 2006, Congenital Anomalies, V46, P1, DOI 10.1111/j.1741-4520.2006.00094.x
   Sagvolden T, 2005, BIOL PSYCHIAT, V57, P1239, DOI 10.1016/j.biopsych.2005.02.002
   Saito Y, 2013, SOCIAL COGN AFFECT N
   Sasson NJ, 2013, J AUTISM DEV DISORD, V44, P584
   Sasson NJ, 2008, AUTISM RES, V1, P31, DOI 10.1002/aur.4
   Schwarting R, 2010, E NEUROFORUM, V1, P71
   SEWELL GD, 1970, NATURE, V227, P410, DOI 10.1038/227410a0
   Smith A.S., 2013, BIOL PSYCHIAT
   Toth I, 2013, CELL TISSUE RES, V354, P107, DOI 10.1007/s00441-013-1636-4
   Ung D, 2013, NEUROPSYCHIATRY, V3
   Wohr M, 2013, BEHAV BRAIN RES, V251, P5, DOI 10.1016/j.bbr.2013.05.047
   Yang M., 2013, FRONT BEHAV NEUROSCI, V19, P159, DOI DOI 10.3389/FNBEH
   Zhang-James Y, 2013, PHYSIOL GENOMICS, V45, P528, DOI 10.1152/physiolgenomics.00002.2013
NR 44
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD AUG 1
PY 2014
VL 269
BP 103
EP 114
DI 10.1016/j.bbr.2014.04.035
PG 12
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AJ7GY
UT WOS:000337866400015
PM 24780868
ER

PT J
AU Tostanoski, A
   Lang, R
   Raulston, T
   Carnett, A
   Davis, T
AF Tostanoski, Amy
   Lang, Russell
   Raulston, Tracy
   Carnett, Amarie
   Davis, Tonya
TI Voices from the past: Comparing the rapid prompting method and
   facilitated communication
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Rapid Prompting Method; facilitated communication; intervention;
   communication; autism; pseudoscience
ID TEACHING JOINT ATTENTION; AUTISM; CHILDREN; PSEUDOSCIENCE; INTERVENTION;
   SCIENCE; GAZE
AB Objective: This article briefly reviews the history and damage caused by facilitated communication (FC) and highlights the parallels between FC and the Rapid Prompting Method (RPM).
   Background: FC involves a therapist (or facilitator) supporting the hand of a person with autism while a message is typed on a letter board. FC is widely acknowledged to be a pseudoscientific, unsafe, and unethical treatment for people with autism. RPM is a more recent intervention for people with autism that involves the facilitator holding and moving the letter board while the individual with autism moves their own hand. Those who espouse the perceived benefits of FC and RPM make strikingly similar claims of hidden intelligence and extraordinary communication abilities in people with autism following treatment.
   Conclusion: Clients, proponents, and practitioners of RPM should demand scientific validation of RPM in order to ensure the safety of people with disabilities that are involved with RPM.
C1 [Tostanoski, Amy; Lang, Russell; Raulston, Tracy; Carnett, Amarie] Texas State Univ San Marcos, Clin Autism Res Evaluat & Support, San Marcos, TX 78666 USA.
   [Lang, Russell] Texas State Univ San Marcos, Dept Curriculum & Instruct, San Marcos, TX 78666 USA.
   [Davis, Tonya] Baylor Univ, Dept Educ Psychol, Waco, TX 76798 USA.
RP Lang, R (reprint author), Texas State Univ San Marcos, Dept Curriculum & Instruct, 601 Univ Dr, San Marcos, TX 78666 USA.
EM russlang@txstate.edu
CR Biklen D, 1991, DISABILITY HANDICAP, V6, P161, DOI 10.1080/02674649166780231
   BIKLEN D, 1990, HARVARD EDUC REV, V60, P291
   Blakeslee S., 2002, NY TIMES
   Boyton J, 2012, EVIDENCED BASED COMM, V6, P3
   Chen GQG, 2012, ACTA MATH SCI, V32, P1
   Ericsdottir MD, 2009, MOTHERS COURAGE TALK
   Ferraioli SJ, 2011, BEHAV INTERVENT, V26, P261, DOI 10.1002/bin.336
   Finn P, 2005, AM J SPEECH-LANG PAT, V14, P172, DOI 10.1044/1058-0360(2005/018)
   HALO, 2012, LEARN RPM CAS STUD 2
   HALO, 2012, US SOM TIT
   HALO, 2012, ONL STOR
   HALO, 2012, LEARN RPM 1 1 RPM SE
   HALO: Helping Autism through Learning and Outreach, 2012, LEARN RPM FREQ QUEST
   Jacobson JW, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P363
   JACOBSON JW, 1995, AM PSYCHOL, V50, P750, DOI 10.1037//0003-066X.50.9.750
   Kodak T, 2011, HDB APPL BEHAV ANAL, P402
   Kohn D., 2009, CBSNEWS         1104
   Leekam SR, 1998, J CHILD PSYCHOL PSYC, V39, P951, DOI 10.1017/S0021963098003035
   McEdwards C., 2008, AUTISTIC POET GIVES
   Mukerjee M, 2004, SCI AM, V290, P49
   Mukhopadhyay S, 2008, UNDERSTANDING AUTISM, P84
   Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
   National Research Council, 2001, ED CHILDR AUT
   SIEGEL B, 1995, J AUTISM DEV DISORD, V25, P319, DOI 10.1007/BF02179293
   Van Acker R., 2006, FOCUS EXCEPTIONAL CH, V38, P8
   White PJ, 2011, RES AUTISM SPECT DIS, V5, P1283, DOI 10.1016/j.rasd.2011.02.003
   Wombles K., 2011, THINKING PERSONS GUI
   Wong C, 2012, J AUTISM DEV DISORD, V42, P2152, DOI 10.1007/s10803-012-1467-2
NR 28
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD AUG
PY 2014
VL 17
IS 4
BP 219
EP 223
DI 10.3109/17518423.2012.749952
PG 5
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA AJ8JK
UT WOS:000337949100001
PM 24102487
ER

PT J
AU Marschik, PB
   Vollmann, R
   Bartl-Pokorny, KD
   Green, VA
   van der Meer, L
   Wolin, T
   Einspieler, C
AF Marschik, Peter B.
   Vollmann, Ralf
   Bartl-Pokorny, Katrin D.
   Green, Vanessa A.
   van der Meer, Larah
   Wolin, Thomas
   Einspieler, Christa
TI Developmental profile of speech-language and communicative functions in
   an individual with the Preserved Speech Variant of Rett syndrome
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Communication; language; preserved speech variant; Rett syndrome; speech
ID VIDEO ANALYSIS; HOME VIDEO; AUTISM; DISORDER; CHILDREN; INFANTS; GIRLS;
   DIAGNOSIS; MECP2; AGE
AB Objective: We assessed various aspects of speech-language and communicative functions of an individual with the preserved speech variant of Rett syndrome (RTT) to describe her developmental profile over a period of 11 years.
   Methods: For this study, we incorporated the following data resources and methods to assess speech-language and communicative functions during pre-, peri-and post-regressional development: retrospective video analyses, medical history data, parental checklists and diaries, standardized tests on vocabulary and grammar, spontaneous speech samples and picture stories to elicit narrative competences.
   Results: Despite achieving speech-language milestones, atypical behaviours were present at all times. We observed a unique developmental speech-language trajectory (including the RTT typical regression) affecting all linguistic and socio-communicative sub-domains in the receptive as well as the expressive modality.
   Conclusion: Future research should take into consideration a potentially considerable discordance between formal and functional language use by interpreting communicative acts on a more cautionary note.
C1 [Marschik, Peter B.; Bartl-Pokorny, Katrin D.; Wolin, Thomas; Einspieler, Christa] Med Univ Graz, Inst Physiol IN Spired Dev Physiol & Dev Neurosci, Ctr Physiol Med, A-8010 Graz, Austria.
   [Vollmann, Ralf] Karl Franzens Univ Graz, Dept Linguist, Graz, Austria.
   [Green, Vanessa A.; van der Meer, Larah] Victoria Univ Wellington, Dept Educ Psychol, Wellington, New Zealand.
RP Marschik, PB (reprint author), Med Univ Graz, Inst Physiol IN Spired Dev Physiol & Dev Neurosci, Ctr Physiol Med, Harrachgasse 21-5, A-8010 Graz, Austria.
EM peter.marschik@medunigraz.at
FU Austrian Science Fund [FWF - P25241]; Lanyar Foundation [P337]
FX This study was supported by the Austrian Science Fund (FWF - P25241) and
   the Lanyar Foundation (P337).
CR Amir RE, 1999, NAT GENET, V23, P185
   Baranek GT, 2005, J AUTISM DEV DISORD, V35, P645, DOI 10.1007/s10803-005-008-7
   Bartl K, 2011, GRAZER LINGUISTISCHE, V75, P25
   Berman R. A., 1994, RELATING EVENTS NARR
   Bird EKR, 2008, J SPEECH LANG HEAR R, V51, P436, DOI 10.1044/1092-4388(2008/032)
   Botting N, 2002, CHILD LANG TEACH THE, V18, P1, DOI 10.1191/0265659002ct224oa
   Budden S, 2012, DEV MED CHILD NEUROL, V54, P339
   Burford B, 2005, BRAIN DEV-JPN, V27, pS3, DOI 10.1016/j.braindev.2005.03.013
   Carter P, 2010, MOVEMENT DISORD, V25, P282, DOI 10.1002/mds.22851
   Cass H, 2003, DEV MED CHILD NEUROL, V45, P325, DOI 10.1017/S0012162203000616
   Charman T, 2002, BRAIN DEV-JPN, V24, P281, DOI 10.1016/S0387-7604(02)00058-X
   Didden R, 2010, J DEV PHYS DISABIL, V22, P105, DOI 10.1007/s10882-009-9168-2
   Einspieler C, 2005, PEDIATR RES, V57, P696, DOI 10.1203/01.PDR.0000155945.94249.0A
   Einspieler C, 2005, BRAIN DEV, V27, P8, DOI DOI 10.1016/J.BRAINDEV.2005.03.014
   Einspieler C, 2012, DEV NEUROREHABIL, V15, P313, DOI 10.3109/17518423.2011.654281
   Einspieler C, 2008, J PSYCHOL, V216, P148
   Einspieler C, 1998, EARLY HUM DEV, V18, P101
   Fox A. V., 2006, TROG D TEST UBERPRUF
   Grimm H., 2001, SETK 3 5 SPRACHENTWI
   HAGBERG B, 1983, ANN NEUROL, V14, P471, DOI 10.1002/ana.410140412
   Hepflinger S, 2011, GRAZER LINGUISTISCHE, V75, P89
   Kaufmann WE, 2012, J INTELL DISABIL RES, V56, P233, DOI 10.1111/j.1365-2788.2011.01404.x
   Kauschke C, 2009, PDSS PATHOLINGUISTIS
   KERR AM, 1995, NEUROPEDIATRICS, V26, P67, DOI 10.1055/s-2007-979725
   Kerr AM, 2006, J INTELL DISABIL RES, V50, P386, DOI 10.1111/j.1365-2788.2005.00786.x
   Kiese-Himmel C., 2005, AWST R AKTIVER WORTS
   Laurvick CL, 2006, J PEDIATR-US, V148, P347, DOI 10.1016/j.jepds.2005.10.037
   Leinonen E, 2000, CHILDRENS PRAGMATIC
   Leonard H, 1998, DEV MED CHILD NEUROL, V40, P115
   Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094
   Marschik PB, 2011, KLIN NEUROPHYSIOL, V42, P22, DOI 10.1055/s-0030-1254118
   Marschik PB, 2007, EARLY HUM DEV, V83, P107, DOI 10.1016/j.earlhumdev.2006.05.009
   Marschik PB, 2012, RES DEV DISABIL, V33, P1715, DOI 10.1016/j.ridd.2012.05.014
   Marschik PB, 2012, RES DEV DISABIL, V33, P1749, DOI 10.1016/j.ridd.2012.04.012
   Marschik PB, 2012, RES DEV DISABIL, V33, P461, DOI 10.1016/j.ridd.2011.10.007
   Marschik PB, 2012, DEV MED CHILD NEUROL, V54, P451, DOI 10.1111/j.1469-8749.2012.04123.x
   Marschik PB, 2011, DEV NEUROREHABIL, V14, P355, DOI 10.3109/17518423.2011.604355
   Marschik PB, 2010, DEV MED CHILD NEUROL, V52, P218, DOI 10.1111/j.1469-8749.2009.03531.x
   Marschik PB, 2013, RES DEV DISABIL, V34, P1236, DOI 10.1016/j.ridd.2013.01.014
   Marschik PB, 2009, J AUTISM DEV DISORD, V39, P958, DOI 10.1007/s10803-009-0703-x
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P601, DOI 10.1016/j.rasd.2007.12.001
   Neul JL, 2010, ANN NEUROL, V68, P944, DOI 10.1002/ana.22124
   Neul Jeffrey Lorenz, 2012, Dialogues Clin Neurosci, V14, P253
   Ninio A., 1996, PRAGMATIC DEV
   Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
   Ozonoff S, 2011, J AM ACAD CHILD PSY, V50, P796, DOI 10.1016/j.jaac.2011.03.012
   Palomo R, 2006, J DEV BEHAV PEDIATR, V27, pS59, DOI 10.1097/00004703-200604002-00003
   Renieri A, 2009, BRAIN DEV-JPN, V31, P208, DOI 10.1016/j.braindev.2008.04.007
   Sigafoos J., 2006, ENHANCING EVERYDAY C
   Sigafoos J, 2011, RES AUTISM SPECT DIS, V5, P692, DOI 10.1016/j.rasd.2010.10.006
   Sigafoos J, 2000, COMMUNICATION DISORD, V21, P77, DOI 10.1177/152574010002100202
   Tams-Little S, 1998, BRAIN DEV, V18, P376
   Watson LR, 2013, AM J SPEECH-LANG PAT, V22, P25, DOI 10.1044/1058-0360(2012/11-0145)
   Zappella M, 1998, J AUTISM DEV DISORD, V28, P519, DOI 10.1023/A:1026052128305
NR 54
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD AUG
PY 2014
VL 17
IS 4
BP 284
EP 290
DI 10.3109/17518423.2013.783139
PG 7
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA AJ8JK
UT WOS:000337949100009
PM 23870013
ER

PT J
AU Langmaid, RA
   Papadopoulos, N
   Johnson, BP
   Phillips, JG
   Rinehart, NJ
AF Langmaid, Rebecca A.
   Papadopoulos, Nicole
   Johnson, Beth P.
   Phillips, James G.
   Rinehart, Nicole J.
TI Handwriting in Children With ADHD
SO JOURNAL OF ATTENTION DISORDERS
LA English
DT Article
DE ADHD; fine motor control
ID DEFICIT-HYPERACTIVITY DISORDER; MOTOR COORDINATION; ATTENTION;
   METHYLPHENIDATE; PERFORMANCE; MECHANISMS; DISEASE; FINE
AB Objective: Children with ADHD-combined type (ADHD-CT) display fine and gross motor problems, often expressed as handwriting difficulties. This study aimed to kinematically characterize the handwriting of children with ADHD using a cursive letter l's task. Method: In all, 28 boys (7-12 years), 14 ADHD-CT and 14 typically developing (TD), without developmental coordination disorder (DCD) or comorbid autism, wrote a series of four cursive letter l's using a graphics tablet and stylus. Results: Children with ADHD-CT had more inconsistent writing size than did TD controls. In addition, ADHD-CT symptom severity, specifically inattention, predicted poorer handwriting outcomes. Conclusion: In a sample of children with ADHD-CT who do not have DCD or autism, subtle handwriting differences were evident. It was concluded that handwriting might be impaired in children with ADHD in a manner dependent on symptom severity. This may reflect reports of underlying motor impairment in ADHD.
C1 [Langmaid, Rebecca A.; Papadopoulos, Nicole; Johnson, Beth P.; Phillips, James G.; Rinehart, Nicole J.] Monash Univ, Clayton, Vic 3800, Australia.
RP Rinehart, NJ (reprint author), Ctr Dev Psychiat & Psychol, 270 Ferntree Gully Rd, Notting Hill, Vic, Australia.
EM nicole.rinehart@monash.edu
FU National Health and Medical Research Council (NHMRC); Monash University
   [436609, APP1004387]
FX The author(s) disclosed receipt of the following financial support for
   the research and/or authorship of this article: The funding for this
   research was provided in part by the National Health and Medical
   Research Council (NHMRC) and Monash University [Project Grant 436609;
   Project Grant APP1004387].
CR Adi-Japha E, 2007, CORTEX, V43, P700, DOI 10.1016/S0010-9452(08)70499-4
   Altman D, 1991, PRACTICAL STAT MED R
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Berquin PC, 1998, NEUROLOGY, V50, P1087
   Bledsoe J, 2009, BIOL PSYCHIAT, V65, P620, DOI 10.1016/j.biopsych.2008.11.030
   Brossard-Racine M, 2011, DEV NEUROREHABIL, V14, P101, DOI 10.3109/17518423.2010.547545
   Caligiuri MP, 2010, PSYCHIAT RES, V177, P77, DOI 10.1016/j.psychres.2009.07.005
   Conners CK, 2001, CONNERS RATING SCALE
   Constantino J. N., 2007, SOCIAL RESPONSIVENES, V2
   Einfeld S. L., 2002, MANUAL DEV MENTAL BE
   Flapper BCT, 2006, DEV MED CHILD NEUROL, V48, P165, DOI 10.1017/S0012162206000375
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Frings M, 2010, CEREBELLUM, V9, P429, DOI 10.1007/s12311-010-0180-y
   Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
   Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
   HORE J, 1991, J NEUROPHYSIOL, V65, P563
   Langleben DD, 2006, PSYCHIAT RES, V141, P315, DOI 10.1016/j.psychres.2005.09.007
   Leitner Y, 2007, J NEUROL, V254, P1330, DOI 10.1007/s00415-006-0522-3
   PHILLIPS JG, 1994, MOVEMENT DISORD, V9, P521, DOI 10.1002/mds.870090504
   Phillips JG, 2009, HUM MOVEMENT SCI, V28, P619, DOI 10.1016/j.humov.2009.01.006
   PHILLIPS JG, 1991, HUM MOVEMENT SCI, V10, P301, DOI 10.1016/0167-9457(91)90009-M
   Piek JP, 1999, DEV MED CHILD NEUROL, V41, P159, DOI 10.1017/S0012162299000341
   Pitcher TM, 2003, DEV MED CHILD NEUROL, V45, P525
   Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
   PsychCorp, 1999, WASI MAN
   Racine MB, 2008, J CHILD NEUROL, V23, P399, DOI 10.1177/0883073807309244
   Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
   Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
   Rosenblum Sara, 2008, Phys Occup Ther Pediatr, V28, P219, DOI 10.1080/01942630802224934
   Teicher MH, 2000, NAT MED, V6, P470, DOI 10.1038/74737
   Tucha O, 2004, MOTOR CONTROL, V8, P461
   Van Gemmert AWA, 1999, NEUROPSYCHOLOGIA, V37, P685
   Wechsler D., 2003, WISC 4 AUSTR ADM SCO
   Williams P. E., 2003, 2 WISC4 PSYCH CORP
NR 35
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0547
EI 1557-1246
J9 J ATTEN DISORD
JI J. Atten. Disord.
PD AUG
PY 2014
VL 18
IS 6
BP 504
EP 510
DI 10.1177/1087054711434154
PG 7
WC Psychology, Developmental; Psychiatry
SC Psychology; Psychiatry
GA AJ9HF
UT WOS:000338018200003
PM 22617862
ER

PT J
AU Novotny, MA
   Sharp, KJ
   Rapp, JT
   Jelinski, JD
   Lood, EA
   Steffes, AK
   Ma, M
AF Novotny, Marissa A.
   Sharp, Katheryne J.
   Rapp, John T.
   Jelinski, Joel D.
   Lood, Elizabeth A.
   Steffes, Ayriel K.
   Ma, Monica
TI False positives with visual analysis for nonconcurrent multiple baseline
   designs and ABAB designs: Preliminary findings
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE AB designs; ABAB designs; False positives; Nonconcurrent multiple
   baseline designs; Reversal designs; Single-subject designs
ID YOUNG-CHILDREN; INTERVENTIONS; ACQUISITION; TECHNOLOGY; CONCURRENT;
   AUTISM; ADULTS; SKILLS
AB This study evaluated the probability of generating false positives with three-tier nonconcurrent multiple baseline (NMBL) designs and ABAB designs. For Experiment 1, we generated four sets of three-tier NMBL design graphs. The first, second, and third sets consisted of fixed A-phase data points for all three tiers at 0%, 25% and 50%, respectively, and randomly generated data points in the B phases. The fourth set consisted of randomly generated data points in the A and B phases for all three tiers. Across all four sets (N=1000), results show that false positives were produced with 7.5% of three-tier NMBL design graphs and were most probable when baseline levels were set at 0% or 25%. For Experiment 2, we generated 3000 ABAB design graphs consisting of three to five data points per phase. Results indicate that no false positives were produced, regardless of the number of data points included in each phase. Results of this study support specific guidelines for the use of NMBL designs and ABAB designs. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Novotny, Marissa A.; Sharp, Katheryne J.; Jelinski, Joel D.; Lood, Elizabeth A.; Steffes, Ayriel K.] St Cloud State Univ, St Cloud, MN 56301 USA.
   [Rapp, John T.] Auburn Univ, Auburn, AL 36849 USA.
   [Ma, Monica] Calif State Univ Sacramento, Sacramento, CA 95819 USA.
RP Rapp, JT (reprint author), Auburn Univ, Dept Psychol, 226 Thach, Auburn, AL 36849 USA.
EM jtr0014@auburn.edu
CR BAER DM, 1968, J APPL BEHAV ANAL, V1, P91, DOI 10.1901/jaba.1968.1-91
   Bauer SM, 2014, BEHAV INTERVENT, V29, P36, DOI 10.1002/bin.1368
   Carr JE, 2005, BEHAV INTERVENT, V20, P219, DOI 10.1002/bin.191
   Dallery J, 2013, J MED INTERNET RES, V15, DOI 10.2196/jmir.2227
   Chambless DL, 2001, ANNU REV PSYCHOL, V52, P685, DOI 10.1146/annurev.psych.52.1.685
   Christ TJ, 2007, PSYCHOL SCHOOLS, V44, P451, DOI 10.1002/pits.20237
   Cooper J. O., 2007, APPL BEHAV ANAL
   Detweiler D. D., 2005, FOCUS AUTISM OTHER D, V20, P98, DOI DOI 10.1177/10883576050200020601
   Donaldson JM, 2011, J APPL BEHAV ANAL, V44, P605, DOI 10.1901/jaba.2011.44-605
   Eikeseth S, 2003, J APPL BEHAV ANAL, V36, P325, DOI 10.1901/jaba.2003.36-325
   FRANCE KG, 1990, J APPL BEHAV ANAL, V23, P91, DOI 10.1901/jaba.1990.23-91
   Hawkins NG, 2007, AM J PREV MED, V33, P162, DOI 10.1016/j.amepre.2007.03.020
   Horner RH, 2012, EDUC TREAT CHILD, V35, P269
   Jerome J, 2007, J APPL BEHAV ANAL, V40, P185, DOI 10.1901/jaba.2007.41-06
   Johnston JM, 2009, STRATEGIES AND TACTICS OF BEHAVIORAL RESEARCH, THIRD EDITION, P1
   Kahng S, 2010, J APPL BEHAV ANAL, V43, P35, DOI 10.1901/jaba.2010.43-35
   Kazdin A. E., 2011, SINGLE CASE RES DESI
   Kratochwill T. R., 2010, SINGLE CASE DESIGNS
   Krueger TK, 2013, BEHAV MODIF, V37, P615, DOI 10.1177/0145445512468754
   Lequia J., 2014, BEHAV INTERVENT, V28, P322
   Lerman DC, 2004, J APPL BEHAV ANAL, V37, P11, DOI 10.1901/jaba.2004.37-11
   Levin JR, 2012, J SCHOOL PSYCHOL, V50, P599, DOI 10.1016/j.jsp.2012.05.001
   Matson M. L., 2012, RES AUTISM SPECT DIS, V6, P981
   May M. E., 2004, J BEHAV ED, V13, P267, DOI 10.1023/B:JOBE.0000044735.51022.5d
   Miltenberger R. G., 2012, BEHAV MODIFICATION P
   Parker RI, 2007, BEHAV THER, V38, P95, DOI 10.1016/j.beth.2006.05.002
   Rapp JT, 2012, BEHAV INTERVENT, V27, P16, DOI 10.1002/bin.342
   Reis MH, 2013, BEHAV INTERVENT, V28, P344, DOI 10.1002/bin.1371
   Richling SM, 2011, J APPL BEHAV ANAL, V44, P375, DOI 10.1901/jaba.2011.44-375
   Shadish WR, 2011, BEHAV RES METHODS, V43, P971, DOI 10.3758/s13428-011-0111-y
   Spencer TD, 2012, FOCUS AUTISM DEV DIS, V27, P225, DOI 10.1177/1088357612460274
   Tarbox J, 2009, J APPL BEHAV ANAL, V42, P901, DOI 10.1901/jaba.2009.42-901
   Twohig MP, 2001, J APPL BEHAV ANAL, V34, P217, DOI 10.1901/jaba.2001.34-217
   Twohig MP, 2007, J APPL BEHAV ANAL, V40, P619, DOI 10.1901/jaba.2007.619-632
   WATSON PJ, 1981, J BEHAV THER EXP PSY, V12, P257, DOI 10.1016/0005-7916(81)90055-0
NR 35
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD AUG
PY 2014
VL 8
IS 8
BP 933
EP 943
DI 10.1016/j.rasd.2014.04.009
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AJ8UF
UT WOS:000337982600001
ER

PT J
AU Matsuda, S
   Yamamoto, J
AF Matsuda, Soichiro
   Yamamoto, Junichi
TI Computer-based intervention for inferring facial expressions from the
   socio-emotional context in two children with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Facial expressions; Autism; Matching-to-sample; Socio-emotional
   situations; Emotion recognition
ID PERVASIVE DEVELOPMENTAL DISORDERS; CONDITIONAL DISCRIMINATION;
   DIAGNOSTIC INTERVIEW; ASPERGERS-SYNDROME; AFFECTIVE PROSODY; BASIC
   EMOTIONS; YOUNG-CHILDREN; RECOGNITION; PEOPLE; FACES
AB Difficulties in understanding others' emotions have been widely reported in autism spectrum disorders (ASDs). Many methodologies for evaluating the emotion recognition can be analyzed by matching-to-sample (MTS) procedures. When using movies of socio-emotional situations as sample stimuli, children with ASD have been found to have difficulties in understanding them. Furthermore, there are few intervention studies that have targeted understanding of socio-emotional situations in children with ASD. The present study examined whether two young children with ASD can acquire the relationships between movies of socio-emotional situations and pictures of facial expressions through computer-based MTS training. The movies of situations and pictures of facial expressions represented happy, surprised, angry and sad emotions. The child with ASD was required to select the picture of facial expression when presented with the movie of socio-emotional situations as a sample stimulus, and if so, whether these skills can be generalized to untrained stimuli. We used a multiple baseline design across participants, and the results demonstrated that both children learned the relationships and improved their performance with untrained stimuli. These findings are discussed in terms of procedures to increase the understanding of others' emotions at an early developmental stage. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Matsuda, Soichiro; Yamamoto, Junichi] Keio Univ, Dept Psychol, Tokyo, Japan.
RP Matsuda, S (reprint author), Keio Univ, Dept Psychol, Minato Ku, 2-15-45 Mita, Tokyo, Japan.
EM atom.opens.the.stargate@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Balconi M, 2007, RES DEV DISABIL, V28, P409, DOI 10.1016/j.ridd.2006.05.001
   Barlow D., 2009, SINGLE CASE EXPT DES
   Barrett K. C., 1987, HDB INFANT DEV, P555
   BARRETT KC, 1993, J NONVERBAL BEHAV, V17, P145, DOI 10.1007/BF00986117
   Buitelaar JK, 1999, DEV PSYCHOPATHOL, V11, P39, DOI 10.1017/S0954579499001947
   CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
   Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
   Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
   DAVIES S, 1994, J CHILD PSYCHOL PSYC, V35, P1033, DOI 10.1111/j.1469-7610.1994.tb01808.x
   Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0
   DUBE WV, 1993, J EXP ANAL BEHAV, V59, P103, DOI 10.1901/jeab.1993.59-103
   EKMAN P, 1992, COGNITION EMOTION, V6, P169, DOI 10.1080/02699939208411068
   EKMAN P, 1987, J PERS SOC PSYCHOL, V53, P712, DOI 10.1037/0022-3514.53.4.712
   FEIN D, 1992, J CHILD PSYCHOL PSYC, V33, P1157, DOI 10.1111/j.1469-7610.1992.tb00935.x
   Golan Ofer, 2010, J Autism Dev Disord, V40, P269, DOI 10.1007/s10803-009-0862-9
   Golan O, 2008, J AUTISM DEV DISORD, V38, P1534, DOI 10.1007/s10803-007-0533-7
   Gross TF, 2008, J AUTISM DEV DISORD, V38, P297, DOI 10.1007/s10803-007-0391-3
   Gross TF, 2004, J ABNORM CHILD PSYCH, V32, P469, DOI 10.1023/B:JACP.0000037777.17698.01
   Grossman RB, 2010, J SPEECH LANG HEAR R, V53, P778, DOI 10.1044/1092-4388(2009/08-0127)
   HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
   Ikuzawa M., 2002, KYOTO SCALE PSYCHOL
   Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MACDONALD H, 1989, J CHILD PSYCHOL PSYC, V30, P865, DOI 10.1111/j.1469-7610.1989.tb00288.x
   MAGUIRE RW, 1994, J AUTISM DEV DISORD, V24, P753, DOI 10.1007/BF02172284
   Matsuda S, 2013, RES AUTISM SPECT DIS, V7, P938, DOI 10.1016/j.rasd.2013.04.001
   PRIOR M, 1990, J CHILD PSYCHOL PSYC, V31, P587, DOI 10.1111/j.1469-7610.1990.tb00799.x
   Rosset DB, 2008, J AUTISM DEV DISORD, V38, P919, DOI 10.1007/s10803-007-0465-2
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   SIDMAN M, 1982, J EXP ANAL BEHAV, V37, P5, DOI 10.1901/jeab.1982.37-5
   Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
   Ueno K., 1991, PICTURE VOCABULARY T
   Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
   Wallace S, 2008, COGNITION EMOTION, V22, P1353, DOI 10.1080/02699930701782153
   Wilkinson KM, 1997, J EXP CHILD PSYCHOL, V67, P115, DOI 10.1006/jecp.1997.2402
NR 39
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD AUG
PY 2014
VL 8
IS 8
BP 944
EP 950
DI 10.1016/j.rasd.2014.04.010
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AJ8UF
UT WOS:000337982600002
ER

PT J
AU Goldin, RL
   Matson, JL
   Konst, MJ
   Adams, HL
AF Goldin, Rachel L.
   Matson, Johnny L.
   Konst, Matthew J.
   Adams, Hilary L.
TI A comparison of children and adolescents with ASD, atypical development,
   and typical development on the Behavioral Assessment System for
   Children, Second Edition (BASC-2)
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Atypical development; BASC-2
ID AUTISM-SPECTRUM DISORDERS; PSYCHIATRIC-DISORDERS; INTELLECTUAL
   DISABILITIES; CHALLENGING BEHAVIORS; FEEDING PROBLEMS; TRAITS BISCUIT;
   INFANT SCREEN; PREVALENCE; PSYCHOPATHOLOGY; SYMPTOMS
AB The present study examined the use of the Behavioral Assessment System for Children, Second Edition (BASC-2) in discerning 151 children and adolescents 12-16 years of age with autism spectrum disorder (ASD) from atypically and typically developing children and adolescents. Scores on the BASC-2 composites (i.e., externalizing behaviors, internalizing behaviors, behavior symptom index [BSI], adaptive behaviors) and subscales (i.e., hyperactivity, aggression, conduct problems, anxiety, depression, somatization, atypicality, withdrawal, attention, adaptability, social skills, leadership, activities of daily living, functional communication) were compared between children and adolescents with ASD, atypical development, and typical development. With the exception of aggression, somatization, and internalizing behaviors, participants with ASD were significantly more impaired than typically developing participants in all other composites and subscales. In comparison to atypically developing participants, the scores of participants with ASD evinced more impairment for BSI and its subscales, with the exception of attention, and the adaptive behavior composite and its subscales, with the exception of adaptability. Scores on the externalizing behaviors and internalizing behaviors composites and their subscales, with the exception of anxiety, were not significantly different. Research and clinical implications are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Goldin, Rachel L.; Matson, Johnny L.; Konst, Matthew J.; Adams, Hilary L.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Goldin, RL (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM rgoldi3@lsu.edu
CR American Academy of Child & Adolescent Psychiatry, 1999, J AM ACAD CHILD ADOL, V38, P325
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   BORTHWICKDUFFY SA, 1990, AM J MENT RETARD, V94, P586
   BREGMAN JD, 1991, J AM ACAD CHILD PSY, V30, P861, DOI 10.1097/00004583-199111000-00001
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Campbell J. M., 2006, PSYCHODIAGNOSTIC ASS
   Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
   Davis TE, 2010, RES AUTISM SPECT DIS, V4, P305, DOI 10.1016/j.rasd.2009.10.002
   Fodstad JC, 2009, DEV NEUROREHABIL, V12, P152, DOI 10.1080/17518420902936748
   Fodstad JC, 2010, J DEV PHYS DISABIL, V22, P381, DOI 10.1007/s10882-010-9202-4
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
   Gillberg C, 1996, DEV MED CHILD NEUROL, V38, P191
   Hattier MA, 2011, RES DEV DISABIL, V32, P2346, DOI 10.1016/j.ridd.2011.07.028
   Jarbrink K, 2003, J AUTISM DEV DISORD, V33, P395, DOI 10.1023/A:1025058711465
   Konst MJ, 2014, RES AUTISM SPECT DIS, V8, P147, DOI 10.1016/j.rasd.2013.10.011
   Konst MJ, 2014, RES AUTISM SPECT DIS, V8, P200, DOI 10.1016/j.rasd.2013.11.009
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Locke J. M., 2008, CLIN ASSESSMENT INTE, P265
   Macken J., 2009, J MENTAL HLTH RES IN, V2, P29
   MacNeil BM, 2009, RES AUTISM SPECT DIS, V3, P1, DOI 10.1016/j.rasd.2008.06.001
   Mahan S, 2011, RES AUTISM SPECT DIS, V5, P119, DOI 10.1016/j.rasd.2010.02.007
   Matson J. L, 2013, RES AUTISM SPECT DIS, V7, P1004
   Matson J. L., 2008, J INTELLECT DEV DIS, V33, P313
   Matson J. L., 2005, J EDUC PSYCHOL, V25, P151, DOI DOI 10.1080/0144341042000301148
   Matson J. L., 2009, RES DEV DISABIL, V30, P1288
   Matson JL, 2008, RES DEV DISABIL, V29, P341, DOI 10.1016/j.ridd.2007.06.006
   Matson JL, 2001, RES DEV DISABIL, V22, P165, DOI 10.1016/S0891-4222(01)00065-8
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   Matson JL, 2007, RES DEV DISABIL, V28, P567, DOI 10.1016/j.ridd.2006.08.001
   Matson JL, 2009, J DEV PHYS DISABIL, V21, P195, DOI 10.1007/s10882-009-9135-y
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P336, DOI 10.1016/j.rasd.2008.08.001
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Matson JL, 2009, RES DEV DISABIL, V30, P249, DOI 10.1016/j.ridd.2008.04.002
   Matson JL, 2013, RES AUTISM SPECT DIS, V7, P1318, DOI 10.1016/j.rasd.2013.07.018
   Matson JL, 2008, J DEV PHYS DISABIL, V20, P41, DOI 10.1007/s10882-007-9078-0
   Matson JL, 2008, BEHAV MODIF, V32, P61, DOI 10.1177/0145445507304581
   Matson JL, 2005, RES DEV DISABIL, V26, P399, DOI 10.1016/j.ridd.2004.11.008
   Nicholas JS, 2008, ANN EPIDEMIOL, V18, P130, DOI 10.1016/i.annepidem.2007.10.013
   Norwich B., 2005, SPECIAL TEACHING SPE
   Perry A, 2009, J AUTISM DEV DISORD, V39, P1066, DOI 10.1007/s10803-009-0704-9
   Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
   Rice C., 2009, MORBIDITY MORTALITY, V58
   Rutter M, 2000, J ABNORM CHILD PSYCH, V28, P3, DOI 10.1023/A:1005113900068
   RUTTER M, 1994, J CHILD PSYCHOL PSYC, V35, P311, DOI 10.1111/j.1469-7610.1994.tb01164.x
   Schreibman L., 2005, SCI FICTION AUTISM
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sipes M, 2011, DEV NEUROREHABIL, V14, P261, DOI 10.3109/17518423.2011.577050
   Smalley SL, 1997, AM J HUM GENET, V60, P1276, DOI 10.1086/515485
   Smith KRM, 2010, RES DEV DISABIL, V31, P743, DOI 10.1016/j.ridd.2010.01.016
   Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
   Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
   Stella J, 1999, J AUTISM DEV DISORD, V29, P307, DOI 10.1023/A:1022111419409
   Tureck K, 2014, J DEV PHYS DISABIL, V26, P23, DOI 10.1007/s10882-013-9342-4
   Volker MA, 2010, J AUTISM DEV DISORD, V40, P188, DOI 10.1007/s10803-009-0849-6
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Wing L, 1996, BRIT MED J, V312, P327
NR 59
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD AUG
PY 2014
VL 8
IS 8
BP 951
EP 957
DI 10.1016/j.rasd.2014.04.005
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AJ8UF
UT WOS:000337982600003
ER

PT J
AU Dolev, S
   Oppenheim, D
   Koren-Karie, N
   Yirmiya, N
AF Dolev, Smadar
   Oppenheim, David
   Koren-Karie, Nina
   Yirmiya, Nurit
TI Early attachment and maternal insightfulness predict educational
   placement of children with autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Educational placement; Maternal insightfulness; Attachment
ID SPECTRUM DISORDER; SEVERE DISABILITIES; YOUNG-CHILDREN; MOTHERS
   INSIGHTFULNESS; INTERNAL EXPERIENCE; PRESCHOOL-CHILDREN;
   MENTAL-RETARDATION; PARENTS; SENSITIVITY; INFANTS
AB We examined whether mothers' insightfulness - their capacity to "see things from the child's point of view" - and children's attachment, both assessed during the preschool years, are associated with the educational placement of children with ASD in middle childhood and early adolescence beyond the prediction offered by children's IQ and interactive competence. 39 boys with autism and their mothers participated. We assessed mothers' insightfulness, and children's attachment to their mothers, their intelligence and their interactional competencies. The results supported our hypothesis. The emotional quality of the relationship between the children and their mothers during the preschool age, as reflected in the mothers' insightfulness and the children's attachment security, predicted children's educational placement in inclusive programs 4.5 and 8.5 years later, over and above the prediction offered by children's IQ and their interactive competence. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Dolev, Smadar] Oranim Coll Educ, Early Childhood Dept, IL-36006 Tivon, Israel.
   [Oppenheim, David; Koren-Karie, Nina] Ctr Study Child Dev, IL-3498838 Haifa, Israel.
   [Yirmiya, Nurit] Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel.
RP Dolev, S (reprint author), Oranim Coll Educ, Early Childhood Dept, IL-36006 Tivon, Israel.
EM smadar_d@oranim.ac.il; oppenhei@psy.haifa.ac.il; nkoren@psy.haifa.ac.il;
   nyirmiya@gmail.com
CR Ainsworth M. S., 1978, PATTERNS ATTACHMENT
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
   Bayley N, 1993, BAYLEY SCALES INFANT
   Belsky Jay, 2002, Attach Hum Dev, V4, P361, DOI 10.1080/14616730210167267
   Ben-Simhon Mualem E, 2011, CORRELATION MAT SENS
   Biringen Z., 1998, EMOTIONAL AVAILABILI, V3rd
   Brim D, 2009, RES AUTISM SPECT DIS, V3, P942, DOI 10.1016/j.rasd.2009.04.004
   Capps L., 1997, CHILDREN AUTISM DEV
   CAPPS L, 1994, DEV PSYCHOPATHOL, V6, P249, DOI 10.1017/S0954579400004569
   Clifford S, 2009, J AUTISM DEV DISORD, V39, P1369, DOI 10.1007/s10803-009-0748-x
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Eldar E, 2010, INT J INCLUSIVE EDUC, V14, P97, DOI 10.1080/13603110802504150
   Frank A. R., 1998, ED TREATMENT CHILDRE, V21, P275
   Fryxell D, 1995, J ASSOC PERS SEVERE, V20, P259
   Gray KM, 2001, J PAEDIATR CHILD H, V37, P221, DOI 10.1046/j.1440-1754.2001.00653.x
   HARRIS SL, 1991, J AUTISM DEV DISORD, V21, P281, DOI 10.1007/BF02207325
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Harrower J. K., 1999, J POSIT BEHAV INTERV, V1, P215, DOI 10.1177/109830079900100404
   Hundert J, 1998, EARLY CHILD RES Q, V13, P49, DOI 10.1016/S0885-2006(99)80025-8
   HUNT P, 1994, J ASSOC PERS SEVERE, V19, P200
   Kaufman AS, 1983, KAUFMAN ASSESSMENT B
   Koren-Karie N., 2001, INSIGHTFULNESS PROCE
   Koren-Karie N, 2002, DEV PSYCHOL, V38, P534, DOI 10.1037/0012-1649.38.4.534
   Koren-Karie N, 2009, J CHILD PSYCHOL PSYC, V50, P643, DOI 10.1111/j.1469-7610.2008.02043.x
   Laws G, 2001, EDUC RES, V43, P209, DOI 10.1080/00131880110051173
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   Ministry of Education-Israel, 1988, SPEC ED LAW
   Oppenheim D, 2001, INT J BEHAV DEV, V25, P16
   Oppenheim D, 2012, ATTACH HUM DEV, V14, P567, DOI 10.1080/14616734.2012.727256
   Oppenheim D, 2002, INF MENTAL HLTH J, V23, P593, DOI 10.1002/imhj.10035
   Oppenheim D, 2009, CHILD DEV, V80, P519, DOI 10.1111/j.1467-8624.2009.01276.x
   PIERCE K, 1995, J APPL BEHAV ANAL, V28, P285, DOI 10.1901/jaba.1995.28-285
   Pipp-Siegel S, 1999, MONOGR SOC RES CHILD, V64, P25, DOI 10.1111/1540-5834.00032
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Rutgers AH, 2007, J ABNORM CHILD PSYCH, V35, P859, DOI 10.1007/s10802-007-9139-y
   Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
   Rydell AM, 2005, ATTACH HUM DEV, V7, P187, DOI 10.1080/14616730500134282
   RYNDAK DL, 1995, J ASSOC PERS SEVERE, V20, P147
   Schietecatte I, 2012, J AUTISM DEV DISORD, V42, P1, DOI 10.1007/s10803-011-1209-x
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   Solomon J, 1986, AFFECTIVE DEV INFANC, P95
   Solomon M, 2008, J AUTISM DEV DISORD, V38, P1767, DOI 10.1007/s10803-008-0567-5
   Sroufe LA, 2005, ATTACH HUM DEV, V7, P349, DOI 10.1080/14616730500365928
   Thompson R. A., 2008, HDB ATTACHMENT
   UNESCO-United Nations Educational Scientific and Cultural Organization, 1994, INCL ED
   VAN IJZENDOORN MH, 1988, CHILD DEV, V59, P147, DOI 10.2307/1130396
   van IJzendoorn MH, 2007, CHILD DEV, V78, P597, DOI 10.1111/j.1467-8624.2007.01016.x
   Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
   Williams E, 2003, AUTISM, V7, P361, DOI 10.1177/1362361303007004003
   Zeanah C., 2009, HDB INFANT MENTAL HL
NR 51
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD AUG
PY 2014
VL 8
IS 8
BP 958
EP 967
DI 10.1016/j.rasd.2014.04.012
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AJ8UF
UT WOS:000337982600004
ER

PT J
AU Matson, JL
   Jang, JN
AF Matson, Johnny L.
   Jang, Jina
TI Conceptualizing skills that are most critical in diagnosing autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Core symptoms; Autism; Differential diagnosis; DSM-5
ID PERVASIVE DEVELOPMENTAL DISORDER; DSM-IV-TR; INTENSIVE BEHAVIORAL
   INTERVENTION; SPECTRUM DISORDERS; INTELLECTUAL DISABILITY; CHALLENGING
   BEHAVIORS; ASPERGERS SYNDROME; FEEDING PROBLEMS; INFANT SCREEN; PDD-NOS
AB Autism spectrum disorders (ASD) consist of a broad but heterogeneous group of symptoms. This factor has resulted in a debate as to whether the disorder is a unitary construct or a group of related disorders with a similar symptom presentation. Additionally, some core symptoms are seen in other developmental disabilities such as intellectual disability. This review covers these and related issues in the context of what symptoms are most critical for diagnosing ASD and distinguishing it from other developmental disabilities. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Matson, Johnny L.; Jang, Jina] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Jang, JN (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM Jinajang87@gmail.com
CR Alexander JL, 2013, RES AUTISM SPECT DIS, V7, P1346, DOI 10.1016/j.rasd.2013.07.021
   Allen G, 2004, BIOL PSYCHIAT, V56, P269, DOI 10.1016/j.biophsych.2004.06.005
   Allen G, 2006, CLIN NEUROSCI RES, V6, P195, DOI 10.1016/j.cnr.2006.06.002
   Beighley JS, 2014, RES AUTISM SPECT DIS, V8, P74, DOI 10.1016/j.rasd.2013.10.014
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Duchan E, 2012, PEDIATR CLIN N AM, V59, P27, DOI 10.1016/j.pcl.2011.10.003
   Fodstad JC, 2009, DEV NEUROREHABIL, V12, P152, DOI 10.1080/17518420902936748
   Foss-Feig JH, 2012, RES AUTISM SPECT DIS, V6, P337, DOI 10.1016/j.rasd.2011.06.007
   Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
   Gillberg C., 2013, SCI WORLD J, V2013, P716
   Lauvin M-A, 2012, Diagn Interv Imaging, V93, P139, DOI 10.1016/j.diii.2012.01.007
   Gould E, 2011, RES AUTISM SPECT DIS, V5, P990, DOI 10.1016/j.rasd.2011.01.012
   Han YMY, 2013, RES AUTISM SPECT DIS, V7, P662, DOI 10.1016/j.rasd.2013.02.011
   Horovitz M, 2010, DEV NEUROREHABIL, V13, P390, DOI 10.3109/17518423.2010.501431
   Jackson LS, 2013, RES AUTISM SPECT DIS, V7, P1160, DOI 10.1016/j.rasd.2013.06.005
   Jones EJH, 2014, NEUROSCI BIOBEHAV R, V39, P1, DOI 10.1016/j.neubiorev.2013.12.001
   Kaiser MD, 2012, DEV COGN NEUROS-NETH, V2, P25, DOI 10.1016/j.dcn.2011.05.005
   Kouijzer MEJ, 2009, RES AUTISM SPECT DIS, V3, P145, DOI 10.1016/j.rasd.2008.05.001
   Kozlowski AM, 2012, RES AUTISM SPECT DIS, V6, P472, DOI 10.1016/j.rasd.2011.07.007
   Kuhn DE, 2002, J INTELLECT DEV DIS, V27, P161, DOI 10.1080/1366825021000008594
   Kuppens S, 2012, RES AUTISM SPECT DIS, V6, P168, DOI 10.1016/j.rasd.2011.04.002
   Leonard H, 2010, RES AUTISM SPECT DIS, V4, P548, DOI 10.1016/j.rasd.2010.01.003
   Love JR, 2009, RES AUTISM SPECT DIS, V3, P421, DOI 10.1016/j.rasd.2008.08.008
   LoVullo SV, 2009, RES DEV DISABIL, V30, P1288, DOI 10.1016/j.ridd.2009.05.004
   LoVullo SV, 2012, RES AUTISM SPECT DIS, V6, P378, DOI 10.1016/j.rasd.2011.06.011
   Magiati I, 2014, CLIN PSYCHOL REV, V34, P73, DOI 10.1016/j.cpr.2013.11.002
   Matson J, 2008, J INTELLECT DEV DIS, V33, P323, DOI 10.1080/13668250802492600
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P533, DOI 10.1016/j.rasd.2007.11.001
   Matson J. L., 2005, ED PSYCHOL, V25, P151, DOI DOI 10.1080/0144341042000301148
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P288, DOI 10.1016/j.rasd.2007.07.003
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P237, DOI 10.1016/j.rasd.2007.06.003
   Matson JL, 2009, RES DEV DISABIL, V30, P1317, DOI 10.1016/j.ridd.2009.05.008
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   Matson JL, 2012, J AUTISM DEV DISORD, V42, P1549, DOI 10.1007/s10803-012-1582-0
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P400, DOI 10.1016/j.rasd.2009.10.010
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Matson JL, 2007, J INTELLECT DEV DIS, V32, P39, DOI 10.1080/13668250601184689
   Matson JL, 2012, J DEV PHYS DISABIL, V24, P403, DOI 10.1007/s10882-012-9278-0
   Matson JL, 1997, RES DEV DISABIL, V18, P471, DOI 10.1016/S0891-4222(97)00023-1
   Matson JL, 2009, RES DEV DISABIL, V30, P249, DOI 10.1016/j.ridd.2008.04.002
   Matson JL, 2010, DEV NEUROREHABIL, V13, P72, DOI 10.3109/17518420903213576
   Matson JL, 2009, RES DEV DISABIL, V30, P961, DOI 10.1016/j.ridd.2009.01.009
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P300, DOI 10.1016/j.rasd.2009.10.001
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P696, DOI 10.1016/j.rasd.2008.02.003
   Matson JL, 2012, RES AUTISM SPECT DIS, V6, P573, DOI 10.1016/j.rasd.2011.10.009
   Matson JL, 2005, RES DEV DISABIL, V26, P399, DOI 10.1016/j.ridd.2004.11.008
   Matson JL, 2009, RES DEV DISABIL, V30, P1203, DOI 10.1016/j.ridd.2009.04.001
   Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
   Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P298, DOI 10.1016/j.rasd.2012.08.011
   Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P277, DOI 10.1016/j.rasd.2011.05.009
   McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
   Nazeer A, 2012, PEDIATR CLIN N AM, V59, P19, DOI 10.1016/j.pcl.2011.10.007
   Acosta Maria T, 2004, Semin Pediatr Neurol, V11, P205, DOI 10.1016/j.spen.2004.07.004
   Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
   Piggot J, 2009, NEUROSCIENCE, V164, P247, DOI 10.1016/j.neuroscience.2009.05.054
   Rapin I, 2008, PEDIATR CLIN N AM, V55, P1129, DOI 10.1016/j.pcl.2008.07.005
   Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013
   Sanders J, 2008, RES AUTISM SPECT DIS, V2, P1, DOI 10.1016/j.rasd.2007.03.005
   Sappok T, 2014, RES AUTISM SPECT DIS, V8, P362, DOI 10.1016/j.rasd.2013.12.016
   Sevlever M, 2010, RES DEV DISABIL, V31, P976, DOI 10.1016/j.ridd.2010.04.014
   Smith KRM, 2010, RES DEV DISABIL, V31, P743, DOI 10.1016/j.ridd.2010.01.016
   Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
   Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
   Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014
   Vanvuchelen M, 2011, RES AUTISM SPECT DIS, V5, P89, DOI 10.1016/j.rasd.2010.07.010
   Waterhouse L., 2013, AUTISM SYMPTOMS EXIS
   Worley JA, 2012, RES AUTISM SPECT DIS, V6, P965, DOI 10.1016/j.rasd.2011.12.012
   Zachor DA, 2007, RES AUTISM SPECT DIS, V1, P304, DOI 10.1016/j.rasd.2006.12.001
NR 68
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD AUG
PY 2014
VL 8
IS 8
BP 968
EP 973
DI 10.1016/j.rasd.2014.04.011
PG 6
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AJ8UF
UT WOS:000337982600005
ER

PT J
AU Makinen, L
   Loukusa, S
   Leinonen, E
   Moilanen, I
   Ebeling, H
   Kunnari, S
AF Makinen, Leena
   Loukusa, Soile
   Leinonen, Eeva
   Moilanen, Irma
   Ebeling, Hanna
   Kunnari, Sari
TI Characteristics of narrative language in autism spectrum disorder:
   Evidence from the Finnish
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Comprehension; Linguistic structure;
   Narratives; Pragmatics; Referencing
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; COHERENCE ACCOUNT;
   NORMAL-CHILDREN; STORY RECALL; ABILITY; COMMUNICATION; IMPAIRMENT;
   SYMPTOMATOLOGY; COMPREHENSION
AB This study examined linguistic and pragmatic aspects of narrative abilities of children with autism spectrum disorder (ASD), which have not been studied thoroughly and not at all in Finnish. Sixteen five- to ten-year-old Finnish high-functioning children with ASD (mean age 7;7 years) and 16 age-matched typically developing children (mean age 7;5 years) participated in this study. Children's picture-based narrations were analyzed for narrative productivity, syntactic complexity, referential accuracy, event content, use of additional and extraneous information, mental state expressions, and narrative comprehension. Several linguistic- and pragmatic-based measures were used in order to gain a comprehensive picture of strengths and weaknesses that children with ASD might show in storytelling. The use of linguistic structure, referential accuracy and mental state expressions was similar between the groups. However, children with ASD showed difficulties in establishing informative story content, making inferences from story events and an ability not to include extraneous information into their stories. Therefore, the problems seen in their narrative language use can be described as being related to pragmatic aspects of narration. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Makinen, Leena; Loukusa, Soile; Kunnari, Sari] Univ Oulu, Fac Humanities Logoped, Oulu 90014, Finland.
   [Makinen, Leena; Loukusa, Soile; Kunnari, Sari] Univ Oulu, Child Language Res Ctr, Oulu 90014, Finland.
   [Leinonen, Eeva] Univ Wollongong, Sch Psychol, Wollongong, NSW 2522, Australia.
   [Moilanen, Irma; Ebeling, Hanna] Univ Hosp Oulu, Inst Clin Med, Dept Child Psychiat, Oulu 90029, Finland.
RP Makinen, L (reprint author), Univ Oulu, Fac Humanities Logoped, POB 1000, Oulu 90014, Finland.
EM leena.makinen@oulu.fi; soile.loukusa@oulu.fi; leinonen@uow.edu.au;
   irma.moilanen@oulu.fi; hanna.ebeling@oulu.fi; sari.kunnari@oulu.fi
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
   Arnold JE, 2009, COGNITION, V110, P131, DOI 10.1016/j.cognition.2008.10.016
   Astington J. W., 2005, THE DEVELOPMENT OF S, P205
   BALTAXE CAM, 1992, J AUTISM DEV DISORD, V22, P1, DOI 10.1007/BF01046399
   BAMBERG M, 1991, J CHILD LANG, V18, P689
   Barnes JL, 2009, AUTISM RES, V2, P148, DOI 10.1002/aur.79
   Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
   BARONCOHEN S, 1986, BRIT J DEV PSYCHOL, V4, P113
   Baron-Cohen S., 1995, MINDBLINDNESS AN ESS
   Boudreau D., 2007, LANGUAGE DISORDERS D, P331
   Chafe W., 1988, CLAUSE COMBINING GRA, P1
   Cohen J., 1988, STATISTICAL POWER AN
   Condouris K, 2003, AM J SPEECH-LANG PAT, V12, P349, DOI 10.1044/1058-0360(2003/080)
   Cummings L, 2009, CLINICAL PRAGMATICS, P1
   d Health Organization, 1993, INTERNATIONAL CLASSI
   Diehl JJ, 2006, J ABNORM CHILD PSYCH, V34, P87, DOI 10.1007/s10802-005-9003-x
   Eaton JH, 1999, J CHILD LANG, V26, P699, DOI 10.1017/S0305000999003967
   Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2
   Gabig CS, 2008, LANG SPEECH HEAR SER, V39, P498, DOI 10.1044/0161-1461(2008/07-0023)
   German D.J., 2000, TEST OF WORD FINDING
   Grice H. P., 1975, SYNTAX SEMANTICS, P41, DOI DOI 10.1017/S0022226700005296
   Hale CM, 2005, J AUTISM DEV DISORD, V35, P519, DOI 10.1007/s10803-005-5065-4
   Hale CM, 2005, AUTISM, V9, P157, DOI 10.1177/1362361305051395
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Hughes D., 1997, GUIDE TO NARRATIVE L
   Kirk S. A., 1968, ILLINOIS TEST OF PSY
   Korkman M., 2008, NEPSY II LASTEN NEUR
   Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
   Lord C., 1995, AUTISM DIAGNOSTIC IN
   Lord C., 2000, AUTISM DIAGNOSTIC OB
   Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
   Loucas T, 2008, J CHILD PSYCHOL PSYC, V49, P1184, DOI 10.1111/j.1469-7610.2008.01951.x
   Loukusa S, 2009, RES AUTISM SPECT DIS, V3, P890, DOI 10.1016/j.rasd.2009.05.002
   Loukusa S, 2007, J AUTISM DEV DISORD, V37, P1049, DOI 10.1007/s10803-006-0247-2
   Loukusa S, 2007, J COMMUN DISORD, V40, P357, DOI 10.1016/j.jcomdis.2006.10.001
   MacWhinney B. A., 2000, THE CHILDES PROJECT
   Makinen L, 2014, CLIN LINGUIST PHONET, V28, P413, DOI 10.3109/02699206.2013.875592
   Makinen L, 2014, FIRST LANG, V34, P24, DOI 10.1177/0142723713511000
   Mar RA, 2006, J RES PERS, V40, P694, DOI 10.1016/j.jrp.2005.08.002
   McGhee R., 2007, TOKEN TEST FOR CHILD
   Norbury C. F., 2013, JOURNAL OF CHILD LAN
   Norbury CF, 2002, INT J LANG COMM DIS, V37, P227, DOI 10.1080/13682820210136269
   Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
   Novogrodsky R, 2013, CLIN LINGUIST PHONET, V27, P85, DOI 10.3109/02699206.2012.742567
   Nuske HJ, 2011, INT J LANG COMM DIS, V46, P108, DOI 10.3109/13682822.2010.484847
   Rumpf AL, 2012, RES DEV DISABIL, V33, P1395, DOI 10.1016/j.ridd.2012.03.007
   Saalasti S, 2008, J AUTISM DEV DISORD, V38, P1574, DOI 10.1007/s10803-008-0540-3
   Tulviste T., 2004, ONGOING THEMES IN PS
   Volden J, 1999, J AUTISM DEV DISORD, V29, P203, DOI 10.1023/A:1023028021580
   Volden J, 2007, J AUTISM DEV DISORD, V37, P1139, DOI 10.1007/s10803-006-0256-1
   Wilcock G., 2006, SKY J LINGUISTICS, V19, P291
   Young EC, 2005, LANG SPEECH HEAR SER, V36, P62, DOI 10.1044/0161-1461(2005/006)
NR 53
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD AUG
PY 2014
VL 8
IS 8
BP 987
EP 996
DI 10.1016/j.rasd.2014.05.001
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA AJ8UF
UT WOS:000337982600007
ER

PT J
AU Tanaka, JW
   Quim, PC
   Xu, BY
   Maynard, K
   Huxtable, N
   Lee, K
   Pascalis, O
AF Tanaka, James W.
   Quim, Paul C.
   Xu, Buyun
   Maynard, Kim
   Huxtable, Natalie
   Lee, Kang
   Pascalis, Olivier
TI The effects of information type (features vs. configuration) and
   location (eyes vs. mouth) on the development of face perception
SO JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
LA English
DT Article
DE Face recognition; Face perception; Configural processing; Featural
   processing; Face strategies
ID AUTISM SPECTRUM DISORDER; FACIAL FEATURES; PROCESSING DEVELOPS; NEWBORNS
   PREFERENCE; SPATIAL RELATIONS; EARLY MATURITY; RECOGNITION; INVERSION;
   PROSOPAGNOSIA; SENSITIVITY
AB The goal of the current study was to investigate the development of face processing strategies in a perceptual discrimination task. Children (7-12 years of age) and young adults were administered the Face Dimensions Task. In the Face Dimensions Task, participants were asked to judge whether two simultaneously presented faces were the "same" or "different". For the "same" trials, the two faces were identical. For the "different" trials, the faces differed in either the spacing between the eyes, the spacing between the nose and the mouth, the size of the eyes, or the size of the mouth. The main finding was that 7- to 10-year-old children showed no difference in their ability to discriminate differences in eye size and eye spacing but showed a poor ability to discriminate differences in nose and mouth spacing and, to a lesser extent, mouth size. The developmental lag between nose-mouth discriminations and the other featural and configural discriminations was reduced in older children and eliminated by young adulthood. These results indicate that the type of face information (i.e., configural vs. featural) and its location (i.e., eye vs. mouth) jointly contribute to the development of face perception abilities. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Tanaka, James W.; Xu, Buyun; Maynard, Kim; Huxtable, Natalie] Univ Victoria, Dept Psychol, Victoria, BC V8W 3P5, Canada.
   [Quim, Paul C.] Univ Delaware, Dept Psychol, Newark, DE 19716 USA.
   [Lee, Kang] Univ Toronto, Eric Jackman Inst Child Study, Toronto, ON M5S 1V6, Canada.
   [Pascalis, Olivier] Univ Pierre Mendes France, Lab Psychol & Neurocognit, CNRS UMR 5105, F-38040 Grenoble, France.
RP Tanaka, JW (reprint author), Univ Victoria, Dept Psychol, POB 3050, Victoria, BC V8W 3P5, Canada.
EM jtanaka@uvic.ca
CR Bhatt RS, 2005, CHILD DEV, V76, P169, DOI 10.1111/j.1467-8624.2005.00837.x
   Bukach CM, 2008, J NEUROPSYCHOL, V2, P227, DOI 10.1348/174866407X231010
   Caldara R, 2005, J COGNITIVE NEUROSCI, V17, P1652, DOI 10.1162/089892905774597254
   Chien S. H. L., 2011, J VISION, V11, P1
   Cooper EE, 2000, J EXP PSYCHOL LEARN, V26, P470, DOI 10.1037//0278-7393.26.2.470
   Crookes K, 2012, J EXP PSYCHOL HUMAN, V38, P1428, DOI 10.1037/a0027943
   Crookes K, 2009, COGNITION, V111, P219, DOI 10.1016/j.cognition.2009.02.004
   DeGutis J, 2012, COGN NEUROPSYCHOL, V29, P419, DOI 10.1080/02643294.2012.754745
   Farkas LG, 2005, J CRANIOFAC SURG, V16, P615, DOI 10.1097/01.scs.0000171847.58031.9e
   Ge LZ, 2008, J EXP CHILD PSYCHOL, V101, P124, DOI 10.1016/j.jecp.2008.05.006
   Germine LT, 2011, COGNITION, V118, P201, DOI 10.1016/j.cognition.2010.11.002
   Gilchrist A, 2003, VIS COGN, V10, P769, DOI 10.1080/13506280344000022
   Goffaux V, 2007, J EXP PSYCHOL HUMAN, V33, P995, DOI 10.1037/0096-1523.33.4.995
   HAITH MM, 1977, SCIENCE, V198, P853, DOI 10.1126/science.918670
   Hay DC, 2000, INFANT CHILD DEV, V9, P199, DOI 10.1002/1522-7219(200012)9:4<199::AID-ICD231>3.3.CO;2-B
   JOHNSON MH, 1991, COGNITION, V40, P1, DOI 10.1016/0010-0277(91)90045-6
   Keen R, 2003, CURR DIR PSYCHOL SCI, V12, P79, DOI 10.1111/1467-8721.01234
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Lawrence K, 2008, J NEUROPSYCHOL, V2, P27, DOI 10.1348/174866407X231074
   Le Grand R, 2001, NATURE, V410, P890, DOI 10.1038/35073749
   Leo I, 2009, DEVELOPMENTAL SCI, V12, P492, DOI 10.1111/j.1467-7687.2008.00791.x
   Liu S, 2013, INFANT CHILD DEV, V22, P165, DOI 10.1002/icd.1781
   Malcolm GL, 2004, PERCEPTION, V33, P1221, DOI 10.1068/p5372
   McKone E, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00033
   McKone E, 2006, J EXP CHILD PSYCHOL, V94, P134, DOI 10.1016/j.jecp.2006.01.001
   Mondloch CJ, 2006, CHILD DEV, V77, P234, DOI 10.1111/j.1467-8624.2006.00867.x
   Mondloch CJ, 2004, J EXP CHILD PSYCHOL, V89, P159, DOI 10.1016/j.jecp.2004.07.002
   Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339
   Mondloch CJ, 2006, PSYCHOL SCI, V17, P930, DOI 10.1111/j.1467-9280.2006.01806.x
   Mondloch CJ, 2008, CHILD DEV, V79, P1513, DOI 10.1111/j.1467-8624.2008.01202.x
   Oakes LM, 2013, INFANCY, V18, P134, DOI 10.1111/j.1532-7078.2011.00107.x
   Pellicano E, 2006, DEVELOPMENTAL SCI, V9, P270, DOI 10.1111/j.1467-7687.2006.00489.x
   Piepers DW, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00559
   Quinn PC, 2013, VIS COGN, V21, P23, DOI 10.1080/13506285.2013.764370
   Quinn PC, 2009, INFANCY, V14, P474, DOI 10.1080/15250000902994248
   Rossion B, 2008, ACTA PSYCHOL, V128, P274, DOI 10.1016/j.actpsy.2008.02.003
   Rossion B, 2009, J NEUROPSYCHOL, V3, P69, DOI 10.1348/174866408X289944
   Rutherford MD, 2007, VISION RES, V47, P2099, DOI 10.1016/j.visres.2007.01.029
   Sekunova A, 2008, J EXP PSYCHOL HUMAN, V34, P1129, DOI 10.1037/0096-1523.34.5.1129
   SERGENT J, 1984, BRIT J PSYCHOL, V75, P221
   Simion F, 2007, PROG BRAIN RES, V164, P169, DOI 10.1016/S0079-6123(07)64009-6
   Simion F, 2002, DEVELOPMENTAL SCI, V5, P427, DOI 10.1111/1467-7687.00237
   Tanaka J. W., ATTENTION J IN PRESS
   Tanaka JW, 2011, DEVELOPMENTAL SCI, V14, P762, DOI 10.1111/j.1467-7687.2010.01023.x
   Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
   Taylor MJ, 2001, NEUROREPORT, V12, P1671, DOI 10.1097/00001756-200106130-00031
   Turati C, 2002, DEV PSYCHOL, V38, P875, DOI 10.1037//0012-1649.38.6.875
   Wheeler A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018621
   Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
   Xu B., 2013, J VISION, V13
   Yovel G, 2004, NEURON, V44, P889, DOI 10.1016/j.neuron.2004.11.018
NR 51
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-0965
EI 1096-0457
J9 J EXP CHILD PSYCHOL
JI J. Exp. Child Psychol.
PD AUG
PY 2014
VL 124
BP 36
EP 49
DI 10.1016/j.jecp.2014.01.001
PG 14
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA AJ4KX
UT WOS:000337646300003
PM 24747157
ER

PT J
AU Henderson, V
   Davidson, J
   Hemsworth, K
   Edwards, S
AF Henderson, Victoria
   Davidson, Joyce
   Hemsworth, Katie
   Edwards, Sophie
TI Hacking the master code: cyborg stories and the boundaries of autism
SO SOCIAL & CULTURAL GEOGRAPHY
LA English
DT Article
DE cyborg; autism; disability; technology; normalcy; Internet
ID GEOGRAPHIES; INTERNET; ONLINE; SPACES; UNDERSTANDINGS; COMMUNICATION;
   INFORMATION; DISABILITY; SPECTRUM; IDENTITY
AB In this paper, we consider how the use of Internet technologies by individuals on the autism spectrum (AS) may contribute to recoding the spatial, sociopolitical, ontological, and epistemological boundaries commonly assumed to delimit autistic from non-autistic lifeworlds. Drawing on the work of Donna Haraway, we argue that the responses of AS individuals to a survey about online communication suggest these individuals are engaged in a form of cyborg writing, admixing constraints and opportunities in a way that opens alternative, polycentric, and indeterminate but nonetheless important political possibilities for people on (and off) the AS.
C1 [Henderson, Victoria; Davidson, Joyce; Hemsworth, Katie; Edwards, Sophie] Queens Univ, Dept Geog, Kingston, ON K7L 3N6, Canada.
RP Henderson, V (reprint author), Queens Univ, Dept Geog, Mackintosh Corry Hall,Room D201, Kingston, ON K7L 3N6, Canada.
EM victoria.henderson@queensu.ca
CR Alexander Jonathan, 2002, INT J SEXUALITY GEND, V7, P77, DOI 10.1023/A:1015821431188
   Armstrong T., 2010, NEURODIVERSITY DISCO
   Baker D. L., 2011, POLITICS NERODIVERSI
   Benford P., 2009, J ASSISTIVE TECHNOLO, V3, P44, DOI DOI 10.1108/17549450200900015
   Biever C., 2007, NEW SCI, V2610, P26
   Bowker N., 2003, J COMPUTER MEDIATED, V8
   Brownlow C, 2006, MENT RETARD, V44, P315, DOI 10.1352/0047-6765(2006)44[315:CAAIAV]2.0.CO;2
   Bull Michael, 2007, SOUND MOVES IPOD CUL
   Bumiller K, 2008, SIGNS, V33, P967, DOI 10.1086/528848
   Carter D., 2005, Information Communication & Society, V8, DOI 10.1080/13691180500146235
   Centers for Disease Control and Prevention, 2013, AUT SPECTR DIS ASDS
   Chau T., 2006, POSTER PRESENTATION
   Cherney J. L., 1999, ARGUMENTATION ADVOCA, V36, P22
   Clarke J, 2007, DISABIL SOC, V22, P761, DOI 10.1080/09687590701659618
   Collins P., 2004, NOT EVEN WRONG FATHE
   Crang M., 2011, COMPANION SOCIAL GEO, P401
   Crooks V., 2006, ACME INT E J CRITICA, V5, P50
   Davidson J, 2010, CAN GEOGR-GEOGR CAN, V54, P462, DOI 10.1111/j.1541-0064.2010.00309.x
   Davidson J, 2010, SOC CULT GEOGR, V11, P155, DOI 10.1080/14649360903525240
   Davidson J, 2008, SOC CULT GEOGR, V9, P791, DOI 10.1080/14649360802382586
   Davidson J, 2010, SOC SCI MED, V70, P305, DOI 10.1016/j.socscimed.2009.10.017
   Davidson J, 2009, ENVIRON PLANN D, V27, P898, DOI 10.1068/d4308
   Davidson J., 2013, WORLDS AUSTISM ACROS
   Davidson J, 2007, GENDER PLACE CULT, V14, P659, DOI 10.1080/09663690701659135
   Davis Lennard J., 2002, BENDING OVER BACKWAR
   Dekker M., 2006, AUTISTIC CULTURE
   Dobransky K., 2006, Information Communication & Society, V9, DOI 10.1080/13691180600751298
   Dorn M., 1998, PLACES BODY, P136
   Dorn M., 1994, THESIS U PENNSYLVANI
   Gane N, 2006, THEOR CULT SOC, V23, P135, DOI 10.1177/0263276406069228
   Gerland G, 2003, REAL PERSON LIFE OUT
   Ghaziuddin M, 2010, J AUTISM DEV DISORD, V40, P1146, DOI 10.1007/s10803-010-0969-z
   Goffman E., 1963, BEHAV PUBLIC PLACES
   Goggin G., 2006, INFORM COMMUNICATION, V9, P309, DOI DOI 10.1080/13691180600751272
   Goodley Dan, 2011, DISABILITY STUDIES I
   Grandin T., 2013, WIRED
   Hansen N, 2007, TIJDSCHR ECON SOC GE, V98, P493, DOI 10.1111/j.1467-9663.2007.00417.x
   Hansen N., 2009, APORIA, V3, P28
   Haraway D., 2000, CYBERCULTURES READER, P291
   Haraway D, 1997, MODEST WITNESS 2 MIL
   Haraway Donna, 1991, SIMIANS CYBORGS WOME
   Haraway Donna, 2003, COMPANION SPECIES MA
   Hayles N. Katherine, 1999, WE BECAME POSTHUMAN
   Jones R. S. P., 2001, J LEARNING DISABILIT, V5, P35, DOI DOI 10.1177/146900470100500104
   Jones RSP, 2001, DISABIL SOC, V16, P393
   Katz JE, 2002, PERPETUAL CONTACT MO
   Kirby A., 2009, DIGIMODERNISM NEW TE
   Kozel S, 2007, LEONARDO SER, P1
   Madsen M., 2008, TECHNOLOGY JUST IN T
   McVeigh T., 2011, GUARDIAN
   Moss P., 2002, FEMINIST GEOGRAPHY P
   Moustakas C., 1994, PHENOMENOLOGICAL RES
   Munnik R., 2009, BOUNDARIES MONOTHEIS, P106, DOI 10.1163/ej.9789004173163.i-250.38
   Murray S, 2012, AUTISM
   Murray S., WORLDS AUTISM SPECTR
   O'Neill J. L., 1998, EYES ALIENS BOOK AUS
   Osteen M, 2008, ROUTL RES CULT MEDIA, P1
   Parr H, 2002, ENVIRON PLANN D, V20, P73, DOI 10.1068/d411
   Pile S., 2005, REAL CITIES MODERNIT
   Plant S., 1995, CYBERSPACE CYBERBODI, P45
   Prince-Hughes Dawn, 2004, SONGS GORILLA NATION
   Quinlan M. M., 2009, J RES SPECIAL ED NEE, V9, P48
   Reeve D, 2012, DISABILITY AND SOCIAL THEORY: NEW DEVELOPMENTS AND DIRECTIONS, P91
   Sacks O., 1995, ANTHROPOLOGIST MARS
   Selwyn N, 2004, NEW MEDIA SOC, V6, P341, DOI 10.1177/1461444804042519
   Seymour W, 2004, DISABIL SOC, V19, P291, DOI 10.1080/09687590410001689421
   Shields R, 2006, THEOR CULT SOC, V23, P209, DOI 10.1177/0263276406069233
   Silberman S., 2012, WIRED
   Sinclair J., 2010, DISABILITY STUDIES Q, V30
   Sinclair J., 1999, WHY I DISLIKE PERSON
   Singer Judy, 1999, DISABILITY DISCOURSE, V1999, P59
   Thomson Rosemarie Garland, 1997, EXTRAORDINARY BODIES
   Thrift N., 2005, KNOWING CAPITALISM, P153
   Valentine G, 2008, SOC CULT GEOGR, V9, P469, DOI 10.1080/14649360802175691
   Valentine G, 2009, INFORM COMMUN SOC, V12, P44, DOI 10.1080/13691180802158573
   Wakeford N., 2000, CYBERCULTURES READER, P350
   Wilson MW, 2009, GENDER PLACE CULT, V16, P499, DOI 10.1080/09663690903148390
   Wilton RD, 1998, GEOFORUM, V29, P173, DOI 10.1016/S0016-7185(98)00005-0
   Wright K., 2005, J COMPUT-MEDIAT COMM, V10, DOI [10.1111/j.1083-6101.2005.tb00259.x, DOI 10.1111/J.1083-6101.2005.TB00259.X]
NR 79
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1464-9365
EI 1470-1197
J9 SOC CULT GEOGR
JI Soc. Cult. Geogr.
PD AUG
PY 2014
VL 15
IS 5
BP 504
EP 524
DI 10.1080/14649365.2014.898781
PG 21
WC Geography
SC Geography
GA AJ3TK
UT WOS:000337590100002
ER

PT J
AU Brosnan, M
   Hollinworth, M
   Antoniadou, K
   Lewton, M
AF Brosnan, Mark
   Hollinworth, Melissa
   Antoniadou, Konstantina
   Lewton, Marcus
TI Is Empathizing intuitive and Systemizing deliberative?
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Empathizing; Systemizing; E-S theory; Intuition; Deliberation; Dual
   process theory
ID HIGH-FUNCTIONING AUTISM; NORMAL SEX-DIFFERENCES; MALE BRAIN THEORY;
   ASPERGER-SYNDROME; INDIVIDUAL-DIFFERENCES; EMOTION RECOGNITION; SPECTRUM
   DISORDERS; FACIAL EXPRESSIONS; DECISION-MAKING; ADULTS
AB This is the first study to explore the relationship between Empathizing-Systemizing (E-S) theory that provides an account of sex differences in human cognition and dual process theories of cognition. 68 Undergraduates undertook both performance and self-report assessments of Empathizing, intuition, Systemizing and deliberation. A fast (500 ms) and slow (5000 ms) version of the Reading the Mind in the Eyes Task (RMET) was included to explore the effects of rapid presentation on emotional stimuli. Consistent with E-S theory, sex differences were found in Empathizing (favouring females) and Systemizing (favouring males). Females were also found to be more intuitive and males more deliberative for performance, but not self-report, assessments of intuition and deliberation. Empathizing significantly positively correlated with intuition and negatively with deliberation. Conversely. Systemizing significantly positively correlated with deliberation and negatively with intuition (trend). This pattern was replicated in a study of 65 participants from the general population. The exception was the RMET which had no significant sex differences or correlates (fast or slow). The implications for considering both dual process theories of cognition and E-S theory are discussed, with a focus upon the implications for Autism Spectrum Disorder and psychosis. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Brosnan, Mark; Hollinworth, Melissa; Lewton, Marcus] Univ Bath, Bath BA2 7AY, Avon, England.
   [Antoniadou, Konstantina] Maastricht Univ, NL-6200 MD Maastricht, Netherlands.
RP Brosnan, M (reprint author), Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
EM M.J.Brosnan@Bath.ac.uk
CR Allman JM, 2005, TRENDS COGN SCI, V9, P367, DOI 10.1016/j.tics.2005.06.008
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47
   Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
   Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
   Brosnan M, 2013, PSYCHOSIS, V5, P71, DOI 10.1080/17522439.2011.626526
   Brosnan M, 2010, PERS INDIV DIFFER, V49, P738, DOI 10.1016/j.paid.2010.06.018
   Brosnan M, 2014, J AUTISM DEV DISORD, V44, P513, DOI 10.1007/s10803-013-1897-5
   Brosnan MJ, 2012, J AUTISM DEV DISORD, V42, P2491, DOI 10.1007/s10803-012-1505-0
   Clark TF, 2008, EMOTION, V8, P803, DOI 10.1037/a0014124
   Costa Jr P. T., 1992, MANUAL REVISED NEO P
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   De Martino B, 2008, J NEUROSCI, V28, P10746, DOI 10.1523/JNEUROSCI.2895-08.2008
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Epstein S, 1996, J PERS SOC PSYCHOL, V71, P390, DOI 10.1037/0022-3514.71.2.390
   Evans JSBT, 2008, ANNU REV PSYCHOL, V59, P255, DOI 10.1146/annurev.psych.59.103006.093629
   Evans JST, 2013, PERSPECT PSYCHOL SCI, V8, P223, DOI 10.1177/1745691612460685
   Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8
   Frederick S, 2005, J ECON PERSPECT, V19, P25, DOI 10.1257/089533005775196732
   Kahneman D., 2011, THINKING FAST SLOW
   Nettle D, 2007, BRIT J PSYCHOL, V98, P237, DOI 10.1348/000712606X117612
   Patton JH, 1995, J CLIN PSYCHOL, V51, P768, DOI 10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1
   Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
   Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
   Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P187, DOI 10.1007/s10803-006-0151-9
   Stanovich KE, 2000, BEHAV BRAIN SCI, V23, P645, DOI 10.1017/S0140525X00003435
   Stanovich KE, 2008, J PERS SOC PSYCHOL, V94, P672, DOI 10.1037/0022-3514.94.4.672
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
   van Honk J., 2013, PNAS, V108, P3448
   Wakabayashi A, 2006, PERS INDIV DIFFER, V41, P929, DOI 10.1016/j.paid.2006.03.017
   Walsh J. A., 2013, J AUTISM DEV DISORDE
NR 38
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD AUG
PY 2014
VL 66
BP 39
EP 43
DI 10.1016/j.paid.2014.03.006
PG 5
WC Psychology, Social
SC Psychology
GA AI9OO
UT WOS:000337262100009
ER

PT J
AU Dockrell, JE
   Ricketts, J
   Charman, T
   Lindsay, G
AF Dockrell, Julie E.
   Ricketts, Jessie
   Charman, Tony
   Lindsay, Geoff
TI Exploring writing products in students with language impairments and
   autism spectrum disorders
SO LEARNING AND INSTRUCTION
LA English
DT Article
DE Written text production; Language impairment; ASD; Transcription; Text
   generation
ID CURRICULUM-BASED MEASURES; MIDDLE SCHOOL STUDENTS; WRITTEN LANGUAGE;
   LEARNING-DISABILITIES; WORKING-MEMORY; ORAL LANGUAGE; AGE-CHILDREN;
   EXPRESSION; SKILLS; INSTRUCTION
AB Oral language skills scaffold written text production; students with oral language difficulties often experience writing problems. The current study examines the ways in which oral language problems experienced by students with language impairment (LI) and students with autism spectrum disorders (ASD) impact on their production of written text. One hundred and fifty seven participants (M-age = 10;2) with LI or ASD completed standardized measures of oral language, transcription, working memory, and nonverbal ability and produced a written narrative text assessed for productivity, grammatical accuracy, and quality. Measures of transcription, productivity, and grammatical accuracy, but not text quality, were poorer for students with LI. Transcription skills accounted for the majority of variance in the writing of the LI cohort. For the ASD cohort, handwriting, oral language and autism symptomatology were significant predictors. When students with ASD also experienced language problems, their performance was equivalent to that observed in the LI cohort. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Dockrell, Julie E.] Univ London, Inst Educ, Dept Psychol & Human Dev, London WC1E 7HU, England.
   [Ricketts, Jessie] Univ Reading, Inst Educ, Reading RG6 2AH, Berks, England.
   [Charman, Tony] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England.
   [Lindsay, Geoff] Univ Warwick, CEDAR, Coventry CV4 7AL, W Midlands, England.
RP Dockrell, JE (reprint author), Inst Educ, 25 Woburn Sq, London WC1H 0AL, England.
EM julie.dockrell@ioe.ac.uk
CR Abbott R. D., 1993, J ED PSYCHOL, V85
   Adams AM, 2013, BRIT J EDUC PSYCHOL, V83, P76, DOI 10.1111/j.2044-8279.2011.02056.x
   Alloway T. P., 2007, AUTOMATED WORKING ME
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
   Asaro-Saddler K, 2012, TOP LANG DISORD, V32, P361, DOI 10.1097/TLD.0b013e318271813f
   Barnes JL, 2009, AUTISM RES, V2, P148, DOI 10.1002/aur.79
   Barnett A., 2007, DETAILED ASSESSMENT
   Beers SF, 2011, READ WRIT, V24, P183, DOI 10.1007/s11145-010-9264-9
   Berninger V. W., 1994, ADV COGNITION ED PRA, V2, P1
   Berninger VW, 2000, TOP LANG DISORD, V20, P65
   BERNINGER VW, 1995, LEARN DISABILITY Q, V18, P293, DOI 10.2307/1511235
   Berninger VW, 2006, DEV NEUROPSYCHOL, V29, P61, DOI 10.1207/s15326942dn2901_5
   Bishop D. V. M., 2005, TEST RECEPTION GRAMM
   Bishop DVM, 2009, INT J LANG COMM DIS, V44, P600, DOI 10.1080/13682820802259662
   Bishop DVM, 2006, CURR DIR PSYCHOL SCI, V15, P217, DOI 10.1111/j.1467-8721.2006.00439.x
   Broc L, 2013, RES DEV DISABIL, V34, P3253, DOI 10.1016/j.ridd.2013.06.025
   Brown HM, 2011, J AUTISM DEV DISORD, V41, P1464, DOI 10.1007/s10803-010-1168-7
   Capps I, 2000, J ABNORM CHILD PSYCH, V28, P193
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Cragg L., 2006, ED PSYCHOL, V26, P55, DOI 10.1080/01443410500340991
   Datchuk SM, 2013, REM SPEC EDUC, V34, P180, DOI 10.1177/0741932512448254
   Dockrell J. E., 2014, HDB LANGUAGE LITERAC
   Dockrell J. E., 2013, J RES READING
   Dockrell JE, 2009, EXCEPT CHILDREN, V75, P427
   Dunn L. M., 2009, BRIT PICTURE VOCABUL, V3rd
   Elliott C., 1997, BRIT ABILITY SCALES
   Weismer SE, 2013, FOLIA PHONIATR LOGO, V65, P68, DOI 10.1159/000353896
   Espin C, 2000, J SPEC EDUC, V34, P140, DOI 10.1177/002246690003400303
   Espin CA, 2005, J SPEC EDUC, V38, P208, DOI 10.1177/00224669050380040201
   Gansle KA, 2006, SCHOOL PSYCHOL REV, V35, P435
   Gansle KA, 2004, PSYCHOL SCHOOLS, V41, P291, DOI 10.1002/pits.10166
   GILLAM RB, 1992, J SPEECH HEAR RES, V35, P1303
   Graham S, 2008, READ WRIT, V21, P1, DOI 10.1007/s11145-007-9069-7
   Graham S, 1997, J EDUC PSYCHOL, V89, P170, DOI 10.1037/0022-0663.89.1.170
   Graham S., 2009, LEARNING DISABILITIE, V24, P58, DOI [10.1111/j.1540-5826.2009.01277.x, DOI 10.1111/J.1540-5826.2009.01277.X]
   Graham S, 2002, J EDUC PSYCHOL, V94, P669, DOI 10.1037//0022-0663.94.4.669
   Green L, 2003, J EDUC PSYCHOL, V95, P752, DOI 10.1037/0022-0663.95.4.752
   Hellinckx T, 2013, RES AUTISM SPECT DIS, V7, P176, DOI 10.1016/j.rasd.2012.08.009
   Kellogg R. T., 2008, J WRITING RES, V1, P1
   King D, 2013, INT J LANG COMM DIS, V48, P522, DOI 10.1111/1460-6984.12025
   Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
   Kushki A, 2011, J AUTISM DEV DISORD, V41, P1706, DOI 10.1007/s10803-011-1206-0
   Mackie C, 2004, J SPEECH LANG HEAR R, V47, P1469, DOI 10.1044/1092-4388(2004/109)
   Mackie CJ, 2013, READ WRIT, V26, P865, DOI 10.1007/s11145-012-9396-1
   McCarthy JH, 2012, CLIN LINGUIST PHONET, V26, P791, DOI 10.3109/02699206.2012.702185
   McMaster K, 2007, J SPEC EDUC, V41, P68, DOI 10.1177/00224669070410020301
   Montgomery JW, 2010, AM J SPEECH-LANG PAT, V19, P78, DOI 10.1044/1058-0360(2009/09-0028)
   Myles BS, 2003, EDUC TRAIN MENT RET, V38, P362
   Nation K, 2006, J AUTISM DEV DISORD, V36, P911, DOI 10.1007/s10803-006-0130-1
   Nelson N., 2007, READ WRIT Q, V23, P287, DOI DOI 10.1080/10573560701277807
   Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
   Olive T, 2009, LEARN INSTR, V19, P299, DOI 10.1016/j.learninstruc.2008.05.005
   Olive T, 2008, APPL PSYCHOLINGUIST, V29, P669, DOI 10.1017/S0142716408080284
   Pennington RC, 2012, FOCUS AUTISM DEV DIS, V27, P158, DOI 10.1177/1088357612451318
   Puranik CS, 2008, AM J SPEECH-LANG PAT, V17, P107, DOI 10.1044/1058-0360(2008/012)
   Puranik CS, 2012, READ WRIT, V25, P1523, DOI 10.1007/s11145-011-9331-x
   Rust J., 1993, WESCHLER OBJECTIVE R
   Saddler B, 2008, J SPEC EDUC, V42, P79, DOI 10.1177/0022466907310371
   Saddler B, 2013, READ WRIT Q, V29, P20, DOI 10.1080/10573569.2013.741945
   Semel E., 2006, CLIN EVALUATION LANG, V4th
   Semel E. M., 2000, CLIN EVALUATION LANG
   Shanahan T., 2006, HDB WRITING RES, P171
   Taylor LJ, 2012, J AUTISM DEV DISORD, V42, P2067, DOI 10.1007/s10803-012-1456-5
   TINDAL G, 1989, J SPEC EDUC, V23, P169
   Tomblin B, 2011, INT J LANG COMM DIS, V46, P127, DOI 10.1111/j.1460-6984.2011.00017.x
   Troia GA, 2003, J EDUC PSYCHOL CONS, V14, P75, DOI 10.1207/S1532768XJEPC1401_04
   Troia GA, 2011, TOP LANG DISORD, V31, P40, DOI 10.1097/TLD.0b013e31820a0b71
   Wagner RK, 2011, READ WRIT, V24, P203, DOI 10.1007/s11145-010-9266-7
   Wechsler D., 2005, WECHSLER INDIVIDUAL
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Williams GJ, 2013, INT J LANG COMM DIS, V48, P160, DOI 10.1111/1460-6984.12010
   Windsor J, 2000, J SPEECH LANG HEAR R, V43, P1322
   World Health Organization, 1993, MENT DIS GLOSS GUID
NR 74
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0959-4752
J9 LEARN INSTR
JI Learn Instr.
PD AUG
PY 2014
VL 32
BP 81
EP 90
DI 10.1016/j.learninstruc.2014.01.008
PG 10
WC Education & Educational Research; Psychology, Educational
SC Education & Educational Research; Psychology
GA AG0NJ
UT WOS:000335111900008
ER

PT J
AU Gonzalez-Gadea, ML
   Tripicchio, P
   Rattazzi, A
   Baez, S
   Marino, J
   Roca, M
   Manes, F
   Ibanez, A
AF Luz Gonzalez-Gadea, Maria
   Tripicchio, Paula
   Rattazzi, Alexia
   Baez, Sandra
   Marino, Julian
   Roca, Maria
   Manes, Facundo
   Ibanez, Agustin
TI Inter-individual cognitive variability in children with Asperger's
   syndrome
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE individual variability; fluid intelligence; theory of mind; executive
   functions; Asperger's syndrome
ID HIGH-FUNCTIONING AUTISM; OSTERRIETH COMPLEX FIGURE; PERVASIVE
   DEVELOPMENTAL DISORDER; FRONTAL-LOBE LESIONS; MULTIPLE CASE SERIES;
   SPECTRUM DISORDERS; FLUID INTELLIGENCE; EXECUTIVE FUNCTION; DISEMBEDDING
   PERFORMANCE; PARIETAL CORTEX
AB Multiple studies have tried to establish the distinctive profile of individuals with Asperger's syndrome (AS). However, recent reports suggest that adults with AS feature heterogeneous cognitive profiles. The present study explores inter-individual variability in children with AS through group comparison and multiple case series analysis. All participants completed an extended battery including measures of fluid and crystallized intelligence, executive functions, theory of mind, and classical neuropsychological tests. Significant group differences were found in theory of mind and other domains related to global information processing. However, the AS group showed high inter-individual variability (both sub- and supra-normal performance) on most cognitive tasks. Furthermore, high fluid intelligence correlated with less general cognitive impairment, high cognitive flexibility, and speed of motor processing. In light of these findings, we propose that children with AS are characterized by a distinct, uneven pattern of cognitive strengths and weaknesses.
C1 [Luz Gonzalez-Gadea, Maria; Tripicchio, Paula; Rattazzi, Alexia; Baez, Sandra; Roca, Maria; Manes, Facundo; Ibanez, Agustin] Favaloro Univ, Inst Cognit Neurol, Lab Expt Psychol & Neurosci, Buenos Aires, DF, Argentina.
   [Luz Gonzalez-Gadea, Maria; Baez, Sandra; Roca, Maria; Manes, Facundo; Ibanez, Agustin] Natl Sci & Tech Res Council, Buenos Aires, DF, Argentina.
   [Luz Gonzalez-Gadea, Maria; Baez, Sandra; Roca, Maria; Manes, Facundo; Ibanez, Agustin] Diego Portales Univ, UDP INECO Fdn Core Neurosci, Santiago, Chile.
   [Baez, Sandra] Univ Catolica Argentina, Buenos Aires, DF, Argentina.
   [Marino, Julian] Univ Nacl Cordoba, Fac Psicol, RA-5000 Cordoba, Argentina.
   [Manes, Facundo; Ibanez, Agustin] Australian Res Council, Ctr Excellence Cognit & Its Disorders, Sydney, NSW, Australia.
   [Manes, Facundo; Ibanez, Agustin] Univ Autonoma Caribe, Barranquilla, Colombia.
RP Ibanez, A (reprint author), Favaloro Univ, Inst Cognit Neurol, Lab Expt Psychol & Neurosci, Pacheco de Melo 1854-60 C1126AAB, Buenos Aires, DF, Argentina.
EM aibanez@ineco.org.ar
FU CONICET; CONICYT/FONDECYT Regular [1130920, 1140114]; FONCyT-PICT
   [2012-0412, 2012-1309]; INECO Foundation; Fiat Foundation
FX This work was partially supported by grants from CONICET,
   CONICYT/FONDECYT Regular (1130920 and 1140114), FONCyT-PICT 2012-0412,
   FONCyT-PICT 2012-1309, the INECO Foundation, and Fiat Foundation. The
   authors thank Asociacion Asperger Argentina, Ernesto Walhberg, and Sofia
   Peluffo for helping with the patient recruitment process.
CR Adam W., 1990, WIDE RANGE ACHIEVEME
   Ambery FZ, 2006, AUTISM, V10, P551, DOI 10.1177/1362361306068507
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   Baez S, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00302
   Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Bennetto L, 1996, CHILD DEV, V67, P1816, DOI 10.1111/j.1467-8624.1996.tb01830.x
   Bolte S, 2008, J AM ACAD CHILD PSY, V47, P719, DOI 10.1097/CHI.0b013e31816c42bd
   Bowie CR, 2006, NAT PROTOC, V1, P2277, DOI 10.1038/nprot.2006.390
   Bowler DM, 2008, J AUTISM DEV DISORD, V38, P104, DOI 10.1007/s10803-007-0366-4
   Brooks BL, 2006, CLIN NEUROPSYCHOL, V20, P230, DOI 10.1080/13854040590947461
   Brunsdon VEA, 2014, AUTISM, V18, P17, DOI 10.1177/1362361313499456
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Chen F, 2008, RES AUTISM SPECT DIS, V2, P739, DOI 10.1016/j.rasd.2008.03.003
   Chen F, 2010, RES AUTISM SPECT DIS, V4, P457, DOI 10.1016/j.rasd.2009.11.002
   Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   de Jonge M, 2009, EUR CHILD ADOLES PSY, V18, P197, DOI 10.1007/s00787-008-0708-6
   DUNCAN J, 1995, NEUROPSYCHOLOGIA, V33, P261, DOI 10.1016/0028-3932(94)00124-8
   Dunn L. M., 1981, PEABODY PICTURE VOCA
   Durdiakova J, 2014, MOL AUTISM, V5, DOI 10.1186/2040-2392-5-25
   Fugard AJB, 2011, AUTISM, V15, P327, DOI 10.1177/1362361310371798
   Gilbert SJ, 2009, BRAIN, V132, P869, DOI 10.1093/brain/awn365
   Girardot AM, 2012, ENCEPHALE, V38, P488, DOI 10.1016/j.encep.2012.01.013
   Gonzalez-Gadea ML, 2013, RES DEV DISABIL, V34, P817, DOI 10.1016/j.ridd.2012.11.009
   Gray JR, 2003, NAT NEUROSCI, V6, P316, DOI 10.1038/nn1014
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hayashi M, 2008, BRAIN COGNITION, V66, P306, DOI 10.1016/j.bandc.2007.09.008
   Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
   Huepe D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024858
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   Kaland N, 2007, AUTISM, V11, P81, DOI 10.1177/1362361307070988
   Kaland N, 2008, J AUTISM DEV DISORD, V38, P1112, DOI 10.1007/s10803-007-0496-8
   Kaland N, 2008, J AUTISM DEV DISORD, V38, P1161, DOI 10.1007/s10803-007-0474-1
   Kaland N, 2002, J CHILD PSYCHOL PSYC, V43, P517, DOI 10.1111/1469-7610.00042
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Kleinhans N, 2005, DEV NEUROPSYCHOL, V27, P379, DOI 10.1207/s15326942dn2703_5
   KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Koyama T, 2008, PSYCHIAT CLIN NEUROS, V62, P691, DOI 10.1111/j.1440-1819.2008.01871.x
   Kuschner ES, 2009, AUTISM RES, V2, P348, DOI 10.1002/aur.101
   Lee KH, 2006, NEUROIMAGE, V29, P578, DOI 10.1016/j.neuroimage.2005.07.036
   Le Sourn-Bissaoui S, 2011, RES AUTISM SPECT DIS, V5, P648, DOI 10.1016/j.rasd.2010.07.012
   Liss M, 2001, J CHILD PSYCHOL PSYC, V42, P261, DOI 10.1017/S0021963001006679
   Luna B, 2002, NEUROLOGY, V59, P834
   Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036
   Minshew J., 2001, J CHILD PSYCHOL PSYC, V42, P1095, DOI [10.1111/1469-7610.00808, DOI 10.1111/1469-7610.00808]
   Minshew NJ, 1998, MENT RETARD DEV D R, V4, P129, DOI 10.1002/(SICI)1098-2779(1998)4:2<129::AID-MRDD10>3.0.CO;2-X
   Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x
   MOTTRON L, 1993, BRAIN COGNITION, V23, P279, DOI 10.1006/brcg.1993.1060
   Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071
   Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
   Ogino T, 2009, BRAIN DEV-JPN, V31, P52, DOI 10.1016/j.braindev.2008.07.003
   Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Ponnet KS, 2004, AUTISM, V8, P249, DOI 10.1177/1362361304045214
   PRIOR M, 1990, J AUTISM DEV DISORD, V20, P581, DOI 10.1007/BF02216063
   Raven J. C., 2008, TEST MATRICES PROGRE
   Raven J. C., 1992, RAVEN MANUAL
   Rey A., 1959, TEST COPIE FIGURE CO
   Roca M, 2010, BRAIN, V133, P234, DOI 10.1093/brain/awp269
   Roca M, 2012, PSYCHOL MED, V42, P2445, DOI 10.1017/S0033291712000451
   Schlooz WAJM, 2006, J AUTISM DEV DISORD, V36, P1025, DOI 10.1007/s10803-006-0140-z
   Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007
   Semrud-Clikeman M, 2010, J AUTISM DEV DISORD, V40, P1017, DOI 10.1007/s10803-010-0951-9
   SHALLICE T, 1978, CORTEX, V14, P294
   Shimoni HN, 2012, PSYCHIAT RES, V197, P85, DOI 10.1016/j.psychres.2012.02.021
   Smith BJ, 2007, J AUTISM DEV DISORD, V37, P445, DOI 10.1007/s10803-006-0180-4
   Soulieres I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025372
   Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831
   Spearman C, 1904, AM J PSYCHOL, V15, P201, DOI 10.2307/1412107
   Spek AA, 2010, J AUTISM DEV DISORD, V40, P280, DOI 10.1007/s10803-009-0860-y
   Spek AA, 2008, J AUTISM DEV DISORD, V38, P782, DOI 10.1007/s10803-007-0446-5
   Spreen E., 2006, COMPENDIUM NEUROPSYC
   Spreen O, 1969, Cortex, V5, P170
   Torralva T, 2011, PSYCHIAT RES, V186, P261, DOI 10.1016/j.psychres.2010.08.007
   Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028
   Tremont G, 2000, CLIN NEUROPSYCHOL, V14, P295, DOI 10.1076/1385-4046(200008)14:3;1-P;FT295
   Van Eylen L, 2011, RES AUTISM SPECT DIS, V5, P1390, DOI 10.1016/j.rasd.2011.01.025
   Watanabe K, 2005, BRAIN DEV-JPN, V27, P564, DOI 10.1016/j.braindev.2005.02.007
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Willcutt Erik G., 2008, V24, P195, DOI 10.1159/000118526
   Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0
   Woolgar A, 2010, P NATL ACAD SCI USA, V107, P14899, DOI 10.1073/pnas.1007928107
   Zalla T, 2009, J AUTISM DEV DISORD, V39, P373, DOI 10.1007/s10803-008-0634-y
NR 92
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JUL 31
PY 2014
VL 8
AR 575
DI 10.3389/fnhum.2014.00575
PG 11
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AN5CM
UT WOS:000340606900001
PM 25132817
ER

PT J
AU Dore, AS
   Okrasa, K
   Patel, JC
   Serrano-Vega, M
   Bennett, K
   Cooke, RM
   Errey, JC
   Jazayeri, A
   Khan, S
   Tehan, B
   Weir, M
   Wiggin, GR
   Marshall, FH
AF Dore, Andrew S.
   Okrasa, Krzysztof
   Patel, Jayesh C.
   Serrano-Vega, Maria
   Bennett, Kirstie
   Cooke, Robert M.
   Errey, James C.
   Jazayeri, Ali
   Khan, Samir
   Tehan, Ben
   Weir, Malcolm
   Wiggin, Giselle R.
   Marshall, Fiona H.
TI Structure of class C GPCR metabotropic glutamate receptor 5
   transmembrane domain
SO NATURE
LA English
DT Article
ID PROTEIN-COUPLED RECEPTORS; ALLOSTERIC MODULATORS; HEPTAHELICAL DOMAIN;
   MEMBRANE-PROTEINS; CRYSTAL-STRUCTURE; BINDING POCKETS; CONFORMATION;
   ACTIVATION; FAMILY; THERMOSTABILIZATION
AB Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate. Structural studies have been restricted to the amino-terminal extracellular domain, providing little understanding of the membrane-spanning signal transduction domain. Metabotropic glutamate receptor 5 is of considerable interest as a drug target in the treatment of fragile X syndrome, autism, depression, anxiety, addiction and movement disorders. Here we report the crystal structure of the transmembrane domain of the human receptor in complex with the negative allosteric modulator, mavoglurant. The structure provides detailed insight into the architecture of the transmembrane domain of class C receptors including the precise location of the allosteric binding site within the transmem-branedomain and key micro-switches which regulate receptor signalling. This structure also provides a model for all class CG-protein-coupled receptors and may aid in the design of new small-molecule drugs for the treatment of brain disorders.
C1 [Dore, Andrew S.; Okrasa, Krzysztof; Patel, Jayesh C.; Serrano-Vega, Maria; Bennett, Kirstie; Cooke, Robert M.; Errey, James C.; Jazayeri, Ali; Khan, Samir; Tehan, Ben; Weir, Malcolm; Wiggin, Giselle R.; Marshall, Fiona H.] Heptares Therapeut Ltd, Welwyn Garden City AL7 3AX, Herts, England.
RP Marshall, FH (reprint author), Heptares Therapeut Ltd, BioPk,Broadwater Rd, Welwyn Garden City AL7 3AX, Herts, England.
EM fiona.marshall@heptares.com
CR Adams PD, 2010, ACTA CRYSTALLOGR D, V66, P213, DOI 10.1107/S0907444909052925
   Ballesteros J. A., 1995, METH NEUROSCI, V25, P366, DOI DOI 10.1016/S1043-9471(05)80049-7
   Ballesteros JA, 2000, BIOPHYS J, V79, P2754
   Beqollari D, 2009, MOL PHARMACOL, V76, P992, DOI 10.1124/mol.109.058628
   Binet V, 2007, J BIOL CHEM, V282, P12154, DOI 10.1074/jbc.M611071200
   Brauner-Osborne H, 2007, CURR DRUG TARGETS, V8, P169, DOI 10.2174/138945007779315614
   Caffrey M, 2009, NAT PROTOC, V4, P706, DOI 10.1038/nprot.2009.31
   Chang WH, 2000, J BIOL CHEM, V275, P19955, DOI 10.1074/jbc.M909613199
   Chen VB, 2010, ACTA CRYSTALLOGR D, V66, P12, DOI 10.1107/S0907444909042073
   Conn PJ, 2009, NAT REV DRUG DISCOV, V8, P41, DOI 10.1038/nrd2760
   El Moustaine D, 2012, P NATL ACAD SCI USA, V109, P16342, DOI 10.1073/pnas.1205838109
   Emsley P, 2010, ACTA CRYSTALLOGR D, V66, P486, DOI 10.1107/S0907444910007493
   Fredriksson R, 2003, MOL PHARMACOL, V63, P1256, DOI 10.1124/mol.63.6.1256
   Gasparini F, 2002, BIOORG MED CHEM LETT, V12, P407, DOI 10.1016/S0960-894X(01)00767-3
   Goudet C, 2004, P NATL ACAD SCI USA, V101, P378, DOI 10.1073/pnas.0304699101
   Gregory KJ, 2013, MOL PHARMACOL, V83, P991, DOI 10.1124/mol.112.083949
   Hofmann KP, 2009, TRENDS BIOCHEM SCI, V34, P540, DOI 10.1016/j.tibs.2009.07.005
   Hollenstein K, 2013, NATURE, V499, P438, DOI 10.1038/nature12357
   Hu JX, 2007, J CELL MOL MED, V11, P908, DOI 10.1111/j.1582-4934.2007.00096.x
   Kabsch W, 2010, ACTA CRYSTALLOGR D, V66, P125, DOI 10.1107/S0907444909047337
   Katritch V, 2012, TRENDS PHARMACOL SCI, V33, P17, DOI 10.1016/j.tips.2011.09.003
   Kawate T, 2006, STRUCTURE, V14, P673, DOI 10.1016/j.str.2006.01.013
   Kunishima N, 2000, NATURE, V407, P971
   Lebon G, 2011, J MOL BIOL, V409, P298, DOI 10.1016/j.jmb.2011.03.075
   Leslie AGW, 2007, NATO SCI SER II MATH, V245, P41, DOI 10.1007/978-1-4020-6316-9_4
   Levenga J, 2011, NEUROBIOL DIS, V42, P311, DOI 10.1016/j.nbd.2011.01.022
   Li Guiying, 2013, Pharm Pat Anal, V2, P767, DOI 10.4155/ppa.13.58
   Malherbe P, 2003, MOL PHARMACOL, V64, P823, DOI 10.1124/mol.64.4.823
   Malherbe P, 2006, J NEUROCHEM, V98, P601, DOI 10.1111/j.1471-4159.2006.03886.x
   Mccoy AJ, 2007, J APPL CRYSTALLOGR, V40, P658, DOI 10.1107/S0021889807021206
   Murshudov GN, 2011, ACTA CRYSTALLOGR D, V67, P355, DOI 10.1107/S0907444911001314
   O'Brien JA, 2003, MOL PHARMACOL, V64, P731, DOI 10.1124/mol.64.3.731
   Pagano A, 2000, J BIOL CHEM, V275, P33750, DOI 10.1074/jbc.M006230200
   Pin JP, 2003, PHARMACOL THERAPEUT, V98, P325, DOI 10.1016/S0163-7258(03)00038-X
   Rasmussen SGF, 2011, NATURE, V477, P549, DOI 10.1038/nature10361
   Robertson N, 2011, NEUROPHARMACOLOGY, V60, P36, DOI 10.1016/j.neuropharm.2010.07.001
   Rosenbaum DM, 2009, NATURE, V459, P356, DOI 10.1038/nature08144
   Scheerer P, 2008, NATURE, V455, P497, DOI 10.1038/nature07330
   Schwartz TW, 2006, ANNU REV PHARMACOL, V46, P481, DOI 10.1146/annurev.pharmtox.46.120604.141218
   Serrano-Vega MJ, 2008, P NATL ACAD SCI USA, V105, P877, DOI 10.1073/pnas.0711253105
   Shibata Y, 2009, J MOL BIOL, V390, P262, DOI 10.1016/j.jmb.2009.04.068
   SHIGEMOTO R, 1993, NEUROSCI LETT, V163, P53, DOI 10.1016/0304-3940(93)90227-C
   Siu FY, 2013, NATURE, V499, P444, DOI 10.1038/nature12393
   Soding J, 2005, BIOINFORMATICS, V21, P951, DOI 10.1093/bioinformatics/bti125
   Stauffer SR, 2011, ACS CHEM NEUROSCI, V2, P450, DOI 10.1021/cn2000519
   Tsuchiya D, 2002, P NATL ACAD SCI USA, V99, P2660, DOI 10.1073/pnas.052708599
   Venkatakrishnan AJ, 2013, NATURE, V494, P185, DOI 10.1038/nature11896
   Wang C, 2013, NATURE, V497, P338, DOI 10.1038/nature12167
   Winn MD, 2011, ACTA CRYSTALLOGR D, V67, P235, DOI 10.1107/S0907444910045749
   Wu HX, 2014, SCIENCE, V344, P58, DOI 10.1126/science.1249489
NR 50
TC 32
Z9 33
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD JUL 30
PY 2014
VL 511
IS 7511
BP 557
EP +
DI 10.1038/nature13396
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM0VT
UT WOS:000339566300027
PM 25042998
ER

PT J
AU Pirooznia, M
   Kramer, M
   Parla, J
   Goes, FS
   Potash, JB
   McCombie, WR
   Zandi, PP
AF Pirooznia, Mehdi
   Kramer, Melissa
   Parla, Jennifer
   Goes, Fernando S.
   Potash, James B.
   McCombie, W. Richard
   Zandi, Peter P.
TI Validation and assessment of variant calling pipelines for
   next-generation sequencing
SO HUMAN GENOMICS
LA English
DT Article
DE Variant calling pipelines; Next-generation sequencing; Exome sequencing
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; EXOME; TOOL; CANCER;
   INDIVIDUALS; ASSOCIATION; CONCORDANCE; DISCOVERY; FRAMEWORK
AB Background: The processing and analysis of the large scale data generated by next-generation sequencing (NGS) experiments is challenging and is a burgeoning area of new methods development. Several new bioinformatics tools have been developed for calling sequence variants from NGS data. Here, we validate the variant calling of these tools and compare their relative accuracy to determine which data processing pipeline is optimal.
   Results: We developed a unified pipeline for processing NGS data that encompasses four modules: mapping, filtering, realignment and recalibration, and variant calling. We processed 130 subjects from an ongoing whole exome sequencing study through this pipeline. To evaluate the accuracy of each module, we conducted a series of comparisons between the single nucleotide variant (SNV) calls from the NGS data and either gold-standard Sanger sequencing on a total of 700 variants or array genotyping data on a total of 9,935 single-nucleotide polymorphisms. A head to head comparison showed that Genome Analysis Toolkit (GATK) provided more accurate calls than SAMtools (positive predictive value of 92.55% vs. 80.35%, respectively). Realignment of mapped reads and recalibration of base quality scores before SNV calling proved to be crucial to accurate variant calling. GATK HaplotypeCaller algorithm for variant calling outperformed the UnifiedGenotype algorithm. We also showed a relationship between mapping quality, read depth and allele balance, and SNV call accuracy. However, if best practices are used in data processing, then additional filtering based on these metrics provides little gains and accuracies of >99% are achievable.
   Conclusions: Our findings will help to determine the best approach for processing NGS data to confidently call variants for downstream analyses. To enable others to implement and replicate our results, all of our codes are freely available at http://metamoodics.org/wes.
C1 [Pirooznia, Mehdi; Goes, Fernando S.; Zandi, Peter P.] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Kramer, Melissa; Parla, Jennifer; McCombie, W. Richard] Cold Spring Harbor Lab, Stanley Inst Cognit Genom, Woodbury, NY 11797 USA.
   [Potash, James B.] Univ Iowa, Sch Med, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
   [McCombie, W. Richard] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA.
   [Zandi, Peter P.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA.
RP Zandi, PP (reprint author), Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
EM pzandi@jhsph.edu
FU NIH [R01MH087979, R01MH087992, K01MH093809]
FX This project is supported by the NIH funding from R01MH087979 (JBP),
   R01MH087992 (WRM), and K01MH093809 (MP).
CR Bi C, 2012, HUM MUTAT, V33, P1635, DOI 10.1002/humu.22174
   Clement NL, 2010, BIOINFORMATICS, V26, P38, DOI 10.1093/bioinformatics/btp614
   DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
   Gordon D, 1998, GENOME RES, V8, P195
   Henson J, 2012, PHARMACOGENOMICS, V13, P901, DOI [10.2217/pgs.12.72, 10.2217/PGS.12.72]
   Hodges E, 2007, NAT GENET, V39, P1522, DOI 10.1038/ng.2007.42
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Taber KAJ, 2014, JAMA INTERN MED, V174, P275, DOI 10.1001/jamainternmed.2013.12048
   Koboldt DC, 2009, BIOINFORMATICS, V25, P2283, DOI 10.1093/bioinformatics/btp373
   Korn JM, 2008, NAT GENET, V40, P1253, DOI 10.1038/ng.237
   KROGH A, 1994, J MOL BIOL, V235, P1501, DOI 10.1006/jmbi.1994.1104
   Ku CS, 2012, ANN NEUROL, V71, P5, DOI 10.1002/ana.22647
   Ku CS, 2011, HUM GENET, V129, P351, DOI 10.1007/s00439-011-0964-2
   Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
   Li H, 2008, GENOME RES, V18, P1851, DOI 10.1101/gr.078212.108
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
   Li RQ, 2009, GENOME RES, V19, P1124, DOI 10.1101/gr.088013.108
   Li RQ, 2008, BIOINFORMATICS, V24, P713, DOI 10.1093/bioinformatics/btn025
   Liu Q, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-S8-S8
   Liu XT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075619
   Luo Ruibang, 2012, Gigascience, V1, P18, DOI 10.1186/2047-217X-1-18
   McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
   Morris JA, 2012, BIOINFORMATICS, V28, P3320, DOI 10.1093/bioinformatics/bts609
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nishida N, 2008, BMC GENOMICS, V9, DOI 10.1186/1471-2164-9-431
   O'Rawe J, 2013, GENOME MED, V5, DOI 10.1186/gm432
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Panoutsopoulou K, 2013, HUM MOL GENET, V22, pR16, DOI 10.1093/hmg/ddt376
   Parla JS, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-9-r97
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Rees E, 2012, SCHIZOPHRENIA BULL, V38, P377, DOI 10.1093/schbul/sbs047
   Ross JS, 2011, AM J CLIN PATHOL, V136, P527, DOI 10.1309/AJCPR1SVT1VHUGXW
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Smith EN, 2009, MOL PSYCHIATR, V14, P755, DOI 10.1038/mp.2009.43
   Vignot S, 2013, J CLIN ONCOL, V31, P2167, DOI 10.1200/JCO.2012.47.7737
   Wang QG, 2013, GENOME MED, V5, DOI 10.1186/gm495
   Wang Zuoheng, 2013, Frontiers in Genetics, V4, P160, DOI 10.3389/fgene.2013.00160
   Wei Z, 2011, NUCLEIC ACIDS RES, V39, DOI 10.1093/nar/gkr599
NR 38
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1473-9542
EI 1479-7364
J9 HUM GENOMICS
JI Hum. Genomics
PD JUL 30
PY 2014
VL 8
AR 14
DI 10.1186/1479-7364-8-14
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA AN9YB
UT WOS:000340964300001
PM 25078893
ER

PT J
AU Lozano, R
   Hagerman, RJ
   Duyzend, M
   Budimirovic, DB
   Eichler, EE
   Tassone, F
AF Lozano, Reymundo
   Hagerman, Randi J.
   Duyzend, Michael
   Budimirovic, Dejan B.
   Eichler, Evan E.
   Tassone, Flora
TI Genomic studies in fragile X premutation carriers
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Premutation; FMR1 gene; Autism; Second hit; ASD; Neurodevelopmental
   disorders; Neurological disorders
ID COPY NUMBER VARIATION; FMR1 MESSENGER-RNA; TREMOR/ATAXIA SYNDROME;
   MENTAL-RETARDATION; MITOCHONDRIAL DYSFUNCTION; EXPANDED ALLELES; GENE;
   AUTISM; DISORDERS; SPECTRUM
AB Background: The FMR1 premutation is defined as having 55 to 200 CGG repeats in the 5' untranslated region of the fragile X mental retardation 1 gene (FMR1). The clinical involvement has been well characterized for fragile X-associated tremor/ataxia syndrome (FXTAS) and fragile X-associated primary ovarian insufficiency (FXPOI). The behavior/psychiatric and other neurological manifestations remain to be specified as well as the molecular mechanisms that will explain the phenotypic variability observed in individuals with the FMR1 premutation.
   Methods: Here we describe a small pilot study of copy number variants (CNVs) in 56 participants with a premutation ranging from 55 to 192 repeats. The participants were divided into four different clinical groups for the analysis: those with behavioral problems but no autism spectrum disorder (ASD); those with ASD but without neurological problems; those with ASD and neurological problems including seizures; and those with neurological problems without ASD.
   Results: We found 12 rare CNVs (eight duplications and four deletions) in 11 cases (19.6%) that were not found in approximately 8,000 controls. Three of them were at 10q26 and two at Xp22.3, with small areas of overlap. The CNVs were more commonly identified in individuals with neurological involvement and ASD.
   Conclusions: The frequencies were not statistically significant across the groups. There were no significant differences in the psychometric and behavior scores among all groups. Further studies are necessary to determine the frequency of second genetic hits in individuals with the FMR1 premutation; however, these preliminary results suggest that genomic studies can be useful in understanding the molecular etiology of clinical involvement in premutation carriers with ASD and neurological involvement.
C1 [Lozano, Reymundo; Hagerman, Randi J.; Tassone, Flora] Univ Calif Davis, Med Ctr, MIND Inst, Sacramento, CA 95817 USA.
   [Lozano, Reymundo; Hagerman, Randi J.] Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA.
   [Duyzend, Michael; Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA USA.
   [Budimirovic, Dejan B.] Johns Hopkins Med Inst, Kennedy Krieger Inst, Baltimore, MD 21205 USA.
   [Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
   [Tassone, Flora] Univ Calif Davis, Med Ctr, Dept Biochem & Mol Med, Sacramento, CA 95817 USA.
RP Lozano, R (reprint author), Univ Calif Davis, Med Ctr, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM reymundo.lozano@ucdmc.ucdavis.edu
RI Budimirovic, Dejan/O-7885-2014
OI Budimirovic, Dejan/0000-0001-7263-5134
FU National Institute of Child Health and Human Development (NICHD)
   [HD02274, HD036071]
FX We would like to thank Gary Latham, Aia E Jonch, Andrea Schneider,
   Melanie Rothfuss, Kirin Basuta and Cristina Lozano for useful
   discussion. This work was supported by the National Institute of Child
   Health and Human Development (NICHD) grants HD02274, and HD036071. This
   work is dedicated to the memory of Matteo.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bailey JA, 2002, SCIENCE, V297, P1003, DOI 10.1126/science.1072047
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Cao ZY, 2013, J BIOL CHEM, V288, P13831, DOI 10.1074/jbc.M112.441055
   Chen YC, 2010, HUM MOL GENET, V19, P196, DOI 10.1093/hmg/ddp479
   Coffey SM, 2008, AM J MED GENET A, V146A, P1009, DOI 10.1002/ajmg.a.32060
   Cooper JD, 2011, NAT GENET, V43, P838
   Cooper JD, 2008, NAT GENET, V40, P1199
   Cuevas-Covarrubias SA, 2008, BR J DERMATOL
   Cunningham CL, 2011, HUM MOL GENET, V20, P64, DOI 10.1093/hmg/ddq432
   Delbroek H, 2011, EUR J PAEDIATR NEURO, V15, P268, DOI 10.1016/j.ejpn.2010.12.001
   Eichler EE, 2010, NAT REV GENET, V11, P446, DOI 10.1038/nrg2809
   Farzin F, 2006, J DEV BEHAV PEDIATR, V27, pS137, DOI 10.1097/00004703-200604002-00012
   Filipovic-Sadic S, 2010, CLIN CHEM, V56, P399, DOI 10.1373/clinchem.2009.136101
   Fukami M, 2000, AM J HUM GENET, V67, P563, DOI 10.1086/303047
   Garcia-Arocena D, 2010, HUM MOL GENET, V19, P299, DOI 10.1093/hmg/ddp497
   Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
   Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
   Girirajan S, 2013, HUM MOL GENET, V22, P2870, DOI 10.1093/hmg/ddt136
   Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Hagerman R, 2013, LANCET NEUROL, V12, P786, DOI 10.1016/S1474-4422(13)70125-X
   Hessl D, 2011, BIOL PSYCHIAT, V70, P859, DOI 10.1016/j.biopsych.2011.05.033
   Huynh DP, 2000, ANN NEUROL, V48, P737, DOI 10.1002/1531-8249(200011)48:5<737::AID-ANA7>3.0.CO;2-D
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Itsara A, 2010, GENOME RES, V20, P1469, DOI 10.1101/gr.107680.110
   Jacquemont S, 2004, JAMA-J AM MED ASSOC, V291, P460, DOI 10.1001/jama.291.4.460
   Kaplan ES, 2012, J NEUROCHEM, V123, P613, DOI 10.1111/j.1471-4159.2012.07936.x
   Lord C., 2000, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mefford HC, 2009, CURR OPIN GENET DEV, V19, P196, DOI 10.1016/j.gde.2009.04.003
   Napoli E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042504
   Peprah E, 2010, J HUM GENET, V55, P66, DOI 10.1038/jhg.2009.121
   Primerano B, 2002, RNA, V8, P1482, DOI 10.1017/s1355838202020642
   Roid G, 2004, ESSENTIALS STANFORD
   Ross-Inta C, 2010, BIOCHEM J, V429, P545, DOI 10.1042/BJ20091960
   Rothfuss O, 2009, HUM MOL GENET, V18, P3832, DOI 10.1093/hmg/ddp327
   Scheuerle A, 2011, AM J MED GENET B, V156B, P413, DOI 10.1002/ajmg.b.31176
   Sellier C, 2013, CELL REP, V3, P869, DOI 10.1016/j.celrep.2013.02.004
   Sharp AJ, 2006, NAT GENET, V38, P1038, DOI 10.1038/ng1862
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Sullivan AK, 2005, HUM REPROD, V20, P402, DOI 10.1093/humrep/deh635
   Swanson JM, 2001, J AM ACAD CHILD PSY, V40, P168, DOI 10.1097/00004583-200102000-00011
   Tassone F, 2000, AM J HUM GENET, V66, P6, DOI 10.1086/302720
   Tassone F, 2008, J MOL DIAGN, V10, P43, DOI 10.2353/jmoldx.2008.070073
   Tassone F, 2012, GENOME MED, V4, DOI 10.1186/gm401
   Tassone F, 1999, AM J MED GENET, V84, P250, DOI 10.1002/(SICI)1096-8628(19990528)84:3<250::AID-AJMG17>3.0.CO;2-4
   Todd PK, 2013, NEURON, V78, P440, DOI 10.1016/j.neuron.2013.03.026
   Wechsler D., 2008, WECHSLER ADULT INTEL
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   World Health Organisation, 2010, INT STAT CLASS DIS R
   Yatsenko SA, 2009, CLIN GENET, V76, P54, DOI 10.1111/j.1399-0004.2008.01115.x
NR 53
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUL 30
PY 2014
VL 6
AR 27
DI 10.1186/1866-1955-6-27
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AO2PF
UT WOS:000341166500001
PM 25170347
ER

PT J
AU Broek, JAC
   Guest, PC
   Rahmoune, H
   Bahn, S
AF Broek, Jantine A. C.
   Guest, Paul C.
   Rahmoune, Hassan
   Bahn, Sabine
TI Proteomic analysis of post mortem brain tissue from autism patients:
   evidence for opposite changes in prefrontal cortex and cerebellum in
   synaptic connectivity-related proteins
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; Synaptic regulation; Molecular profiling; Post mortem brain;
   Proteome; Selected reaction monitoring mass spectrometry
ID SPECTRUM DISORDERS; FUNCTIONAL CONNECTIVITY; RHESUS-MONKEY;
   WHITE-MATTER; LABEL-FREE; CHILDREN; PROJECTIONS; MYELIN; QUANTIFICATION;
   AUTOANTIBODIES
AB Background: Autism is a neurodevelopmental disorder characterized by impaired language, communication and social skills. Although genetic studies have been carried out in this field, none of the genes identified have led to an explanation of the underlying causes. Here, we have investigated molecular alterations by proteomic profiling of post mortem brain samples from autism patients and controls. The analysis focussed on prefrontal cortex and cerebellum as previous studies have found that these two brain regions are structurally and functionally connected, and they have been implicated in autism.
   Methods: Post mortem prefrontal cortex and cerebellum samples from autism patients and matched controls were analysed using selected reaction monitoring mass spectrometry (SRM-MS). The main objective was to identify significantly altered proteins and biological pathways and to compare these across these two brain regions.
   Results: Targeted SRM-MS resulted in identification of altered levels of proteins related to myelination, synaptic vesicle regulation and energy metabolism. This showed decreased levels of the immature astrocyte marker vimentin in both brain regions, suggesting a decrease in astrocyte precursor cells. Also, decreased levels of proteins associated with myelination and increased synaptic and energy-related proteins were found in the prefrontal cortex, indicative of increased synaptic connectivity. Finally, opposite directional changes were found for myelination and synaptic proteins in the cerebellum.
   Conclusion: These findings suggest altered structural and/or functional connectivity in the prefrontal cortex and cerebellum in autism patients, as shown by opposite effects on proteins involved in myelination and synaptic function. Further investigation of these findings could help to increase our understanding of the mechanisms underlying autism relating to brain connectivity, with the ultimate aim of facilitating novel therapeutic approaches.
C1 [Broek, Jantine A. C.; Guest, Paul C.; Rahmoune, Hassan; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT, England.
   [Bahn, Sabine] Erasmus MC, Dept Neurosci, NL-3015 GE Rotterdam, Netherlands.
RP Bahn, S (reprint author), Univ Cambridge, Dept Chem Engn & Biotechnol, Tennis Court Rd, Cambridge CB2 1QT, England.
EM sb209@cam.ac.uk
FU Autism Speaks Grant [6009]; Dutch Fund for Economic Structure
   Reinforcement (FES) [0908]
FX This work was funded by Autism Speaks Grant #6009 and the Dutch Fund for
   Economic Structure Reinforcement (FES) under grant agreement number 0908
   (NeuroBasic PharmaPhenomics project).
CR Aebersold R, 2013, MOL CELL PROTEOMICS, V12, P2381, DOI 10.1074/mcp.E113.031658
   Allen G, 2005, NEUROIMAGE, V28, P39, DOI 10.1016/j.neuroimage.2005.06.013
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Brady ST, 1999, J NEUROSCI, V19, P7278
   BRODAL P, 1978, BRAIN, V101, P251, DOI 10.1093/brain/101.2.251
   Broek JAC, 2014, INT J NEUROPSYCHOPH, V17, P651, DOI 10.1017/S146114571300117X
   Clough T, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-S16-S6
   Connolly AM, 2006, BIOL PSYCHIAT, V59, P354, DOI 10.1016/j.biopsych.2005.07.004
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Farina C, 2007, TRENDS IMMUNOL, V28, P138, DOI 10.1016/j.it.2007.01.005
   Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
   Fields RD, 2008, TRENDS NEUROSCI, V31, P361, DOI 10.1016/j.tins.2008.04.001
   Goldberg WA, 2003, J AUTISM DEV DISORD, V33, P607, DOI 10.1023/B:JADD.0000005998.47370.ef
   Griffin NM, 2010, NAT BIOTECHNOL, V28, P83, DOI 10.1038/nbt.1592
   Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hyder Fahmeed, 2009, V489, P3, DOI 10.1007/978-1-59745-543-5_1
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Kern J., 2009, INNOVATIONS AUTISM, V5, P2
   Kozlovskaya GV, 2000, ZH NEVROPATOL PSIKH, V100, P50
   Leggio MG, 2011, CORTEX, V47, P137, DOI 10.1016/j.cortex.2009.08.011
   LEICHNETZ GR, 1984, J COMP NEUROL, V228, P388, DOI 10.1002/cne.902280307
   Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
   Martins-de-Souza Daniel, 2012, BMC Res Notes, V5, P146, DOI 10.1186/1756-0500-5-146
   Maximo JO, 2014, NEUROPSYCHOL REV, V24, P16, DOI 10.1007/s11065-014-9250-0
   MIDDLETON FA, 1994, SCIENCE, V266, P458, DOI 10.1126/science.7939688
   Middleton FA, 2001, J NEUROSCI, V21, P700
   Mostafa GA, 2008, J CHILD NEUROL, V23, P1413, DOI 10.1177/0883073808319321
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Ozonoff S, 2005, AUTISM, V9, P461, DOI 10.1177/1362361305057880
   Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
   Picotti P, 2012, NAT METHODS, V9, P555, DOI [10.1038/nmeth.2015, 10.1038/NMETH.2015]
   Ramsey JM, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-27
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   RITVO ER, 1986, AM J PSYCHIAT, V143, P862
   Rogers Tiffany D, 2013, Front Syst Neurosci, V7, P15, DOI 10.3389/fnsys.2013.00015
   Schmahmann JD, 1997, J NEUROSCI, V17, P438
   SINGH VK, 1993, BRAIN BEHAV IMMUN, V7, P97, DOI 10.1006/brbi.1993.1010
   Sparks BF, 2002, NEUROLOGY, V59, P184
   Sporns O, 2000, CEREB CORTEX, V10, P127, DOI 10.1093/cercor/10.2.127
   Stacy ME, 2013, AUTISM
   Stahl-Zeng J, 2007, MOL CELL PROTEOMICS, V6, P1809, DOI 10.1074/mcp.M700132-MCP200
   STUBBS G, 1995, J AUTISM DEV DISORD, V25, P71, DOI 10.1007/BF02178169
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Surinova S, 2013, NAT PROTOC, V8, P1602, DOI 10.1038/nprot.2013.091
   Sweeten TL, 2004, BIOL PSYCHIAT, V55, P434, DOI 10.1016/j.biopsych.200309.001
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Verly M, 2014, NEUROIMAGE-CLIN, V4, P374, DOI 10.1016/j.nicl.2014.01.008
   Watanabe T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039561
   WILLIAMS RS, 1980, ARCH NEUROL-CHICAGO, V37, P749
   Zikopoulos B, 2013, FRONT HUM NEUROSCI, V7, P1, DOI 10.3389/fnhum.2013.00609
   Zikopoulos B, 2010, J NEUROSCI, V30, P14595, DOI 10.1523/JNEUROSCI.2257-10.2010
NR 53
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUL 30
PY 2014
VL 5
AR 41
DI 10.1186/2040-2392-5-41
PG 8
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AO2MX
UT WOS:000341158700002
PM 25126406
ER

PT J
AU Vasu, MM
   Anitha, A
   Thanseem, I
   Suzuki, K
   Yamada, K
   Takahashi, T
   Wakuda, T
   Iwata, K
   Tsujii, M
   Sugiyama, T
   Mori, N
AF Vasu, Mahesh Mundalil
   Anitha, Ayyappan
   Thanseem, Ismail
   Suzuki, Katsuaki
   Yamada, Kohei
   Takahashi, Taro
   Wakuda, Tomoyasu
   Iwata, Keiko
   Tsujii, Masatsugu
   Sugiyama, Toshirou
   Mori, Norio
TI Serum microRNA profiles in children with autism
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; microRNA; complementary DNA; microarray;
   quantitative PCR
ID LYMPHOBLASTOID CELL-LINES; SPECTRUM DISORDERS; EXPRESSION PROFILES;
   SCHIZOPHRENIA; GENE; DISEASES; DYSREGULATION; INDIVIDUALS; CANCER;
   CORTEX
AB Background: As regulators of gene expression, microRNAs (miRNAs) play a key role in the transcriptional networks of the developing human brain. Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. We examined the serum expression profiles of neurologically relevant miRNAs in autism spectrum disorder (ASD), a complex neurodevelopmental disorder characterized by multiple deficits in communication, social interaction and behavior.
   Methods: Total RNA, including miRNA, was extracted from the serum samples of 55 individuals with ASD and 55 age-and sex-matched control subjects, and the mature miRNAs were selectively converted into cDNA. Initially, the expression of 125 mature miRNAs was compared between pooled control and ASD samples. The differential expression of 14 miRNAs was further validated by SYBR Green quantitative PCR of individual samples. Receiver-operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of miRNAs. The target genes and pathways of miRNAs were predicted using DIANA mirPath software.
   Results: Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. Five miRNAs showed good predictive power for distinguishing individuals with ASD. The target genes of these miRNAs were enriched in several crucial neurological pathways.
   Conclusions: This is the first study of serum miRNAs in ASD individuals. The results suggest that a set of serum miRNAs might serve as a possible noninvasive biomarker for ASD.
C1 [Vasu, Mahesh Mundalil; Thanseem, Ismail; Suzuki, Katsuaki; Takahashi, Taro; Wakuda, Tomoyasu; Mori, Norio] Hamamatsu Univ Sch Med, Dept Psychiat, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
   [Anitha, Ayyappan; Yamada, Kohei; Tsujii, Masatsugu; Mori, Norio] Hamamatsu Univ Sch Med, Res Ctr Child Mental Dev, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
   [Iwata, Keiko] Univ Fukui, Res Ctr Child Mental Dev, Fukui 9101193, Japan.
   [Tsujii, Masatsugu] Chukyo Univ, Fac Sociol, Toyota 4700393, Japan.
   [Sugiyama, Toshirou] Hamamatsu Univ Sch Med, Dept Child & Adolescent Psychiat, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
RP Suzuki, K (reprint author), Hamamatsu Univ Sch Med, Dept Psychiat, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan.
EM k-suzuki@hama-med.ac.jp
FU Takeda Science Foundation; Ministry of Education, Culture, Sports,
   Science and Technology of Japan
FX We thank Mses. Mika Oyaizu and Tae Takahashi for their technical
   assistance. This work was supported by the Takeda Science Foundation. It
   was also supported in part by a Grant-in-Aid for 'Integrated Research on
   Neuropsychiatric Disorders' carried out under the Strategic Research
   Program for Brain Sciences from the Ministry of Education, Culture,
   Sports, Science and Technology of Japan. None of these funding sources
   played any role in the design and conduct of the study; the collection,
   management, analysis, and interpretation of the data; or the
   preparation, review, or approval of the manuscript.
CR Abu-Elneel K, 2008, NEUROGENETICS, V9, P153, DOI 10.1007/s10048-008-0133-5
   Ambros V, 2004, NATURE, V431, P350, DOI 10.1038/nature02871
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1997, US GUID STRUCT CLIN
   Anitha A, 2013, BRAIN PATHOL, V23, P294, DOI 10.1111/bpa.12002
   Autism and Developmental Disabilities Monitoring (ADDM) Network, 2012, FUN CTR DIS CONTR PR
   Beveridge NJ, 2010, MOL PSYCHIATR, V15, P1176, DOI 10.1038/mp.2009.84
   Beveridge NJ, 2012, NEUROBIOL DIS, V46, P263, DOI 10.1016/j.nbd.2011.12.029
   Chen X, 2008, CELL RES, V18, P997, DOI 10.1038/cr.2008.282
   Cortez MA, 2009, EXPERT OPIN BIOL TH, V9, P703, DOI [10.1517/14712590902932889 , 10.1517/14712590902932889]
   Cristino AS, 2014, MOL PSYCHIATR, V19, P294, DOI 10.1038/mp.2013.16
   Delcuve GP, 2009, J CELL PHYSIOL, V219, P243, DOI 10.1002/jcp.21678
   Fabian MR, 2010, ANNU REV BIOCHEM, V79, P351, DOI 10.1146/annurev-biochem-060308-103103
   Hanke Merle, 2010, Urol Oncol, V28, P655, DOI 10.1016/j.urolonc.2009.01.027
   Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
   Huntzinger E, 2011, NAT REV GENET, V12, P99, DOI 10.1038/nrg2936
   Kosik KS, 2006, NAT REV NEUROSCI, V7, P911, DOI 10.1038/nrn2037
   Lai CY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021635
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Meek SE, 2013, PSYCHOL REV, V120, P497, DOI 10.1037/a0033139
   Miyake K, 2012, ADV EXP MED BIOL, V724, P91, DOI 10.1007/978-1-4614-0653-2_7
   Moreau MP, 2011, BIOL PSYCHIAT, V69, P188, DOI 10.1016/j.biopsych.2010.09.039
   Okada K, 2007, PROG NEURO-PSYCHOPH, V31, P187, DOI 10.1016/j.pnpbp.2006.08.020
   Park NJ, 2009, CLIN CANCER RES, V15, P5473, DOI 10.1158/1078-0432.CCR-09-0736
   Persico AM, 2013, BEHAV BRAIN RES, V251, P95, DOI 10.1016/j.bbr.2013.06.012
   Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63
   Santarelli DM, 2011, BIOL PSYCHIAT, V69, P180, DOI 10.1016/j.biopsych.2010.09.030
   Sarachana T, 2010, GENOME MED, V2, DOI 10.1186/gm144
   Seno MMG, 2011, BRAIN RES, V1380, P85, DOI 10.1016/j.brainres.2010.09.046
   Shi WT, 2012, J PSYCHIATR RES, V46, P198, DOI 10.1016/j.jpsychires.2011.09.010
   Suda S, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-14
   Talebizadeh Z, 2008, AUTISM RES, V1, P240, DOI 10.1002/aur.33
   Wang K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041561
   Wu S, 2010, ONCOGENE, V29, P2302, DOI 10.1038/onc.2010.34
   Ziats MN, 2013, MOL PSYCHIATR, V19, P848, DOI [10.1038/mp.2013.93, DOI 10.1038/MP.2013.93]
   Zubakov D, 2010, INT J LEGAL MED, V124, P217, DOI 10.1007/s00414-009-0402-3
NR 36
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUL 30
PY 2014
VL 5
AR 40
DI 10.1186/2040-2392-5-40
PG 9
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AO2MX
UT WOS:000341158700001
ER

PT J
AU Chang, YS
   Owen, JP
   Desai, SS
   Hill, SS
   Arnett, AB
   Harris, J
   Marco, EJ
   Mukherjee, P
AF Chang, Yi-Shin
   Owen, Julia P.
   Desai, Shivani S.
   Hill, Susanna S.
   Arnett, Anne B.
   Harris, Julia
   Marco, Elysa J.
   Mukherjee, Pratik
TI Autism and Sensory Processing Disorders: Shared White Matter Disruption
   in Sensory Pathways but Divergent Connectivity in Social-Emotional
   Pathways
SO PLOS ONE
LA English
DT Article
ID INFERIOR LONGITUDINAL FASCICULUS; TENSOR IMAGING TRACTOGRAPHY; SPECTRUM
   DISORDER; FUNCTIONAL CONNECTIVITY; HIPPOCAMPO-FUSIFORM;
   AMYGDALO-FUSIFORM; CORPUS-CALLOSUM; CHILDREN; SYSTEM; FMRI
AB Over 90% of children with Autism Spectrum Disorders (ASD) demonstrate atypical sensory behaviors. In fact, hyper- or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment is now included in the DSM-5 diagnostic criteria. However, there are children with sensory processing differences who do not meet an ASD diagnosis but do show atypical sensory behaviors to the same or greater degree as ASD children. We previously demonstrated that children with Sensory Processing Disorders (SPD) have impaired white matter microstructure, and that this white matter microstructural pathology correlates with atypical sensory behavior. In this study, we use diffusion tensor imaging (DTI) fiber tractography to evaluate the structural connectivity of specific white matter tracts in boys with ASD (n = 15) and boys with SPD (n = 16), relative to typically developing children (n = 23). We define white matter tracts using probabilistic streamline tractography and assess the strength of tract connectivity using mean fractional anisotropy. Both the SPD and ASD cohorts demonstrate decreased connectivity relative to controls in parieto-occipital tracts involved in sensory perception and multisensory integration. However, the ASD group alone shows impaired connectivity, relative to controls, in temporal tracts thought to subserve social-emotional processing. In addition to these group difference analyses, we take a dimensional approach to assessing the relationship between white matter connectivity and participant function. These correlational analyses reveal significant associations of white matter connectivity with auditory processing, working memory, social skills, and inattention across our three study groups. These findings help elucidate the roles of specific neural circuits in neurodevelopmental disorders, and begin to explore the dimensional relationship between critical cognitive functions and structural connectivity across affected and unaffected children.
C1 [Chang, Yi-Shin; Owen, Julia P.; Mukherjee, Pratik] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA.
   [Desai, Shivani S.; Hill, Susanna S.; Arnett, Anne B.; Harris, Julia; Marco, Elysa J.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94115 USA.
RP Marco, EJ (reprint author), Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94115 USA.
EM marcoe@neuropeds.ucsf.edu
FU Wallace Research Foundation; Gates Family Foundation; Holcombe Kawaja
   Family Foundation; Simons Foundation; NIH [R01 NS060776, K23 MH083890,
   KL2 RR024130]
FX This work was funded by grants from the Wallace Research Foundation, the
   Gates Family Foundation and the Holcombe Kawaja Family Foundation. EJM,
   JPO and PM acknowledge support from the Simons Foundation. PM also
   acknowledges support from NIH R01 NS060776. EJM has received support
   from NIH K23 MH083890 and KL2 RR024130. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Ahn RR, 2004, AM J OCCUP THER, V58, P287
   Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
   American Psychiatric Association, 1994, AM PSYCH ASS DIAGN S
   Aoki Y, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-25
   Behrens TEJ, 2007, NEUROIMAGE, V34, P144, DOI 10.1016/j.neuroimage.2006.09.018
   Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
   Brett-Green BA, 2008, BRAIN RES, V1242, P283, DOI 10.1016/j.brainres.2008.03.090
   Bundy AC, 2007, AM J OCCUP THER, V61, P201
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   Conturo TE, 2008, J INT NEUROPSYCH SOC, V14, P933, DOI 10.1017/S1355617708081381
   Cuthbert BN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-126
   Danielian LE, 2010, NEUROIMAGE, V49, P1572, DOI 10.1016/j.neuroimage.2009.08.062
   Dunn W, 1997, AM J OCCUP THER, V51, P25
   Dziobek I, 2010, ARCH GEN PSYCHIAT, V67, P397, DOI 10.1001/archgenpsychiatry.2010.31
   Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
   Fischl B, 2012, NEUROIMAGE, V62, P774, DOI 10.1016/j.neuroimage.2012.01.021
   Forkel J, 2012, CORTEX, DOI DOI 10.1016/J.CORTEX.2012.09.005
   Haas BW, 2012, GENES BRAIN BEHAV, V11, P62, DOI 10.1111/j.1601-183X.2011.00733.x
   Jansma H, 2013, NEUROSCIENCE, V256, P230
   Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
   Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
   Jou RJ, 2011, AUST NZ J PSYCHIAT, V45, P153, DOI 10.3109/00048674.2010.534069
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
   Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037
   Koldewyn K, 2014, P NATL ACAD SCI USA, V111, P1981, DOI 10.1073/pnas.1324037111
   Kumar A, 2009, CEREB CORTEX, V20, P2103, DOI DOI 10.1093/CERC0R/BHP278
   Lo YC, 2011, PSYCHIAT RES-NEUROIM, V192, P60, DOI 10.1016/j.pscychresns.2010.09.008
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54
   McGrath J, 2013, AUTISM RES, V6, P307, DOI 10.1002/aur.1290
   Nagy Z, 2004, J COGNITIVE NEUROSCI, V16, P1227, DOI 10.1162/0898929041920441
   Nichols T. E., 2001, HUM BRAIN MAPP, V15, P1, DOI DOI 10.1002/HBM.1058
   Ortibus E, 2012, DEV MED CHILD NEUROL, V54, P38, DOI 10.1111/j.1469-8749.2011.04147.x
   Owen JP, 2013, NEUROIMAGE-CLIN, V2, P844, DOI 10.1016/j.nicl.2013.06.009
   Perou Ruth, 2013, MMWR Surveill Summ, V62 Suppl 2, P1
   Philippi CL, 2009, J NEUROSCI, V29, P15089, DOI 10.1523/JNEUROSCI.0796-09.2009
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x
   Smith CD, 2009, J MAGN RESON IMAGING, V29, P1248, DOI 10.1002/jmri.21692
   Szatmary B, 2010, PLOS COMPUT BIOL, V6
   Tang CY, 2010, INTELLIGENCE, V38, P293, DOI 10.1016/j.intell.2010.03.003
   Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006
   Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
   Wakana S, 2007, NEUROIMAGE, V36, P630, DOI 10.1016/j.neuroimage.2007.02.049
   Wechsler D., 2003, WISC 4 ADM SCORING M
NR 47
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 30
PY 2014
VL 9
IS 7
AR e103038
DI 10.1371/journal.pone.0103038
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM7EZ
UT WOS:000340028800023
PM 25075609
ER

PT J
AU Rabaneda, LG
   Robles-Lanuza, E
   Nieto-Gonzalez, JL
   Scholl, FG
AF Rabaneda, Luis G.
   Robles-Lanuza, Estefania
   Nieto-Gonzalez, Jose Luis
   Scholl, Francisco G.
TI Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior
   in Mice
SO CELL REPORTS
LA English
DT Article
ID SYNAPTIC VESICLE EXOCYTOSIS; MENTAL-RETARDATION; ALPHA-NEUREXINS;
   BETA-NEUREXINS; CELL-ADHESION; MUTATIONS; SYNAPSES; SPECTRUM; GENE;
   NEUROLIGIN-1
AB Autism spectrum disorders (ASDs) comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits. Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early postnatal periods result in aberrant wiring and function of neuronal circuits. Neurexins are synaptic proteins associated with autism. Here, we generated transgenic beta Nrx1 Delta C mice in which neurexin function is selectively impaired during late postnatal stages. Whole-cell recordings in cortical neurons show an impairment of glutamatergic synaptic transmission in the beta Nrx1 Delta C mice. Importantly, mutant mice exhibit autism-related symptoms, such as increased self-grooming, deficits in social interactions, and altered interaction for nonsocial olfactory cues. The autistic-like phenotype of beta Nrx1 Delta C mice can be reversed after removing the mutant protein in aged animals. The defects resulting from disruption of neurexin function after the completion of embryonic and early postnatal development suggest that functional impairment of mature circuits can trigger autism-related phenotypes.
C1 [Rabaneda, Luis G.; Robles-Lanuza, Estefania; Nieto-Gonzalez, Jose Luis; Scholl, Francisco G.] Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville 41013, Spain.
   [Rabaneda, Luis G.; Robles-Lanuza, Estefania; Nieto-Gonzalez, Jose Luis; Scholl, Francisco G.] Univ Seville, Dept Fisiol Med & Biofis, Seville 41013, Spain.
   [Nieto-Gonzalez, Jose Luis] Ctr Invest Biomed Red Enfermedade Meurodegenerat, Seville 41013, Spain.
RP Scholl, FG (reprint author), Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Ave Manuel Siurot S-N, Seville 41013, Spain.
EM fgs@us.es
RI Nieto-Gonzalez, Jose/B-7165-2013
OI Nieto-Gonzalez, Jose/0000-0003-1757-4951
FU NEURONERANET (EUHF-AUTISM) [PIM2010ERN-0070]; Instituto de Salud Carlos
   III [PI111058]; Junta de Andalucia [P11-CVI-7599]; V Plan Propio de
   Investigacion (Universidad de Sevilla); Juan de la Cierva MINECO
   contract
FX Research at the F.G.S. lab was funded by grants from NEURONERANET
   (EUHF-AUTISM, PIM2010ERN-0070), Instituto de Salud Carlos III
   (PI111058), and Junta de Andalucia (P11-CVI-7599). We thank Dr. Leon
   Lagnado (University of Sussex) for the generous gift of the sypHy
   construct, Dr. Oscar Pintado for pronuclear injection, Dr. Angel Barco
   for helpful advice with bitransgenic mice, and Dr. Maria Luz Montesinos
   and Itziar Benito for assistance with some behavioral tests. Technical
   assistance during the generation of transgenic mice was provided by
   Maria Luisa Pecero. The authors wish to thank Drs. Rafael
   Fernandez-Chacon and Amalia Martinez-Mir for support and critical
   reading of the manuscript. E. R-L received a fellowship from V Plan
   Propio de Investigacion (Universidad de Sevilla), and J.L.N.-G is a
   recipient of a Juan de la Cierva MINECO contract. Part of the study was
   performed at CITIUS (Universidad de Sevilla).
CR Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010
   Boucard AA, 2005, NEURON, V48, P229, DOI 10.1016/j.neuron.2005.08.026
   Butz S, 1998, CELL, V94, P773, DOI 10.1016/S0092-8674(00)81736-5
   Camacho-Garcia RJ, 2013, PSYCHIAT GENET, V23, P262, DOI 10.1097/YPG.0000000000000013
   Camacho-Garcia RJ, 2012, NEUROBIOL DIS, V47, P135, DOI 10.1016/j.nbd.2012.03.031
   Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
   Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063
   Choi YB, 2011, NEURON, V70, P468, DOI 10.1016/j.neuron.2011.03.020
   Comoletti D, 2006, BIOCHEMISTRY-US, V45, P12816, DOI 10.1021/bi0614131
   Dean C, 2003, NAT NEUROSCI, V6, P708, DOI 10.1038/nn1074
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Ehrmann I, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003474
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Fairless R, 2008, J NEUROSCI, V28, P12969, DOI 10.1523/JNEUROSCI.5294-07.2008
   Futai K, 2007, NAT NEUROSCI, V10, P186, DOI 10.1038/nn1837
   Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
   Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628
   Gokce O, 2013, J NEUROSCI, V33, P14617, DOI 10.1523/JNEUROSCI.1232-13.2013
   Granseth B, 2006, NEURON, V51, P773, DOI 10.1016/j.neuron.2006.08.029
   Grayton HM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067114
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
   Lau CG, 2012, J NEUROSCI, V32, P8521, DOI 10.1523/JNEUROSCI.1245-12.2012
   Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
   Marco EJ, 2011, PEDIATR RES, V69, p48R, DOI [10.1203/PDR.0b013e3182130c54, 10.1109/SPL.2011.5782616]
   Mayford M, 1996, SCIENCE, V274, P1678, DOI 10.1126/science.274.5293.1678
   McGraw CM, 2011, SCIENCE, V333, P186, DOI 10.1126/science.1206593
   Missler M, 2003, NATURE, V423, P939, DOI 10.1038/nature01755
   Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   PUSCHEL AW, 1995, J NEUROSCI, V15, P2849
   Schaaf CP, 2012, EUR J HUM GENET, V20, P1240, DOI 10.1038/ejhg.2012.95
   Scheiffele P, 2000, CELL, V101, P657, DOI 10.1016/S0092-8674(00)80877-6
   Shepherd GMG, 2013, NAT REV NEUROSCI, V14, P278, DOI 10.1038/nrn3469
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tabuchi K, 2002, GENOMICS, V79, P849, DOI 10.1006/geno.2002.6780
   Treutlein B, 2014, P NATL ACAD SCI USA, V111, pE1291, DOI 10.1073/pnas.1403244111
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   USHKARYOV YA, 1992, SCIENCE, V257, P50, DOI 10.1126/science.1621094
   Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
   Wisniowiecka-Kowalnik B, 2010, AM J MED GENET B, V153B, P983, DOI 10.1002/ajmg.b.31064
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yang M, 2011, CURR PROTOC NEUROSCI, DOI DOI 10.1002/0471142301.NS0826S56.:UNIT
   Yang M., 2009, CURR PROTOC NEUROSCI, DOI [10.1002/0471142301.ns0824s48, DOI 10.1002/0471142301.NS0824S48]
NR 46
TC 1
Z9 1
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD JUL 24
PY 2014
VL 8
IS 2
BP 337
EP 345
DI 10.1016/j.celrep.2014.06.022
PG 9
WC Cell Biology
SC Cell Biology
GA AO7YT
UT WOS:000341569800003
PM 25017069
ER

PT J
AU Pandya, CD
   Pillai, A
AF Pandya, Chirayu D.
   Pillai, Anilkumar
TI TrkB interacts with ErbB4 and regulates NRG1-induced NR2B
   phosphorylation in cortical neurons before synaptogenesis
SO CELL COMMUNICATION AND SIGNALING
LA English
DT Article
DE NRG1; BDNF; TrkB; Neurons; Synapse; NR2B
ID RAT VISUAL-CORTEX; NMDA RECEPTOR; NEUROTROPHIC FACTOR; PREFRONTAL
   CORTEX; SCHIZOPHRENIA; BRAIN; BDNF; EXPRESSION; NEUREGULIN-1; CELLS
AB Background: Neuregulin 1 (NRG1) and NMDARs play important roles in various neuronal functions including neural development. NMDARs also promote many cellular events such as proliferation and survival of neuroblasts before synapse formation. Although many recent studies have indicated that NRG1 regulates NMDAR function in cortical neurons, the effect of NRG1 on NMDAR activation before synapse formation is not well studied.
   Results: NRG1 induces activation of NMDAR subunit NR2B, and tropomyosin- related kinase receptor B (TrkB), the receptor for BDNF via activation of phospholipase C-gamma (PLC-gamma) in immature primary cortical neurons. Our data using TrkB inhibitor (K252a), TrkB siRNA and TrkB-/- neurons demonstrated that TrkB inhibition suppresses NRG1-induced NR2B activation in neurons. We found that NRG1 stimulation leads to GABA(A) receptor-mediated TrkB activation. Co-immunoprecipitation and proximity ligase assay showed that TrkB interacts with ErbB4 (NRG1 receptor) and the TrkB-ErbB4 interaction was increased following NRG1 treatment. A significant reduction in TrkB-ErbB4 interaction was observed in the prefrontal cortex of schizophrenia subjects. We found significant increase in released BDNF levels following NRG1 treatment, which was inhibited by ErbB4 inhibitor, AG1478. In addition, pretreatment with BDNF neutralizing antibody, but not control IgG abolished NRG1- induced increases in phospho-TrkB and phospho-NR2B levels. Moreover, studies using TrkB mutants showed that intercellular domain of TrkB is necessary for TrkB-ErbB4 interaction and NR2B activation.
   Conclusions: BDNF/TrkB signaling plays an important role in the NRG1- stimulated NR2B regulation. These findings could be of relevance to many neurodevelopmental disorders, as NRG1 and BDNF signaling pathways have been implicated in autism and schizophrenia.
C1 [Pandya, Chirayu D.; Pillai, Anilkumar] Georgia Regents Univ, Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30901 USA.
RP Pillai, A (reprint author), Georgia Regents Univ, Med Coll Georgia, Dept Psychiat & Hlth Behav, 997 St Sebastian Way, Augusta, GA 30901 USA.
EM apillai@gru.edu
FU NINDS/NIH; National Multiple Sclerosis Society; Department of Veteran
   Affairs
FX We thank Dr. Chao (New York University School of Medicine, New York) for
   the phospho-TrkB antibody and Dr. Maruyama (Okinawa Institute of Science
   and Technology, Japan) for the TrkB constructs. The authors are thankful
   to Dr. Rohrer (Medical University of South Carolina, SC) for the TrkB
   knockout mice. The authors would also like to acknowledge the Human
   Brain and Spinal Fluid Resource Center, VA West Los Angeles Healthcare
   Center, 11301 Wilshire Blvd. Los Angeles, CA 90073 which is supported by
   NINDS/NIH, National Multiple Sclerosis Society, and Department of
   Veteran Affairs.
CR Bao JX, 2003, J CELL BIOL, V161, P1133, DOI 10.1083/jcb.200212085
   Belforte JE, 2010, NAT NEUROSCI, V13, P76, DOI 10.1038/nn.2447
   Bjarnadottir M, 2007, J NEUROSCI, V27, P4519, DOI 10.1523/JNEUROSCI.4314-06.2007
   Cellerino A, 1996, EUR J NEUROSCI, V8, P1190, DOI 10.1111/j.1460-9568.1996.tb01287.x
   Du J, 2003, J CELL BIOL, V163, P385
   Finkbeiner S, 1997, NEURON, V19, P1031, DOI 10.1016/S0896-6273(00)80395-5
   Gajendran N, 2009, J NEUROSCI, V29, P2404, DOI 10.1523/JNEUROSCI.4303-08.2009
   Gambrill AC, 2011, P NATL ACAD SCI USA, V108, P5855, DOI 10.1073/pnas.1012676108
   Gomez-Casati ME, 2010, P NATL ACAD SCI USA, V107, P17005, DOI 10.1073/pnas.1008938107
   Gu ZL, 2005, J NEUROSCI, V25, P4974, DOI 10.1523/JNEUROSCI.1086-05.2005
   Gurd JW, 1997, J NEUROCHEM, V69, P623
   Hahn CG, 2006, NAT MED, V12, P824, DOI 10.1038/nm1418
   Issa G, 2010, NEUROBIOL DIS, V39, P327, DOI 10.1016/j.nbd.2010.04.017
   Jeanneteau F, 2010, NAT NEUROSCI, V13, P1373, DOI 10.1038/nn.2655
   Jeanneteau F, 2008, P NATL ACAD SCI USA, V105, P4862, DOI 10.1073/pnas.0709102105
   Jeanneteau FD, 2012, P NATL ACAD SCI USA, V109, P1305, DOI 10.1073/pnas.1114122109
   Kim YI, 2006, J NEUROSCI RES, V84, P1512, DOI 10.1002/jnr.21063
   Lai C, 2004, BIOCHEM BIOPH RES CO, V319, P603, DOI 10.1016/j.bbrc.2004.05.027
   Law AJ, 2006, P NATL ACAD SCI USA, V103, P6747, DOI 10.1073/pnas.0602002103
   Lin SY, 1998, MOL BRAIN RES, V55, P20, DOI 10.1016/S0169-328X(97)00349-5
   Liu XH, 2011, J NEUROSCI, V31, P8491, DOI 10.1523/JNEUROSCI.5317-10.2011
   Luk KC, 2004, DEV NEUROSCI-BASEL, V26, P218, DOI 10.1159/000082139
   Mei L, 2008, NAT REV NEUROSCI, V9, P437, DOI 10.1038/nrn2392
   MONYER H, 1994, NEURON, V12, P529, DOI 10.1016/0896-6273(94)90210-0
   Pandya Chirayu D, 2013, Asian J Psychiatr, V6, P22, DOI 10.1016/j.ajp.2012.08.010
   Pillai A, 2008, NEUROSIGNALS, V16, P183, DOI 10.1159/000111562
   Pitcher GM, 2011, NAT MED, V17, P470, DOI 10.1038/nm.2315
   Pizzorusso T, 2000, J NEUROSCI, V20, P2809
   Porcher C, 2011, J BIOL CHEM, V286, P21667, DOI 10.1074/jbc.M110.201582
   RAJKOWSKA G, 1995, CEREB CORTEX, V5, P307, DOI 10.1093/cercor/5.4.307
   Rieff HI, 1999, J NEUROSCI, V19, P10757
   Shen Jianying, 2012, J Mol Signal, V7, P2, DOI 10.1186/1750-2187-7-2
   Simonetti M, 2008, J BIOL CHEM, V283, P18743, DOI 10.1074/jbc.M800296200
   Tan GH, 2012, NAT NEUROSCI, V15, P258, DOI 10.1038/nn.3005
   Ting AK, 2011, J NEUROSCI, V31, P15, DOI 10.1523/JNEUROSCI.2538-10.2011
   Tsai GC, 2002, ANNU REV PHARMACOL, V42, P165, DOI 10.1146/annurev.pharmtox.42.082701.160735
   Villmann C, 2007, NEUROSCIENTIST, V13, P594, DOI 10.1177/1073858406296259
   Washbourne P, 2002, NAT NEUROSCI, V5, P751, DOI 10.1038/nn883
   Weickert CS, 2005, MOL PSYCHIATR, V10, P637, DOI 10.1038/sj.mp.4001678
   Weickert CS, 2003, MOL PSYCHIATR, V8, P592, DOI 10.1038/sj.mp.4001308
   Woo RS, 2007, NEURON, V54, P599, DOI 10.1016/j.neuron.2007.04.009
NR 41
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1478-811X
J9 CELL COMMUN SIGNAL
JI Cell Commun. Signal.
PD JUL 24
PY 2014
VL 12
AR 47
DI 10.1186/s12964-014-0047-9
PG 11
WC Cell Biology
SC Cell Biology
GA AM4RW
UT WOS:000339844000001
PM 25052836
ER

PT J
AU Zhao, H
   Kim, Y
   Park, J
   Park, D
   Lee, SE
   Chang, I
   Chang, S
AF Zhao, Haiyan
   Kim, Yoonju
   Park, Joohyun
   Park, Daehun
   Lee, Sang-Eun
   Chang, Iree
   Chang, Sunghoe
TI SCAMP5 Plays a Critical Role in Synaptic Vesicle Endocytosis during High
   Neuronal Activity
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE neuronal activity; recycling pool; resting pool; SCAMP5; synaptic
   vesicle endocytosis
ID CARRIER MEMBRANE-PROTEIN; HIPPOCAMPAL SYNAPSES; PC12 CELLS; EXOCYTOSIS;
   SYNAPTOPHYSIN; POOL; KINETICS; RELEASE; NEUROTRANSMISSION; TRAFFICKING
AB Secretory carrier membrane protein 5 (SCAMP5), a recently identified candidate gene for autism, is brain specific and highly abundant in synaptic vesicles (SVs), but its function is currently unknown. Here, we found that knockdown (KD) of endogenous SCAMP5 by SCAMP5-specific shRNAs in cultured rat hippocampal neurons resulted in a reduction in total vesicle pool size as well as in recycling pool size, but the recycling/resting pool ratio was significantly increased. SCAMP5 KD slowed endocytosis after stimulation, but impaired it severely during strong stimulation. We also found that KD dramatically lowered the threshold of activity at which SV endocytosis became unable to compensate for the ongoing exocytosis occurring during a stimulus. Reintroducing shRNA-resistant SCAMP5 reversed these endocytic defects. Therefore, our results suggest that SCAMP5 functions during high neuronal activity when a heavy load is imposed on endocytosis. Our data also raise the possibility that the reduction in expression of SCAMP5 in autistic patients may be related to the synaptic dysfunction observed in autism.
C1 [Zhao, Haiyan; Kim, Yoonju; Park, Joohyun; Park, Daehun; Lee, Sang-Eun; Chang, Iree; Chang, Sunghoe] Seoul Natl Univ, Coll Med, Dept Physiol & Biomed Sci, Seoul 110799, South Korea.
   [Zhao, Haiyan; Kim, Yoonju; Park, Joohyun; Park, Daehun; Lee, Sang-Eun; Chang, Sunghoe] Seoul Natl Univ, Coll Med, Biomembrane Plast Res Ctr, Seoul 110799, South Korea.
   [Kim, Yoonju; Park, Joohyun; Chang, Sunghoe] Seoul Natl Univ, Coll Med, Neurosci Res Inst, Med Res Ctr, Seoul 110799, South Korea.
   [Chang, Sunghoe] Seoul Natl Univ, Coll Med, Biomax Inst, Seoul 110799, South Korea.
RP Chang, S (reprint author), Seoul Natl Univ, Coll Med, Dept Physiol, 309 Biomed Sci Bldg,28 Yeongeon Dong, Seoul 110799, South Korea.
EM sunghoe@snu.ac.kr
FU Biomembrane Plasticity Research Center - National Research Foundation of
   Korea [20100029395]
FX This work was supported by the Biomembrane Plasticity Research Center
   funded by the National Research Foundation of Korea (Grant 20100029395
   to S.C.).
CR Balaji J, 2007, P NATL ACAD SCI USA, V104, P20576, DOI 10.1073/pnas.0707574105
   BETZ WJ, 1992, SCIENCE, V255, P200, DOI 10.1126/science.1553547
   Burrone J, 2006, NAT PROTOC, V1, P2970, DOI 10.1038/nprot.2006.449
   Castermans D, 2010, HUM MOL GENET, V19, P1368, DOI 10.1093/hmg/ddq013
   Chang S, 2001, NAT NEUROSCI, V4, P787, DOI 10.1038/90489
   Denker Annette, 2010, Front Synaptic Neurosci, V2, P135, DOI 10.3389/fnsyn.2010.00135
   ESHKIND LG, 1995, CELL TISSUE RES, V282, P423, DOI 10.1007/s004410050493
   Ferguson SM, 2007, SCIENCE, V316, P570, DOI 10.1126/science.1140621
   Fernandez-Alfonso T, 2004, NEURON, V41, P943, DOI 10.1016/S0896-6273(04)00113-8
   Fernandez-Chacon R, 1999, J BIOL CHEM, V274, P32551, DOI 10.1074/jbc.274.46.32551
   Fernandez-Chacon R, 2000, J NEUROSCI, V20, P7941
   Fernandez-Chacon R, 2000, J BIOL CHEM, V275, P12752, DOI 10.1074/jbc.275.17.12752
   Granseth B, 2008, J PHYSIOL-LONDON, V586, P5969, DOI 10.1113/jphysiol.2008.159715
   Guo ZH, 2002, J BIOL CHEM, V277, P35357, DOI 10.1074/jbc.M202259200
   Han CF, 2009, J IMMUNOL, V182, P2986, DOI 10.4049/jimmunol.0802002
   Hua ZL, 2011, NEURON, V71, P474, DOI 10.1016/j.neuron.2011.06.010
   Hubner K, 2002, INT REV CYTOL, V214, P103
   Janz R, 1999, NEURON, V24, P687, DOI 10.1016/S0896-6273(00)81122-8
   Kwon SE, 2011, NEURON, V70, P847, DOI 10.1016/j.neuron.2011.04.001
   Lee S, 2006, EMBO J, V25, P4983, DOI 10.1038/sj.emboj.7601349
   Liao H, 2007, BIOCHEMISTRY-US, V46, P10909, DOI 10.1021/bi701121j
   Liao H, 2008, AM J PHYSIOL-CELL PH, V294, pC797, DOI 10.1152/ajpcell.00493.2007
   Lin PJC, 2005, J CELL SCI, V118, P1885, DOI 10.1242/jcs.02315
   Liu LX, 2005, MOL BIOL CELL, V16, P4463, DOI 10.1091/mbc.E05-03-0231
   Liu LX, 2002, MOL BIOL CELL, V13, P4266, DOI 10.1091/mbc.E02-03-0136
   McMahon HT, 1996, P NATL ACAD SCI USA, V93, P4760, DOI 10.1073/pnas.93.10.4760
   Murthy VN, 1997, NEURON, V18, P599, DOI 10.1016/S0896-6273(00)80301-3
   Murthy VN, 2003, ANNU REV NEUROSCI, V26, P701, DOI 10.1146/annurev.neuro.26.041002.131445
   Noh JY, 2009, J BIOL CHEM, V284, P11318, DOI 10.1074/jbc.M807620200
   Raingo J, 2012, NAT NEUROSCI, V15, P738, DOI 10.1038/nn.3067
   Ramirez DMO, 2012, NEURON, V73, P121, DOI 10.1016/j.neuron.2011.10.034
   Rizzoli SO, 2004, SCIENCE, V303, P2037, DOI 10.1126/science.1094682
   Rizzoli SO, 2005, NAT REV NEUROSCI, V6, P57, DOI 10.1038/nrn1583
   Ryan TA, 2001, CURR OPIN NEUROBIOL, V11, P544, DOI 10.1016/S0959-4388(00)00247-6
   RYAN TA, 1993, NEURON, V11, P713, DOI 10.1016/0896-6273(93)90081-2
   Sankaranarayanan S, 2000, NAT CELL BIOL, V2, P197
   Sankaranarayanan S, 2000, BIOPHYS J, V79, P2199
   Trommershauser J, 2003, BIOPHYS J, V84, P1563
   Voglmaier SM, 2006, NEURON, V51, P71, DOI 10.1016/j.neuron.2006.05.027
   Wu TT, 1998, MOL BIOL CELL, V9, P1661
   Zhang J, 2011, TRAFFIC, V12, P600, DOI 10.1111/j.1600-0854.2011.01170.x
NR 41
TC 1
Z9 1
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JUL 23
PY 2014
VL 34
IS 30
BP 10085
EP 10095
DI 10.1523/JNEUROSCI.2156-14.2014
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AO0LV
UT WOS:000341001600025
PM 25057210
ER

PT J
AU Matsuzaki, J
   Kagitani-Shimono, K
   Sugata, H
   Hirata, M
   Hanaie, R
   Nagatani, F
   Tachibana, M
   Tominaga, K
   Mohri, I
   Taniike, M
AF Matsuzaki, Junko
   Kagitani-Shimono, Kuriko
   Sugata, Hisato
   Hirata, Masayuki
   Hanaie, Ryuzo
   Nagatani, Fumiyo
   Tachibana, Masaya
   Tominaga, Koji
   Mohri, Ikuko
   Taniike, Masako
TI Progressively Increased M50 Responses to Repeated Sounds in Autism
   Spectrum Disorder with Auditory Hypersensitivity: A
   Magnetoencephalographic Study
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; STARTLE CIRCUIT; MEG; SCHIZOPHRENIA; CHILDREN;
   LATERALIZATION; EXCITABILITY; TRANSPORTER; DYSFUNCTION; SEROTONIN
AB The aim of this study was to investigate the differential time-course responses of the auditory cortex to repeated auditory stimuli in children with autism spectrum disorder (ASD) showing auditory hypersensitivity. Auditory-evoked field values were obtained from 21 boys with ASD (12 with and 9 without auditory hypersensitivity) and 15 age-matched typically developing controls. M50 dipole moments were significantly increased during the time-course study only in the ASD with auditory hypersensitivity compared with those for the other two groups. The boys having ASD with auditory hypersensitivity also showed more prolonged response duration than those in the other two groups. The response duration was significantly related to the severity of auditory hypersensitivity. We propose that auditory hypersensitivity is associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons.
C1 [Matsuzaki, Junko; Nagatani, Fumiyo; Tachibana, Masaya; Mohri, Ikuko; Taniike, Masako] Osaka Univ, Grad Sch Med, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, Osaka, Japan.
   [Kagitani-Shimono, Kuriko; Hanaie, Ryuzo; Tachibana, Masaya; Tominaga, Koji; Mohri, Ikuko; Taniike, Masako] Osaka Univ, Grad Sch Med, United Grad Sch Child Dev, Osaka, Japan.
   [Kagitani-Shimono, Kuriko; Tachibana, Masaya; Tominaga, Koji; Mohri, Ikuko; Taniike, Masako] Osaka Univ, Grad Sch Med, Dept Pediat, Osaka, Japan.
   [Sugata, Hisato; Hirata, Masayuki] Osaka Univ, Grad Sch Med, Dept Neurosurg, Osaka, Japan.
RP Kagitani-Shimono, K (reprint author), Osaka Univ, Grad Sch Med, United Grad Sch Child Dev, Osaka, Japan.
EM kuriko@ped.med.osaka-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology (MEXT)
   [23591494]
FX This study was supported by a grant-in-aid for scientific research (No.
   23591494) from Ministry of Education, Culture, Sports, Science and
   Technology (MEXT). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Achenbach TM, 1991, MANUAL CHILD BEHAV C
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Burbach JPH, 2009, TRENDS NEUROSCI, V32, P69, DOI 10.1016/j.tins.2008.11.002
   Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
   Chait M, 2004, NEUROREPORT, V15, P16
   Cheng YW, 2010, NEUROIMAGE, V50, P873, DOI 10.1016/j.neuroimage.2010.01.011
   Curtin PCP, 2013, J NEUROSCI, V33, P10011, DOI 10.1523/JNEUROSCI.4733-12.2013
   Dairoku H, 2004, KOKURITSU TOKUSHU KY, V7, P19
   de Boer M, 2014, RES AUTISM SPECT DIS, V8, P737, DOI 10.1016/j.rasd.2014.03.001
   DILAVORE PC, 1995, J AUTISM DEV DISORD, V25, P355, DOI 10.1007/BF02179373
   Dunn W, 2002, INFANT TODDLER SENSO
   Faith MH, 2005, PSYCHOPHYSIOLOGY, V42, P417
   Gage NM, 2003, DEV BRAIN RES, V144, P201, DOI 10.1016/S0165-3806(03)00172-X
   Guiraud JA, 2011, NEUROREPORT, V22, P845, DOI 10.1097/WNR.0b013e32834c0bec
   Hanaie R, 2013, CEREBELLUM, V12, P645, DOI 10.1007/s12311-013-0475-x
   Itani T, 2001, PSYCHIAT NEUROLOGIA, V41, P243
   Iwata K, 2014, MOL AUTISM, V5, DOI 10.1186/2040-2392-5-33
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Matsuzaki J, 2012, NEUROREPORT, V23, P113, DOI 10.1097/WNR.0b013e32834ebf44
   Medan V, 2011, J NEUROPHYSIOL, V106, P3195, DOI 10.1152/jn.00644.2011
   Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
   Neylan TC, 1999, BIOL PSYCHIAT, V46, P1656, DOI 10.1016/S0006-3223(99)00047-5
   Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63
   Rotschafer S, 2013, BRAIN RES, V1506, P12, DOI 10.1016/j.brainres.2013.02.038
   Shukla DK, 2011, NEUROPSYCHOLOGIA, V49, P1378, DOI 10.1016/j.neuropsychologia.2011.02.022
   Sugata H, 2012, BRAIN RES, V1468, P29, DOI 10.1016/j.brainres.2012.05.053
   Thoma RJ, 2003, AM J PSYCHIAT, V160, P1595, DOI 10.1176/appi.ajp.160.9.1595
   Uda T, 2012, CLIN NEUROPHYSIOL, V123, P1496, DOI 10.1016/j.clinph.2011.12.008
   Yoshimura Y, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-38
NR 31
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 23
PY 2014
VL 9
IS 7
AR e102599
DI 10.1371/journal.pone.0102599
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM1NT
UT WOS:000339614100042
PM 25054201
ER

PT J
AU O'Brien, J
   Spencer, J
   Girges, C
   Johnston, A
   Hill, H
AF O'Brien, Justin
   Spencer, Janine
   Girges, Christine
   Johnston, Alan
   Hill, Harold
TI Impaired Perception of Facial Motion in Autism Spectrum Disorder
SO PLOS ONE
LA English
DT Article
ID TYPICALLY DEVELOPING-CHILDREN; SUPERIOR TEMPORAL SULCUS; BIOLOGICAL
   MOTION; VISUAL-MOTION; UNFAMILIAR FACES; DYNAMIC CHANGES; MOVING FACES;
   RECOGNITION; INVERSION; IDENTITY
AB Facial motion is a special type of biological motion that transmits cues for socio-emotional communication and enables the discrimination of properties such as gender and identity. We used animated average faces to examine the ability of adults with autism spectrum disorders (ASD) to perceive facial motion. Participants completed increasingly difficult tasks involving the discrimination of (1) sequences of facial motion, (2) the identity of individuals based on their facial motion and (3) the gender of individuals. Stimuli were presented in both upright and upside-down orientations to test for the difference in inversion effects often found when comparing ASD with controls in face perception. The ASD group's performance was impaired relative to the control group in all three tasks and unlike the control group, the individuals with ASD failed to show an inversion effect. These results point to a deficit in facial biological motion processing in people with autism, which we suggest is linked to deficits in lower level motion processing we have previously reported.
C1 [O'Brien, Justin; Spencer, Janine; Girges, Christine] Brunel Univ, Dept Psychol, Ctr Res Infant Behav, Uxbridge UB8 3PH, Middx, England.
   [Johnston, Alan] UCL, London, England.
   [Hill, Harold] Univ Wollongong, Sch Psychol, Wollongong, NSW, Australia.
RP Spencer, J (reprint author), Brunel Univ, Dept Psychol, Ctr Res Infant Behav, Uxbridge UB8 3PH, Middx, England.
EM janine.spencer@brunel.ac.uk
CR Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x
   Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   Benton A.L., 1983, CONTRIBUTION NEUROPS
   BERRY D S, 1991, Ecological Psychology, V3, P349, DOI 10.1207/s15326969eco0304_3
   Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
   Braddick O, 2003, NEUROPSYCHOLOGIA, V41, P1769, DOI 10.1016/S0028-3932(03)00178-7
   Brieber S, 2010, NEUROPSYCHOLOGIA, V48, P1644, DOI 10.1016/j.neuropsychologia.2010.02.007
   Christie F, 1998, MEM COGNITION, V26, P780, DOI 10.3758/BF03211397
   Cook J, 2009, NEUROPSYCHOLOGIA, V47, P3275, DOI 10.1016/j.neuropsychologia.2009.07.010
   Cook JL, 2013, BRAIN, V136, P2816, DOI 10.1093/brain/awt208
   Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
   Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218
   Hadjikhani N, 2009, SOC COGN AFFECT NEUR, V4, P70, DOI 10.1093/scan/nsn038
   Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002
   Hill H, 2001, CURR BIOL, V11, P880, DOI 10.1016/S0960-9822(01)00243-3
   HOBSON RP, 1988, PSYCHOL MED, V18, P911
   Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
   Itier RJ, 2002, NEUROIMAGE, V15, P353, DOI 10.1006/nimg.2001.0982
   Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209
   Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
   Knight B, 1997, VIS COGN, V4, P265, DOI 10.1080/713756764
   Koldewyn K, 2011, DEVELOPMENTAL SCI, V14, P1075, DOI 10.1111/j.1467-7687.2011.01058.x
   Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272
   Lander K, 2005, VIS COGN, V12, P429, DOI 10.1080/13506280444000382
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   McKay LS, 2012, NEUROIMAGE, V59, P1524, DOI 10.1016/j.neuroimage.2011.08.033
   Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401
   Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026
   Nackaerts E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044473
   O'Toole AJ, 2002, TRENDS COGN SCI, V6, P261, DOI 10.1016/S1364-6613(02)01908-3
   Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520
   Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
   Pelphrey KA, 2007, SOC COGN AFFECT NEUR, V2, P140, DOI 10.1093/scan/nsm010
   Pilz KS, 2006, EXP BRAIN RES, V171, P436, DOI 10.1007/s00221-005-0283-8
   Raven J., 2003, MANUAL RAVENS PROGR
   Robertson CE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048173
   Rutherford MD, 2012, J AUTISM DEV DISORD, V42, P557, DOI 10.1007/s10803-011-1267-0
   Sato W, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-99
   Sato W, 2013, RES AUTISM SPECT DIS, V7, P906, DOI 10.1016/j.rasd.2013.04.008
   Saygin AP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013491
   Shih P, 2011, BIOL PSYCHIAT, V70, P270, DOI 10.1016/j.biopsych.2011.03.040
   Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031
   Spencer JV, 2006, PERCEPTION, V35, P1047, DOI 10.1068/p5328
   Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027
   Swettenham J, 2013, J AUTISM DEV DISORD, V43, P1437, DOI 10.1007/s10803-012-1699-1
   TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
   Thornton IM, 2002, PERCEPTION, V31, P113, DOI 10.1068/p3300
   Thornton IM, 2011, PSIHOLOGIJA, V44, P5, DOI 10.2298/PSI1101005T
   VALENTINE T, 1988, BRIT J PSYCHOL, V79, P471
   van Boxtel JJA, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00209
   Watson TL, 2005, VIS COGN, V12, P1291, DOI 10.1080/13506280444000526
   Webb SJ, 2012, SOC COGN AFFECT NEUR, V7, P578, DOI 10.1093/scan/nsp002
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
   Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 55
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 23
PY 2014
VL 9
IS 7
AR e102173
DI 10.1371/journal.pone.0102173
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM1NT
UT WOS:000339614100033
PM 25054288
ER

PT J
AU Iijima, K
   Ota, K
AF Iijima, Kazuki
   Ota, Koji
TI How (not) to draw philosophical implications from the cognitive nature
   of concepts: the case of intentionality
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE experimental philosophy; normativism; descriptivism; Knobe effect;
   intentionality; theory of mind
ID MORAL RESPONSIBILITY; ORDINARY LANGUAGE; FOLK INTUITIONS; AUTISM;
   JUDGMENT; MIND
AB Philosophers have often appealed to intuitive judgments in various thought experiments to support or reject particular theses. Experimental philosophy is an emerging discipline that examines the cognitive nature of such intuitive judgments. In this paper, we assess the methodological and epistemological status of experimental philosophy. We focus on the Knobe effect, in which our intuitive judgment of the intentionality of an action seems to depend on the perceived moral status of that action. The debate on the philosophical implications of the Knobe effect has been framed in terms of the distinction between the competence and performance of the concept of intentionality. Some scholars seem to suggest that the Knobe effect reflects the competence (or otherwise, the performance error) of the concept of intentionality. However, we argue that these notions are purely functional and thus do not have philosophical implications, without assuming normativism, which we see as problematic in a psychological methodology. Finally, focusing on the gap between competence and rationality, we suggest future directions for experimental philosophy.
C1 [Iijima, Kazuki] Tamagawa Univ, Brain Sci Inst, Machida, Tokyo 1948610, Japan.
   [Iijima, Kazuki] Japan Soc Promot Sci, Tokyo, Japan.
   [Ota, Koji] Univ Tokyo, Grad Sch Arts Sci, Dept Basic Sci, Tokyo, Japan.
RP Iijima, K (reprint author), Tamagawa Univ, Brain Sci Inst, 6-1-1 Tamagawa Gakuen, Machida, Tokyo 1948610, Japan.
EM iijima.kazuki@14.alumni.u-tokyo.ac.jp
CR Adams F, 2004, ANALYSIS, V64, P173, DOI 10.1111/j.1467-8284.2004.00480.x
   Adams F., 1986, MIND LANG, V1, P281, DOI [10.1111/j.1468-0017.1986.tb00327.x, DOI 10.1111/J.1468-0017.1986.TB00327.X]
   Alexander J., 2012, EXPT PHILOS INTRO
   Blair RJR, 1996, J AUTISM DEV DISORD, V26, P571
   BRATMAN M, 1984, PHILOS REV, V93, P375, DOI 10.2307/2184542
   Carruthers P., 2008, INNATE MIND, V3, P90
   Chalmers D. J., 1996, CONSCIOUS MIND SEARC
   Chomsky N., 1965, ASPECTS THEORY SYNTA
   De Brigard F, 2009, ETHICAL THEORY MORAL, V12, P511, DOI 10.1007/s10677-008-9143-5
   Elqayam S, 2011, BEHAV BRAIN SCI, V34, P233, DOI 10.1017/S0140525X1100001X
   Evans J, 2011, CHEM WORLD-UK, V8, P34
   Friedmann N, 1997, BRAIN LANG, V56, P397, DOI 10.1006/brln.1997.1795
   Gettier E., 1963, ANALYSIS, P121, DOI DOI 10.1093/ANALYS/23.6.121
   Grant CM, 2005, AUTISM, V9, P317, DOI 10.1177/1362361305055418
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Jackendoff R., 2002, FDN LANGUAGE BRAIN M, DOI [10.1093/acprof:oso/9780198270126.001.0001, DOI 10.1093/ACPROF:OSO/9780198270126.001.0001]
   Kinno R, 2009, BRAIN LANG, V110, P71, DOI 10.1016/j.bandl.2009.05.001
   Knobe J, 2003, ANALYSIS, V63, P190, DOI 10.1111/1467-8284.00419
   Knobe J., 2013, EXPT PHILOS, V2
   Knobe J, 2012, ANNU REV PSYCHOL, V63, P81, DOI 10.1146/annurev-psych-120710-100350
   Knobe J., 2008, EXPT PHILOS, P3
   Knobe J, 2006, PHILOS STUD, V130, P203, DOI 10.1007/s11098-004-4510-0
   Kripke S, 1980, NAMING NECESSITY, V2nd
   Leslie AM, 2006, SOC NEUROSCI, V1, P270, DOI 10.1080/17470910600992197
   Leslie AM, 2006, PSYCHOL SCI, V17, P421, DOI 10.1111/j.1467-9280.2006.01722.x
   Mandelbaum E., 2012, REV PHILOS PSYCHOL, V3, P351, DOI DOI 10.1007/S13164-012-0106-3
   Marantz A, 2005, LINGUIST REV, V22, P429, DOI 10.1515/tlir.2005.22.2-4.429
   Marr D., 1982, VISION COMPUTATIONAL
   Nadelhoffer Thomas, 2006, PHILOS EXPLORATIONS, V9, P203, DOI 10.1080/13869790600641905
   Nadelhoffer Thomas, 2004, J THEORETICAL PHILOS, V24, P196, DOI DOI 10.1037/H0091241
   Nahmias E, 2006, PHILOS PHENOMEN RES, V73, P28, DOI 10.1111/j.1933-1592.2006.tb00603.x
   Nahmias E, 2005, PHILOS PSYCHOL, V18, P561, DOI 10.1080/09515080500264180
   Nichols S, 2008, EXPT PHILOS
   Nichols S, 2007, NOUS, V41, P663, DOI 10.1111/j.1468-0068.2007.00666.x
   Ota K., 2014, NAGOYA J PHILOS, V11, P39
   Phillips C., 2013, STUD LINGUIST, V6, P11
   Phillips C, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P241
   SEARLE JR, 1980, BEHAV BRAIN SCI, V3, P417
   Stich S., 1990, FRAGMENTATION REASON
   Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
   Thomasson AL, 2012, MONIST, V95, P175
   van de Koot H., 2010, LINGUISTICS ENTERPRI, P183
   Yang C, 2010, LINGUA, V120, P1160, DOI 10.1016/j.lingua.2008.09.015
   Zalla T., 2011, REV PHILOS PSYCHOL, V2, P681, DOI DOI 10.1007/S13164-011-0048-1
NR 44
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUL 22
PY 2014
VL 5
AR 799
DI 10.3389/fpsyg.2014.00799
PG 5
WC Psychology, Multidisciplinary
SC Psychology
GA AL8NO
UT WOS:000339396200001
PM 25101045
ER

PT J
AU Albertini, B
   Di Sabatino, M
   Melegari, C
   Passerini, N
AF Albertini, Beatrice
   Di Sabatino, Marcello
   Melegari, Cecilia
   Passerini, Nadia
TI Formulating SLMs as oral pulsatile system for potential delivery of
   melatonin to pediatric population
SO INTERNATIONAL JOURNAL OF PHARMACEUTICS
LA English
DT Article
DE Melatonin; Solid-lipid microparticles; Spray congealing; Oral pediatric
   formulation; Dose flexibility; Stability in food
ID CONTROLLED-RELEASE MELATONIN; CHILDREN; SLEEP; DISORDERS; AUTISM;
   MEDICINES; ATOMIZER; ENHANCE
AB The formulation development of melatonin (MLT) for infants and children with neurodevelopmental difficulties was fully investigated. This population have a higher prevalence of sleep disorders and present special challenges for drug administration and swallowing. To solve these issues, solid lipid microparticles (SLMs) were designed to obtain an oral flexible dosage form constituted by GRAS excipients and a free flow pulsatile delivery system for MLT, able to maintain its release through 8 h. Three groups of SLMs were produced by spray congealing and characterized as regards particle size, morphology, flowability, solid state, drug content and release behavior. The SLMs manipulation with milk and yogurt and the MLT stability in these foods were also investigated. Microparticles with different excipient composition were selected to obtain a pulsatile release pattern over 8 h. The final delivery platform displayed a prompt release from group I SLMs together with a lag phase of groups II and III SLMs, followed by a repeated MLT release from group II and a prolonged MLT release related to the last group. Finally, MLT was compatible and stable in milk and yogurt suggesting that microparticles sprinkled into food is acceptable for MLT administration to children unable to swallow capsules or tablets. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Albertini, Beatrice; Di Sabatino, Marcello; Melegari, Cecilia; Passerini, Nadia] Univ Bologna, Dept Pharm & Biotechnol, I-40127 Bologna, Italy.
RP Albertini, B (reprint author), Univ Bologna, Dept Pharm & Biotechnol, Via San Donato 19-2, I-40127 Bologna, Italy.
EM beatrice.albertini@unibo.it
CR Albertini B, 2009, EUR J PHARM SCI, V36, P591, DOI 10.1016/j.ejps.2008.12.009
   Albertini B, 2013, INT J PHARMACEUT, V440, P238, DOI 10.1016/j.ijpharm.2012.06.004
   Albertini B, 2008, EUR J PHARM BIOPHARM, V69, P348, DOI 10.1016/j.ejpb.2007.09.011
   [Anonymous], 2010, EMA2381995REV, P1
   Brezezinski A., 2005, SLEEP MED REV, V9, P41
   Dawson D, 1996, PHARMACOL THERAPEUT, V69, P15, DOI 10.1016/0163-7258(95)02020-9
   De Leersnyder H, 2011, PEDIATR NEUROL, V45, P23, DOI 10.1016/j.pediatrneurol.2011.02.001
   De Leersnyder H, 2006, TRENDS ENDOCRIN MET, V17, P291, DOI 10.1016/j.tem.2006.07.007
   de Lima VR, 2010, J PINEAL RES, V49, P169, DOI 10.1111/j.1600-079X.2010.00782.x
   Ernest TB, 2012, INT J PHARMACEUT, V435, P124, DOI 10.1016/j.ijpharm.2012.05.070
   European Medicines Agency (EMA)/Committee for Advanced Therapies (CAT), 2012, EMACHMP609792012, P1
   Geoffriau M, 1998, HORM RES, V49, P136, DOI 10.1159/000023160
   Giannotti F, 2006, J AUTISM DEV DISORD, V36, P741, DOI 10.1007/s10803-006-0116-z
   Gitto E, 2011, J PINEAL RES, V50, P21, DOI 10.1111/j.1600-079X.2010.00814.x
   Gringras P, 2012, BMJ-BRIT MED J, V345, P1
   Haus E, 2007, ADV DRUG DELIVER REV, V59, P985, DOI 10.1016/j.addr.2007.01.001
   Herxheimer A, 2002, COCHRANE DB SYST REV, V2, DOI [10.1002/14651858.CD001520, DOI 10.1002/14651858.CD001520]
   Hoebert M, 2009, J PINEAL RES, V47, P1, DOI 10.1111/j.1600-079X.2009.00681.x
   Jan JE, 2000, J PINEAL RES, V29, P34, DOI 10.1034/j.1600-079X.2000.290105.x
   Jan J.E., 2007, CURR PEDIAT REV, V3, P214
   Kotagal S, 2012, PEDIATR NEUROL, V47, P242, DOI 10.1016/j.pediatrneurol.2012.05.007
   Le Barbier C, 2013, INT J PHARMACEUT, V457, P341, DOI 10.1016/j.ijpharm.2013.08.062
   Maroni A, 2010, INT J PHARMACEUT, V398, P1, DOI 10.1016/j.ijpharm.2010.07.026
   Passerini N, 2012, PHYTOMEDICINE, V19, P160, DOI 10.1016/j.phymed.2011.06.027
   Passerini N, 2010, J PHARM SCI-US, V99, P916, DOI 10.1002/jps.21854
   Passerini N, 2006, INT J PHARM, V318, P92, DOI 10.1016/j.ijpharm.2006.03.028
   Politis Stavros N, 2013, Recent Pat Drug Deliv Formul, V7, P87
   Qi S, 2010, J PHARM SCI-US, V99, P262, DOI 10.1002/jps.21832
   Shah T, 2008, DEV MED CHILD NEUROL, V50, P845, DOI 10.1111/j.1469-8749.2008.03092.x
   Strickley R, 2007, J PHARM SCI, V97, P1731
   Wening K, 2011, INT J PHARMACEUT, V404, P1, DOI 10.1016/j.ijpharm.2010.11.001
   Wirojanan J, 2009, J CLIN SLEEP MED, V5, P145
   World Health Organisation (WHO), 2009, INF M DOS FORMS MED
   World Health Organization (WHO), 2007, PREV CARD DIS GUID A, P1
NR 34
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5173
EI 1873-3476
J9 INT J PHARMACEUT
JI Int. J. Pharm.
PD JUL 20
PY 2014
VL 469
IS 1
BP 67
EP 79
DI 10.1016/j.ijpharm.2014.04.055
PG 13
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AH9TZ
UT WOS:000336487500009
PM 24768728
ER

PT J
AU Fan, YT
   Cheng, YW
AF Fan, Yang-Teng
   Cheng, Yawei
TI Atypical Mismatch Negativity in Response to Emotional Voices in People
   with Autism Spectrum Conditions
SO PLOS ONE
LA English
DT Article
ID EVENT-RELATED POTENTIALS; ASPERGER-SYNDROME; FUNCTIONING AUTISM; BRAIN
   POTENTIALS; CHILDREN; SPEECH; PERCEPTION; ATTENTION; DISCRIMINATION;
   DISORDER
AB Autism Spectrum Conditions (ASC) are characterized by heterogeneous impairments of social reciprocity and sensory processing. Voices, similar to faces, convey socially relevant information. Whether voice processing is selectively impaired remains undetermined. This study involved recording mismatch negativity (MMN) while presenting emotionally spoken syllables dada and acoustically matched nonvocal sounds to 20 subjects with ASC and 20 healthy matched controls. The people with ASC exhibited no MMN response to emotional syllables and reduced MMN to nonvocal sounds, indicating general impairments of affective voice and acoustic discrimination. Weaker angry MMN amplitudes were associated with more autistic traits. Receiver operator characteristic analysis revealed that angry MMN amplitudes yielded a value of 0.88 (p<.001). The results suggest that people with ASC may process emotional voices in an atypical fashion already at the automatic stage. This processing abnormality can facilitate diagnosing ASC and enable social deficits in people with ASC to be predicted.
C1 [Fan, Yang-Teng; Cheng, Yawei] Natl Yang Ming Univ, Inst Neurosci, Taipei 112, Taiwan.
   [Fan, Yang-Teng; Cheng, Yawei] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan.
   [Cheng, Yawei] Natl Yang Ming Univ Hosp, Dept Rehabil, Yilan, Taiwan.
   [Cheng, Yawei] Taipei City Hosp, Dept Res & Educ, Taipei, Taiwan.
RP Cheng, YW (reprint author), Natl Yang Ming Univ, Inst Neurosci, Taipei 112, Taiwan.
EM ywcheng2@ym.edu.tw
FU Ministry of Science and Technology [MOST 103-2401-H-010-003-MY3];
   National Yang-Ming University Hospital [RD2014-003]; Health Department
   of Taipei City Government [10301-62-009]; Ministry of Education (Aim for
   the Top University Plan)
FX The study was funded by the Ministry of Science and Technology (MOST
   103-2401-H-010-003-MY3), National Yang-Ming University Hospital
   (RD2014-003), Health Department of Taipei City Government
   (10301-62-009), and Ministry of Education (Aim for the Top University
   Plan). The funders had no role in the study design, data collection and
   analyses, decision to publish, or preparation of the manuscript.
CR Amenedo E, 2000, EUR J NEUROSCI, V12, P2570, DOI 10.1046/j.1460-9568.2000.00114.x
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Belin P, 2010, NEURON, V65, P733, DOI 10.1016/j.neuron.2010.03.018
   Belin P, 2004, TRENDS COGN SCI, V8, P129, DOI 10.1016/j.tics.2004.01.008
   Boersma P., 2001, GLOT INT, V5, P341
   Ceponiene R, 2003, P NATL ACAD SCI USA, V100, P5567
   Cheng YW, 2012, J COGNITIVE NEUROSCI, V24, P1411, DOI 10.1162/jocn_a_00214
   Dawson G, 1989, AUTISM NATURE DIAGNO
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
   Duncan CC, 2009, CLIN NEUROPHYSIOL, V120, P1883, DOI 10.1016/j.clinph.2009.07.045
   Dunn MA, 2008, J AUTISM DEV DISORD, V38, P52, DOI 10.1007/s10803-007-0359-3
   Escera C, 2000, AUDIOL NEURO-OTOL, V5, P151, DOI 10.1159/000013877
   Ethofer T, 2012, CEREB CORTEX, V22, P191, DOI 10.1093/cercor/bhr113
   Fan YT, 2013, NEUROREPORT, V24, P457, DOI 10.1097/WNR.0b013e32836169b9
   Ferri R, 2003, CLIN NEUROPHYSIOL, V114, P1671, DOI 10.1016/S1388-2457(03)00153-6
   Flom R, 2007, DEV PSYCHOL, V43, P238, DOI 10.1037/0012-1649.43.1.238
   Folstein JR, 2008, PSYCHOPHYSIOLOGY, V45, P152, DOI 10.1111/j.1469-8986.2007.00602.x
   Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291
   GIARD MH, 1990, PSYCHOPHYSIOLOGY, V27, P627, DOI 10.1111/j.1469-8986.1990.tb03184.x
   Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
   Gomot M, 2002, PSYCHOPHYSIOLOGY, V39, P577, DOI 10.1017/S0048577202394058
   Griffin R, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-61
   Grossmann T, 2012, SOC NEUROSCI-UK, V7, P369, DOI 10.1080/17470919.2011.628758
   Grossmann T, 2010, NEURON, V65, P852, DOI 10.1016/j.neuron.2010.03.001
   HOBSON RP, 1989, BRIT J DEV PSYCHOL, V7, P237
   Hung AY, 2014, NEUROREPORT, V25, P464, DOI 10.1097/WNR.0000000000000115
   Hung AY, 2013, J CHILD PSYCHOL PSYC, V54, P1016, DOI 10.1111/jcpp.12076
   Ito TA, 1998, J PERS SOC PSYCHOL, V75, P887, DOI 10.1037//0022-3514.75.4.887
   Jansson-Verkasalo E, 2003, NEUROSCI LETT, V338, P197, DOI 10.1016/S0304-3940(02)01405-2
   Jarvinen-Pasley A, 2008, DEVELOPMENTAL SCI, V11, P109, DOI 10.1111/j.1467-7687.2007.00644.x
   KEMNER C, 1995, BIOL PSYCHIAT, V38, P150, DOI 10.1016/0006-3223(94)00247-Z
   Khalfa S, 2004, HEARING RES, V198, P87, DOI 10.1016/j.heares.2004.07.006
   KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995
   Korpilahti P, 2007, J AUTISM DEV DISORD, V37, P1539, DOI 10.1007/s10803-006-0271-2
   Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x
   Kujala T, 2001, CLIN NEUROPHYSIOL, V112, P1712, DOI 10.1016/S1388-2457(01)00625-3
   Kujala T, 2005, NEUROSCI LETT, V383, P260, DOI 10.1016/j.neulet.2005.04.048
   Lepisto T, 2008, BIOL PSYCHOL, V77, P25, DOI 10.1016/j.biopsycho.2007.08.010
   Lepisto T, 2006, CLIN NEUROPHYSIOL, V117, P2161, DOI 10.1016/j.clinph.2006.06.709
   Lepisto T, 2005, BRAIN RES, V1066, P147, DOI 10.1016/j.brainres.2005.10.052
   Light GA, 2005, AM J PSYCHIAT, V162, P1741, DOI 10.1176/appi.ajp.162.9.1741
   LINCOLN AJ, 1993, J AUTISM DEV DISORD, V23, P37, DOI 10.1007/BF01066417
   Locke J. L., 1993, CHILDS PATH SPOKEN L
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
   MEHLER J, 1988, COGNITION, V29, P143, DOI 10.1016/0010-0277(88)90035-2
   Mottron L, 2011, NATURE, V479, P33, DOI 10.1038/479033a
   Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253
   Naatanen R, 2007, CLIN NEUROPHYSIOL, V118, P2544, DOI 10.1016/j.clinph.2007.04.026
   NICHOLSO.C, 1973, IEEE T BIO-MED ENG, VBM20, P278, DOI 10.1109/TBME.1973.324192
   Novitski N, 2004, COGNITIVE BRAIN RES, V20, P26, DOI 10.1016/j.cogbrainres.2003.12.011
   O'Connor K, 2012, NEUROSCI BIOBEHAV R, V36, P836, DOI 10.1016/j.neubiorev.2011.11.008
   Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
   PRATTO F, 1991, J PERS SOC PSYCHOL, V61, P380, DOI 10.1037/0022-3514.61.3.380
   Roberts TPL, 2011, BIOL PSYCHIAT, V70, P263, DOI 10.1016/j.biopsych.2011.01.015
   Rutherford MD, 2002, J AUTISM DEV DISORD, V32, P189, DOI 10.1023/A:1015497629971
   Schirmer A, 2007, BRAIN RES, V1176, P103, DOI 10.1016/j.brainres.2007.08.008
   Schirmer A, 2008, NEUROIMAGE, V40, P1402, DOI 10.1016/j.neuroimage.2008.01.018
   Seri S, 1999, CLIN NEUROPHYSIOL, V110, P1825, DOI 10.1016/S1388-2457(99)00137-6
   Stefanics G, 2012, NEUROIMAGE, V59, P3042, DOI 10.1016/j.neuroimage.2011.10.041
   Sussman E.S., 2013, BRAIN TOPOGR
   Vouloumanos A, 2007, DEVELOPMENTAL SCI, V10, P159, DOI 10.1111/j.1467-7687.2007.00549.x
   Vuilleumier P, 2005, TRENDS COGN SCI, V9, P585, DOI 10.1016/j.tics.2005.10.011
   Wechsler D., 2008, WECHSLER ADULT INTEL
   Winer BJ, 1991, STAT PRINCIPLES EXPT
NR 67
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 18
PY 2014
VL 9
IS 7
AR e102471
DI 10.1371/journal.pone.0102471
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM1OC
UT WOS:000339615200061
PM 25036143
ER

PT J
AU Michelas, A
   Faget, C
   Portes, C
   Lienhart, AS
   Boyer, L
   Lancon, C
   Champagne-Lavau, M
AF Michelas, Amandine
   Faget, Catherine
   Portes, Cristel
   Lienhart, Anne-Sophie
   Boyer, Laurent
   Lancon, Christophe
   Champagne-Lavau, Maud
TI Do patients with schizophrenia use prosody to encode contrastive
   discourse status?
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE prosodic phrasing; contrastive discourse status; theory of mind; social
   interaction; attribution of knowledge; schizophrenia; French
ID SOCIAL COGNITION; MIND DEFICITS; PEOPLE; POOR; METAANALYSIS;
   RECOGNITION; ATTRIBUTION; PERCEPTION; LANGUAGE; AUTISM
AB Patients with schizophrenia (SZ) often display social cognition disorders, including Theory of Mind (ToM) impairments and communication disruptions. Thought language disorders appear to be primarily a disruption of pragmatics, SZ can also experience difficulties at other linguistic levels including the prosodic one. Here, using an interactive paradigm, we showed that SZ individuals did not use prosodic phrasing to encode the contrastive status of discourse referents in French. We used a semi-spontaneous task to elicit noun-adjective pairs in which the noun in the second noun-adjective fragment was identical to the noun in the first fragment (e.g., BONBONS marron "brown candies" vs. BONBONS violets "purple candies") or could contrast with it (e.g., BOUGIES violettes "purple candles" vs. BONBONS violets "purple candies"). We found that healthy controls parsed the target noun in the second noun-adjective fragment separately from the color adjective, to warn their interlocutor that this noun constituted a contrastive entity (e.g., BOUGIES violettes followed by [BONBONS] [violets]) compared to when it referred to the same object as in the first fragment (e.g., BONBONS marron followed by [BONBONS violets]). On the contrary, SZ individuals did not use prosodic phrasing to encode contrastive status of target nouns. In addition, SZ's difficulties to use prosody of contrast were correlated to their score in a classical ToM task (i.e., the hinting task). Taken together, our data provide evidence that SZ patients exhibit difficulties to prosodically encode discourse statuses and sketch a potential relationship between ToM and the use of linguistic prosody.
C1 [Michelas, Amandine; Portes, Cristel; Lienhart, Anne-Sophie; Champagne-Lavau, Maud] Aix Marseille Univ, CNRS, UMR 7309, LPL, Aix En Provence, France.
   [Faget, Catherine; Boyer, Laurent; Lancon, Christophe] Aix Marseille Univ, EA Publ Hlth 3279, Chron Dis & Qual Life Res Unit, Marseille, France.
   [Faget, Catherine; Boyer, Laurent; Lancon, Christophe] St Marguerite Univ Hosp, Dept Psychiat, Marseille, France.
RP Michelas, A (reprint author), Lab Parole & Langage, 5 Ave Pasteur,BP 80975, F-13100 Aix En Provence, France.
EM michelas@lpl-aix.fr
CR ANDERSON AH, 1991, LANG SPEECH, V34, P351
   Astesano C., 2001, RYTHME ACCENTUATION
   Baayen R. H., 2010, INT J PSYCHOL RES, V3, P12
   Baayen R. H., 2008, ANAL LINGUISTIC DATA, DOI [10.1017/CBO9780511801686, DOI 10.1017/CB09780511801686]
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Barr DJ, 2013, J MEM LANG, V68, P255, DOI 10.1016/j.jml.2012.11.001
   Bates D, 2008, LME4 LINEAR MIXED EF
   Beckman M. E., 1986, PHONOLOGY YB, V3, P255, DOI 10.1017/S095267570000066X
   Beyssade C., 2009, ACTES INTERFACE DISC, P109
   Boersma P., 2009, PRAAT DOING PHONETIC
   Bora E, 2007, EUR ARCH PSY CLIN N, V257, P104, DOI 10.1007/s00406-006-0681-3
   Bora E, 2006, PSYCHIAT RES, V145, P95, DOI 10.1016/j.psychres.2005.11.003
   Brown G, 1983, TEACHING TALK
   Brune M, 2005, SCHIZOPHRENIA BULL, V31, P21, DOI 10.1093/schbul/sbi002
   Brune M, 2007, SCHIZOPHR RES, V92, P151, DOI 10.1016/J.SCHRES.2007.01.006
   Brune M, 2012, EUR PSYCHIAT, V27, P358, DOI 10.1016/j.eurpsy.2010.10.002
   Chafe W. L., 1976, SUBJECT TOPIC, P25
   Champagne-Lavau M, 2010, J NEUROLINGUIST, V23, P285, DOI 10.1016/j.jneuroling.2009.08.009
   Champagne-Lavau M, 2012, PSYCHIAT RES, V200, P184, DOI 10.1016/j.psychres.2012.06.011
   Champagne-Lavau Maud, 2009, Cogn Neuropsychiatry, V14, P217, DOI 10.1080/13546800903004114
   Chen A., 2010, P SPEECH PROS 2010 C
   Chevallier C, 2011, NEUROPSYCHOLOGIA, V49, P507, DOI 10.1016/j.neuropsychologia.2010.11.042
   Clark H. H., 1977, DISCOURSE PRODUCTION, P1
   Clark H. H., 1996, USING LANGUAGE, DOI [10.1017/CBO9780511620539, DOI 10.1017/CB09780511620539]
   CLEMMER EJ, 1980, J PSYCHOLINGUIST RES, V9, P161, DOI 10.1007/BF01067469
   CORCORAN R, 1995, SCHIZOPHR RES, V17, P5, DOI 10.1016/0920-9964(95)00024-G
   Cruttenden A., 1986, INTONATION
   Dahan D, 2002, J MEM LANG, V47, P292, DOI 10.1016/S0749-596X(02)00001-3
   D'Imperio M., 2012, PROSODY MEANING, P11, DOI [10.1515/9783110261790.11, DOI 10.1515/9783110261790.11]
   DePape AMR, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00072
   Dohen M., 2004, P INT 2004 JEJ ISL
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   Fery Caroline, 2001, AUDIATUR VOX SAPIENT, P153
   Feyereisen P, 2007, INT J LANG COMM DIS, V42, P1, DOI 10.1080/13682820600624216
   German J., 2010, P SPEECH PROS 2010 C
   Goldman J. P., 2007, EASYALIGN SEMIAUTOMA
   Green MJ, 2008, J PSYCHIATR NEUROSCI, V33, P34
   Greig TC, 2004, J NERV MENT DIS, V192, P12, DOI 10.1097/01.nmd.0000105995.67947.fc
   Halliday M. A. K., 1967, INTONATION GRAMMAR B
   Hoekert M, 2007, SCHIZOPHR RES, V96, P135, DOI 10.1016/j.schres.2007.07.023
   Ito K, 2008, J MEM LANG, V58, P541, DOI 10.1016/j.jml.2007.06.013
   Janssen I, 2003, ACTA PSYCHIAT SCAND, V108, P110, DOI 10.1034/j.1600-0447.2003.00092.x
   Jun S. A., 2002, PROBUS, V14, P147, DOI 10.1515/prbs.2002.002
   Jun S. A., 1995, P 13 INT C PHON SCI, V2, P722
   Jun SA, 2000, TEXT SPEECH LANG TEC, V15, P209
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261
   Kern RS, 2009, PSYCHOL MED, V39, P645, DOI 10.1017/S0033291708003966
   Kosmidis MH, 2008, BEHAV NEUROL, V19, P65
   Langdon Robyn, 2006, Cogn Neuropsychiatry, V11, P133, DOI 10.1080/13546800444000218
   Leitman DI, 2006, PSYCHOL MED, V36, P1075, DOI 10.1017/S0033291706007653
   Mazza M, 2001, SCHIZOPHR RES, V47, P299, DOI 10.1016/S0920-9964(00)00157-2
   McCabe R, 2004, PSYCHOL MED, V34, P401, DOI 10.1017/S0033291703001338
   McCann J, 2003, INT J LANG COMM DIS, V38, P325, DOI 10.1080/1368282031000154204
   Michelas A, 2012, J PHONETICS, V40, P816, DOI 10.1016/j.wocn.2012.08.004
   Pasdeloup V., 1990, THESIS AIX MARSEILLE
   Pickering MJ, 2004, BEHAV BRAIN SCI, V27, P169
   Pierrehumbert J., 1990, INTENTIONS COMMUNICA, P342
   Pierrehumbert Janet, 1980, THESIS MIT CAMBRIDGE
   Premack D., 1978, BEHAVIORAL BRAIN SCI, V4, P515, DOI [10.1017/S0140525X00076512, DOI 10.1017/S0140525X00076512]
   Prince E. F., 1986, PAPERS PARASESSION P, P208
   R Development Core Team, 2008, R LANG ENV STAT COMP
   RIEBER RW, 1994, J PSYCHOLINGUIST RES, V23, P149, DOI 10.1007/BF02143921
   Selkirk E. O., 1984, PHONOLOGY SYNTAX REL
   Sparks A, 2010, SCHIZOPHR RES, V122, P172, DOI 10.1016/j.schres.2010.06.011
   Sprong M, 2007, BRIT J PSYCHIAT, V191, P5, DOI 10.1192/bjp.bp.107.035899
   Welby P, 2006, J PHONETICS, V34, P343, DOI 10.1016/j.wocn.2005.09.001
NR 66
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUL 18
PY 2014
VL 5
AR 755
DI 10.3389/fpsyg.2014.00755
PG 13
WC Psychology, Multidisciplinary
SC Psychology
GA AL4QY
UT WOS:000339118800001
PM 25101025
ER

PT J
AU Bernier, R
   Golzio, C
   Xiong, B
   Stessman, HA
   Coe, BP
   Penn, O
   Witherspoon, K
   Gerdts, J
   Baker, C
   Vulto-van Silfhout, AT
   Schuurs-Hoeijmakers, JH
   Fichera, M
   Bosco, P
   Buono, S
   Alberti, A
   Failla, P
   Peeters, H
   Steyaert, J
   Vissers, LELM
   Francescatto, L
   Mefford, HC
   Rosenfeld, JA
   Bakken, T
   O'Roak, BJ
   Pawlus, M
   Moon, R
   Shendure, J
   Amaral, DG
   Lein, E
   Rankin, J
   Romano, C
   de Vries, BBA
   Katsanis, N
   Eichler, EE
AF Bernier, Raphael
   Golzio, Christelle
   Xiong, Bo
   Stessman, Holly A.
   Coe, Bradley P.
   Penn, Osnat
   Witherspoon, Kali
   Gerdts, Jennifer
   Baker, Carl
   Vulto-van Silfhout, Anneke T.
   Schuurs-Hoeijmakers, Janneke H.
   Fichera, Marco
   Bosco, Paolo
   Buono, Serafino
   Alberti, Antonino
   Failla, Pinella
   Peeters, Hilde
   Steyaert, Jean
   Vissers, Lisenka E. L. M.
   Francescatto, Ludmila
   Mefford, Heather C.
   Rosenfeld, Jill A.
   Bakken, Trygve
   O'Roak, Brian J.
   Pawlus, Matthew
   Moon, Randall
   Shendure, Jay
   Amaral, David G.
   Lein, Ed
   Rankin, Julia
   Romano, Corrado
   de Vries, Bert B. A.
   Katsanis, Nicholas
   Eichler, Evan E.
TI Disruptive CHD8 Mutations Define a Subtype of Autism Early in
   Development
SO CELL
LA English
DT Article
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; CHARGE-SYNDROME; HEART-DISEASE;
   GENE; ZEBRAFISH; ABNORMALITIES; ASSOCIATION; EXPRESSION; CHILDREN
AB Autism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define subtypes behaviorally have met with limited success. Hypothesizing that genetically based subtype identification may prove more productive, we resequenced the ASD-associated gene CHD8 in 3,730 children with developmental delay or ASD. We identified a total of 15 independent mutations; no truncating events were identified in 8,792 controls, including 2,289 unaffected siblings. In addition to a high likelihood of an ASD diagnosis among patients bearing CHD8 mutations, characteristics enriched in this group included macrocephaly, distinct faces, and gastrointestinal complaints. chd8 disruption in zebrafish recapitulates features of the human phenotype, including increased head size as a result of expansion of the forebrain/midbrain and impairment of gastrointestinal motility due to a reduction in postmitotic enteric neurons. Our findings indicate that CHD8 disruptions define a distinct ASD subtype and reveal unexpected comorbidities between brain development and enteric innervation.
C1 [Bernier, Raphael; Gerdts, Jennifer] Univ Washington, Dept Psychiat, Seattle, WA 98195 USA.
   [Golzio, Christelle; Francescatto, Ludmila; Katsanis, Nicholas] Duke Univ, Med Ctr, Ctr Human Dis Modeling, Durham, NC 27710 USA.
   [Xiong, Bo; Coe, Bradley P.; Penn, Osnat; Witherspoon, Kali; Baker, Carl; Shendure, Jay; Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA.
   [Vulto-van Silfhout, Anneke T.; Schuurs-Hoeijmakers, Janneke H.; de Vries, Bert B. A.] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 GA Nijmegen, Netherlands.
   [Fichera, Marco; Bosco, Paolo; Buono, Serafino; Alberti, Antonino; Failla, Pinella; Romano, Corrado] IRCCS Associaz Oasi Maria Santissima, I-94018 Troina, Italy.
   [Fichera, Marco] Univ Catania, I-95123 Catania, Italy.
   [Peeters, Hilde] Katholieke Univ Leuven, Univ Hosp Leuven, Ctr Human Genet, B-3000 Leuven, Belgium.
   [Peeters, Hilde; Steyaert, Jean] Leuven Autism Res LAuRes, B-3000 Leuven, Belgium.
   [Steyaert, Jean] Katholieke Univ Leuven, Dept Child & Adolescent Psychiat, B-3000 Leuven, Belgium.
   [Steyaert, Jean] Maastricht Univ, Acad Hosp Maastricht, Dept Clin Genet, NL-6200 MD Maastricht, Netherlands.
   [Steyaert, Jean] Maastricht Univ, Res Inst Growth & Dev GROW, NL-6200 MD Maastricht, Netherlands.
   [Mefford, Heather C.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA.
   [Rosenfeld, Jill A.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
   [Bakken, Trygve] Allen Inst Brain Sci, Seattle, WA 98103 USA.
   [O'Roak, Brian J.] OHSU, Portland, OR 97208 USA.
   [Pawlus, Matthew; Moon, Randall] Univ Washington, Dept Pharmacol, Seattle, WA 98109 USA.
   [Amaral, David G.] Univ Calif Davis, MIND Inst, Autism Phenome Project, Sacramento, CA 95817 USA.
   [Rankin, Julia] Peninsula Clin Genet Serv, Exeter EX1 2ED, Devon, England.
   [Eichler, Evan E.] Howard Hughes Med Inst, Seattle, WA 98195 USA.
RP Eichler, EE (reprint author), Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA.
EM eee@gs.washington.edu
RI Romano, Corrado/B-9695-2008; Xiong, Bo/M-3605-2014; Vissers,
   Lisenka/A-2598-2015
OI Romano, Corrado/0000-0003-1049-0683; 
FU Simons Foundation Autism Research Initiative (SFARI) [303241]; NIH/NIMH
   [R01MH101221]; SFARI [239983]; NIH [P50MH094268]; NARSAD Young
   Investigator Grant from BBRF; European Commission; GENCODYS [241995];
   Dutch Organisation for Health Research and Development (ZON-MW)
   [917-86-319, 912-12-109]
FX This work was supported by the Simons Foundation Autism Research
   Initiative (SFARI) 303241 and NIH/NIMH R01MH101221 to E.E.E.; by SFARI
   239983 and NIH P50MH094268 to N.K.; by a NARSAD Young Investigator Grant
   from BBRF to C.G.; and by the European Commission: GENCODYS grant 241995
   under FP7 and the Dutch Organisation for Health Research and Development
   (ZON-MW grants 917-86-319 and 912-12-109) to B.B.A.d.V. E.E.E. is an
   Investigator of the Howard Hughes Medical Institute and is on the
   scientific advisory board for DNAnexus, Inc. N.K. is a Distinguished
   Brumley Professor. We thank all of the families at the participating
   Simons Simplex Collection (SSC) sites, as well as the principal
   investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E.
   Fombonne, D. Geschwind, E. Hanson, D. Grice, A. Klin, R. Kochel, D.
   Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley,
   K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J.
   Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman). We are grateful to D.
   Raible and H. S. Zimmermann for providing zebrafish resources and for
   helpful discussions, to T. Brown for help with manuscript preparation,
   and to J. Huddleston and M. Malig for sequencing support.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Batsukh T, 2010, HUM MOL GENET, V19, P2858, DOI 10.1093/hmg/ddq189
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
   Chaste P, 2013, BIOL PSYCHIAT, V74, P576, DOI 10.1016/j.biopsych.2013.04.018
   CIMENT G, 1983, NATURE, V305, P424, DOI 10.1038/305424a0
   Cocchiaro J.L., 2013, JOVE-J VIS EXP, V72, pe4434
   D'Autreaux F, 2007, DEVELOPMENT, V134, P2237, DOI 10.1242/dev.003814
   Field HA, 2009, NEUROGASTROENT MOTIL, V21, P304, DOI 10.1111/j.1365-2982.2008.01234.x
   Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
   Hennekam RCM, 2012, HUM MUTAT, V33, P884, DOI 10.1002/humu.22048
   HITTNER HM, 1979, J PEDIAT OPHTH STRAB, V16, P122
   Houdayer C, 2011, METHODS MOL BIOL, V760, P269, DOI 10.1007/978-1-61779-176-5_17
   Hwang WY, 2013, NAT BIOTECHNOL, V31, P227, DOI 10.1038/nbt.2501
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jao LE, 2013, P NATL ACAD SCI USA, V110, P13904, DOI 10.1073/pnas.1308335110
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   Kim MS, 2011, HISTOPATHOLOGY, V58, P660, DOI 10.1111/j.1365-2559.2011.03819.x
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nishiyama M, 2012, MOL CELL BIOL, V32, P501, DOI 10.1128/MCB.06409-11
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   PAGON RA, 1981, J PEDIATR-US, V99, P223, DOI 10.1016/S0022-3476(81)80454-4
   Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sawada G, 2013, ONCOL REP, V30, P1137, DOI 10.3892/or.2013.2597
   Schulze TG, 2004, HUM HERED, V58, P131, DOI 10.1159/000083539
   Shen EH, 2012, TRENDS NEUROSCI, V35, P711, DOI 10.1016/j.tins.2012.09.005
   Simon JM, 2014, GENOME RES, V24, P241, DOI 10.1101/gr.158253.113
   Simons VIP Consortium, 2012, NEURON, V73, P1063
   Stessman HA, 2014, CELL, V156, P872, DOI 10.1016/j.cell.2014.02.002
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   THISSE C, 1993, DEVELOPMENT, V119, P1203
   Thompson BA, 2008, MOL CELL BIOL, V28, P3894, DOI 10.1128/MCB.00322-08
   Vissers LELM, 2004, NAT GENET, V36, P955, DOI 10.1038/ng1407
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Westerfield M., 1995, ZEBR BOOK GUID LAB U
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
NR 43
TC 21
Z9 21
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD JUL 17
PY 2014
VL 158
IS 2
BP 263
EP 276
DI 10.1016/j.cell.2014.06.017
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AN9QU
UT WOS:000340943600008
PM 24998929
ER

PT J
AU Gilissen, C
   Hehir-Kwa, JY
   Thung, DT
   van de Vorst, M
   van Bon, BWM
   Willemsen, MH
   Kwint, M
   Janssen, IM
   Hoischen, A
   Schenck, A
   Leach, R
   Klein, R
   Tearle, R
   Bo, T
   Pfundt, R
   Yntema, HG
   de Vries, BBA
   Kleefstra, T
   Brunner, HG
   Vissers, LELM
   Veltman, JA
AF Gilissen, Christian
   Hehir-Kwa, Jayne Y.
   Thung, Djie Tjwan
   van de Vorst, Maartje
   van Bon, Bregje W. M.
   Willemsen, Marjolein H.
   Kwint, Michael
   Janssen, Irene M.
   Hoischen, Alexander
   Schenck, Annette
   Leach, Richard
   Klein, Robert
   Tearle, Rick
   Bo, Tan
   Pfundt, Rolph
   Yntema, Helger G.
   de Vries, Bert B. A.
   Kleefstra, Tjitske
   Brunner, Han G.
   Vissers, Lisenka E. L. M.
   Veltman, Joris A.
TI Genome sequencing identifies major causes of severe intellectual
   disability
SO NATURE
LA English
DT Article
ID DE-NOVO MUTATIONS; COPY-NUMBER VARIATION; MENTAL-RETARDATION; AUTISM;
   SCHIZOPHRENIA; VARIANTS; SPECTRUM; PROTEIN; PARADIGM; NETWORK
AB Severe intellectual disability (ID) occurs in 0.5% of newborns and is thought to be largely genetic in origin(1,2). The extensive genetic heterogeneity of this disorder requires a genome-wide detection of all types of genetic variation. Microarray studies and, more recently, exome sequencing have demonstrated the importance of de novo copy number variations (CNVs) and single-nucleotide variations (SNVs) in ID, but the majority of cases remain undiagnosed(3-6). Here we applied whole-genome sequencing to 50 patients with severe ID and their unaffected parents. All patients included had not received a molecular diagnosis after extensive genetic prescreening, including microarray-based CNV studies and exome sequencing. Notwithstanding this prescreening, 84 de novo SNVs affecting the coding region were identified, which showed a statistically significant enrichment of loss-of-function mutations as well as an enrichment for genes previously implicated in ID-related disorders. In addition, we identified eight de novo CNVs, including single-exon and intra-exonic deletions, as well as interchromosomal duplications. These CNVs affected known ID genes more frequently than expected. On the basis of diagnostic interpretation of all de novo variants, a conclusive genetic diagnosis was reached in 20 patients. Together with one compound heterozygous CNV causing disease in a recessive mode, this results in a diagnostic yield of 42% in this extensively studied cohort, and 62% as a cumulative estimate in an unselected cohort. These results suggest that de novo SNVs and CNVs affecting the coding region are a major cause of severe ID. Genome sequencing can be applied as a single genetic test to reliably identify and characterize the comprehensive spectrum of genetic variation, providing a genetic diagnosis in the majority of patients with severe ID.
C1 [Gilissen, Christian; Hehir-Kwa, Jayne Y.; Thung, Djie Tjwan; van de Vorst, Maartje; van Bon, Bregje W. M.; Willemsen, Marjolein H.; Kwint, Michael; Janssen, Irene M.; Hoischen, Alexander; Schenck, Annette; Bo, Tan; Pfundt, Rolph; Yntema, Helger G.; de Vries, Bert B. A.; Kleefstra, Tjitske; Brunner, Han G.; Vissers, Lisenka E. L. M.; Veltman, Joris A.] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Human Genet, NL-6525 GA Nijmegen, Netherlands.
   [Gilissen, Christian; Hehir-Kwa, Jayne Y.; Thung, Djie Tjwan; van de Vorst, Maartje; van Bon, Bregje W. M.; Willemsen, Marjolein H.; Kwint, Michael; Janssen, Irene M.; Hoischen, Alexander; Schenck, Annette; Bo, Tan; Pfundt, Rolph; Yntema, Helger G.; de Vries, Bert B. A.; Kleefstra, Tjitske; Brunner, Han G.; Vissers, Lisenka E. L. M.; Veltman, Joris A.] Radboud Univ Nijmegen, Med Ctr, Donders Ctr Neurosci, NL-6525 GA Nijmegen, Netherlands.
   [Leach, Richard; Klein, Robert; Tearle, Rick] Complete Genom Inc, Mountain View, CA 94043 USA.
   [Bo, Tan] Cent S Univ, State Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China.
   [Gilissen, Christian; Brunner, Han G.; Veltman, Joris A.] Maastricht Univ, Med Ctr, Dept Clin Genet, NL-6229 ER Maastricht, Netherlands.
RP Veltman, JA (reprint author), Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Human Genet, Geert Grootepl 10, NL-6525 GA Nijmegen, Netherlands.
EM joris.veltman@radboudumc.nl
RI Kleefstra, Tjitske/G-2619-2012; Brunner, Han/C-9928-2013; Vissers,
   Lisenka/A-2598-2015; Veltman, Joris/F-5128-2010
FU Netherlands Organization for Scientific Research [912-12-109,
   916-14-043, 916-12-095, 907-00-365, SH-271-13]; European Research
   Council (ERC) [DENOVO 281964]
FX We thank R. Drmanac, K. Albers, J. Goeman, D. Lugtenberg and P. N.
   Robinson for useful discussions, and M. Steehouwer, P. de Vries and W.
   Nillesen for technical support. This work was in part financially
   supported by grants from the Netherlands Organization for Scientific
   Research (912-12-109 to J. A. V., A. S. and B.B.A.d.V., 916-14-043 to C.
   G., 916-12-095 to A. H., 907-00-365 to T. K. and SH-271-13 to C. G. and
   J. A. V.) and the European Research Council (ERC Starting grant DENOVO
   281964 to J.A.V.).
CR Allen AS, 2013, NATURE, V501, P217, DOI 10.1038/nature12439
   Bell J, 2007, PRACTICE GUIDELINES
   Berg JS, 2011, GENET MED, V13, P499, DOI 10.1097/GIM.0b013e318220aaba
   Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
   Biesecker LG, 2013, NAT REV GENET, V14, P307, DOI 10.1038/nrg3424
   Carnevali P, 2012, J COMPUT BIOL, V19, P279, DOI 10.1089/cmb.2011.0201
   de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
   de Vries BBA, 2005, AM J HUM GENET, V77, P606, DOI 10.1086/491719
   Drmanac R, 2010, SCIENCE, V327, P78, DOI 10.1126/science.1181498
   Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
   Gulsuner S, 2013, CELL, V154, P518, DOI 10.1016/j.cell.2013.06.049
   Hehir-Kwa JY, 2013, CLIN GENET, V84, P415, DOI 10.1111/cge.12242
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   Kolehmainen J, 2003, AM J HUM GENET, V72, P1359, DOI 10.1086/375454
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Lupski JR, 2010, NEW ENGL J MED, V362, P1181, DOI 10.1056/NEJMoa0908094
   MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Petrovski S, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003709
   Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
   Rippey C, 2013, AM J HUM GENET, V93, P697, DOI 10.1016/j.ajhg.2013.09.004
   Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
   Vulto-van Silfhout AT, 2013, HUM MUTAT, V34, P1679, DOI 10.1002/humu.22442
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
NR 30
TC 35
Z9 36
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD JUL 17
PY 2014
VL 511
IS 7509
BP 344
EP +
DI 10.1038/nature13394
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AL2YR
UT WOS:000338992200035
PM 24896178
ER

PT J
AU Baron-Cohen, S
   Cassidy, S
   Auyeung, B
   Allison, C
   Achoukhi, M
   Robertson, S
   Pohl, A
   Lai, MC
AF Baron-Cohen, Simon
   Cassidy, Sarah
   Auyeung, Bonnie
   Allison, Carrie
   Achoukhi, Maryam
   Robertson, Sarah
   Pohl, Alexa
   Lai, Meng-Chuan
TI Attenuation of Typical Sex Differences in 800 Adults with Autism vs.
   3,900 Controls
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; SPECTRUM QUOTIENT AQ; SYSTEMATIZING QUOTIENT;
   ASPERGER-SYNDROME; CHILDHOOD AUTISM; EMPATHY QUOTIENT; DISORDERS;
   GENDER; FEMALES; BRAIN
AB Sex differences have been reported in autistic traits and systemizing (male advantage), and empathizing (female advantage) among typically developing individuals. In individuals with autism, these cognitive-behavioural profiles correspond to predictions from the "extreme male brain" (EMB) theory of autism (extreme scores on autistic traits and systemizing, below average on empathizing). Sex differences within autism, however, have been under-investigated. Here we show in 811 adults (454 females) with autism and 3,906 age-matched typical control adults (2,562 females) who completed the Empathy Quotient (EQ), the Systemizing Quotient-Revised (SQ-R), and the Autism Spectrum Quotient (AQ), that typical females on average scored higher on the EQ, typical males scored higher on the SQ-R and AQ, and both males and females with autism showed a shift toward the extreme of the "male profile" on these measures and in the distribution of "brain types" (the discrepancy between standardized EQ and SQ-R scores). Further, normative sex differences are attenuated but not abolished in adults with autism. The findings provide strong support for the EMB theory of autism, and highlight differences between males and females with autism.
C1 [Baron-Cohen, Simon; Cassidy, Sarah; Auyeung, Bonnie; Allison, Carrie; Achoukhi, Maryam; Robertson, Sarah; Pohl, Alexa; Lai, Meng-Chuan] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Baron-Cohen, Simon; Lai, Meng-Chuan] Cambridgeshire & Peterborough Natl Hlth Serv Fdn, Cambridge Lifespan Asperger Syndrome Serv CLASS C, Cambridge, England.
   [Auyeung, Bonnie] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland.
   [Lai, Meng-Chuan] Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, Taipei, Taiwan.
RP Baron-Cohen, S (reprint author), Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
EM sb205@cam.ac.uk; mcl45@cam.ac.uk
FU UK Medical Research Council; Wellcome Trust; Autism Research Trust;
   William Binks Autism Neuroscience Fellowship; European Autism
   Interventions - A Multicentre Study for Developing New Medications
   (EU-AIMS); Wolfson College, Cambridge
FX This study received funding from the UK Medical Research Council, the
   Wellcome Trust, and the Autism Research Trust. Meng-Chuan Lai was
   supported by the William Binks Autism Neuroscience Fellowship, the
   European Autism Interventions - A Multicentre Study for Developing New
   Medications (EU-AIMS), and Wolfson College, Cambridge. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Allison C, 2008, J AUTISM DEV DISORD, V38, P1414, DOI 10.1007/s10803-007-0509-7
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731
   Auyeung B, 2009, J AUTISM DEV DISORD, V39, P1509, DOI 10.1007/s10803-009-0772-x
   Baron Cohen S, 2014, MOL PSYCHIATR, DOI [10.1038/mp.2014.48, DOI 10.1038/MP.2014.48]
   Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
   Beacher FD, 2012, AM J NEURORADIOL, V33, P83, DOI 10.3174/ajnr.A2880
   Beacher FDCC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038355
   Begeer S, 2013, J AUTISM DEV DISORD, V43, P1151, DOI 10.1007/s10803-012-1656-z
   Bejerot S, 2012, BRIT J PSYCHIAT, V201, P116, DOI 10.1192/bjp.bp.111.097899
   Bejerot S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087961
   Bolte S, 2011, AUTISM, V15, P497, DOI 10.1177/1362361310391116
   Carter AS, 2007, J AUTISM DEV DISORD, V37, P86, DOI 10.1007/s10803-006-0331-7
   Constantino JN, 2012, J AM ACAD CHILD PSY, V51, P756, DOI 10.1016/j.jaac.2012.05.017
   Daniels AM, 2011, J AUTISM DEV DISORD, V41, P110, DOI 10.1007/s10803-010-1031-x
   Dworzynski K, 2012, J AM ACAD CHILD PSY, V51, P788, DOI 10.1016/j.jaac.2012.05.018
   Field A, 2013, DISCOVERING STAT USI
   Frazier TW, 2014, J AM ACAD CHILD PSY, V53, P329, DOI 10.1016/j.jaac.2013.12.004
   Goldenfeld N, 2005, CLIN NEUROPSYCHIATRY, V2, P8
   Gould J., 2011, GOOD AUTISM PRACTICE, V12, P34
   Grantham CL, 2011, INT M AUT RES SAN DI
   Hinkka-Yli-Salomaki S, 2014, NORD J PSYCHIAT, V68, P472, DOI 10.3109/08039488.2013.861017
   Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361
   Idring S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041280
   Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
   Jensen CM, 2014, J AUTISM DEV DISORD, V44, P1808, DOI 10.1007/s10803-014-2053-6
   Kirkovski M, 2013, J AUTISM DEV DISORD, V43, P2584, DOI 10.1007/s10803-013-1811-1
   Knickmeyer RC, 2008, J AUTISM DEV DISORD, V38, P1028, DOI 10.1007/s10803-007-0475-0
   Kreiser NL, 2014, CLIN CHILD FAM PSYCH, V17, P67, DOI 10.1007/s10567-013-0148-9
   Lai MC, 2014, LANCET, V383, P896, DOI 10.1016/S0140-6736(13)61539-1
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   Lai MC, 2013, BRAIN, V136, P2799, DOI 10.1093/brain/awt216
   Lai MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047198
   Lai MC, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001544
   Lemler M, 2012, DISCUSSIONS, V8, P2
   Lemon JM, 2011, J AUTISM DEV DISORD, V41, P352, DOI 10.1007/s10803-010-1039-2
   Mandy W, 2012, J AUTISM DEV DISORD, V42, P1304, DOI 10.1007/s10803-011-1356-0
   Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
   MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216
   Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466
   Pohl A, 2014, MOL AUTISM, V5, DOI 10.1186/2040-2392-5-27
   Ruta L, 2011, PSYCHONEUROENDOCRINO, V36, P1154, DOI 10.1016/j.psyneuen.2011.02.007
   Saemundsen E, 2013, BMJ OPEN, V3
   Sarachana T, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-14
   Schaafsma SM, 2014, FRONT NEUROENDOCRIN, V35, P255, DOI 10.1016/j.yfrne.2014.03.006
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238
   Van Wijngaarden-Cremers PJM, 2014, J AUTISM DEV DISORD, V44, P627, DOI 10.1007/s10803-013-1913-9
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
   Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
   WING L, 1981, PSYCHIAT RES, V5, P129, DOI 10.1016/0165-1781(81)90043-3
NR 58
TC 4
Z9 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 16
PY 2014
VL 9
IS 7
AR e102251
DI 10.1371/journal.pone.0102251
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO4KM
UT WOS:000341306600051
PM 25029203
ER

PT J
AU Gebauer, L
   Skewes, J
   Westphael, G
   Heaton, P
   Vuust, P
AF Gebauer, Line
   Skewes, Joshua
   Westphael, Gitte
   Heaton, Pamela
   Vuust, Peter
TI Intact brain processing of musical emotions in autism spectrum disorder,
   but more cognitive load and arousal in happy vs. sad music
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorder; music; emotion; fMRI
ID SUPERIOR TEMPORAL SULCUS; ASPERGERS-SYNDROME; FACIAL EXPRESSIONS;
   PERCEPTION; RESPONSES; CHILDREN; FACE; ALEXITHYMIA; RECOGNITION;
   EXPERIENCE
AB Music is a potent source for eliciting emotions, but not everybody experience emotions in the same way. Individuals with autism spectrum disorder (ASD) show difficulties with social and emotional cognition. Impairments in emotion recognition are widely studied in ASD, and have been associated with atypical brain activation in response to emotional expressions in faces and speech. Whether these impairments and atypical brain responses generalize to other domains, such as emotional processing of music, is less clear. Using functional magnetic resonance imaging, we investigated neural correlates of emotion recognition in music in high-functioning adults with ASD and neurotypical adults. Both groups engaged similar neural networks during processing of emotional music, and individuals with ASD rated emotional music comparable to the group of neurotypical individuals. However, in the ASD group, increased activity in response to happy compared to sad music was observed in dorsolateral prefrontal regions and in the rolandic operculum/insula, and we propose that this reflects increased cognitive processing and physiological arousal in response to emotional musical stimuli in this group.
C1 [Gebauer, Line; Skewes, Joshua; Westphael, Gitte; Vuust, Peter] Aarhus Univ, Ctr Functionally Integrat Neurosci, Dept Clin Med, DK-8000 Aarhus, Denmark.
   [Gebauer, Line] Aarhus Univ, Interacting Minds Ctr, DK-8000 Aarhus, Denmark.
   [Heaton, Pamela] Goldsmiths Univ London, Dept Psychol, London, England.
   [Vuust, Peter] Royal Acad Mus, Aarhus, Denmark.
RP Gebauer, L (reprint author), Aarhus Univ, Ctr Functionally Integrat Neurosci, Dept Clin Med, Noerrebrogade 44,Build 10G,5th Floor, DK-8000 Aarhus, Denmark.
EM gebauer@pet.auh.dk
FU Lundbeck Foundation [R32-A2846]
FX This work was supported by the Lundbeck Foundation (R32-A2846 to Line
   Gebauer).
CR Adolphs R, 2002, CURR OPIN NEUROBIOL, V12, P169, DOI 10.1016/S0959-4388(02)00301-X
   Ahsan RL, 2007, NEUROIMAGE, V38, P261, DOI 10.1016/j.neuroimage.2007.06.004
   Allen R, 2009, AUTISM, V13, P21, DOI 10.1177/1362361307098511
   Allen R, 2009, ANN NY ACAD SCI, V1169, P326, DOI 10.1111/j.1749-6632.2009.04772.x
   Allen R, 2013, J AUTISM DEV DISORD, V43, P432, DOI 10.1007/s10803-012-1587-8
   American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
   Anderson JS, 2010, AM J NEURORADIOL, V31, P131, DOI 10.3174/ajnr.A1789
   Ashburner J, 1999, HUM BRAIN MAPP, V7, P254, DOI 10.1002/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G
   Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Berlyne D. E., 1971, AESTHETICS PSYCHOBIO
   Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
   Blood AJ, 1999, NAT NEUROSCI, V2, P382, DOI 10.1038/7299
   Blood AJ, 2001, P NATL ACAD SCI USA, V98, P11818, DOI 10.1073/pnas.191355898
   Boisgueheneuc F, 2006, BRAIN, V129, P3315, DOI 10.1093/brain/awl244
   Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   Brattico E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00308
   Brown S, 2004, NEUROREPORT, V15, P2033, DOI 10.1097/00001756-200409150-00008
   Caria A, 2011, CEREB CORTEX, V21, P2838, DOI 10.1093/cercor/bhr084
   Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
   Bird G, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.61
   Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
   Craig AD, 2002, NAT REV NEUROSCI, V3, P655, DOI 10.1038/nrn894
   Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
   Critchley HD, 2005, J COMP NEUROL, V493, P154, DOI 10.1002/cne.20749
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Dube L, 2003, COGNITION EMOTION, V17, P263, DOI 10.1080/02699930244000309
   Eigsti IM, 2012, CHILD NEUROPSYCHOL, V18, P600, DOI 10.1080/09297049.2011.639757
   Etkin A, 2011, TRENDS COGN SCI, V15, P85, DOI 10.1016/j.tics.2010.11.004
   Eyler LT, 2012, BRAIN, V135, P949, DOI 10.1093/brain/awr364
   Fitch WT, 2005, ANN NY ACAD SCI, V1060, P29, DOI 10.1196/annals.1360.004
   Fitzgerald M, 2006, J AUTISM DEV DISORD, V36, P573, DOI 10.1007/s10803-006-0096-z
   Friston KJ, 1994, HUMAN BRAIN MAPPING, V2, P189, DOI DOI 10.1002/HBM.460020402
   Friston KJ, 1996, NEUROIMAGE, V4, P223, DOI 10.1006/nimg.1996.0074
   Gabrielsson A., 2002, MUSIC SCI, V5, P123, DOI [10.1177/10298649020050S105, DOI 10.1177/10298649020050S105]
   Gasquoine PG, 2014, NEUROPSYCHOL REV, V24, P77, DOI 10.1007/s11065-014-9246-9
   Gebauer L., 2012, PSYCHOMUSICOLOGY, V22, P152, DOI [10.1037/a0031126, DOI 10.1037/A0031126]
   Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291
   Gillberg C, 1996, DEV MED CHILD NEUROL, V38, P191
   Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
   Grewe O, 2005, ANN NY ACAD SCI, V1060, P446, DOI 10.1196/annals.1360.041
   Griffiths TD, 2004, J NEUROL NEUROSUR PS, V75, P344
   Hadjikhani N, 2009, SOC COGN AFFECT NEUR, V4, P70, DOI 10.1093/scan/nsn038
   Heaton P, 2012, PSYCHOL MED, V42, P2453, DOI 10.1017/S0033291712000621
   Heaton P, 1999, NEUROCASE, V5, P503, DOI 10.1080/13554799908402745
   Heaton P, 2005, J AUTISM DEV DISORD, V35, P787, DOI 10.1007/s10803-005-0024-7
   Heaton P, 2003, J CHILD PSYCHOL PSYC, V44, P543, DOI 10.1111/1469-7610.00143
   Heaton P, 2008, BRIT J DEV PSYCHOL, V26, P171, DOI 10.1348/026151007X206776
   Hobson P., 2005, HDB AUTISM PERVASIVE, V1, P406
   HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
   Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
   Huron D, 2001, ANN NY ACAD SCI, V930, P43
   Huron D., 2006, SWEET ANTICIPATION M
   Janata P, 2003, NAT NEUROSCI, V6, P682, DOI 10.1038/nn1081
   Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
   Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
   Juslin P. N., 2008, BEHAV BRAIN SCI, V31, P575, DOI [DOI 10.1017/50140525X08005293, 10.1017/50140525X08005293]
   Juslin PN, 2008, BEHAV BRAIN SCI, V31, P559, DOI 10.1017/S0140525X08005293
   Juslin PN, 2004, J NEW MUSIC RES, V33, P217, DOI 10.1080/0929821042000317813
   Kanner L, 1943, NERV CHILD, V2, P217
   Koelsch S, 2008, NEUROREPORT, V19, P1815, DOI 10.1097/WNR.0b013e32831a8722
   Koelsch S, 2013, NEUROIMAGE, V81, P49, DOI 10.1016/j.neuroimage.2013.05.008
   Koelsch S, 2006, HUM BRAIN MAPP, V27, P239, DOI 10.1002/hbm.20180
   Koelsch S, 2010, TRENDS COGN SCI, V14, P131, DOI 10.1016/j.tics.2010.01.002
   Kohls G, 2013, SOC COGN AFFECT NEUR, V8, P565, DOI 10.1093/scan/nss033
   Koneni V. J., 2008, PSYCHOL AESTHET CREA, V2, P115, DOI DOI 10.1037/1931-3896.2.2.115
   Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
   Levitin Daniel, 2006, THIS IS YOUR BRAIN M
   Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Maldjian JA, 2003, NEUROIMAGE, V19, P1233, DOI 10.1016/S1053-8119(03)00169-1
   Mazefsky CA, 2007, J AUTISM DEV DISORD, V37, P1086, DOI 10.1007/s10803-006-0251-6
   Menon V, 2010, BRAIN STRUCT FUNCT, V214, P655, DOI 10.1007/s00429-010-0262-0
   Menon V, 2005, NEUROIMAGE, V28, P175, DOI 10.1016/j.neuroimage.2005.05.053
   Mitterschiffthaler MT, 2007, HUM BRAIN MAPP, V28, P1150, DOI 10.1002/hbm.20337
   Moesgaard K., 2010, MUSIC BRANDING PLAT
   Mueller K, 2011, NEUROIMAGE, V54, P337, DOI 10.1016/j.neuroimage.2010.08.029
   NORTH AC, 1995, PSYCHOMUSICOLOGY, V14, P77, DOI DOI 10.1037/H0094090
   Nuske HJ, 2013, COGNITION EMOTION, V27, P1042, DOI 10.1080/02699931.2012.762900
   Overy K, 2012, ANN NY ACAD SCI, V1252, P65, DOI 10.1111/j.1749-6632.2012.06530.x
   Park M, 2013, BRAIN RES, V1523, P68, DOI 10.1016/j.brainres.2013.05.042
   Penny W.D., 2011, STAT PARAMETRIC MAPP
   Pereira CS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027241
   Peretz I., 2010, HDB MUSIC EMOTION TH, P99
   Perrachione TK, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00055
   Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
   Quintin EM, 2011, J AUTISM DEV DISORD, V41, P1240, DOI 10.1007/s10803-010-1146-0
   Redcay E, 2008, NEUROSCI BIOBEHAV R, V32, P123, DOI 10.1016/j.neubiorev.2007.06.004
   Rentfrow PJ, 2003, J PERS SOC PSYCHOL, V84, P1236, DOI 10.1037/0022-3514.84.6.1236
   Salimpoor VN, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007487
   Salimpoor VN, 2013, SCIENCE, V340, P216, DOI 10.1126/science.1231059
   Salimpoor VN, 2011, NAT NEUROSCI, V14, P257, DOI 10.1038/nn.2726
   Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
   Stanutz S, 2014, AUTISM, V18, P137, DOI 10.1177/1362361312462905
   Trost W, 2012, CEREB CORTEX, V22, P2769, DOI 10.1093/cercor/bhr353
   Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
   van den Bosch I, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00534
   Wallentin M, 2010, LEARN INDIVID DIFFER, V20, P188, DOI 10.1016/j.lindif.2010.02.004
   Wang AT, 2006, BRAIN, V129, P932, DOI 10.1093/brain/awl032
   Wang AT, 2007, ARCH GEN PSYCHIAT, V64, P698, DOI 10.1001/archpsyc.64.6.698
   Wechsler D., 1997, WAIS 3 WMS 3 TECHNIC
   Witek MAG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094446
   Zald D. H., 2011, FRONTIERS NEUROSCIEN, P405
   Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 105
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JUL 15
PY 2014
VL 8
AR 192
DI 10.3389/fnins.2014.00192
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AW8GK
UT WOS:000346499100001
PM 25076869
ER

PT J
AU Vogan, VM
   Morgan, BR
   Lee, W
   Powell, TL
   Smith, ML
   Taylor, MJ
AF Vogan, Vanessa M.
   Morgan, Benjamin R.
   Lee, Wayne
   Powell, Tamara L.
   Smith, Mary Lou
   Taylor, Margot J.
TI The neural correlates of visuo-spatial working memory in children with
   autism spectrum disorder: effects of cognitive load
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Working memory; Autism spectrum disorder; Functional magnetic resonance
   imaging; Executive function; Cognitive load; Frontal lobe; Parietal lobe
ID HIGH-FUNCTIONING AUTISM; DORSAL VISUAL PATHWAY; EXECUTIVE FUNCTION;
   LEARNING-DIFFICULTIES; CORTICAL ACTIVATION; FRONTAL-CORTEX; GREY-MATTER;
   BRAIN; DEFICITS; FMRI
AB Background: Research on the neural bases of cognitive deficits in autism spectrum disorder (ASD) has shown that working memory (WM) difficulties are associated with abnormalities in the prefrontal cortex. However, cognitive load impacts these findings, and no studies have examined the relation between WM load and neural underpinnings in children with ASD. Thus, the current study determined the effects of cognitive load on WM, using a visuo-spatial WM capacity task in children with and without ASD with functional magnetic resonance imaging (fMRI).
   Methods: We used fMRI and a 1-back colour matching task (CMT) task with four levels of difficulty to compare the cortical activation patterns associated with WM in children (7-13 years old) with high functioning autism (N = 19) and matched controls (N = 17) across cognitive load.
   Results: Performance on CMT was comparable between groups, with the exception of one difficulty level. Using linear trend analyses, the control group showed increasing activation as a function of difficulty level in frontal and parietal lobes, particularly between the highest difficulty levels, and decreasing activation as a function of difficulty level in the posterior cingulate and medial frontal gyri. In contrast, children with ASD showed increasing activation only in posterior brain regions and decreasing activation in the posterior cingulate and medial frontal gyri, as a function of difficulty level. Significant differences were found in the precuneus, dorsolateral prefrontal cortex and medial premotor cortex, where control children showed greater positive linear relations between cortical activity and task difficulty level, particularly at the highest difficulty levels, but children with ASD did not show these trends.
   Conclusions: Children with ASD showed differences in activation in the frontal and parietal lobes-both critical substrates for visuo-spatial WM. Our data suggest that children with ASD rely mainly on posterior brain regions associated with visual and lower level processing, whereas controls showed activity in frontal lobes related to the classic WM network. Findings will help guide future work by localizing areas of vulnerability to developmental disturbances.
C1 [Vogan, Vanessa M.; Morgan, Benjamin R.; Lee, Wayne; Powell, Tamara L.; Smith, Mary Lou; Taylor, Margot J.] Hosp Sick Children, Diagnost Imaging & Res Inst, Toronto, ON M5G 1X8, Canada.
   [Vogan, Vanessa M.; Taylor, Margot J.] Univ Toronto, Ontario Inst Studies Educ, Dept Appl Psychol & Human Dev, Toronto, ON M5S 1V6, Canada.
   [Smith, Mary Lou; Taylor, Margot J.] Univ Toronto, Dept Psychol, Toronto, ON M5S 1V6, Canada.
RP Vogan, VM (reprint author), Hosp Sick Children, Diagnost Imaging & Res Inst, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM vanessa.vogan@sickkids.ca
FU Crescent School in Toronto; Canadian Institutes of Health Research
   [MOP-106582]
FX The authors would like to thank all of the families and children for
   their support and participation. We would also like to thank Rina Goukon
   for her assistance with participant recruitment and data collection.
   Many thanks to Rachel Leung and Becky Baatjes for administering the
   ADOS-R and ADOS-2 and Dr. Jessica Brian for reviewing all assessments.
   Sincere thanks to our MRI technicians, Ruth Weiss and Tammy Rayner, for
   all their support in data acquisition. The authors would also like to
   thank Marie Arsalidou for developing the CMT task and allowing us to use
   it. Lastly, thanks to Crescent School in Toronto for their support and
   participation in this project. This research was funded by Canadian
   Institutes of Health Research (MOP-106582) and preliminary analyses of
   these data were presented as a poster at the International Meeting for
   Autism Research (IMFAR) 2013.
CR Alloway TP, 2009, EUR J PSYCHOL ASSESS, V25, P92, DOI 10.1027/1015-5759.25.2.92
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Arsalidou M, 2010, COGNITIVE DEV, V25, P262, DOI 10.1016/j.cogdev.2010.07.001
   Arsalidou M, 2013, BRAIN BEHAV, V3, P273, DOI 10.1002/brb3.128
   Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
   Baddeley A, 2003, NAT REV NEUROSCI, V4, P829, DOI 10.1038/nrn1201
   BADDELEY A, 1992, SCIENCE, V255, P556, DOI 10.1126/science.1736359
   Barnard L, 2008, AUTISM, V12, P125, DOI 10.1177/1362361307088486
   Beauchamp MH, 2010, PSYCHOL BULL, V136, P39, DOI 10.1037/a0017768
   Benetto L, 1996, CHILD DEV, V67, P1816
   Bor D, 2003, NEURON, V37, P361, DOI 10.1016/S0896-6273(02)01171-6
   Carlson S, 1998, CEREB CORTEX, V8, P743, DOI 10.1093/cercor/8.8.743
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Chandana SR, 2005, INT J DEV NEUROSCI, V23, P171, DOI 10.1016/j.ijdevneu.2004.08.002
   Cohen JD, 1997, NATURE, V386, P604, DOI 10.1038/386604a0
   Cox RW, 1996, COMPUT BIOMED RES, V29, P162, DOI 10.1006/cbmr.1996.0014
   Dennis M, 2009, J CLIN EXP NEUROPSYC, V31, P835, DOI 10.1080/13803390802572419
   Duncan J, 2000, TRENDS NEUROSCI, V23, P475, DOI 10.1016/S0166-2236(00)01633-7
   Engle RW, 1999, J EXP PSYCHOL GEN, V128, P309, DOI 10.1037/0096-3445.128.3.309
   Finn AS, 2010, J NEUROSCI, V30, P11062, DOI 10.1523/JNEUROSCI.6266-09.2010
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   Fuster JM, 2000, BRAIN RES BULL, V52, P331, DOI 10.1016/S0361-9230(99)00258-0
   Greene CM, 2008, BIOL PSYCHOL, V79, P30, DOI 10.1016/j.biopsycho.2007.11.009
   Griebling J, 2010, J CHILD NEUROL, V25, P856, DOI 10.1177/0883073809351313
   Grinter EJ, 2010, BRAIN RES BULL, V82, P147, DOI 10.1016/j.brainresbull.2010.02.016
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hazlett HC, 2006, BIOL PSYCHIAT, V59, P1, DOI 10.1016/j.biopsych.2005.06.015
   Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hubl D, 2003, NEUROLOGY, V61, P1232
   Joseph RM, 1999, INT REV PSYCHIATR, V11, P309, DOI 10.1080/09540269974195
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
   KIRCHNER WK, 1958, J EXP PSYCHOL, V55, P352, DOI 10.1037/h0043688
   Klingberg T, 2002, J COGNITIVE NEUROSCI, V14, P1, DOI 10.1162/089892902317205276
   Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Kwon H, 2002, P NATL ACAD SCI USA, V99, P13336, DOI 10.1073/pnas.162486399
   Lainhart JE, 2006, AM J MED GENET C, V142C, P33, DOI 10.1002/ajmg.c.30080
   Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   Luna B, 2002, NEUROLOGY, V59, P834
   Mak-Fan KM, 2012, J AUTISM DEV DISORD, V42, P419, DOI 10.1007/s10803-011-1261-6
   McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
   Minshew NJ, 2001, J CHILD PSYCHOL PSYC, V42, P1095, DOI 10.1111/1469-7610.00808
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Nelson CA, 2000, DEV PSYCHOL, V36, P109, DOI 10.1037/0012-1649.36.1.109
   O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
   Olesen PJ, 2003, COGNITIVE BRAIN RES, V18, P48, DOI 10.1016/j.cogbrainres.2003.09.003
   Owen AM, 2005, HUM BRAIN MAPP, V25, P46, DOI 10.1002/hbm.20131
   Ozonoff S, 2001, J AUTISM DEV DISORD, V31, P257, DOI 10.1023/A:1010794902139
   PAAS FGWC, 1994, J EDUC PSYCHOL, V86, P122, DOI 10.1037/0022-0663.86.1.122
   Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
   Pellicano E, 2008, NEUROPSYCHOLOGIA, V46, P2593, DOI 10.1016/j.neuropsychologia.2008.04.008
   Pickering S. J., 2001, WORKING MEMORY TEST
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Powell KB, 2004, J CHILD NEUROL, V19, P785
   Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
   Russell J, 1996, J CHILD PSYCHOL PSYC, V37, P673, DOI 10.1111/j.1469-7610.1996.tb01459.x
   Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
   Rypma B, 2002, J COGNITIVE NEUROSCI, V14, P721, DOI 10.1162/08989290260138627
   Rypma B, 1999, NEUROIMAGE, V9, P216, DOI 10.1006/nimg.1998.0404
   Scherf KS, 2006, J COGNITIVE NEUROSCI, V18, P1045, DOI 10.1162/jocn.2006.18.7.1045
   Silk TJ, 2006, AM J PSYCHIAT, V163, P1440, DOI 10.1176/appi.ajp.163.8.1440
   Sowell ER, 2004, J NEUROSCI, V24, P8223, DOI 10.1523/JNEUROSCI.1798-04.2004
   Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031
   Steele SD, 2007, J AUTISM DEV DISORD, V37, P605, DOI 10.1007/s10803-006-0202-2
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014
   Ungerleider LG, 1982, ANAL VISUAL BEHAV, P549
   Wager TD, 2003, COGN AFFECT BEHAV NE, V3, P255, DOI 10.3758/CABN.3.4.255
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Whitfield-Gabrieli S, 2012, ANNU REV CLIN PSYCHO, V8, P49, DOI 10.1146/annurev-clinpsy-032511-143049
   Williams DL, 2008, MEMORY AUTISM
   Williams DL, 2005, J AUTISM DEV DISORD, V35, P747, DOI 10.1007/s10803-005-0021-x
   Woolrich Mark W, 2009, Neuroimage, V45, pS173, DOI 10.1016/j.neuroimage.2008.10.055
   Worsley K.J., 2001, FUNCTIONAL MRI INTRO
   ZILBOVICIUS M, 1995, AM J PSYCHIAT, V152, P248
NR 79
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUL 15
PY 2014
VL 6
AR 19
DI 10.1186/1866-1955-6-19
PG 15
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AL6ZU
UT WOS:000339283400001
PM 25057329
ER

PT J
AU Mostafa, GA
   El-Sherif, DF
   Ai-Ayadhi, LY
AF Mostafa, Gehan A.
   El-Sherif, Dalia F.
   Ai-Ayadhi, Laila Y.
TI Systemic auto-antibodies in children with autism
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Anti-ds-DNA antibodies; ANA, autism; Autoimmunity; Family history of
   autoimmunity
ID ELEVATED SERUM-LEVELS; LUPUS-ERYTHEMATOSUS; ANTINUCLEAR ANTIBODIES;
   AUTOIMMUNE-DISEASES; INCREASED FREQUENCY; FAMILY-HISTORY; ASSOCIATION;
   DISORDERS; PROTEIN; BRAIN
AB Autoimmunity to central nervous system may have a role in the pathogenesis of autism. A subset of anti-ds-DNA antibodies has been recently proved to be pathogenic to the brain as well as to the kidney. Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of anti-ds-DNA antibodies in a group of autistic children. The seropositivity of anti-nuclear antibodies (ANA) was also investigated. Serum anti-ds-DNA antibodies and ANA were measured in 100 autistic children, aged between 4 and 11 years, in comparison to 100 healthy-matched children. The seropositivity of anti-ds-DNA antibodies and ANA in autistic children was 34% and 25%, respectively. In addition, 42% of autistic children were seropositive for anti-ds-DNA antibodies and/or ANA. The frequencies of anti-ds-DNA antibodies and ANA in autistic children were significantly higher than that in healthy children (4% and 2%, respectively), (P < 0.001 and P < 0.001, respectively). Autistic children with a family history of autoimmunity (45%) had significantly higher frequency of serum anti-ds-DNA antibodies (48.9%) than patients without such a history (21.8%), P = 0.008. There was a significant positive association between the seropositivity of anti-ds-DNA antibodies and ANA (P < 0.001). In conclusion, anti-ds-DNA antibodies and ANA were found in the sera of a subgroup of autistic children. However, replication studies of larger samples are warranted to validate whether these antibodies are a mere association or have a pathogenic role in some autistic children. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Mostafa, Gehan A.; El-Sherif, Dalia F.] Ain Shams Univ, Fac Med, Dept Pediat, Cairo, Egypt.
   [Mostafa, Gehan A.; Ai-Ayadhi, Laila Y.] King Saud Univ, Fac Med, Autism Res & Treatment Ctr, Dept Physiol,Al Amodi Autism Res Chair, Riyadh, Saudi Arabia.
RP Mostafa, GA (reprint author), 9 Ahmed El Samman St Makram Ebaid, Cairo 11511, Egypt.
EM gehan.mostafa2000@yahoo.com
FU King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia;
   NPST, Health Research and Studies Program at Kind Saud University
FX This work was financially supported by the King Abdulaziz City for
   Science and Technology, Riyadh, Saudi Arabia. It was also supported by
   NPST, Health Research and Studies Program at Kind Saud University.
CR Al-Ayadhi LY, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-54
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445
   Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8
   Comi AM, 1999, J CHILD NEUROL, V14, P388, DOI 10.1177/088307389901400608
   Connolly AM, 1999, J PEDIATR-US, V134, P607, DOI 10.1016/S0022-3476(99)70248-9
   DeGiorgio LA, 2001, NAT MED, V7, P1189, DOI 10.1038/nm1101-1189
   Diamond B, 2011, J INTERN MED, V269, P36, DOI 10.1111/j.1365-2796.2010.02318.x
   Dorner T, 1999, CLIN IMMUNOL, V92, P188, DOI 10.1006/clim.1999.4740
   Enstrom AM, 2009, CURR OPIN INVEST DR, V10, P463
   Gaynor B, 1997, P NATL ACAD SCI USA, V94, P1955, DOI 10.1073/pnas.94.5.1955
   Ghillani P, 2007, ANN NY ACAD SCI, V1109, P407, DOI 10.1196/annals.1398.046
   Hahn BH, 1998, NEW ENGL J MED, V338, P1359
   Jones R., 2010, TRIALS, V10, P57
   Li ZQ, 2004, GENE DEV, V18, P1, DOI 10.1101/gad.1161904
   Miller M.L., 2012, NELSON TXB PEDIAT, P997
   Miller M.L., 2008, NELSON TXB PEDIAT, P997
   Mostafa GA, 2013, J NEUROIMMUNOL, V261, P77, DOI 10.1016/j.jneuroim.2013.04.003
   Mostafa GA, 2009, PEDIATR NEUROL, V40, P107, DOI 10.1016/j.pediatrneurol.2008.10.017
   Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-39
   Mostafa GA, 2012, EUR J PAEDIATR NEURO, V16, P464, DOI 10.1016/j.ejpn.2011.12.010
   Mostafa GA, 2008, J CHILD NEUROL, V23, P1413, DOI 10.1177/0883073808319321
   Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-180
   Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-71
   Mostafa GA, 2010, J NEUROIMMUNOL, V223, P115, DOI 10.1016/j.jneuroim.2010.03.025
   Mostafa GA, 2010, J CHILD NEUROL, V25, P328, DOI 10.1177/0883073809339393
   Mostafa GA, 2010, J NEUROIMMUNOL, V219, P114, DOI 10.1016/j.jneuroim.2009.12.003
   Muro Y, 2005, AUTOIMMUNITY, V38, P3, DOI 10.1080/08916930400024612
   Neri F, 2004, LUPUS, V13, P805, DOI 10.1191/0961203304lu2018oa
   Ronnblom L, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar2884
   Schopler E., 1986, CHILDHOOD AUTISM RAT
   Sharma A, 2003, RHEUMATOLOGY, V42, P453, DOI 10.1093/rheumatology/keg161
   Singh VK, 1998, CLIN IMMUNOL IMMUNOP, V89, P105, DOI 10.1006/clin.1998.4588
   Singh VK, 2004, NEUROSCI LETT, V355, P53, DOI 10.1016/j.neulet.2003.10.026
   Sweeten T.L., 2003, PEDIATRICS, V112, P420
   Vanchu A., 2000, J POSTGRAD MED, V46, P144
   Vojdani A, 2002, J NEUROIMMUNOL, V129, P168, DOI 10.1016/S0165-5728(02)00180-7
   Yung S, 2012, CLIN DEV IMMUNOL, DOI 10.1155/2012/139365
NR 38
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD JUL 15
PY 2014
VL 272
IS 1-2
BP 94
EP 98
DI 10.1016/j.jneuroim.2014.04.011
PG 5
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA AK7MX
UT WOS:000338613500014
PM 24837704
ER

PT J
AU Di Nardo, A
   Wertz, MH
   Kwiatkowski, E
   Tsai, PT
   Leech, JD
   Greene-Colozzi, E
   Goto, J
   Dilsiz, P
   Talos, DM
   Clish, CB
   Kwiatkowski, DJ
   Sahin, M
AF Di Nardo, Alessia
   Wertz, Mary H.
   Kwiatkowski, Erica
   Tsai, Peter T.
   Leech, Jarrett D.
   Greene-Colozzi, Emily
   Goto, June
   Dilsiz, Pelin
   Talos, Delia M.
   Clish, Clary B.
   Kwiatkowski, David J.
   Sahin, Mustafa
TI Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent
   regulation of ULK1
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID TUBEROUS SCLEROSIS COMPLEX; ACTIVATED PROTEIN-KINASE; NEURODEGENERATIVE
   DISEASES; SERINE/THREONINE KINASE; CAENORHABDITIS-ELEGANS;
   HUNTINGTONS-DISEASE; ENHANCE AUTOPHAGY; PHOSPHORYLATION; DYSFUNCTION;
   CELLS
AB Tuberous sclerosis complex (TSC) is a disorder arising from mutation in the TSC1 or TSC2 gene, characterized by the development of hamartomas in various organs and neurological manifestations including epilepsy, intellectual disability and autism. TSC1/2 protein complex negatively regulates the mammalian target of rapamycin complex 1 (mTORC1) a master regulator of protein synthesis, cell growth and autophagy. Autophagy is a cellular quality-control process that sequesters cytosolic material in double membrane vesicles called autophagosomes and degrades it in autolysosomes. Previous studies in dividing cells have shown that mTORC1 blocks autophagy through inhibition of Unc-51-like-kinase1/2 (ULK1/2). Despite the fact that autophagy plays critical roles in neuronal homeostasis, little is known on the regulation of autophagy in neurons. Here we show that unlike in non-neuronal cells, Tsc2-deficient neurons have increased autolysosome accumulation and autophagic flux despite mTORC1-dependent inhibition of ULK1. Our data demonstrate that loss of Tsc2 results in autophagic activity via AMPK-dependent activation of ULK1. Thus, in Tsc2-knockdown neurons AMPK activation is the dominant regulator of autophagy. Notably, increased AMPK activity and autophagy activation are also found in the brains of Tsc1-conditional mouse models and in cortical tubers resected from TSC patients. Together, our findings indicate that neuronal Tsc1/2 complex activity is required for the coordinated regulation of autophagy by AMPK. By uncovering the autophagy dysfunction associated with Tsc2 loss in neurons, our work sheds light on a previously uncharacterized cellular mechanism that contributes to altered neuronal homeostasis in TSC disease.
C1 [Di Nardo, Alessia; Wertz, Mary H.; Kwiatkowski, Erica; Tsai, Peter T.; Leech, Jarrett D.; Greene-Colozzi, Emily; Sahin, Mustafa] Harvard Univ, Sch Med, Childrens Hosp Boston, FM Kirby Neurobiol Ctr,Dept Neurol, Boston, MA 02115 USA.
   [Goto, June; Kwiatkowski, David J.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Translat Med,Dept Med, Boston, MA 02115 USA.
   [Dilsiz, Pelin; Talos, Delia M.] NYU, Sch Med, Dept Neurol, New York, NY 10016 USA.
   [Clish, Clary B.] Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA 02142 USA.
RP Sahin, M (reprint author), Childrens Hosp, Dept Neurol, 300 Longwood Ave,CLSB 13074, Boston, MA 02115 USA.
EM mustafa.sahin@childrens.harvard.edu
FU Nancy Lurie Marks Family Foundation; Autism Speaks; Boston Children's
   Hospital Translational Research Program; National Institute of Health
   [P01 NS024279, K08 NS083733]; Tuberous Sclerosis Alliance; FACES
   [Finding a Cure for Epilepsy and Seizures]; National Institute of Child
   Health and Human Development-Brain and Tissue Bank for Developmental
   Disorders at the University of Maryland, Baltimore, MD, USA
   [HHSN275200900011C, N01-HD-9-0011]
FX This work was supported by Nancy Lurie Marks Family Foundation, Autism
   Speaks and Boston Children's Hospital Translational Research Program (to
   M. S.), National Institute of Health [P01 NS024279 (to D.J.K.) and K08
   NS083733 (to P. T. T.)], the Tuberous Sclerosis Alliance (to A.D.N.),
   FACES [Finding a Cure for Epilepsy and Seizures (to D. M. T.)]. Control
   human tissue was obtained from the National Institute of Child Health
   and Human Development-Brain and Tissue Bank for Developmental Disorders
   at the University of Maryland, Baltimore, MD, USA, contract
   HHSN275200900011C, Ref. No. N01-HD-9-0011.
CR Alers S, 2012, MOL CELL BIOL, V32, P2, DOI 10.1128/MCB.06159-11
   Anderl S, 2011, HUM MOL GENET, V20, P4597, DOI 10.1093/hmg/ddr393
   Arsham AM, 2006, CURR OPIN CELL BIOL, V18, P589, DOI 10.1016/j.ceb.2006.09.005
   Chang YY, 2009, MOL BIOL CELL, V20, P2004, DOI 10.1091/mbc.E08-12-1250
   Choi YJ, 2008, GENE DEV, V22, P2485, DOI 10.1101/gad.1685008
   Di Nardo A, 2009, J NEUROSCI, V29, P5926, DOI 10.1523/JNEUROSCI.0778-09.2009
   Egan DF, 2011, SCIENCE, V331, P456, DOI 10.1126/science.1196371
   Ganley IG, 2009, J BIOL CHEM, V284, P12297, DOI 10.1074/jbc.M900573200
   Garelick MG, 2011, EXP GERONTOL, V46, P155, DOI 10.1016/j.exger.2010.08.030
   Goto J, 2011, P NATL ACAD SCI USA, V108, pE1070, DOI 10.1073/pnas.1106454108
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Han JM, 2011, FEBS LETT, V585, P973, DOI 10.1016/j.febslet.2011.02.001
   Hara T, 2006, NATURE, V441, P885, DOI 10.1038/nature04724
   Huang JX, 2009, BIOCHEM SOC T, V37, P217, DOI 10.1042/BST0370217
   Inoki K, 2002, NAT CELL BIOL, V4, P648, DOI 10.1038/ncb839
   Jung CH, 2009, MOL BIOL CELL, V20, P1992, DOI 10.1091/mbc.E08-12-1249
   Kabeya Y, 2000, EMBO J, V19, P5720, DOI 10.1093/emboj/19.21.5720
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Klionsky DJ, 2012, AUTOPHAGY, V8, P445, DOI 10.4161/auto.19496
   Korolchuk VI, 2011, AUTOPHAGY, V7, P927, DOI 10.4161/auto.7.8.15862
   Lee CH, 2010, BRIT J DERMATOL, V163, P1238, DOI 10.1111/j.1365-2133.2010.09971.x
   Meley D, 2006, J BIOL CHEM, V281, P34870, DOI 10.1074/jbc.M605488200
   Mizushima N, 2008, NATURE, V451, P1069, DOI 10.1038/nature06639
   Moussay E, 2011, AUTOPHAGY, V7, P760, DOI 10.4161/auto.7.7.15454
   Murrow L, 2013, ANNU REV PATHOL-MECH, V8, P105, DOI 10.1146/annurev-pathol-020712-163918
   Nie D, 2010, NAT NEUROSCI, V13, P163, DOI 10.1038/nn.2477
   Ogura K, 2006, DEVELOPMENT, V133, P3441, DOI 10.1242/dev.02503
   OGURA K, 1994, GENE DEV, V8, P2389, DOI 10.1101/gad.8.20.2389
   Pankiv S, 2007, J BIOL CHEM, V282, P24131, DOI 10.1074/jbc.M702824200
   Papadakis M, 2013, NAT MED, V19, P351, DOI 10.1038/nm.3097
   Parkhitko A, 2011, P NATL ACAD SCI USA, V108, P12455, DOI 10.1073/pnas.1104361108
   Qin L, 2010, AUTOPHAGY, V6, P239
   Renna M, 2011, J CELL SCI, V124, P469, DOI 10.1242/jcs.076489
   Rouschop KMA, 2010, J CLIN INVEST, V120, P127, DOI 10.1172/JCI40027
   Sarkar S, 2007, NAT CHEM BIOL, V3, P331, DOI 10.1038/nchembio883
   Sarkar S, 2013, BIOCHEM SOC T, V41, P1103, DOI 10.1042/BST20130134
   Sato A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2295
   Settembre C, 2011, SCIENCE, V332, P1429, DOI 10.1126/science.1204592
   Son JH, 2012, EXP MOL MED, V44, P89, DOI 10.3858/emm.2012.44.2.031
   Toda H, 2008, GENE DEV, V22, P3292, DOI 10.1101/gad.1734608
   Tomoda T, 1999, NEURON, V24, P833, DOI 10.1016/S0896-6273(00)81031-4
   Tsai P, 2011, CURR OPIN NEUROL, V24, P106, DOI 10.1097/WCO.0b013e32834451c4
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Tsvetkov AS, 2010, P NATL ACAD SCI USA, V107, P16982, DOI 10.1073/pnas.1004498107
   Williams A, 2008, NAT CHEM BIOL, V4, P295, DOI 10.1038/nchembio.79
   Zhang JW, 2013, NAT CELL BIOL, V15, P1186, DOI 10.1038/ncb2822
NR 46
TC 6
Z9 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD JUL 15
PY 2014
VL 23
IS 14
BP 3865
EP 3874
DI 10.1093/hmg/ddu101
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AK7TJ
UT WOS:000338630300021
PM 24599401
ER

PT J
AU Forrester, GS
   Pegler, R
   Thomas, MSC
   Mareschal, D
AF Forrester, Gillian S.
   Pegler, Ruth
   Thomas, Michael S. C.
   Mareschal, Denis
TI Handedness as a marker of cerebral lateralization in children with and
   without autism
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Cerebral lateralization; Handedness; Autism; Self-directed behavior
ID CHIMPANZEES PAN-TROGLODYTES; HAND PREFERENCE; SPECTRUM DISORDERS;
   NONHUMAN-PRIMATES; DEVELOPMENTAL INSTABILITY; EMOTIONAL VALENCE;
   YOUNG-CHILDREN; BRAIN; ASYMMETRIES; LANGUAGE
AB We employed a multiple case studies approach to investigate lateralization of hand actions in typically and atypically developing children between 4 and 5 years of age. We report on a detailed set of over 1200 hand actions made by four typically developing boys and four boys with autism. Participants were assessed for unimanual hand actions to both objects and the self (self-directed behaviors). Individual and group analyses suggest that typically developing children have a right hand dominance for hand actions to objects and a left hand dominance for hand actions for self-directed behaviors, revealing a possible dissociation for functional specialization of the left and right hemispheres respectively. Children with autism demonstrated mixed-handedness for both target conditions, consistent with the hypothesis that there is reduced cerebral specialization in these children. The findings are consistent with the view that observed lateralized motor action can serve as an indirect behavioral marker for evidence of cerebral lateralization. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Forrester, Gillian S.; Pegler, Ruth] Univ Westminster, Dept Psychol, London W1B 2HW, England.
   [Thomas, Michael S. C.; Mareschal, Denis] Birkbeck Univ London, Dept Psychol Sci, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
RP Forrester, GS (reprint author), Univ Westminster, Dept Psychol, 309 Regent St, London W1B 2HW, England.
EM g.forrester@westminster.ac.uk
FU European (ANALOGY) [FP6-NEST-029088]; European (ACT)
   [FP7-MC-ITN-289404]; ESRC [RES-062-23-2721]; University of Westminster's
   Psychology Publication Stimulus Scheme
FX We are grateful to the parents, teachers and children of Livingstone
   Primary School for their participation and to Dr. Kristelle Hudry for
   conducting diagnostic testing. We gratefully acknowledge funding support
   provided in part by European Grants: FP6-NEST-029088(ANALOGY),
   FP7-MC-ITN-289404(ACT), ESRC grant RES-062-23-2721 and the University of
   Westminster's Psychology Publication Stimulus Scheme.
CR ALTMANN J, 1974, BEHAVIOUR, V49, P227, DOI 10.1163/156853974X00534
   ANNETT M, 1970, BRIT J PSYCHOL, V61, P545
   Bates E, 1986, DEV NEUROPSYCHOL, V2, P1, DOI 10.1080/87565648609540323
   Beaton AA, 2003, BRAIN ASYMMETRY, P105
   BOROD JC, 1984, BRIT J PSYCHOL, V75, P177
   Broca P., 1865, B SOC ANTHROPOL PAR, V6, P377
   BRYDEN MP, 1991, CORTEX, V27, P229
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cochet H, 2011, J EXP CHILD PSYCHOL, V110, P393, DOI 10.1016/j.jecp.2011.04.009
   Cochet H, 2010, GESTURE, V10, P129, DOI 10.1075/gest.10.2-3.02coc
   Cochet H., 2010, INFANT BEHAV DEV, V33, P432, DOI DOI 10.1016/J.INFBEH.2010.04.009)
   Coren S, 1992, LEFT HANDER SYNDROME
   Crow TJ, 1998, NEUROPSYCHOLOGIA, V36, P1275, DOI 10.1016/S0028-3932(98)00039-6
   Dane S, 2007, INT J DEV NEUROSCI, V25, P223, DOI 10.1016/j.ijdevneu.2007.03.005
   DAVIDSON RJ, 1990, J PERS SOC PSYCHOL, V58, P330, DOI 10.1037/0022-3514.58.2.330
   Davidson Richard J., 1995, P361
   de Souza Silva MA, 2005, BRAIN RES B, V74, P416
   Delcato CH, 1966, NEUROLOGICAL ORG REA
   DIMOND S, 1984, NEUROPSYCHOLOGIA, V22, P227, DOI 10.1016/0028-3932(84)90065-4
   EKMAN P, 1969, PSYCHIATR, V32, P88
   EKMAN P, 1972, J COMMUN, V22, P353, DOI 10.1111/j.1460-2466.1972.tb00163.x
   Ekman P., 1977, ASA MONOGRAPH, V15
   Elias LJ, 1998, NEUROPSYCHOLOGIA, V36, P37, DOI 10.1016/S0028-3932(97)00107-3
   Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
   Esseily R, 2011, LATERALITY, V16, P565, DOI 10.1080/1357650X.2010.499911
   Everhart DE, 1996, PERCEPT MOTOR SKILL, V82, P264
   Fagard J, 2005, INFANT BEHAV DEV, V28, P305, DOI 10.1016/j.infbeh.2005.05.005
   Fagard J, 2000, DEVELOPMENTAL SCI, V3, P137, DOI 10.1111/1467-7687.00107
   FAGOT J, 1991, PSYCHOL BULL, V109, P76, DOI 10.1037//0033-2909.109.1.76
   Flowers K, 1975, BRIT J PSYCHOL, V66, P49
   Forrester GS, 2013, BEHAV BRAIN RES, V237, P200, DOI 10.1016/j.bbr.2012.09.037
   Forrester GS, 2008, ANIM BEHAV, V76, P1749, DOI 10.1016/j.anbehav.2008.05.026
   Forrester GS, 2012, ANIM COGN, V15, P1121, DOI 10.1007/s10071-012-0536-4
   Forrester GS, 2011, ANIM COGN, V14, P903, DOI 10.1007/s10071-011-0413-6
   FOUNDAS AL, 1995, ARCH NEUROL-CHICAGO, V52, P501
   Frasnelli E, 2012, NEUROSCI BIOBEHAV R, V36, P1273, DOI 10.1016/j.neubiorev.2012.02.006
   GUDMUNDSSON E, 1993, PERCEPT MOTOR SKILL, V77, P819
   Hauck JA, 2001, J AUTISM DEV DISORD, V31, P265, DOI 10.1023/A:1010791118978
   HEALEY JM, 1986, CORTEX, V22, P33
   Hellige JB, 1993, CURRENT DIRECTIONS P, V2, P21, DOI DOI 10.1111/1467-8721.EP10770559
   Herve PY, 2006, NEUROIMAGE, V29, P1066, DOI 10.1016/j.neuroimage.2005.08.031
   Hinojosa T, 2003, DEV PSYCHOBIOL, V43, P328, DOI 10.1002/dev.10142
   Hopkins WD, 1999, INT J PRIMATOL, V20, P851, DOI 10.1023/A:1020822401195
   Hopkins WD, 2001, J COMP PSYCHOL, V115, P294
   Hopkins WD, 2006, EMOTION, V6, P553, DOI 10.1037/1528-3542.6.4.553
   HURLBERT SH, 1984, ECOL MONOGR, V54, P187, DOI 10.2307/1942661
   Hutchins E., 2006, ROOTS HUMAN SOCIALIT, P375
   HUTCHINS E., 1995, COGNITION WILD
   INGRAM D, 1975, NEUROPSYCHOLOGIA, V13, P95, DOI 10.1016/0028-3932(75)90052-4
   Jacquet AY, 2011, DEV PSYCHOL, V54, P36
   Johnson CM, 2001, ANIMAL COGNITION, V3, P167
   Kastner-Koller U., 2007, PSYCHOL SCI, V49, P239
   Knaus TA, 2010, BRAIN LANG, V112, P113, DOI 10.1016/j.bandl.2009.11.005
   Knecht S, 2000, BRAIN, V123, P2512, DOI 10.1093/brain/123.12.2512
   Leask SJ, 2001, TRENDS COGN SCI, V5, P513, DOI 10.1016/S1364-6613(00)01795-2
   Leavens DA, 2001, AM J PRIMATOL, V55, P1, DOI 10.1002/ajp.1034
   Leonard HC, 2014, EUR J DEV PSYCHOL, V11, P18, DOI 10.1080/17405629.2013.801626
   LEWIN J, 1993, BRIT J PSYCHIAT, V163, P674, DOI 10.1192/bjp.163.5.674
   Lindell AK, 2013, NEUROPSYCHOL REV, V23, P257, DOI 10.1007/s11065-013-9234-5
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MacNeilage PF, 2009, SCI AM, V301, P60
   MacWhinney B, 2007, CREATING AND DIGITIZING LANGUAGE CORPORA VOLUME 1: SYNCHRONIC DATABASES, P163
   MAESTRIPIERI D, 1992, ANIM BEHAV, V44, P967, DOI 10.1016/S0003-3472(05)80592-5
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   MARCHANT LF, 1995, ETHOLOGY, V101, P239
   MCFARLAND RA, 1989, PERCEPT MOTOR SKILL, V68, P435
   McGrew WC, 1997, YEARB PHYS ANTHROPOL, V40, P201
   McManus I. C., 2002, RIGHT HAND LEFT HAND
   MCMANUS IC, 1988, BRIT J DEV PSYCHOL, V6, P257
   Meador KJ, 1999, NEUROLOGY, V53, P2028
   NATALE M, 1983, NEUROPSYCHOLOGIA, V21, P555, DOI 10.1016/0028-3932(83)90011-8
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Onal-Hartmann C, 2012, PSYCHOL RES-PSYCH FO, V76, P311, DOI 10.1007/s00426-011-0337-4
   Orton S. T., 1937, READING WRITING SPEE
   Palmer AR, 2003, AM J PHYS ANTHROPOL, V121, P382, DOI 10.1002/ajpa.10177
   Potier C, 2013, LATERALITY, V18, P576, DOI 10.1080/1357650X.2012.732077
   PROVINS KA, 1968, Q J EXP PSYCHOL, V20, P282, DOI 10.1080/14640746808400162
   Rodriguez A, 2010, PEDIATRICS, V125, P340
   Rogers LJ, 2004, P ROY SOC B-BIOL SCI, V271, pS420, DOI 10.1098/rsbl.2004.0200
   Rogers LJ, 1996, ANIM BEHAV, V51, P13, DOI 10.1006/anbe.1996.0002
   Rogers L.J., 2002, COMP VERTEBRATE LATE
   Santrock JW, 2008, TOPICAL APPROACH LIF, P172
   SATZ P, 1989, NEUROPSYCHOLOGIA, V27, P1309, DOI 10.1016/0028-3932(89)90043-2
   SATZ P, 1985, PSYCHIAT ANN, V15, P447
   Shamay-Tsoory SG, 2008, BRAIN COGNITION, V67, P280, DOI 10.1016/j.bandc.2008.02.001
   SOPER HV, 1986, J AUTISM DEV DISORD, V16, P155, DOI 10.1007/BF01531727
   Szaflarski JP, 2002, NEUROLOGY, V59, P238
   Tager-Flusberg H, 2007, PEDIATR CLIN N AM, V54, P469, DOI 10.1016/j.pcl.2007.02.011
   Thomas MSC, 2011, PSYCHOL REV, V118, P637, DOI 10.1037/a0025234
   Toga AW, 2003, NAT REV NEUROSCI, V4, P37, DOI 10.1038/nrn1009
   Tommasi L, 2009, PHILOS T R SOC B, V364, P855, DOI 10.1098/rstb.2008.0293
   Triosi A, 2002, STRESS, V5, P47
   TSAI LY, 1984, J AUTISM DEV DISORD, V14, P447, DOI 10.1007/BF02409836
   Vallortigara G, 2005, BEHAV BRAIN SCI, V28, P575, DOI 10.1017/S0140525X05000105
   WAXER PH, 1977, J ABNORM PSYCHOL, V86, P306, DOI 10.1037//0021-843X.86.3.306
   Wernicke C, 1874, APHASICHE SYMPTOMENK
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Whiteley P, 2010, AUTISM INSIGHTS, V2, P17
   WHO Multicentre Growth Reference Study Group, 2006, ACTA PAEDIATR, V450, P86
   Yeo RA, 1997, NEUROPSYCHOLOGY, V11, P552, DOI 10.1037//0894-4105.11.4.552
   Yeo RA, 2007, CURR DIR PSYCHOL SCI, V16, P245, DOI 10.1111/j.1467-8721.2007.00513.x
NR 101
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 15
PY 2014
VL 268
BP 14
EP 21
DI 10.1016/j.bbr.2014.03.040
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AJ4MQ
UT WOS:000337650900003
PM 24704491
ER

PT J
AU Weidner, KL
   Buenaventura, DF
   Chadman, KK
AF Weidner, Kate L.
   Buenaventura, Diego F.
   Chadman, Kathryn K.
TI Mice over-expressing BDNF in forebrain neurons develop an altered
   behavioral phenotype with age
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Brain derived neurotrophic factor; Transgenic mice; Autism; Social
   approach; Behavioral phenotype
ID MARBLE-BURYING BEHAVIOR; NEUROTROPHIC FACTOR; EPILEPTIFORM ACTIVITY;
   OVEREXPRESSING MICE; SPECTRUM DISORDERS; MENTAL-RETARDATION; INBRED
   STRAINS; PROTEIN-LEVELS; AUTISM; MOUSE
AB Evidence from clinical studies suggests that abnormal activity of brain derived neurotrophic factor (BDNF) contributes to the pathogenesis of autism spectrum disorders (ASDs). A genetically modified line of mice over-expressing a BDNF transgene in forebrain neurons was used to investigate if this mutation leads to changes in behavior consistent with ASD. The mice used in these experiments were behaviorally tested past 5 months of age when spontaneous seizures were evident. These seizures were not observed in age-matched wildtype (WT) mice or younger mice from this transgenic line. The BDNF mice in these experiments weighed less than their WT littermates. The BDNF transgenic (BDNF-tg) mice demonstrated similar levels of sociability in the social approach test. Conversely, the BDNF-tg mice demonstrated less obsessive compulsive-like behavior in the marble burying test, less anxiety-like behavior in the elevated plus maze test, and less depressive-like behavior in the forced swim test. Changes in behavior were found in these older mice that have not been observed in younger mice from this transgenic line, which may be due to the development of seizures as the mice age. These mice do not have an ASD phenotype but may be useful to study adult onset epilepsy. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Weidner, Kate L.; Buenaventura, Diego F.] CUNY Coll Staten Isl, Staten Isl, NY 10314 USA.
   [Weidner, Kate L.; Buenaventura, Diego F.; Chadman, Kathryn K.] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA.
RP Chadman, KK (reprint author), New York State Inst Basic Res Dev Disabil, Dept Dev Neurobiol, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM klw7fu@virginia.edu; kathryn.chadman@opwdd.ny.gov
FU New York State Office for People with Developmental Disabilities; Center
   for Developmental Neuroscience at the College of Staten Island, City
   University of New York
FX This work was supported by the New York State Office for People with
   Developmental Disabilities and was done in conjunction with the Center
   for Developmental Neuroscience at the College of Staten Island, City
   University of New York. We thank Dr. G.Y. Wen for PCR equipment and Dr.
   J.N. Crawley for the gift of the original BDNF-tg breeding pairs. We
   also thank Drs. G.Y. Wen and S.R. Guariglia, for critical reading of the
   manuscript.
CR Balu DT, 2008, BRAIN RES, V1211, P37, DOI 10.1016/j.brainres.2008.03.023
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Castagne V, 2009, EUR J PHARMACOL, V616, P128, DOI 10.1016/j.ejphar.2009.06.018
   Chadman KK, 2011, PHARMACOL BIOCHEM BE, V97, P586, DOI 10.1016/j.pbb.2010.09.012
   Chadman KK, 2009, AM J MED GENET B, V150B, P1, DOI 10.1002/ajmg.b.30777
   Connolly AM, 2006, BIOL PSYCHIAT, V59, P354, DOI 10.1016/j.biopsych.2005.07.004
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Croll SD, 1999, NEUROSCIENCE, V93, P1491, DOI 10.1016/S0306-4522(99)00296-1
   Cunha C, 2009, NEUROBIOL DIS, V33, P358, DOI 10.1016/j.nbd.2008.11.004
   Deltheil T, 2008, NEUROPHARMACOLOGY, V55, P1006, DOI 10.1016/j.neuropharm.2008.08.001
   Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
   Enstrom A, 2008, AM J BIOCH BIOTECHNO, V4, P121, DOI DOI 10.3844/AJBBSP.2008.121.129
   Govindarajan A, 2006, P NATL ACAD SCI USA, V103, P13208, DOI 10.1073/pnas.0605180103
   Groen W, 2010, J AM ACAD CHILD PSY, V49, P552, DOI 10.1016/j.jaac.2009.12.023
   Hrdlicka M, 2004, EUR CHILD ADOLES PSY, V13, P209, DOI 10.1007/s00787-004-0353-7
   Huang ZJ, 1999, CELL, V98, P739, DOI 10.1016/S0092-8674(00)81509-3
   Kernie SG, 2000, EMBO J, V19, P1290, DOI 10.1093/emboj/19.6.1290
   Lahteinen S, 2002, EUR J NEUROSCI, V15, P721
   Levisohn PM, 2007, EPILEPSIA, V48, P33, DOI 10.1111/j.1528-1167.2007.01399.x
   Lewine JD, 1999, PEDIATRICS, V104, P405, DOI 10.1542/peds.104.3.405
   Lyons WE, 1999, P NATL ACAD SCI USA, V96, P15239, DOI 10.1073/pnas.96.26.15239
   Martinowich K, 2007, NAT NEUROSCI, V10, P1089, DOI 10.1038/nn1971
   Matsushita M, 2005, J PHARMACOL SCI, V99, P154, DOI 10.1254/jphs.FP0050144
   Miyazaki K, 2004, BRAIN DEV-JPN, V26, P292, DOI 10.1016/S0387-7604(03)00168-2
   Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   Papaleo F, 2011, LEARN MEMORY, V18, P534, DOI 10.1101/lm.2213711
   Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058
   PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
   RACINE RJ, 1972, BRAIN RES, V47, P262, DOI 10.1016/0006-8993(72)90268-5
   ROSSI PG, 1995, BRAIN DEV-JPN, V17, P169, DOI 10.1016/0387-7604(95)00019-8
   Scharfman HE, 1999, J NEUROSCI, V19, P5619
   Scharfman HE, 2002, EXP NEUROL, V174, P201, DOI 10.1006/exnr.2002.7869
   Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007
   Shirayama Y, 2002, J NEUROSCI, V22, P3251
   Siuciak JA, 1996, BRAIN RES, V710, P11, DOI 10.1016/0006-8993(95)01289-3
   Slot LAB, 2008, BEHAV PHARMACOL, V19, P145
   Soliman F, 2010, SCIENCE, V327, P863, DOI 10.1126/science.1181886
   Thomas A, 2009, PSYCHOPHARMACOLOGY B
   Tsai SJ, 2005, MED HYPOTHESES, V65, P79, DOI 10.1016/j.mehy.2005.01.034
   Vaccarino FM, 2009, BIOL PSYCHIAT, V66, P313, DOI 10.1016/j.biopsych.2009.06.013
   Weidner KL, 2011, AGING DIS, V2, P308
NR 44
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 15
PY 2014
VL 268
BP 222
EP 228
DI 10.1016/j.bbr.2014.04.025
PG 7
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AJ4MQ
UT WOS:000337650900026
PM 24768643
ER

PT J
AU Park, MTM
   Pipitone, J
   Baer, LH
   Winterburn, JL
   Shah, Y
   Chavez, S
   Schira, MM
   Lobaugh, NJ
   Lerch, JP
   Voineskos, AN
   Chakravarty, MM
AF Park, Min Tae M.
   Pipitone, Jon
   Baer, Lawrence H.
   Winterburn, Julie L.
   Shah, Yashvi
   Chavez, Sofia
   Schira, Mark M.
   Lobaugh, Nancy J.
   Lerch, Jason P.
   Voineskos, Aristotle N.
   Chakravarty, M. Mallar
TI Derivation of high-resolution MRI atlases of the human cerebellum at 3 T
   and segmentation using multiple automatically generated templates
SO NEUROIMAGE
LA English
DT Article
DE MRI; High resolution; Atlas; Cerebellum; Lobule; Automatic
ID INTRINSIC FUNCTIONAL CONNECTIVITY; COGNITIVE-AFFECTIVE SYNDROME;
   MAGNETIC-RESONANCE; ALZHEIMERS-DISEASE; ONSET SCHIZOPHRENIA; WARPING
   TECHNIQUES; BRAIN; REGISTRATION; AUTISM; VERMIS
AB The cerebellum has classically been linked to motor learning and coordination. However, there is renewed interest in the role of the cerebellum in non-motor functions such as cognition and in the context of different neuropsychiatric disorders. The contribution of neuroimaging studies to advancing understanding of cerebellar structure and function has been limited, partly due to the cerebellum being understudied as a result of contrast and resolution limitations of standard structural magnetic resonance images (MRI). These limitations inhibit proper visualization of the highly compact and detailed cerebellar foliations. In addition, there is a lack of robust algorithms that automatically and reliably identify the cerebellum and its subregions, further complicating the design of large-scale studies of the cerebellum. As such, automated segmentation of the cerebellar lobules would allow detailed population studies of the cerebellum and its subregions. In this manuscript, we describe a novel set of high-resolution in vivo atlases of the cerebellum developed by pairing MR imaging with a carefully validated manual segmentation protocol. Using these cerebellar atlases as inputs, we validate a novel automated segmentation algorithm that takes advantage of the neuroanatomical variability that exists in a given population under study in order to automatically identify the cerebellum, and its lobules. Our automatic segmentation results demonstrate good accuracy in the identification of all lobules (mean Kappa [kappa] = 0.731; range 0.40-0.89), and the entire cerebellum (means kappa = 0.925; range 0.90-0.94) when compared to "gold-standard" manual segmentations. These results compare favorably in comparison to other publically available methods for automatic segmentation of the cerebellum. The completed cerebellar atlases are available freely online (http://imaging-genetics.camh.ca/cerebellum) and can be customized to the unique neuroanatomy of different subjects using the proposed segmentation pipeline (https://github.com/pipitone/MAGeTbrain). (C) 2014 Elsevier Inc. All rights reserved.
C1 [Park, Min Tae M.; Pipitone, Jon; Winterburn, Julie L.; Shah, Yashvi; Voineskos, Aristotle N.; Chakravarty, M. Mallar] Ctr Addict & Mental Hlth, Res Imaging Ctr, Kimel Family Translat Imaging Genet Res Lab, Toronto, ON M5T 1R8, Canada.
   [Baer, Lawrence H.] Concordia Univ, Dept Psychol, Montreal, PQ H3G 1M8, Canada.
   [Chavez, Sofia; Lobaugh, Nancy J.] Ctr Addict & Mental Hlth, Res Imaging Ctr, MRI Unit, Toronto, ON M5T 1R8, Canada.
   [Chavez, Sofia; Voineskos, Aristotle N.; Chakravarty, M. Mallar] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Schira, Mark M.] Univ Wollongong, Sch Psychol, Wollongong, NSW, Australia.
   [Schira, Mark M.] Neurosci Res Australia, Sydney, NSW, Australia.
   [Lobaugh, Nancy J.] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada.
   [Lerch, Jason P.] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada.
   [Lerch, Jason P.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.
   [Chakravarty, M. Mallar] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada.
RP Park, MTM (reprint author), Ctr Addict & Mental Hlth, Res Imaging Ctr, Kimel Family Translat Imaging Genet Res Lab, 250 Coll St, Toronto, ON M5T 1R8, Canada.
EM mtpark89@gmail.com; mallar.chakravarty@camh.ca
FU CAMH Foundation; W. Garfield Weston Foundation; Canadian Institutes of
   Health Research; Ontario Mental Health Foundation; NARSAD; National
   Institute of Mental Health [R01MH099167]; Canada Foundation for
   Innovation under the Compute Canada; Government of Ontario; Ontario
   Research Fund - Research Excellence; University of Toronto
FX We wish to thank Anusha Ravichandran for help with image acquisition,
   and we acknowledge support from the CAMH Foundation, thanks to Michael
   and Sonja Koerner, the Kimel Family, and the Paul E. Garfinkel New
   Investigator Catalyst Award. MMC is funded by the W. Garfield Weston
   Foundation and ANV is funded by the Canadian Institutes of Health
   Research, Ontario Mental Health Foundation, NARSAD, and the National
   Institute of Mental Health (R01MH099167). Computations were performed on
   the GPC supercomputer at the SciNet HPC Consortium. SciNet is funded by:
   the Canada Foundation for Innovation under the auspices of Compute
   Canada; the Government of Ontario; Ontario Research Fund - Research
   Excellence; and the University of Toronto.
CR Allen G, 1997, SCIENCE, V275, P1940, DOI 10.1126/science.275.5308.1940
   Andreasen NC, 1995, NEUROIMAGE, V2, P296, DOI 10.1006/nimg.1995.1037
   Andreasen NC, 1999, HUM BRAIN MAPP, V8, P226, DOI 10.1002/(SICI)1097-0193(1999)8:4<226::AID-HBM6>3.0.CO;2-4
   Avants BB, 2008, MED IMAGE ANAL, V12, P26, DOI 10.1016/j.media.2007.06.004
   Baldacara L, 2011, J AFFECT DISORDERS, V135, P305, DOI 10.1016/j.jad.2011.06.059
   Bastian AJ, 2006, CURR OPIN NEUROBIOL, V16, P645, DOI 10.1016/j.conb.2006.08.016
   Bastian AJ, 1998, ANN NEUROL, V44, P601, DOI 10.1002/ana.410440405
   Bogovic J.A., 2013, 23 C INF PROC MED IM
   Bogovic JA, 2013, NEUROIMAGE, V64, P616, DOI 10.1016/j.neuroimage.2012.08.075
   Buckner RL, 2011, J NEUROPHYSIOL, V106, P2322, DOI 10.1152/jn.00339.2011
   Chakravarty MM, 2013, HUM BRAIN MAPP, V34, P2635, DOI 10.1002/hbm.22092
   Chakravarty MM, 2009, HUM BRAIN MAPP, V30, P3574, DOI 10.1002/hbm.20780
   Chakravarty MM, 2008, MED IMAGE ANAL, V12, P713, DOI 10.1016/j.media.2008.04.003
   Chen J., 2010, MOL NEURODEGENER, V20, P60
   Collins DL, 2010, NEUROIMAGE, V52, P1355, DOI 10.1016/j.neuroimage.2010.04.193
   COLLINS DL, 1994, J COMPUT ASSIST TOMO, V18, P192
   COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
   Diedrichsen J, 2009, NEUROIMAGE, V46, P39, DOI 10.1016/j.neuroimage.2009.01.045
   Diedrichsen J, 2006, NEUROIMAGE, V33, P127, DOI 10.1016/j.neuroimage.2006.05.056
   Eskildsen SF, 2012, NEUROIMAGE, V59, P2362, DOI 10.1016/j.neuroimage.2011.09.012
   Fukutani Y, 1996, NEUROSCI LETT, V214, P33
   Habas C, 2009, J NEUROSCI, V29, P8586, DOI 10.1523/JNEUROSCI.1868-09.2009
   Habel U, 2005, NEUROIMAGE, V26, P206, DOI 10.1016/j.neuroimage.2005.01.014
   Hanson J.L., 2012, FRONT NEUROSCI
   Hartmann SL, 1999, IEEE T MED IMAGING, V18, P917, DOI 10.1109/42.811273
   Heckemann RA, 2006, NEUROIMAGE, V33, P115, DOI 10.1016/j.neuroimage.2006.05.061
   Holmes CJ, 1998, J COMPUT ASSIST TOMO, V22, P324, DOI 10.1097/00004728-199803000-00032
   Hutchinson S, 2003, CEREB CORTEX, V13, P943, DOI 10.1093/cercor/13.9.943
   Hwang J, 2011, MAGN RESON IMAGING, V29, P1014, DOI 10.1016/j.mri.2011.01.005
   Ichimiya T, 2001, BIOL PSYCHIAT, V49, P20, DOI 10.1016/S0006-3223(00)01081-7
   Isambert A, 2008, RADIOTHER ONCOL, V87, P93, DOI 10.1016/j.radonc.2007.11.030
   Jacobsen LK, 1997, AM J PSYCHIAT, V154, P1663
   James AC, 2004, AM J PSYCHIAT, V161, P1023, DOI 10.1176/appi.ajp.161.6.1023
   Kibby MY, 2008, J CHILD NEUROL, V23, P368, DOI 10.1177/08883073807309235
   KIM SG, 1994, SCIENCE, V265, P949, DOI 10.1126/science.8052851
   Klein A, 2009, NEUROIMAGE, V46, P786, DOI 10.1016/j.neuroimage.2008.12.037
   van der Lijn F, 2012, IEEE T MED IMAGING, V31, P276, DOI 10.1109/TMI.2011.2168420
   Krienen FM, 2009, CEREB CORTEX, V19, P2485, DOI 10.1093/cercor/bhp135
   Levitt JJ, 1999, AM J PSYCHIAT, V156, P1105
   Loeber RT, 2001, AM J PSYCHIAT, V158, P952, DOI 10.1176/appi.ajp.158.987.952
   Luft AR, 1998, MAGNET RESON MED, V40, P143, DOI 10.1002/mrm.1910400119
   MIDDLETON FA, 1994, SCIENCE, V266, P458, DOI 10.1126/science.7939688
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Mottolese C, 2013, BRAIN, V136, P330, DOI 10.1093/brain/aws186
   Muller RA, 2001, BIOL PSYCHIAT, V49, P665, DOI 10.1016/S0006-3223(00)01004-0
   MURAKAMI JW, 1989, ARCH NEUROL-CHICAGO, V46, P689
   Nenadic I, 2010, NEUROIMAGE, V49, P1153, DOI 10.1016/j.neuroimage.2009.10.014
   Nopoulos PC, 1999, BIOL PSYCHIAT, V46, P703, DOI 10.1016/S0006-3223(99)00093-1
   O'Halloran CJ, 2012, J CLIN EXP NEUROPSYC, V34, P35, DOI 10.1080/13803395.2011.614599
   Okugawa G, 2002, SCHIZOPHR RES, V55, P61, DOI 10.1016/S0920-9964(01)00248-1
   O'Reilly JX, 2010, CEREB CORTEX, V20, P953, DOI 10.1093/cercor/bhp157
   Petersen S E, 1989, J Cogn Neurosci, V1, P153, DOI 10.1162/jocn.1989.1.2.153
   Pierson R, 2002, NEUROIMAGE, V17, P61, DOI 10.1006/nimg.2002.1207
   Pipitone J, 2014, NEUROIMAGE
   PIVEN J, 1992, BIOL PSYCHIAT, V31, P491, DOI 10.1016/0006-3223(92)90260-7
   Powell S, 2008, NEUROIMAGE, V39, P238, DOI 10.1016/j.neuroimage.2007.05.063
   Riva D, 2000, BRAIN, V123, P1051, DOI 10.1093/brain/123.5.1051
   Freund Y., 1995, Computational Learning Theory. Second European Conference, EuroCOLT '95. Proceedings
   Schlerf JE, 2010, J NEUROPHYSIOL, V103, P3330, DOI 10.1152/jn.01117.2009
   Schmahmann J. D., 2000, MRI ATLAS HUMAN CERE
   Schmahmann JD, 1998, BRAIN, V121, P561, DOI 10.1093/brain/121.4.561
   Schmahmann JD, 1999, NEUROIMAGE, V10, P233, DOI 10.1006/nimg.1999.0459
   SCHMAHMANN JD, 1991, ARCH NEUROL-CHICAGO, V48, P1178
   Schmahmann JD, 2004, J NEUROPSYCH CLIN N, V16, P367, DOI 10.1176/appi.neuropsych.16.3.367
   Schmahmann JD, 2007, CEREBELLUM, V6, P254, DOI 10.1080/14734220701490995
   Sled JG, 1998, IEEE T MED IMAGING, V17, P87, DOI 10.1109/42.668698
   Stoodley CJ, 2012, CEREBELLUM, V11, P352, DOI 10.1007/s12311-011-0260-7
   Stoodley CJ, 2009, NEUROIMAGE, V44, P489, DOI 10.1016/j.neuroimage.2008.08.039
   Strick PL, 2009, ANNU REV NEUROSCI, V32, P413, DOI 10.1146/annurev.neuro.31.060407.125606
   Thach W. T., 1996, Behavioral and Brain Sciences, V19, P411
   THACH WT, 1992, ANNU REV NEUROSCI, V15, P403, DOI 10.1146/annurev.neuro.15.1.403
   Thomann PA, 2008, J PSYCHIATR RES, V42, P1198, DOI 10.1016/j.jpsychires.2007.12.002
   Turner BM, 2007, NEUROPSYCHOLOGIA, V45, P1331, DOI 10.1016/j.neuropsychologia.2006.09.023
   Wang HZ, 2011, NEUROIMAGE, V55, P968, DOI 10.1016/j.neuroimage.2011.01.006
   Warfield SK, 2004, IEEE T MED IMAGING, V23, P903, DOI 10.1109/TMI.2004.828354
   Wegiel J, 1999, BRAIN RES, V818, P41, DOI 10.1016/S0006-8993(98)01279-7
   Winterburn JL, 2013, NEUROIMAGE, V74, P254, DOI 10.1016/j.neuroimage.2013.02.003
   Wang HZ, 2013, FRONT NEUROINFORM, V7, DOI 10.3389/fninf.2013.00027
   Zhao L, 2010, MED IMAGE ANAL, V14, P360, DOI 10.1016/j.media.2010.02.001
NR 79
TC 6
Z9 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
EI 1095-9572
J9 NEUROIMAGE
JI Neuroimage
PD JUL 15
PY 2014
VL 95
BP 217
EP 231
DI 10.1016/j.neuroimage.2014.03.037
PG 15
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA AI9QN
UT WOS:000337267900021
PM 24657354
ER

PT J
AU Faust, M
   Kenett, YN
AF Faust, Miriam
   Kenett, Yoed N.
TI Rigidity, chaos and integration: hemispheric interaction and individual
   differences in metaphor comprehension
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE metaphors; creative language; cerebral hemispheres; network science;
   chaos; rigidity; integration
ID HIGH-FUNCTIONING AUTISM; SMALL-WORLD NETWORKS; SEMANTIC NETWORKS;
   CEREBRAL HEMISPHERES; ASPERGERS SYNDROME; BRAIN; LANGUAGE;
   SCHIZOPHRENIA; CREATIVITY; DYNAMICS
AB Neurotypical individuals cope flexibly with the full range of semantic relations expressed in human language, including metaphoric relations. This impressive semantic ability may be associated with distinct and flexible patterns of hemispheric interaction, including higher right hemisphere (RH) involvement for processing novel metaphors. However this ability may be impaired in specific clinical conditions, such as Asperger syndrome (AS) and schizophrenia. The impaired semantic processing is accompanied by different patterns of hemispheric interaction during semantic processing, showing either reduced (in Asperger syndrome) or excessive (in schizophrenia) RH involvement. This paper interprets these individual differences using the terms Rigidity Chaos and Integration, which describe patterns of semantic memory network states that either lead to semantic well-being or are disruptive of it. We argue that these semantic network states lie on a rigidity-chaos semantic continuum. We define these terms via network science terminology and provide network, cognitive and neural evidence to support our claim. This continuum includes left hemisphere (LH) hyper rigid semantic memory state on one end (e g., in persons with AS), and RH chaotic and over-flexible semantic memory state on the other end (e.g., in persons with schizophrenia). In between these two extremes lie different states of semantic memory structure which are related to individual differences in semantic creativity. We suggest that efficient semantic processing is achieved by semantic integration, a balance between semantic rigidity and semantic chaos. Such integration is achieved via intra-hemispheric communication. However, impairments to this well-balanced and integrated pattern of hemispheric interaction, e.g., when one hemisphere dominates the other, may lead to either semantic rigidity or semantic chaos, moving away from semantic integration and thus impairing the processing of metaphoric language.
C1 [Faust, Miriam; Kenett, Yoed N.] Bar Ilan Univ, Leslie & Susan Gonda Goldschmied Multidisciplinar, IL-52900 Ramat Gan, Israel.
   [Faust, Miriam] Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
RP Faust, M (reprint author), Bar Ilan Univ, Leslie & Susan Gonda Goldschmied Multidisciplinar, Bldg 901, IL-52900 Ramat Gan, Israel.
EM faustm@mail.biu.ac.il
FU Israel Science Foundation (ISF) [724/09]; I-CORE Program of the Planning
   and Budgeting Committee
FX We thank Dror Kenett for his helpful remarks on this manuscript. This
   research was supported by the Israel Science Foundation (ISF) grant
   (number 724/09) to Miriam Faust and partially supported by the I-CORE
   Program of the Planning and Budgeting Committee.
CR Alexander-Bloch Aaron F, 2010, Front Syst Neurosci, V4, P147, DOI 10.3389/fnsys.2010.00147
   Arenas A., 2012, INT J BIFURCAT CHAOS, V22, DOI [10.1142/s021812741250157x, DOI 10.1142/S021812741250157X]
   Aziz-Zadeh L, 2013, SOC COGN AFFECT NEUR, V8, P475, DOI 10.1093/scan/nss021
   Baronchelli A, 2013, TRENDS COGN SCI, V17, P348, DOI 10.1016/j.tics.2013.04.010
   Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
   Beckage N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019348
   Benedek M, 2013, J CREATIVE BEHAV, V47, P273, DOI 10.1002/jocb.35
   Boccaletti S, 2006, PHYS REP, V424, P175, DOI 10.1016/j.physrep.2005.10.009
   Boersma M, 2011, HUM BRAIN MAPP, V32, P413, DOI 10.1002/hbm.21030
   Boger-Megiddo I, 2006, J AUTISM DEV DISORD, V36, P733, DOI 10.1007/s10803-006-0121-2
   Bohrn IC, 2012, NEUROPSYCHOLOGIA, V50, P2669, DOI 10.1016/j.neuropsychologia.2012.07.021
   Borge-Holthoefer J, 2010, ENTROPY-SWITZ, V12, P1264, DOI 10.3390/e12051264
   Bowden EM, 2003, PSYCHON B REV, V10, P730, DOI 10.3758/BF03196539
   Bowdle BF, 2005, PSYCHOL REV, V112, P193, DOI 10.1037/0033-295X.112.1.193
   BROWNELL HH, 1983, BRAIN LANG, V18, P20, DOI 10.1016/0093-934X(83)90002-0
   Bullmore ET, 2012, NAT REV NEUROSCI, V13, P336, DOI 10.1038/nrn3214
   BURGESS C, 1988, BRAIN LANG, V33, P86, DOI 10.1016/0093-934X(88)90056-9
   Caeyenberghs K, 2014, HUM BRAIN MAPP, V35, P4944, DOI 10.1002/hbm.22524
   Chan KY, 2010, COGNITIVE SCI, V34, P685, DOI 10.1111/j.1551-6709.2010.01100.x
   Chiarello C, 2003, MIND, BRAIN, AND LANGUAGE: MULTIDISCIPLINARY PERSPECTIVES, P229
   Cohen R., 2010, COMPLEX NETWORKS STR
   COLLINS AM, 1969, J VERB LEARN VERB BE, V8, P240, DOI 10.1016/S0022-5371(69)80069-1
   De Deyne S, 2008, BEHAV RES METHODS, V40, P198, DOI 10.3758/BRM.40.1.198
   de Bie HMA, 2012, HUM BRAIN MAPP, V33, P1189, DOI 10.1002/hbm.21280
   De Deyne S, 2008, BEHAV RES METHODS, V40, P213, DOI 10.3758/BRM.40.1.213
   Diaz MT, 2011, J COGNITIVE NEUROSCI, V23, P3586, DOI 10.1162/jocn_a_00053
   Diaz MT, 2011, NEUROPSYCHOLOGIA, V49, P320, DOI 10.1016/j.neuropsychologia.2010.12.004
   Erdos P., 1960, PUBL MATH I HUNG, V5, P17
   Fan Y, 2011, NEUROIMAGE, V54, P1862, DOI 10.1016/j.neuroimage.2010.07.025
   Faust M., 2012, ADV NEURAL SUBSTRATE, P425
   Faust M, 2002, NEUROPSYCHOLOGIA, V40, P892, DOI 10.1016/S0028-3932(01)00174-9
   Faust M, 2003, COGNITIVE BRAIN RES, V17, P585, DOI 10.1016/S0926-6410(03)00172-1
   Faust M, 1998, NEUROPSYCHOLOGIA, V36, P827, DOI 10.1016/S0028-3932(98)00042-6
   Fortunato S, 2010, PHYS REP, V486, P75, DOI 10.1016/j.physrep.2009.11.002
   Gernsbacher MA, 2012, METAPHOR SYMBOL, V27, P93, DOI 10.1080/10926488.2012.656255
   GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x
   Glucksberg Samuel, 2001, UNDERSTANDING FIGURA
   Gold R, 2012, METAPHOR SYMBOL, V27, P55, DOI 10.1080/10926488.2012.638826
   Gold R, 2010, BRAIN LANG, V113, P124, DOI [10.1016/j.bandl.2010.03.002, 10.1016/j.band1.2010.03.002]
   Gold R, 2011, LATERALITY, V17, P602, DOI DOI 10.1080/1357650X.2011.599936
   Gold R, 2010, J AUTISM DEV DISORD, V40, P800, DOI 10.1007/s10803-009-0930-1
   Jung-Beeman M, 2005, TRENDS COGN SCI, V9, P512, DOI 10.1016/j.tics.2005.09.009
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kenett DY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015032
   Kenett YN, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00543
   Kenett YN, 2014, FRONT HUM NEUROSCI, V8, DOI 10.3389/fnhum.2014.00407
   Kenett YN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023912
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Lakoff G., 1980, METAPHORS WE LIVE BY
   Le Sourn-Bissaoui S, 2011, RES AUTISM SPECT DIS, V5, P648, DOI 10.1016/j.rasd.2010.07.012
   Liu Y, 2008, BRAIN, V131, P945, DOI 10.1093/brain/awn018
   Lynall ME, 2010, J NEUROSCI, V30, P9477, DOI 10.1523/JNEUROSCI.0333-10.2010
   Martin I, 2004, J AUTISM DEV DISORD, V34, P311, DOI 10.1023/B:JADD.0000029553.52889.15
   Mashal N, 2005, NEUROPSYCHOLOGIA, V43, P2084, DOI 10.1016/j.neuropsychologia.2005.03.019
   McAlonan GM, 2009, PSYCHOL MED, V39, P1885, DOI 10.1017/S0033291709005728
   MEDNICK SA, 1962, PSYCHOL REV, V69, P220, DOI 10.1037/h0048850
   Meunier David, 2010, Front Neurosci, V4, P200, DOI 10.3389/fnins.2010.00200
   Micheloyannis S, 2006, SCHIZOPHR RES, V87, P60, DOI 10.1016/j.schres.2006.06.028
   Mihov KM, 2010, BRAIN COGNITION, V72, P442, DOI 10.1016/j.bandc.2009.12.007
   Milgram S., 1967, PSYCHOL TODAY, P62
   Mirous H. J., 2012, HDB NEUROPSYCHOLOGY, P319, DOI DOI 10.1002/9781118432501.CH16
   Mota NB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034928
   Newman M.E.J., 2010, NETWORKS INTRO
   Newman MEJ, 2006, P NATL ACAD SCI USA, V103, P8577, DOI 10.1073/pnas.0601602103
   Nijstad BA, 2010, EUR REV SOC PSYCHOL, V21, P34, DOI 10.1080/10463281003765323
   Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
   Pobric G., 2007, J COGNITIVE NEUROSCI, V20, P170, DOI [10.1162/jocn.2008.20.1.170, DOI 10.1162/JOCN.2008.20.1.170]
   Rapp A. M., 2012, ADV NEURAL SUBSTRATE, P406
   Rapp AM, 2012, NEUROIMAGE, V63, P600, DOI 10.1016/j.neuroimage.2012.06.022
   Razoumnikova O M, 2000, Brain Res Cogn Brain Res, V10, P11
   Razumnikova OM, 2007, BRAIN RES BULL, V73, P96, DOI 10.1016/j.brainresbull.2007.02.008
   Rogers TT, 2008, CAMB HANDB PSYCHOL, P226
   Rossmann E, 2010, PERS INDIV DIFFER, V49, P891, DOI 10.1016/j.paid.2010.07.025
   Rubinov M, 2009, HUM BRAIN MAPP, V30, P403, DOI 10.1002/hbm.20517
   Runco MA, 2012, CREATIVITY RES J, V24, P92, DOI 10.1080/10400419.2012.650092
   Schilling MA, 2005, CREATIVITY RES J, V17, P131, DOI 10.1207/s15326934crj1702&3_2
   Schmidt GL, 2009, BRAIN COGNITION, V71, P375, DOI 10.1016/j.bandc.2009.06.001
   Shai S., 2014, RESILIENCE MODULAR C
   Siegel D. J., 2010, MINDSIGHT NEW SCI PE
   Smit DJA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036896
   Sporns O, 2011, FRONT COMPUT NEUROSC, V5, DOI 10.3389/fncom.2011.00005
   Sternberg RJ, 1999, HDB CREAT, V1, P3
   Steyvers M, 2005, COGNITIVE SCI, V29, P41, DOI 10.1207/s15516709cog2901_3
   Takeuchi H, 2010, NEUROIMAGE, V51, P11, DOI 10.1016/j.neuroimage.2010.02.035
   Takeuchi H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025532
   Thoma P, 2006, NEUROSCI BIOBEHAV R, V30, P1182, DOI 10.1016/j.neubiorev.2006.09.001
   van Straaten ECW, 2013, EUR NEUROPSYCHOPHARM, V23, P7, DOI 10.1016/j.euroneuro.2012.10.010
   Vitevitch MS, 2014, COGNITIVE PSYCHOL, V68, P1, DOI 10.1016/j.cogpsych.2013.10.002
   Vitevitch MS, 2008, J SPEECH LANG HEAR R, V51, P408, DOI 10.1044/1092-4388(2008/030)
   Vitevitch MS, 2012, J MEM LANG, V67, P30, DOI 10.1016/j.jml.2012.02.008
   Voorspoels W, 2014, CORTEX, V55, P130, DOI 10.1016/j.cortex.2013.09.006
   Watts DJ, 1998, NATURE, V393, P440, DOI 10.1038/30918
   Williams DL, 2013, AUTISM RES, V6, P288, DOI 10.1002/aur.1291
   Yang FG, 2009, BRAIN LANG, V111, P114, DOI 10.1016/j.bandl.2009.08.006
   Yang J, 2014, HUM BRAIN MAPP, V35, P107, DOI 10.1002/hbm.22160
   Yap PT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024678
   Yovel G, 2008, NEUROPSYCHOLOGIA, V46, P3061, DOI 10.1016/j.neuropsychologia.2008.06.017
   Zeev-Wolf M, 2014, NEUROPSYCHOLOGIA, V56, P119, DOI 10.1016/j.neuropsychologia.2014.01.008
   Zhao Q, 2014, NEUROSCIENCE, V256, P334, DOI 10.1016/j.neuroscience.2013.10.019
NR 100
TC 2
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JUL 14
PY 2014
VL 8
AR 511
DI 10.3389/fnhum.2014.00511
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AM7QQ
UT WOS:000340063100001
PM 25071534
ER

PT J
AU Marnetto, D
   Molineris, I
   Grassi, E
   Provero, P
AF Marnetto, Davide
   Molineris, Ivan
   Grassi, Elena
   Provero, Paolo
TI Genome-wide Identification and Characterization of Fixed Human-Specific
   Regulatory Regions
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID SEMANTIC SIMILARITY; GO TERMS; EVOLUTION; EXPRESSION; ELEMENTS; DNA;
   STICKLEBACKS; HYPOTHESIS; DISORDERS; FOREBRAIN
AB Changes in gene regulatory networks are believed to have played an important role in the development of human-specific anatomy and behavior. We identified the human genome regions that show the typical chromatin marks of regulatory regions but cannot be aligned to other mammalian genomes. Most of these regions have become fixed in the human genome. Their regulatory targets are enriched in genes involved in neural processes, CNS development, and diseases such as autism, depression, and schizophrenia. Specific transposable elements contributing to the rewiring of the human regulatory network can be identified by the creation of human-specific regulatory regions. Our results confirm the relevance of regulatory evolution in the emergence of human traits and cognitive abilities and the importance of newly acquired genomic elements for such evolution.
C1 [Marnetto, Davide; Molineris, Ivan; Grassi, Elena; Provero, Paolo] Univ Turin, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy.
   [Provero, Paolo] Ist Sci San Raffaele, Ctr Translat Genom & Bioinformat, I-20132 Milan, Italy.
RP Provero, P (reprint author), Univ Turin, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy.
EM paolo.provero@unito.it
CR Altshuler DM, 2012, NATURE, V491, P56, DOI 10.1038/nature11632
   Bailey JA, 2000, P NATL ACAD SCI USA, V97, P6634, DOI 10.1073/pnas.97.12.6634
   Bernstein BE, 2010, NAT BIOTECHNOL, V28, P1045, DOI 10.1038/nbt1010-1045
   Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
   Brawand D, 2011, NATURE, V478, P343, DOI 10.1038/nature10532
   Carroll SB, 2005, PLOS BIOL, V3, P1159, DOI 10.1371/journal.pbio.0030245
   Chan YF, 2010, SCIENCE, V327, P302, DOI 10.1126/science.1182213
   Defossez PA, 2005, J BIOL CHEM, V280, P43017, DOI 10.1074/jbc.M510802200
   Donaldson IJ, 2006, GENOME BIOL, V7, DOI 10.1186/gb-2006-7-6-r52
   Ernst J, 2011, NATURE, V473, P43, DOI 10.1038/nature09906
   Falcon S, 2007, BIOINFORMATICS, V23, P257, DOI 10.1093/bioinformatics/btl567
   Gentleman RC, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-10-r80
   Green Phil, 2013, Science, V340, P682, DOI 10.1126/science.1233195
   Haygood R, 2007, NAT GENET, V39, P1140, DOI 10.1038/ng2104
   Hernando-Herraez I, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003763
   Ip BK, 2011, CEREB CORTEX, V21, P1395, DOI 10.1093/cercor/bhq219
   Iwamoto K, 2009, RNA BIOL, V6, P248
   KING MC, 1975, SCIENCE, V188, P107, DOI 10.1126/science.1090005
   Levin HL, 2011, NAT REV GENET, V12, P615, DOI 10.1038/nrg3030
   Maurano MT, 2012, SCIENCE, V337, P1190, DOI 10.1126/science.1222794
   McLean CY, 2010, NAT BIOTECHNOL, V28, P495, DOI 10.1038/nbt.1630
   Miller CT, 2007, CELL, V131, P1179, DOI 10.1016/j.cell.2007.10.055
   Molineris I, 2011, MOL BIOL EVOL, V28, P2173, DOI 10.1093/molbev/msr027
   Peter IS, 2011, CELL, V144, P970, DOI 10.1016/j.cell.2011.02.017
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Quinlan AR, 2010, BIOINFORMATICS, V26, P841, DOI 10.1093/bioinformatics/btq033
   Rebeiz M, 2011, P NATL ACAD SCI USA, V108, P10036, DOI 10.1073/pnas.1105937108
   Reinchisi G, 2012, CEREB CORTEX, V22, P2820, DOI 10.1093/cercor/bhr359
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Schmidt D, 2012, CELL, V148, P335, DOI 10.1016/j.cell.2011.11.058
   Schriml LM, 2012, NUCLEIC ACIDS RES, V40, pD940, DOI 10.1093/nar/gkr972
   Shibata Y, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002789
   TAJIMA F, 1989, GENETICS, V123, P585
   Tishkoff SA, 2007, NAT GENET, V39, P31, DOI 10.1038/ng1946
   Torgerson DG, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000592
   Tripodi M, 2004, DEVELOPMENT, V131, P6119, DOI 10.1242/dev.01530
   Wang JZ, 2007, BIOINFORMATICS, V23, P1274, DOI 10.1093/bioinformatics/btm087
   Ward LD, 2012, SCIENCE, V337, P1675, DOI 10.1126/science.1225057
   Ward Lucas D, 2013, Science, V340, P682, DOI 10.1126/science.1233366
   Wray GA, 2007, NAT REV GENET, V8, P206, DOI 10.1038/nrg2063
   Xie W, 2013, CELL, V153, P1134, DOI 10.1016/j.cell.2013.04.022
   Yu GC, 2010, BIOINFORMATICS, V26, P976, DOI 10.1093/bioinformatics/btq064
   Feng JX, 2012, NAT PROTOC, V7, P1728, DOI 10.1038/nprot.2012.101
NR 43
TC 1
Z9 1
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
EI 1537-6605
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD JUL 13
PY 2014
VL 95
IS 1
BP 39
EP 48
DI 10.1016/j.ajhg.2014.05.011
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA AL1RP
UT WOS:000338904100003
PM 24995867
ER

PT J
AU Liang, MK
   Zhong, J
   Liu, HX
   Lopatina, O
   Nakada, R
   Yamauchi, AM
   Higashida, H
AF Liang, Mingkun
   Zhong, Jing
   Liu, Hong-Xiang
   Lopatina, Olga
   Nakada, Ryusuke
   Yamauchi, Agnes-Mikiko
   Higashida, Haruhiro
TI Pairmate-dependent pup retrieval as parental behavior in male mice
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE parental behavior; paternal care; pup retrieval behavior; paternity;
   mouse
ID MEDIAL PREOPTIC AREA; AUTISM SPECTRUM DISORDER; BRAIN OXYTOCIN
   SECRETION; PATERNAL BEHAVIOR; MATERNAL-BEHAVIOR;
   PEROMYSCUS-CALIFORNICUS; NUCLEUS-ACCUMBENS; VENTRAL PALLIDUM; BIPARENTAL
   CARE; SOCIAL-BEHAVIOR
AB Appropriate parental care by fathers can greatly facilitate healthy human family life. However, much less is known about paternal behavior in animals compared to those regarding maternal behavior. Previously, we reported that male ICR strain laboratory mice, although not spontaneously parental, can be induced to display maternal-like parental care (pup retrieval) when separated from their pups by signals from the pairmate dam (Liu et al., 2013). This parental behavior by the ICR sires, which are not genetically biparental, is novel and has been designated as pairmate-dependent paternal behavior. However, the factors critical for this paternal behavior are unclear. Here, we report that the pairmate-dependent paternal retrieval behavior is observed especially in the ICR strain and not in C57BL/6 or BALB/c mice. An ICR sire displays retrieval behavior only toward his biological pups. A sire co-housed with an unrelated non-pairing dam in a new environment, under which 38-kHz ultrasonic vocalizations are not detected, does not show parenting behavior. It is important for sires to establish their own home territory (cage) by continuous housing and testing to display retrieval behavior. These results indicated that the ICR sires display distinct paternity, including father-child social interaction, and shed light on parental behavior, although further analyses of paternal care at the neuroendocrinological and neurocircuitry levels are required.
C1 [Liang, Mingkun; Zhong, Jing; Liu, Hong-Xiang; Lopatina, Olga; Higashida, Haruhiro] Kanazawa Univ, Res Ctr Child Mental Dev, Dept Basic Res Social Recognit & Memory, Kanazawa, Ishikawa 9208640, Japan.
   [Liang, Mingkun; Zhong, Jing; Nakada, Ryusuke; Yamauchi, Agnes-Mikiko] Kanazawa Univ, Grad Sch Med Sci, Dept Biophys Genet, Kanazawa, Ishikawa 9208640, Japan.
RP Higashida, H (reprint author), Kanazawa Univ, Res Ctr Child Mental Dev, Dept Basic Res Social Recognit & Memory, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan.
EM haruhiro@med.kanazawa-u.ac.jp
FU Core Research for Evolutional Science and Technology (CREST) from the
   Japan Science and Technology Agency; Strategic Research Program for
   Brain Sciences from Ministry of Education, Culture, Sports, Science, and
   Technology, Japan
FX This work was supported in part by the Core Research for Evolutional
   Science and Technology (CREST) from the Japan Science and Technology
   Agency and by the Strategic Research Program for Brain Sciences from
   Ministry of Education, Culture, Sports, Science, and Technology, Japan.
CR Ahern TH, 2011, DEV PSYCHOBIOL, V53, P118, DOI 10.1002/dev.20498
   Akther S, 2014, NEUROSCI LETT, V570, P21, DOI 10.1016/j.neulet.2014.03.078
   Akther S, 2013, MOL BRAIN, V6, DOI 10.1186/1756-6606-6-41
   Amato PR, 2005, FUTURE CHILD, V15, P75, DOI 10.1353/foc.2005.0012
   Bambico F. R., 2013, CEREB CORTEX, DOI [10.1093/cercor/bht310, DOI 10.1093/CERCOR/BHT310]
   Benbassat N, 2012, J ADOLESCENCE, V35, P163, DOI 10.1016/j.adolescence.2011.03.004
   Bornovalova MA, 2014, PSYCHOL MED, V44, P831, DOI 10.1017/S0033291713001086
   Bridges R., 2008, NEUROBIOLOGY PARENTA, P1, DOI [10.1016/B978-012374285-8.00037-8, DOI 10.1016/B978-012374285-8.00037-8]
   Carter CS, 2009, DEV NEUROSCI-BASEL, V31, P332, DOI 10.1159/000216544
   Chourbaji S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019218
   de Jong TR, 2009, HORM BEHAV, V56, P220, DOI 10.1016/j.yhbeh.2009.05.001
   Douglas AJ, 2011, PROG NEURO-PSYCHOPH, V35, P1167, DOI 10.1016/j.pnpbp.2010.07.024
   Feinberg M. E., 2002, PSYCHOL REV, V5, P173, DOI [10.1023/A:1019695015110, DOI 10.1023/A:1019695015110]
   Feldman R, 2012, BIOL PSYCHIAT, V72, P175, DOI 10.1016/j.biopsych.2011.12.025
   Fleming AS, 2002, PHARMACOL BIOCHEM BE, V73, P61, DOI 10.1016/S0091-3057(02)00793-1
   Fortunato L, 2010, J EVOLUTION BIOL, V23, P149, DOI 10.1111/j.1420-9101.2009.01884.x
   Fujimoto H, 2013, NEUROSCI LETT, V546, P63, DOI 10.1016/j.neulet.2013.04.059
   Gammie Stephen C, 2005, Behav Cogn Neurosci Rev, V4, P119, DOI 10.1177/1534582305281086
   GUBERNICK DJ, 1987, J COMP PSYCHOL, V101, P169, DOI 10.1037/0735-7036.101.2.169
   GUBERNICK DJ, 1989, ANIM BEHAV, V37, P656, DOI 10.1016/0003-3472(89)90044-4
   Hager R, 2003, NATURE, V421, P533, DOI 10.1038/nature01239
   Hashimoto Hirofumi, 2012, Pathophysiology, V19, P283, DOI 10.1016/j.pathophys.2012.07.005
   Higashida H, 2012, NEUROCHEM INT, V61, P828, DOI 10.1016/j.neuint.2012.01.030
   Higashida H, 2012, HORM BEHAV, V61, P351, DOI 10.1016/j.yhbeh.2011.12.011
   Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
   Jin D, 2007, NATURE, V446, P41, DOI 10.1038/nature05526
   Kalueff AV, 2007, BEHAV BRAIN RES, V177, P45, DOI 10.1016/j.bbr.2006.11.005
   Kentner AC, 2010, NEUROSCI BIOBEHAV R, V34, P438, DOI 10.1016/j.neubiorev.2009.08.010
   Kuroda KO, 2011, PROG NEURO-PSYCHOPH, V35, P1205, DOI 10.1016/j.pnpbp.2011.02.008
   Kuroda KO, 2007, MOL CELL NEUROSCI, V36, P121, DOI 10.1016/j.mcn.2007.05.010
   Lambert KG, 2013, NEUROSCIENCE, V234, P1, DOI 10.1016/j.neuroscience.2012.12.023
   Lee AW, 2007, PHYSIOL BEHAV, V92, P617, DOI 10.1016/j.physbeh.2007.05.008
   Lee HJ, 2009, PROG NEUROBIOL, V88, P127, DOI 10.1016/j.pneurobio.2009.04.001
   Leuner B, 2010, TRENDS NEUROSCI, V33, P465, DOI 10.1016/j.tins.2010.07.003
   Liu HX, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2336
   Liu HX, 2008, NEUROSCI LETT, V448, P67, DOI 10.1016/j.neulet.2008.09.084
   Lonstein JS, 2000, NEUROSCI BIOBEHAV R, V24, P669, DOI 10.1016/S0149-7634(00)00036-1
   McGraw LA, 2010, TRENDS NEUROSCI, V33, P103, DOI 10.1016/j.tins.2009.11.006
   Mogi K, 2011, PROG NEURO-PSYCHOPH, V35, P1232, DOI 10.1016/j.pnpbp.2010.08.024
   Morgan CP, 2011, J NEUROSCI, V31, P11748, DOI 10.1523/JNEUROSCI.1887-11.2011
   Morrison KE, 2014, NEUROSCIENCE, V264, P17, DOI 10.1016/j.neuroscience.2013.11.014
   Morrongiello BA, 2013, ACCIDENT ANAL PREV, V54, P108, DOI 10.1016/j.aap.2013.02.005
   Munesue T, 2010, NEUROSCI RES, V67, P181, DOI 10.1016/j.neures.2010.03.004
   Neumann ID, 2009, FRONT NEUROENDOCRIN, V30, P483, DOI 10.1016/j.yfrne.2009.04.012
   Nishimori K, 2008, PROG BRAIN RES, V170, P79, DOI 10.1016/S0079-6123(08)00408-1
   Numan M, 2009, FRONT NEUROENDOCRIN, V30, P46, DOI 10.1016/j.yfrne.2008.10.002
   Numan M, 2005, BEHAV BRAIN RES, V158, P53, DOI 10.1016/j.bbr.2004.08.008
   Nunes S, 2001, HORM BEHAV, V39, P70, DOI 10.1006/hbeh.2000.1631
   Ogawa S, 1998, ENDOCRINOLOGY, V139, P5058, DOI 10.1210/en.139.12.5058
   Ozawa M, 2010, J VET MED SCI, V72, P1589, DOI 10.1292/jvms.10-0173
   Parhar I, 2012, PROG NEUROBIOL, V98, P176, DOI 10.1016/j.pneurobio.2012.05.011
   Pfaff D W, 1999, Results Probl Cell Differ, V26, P91
   Reburn CJ, 1999, HORM BEHAV, V35, P163, DOI 10.1006/hbeh.1998.1509
   Riebold M, 2011, MOL MED, V17, P799, DOI 10.2119/molmed.2011.00080
   ROSENBLA.JS, 1967, SCIENCE, V156, P1512, DOI 10.1126/science.156.3781.1512
   Rosenblatt JS, 1996, HORM BEHAV, V30, P201, DOI 10.1006/hbeh.1996.0025
   Salmina AB, 2013, CURR TOP MED CHEM, V13, P2965
   Saltzman W, 2011, PROG NEURO-PSYCHOPH, V35, P1192, DOI 10.1016/j.pnpbp.2010.09.017
   Schor EL, 2003, PEDIATRICS, V111, P1541
   Soga T, 2012, NEUROSCIENCE, V218, P56, DOI 10.1016/j.neuroscience.2012.05.023
   Tachikawa KS, 2013, J NEUROSCI, V33, P5120, DOI 10.1523/JNEUROSCI.2364-12.2013
   Wright SL, 2000, J COMP PSYCHOL, V114, P183, DOI 10.1037//0735-7036.114.2.183
   Wu Z, 2014, NATURE, V509, P325, DOI 10.1038/nature13307
   Wynne-Edwards KE, 2007, HORM BEHAV, V52, P114, DOI 10.1016/j.yhbeh.2007.03.018
   Yoshida S, 2013, FRONT ZOOL, V10, DOI 10.1186/1742-9994-10-50
NR 65
TC 0
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JUL 11
PY 2014
VL 8
AR 186
DI 10.3389/fnins.2014.00186
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AW8GE
UT WOS:000346498400001
PM 25071431
ER

PT J
AU Bacchelli, E
   Ceroni, F
   Pinto, D
   Lomartire, S
   Giannandrea, M
   D'Adamo, P
   Bonora, E
   Parchi, P
   Tancredi, R
   Battaglia, A
   Maestrini, E
AF Bacchelli, Elena
   Ceroni, Fabiola
   Pinto, Dalila
   Lomartire, Silvia
   Giannandrea, Maila
   D'Adamo, Patrizia
   Bonora, Elena
   Parchi, Piero
   Tancredi, Raffaella
   Battaglia, Agatino
   Maestrini, Elena
TI A CTNNA3 compound heterozygous deletion implicates a role for alpha
   T-catenin in susceptibility to autism spectrum disorder
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder (ASD); CTNNA3; alpha T-catenin; Alpha
   T-catenin; Cell adhesion; DNA copy number variants
ID ONSET ALZHEIMERS-DISEASE; REPEAT TRANSMEMBRANE PROTEINS; GENOME-WIDE
   ASSOCIATION; COPY NUMBER VARIATIONS; COMMON FRAGILE SITES; RARE DE-NOVO;
   CELL-ADHESION; GENES; EXPRESSION; VARIANTS
AB Background: Autism spectrum disorder (ASD) is a highly heritable, neurodevelopmental condition showing extreme genetic heterogeneity. While it is well established that rare genetic variation, both de novo and inherited, plays an important role in ASD risk, recent studies also support a rare recessive contribution.
   Methods: We identified a compound heterozygous deletion intersecting the CTNNA3 gene, encoding alpha T-catenin, in a proband with ASD and moderate intellectual disability. The deletion breakpoints were mapped at base-pair resolution, and segregation analysis was performed. We compared the frequency of CTNNA3 exonic deletions in 2,147 ASD cases from the Autism Genome Project (AGP) study versus the frequency in 6,639 controls. Western blot analysis was performed to get a quantitative characterisation of Ctnna3 expression during early brain development in mouse.
   Results: The CTNNA3 compound heterozygous deletion includes a coding exon, leading to a putative frameshift and premature stop codon. Segregation analysis in the family showed that the unaffected sister is heterozygote for the deletion, having only inherited the paternal deletion. While the frequency of CTNNA3 exonic deletions is not significantly different between ASD cases and controls, no homozygous or compound heterozygous exonic deletions were found in a sample of over 6,000 controls. Expression analysis of Ctnna3 in the mouse cortex and hippocampus (P0-P90) provided support for its role in the early stage of brain development.
   Conclusion: The finding of a rare compound heterozygous CTNNA3 exonic deletion segregating with ASD, the absence of CTNNA3 homozygous exonic deletions in controls and the high expression of Ctnna3 in both brain areas analysed implicate CTNNA3 in ASD susceptibility.
C1 [Bacchelli, Elena; Ceroni, Fabiola; Lomartire, Silvia; Maestrini, Elena] Univ Bologna, Dept Pharm & Biotechnol, I-40126 Bologna, Italy.
   [Pinto, Dalila] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
   [Pinto, Dalila] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Pinto, Dalila] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
   [Pinto, Dalila] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
   [Giannandrea, Maila; D'Adamo, Patrizia] Ist Sci San Raffaele, Div Neurosci, Dulbecco Telethon Inst, I-20132 Milan, Italy.
   [D'Adamo, Patrizia] Univ Vita Salute San Raffaele, I-20132 Milan, Italy.
   [Bonora, Elena] Univ Bologna, S Orsola Malpighi Hosp, Dept Med & Surg Sci, Unit Med Genet, I-40138 Bologna, Italy.
   [Parchi, Piero] IRCCS Inst Neurol Sci, I-40139 Bologna, Italy.
   [Parchi, Piero] Univ Bologna, Dept Biomed & Neuromotor Sci, I-40139 Bologna, Italy.
   [Tancredi, Raffaella; Battaglia, Agatino] Stella Maris Clin Res Inst Child & Adolescent Neu, I-56128 Pisa, Italy.
RP Maestrini, E (reprint author), Univ Bologna, Dept Pharm & Biotechnol, Via Selmi 3, I-40126 Bologna, Italy.
EM elena.maestrini@unibo.it
FU University of Bologna (RFO)
FX We gratefully acknowledge all the families who have participated in the
   study, the professionals who made this study possible and the
   international Autism Genome Project (AGP) Consortium for sharing
   pre-publication CTNNA3 CNV data and controls and for advice. We wish to
   thank Jolanda van Hengel for providing the anti-alpha T-catenin
   polyclonal antibody. Funding for this work comes from the University of
   Bologna (RFO).
CR Abe K, 2004, NAT NEUROSCI, V7, P357, DOI 10.1038/nn1212
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   [Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
   Betancur C, 2009, TRENDS NEUROSCI, V32, P402, DOI 10.1016/j.tins.2009.04.003
   Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Busby V, 2004, NEUROMOL MED, V5, P133, DOI 10.1385/NMM:5:2:133
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Dillon LW, 2013, HUM MOL GENET, V22, P1443, DOI 10.1093/hmg/dds561
   Ertekin-Taner N, 2000, SCIENCE, V290, P2303, DOI 10.1126/science.290.5500.2303
   Ertekin-Taner N, 2003, HUM MOL GENET, V12, P3133, DOI 10.1093/hmg/ddg343
   Figueiredo JC, 2011, CANCER EPIDEM BIOMAR, V20, P758, DOI 10.1158/1055-9965.EPI-10-0675
   Fox CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002695
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
   Goossens S, 2007, J CELL SCI, V120, P2126, DOI 10.1242/jcs.004713
   HIRANO S, 1992, CELL, V70, P293, DOI 10.1016/0092-8674(92)90103-J
   Janssens B, 2001, J CELL SCI, V114, P3177
   Kalkman HO, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-10
   Krawczak M, 2006, COMMUNITY GENET, V9, P55, DOI 10.1159/000090694
   Lauren J, 2003, GENOMICS, V81, P411, DOI 10.1016/S0888-7543(03)00030-2
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Li JF, 2012, J CELL SCI, V125, P1058, DOI 10.1242/jcs.098640
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   Linhoff MW, 2009, NEURON, V61, P734, DOI 10.1016/j.neuron.2009.01.017
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Majercak J, 2006, P NATL ACAD SCI USA, V103, P17967, DOI 10.1073/pnas.0605461103
   Martin ER, 2005, J MED GENET, V42, P787, DOI 10.1136/jmg.2004.029553
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   NAGAFUCHI A, 1991, CELL, V65, P849, DOI 10.1016/0092-8674(91)90392-C
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Pinto D, 2014, AM J HUM GENET, V94, P677, DOI 10.1016/j.ajhg.2014.03.018
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Prasad A, 2012, G3-GENES GENOM GENET, V2, P1665, DOI 10.1534/g3.112.004689
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Savelyeva L, 2006, CANCER LETT, V232, P58, DOI 10.1016/j.canlet.2005.08.033
   Shaikh TH, 2009, GENOME RES, V19, P1682, DOI 10.1101/gr.083501.108
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Smith CL, 2010, CURR GENOMICS, V11, P447, DOI 10.2174/138920210793176001
   Smith DI, 2006, CANCER LETT, V232, P48, DOI 10.1016/j.canlet.2005.06.049
   Soler-Llavina GJ, 2011, P NATL ACAD SCI USA, V108, P16502, DOI 10.1073/pnas.1114028108
   Sousa I, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-7
   Stewart AFR, 2009, J AM COLL CARDIOL, V53, P1471, DOI 10.1016/j.jacc.2008.12.051
   Uvarov P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089910
   van Dijk M, 2004, GENE EXPR PATTERNS, V5, P61, DOI 10.1016/j.modgep.2004.06.006
   Vissers LELM, 2009, HUM MOL GENET, V18, P3579, DOI 10.1093/hmg/ddp306
   Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Ye HH, 2010, NEUROSIGNALS, V18, P62, DOI 10.1159/000322543
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
NR 55
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUL 10
PY 2014
VL 6
AR 17
DI 10.1186/1866-1955-6-17
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AL6CG
UT WOS:000339219200001
PM 25050139
ER

PT J
AU Poliakov, E
   Koonin, EV
   Rogozin, IB
AF Poliakov, Eugenia
   Koonin, Eugene V.
   Rogozin, Igor B.
TI Impairment of translation in neurons as a putative causative factor for
   autism
SO BIOLOGY DIRECT
LA English
DT Article
DE Synonymous mutations; Single nucleotide polymorphism; Codon usage;
   Splicing enhancer; Splicing silencer; mRNA secondary structure;
   Transcription factor binding; Neurotoxin
ID EXONIC SPLICING ENHANCERS; SYNONYMOUS CODON USAGE; HAZARDOUS
   AIR-POLLUTANTS; RNA SECONDARY STRUCTURE; DE-NOVO MUTATIONS; SPECTRUM
   DISORDERS; MOLECULAR CHAPERONES; PURIFYING SELECTION;
   HUNTINGTONS-DISEASE; POSITIVE SELECTION
AB Background: A dramatic increase in the prevalence of autism and Autistic Spectrum Disorders (ASD) has been observed over the last two decades in USA, Europe and Asia. Given the accumulating data on the possible role of translation in the etiology of ASD, we analyzed potential effects of rare synonymous substitutions associated with ASD on mRNA stability, splicing enhancers and silencers, and codon usage.
   Presentation of the hypothesis: We hypothesize that subtle impairment of translation, resulting in dosage imbalance of neuron-specific proteins, contributes to the etiology of ASD synergistically with environmental neurotoxins.
   Testing the hypothesis: A statistically significant shift from optimal to suboptimal codons caused by rare synonymous substitutions associated with ASD was detected whereas no effect on other analyzed characteristics of transcripts was identified. This result suggests that the impact of rare codons on the translation of genes involved in neuron development, even if slight in magnitude, could contribute to the pathogenesis of ASD in the presence of an aggressive chemical background. This hypothesis could be tested by further analysis of ASD-associated mutations, direct biochemical characterization of their effects, and assessment of in vivo effects on animal models.
C1 [Poliakov, Eugenia] NEI, Retinal Cell & Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
   [Koonin, Eugene V.; Rogozin, Igor B.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
RP Koonin, EV (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
EM koonin@ncbi.nlm.nih.gov; rogozin@ncbi.nlm.nih.gov
FU Intramural Research Program of the National Eye Institute; Intramural
   Research Program of the National Library of Medicine at the National
   Institutes of Health (US Department Health and Human Services)
FX This work was supported by the by the Intramural Research Program of the
   National Eye Institute and the Intramural Research Program of the
   National Library of Medicine at the National Institutes of Health (US
   Department Health and Human Services).
CR Arguello PA, 2012, TRENDS NEUROSCI, V35, P3, DOI 10.1016/j.tins.2011.11.007
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Ayoub MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032849
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Barrett MJ, 2004, J NEUROSCI RES, V78, P420, DOI 10.1002/jnr.20249
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Betterton EA, 2003, CRIT REV ENV SCI TEC, V33, P423, DOI 10.1080/1064338039245002
   Bishop DVM, 2008, DEV MED CHILD NEUROL, V50, P341, DOI 10.1111/j.1469-8749.2008.02057.x
   Blencowe BJ, 2000, TRENDS BIOCHEM SCI, V25, P106, DOI 10.1016/S0968-0004(00)01549-8
   Brown V, 2001, CELL, V107, P477, DOI 10.1016/S0092-8674(01)00568-2
   Buchan JR, 2007, BIOL CELL, V99, P475, DOI 10.1042/BC20070037
   Buizer-Voskamp JE, 2010, EUR J HUM GENET, V18, P588, DOI 10.1038/ejhg.2009.206
   Calvo PL, 2014, AM J TRANSPLANT, V14, P960, DOI 10.1111/ajt.12645
   Ceman S, 2003, HUM MOL GENET, V12, P3295, DOI 10.1093/hmg/ddg350
   Chamary JV, 2006, NAT REV GENET, V7, P98, DOI 10.1038/nrg1770
   Chow ML, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002592
   Christensen J, 2013, JAMA-J AM MED ASSOC, V309, P1696, DOI 10.1001/jama.2013.2270
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   DeSoto MC, 2009, NEUROTOXICOLOGY, V30, P331, DOI 10.1016/j.neuro.2009.03.003
   Deth R, 2008, NEUROTOXICOLOGY, V29, P190, DOI 10.1016/j.neuro.2007.09.010
   Dewey CN, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-311
   Drake JW, 1998, GENETICS, V148, P1667
   Duffy FH, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-64
   Duret L, 2002, CURR OPIN GENET DEV, V12, P640, DOI 10.1016/S0959-437X(02)00353-2
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   El-Ansary AK, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-74
   El-Fishawy P, 2010, PSYCHIAT CLIN N AM, V33, P83, DOI 10.1016/j.psc.2009.12.002
   Fairbrother WG, 2002, SCIENCE, V297, P1007, DOI 10.1126/science.1073774
   Fairbrother WG, 2004, PLOS BIOL, V2, P1388, DOI 10.1371/journal.pbio.0020268
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Frydman J, 2001, ANNU REV BIOCHEM, V70, P603, DOI 10.1146/annurev.biochem.70.1.603
   Garrecht M, 2011, TOXICOL ENVIRON CHEM, V93, P1251, DOI 10.1080/02772248.2011.580588
   Ghosh A, 2013, NAT REV DRUG DISCOV, V12, P777, DOI 10.1038/nrd4102
   Graber TE, 2013, P NATL ACAD SCI USA, V110, P16205, DOI 10.1073/pnas.1307747110
   Grandjean P, 2014, LANCET NEUROL, V13, P330, DOI 10.1016/S1474-4422(13)70278-3
   Greenberg DA, 2001, AM J HUM GENET, V69, P1062, DOI 10.1086/324191
   Grether JK, 2009, J AUTISM DEV DISORD, V39, P1412, DOI 10.1007/s10803-009-0754-z
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harigaya Y, 2010, WIRES RNA, V1, P132, DOI 10.1002/wrna.17
   Harrison Charlotte, 2012, Nat Rev Drug Discov, V11, P440, DOI 10.1038/nrd3761
   Hartl FU, 2002, SCIENCE, V295, P1852, DOI 10.1126/science.1068408
   Hasday JD, 2000, CELL STRESS CHAPERON, V5, P471, DOI 10.1379/1466-1268(2000)005<0471:FATHSR>2.0.CO;2
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
   Hurst LD, 2001, TRENDS GENET, V17, P62, DOI 10.1016/S0168-9525(00)02173-9
   Hussman JP, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-1
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76
   Ke SD, 2008, GENOME RES, V18, P533, DOI 10.1101/gr.070268.107
   Kelleher RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035003
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Khromov-Borisov NN, 1999, MUTAT RES-FUND MOL M, V430, P55, DOI 10.1016/S0027-5107(99)00148-7
   Kimchi-Sarfaty C, 2007, SCIENCE, V315, P525, DOI 10.1126/science.1135308
   Kimura M., 1983, NEUTRAL THEORY MOL E
   King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
   Kirkbride JB, 2011, PLOS ONE, V7
   Kondrashov AS, 2003, HUM MUTAT, V21, P12, DOI 10.1002/humu.10147
   Lada AG, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003736
   Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
   Leary SC, 2002, J BIOL CHEM, V277, P11321, DOI 10.1074/jbc.M112303200
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Marinova Z, 2009, J NEUROCHEM, V111, P976, DOI 10.1111/j.1471-4159.2009.06385.x
   MARTIN W, 1988, BRIT J PHARMACOL, V93, P229
   McFarland CD, 2013, P NATL ACAD SCI USA, V110, P2910, DOI 10.1073/pnas.1213968110
   Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
   Morgan JT, 2012, BRAIN RES, V1456, P72, DOI 10.1016/j.brainres.2012.03.036
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Roak BJ, 2012, NAT GENET, V43, P585
   Ogurtsov AY, 2006, BIOINFORMATICS, V22, P1317, DOI 10.1093/bioinformatics/bt/083
   Parmley JL, 2006, MOL BIOL EVOL, V23, P301, DOI 10.1093/molbev/msj035
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Petrovski S, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003709
   Plotkin JB, 2011, NAT REV GENET, V12, P32, DOI 10.1038/nrg2899
   Plotkin JB, 2004, P NATL ACAD SCI USA, V101, P12588, DOI 10.1073/pnas.0404957101
   Pringsheim T, 2012, MOVEMENT DISORD, V27, P1083, DOI 10.1002/mds.25075
   Rachidi M, 2007, NEUROSCI RES, V59, P349, DOI 10.1016/j.neures.2007.08.007
   Rajdev S, 2000, TOXICOL PATHOL, V28, P105, DOI 10.1177/019262330002800113
   Ramos-Arroyo MA, 2005, J NEUROL NEUROSUR PS, V76, P337, DOI 10.1136/jnnp.2004.036806
   Resch AM, 2007, MOL BIOL EVOL, V24, P1821, DOI 10.1093/molbev/msm100
   RITVO ER, 1985, AM J PSYCHIAT, V142, P187
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Rogozin IB, 2003, MUTAT RES-REV MUTAT, V544, P65, DOI 10.1016/S1383-5742(03)00032-2
   Rossignol DA, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.4
   Roullet FI, 2013, NEUROTOXICOL TERATOL, V36, P47, DOI 10.1016/j.ntt.2013.01.004
   Rzhetsky A, 2014, PLOS COMPUT BIOL, V10, DOI 10.1371/journal.pcbi.1003518
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sauna ZE, 2011, NAT REV GENET, V12, P683, DOI 10.1038/nrg3051
   Schaal TD, 1999, MOL CELL BIOL, V19, P1705
   Scotet V, 2012, ORPHANET J RARE DIS, V7, DOI 10.1186/1750-1172-7-14
   Semon M, 2006, MOL BIOL EVOL, V23, P523, DOI 10.1093/molbev/msj053
   Shabalina SA, 2006, NUCLEIC ACIDS RES, V34, P2428, DOI 10.1093/nar/gkl287
   SHARP PM, 1987, NUCLEIC ACIDS RES, V15, P1281, DOI 10.1093/nar/15.3.1281
   Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
   Silverman JL, 2012, SCI TRANSL MED, V4
   SMALLEY SL, 1988, ARCH GEN PSYCHIAT, V45, P953
   Spooren W, 2012, TRENDS PHARMACOL SCI, V33, P669, DOI 10.1016/j.tips.2012.09.004
   Stamatoyannopoulos JA, 2009, NAT GENET, V41, P393, DOI 10.1038/ng.363
   STANNARD JN, 1948, J BIOL CHEM, V172, P599
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Stenson PD, 2014, HUM GENET, V133, P1, DOI 10.1007/s00439-013-1358-4
   Stergachis AB, 2013, SCIENCE, V342, P1367, DOI 10.1126/science.1243490
   Stonebraker JS, 2010, HAEMOPHILIA, V16, P20, DOI 10.1111/j.1365-2516.2009.02127.x
   Stoner R, 2014, NEW ENGL J MED, V370, P1209, DOI 10.1056/NEJMoa1307491
   Terekhanova NV, 2013, MOL BIOL EVOL, V30, P1315, DOI 10.1093/molbev/mst036
   Thomas RH, 2010, J NEUROCHEM, V113, P515, DOI 10.1111/j.1471-4159.2010.06614.x
   Tsai CJ, 2008, J MOL BIOL, V383, P281, DOI 10.1016/j.jmb.2008.08.012
   Urrutia AO, 2001, GENETICS, V159, P1191
   Veitia RA, 2010, J PATHOL, V220, P174, DOI 10.1002/path.2623
   Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835
   Waldman YY, 2010, NUCLEIC ACIDS RES, V38, P2964, DOI 10.1093/nar/gkq009
   Waldman YY, 2011, GENOME BIOL EVOL, V3, P749, DOI 10.1093/gbe/evr076
   Warrington JA, 2000, PHYSIOL GENOMICS, V2, P143
   Willie E, 2004, TRENDS GENET, V20, P534, DOI 10.1016/j.tig.2004.08.014
   Willmund F, 2013, CELL, V152, P196, DOI 10.1016/j.cell.2012.12.001
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Wingate M, 2014, MMWR SURVEILL SUMM, V63, P1
   Wingate M., 2012, MMWR SURVEILL SUMM, V61, P1
   Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
   Yau V, 2013, CLIN MED RES, V11, P166
   Zerbo O, 2013, J AUTISM DEV DISORD, V43, P25, DOI 10.1007/s10803-012-1540-x
   Zuker M, 2003, NUCLEIC ACIDS RES, V31, P3406, DOI 10.1093/nar/gkg595
NR 124
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6150
J9 BIOL DIRECT
JI Biol. Direct
PD JUL 10
PY 2014
VL 9
AR 16
DI 10.1186/1745-6150-9-16
PG 13
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AL3GX
UT WOS:000339016000001
PM 25011470
ER

PT J
AU Agam, Y
   Vangel, M
   Roffman, JL
   Gallagher, PJ
   Chaponis, J
   Haddad, S
   Goff, DC
   Greenberg, JL
   Wilhelm, S
   Smoller, JW
   Manoach, DS
AF Agam, Yigal
   Vangel, Mark
   Roffman, Joshua L.
   Gallagher, Patience J.
   Chaponis, Jonathan
   Haddad, Stephen
   Goff, Donald C.
   Greenberg, Jennifer L.
   Wilhelm, Sabine
   Smoller, Jordan W.
   Manoach, Dara S.
TI Dissociable Genetic Contributions to Error Processing: A Multimodal
   Neuroimaging Study
SO PLOS ONE
LA English
DT Article
ID EVENT-RELATED FMRI; OBSESSIVE COMPULSIVE SCALE; DOPAMINE-D4 RECEPTOR
   GENE; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX;
   METHYLENETETRAHYDROFOLATE REDUCTASE; ANTERIOR CINGULATE;
   PARKINSONS-DISEASE; HEALTHY-VOLUNTEERS; PREFRONTAL CORTEX
AB Background: Neuroimaging studies reliably identify two markers of error commission: the error-related negativity (ERN), an event-related potential, and functional MRI activation of the dorsal anterior cingulate cortex (dACC). While theorized to reflect the same neural process, recent evidence suggests that the ERN arises from the posterior cingulate cortex not the dACC. Here, we tested the hypothesis that these two error markers also have different genetic mediation.
   Methods: We measured both error markers in a sample of 92 comprised of healthy individuals and those with diagnoses of schizophrenia, obsessive-compulsive disorder or autism spectrum disorder. Participants performed the same task during functional MRI and simultaneously acquired magnetoencephalography and electroencephalography. We examined the mediation of the error markers by two single nucleotide polymorphisms: dopamine D4 receptor (DRD4) C-521T (rs1800955), which has been associated with the ERN and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133), which has been associated with error-related dACC activation. We then compared the effects of each polymorphism on the two error markers modeled as a bivariate response.
   Results: We replicated our previous report of a posterior cingulate source of the ERN in healthy participants in the schizophrenia and obsessive-compulsive disorder groups. The effect of genotype on error markers did not differ significantly by diagnostic group. DRD4 C-521T allele load had a significant linear effect on ERN amplitude, but not on dACC activation, and this difference was significant. MTHFR C677T allele load had a significant linear effect on dACC activation but not ERN amplitude, but the difference in effects on the two error markers was not significant.
   Conclusions: DRD4 C-521T, but not MTHFR C677T, had a significant differential effect on two canonical error markers. Together with the anatomical dissociation between the ERN and error-related dACC activation, these findings suggest that these error markers have different neural and genetic mediation.
C1 [Agam, Yigal; Roffman, Joshua L.; Goff, Donald C.; Greenberg, Jennifer L.; Wilhelm, Sabine; Smoller, Jordan W.; Manoach, Dara S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Agam, Yigal; Vangel, Mark; Manoach, Dara S.] Harvard Univ, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
   [Gallagher, Patience J.; Chaponis, Jonathan; Haddad, Stephen; Smoller, Jordan W.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Human Genet Res, Boston, MA USA.
RP Manoach, DS (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
EM dara@nmr.mgh.harvard.edu
FU NIH [F32 MH088081, K24MH094614, R01 MH67720]
FX This work was supported in part by NIH grants F32 MH088081 (YA);
   K24MH094614 (JWS); and R01 MH67720 (DSM). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Agam Y, 2011, P NATL ACAD SCI USA, V108, P17556, DOI 10.1073/pnas.1103475108
   Allen NC, 2008, NAT GENET, V40, P827, DOI 10.1038/ng.171
   Althaus M, 2010, BIOL PSYCHOL, V85, P19, DOI 10.1016/j.biopsycho.2010.04.007
   Althaus M, 2009, CLIN NEUROPHYSIOL, V120, P93, DOI 10.1016/j.clinph.2008.10.012
   Anokhin AP, 2008, PSYCHOPHYSIOLOGY, V45, P524, DOI 10.1111/j.1469-8986.2008.00664.x
   Belopolsky AV, 2006, BRAIN RES, V1081, P171, DOI 10.1016/j.brainres.2006.01.082
   BERGER B, 1988, J COMP NEUROL, V273, P99, DOI 10.1002/cne.902730109
   Biehl SC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028396
   Buckner RL, 1998, NEURON, V20, P285, DOI 10.1016/S0896-6273(00)80456-0
   Burock MA, 2000, HUM BRAIN MAPP, V11, P249, DOI 10.1002/1097-0193(200012)11:4<249::AID-HBM20>3.0.CO;2-5
   COLLINS DL, 1994, J COMPUT ASSIST TOMO, V18, P192
   Cox RW, 1999, MAGNET RESON MED, V42, P1014, DOI 10.1002/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO;2-F
   Dale AM, 1999, HUM BRAIN MAPP, V8, P109, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<109::AID-HBM7>3.0.CO;2-W
   Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
   de Bruijn ERA, 2006, BRAIN RES, V1105, P122, DOI 10.1016/j.brainres.2006.01.006
   de Bruijn ERA, 2004, PSYCHOPHARMACOLOGY, V177, P151, DOI 10.1007/s00213-004-1915-6
   Desikan RS, 2006, NEUROIMAGE, V31, P968, DOI 10.1016/j.neuroimage.2006.01.021
   Endrass T, 2007, EUR J NEUROSCI, V26, P1714, DOI 10.1111/j.1460-9568.2007.05785.x
   Endrass T, 2005, J PSYCHOPHYSIOL, V19, P275, DOI 10.1027/0269-8803.19.4.275
   Falkenstein M, 2001, NEUROREPORT, V12, P157, DOI 10.1097/00001756-200101220-00039
   Fassbender C, 2004, COGNITIVE BRAIN RES, V20, P132, DOI 10.1016/j.cogbrainres.2004.02.007
   First M, 2002, STRUCTURED CLIN INTE
   First M.B., 1997, STRUCTURED CLIN INTE
   Fischl B, 2004, CEREB CORTEX, V14, P11, DOI 10.1093/cercor/bhg087
   Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
   Frank MJ, 2007, COGN AFFECT BEHAV NE, V7, P297, DOI 10.3758/CABN.7.4.297
   Friso S, 2002, P NATL ACAD SCI USA, V99, P5606, DOI 10.1073/pnas.062066299
   FROSST P, 1995, NAT GENET, V10, P111, DOI 10.1038/ng0595-111
   GOLDMANRAKIC PS, 1989, P NATL ACAD SCI USA, V86, P9015, DOI 10.1073/pnas.86.22.9015
   GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
   GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012
   HAMALAINEN M, 1993, REV MOD PHYS, V65, P413, DOI 10.1103/RevModPhys.65.413
   Hamalainen M, 1984, TKKFA559 U TECHN DEP
   Heilbronner SR, 2013, NEURON, V80, P1384, DOI 10.1016/j.neuron.2013.09.028
   Holroyd CB, 2002, PSYCHOL REV, V109, P679, DOI 10.1037//0033-295X.109.4.679
   Ito J, 2006, J GERIATR PSYCH NEUR, V19, P46, DOI 10.1177/0891988705284716
   Kereszturi E, 2006, BMC MOL BIOL, V7, DOI 10.1186/1471-2199-7-18
   Klein TA, 2007, NEUROIMAGE, V34, P1774, DOI 10.1016/j.neuroimage.2006.11.014
   Kramer UM, 2007, J NEUROSCI, V27, P14190, DOI 10.1523/JNEUROSCI.4229-07.2007
   Kriegeskorte N, 2009, NAT NEUROSCI, V12, P535, DOI 10.1038/nn.2303
   Lin FH, 2006, HUM BRAIN MAPP, V27, P1, DOI 10.1002/hbm.20155
   LOFTUS GR, 1994, PSYCHON B REV, V1, P476, DOI 10.3758/BF03210951
   Logothetis NK, 2008, NATURE, V453, P869, DOI 10.1038/nature06976
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Magno E, 2006, J NEUROSCI, V26, P4769, DOI 10.1523/JNEUROSCI.0369-06.2006
   Manoach DS, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00350
   Meyer A, 2012, GENES BRAIN BEHAV, V11, P695, DOI 10.1111/j.1601-183X.2012.00812.x
   Miezin FM, 2000, NEUROIMAGE, V11, P735, DOI 10.1006/nimg.2000.0568
   Miller MW, 2009, CINGULATE NEUROBIOLO, P163
   Modirrousta M, 2008, J NEUROSCI, V28, P14000, DOI 10.1523/JNEUROSCI.4450-08.2008
   Nieuwenhuis S, 2001, PSYCHOPHYSIOLOGY, V38, P752, DOI 10.1017/S0048577201001111
   Okuyama Y, 1999, BIOCHEM BIOPH RES CO, V258, P292, DOI 10.1006/bbrc.1999.0630
   Osinsky R, 2012, BRAIN RES, V1452, P108, DOI 10.1016/j.brainres.2012.02.054
   Polli FE, 2005, P NATL ACAD SCI USA, V102, P15700, DOI 10.1073/pnas.0503657102
   Purcell S, 2007, AM J HUM GENET, P81
   Ridderinkhof KR, 2004, SCIENCE, V306, P443, DOI 10.1126/science.1100301
   Roffman JL, 2011, BRAIN IMAGING BEHAV, V5, P65, DOI 10.1007/s11682-010-9111-2
   Roffman JL, 2007, SCHIZOPHR RES, V92, P181, DOI 10.1016/j.schres.2007.01.003
   Roffman JL, 2008, P NATL ACAD SCI USA, V105, P17573, DOI 10.1073/pnas.0803727105
   Roffman JL, 2008, AM J MED GENET B
   Roffman JL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025253
   Roffman JL, 2008, BIOL PSYCHIAT, V63, P42, DOI 10.1016/j.biopsych.2006.12.017
   Rubinstein M, 1997, CELL, V90, P991, DOI 10.1016/S0092-8674(00)80365-7
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Schmahmann JD, 2007, BRAIN, V130, P630, DOI 10.1093/brain/awl359
   Seamans JK, 2004, PROG NEUROBIOL, V74, P1, DOI 10.1016/j.pneurobio.2004.05.006
   Taulu S, 2005, J APPL PHYS, V97
   Taylor SF, 2007, NEUROSCIENTIST, V13, P160, DOI 10.1177/1073858406298184
   Thesen S, 2000, MAGNET RESON MED, V44, P457, DOI 10.1002/1522-2594(200009)44:3<457::AID-MRM17>3.0.CO;2-R
   Willemssen R, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004898
   Williams ZM, 2004, NAT NEUROSCI, V7, P1370, DOI 10.1038/nn1354
   Wittfoth M, 2008, BRAIN RES, V1194, P118, DOI 10.1016/j.brainres.2007.11.067
   Xing QH, 2003, SCHIZOPHR RES, V65, P9, DOI 10.1016/S0920-9964(03)00064-1
   Zirnheld PJ, 2004, J COGNITIVE NEUROSCI, V16, P1098, DOI 10.1162/0898929041502779
NR 74
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 10
PY 2014
VL 9
IS 7
AR e101784
DI 10.1371/journal.pone.0101784
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK9RG
UT WOS:000338763800038
PM 25010186
ER

PT J
AU Budday, S
   Raybaud, C
   Kuhl, E
AF Budday, Silvia
   Raybaud, Charles
   Kuhl, Ellen
TI A mechanical model predicts morphological abnormalities in the
   developing human brain
SO SCIENTIFIC REPORTS
LA English
DT Article
DE MECHANICAL ENGINEERING; COMPUTATIONAL BIOPHYSICS
ID SURFACE-BASED MORPHOMETRY; CEREBRAL-CORTEX; AXONAL ELONGATION; ADJOINING
   SULCI; GROWTH; SCHIZOPHRENIA; GYRIFICATION; TISSUES; GYRUS; MRI
AB The developing human brain remains one of the few unsolved mysteries of science. Advancements in developmental biology, neuroscience, and medical imaging have brought us closer than ever to understand brain development in health and disease. However, the precise role of mechanics throughout this process remains underestimated and poorly understood. Here we show that mechanical stretch plays a crucial role in brain development. Using the nonlinear field theories of mechanics supplemented by the theory of finite growth, we model the human brain as a living system with a morphogenetically growing outer surface and a stretch-driven growing inner core. This approach seamlessly integrates the two popular but competing hypotheses for cortical folding: axonal tension and differential growth. We calibrate our model using magnetic resonance images from very preterm neonates. Our model predicts that deviations in cortical growth and thickness induce morphological abnormalities. Using the gyrification index, the ratio between the total and exposed surface area, we demonstrate that these abnormalities agree with the classical pathologies of lissencephaly and polymicrogyria. Understanding the mechanisms of cortical folding in the developing human brain has direct implications in the diagnostics and treatment of neurological disorders, including epilepsy, schizophrenia, and autism.
C1 [Budday, Silvia; Kuhl, Ellen] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA.
   [Raybaud, Charles] Hosp Sick Children, Div Neuroradiol, Toronto, ON M5G 1X8, Canada.
   [Kuhl, Ellen] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.
RP Kuhl, E (reprint author), Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA.
EM ekuhl@stanford.edu
RI Kuhl, Ellen/G-4444-2011
OI Kuhl, Ellen/0000-0002-6283-935X
FU National Science Foundation CAREER Award [CMMI 0952021]; National
   Science Foundation INSPIRE Grant [1233054]; National Institutes of
   Health [U54 GM072970]
FX This work was supported by the National Science Foundation CAREER Award
   CMMI 0952021 and the INSPIRE Grant 1233054 and by the National
   Institutes of Health Grant U54 GM072970 to E.K.
CR Ambrosi D, 2011, J MECH PHYS SOLIDS, V59, P863, DOI 10.1016/j.jmps.2010.12.011
   Bayly PV, 2013, PHYS BIOL, V10, DOI 10.1088/1478-3975/10/1/016005
   Bayly PV, 2014, J MECH BEHAV BIOMED, V29, P568, DOI 10.1016/j.jmbbm.2013.02.018
   Ben Amar M, 2013, P NATL ACAD SCI USA, V110, P10525, DOI 10.1073/pnas.1217391110
   BRAY D, 1984, DEV BIOL, V102, P379, DOI 10.1016/0012-1606(84)90202-1
   Buganza Tepole Adrian, 2011, Journal of the Mechanics and Physics of Solids, V59, DOI 10.1016/j.jmps.2011.05.004
   Chada S, 1997, J CELL SCI, V110, P1179
   Chirat R, 2013, P NATL ACAD SCI USA, V110, P6015, DOI 10.1073/pnas.1220443110
   DENNERLL TJ, 1989, J CELL BIOL, V109, P3073, DOI 10.1083/jcb.109.6.3073
   Dunlop JWC, 2010, J MECH PHYS SOLIDS, V58, P1073, DOI 10.1016/j.jmps.2010.04.008
   Eskandari M, 2013, MATERIALS, V6, P5639, DOI 10.3390/ma6125639
   FERRER I, 1989, DEV BRAIN RES, V45, P303, DOI 10.1016/0165-3806(89)90049-7
   FERRER I, 1988, J ANAT, V160, P89
   Goriely A, 2005, PHYS REV LETT, V94, DOI 10.1103/PhysRevLett.94.198103
   Hager R., 2012, NATURE COMM, V3, P1038
   Hardan AY, 2004, PSYCHIAT RES-NEUROIM, V131, P263, DOI 10.1016/j.pscychresns.2004.06.001
   Harrington MJ, 2011, NAT COMMUN, V2, DOI 10.1038/ncomms1336
   Harris JM, 2004, BIOL PSYCHIAT, V55, P141, DOI 10.1016/S0006-3223(03)00789-3
   Harrison PJ, 1999, BRAIN, V122, P593, DOI 10.1093/brain/122.4.593
   Jin LH, 2011, EPL-EUROPHYS LETT, V95, DOI 10.1209/0295-5075/95/64002
   Jou RJ, 2005, SCHIZOPHR RES, V75, P309, DOI 10.1016/j.schres.2004.11.008
   Knutsen AK, 2013, CEREB CORTEX, V23, P488, DOI 10.1093/cercor/bhs042
   Kostovic I., SEM FET NEONAT MED, V11, P415
   Kuhl E, 2007, BIOMECH MODEL MECHAN, V6, P321, DOI 10.1007/s10237-006-0062-x
   Kuhl E, 2014, J MECH BEHAV BIOMED, V29, P529, DOI 10.1016/j.jmbbm.2013.10.009
   Landrieu P, 1998, NEURORADIOLOGY, V40, P173
   Li B, 2012, SOFT MATTER, V8, P5728, DOI 10.1039/c2sm00011c
   Li G, 2013, CEREB CORTEX, V23, P2724, DOI 10.1093/cercor/bhs265
   Luders E, 2008, CEREB CORTEX, V18, P2019, DOI 10.1093/cercor/bhm227
   MARINPAD.M, 1970, BRAIN RES, V23, P167, DOI 10.1016/0006-8993(70)90037-5
   Menzel A, 2012, MECH RES COMMUN, V42, P1, DOI 10.1016/j.mechrescom.2012.02.007
   Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
   Palaniyappan L, 2012, J PSYCHIATR NEUROSCI, V37, P399, DOI 10.1503/jpn.110119
   Papastavrou A, 2013, J MECH PHYS SOLIDS, V61, P1446, DOI 10.1016/j.jmps.2013.01.007
   Pfister BJ, 2004, J NEUROSCI, V24, P7978, DOI 10.1523/JNEUROSCI.1974-04.2004
   Raybaud C, 2013, NEURORADIOLOGY, V55, P23, DOI 10.1007/s00234-013-1231-0
   Raybaud C., 1996, DYSPLASIAS CEREBRAL
   Raybaud C, 2011, NEUROIMAG CLIN N AM, V21, P483, DOI 10.1016/j.nic.2011.05.014
   RICHMAN DP, 1975, SCIENCE, V189, P18
   RODRIGUEZ EK, 1994, J BIOMECH, V27, P455, DOI 10.1016/0021-9290(94)90021-3
   Ronan L, 2014, CEREB CORTEX, V24, P2219, DOI 10.1093/cercor/bht082
   Savin T, 2011, NATURE, V476, P57, DOI 10.1038/nature10277
   SMART IHM, 1986, J ANAT, V147, P27
   Smith DH, 2009, PROG NEUROBIOL, V89, P231, DOI 10.1016/j.pneurobio.2009.07.006
   Soza G, 2005, INT J MED ROBOT COMP, V1, P87, DOI 10.1002/rcs.32
   Suter DM, 2011, PROG NEUROBIOL, V94, P91, DOI 10.1016/j.pneurobio.2011.04.002
   Tortori-Donati P., 2005, PEDIAT NEURORADIOLOG, P71, DOI 10.1007/3-540-26398-5_4
   VanEssen DC, 1997, NATURE, V385, P313
   Weiss P., 1941, GROWTH             S, V5, P163
   Welker W., 1990, CEREBRAL CORTEX, V8B
   Wisco JJ, 2007, SCHIZOPHR RES, V94, P317, DOI 10.1016/j.schres.2007.03.031
   Xu G, 2010, J BIOMECH ENG-T ASME, V132, DOI 10.1115/1.4001683
   ZILLES K, 1988, ANAT EMBRYOL, V179, P173, DOI 10.1007/BF00304699
   Zollner AM, 2012, J THEOR BIOL, V297, P166, DOI 10.1016/j.jtbi.2011.12.022
NR 54
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 10
PY 2014
VL 4
AR 5644
DI 10.1038/srep05644
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK9RF
UT WOS:000338763700006
PM 25008163
ER

PT J
AU Karayannis, T
   Au, E
   Patel, JC
   Kruglikov, I
   Markx, S
   Delorme, R
   Heron, D
   Salomon, D
   Glessner, J
   Restituito, S
   Gordon, A
   Rodriguez-Murillo, L
   Roy, NC
   Gogos, JA
   Rudy, B
   Rice, ME
   Karayiorgou, M
   Hakonarson, H
   Keren, B
   Huguet, G
   Bourgeron, T
   Hoeffer, C
   Tsien, RW
   Peles, E
   Fishell, G
AF Karayannis, T.
   Au, E.
   Patel, J. C.
   Kruglikov, I.
   Markx, S.
   Delorme, R.
   Heron, D.
   Salomon, D.
   Glessner, J.
   Restituito, S.
   Gordon, A.
   Rodriguez-Murillo, L.
   Roy, N. C.
   Gogos, J. A.
   Rudy, B.
   Rice, M. E.
   Karayiorgou, M.
   Hakonarson, H.
   Keren, B.
   Huguet, G.
   Bourgeron, T.
   Hoeffer, C.
   Tsien, R. W.
   Peles, E.
   Fishell, G.
TI Cntnap4 differentially contributes to GABAergic and dopaminergic
   synaptic transmission
SO NATURE
LA English
DT Article
ID CORTICAL INTERNEURONS; GABA(A) RECEPTORS; PREPULSE INHIBITION;
   TOURETTES-SYNDROME; SCHIZOPHRENIA; SYNAPSES; NUMBER; ASSOCIATION;
   LINKAGE; RELEASE
AB Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and 2 (NRXN1 and NRXN2) and CNTNAP2 (also known as CASPR2), all members of the neurexin superfamily of transmembrane molecules, have been implicated in neuropsychiatric disorders. However, their loss leads to deficits that have been best characterized with regard to their effect on excitatory cells(1,2). Notably, other disease-associated genes such as BDNF and ERBB4 implicate specific interneuron synapses in psychiatric disorders(3,4). Consistent with this, cortical interneuron dysfunction has been linked to epilepsy, schizophrenia and autism(5,6). Using a microarray screen that focused upon synapse-associated molecules, we identified Cntnap4 (contactin associated protein-like 4, also known as Caspr4) as highly enriched in developing murine interneurons. In this study we show that Cntnap4 is localized presynaptically and its loss leads to a reduction in the output of cortical parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid producing) basket cells. Paradoxically, the loss of Cntnap4 augments midbrain dopaminergic release in the nucleus accumbens. In Cntnap4 mutant mice, synaptic defects in these disease-relevant neuronal populations are mirrored by sensory-motor gating and grooming endophenotypes; these symptoms could be pharmacologically reversed, providing promise for therapeutic intervention in psychiatric disorders.
C1 [Karayannis, T.; Au, E.; Kruglikov, I.; Restituito, S.; Roy, N. C.; Rudy, B.; Hoeffer, C.; Tsien, R. W.; Fishell, G.] NYU, Dept Neurosci & Physiol, Neurosci Inst, New York, NY 10016 USA.
   [Patel, J. C.; Rice, M. E.] NYU, Dept Neurosurg Neurosci & Physiol, Langone Med Ctr, New York, NY 10016 USA.
   [Markx, S.; Rodriguez-Murillo, L.; Karayiorgou, M.] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA.
   [Delorme, R.; Hakonarson, H.; Huguet, G.; Bourgeron, T.] Inst Pasteur, Human Genet & Cognit Funct Unit, F-75724 Paris, France.
   [Delorme, R.; Huguet, G.; Bourgeron, T.] Inst Pasteur, URA Genes Synapses & Cognit 2182, CNRS, F-75724 Paris, France.
   [Delorme, R.] Hop Robert Debre, AP HP, Dept Child & Adolescent Psychiat, F-75019 Paris, France.
   [Heron, D.] Grp Hosp Pitie Salpetriere, AP HP, Unite Fonct Genet Med, Dept Genet & Cytogenet,Ctr Reference,CRicm,UMR S9, F-75013 Paris, France.
   [Salomon, D.; Gordon, A.] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel.
   [Glessner, J.] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
   [Roy, N. C.] Natl Inst Deafness & Other Commun Disorders, Sect Synapt Transmiss, NIH, Bethesda, MD 20892 USA.
   [Gogos, J. A.] Columbia Univ, Med Ctr, Dept Physiol, New York, NY 10032 USA.
   [Gogos, J. A.] Columbia Univ, Med Ctr, Dept Cellular Biophys & Neurosci, New York, NY 10032 USA.
   [Keren, B.] Grp Hosp Pitie Salpetriere, AP HP, Unite Fonct Genet Chromosom, Dept Genet & Cytogenet,CRicm,UMR S975, F-75013 Paris, France.
   [Huguet, G.; Bourgeron, T.] Univ Paris Diderot, Sorbonne Paris Cite, F-75005 Paris, France.
   [Bourgeron, T.] FondaMental Fdn, F-94000 Creteil, France.
RP Fishell, G (reprint author), NYU, Dept Neurosci & Physiol, Neurosci Inst, New York, NY 10016 USA.
EM gordon.fishell@med.nyu.edu
RI Karayannis, Theofanis/O-5194-2014
FU NIH [R01 NS081297, R01 MH071679, R01 NS074972, P01 NS074972, R01
   NS036362, R01 DA033811, NS30989, NS50220]; Simons Foundation [94534];
   Attilio and Olympia Ricciardi Research Fund; Israel Science Foundation;
   Patterson Trust; Roche; New York State through its NYSTEM initiative
   [C024326]; Canadian Institutes of Health Research; NYU COE Addiction
   Seed Grant; Institut Pasteur; INSERM; AP-HP; University Paris Diderot;
   Bettencourt-Schueller foundation; Orange foundation; FondaMental
   foundation; Conny-Maeva foundation; Cognacq-Jay foundation
FX The authors are grateful to R. Froemke for critically reading the
   manuscript, to B. Benedetti, M. McKenzie Chang, L. Cobbs, B. A. Heller,
   T. Petros and N. Yumoto (all NYU) for help with experiments and analysis
   and to Charles Nicholson (NYU) for providing specialized software to
   analyse Vmax. Research in the Fishell laboratory is supported by the NIH
   (grants R01 NS081297, R01 MH071679, R01 NS074972, P01 NS074972 to B. R.
   and G. F.) and the Simons Foundation (94534). The Rice laboratory is
   supported by the NIH (grants R01 NS036362 and R01 DA033811) and the
   Attilio and Olympia Ricciardi Research Fund. The Rudy laboratory is
   supported by the NIH (NS30989). The Peles laboratory is supported by the
   NIH (grant NS50220) and the Israel Science Foundation. T. K. support was
   provided through postdoctoral fellowships from the Patterson Trust and
   Roche. E. A. support was provided by New York State through its NYSTEM
   initiative (C024326) and fellowship from Canadian Institutes of Health
   Research. J.C.P support was provided by NYU COE Addiction Seed Grant.
   This work was funded by the Institut Pasteur, INSERM, AP-HP, University
   Paris Diderot and the Bettencourt-Schueller, Orange, FondaMental,
   Conny-Maeva, Cognacq-Jay foundations.
CR Abecasis GR, 2004, AM J HUM GENET, V74, P403, DOI 10.1086/381713
   Ashrafi S, 2014, NEURON, V81, P120, DOI 10.1016/j.neuron.2013.10.060
   Atasoy D, 2007, P NATL ACAD SCI USA, V104, P2525, DOI 10.1073/pnas.0611003104
   Batista-Brito R, 2009, NEURON, V63, P466, DOI 10.1016/j.neuron.2009.08.005
   Belzil C, 2013, J BIOL CHEM, V288, P24452, DOI 10.1074/jbc.M113.483107
   Berghuis P, 2004, EUR J NEUROSCI, V20, P1290, DOI 10.1111/j.1460-9568.2004.03561.x
   Blatt GJ, 2011, ANAT REC, V294, P1646, DOI 10.1002/ar.21252
   Brandon NJ, 2003, MOL CELL NEUROSCI, V22, P87, DOI 10.1016/S1044-7431(02)00017-9
   Castellanos FX, 1996, BIOL PSYCHIAT, V39, P33, DOI 10.1016/0006-3223(95)00101-8
   Cathala L, 2005, NAT NEUROSCI, V8, P1310, DOI 10.1038/nn1534
   Champagne FA, 2004, J NEUROSCI, V24, P4113, DOI 10.1523/JNEUROSCI.5322-03.2004
   Chang MC, 2010, NAT NEUROSCI, V13, P1090, DOI 10.1038/nn.2621
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Close J, 2012, J NEUROSCI, V32, P17690, DOI 10.1523/JNEUROSCI.3583-12.2012
   CONDE F, 1994, J COMP NEUROL, V341, P95, DOI 10.1002/cne.903410109
   Crowley JJ, 2012, PHARMACOGENOMICS J, V12, P147, DOI 10.1038/tpj.2010.82
   Doischer D, 2008, J NEUROSCI, V28, P12956, DOI 10.1523/JNEUROSCI.2890-08.2008
   Elia J, 2012, NAT GENET, V44, P78, DOI 10.1038/ng.1013
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Fazzari P, 2010, NATURE, V464, P1376, DOI 10.1038/nature08928
   Feinberg K, 2010, NEURON, V65, P490, DOI 10.1016/j.neuron.2010.02.004
   Foster AC, 2004, J PHARMACOL EXP THER, V311, P547, DOI 10.1124/jpet.103.063487
   Geyer MA, 2001, PSYCHOPHARMACOLOGY, V156, P117, DOI 10.1007/s002130100811
   Glessner JT, 2010, P NATL ACAD SCI USA, V107, P10584, DOI 10.1073/pnas.1000274107
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Gonzalez MI, 2013, EPILEPSIA, V54, P616, DOI 10.1111/epi.12063
   Grados MA, 2009, CURR PSYCHIAT REP, V11, P162
   HAYCOCK JW, 1987, BRAIN RES BULL, V19, P619, DOI 10.1016/0361-9230(87)90046-3
   Hefft S, 2005, NAT NEUROSCI, V8, P1319, DOI 10.1038/nn1542
   Ho A, 2003, P NATL ACAD SCI USA, V100, P1409, DOI 10.1073/pnas.252774899
   Hoeffer CA, 2008, NEURON, V60, P832, DOI 10.1016/j.neuron.2008.09.037
   Hoon M, 2009, J NEUROSCI, V29, P8039, DOI 10.1523/JNEUROSCI.0534-09.2009
   Jordan BA, 2004, MOL CELL PROTEOMICS, V3, P857, DOI 10.1074/mcp.M400045-MCP200
   Karayiorgou M, 2004, AM J MED GENET B, V124B, P20, DOI 10.1002/ajmg.b.20090
   Klausberger T, 2002, J NEUROSCI, V22, P2513
   Krueger DD, 2012, CURR OPIN NEUROBIOL, V22, P412, DOI 10.1016/j.conb.2012.02.012
   Labasque M, 2010, FEBS LETT, V584, P1787, DOI 10.1016/j.febslet.2009.08.025
   Lewis DA, 2012, EUR J NEUROSCI, V35, P1871, DOI 10.1111/j.1460-9568.2012.08156.x
   Li MY, 2005, AM J HUM GENET, V76, P934, DOI 10.1086/430277
   Li MY, 2006, AM J HUM GENET, V78, P778, DOI 10.1086/503711
   Li XT, 2010, J NEUROSCI, V30, P1788, DOI 10.1523/JNEUROSCI.5604-09.2010
   Li Y, 2010, GENET EPIDEMIOL, V34, P816, DOI 10.1002/gepi.20533
   MacAskill AF, 2009, NEURON, V61, P541, DOI 10.1016/j.neuron.2009.01.030
   Miyoshi G, 2007, J NEUROSCI, V27, P7786, DOI 10.1523/JNEUROSCI.1807-07.2007
   Miyoshi G, 2012, NEURON, V74, P1045, DOI 10.1016/j.neuron.2012.04.025
   Miyoshi G, 2010, J NEUROSCI, V30, P1582, DOI 10.1523/JNEUROSCI.4515-09.2010
   Nicholson C., 2010, P 13 INT C IN VIV ME, P328
   Nikolaev A, 2009, NATURE, V457, P981, DOI 10.1038/nature07767
   Osten P, 1998, NEURON, V21, P99, DOI 10.1016/S0896-6273(00)80518-8
   Panzanelli P, 2011, J PHYSIOL-LONDON, V589, P4959, DOI 10.1113/jphysiol.2011.216028
   Patel Jyoti C, 2013, Methods Mol Biol, V964, P243, DOI 10.1007/978-1-62703-251-3_15
   Patel JC, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2144
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Petroski RE, 2006, J PHARMACOL EXP THER, V317, P369, DOI 10.1124/jpet.105.096701
   Phillips GR, 2001, NEURON, V32, P63, DOI 10.1016/S0896-6273(01)00450-0
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Restituito S, 2011, J NEUROSCI, V31, P12083, DOI 10.1523/JNEUROSCI.2513-11.2011
   Rice ME, 2011, NEUROSCIENCE, V198, P112, DOI 10.1016/j.neuroscience.2011.08.066
   Spiegel I, 2007, NAT NEUROSCI, V10, P861, DOI 10.1038/nn1915
   Spiegel I, 2002, MOL CELL NEUROSCI, V20, P283, DOI 10.1006/mcne.2002.1110
   Stark KL, 2009, INT J NEUROPSYCHOPH, V12, P983, DOI 10.1017/S1461145709000492
   Sylwestrak EL, 2012, SCIENCE, V338, P536, DOI 10.1126/science.1222482
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
   Xu B, 2009, P NATL ACAD SCI USA, V106, P16746, DOI 10.1073/pnas.0908584106
NR 66
TC 5
Z9 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD JUL 10
PY 2014
VL 511
IS 7508
BP 236
EP +
DI 10.1038/nature13248
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK8AP
UT WOS:000338649800047
PM 24870235
ER

PT J
AU Gallagher, S
AF Gallagher, Shaun
TI In your face: transcendence in embodied interaction
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE interaction; face; ethics; transcendence; Levinas
ID MOBIUS SEQUENCE; IMITATION; RECOGNITION; PERCEPTION; INFANTS; NEWBORNS;
   MEMORY
AB In cognitive psychology, studies concerning the face tend to focus on questions about face recognition, theory of mind (ToM) and empathy. Questions about the face, however, also fit into a very different set of issues that are central to ethics. Based especially on the work of Levinas, philosophers have come to see that reference to the face of another person can anchor conceptions of moral responsibility and ethical demand. Levinas points to a certain irreducibility and transcendence implicit in the face of the other. In this paper I argue that the notion of transcendence involved in this kind of analysis can be given a naturalistic interpretation by drawing on recent interactive approaches to social cognition found in developmental psychology, phenomenology, and the study of autism.
C1 [Gallagher, Shaun] Memphis State Univ, Dept Philosophy, Memphis, TN 38152 USA.
   [Gallagher, Shaun] Univ Hertfordshire, Sch Humanities, Dept Philosophy, Hatfield AL10 9AB, Herts, England.
   [Gallagher, Shaun] Univ Wollongong, Fac Law Humanities & Arts, Dept Philosophy, Wollongong, NSW, Australia.
RP Gallagher, S (reprint author), Memphis State Univ, Dept Philosophy, 331 Clement Hall, Memphis, TN 38152 USA.
EM s.gallagher@memphis.edu
FU Marie-Curie Initial Training Network, TESIS: toward an Embodied Science
   of Inter Subjectivity [PEOPLE-2010-ITN, 264828]; Humboldt Foundation,
   Anneliese Maier Research Award
FX This work is supported the Marie-Curie Initial Training Network," TESIS:
   toward an Embodied Science of Inter Subjectivity" (FP7-PEOPLE-2010-ITN,
   264828), and the Humboldt Foundation, Anneliese Maier Research Award. An
   earlier version of this paper was presented at the Workshop on Other
   Minds. St. Hilda's College, Oxford University (12 March 2013).
CR Addington J, 1998, SCHIZOPHR RES, V32, P171, DOI 10.1016/S0920-9964(98)00042-5
   Barrett LF, 2009, PHILOS T R SOC B, V364, P1325, DOI 10.1098/rstb.2008.0312
   Bergo B, 2011, ANGELAKI, V16, P17, DOI 10.1080/0969725X.2011.564362
   Briegel W, 2006, CLIN GENET, V70, P91, DOI 10.1111/j.1399-0004.2006.00649.x
   Briegel W, 2007, CLIN GENET, V71, P376, DOI 10.1111/j.1399-004.2007.00787.x
   Bushnell IWR, 2001, INFANT CHILD DEV, V10, P67, DOI 10.1002/icd.248
   Cole J., 1999, MODELS SELF, P301
   Cole J., 1999, FACE
   Cole Jonathan, 2009, INVISIBLE SMILE LIVI
   Debruille JB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047922
   Decety J, 2003, NEUROPSYCHOLOGIA, V41, P127, DOI 10.1016/S0028-3932(02)00143-4
   De Jaegher H, 2010, TRENDS COGN SCI, V14, P441, DOI 10.1016/j.tics.2010.06.009
   Di Paolo E, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00163
   Di Paolo EA, 2013, TRENDS COGN SCI, V17, P303, DOI 10.1016/j.tics.2013.05.003
   Di Paolo EA, 2008, NEW IDEAS PSYCHOL, V26, P278, DOI 10.1016/j.newideapsych.2007.07.006
   Fiebich A, 2012, THESIS RUHR U BOCHUM
   FIELD TM, 1982, SCIENCE, V218, P179, DOI 10.1126/science.7123230
   Gallagher S, 2008, SHARED MIND PERSPECT, P17
   Gallagher S, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00585
   Gallagher S., 2012, REV PHILOS PSYCHOL, V3, P187, DOI [10.1007/s13164-011-0080-1, DOI 10.1007/S13164-011-0080-1]
   Gallagher S, 1996, PHILOS PSYCHOL, V9, P211, DOI 10.1080/09515089608573181
   Gallagher S, 2008, CONSCIOUS COGN, V17, P535, DOI 10.1016/j.concog.2008.03.003
   Gallagher S., 2005, BODY SHAPES MIND
   Gallagher S, 2001, J CONSCIOUSNESS STUD, V8, P83
   Goldman A., 2006, SIMULATING MINDS PHI
   Gopnik Alison, 1997, WORDS THOUGHTS THEOR
   Grossman Dave, 1996, KILLING PSYCHOL COST
   GUENTHER LISA, 2013, SOLITARY CONFINEMENT
   Hendricks-Jansen B, 1996, CATCHING OURSELVES A, P309
   Hurley S. L., 2004, PERSPECTIVES IMITATI, V2
   Izard C. E., 2000, EMOTION DEV SELF ORG, P15, DOI 10.1017/CBO9780511527883.003
   Izard C. E., 1972, PATTERNS EMOTIONS NE
   JOHNSON MH, 1991, COGNITION, V40, P1, DOI 10.1016/0010-0277(91)90045-6
   Johnson S, 2000, AM ECON REV, V90, P22, DOI 10.1257/aer.90.2.22
   Karmiloff-Smith A., 1992, MODULARITY DEV PERSP
   Klinnert M. D., 1983, EMOTION THEORY RES E, V2, P57
   Krueger J, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00081
   Krueger J, 2012, PHENOMENOL COGN SCI, V11, P149, DOI 10.1007/s11097-011-9226-y
   Leslie A., 1987, OXFORD COMPANION MIN, P164
   Levinas Emmanuel, 1991, ENTRE NOUS ESSAIS PE
   Levinas Emmanuel, 1969, TOTALITY INFINITY
   Meltzoff AN, 1997, EARLY DEV PARENTING, V6, P179, DOI 10.1002/(SICI)1099-0917(199709/12)6:3/4<179::AID-EDP157>3.0.CO;2-R
   MELTZOFF AN, 1994, INFANT BEHAV DEV, V17, P83, DOI 10.1016/0163-6383(94)90024-8
   MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
   Merleau-Ponty M, 2002, PHENOMENOLOGY PERCEP
   Merleau-Ponty M, 1964, SENSE NONSENSE
   Mondloch CJ, 1999, PSYCHOL SCI, V10, P419, DOI 10.1111/1467-9280.00179
   Mumme DL, 1996, CHILD DEV, V67, P3219, DOI 10.1111/j.1467-8624.1996.tb01910.x
   Newen A., MIND LANG IN PRESS
   Protevi J, 2008, PHENOMENOL COGN SCI, V7, P405, DOI 10.1007/s11097-008-9097-z
   Purcell M, 2006, LEVINAS AND THEOLOGY, P1, DOI 10.2277/ 0521012805
   Reddy V., 2008, INFANTS KNOW MINDS
   Sartre J-P., 1956, BEING NOTHINGNESS
   Sass L. A., 2013, PHENOMENOLOGY COGN S, DOI [10.1007/s11097-013-9340-0, DOI 10.1007/S11097-013-9340-0]
   Shuler MG, 2006, SCIENCE, V311, P1606, DOI 10.1126/science.1123513
   Stawarska Beata, 2009, YOU I DIALOGICAL PHE
   Stern D., 1985, INTERPERSONAL WORLD
   Thompson E., 2007, MIND LIFE BIOL PHENO
   Trevarthen C., 1979, SPEECH BEGINNING INT, P321
   Trevarthen C., 1978, ACTION GESTURE SYMBO, P183
   Trevarthen C, 2001, J CHILD PSYCHOL PSYC, V42, P3, DOI 10.1017/S0021963001006552
   TRONICK E, 1978, J AM ACAD CHILD PSY, V17, P1, DOI 10.1016/S0002-7138(09)62273-1
   Veling T. A., 1999, PACIFICA, V12, P275
   WALTON GE, 1992, INFANT BEHAV DEV, V15, P265, DOI 10.1016/0163-6383(92)80027-R
   Wittgenstein Ludwig, 1967, ZETTEL
   Wittgenstein Ludwig, 1980, REMARKS PHILOS PSYCH
NR 66
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JUL 9
PY 2014
VL 8
AR 495
DI 10.3389/fnhum.2014.00495
PG 6
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AM7OO
UT WOS:000340057400001
PM 25071523
ER

PT J
AU Sansone, SM
   Schneider, A
   Bickel, E
   Berry-Kravis, E
   Prescott, C
   Hessl, D
AF Sansone, Stephanie M.
   Schneider, Andrea
   Bickel, Erika
   Berry-Kravis, Elizabeth
   Prescott, Christina
   Hessl, David
TI Improving IQ measurement in intellectual disabilities using true
   deviation from population norms
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE IQ; Intellectual disability; Autism spectrum disorder; Fragile X
   syndrome; Cognitive assessment
ID FRAGILE-X-SYNDROME; PERVASIVE DEVELOPMENTAL DISORDERS;
   COGNITIVE-ABILITIES; MENTAL-RETARDATION; AUTISM; INTELLIGENCE; CHILDREN;
   INDIVIDUALS; CARRIERS
AB Background: Intellectual disability (ID) is characterized by global cognitive deficits, yet the very IQ tests used to assess ID have limited range and precision in this population, especially for more impaired individuals.
   Methods: We describe the development and validation of a method of raw z-score transformation (based on general population norms) that ameliorates floor effects and improves the precision of IQ measurement in ID using the Stanford Binet 5 (SB5) in fragile X syndrome (FXS; n = 106), the leading inherited cause of ID, and in individuals with idiopathic autism spectrum disorder (ASD; n = 205). We compared the distributional characteristics and Q-Q plots from the standardized scores with the deviation z-scores. Additionally, we examined the relationship between both scoring methods and multiple criterion measures.
   Results: We found evidence that substantial and meaningful variation in cognitive ability on standardized IQ tests among individuals with ID is lost when converting raw scores to standardized scaled, index and IQ scores. Use of the deviation z-score method rectifies this problem, and accounts for significant additional variance in criterion validation measures, above and beyond the usual IQ scores. Additionally, individual and group-level cognitive strengths and weaknesses are recovered using deviation scores.
   Conclusion: Traditional methods for generating IQ scores in lower functioning individuals with ID are inaccurate and inadequate, leading to erroneously flat profiles. However assessment of cognitive abilities is substantially improved by measuring true deviation in performance from standardization sample norms. This work has important implications for standardized test development, clinical assessment, and research for which IQ is an important measure of interest in individuals with neurodevelopmental disorders and other forms of cognitive impairment.
C1 [Sansone, Stephanie M.; Schneider, Andrea; Bickel, Erika; Hessl, David] Univ Calif Davis, Med Ctr, Med Invest Neurodev Disorders MIND Inst, Sacramento, CA 95817 USA.
   [Berry-Kravis, Elizabeth; Prescott, Christina] Rush Univ, Med Ctr, Dept Pediat, Chicago, IL 60612 USA.
   [Berry-Kravis, Elizabeth; Prescott, Christina] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
   [Berry-Kravis, Elizabeth; Prescott, Christina] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA.
   [Hessl, David] Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
   [Schneider, Andrea] Univ Calif Davis, Sch Med, Dept Pediat, Sacramento, CA 95817 USA.
RP Hessl, D (reprint author), Univ Calif Davis, Med Ctr, Med Invest Neurodev Disorders MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM david.hessl@ucdmc.ucdavis.edu
FU National Institute of Mental Health [1U24MH081810]; UC Davis School of
   Medicine Office; National Fragile X Foundation
FX We gratefully acknowledge the resources provided by the Autism Genetic
   Resource Exchange (AGRE) Consortium and the participating AGRE families.
   The Autism Genetic Resource Exchange is a program of Autism Speaks and
   is supported, in part, by grant 1U24MH081810 from the National Institute
   of Mental Health to Clara M Lajonchere (PI). We thank Gale Roid (lead
   author of the SB5), Elizabeth Allen (Director of Research and
   Development at PRO-ED, Inc.), Ryan Butler and Tiffany Torigoe (AGRE),
   and Shrikant Pandya (data entry at Rush). The UC Davis School of
   Medicine Office of the Dean and a philanthropic donation from the
   Fragile X LINKS Group of Greater Chicago in conjunction with the
   National Fragile X Foundation supported this work.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Backes M, 2000, AM J MED GENET, V95, P150
   Ben IE, 2008, RES DEV DISABIL, V29, P447
   Carroll JB, 1997, INTELLIGENCE, V24, P25, DOI 10.1016/S0160-2896(97)90012-X
   Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
   Coolican J, 2008, J AUTISM DEV DISORD, V38, P190, DOI 10.1007/s10803-007-0368-2
   Couzens D, 2004, INT J DISABIL DEV ED, V51, P39, DOI DOI 10.1080/1034912042000182193
   DEVYS D, 1993, NAT GENET, V4, P335, DOI 10.1038/ng0893-335
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   Facon B, 2008, RES DEV DISABIL, V29, P29, DOI 10.1016/j.ridd.2006.10.003
   Fisch G, 2006, AM J MED GENET A, V677, P673
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Hagerman PJ, 2008, J MED GENET, V45, P498, DOI 10.1136/jmg.2008.059055
   HAY DA, 1994, AM J MED GENET, V51, P358, DOI 10.1002/ajmg.1320510412
   Haynes SN, 2003, PSYCHOL ASSESSMENT, V15, P456, DOI 10.1037/1040-3590.15.4.456
   Hessl D, 2009, J NEURODEV DISORD, V1, P33, DOI 10.1007/s11689-008-9001-8
   Irwin SA, 2000, CEREB CORTEX, V10, P1038, DOI 10.1093/cercor/10.10.1038
   Lewis P, 2006, J INTELL DISABIL RES, V50, P532, DOI 10.1111/j.1365-2788.2006.00803.x
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P60, DOI 10.1016/j.rasd.2007.03.003
   McGrew KS, 1997, SCHOOL PSYCHOL REV, V26, P189
   R Core Team, 2013, R LANG ENV STAT COMP
   Raven J., 2003, MANUAL RAVENS PROGR
   Roid G. H., 2003, STANFORD BINET INTEL
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   TAYLOR AK, 1994, JAMA-J AM MED ASSOC, V271, P507, DOI 10.1001/jama.271.7.507
   Van der Molen MJW, 2010, RES DEV DISABIL, V31, P426, DOI 10.1016/j.ridd.2009.10.013
   Whitaker S, 2012, INT J DEV DISABIL, V58, P111, DOI 10.1179/2047387711Y.0000000012
   Whitaker S, 2008, J APPL RES INTELLECT, V21, P136, DOI 10.1111/j.1468-3148.2007.00378.x
NR 30
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUL 8
PY 2014
VL 6
AR 16
DI 10.1186/1866-1955-6-16
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CC5ZL
UT WOS:000350444000001
ER

PT J
AU Schreiber, JM
   Lanham, DC
   Trescher, WH
   Sparks, SE
   Wassif, CA
   Caffo, BS
   Porter, FD
   Tierney, E
   Gropman, AL
   Ewen, JB
AF Schreiber, John M.
   Lanham, Diane C.
   Trescher, William H.
   Sparks, Susan E.
   Wassif, Christopher A.
   Caffo, Brian S.
   Porter, Forbes D.
   Tierney, Elaine
   Gropman, Andrea L.
   Ewen, Joshua B.
TI Variations in EEG discharges predict ADHD severity within individual
   Smith-Lemli-Opitz patients
SO NEUROLOGY
LA English
DT Article
ID INTERICTAL EEG; EPILEPSY; CHILDREN; ABNORMALITIES; DIAGNOSIS
AB Objective: We sought to examine the prevalence of EEG abnormalities in Smith-Lemli-Opitz syndrome (SLOS) as well as the relationship between interictal epileptiform discharges (IEDs) and within-subject variations in attentional symptom severity.
   Methods: In the context of a clinical trial for SLOS, we performed cross-sectional and repeated-measure observational studies of the relationship between EEG findings and cognitive/behavioral factors on 23 children (aged 4-17 years). EEGs were reviewed for clinical abnormalities, including IEDs, by readers blinded to participants' behavioral symptoms. Between-group differences in baseline characteristics of participants with and without IEDs were analyzed. Within-subject analyses examined the association between the presence of IEDs and changes in attention-deficit/hyperactivity disorder (ADHD) symptoms.
   Results: Of 85 EEGs, 43 (51%) were abnormal, predominantly because of IEDs. Only one subject had documented clinical seizures. IEDs clustered in 13 subjects (57%), whereas 9 subjects (39%) had EEGs consistently free of IEDs. While there were no significant group differences in sex, age, intellectual disability, language level, or baseline ADHD symptoms, autistic symptoms tended to be more prevalent in the "IED" group (according to Autism Diagnostic Observation Schedule-2 criteria). Within individuals, the presence of IEDs on a particular EEG predicted, on average, a 27% increase in ADHD symptom severity.
   Conclusions: Epileptiform discharges are common in SLOS, despite a relatively low prevalence of epilepsy. Fluctuations in the presence of epileptiform discharges within individual children with a developmental disability syndrome may be associated with fluctuations in ADHD symptomatology, even in the absence of clinical seizures.
C1 [Schreiber, John M.] NINDS, EEG Sect, NIH, Bethesda, MD 20892 USA.
   [Sparks, Susan E.; Gropman, Andrea L.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
   [Wassif, Christopher A.] NICHD, Program Dev Endocrinol & Genet, NIH, Bethesda, MD USA.
   [Lanham, Diane C.; Tierney, Elaine] Kennedy Krieger Inst, Dept Child & Adolescent Psychiat, Baltimore, MD USA.
   [Trescher, William H.; Ewen, Joshua B.] Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA.
   [Trescher, William H.; Ewen, Joshua B.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
   [Tierney, Elaine] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Trescher, William H.; Porter, Forbes D.] Penn State Hershey Childrens Hosp, Dept Pediat Neurol, Hershey, PA USA.
   [Caffo, Brian S.] Johns Hopkins Univ, Sch Publ Hlth, Dept Biostat, Baltimore, MD USA.
   [Gropman, Andrea L.] Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA.
   [Gropman, Andrea L.] George Washington Univ Hlth Sci, Washington, DC USA.
RP Ewen, JB (reprint author), Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA.
EM Ewen@kennedykrieger.org
FU Autism Speaks; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development (NICHD); Kennedy Krieger/Johns Hopkins NICHD
   Intellectual and Developmental Disabilities Research Center core grant
   [P30 HD024061]; National Center for Advancing Translational Sciences
   (NCATS), a component of the NIH [UL1 TR 000424-06]; NIH Roadmap for
   Medical Research; Bench to Bedside award from the Office of Rare
   Diseases; NIH Clinical Center; NICHD; National Institute of Neurological
   Disorders and Stroke/NIH [K23 NS073626]
FX This research was supported by Autism Speaks, the intramural research
   program of the Eunice Kennedy Shriver National Institute of Child Health
   and Human Development (NICHD), and by the Kennedy Krieger/Johns Hopkins
   NICHD Intellectual and Developmental Disabilities Research Center core
   grant P30 HD024061. This publication was made possible by the Johns
   Hopkins Institute for Clinical and Translational Research (ICTR), which
   is funded in part by grant UL1 TR 000424-06 from the National Center for
   Advancing Translational Sciences (NCATS), a component of the NIH, and
   NIH Roadmap for Medical Research. Its contents are solely the
   responsibility of the authors and do not necessarily represent the
   official view of the Johns Hopkins ICTR, NCATS, or NIH. This project was
   also supported by a Bench to Bedside award to F. D. P. from the Office
   of Rare Diseases, NIH Clinical Center, and NICHD; and by National
   Institute of Neurological Disorders and Stroke/NIH grant K23 NS073626
   awarded to J.B.E.
CR AARTS JHP, 1984, BRAIN, V107, P293, DOI 10.1093/brain/107.1.293
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bates D, IME4 LINEAR MIXED EF
   BERNARDINA B D, 1976, Epilepsia, V17, P161, DOI 10.1111/j.1528-1157.1976.tb03393.x
   Conners C. K., 1997, CONNERS RATING SCALE
   Cooper R A, 1998, Eur J Paediatr Neurol, V2, P127, DOI 10.1016/S1090-3798(98)80028-7
   EEGOLOFS.O, 1971, NEUROPADIATRIE, V2, P375, DOI 10.1055/s-0028-1091791
   Ewen JB, 2011, EPILEPSY RES, V97, P214, DOI 10.1016/j.eplepsyres.2011.07.015
   Faraway JJ, 2006, EXTENDING LINEAR MOD
   Gadow K. D., 2000, EARLY CHILDHOOD INVE
   Gadow K. D., 2002, CHILD SYMPTOM INVENT
   Gadow K. D., 1998, ADOLESCENT SYMPTOM I
   Goldstein H., 2002, Understanding Statistics, V1, DOI 10.1207/S15328031US0104_02
   GOODIN DS, 1984, LANCET, V1, P837
   Kellaway P, 1981, CURRENT CLIN NEUROPH, P151
   Kelley RI, 2000, J MED GENET, V37, P321, DOI 10.1136/jmg.37.5.321
   Kluger G, 1996, PEDIATR NEUROL, V15, P358, DOI 10.1016/S0887-8994(96)00251-2
   Kossoff EH, 2007, EPILEPSY BEHAV, V11, P514, DOI 10.1016/j.yebeh.2007.07.011
   Lesnoff M, AOD ANAL OVERDISPERS
   Lord C., 2012, AUTISM DIAGNOSTIC 1
   MARSAN CA, 1970, EPILEPSIA, V11, P361, DOI 10.1111/j.1528-1157.1970.tb03903.x
   Mullen E, 1995, MULLEN SCALES EARLY
   R Core Team, R LANG ENV STAT COMP
   Roid G. H., 2003, STANFORD BINET INTEL
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Ryan AK, 1998, J MED GENET, V35, P558, DOI 10.1136/jmg.35.7.558
   SALINSKY M, 1987, EPILEPSIA, V28, P331, DOI 10.1111/j.1528-1157.1987.tb03652.x
   Silvestri R, 2007, EPILEPSY RES, V75, P130, DOI 10.1016/j.eplepsyres.2007.05.007
   Sparrow SS, 2000, VINELAND ADAPTIVE BE
   Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
NR 30
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
EI 1526-632X
J9 NEUROLOGY
JI Neurology
PD JUL 8
PY 2014
VL 83
IS 2
BP 151
EP 159
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA AM8EI
UT WOS:000340103400041
PM 24920862
ER

PT J
AU Jeste, SS
   Wu, JY
   Senturk, D
   Varcin, K
   Ko, J
   McCarthy, B
   Shimizu, C
   Dies, K
   Vogel-Farley, V
   Sahin, M
   Nelson, CA
AF Jeste, Shafali Spurling
   Wu, Joyce Y.
   Senturk, Damla
   Varcin, Kandice
   Ko, Jordan
   McCarthy, Brigid
   Shimizu, Christina
   Dies, Kira
   Vogel-Farley, Vanessa
   Sahin, Mustafa
   Nelson, Charles A., III
TI Early developmental trajectories associated with ASD in infants with
   tuberous sclerosis complex
SO NEUROLOGY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE; SEIZURE
   ONSET; BABY SIBLINGS; CHILDREN; EPILEPSY; RISK
AB Objective: We performed a longitudinal cohort study of infants with tuberous sclerosis complex (TSC), with the overarching goal of defining early clinical, behavioral, and biological markers of autism spectrum disorder (ASD) in this high-risk population.
   Methods: Infants with TSC and typically developing controls were recruited as early as 3 months of age and followed longitudinally until 36 months of age. Data gathered at each time point included detailed seizure history, developmental testing using the Mullen Scales of Early Learning, and social-communication assessments using the Autism Observation Scale for Infants. At 18 to 36 months, a diagnostic evaluation for ASD was performed using the Autism Diagnostic Observation Schedule.
   Results: Infants with TSC demonstrated delays confined to nonverbal abilities, particularly in the visual domain, which then generalized to more global delays by age 9 months. Twenty-two of 40 infants with TSC were diagnosed with ASD. Both 12-month cognitive ability and developmental trajectories over the second and third years of life differentiated the groups. By 12 months of age, the ASD group demonstrated significantly greater cognitive delays and a significant decline in nonverbal IQ from 12 to 36 months.
   Conclusions: This prospective study characterizes early developmental markers of ASD in infants with TSC. The early delay in visual reception and fine motor ability in the TSC group as a whole, coupled with the decline in nonverbal ability in infants diagnosed with ASD, suggests a domain-specific pathway to ASD that can inform more targeted interventions for these high-risk infants.
C1 [Jeste, Shafali Spurling; Ko, Jordan; McCarthy, Brigid; Shimizu, Christina] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat, Los Angeles, CA 90024 USA.
   [Jeste, Shafali Spurling] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Neurol, Los Angeles, CA 90024 USA.
   [Wu, Joyce Y.] Univ Calif Los Angeles, Mattel Childrens Hosp, Div Pediat Neurol, Los Angeles, CA USA.
   [Senturk, Damla] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA.
   [Varcin, Kandice; Vogel-Farley, Vanessa; Nelson, Charles A., III] Harvard Univ, Sch Med, Boston Childrens Hosp, Labs Cognit Neurosci, Boston, MA USA.
   [Dies, Kira] Harvard Univ, Sch Med, Dept Neurol, Div Dev Med,Boston Childrens Hosp, Boston, MA 02115 USA.
   [Sahin, Mustafa] Harvard Univ, Sch Med, Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA USA.
   Harvard Univ, Sch Med, Dept Neurol, Boston Childrens Hosp, Boston, MA 02115 USA.
RP Jeste, SS (reprint author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat, Los Angeles, CA 90024 USA.
EM Sjeste@mednet.ucla.edu
FU Department of Defense (DOD CDMRP TSCRP); UCLA CTSI [UL1RR033176]
FX Supported by the Department of Defense (DOD CDMRP TSCRP: 2011-2014) and
   UCLA CTSI (UL1RR033176).
CR Bolton PF, 2002, BRAIN, V125, P1247, DOI 10.1093/brain/awf124
   Bombardieri R, 2010, EUR J PAEDIATR NEURO, V14, P146, DOI 10.1016/j.ejpn.2009.03.003
   Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500
   Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
   Crino PB, 2006, NEW ENGL J MED, V355, P1345, DOI 10.1056/NEJMra055323
   Curatolo P, 2010, J CHILD NEUROL, V25, P873, DOI 10.1177/0883073810361789
   Cusmai R, 2011, EPILEPSY BEHAV, V22, P735, DOI 10.1016/j.yebeh.2011.08.037
   Datta AN, 2008, J CHILD NEUROL, V23, P268, DOI 10.1177/0883073807309250
   de Vries PJ, 2007, EUR CHILD ADOLES PSY, V16, P16, DOI 10.1007/s00787-006-0570-3
   Deonna T, 2007, DEV MED CHILD NEUROL, V49, P320
   de Vries PJ, 2007, NEW ENGL J MED, V356, P92
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Humphrey A, 2006, DEV MED CHILD NEUROL, V48, P609, DOI 10.1017/S0012162206001277
   JAMBAQUE I, 1991, DEV MED CHILD NEUROL, V33, P698
   Jeste SS, 2012, J CHILD NEUROL, V28, P1569
   Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
   Jones W, 2013, NATURE, V504, P427, DOI 10.1038/nature12715
   Korman B, 2013, NEUROLOGY, V81, P745, DOI 10.1212/WNL.0b013e3182a1aa2a
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Landa RJ, 2012, J CHILD PSYCHOL PSYC, V53, P986, DOI 10.1111/j.1469-7610.2012.02558.x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mettin RR, 2014, BRAIN DEV-JPN, V36, P306, DOI 10.1016/j.braindev.2013.05.006
   Mullen E, 1995, MULLEN SCALES EARLY
   Nie D, 2010, NAT NEUROSCI, V13, P163, DOI 10.1038/nn.2477
   O'Callaghan FJK, 2004, ARCH DIS CHILD, V89, P530, DOI 10.1136/adc.2003.026815
   Orlova KA, 2010, ANN NY ACAD SCI, V1184, P87, DOI 10.1111/j.1749-6632.2009.05117.x
   OSBORNE JP, 1991, ANN NY ACAD SCI, V615, P125, DOI 10.1111/j.1749-6632.1991.tb37754.x
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Smalley SL, 1998, J AUTISM DEV DISORD, V28, P407, DOI 10.1023/A:1026052421693
   Winarni T.I., 2012, CASE REP GENET, V2012
   Wiznitzer M, 2004, J CHILD NEUROL, V19, P675
   Wright CA, 2013, J SPEECH LANG HEAR R, V56, P994, DOI 10.1044/1092-4388(2012/12-0060)
   Zwaigenbaum L, 2010, CURR OPIN NEUROL, V23, P97, DOI 10.1097/WCO.0b013e3283372430
NR 34
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
EI 1526-632X
J9 NEUROLOGY
JI Neurology
PD JUL 8
PY 2014
VL 83
IS 2
BP 160
EP 168
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA AM8EI
UT WOS:000340103400042
ER

PT J
AU Castro, J
   Garcia, RI
   Kwok, S
   Banerjee, A
   Petravicz, J
   Woodson, J
   Mellios, N
   Tropea, D
   Sur, M
AF Castro, Jorge
   Garcia, Rodrigo I.
   Kwok, Showming
   Banerjee, Abhishek
   Petravicz, Jeremy
   Woodson, Jonathan
   Mellios, Nikolaos
   Tropea, Daniela
   Sur, Mriganka
TI Functional recovery with recombinant human IGF1 treatment in a mouse
   model of Rett Syndrome
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE molecular therapeutic; respiration; synaptic function; male mice; female
   mice
ID GROWTH-FACTOR-I; AUTISM SPECTRUM DISORDERS; MECP2 MUTANT MICE;
   RESPIRATORY-FUNCTION; SYNDROME PHENOTYPES; BRAIN; NEURONS; PLASTICITY;
   DEFICITS; INACTIVATION
AB Rett Syndrome is a neurodevelopmental disorder that arises from mutations in the X-linked gene methyl-CpG binding protein 2 (MeCP2). MeCP2 has a large number of targets and a wide range of functions, suggesting the hypothesis that functional signaling mechanisms upstream of synaptic and circuit maturation may contribute to our understanding of the disorder and provide insight into potential treatment. Here, we show that insulin-like growth factor-1 (IGF1) levels are reduced in young male Mecp2-null (Mecp2(-/y)) mice, and systemic treatment with recombinant human IGF1 (rhIGF1) improves lifespan, locomotor activity, heart rate, respiration patterns, and social and anxiety behavior. Furthermore, Mecp2-null mice treated with rhIGF1 show increased synaptic and activated signaling pathway proteins, enhanced cortical excitatory synaptic transmission, and restored dendritic spine densities. IGF1 levels are also reduced in older, fully symptomatic heterozygous (Mecp2(-/+)) female mice, and short-term treatment with rhIGF1 in these animals improves respiratory patterns, reduces anxiety levels, and increases exploratory behavior. In addition, rhIGF1 treatment normalizes abnormally prolonged plasticity in visual cortex circuits of adult Mecp2(-/+) female mice. Our results provide characterization of the phenotypic development of Rett Syndrome in a mouse model at the molecular, circuit, and organismal levels and demonstrate a mechanism-based therapeutic role for rhIGF1 in treating Rett Syndrome.
C1 [Castro, Jorge; Garcia, Rodrigo I.; Kwok, Showming; Banerjee, Abhishek; Petravicz, Jeremy; Woodson, Jonathan; Mellios, Nikolaos; Sur, Mriganka] MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Cambridge, MA 02139 USA.
   [Tropea, Daniela] St James Hosp, Trinity Ctr Hlth Sci, Neuropsychiat Genet Dept, Dublin D8, Ireland.
RP Sur, M (reprint author), MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, E25-618, Cambridge, MA 02139 USA.
EM msur@mit.edu
FU National Science Foundation [2388357]; Simons Center for the Social
   Brain; National Institutes of Health; Simons Foundation
FX We thank Alexandra Clemente and Jitendra Sharma, along with members of
   the M. S. laboratory, for technical assistance. This work was supported
   by National Science Foundation Graduate Research Fellowship 2388357 (to
   R. I. G.), a postdoctoral fellowship from the Simons Center for the
   Social Brain (to S. K. and A. B.), and grants from the National
   Institutes of Health and the Simons Foundation (to M.S.).
CR Amir RE, 2000, ANN NEUROL, V47, P670, DOI 10.1002/1531-8249(200005)47:5<670::AID-ANA20>3.0.CO;2-F
   Banerjee Abhishek, 2012, Front Psychiatry, V3, P34, DOI 10.3389/fpsyt.2012.00034
   Blackman MP, 2012, J NEUROSCI, V32, P13529, DOI 10.1523/JNEUROSCI.3077-12.2012
   Bondy CA, 2004, EUR J PHARMACOL, V490, P25, DOI 10.1016/j.ejphar.2004.02.042
   Bozdagi O, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-9
   Castro J, 2013, CURR OPIN NEUROL, V26, P154, DOI 10.1097/WCO.0b013e32835f19a7
   Chahrour M, 2008, SCIENCE, V320, P1224, DOI 10.1126/science.1153252
   Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
   Chang QA, 2006, NEURON, V49, P341, DOI 10.1016/j.neuron.2005.12.027
   Chao HT, 2007, NEURON, V56, P58, DOI 10.1016/j.neuron.2007.08.018
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Cheval H, 2012, HUM MOL GENET, V21, P3806, DOI 10.1093/hmg/dds208
   Ciucci F, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000475
   Cuesto G, 2011, J NEUROSCI, V31, P2721, DOI 10.1523/JNEUROSCI.4477-10.2011
   Derecki NC, 2013, TRENDS IMMUNOL, V34, P144, DOI 10.1016/j.it.2012.10.002
   Ehrlich I, 2004, J NEUROSCI, V24, P916, DOI 10.1523/JNEUROSCI.4733-03.2004
   Fernandez AM, 2012, NAT REV NEUROSCI, V13, P225, DOI 10.1038/nrn3209
   Feyder M, 2010, AM J PSYCHIAT, V167, P1508, DOI 10.1176/appi.ajp.2010.10040484
   Giacometti E, 2007, P NATL ACAD SCI USA, V104, P1931, DOI 10.1073/pnas.0610593104
   Gordon JA, 1996, J NEUROSCI, V16, P3274
   Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
   Guy J, 2011, ANNU REV CELL DEV BI, V27, P631, DOI 10.1146/annurev-cellbio-092910-154121
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Ishii T, 2001, BRAIN DEV-JPN, V23, pS161, DOI 10.1016/S0387-7604(01)00344-8
   Katz DM, 2012, DIS MODEL MECH, V5, P733, DOI 10.1242/dmm.011007
   Khwaja OS, 2014, P NATL ACAD SCI USA, V111, P4596, DOI 10.1073/pnas.1311141111
   Landi S, 2011, SCI REP-UK, V1, DOI 10.1038/srep00045
   Leiter EH, 2002, DIABETOLOGIA, V45, P296, DOI 10.1007/s00125-001-0743-z
   Li Y, 2013, CELL STEM CELL, V13, P446, DOI 10.1016/j.stem.2013.09.001
   Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
   Mellios N, 2014, P NATL ACAD SCI USA, V111, P9947, DOI 10.1073/pnas.1309426111
   Nguyen Minh Vu Chuong, 2012, J Neurosci, V32, P10021, DOI 10.1523/JNEUROSCI.1316-12.2012
   Nishijima T, 2010, NEURON, V67, P834, DOI 10.1016/j.neuron.2010.08.007
   Noutel J, 2011, NEURON, V70, P35, DOI 10.1016/j.neuron.2011.03.001
   Ogier M, 2007, J NEUROSCI, V27, P10912, DOI 10.1523/JNEUROSCI.1869-07.2007
   Pini G, 2012, AUTISM RES TREAT, V2012, DOI DOI 10.1155/2012/679801
   Pitcher MR, 2013, HUM MOL GENET, V22, P2626, DOI 10.1093/hmg/ddt111
   Ricciardi S, 2011, HUM MOL GENET, V20, P1182, DOI 10.1093/hmg/ddq563
   Saenger S, 2011, GROWTH HORM IGF RES, V21, P292, DOI 10.1016/j.ghir.2011.07.006
   Samaco RC, 2013, HUM MOL GENET, V22, P96, DOI 10.1093/hmg/dds406
   Schmid DA, 2012, J NEUROSCI, V32, P1803, DOI 10.1523/JNEUROSCI.0865-11.2012
   Shcheglovitov A, 2013, NATURE, V503, P267, DOI 10.1038/nature12618
   Sigmund CD, 2000, ARTERIOSCL THROM VAS, V20, P1425
   Stearns NA, 2007, NEUROSCIENCE, V146, P907, DOI 10.1016/j.neuroscience.2007.02.009
   Tropea D, 2009, P NATL ACAD SCI USA, V106, P2029, DOI 10.1073/pnas.0812394106
   Viemari JC, 2005, J NEUROSCI, V25, P11521, DOI 10.1523/JNEUROSCI.4373-05.2005
   Ward CS, 2011, J NEUROSCI, V31, P10359, DOI 10.1523/JNEUROSCI.0057-11.2011
   Weese-Mayer DE, 2006, PEDIATR RES, V60, P443, DOI 10.1203/01.pdr.0000238302.84552.d0
   Williams EC, 2014, HUM MOL GENET, V23, P2968, DOI 10.1093/hmg/ddu008
   Wu DF, 1999, P NATL ACAD SCI USA, V96, P254, DOI 10.1073/pnas.96.1.254
   Xinhua Bao, 2008, J Child Neurol, V23, P22, DOI 10.1177/0883073807307077
   Yan H, 2011, J ENDOCRINOL, V211, P27, DOI 10.1530/JOE-11-0200
   Yoshii A, 2003, P NATL ACAD SCI USA, V100, P1334, DOI 10.1073/pnas.0335785100
   Yoshii A, 2007, NAT NEUROSCI, V10, P702, DOI 10.1038/nn1903
   Yoshii A, 2010, DEV NEUROBIOL, V70, P304, DOI 10.1002/dneu.20765
   Zhou ZL, 2006, NEURON, V52, P255, DOI 10.1016/j.neuron.2006.09.037
NR 56
TC 5
Z9 7
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 8
PY 2014
VL 111
IS 27
BP 9941
EP 9946
DI 10.1073/pnas.1311685111
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK6CH
UT WOS:000338514800056
PM 24958891
ER

PT J
AU Wesseling, H
   Guest, PC
   Lee, CM
   Wong, EHF
   Rahmoune, H
   Bahn, S
AF Wesseling, Hendrik
   Guest, Paul C.
   Lee, Chi-Ming
   Wong, Erik H. F.
   Rahmoune, Hassan
   Bahn, Sabine
TI Integrative proteomic analysis of the NMDA NR1 knockdown mouse model
   reveals effects on central and peripheral pathways associated with
   schizophrenia and autism spectrum disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE ApoA1; Glutamate; Leptin; Major depressive disorder; Oligodendrocytes;
   Proteomics; Serum biomarkers; SRMstats
ID GROWTH-FACTOR-I; HIPPOCAMPAL SYNAPTIC PLASTICITY; KINASE SUBSTRATE
   MARCKS; PHENCYCLIDINE RAT MODEL; APOLIPOPROTEIN-A-I;
   CEREBROSPINAL-FLUID; RECEPTOR FUNCTION; ANTIPSYCHOTIC-DRUGS; BRAIN
   ABNORMALITIES; PREFRONTAL CORTEX
AB Background: Over the last decade, the transgenic N-methyl-D-aspartate receptor (NMDAR) NR1-knockdown mouse (NR1(neo-/-)) has been investigated as a glutamate hypofunction model for schizophrenia. Recent research has now revealed that the model also recapitulates cognitive and negative symptoms in the continuum of other psychiatric diseases, particularly autism spectrum disorders (ASD). As previous studies have mostly focussed on behavioural readouts, a molecular characterisation of this model will help to identify novel biomarkers or potential drug targets.
   Methods: Here, we have used multiplex immunoassay analyses to investigate peripheral analyte alterations in serum of NR1(neo-/-) mice, as well as a combination of shotgun label-free liquid chromatography mass spectrometry, bioinformatic pathway analyses, and a shotgun-based 40-plex selected reaction monitoring (SRM) assay to investigate altered molecular pathways in the frontal cortex and hippocampus. All findings were cross compared to identify translatable findings between the brain and periphery.
   Results: Multiplex immunoassay profiling led to identification of 29 analytes that were significantly altered in sera of NR1(neo-/-) mice. The highest magnitude changes were found for neurotrophic factors (VEGFA, EGF, IGF-1), apolipoprotein A1, and fibrinogen. We also found decreased levels of several chemokines. Following this, LC-MSE profiling led to identification of 48 significantly changed proteins in the frontal cortex and 41 in the hippocampus. In particular, MARCS, the mitochondrial pyruvate kinase, and CamKII-alpha were affected. Based on the combination of protein set enrichment and bioinformatic pathway analysis, we designed orthogonal SRM-assays which validated the abnormalities of proteins involved in synaptic long-term potentiation, myelination, and the ERK-signalling pathway in both brain regions. In contrast, increased levels of proteins involved in neurotransmitter metabolism and release were found only in the frontal cortex and abnormalities of proteins involved in the purinergic system were found exclusively in the hippocampus.
   Conclusions: Taken together, this multi-platform profiling study has identified peripheral changes which are potentially linked to central alterations in synaptic plasticity and neuronal function associated with NMDAR-NR1 hypofunction. Therefore, the reported proteomic changes may be useful as translational biomarkers in human and rodent model drug discovery efforts.
C1 [Wesseling, Hendrik; Guest, Paul C.; Rahmoune, Hassan; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT, England.
   [Lee, Chi-Ming; Wong, Erik H. F.] AstraZeneca, Wilmington, DE 19850 USA.
   [Bahn, Sabine] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands.
RP Bahn, S (reprint author), Univ Cambridge, Dept Chem Engn & Biotechnol, Tennis Court Rd, Cambridge CB2 1QT, England.
EM sb209@cam.ac.uk
FU Stanley Medical Research Institute (SMRI); Innovative Medicines
   Initiative for Novel Methods leading to New Medications in Depression
   and Schizophrenia (IMI NEWMEDS); Dutch Fund for Economic Structure
   Reinforcement [0908]; Autism Speaks grant [6009]
FX This research was kindly supported by the Stanley Medical Research
   Institute (SMRI), the Innovative Medicines Initiative for Novel Methods
   leading to New Medications in Depression and Schizophrenia (IMI
   NEWMEDS), the Dutch Fund for Economic Structure Reinforcement ((#0908)
   the NeuroBasic PharmaPhenomics project), and the Autism Speaks grant
   (#6009). Additional information is available at Molecular Autism's
   website.
CR Ahmed MR, 2008, J PHARMACOL EXP THER, V325, P276, DOI 10.1124/jpet.107.131987
   Alexa A, 2006, BIOINFORMATICS, V22, P1600, DOI 10.1093/bioinformatics/btl140
   Ashburner M, 2000, NAT GENET, V25, P25
   Bateman RH, 2002, J AM SOC MASS SPECTR, V13, P792, DOI 10.1016/S1044-0305(02)00420-8
   Bayes-Genis A, 2000, CIRC RES, V86, P125
   Beherec L, 2011, J CLIN PSYCHOPHARM, V31, P341, DOI 10.1097/JCP.0b013e318218f4a1
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Bickel S, 2008, NEUROPSYCHOPHARMACOL, V33, P1680, DOI 10.1038/sj.npp.1301536
   Billingslea EN, 2014, NEUROPSYCHOPHARMACOL, V39, P1603, DOI 10.1038/npp.2014.7
   Bodarky CL, 2009, J PHARMACOL EXP THER, V331, P308, DOI 10.1124/jpet.109.150938
   Bozdagi O, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-9
   BROEK JA, 2013, INT J NEUROPSYCHOPH, V17, P651
   Brun CC, 2009, HUM BRAIN MAPP, V30, P3887, DOI 10.1002/hbm.20814
   Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
   Calabrese B, 2005, NEURON, V48, P77, DOI 10.1016/j.neuron.2005.08.027
   Chan MK, 2011, INT REV NEUROBIOL, V101, P95, DOI 10.1016/B978-0-12-387718-5.00005-5
   Chang CY, 2012, MOL CELL PROTEOMICS, V11
   Clough T, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-S16-S6
   Cussac D, 2002, PSYCHOPHARMACOLOGY, V162, P168, DOI 10.1007/s00213-002-1043-0
   DANG YH, 2014, CURR PHARM IN PRESS
   DAVIS E, 1992, J NATL MED ASSOC, V84, P315
   Duffney LJ, 2013, J NEUROSCI, V33, P15767, DOI 10.1523/JNEUROSCI.1175-13.2013
   Duncan GE, 2004, BEHAV BRAIN RES, V153, P507, DOI 10.1016/j.bbr.2004.01.008
   Duncan GE, 2010, BRAIN RES, V1307, P166, DOI 10.1016/j.brainres.2009.10.023
   DUNCAN ID, 1992, J NEUROCYTOL, V21, P870, DOI 10.1007/BF01191684
   Dzirasa K, 2009, J NEUROSCI, V29, P8215, DOI 10.1523/JNEUROSCI.1773-09.2009
   Eack SM, 2013, SCHIZOPHR RES, V148, P24, DOI 10.1016/j.schres.2013.05.013
   Eastwood SL, 1997, BIOL PSYCHIAT, V41, P636, DOI 10.1016/S0006-3223(96)00220-X
   Engel SR, 2009, MOL PSYCHIATR, V14, P448, DOI 10.1038/sj.mp.4002135
   ERESHEFSKY L, 1989, CLIN PHARMACY, V8, P691
   Ernst A, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.42
   Ernst A, 2012, J PROTEOME RES, V11, P3704, DOI 10.1021/pr300197d
   Falcon S, 2007, BIOINFORMATICS, V23, P257, DOI 10.1093/bioinformatics/btl567
   Farrah T, 2011, MOL CELL PROTEOMICS, V10, DOI 10.1074/mcp.M110.006353
   Fumagalli F, 2006, MOL PHARMACOL, V69, P1366, DOI 10.1124/mol.105.019828
   Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031
   Gandal MJ, 2012, GENES BRAIN BEHAV, V11, P740, DOI 10.1111/j.1601-183X.2012.00816.x
   Gandal MJ, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.69
   GINGRICH JA, 1993, ANNU REV NEUROSCI, V16, P299, DOI 10.1146/annurev.ne.16.030193.001503
   Graber S, 2004, NEUROPHARMACOLOGY, V47, P706, DOI 10.1016/j.neuropharm.2004.08.004
   Halene TB, 2009, GENES BRAIN BEHAV, V8, P661, DOI 10.1111/j.1601-183X.2009.00504.x
   Hao YL, 2004, J NEUROSCI, V24, P6590, DOI 10.1523/JNEUROSCI.5747-03.2004
   HARTWIG JH, 1992, NATURE, V356, P618, DOI 10.1038/356618a0
   Horder J, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.53
   Huang JTJ, 2008, MOL PSYCHIATR, V13, P1118, DOI 10.1038/sj.mp.4002108
   HYTTEL J, 1978, PSYCHOPHARMACOLOGY, V59, P211, DOI 10.1007/BF00426624
   Inoue K, 1996, PROG NEUROBIOL, V50, P483, DOI 10.1016/S0301-0082(96)00037-8
   Krishnamurthy D, 2011, PROTEOMICS, V11, P495, DOI 10.1002/pmic.201000496
   Kyosseva SV, 2004, PROG NEURO-PSYCHOPH, V28, P997, DOI 10.1016/j.pnpbp.2004.05.017
   La YJ, 2007, J NEURAL TRANSM, V114, P657, DOI 10.1007/s00702-006-0607-2
   LAHTI AC, 1995, NEUROPSYCHOPHARMACOL, V13, P9, DOI 10.1016/0893-133X(94)00131-I
   Lange V, 2008, MOL CELL PROTEOMICS, V7, P1489, DOI 10.1074/mcp.M800032-MCP200
   Lanz TA, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-45
   Lara DR, 2006, PROG NEURO-PSYCHOPH, V30, P617, DOI 10.1016/j.pnpbp.2006.02.002
   Le Feuvre RA, 2003, J CEREBR BLOOD F MET, V23, P381, DOI 10.1097/01.WCB.0000048519.34839.97
   LENOX RH, 1996, J CLIN PSYCHIAT S13, V57, P32
   Lenox RH, 1996, J CLIN PSYCHIAT, V57, P23
   Lewis TL, 2010, J BIOL CHEM, V285, P36958, DOI 10.1074/jbc.M110.127829
   Lindahl JS, 2008, BRAIN RES, V1234, P137, DOI 10.1016/j.brainres.2008.06.126
   Lu P, 2007, NAT BIOTECHNOL, V25, P117, DOI 10.1038/nbt1270
   Lu XH, 2005, J MOL NEUROSCI, V27, P43, DOI 10.1385/JMN:27:01:43
   MacLean B, 2010, BIOINFORMATICS, V26, P966, DOI 10.1093/bioinformatics/btq054
   Martinez-Cengotitabengoa M, 2012, SCHIZOPHR RES, V137, P66, DOI 10.1016/j.schres.2012.03.004
   McNamara RK, 2005, HIPPOCAMPUS, V15, P675, DOI 10.1002/hipo.20089
   Meissirel C, 2011, P NATL ACAD SCI USA, V108, P13782, DOI 10.1073/pnas.1100341108
   Miyamoto S, 2005, MOL PSYCHIATR, V10, P79, DOI 10.1038/sj.mp.4001556
   Moghaddam B, 2002, BIOL PSYCHIAT, V51, P775, DOI 10.1016/S0006-3223(01)01362-2
   Mohn AR, 1999, CELL, V98, P427, DOI 10.1016/S0092-8674(00)81972-8
   MRTINSDESOUZA D, 2007, BRIEF FUNCT GENOMICS, V6, P70
   Naviaux RK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057380
   Niciu MJ, 2013, J NEURAL TR IN PRESS
   Oberg AL, 2009, J PROTEOME RES, V8, P2144, DOI 10.1021/pr8010099
   O'Kusky JR, 2000, J NEUROSCI, V20, P8435
   Palomino A, 2013, PROG NEURO-PSYCHOPH, V44, P29, DOI 10.1016/j.pnpbp.2013.01.008
   Pan CP, 2009, MOL CELL PROTEOMICS, V8, P443, DOI 10.1074/mcp.M800258-MCP200
   Pankratov YV, 2002, J NEUROSCI, V22, P8363
   PAPALEO F, 2011, NEUROPHARMACOLOGY, V62, P1204
   Pedrazza EL, 2007, NEUROSCI LETT, V413, P21, DOI 10.1016/j.neulet.2006.11.023
   Pereira A., 2011, INT J NEUROPSYCHOPH, V15, P1149
   Pereira A, 2009, J MOL NEUROSCI, V39, P185, DOI 10.1007/s12031-009-9188-5
   PICOTTI P, 2009, NAT METHODS, V7, P43
   Pozzi L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0083879
   Purcell AE, 2001, NEUROLOGY, V57, P1618
   Ralhan R, 2011, PROTEOMICS, V11, P2363, DOI 10.1002/pmic.201000186
   Riikonen R, 2006, CHEMOTHERAPY, V52, P279, DOI 10.1159/000095957
   Riikonen R, 2006, DEV MED CHILD NEUROL, V48, P751, DOI 10.1017/S0012162206001605
   Rossignol DA, 2011, MOL PSYCHIATR, V17, P290
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   SAID CP, 2012, VISION RES, V77, P59
   Satoh Y, 2011, J NEUROSCI, V31, P11953, DOI 10.1523/JNEUROSCI.2349-11.2011
   Saunders John A, 2013, Autism Res, V6, P69, DOI 10.1002/aur.1264
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Schwarz E, 2011, MOL PSYCHIATR, V17, P494, DOI DOI 10.1038/MP.2011.42
   Shanley LJ, 2001, J NEUROSCI, V21, part. no.
   Shcheglovitov A, 2013, NATURE, V503, P267, DOI 10.1038/nature12618
   SHEU FS, 1993, P NATL ACAD SCI USA, V90, P2705, DOI 10.1073/pnas.90.7.2705
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Steeb H, 2014, MOL AUTISM, V5, DOI 10.1186/2040-2392-5-4
   Steinman G, 2013, MED HYPOTHESES, V81, P21, DOI 10.1016/j.mehy.2013.03.034
   Stone JM, 2007, J PSYCHOPHARMACOL, V21, P440, DOI 10.1177/0269881106073126
   Sturn A, 2002, BIOINFORMATICS, V18, P207, DOI 10.1093/bioinformatics/18.1.207
   Tamminga CA, 1998, CRIT REV NEUROBIOL, V12, P21
   THAM A, 1993, J NEURAL TRANSM-PARK, V5, P165, DOI 10.1007/BF02257671
   Tkachev D, 2003, LANCET, V362, P798, DOI 10.1016/S0140-6736(03)14289-4
   Valjent E, 2005, P NATL ACAD SCI USA, V102, P491, DOI 10.1073/pnas.0408305102
   Vanhala R, 2001, DEV MED CHILD NEUROL, V43, P614, DOI 10.1017/S0012162201001116
   Venkatasubramanian G, 2007, AM J PSYCHIAT, V164, P1557, DOI 10.1176/appi.ajp.2007.07020233
   Venkatasubramanian G, 2010, SCHIZOPHR RES, V119, P131, DOI 10.1016/j.schres.2010.01.033
   Weickert CS, 2012, MOL PSYCHIATR, DOI [10.1038/mp.2012.137, DOI 10.1038/MP.2012.137]
   Wesseling H, 2013, NEUROPSYCHOPHARMACOL, V38, P2532, DOI 10.1038/npp.2013.160
   WETIE AGN, 2014, ELECTROPHOR IN PRESS
   Yang J, 2011, MOL PSYCHIATR, V18, P67, DOI DOI 10.1038/MP.2011.131
   Yang K, 2011, GENES BRAIN BEHAV, V10, P834, DOI 10.1111/j.1601-183X.2011.00723.x
   Yang SZ, 2013, DEVELOPMENT, V140, P4554, DOI 10.1242/dev.098145
   Yang X, 2011, PROTEOMICS, V11, P501, DOI 10.1002/pmic.201000525
   YUAN P, 2009, J AFFECT DISORDERS, V124, P164
   Zachary I, 2005, NEUROSIGNALS, V14, P207, DOI 10.1159/000088637
   Zhan Y, 2014, NAT NEUROSCI, V17, P400, DOI 10.1038/nn.3641
   Zhang Y., 2011, MOL CELL PROTEOMICS, V10
NR 119
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUL 4
PY 2014
VL 5
AR 38
DI 10.1186/2040-2392-5-38
PG 17
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AM0YX
UT WOS:000339574700001
PM 25061506
ER

PT J
AU Kushki, A
   Brian, J
   Dupuis, A
   Anagnostou, E
AF Kushki, Azadeh
   Brian, Jessica
   Dupuis, Annie
   Anagnostou, Evdokia
TI Functional autonomic nervous system profile in children with autism
   spectrum disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; Autonomic nervous system; Heart rate;
   Respiratory sinus arrhythmia
ID RESPIRATORY SINUS ARRHYTHMIA; HEART-RATE-VARIABILITY;
   ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ASPERGER-SYNDROME; SUSTAINED
   ATTENTION; ANXIETY DISORDERS; RESPONSE-INHIBITION; REVISED VERSION;
   SOCIAL ANXIETY; AMYGDALA
AB Background: Autonomic dysregulation has been recently reported as a feature of autism spectrum disorder (ASD). However, the nature of autonomic atypicalities in ASD remain largely unknown. The goal of this study was to characterize the cardiac autonomic profile of children with ASD across four domains affected in ASD (anxiety, attention, response inhibition, and social cognition), and suggested to be affected by autonomic dysregulation.
   Methods: We compared measures of autonomic cardiac regulation in typically developing children (n = 34) and those with ASD (n = 40) as the children performed tasks eliciting anxiety, attention, response inhibition, and social cognition. Heart rate was used to quantify overall autonomic arousal, and respiratory sinus arrhythmia (RSA) was used as an index of vagal influences. Associations between atypical autonomic findings and intellectual functioning (Weschler scale), ASD symptomatology (Social Communication Questionnaire score), and co-morbid anxiety (Revised Children's Anxiety and Depression Scale) were also investigated.
   Results: The ASD group had marginally elevated basal heart rate, and showed decreased heart rate reactivity to social anxiety and increased RSA reactivity to the social cognition task. In this group, heart rate reactivity to the social anxiety task was positively correlated with IQ and task performance, and negatively correlated with generalized anxiety. RSA reactivity in the social cognition task was positively correlated with IQ.
   Conclusions: Our data suggest overall autonomic hyperarousal in ASD and selective atypical reactivity to social tasks.
C1 [Kushki, Azadeh; Brian, Jessica; Anagnostou, Evdokia] Bloorview Res Inst, Toronto, ON M4G 1R8, Canada.
   [Kushki, Azadeh] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada.
   [Dupuis, Annie] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
RP Kushki, A (reprint author), Bloorview Res Inst, 150 Kilgour Rd, Toronto, ON M4G 1R8, Canada.
EM akushki@hollandbloorview.ca
FU Ontario government
FX This research was conducted with the support of the Ontario Brain
   Institute, an independent non-profit corporation, funded partially by
   the Ontario government. The opinions, results, and conclusions are those
   of the authors, and no endorsement by the Ontario Brain Institute is
   intended or should be inferred. We would like to thank Krissy
   Doyle-Thomas, Seth Sobel, Danielle D'Alessandro, Tom Nantis, Susan Day
   Fragiadakis, Naomi Sklar, and Johnny Au for their contributions to the
   study.
CR Adams NC, 2009, J AUTISM DEV DISORD, V39, P1112, DOI 10.1007/s10803-009-0721-8
   Anagnostou E., 2011, MOL AUTISM, V2
   Appelhans BM, 2006, REV GEN PSYCHOL, V10, P229, DOI 10.1037/1089-2680.10.3.229
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   BEATTY MJ, 1991, HUM COMMUN RES, V18, P147, DOI 10.1111/j.1468-2958.1991.tb00542.x
   Beauchaine TP, 2001, J ABNORM PSYCHOL, V110, P610, DOI 10.1037/0021-843X.110.4.610
   BEHNKE RR, 1971, SPEECH MONOGR, V38, P65
   Beidel D., 2013, CHILD ANXIETY DISORD
   Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
   Benevides TW, 2013, J AUTISM DEV DISORD, P1
   Billman GE, 2013, FRONT PHYSIOL, V4, P1, DOI DOI 10.3389/FPHYS.2013.00026)
   Borger N, 1999, J ABNORM CHILD PSYCH, V27, P25, DOI 10.1023/A:1022610306984
   Boutcher YN, 2006, BIOL PSYCHOL, V73, P235, DOI 10.1016/j.biopsycho.2006.04.005
   Cath DC, 2008, PSYCHOPATHOLOGY, V41, P101, DOI 10.1159/000111555
   Cheshire WP, 2012, AUTON NEUROSCI-BASIC, V171, P4, DOI 10.1016/j.autneu.2012.08.003
   Coull JT, 1996, NEUROPSYCHOLOGIA, V34, P1085, DOI 10.1016/0028-3932(96)00029-2
   Crowell SE, 2006, J ABNORM PSYCHOL, V115, P174, DOI 10.1037/0021-843X.115.1.174
   Ebesutani C, 2010, J ABNORM CHILD PSYCH, V38, P249, DOI 10.1007/s10802-009-9363-8
   Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
   Fechir M, 2010, NEUROIMAGE, V50, P847, DOI 10.1016/j.neuroimage.2009.12.004
   Friedman BH, 1998, J PSYCHOSOM RES, V44, P133, DOI 10.1016/S0022-3999(97)00202-X
   Graziano P, 2013, BIOL PSYCHOL, V94, P22, DOI 10.1016/j.biopsycho.2013.04.011
   HAMILTON PS, 1986, IEEE T BIO-MED ENG, V33, P1157, DOI 10.1109/TBME.1986.325695
   Jansen LMC, 2003, NEUROPSYCHOPHARMACOL, V28, P582, DOI 10.1038/sj.npp.1300046
   Jansen LMC, 2006, J AUTISM DEV DISORD, V36, P891, DOI 10.1007/s10803-006-0124-z
   Jennings JR, 1997, DEV PSYCHOL, V33, P308, DOI 10.1037/0012-1649.33.2.308
   Juranek J, 2006, J CHILD NEUROL, V21, P1051, DOI 10.2310/7010.2006.00237
   Kaland N, 2008, J AUTISM DEV DISORD, V38, P1112, DOI 10.1007/s10803-007-0496-8
   KAWACHI I, 1995, AM J CARDIOL, V75, P882, DOI 10.1016/S0002-9149(99)80680-8
   Kerns CM, 2012, CLIN PSYCHOL-SCI PR, V19, P323, DOI 10.1111/cpsp.12009
   Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
   Kushki A, 2013, PLOS ONE, V8, P59730
   Lang PJ, 1968, 3 C RES PSYCH 3 MAY, P90
   Levine TP, 2012, RES AUTISM SPECT DIS, V6, P177, DOI 10.1016/j.rasd.2011.04.003
   Lewis GF, 2012, BIOL PSYCHOL, V89, P349, DOI 10.1016/j.biopsycho.2011.11.009
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mathew SJ, 2008, AM J MED GENET C, V148C, P89, DOI 10.1002/ajmg.c.30172
   McAuley T, 2014, J CHILD PSYCHOL PSYC, V55, P292, DOI 10.1111/jcpp.12160
   Mezzacappa E, 1997, J CHILD PSYCHOL PSYC, V38, P457, DOI 10.1111/j.1469-7610.1997.tb01531.x
   Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
   Ming X, 2005, BRAIN DEV-JPN, V27, P509, DOI 10.1016/j.braindev.2005.01.003
   Murphy CM, 2012, AUTISM RES, V5, P3, DOI 10.1002/aur.227
   Neuhaus E, 2014, J AUTISM DEV DISORD, V44, P730, DOI 10.1007/s10803-013-1923-7
   Nordahl CW, 2012, ARCH GEN PSYCHIAT, V69, P53, DOI 10.1001/archgenpsychiatry.2011.145
   PAN J, 1985, IEEE T BIO-MED ENG, V32, P230, DOI 10.1109/TBME.1985.325532
   Parellada M, 2014, EUR PSYCHIAT, V29, P11, DOI 10.1016/j.eurpsy.2013.02.005
   Patriquin MA, 2013, DEV PSYCHOBIOL, V55, P101, DOI 10.1002/dev.21002
   Patriquin MA, 2013, APPL PSYCHOPHYS BIOF, V38, P203, DOI 10.1007/s10484-013-9225-6
   Porges S. W., 2011, POLYVAGAL THEORY NEU
   Porges S. W., 1985, United States Patent, Patent No. [4,510,944, 4510944]
   PORGES SW, 1992, ATTENTION AND INFORMATION PROCESSING IN INFANTS AND ADULTS, P201
   Porges SW, 2013, INT J PSYCHOPHYSIOL, V88, P261, DOI 10.1016/j.ijpsycho.2012.11.009
   Porhola M, 2002, COMMUN EDUC, V51, P420, DOI 10.1080/03634520216527
   Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
   Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
   Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007
   Shin LM, 2010, NEUROPSYCHOPHARMACOL, V35, P169, DOI 10.1038/npp.2009.83
   Smeekens I., 2013, J AUTISM DEV DISORD, P1
   Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/h0054651
   SUESS PE, 1994, PSYCHOPHYSIOLOGY, V31, P17, DOI 10.1111/j.1469-8986.1994.tb01020.x
   Task Force of the European Society of Cardiology and North American Society of Pacing and Electrophysiology, 1996, CIRCULATION, V93, P1043
   Thayer JF, 1996, BIOL PSYCHIAT, V39, P255, DOI 10.1016/0006-3223(95)00136-0
   TULEN JHM, 1989, PHARMACOL BIOCHEM BE, V32, P9, DOI 10.1016/0091-3057(89)90204-9
   Tyson KE, 2012, J AUTISM DEV DISORD, V42, P1477, DOI 10.1007/s10803-011-1386-7
   Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   van Steensel FJA, 2013, J AUTISM DEV DISORD, V43, P361, DOI 10.1007/s10803-012-1575-z
   Verbruggen F, 2009, NEUROSCI BIOBEHAV R, V33, P647, DOI 10.1016/j.neubiorev.2008.08.014
   Watson LR, 2012, J AUTISM DEV DISORD, V42, P1616, DOI 10.1007/s10803-011-1401-z
   Weiss LA, 2009, EXPERT REV MOL DIAGN, V9, P795, DOI [10.1586/erm.09.59, 10.1586/ERM.09.59]
NR 73
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUL 4
PY 2014
VL 5
AR 39
DI 10.1186/2040-2392-5-39
PG 10
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AL4AS
UT WOS:000339075800001
PM 25031832
ER

PT J
AU Keita, L
   Guy, J
   Berthiaume, C
   Mottron, L
   Bertone, A
AF Keita, Luc
   Guy, Jacalyn
   Berthiaume, Claude
   Mottron, Laurent
   Bertone, Armando
TI An early origin for detailed perception in Autism Spectrum Disorder:
   biased sensitivity for high-spatial frequency information.
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FUNCTIONING INDIVIDUALS; VISUAL-ACUITY; CONTRAST SENSITIVITY; GABA
   CONCENTRATION; ASPERGER-SYNDROME; DISCRIMINATION; CORTEX; BRAIN;
   PERFORMANCE; MECHANISMS
AB Autistics demonstrate superior performances on several visuo-spatial tasks where local or detailed information processing is advantageous. Altered spatial filtering properties at an early level of visuo-spatial analysis may be a plausible perceptual origin for such detailed perception in Autism Spectrum Disorder. In this study, contrast sensitivity for both luminance and texture-defined vertically-oriented sine-wave gratings were measured across a range of spatial frequencies (0.5, 1, 2, 4 & 8 cpd) for autistics and non-autistic participants. Contrast sensitivity functions and peak frequency ratios were plotted and compared across groups. Results demonstrated that autistic participants were more sensitivity to luminance-defined, high spatial frequency gratings (8 cpd). A group difference in peak distribution was also observed as 35% of autistic participants manifested peak sensitivity for luminance-defined gratings of 4 cpd, compared to only 7% for the comparison group. These findings support that locally-biased perception in Autism Spectrum Disorder originates, at least in part, from differences in response properties of early spatial mechanisms favouring detailed spatial information processing.
C1 [Keita, Luc] Univ Montreal, Ctr Rech Neuropsychol & Cognit CERNEC, Montreal, PQ H3C 3J7, Canada.
   [Guy, Jacalyn; Bertone, Armando] McGill Univ, Perceptual Neurosci Lab Autism & Dev, Montreal, PQ H3A 2T5, Canada.
   [Guy, Jacalyn] McGill Univ, Integrated Program Neurosci, Montreal, PQ H3A 2T5, Canada.
   [Berthiaume, Claude; Mottron, Laurent; Bertone, Armando] Univ Montreal, Ctr Excellence Pervas Dev Disorders CETEDUM, Montreal, PQ H3C 3J7, Canada.
   [Berthiaume, Claude; Mottron, Laurent; Bertone, Armando] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.
   [Bertone, Armando] McGill Univ, Sch Appl Child Psychol, Dept Educ & Counselling Psychol, Montreal, PQ H3A 2T5, Canada.
RP Bertone, A (reprint author), McGill Univ, Perceptual Neurosci Lab Autism & Dev, Montreal, PQ H3A 2T5, Canada.
EM armando.bertone@mcgill.ca
FU Autism Speaks mentor-based fellowship; Canadian Institute for Health
   Research operating Grant
FX This study was supported by funding from an Autism Speaks mentor-based
   (L.M. and A.B.) fellowship to L.K. and a Canadian Institute for Health
   Research operating Grant to L.M. and A.B. We thank all the participants
   for their involvement in this project.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   [Anonymous], 1988, APPL MAN
   Bach M., 2009, BIOL PSYCHIAT, V66, pe23
   Bach Michael, 2009, Biol Psychiatry, V66, pe19, DOI 10.1016/j.biopsych.2009.02.035
   Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
   Bertone A, 2010, J AUTISM DEV DISORD, V40, P1541, DOI 10.1007/s10803-010-1110-z
   Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
   Bonnel A, 2010, NEUROPSYCHOLOGIA, V48, P2465, DOI 10.1016/j.neuropsychologia.2010.04.020
   Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65
   de Jonge MV, 2006, J AUTISM DEV DISORD, V36, P677, DOI 10.1007/s10803-006-0113-2
   Edden RAE, 2009, J NEUROSCI, V29, P15721, DOI 10.1523/JNEUROSCI.4426-09.2009
   Falkmer M, 2011, BIOL PSYCHIAT, V70, P812, DOI 10.1016/j.biopsych.2011.07.025
   Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
   Ferster D, 2000, ANNU REV NEUROSCI, V23, P441, DOI 10.1146/annurev.neuro.23.1.441
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Geoffray M. M., 2011, 10 ANN INT M AUT RES
   Grice SJ, 2001, NEUROREPORT, V12, P2697, DOI 10.1097/00001756-200108280-00021
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Harvey LO, 1997, SPATIAL VISION, V11, P121, DOI 10.1163/156856897X00159
   Jemel B, 2010, J VISION, V10, DOI 10.1167/10.6.13
   Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Keita L, 2011, BIOL PSYCHIAT, V70, P806, DOI 10.1016/j.biopsych.2011.07.031
   Keita L, 2010, AUTISM RES, V3, P333, DOI 10.1002/aur.164
   Koh HC, 2010, J AUTISM DEV DISORD, V40, P978, DOI 10.1007/s10803-010-0953-7
   KOTHE AC, 1990, OPTOMETRY VISION SCI, V67, P283, DOI 10.1097/00006324-199004000-00009
   Latham K, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-4
   Ledgeway T, 1997, VISION RES, V37, P215, DOI 10.1016/S0042-6989(96)00122-8
   Leonard HC, 2010, J EXP CHILD PSYCHOL, V106, P193, DOI 10.1016/j.jecp.2010.03.005
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Milne E, 2009, J AUTISM DEV DISORD, V39, P965, DOI 10.1007/s10803-009-0705-8
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Mottron L., 2001, ENHANCED PERCEPTUAL, P131
   Muller RA, 2008, ANN NY ACAD SCI, V1145, P300, DOI 10.1196/annals.1416.014
   Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
   Puts NAJ, 2011, J NEUROSCI, V31, P16556, DOI 10.1523/JNEUROSCI.4489-11.2011
   Razak KA, 2010, J NEUROPHYSIOL, V104, P517, DOI 10.1152/jn.00294.2010
   Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
   Samson F, 2012, HUM BRAIN MAPP, V33, P1553, DOI 10.1002/hbm.21307
   Snijders TM, 2013, NEUROIMAGE-CLIN, V3, P65, DOI 10.1016/j.nicl.2013.06.015
   Tavassoli T, 2011, VISION RES, V51, P1778, DOI 10.1016/j.visres.2011.06.004
   Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321
   Vlamings PHJM, 2010, BIOL PSYCHIAT, V68, P1107, DOI 10.1016/j.biopsych.2010.06.024
NR 50
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 4
PY 2014
VL 4
AR 5475
DI 10.1038/srep05475
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK5ZL
UT WOS:000338506000001
PM 24993026
ER

PT J
AU Troyb, E
   Rosenthal, M
   Eigsti, IM
   Kelley, E
   Tyson, K
   Orinstein, A
   Barton, M
   Fein, D
AF Troyb, Eva
   Rosenthal, Michael
   Eigsti, Inge-Marie
   Kelley, Elizabeth
   Tyson, Katherine
   Orinstein, Alyssa
   Barton, Marianne
   Fein, Deborah
TI Executive functioning in individuals with a history of ASDs who have
   achieved optimal outcomes
SO CHILD NEUROPSYCHOLOGY
LA English
DT Article
DE Outcome; Executive functioning; Optimal outcome; High-functioning
   autism; Autism
ID AUTISTIC-CHILDREN; FOLLOW-UP; BEHAVIORAL TREATMENT; SPECTRUM DISORDERS;
   ABOVE-AVERAGE; INTELLIGENCE; AGE; COMMUNICATION; INTERVENTION;
   PERFORMANCE
AB Executive functioning (EF) is examined among children and adolescents once diagnosed with an autism spectrum disorder (ASD), but who no longer meet diagnostic criteria. These individuals have average social and language skills, receive minimal school support and are considered to have achieved "optimal outcomes" (OOs). Since residual impairments in these individuals might be expected in deficits central to autism, and in developmentally advanced skills, EF was examined in 34 individuals who achieved OOs, 43 individuals with high-functioning autism (HFA), and 34 typically developing (TD) peers. Groups were matched on age (M = 13.49), gender, and nonverbal IQ (NVIQ) but differed on verbal IQ (VIQ; HFA < TD, OO). On direct assessment, all three groups demonstrated average EF; however, the OO and HFA groups exhibited more impulsivity and less efficient planning and problem-solving than the TD group, and more HFA participants exhibited below average inhibition than did OO and TD participants. Parent-report measures revealed average EF among the OO and TD groups; however, the OO group exhibited more difficulty than the TD group on set-shifting and working memory. HFA participants demonstrated more difficulty on all parent-reported EF domains, with a clinical impairment in attention-shifting. Results suggest that EF in OO appears to be within the average range, even for functions that were impaired among individuals with HFA. Despite their average performance, however, the OO and TD groups differed on measures of impulsivity, set-shifting, problem-solving, working memory, and planning, suggesting that the OO group does not have the above-average EF scores of the TD group despite their high-average IQs.
C1 [Troyb, Eva; Eigsti, Inge-Marie; Tyson, Katherine; Orinstein, Alyssa; Barton, Marianne; Fein, Deborah] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
   [Rosenthal, Michael] Child Mind Inst, New York, NY USA.
   [Kelley, Elizabeth] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
   [Fein, Deborah] Univ Connecticut, Dept Pediat, Farmington, CT USA.
RP Troyb, E (reprint author), Univ Connecticut, Dept Psychol, Unit 1020, 406 Babbidge Rd, Storrs, CT 06269 USA.
EM eva.troyb@uconn.edu
CR Ardila A, 2000, ARCH CLIN NEUROPSYCH, V15, P31, DOI 10.1016/S0887-6177(98)00159-0
   Arffa S, 2007, ARCH CLIN NEUROPSYCH, V22, P969, DOI 10.1016/j.acn.2007.08.001
   ARFFA S, 1998, ARCH CLIN NEUROPSYCH, V13, P713, DOI 10.1016/S0887-6177(98)00007-9
   Baron IS, 2004, NEUROPSYCHOLOGICAL E
   Cohen H., 2007, DEV BEHAV PEDIAT, V27, pS145, DOI 10.1097/00004703-200604002-00013
   DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777
   Delis DC, 2001, DELIS KAPLAN EXECUTI
   Eigsti I. M., 2011, NEUROPSYCHOLOGY AUTI, P185
   Fein D, 2005, J AUTISM DEV DISORD, V35, P525, DOI 10.1007/s10803-005-5066-3
   Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037
   Gioia GA, 2000, BEHAV RATING INVENTO
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   HOLM S, 1979, SCAND J STAT, V6, P65
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Kelley E, 2010, RES AUTISM SPECT DIS, V4, P526, DOI 10.1016/j.rasd.2009.12.001
   Kelley E, 2006, J AUTISM DEV DISORD, V36, P807, DOI 10.1007/s10803-006-0111-4
   Kenworthy LE, 2005, DEV NEUROPSYCHOL, V28, P809, DOI 10.1207/s15326942dn2803_4
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Landa RJ, 2005, J AUTISM DEV DISORD, V35, P557, DOI 10.1007/s10803-005-0001-1
   VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   Luyster R, 2005, DEV NEUROPSYCHOL, V27, P311, DOI 10.1207/s15326942dn2703_2
   Mahone EM, 2002, ARCH CLIN NEUROPSYCH, V17, P643, DOI 10.1016/S0887-6177(01)00168-8
   MUNDY P, 1993, AM J MENT RETARD, V97, P381
   O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
   RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Schuh J. M., BEHAV SCI IN PRESS
   Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
   Sigman M., 1999, MONOGRAPHS SOC RES C, V256, P64
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Stevens J, 1996, APPL MULTIVARIATE ST
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   SZATMARI P, 1990, J AM ACAD CHILD PSY, V29, P130, DOI 10.1097/00004583-199001000-00021
   SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842
   Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weiss MJ, 1999, BEHAV INTERVENT, V14, P3, DOI 10.1002/(SICI)1099-078X(199901/03)14:1<3::AID-BIN25>3.0.CO;2-F
   Zachor DA, 2007, RES AUTISM SPECT DIS, V1, P304, DOI 10.1016/j.rasd.2006.12.001
NR 44
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0929-7049
EI 1744-4136
J9 CHILD NEUROPSYCHOL
JI Child Neuropsychol.
PD JUL 4
PY 2014
VL 20
IS 4
BP 378
EP 397
DI 10.1080/09297049.2013.799644
PG 20
WC Clinical Neurology
SC Neurosciences & Neurology
GA AF8VA
UT WOS:000334992500001
PM 23731181
ER

PT J
AU Rothwell, PE
   Fuccillo, MV
   Maxeiner, S
   Hayton, SJ
   Gokce, O
   Lim, BK
   Fowler, SC
   Malenka, RC
   Sudhof, TC
AF Rothwell, Patrick E.
   Fuccillo, Marc V.
   Maxeiner, Stephan
   Hayton, Scott J.
   Gokce, Ozgun
   Lim, Byung Kook
   Fowler, Stephen C.
   Malenka, Robert C.
   Suedhof, Thomas C.
TI Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal
   Circuits to Boost Repetitive Behaviors
SO CELL
LA English
DT Article
ID NUCLEUS-ACCUMBENS; SYNAPTIC PATHOPHYSIOLOGY; BASAL GANGLIA; SOCIAL
   REWARD; MOUSE MODEL; DE-NOVO; MICE; PLASTICITY; SKILL; ACQUISITION
AB In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the corresponding mutations produce robust synaptic and behavioral changes. However, different neuroligin-3 mutations cause largely distinct phenotypes in mice, and no causal relationship links a specific synaptic dysfunction to a behavioral change. Using rotarod motor learning as a proxy for acquired repetitive behaviors in mice, we found that different neuroligin-3 mutations uniformly enhanced formation of repetitive motor routines. Surprisingly, neuroligin-3 mutations caused this phenotype not via changes in the cerebellum or dorsal striatum but via a selective synaptic impairment in the nucleus accumbens/ventral striatum. Here, neuroligin-3 mutations increased rotarod learning by specifically impeding synaptic inhibition onto D1-dopamine receptor-expressing but not D2-dopamine receptor-expressing medium spiny neurons. Our data thus suggest that different autism-associated neuroligin-3 mutations cause a common increase in acquired repetitive behaviors by impairing a specific striatal synapse and thereby provide a plausible circuit substrate for autism pathophysiology.
C1 [Rothwell, Patrick E.; Fuccillo, Marc V.; Maxeiner, Stephan; Gokce, Ozgun; Suedhof, Thomas C.] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA.
   [Rothwell, Patrick E.; Fuccillo, Marc V.; Hayton, Scott J.; Lim, Byung Kook; Malenka, Robert C.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA.
   [Suedhof, Thomas C.] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA.
   [Fowler, Stephen C.] Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA.
RP Malenka, RC (reprint author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA.
EM malenka@stanford.edu; tcs1@stanford.edu
FU NIMH [P50 MH086403, K99 MH099243, F32 MH096491]; Simons Foundation
FX We thank A. Darvishzadeh, A. Afjei, G. Sun, S. Ghosh, and N. Huang for
   technical assistance, C. Foldy for advice, and all Malenka and Sudhof
   lab members for helpful discussions. This work was supported by grants
   from the NIMH (P50 MH086403 to R.C.M. and T.C.S., K99 MH099243 to
   M.V.F., and F32 MH096491 to P.E.R.); initial stages were also supported
   by the Simons Foundation (to R.C.M. and T.C.S.).
CR Akil H, 2010, SCIENCE, V327, P1580, DOI 10.1126/science.1188654
   Aoto J, 2013, CELL, V154, P75, DOI 10.1016/j.cell.2013.05.060
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Balleine BW, 2010, NEUROPSYCHOPHARMACOL, V35, P48, DOI 10.1038/npp.2009.131
   Bateup HS, 2013, NEURON, V78, P510, DOI 10.1016/j.neuron.2013.03.017
   Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159
   Belin D, 2008, NEURON, V57, P432, DOI 10.1016/j.neuron.2007.12.019
   Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22
   Comoletti D, 2004, J NEUROSCI, V24, P4889, DOI 10.1523/JNEUROSCI.0468-04.2004
   Costa RM, 2004, CURR BIOL, V14, P1124, DOI 10.1016/j.cub.2004.06.053
   Dang MT, 2006, P NATL ACAD SCI USA, V103, P15254, DOI 10.1073/pnas.0601758103
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Dolen G, 2013, NATURE, V501, P179, DOI 10.1038/nature12518
   Durieux PF, 2009, NAT NEUROSCI, V12, P393, DOI 10.1038/nn.2286
   Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Fishell G, 2011, ANNU REV NEUROSCI, V34, P535, DOI 10.1146/annurev-neuro-061010-113717
   Foldy C, 2013, NEURON, V78, P498, DOI 10.1016/j.neuron.2013.02.036
   Fowler SC, 2001, J NEUROSCI METH, V107, P107, DOI 10.1016/S0165-0270(01)00359-4
   Gerfen CR, 2011, ANNU REV NEUROSCI, V34, P441, DOI 10.1146/annurev-neuro-061010-113641
   Graybiel AM, 2008, ANNU REV NEUROSCI, V31, P359, DOI 10.1146/annurev.neuro.29.051605.112851
   Groenewegen HJ, 1996, PROG BRAIN RES, V107, P485
   Grueter BA, 2010, NAT NEUROSCI, V13, P1519, DOI 10.1038/nn.2685
   Haber SN, 2000, J NEUROSCI, V20, P2369
   Heiman M, 2008, CELL, V135, P738, DOI 10.1016/j.cell.2008.10.028
   Hikosaka O, 2002, CURR OPIN NEUROBIOL, V12, P217, DOI 10.1016/S0959-4388(02)00307-0
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   Howes SR, 2000, PSYCHOPHARMACOLOGY, V151, P55, DOI 10.1007/s002130000451
   Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kreitzer AC, 2008, NEURON, V60, P543, DOI 10.1016/j.neuron.2008.11.005
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lin CW, 2010, NEURON, V65, P32, DOI 10.1016/j.neuron.2009.12.001
   Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Presti MF, 2004, PHARMACOL BIOCHEM BE, V77, P501, DOI 10.1016/j.pbb.2003.12.004
   Rilling JK, 2002, NEURON, V35, P395, DOI 10.1016/S0896-6273(02)00755-9
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Trezza V, 2011, J NEUROSCI, V31, P6362, DOI 10.1523/JNEUROSCI.5492-10.2011
   Yin HH, 2006, NAT REV NEUROSCI, V7, P464, DOI 10.1038/nrn1919
   Yin HH, 2009, NAT NEUROSCI, V12, P333, DOI 10.1038/nn.2261
   Zoghbi H.Y., 2012, COLD SPRING HARB PER, V4, P4, DOI DOI 10.1101/CSHPERSPECT.A009886
NR 46
TC 14
Z9 14
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD JUL 3
PY 2014
VL 158
IS 1
BP 198
EP 212
DI 10.1016/j.cell.2014.04.045
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AN9QQ
UT WOS:000340943100018
PM 24995986
ER

PT J
AU Yoon, KJ
   Nguyen, HN
   Ursini, G
   Zhang, FY
   Kim, NS
   Wen, ZX
   Makri, G
   Nauen, D
   Shin, JH
   Park, Y
   Chung, R
   Pekle, E
   Zhang, C
   Towe, M
   Mohammed, S
   Hussaini, Q
   Lee, Y
   Rujescu, D
   St Clair, D
   Kleinman, JE
   Hyde, TM
   Krauss, G
   Christian, KM
   Rapoport, JL
   Weinberger, DR
   Song, HJ
   Ming, GL
AF Yoon, Ki-Jun
   Ha Nam Nguyen
   Ursini, Gianluca
   Zhang, Fengyu
   Kim, Nam-Shik
   Wen, Zhexing
   Makri, Georgia
   Nauen, David
   Shin, Joo Heon
   Park, Youngbin
   Chung, Raeeun
   Pekle, Eva
   Zhang, Ce
   Towe, Maxwell
   Mohammed, Syed
   Hussaini, Qasim
   Lee, Yohan
   Rujescu, Dan
   St Clair, David
   Kleinman, Joel E.
   Hyde, Thomas M.
   Krauss, Gregory
   Christian, Kimberly M.
   Rapoport, Judith L.
   Weinberger, Daniel R.
   Song, Hongjun
   Ming, Guo-li
TI Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals
   Neural Stem Cell Deficits Associated with Adherens Junctions and
   Polarity
SO CELL STEM CELL
LA English
DT Article
ID COPY NUMBER VARIANTS; RECURRENT MICRODELETIONS; NEURONAL MIGRATION;
   CEREBRAL-CORTEX; PROTEIN; AUTISM; DROSOPHILA; 15Q11.2; WAVE2;
   PATHOGENESIS
AB Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. First, we show that human iPSC-derived neural progenitors carrying 15q11.2 microdeletion exhibit deficits in adherens junctions and apical polarity. This results from haploinsufficiency of CYFIP1, a gene within 15q11.2 that encodes a subunit of the WAVE complex, which regulates cytoskeletal dynamics. In developing mouse cortex, deficiency in CYFIP1 and WAVE signaling similarly affects radial glial cells, leading to their ectopic localization outside of the ventricular zone. Finally, targeted human genetic association analyses revealed an epistatic interaction between CYFIP1 and WAVE signaling mediator ACTR2 and risk for schizophrenia. Our findings provide insight into how CYFIP1 regulates neural stem cell function and may contribute to the susceptibility of neuropsychiatric disorders.
C1 [Yoon, Ki-Jun; Ha Nam Nguyen; Kim, Nam-Shik; Wen, Zhexing; Makri, Georgia; Nauen, David; Park, Youngbin; Chung, Raeeun; Pekle, Eva; Zhang, Ce; Towe, Maxwell; Mohammed, Syed; Christian, Kimberly M.; Song, Hongjun; Ming, Guo-li] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA.
   [Yoon, Ki-Jun; Kim, Nam-Shik; Wen, Zhexing; Makri, Georgia; Zhang, Ce; Krauss, Gregory; Christian, Kimberly M.; Weinberger, Daniel R.; Song, Hongjun; Ming, Guo-li] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
   [Ha Nam Nguyen; Song, Hongjun; Ming, Guo-li] Johns Hopkins Univ, Sch Med, Grad Program Cellular & Mol Med, Baltimore, MD 21205 USA.
   [Ursini, Gianluca; Zhang, Fengyu; Shin, Joo Heon; Kleinman, Joel E.; Hyde, Thomas M.; Weinberger, Daniel R.] Johns Hopkins Univ, Sch Med, Lieber Inst Brain Dev, Baltimore, MD 21205 USA.
   [Nauen, David] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
   [Lee, Yohan; Rapoport, Judith L.] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
   [Rujescu, Dan] Univ Munich, Dept Psychiat, D-80336 Munich, Germany.
   [St Clair, David] Univ Aberdeen, Royal Cornhill Hosp, Aberdeen AB25 2ZD, Scotland.
   [Weinberger, Daniel R.; Song, Hongjun; Ming, Guo-li] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA.
RP Ming, GL (reprint author), Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA.
EM shongju1@jhmi.edu; gming1@jhmi.edu
RI Wen, Zhexing/B-9313-2014
FU NIH [NS048271, HD069184, NS047344, MH087874, F31MH102978]; Brain and
   Behavior Research Foundation (NARSAD); Maryland Stem Cell Research Fund
   (MSCRF); Simons Foundation Autism Research Initiative (SFARI);
   International Mental Health Research Organization (IMHRO); Lieber
   Institute for Brain Development; NARSAD; MSCRF; HFSP
FX We would like to thank members of G.-l.M. and H.S. laboratories for
   discussion, ICE stem cell core and H. Kim for generating some iPSC
   lines, K. Ahn, T. Andersen, V. Villagomez, L. Liu, and Y. Cai for
   technical support and help. This work was supported by NIH (NS048271,
   HD069184), the Brain and Behavior Research Foundation (NARSAD), and the
   Maryland Stem Cell Research Fund (MSCRF) (to G.-l. M.), the Simons
   Foundation Autism Research Initiative (SFARI), NIH (NS047344, MH087874),
   and the International Mental Health Research Organization (IMHRO) to H.
   S., the Lieber Institute for Brain Development to D.R.W., J.E.K., and
   T.M.H., NARSAD and MSCRF to K.M.C., by fellowships from HFSP to K-j.Y.
   and MSCRF to G.M., N.-S.K., and Z.W., and from NIH (F31MH102978) to
   H.N.N.
CR Arnold SE, 1999, DEV PSYCHOPATHOL, V11, P439, DOI 10.1017/S095457949900214X
   Bellin M, 2012, NAT REV MOL CELL BIO, V13, P713, DOI 10.1038/nrm3448
   Bogdan S, 2004, DEVELOPMENT, V131, P3981, DOI 10.1242/dev.01274
   Bozdagi O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042422
   Buchman JJ, 2007, NAT REV NEUROSCI, V8, P89, DOI 10.1038/nrn2058
   Chiang CH, 2011, MOL PSYCHIATR, V16, P358, DOI 10.1038/mp.2011.13
   Christian K. C., 2012, FRONT BIOL, V7, P179
   Colantuoni C, 2011, NATURE, V478, P519, DOI 10.1038/nature10524
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
   De Wolf V, 2013, AM J MED GENET A, V161, P2846, DOI 10.1002/ajmg.a.36209
   Dubielecka PM, 2011, P NATL ACAD SCI USA, V108, P7022, DOI 10.1073/pnas.1016811108
   Englund C, 2005, J NEUROSCI, V25, P247, DOI 10.1523/JNEUROSCI.2899-04.2005
   Galy A, 2011, DEV BIOL, V359, P37, DOI 10.1016/j.ydbio.2011.08.009
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
   Itoh Y, 2013, NAT NEUROSCI, V16, P416, DOI 10.1038/nn.3336
   Jahn JA, 2014, EPILEPSY RES, V108, P109, DOI 10.1016/j.eplepsyres.2013.10.001
   Juopperi TA, 2012, MOL BRAIN, V5, DOI 10.1186/1756-6606-5-17
   Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
   Kobayashi K, 1998, J BIOL CHEM, V273, P291, DOI 10.1074/jbc.273.1.291
   Kriegstein A, 2009, ANNU REV NEUROSCI, V32, P149, DOI 10.1146/annurev.neuro.051508.135600
   Kunda P, 2003, CURR BIOL, V13, P1867, DOI 10.1016/j.cub.2003.10.005
   Leone DP, 2008, CURR OPIN NEUROBIOL, V18, P28, DOI 10.1016/j.conb.2008.05.006
   Li WL, 2011, P NATL ACAD SCI USA, V108, P8299, DOI 10.1073/pnas.1014041108
   Loulier K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000176
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Mattai AA, 2011, J AM ACAD CHILD PSY, V50, P697, DOI 10.1016/j.jaac.2011.03.016
   Mullen SA, 2013, NEUROLOGY, V81, P1507, DOI 10.1212/WNL.0b013e3182a95829
   Napoli I, 2008, CELL, V134, P1042, DOI 10.1016/j.cell.2008.07.031
   Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
   Rasin MR, 2007, NAT NEUROSCI, V10, P819, DOI 10.1038/nn1924
   Ross ME, 2001, ANNU REV NEUROSCI, V24, P1041, DOI 10.1146/annurev.neuro.24.1.1041
   Rousso DL, 2012, NEURON, V74, P314, DOI 10.1016/j.neuron.2012.02.024
   Saito T, 2006, NAT PROTOC, V1, P1552, DOI 10.1038/nprot.2006.276
   Schenck A, 2001, P NATL ACAD SCI USA, V98, P8844, DOI 10.1073/pnas.151231598
   Schenck A, 2003, NEURON, V38, P887, DOI 10.1016/S0896-6273(03)00354-4
   Shi YC, 2012, NAT NEUROSCI, V15, P477, DOI 10.1038/nn.3041
   Stefansson H, 2014, NATURE, V505, P361, DOI 10.1038/nature12818
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Steffen A, 2004, EMBO J, V23, P749, DOI 10.1038/sj.emboj.7600084
   Stoner R, 2014, NEW ENGL J MED, V370, P1209, DOI 10.1056/NEJMoa1307491
   Tam GWC, 2010, BIOCHEM SOC T, V38, P445, DOI 10.1042/BST0380445
   Thomson PA, 2013, FRONT BIOL, V8, P1, DOI DOI 10.1007/S11515-012-1254-7
   van der Zwaag B, 2010, AM J MED GENET B, V153B, P960, DOI 10.1002/ajmg.b.31055
   Vauti F, 2007, FEBS LETT, V581, P5691, DOI 10.1016/j.febslet.2007.11.031
   Wegiel J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035414
   WEINBERGER DR, 1987, ARCH GEN PSYCHIAT, V44, P660
   Yamazaki D, 2003, NATURE, V424, P452, DOI 10.1038/nature01770
   Yan C, 2003, EMBO J, V22, P3602, DOI 10.1093/emboj/cdg350
   Zhang FY, 2011, BIOL PSYCHIAT, V69, P914, DOI 10.1016/j.biopsych.2011.01.003
   Zhao L, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003450
   Zhao Q, 2013, SCHIZOPHRENIA BULL, V39, P712, DOI 10.1093/schbul/sbr197
NR 53
TC 6
Z9 6
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1934-5909
EI 1875-9777
J9 CELL STEM CELL
JI Cell Stem Cell
PD JUL 3
PY 2014
VL 15
IS 1
BP 79
EP 91
DI 10.1016/j.stem.2014.05.003
PG 13
WC Cell & Tissue Engineering; Cell Biology
SC Cell Biology
GA AN8TX
UT WOS:000340878600013
PM 24996170
ER

PT J
AU Maskey, M
   Lowry, J
   Rodgers, J
   McConachie, H
   Parr, JR
AF Maskey, Morag
   Lowry, Jessica
   Rodgers, Jacqui
   McConachie, Helen
   Parr, Jeremy R.
TI Reducing Specific Phobia/Fear in Young People with Autism Spectrum
   Disorders (ASDs) through a Virtual Reality Environment Intervention
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; COMORBID PSYCHIATRIC-DISORDERS; ANXIETY
   DISORDERS; CONTROLLED-TRIAL; CHILDREN; ADOLESCENTS; SYMPTOMS; YOUTH;
   POPULATION; RESPONSES
AB Anxiety is common in children with autism spectrum disorders (ASD), with specific fears and phobias one of the most frequent subtypes. Specific fears and phobias can have a serious impact on young people with ASD and their families. In this study we developed and evaluated a unique treatment combining cognitive behaviour therapy (CBT) with graduated exposure in a virtual reality environment (VRE). Nine verbally fluent boys with an ASD diagnosis and no reported learning disability, aged 7 to 13 years old, were recruited. Each had anxiety around a specific situation (e. g. crowded buses) or stimulus (e. g. pigeons). An individualised scene was recreated in our 'wrap-around' VRE. In the VRE participants were coached by a psychologist in cognitive and behavioural techniques (e.g. relaxation and breathing exercises) while the exposure to the phobia/fear stimulus was gradually increased as the child felt ready. Each child received four 20-30 minute sessions. After participating in the study, eight of the nine children were able to tackle their phobia situation. Four of the participants completely overcame their phobia. Treatment effects were maintained at 12 months. These results provide evidence that CBT with VRE can be a highly effective treatment for specific phobia/fear for some young people with ASD.
C1 [Maskey, Morag; Rodgers, Jacqui; Parr, Jeremy R.] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   [Lowry, Jessica; McConachie, Helen] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
RP Maskey, M (reprint author), Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
EM morag.maskey@ncl.ac.uk; Jeremy.parr@ncl.ac.uk
FU Newcastle University
FX Dr Morag Maskey has a Daphne Jackson Fellowship sponsored by Newcastle
   University (http://www.daphnejackson.org/). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Agostinis A., 2008, LEEDS RELIABLE CHANG
   Arnold LE, 2003, J AM ACAD CHILD PSY, V42, P1443, DOI 10.1097/01.chi.0000091946.28938.54
   Ashburner J, 2010, RES AUTISM SPECT DIS, V4, P18, DOI 10.1016/j.rasd.2009.07.002
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Drahota A, 2011, J AUTISM DEV DISORD, V41, P257, DOI 10.1007/s10803-010-1037-4
   Eaves LC, 2006, AUTISM, V10, P229, DOI 10.1177/1362361306063288
   FABRI M, 2007, HCI 07 P 12 INT C HU, V4552, P275, DOI 10.1007/978-3-540-73110-8_29
   Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7
   Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
   Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724
   IALONGO N, 1995, J CHILD PSYCHOL PSYC, V36, P427, DOI 10.1111/j.1469-7610.1995.tb01300.x
   JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
   Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9
   Josman N, 2008, INT J DISABIL HUM DE, V7, P49
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lind SE, 2014, NEUROPSYCHOLOGY, V28, P55, DOI 10.1037/neu0000005
   Loveland KA, 2005, TYPICAL IMPAIRED EMO, P365
   Low J, 2009, BRIT J DEV PSYCHOL, V27, P425, DOI 10.1348/026151008X334728
   Maskey M, 2013, J AUTISM DEV DISORD, V43, P851, DOI 10.1007/s10803-012-1622-9
   Mattila ML, 2010, J AUTISM DEV DISORD, V40, P1080, DOI 10.1007/s10803-010-0958-2
   Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P151, DOI 10.1016/j.rasd.2012.08.002
   McConachie H, 2009, ARCH DIS CHILD, V94, P38, DOI 10.1136/adc.2007.126326
   McConachie H, 2013, AUTISM
   McPheeters ML, 2011, J AUTISM DEV DISORD, V41, P646, DOI 10.1007/s10803-010-1085-9
   Mitchell P, 2007, J AUTISM DEV DISORD, V37, P589, DOI 10.1007/s10803-006-0189-8
   Moore M, 2000, J AUTISM DEV DISORD, V30, P359, DOI 10.1023/A:1005535602064
   Moree BN, 2010, RES AUTISM SPECT DIS, V4, P346, DOI 10.1016/j.rasd.2009.10.015
   National Institute for Health and Clinical Excellence (NICE) Autism, 2011, REC REF DIAGN CHILDR
   Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6
   Ollendick TH, 2006, HDB INTERVENTIONS WO, P3
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   Ozsivadjian Ann, 2011, Clin Child Psychol Psychiatry, V16, P203, DOI 10.1177/1359104511404749
   Pine DS, 1998, ARCH GEN PSYCHIAT, V55, P56, DOI 10.1001/archpsyc.55.1.56
   Puleo CM, 2011, J AUTISM DEV DISORD, V41, P275, DOI 10.1007/s10803-010-1047-2
   Rieffe C, 2007, J AUTISM DEV DISORD, V37, P455, DOI 10.1007/s10803-006-0171-5
   Rothbaum BO, 1999, BEHAV MODIF, V23, P507, DOI 10.1177/0145445599234001
   Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975
   Silverman W. K., 1996, ANXIETY DISORDERS IN
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Slater M, 2006, CYBERPSYCHOL BEHAV, V9, P627, DOI 10.1089/cpb.2006.9.627
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
   Strickland DC, 2007, TOP LANG DISORD, V27, P226
   van Steensel FJA, 2013, J AUTISM DEV DISORD, P1
   Wallace S, 2010, AUTISM, V14, P199, DOI 10.1177/1362361310363283
   Witwer AN, 2010, J DEV PHYS DISABIL, V22, P367, DOI 10.1007/s10882-010-9194-0
   Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
NR 49
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 2
PY 2014
VL 9
IS 7
AR e100374
DI 10.1371/journal.pone.0100374
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO5BA
UT WOS:000341354100029
PM 24987957
ER

PT J
AU Ross, KA
AF Ross, Kenneth Andrew
TI Coherent Somatic Mutation in Autoimmune Disease
SO PLOS ONE
LA English
DT Article
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; AUTISM SPECTRUM DISORDERS; JUVENILE
   IDIOPATHIC ARTHRITIS; INFLAMMATORY-BOWEL-DISEASE;
   CORONARY-ARTERY-DISEASE; PRIMARY BILIARY-CIRRHOSIS;
   NATURAL-KILLER-CELLS; MYELIN-ASSOCIATED GLYCOPROTEIN; ANTI-PITUITARY
   ANTIBODIES; OF-FUNCTION MUTATIONS
AB Background: Many aspects of autoimmune disease are not well understood, including the specificities of autoimmune targets, and patterns of co-morbidity and cross-heritability across diseases. Prior work has provided evidence that somatic mutation caused by gene conversion and deletion at segmentally duplicated loci is relevant to several diseases. Simple tandem repeat (STR) sequence is highly mutable, both somatically and in the germ-line, and somatic STR mutations are observed under inflammation.
   Results: Protein-coding genes spanning STRs having markers of mutability, including germ-line variability, high total length, repeat count and/or repeat similarity, are evaluated in the context of autoimmunity. For the initiation of autoimmune disease, antigens whose autoantibodies are the first observed in a disease, termed primary autoantigens, are informative. Three primary autoantigens, thyroid peroxidase (TPO), phogrin (PTPRN2) and filaggrin (FLG), include STRs that are among the eleven longest STRs spanned by protein-coding genes. This association of primary autoantigens with long STR sequence is highly significant (p<3.0 x 10(-7)). Long STRs occur within twenty genes that are associated with sixteen common autoimmune diseases and atherosclerosis. The repeat within the TTC34 gene is an outlier in terms of length and a link with systemic lupus erythematosus is proposed.
   Conclusions: The results support the hypothesis that many autoimmune diseases are triggered by immune responses to proteins whose DNA sequence mutates somatically in a coherent, consistent fashion. Other autoimmune diseases may be caused by coherent somatic mutations in immune cells. The coherent somatic mutation hypothesis has the potential to be a comprehensive explanation for the initiation of many autoimmune diseases.
C1 Columbia Univ, Dept Comp Sci, New York, NY 10027 USA.
RP Ross, KA (reprint author), Columbia Univ, Dept Comp Sci, New York, NY 10027 USA.
EM kar@cs.columbia.edu
CR Abdulahad DA, 2011, ARTHRITIS RES THER, V13, DOI 10.1186/ar3332
   Abreu-Velez Ana Maria, 2012, N Am J Med Sci, V4, P1, DOI 10.4103/1947-2714.92892
   Abyzov A, 2012, NATURE, V492, P438, DOI 10.1038/nature11629
   Adams JN, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-31
   Agmon-Levin N, 2013, CLIN REV ALLERG IMMU, V44, P1, DOI 10.1007/s12016-012-8335-x
   Aho K, 2000, J RHEUMATOL, V27, P2743
   AICHELE P, 1994, P NATL ACAD SCI USA, V91, P444, DOI 10.1073/pnas.91.2.444
   Alaedini A, 2008, AUTOIMMUNITY, V41, P19, DOI 10.1080/08916930701619219
   Albert LJ, 1999, NEW ENGL J MED, V341, P2068, DOI 10.1056/NEJM199912303412707
   Alkan C, 2011, NAT METHODS, V8, P61, DOI [10.1038/nmeth.1527, 10.1038/NMETH.1527]
   Allen KL, 2012, BLOOD, V119, P884, DOI 10.1182/blood-2011-03-344671
   Andersson M, 2002, EUR J NEUROL, V9, P243, DOI 10.1046/j.1468-1331.2002.00391.x
   Ando K, 2010, FEBS J, V277, P2051, DOI 10.1111/j.1742-4658.2010.07620.x
   Andrews SF, 2010, BLOOD, V115, P4976, DOI 10.1182/blood-2010-03-276352
   Annibale Bruno, 2011, Curr Gastroenterol Rep, V13, P518, DOI 10.1007/s11894-011-0225-5
   [Anonymous], 2013, ENCODE PROJECT STAT
   Antonelli A, 2007, EUR J ENDOCRINOL, V156, P431, DOI 10.1530/EJE-06-0591
   Arbuckle MR, 2003, NEW ENGL J MED, V349, P1526, DOI 10.1056/NEJMoa021933
   Arechiga AF, 2009, J IMMUNOL, V182, P3343, DOI 10.4049/jimmunol.0713370
   Ariyo AA, 2003, NEW ENGL J MED, V349, P2108, DOI 10.1056/NEJMoa001066
   ARMOUR JAL, 1989, GENOMICS, V4, P328, DOI 10.1016/0888-7543(89)90338-8
   Arur S, 2003, DEV CELL, V4, P587, DOI 10.1016/S1534-5807(03)00090-X
   Arvanitis DN, 2002, J NEUROSCI RES, V70, P8, DOI 10.1002/jnr.10383
   Asakawa J, 1999, P NATL ACAD SCI USA, V96, P10314, DOI 10.1073/pnas.96.18.10314
   Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445
   AYER LM, 1994, J RHEUMATOL, V21, P2071
   Bachmann MP, 2006, J IMMUNOL, V177, P1698
   Backes C, 2011, BMC GENOMICS, V12, DOI 10.1186/1471-2164-12-340
   Bailey JA, 2001, GENOME RES, V11, P1005, DOI 10.1101/gr.GR-1871R
   Baillie JK, 2011, NATURE, V479, P534, DOI 10.1038/nature10531
   Ball MP, 2009, NAT BIOTECHNOL, V27, P361, DOI 10.1038/nbt.1533
   Bang H, 2007, ARTHRITIS RHEUM, V56, P2503, DOI 10.1002/art.22817
   Banka S, 2011, AUTOIMMUN REV, V10, P455, DOI 10.1016/j.autrev.2011.01.009
   Barker RN, 2007, IMMUNOL LETT, V108, P20, DOI 10.1016/j.imlet.2006.10.005
   Barrera MJ, 2012, J AUTOIMMUN, V39, P83, DOI 10.1016/j.jaut.2012.01.011
   Baxter AG, 2002, AUTOIMMUNITY, V35, P1, DOI 10.1080/08916930290005864
   Becker J, 2013, NAT STRUCT MOL BIOL, V20, P525, DOI 10.1038/nsmb.2526
   Bei R, 2009, CANCER LETT, V281, P8, DOI 10.1016/j.canlet.2008.11.009
   Bellastella G, 2013, DIABETES CARE, V36, pE116, DOI 10.2337/dc13-0637
   Benoist C, 2001, NAT IMMUNOL, V2, P797, DOI 10.1038/ni0901-797
   Benson G, 1999, NUCLEIC ACIDS RES, V27, P573, DOI 10.1093/nar/27.2.573
   Berg CP, 2010, BMC GASTROENTEROL, V10, DOI 10.1186/1471-230X-10-120
   Bertolaccini ML, 2013, THROMB HAEMOSTASIS, V109, P207, DOI 10.1160/TH12-07-0527
   Betz RC, 2008, BRIT J DERMATOL, V158, P389, DOI 10.1111/j.1365-2133.2007.08312.x
   Biancone L, 1998, CLIN EXP IMMUNOL, V113, P198
   Blander JM, 2012, IMMUNOL RES, V54, P50, DOI 10.1007/s12026-012-8311-9
   BOEHM J, 1994, EUR J CLIN INVEST, V24, P248, DOI 10.1111/j.1365-2362.1994.tb01082.x
   Boelaert K, 2010, AM J MED, V123, P1
   BOIRE G, 1990, J CLIN INVEST, V85, P1182, DOI 10.1172/JCI114551
   Bois PRJ, 2003, GENOMICS, V81, P349, DOI 10.1016/S0888-7543(03)00021-1
   Boksa P, 2008, J PSYCHIATR NEUROSCI, V33, P183
   Bondanza A, 2001, THROMB HAEMOSTASIS, V86, P1257
   BONFA E, 1987, NEW ENGL J MED, V317, P265, DOI 10.1056/NEJM198707303170503
   Bonne S, 2003, J CELL BIOL, V161, P403, DOI 10.1083/jcb.200303036
   Boulatnikov I, 2004, J BIOL CHEM, V279, P40918, DOI 10.1074/jbc.M406213200
   Brideau CM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013784
   Brimberg L, 2013, MOL PSYCHIAT
   Brouwers N, 2012, MOL PSYCHIATR, V17, P223, DOI 10.1038/mp.2011.24
   Brown AS, 2012, DEV NEUROBIOL, V72, P1272, DOI 10.1002/dneu.22024
   Brown J. Mark, 2009, Immunology Endocrine & Metabolic Agents in Medicinal Chemistry, V9, P18
   Bruder CEG, 2008, AM J HUM GENET, V82, P763, DOI 10.1016/j.ajhg.2007.12.011
   Bruderer R, 2011, EMBO REP, V12, P142, DOI 10.1038/embor.2010.206
   Bryant AE, 2006, J INFECT DIS, V193, P1685, DOI 10.1086/504261
   Buard J, 2000, GENOMICS, V65, P95, DOI 10.1006/geno.2000.6161
   Buisine MP, 1999, INFLAMM BOWEL DIS, V5, P24
   Burn GL, 2011, FEBS LETT, V585, P3689, DOI 10.1016/j.febslet.2011.04.032
   Butterworth AS, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002260
   Caccavo D, 2005, CLIN RHEUMATOL, V24, P381, DOI 10.1007/s10067-004-1040-2
   Cameron AL, 2003, BRIT J DERMATOL, V149, P160, DOI 10.1046/j.1365-2133.2003.05319.x
   Cardenas-Roldan J, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-73
   CARPENTER WT, 1994, NEW ENGL J MED, V330, P681, DOI 10.1056/NEJM199403103301006
   Casciola-Rosen L, 1999, J EXP MED, V190, P815, DOI 10.1084/jem.190.6.815
   Casciola-Rosen L, 2012, CURR OPIN RHEUMATOL, V24, P602, DOI 10.1097/BOR.0b013e328358bd85
   Castro I, 2013, AUTOIMMUN REV, V12, P567, DOI 10.1016/j.autrev.2012.10.018
   Catts VS, 2012, WORLD J BIOL PSYCHIA, V13, P114, DOI 10.3109/15622975.2011.565073
   Cavalcante P, 2012, CURR OPIN NEUROL, V25, P621, DOI 10.1097/WCO.0b013e328357a829
   Cavazzana I, 2011, J RHEUMATOL, V38, P2180, DOI 10.3899/jrheum.110167
   Ceribelli A, 2011, ARTHRITIS RES THER, V13, DOI 10.1186/ar3422
   Chamley LW, 1999, CLIN EXP IMMUNOL, V115, P571
   Chandley MJ, 2009, SCHIZOPHR RES, V109, P98, DOI 10.1016/j.schres.2009.01.023
   Chu SY, 2011, J AM ACAD DERMATOL, V65, P949, DOI 10.1016/j.jaad.2010.08.032
   Chaturvedi P, 2008, FASEB J, V22, P966, DOI 10.1096/fj.07-9673rev
   Chen JM, 2007, NAT REV GENET, V8, P762, DOI 10.1038/nrg2193
   Chen L, 2008, FEBS LETT, V582, P2843, DOI 10.1016/j.febslet.2008.07.014
   Chen L, 2008, INVEST OPHTH VIS SCI, V49, P4476, DOI 10.1167/iovs.08-1971
   Chen SJ, 2012, BRIT J PSYCHIAT, V200, P374, DOI 10.1192/bjp.bp.111.092098
   Cheng ST, 1996, J IMMUNOL, V156, P4484
   Chinoy H, 2008, ARTHRITIS RHEUM, V58, P3247, DOI 10.1002/art.23900
   Waterston RH, 2002, NATURE, V420, P520, DOI 10.1038/nature01262
   Cho JH, 2011, NEW ENGL J MED, V365, P1612, DOI 10.1056/NEJMra1100030
   Choi KH, 2005, EXP MOL MED, V37, P546
   Chowdhury D, 2008, MOL CELL, V31, P33, DOI 10.1016/j.molcel.2008.05.016
   Clemente MG, 2000, GUT, V47, P520, DOI 10.1136/gut.47.4.520
   Cohen PTW, 2005, FEBS LETT, V579, P3278, DOI 10.1016/j.febslet.2005.04.070
   Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
   Cooper GS, 2009, J AUTOIMMUN, V33, P197, DOI 10.1016/j.jaut.2009.09.008
   Coppolino MG, 1999, BIOCHEM J, V340, P41, DOI 10.1042/0264-6021:3400041
   Cossins J, 2012, ANN NY ACAD SCI, V1275, P123, DOI 10.1111/j.1749-6632.2012.06833.x
   Crespi BJ, 2011, GENES BRAIN BEHAV, V10, P689, DOI 10.1111/j.1601-183X.2011.00710.x
   Criswell LA, 2005, AM J HUM GENET, V76, P561, DOI 10.1086/429096
   Cunningham MW, 2000, CLIN MICROBIOL REV, V13, P470, DOI 10.1128/CMR.13.3.470-511.2000
   Curran LK, 2007, PEDIATRICS, V120, pE1386, DOI 10.1542/peds.2007-0360
   Dalmau J, 2007, ANN NEUROL, V61, P25, DOI 10.1002/ana.21050
   Dangas G, 1999, AM J CARDIOL, V83, P583, DOI 10.1016/S0002-9149(98)00917-5
   Day INM, 2004, J CLIN ENDOCR METAB, V89, P5569, DOI 10.1210/jc.2004-0152
   Deeg Cornelia A, 2007, Clin Dev Immunol, V2007, P39245, DOI 10.1155/2007/39245
   De Lisle RC, 2002, J CELL SCI, V115, P2941
   Delvecchio M, 2010, AM J GASTROENTEROL, V105, P691, DOI 10.1038/ajg.2009.642
   Devlin SM, 2007, GASTROENTEROLOGY, V132, P576, DOI 10.1053/j.gastro.2006.11.013
   Diaz-Gallo L, 2011, ANN RHEUM DIS, V70, P454, DOI 10.1136/ard.2010.130138
   Dittwald P, 2013, GENOME RES, V23, P1395, DOI 10.1101/gr.152454.112
   Di Zenzo G, 2012, J CLIN INVEST, V122, P3781, DOI 10.1172/JCI64413
   Doster A, 2013, IMMUNOLOGY, V139, P166, DOI 10.1111/imm.12063
   Douville R, 2011, ANN NEUROL, V69, P141, DOI 10.1002/ana.22149
   Doyle HA, 2012, CURR OPIN IMMUNOL, V24, P112, DOI 10.1016/j.coi.2011.12.003
   Drouet J, 2005, J BIOL CHEM, V280, P7060, DOI 10.1074/jbc.M410746200
   Drummond JB, 2013, SCHIZOPHR RES, V147, P32, DOI 10.1016/j.schres.2013.03.010
   Duchan E, 2012, PEDIATR CLIN N AM, V59, P27, DOI 10.1016/j.pcl.2011.10.003
   Dumas L, 2009, Cold Spring Harb Symp Quant Biol, V74, P375, DOI 10.1101/sqb.2009.74.025
   Dumas LJ, 2012, AM J HUM GENET, V91, P444, DOI 10.1016/j.ajhg.2012.07.016
   Eaton WW, 2006, AM J PSYCHIAT, V163, P521, DOI 10.1176/appi.ajp.163.3.521
   Eaton WW, 2010, BIPOLAR DISORD, V12, P638, DOI 10.1111/j.1399-5618.2010.00853.x
   Eggleton P, 2000, CLIN EXP IMMUNOL, V120, P384, DOI 10.1046/j.1365-2249.2000.01214.x
   Ellegren H, 2004, NAT REV GENET, V5, P435, DOI 10.1038/nrg1348
   Endo T, 2009, DIABETES, V58, P732, DOI 10.2337/db08-0493
   Engelhorn ME, 2006, NAT MED, V12, P198, DOI 10.1038/nm1363
   Enstrom AM, 2009, BRAIN BEHAV IMMUN, V23, P124, DOI 10.1016/j.bbi.2008.08.001
   Erdei A, 2009, MOL IMMUNOL, V46, P2767, DOI 10.1016/j.molimm.2009.05.181
   Ewing RM, 2007, MOL SYST BIOL, V3, DOI 10.1038/msb4100134
   Fae KC, 2006, J IMMUNOL, V176, P5662
   Farhat SCL, 2011, AUTOIMMUN REV, V11, P14, DOI 10.1016/j.autrev.2011.06.008
   Farid NR, 2000, EUR J ENDOCRINOL, V143, P25, DOI 10.1530/eje.0.1430025
   Fasano A, 2000, LANCET, V355, P1518, DOI 10.1016/S0140-6736(00)02169-3
   Fasano A, 2012, ANN NY ACAD SCI, V1258, P25, DOI 10.1111/j.1749-6632.2012.06538.x
   Fasano A, 2005, NAT CLIN PRACT GASTR, V2, P416, DOI 10.1038/ncpgasthep0259
   Fichna M, 2010, ENDOCRINE, V37, P349, DOI 10.1007/s12020-010-9312-x
   Fiorillo E, 2010, J BIOL CHEM, V285, P26506, DOI 10.1074/jbc.M110.111104
   Firestein GS, 1997, P NATL ACAD SCI USA, V94, P10895, DOI 10.1073/pnas.94.20.10895
   Fitzgerald ML, 2010, ATHEROSCLEROSIS, V211, P361, DOI 10.1016/j.atherosclerosis.2010.01.011
   Flores M, 2007, P NATL ACAD SCI USA, V104, P6099, DOI 10.1073/pnas.0701631104
   Forsberg LA, 2013, J MED GENET, V50, P1, DOI 10.1136/jmedgenet-2012-101322
   Fowler JC, 2003, HUM GENET, V113, P473, DOI 10.1007/s00439-003-1011-8
   Franceschini A, 2013, NUCLEIC ACIDS RES, V41, pD808, DOI 10.1093/nar/gks1094
   Fuchs F, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.25
   Fuhrer D, 1997, J CLIN ENDOCR METAB, V82, P3885, DOI 10.1210/jc.82.11.3885
   Galande S, 1999, J BIOL CHEM, V274, P20521, DOI 10.1074/jbc.274.29.20521
   Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
   Gauba V, 2011, P NATL ACAD SCI USA, V108, P12821, DOI 10.1073/pnas.1110042108
   Gershwin ME, 2011, CLIN REV ALLERG IMMU, V41, P123, DOI 10.1007/s12016-011-8283-x
   Ghillani P, 2011, AUTOIMMUN REV, V10, P509, DOI 10.1016/j.autrev.2011.03.004
   GHISELLI G, 1981, SCIENCE, V214, P1239, DOI 10.1126/science.6795720
   Gilat Y, 2011, ISR J PSYCHIATR REL, V48, P275
   Gnerre S, 2011, P NATL ACAD SCI USA, V108, P1513, DOI 10.1073/pnas.1017351108
   Godfrey JD, 2010, GASTROENTEROLOGY, V139, P763, DOI 10.1053/j.gastro.2010.05.041
   Golebiowski F, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000282
   Gomez LM, 2005, GENES IMMUN, V6, P628, DOI 10.1038/sj.gene.6364261
   Gomez-Puerta JA, 2008, AUTOIMMUN REV, V7, P606, DOI 10.1016/j.autrev.2008.06.005
   Gough SCL, 2005, IMMUNOL REV, V204, P102, DOI 10.1111/j.0105-2896.2005.00249.x
   Graf GA, 2003, J BIOL CHEM, V278, P48275, DOI 10.1074/jbc.M310223200
   Greco D, 2011, PRIM CARE DIABETES, V5, P241, DOI 10.1016/j.pcd.2011.06.001
   Greenow K, 2005, J MOL MED-JMM, V83, P329, DOI 10.1007/s00109-004-0631-3
   Gregersen PK, 2012, ANN NEUROL, V72, P927, DOI 10.1002/ana.23691
   Greve B, 2009, HUM IMMUNOL, V70, P540, DOI 10.1016/j.humimm.2009.04.027
   Guerranti R, 2010, INT J IMMUNOPATH PH, V23, P901
   Gugliesi F, 2010, J AUTOIMMUN, V35, P114, DOI 10.1016/j.jaut.2010.04.001
   Guo X, 2013, AM J RESP CELL MOL B
   Hagforsen E, 2007, J INVEST DERMATOL, V127, P2276, DOI 10.1038/sj.jid.5700848
   Halvorsen EH, 2008, ANN RHEUM DIS, V67, P414, DOI 10.1136/ard.2007.080267
   Hamaguchi Y, 2010, J DERMATOL, V37, P42, DOI 10.1111/j.1346-8138.2009.00762.x
   Han BY, 2005, NAT MED, V11, P645, DOI 10.1038/nm1250
   Hannan AJ, 2010, DISCOV MED, V53, P314
   Hansen B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026438
   Hansson GK, 2011, NAT IMMUNOL, V12, P204, DOI 10.1038/ni.2001
   Hansson G K, 1999, Curr Atheroscler Rep, V1, P150, DOI 10.1007/s11883-999-0011-0
   Harrow J, 2012, GENOME RES, V22, P1760, DOI 10.1101/gr.135350.111
   Hedstrand H, 2000, BIOCHEM BIOPH RES CO, V267, P456, DOI 10.1006/bbrc.1999.1945
   Hedstrom AK, 2011, BRAIN, V134, P653, DOI 10.1093/brain/awq371
   Heinlen LD, 2010, J MOL MED, V88, P719, DOI 10.1007/s00109-010-0618-1
   Hemminki Kari, 2010, J Autoimmun, V34, pJ307, DOI 10.1016/j.jaut.2009.11.019
   Hemminki K, 2009, ARTHRITIS RHEUM, V60, P2845, DOI 10.1002/art.24749
   Hinks A, 2013, NAT GENET, V45, P664, DOI 10.1038/ng.2614
   Hirai H, 2008, CLIN IMMUNOL, V127, P366, DOI 10.1016/j.clim.2008.01.018
   Hirschfield GM, 2013, GASTROENTEROLOGY, V144, P1357, DOI 10.1053/j.gastro.2013.03.053
   Holmes R, 2006, MOL CELL BIOL, V26, P9564, DOI 10.1128/MCB.00058-06
   Holmqvist ME, 2009, ARTHRITIS RHEUM, V60, P2861, DOI 10.1002/art.24855
   Hoppu S, 2006, CLIN EXP IMMUNOL, V144, P59, DOI 10.1111/j.1365-2249.2006.03033.x
   Hu WL, 2011, RHEUMATOL INT, V31, P819, DOI 10.1007/s00296-010-1576-1
   Huffmeier U, 2008, ANN RHEUM DIS, V67, P131, DOI 10.1136/ard.2007.073239
   Hutfless S, 2011, J CLIN ENDOCR METAB, V96, pE1466, DOI 10.1210/jc.2011-0228
   Iaccarino L, 2011, AUTOIMMUN REV, V10, P553, DOI 10.1016/j.autrev.2011.04.007
   Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
   Icenogle LM, 2012, J BIOL CHEM, V287, P21481, DOI 10.1074/jbc.M112.370791
   Ichiki T, 2010, VASC PHARMACOL, V52, P151, DOI 10.1016/j.vph.2009.09.004
   Illien F, 2012, BBA-BIOMEMBRANES, V1818, P2892, DOI 10.1016/j.bbamem.2012.07.012
   Imura-Kumada S, 2012, MOD RHEUMATOL, V22, P892, DOI 10.1007/s10165-012-0607-z
   Iourov IY, 2013, CYTOGENET GENOME RES, V139, P181, DOI 10.1159/000347053
   Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
   Isshi K, 1996, ARTHRITIS RHEUM, V39, P1483, DOI 10.1002/art.1780390907
   Ito Y, 1998, NEUROCHEM RES, V23, P25, DOI 10.1023/A:1022441101801
   Ittah M, 2005, GENES IMMUN, V6, P457, DOI 10.1038/sj.gene.6364299
   Izquierdo M, 1999, EMBO J, V18, P156, DOI 10.1093/emboj/18.1.156
   JACOB M, 1992, BIOCHEM CELL BIOL, V70, P1105
   Janeway C, 2001, IMMUNOBIOLOGY IMMUNE
   Janka C, 2005, HEPATOLOGY, V41, P609, DOI 10.1002/hep.20619
   Jin Y, 2010, NEW ENGL J MED, V362, P1686, DOI 10.1056/NEJMoa0908547
   Jonsson L, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-10
   Jostins L, 2012, NATURE, V491, P119, DOI 10.1038/nature11582
   Kakourou T, 2005, J AM ACAD DERMATOL, V53, P220, DOI 10.1016/j.jaad.2005.03.032
   Kalantari-Dehaghi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057587
   Karlsen TH, 2007, J HEPATOL, V46, P899, DOI 10.1016/j.jhep.2007.01.032
   Karlsson H, 2001, P NATL ACAD SCI USA, V98, P4634, DOI 10.1073/pnas.061021998
   Kastner DL, 2010, CELL, V140, P784, DOI 10.1016/j.cell.2010.03.002
   Kastrukoff LF, 2003, J NEUROIMMUNOL, V145, P103, DOI 10.1016/j.jneuroim.2003.10.001
   Kastrukoff LF, 1999, NEUROLOGY, V52, P351
   Kato AS, 2010, NEURON, V68, P1082, DOI 10.1016/j.neuron.2010.11.026
   Kaur G, 2013, BRAIN, V136, P2657, DOI 10.1093/brain/aws159
   Keil A, 2010, EPIDEMIOLOGY, V21, P805, DOI 10.1097/EDE.0b013e3181f26e3f
   Kemp EH, 2011, EXP DERMATOL, V20, P35, DOI 10.1111/j.1600-0625.2010.01181.x
   Kemp EH, 2011, BRIT J DERMATOL, V165, P1236, DOI 10.1111/j.1365-2133.2011.10597.x
   Kemp EH, 2006, HUM IMMUNOL, V67, P535, DOI 10.1016/j.humimm.2006.04.006
   Kenny EE, 2009, P NATL ACAD SCI USA, V106, P13886, DOI 10.1073/pnas.0907336106
   Kent WJ, 2003, P NATL ACAD SCI USA, V100, P11484, DOI 10.1073/pnas.1932072100
   Khodzhigorova A, 2012, ANN RHEUM DIS, V71, P1904, DOI 10.1136/annrheumdis-2012-201746
   Kim Young S, 2010, Curr Gastroenterol Rep, V12, P319, DOI 10.1007/s11894-010-0131-2
   Kirby A, 2013, NAT GENET, V45, P299, DOI 10.1038/ng.2543
   Kobayashi K, 2001, IMMUNOL LETT, V79, P229, DOI 10.1016/S0165-2478(01)00288-7
   Kobayashi T, 1997, DIABETES CARE, V20, P864, DOI 10.2337/diacare.20.5.864
   Komorowski L, 2013, J CROHNS COLITIS, V7, P780, DOI 10.1016/j.crohns.2012.10.011
   Komurasaki R, 2010, DRUG METAB PHARMACOK, V25, P84
   Kostadinov RL, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003553
   Kovacs L, 2008, CLIN IMMUNOL, V128, P269, DOI 10.1016/j.clim.2008.04.001
   Kubo M, 2002, J AM ACAD DERMATOL, V47, P148, DOI 10.1067/mjd.2002.121037
   Kubosaki A, 2004, DIABETES, V53, P1684, DOI 10.2337/diabetes.53.7.1684
   Kumar V, 2013, INFLAMM BOWEL DIS, V19, P1254, DOI 10.1097/MIB.0b013e318281f454
   Lam KWG, 2006, P NATL ACAD SCI USA, V103, P8921, DOI 10.1073/pnas.0602690103
   Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
   Langkamp M, 2009, CLIN CHEM LAB MED, V47, P1395, DOI 10.1515/CCLM.2009.313
   Langlois MR, 1996, CLIN CHEM, V42, P1589
   Laning JC, 2001, TRANSPLANTATION, V71, P1467, DOI 10.1097/00007890-200105270-00019
   Lartigue A, 2005, ARTHRITIS RES THER, V7, pR1394, DOI 10.1186/ar1838
   Lauc G, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003225
   Lee HH, 2013, CLIN CHIM ACTA, V418, P37, DOI 10.1016/j.cca.2012.12.030
   Lee KH, 1999, FEBS LETT, V442, P143, DOI 10.1016/S0014-5793(98)01643-3
   Lee SH, 2003, J IMMUNOL, V170, P2214
   Lee YH, 2012, INFLAMM RES, V61, P411, DOI 10.1007/s00011-012-0447-5
   Lee YH, 2012, MOL BIOL REP, V39, P3103, DOI 10.1007/s11033-011-1074-x
   Lefvert AK, 2008, J NEUROIMMUNOL, V197, P110, DOI 10.1016/j.jneuroim.2008.04.004
   Legendre M, 2007, GENOME RES, V17, P1787, DOI 10.1101/gr.6554007
   Leslie R. D. G., 1994, Acta Geneticae Medicae et Gemellologiae, V43, P71
   Leung MC, 2010, J PROTEOME RES, V9, P5153, DOI 10.1021/pr100422u
   Li QA, 2011, J INVEST DERMATOL, V131, P727, DOI 10.1038/jid.2010.341
   Li X, 2013, J AM ACAD DERMATOL
   Li XL, 2005, CELL, V122, P365, DOI 10.1016/j.cell.2005.06.008
   Liaskos C, 2013, CLIN DEV IMMUNOL, DOI 10.1155/2013/968041
   Lin YF, 2010, P NATL ACAD SCI USA, V107, P692, DOI 10.1073/pnas.0909740107
   Lipinska J, 2012, J RHEUMATOL, V39, P1078, DOI 10.3899/jrheum.110879
   Liu G, 2008, J IMMUNOL, V181, P4240
   Liu PF, 2012, CURR OPIN GENET DEV, V22, P211, DOI [10.1016/j.gde.2012.02.012, 10.1016/j.gde.20112.02.012]
   Lleo A, 2011, J GASTROENTEROL, V46, P29, DOI 10.1007/s00535-010-0303-8
   Lobachev KS, 2007, FRONT BIOSCI, V12, P4208, DOI 10.2741/2381
   Locht H, 2000, ANN RHEUM DIS, V59, P898, DOI 10.1136/ard.59.11.898
   Lorentzen AR, 2009, ANN NEUROL, V65, P658, DOI 10.1002/ana.21695
   Lu LR, 2008, P NATL ACAD SCI USA, V105, P19420, DOI 10.1073/pnas.0810383105
   Lunn MPT, 2002, BRAIN, V125, P904, DOI 10.1093/brain/awf072
   Luo XJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050375
   Lupski JR, 2007, NAT GENET, V39, pS43, DOI 10.1038/ng2084
   Lupski JR, 2013, SCIENCE, V341, P358, DOI 10.1126/science.1239503
   Lupski JR, 2011, CELL, V147, P32, DOI 10.1016/j.cell.2011.09.008
   Lupski JR, 2012, BIOL PSYCHIAT, V72, P617, DOI 10.1016/j.biopsych.2012.08.007
   Luu Y, 2010, INT J BIOCHEM CELL B, V42, P996, DOI 10.1016/j.biocel.2010.03.001
   Mahdi H, 2009, NAT GENET, V41, P1319, DOI 10.1038/ng.480
   Mahler M, 2011, CLIN CHIM ACTA, V412, P1937, DOI 10.1016/j.cca.2011.06.041
   Majone F, 2007, ANN NY ACAD SCI, V1108, P240, DOI 10.1196/annals.1422.026
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Mao ZF, 2011, INT J NEUROSCI, V121, P121, DOI 10.3109/00207454.2010.539307
   Mårdh S, 1990, J Intern Med Suppl, V732, P77
   MARDH S, 1989, ACTA PHYSIOL SCAND, V136, P581
   Margeirsdottir HD, 2008, DIABETOLOGIA, V51, P554, DOI 10.1007/s00125-007-0921-8
   Martin TM, 2009, MOL VIS, V15, P208
   Martins TB, 2008, INT IMMUNOL, V20, P445, DOI 10.1093/intimm/dxn004
   Mazur-Kolecka B, 2013, BRAIN DEV
   McClain MT, 2004, ARTHRITIS RHEUM, V50, P1226, DOI 10.1002/art.20120
   MCCORMICK DA, 1990, J CLIN PATHOL, V43, P143, DOI 10.1136/jcp.43.2.143
   McLaughlin KA, 2008, ADV IMMUNOL, V98, P121, DOI 10.1016/S0065-2776(08)00404-5
   Mehra S, 2013, AUTOIMMUN REV, V12, P340, DOI 10.1016/j.autrev.2012.05.011
   Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
   MELVOLD RW, 1971, MUTAT RES, V12, P171, DOI 10.1016/0027-5107(71)90138-2
   Menard L, 2011, J CLIN INVEST, V121, P3635, DOI 10.1172/JCI45790
   Menge T, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-161
   Meroni PL, 2004, AUTOIMMUN REV, V3, P510, DOI 10.1016/j.autrev.2004.07.007
   Meyer LR, 2013, NUCLEIC ACIDS RES, V41, pD64, DOI 10.1093/nar/gks1048
   MINOTA S, 1991, J IMMUNOL, V146, P2249
   Mischo HE, 2005, J BIOL CHEM, V280, P9586, DOI 10.1074/jbc.M411444200
   Moehle C, 2006, J MOL MED-JMM, V84, P1055, DOI 10.1007/s00109-006-0100-2
   Moon SJ, 2013, OCUL IMMUNOL INFLAMM, V21, P135, DOI 10.3109/09273948.2012.754905
   Morshed SA, 2012, IMMUNOL RES, V54, P191, DOI 10.1007/s12026-012-8312-8
   Mor-Vaknin N, 2011, ARTHRITIS RHEUM-US, V63, P556, DOI 10.1002/art.30138
   Mostafa GA, 2009, PEDIATR NEUROL, V40, P107, DOI 10.1016/j.pediatrneurol.2008.10.017
   Mostafalou S, 2013, TOXICOL APPL PHARM, V268, P157, DOI 10.1016/j.taap.2013.01.025
   Mourtada-Maarabouni M, 2009, LEUKEMIA RES, V33, P1539, DOI 10.1016/j.leukres.2009.05.013
   Mullighan CG, 2008, NATURE, V453, P110, DOI 10.1038/nature06866
   Myers EW, 2002, P NATL ACAD SCI USA, V99, P4145, DOI 10.1073/pnas.092136699
   Myhre AG, 2002, J CLIN ENDOCR METAB, V87, P618, DOI 10.1210/jc.87.2.618
   Nabi R, 2004, AM J MED GENET B, V125B, P63, DOI 10.1002/ajmg.b.20147
   Najarian DJ, 2003, J AM ACAD DERMATOL, V48, P805, DOI 10.1067/mjd.2003.540
   Nakamura H, 2008, J ENDOCRINOL INVEST, V31, P861
   Narita Tomohiko, 2011, Allergology International, V60, P505, DOI 10.2332/allergolint.11-OA-0303
   Naslund K, 2005, GENOMICS, V85, P24, DOI 10.1016/j.ygeno.2004.10.009
   Nath SK, 2005, HUM GENET, V118, P225, DOI 10.1007/s00439-005-0044-6
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Neugebauer KM, 2000, ARTHRITIS RHEUM, V43, P1768, DOI 10.1002/1529-0131(200008)43:8<1768::AID-ANR13>3.0.CO;2-9
   Newkirk MM, 2002, CLIN IMMUNOL, V104, P1, DOI 10.1006/clim.2002.5210
   Nguyen CQ, 2009, OCUL SURF, V7, P11
   Nguyen GH, 2003, AM J MED GENET B, V120B, P1, DOI 10.1002/ajmg.b.20010
   Nielsen N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031959
   Nihtyanova SI, 2010, NAT REV RHEUMATOL, V6, P112, DOI 10.1038/nrrheum.2009.238
   Nomura T, 2007, J ALLERGY CLIN IMMUN, V119, P434, DOI 10.1016/j.jaci.2006.12.646
   O'Bleness MS, 2012, G3-GENES GENOM GENET, V2, P977, DOI 10.1534/g3.112.003061
   Okada F, 1999, BRIT J CANCER, V79, P377, DOI 10.1038/sj.bjc.6690060
   Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
   Orozco G, 2006, ANN RHEUM DIS, V65, P687, DOI 10.1136/ard.2005.046094
   Ortona E, 2010, BLOOD, V116, P2960, DOI 10.1182/blood-2010-04-279208
   Ousman SS, 2007, NATURE, V448, P474, DOI 10.1038/nature05935
   PARK DJ, 1995, SCAND J RHEUMATOL, V24, P13
   Park Mi-Hee, 2012, Clin Psychopharmacol Neurosci, V10, P117, DOI 10.9758/cpn.2012.10.2.117
   Parkes M, 2012, DIGEST DIS, V30, P78, DOI 10.1159/000341130
   Penberthy WT, 2009, PPAR RES, DOI 10.1155/2009/853707
   Perron H, 2009, J NEUROL SCI, V286, P65, DOI 10.1016/j.jns.2009.04.034
   Pertovaara M, 2007, CLIN EXP IMMUNOL, V147, P265, DOI 10.1111/j.1365-2249.2006.03278.x
   Phillips AM, 2010, TRAFFIC, V11, P16, DOI 10.1111/j.1600-0854.2009.00999.x
   PLATERZYBERK C, 1985, ARTHRITIS RHEUM, V28, P971, DOI 10.1002/art.1780280903
   Plotz PH, 2003, NAT REV IMMUNOL, V3, P73, DOI 10.1038/nri976
   Poduri A, 2013, SCIENCE, V341, P43, DOI 10.1126/science.1237758
   Pollock W, 1999, J CLIN PATHOL, V52, P684
   Prescott NJ, 2005, TISSUE ANTIGENS, V66, P318, DOI 10.1111/j.1399-0039.2005.00494.x
   Printz DJ, 1999, BIOL PSYCHIAT, V46, P110, DOI 10.1016/S0006-3223(98)00307-2
   Pruitt KD, 2012, NUCLEIC ACIDS RES, V40, pD130, DOI 10.1093/nar/gkr1079
   Quaratino S, 2005, J IMMUNOL, V174, P557
   Quarles RH, 2002, CELL MOL LIFE SCI, V59, P1851, DOI 10.1007/PL00012510
   Rand ML, 2012, J THROMB HAEMOST, V10, P1109, DOI 10.1111/j.1538-7836.2012.04716.x
   Raschi E, 2003, BLOOD, V101, P3495, DOI 10.1182/blood-2002-08-2349
   REEVES WH, 1991, J IMMUNOL, V146, P2678
   Renaudineau Yves, 2011, Keio Journal of Medicine, V60, P10
   Renner M, 2007, GASTROENTEROLOGY, V133, P1499, DOI 10.1053/j.gastro.2007.08.007
   Resta-Lenert S, 2011, AM J PHYSIOL-GASTR L, V300, pG1144, DOI 10.1152/ajpgi.00138.2010
   Robazzi TC, 2013, CLIN EXP RHEUMATOL, V31, P310
   Robazzi TCMV, 2012, REV BRAS REUMATOL, V52, P417
   Rolland A, 2006, J IMMUNOL, V176, P7636
   Rook GAW, 2012, CLIN REV ALLERG IMMU, V42, P5, DOI 10.1007/s12016-011-8285-8
   Rose NR, 2000, CELL MOL LIFE SCI, V57, P542, DOI 10.1007/PL00000716
   ROSENFELD MR, 1993, ANN NEUROL, V33, P113, DOI 10.1002/ana.410330126
   Rosenspire A, 2011, AUTISM RES, V4, P242, DOI 10.1002/aur.194
   Rosenstiel P, 2007, J IMMUNOL, V178, P8203
   Ross KA, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-12
   Roycroft M, 2009, CLIN ENDOCRINOL, V70, P358, DOI 10.1111/j.1365-2265.2008.03380.x
   ROYLE NJ, 1988, GENOMICS, V3, P352, DOI 10.1016/0888-7543(88)90127-9
   Rual JF, 2005, NATURE, V437, P1173, DOI 10.1038/nature04209
   Rueda B, 2005, HUM IMMUNOL, V66, P848, DOI 10.1016/j.humimm.2005.04.008
   Russo D, 1996, J CLIN ENDOCR METAB, V81, P1548, DOI 10.1210/jc.81.4.1548
   Rutjes SA, 1999, CELL DEATH DIFFER, V6, P976, DOI 10.1038/sj.cdd.4400571
   Saccucci P, 2011, CARDIOLOGY, V120, P166, DOI 10.1159/000334808
   Saccucci P, 2011, CARDIOLOGY, V119, P54, DOI 10.1159/000329919
   Sadallah S, 2003, CLIN EXP IMMUNOL, V131, P174, DOI 10.1046/j.1365-2249.2003.02045.x
   Saito Hironobu, 2012, Fukushima J Med Sci, V58, P107
   Sakabe J, 2013, J BIOL CHEM, V288, P17179, DOI 10.1074/jbc.M113.476820
   Salmon M, 1999, RHEUMATOLOGY, V38, P1177, DOI 10.1093/rheumatology/38.12.1177
   Santin I, 2008, TISSUE ANTIGENS, V71, P247, DOI 10.1111/j.1399-0039.2007.01002.x
   Santoni FA, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1001008
   SATO S, 1986, ACTA NEUROL SCAND, V74, P115
   Scanu AM, 2003, NEW ENGL J MED, V349, P2089, DOI 10.1056/NEJMp038128
   Schaap M, 2013, BMC GENOMICS, V14, DOI 10.1186/1471-2164-14-143
   Schaeverbeke T, 2013, JOINT BONE SPINE, V80, P349, DOI 10.1016/j.jbspin.2013.02.005
   SCHIESTL RH, 1994, SCIENCE, V266, P1573, DOI 10.1126/science.7985029
   Schwartz M, 2000, ISRAEL J PSYCHIAT, V37, P32
   Sedman L, 2008, HUM MUTAT, V29, P1181, DOI 10.1002/humu.20767
   Selmi C, 2012, J AUTOIMMUN, V39, P249, DOI 10.1016/j.jaut.2012.07.011
   Semsei I, 2007, ANAL BIOCHEM, V370, P47, DOI 10.1016/j.ab.2007.06.041
   Senecal JL, 1999, ARTHRITIS RHEUM, V42, P1347, DOI 10.1002/1529-0131(199907)42:7<1347::AID-ANR7>3.0.CO;2-#
   Sharp L, 2012, MUSCLE NERVE, V46, P841, DOI 10.1002/mus.23502
   Sherer Y, 2004, SEMIN ARTHRITIS RHEU, V34, P501, DOI 10.1016/j.semarthrit.2004.07.002
   Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
   Shi YS, 2006, MOL CELL, V23, P819, DOI 10.1016/j.molcel.2006.07.022
   Shiari R, 2006, J RHEUMATOL, V33, P1395
   SHMERLING RH, 1991, AM J MED, V91, P528, DOI 10.1016/0002-9343(91)90190-9
   Shukla S, 2011, NATURE, V479, P74, DOI 10.1038/nature10442
   Silbernagel G, 2013, J AM COLL CARDIOL, V62, P291, DOI 10.1016/j.jacc.2013.01.100
   Smith FJD, 2006, NAT GENET, V38, P337, DOI 10.1038/ng1743
   Smyk DS, 2012, INT J RHEUMATOL, V2012
   Smyth DJ, 2008, NEW ENGL J MED, V359, P2767, DOI 10.1056/NEJMoa0807917
   Smyth DJ, 2008, DIABETES, V57, P1730, DOI 10.2337/db07-1131
   Sobajima J, 1999, GUT, V44, P867
   Somers EC, 2009, AM J EPIDEMIOL, V169, P749, DOI 10.1093/aje/kwn408
   Son SW, 2009, BRIT J DERMATOL, V161, P281, DOI 10.1111/j.1365-2133.2009.09178.x
   Song GG, 2013, MOL BIOL REP, V40, P2985, DOI 10.1007/s11033-012-2370-9
   Spurr-Michaud S, 2007, EXP EYE RES, V84, P939, DOI 10.1016/j.exer.2007.01.018
   Stadler MB, 2005, EUR J IMMUNOL, V35, P371, DOI 10.1002/eji.200425481
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Strugala V, 2008, INT J CLIN PRACT, V62, P762, DOI 10.1111/j.1742-1241.2007.01665.x
   Suda S, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-14
   Suzuki S, 2007, ARCH NEUROL-CHICAGO, V64, P1121, DOI 10.1001/archneur.64.8.1121
   TAGGART RT, 1986, AM J HUM GENET, V38, P848
   Takaishi H, 2012, J GASTROENTEROL, V47, P969, DOI 10.1007/s00535-012-0566-3
   Takamori M, 1997, NEUROLOGY, V48, P1261
   Tandon R, 2013, NAT REV CARDIOL, V10, P171, DOI 10.1038/nrcardio.2012.197
   Tatham MH, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2001484
   Tazi J, 2009, BBA-MOL BASIS DIS, V1792, P14, DOI 10.1016/j.bbadis.2008.09.017
   Tebo AE, 2012, PEDIATR RHEUMATOL, V10, DOI 10.1186/1546-0096-10-29
   Teupser D, 2010, CIRC-CARDIOVASC GENE, V3, P331, DOI 10.1161/CIRCGENETICS.109.907873
   Tincani A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-93
   Toes REM, 1996, P NATL ACAD SCI USA, V93, P7855, DOI 10.1073/pnas.93.15.7855
   Toh BH, 2000, IMMUNOL TODAY, V21, P348, DOI 10.1016/S0167-5699(00)01653-4
   Torii S, 2009, ENDOCR J, V56, P639
   Treangen TJ, 2012, NAT REV GENET, V13, P36, DOI 10.1038/nrg3117
   Triolo TM, 2011, DIABETES CARE, V34, P1211, DOI 10.2337/dc10-1756
   Tripathi A, 2009, P NATL ACAD SCI USA, V106, P16799, DOI 10.1073/pnas.0906773106
   Tsirogianni A, 2009, AUTOIMMUN REV, V8, P687, DOI 10.1016/j.autrev.2009.02.019
   Uchida K, 2005, IMMUNOLOGY, V116, P53, DOI 10.1111/j.1365-2567.2005.02197.x
   Ulbricht KU, 2003, AUTOIMMUN REV, V2, P109, DOI 10.1016/S1568-9972(03)00002-8
   Utz PJ, 2000, ARTHRITIS RES, V2, P101
   van de Stadt LA, 2011, ARTHRITIS RHEUM-US, V63, P3226, DOI 10.1002/art.30537
   Vandepoele K, 2005, MOL BIOL EVOL, V22, P2265, DOI 10.1093/molbev/msi222
   van der Woude D, 2010, NAT GENET, V42, P814, DOI 10.1038/ng1010-814
   Vandiedonck C, 2006, ANN NEUROL, V59, P404, DOI 10.1002/ana.20751
   van Schaik FDM, 2013, GUT, V62, P683, DOI 10.1136/gutjnl-2012-302717
   Vierra-Green C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047491
   Villalta D, 2012, AUTOIMMUN REV, V12, P114, DOI 10.1016/j.autrev.2012.07.005
   Vlad G, 2005, J IMMUNOL, V174, P5907
   Vyshkina T, 2008, LAB INVEST, V88, P796, DOI 10.1038/labinvest.2008.53
   Waithe D, 2011, J CELL SCI, V124, P2049, DOI 10.1242/jcs.084988
   Waldman A, 2001, MYCOSES, V44, P77, DOI 10.1046/j.1439-0507.2001.00608.x
   Wang LF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053727
   WANG SJ, 1994, AM J MED GENET, V51, P234, DOI 10.1002/ajmg.1320510313
   Warburton PE, 2008, BMC GENOMICS, V9, DOI 10.1186/1471-2164-9-533
   Wenzlau JM, 2007, P NATL ACAD SCI USA, V104, P17040, DOI 10.1073/pnas.0705894104
   Westra HJ, 2013, NAT GENET, V45, P1238, DOI 10.1038/ng.2756
   White RJ, 2011, NAT REV GENET, V12, P459, DOI 10.1038/nrg3001
   Wickstrom C, 1998, BIOCHEM J, V334, P685
   Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
   WINQVIST O, 1992, LANCET, V339, P1559, DOI 10.1016/0140-6736(92)91829-W
   Witte T, 2000, RHEUMATOL INT, V19, P107, DOI 10.1007/s002960050112
   Wong LP, 2013, AM J HUM GENET, V92, P52, DOI 10.1016/j.ajhg.2012.12.005
   Wongsurawat T, 2012, NUCLEIC ACIDS RES, V40, DOI 10.1093/nar/gkr1075
   Wright C, 2012, MOL CELL PROTEOMICS, V11, DOI 10.1074/mcp.M9.00384
   Xu J, 2012, BMC GENOMICS S8, V13, pS2
   YABE S, 1995, ENDOCR J, V42, P115, DOI 10.1507/endocrj.42.115
   Yamakawa H, 2007, BIOCHEM BIOPH RES CO, V355, P41, DOI 10.1016/j.bbrc.2007.01.127
   Yang F, 2006, CLIN IMMUNOL, V121, P121, DOI 10.1016/j.clim.2006.06.007
   Yauk CL, 2008, ENVIRON MOL MUTAGEN, V49, P26, DOI 10.1002/em.20359
   Zaguia F, 2013, J IMMUNOL, V190, P2510, DOI 10.4049/jimmunol.1202725
   Zampieri S, 2001, ANN RHEUM DIS, V60, P72, DOI 10.1136/ard.60.1.72
   Zavros Y, 2007, J BIOL CHEM, V282, P33265, DOI 10.1074/jbc.M707090200
   Zenewicz LA, 2010, CELL, V140, P791, DOI 10.1016/j.cell.2010.03.003
   Zeng X, 2013, EXP DERMATOL, V22, P679, DOI 10.1111/exd.12233
   Zhang J, 2006, CYTOGENET GENOME RES, V115, P205, DOI 10.1159/000095916
   Zhang JY, 2011, NAT GENET, V43, P902, DOI 10.1038/ng.904
   Zhang XH, 2005, GENE DEV, V19, P827, DOI 10.1101/gad.1286005
   Zhang ZX, 2001, ARTHRITIS RHEUM, V44, P2275, DOI 10.1002/1529-0131(200110)44:10<2275::AID-ART390>3.0.CO;2-K
   Zheng WY, 2013, GENE, V519, P142, DOI 10.1016/j.gene.2013.01.009
   Zhou XD, 2011, ARTHRITIS RES THER, V13, DOI 10.1186/ar3435
   Zlacka D, 2006, J AUTOIMMUN, V27, P81, DOI 10.1016/j.jaut.2006.06.006
   Zoller B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033442
   Zvyagin IV, 2010, CELL MOL IMMUNOL, V7, P471, DOI 10.1038/cmi.2010.42
NR 462
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 2
PY 2014
VL 9
IS 7
AR e101093
DI 10.1371/journal.pone.0101093
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AO5BA
UT WOS:000341354100059
PM 24988487
ER

PT J
AU van de Leemput, J
   Boles, NC
   Kiehl, TR
   Corneo, B
   Lederman, P
   Menon, V
   Lee, C
   Martinez, RA
   Levi, BP
   Thompson, CL
   Yao, SY
   Kaykas, A
   Temple, S
   Fasano, CA
AF van de Leemput, Joyce
   Boles, Nathan C.
   Kiehl, Thomas R.
   Corneo, Barbara
   Lederman, Patty
   Menon, Vilas
   Lee, Changkyu
   Martinez, Refugio A.
   Levi, Boaz P.
   Thompson, Carol L.
   Yao, Shuyuan
   Kaykas, Ajamete
   Temple, Sally
   Fasano, Christopher A.
TI CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral
   Cortex Development from Human Embryonic Stem Cells
SO NEURON
LA English
DT Article
ID MESSENGER-RNA EXPRESSION; CENTRAL-NERVOUS-SYSTEM; CORTICAL DEVELOPMENT;
   HUMAN BRAIN; NEOCORTICAL NEURONOGENESIS; SIGNALING PATHWAY; AUTISM;
   DIFFERENTIATION; NEURONS; GENE
AB Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer understanding of the molecular processes underlying human corticogenesis will provide greater insight into such pathologies. To date, knowledge of gene expression changes accompanying corticogenesis is largely based on murine data. Here we present a searchable, comprehensive, temporal gene expression data set encompassing cerebral cortical development from human embryonic stem cells (hESCs). Using a modified differentiation protocol that yields neurons suggestive of prefrontal cortex, we identified sets of genes and long noncoding RNAs that significantly change during corticogenesis and those enriched for disease-associations. Numerous alternatively spliced genes with varying temporal patterns of expression are revealed, including TGIF1, involved in holoprosencephaly, and MARK1, involved in autism. We have created a database (http://cortecon.neuralsci.org/) that provides online, query-based access to changes in RNA expression and alternatively spliced transcripts during human cortical development.
C1 [van de Leemput, Joyce; Boles, Nathan C.; Kiehl, Thomas R.; Corneo, Barbara; Lederman, Patty; Temple, Sally; Fasano, Christopher A.] Neural Stem Cell Inst, Rensselaer, NY 12144 USA.
   [Kiehl, Thomas R.] SUNY Albany, Coll Comp & Informat, Dept Comp Sci, Albany, NY 12144 USA.
   [Menon, Vilas; Lee, Changkyu; Martinez, Refugio A.; Levi, Boaz P.; Thompson, Carol L.; Yao, Shuyuan; Kaykas, Ajamete] Allen Inst Brain Sci, Seattle, WA 98103 USA.
RP Temple, S (reprint author), Neural Stem Cell Inst, Rensselaer, NY 12144 USA.
EM sallytemple@neuralsci.org; chrisfasano@neuralsci.org
FU NINDS [NS072434-01A1]; Regenerative Research Foundation; Allen Institute
   for Brain Science
FX This work was supported by grants from NINDS (NS072434-01A1 to C. A. F.)
   and the Regenerative Research Foundation. This collaborative work was
   supported in part by the Allen Institute for Brain Science. Its authors
   wish to thank the Allen Institute founders, Paul G. Allen and Jody
   Allen, for their vision, encouragement, and support.
CR Altamura C, 2007, CEREB CORTEX, V17, P1394, DOI 10.1093/cercor/bhl051
   Anders S, 2013, NAT PROTOC, V8, P1765, DOI 10.1038/nprot.2013.099
   Anders S, 2012, GENOME RES, V22, P2008, DOI 10.1101/gr.133744.111
   Anderson BM, 2009, NEUROGENETICS, V10, P209, DOI 10.1007/s10048-009-0171-7
   Belgard TG, 2011, NEURON, V71, P605, DOI 10.1016/j.neuron.2011.06.039
   Bernhardt M, 2012, BIOTECHNOL J, V7, P810, DOI 10.1002/biot.201100347
   Boles NC, 2014, CELL REP, V6, P724, DOI 10.1016/j.celrep.2014.01.026
   CAVINESS VS, 1995, TRENDS NEUROSCI, V18, P379, DOI 10.1016/0166-2236(95)93933-O
   Cecchi C, 2002, GENE, V291, P1, DOI 10.1016/S0378-1119(02)00623-6
   Chalmers AD, 2002, DEV CELL, V2, P171, DOI 10.1016/S1534-5807(02)00113-2
   Chambers SM, 2009, NAT BIOTECHNOL, V27, P275, DOI 10.1038/nbt.1529
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   del Barco Barrantes I., 2003, GENE DEV, V17, P2239
   Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
   Dillman AA, 2013, NAT NEUROSCI, V16, P499, DOI 10.1038/nn.3332
   Dougherty JD, 2005, NEURON, V45, P183, DOI 10.1016/j.neuron.2005.01.007
   El-Jaick KB, 2007, MOL GENET METAB, V90, P97, DOI 10.1016/j.ymgme.2006.07.011
   Fietz SA, 2012, P NATL ACAD SCI USA, V109, P11836, DOI 10.1073/pnas.1209647109
   Forster E, 2010, EUR J NEUROSCI, V31, P1511, DOI 10.1111/j.1460-9568.2010.07222.x
   Frankild S., 2013, DIS DIS GENE ASS MIN
   Garda AL, 2002, NEUROSCIENCE, V113, P689, DOI 10.1016/S0306-4522(02)00171-9
   Gaspard N, 2008, NATURE, V455, P351, DOI 10.1038/nature07287
   Gentleman RC, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-10-r80
   Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101
   Halfon N, 2013, JAMA PEDIATR, V167, P608, DOI 10.1001/jamapediatrics.2013.2188
   Hamid R, 2008, BBA-GENE REGUL MECH, V1779, P347, DOI 10.1016/j.bbagrm.2008.04.003
   Hawrylycz MJ, 2012, NATURE, V489, P391, DOI 10.1038/nature11405
   Hebert JM, 2008, NAT REV NEUROSCI, V9, P678, DOI 10.1038/nrn2463
   Hevner RF, 2001, NEURON, V29, P353, DOI 10.1016/S0896-6273(01)00211-2
   Homer N, 2009, PLOS ONE, V4, pA95, DOI 10.1371/journal.pone.0007767
   Hou PS, 2013, NUCLEIC ACIDS RES, V41, P7753, DOI 10.1093/nar/gkt567
   Hubbard Kyle S, 2013, F1000Res, V2, P35, DOI 10.12688/f1000research.2-35.v1
   Janusonis S, 2004, J NEUROSCI, V24, P1652, DOI 10.1523/JNEUROSCI.4651-03.2004
   Johnson MA, 2007, J NEUROSCI, V27, P3069, DOI 10.1523/JNEUROSCI.4562-06.2007
   Jones EG, 2010, CEREB CORTEX, V20, P2261, DOI 10.1093/cercor/bhq127
   Kaneko T, 2002, NEUROSCI RES, V42, P243, DOI 10.1016/S0168-0102(02)00009-3
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   Kim JE, 2011, P NATL ACAD SCI USA, V108, P3005, DOI 10.1073/pnas.1007753108
   Kumar Lokesh, 2007, Bioinformation, V2, P5
   Lai T, 2008, NEURON, V57, P232, DOI 10.1016/j.neuron.2007.12.023
   Lee AS, 2013, NAT MED, V19, P998, DOI 10.1038/nm.3267
   Mander BA, 2013, NAT NEUROSCI, V16, P357, DOI 10.1038/nn.3324
   Matsumoto M, 2003, NEUROSCIENCE, V116, P127, DOI 10.1016/S0306-4522(02)00556-0
   Maussion G, 2008, HUM MOL GENET, V17, P2541, DOI 10.1093/hmg/ddn154
   Miller JA, 2014, NATURE, V508, P199, DOI 10.1038/nature13185
   Padgett RA, 2012, TRENDS GENET, V28, P147, DOI 10.1016/j.tig.2012.01.001
   Pomarol-Clotet E, 2010, MOL PSYCHIATR, V15, P823, DOI 10.1038/mp.2009.146
   Rice DS, 2001, ANNU REV NEUROSCI, V24, P1005, DOI 10.1146/annurev.neuro.24.1.1005
   Sahara S, 2009, NEURON, V63, P48, DOI 10.1016/j.neuron.2009.06.006
   Scott MM, 2005, INT J DEV NEUROSCI, V23, P277, DOI 10.1016/j.ijdevneu.2004.05.012
   Shen Q, 2006, NAT NEUROSCI, V9, P743, DOI 10.1038/nn1694
   Shi YC, 2012, NAT NEUROSCI, V15, P477, DOI 10.1038/nn.3041
   Takahashi T, 1996, J NEUROSCI, V16, P6183
   Takeuchi A, 2007, CEREB CORTEX, V17, P1531, DOI 10.1093/cercor/bhl064
   Tarca AL, 2009, BIOINFORMATICS, V25, P75, DOI 10.1093/bioinformatics/btn577
   Team RC, 2012, R LANG ENV STAT COMP
   Toyoda R, 2010, DEVELOPMENT, V137, P3439, DOI 10.1242/dev.055392
   Vitalis T, 2007, EUR J NEUROSCI, V26, P331, DOI 10.1111/j.1460-9568.2007.05661.x
   Young MD, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-2-r14
   Zeng HK, 2012, CELL, V149, P483, DOI 10.1016/j.cell.2012.02.052
   Zhang XQ, 2010, CELL STEM CELL, V7, P90, DOI 10.1016/j.stem.2010.04.017
   Zhi-Liang H, 2008, ONLINE J BIOINFORMAT, V9, P108
   Zweifel LS, 2005, NAT REV NEUROSCI, V6, P615, DOI 10.1038/nrn1727
NR 63
TC 5
Z9 6
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD JUL 2
PY 2014
VL 83
IS 1
BP 51
EP 68
DI 10.1016/j.neuron.2014.05.013
PG 18
WC Neurosciences
SC Neurosciences & Neurology
GA AN3HJ
UT WOS:000340476800007
PM 24991954
ER

PT J
AU Yamada, T
   Yang, Y
   Hemberg, M
   Yoshida, T
   Cho, HY
   Murphy, JP
   Fioravante, D
   Regehr, WG
   Gygi, SP
   Georgopoulos, K
   Bonni, A
AF Yamada, Tomoko
   Yang, Yue
   Hemberg, Martin
   Yoshida, Toshimi
   Cho, Ha Young
   Murphy, J. Patrick
   Fioravante, Diasynou
   Regehr, Wade G.
   Gygi, Steven P.
   Georgopoulos, Katia
   Bonni, Azad
TI Promoter Decommissioning by the NuRD Chromatin Remodeling Complex
   Triggers Synaptic Connectivity in the Mammalian Brain
SO NEURON
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; DE-NOVO MUTATIONS; HISTONE DEACETYLASE;
   NEURAL DEVELOPMENT; MI-2/NURD COMPLEX; BREAST-CANCER; GRANULE CELL;
   HUMAN GENOME; STEM-CELLS; DIFFERENTIATION
AB Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. We report that depletion of the NuRD complex by in vivo RNAi and conditional knockout of the core NuRD subunit Chd4 profoundly impairs the establishment of granule neuron parallel fiber/Purkinje cell synapses in the rodent cerebellar cortex in vivo. By interfacing genome-wide sequencing of transcripts and ChIP-seq analyses, we uncover a network of repressed genes and distinct histone modifications at target gene promoters that are developmentally regulated by the NuRD complex in the cerebellum in vivo. Finally, in a targeted in vivo RNAi screen of NuRD target genes, we identify a program of NuRD-repressed genes that operate as critical regulators of presynaptic differentiation in the cerebellar cortex. Our findings define NuRD-dependent promoter decommissioning as a developmentally regulated programming mechanism that drives synaptic connectivity in the mammalian brain.
C1 [Yamada, Tomoko; Yang, Yue; Cho, Ha Young; Bonni, Azad] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA.
   [Yamada, Tomoko; Yang, Yue; Cho, Ha Young; Fioravante, Diasynou; Regehr, Wade G.; Bonni, Azad] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
   [Hemberg, Martin] Childrens Hosp Boston, Dept Ophthalmol, Boston, MA 02115 USA.
   [Yoshida, Toshimi; Georgopoulos, Katia] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA.
   [Gygi, Steven P.] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA.
RP Bonni, A (reprint author), Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA.
EM bonni@wustl.edu
FU NIH [NS041021, AG000222, NS032405, NS007484]; Mathers Foundation; Japan
   Society for the Promotion of Science; NCI [P30 CA91842]; ICTS/CTSA
   [UL1TR000448]
FX We thank members of the Bonni laboratory for helpful discussions and
   critical reading of the manuscript. Supported by NIH grant NS041021 (to
   A. B.), the Mathers Foundation (to A. B.), the Japan Society for the
   Promotion of Science (to T. Yamada), NIH training grant AG000222 (to
   Y.Y.), NIH grant NS032405 (to W. G. R.), and NIH training grant NS007484
   (to D. F.). We thank the Genome Technology Access Center at Washington
   University, which is supported by NCI P30 CA91842 to the Siteman Cancer
   Center and by ICTS/CTSA UL1TR000448.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Darnell RB, 2013, ANNU REV NEUROSCI, V36, P243, DOI 10.1146/annurev-neuro-062912-114322
   de la Torre-Ubieta L, 2011, NEURON, V72, P22, DOI 10.1016/j.neuron.2011.09.018
   Denslow SA, 2007, ONCOGENE, V26, P5433, DOI 10.1038/sj.onc.1210611
   Ebert DH, 2013, NATURE, V493, P327, DOI 10.1038/nature11860
   Fujita N, 2004, CELL, V119, P75, DOI 10.1016/j.cell.2004.09.014
   Funfschilling U, 2002, GENESIS, V33, P160, DOI 10.1002/gene.10104
   Heintzman ND, 2007, NAT GENET, V39, P311, DOI 10.1038/ng1966
   Hong W, 2005, EMBO J, V24, P2367, DOI 10.1038/sj.emboj.7600703
   Ivanov AV, 2007, MOL CELL, V28, P823, DOI 10.1016/j.molcel.2007.11.012
   Kaji K, 2006, NAT CELL BIOL, V8, P285, DOI 10.1038/ncb1372
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Konishi Y, 2004, SCIENCE, V303, P1026, DOI 10.1126/science.1093712
   Kouzarides T, 2007, CELL, V128, P693, DOI 10.1016/j.cell.2007.02.005
   Li B, 2007, CELL, V128, P707, DOI 10.1016/j.cell.2007.01.015
   Li Q, 2011, CANCER RES, V71, P6899, DOI 10.1158/0008-5472.CAN-11-1523
   Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   Palay SL, 1974, CEREBELLAR CORTEX CY
   Rais Y, 2013, NATURE, V502, P65, DOI 10.1038/nature12587
   Reynolds N, 2012, CELL STEM CELL, V10, P583, DOI 10.1016/j.stem.2012.02.020
   Ronan JL, 2013, NAT REV GENET, V14, P347, DOI 10.1038/nrg3413
   Sabatini BL, 1997, J NEUROSCI, V17, P3425
   Schultz DC, 2001, GENE DEV, V15, P428, DOI 10.1101/gad.869501
   Shahbazian MD, 2007, ANNU REV BIOCHEM, V76, P75, DOI 10.1146/annurev.biochem.76.052705.162114
   Shalizi A, 2006, SCIENCE, V311, P1012, DOI 10.1126/science.1122513
   Shcheglovitov A, 2013, NATURE, V503, P267, DOI 10.1038/nature12618
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Uittenbogaard M, 1999, J NEUROSCI RES, V57, P770, DOI 10.1002/(SICI)1097-4547(19990915)57:6<770::AID-JNR2>3.3.CO;2-A
   Vissers LELM, 2004, NAT GENET, V36, P955, DOI 10.1038/ng1407
   Wang Y, 2009, CELL, V138, P660, DOI 10.1016/j.cell.2009.05.050
   Wang ZB, 2009, CELL, V138, P1019, DOI 10.1016/j.cell.2009.06.049
   Wang ZB, 2008, NAT GENET, V40, P897, DOI 10.1038/ng.154
   Whyte WA, 2012, NATURE, V482, P221, DOI 10.1038/nature10805
   Xue YT, 1998, MOL CELL, V2, P851, DOI 10.1016/S1097-2765(00)80299-3
   Yamada T, 2013, J NEUROSCI, V33, P4726, DOI 10.1523/JNEUROSCI.4191-12.2013
   Yang Y, 2009, SCIENCE, V326, P575, DOI 10.1126/science.1177087
   Yoshida T, 2008, GENE DEV, V22, P1174, DOI 10.1101/gad.1642808
   Zhang JW, 2012, NAT IMMUNOL, V13, P86, DOI 10.1038/ni.2150
   Zhang Y, 1997, CELL, V89, P357, DOI 10.1016/S0092-8674(00)80216-0
   Zhang Y, 1998, CELL, V95, P279, DOI 10.1016/S0092-8674(00)81758-4
   Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 45
TC 5
Z9 5
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD JUL 2
PY 2014
VL 83
IS 1
BP 122
EP 134
DI 10.1016/j.neuron.2014.05.039
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA AN3HJ
UT WOS:000340476800012
PM 24991957
ER

PT J
AU Antzoulatos, EG
   Miller, EK
AF Antzoulatos, Evan G.
   Miller, Earl K.
TI Increases in Functional Connectivity between Prefrontal Cortex and
   Striatum during Category Learning
SO NEURON
LA English
DT Article
ID BETA-BAND OSCILLATIONS; BASAL GANGLIA; GRANGER CAUSALITY; CORTICAL
   NETWORK; BRAIN NETWORKS; TOP-DOWN; SYNCHRONIZATION; CATEGORIZATION;
   ATTENTION; MEMORY
AB Functional connectivity between the prefrontal cortex (PFC) and striatum (STR) is thought critical for cognition and has been linked to conditions like autism and schizophrenia. We recorded from multiple electrodes in PFC and STR while monkeys acquired new categories. Category learning was accompanied by an increase in beta band synchronization of LFPs between, but not within, the PFC and STR. After learning, different pairs of PFC-STR electrodes showed stronger synchrony for one or the other category, suggesting category-specific functional circuits. This category-specific synchrony was also seen between PFC spikes and STR LFPs, but not the reverse, reflecting the direct monosynaptic connections from the PFC to STR. However, causal connectivity analyses suggested that the polysynaptic connections from STR to the PFC exerted a stronger overall influence. This supports models positing that the basal ganglia "train'' the PFC. Category learning may depend on the formation of functional circuits between the PFC and STR.
C1 [Antzoulatos, Evan G.; Miller, Earl K.] MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Cambridge, MA 02139 USA.
   [Antzoulatos, Evan G.] Univ Calif Davis, Dept Neurobiol Physiol & Behav, Ctr Neurosci, Davis, CA 95618 USA.
RP Antzoulatos, EG (reprint author), MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, E25-618, Cambridge, MA 02139 USA.
EM eantzoulatos@ucdavis.edu; ekmiller@mit.edu
RI Antzoulatos, Evan/D-3204-2012
OI Antzoulatos, Evan/0000-0002-7366-2078
FU National Institute of Mental Health [5R01MH065252-12]; Picower
   Foundation
FX The authors thank B. Gray, S. Koopman, and D. Ouellette for technical
   assistance; S. Brincat, J. Donoghue, S. Kornblith, R. Loonis, M.
   Lundqvist, M. Moazami, V. Puig, J. Rose, J. Roy, and M. Silver for
   helpful discussions; and M. Wicherski for comments on the manuscript.
   This work was funded by the National Institute of Mental Health
   (5R01MH065252-12) and the Picower Foundation.
CR Antzoulatos EG, 2011, NEURON, V71, P243, DOI 10.1016/j.neuron.2011.05.040
   Arnsten AFT, 2012, NEURON, V76, P223, DOI 10.1016/j.neuron.2012.08.038
   Ashby FG, 2007, PSYCHOL REV, V114, P632, DOI 10.1037/0033-295X.114.3.632
   Brovelli A, 2004, P NATL ACAD SCI USA, V101, P9849, DOI 10.1073/pnas.0308538101
   Buschman TJ, 2012, NEURON, V76, P838, DOI 10.1016/j.neuron.2012.09.029
   Buschman TJ, 2007, SCIENCE, V315, P1860, DOI 10.1126/science.1138071
   Cannon J., 2013, EUR J NEUROSCI, V39, P705, DOI DOI 10.1111/EJN.12453
   Courtemanche R, 2003, J NEUROSCI, V23, P11741
   Daitch AL, 2013, P NATL ACAD SCI USA, V110, P19585, DOI 10.1073/pnas.1307947110
   Daw ND, 2005, NAT NEUROSCI, V8, P1704, DOI 10.1038/nn1560
   Dayan P., 2001, THEORETICAL NEUROSCI
   Dhamala M, 2008, NEUROIMAGE, V41, P354, DOI 10.1016/j.neuroimage.2008.02.020
   Engel AK, 2010, CURR OPIN NEUROBIOL, V20, P156, DOI 10.1016/j.conb.2010.02.015
   Engel AK, 2001, NAT REV NEUROSCI, V2, P704, DOI 10.1038/35094565
   Fries P, 2005, TRENDS COGN SCI, V9, P474, DOI 10.1016/j.tics.2005.08.011
   Fries P, 2009, ANNU REV NEUROSCI, V32, P209, DOI 10.1146/annurev.neuro.051508.135603
   Friston KJ, 2013, CURR OPIN NEUROBIOL, V23, P172, DOI 10.1016/j.conb.2012.11.010
   Gerfen CR, 2011, ANNU REV NEUROSCI, V34, P441, DOI 10.1146/annurev-neuro-061010-113641
   Goldberg JH, 2013, TRENDS NEUROSCI, V36, P695, DOI 10.1016/j.tins.2013.09.001
   Haegens S, 2011, P NATL ACAD SCI USA, V108, P10708, DOI 10.1073/pnas.1107297108
   Hammond C, 2007, TRENDS NEUROSCI, V30, P357, DOI 10.1016/j.tins.2007.05.004
   Hipp JF, 2011, NEURON, V69, P387, DOI 10.1016/j.neuron.2010.12.027
   HOUK JC, 1995, CEREB CORTEX, V5, P95, DOI 10.1093/cercor/5.2.95
   Ito Junji, 2013, Front Syst Neurosci, V7, P1, DOI 10.3389/fnsys.2013.00001
   Lachaux JP, 1999, HUM BRAIN MAPP, V8, P194, DOI 10.1002/(SICI)1097-0193(1999)8:4<194::AID-HBM4>3.0.CO;2-C
   Lerner TN, 2011, CURR OPIN NEUROBIOL, V21, P322, DOI 10.1016/j.conb.2011.01.005
   LYNDBALTA E, 1994, NEUROSCIENCE, V59, P609, DOI 10.1016/0306-4522(94)90181-3
   Ma CF, 2013, COGN NEURODYNAMICS, V7, P253, DOI 10.1007/s11571-012-9239-4
   Marreiros AC, 2012, NEUROIMAGE C, V66C, P301
   Miller E.K., 2008, NEUROSCIENCE RULE GU
   Miller EK, 2013, CURR OPIN NEUROBIOL, V23, P216, DOI 10.1016/j.conb.2012.11.011
   Packard MG, 2002, ANNU REV NEUROSCI, V25, P563, DOI 10.1146/annurev.neuro.25.112701.142937
   Padmanabhan A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00814
   Pasupathy A, 2005, NATURE, V433, P873, DOI 10.1038/nature03287
   Plenz D, 2003, TRENDS NEUROSCI, V26, P436, DOI 10.1016/S0166-2236(03)00196-6
   Puig MV, 2012, NEURON, V74, P874, DOI 10.1016/j.neuron.2012.04.018
   Reber PJ, 1998, P NATL ACAD SCI USA, V95, P747, DOI 10.1073/pnas.95.2.747
   Roberts MJ, 2013, NEURON, V78, P523, DOI 10.1016/j.neuron.2013.03.003
   Schroeder CE, 2009, TRENDS NEUROSCI, V32, P9, DOI 10.1016/j.tins.2008.09.012
   Seger CA, 2008, NEUROSCI BIOBEHAV R, V32, P265, DOI 10.1016/j.neubiorev.2007.07.010
   Seger CA, 2010, ANNU REV NEUROSCI, V33, P203, DOI 10.1146/annurev.neuro.051508.135546
   Seger CA, 2000, NEUROPSYCHOLOGIA, V38, P1316, DOI 10.1016/S0028-3932(00)00014-2
   Siegel M, 2009, P NATL ACAD SCI USA, V106, P21341, DOI 10.1073/pnas.0908193106
   Surmeier DJ, 2005, CURR OPIN NEUROBIOL, V15, P312, DOI 10.1016/j.conb.2005.05.007
   Torrence C, 1998, B AM METEOROL SOC, V79, P61, DOI 10.1175/1520-0477(1998)079<0061:APGTWA>2.0.CO;2
   Uhlhaas Peter J, 2009, Front Integr Neurosci, V3, P17, DOI 10.3389/neuro.07.017.2009
   Uhlhaas PJ, 2012, NEURON, V75, P963, DOI 10.1016/j.neuron.2012.09.004
   Vogels R, 2002, NEUROIMAGE, V16, P401, DOI 10.1006/nimg.2002.1109
   Watrous AJ, 2013, NAT NEUROSCI, V16, P349, DOI 10.1038/nn.3315
   Yoon JH, 2013, BIOL PSYCHIAT, V74, P122, DOI 10.1016/j.biopsych.2012.11.018
NR 50
TC 8
Z9 8
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD JUL 2
PY 2014
VL 83
IS 1
BP 216
EP 225
DI 10.1016/j.neuron.2014.05.005
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA AN3HJ
UT WOS:000340476800019
PM 24930701
ER

PT J
AU Ichikawa, H
   Kitazono, J
   Nagata, K
   Manda, A
   Shimamura, K
   Sakuta, R
   Okada, M
   Yamaguchi, MK
   Kanazawa, S
   Kakigi, R
AF Ichikawa, Hiroko
   Kitazono, Jun
   Nagata, Kenji
   Manda, Akira
   Shimamura, Keiichi
   Sakuta, Ryoichi
   Okada, Masato
   Yamaguchi, Masami K.
   Kanazawa, So
   Kakigi, Ryusuke
TI Novel method to classify hemodynamic response obtained using
   multi-channel fNIRS measurements into two groups: exploring the
   combinations of channels
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE hemodynamic data; near-infrared spectroscopy (NIRS); support vector
   machine (SVM); sparse modeling; attention-deficit/hyperactivity disorder
   (ADHD); autism spectrum disorders (ASD)
ID NEAR-INFRARED SPECTROSCOPY; AUTISM SPECTRUM DISORDER; NEURAL
   REPRESENTATION; FEATURE-SELECTION; INFANT BRAIN; FACE; CHILDREN;
   RECOGNITION; SYMPTOMS; CLASSIFICATION
AB Near-infrared spectroscopy (NIRS) in psychiatric studies has widely demonstrated that cerebral hemodynamics differs among psychiatric patients. Recently we found that children with attention-deficit/hyperactivity disorder (ADHD) and children with autism spectrum disorders (ASD) showed different hemodynamic responses to their own mother's face. Based on this finding, we may be able to classify the hemodynamic data into two those groups and predict to which diagnostic group an unknown participant belongs. In the present study, we proposed a novel statistical method for classifying the hemodynamic data of these two groups. By applying a support vector machine (SVM), we searched the combination of measurement channels at which the hemodynamic response differed between the ADHD and the ASD children. The SVM found the optimal subset of channels in each data set and successfully classified the ADHD data from the ASD data. For the 24-dimensional hemodynamic data, two optimal subsets classified the hemodynamic data with 84% classification accuracy, while the subset contained all 24 channels classified with 62% classification accuracy. These results indicate the potential application of our novel method for classifying the hemodynamic data into two groups and revealing the combinations of channels that efficiently differentiate the two groups.
C1 [Ichikawa, Hiroko; Yamaguchi, Masami K.] Chuo Univ, Dept Psychol, Tokyo 1920393, Japan.
   [Ichikawa, Hiroko; Yamaguchi, Masami K.] Chuo Univ, Res Dev Initiat, Tokyo 1920393, Japan.
   [Ichikawa, Hiroko] Japan Soc Promot Sci, Tokyo, Japan.
   [Kitazono, Jun; Nagata, Kenji; Manda, Akira; Okada, Masato] Univ Tokyo, Dept Complex Sci & Engn, Kashiwa, Chiba, Japan.
   [Shimamura, Keiichi; Sakuta, Ryoichi] Dokkyo Med Univ, Koshigaya Hosp, Dept Pediat, Koshigaya, Japan.
   [Shimamura, Keiichi; Sakuta, Ryoichi] Dokkyo Med Univ, Koshigaya Hosp, Ctr Child Dev & Psychosomat Med, Koshigaya, Japan.
   [Okada, Masato] RIKEN, Brain Sci Inst, Wako, Saitama, Japan.
   [Kanazawa, So] Japan Womens Univ, Dept Psychol, Kawasaki, Kanagawa, Japan.
   [Kakigi, Ryusuke] Natl Inst Physiol Sci, Dept Integrat Physiol, Okazaki, Aichi 444, Japan.
RP Ichikawa, H (reprint author), Chuo Univ, Dept Psychol, 742-1 Higashi Nakano, Tokyo 1920393, Japan.
EM ichihiro@tamacc.chuo-u.ac.jp
FU MEXT KAKENHI [20119002, 23119708]; JSPS KAKENHI [25120009, 26120529,
   25106506, 22700230, 10J06155, 24 7809]
FX This study was supported by Grant-in-Aid for Scientific Research on
   Innovative Areas, "Face perception and recognition" from MEXT KAKENHI
   (20119002 to Masami K. Yamaguchi, 23119708 to Masato Okada);
   Grant-in-Aid for Scientific Research on Innovative Areas, "Sparse
   Modeling" from JSPS KAKENHI (25120009 to Masato Okada and Kenji Nagata,
   26120529 to Hiroko Ichikawa); Grant-in-Aid for Scientific Research on
   Innovative Areas, "Exploring the Limits of Computation (ELC)" from JSPS
   KAKENHI (25106506 to Kenji Nagata); Grant-in-Aid for Scientific Research
   (A) from JSPS KAKENHI (20240020 to Masato Okada); Grant-in-Aid for Young
   Scientists (B) from JSPS KAKENHI (22700230 to Kenji Nagata) and a
   Grant-in-Aid for JSPS Fellows from JSPS KAKENHI (10J06155 to Jun
   Kitazono, 24 7809 to Hiroko Ichikawa).
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bartels A, 2004, NEUROIMAGE, V21, P1155, DOI 10.1016/j.neuroimage.2003.11.003
   Bennett KP, 1992, OPTIMIZATION METHODS, V1, P23, DOI 10.1080/10556789208805504
   Boynton GM, 1996, J NEUROSCI, V16, P4207
   Carlsson J, 2008, ACTA PAEDIATR, V97, P1221, DOI 10.1111/j.1651-2227.2008.00886.x
   CORTES C, 1995, MACH LEARN, V20, P273, DOI 10.1023/A:1022627411411
   Cui Xu, 2011, Neuroimage, V54, P2808, DOI 10.1016/j.neuroimage.2010.10.069
   Cui X, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015474
   Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
   Ernst LH, 2012, J NEAR INFRARED SPEC, V20, P93, DOI 10.1255/jnirs.970
   Ferrari M, 2012, NEUROIMAGE, V63, P921, DOI 10.1016/j.neuroimage.2012.03.049
   Fukuda M., 2009, PSYCHIAT DISORDERS N
   Gervain J, 2011, DEV COGN NEUROS-NETH, V1, P22, DOI 10.1016/j.dcn.2010.07.004
   Gobbini MI, 2007, NEUROPSYCHOLOGIA, V45, P32, DOI 10.1016/j.neuropsychologia.2006.04.015
   Gobbini MI, 2004, NEUROIMAGE, V22, P1628, DOI 10.1016/j.neuroimage.2004.03.049
   Gottemukkula V., 2011, 5th International IEEE/EMBS Conference on Neural Engineering (NER 2011), DOI 10.1109/NER.2011.5910491
   Guyon I., 2003, Journal of Machine Learning Research, V3, DOI 10.1162/153244303322753616
   HILLGER LA, 1991, J COGNITIVE NEUROSCI, V3, P42, DOI 10.1162/jocn.1991.3.1.42
   Ichikawa H, 2010, NEUROSCI LETT, V482, P90, DOI 10.1016/j.neulet.2010.06.086
   Jasper H. H., 1958, ELECTROENCEPHALOGRAP, V10, P371, DOI DOI 10.1016/0013-4694(58)90053-1
   Kitazono J., 2013, THESIS U TOKYO TOKYO
   Kobayashi M, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00153
   Kobayashi M, 2012, NEUROREPORT, V23, P984, DOI 10.1097/WNR.0b013e32835a4b86
   Kohavi R., 1995, P 14 INT JOINT C ART, V2, P1137
   Liu H, 2005, IEEE T KNOWL DATA EN, V17, P491
   Lloyd-Fox S, 2010, NEUROSCI BIOBEHAV R, V34, P269, DOI 10.1016/j.neubiorev.2009.07.008
   Monden Y, 2012, NEUROIMAGE-CLIN, V1, P131, DOI 10.1016/j.nicl.2012.10.001
   Nakato E, 2011, NEUROIMAGE, V54, P1600, DOI 10.1016/j.neuroimage.2010.09.021
   Negoro H, 2010, CHILD PSYCHIAT HUM D, V41, P193, DOI 10.1007/s10578-009-0160-y
   Ramasubbu R, 2007, CAN J PSYCHIAT, V52, P726
   Rossion B, 2000, J COGNITIVE NEUROSCI, V12, P793, DOI 10.1162/089892900562606
   Saxe R, 2003, NEUROIMAGE, V19, P1835, DOI 10.1016/S1053-8119(03)00230-1
   Schecklmann M, 2010, J PSYCHIATR RES, V44, P621, DOI 10.1016/j.jpsychires.2009.11.018
   Schroeter ML, 2003, NEUROIMAGE, V19, P555, DOI 10.1016/S1053-8119(03)00155-1
   Scott LS, 2006, PERCEPTION, V35, P1107, DOI 10.1068/p5493
   Shimada S, 2006, NEUROIMAGE, V32, P930, DOI 10.1016/j.neuroimage.2006.03.044
   Shimamura K., 2012, P 54 ANN M JAP SOC C, pS206
   Singh AK, 2006, NEUROIMAGE, V33, P542, DOI 10.1016/j.neuroimage.2006.06.047
   Sitaram R, 2007, NEUROIMAGE, V34, P1416, DOI 10.1016/j.neuroimage.2006.11.005
   Strangman G, 2003, NEUROIMAGE, V18, P865, DOI 10.1016/S1053-8119(03)00021-1
   Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
   Thorell LB, 2012, ATTACH HUM DEV, V14, P517, DOI 10.1080/14616734.2012.706396
   Tibshirani R, 1996, J ROY STAT SOC B MET, V58, P267
   Tye C, 2013, DEV COGN NEUROS-NETH, V5, P71, DOI 10.1016/j.dcn.2013.01.001
   van der Meer JMJ, 2012, J AM ACAD CHILD PSY, V51, P1160, DOI 10.1016/j.jaac.2012.08.024
   Vapnik V, 1982, ESTIMATION DEPENDENC
   Weber P, 2005, J DEV BEHAV PEDIATR, V26, P105, DOI 10.1097/00004703-200504000-00005
   Weston J, 2001, ADV NEUR IN, V13, P668
   Yamashita O, 2008, NEUROIMAGE, V42, P1414, DOI 10.1016/j.neuroimage.2008.05.050
   Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
   Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1
NR 51
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JUL 2
PY 2014
VL 8
AR 480
DI 10.3389/fnhum.2014.00480
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA AM7MZ
UT WOS:000340053100001
PM 25071510
ER

PT J
AU Dekker, V
   Nauta, MH
   Mulder, EJ
   Timmerman, ME
   de Bildt, A
AF Dekker, Vera
   Nauta, Maaike H.
   Mulder, Erik J.
   Timmerman, Marieke E.
   de Bildt, Annelies
TI A randomized controlled study of a social skills training for
   preadolescent children with autism spectrum disorders: generalization of
   skills by training parents and teachers?
SO BMC PSYCHIATRY
LA English
DT Article
DE Social skills training; Autism spectrum disorder; RCT; Primary school;
   Treatment efficacy
ID HIGH-FUNCTIONING AUTISM; ASPERGERS-SYNDROME; INTERVENTION; PROGRAM;
   EFFICACY
AB Background: Social skills training (SST) is a common intervention for children with autism spectrum disorders (ASDs) to improve their social and communication skills. Despite the fact that SSTs are often applied in clinical practice, the evidence for the effectiveness of these trainings for children with ASD is inconclusive. Moreover, long term outcome and generalization of learned skills are little evaluated. Additionally, there is no research on the influence of involvement of parents and teachers on effectiveness of SST and on the generalization of learned social skills to daily life. We expect parent and teacher involvement in SST to enhance treatment efficacy and to facilitate generalization of learned skills to daily life.
   Method/Design: In a randomized controlled trial (RCT) with three conditions, 120 participants with ASD at the end of primary school (10-12 years of calendar age) have been randomized to SST, SST-PTI SST with Parent & Teacher Involvement), or care-as-usual. The SST consists of 18 group sessions of 1.5 hours for the children. In the SST-PTI condition, parents additionally participate in 8 parent sessions and parents and teachers are actively involved in homework assignments. Assessment takes place at three moments: before and immediately after the intervention period and at 6 months follow-up. Primary outcome is socialization, as an aspect of adaptive functioning. Secondary outcomes focus on specific social skills children learn during SST and on more general social skills pertaining to home and community settings from a multi informant perspective. Additionally, possible predictors of treatment outcome will be assessed.
   Discussion: The current study is an RCT study evaluating SST in a large sample of Dutch children with ASD in a specific age range (10-12 years). Strengths of the study are the use of one manualized protocol, application of standardized and internationally used rating instruments, use of multiple raters, investigation of generalization of learned skills to daily life, and the evaluation of efficacy in the longer term by follow-up measures at 6 months after the end of training.
C1 [Dekker, Vera; Nauta, Maaike H.; Mulder, Erik J.; de Bildt, Annelies] Univ Groningen, Univ Med Ctr Groningen, Accare Groningen, Dept Child & Adolescent Psychiat, NL-9700 RB Groningen, Netherlands.
   [Nauta, Maaike H.; Timmerman, Marieke E.] Univ Groningen, Dept Clin Psychol, NL-9712 TS Groningen, Netherlands.
RP Dekker, V (reprint author), Univ Groningen, Univ Med Ctr Groningen, Accare Groningen, Dept Child & Adolescent Psychiat, Hanzepl 1, NL-9700 RB Groningen, Netherlands.
EM v.dekker@accare.nl
FU Netherlands Organization for Health Research and Development (ZonMw)
   [157003005]
FX This study has been funded by the Netherlands Organization for Health
   Research and Development (ZonMw, nr 157003005). Barbara van den
   Hoofdakker, Lianne van der Veen, Sjoukje van Warners, and Leonieke Vet
   have developed the intervention protocols used in the study.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
   De Bildt A, 2008, AUTISME DIAGNOSTISCH
   De Bildt AA, 2003, SOCIALE REDZAAMHEID
   De Jonge MV, 2007, AUTISME DIAGNOSTISCH
   DeRosier ME, 2011, J AUTISM DEV DISORD, V41, P1033, DOI 10.1007/s10803-010-1128-2
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
   Forness SR, 1999, LEARNING DISABILITY, V19, P2
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Freitag CM, 2013, TRAILS, V14
   Gillies Donna, 2013, Evid Based Child Health, V8, P316, DOI 10.1002/ebch.1902
   Gresham F. M., 1990, SOCIAL SKILLS RATING
   Herbrecht E, 2009, EUR CHILD ADOLES PSY, V18, P327, DOI 10.1007/s00787-008-0734-4
   Karkhaneh M, 2010, AUTISM, V14, P641, DOI 10.1177/1362361310373057
   Koenig K, 2010, J AUTISM DEV DISORD, V40, P1209, DOI 10.1007/s10803-010-0979-x
   Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5
   Lauritsen MB, 2013, EUR CHILD ADOLES PSY, V22, pS37, DOI 10.1007/s00787-012-0359-5
   Lopata C, 2010, J AUTISM DEV DISORD, V40, P1297, DOI 10.1007/s10803-010-0989-8
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
   Owens G, 2008, J AUTISM DEV DISORD, V38, P1944, DOI 10.1007/s10803-008-0590-6
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Reichow Brian, 2013, Evid Based Child Health, V8, P266, DOI 10.1002/ebch.1903
   Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
   Rutter M., 2003, ADI R AUTISM DIAGNOS
   Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Spence SH, 2000, J CHILD PSYCHOL PSYC, V41, P713, DOI 10.1017/S0021963099005934
   Volkmar F. R., 2005, HDB AUTISM PERVASIVE
   White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
   Yoo HJ, AUTISM RES
NR 34
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUL 2
PY 2014
VL 14
AR 189
DI 10.1186/1471-244X-14-189
PG 13
WC Psychiatry
SC Psychiatry
GA AL4PT
UT WOS:000339115600001
PM 24989854
ER

PT J
AU Smith, JD
   Rho, JM
   Masino, SA
   Mychasiuk, R
AF Smith, Jacklyn D.
   Rho, Jong M.
   Masino, Susan A.
   Mychasiuk, Richelle
TI Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3(tf/)J Mouse
   Model of Autism
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Behavior; Issue 89; mice; inbred C57BL; social behavior; animal models;
   autism; BTBR; motor stereotypy; repetitive
ID BEHAVIORS; MICE; ANXIETY
AB Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental disorder characterized by decreased reciprocal social interaction, abnormal communication, and repetitive behaviors with restricted interest. As diagnosis is based on clinical criteria, any potentially relevant rodent models of this heterogeneous disorder should ideally recapitulate these diverse behavioral traits. The BTBR T+ Itpr(3tf)/J (BTBR) mouse is an established animal model of ASD, displaying repetitive behaviors such as increased grooming, as well as cognitive inflexibility. With respect to social interaction and interest, the juvenile play test has been employed in multiple rodent models of ASD. Here, we show that when BTBR mice are tested in a juvenile social interaction enclosure containing sawdust bedding, they display a repetitive synchronous digging motion. This repetitive motor behavior, referred to as "inchworming," was named because of the stereotypic nature of the movements exhibited by the mice while moving horizontally across the floor. Inchworming mice must use their fore- and hind-limbs in synchrony to displace the bedding, performing a minimum of one inward and one outward motion. Although both BTBR and C56BL/6J (B6) mice exhibit this behavior, BTBR mice demonstrate a significantly higher duration and frequency of inchworming and a decreased latency to initiate inchworming when placed in a bedded enclosure. We conclude that this newly described behavior provides a measure of a repetitive motor stereotypy that can be easily measured in animal models of ASD.
C1 [Smith, Jacklyn D.; Rho, Jong M.; Mychasiuk, Richelle] Univ Calgary, Fac Med, Alberta Childrens Hosp, Res Inst,Dept Paediat & Clin Neurosci, Calgary, AB T2N 1N4, Canada.
   [Masino, Susan A.] Trin Coll, Dept Psychol, Neurosci Program, Cambridge, England.
RP Mychasiuk, R (reprint author), Univ Calgary, Fac Med, Alberta Childrens Hosp, Res Inst,Dept Paediat & Clin Neurosci, Calgary, AB T2N 1N4, Canada.
EM rmmychas@ucalgary.ca
FU Alberta Children's Hospital Foundation; Alberta Children's Hospital
   Research Institute
FX The authors are grateful for the technical and logistical assistance and
   expertise provided by Rose Tobias, Younghee Ahn, and David N. Ruskin.
   The work described here was funded by the Alberta Children's Hospital
   Foundation and the Alberta Children's Hospital Research Institute.
CR Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
   Deacon RMJ, 2005, BEHAV BRAIN RES, V156, P241, DOI 10.1016/j.bbr.2004.05.027
   Deacon RMJ, 2006, NAT PROTOC, V1, P122, DOI 10.1038/nprot.2006.20
   DUDEK BC, 1983, J COMP PSYCHOL, V97, P249, DOI 10.1037/0735-7036.97.3.249
   Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x
   Pobbe RLH, 2010, BEHAV BRAIN RES, V214, P443, DOI 10.1016/j.bbr.2010.06.025
   Pobbe RLH, 2011, BEHAV BRAIN RES, V216, P446, DOI 10.1016/j.bbr.2010.08.039
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   WEBSTER DG, 1981, ANIM LEARN BEHAV, V9, P173, DOI 10.3758/BF03197816
NR 12
TC 0
Z9 0
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUL
PY 2014
IS 89
AR e50791
DI 10.3791/50791
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CB0DR
UT WOS:000349296100005
ER

PT J
AU Farah, R
   Schmithorst, VJ
   Keith, RW
   Holland, SK
AF Farah, Rola
   Schmithorst, Vincent J.
   Keith, Robert W.
   Holland, Scott K.
TI Altered white matter microstructure underlies listening difficulties in
   children suspected of auditory processing disorders: a DTI study
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE Attention; auditory processing disorder; dichotic listening; diffusion
   tensor imaging; listening difficulties
ID DEFICIT-HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDER;
   CORPUS-CALLOSUM; LANGUAGE LATERALIZATION; HUMAN BRAIN; SPEECH
   LATERALIZATION; COGNITIVE CONTROL; SPINAL-CORD; DIFFUSION; ATTENTION
AB Introduction: The purpose of the present study was to identify biomarkers of listening difficulties by investigating white matter microstructure in children suspected of auditory processing disorder (APD) using diffusion tensor imaging (DTI). Behavioral studies have suggested that impaired cognitive and/or attention abilities rather than a pure sensory processing deficit underlie listening difficulties and auditory processing disorder (APD) in children. However, the neural signature of listening difficulties has not been investigated. Methods: Twelve children with listening difficulties and atypical left ear advantage (LEA) in dichotic listening and twelve age- and gender-matched typically developing children with typical right ear advantage (REA) were tested. Using voxel-based analysis, fractional anisotropy (FA), and mean, axial and radial diffusivity (MD, AD, RD) maps were computed and contrasted between the groups. Results: Listening difficulties were associated with altered white matter microstructure, reflected by decreased FA in frontal multifocal white matter regions centered in prefrontal cortex bilaterally and left anterior cingulate. Increased RD and decreased AD accounted for the decreased FA, suggesting delayed myelination in frontal white matter tracts and disrupted fiber organization in the LEA group. Furthermore, listening difficulties were associated with increased MD (with increase in both RD and AD) in the posterior limb of the internal capsule (sublenticular part) at the auditory radiations where auditory input is transmitted between the thalamus and the auditory cortex. Conclusions: Our results provide direct evidence that listening difficulties in children are associated with altered white matter microstructure and that both sensory and supramodal deficits underlie the differences between the groups.
C1 [Farah, Rola] Cincinnati Childrens Hosp Med Ctr, Commun Sci Res Ctr, Cincinnati, OH 45229 USA.
   [Farah, Rola; Keith, Robert W.] Univ Cincinnati, Coll Allied Hlth Sci, Dept Commun Sci & Disorders, Cincinnati, OH USA.
   [Schmithorst, Vincent J.] UPMC, Childrens Hosp Pittsburgh, Dept Radiol, Pittsburgh, PA USA.
   [Holland, Scott K.] Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Pediat Neuroimaging Res Consortium, Cincinnati, OH 45229 USA.
RP Farah, R (reprint author), Cincinnati Childrens Hosp Med Ctr, Commun Sci Res Ctr, 3333 Burnet Ave, Cincinnati, OH 45229 USA.
EM Rola.farrah@cchmc.org
FU University of Cincinnati Research Council grant; Imaging Research Center
   at Cincinnati Children's Hospital Medical Center
FX This work was supported in part by a University of Cincinnati Research
   Council grant and by the Imaging Research Center at Cincinnati
   Children's Hospital Medical Center.
CR Alexander AL, 2007, NEUROTHERAPEUTICS, V4, P316, DOI 10.1016/j.nurt.2007.05.011
   American Academy of Audiology, 2010, GUID DIAGN TREATM MA
   American Speech-Language-Hearing Association, 2005, CENTR AUD PROC DIS
   Ashtari M, 2005, BIOL PSYCHIAT, V57, P448, DOI 10.1016/j.biopsych.2004.11.047
   Assaf Y, 2008, J MOL NEUROSCI, V34, P51, DOI 10.1007/s12031-007-0029-0
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   BASSER PJ, 1994, BIOPHYS J, V66, P259
   Beaulieu C, 2002, NMR BIOMED, V15, P435, DOI 10.1002/nbm.782
   Behrens TEJ, 2003, NAT NEUROSCI, V6, P750, DOI 10.1038/nn1075
   Behrens TEJ, 2007, NEUROIMAGE, V34, P144, DOI 10.1016/j.neuroimage.2006.09.018
   Berman JI, 2013, AM J NEURORADIOL, V34, P1573, DOI 10.3174/ajnr.A3471
   Bloemen OJN, 2010, AUTISM RES, V3, P203, DOI 10.1002/aur.146
   Bockhorst KH, 2008, J NEUROSCI RES, V86, P1520, DOI 10.1002/jnr.21607
   Bryden M. P., 1988, HDB DICHOTIC LISTENI, P1
   BRYDEN MP, 1983, BRAIN LANG, V18, P236, DOI 10.1016/0093-934X(83)90018-4
   Budde MD, 2009, J NEUROSCI, V29, P2805, DOI 10.1523/JNEUROSCI.4605-08.2009
   Cacace Anthony T, 2005, Am J Audiol, V14, P112, DOI 10.1044/1059-0889(2005/012)
   Cacace AT, 2013, J AM ACAD AUDIOL, V24, P572, DOI 10.3766/jaaa.24.7.6
   Casey BJ, 2007, AM J PSYCHIAT, V164, P1729, DOI 10.1176/appi.ajp.2007.06101754
   Christensen TA, 2008, NEUROREPORT, V19, P1101, DOI 10.1097/WNR.0b013e3283060a9d
   Dosenbach NUF, 2006, NEURON, V50, P799, DOI 10.1016/j.neuron.2006.04.031
   Dubois J, 2008, HUM BRAIN MAPP, V29, P14, DOI 10.1002/hbm.20363
   Ferguson MA, 2011, J SPEECH LANG HEAR R, V54, P211, DOI 10.1044/1092-4388(2010/09-0167)
   Fields RD, 2008, TRENDS NEUROSCI, V31, P361, DOI 10.1016/j.tins.2008.04.001
   Frith U., 1989, AUTISM EXPLAINING EN
   Fritz JB, 2007, CURR OPIN NEUROBIOL, V17, P437, DOI 10.1016/j.conb.2007.07.011
   GIEDD JN, 1994, AM J PSYCHIAT, V151, P665
   Harsan LA, 2006, J NEUROSCI RES, V83, P392, DOI 10.1002/jnr.20742
   Hugdahl K, 2003, COGNITIVE BRAIN RES, V16, P58, DOI 10.1016/S0926-6410(02)00210-0
   Hugdahl K, 2003, ASYMMETRICAL BRAIN, P441
   HYND GW, 1991, J LEARN DISABIL, V24, P141
   Jerger J, 2006, J AM ACAD AUDIOL, V17, P2
   Jerger James, 2004, J Am Acad Audiol, V15, P79, DOI 10.3766/jaaa.15.1.8
   Keith R., 2009, SCAN 3 CHILDREN TEST
   Keith R. W., 1984, AUDITION CHILDREN ME
   Keith R. W., 2007, HDB CENTRAL AUDITORY, P207
   Kim JH, 2006, NEUROBIOL DIS, V21, P626, DOI 10.1016/j.nbd.2005.09.009
   Kim SE, 2013, J NEUROPHYSIOL, V110, P1621, DOI 10.1152/jn.00117.2013
   KIMURA D, 1963, Acta Otolaryngol, V56, P617, DOI 10.3109/00016486309127458
   KIMURA D, 1963, J COMP PHYSIOL PSYCH, V56, P899, DOI 10.1037/h0047762
   Knecht S, 2000, BRAIN, V123, P74, DOI 10.1093/brain/123.1.74
   Konrad A, 2010, EUR J NEUROSCI, V31, P912, DOI 10.1111/j.1460-9568.2010.07110.x
   Lancaster JL, 1997, HUM BRAIN MAPP, V5, P238, DOI 10.1002/(SICI)1097-0193(1997)5:4&lt;238::AID-HBM6&gt;3.0.CO;2-4
   Lawrence KE, 2013, J AM ACAD CHILD PSY, V52, P431, DOI 10.1016/j.jaac.2013.01.010
   Lebedev MA, 2004, PLOS BIOL, V2, P1919, DOI 10.1371/journal.pbio.0020365
   Lebel C, 2008, NEUROIMAGE, V40, P1044, DOI 10.1016/j.neuroimage.2007.12.053
   Le Bihan D, 2001, J MAGN RESON IMAGING, V13, P534, DOI 10.1002/jmri.1076
   Liston C, 2011, BIOL PSYCHIAT, V69, P1168, DOI 10.1016/j.biopsych.2011.03.022
   LORING DW, 1990, NEUROPSYCHOLOGIA, V28, P831, DOI 10.1016/0028-3932(90)90007-B
   MacDonald AW, 2000, SCIENCE, V288, P1835, DOI 10.1126/science.288.5472.1835
   Makris N, 2008, CEREB CORTEX, V18, P1210, DOI 10.1093/cercor/bhm156
   Moncrieff DW, 2011, BRAIN COGNITION, V76, P316, DOI 10.1016/j.bandc.2011.03.013
   Moore D. R., 2013, HEARING BALANCE COMM, P1
   Moore DR, 2010, PEDIATRICS, V126, pE382, DOI 10.1542/peds.2009-2826
   Moore D.R., 2006, AUDIOLOGICAL MED, V4, P4, DOI DOI 10.1080/16513860600568573
   Moore DR, 2013, INT J AUDIOL, V52, P3, DOI 10.3109/14992027.2012.723143
   Moore JK, 2001, JARO, V2, P297, DOI 10.1007/s101620010052
   Musiek FE, 2011, BRAIN COGNITION, V76, P225, DOI 10.1016/j.bandc.2011.03.011
   Nagel BJ, 2011, J AM ACAD CHILD PSY, V50, P283, DOI 10.1016/j.jaac.2010.12.003
   Neil J, 2002, NMR BIOMED, V15, P543, DOI 10.1002/nbm.784
   O'Leary D. S., 2002, ASYMMETRICAL BRAIN, P477
   Oishi K., 2010, MRI ATLAS HUMAN WHIT
   Owen JP, 2013, NEUROIMAGE-CLIN, V2, P844, DOI 10.1016/j.nicl.2013.06.009
   Paus T, 2005, TRENDS COGN SCI, V9, P60, DOI 10.1016/j.tics.2004.12.008
   Schmithorst VJ, 2011, EAR HEARING, V32, P156, DOI 10.1097/AUD.0b013e3181f7a481
   Schmithorst VJ, 2013, NEUROIMAGE-CLIN, V3, P8, DOI 10.1016/j.nicl.2013.06.016
   Sharma M, 2009, J SPEECH LANG HEAR R, V52, P706, DOI 10.1044/1092-4388(2008/07-0226)
   Shaywitz BA, 2001, NEUROIMAGE, V13, P601, DOI 10.1006/nimg.2000.0726
   Shukla DK, 2010, J AM ACAD CHILD PSY, V49, P1269, DOI 10.1016/j.jaac.2010.08.018
   Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267
   Sutcliffe PA, 2006, J SPEECH LANG HEAR R, V49, P1072, DOI 10.1044/1092-4388(2006/076)
   Szaflarski JP, 2012, BRAIN RES, V1433, P85, DOI 10.1016/j.brainres.2011.11.026
   Takio F, 2009, DEV NEUROPSYCHOL, V34, P225, DOI 10.1080/87565640902805669
   The British Society of Audiology and the UK APD Steering Group, 2011, POS STAT AUD PROC DI
   Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
   Tyszka JM, 2006, NEUROIMAGE, V29, P1058, DOI 10.1016/j.neuroimage.2005.08.037
   Vandermosten M, 2012, NEUROSCI BIOBEHAV R, V36, P1532, DOI 10.1016/j.neubiorev.2012.04.002
   Westerhausen R, 2010, NEUROPSYCHOLOGIA, V48, P2075, DOI 10.1016/j.neuropsychologia.2010.03.028
   Westerhausen R, 2008, NEUROSCI BIOBEHAV R, V32, P1044, DOI 10.1016/j.neubiorev.2008.04.005
   Wu CT, 2007, BRAIN RES, V1134, P187, DOI 10.1016/j.brainres.2006.11.088
   YAZGAN MY, 1995, NEUROPSYCHOLOGIA, V33, P769, DOI 10.1016/0028-3932(95)00018-X
   ZATORRE RJ, 1989, NEUROPSYCHOLOGIA, V27, P1207, DOI 10.1016/0028-3932(89)90033-X
NR 82
TC 0
Z9 0
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD JUL
PY 2014
VL 4
IS 4
BP 531
EP 543
DI 10.1002/brb3.237
PG 13
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AX5NQ
UT WOS:000346973900008
PM 25161820
ER

PT J
AU Keselman, A
   Smith, CA
   Hundal, S
AF Keselman, Alla
   Smith, Catherine Arnott
   Hundal, Savreen
TI Library workers' personal beliefs about childhood vaccination and
   vaccination information provision
SO JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION
LA English
DT Article
ID CHILDREN; PARENTS
AB This is a report on the impact of library workers' personal beliefs on provision of vaccination information. Nine public librarians were interviewed about a hypothetical scenario involving a patron who is concerned about possible vaccination-autism connections. The analysis employed thematic coding. Results suggested that while most participants supported childhood vaccination, tension between their personal views and neutrality impacted their ability to conduct the interaction. The neutrality stance, though consonant with professional guidelines, curtails librarians' ability to provide accurate health information. Outreach and communication between public and health sciences libraries can help librarians provide resources to address health controversies.
C1 [Keselman, Alla] US Natl Lib Med, Div Specialized Informat Serv, Bethesda, MD 20892 USA.
   [Smith, Catherine Arnott] Univ Wisconsin, Sch Lib & Informat Studies, Madison, WI 53706 USA.
   [Hundal, Savreen] Ctr Publ Serv Commun, Claiborne, MD 21624 USA.
RP Keselman, A (reprint author), US Natl Lib Med, Div Specialized Informat Serv, 6707 Democracy Blvd,Suite 510, Bethesda, MD 20892 USA.
EM keselmana@mail.nih.gov; casmith24@wisc.edu; savreenhundal@gmail.com
CR Anderson AJ, 1990, LIB J, P115
   Baker Lynda M, 2007, Issues Compr Pediatr Nurs, V30, P39, DOI 10.1080/01460860701366666
   Flaherty MG, 2011, PUBLIC LIB Q, V30, P117
   Gullion JS, 2008, PUBLIC HEALTH NURS, V25, P401, DOI 10.1111/j.1525-1446.2008.00724.x
   Hampton T, 2011, JAMA-J AM MED ASSOC, V306, P2440, DOI 10.1001/jama.2011.1756
   Highby W., 2005, LIB COLL ACQ TECH SE, V28, P465
   Kennedy A, 2011, PEDIATRICS, V127, pS92, DOI 10.1542/peds.2010-1722N
   Kennedy AM, 2005, PUBLIC HEALTH REP, V120, P252
   Lee R, 2007, INFORM SEARCHES SOLV
   Malizia M, 2012, PUB LIB, V51, P32
   Smith B., 2012, CHICAGO MAGAZIN 0212
   Smith CA, 2014, J CONS HLTH IN PRESS
   Smith C. A., 2011, Journal of Consumer Health on the Internet, V15, P149, DOI 10.1080/15398285.2011.573339
   Smith PJ, 2004, PEDIATRICS, V114, P187, DOI 10.1542/peds.114.1.187
   Spivak C D, 1902, Med Lib, V5, P17
   US Food and Drug Administration, 2011, INSP COMPL ENF CRIM
NR 16
TC 0
Z9 0
PU MEDICAL LIBRARY ASSOC
PI CHICAGO
PA 65 EAST WACKER PLACE, STE 1900, CHICAGO, IL 60601-7298 USA
SN 1536-5050
J9 J MED LIBR ASSOC
JI J. Med. Libr. Assoc.
PD JUL
PY 2014
VL 102
IS 3
BP 205
EP U73
DI 10.3163/1536-5050.102.3.012
PG 6
WC Information Science & Library Science
SC Information Science & Library Science
GA AW2UW
UT WOS:000346145700012
PM 25031563
ER

PT J
AU Sen, F
   Oksar, RE
   Golkarian, M
   Yaldiz, S
AF Sen, Fatih
   Oksar, Rustu Efe
   Golkarian, Mina
   Yaldiz, Sevde
TI Quality Changes of Different Sweet Cherry Cultivars at Various Stages of
   the Supply Chain
SO NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
LA English
DT Article
DE antioxidants; firmness; marketing pitting; Prunus autism L;
   transportation
ID PRUNUS-AVIUM L.; ANTIOXIDANT ACTIVITY; SHELF-LIFE; BING CHERRIES;
   COLD-STORAGE; ATMOSPHERES; FRAP
AB Transportation of sweet cherry fruits to distant markets and further marketing processes often takes approximately 2-3 weeks. The present study investigates the quality changes during this time period at three stages for three sweet cherry cultivars: 'Early Burlat', 'Napoleon', and '0900 Ziraat'. Following pre-cooling, the sweet cherries were placed in modified atmosphere packages and exposed to the following stages for the indicated durations: transportation (T) [8 days at 2 C and 85% relative humidity (RH)]; distribution center (DC) (4 days at 6.5 C and 80% RH), and shelf-life (SL) (2 days at 19 C and 70% RH). Weight losses at the end of the SL stage were 3.11, 3.18, and 2.74%, respectively in 'Early Burlat', 'Napoleon' and '0900 Ziraai. Fruit firmness decreased after SL as compared CO that at other stages and was more remarkable in '0900 Ziraat'. Decreased Chroma values which indicates, the intensity or color saturation were observed in all cultivars, whereas decreased hue angle values colours expressed in degrees were observed in the 'Early Burlat' and '0900 Ziraat'. In addition, a decrease was noted in the titratable acidity of all cultivars at the end of SL. The total soluble solids, total phenolic content, and antioxidant activities were similar for all cultivars at all stages. The visual appearance scores of 'Early Burlat' cherries decreased at the end of SL, because of development of pitting on the fruit surface. The fruit quality changes were limited at T and DC stages; however, these changes became more distinctive during the SL period. It was thus concluded that the SL duration and conditions were of the highest significance with regard to maintenance of the sweet cherry fruit quality.
C1 [Sen, Fatih; Oksar, Rustu Efe; Golkarian, Mina; Yaldiz, Sevde] Ege Univ, Fac Agr, Dept Hort, TR-35100 Izmir, Turkey.
RP Sen, F (reprint author), Ege Univ, Fac Agr, Dept Hort, TR-35100 Izmir, Turkey.
EM fsenmacar@gmail.com
CR Alique R, 2005, POSTHARVEST BIOL TEC, V35, P153, DOI 10.1016/j.postharvbio.2004.07.003
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Bernalte MJ, 1999, J FOOD QUALITY, V22, P403, DOI 10.1111/j.1745-4557.1999.tb00173.x
   Bernalte MJ, 2003, POSTHARVEST BIOL TEC, V28, P303, DOI 10.1016/S0925-5214(02)00194-1
   Burkhardt S, 2001, J AGR FOOD CHEM, V49, P4898, DOI 10.1021/jf010321+
   Clayton M, 2003, HORTSCIENCE, V38, P407
   Crisosto CH, 2003, POSTHARVEST BIOL TEC, V28, P159, DOI 10.1016/S0925-5214(02)00173-4
   Diaz-Mula HM, 2009, FOOD SCI TECHNOL INT, V15, P535, DOI 10.1177/1082013209351868
   Esti M, 2002, FOOD CHEM, V76, P399, DOI 10.1016/S0308-8146(01)00231-X
   Esturk O, 2014, FOOD BIOPROCESS TECH, V5, P1295
   Girard B, 1998, J AGR FOOD CHEM, V46, P471, DOI 10.1021/jf970646j
   HEINTZ CM, 1983, HORTSCIENCE, V18, P18
   Kader A. A., 2000, HortTechnology, V10, P483
   Kalyoncu IH, 2009, AFR J BIOTECHNOL, V8, P2744
   Kappel F, 2002, HORTSCIENCE, V37, P139
   Karacali I, 2012, EGE U AGR FACULTY PU, V494
   Kelebek H, 2011, INT J FOOD SCI TECH, V46, P2530, DOI 10.1111/j.1365-2621.2011.02777.x
   Kucukbasmaci F, 2008, ACTA HORTIC, P775
   Kupferman G, 2001, ACTA HORTIC, V667, P523
   MCGUIRE RG, 1992, HORTSCIENCE, V27, P1254
   MEHERIUK M, 1995, FOOD RES INT, V28, P239, DOI 10.1016/0963-9969(95)00003-5
   Meheriuk M, 1997, J FOOD QUALITY, V20, P189, DOI 10.1111/j.1745-4557.1997.tb00463.x
   Onursal CE, 2013, J AGR SCI, V6, P91
   Remon S, 2000, J SCI FOOD AGR, V80, P1545, DOI 10.1002/1097-0010(200008)80:10<1545::AID-JSFA680>3.3.CO;2-O
   Serrano M, 2009, J AGR FOOD CHEM, V57, P3240, DOI 10.1021/jf803949k
   Singh P, 2012, FOOD BIOPROCESS TECH, V5, P1028, DOI 10.1007/s11947-010-0447-9
   SWAIN T., 1959, Journal of the Science of Food and Agriculture, V10, P63, DOI 10.1002/jsfa.2740100110
   Thaipong K, 2006, J FOOD COMPOS ANAL, V19, P669, DOI 10.1016/j.jfca.2006.01.003
   Usenik V, 2008, FOOD CHEM, V107, P185, DOI 10.1016/j.foodchem.2007.08.004
   Vinson JA, 2001, J AGR FOOD CHEM, V49, P5315, DOI 10.1021/jf0009293
   Wang Y, 2014, POSTHARVEST BIOL TEC, V92, P62, DOI 10.1016/j.postharvbio.2014.01.003
   Wani A. A., 2014, FOOD PACKAGING SHELF, V1, P86
   Yaman O, 2002, LEBENSM-WISS TECHNOL, V35, P146, DOI 10.1006/fstl.2001.0827
   Yoo KM, 2010, FOOD CHEM, V123, P734, DOI 10.1016/j.foodchem.2010.05.043
NR 34
TC 0
Z9 0
PU UNIV AGR SCI & VETERINARY MED CLUJ-NAPOCA
PI CLUJ-NAPOCA
PA 3-5 MANASTUR ST, CLUJ-NAPOCA, 400372, ROMANIA
SN 0255-965X
J9 NOT BOT HORTI AGROBO
JI Not. Bot. Horti Agrobot. Cluj-Na.
PD JUL-DEC
PY 2014
VL 42
IS 2
BP 501
EP 506
DI 10.1583/nbha4229596
PG 6
WC Plant Sciences
SC Plant Sciences
GA AW5PM
UT WOS:000346326700029
ER

PT J
AU Courgeon, M
   Rautureau, G
   Martin, JC
   Grynszpan, O
AF Courgeon, Matthieu
   Rautureau, Gilles
   Martin, Jean-Claude
   Grynszpan, Ouriel
TI Joint Attention Simulation Using Eye-Tracking and Virtual Humans
SO IEEE TRANSACTIONS ON AFFECTIVE COMPUTING
LA English
DT Article
DE Interaction techniques; virtual reality; evaluation/methodology;
   handicapped persons/special needs
ID AUTISM SPECTRUM DISORDER; SOCIAL COGNITION; GAZE DIRECTION;
   VISUAL-ATTENTION; CHILDREN; PERCEPTION; FIXATION; LOOKING; ADULTS;
   PERFORMANCE
AB This article analyses the issues pertaining to the simulation of joint attention with virtual humans. Gaze represents a powerful communication channel illustrated by the pivotal role of joint attention in social interactions. To our knowledge, there have been only few attempts to simulate gazing patterns associated with joint attention as a mean for developing empathic virtual agents. Eye-tracking technologies now enable creating non-invasive gaze-contingent systems that empower the user with the ability to lead a virtual human's focus of attention in real-time. Although gaze control can be deliberate, most of our visual behaviors in everyday life are not. This article reports empirical data suggesting that users only have partial awareness of controlling gaze-contingent displays. The technical challenges induced by detecting the user's focus of attention in virtual reality are reviewed and several solutions are compared. We designed and tested a platform for creating virtual humans endowed with the ability to follow the user's attention. The article discusses the advantages of simulating joint attention for improving interpersonal skills and user engagement. Joint attention plays a major role in the development of autism. The platform we designed is intended for research and treatment of autism and tests included participants with this disorder.
C1 [Courgeon, Matthieu] Univ Bretagne Sud, Lab STICC, F-29238 Brest 3, France.
   [Rautureau, Gilles] Hop La Pitie Salpetriere, Emot Ctr, CNRS, USR 3246, F-75651 Paris, France.
   [Martin, Jean-Claude] Univ Paris 11, CNRS, LIMSI, F-91403 Orsay, France.
   [Grynszpan, Ouriel] Univ Paris 06, Hop La Pitie Salpetriere, Emot Ctr, CNRS USR 3246, F-75651 Paris, France.
RP Courgeon, M (reprint author), Univ Bretagne Sud, Lab STICC, F-29238 Brest 3, France.
EM courgeon@gmail.com; gilles.rautureau@upmc.fr; martin@limsi.fr;
   ouriel.grynszpan@upmc.fr
FU La Fondation Orange [71/2012]; La Fondation de France et La Fondation
   Adrienne et Pierre Sommer [2007 005874]; L'Agence Nationale de la
   Recherche [ANR 12 SAMA 011 01]
FX The authors wish to thank Rachel Dupuis and Aliye Karasu for
   experimental assistance. We are very grateful to Jacqueline Nadel for
   her advices in experimental design. This work was supported by grants
   from La Fondation Orange (project #71/2012, coordinator: O. Grynszpan),
   La Fondation de France et La Fondation Adrienne et Pierre Sommer
   (project #2007 005874, coordinator: O. Grynszpan) and L'Agence Nationale
   de la Recherche (project #ANR 12 SAMA 011 01, coordinator: P. Fossati).
   The corresponding author is Ouriel Grynszpan (ouriel.grynszpan@upmc.fr).
CR ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   Amini R, 2013, 2013 IEEE INTERNATIONAL CONFERENCE ON HEALTHCARE INFORMATICS (ICHI 2013), P46, DOI 10.1109/ICHI.2013.13
   Bailly G, 2010, SPEECH COMMUN, V52, P598, DOI 10.1016/j.specom.2010.02.015
   BARONCOHEN S, 1995, BRIT J DEV PSYCHOL, V13, P379
   BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
   Bayliss AP, 2006, PSYCHON B REV, V13, P1061, DOI 10.3758/BF03213926
   Bayliss AP, 2006, PSYCHOL SCI, V17, P514, DOI 10.1111/j.1467-9280.2006.01737.x
   Boucher J.-D., 2012, FRONT NEUROROBOTICS, V6, P3
   Bry C, 2011, J EXP SOC PSYCHOL, V47, P987, DOI 10.1016/j.jesp.2011.03.023
   Castelhano MS, 2009, J VISION, V9, DOI 10.1167/9.3.6
   Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
   Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893
   Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
   Courgeon M, 2013, J MULTIMODAL USER IN, V7, P311, DOI 10.1007/s12193-013-0124-1
   Cristinzio C, 2010, BRAIN, V133, P248, DOI 10.1093/brain/awp255
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Doi H, 2009, NEUROPSYCHOLOGIA, V47, P1053, DOI 10.1016/j.neuropsychologia.2008.11.004
   Dratsch T, 2013, J AUTISM DEV DISORD, V43, P286, DOI 10.1007/s10803-012-1569-x
   Driver J, 1999, VIS COGN, V6, P509
   Edlund J., 2013, FRONT NEUROROBOTICS, P185
   Ekman P, 1975, UNMASKING FACE GUIDE
   Emery NJ, 2000, NEUROSCI BIOBEHAV R, V24, P581, DOI 10.1016/S0149-7634(00)00025-7
   Falck-Ytter T, 2013, J AUTISM DEV DISORD, V43, P2249, DOI 10.1007/s10803-013-1776-0
   Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
   Groom V, 2009, INT J HUM-COMPUT ST, V67, P842, DOI 10.1016/j.ijhcs.2009.07.001
   Grynszpan O, 2014, AUTISM, V18, P346, DOI 10.1177/1362361313476767
   Grynszpan O, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00094
   Grynszpan O, 2012, J AUTISM DEV DISORD, V42, P1642, DOI 10.1007/s10803-011-1404-9
   Grynszpan O., 2011, J PHYS THERAPY ED, V25, P42
   HAITH MM, 1977, SCIENCE, V198, P853, DOI 10.1126/science.918670
   Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377
   Henderson JM, 2003, TRENDS COGN SCI, V7, P498, DOI 10.1016/j.tics.2003.09.006
   Hoekstra A, 2007, LECT NOTES COMPUT SC, V4569, P73
   Hood BM, 2003, DEVELOPMENTAL SCI, V6, P67, DOI 10.1111/1467-7687.00256
   Horowitz TS, 2009, Q J EXP PSYCHOL, V62, P2262, DOI 10.1080/17470210902732155
   Hutton SB, 2008, BRAIN COGNITION, V68, P327, DOI 10.1016/j.bandc.2008.08.021
   Jaimes A, 2005, LECT NOTES COMPUT SC, V3766, P1
   Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
   Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kobayashi H, 2001, J HUM EVOL, V40, P419, DOI 10.1006/jhev.2001.0468
   Kopp S, 2010, SPEECH COMMUN, V52, P587, DOI 10.1016/j.specom.2010.02.007
   Krueger J, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00081
   Louwerse MM, 2012, COGNITIVE SCI, V36, P1404, DOI 10.1111/j.1551-6709.2012.01269.x
   Macrae CN, 2002, PSYCHOL SCI, V13, P460, DOI 10.1111/1467-9280.00481
   Manor BR, 2003, J NEUROSCI METH, V128, P85, DOI 10.1016/S0165-0270(03)00151-1
   Manstead A. S. R., 2001, APPRAISAL PROCESSES, P221
   Martinez S., 2010, P 2 INT C CREAT CONT, P7
   MCCONKIE GW, 1975, PERCEPT PSYCHOPHYS, V17, P578, DOI 10.3758/BF03203972
   Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x
   Noris B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044144
   Peters C, 2011, COGN TECHNOL, P293, DOI 10.1007/978-3-642-15184-2_16
   Peters C, 2010, J MULTIMODAL USER IN, V3, P119, DOI 10.1007/s12193-009-0029-1
   Peters C., 2008, INT C MULT INT CHAN
   Peters C, 2010, COMPUT GRAPH-UK, V34, P677, DOI 10.1016/j.cag.2010.09.007
   Peters C., 2003, PERSPECTIVE PSYCHIAT, P1
   POSNER MI, 1980, Q J EXP PSYCHOL, V32, P3, DOI 10.1080/00335558008248231
   Richardson DC, 2007, PSYCHOL SCI, V18, P407, DOI 10.1111/j.1467-9280.2007.01914.x
   Rombough A, 2013, J AUTISM DEV DISORD, V43, P1584, DOI 10.1007/s10803-012-1704-8
   Schilbach L, 2010, J COGNITIVE NEUROSCI, V22, P2702, DOI 10.1162/jocn.2009.21401
   Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001
   Senju A, 2008, BRAIN COGNITION, V67, P127, DOI 10.1016/j.bandc.2007.12.001
   Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x
   Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
   Swanson MR, 2013, J AUTISM DEV DISORD, V43, P707, DOI 10.1007/s10803-012-1616-7
   Tan N., 2011, P 16 INT C INT US IN, P399, DOI 10.1145/1943403.1943475
   vonGrunau M, 1995, PERCEPTION, V24, P1297
   Wang H., 2006, P 2006 S EYE TRACK R, P73, DOI 10.1145/1117309.1117346
   Wilms M, 2010, SOC COGN AFFECT NEUR, V5, P98, DOI 10.1093/scan/nsq024
NR 69
TC 1
Z9 1
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1949-3045
J9 IEEE T AFFECT COMPUT
JI IEEE Trans. Affect. Comput.
PD JUL-SEP
PY 2014
VL 5
IS 3
BP 238
EP 250
DI 10.1109/TAFFC.2014.2335740
PG 13
WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics
SC Computer Science
GA AS9WP
UT WOS:000344589600005
ER

PT J
AU Shopen, R
AF Shopen, Roey
TI The Case for Private Speech As a Mode of Self-Formation What Its Absence
   Contributes to Understanding Autism
SO TOPICS IN LANGUAGE DISORDERS
LA English
DT Article
DE autism; private speech; self
ID THEORY-OF-MIND; SPECTRUM DISORDER; INNER SPEECH; CHILDREN; MEMORY;
   RECOGNITION; ADULTS; ADOLESCENTS; DIFFICULTY; TASK
AB Private speech is common among 3- to 7-year-olds but rare among children with autism spectrum disorders (ASDs). Thus far, this phenomenon has only been studied in narrow cognitive contexts. This article presents a case for why the phenomenon of private speech is essential for the development of self and subjectivity and for why an analysis of private speech from this standpoint will enable a better and broader understanding of difficulties in the experience of self among individuals with ASD. The article discusses the importance of the concept of the self for development and presents evidence of limited concepts of self in autism. Furthermore, it surveys theories on the development of components essential to the development of the self (e.g., self-dialogue, inner speech). Finally, the article lays out a model for how to think about private speech in a broader framework related to individuals with ASD.
C1 Schneider Childrens Hosp, Psychol Med Mental Hlth Clin, IL-645321 Petah Tiqwa, Israel.
RP Shopen, R (reprint author), Schneider Childrens Hosp, Psychol Med Mental Hlth Clin, IL-645321 Petah Tiqwa, Israel.
EM roshpen@gmail.com
CR Accardo CM, 1996, PERCEPT MOTOR SKILL, V82, P559
   Andressen J. J., 1980, J AM PSYCHOANAL ASS, V28, P12
   Anzieu D., 1985, SKIN EGO
   Bakhtin M., 1981, DIALOGIC IMAGINATION, P84
   BARONCOHEN S, 1994, BRIT J PSYCHIAT, V165, P640, DOI 10.1192/bjp.165.5.640
   Bermudez J. L., 1998, BODY SELF
   Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
   BRADLOW PA, 1984, PSYCHOANAL QUART, V53, P267
   Bromberg P., 1998, STANDING SPACES ESSA
   Bruner J., 1989, NARRATIVES CRIB, P73
   Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
   CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
   Dritschel B, 2010, AUTISM, V14, P509, DOI 10.1177/1362361310368407
   Duncan RM, 2001, COGNITIVE DEV, V16, P889
   Dunphy-Lelii S, 2012, RES AUTISM SPECT DIS, V6, P212, DOI 10.1016/j.rasd.2011.05.002
   Farley A, 2010, AUTISM, V14, P519, DOI 10.1177/1362361310368536
   Fonagy P, 2007, J AM PSYCHOANAL ASS, V55, P411
   Frank S., 1975, 1975 ANN M AM PSYCH
   Frawley W, 2008, BEHAV BRAIN SCI, V31, P269, DOI 10.1017/S0140525X08004305
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Furniss F, 2011, AUT CHILD PSYCHO, P437, DOI 10.1007/978-1-4419-8065-6_27
   Gallagher S., 2010, STANFORD ENCY PHILOS
   Gibrau D., 2007, SPAN J PSYCHOL, V10, P41
   Hermans HJM, 2001, CULT PSYCHOL, V7, P243, DOI 10.1177/1354067X0173001
   Hobson RP, 2010, J AUTISM DEV DISORD, V40, P653, DOI 10.1007/s10803-009-0910-5
   Hoff EV, 2005, CREATIVITY RES J, V17, P167, DOI 10.1207/s15326934crj1702&3_4
   Jones PE, 2009, LANG COMMUN, V29, P166, DOI 10.1016/j.langcom.2008.12.003
   Jordan R., 1993, EDUC PSYCHOL, V13, P359, DOI 10.1080/0144341930130312
   Kobayashi M., 2004, THESIS U BRIT COLUMB
   KOHLBERG L, 1968, CHILD DEV, V39, P691
   Kronk C. M., 1994, HLTH CARE IND, V25, P2
   Lakoff G., 1999, PHILOS FLESH EMBODIE
   Larrain A, 2012, THEOR PSYCHOL, V22, P3, DOI 10.1177/0959354311423864
   Lind SE, 2010, J ABNORM PSYCHOL, V119, P896, DOI 10.1037/a0020631
   Lind SE, 2009, J AUTISM DEV DISORD, V39, P1231, DOI 10.1007/s10803-009-0735-2
   Mead G.H., 1934, MIND SELF SOC
   Milord D., 1972, PSYCHOANALYTIC STUDY, V27, P520
   Mitchell S. A., 1993, HOPE DREAD PSYCHOANA, P95
   Modell A. H., 1984, ANNU PSYCHOANAL, V12, P69
   Mohanty J. N., 1970, PHENOMENOLOGY ONTOLO
   Nelson K., 1989, NARRATIVES CRIB
   Nichols S, 2000, COGNITION, V74, P115, DOI 10.1016/S0010-0277(99)00070-0
   Novogrodsky R, 2013, CLIN LINGUIST PHONET, V27, P85, DOI 10.3109/02699206.2012.742567
   OGDEN TH, 1989, INT J PSYCHOANAL, V70, P127
   PRIZANT BM, 1981, J SPEECH HEAR DISORD, V46, P241
   Reddy V, 2010, AUTISM, V14, P531, DOI 10.1177/1362361310370397
   Ricoeur Paul, 1988, TIME NARRATIVE
   Rivard M, 2012, PSYCHOL REC, V62, P165
   Rochat P, 2003, CONSCIOUS COGN, V12, P717, DOI 10.1016/S1053-8100(03)00081-3
   RUBIN KH, 1976, J GENET PSYCHOL, V129, P121
   Rundblad G, 2010, AUTISM, V14, P29, DOI 10.1177/1362361309340667
   SASS LA, 1988, SOC RES, V55, P551
   Southwick JS, 2011, NEUROPSYCHOLOGY, V25, P702, DOI 10.1037/a0024935
   Stern D. N., 2004, PRESENT MOMENT PSYCH
   Teicholz J. G., 1999, KOHUI LOEWALD POSTMO
   Toichi M, 2002, AM J PSYCHIAT, V159, P1422, DOI 10.1176/appi.ajp.159.8.1422
   Tustin F., 1981, AUTISTIC STATES CHIL
   Voloshinov V, 1976, FREUDIANISM MARXIST
   Vygotsky Lev Semyonovitch, 1986, THOUGHT LANGUAGE
   Watson R., 1989, NARRATIVES CRIB, P263
   Wellman HM, 2001, CHILD DEV, V72, P655, DOI 10.1111/1467-8624.00304
   Whitehouse AJO, 2006, J CHILD PSYCHOL PSYC, V47, P857, DOI 10.1111/j.1469-7610.2006.01624.x
   Williams D, 2008, J CHILD PSYCHOL PSYC, V49, P51, DOI 10.1111/j.1469-7610.2007.01836.x
   Williams D, 2010, AUTISM, V14, P474, DOI 10.1177/1362361310366314
   Zahavi D, 2010, AUTISM, V14, P547, DOI 10.1177/1362361310370040
   Zoran R., 2000, 3 VOICE THERAPEUTIC
NR 66
TC 2
Z9 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-8294
EI 1550-3259
J9 TOP LANG DISORD
JI Top. Lang. Disord.
PD JUL-SEP
PY 2014
VL 34
IS 3
BP 240
EP 251
DI 10.1097/TLD.0000000000000023
PG 12
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA AT6CX
UT WOS:000345027700006
ER

PT J
AU Timler, GR
   Boone, WJ
   Bergmann, AA
AF Timler, Geralyn R.
   Boone, William J.
   Bergmann, Amelia A.
TI Development of the Conversation Participation Rating Scale Intervention
   Planning Implications for Two School-Age Children With Autism Spectrum
   Disorders
SO TOPICS IN LANGUAGE DISORDERS
LA English
DT Article
DE autism spectrum disorders; conversation participation; school-age
   children; social (pragmatic) communication disorders; WHO-ICF
ID SPEECH-LANGUAGE PATHOLOGY; HIGH-FUNCTIONING AUTISM; PRAGMATIC LANGUAGE;
   SOCIAL-SKILLS; CONTROLLED-TRIAL; SELF; ADOLESCENTS; PERCEPTIONS;
   QUALITY; ANXIETY
AB Purpose: School-age children with autism spectrum disorders (ASDs) have pervasive challenges in social interactions with peers. This study examined the feasibility of eliciting children's perceptions of their conversation participation with peers for the purposes of assessment and intervention planning. Methods: Two school-age children with ASD completed a newly developed self-report measure, the Conversation Participation Rating Scale (CPRS), designed for children and adolescents between the ages of 7 and 16 years, with social communication and peer interaction difficulties. Descriptive analyses examined agreement and discrepancy among child self-report, parent report, and standardized social language tests. Results: Both children provided a range of responses on the CPRS, revealing participation strengths as well as awareness of specific activity limitations and participation restrictions. Both children scored within the normal range on a social language test, even though parent report measures revealed significant concerns with pragmatic language and social skills. Discussion: The CPRS results contributed unique information to the assessment process. These results provide preliminary support for the feasibility of using a self-report conversation participation measure as a method for obtaining children's unique perspective of social communication activities and challenges in school settings.
C1 [Timler, Geralyn R.; Bergmann, Amelia A.] Miami Univ, Dept Speech Pathol & Audiol, Oxford, OH 45056 USA.
   [Boone, William J.] Miami Univ, Dept Educ Psychol, Oxford, OH 45056 USA.
RP Timler, GR (reprint author), Miami Univ, Dept Speech Pathol & Audiol, 2 Bachelor Hall, Oxford, OH 45056 USA.
EM timlergr@miamioh.edu
CR Adams C, 2002, J CHILD PSYCHOL PSYC, V43, P973, DOI 10.1111/1469-7610.00226
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   American Speech-Language-Hearing Association, 2004, PREF PRACT PATT PROF
   Bauminger N, 2004, J DEV PHYS DISABIL, V16, P193, DOI 10.1023/B:JODD.0000026616.24896.c8
   Baylor C, 2011, AM J SPEECH-LANG PAT, V20, P243, DOI 10.1044/1058-0360(2011/10-0079)
   Baylor C, 2014, J SPEECH LANG HEAR R, V57, P90, DOI 10.1044/1092-4388(2013/12-0414)
   Baylor CR, 2009, J SPEECH LANG HEAR R, V52, P1302, DOI 10.1044/1092-4388(2009/07-0275)
   Bishop D. V., 2006, CHILDRENS COMMUNICAT
   Bond T. G., 2007, APPL RASCH MODEL FUN
   Boone W. J., 2014, RASCH ANAL HUMAN SCI
   Boone WJ, 2006, SCI EDUC, V90, P253, DOI 10.1002/sce.20106
   Bowers L., 2008, SOCIAL LANGUAGE DEV
   Burgess S, 2010, LANG SPEECH HEAR SER, V41, P474, DOI 10.1044/0161-1461(2010/09-0007)
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Crick NR, 2002, CURR DIR PSYCHOL SCI, V11, P98, DOI 10.1111/1467-8721.00177
   Dempsey L, 2010, J COMMUN DISORD, V43, P424, DOI 10.1016/j.jcomdis.2010.05.004
   Dotson WH, 2010, RES AUTISM SPECT DIS, V4, P199, DOI 10.1016/j.rasd.2009.09.005
   Dowell KA, 2008, J CHILD FAM STUD, V17, P291, DOI 10.1007/s10826-007-9137-2
   Eadie TL, 2006, AM J SPEECH-LANG PAT, V15, P307, DOI 10.1044/1058-0360(2006/030)
   Eiser C, 2001, QUAL LIFE RES, V10, P347, DOI 10.1023/A:1012253723272
   Nicpon MF, 2010, J AUTISM DEV DISORD, V40, P1028, DOI 10.1007/s10803-010-0952-8
   Gresham F. M., 2008, SOCIAL SKILLS IMPROV
   Gresham FM, 2011, SCHOOL PSYCHOL QUART, V26, P27, DOI 10.1037/a0022662
   Hewitt L., 2014, SIG 1 PERSPECTIVES L, V21, P5, DOI [10.1044/lle21.1.5, DOI 10.1044/LLE21.1.5]
   Johnson SA, 2009, J AUTISM DEV DISORD, V39, P1706, DOI 10.1007/s10803-009-0809-1
   Kalyva E, 2010, J AUTISM DEV DISORD, V40, P1202, DOI 10.1007/s10803-010-0978-y
   Kasari C, 2012, J CHILD PSYCHOL PSYC, V53, P431, DOI 10.1111/j.1469-7610.2011.02493.x
   Kaufman A. S., 2004, KAUFMAN BRIEF INTELL
   KOLKO DJ, 1993, J CHILD PSYCHOL PSYC, V34, P991, DOI 10.1111/j.1469-7610.1993.tb01103.x
   Li H., 2009, INT J PSYCHOL STUDIE, V1, P2
   Linacre J. M., 2011, WINSTEPS VERSION 3 7
   Norbury CF, 2013, J CHILD PSYCHOL PSYC, V54, P705, DOI 10.1111/jcpp.12110
   Phelps-Terasaki D., 2007, TEST PRAGMATIC LANGU
   Rasch G., 1960, PROBABILISTIC MODELS
   Sainato D., 2008, SOCIAL COMPETENCE YO, P99
   SPENCE SH, 1990, BEHAV ASSESS, V12, P317
   Threats TT, 2008, INT J SPEECH-LANG PA, V10, P50, DOI 10.1080/14417040701768693
   Timler G., 2012, INT M AUT RES TOR ON
   Volden J, 2009, J AUTISM DEV DISORD, V39, P388, DOI 10.1007/s10803-008-0618-y
   Volden J, 2010, AM J SPEECH-LANG PAT, V19, P204, DOI 10.1044/1058-0360(2010/09-0011)
   Washington KN, 2007, INT J SPEECH LANGUAG, V9, P242
   White SW, 2009, J AUTISM DEV DISORD, V39, P1006, DOI 10.1007/s10803-009-0713-8
   Winner M., 2006, INSIDE OUT WHAT MAKE
   World Health Organisation, 2001, INT CLASS FUNCT DIS
   World Health Organization, 2013, US ICF PRACT MAN US
   Wright B. D., 1979, BEST TEST DESIGN
   Wright BD, 1996, RASCH MEASUREMENT T, V9, P468
   Young EC, 2005, LANG SPEECH HEAR SER, V36, P62, DOI 10.1044/0161-1461(2005/006)
NR 48
TC 2
Z9 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-8294
EI 1550-3259
J9 TOP LANG DISORD
JI Top. Lang. Disord.
PD JUL-SEP
PY 2014
VL 34
IS 3
BP 252
EP 267
DI 10.1097/TLD.0000000000000021
PG 16
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA AT6CX
UT WOS:000345027700007
ER

PT J
AU Lotta, LT
   Conrad, K
   Cory-Slechta, D
   Schor, NF
AF Lotta, L. T.
   Conrad, K.
   Cory-Slechta, D.
   Schor, N. F.
TI Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID NERVE GROWTH-FACTOR; INTRACELLULAR DOMAIN; MICE; EXPRESSION; CHILDREN;
   STRESS; DEPENDENCE; APOPTOSIS; NEURONS; SYSTEM
AB The p75 neurotrophin receptor (p75NTR) is normally expressed in cerebellar Purkinje cells throughout the lifespan. Children with autism spectrum behavior exhibit apparent cerebellar Purkinje cell loss. Cerebellar transcriptome changes seen in the murine prenatal valproate exposure model of autism include all of the proteins known to constitute the p75NTR interactome. p75NTR is a modulator of cytoplasmic and mitochondrial redox potential, and others have suggested that aberrant response to oxidant stress has a major role in the pathogenesis of autism. We have created Purkinje cell-selective p75NTR knockout mice that are the progeny of hemizygous Cre-Purkinje cell protein 2 C57Bl mice and p75NTR floxed C57Bl mice. These Cre-loxP mice exhibit complete knockout of p75NTR in similar to 50% of the cerebellar Purkinje cells. Relative to Cre-only mice and wild-type C57Bl mice, this results in a behavioral phenotype characterized by less allogrooming of (P < 0.05; one-way analysis of variance) and socialization or fighting with (each P < 0.05) other mice; less (1.2-fold) non-ambulatory exploration of their environment than wild-type (P < 0.01) or Cre only (P < 0.01) mice; and almost twofold more stereotyped jumping behavior than wild-type (P < 0.05) or Cre (P < 0.02) mice of the same strain. Wild-type mice have more complex dendritic arborization than Cre-loxP mice, with more neurites per unit area (P < 0.025, Student's t-test), more perpendicular branches per unit area (P < 0.025) and more short branches/long neurite (P < 0.0005). Aberrant developmental regulation of expression of p75NTR in cerebellar Purkinje cells may contribute to the pathogenesis of autism.
C1 [Lotta, L. T.; Conrad, K.; Cory-Slechta, D.; Schor, N. F.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA.
RP Schor, NF (reprint author), Univ Rochester, Med Ctr, 601 Elmwood Ave,POB 777, Rochester, NY 14642 USA.
EM Nina_Schor@urmc.rochester.edu
FU William H. Eilinger Endowment of the Golisano Children's Hospital at the
   University of Rochester Medical Center; Strong Children's Research
   Center Pilot Grant; NIH
FX We are grateful to Vesa Kaartinen for providing the p75NTR-floxed
   founder mice for these studies and to Robert H Schor and Simeng Wang for
   assistance with preparation of the figures. We also thank Christopher
   Stodgell for pointing out the relationship between the p75NTR
   interactome and the valproate model transcriptome. These studies were
   funded by the William H. Eilinger Endowment of the Golisano Children's
   Hospital at the University of Rochester Medical Center and by a Strong
   Children's Research Center Pilot Grant. NFS and DC-S have been funded by
   the NIH.
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Arndt TL, 2005, INT J DEV NEUROSCI, V23, P189, DOI 10.1016/j.ijdevneu.2004.11.001
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
   BARKER PA, 1992, MOL CELL BIOCHEM, V110, P1, DOI 10.1007/BF02385000
   Barnes M, 2009, J NEURO-ONCOL, V92, P193, DOI 10.1007/s11060-008-9755-6
   Bogenmann E, 2011, GENESIS, V49, P862, DOI 10.1002/dvg.20747
   Bolduc ME, 2012, CEREBELLUM, V11, P531, DOI 10.1007/s12311-011-0312-z
   Capsoni S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017321
   Carter AR, 2003, MOL CELL NEUROSCI, V22, P1, DOI 10.1016/S1044-7431(02)00015-5
   Ceni C, 2010, J CELL SCI, V123, P2299, DOI 10.1242/jcs.062612
   Chen Y, 2009, J INT MED RES, V37, P281
   Chow ML, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002592
   Cortazzo MH, 1996, J NEUROSCI, V16, P3895
   Dhanoa NK, 2006, EXP NEUROL, V198, P416, DOI 10.1016/j.expneurol.2005.12.022
   Dincel N, 2013, INDIAN J MED RES, V138, P900
   Frade JM, 2005, J NEUROSCI, V25, P1407, DOI 10.1523/JNEUROSCI.3798-04.2005
   Ganeshan V, 2013, CANCER CHEMOTH PHARM, V71, P777, DOI 10.1007/s00280-013-2071-7
   Ghanizadeh A, 2012, CURR MED CHEM, V19, P4000
   Halterman MW, 2010, J BIOL CHEM, V285, P21329, DOI 10.1074/jbc.M109.095299
   Herbert MR, 2006, NEUROTOXICOLOGY, V27, P671, DOI 10.1016/j.neuro.2006.03.017
   Khansari Parto S., 2012, Inflammopharmacology, V20, P103, DOI 10.1007/s10787-012-0124-x
   Korade Z, 2007, NEUROBIOL AGING, V28, P1522, DOI 10.1016/j.neurobiolaging.2006.06.026
   LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
   Mi Z, 2009, J NEUROCHEM, V110, P296
   Mirnics ZK, 2005, NEUROBIOL DIS, V20, P969, DOI 10.1016/j.nbd.2005.06.004
   Nag N, 2009, NEUROSCI LETT, V452, P247, DOI 10.1016/j.neulet.2009.01.006
   O'Halloran CJ, 2011, J CLIN EXP NEUROPSYC, V1, P1
   Rabizadeh S, 2000, J MOL NEUROSCI, V15, P215, DOI 10.1385/JMN:15:3:215
   RAPIN I, 1991, PEDIATRICS, V87, P751
   Reith RM, 2011, NEUROBIOL DIS, V43, P113, DOI 10.1016/j.nbd.2011.02.014
   Schor NF, 2005, PROG NEUROBIOL, V77, P201, DOI 10.1016/j.pneurobio.2005.10.006
   Sheikh AM, 2010, J NEUROSCI RES, V88, P2641, DOI 10.1002/jnr.22416
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Strom SP, 2010, MOL PSYCHIATR, V15, P996, DOI 10.1038/mp.2009.41
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Tyurina YY, 2005, AGING CELL, V4, P187, DOI 10.1111/j1474-9726.2005.00160.x
   Yan CH, 2005, MOL BRAIN RES, V139, P225, DOI 10.1016/j.molbrainres.2005.05.025
   Zagrebelsky M, 2005, J NEUROSCI, V25, P9989, DOI 10.1523/JNEUROSCI.2492-05.2005
NR 38
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUL
PY 2014
VL 4
AR e416
DI 10.1038/tp.2014.55
PG 6
WC Psychiatry
SC Psychiatry
GA AT3HP
UT WOS:000344826700013
PM 25072321
ER

PT J
AU Luke, S
   Vail, CO
   Ayres, KM
AF Luke, Sara
   Vail, Cynthia O.
   Ayres, Kevin M.
TI Using Antecedent Physical Activity to Increase On-Task Behavior in Young
   Children
SO EXCEPTIONAL CHILDREN
LA English
DT Article
ID SELF-STIMULATORY BEHAVIOR; PRESCHOOL-CHILDREN; INAPPROPRIATE BEHAVIORS;
   ACADEMIC-ACHIEVEMENT; EXERCISE; AUTISM; CLASSROOM; COGNITION; RECESS
AB A withdrawal design was used to investigate how physical activity affects on-task behavior of young children with significant developmental delays in a special education preschool classroom. Five preschool age children with significant developmental delays engaged in either physical activity or seated center activities for 20 min prior to a 15-min teacher-directed group activity. Momentary time sampling was used to calculate the percentage of intervals the participants were on-task using 15-s intervals. Results indicated all of the participants' on-task behavior was higher during the physical activity condition. These findings suggest physical activity may be used as a proactive behavioral intervention to improve the on-task behavior of young children with significant developmental delays during teacher-directed group activities.
C1 [Luke, Sara; Vail, Cynthia O.; Ayres, Kevin M.] Univ Georgia, Loganville, GA 30052 USA.
RP Luke, S (reprint author), Univ Georgia, POB 1447, Loganville, GA 30052 USA.
EM slukee@uga.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   BACHMAN JE, 1988, RES DEV DISABIL, V9, P73, DOI 10.1016/0891-4222(88)90021-2
   BACHMAN JE, 1983, J APPL BEHAV ANAL, V16, P477, DOI 10.1901/jaba.1983.16-477
   Brown WH, 2009, J EARLY INTERVENTION, V31, P126, DOI 10.1177/1053815109331858
   BUSHELL D, 1968, J APPL BEHAV ANAL, V1, P55, DOI 10.1901/jaba.1968.1-55
   Carr E. G., 1999, FUNCTIONAL ANAL PROB, P9
   Celiberti DA, 1997, RES DEV DISABIL, V18, P139, DOI 10.1016/S0891-4222(96)00032-7
   Copple C., 2009, DEV APPROPRIATE PRAC, V3<SUP>rd</SUP>
   Duncan GJ, 2007, DEV PSYCHOL, V43, P1428, DOI 10.1037/0012-1649.43.6.1428
   Federal Interagency Forum on Child and Family Statistics, 2007, AM CHILDR KEY NAT IN
   GABLERHALLE D, 1993, RES DEV DISABIL, V14, P359, DOI 10.1016/0891-4222(93)90009-9
   Gast D. L., 2010, SINGLE SUBJECT RES M, P129
   Gast D. L., 2010, SINGLE SUBJECT RES M, P234
   Holmes R. L., 2006, EARLY CHILD DEV CARE, V176, P735, DOI [10.1080/03004430500207179, DOI 10.1080/03004430500207179]
   Horner RH, 2002, J AUTISM DEV DISORD, V32, P423, DOI 10.1023/A:1020593922901
   Howie EK, 2012, J SPORT HEALTH SCI, V1, P160, DOI 10.1016/j.jshs.2012.09.003
   Jarrett OS, 1998, J EDUC RES, V92, P121
   KERN L, 1984, J AUTISM DEV DISORD, V14, P57, DOI 10.1007/BF02408555
   LEBLANC JM, 1982, ANAL INTERVEN DEVEL, V2, P129, DOI 10.1016/0270-4684(82)90014-3
   Mahar MT, 2006, MED SCI SPORT EXER, V38, P2086, DOI 10.1249/01.mss.0000235359.16685.a3
   McClelland MM, 2003, EARLY CHILD RES Q, V18, P206, DOI 10.1016/S0885-2006(03)00026-7
   MCGIMSEY JF, 1988, J AUTISM DEV DISORD, V18, P167, DOI 10.1007/BF02211944
   McKenzie TL, 1997, RES Q EXERCISE SPORT, V68, P195
   Morrissey P. A., 1992, BEHAV RESIDENTIAL TR, V7, P15, DOI [10.1002/bin.2360070505, DOI 10.1002/BIN.2360070505]
   National Association for Sport and Physical Education, 2002, ACT START STAT PHYS
   Nelson C. M., 2000, J POSIT BEHAV INTERV, V2, P131, DOI 10.1177/109830070000200302
   Nicholson H, 2011, PSYCHOL SCHOOLS, V48, P198, DOI 10.1002/pits.20537
   Olstad DL, 2009, APPL PHYSIOL NUTR ME, V34, P551, DOI 10.1139/H09-016
   Pate RR, 2008, J SCHOOL HEALTH, V78, P438, DOI 10.1111/j.1746-1561.2008.00327.x
   Powers S., 1992, BEHAV RESIDENTIAL TR, V7, P15, DOI 10.1002/bin.2360070103
   Reeve C. E., 2000, J POSIT BEHAV INTERV, V2, P144, DOI 10.1177/109830070000200303
   Reilly JJ, 2006, BRIT MED J, V333, P1041, DOI 10.1136/bmj.38979.623773.55
   RosenthalMalek A, 1997, J AUTISM DEV DISORD, V27, P193, DOI 10.1023/A:1025848009248
   Sibley BA, 2003, PEDIATR EXERC SCI, V15, P243
   Binkley T, 2004, BONE, V35, P1383, DOI 10.1016/j.bone.2004.08.012
   Timmons B. W., 2007, APPL PHYSIOL NUTR ME, V32, P122, DOI [10.1139/H07-112, DOI 10.1139/H07-112]
   Tomporowski PD, 2008, EDUC PSYCHOL REV, V20, P111, DOI 10.1007/s10648-007-9057-0
   Tubic T, 2010, HEALTHMED, V4, P750
   WATTERS RG, 1980, J AUTISM DEV DISORD, V10, P379, DOI 10.1007/BF02414814
   Yell M. L., 1988, BEHAVIORAL DISORDERS, V13, P273
NR 40
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0014-4029
EI 2163-5560
J9 EXCEPT CHILDREN
JI Except. Child.
PD JUL
PY 2014
VL 80
IS 4
BP 489
EP 503
DI 10.1177/0014402914527241
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AR9YZ
UT WOS:000343934900008
ER

PT J
AU Cassidy, S
   Bradley, P
   Robinson, J
   Allison, C
   McHugh, M
   Baron-Cohen, S
AF Cassidy, Sarah
   Bradley, Paul
   Robinson, Janine
   Allison, Carrie
   McHugh, Meghan
   Baron-Cohen, Simon
TI Suicidal ideation and suicide plans or attempts in adults with
   Asperger's syndrome attending a specialist diagnostic clinic: a clinical
   cohort study
SO LANCET PSYCHIATRY
LA English
DT Article
ID FUNCTIONING AUTISM; DISORDERS; SPECTRUM; INDIVIDUALS; QUOTIENT; CHILDREN
AB Background Asperger's syndrome in adulthood is frequently associated with depression, but few studies have explored the lifetime experience of self-reported suicidal ideation and suicide plans or attempts in this clinical group. We aimed to assess this prevalence in a clinical cohort of patients in the UK.
   Method In a clinical cohort study, we undertook a retrospective analysis of clinical survey data from adults newly diagnosed with Asperger's syndrome at a specialist diagnostic clinic between Jan 23, 2004, and July 8, 2013, in England. Patients completed a self-report questionnaire before clinical assessment, recording lifetime experience of depression, suicidal ideation, and suicide plans or attempts, along with self-reported measures of autistic traits and empathy. We compared the rate of suicidal ideation in the sample with published rates of suicidal ideation in the general population and other clinical groups. We also assessed associations between depression, autistic traits, empathy, and likelihood of suicidal ideation and suicide plans or attempts.
   Findings 374 adults (256 men and 118 women) were diagnosed with Asperger's syndrome in the study period. 243 (66%) of 367 respondents self-reported suicidal ideation, 127 (35%) of 365 respondents self-reported plans or attempts at suicide, and 116 (31%) of 368 respondents self-reported depression. Adults with Asperger's syndrome were significantly more likely to report lifetime experience of suicidal ideation than were individuals from a general UK population sample (odds ratio 9.6 [95% CI 7.6-11.9], p < 0.0001), people with one, two, or more medical illnesses (p < 0. 0001), or people with psychotic illness (p = 0.019). Compared with people diagnosed with Asperger's syndrome without depression, people with Asperger's syndrome and depression were more likely to report suicidal ideation (p < 0.0001) and suicide plans or attempts (p < 0.0001).
   Interpretation Our findings lend support to anecdotal reports of increased rates of suicidal ideation in adults with Asperger's syndrome, and depression as an important potential risk factor for suicidality in adults with this condition. Because adults with Asperger's syndrome often have many risk factors for secondary depression (eg, social isolation or exclusion, and unemployment), our findings emphasise the need for appropriate service planning and support to reduce risk in this clinical group. Copyright (C) Cassidy et al.
C1 [Cassidy, Sarah; Allison, Carrie; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Bradley, Paul; Robinson, Janine; McHugh, Meghan; Baron-Cohen, Simon] Cambridgeshire & Peterborough NHS Fdn Trust, CLASS Clin, Cambridge, England.
RP Cassidy, S (reprint author), Coventry Univ, Ctr Res Psychol Behav & Achievement, Coventry CV1 5FB, W Midlands, England.
EM sarah.cassidy@coventry.ac.uk
FU Three Guineas Trust; Baily Thomas Foundation; Medical Research Council;
   NIHR-CLAHRC-EoE; Cambridgeshire and Peterborough NHS Foundation Trust
   (CPFT); Autism Research Trust
FX The Three Guineas Trust, the Baily Thomas Foundation, the Medical
   Research Council, NIHR-CLAHRC-EoE, Cambridgeshire and Peterborough NHS
   Foundation Trust (CPFT), and the Autism Research Trust.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Arias AJ, 2008, ADDICT BEHAV, V33, P1199, DOI 10.1016/j.addbeh.2008.05.003
   Balfe Myles, 2010, BMC Res Notes, V3, P300, DOI 10.1186/1756-0500-3-300
   Barnard J, 2001, IGNORED INELIGIBLE R
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S., 2008, AUTISM ASPERGER SYND
   Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   BARRACLO.B, 1974, BRIT J PSYCHIAT, V125, P355, DOI 10.1192/bjp.125.4.355
   Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
   Druss B, 2000, ARCH INTERN MED, V160, P1522, DOI 10.1001/archinte.160.10.1522
   Gillberg C, 2002, GUIDE ASPERGER SYNDR
   Hoekstra A, 2008, J AUTISM DEV DISORD, V38, P1555
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
   Howlin P, 2013, J AM ACAD CHILD PSY, V52, P572, DOI 10.1016/j.jaac.2013.02.017
   Howlin P, 1997, AUTISM, V1, P135, DOI DOI 10.1177/1362361397012003
   Lai C, 2011, PLOS ONE, V6
   Lombardo V, 2007, PLOS ONE, V2, pe883
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P11
   McManus S, 2007, ADULT PSYCHIAT MORBI
   Pilling S, 2012, BRIT MED J, V344, DOI 10.1136/bmj.e4082
   Powell A., 2002, TAKING RESPONSIBILIT
   Radomsky ED, 1999, AM J PSYCHIAT, V156, P1590
   Raja Michele, 2011, Clin Pract Epidemiol Ment Health, V7, P97, DOI 10.2174/1745017901107010097
   Sterling L, 2008, J AUTISM DEV DISORD, V38, P1011, DOI 10.1007/s10803-007-0477-y
   Storch EA, 2013, J AUTISM DEV DISORD, V43, P2450, DOI 10.1007/s10803-013-1795-x
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Woodbury-Smith R, 2005, J AUTISM DEV DISORD, V35, P331
   World Health Organization, 1992, ICD 10 CLASS MENT BE, V1
NR 33
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2215-0374
J9 LANCET PSYCHIAT
JI Lancet Psychiatry
PD JUL
PY 2014
VL 1
IS 2
BP 142
EP 147
DI 10.1016/S2215-0366(14)70248-2
PG 6
WC Psychiatry
SC Psychiatry
GA AR6OP
UT WOS:000343703200026
ER

PT J
AU Reynolds, BM
   Gast, DL
   Luscre, D
AF Reynolds, Brooke M.
   Gast, David L.
   Luscre, Deanna
TI Self-Management of Social Initiations by Kindergarten Students With
   Disabilities in the General Education Classroom
SO JOURNAL OF POSITIVE BEHAVIOR INTERVENTIONS
LA English
DT Article
DE self-management; social initiations; social interactions
ID AUTISM; CHILDREN; INTERVENTION; ADOLESCENTS; BEHAVIOR; PRESCHOOLERS;
   ATTENTION; ASKING; SKILLS
AB The effectiveness of a self-management intervention on social interaction behaviors was evaluated for students with disabilities and social deficits. Four students enrolled in a general education kindergarten classroom were taught to self-monitor social initiations during nonstructured social time via a digital wrist counter. The number of social initiations and concurrent engagement in social interactions were recorded in 10-min observation sessions, within the context of a multiple baseline design across participants. Generalization was assessed in novel social situations through pre- and postintervention sessions. The number of social initiations and mean percentage of intervals participants were interacting increased for all participants. Topics for future research and implications for special education professionals are discussed.
C1 [Reynolds, Brooke M.; Gast, David L.; Luscre, Deanna] Univ Georgia, Athens, GA 30602 USA.
RP Reynolds, BM (reprint author), Univ Georgia, 516 Aderhold Hall, Athens, GA 30602 USA.
EM brookemreynolds@gmail.com
CR Alpern G. D., 2008, DEV PROFILE 3
   Amato-Zech NA, 2006, PSYCHOL SCHOOLS, V43, P211, DOI 10.1002/pits.20137
   Barnhill G. P., 2007, FOCUS AUTISM OTHER D, V22, P116, DOI DOI 10.1177/10883576070220020301
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Bos C. S., 2009, STRATEGIES TEACHING
   Cooper J. O., 2007, APPL BEHAV ANAL
   Davies S, 2000, PSYCHOL SCHOOLS, V37, P135, DOI 10.1002/(SICI)1520-6807(200003)37:2<135::AID-PITS5>3.0.CO;2-U
   Edwards J. S., 1976, B PSYCHONOMIC SOC, V8, P607
   Elliott C., 2007, DIFFERENTIAL ABILITY
   Freeman KA, 2004, BEHAV MODIF, V28, P402, DOI 10.1177/0145445503258982
   Gast D. L., 2010, SINGLE SUBJECT RES M
   Gumpel TP, 2000, PSYCHOL SCHOOLS, V37, P253, DOI 10.1002/(SICI)1520-6807(200005)37:3<253::AID-PITS5>3.0.CO;2-I
   Hallahan D., 2005, LEARNING DISABILITIE
   Harris KR, 2005, J SPEC EDUC, V39, P145, DOI 10.1177/00224669050390030201
   Heath NL, 1996, LEARN DISABILITY Q, V19, P34, DOI 10.2307/1511051
   Jones CD, 2009, J AUTISM DEV DISORD, V39, P432, DOI 10.1007/s10803-008-0642-y
   King-Sears M. E., 2008, PREVENTING SCH FAILU, V52, P25, DOI 10.3200/PSFL.52.4.25-36
   Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P186, DOI 10.2511/rpsd.24.3.186
   Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P174, DOI 10.2511/rpsd.24.3.174
   KOEGEL LK, 1992, J APPL BEHAV ANAL, V25, P341, DOI 10.1901/jaba.1992.25-341
   Koegel RL, 2001, J CLIN CHILD PSYCHOL, V30, P19, DOI 10.1207/S15374424JCCP3001_4
   La Greca AM, 1998, J ABNORM CHILD PSYCH, V26, P83, DOI 10.1023/A:1022684520514
   Lee S. H., 2007, FOCUS AUTISM OTHER D, V22, P2, DOI DOI 10.1177/10883576070220010101
   Licciardello C. C., 2008, ED TREATMENT CHILDRE, V31, P27, DOI DOI 10.1353/ETC.0.0010
   Loftin RL, 2008, J AUTISM DEV DISORD, V38, P1124, DOI 10.1007/s10803-007-0499-5
   LONG JD, 1976, ADOLESCENCE, V11, P29
   Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
   Palmen A, 2008, AUTISM, V12, P83, DOI 10.1177/1362361307085265
   Peterson L., 2006, EDUC TREAT CHILD, V29, P1
   Reinecke DR, 1999, EDUC TRAIN MENT RET, V34, P312
   Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
   Shearer D. D., 1996, EARLY EDUC DEV, V7, P205, DOI 10.1027/s15566935eed0703_1
   STRAIN PS, 1994, J EMOT BEHAV DISORD, V2, P78
   Wechsler D., 2002, WPPSI 3 ADM SCORING
NR 34
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1098-3007
EI 1538-4772
J9 J POSIT BEHAV INTERV
JI J. Posit. Behav. Interv.
PD JUL
PY 2014
VL 16
IS 3
BP 137
EP 148
DI 10.1177/1098300713483176
PG 12
WC Psychology, Clinical; Education, Special
SC Psychology; Education & Educational Research
GA AQ5DB
UT WOS:000342824100003
ER

PT J
AU Axelrod, MI
   Bellini, S
   Markoff, K
AF Axelrod, Michael I.
   Bellini, Scott
   Markoff, Kimberly
TI Video Self-Modeling: A Promising Strategy for Noncompliant Children
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE behavior; noncompliant children; intervention; video self-modeling
ID PEER INTERACTIONS; CLASSROOM-BEHAVIOR; FEEDBACK; STUDENTS;
   INTERVENTIONS; DISORDERS; AUTISM
AB The current study investigated the effects of a Video Self-Modeling (VSM) intervention on the compliance and aggressive behavior of three children placed in a psychiatric hospital. Each participant viewed brief video clips of himself following simple adult instructions just prior to the school's morning session and the unit's afternoon free period. A multiple baseline design across settings was used to evaluate the effects of the VSM intervention on compliance with staff instructions and aggressive behavior on the hospital unit and in the hospital-based classroom. All three participants exhibited higher levels of compliance and fewer aggressive episodes during the intervention condition, and the effects were generally maintained when the intervention was withdrawn. Hospital staff reported at the conclusion of the study that the VSM intervention was easy to implement and beneficial for all participants. Taken altogether, the results suggest VSM is a promising, socially acceptable, and proactive intervention approach for improving the behavior of noncompliant children.
C1 [Axelrod, Michael I.] Univ Wisconsin, Ctr Human Dev, Eau Claire, WI 54702 USA.
   [Axelrod, Michael I.] Univ Wisconsin, Dept Psychol, Eau Claire, WI 54702 USA.
   [Bellini, Scott] Indiana Univ, Sch Psychol, Bloomington, IN 47405 USA.
   [Bellini, Scott] Indiana Univ, Social Skill Res Clin, Bloomington, IN 47405 USA.
   [Markoff, Kimberly] Indiana Univ, Sch Psychol Program, Bloomington, IN 47405 USA.
RP Axelrod, MI (reprint author), Univ Wisconsin, Dept Psychol, HSS 160A, Eau Claire, WI 54702 USA.
EM axelromi@uwec.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baker S. D., 2009, ED TREATMENT CHILDRE, V32, P403, DOI DOI 10.1353/ETC.0.0065
   Bellini S, 2007, EXCEPT CHILDREN, V73, P264
   Booth S. R., 1983, BEHAV DISORDERS, V9, P55
   Clare SK, 2000, PSYCHOL SCHOOLS, V37, P517, DOI 10.1002/1520-6807(200011)37:6<517::AID-PITS4>3.0.CO;2-Y
   Davis R. A., 1979, SCH PSYCHOL REV, V8, P128
   Dowrick PW, 1999, APPL PREV PSYCHOL, V8, P23, DOI 10.1016/S0962-1849(99)80009-2
   Dowrick PW, 2012, WIRES COGN SCI, V3, P215, DOI 10.1002/wcs.1156
   Elliott S. N., 1988, HDB BEHAV THERAPY ED, P121
   Embregts P. J., 2002, INT J DISABIL DEV ED, V49, P105, DOI 10.1080/10349120120115361
   Embregts PJCM, 2000, RES DEV DISABIL, V21, P409, DOI 10.1016/S0891-4222(00)00052-4
   ESVELDT KC, 1974, J EDUC RES, V67, P453
   Falk GD, 1996, BEHAV DISORDERS, V21, P261
   KEHLE TJ, 1986, SCHOOL PSYCHOL REV, V15, P289
   Kehle TJ, 2002, PSYCHOL SCHOOLS, V39, P203, DOI 10.1002/pits.10031
   KERN L, 1995, J APPL BEHAV ANAL, V28, P47, DOI 10.1901/jaba.1995.28-47
   KERNDUNLAP L, 1992, J APPL BEHAV ANAL, V25, P355, DOI 10.1901/jaba.1992.25-355
   LONNECKER C, 1994, BEHAV DISORDERS, V20, P24
   National Autism Center, 2009, NAT STAND REP
   Nikopoulos CK, 2004, J APPL BEHAV ANAL, V37, P93, DOI 10.1901/jaba.2004.37-93
   O'Reilly M., 2005, ED PSYCHOL, V25, P199, DOI DOI 10.1080/0144341042000301157
   Osborne S. S., 1986, BEHAV DISORDERS, V12, P60
   Walther M., 1991, ED TREATMENT CHILDRE, V14, P53
   WELLS KC, 1980, J CLIN CHILD PSYCHOL, V9, P217
   WOLTERSDORF MA, 1992, CHILD FAM BEHAV THER, V14, P53, DOI 10.1300/J019v14n02_04
NR 25
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD JUL
PY 2014
VL 38
IS 4
BP 567
EP 586
DI 10.1177/0145445514521232
PG 20
WC Psychology, Clinical
SC Psychology
GA AQ3HB
UT WOS:000342681000006
ER

PT J
AU Bronson, SL
   Bale, TL
AF Bronson, Stefanie L.
   Bale, Tracy L.
TI Prenatal Stress-Induced Increases in Placental Inflammation and
   Offspring Hyperactivity Are Male-Specific and Ameliorated by Maternal
   Antiinflammatory Treatment
SO ENDOCRINOLOGY
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; IMMUNE ACTIVATION; BRAIN-DEVELOPMENT;
   NUCLEUS-ACCUMBENS; DOPAMINERGIC SYSTEM; PREFRONTAL CORTEX;
   SEXUAL-DIMORPHISM; RECEPTOR-BINDING; GENE-EXPRESSION; FETAL-BRAIN
AB Adverse experiences during gestation such as maternal stress and infection are known risk factors for neurodevelopmental disorders, including schizophrenia, autism, and attention deficit/hyperactivity disorder. The mechanisms by which these distinct exposures may confer similar psychiatric vulnerability remain unclear, although likely involve pathways common to both stress and immune responses at the maternal-fetal interface. We hypothesized that maternal stress-induced activation of immune pathways within the placenta, the sex-specific maternal-fetal intermediary, may contribute to prenatal stress programming effects on the offspring. Therefore, we assessed for markers indicative of stress-induced placental inflammation, and examined the ability of maternal nonsteroidal antiinflammatory drug (NSAID) treatment to ameliorate placental effects and thereby rescue the stress-dysregulation phenotype observed in our established mouse model of early prenatal stress (EPS). As expected, placental gene expression analyses revealed increased levels of immune response genes, including the proinflammatory cytokines IL-6 and IL-1 beta, specifically in male placentas. NSAID treatment partially ameliorated these EPS effects. Similarly, in adult offspring, males displayed stress-induced locomotor hyperactivity, a hallmark of dopaminergic dysregulation, which was ameliorated by maternal NSAID treatment. Fitting with these outcomes and supportive of dopamine pathway involvement, expression of dopamine D1 and D2 receptors was altered by EPS in males. These studies support an important interaction between maternal stress and a proinflammatory state in the long-term programming effects of maternal stress.
C1 [Bronson, Stefanie L.; Bale, Tracy L.] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
RP Bale, TL (reprint author), Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
EM tbale@vet.upenn.edu
FU National Institutes of Health [MH087597, MH091258]
FX This work was supported by National Institutes of Health Grants MH087597
   and MH091258.
CR Amateau SK, 2004, NAT NEUROSCI, V7, P643, DOI 10.1038/nn1254
   ARCK PC, 1995, BIOL REPROD, V53, P814, DOI 10.1095/biolreprod53.4.814
   Arck PC, 2001, AM J REPROD IMMUNOL, V46, P117, DOI 10.1111/j.8755-8920.2001.460201.x
   Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
   Baharnoori M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054439
   Baier CJ, 2012, NEUROTOX RES, V22, P16, DOI 10.1007/s12640-011-9305-4
   Bilbo SD, 2012, FRONT NEUROENDOCRIN, V33, P267, DOI 10.1016/j.yfrne.2012.08.006
   Bitanihirwe BKY, 2010, NEUROPSYCHOPHARMACOL, V35, P2462, DOI 10.1038/npp.2010.129
   Blois SM, 2004, J IMMUNOL, V172, P5893
   Bloom B, 2010, VITAL HLTH STAT, V10, P1
   Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
   Bowman RE, 2004, ENDOCRINOLOGY, V145, P3778, DOI 10.1210/en.2003-1759
   Bronson SL, 2011, HANDBOOK OF SCHIZOPHRENIA SPECTRUM DISORDERS, VOL 1, P263, DOI 10.1007/978-94-007-0837-2_12
   Brown AS, 2012, DEV NEUROBIOL, V72, P1272, DOI 10.1002/dneu.22024
   Brummelte S, 2012, NEUROPHARMACOLOGY, V62, P406, DOI 10.1016/j.neuropharm.2011.08.017
   Butts CL, 2008, CELL IMMUNOL, V252, P7, DOI 10.1016/j.cellimm.2007.09.009
   Canales JJ, 2000, PHARMACOL BIOCHEM BE, V67, P161, DOI 10.1016/S0091-3057(00)00311-7
   Clapcote SJ, 2005, BIOTECHNIQUES, V38, P702, DOI 10.2144/05385BM05
   Clifton VL, 2010, PLACENTA, V31, pS33, DOI 10.1016/j.placenta.2009.11.010
   Coussons-Read ME, 2007, BRAIN BEHAV IMMUN, V21, P343, DOI 10.1016/j.bbi.2006.08.006
   Coussons-Read ME, 2005, PSYCHOSOM MED, V67, P625, DOI 10.1097/01.psy.0000170331.74960.ad
   CRAWLEY JN, 1981, PHARMACOL BIOCHEM BE, V15, P695, DOI 10.1016/0091-3057(81)90007-1
   Cvitic S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079233
   Ejima K, 2000, BIOL REPROD, V62, P178, DOI 10.1095/biolreprod62.1.178
   Fineberg AM, 2013, BIOL PSYCHIAT, V73, P951, DOI 10.1016/j.biopsych.2013.01.001
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Froehlich TE, 2007, ARCH PEDIAT ADOL MED, V161, P857, DOI 10.1001/archpedi.161.9.857
   Gabory A, 2013, BIOL SEX DIFFER, V4, DOI 10.1186/2042-6410-4-5
   Gerber AR, 2012, ENDOCRINOLOGY, V153, P4830, DOI 10.1210/en.2012-1601
   Gesundheit B, 2013, J AUTOIMMUN, V44, P1, DOI 10.1016/j.jaut.2013.05.005
   Geyer MA, 2003, CURR PROTOC NEUROSCI
   Gilmore JH, 2005, J NEUROIMMUNOL, V159, P106, DOI 10.1016/j.jneuroim.2004.10.008
   Goel N, 2010, ENDOCRINOLOGY, V151, P1784, DOI 10.1210/en.2009-1180
   Golan H, 2006, NEUROSCIENCE, V141, P1909, DOI 10.1016/j.neuroscience.2006.05.045
   Gruen RJ, 1996, EUR J PHARMACOL, V309, P115, DOI 10.1016/0014-2999(96)00332-9
   Guller S, 1999, SEMIN REPROD ENDOCR, V17, P39, DOI 10.1055/s-2007-1016210
   Harris LK, 2006, AM J PATHOL, V169, P1863, DOI 10.2353/ajpath.2006.060265
   Hauguel-de Mouzon S, 2006, PLACENTA, V27, P794, DOI 10.1016/j.placenta.2005.08.009
   Holloway T, 2013, J NEUROSCI, V33, P1088, DOI 10.1523/JNEUROSCI.2331-12.2013
   HOOKS MS, 1995, NEUROSCIENCE, V64, P587, DOI 10.1016/0306-4522(94)00409-X
   Howerton CL, 2012, HORM BEHAV, V62, P237, DOI 10.1016/j.yhbeh.2012.03.007
   Howerton CL, 2013, P NATL ACAD SCI USA, V110, P5169, DOI 10.1073/pnas.1300065110
   Hsiao EY, 2012, DEV NEUROBIOL, V72, P1317, DOI 10.1002/dneu.22045
   Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
   Huizink AC, 2004, PSYCHOL BULL, V130, P115, DOI 10.1037/0033-2909.130.1.115
   James AH, 2008, OBSTET GYNECOL SURV, V63, P49
   Jansson T, 2007, CLIN SCI, V113, P1, DOI 10.1042/CS20060339
   Kapoor A, 2005, J PHYSIOL-LONDON, V566, P967, DOI 10.1113/jphysiol.2005.090191
   Kapoor A, 2009, BEHAV BRAIN RES, V197, P144, DOI 10.1016/j.bbr.2008.08.018
   Khashan AS, 2008, ARCH GEN PSYCHIAT, V65, P146, DOI 10.1001/archgenpsychiatry.2007.20
   Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
   Koenig JI, 2002, NEUROPSYCHOPHARMACOL, V27, P309
   Li JO, 2010, EUR CHILD ADOLES PSY, V19, P747, DOI 10.1007/s00787-010-0113-9
   Mao J, 2010, P NATL ACAD SCI USA, V107, P5557, DOI 10.1073/pnas.1000440107
   Markham JA, 2013, J COMP NEUROL, V521, P1828, DOI 10.1002/cne.23262
   Markham JA, 2010, FRONT BEHAV NEUROSCI, V4, DOI 10.3389/fnbeh.2010.00173
   Markham JA, 2011, PSYCHOPHARMACOLOGY, V214, P89, DOI 10.1007/s00213-010-2035-0
   Martinez-Tellez RI, 2009, SYNAPSE, V63, P794, DOI 10.1002/syn.20664
   Matrisciano F, 2013, NEUROPHARMACOLOGY, V68, P184, DOI 10.1016/j.neuropharm.2012.04.013
   McEuen JG, 2009, ENDOCRINOLOGY, V150, P3709, DOI 10.1210/en.2008-1721
   Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
   Morgan CP, 2011, J NEUROSCI, V31, P11748, DOI 10.1523/JNEUROSCI.1887-11.2011
   Mueller BR, 2007, PHYSIOL BEHAV, V91, P55, DOI 10.1016/j.physbeh.2007.01.017
   Mueller BR, 2008, J NEUROSCI, V28, P9055, DOI 10.1523/JNEUROSCI.1424-08.2008
   Mueller BR, 2006, PHYSIOL BEHAV, V88, P605, DOI 10.1016/j.physbeh.2006.05.019
   Muhammad A, 2012, NEUROSCIENCE, V216, P103, DOI 10.1016/j.neuroscience.2012.04.041
   Muralimanoharan S, 2013, PLACENTA, V34, P1183, DOI 10.1016/j.placenta.2013.09.015
   Myatt L, 2006, J PHYSIOL-LONDON, V572, P25, DOI 10.1113/jphysiol.2006.104968
   Najjar S, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-142
   O'Shaughnessy PJ, 2006, INT J ANDROL, V29, P90, DOI 10.1111/j.1365-2605.2005.00555.x
   Owen D, 2007, J PHYSIOL-LONDON, V578, P249, DOI 10.1113/jphysiol.2006.122887
   Palmer AA, 2008, BRAIN RES, V1237, P62, DOI 10.1016/j.brainres.2008.07.089
   Parker VJ, 2010, J REPROD IMMUNOL, V85, P86, DOI 10.1016/j.jri.2009.10.011
   Paxinos G, 2001, MOUSE BRAIN STEREOTA
   Rodgers AB, 2013, J NEUROSCI, V33, P9003, DOI 10.1523/JNEUROSCI.0914-13.2013
   Ronald A., 2011, FRONT PSYCHOL, V1, P223
   Rossant J, 2001, NAT REV GENET, V2, P538, DOI 10.1038/35080570
   Ryan BC, 2002, NEUROSCI BIOBEHAV R, V26, P665, DOI 10.1016/S0149-7634(02)00038-6
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
   Son GH, 2007, BIOCHEM BIOPH RES CO, V352, P823, DOI 10.1016/j.bbrc.2006.11.104
   Sood R, 2006, P NATL ACAD SCI USA, V103, P5478, DOI 10.1073/pnas.0508035103
   Stark MJ, 2009, AM J PHYSIOL-REG I, V297, pR510, DOI 10.1152/ajpregu.00175.2009
   Stohr T, 1998, PHARMACOL BIOCHEM BE, V59, P799, DOI 10.1016/S0091-3057(97)00541-8
   Teegarden SL, 2007, BIOL PSYCHIAT, V61, P1021, DOI 10.1016/j.biopsych.2006.09.032
   Urakubo A, 2001, SCHIZOPHR RES, V47, P27, DOI 10.1016/S0920-9964(00)00032-3
   Vane JR, 2003, THROMB RES, V110, P255, DOI 10.1016/S0049-3848(03)00379-7
   van Os J, 1998, BRIT J PSYCHIAT, V172, P324, DOI 10.1192/bjp.172.4.324
   Vuillermot S, 2010, J NEUROSCI, V30, P1270, DOI 10.1523/JNEUROSCI.5408-09.2010
   Watson JB, 1999, DEV PSYCHOPATHOL, V11, P457, DOI 10.1017/S0954579499002151
   Weinstock M, 2008, NEUROSCI BIOBEHAV R, V32, P1073, DOI 10.1016/j.neubiorev.2008.03.002
   Weinstock M, 2011, STRESS, V14, P604, DOI 10.3109/10253890.2011.588294
   Weinstock M, 2007, NEUROCHEM RES, V32, P1730, DOI 10.1007/s11064-007-9339-4
   WELLER A, 1988, PHYSIOL BEHAV, V43, P139, DOI 10.1016/0031-9384(88)90229-6
   Wilson CA, 2013, BEHAV BRAIN RES, V238, P279, DOI 10.1016/j.bbr.2012.10.003
   Yeganegi M, 2009, AM J OBSTET GYNECOL, V200, P532
   ZHOU DH, 1993, ENDOCRINOLOGY, V133, P2523, DOI 10.1210/en.133.6.2523
NR 97
TC 6
Z9 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUL
PY 2014
VL 155
IS 7
BP 2635
EP 2646
DI 10.1210/en.2014-1040
PG 12
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AP8QI
UT WOS:000342343400030
PM 24797632
ER

PT J
AU Chi, DL
AF Chi, Donald L.
TI Caregivers Who Refuse Preventive Care for Their Children: The
   Relationship Between Immunization and Topical Fluoride Refusal
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID COMMUNITY WATER FLUORIDATION; PERSONAL-BELIEF EXEMPTIONS; AUTISM
   SPECTRUM DISORDERS; HEALTH SUPERVISION VISITS; LOW-INCOME CHILDREN;
   CHILDHOOD IMMUNIZATION; ELEMENTARY-SCHOOL; DECISION-MAKING;
   UNITED-STATES; ORAL-HEALTH
AB Objectives. The aim of this study was to examine caregivers' refusal of preventive medical and dental care for children.
   Methods. Prevalence rates of topical fluoride refusal based on dental records and caregiver self-reports were estimated for children treated in 3 dental clinics in Washington State. A 60-item survey was administered to 1024 caregivers to evaluate the association between immunization and topical fluoride refusal. Modified Poisson regression models were used to estimate prevalence rate ratios (PRRs).
   Results. The prevalence of topical fluoride refusal was 4.9% according to dental records and 12.7% according to caregiver self-reports. The rate of immunization refusal was 27.4%. In the regression models, immunization refusalwas significantly associated with topical fluoride refusal (dental record PRR = 1.61; 95% confidence interval [CI] = 1.32, 1.96; P < .001; caregiver self-report PRR = 6.20; 95% CI = 3.21, 11.98; P < .001). Caregivers younger than 35 years were significantly more likely than older caregivers to refuse both immunizations and topical fluoride (P < .05).
   Conclusions. Caregiver refusal of immunizations is associated with topical fluoride refusal. Future research should identify the behavioral and social factors related to caregiver refusal of preventive care with the goal of developing multidisciplinary strategies to help caregivers make optimal preventive care decisions for children.
C1 Univ Washington, Sch Dent, Dept Oral Hlth Sci, Seattle, WA 98195 USA.
RP Chi, DL (reprint author), Univ Washington, Sch Dent, Dept Oral Hlth Sci, Box 357475, Seattle, WA 98195 USA.
EM dchi@uw.edu
FU National Institute of Dental and Craniofacial Research of the National
   Institutes of Health [K08DE020856, L60MD003921, R03DE021439,
   U54DE019346]; University of Washington Institute for Translational
   Health Sciences [UL1RR025014]; William T. Grant Foundation Scholars
   Program
FX This study was supported by the National Institute of Dental and
   Craniofacial Research of the National Institutes of Health (grants
   K08DE020856, L60MD003921, R03DE021439, and U54DE019346), the University
   of Washington Institute for Translational Health Sciences (grant
   UL1RR025014), and the William T. Grant Foundation Scholars Program.
CR Adams SH, 2012, J PUBLIC HEALTH DENT, V72, P252, DOI 10.1111/j.1752-7325.2012.00332.x
   American Dental Association, 2005, CURRENT DENTAL TERMI
   Armfield JM, 2011, COMMUNITY DENT HLTH, V28, P40, DOI 10.1922/CDH_2534Armfield07
   Atwell JE, 2013, PEDIATRICS, V132, P624, DOI 10.1542/peds.2013-0878
   Bassin EB, 2006, CANCER CAUSE CONTROL, V17, P421, DOI 10.1007/s10552-005-0500-6
   Bazzano A, 2012, AJIDD-AM J INTELLECT, V117, P233, DOI 10.1352/1944-7558-117.3.233
   Beltran-Aguilar ED, PREVALENCE AND SEVER
   Berger BE, 2010, HUM VACCINES, V6, P1016, DOI 10.4161/hv.6.12.13398
   Blendell RL, 2012, J PERINAT NEONAT NUR, V26, P230, DOI 10.1097/JPN.0b013e3182611b7b
   Blum John D, 2006, Med Law, V25, P273
   Caplan AL, 2012, J LAW MED ETHICS, V40, P606, DOI 10.1111/j.1748-720X.2012.00693.x
   Capozza LE, 2012, PEDIATR DENT, V34, P480
   Centers for Disease Control and Prevention, 1974, MMWR-MORBID MORTAL W, V23, P199
   Chi DL, 2010, J PUBLIC HEALTH DENT, V70, P35, DOI 10.1111/j.1752-7325.2009.00141.x
   Chi DL, 2013, AM J PUBLIC HEALTH, V103, P347, DOI 10.2105/AJPH.2012.300899
   Choi AL, 2012, ENVIRON HEALTH PERSP, V120, P1362, DOI 10.1289/ehp.1104912
   Diekema DS, 2013, HUM VACC IMMUNOTHER, V9, P2661, DOI 10.4161/hv.26284
   EASLEY MW, 1990, PUBLIC HEALTH REP, V105, P348
   Fair E, 2002, PEDIATRICS, V109, DOI 10.1542/peds.109.1.e2
   Filstrup Sara L, 2003, Pediatr Dent, V25, P431
   Fiset L, 2000, J AM DENT ASSOC, V131, P961
   Flaherty DK, 2011, ANN PHARMACOTHER, V45, P1302, DOI 10.1345/aph.1Q318
   Fredrickson DD, 2004, FAM MED, V36, P431
   Freed GL, 2004, AM J PREV MED, V26, P11, DOI 10.1016/j.amepre.2003.09.004
   Gaudino JA, 2012, VACCINE, V30, P1132, DOI 10.1016/j.vaccine.2011.12.006
   GESSNER BD, 1994, NEW ENGL J MED, V330, P95, DOI 10.1056/NEJM199401133300203
   Gilmour J, 2011, PEDIATRICS, V128, pS167, DOI 10.1542/peds.2010-2720E
   Glanz JM, 2013, ACAD PEDIATR, V13, P481, DOI 10.1016/j.acap.2013.05.030
   Glanz JM, 2009, PEDIATRICS, V123, P1446, DOI 10.1542/peds.2008-2150
   Glanz JM, 2010, ARCH PEDIAT ADOL MED, V164, P66, DOI 10.1001/archpediatrics.2009.244
   Glied S, 2008, THE ECONOMIC VALUE O
   Gorin SS, 2006, ANN BEHAV MED, V32, P179, DOI 10.1207/s15324796abm3203_3
   Gowda C, 2013, HUM VACC IMMUNOTHER, V9, P22821
   Griffin SO, 2002, COMMUNITY DENT ORAL, V30, P199, DOI 10.1034/j.1600-0528.2002.300306.x
   Gust DA, 2008, PEDIATRICS, V122, P718, DOI 10.1542/peds.2007-0538
   Hellwig E, 2004, CARIES RES, V38, P258, DOI 10.1159/000077764
   HOFFMAN R, 1980, PEDIATRICS, V65, P897
   Humphris GM, 2013, INT J PAEDIATR DENT
   Hyde S, 2006, J DENT RES, V85, P79
   IBM Corp, 2010, IBM SPSS STATISTICS
   Imdad A, 2013, PEDIATRICS, V132, P37, DOI 10.1542/peds.2012-3449
   Institute of Medicine, 2011, ADVERSE EFFECTS OF V
   Institute of Medicine, 2013, CHILDHOOD IMMUNIZATI
   Jackson SL, 2011, AM J PUBLIC HEALTH, V101, P1900, DOI 10.2105/AJPH.2010.200915
   Kennedy AM, 2005, PUBLIC HEALTH REP, V120, P252
   Kim FM, 2011, J DENT RES, V90, P1171, DOI 10.1177/0022034511418828
   Kramer M H, 1996, MMWR CDC Surveill Summ, V45, P1
   Lantos JD, 2012, J HEALTH POLIT POLIC, V37, P131, DOI 10.1215/03616878-1496038
   Lawrence Glenda L, 2004, Aust Fam Physician, V33, P568
   Lawrence MA, 2009, NUTR REV, V67, pS73, DOI 10.1111/j.1753-4887.2009.00164.x
   Leask J, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-154
   LELAND DE, 1980, J AM WATER WORKS ASS, V72, P238
   Luthy KE, 2010, PUBLIC HEALTH NURS, V27, P25, DOI 10.1111/j.1525-1446.2009.00823.x
   Ma CT, 2008, AMBUL PEDIATR, V8, P50, DOI 10.1016/j.ambp.2007.08.004
   Maayan-Metzger A, 2013, ACTA PAEDIATR
   Marcenes W, 2013, J DENT RES, V92, P592, DOI 10.1177/0022034513490168
   Marinho VC, 2003, COCHRANE DB SYST REV, V4, DOI DOI 10.1002/14651858.CD002782
   May T, 2005, BIOETHICS, V19, P407, DOI 10.1111/j.1467-8519.2005.00452.x
   McCauley MM, 2012, ACAD PEDIATR, V12, P375, DOI 10.1016/j.acap.2012.06.007
   McMahon BJ, 2009, J INFECT DIS, V200, P1390, DOI 10.1086/606119
   Middleman AB, 2004, J ADOLESCENT HEALTH, V34, P414, DOI 10.1016/j.jadohealth.2003.08.009
   Milgrom P, 1998, MED CARE, V36, P554, DOI 10.1097/00005650-199804000-00011
   Neenan M E, 1996, Community Dent Health, V13 Suppl 2, P10
   Omer SB, 2009, NEW ENGL J MED, V360, P1981
   Opel DJ, 2013, PEDIATRICS, V132, P1037, DOI 10.1542/peds.2013-2037
   Opel DJ, 2009, ARCH PEDIAT ADOL MED, V163, P432, DOI 10.1001/archpediatrics.2009.42
   Opel DJ, 2012, VACCINE, V30, P1269, DOI 10.1016/j.vaccine.2011.12.129
   Pahel BT, 2011, PEDIATRICS, V127, pE682, DOI 10.1542/peds.2010-1457
   Penman AD, 1997, PUBLIC HEALTH REP, V112, P403
   PETERSEN LR, 1988, AM J PUBLIC HEALTH, V78, P711, DOI 10.2105/AJPH.78.6.711
   Piccoli NB, 2012, FOOD NUTR BULL, V33, pS360
   Pratt ET, 2002, J LAW MED ETHICS, V30, P117
   PROCHASKA JO, 1994, HEALTH PSYCHOL, V13, P39, DOI 10.1037/0278-6133.13.1.39
   Quadri-Sheriff M, 2012, PEDIATRICS, V130, P522, DOI 10.1542/peds.2012-0140
   Quinonez CR, 2009, CAN J PUBLIC HEALTH, V100, P96
   Raczniak GA, 2013, J INFECT DIS, V207, P493, DOI 10.1093/infdis/jis710
   Rada RE, 2010, J AM DENT ASSOC, V141, P947
   Radandt NE, 2013, J DENT RES, V92, P3198
   Robison SG, 2012, PEDIATRICS, V130, P32, DOI 10.1542/peds.2011-3154
   Rozier RG, 1999, J PUBLIC HEALTH DENT, V59, P239, DOI 10.1111/j.1752-7325.1999.tb03276.x
   Rozier R Gary, 2010, J Am Dent Assoc, V141, P1480
   Salmon DA, 2005, ARCH PEDIAT ADOL MED, V159, P470, DOI 10.1001/archpedi.159.5.470
   Salmon Daniel A, 2006, Emerg Themes Epidemiol, V3, P13, DOI 10.1186/1742-7622-3-13
   Salmon Daniel A, 2009, WMJ, V108, P17
   Sheiham A, 2000, COMMUNITY DENT ORAL, V28, P399, DOI 10.1034/j.1600-0528.2000.028006399.x
   Shim E, 2012, J THEOR BIOL, V295, P194, DOI 10.1016/j.jtbi.2011.11.005
   Sidhu KS, 2002, J ENVIRON HEALTH, V65, P16
   Sidhu KS, 2002, J ENV HLTH, V65, P38
   Singleton RJ, 2014, PEDIATR INFECT DIS J, V33, P276, DOI 10.1097/INF.0000000000000100
   Smith PJ, 2011, PUBLIC HEALTH REP, V126, P135
   State and county QuickFacts, STATE AND COUNTY QUI
   Thompson JW, 2007, AM J PREV MED, V32, P194, DOI 10.1016/j.amepre.2006.10.014
   U.S. Department of Health and Human Services, HEALTHY PEOPLE 2020
   VOGT RL, 1982, AM J PUBLIC HEALTH, V72, P1168, DOI 10.2105/AJPH.72.10.1168
   Wei FF, 2009, BMC PEDIATR, V9, DOI 10.1186/1471-2431-9-18
   Wells KB, 2012, VACCINE, V30, P5901, DOI 10.1016/j.vaccine.2012.07.047
   Whyte MD, 2011, J COMMUN HEALTH NURS, V28, P204, DOI 10.1080/07370016.2011.615178
   Wong MCM, 2010, COCHRANE DB SYST REV, V1
   Zou GY, 2013, STAT METHODS MED RES, V22, P661, DOI 10.1177/0962280211427759
NR 99
TC 1
Z9 1
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD JUL
PY 2014
VL 104
IS 7
BP 1327
EP 1333
DI 10.2105/AJPH.2014.301927
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AP1EM
UT WOS:000341809500051
PM 24832428
ER

PT J
AU Williams, KE
   Hendy, HM
AF Williams, Keith E.
   Hendy, Helen M.
TI Variables Associated With the Use of Complete Oral Calorie Supplements
   in Children With Feeding Problems
SO JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
LA English
DT Article
DE supplements; child; developmental disability; feeding problems;
   underweight; overweight; parent; meal
ID MEALTIME ACTION SCALE; DISABILITIES; BEHAVIOR
AB Objective: To examine child and parent variables associated with complete oral calorie supplement use among children with feeding problems.
   Design: Correlational examination of data from patient intake surveys.
   Setting: Hospital-based feeding program.
   Participants: Participants included 281 parents of children referred to a hospital-based feeding clinic, including 114 who received supplements (70.2% boys; mean age, 60.1 months) and 167 who did not receive (79.6% boys; mean age, 67.5 months).
   Variables Measured: Children's age, gender, weight status, diagnostic category (no special needs, autism, or other special needs), supplement intake, oral motor problems, child mealtime behavior (using the Child Eating Behavior Questionnaire), parent feeding practices (using the Parent Mealtime Action Scale), and diet variety for child and parent.
   Analysis: Chi-square analyses compared children who did and did not receive supplements for their percentage of gender, diagnostic, and weight status categories; t tests or Mann-Whitney U tests compared children who did and did not receive supplements, for age, oral motor problems, children's mealtime behavior, parent feeding practices, and diet variety.
   Results: Compared with children who did not receive nutritional supplements, those who did were younger (P < .01) and more underweight (P < .001), and showed less Food Responsiveness (P < .001), less Food Enjoyment (P < .001), more Food Satiety (P < .001, and more Slow Eating (P < .001), and their parents were more likely to use Insistence on Eating (P < .001).
   Conclusions: Whereas supplement use was related to underweight, 78.2% of children receiving them were normal weight or overweight, which suggests that supplements are being used to address mealtime selective eating. The use of supplements should be considered carefully because they do not appear to increase diet variety and may increase the chance of overweight over time.
C1 [Williams, Keith E.] Penn State Hershey Med Ctr, Feeding Program, Hershey, PA 17033 USA.
   [Hendy, Helen M.] Penn State Univ, Psychol Program, Schuylkill Haven, PA USA.
RP Williams, KE (reprint author), Penn State Hershey Med Ctr, Feeding Program, Hershey, PA 17033 USA.
EM kwilliams2@hmc.psu.edu
CR Alarcon PA, 2003, CLIN PEDIATR, V42, P209, DOI 10.1177/000992280304200304
   Bachmeyer MH, 2009, J APPL BEHAV ANAL, V42, P641, DOI 10.1901/jaba.2009.42-641
   Chillingworth A, 2012, ARCH DIS CHILD S, V97, pA108
   Field D, 2003, J PAEDIATR CHILD H, V39, P299, DOI 10.1046/j.1440-1754.2003.00151.x
   HANNING RM, 1993, AM J CLIN NUTR, V57, P580
   Hendy HM, 2009, APPETITE, V52, P328, DOI 10.1016/j.appet.2008.11.003
   Kalnin D, 1996, PEDIATR PULM, V13, P314
   Kuczmarski RJ, 2000, ADV DATA, V314, P1
   Luiselli JK, 2005, BEHAV INTERVENT, V20, P155, DOI 10.1002/bin.187
   MUNK DD, 1994, J APPL BEHAV ANAL, V27, P241, DOI 10.1901/jaba.1994.27-241
   Petty MLB, 2013, APPETITE, V62, P166, DOI 10.1016/j.appet.2012.11.024
   Poustie VJ, 2003, P NUTR SOC, V62, P801, DOI 10.1079/PNS2003295
   Rommel N, 2003, J PEDIATR GASTR NUTR, V37, P75, DOI 10.1097/00005176-200307000-00014
   Schwarz SM, 2001, PEDIATRICS, V108, P671, DOI 10.1542/peds.108.3.671
   Shaw RJ, 2003, CLIN CHILD PSYCHOL P, V8, P105
   Sleddens EFC, 2008, INT J BEHAV NUTR PHY, V5, DOI 10.1186/1479-5868-5-49
   Sullivan PB, 2000, DEV MED CHILD NEUROL, V42, P674, DOI 10.1017/S0012162200001249
   Wardle J, 2001, J CHILD PSYCHOL PSYC, V42, P963, DOI 10.1111/1469-7610.00792
   Williams KE, 2011, APPETITE, V56, P553, DOI 10.1016/j.appet.2011.01.021
NR 19
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1499-4046
EI 1878-2620
J9 J NUTR EDUC BEHAV
JI J. Nutr. Educ. Behav.
PD JUL-AUG
PY 2014
VL 46
IS 4
BP 236
EP 240
DI 10.1016/j.jneb.2014.01.003
PG 5
WC Education, Scientific Disciplines; Nutrition & Dietetics
SC Education & Educational Research; Nutrition & Dietetics
GA AP5RB
UT WOS:000342135300004
PM 24629907
ER

PT J
AU Kanemura, H
   Sano, F
   Ohyama, T
   Sugita, K
   Aihara, M
AF Kanemura, Hideaki
   Sano, Fumikazu
   Ohyama, Tetsuo
   Sugita, Kanji
   Aihara, Masao
TI Effect of levetiracetam on behavioral problems in pervasive
   developmental disorder children with epilepsy
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Article
DE Levetiracetam; Pervasive developmental disorder (PDD); Refractory
   epilepsy; EEG paroxysmal abnormalities; Behavior; Frontal
ID INTERICTAL EPILEPTIFORM DISCHARGES; AUTISM SPECTRUM DISORDERS; CHILDHOOD
   EPILEPSY; REFRACTORY EPILEPSY; EEG ABNORMALITIES; FOLLOW-UP; EFFICACY;
   SPIKES; FREQUENCY; SEIZURES
AB Aims: We investigated the relationship between behavioral problems, location of electroencephalogram (EEG) paroxysmal abnormalities (PA), and treatment with levetiracetam in children with pervasive developmental disorder (PDD) and epilepsy.
   Methods: Twelve PDD children with epilepsy were included in the study. All patients had EEG PA (frontal spikes, 8; rolandic, 3; generalized, 1). After a 3-month baseline period, patients were given levetiracetam with an initial dose of 10 mg/kg/day for the first week, followed by increments of 5 mg/kg/day every week. Levetiracetam dosage was then adjusted up to a maximum of 60 mg/kg/day. EEG recordings were performed every 3 months, focusing on PA frequency. We counted the frequency of seizures and EEG PA, and scored instances of panic/aggressive behaviors.
   Results: Eight (66.7%) of the 12 patients were considered to be responders to clinical seizures and EEG findings (>= 50% reduction in both seizures and PA frequency). Six (75%) of these eight patients were considered to be responders for behavioral problems (>= 50% reduction in panic/aggressive behavior). These six patients had frontal EEG paroxysms, whereas the remaining two patients without behavioral responses had rolandic EEG paroxysms. Patients with frontal PA showed a significantly higher correlation between EEG/clinical seizures and behavioral improvements (p < 0.05).
   Conclusion: The present data indicated the usefulness of LEV in reducing behavioral problems related to the reduction of seizures and frontal spikes in PDD for some but not all of the patients. Thus, levetiracetam represents an important addition to treatment for PDD children with epilepsy presenting with frontal EEG paroxysms. (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
C1 [Kanemura, Hideaki; Sano, Fumikazu; Ohyama, Tetsuo; Sugita, Kanji] Univ Yamanashi, Fac Med, Dept Paediat, Kofu, Yamanashi 4093898, Japan.
   [Aihara, Masao] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Kofu, Yamanashi 4093898, Japan.
RP Kanemura, H (reprint author), Univ Yamanashi, Fac Med, Dept Paediat, Chuo Ku, Kofu, Yamanashi 4093898, Japan.
EM ykimu@yamanashi.ac.jp
CR Aeby A, 2005, EPILEPSIA, V46, P1937, DOI 10.1111/j.1528-1167.2005.00337.x
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Anderson V, 2002, PRINCIPLES FRONTAL L, P504
   Bakke KA, 2011, EUR J PAEDIATR NEURO, V15, P532, DOI 10.1016/j.ejpn.2011.04.014
   Ben-Menachem E, 2003, SEIZURE-EUR J EPILEP, V12, P131, DOI 10.1016/S1059-1311(02)00251-0
   Besag FMC, 2002, J CHILD PSYCHOL PSYC, V43, P103, DOI 10.1111/1469-7610.00006
   Canitano R, 2007, EUR CHILD ADOLES PSY, V16, P61, DOI 10.1007/s00787-006-0563-2
   CAVAZZUTI GB, 1980, EPILEPSIA, V21, P43, DOI 10.1111/j.1528-1157.1980.tb04043.x
   Cereghino JJ, 2000, NEUROLOGY, V55, P236
   Dodson WE, 1993, PEDIAT EPILEPSY DIAG
   Gates John R., 2002, Epilepsia, V43, P187
   Goldberg E, 1987, FRONTAL LOBES REVISI, P159
   Hurtado B, 2006, EPILEPSY BEHAV, V8, P588, DOI 10.1016/j.yebeh.2006.01.003
   Kanemura H, 2013, EUR J PAEDIATR NEURO, V17, P232, DOI 10.1016/j.ejpn.2012.10.002
   Kanemura H, 2013, EPILEPSY BEHAV, V27, P443, DOI 10.1016/j.yebeh.2013.03.014
   Kanemura H, 2013, BRAIN DEV-JPN, V35, P386, DOI 10.1016/j.braindev.2012.07.005
   Kanemura H, 2012, BRAIN DEV-JPN, V34, P175, DOI 10.1016/j.braindev.2011.04.009
   Kanemura H, 2013, SEIZURE-EUR J EPILEP, V22, P43, DOI 10.1016/j.seizure.2012.10.003
   Kawasaki Y, 2010, BRAIN DEV-JPN, V32, P769, DOI 10.1016/j.braindev.2010.06.004
   Kossoff EH, 2001, EPILEPSIA, V42, P1611, DOI 10.1046/j.1528-1157.2001.32101.x
   Kurokawa T, 2010, BRAIN DEV-JPN, V32, P764, DOI 10.1016/j.braindev.2010.05.008
   Mesad Salah M., 2002, Epilepsia, V43, P208
   Mula M, 2004, SEIZURE-EUR J EPILEP, V13, P55, DOI 10.1016/S1059-1311(03)00111-0
   Mulligan CK, 2014, J AUTISM DEV DISORD, V44, P452, DOI 10.1007/s10803-013-1888-6
   Ong HT, 2000, NEUROLOGY, V54, P1182
   REY JM, 1995, J CHILD PSYCHOL PSYC, V36, P787, DOI 10.1111/j.1469-7610.1995.tb01329.x
   Specchio N, 2008, EPILEPSIA, V49, P663, DOI 10.1111/j.1528-1167.2007.01523.x
   Steffenburg S, 1996, ARCH NEUROL-CHICAGO, V53, P904
   Stodieck S, 2001, SEIZURE-EUR J EPILEP, V10, P583, DOI 10.1053/seiz.2001.0582
   Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6
   Wolff M, 2005, EPILEPSIA, V46, P1661, DOI 10.1111/j.1528-1167.2005.00255.x
NR 31
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
EI 1532-2130
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD JUL
PY 2014
VL 18
IS 4
BP 482
EP 488
DI 10.1016/j.ejpn.2014.03.007
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA AL0OA
UT WOS:000338825000005
PM 24703761
ER

PT J
AU Banji, D
   Banji, OJF
   Ragini, M
   Annamalai, AR
AF Banji, David
   Banji, Otilia J. F.
   Ragini, M.
   Annamalai, A. R.
TI Carbosulfan exposure during embryonic period can cause developmental
   disability in rats
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Carbosulfan; Embryonic period; Behavior; Acetylcholinesterase; Oxidative
   stress
ID ACETYLCHOLINESTERASE ACTIVITY; PESTICIDES; ECOTOXICITY; GLUTATHIONE;
   CEREBELLUM; CARBOFURAN; REDUCTASE; SYSTEM; AUTISM; BRAIN
AB Carbosulfan, a wide spectrum pesticide is used to improve crop productivity. During their application, they disperse in the environment exerting harmful consequences on human health. We speculated that exposure to carbosulfan, a carbamate insecticide during early development can affect neurogenesis and synaptic development. In order to test this, pregnant dams were exposed to carbosulfan in four doses (0.5, 1, 2, and 4 mg/kg) during the embryonic period (ED 1-15). Offspring were evaluated for neurobehavioral changes, oxidative markers, acetylcholinesterase levels, and formation of carbonylated proteins. Histopathology of the cerebellum was carried out. Carbosulfan exposure produced alteration in sensorimotor tasks, motor function and elevated anxiety in pups. Carbosulfan affected growth rate of pups in a dose dependent manner. A significant increase in melondialdehyde, a lipid peroxide marker, carbonylated proteins and a dose dependent decrease in the levels of glutathione and glutathione peroxidase were observed. Carbosulfan produced a decline in acetylcholinesterase levels which might contribute to poor exploratory behavior. Distinct changes in the Purkinje cells were observed as the dose of carbosulfan increased. Largely, alteration in behavior can be due to oxidative damage, thereby, affecting neurogenesis, synaptogenesis and myelination. Therefore the propensity of carbosulfan to induce developmental disability is high and should be cautiously avoided during embryonic development. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Banji, David; Banji, Otilia J. F.; Ragini, M.] Nalanda Coll Pharm, Dept Pharmacol & Toxicol, Nalgonda 508001, Andhra Pradesh, India.
   [Annamalai, A. R.] Annamalai Univ, Rajah Muthiah Med Coll, Dept Pharmacol, Chidambaram, Tamil Nadu, India.
RP Banji, D (reprint author), Nalanda Coll Pharm, Dept Pharmacol & Toxicol, Hyderabad Rd, Nalgonda 508001, Andhra Pradesh, India.
EM davidbanji@gmail.com
FU Nalanda Educational Society, Nalgonda, Andhra Pradesh, India
   [NES/55/RG/2012]
FX The authors express their gratitude to Nalanda Educational Society,
   grant number is NES/55/RG/2012 dated 15-11-2012, Nalgonda 508001, Andhra
   Pradesh, India for providing financial support and facilities for
   carrying out this work.
CR Acosta Maria, 2002, Adv Pediatr, V49, P1
   Altman J., 1996, DEV CEREBELLAR SYSTE, P726
   Barone S, 2000, NEUROTOXICOLOGY, V21, P15
   Bretaud S, 2000, ECOTOX ENVIRON SAFE, V47, P117, DOI 10.1006/eesa.2000.1954
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Cheh MA, 2006, BRAIN RES, V1116, P166, DOI 10.1016/j.brainres.2006.07.086
   Cronin MTD, 2002, SAR QSAR ENVIRON RES, V13, P167, DOI 10.1080/10629360290002316
   Curthoys I.S., 1983, DEV AUDITORY VESTIBU, P425
   Diamond A, 2000, CHILD DEV, V71, P44, DOI 10.1111/1467-8624.00117
   Ecobichon D.J., 1990, EFFECT PESTICIDES HU, P131
   El-Alfy AT, 2002, AQUAT TOXICOL, V61, P225, DOI 10.1016/S0166-445X(02)00059-0
   ELLMAN GL, 1961, BIOCHEM PHARMACOL, V7, P88, DOI 10.1016/0006-2952(61)90145-9
   Filho MVS, 2004, TOXICOL LETT, V153, P247, DOI 10.1016/j.toxlet.2004.04.026
   Food and Agricultural Organization (FAO), 2002, FAO WHO GLOB FOR FOO
   Golombieski JI, 2008, SCI AGR, V65, P340, DOI 10.1590/S0103-90162008000400003
   Guillet P, 2001, MED VET ENTOMOL, V15, P105, DOI 10.1046/j.1365-2915.2001.00288.x
   HOGBERG J, 1974, BIOCHEM BIOPH RES CO, V56, P836, DOI 10.1016/0006-291X(74)90681-0
   Iesce MR, 2006, ENVIRON SCI POLLUT R, V13, P105, DOI 10.1065/espr2005.10.285
   JMPR, 1987, 782 FAO PLANT PROD P
   JMPR, 2004, WHOPCS041
   JMPR, 2004, 176 FAO PLANT PROD P
   Kahne D, 2002, PHYSIOL BEHAV, V75, P403, DOI 10.1016/S0031-9384(01)00673-4
   Kihara T, 2000, TOXICOL SCI, V53, P392, DOI 10.1093/toxsci/53.2.392
   Leo AJ, 1999, PERSPECT DRUG DISCOV, V17, P1, DOI 10.1023/A:1008762321231
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Lionetto MG, 2003, MAR POLLUT BULL, V46, P324, DOI 10.1016/S0025-326X(02)00403-4
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Maran E, 2009, ECOTOX ENVIRON SAFE, V72, P922, DOI 10.1016/j.ecoenv.2008.01.018
   Miron DD, 2008, CHEMOSPHERE, V74, P1, DOI 10.1016/j.chemosphere.2008.09.070
   Mishra D, 2012, TOXICOL SCI, V127, P84, DOI 10.1093/toxsci/kfs004
   Modesto KA, 2010, CHEMOSPHERE, V78, P294, DOI 10.1016/j.chemosphere.2009.10.047
   MORON MS, 1979, BIOCHIM BIOPHYS ACTA, V582, P67, DOI 10.1016/0304-4165(79)90289-7
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Parveen Z, 2004, B ENVIRON CONTAM TOX, V73, P312, DOI 10.1007/s00128-004-0429-6
   PELLOW S, 1985, J NEUROSCI METH, V14, P149, DOI 10.1016/0165-0270(85)90031-7
   PIMENTEL D, 1995, J AGR ENVIRON ETHIC, V8, P17, DOI 10.1007/BF02286399
   Repetto R., 1996, PESTICIDES IMMUNE SY
   RODIER PM, 1979, TERATOLOGY, V19, P327, DOI 10.1002/tera.1420190308
   RODIER PM, 1976, ENVIRON HEALTH PERSP, V18, P79, DOI 10.2307/3428687
   RODIER PM, 1980, DEV MED CHILD NEUROL, V22, P525
   Sankararamakrishnan N., 2005, INDIA ENV INT, V31, P113
   Segerstrom SC, 2004, PSYCHOL BULL, V130, P601, DOI 10.1037/0033-2909.130.4.601
   Soler C, 2006, ANAL CHIM ACTA, V571, P1, DOI 10.1016/j.aca.2006.04.033
   STEHRERSCHMID P, 1995, MUTAT RES-REV GENET, V339, P61, DOI 10.1016/0165-1110(94)00015-5
   Sverdrup LE, 2002, ENVIRON SCI TECHNOL, V36, P2429, DOI 10.1021/es010180s
   Thach WT, 1998, NEUROBIOL LEARN MEM, V70, P177, DOI 10.1006/nlme.1998.3846
   Tuker J.W., 1987, AQUACULT MAG, V13, P62
   U.S. EPA, 1996, COMP EPAS SAMPL AN M
   VORHEES CV, 1983, J PHARMACOL EXP THER, V227, P274
   WHO, 2009, WHO REC CLASS PEST H
   Wilson C, 2001, ECOL ECON, V39, P449, DOI 10.1016/S0921-8009(01)00238-5
   Wubbels RJ, 2000, BRAIN RES BULL, V52, P349, DOI 10.1016/S0361-9230(00)00279-3
NR 52
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD JUL
PY 2014
VL 38
IS 1
BP 230
EP 238
DI 10.1016/j.etap.2014.05.009
PG 9
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA AO6NN
UT WOS:000341468900025
PM 24973665
ER

PT J
AU Daunhauer, LA
   Fidler, DJ
   Hahn, L
   Will, E
   Lee, NR
   Hepburn, S
AF Daunhauer, Lisa A.
   Fidler, Deborah J.
   Hahn, Laura
   Will, Elizabeth
   Lee, Nancy Raitano
   Hepburn, Susan
TI Profiles of Everyday Executive Functioning in Young Children With Down
   Syndrome
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE executive function; cognition; Down syndrome; trisomy 21
ID BEHAVIOR RATING INVENTORY; CONFIRMATORY FACTOR-ANALYSIS; PREFRONTAL
   CORTEX; PRESCHOOL-CHILDREN; EFFORTFUL CONTROL; UNITED-STATES; FRAGILE-X;
   MEMORY; DISORDERS; AUTISM
AB We investigated executive functioning (EF) in children with Down syndrome (DS; n = 25) and typically developing (TD) children matched for mental age (MA; n = 23) using the Behavior Rating Inventory of Executive Function-Preschool. We sought to (1) compare children with DS to a developmentally matched control group, and (2) to characterize the EF profile of children with DS. Across teacher and parent reports, significant deficits in working memory and planning were observed in the DS group. Parents, but not teachers, of children with DS also reported difficulties in inhibitory control relative to the comparison group. Results extend earlier findings regarding EF impairments in children with DS. The complementary role inhibitory control may play in this profile is discussed.
C1 [Daunhauer, Lisa A.; Fidler, Deborah J.; Will, Elizabeth] Colorado State Univ, Ft Collins, CO 80523 USA.
   [Hahn, Laura] Univ Kansas, Lawrence, KS 66045 USA.
   [Lee, Nancy Raitano] NIMH, Bethesda, MD USA.
   [Hepburn, Susan] Univ Colorado, Sch Med, Boulder, CO 80309 USA.
RP Daunhauer, LA (reprint author), Colorado State Univ, Room 447,Behav Sci Bldg, Ft Collins, CO 80523 USA.
EM Lisa.Daunhauer@colostate.edu
CR Baddeley A, 2007, J INTELL DISABIL RES, V51, P925, DOI 10.1111/j.1365-2788.2007.00979.x
   Bakar EE, 2011, KLIN PSIKOFARMAKOL B, V21, P302, DOI 10.5455/BCP.20111004014003
   Blair C, 2007, CHILD DEV, V78, P647, DOI 10.1111/j.1467-8624.2007.01019.x
   Brock LL, 2009, EARLY CHILD RES Q, V24, P337, DOI 10.1016/j.ecresq.2009.06.001
   Canfield MA, 2006, BIRTH DEFECTS RES A, V76, P747, DOI 10.1002/bdra.20294
   Carlson SA, 2005, DEV NEUROPSYCHOL, V28, P595, DOI 10.1207/s15326942dn2802_3
   Carrow-Woolfolk E., 1995, ORAL WRITTEN LANGUAG
   Carrow-Woolfolk E., 2008, ORAL WRITTEN LANGUAG
   Cebula KR, 2010, J INTELL DISABIL RES, V54, P113, DOI 10.1111/j.1365-2788.2009.01215.x
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Conners F. A., 2003, SPEECH LANGUAGE INTE, P31
   Conners FA, 2008, J INTELL DISABIL RES, V52, P244, DOI 10.1111/j.1365-2788.2007.01015.x
   Daunhauer Lisa A, 2011, Occup Ther Health Care, V25, P7, DOI 10.3109/07380577.2010.535601
   Dawson G, 1998, CHILD DEV, V69, P1276, DOI 10.2307/1132265
   Diamond A, 2001, DEV COGN NEUROSCI, P433
   DIAMOND A, 1990, ANN NY ACAD SCI, V608, P637, DOI 10.1111/j.1749-6632.1990.tb48913.x
   DIAMOND A, 1985, CHILD DEV, V56, P868, DOI 10.1111/j.1467-8624.1985.tb00160.x
   Diamond A, 2000, CHILD DEV, V71, P44, DOI 10.1111/1467-8624.00117
   Diamond A, 2007, SCIENCE, V318, P1387, DOI 10.1126/science.1151148
   Diamond A., 2002, PRINCIPLES FRONTAL L, P466, DOI [10.1093/acprof:oso/9780195134971.003.0029, DOI 10.1093/ACPROF:OSO/9780195134971.003.0029]
   Dykens EM, 2007, MENT RETARD DEV D R, V13, P272, DOI 10.1002/mrdd.20159
   Edgin J. O., 2003, THESIS DENVER U DENV
   Edgin JO, 2010, J INTELL DISABIL RES, V54, P406, DOI 10.1111/j.1365-2788.2010.01278.x
   Fidler DJ, 2005, AM J OCCUP THER, V59, P129
   Garon N, 2008, PSYCHOL BULL, V134, P31, DOI 10.1037/0033-2909.134.1.31
   Gioia G. A., 2003, BEHAV RATING INVENTO
   Gioia GA, 2010, J HEAD TRAUMA REHAB, V25, P433, DOI 10.1097/HTR.0b013e3181fbc272
   Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P249, DOI 10.1076/chin.8.4.249.13513
   Gioia GA, 2000, CHILD NEUROPSYCHOL, V6, P235, DOI 10.1076/chin.6.3.235.3152
   Haydar T. F., 2011, TRENDS NEUROSCI, V35, P81, DOI 10.1016/j.tins.2011.11.001
   Hongwanishkul D, 2005, DEV NEUROPSYCHOL, V28, P617, DOI 10.1207/s15326942dn2802_4
   Hughes C, 2011, INFANT CHILD DEV, V20, P251, DOI 10.1002/icd.736
   Hulme C., 1992, WORKING MEMORY SEVER
   JERNIGAN TL, 1990, ARCH NEUROL-CHICAGO, V47, P529
   Kasari C, 2001, AM J MENT RETARD, V106, P253, DOI 10.1352/0895-8017(2001)106<0253:TRSBIC>2.0.CO;2
   Kogan CS, 2009, J INTELL DISABIL RES, V53, P125, DOI 10.1111/j.1365-2788.2008.01135.x
   KOPP CB, 1983, AM J MENT DEF, V88, P164
   Lee NR, 2011, AJIDD-AM J INTELLECT, V116, P290, DOI 10.1352/1944-7558-116.4.290
   Lee NR, 2010, J NEURODEV DISORD, V2, P9, DOI 10.1007/s11689-009-9029-4
   Lehto JE, 2003, BRIT J DEV PSYCHOL, V21, P59, DOI 10.1348/026151003321164627
   Mahone EM, 2007, CLIN NEUROPSYCHOL, V21, P569, DOI 10.1080/13854040600762724
   McAuley T, 2010, J INT NEUROPSYCH SOC, V16, P495, DOI 10.1017/S1355617710000093
   McClelland MM, 2007, DEV PSYCHOL, V43, P947, DOI 10.1037/0012-1649.43.4.947
   Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
   Morrison AB, 2011, PSYCHON B REV, V18, P46, DOI 10.3758/s13423-010-0034-0
   Murray KT, 2002, J ABNORM CHILD PSYCH, V30, P503, DOI 10.1023/A:1019821031523
   Nadel L, 2003, GENES BRAIN BEHAV, V2, P156, DOI 10.1034/j.1601-183X.2003.00026.x
   Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Pennington BF, 2003, CHILD DEV, V74, P75, DOI 10.1111/1467-8624.00522
   Portney L. G., 2009, FDN CLIN RES APPL PR
   Riggs N, 2010, CHILD NEUROPSYCHOL, V16, P279, DOI 10.1080/09297041003601488
   Riggs NR, 2011, INHIBITORY CONTROL AND DRUG ABUSE PREVENTION: FROM RESEARCH TO TRANSLATION, P249, DOI 10.1007/978-1-4419-1268-8_13
   Roid G., 1997, LEITER INT PERFORMAN
   Roid G. H., 1995, LEITER INT PERFORMAN
   Rowe J, 2006, BRIT J CLIN PSYCHOL, V45, P5, DOI 10.1348/014466505X29594
   Seltzer MM, 2004, J AUTISM DEV DISORD, V34, P41, DOI 10.1023/B:JADD.0000018073.92982.64
   Shin M, 2009, PEDIATRICS, V124, P1565, DOI 10.1542/peds.2009-0745
   Tau GZ, 2010, NEUROPSYCHOPHARMACOL, V35, P147, DOI 10.1038/npp.2009.115
   Thomas M, 2002, BEHAV BRAIN SCI, V25, P727, DOI 10.1017/S0140525X02000134
   Tsujimoto S, 2008, NEUROSCIENTIST, V14, P345, DOI 10.1177/1073858408316002
   White NS, 2003, NEUROIMAGE, V20, P393, DOI 10.1016/S1053-8119(03)00273-8
   Wiebe SA, 2008, DEV PSYCHOL, V44, P575, DOI 10.1037/0012-1649.44.2.575
   Zelazo PD, 2005, YOUNG CHILDREN'S COGNITIVE DEVELOPMENT: INTERRELATIONSHIPS AMONG EXECUTIVE FUNCTIONING, WORKING MEMORY, VERBAL ABILITY, AND THEORY OF MIND, P71
   Zelazo P. D., 1997, REV GEN PSYCHOL, V1, P198, DOI DOI 10.1037/1089-2680.1.2.198
   Zelazo P. D., 2011, WILEY BLACKWELL HDB, P574, DOI DOI 10.1002/9781444325485.CH22
   Zingerevich C, 2009, RES AUTISM SPECT DIS, V3, P429, DOI 10.1016/j.rasd.2008.09.002
NR 67
TC 2
Z9 2
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JUL
PY 2014
VL 119
IS 4
BP 303
EP 318
DI 10.1352/1944-7558-119.4.303
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XP
UT WOS:000341270900002
PM 25007296
ER

PT J
AU Turkstra, LS
   Abbeduto, L
   Meulenbroek, P
AF Turkstra, Lyn S.
   Abbeduto, Leonard
   Meulenbroek, Peter
TI Social Cognition in Adolescent Girls With Fragile X Syndrome
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE social cognition; fragile X syndrome; executive function; social
   outcome; adolescent
ID TRAUMATIC BRAIN-INJURY; HIGH-FUNCTIONING AUTISM; THEORY-OF-MIND;
   EXECUTIVE FUNCTION; ASPERGER-SYNDROME; FRONTOTEMPORAL DEMENTIA; LANGUAGE
   IMPAIRMENT; TURNER-SYNDROME; SELF-CONCEPT; EYES TEST
AB This study aimed to characterize social cognition, executive functions (EFs), and everyday social functioning in adolescent girls with fragile X syndrome, and identify relationships among these variables. Participants were 20 girls with FXS and 20 age-matched typically developing peers. Results showed significant between-groups differences in social cognition, accounted for by differences in IQ and language. Within the FXS group, IQ and language were related to social cognition; parent-reported social functioning was related to language and EFs; and self-reported social functioning was generally good and not related to cognitive or social cognition variables. Results suggest that intervention might focus on managing language and cognitive contributions to social functioning, rather than social cognition, and underscore the importance of considering parent and adolescent perspectives.
C1 [Turkstra, Lyn S.] Univ Wisconsin, Dept Commun Sci & Disorders, Madison, WI 53706 USA.
   [Abbeduto, Leonard] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA.
   [Abbeduto, Leonard] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95616 USA.
   [Meulenbroek, Peter] Univ Wisconsin, Madison, WI 53706 USA.
RP Turkstra, LS (reprint author), Univ Wisconsin, Dept Commun Sci & Disorders, 1975 Willow Dr, Madison, WI 53706 USA.
EM lsturkstra@wisc.edu
CR Achenbach T. M, 1980, CHILD BEHAV CHECKLIS
   Adolphs R, 1999, TRENDS COGN SCI, V3, P469, DOI 10.1016/S1364-6613(99)01399-6
   Adrian JE, 2005, J CHILD LANG, V32, P673, DOI 10.1017/S0305000905006963
   Ahmed FS, 2011, J AUTISM DEV DISORD, V41, P667, DOI 10.1007/s10803-010-1087-7
   American Educational Research Association American Psychological Association & National Council on Measurement in Education, 1999, STAND ED PSYCH TEST
   Ames DR, 2004, J NONVERBAL BEHAV, V28, P187, DOI 10.1023/B:JONB.0000039649.20015.0e
   Anderson P., 2000, CLIN NEUROPSYCHOL, V1, P247
   Armor DA, 1998, ADV EXP SOC PSYCHOL, V30, P309
   Banerjee R, 2001, SOC DEV, V10, P558, DOI 10.1111/1467-9507.00180
   Banerjee R, 2011, CHILD DEV, V82, P1887, DOI 10.1111/j.1467-8624.2011.01669.x
   Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   BAUMEISTER RF, 1995, PSYCHOL BULL, V117, P497, DOI 10.1037/0033-2909.117.3.497
   Bora E, 2006, PSYCHIAT RES, V145, P95, DOI 10.1016/j.psychres.2005.11.003
   Bowie CR, 2005, PSYCHIAT CLIN N AM, V28, P613, DOI 10.1016/j.psc.2005.05.004
   Burgess PW, 1998, J INT NEUROPSYCH SOC, V4, P547
   Burgess S, 2010, LANG SPEECH HEAR SER, V41, P474, DOI 10.1044/0161-1461(2010/09-0007)
   Carrow-Woolfolk E, 1999, COMPREHENSIVE ASSESS
   CAVELL TA, 1990, J CLIN CHILD PSYCHOL, V19, P111, DOI 10.1207/s15374424jccp1902_2
   Channon Shelley, 2003, Cogn Neuropsychiatry, V8, P243, DOI 10.1080/135468000344000002
   Ciccia AH, 2009, TOP LANG DISORD, V29, P249
   Cornish K, 2005, BRAIN COGNITION, V57, P53, DOI 10.1016/j.bandc.2004.08.020
   Cornish K, 2005, J INTELL DISABIL RES, V49, P372, DOI 10.1111/j.1365-2788.2005.00678.x
   Cornish KM, 1998, NEUROPSYCHOLOGIA, V36, P1239, DOI 10.1016/S0028-3932(97)00162-0
   Cornish KM, 2001, J COGNITIVE NEUROSCI, V13, P144, DOI 10.1162/089892901564126
   Crawford DC, 2001, GENET MED, V3, P359, DOI 10.1097/00125817-200109000-00006
   Crone EA, 2012, NAT REV NEUROSCI, V13, P636, DOI 10.1038/nrn3313
   Daley TC, 2003, MED ANTHROPOL Q, V17, P25, DOI 10.1525/maq.2003.17.1.25
   Eddy CM, 2012, ACTA NEUROL SCAND, V126, P376, DOI 10.1111/j.1600-0404.2012.01659.x
   Flesch R., 1994, WRITE SPEAK THINK MO
   FREUND LS, 1993, PEDIATRICS, V91, P321
   Gioia G. A, 2006, TESTS EXECUTIVE CONT
   Gregory C, 2002, BRAIN, V125, P752, DOI 10.1093/brain/awf079
   Hagerman R. J, 1999, NEURODEVELOPMENTAL D
   HAGERMAN RJ, 1992, PEDIATRICS, V89, P395
   Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
   Harter S, 1988, MANUAL SELF PERCEPTI
   Harter S., 1985, MANUAL SELF PERCEPTI
   Hartley SL, 2011, AJIDD-AM J INTELLECT, V116, P16, DOI 10.1352/1944-7558-116.1.16
   Heaton RK, 1981, WISCONSIN CARD SORTI
   Hendry LB, 2000, J ADOLESCENCE, V23, P705, DOI 10.1006/jado.2000.0354
   Hessl D, 2004, MENT RETARD DEV D R, V10, P17, DOI 10.1002/mrdd.20004
   Hessl D, 2002, PSYCHONEUROENDOCRINO, V27, P855, DOI 10.1016/S0306-4530(01)00087-7
   Hoffman KB, 2000, J ABNORM PSYCHOL, V109, P651, DOI 10.1037//0021-843X.109.4.4.651
   Hughes DM, 2009, INT J LANG COMM DIS, V44, P901, DOI [10.1080/13682820802425693, 10.3109/13682820802425693]
   Isquith P. K., 2010, TASKS EXECUTIVE CONT
   John K, 2001, CHILD PSYCHOL PSYCHI, V6, P181, DOI 10.1111/1475-3588.00343
   Jones JL, 2012, INTELLECT DEV DISAB, V50, P31, DOI 10.1352/1934-9556-50.1.31
   Keysor CS, 2002, MICROSC RES TECHNIQ, V57, P179, DOI 10.1002/jemt.10070
   Keysor CS, 2002, DEV PSYCHOBIOL, V41, P133, DOI 10.1002/dev.10060
   Kirk JW, 2005, DEV NEUROPSYCHOL, V28, P755, DOI 10.1207/s15326942dn2803_2
   KURDEK LA, 1994, CHILD DEV, V65, P1137
   Larson R., 1984, BEING ADOLESCENT CON
   LARSON RW, 1983, J MARRIAGE FAM, V45, P739, DOI 10.2307/351787
   Lough S, 2006, NEUROPSYCHOLOGIA, V44, P950, DOI 10.1016/j.neuropsychologia.2005.08.009
   Mailloux S L, 1995, Comput Nurs, V13, P221
   Marschark M, 2000, J CHILD PSYCHOL PSYC, V41, P1067, DOI 10.1017/S0021963099006496
   Martin-Rodriguez JF, 2010, NEUROPSYCHOLOGIA, V48, P1181, DOI 10.1016/j.neuropsychologia.2010.02.009
   MAZZOCCO MMM, 1994, J AUTISM DEV DISORD, V24, P473, DOI 10.1007/BF02172129
   MAZZOCCO MMM, 1993, J DEV BEHAV PEDIATR, V14, P328
   McDonald S., 2002, AWARENESS SOCIAL INF
   Mesulam M. M., 2002, PRINCIPLES FRONTAL L, P8, DOI [10.1093/acprof:oso/9780195134971.003.0002, DOI 10.1093/ACPROF:OSO/9780195134971.003.0002]
   Miller CA, 2004, INT J LANG COMM DIS, V39, P191, DOI 10.1080/13682820310001616994
   Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
   Muller F, 2010, CORTEX, V46, P1088, DOI 10.1016/j.cortex.2009.08.014
   Pakaslahti L., 2000, EDUC PSYCHOL, V20, P177, DOI [10.1080/713663710, DOI 10.1080/713663710]
   Perner J, 1999, DEVELOPING THEORIES OF INTENTION, P133
   Peterson E, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00220
   Pyers J., 1997, P 21 ANN BOST U C LA, V1, P136
   RAFFAELLI M, 1989, J YOUTH ADOLESCENCE, V18, P567, DOI 10.1007/BF02139074
   Roid G., 1997, LEITER INT PERFORMAN
   Russell PA, 1998, J CHILD PSYCHOL PSYC, V39, P903, DOI 10.1017/S0021963098002844
   Sabbagh MA, 2004, BRAIN COGNITION, V55, P209, DOI 10.1016/j.banc.2003.04.002
   Shapka JD, 2005, CAN J BEHAV SCI, V37, P83, DOI 10.1037/h0087247
   Siegal M, 2002, NAT REV NEUROSCI, V3, P463, DOI 10.1038/nrn844
   Simon JA, 2001, COGNITIVE NEUROPSYCH, V18, P1, DOI 10.1080/02643290126042
   Sobesky WE, 1996, AM J MED GENET, V64, P340, DOI 10.1002/(SICI)1096-8628(19960809)64:2<340::AID-AJMG21>3.0.CO;2-E
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Stuss DT, 2000, PSYCHOL RES-PSYCH FO, V63, P289, DOI 10.1007/s004269900007
   Sumter SR, 2009, J ADOLESCENCE, V32, P1009, DOI 10.1016/j.adolescence.2008.08.010
   Sutterby SR, 2012, PSYCHIAT RES, V197, P242, DOI 10.1016/j.psychres.2012.02.014
   TAYLOR SE, 1988, PSYCHOL BULL, V103, P193, DOI 10.1037/0033-2909.103.2.193
   Todd SY, 2003, ADOLESCENCE, V38, P659
   Turkstra L, 2005, J MED SPEECH-LANG PA, V13, pIX
   Turkstra LS, 2001, J HEAD TRAUMA REHAB, V16, P469, DOI 10.1097/00001199-200110000-00006
   Turkstra LS, 1996, BRAIN INJURY, V10, P329, DOI 10.1080/026990596124359
   Turkstra LS, 2004, NEUROREHABILITATION, V19, P245
   Turkstra LS, 2008, BRAIN INJURY, V22, P397, DOI 10.1080/02699050802027059
   Wang YG, 2008, PSYCHIAT RES, V161, P153, DOI 10.1016/j.psychres.2007.07.018
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   WICHSTROM L, 1995, J PERS ASSESS, V65, P100, DOI 10.1207/s15327752jpa6501_8
   Wilding J, 2002, NEUROPSYCHOLOGIA, V40, P1343, DOI 10.1016/S0028-3932(01)00212-3
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
   World Health Organisation, 2001, INT CLASS FUNCT DIS
   Zelazo PD, 1996, J CHILD PSYCHOL PSYC, V37, P479, DOI 10.1111/j.1469-7610.1996.tb01429.x
NR 99
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JUL
PY 2014
VL 119
IS 4
BP 319
EP 339
DI 10.1352/1944-7558-119.4.319
PG 21
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XP
UT WOS:000341270900003
PM 25007297
ER

PT J
AU Schroeder, SR
   Marquis, JG
   Reese, RM
   Richman, DM
   Mayo-Ortega, L
   Oyama-Ganiko, R
   LeBlanc, J
   Brady, N
   Butler, MG
   Johnson, T
   Lawrence, L
AF Schroeder, Stephen R.
   Marquis, Janet G.
   Reese, R. Matthew
   Richman, David M.
   Mayo-Ortega, Liliana
   Oyama-Ganiko, Rosa
   LeBlanc, Judith
   Brady, Nancy
   Butler, Merlin G.
   Johnson, Tiffany
   Lawrence, Linda
TI Risk Factors for Self-Injury, Aggression, and Stereotyped Behavior Among
   Young Children At Risk for Intellectual and Developmental Disabilities
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE aggression; self-injurious behavior; stereotyped behavior; infants;
   toddlers; intellectual and developmental disabilities
ID AUTISM SPECTRUM DISORDER; LONG-TERM TREATMENT; CHALLENGING BEHAVIORS;
   PROBLEMS-INVENTORY; INFANT SCREEN; REPETITIVE-BEHAVIOR;
   MENTAL-RETARDATION; ANIMAL-MODELS; TODDLERS; INDIVIDUALS
AB Before the 1990s, research on the early identification and prevention of severe behavior disorders (SBDs), such as aggression, self-injury, and stereotyped behavior, among young children with intellectual and developmental disabilities (IDD), was mostly done with children 3 years or older. More recent work suggests that signs of SBDs may occur as early as 6 months in some infants. The present study combined a cross-sectional and longitudinal approach to examine SBDs in 180 young children aged 4-48 months recruited through mass screening, then receiving an interdisciplinary evaluation and sixmonth follow-ups for one year. Twelve potential risk factors related to SBDs were examined. Eight of these risk factors, including age, gender, diagnosis, intellectual and communication levels, visual impairment, parent education, family income, were differentially related to scores for Aggression, SIB, and Stereotyped Behavior subscales on the Behavior Problems Inventory (BPI-01) at initial interdisciplinary evaluation. BPI-01 scores decreased over the year for 57% of the children and increased for 43%. The amount of decrease on each BPI-01 subscale varied with age, gender, and diagnosis.
C1 [Schroeder, Stephen R.; LeBlanc, Judith] Univ Kansas, Life Span Inst, Lawrence, KS 66045 USA.
   [Marquis, Janet G.; Reese, R. Matthew; Brady, Nancy] Univ Kansas, Lawrence, KS 66045 USA.
   [Richman, David M.] Texas Tech Univ, Lubbock, TX 79409 USA.
   [Mayo-Ortega, Liliana; Oyama-Ganiko, Rosa] Ctr Ann Sullivan Peru, Lima, Peru.
   [Butler, Merlin G.; Johnson, Tiffany; Lawrence, Linda] Univ Kansas, Med Ctr, Lawrence, KS 66045 USA.
RP Schroeder, SR (reprint author), Univ Kansas, Life Span Inst, 1000 Sunnyside Ave, Lawrence, KS 66045 USA.
EM srs@ku.edu
CR Aman M. G., 1994, ABERRANT BEHAV CHE S
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Baker BL, 2002, AM J MENT RETARD, V107, P433, DOI 10.1352/0895-8017(2002)107<0433:BPAPSI>2.0.CO;2
   Bayley N., 2006, MANUAL BAYLEY SCALES, V3rd
   Berkson G, 2001, AM J MENT RETARD, V106, P539, DOI 10.1352/0895-8017(2001)106<0539:EDOSAS>2.0.CO;2
   Berkson G, 2002, AM J MENT RETARD, V107, P468, DOI 10.1352/0895-8017(2002)107<0468:EDOSAS>2.0.CO;2
   Berkson G, 2000, J EARLY INTERVENTION, V23, P1, DOI 10.1177/10538151000230010401
   Berkson G., 1967, COMP PSYCHOPATHOLOGY, P76
   Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
   Bruininks R. H., 1986, INVENTORY CLIENT AGE
   Carr E., 1995, MENTAL RETARDATION D, V1, P94, DOI DOI 10.1002/MRDD.1410010204
   Cohen J, 1988, STAT POWER BEHAV SCI
   Damiano CR, 2013, J AUTISM DEV DISORD, V43, P1326, DOI 10.1007/s10803-012-1681-y
   Dawson G, 1996, J AUTISM DEV DISORD, V26, P179, DOI 10.1007/BF02172008
   Dunlap G, 2006, BEHAV DISORDERS, V32, P29
   Fodstad JC, 2012, J DEV PHYS DISABIL, V24, P217, DOI 10.1007/s10882-011-9266-9
   GUESS D, 1991, AM J MENT RETARD, V96, P299
   Hastings RP, 2002, AM J MENT RETARD, V107, P455, DOI 10.1352/0895-8017(2002)107<0455:DCBASP>2.0.CO;2
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P215, DOI 10.1901/jaba.1994.27-215
   Karabekiroglu K, 2009, CHILD PSYCHIAT HUM D, V40, P99, DOI 10.1007/s10578-008-0108-7
   Keller K. M., 2009, EARLY CHILD DEV CARE, V170, P87
   KRAVITZ H, 1971, CHILD DEV, V42, P399, DOI 10.1111/j.1467-8624.1971.tb03647.x
   Kurtz PF, 2012, J MENT HEALTH RES IN, V5, P260, DOI 10.1080/19315864.2011.600809
   LEWIS MH, 1982, INT REV RES MENT RET, V11, P123, DOI 10.1016/S0074-7750(08)60291-8
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   MacLean WE, 2012, J MENT HEALTH RES IN, V5, P236, DOI 10.1080/19315864.2011.590627
   MacLean WE, 2010, J PEDIATR-US, V157, P979, DOI 10.1016/j.jpeds.2010.05.052
   MARSHBURN EC, 1992, J AUTISM DEV DISORD, V22, P357, DOI 10.1007/BF01048240
   Matson J, 2009, J MENT HEALTH RES IN, V2, P169, DOI 10.1080/19315860902725875
   Matson J. L., 2005, ED PSYCHOL, V25, P151, DOI DOI 10.1080/0144341042000301148
   Matson JL, 2010, J MENT HEALTH RES IN, V3, P164, DOI 10.1080/19315864.2010.495920
   Matson JL, 2009, DEV NEUROREHABIL, V12, P381, DOI 10.3109/17518420903029501
   Matson JL, 2008, RES DEV DISABIL, V29, P141, DOI 10.1016/j.ridd.2007.02.001
   Matson JL, 2012, RES AUTISM SPECT DIS, V6, P1135, DOI 10.1016/j.rasd.2012.02.009
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Matson JL, 2010, DEV NEUROREHABIL, V13, P3, DOI 10.3109/17518420903074887
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P300, DOI 10.1016/j.rasd.2009.10.001
   Mayo-Ortega L, 2012, J MENT HEALTH RES IN, V5, P246, DOI 10.1080/19315864.2011.590626
   McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
   Medeiros K, 2012, RES DEV DISABIL, V33, P1110, DOI 10.1016/j.ridd.2012.02.005
   Murphy G, 1999, J INTELL DISABIL RES, V43, P149, DOI 10.1046/j.1365-2788.1999.00183.x
   Newborg J., 2005, BATELLE DEV INVENTOR
   Oliver C., 2012, J AUTISM DEV DISORD, V49, P910
   Oyama-Ganiko R., 2013, REV EDUCACAO ESPECIA, V26, P541
   Rethmeyer J. A., 2012, CLIN CHEM LAB MED, V1505, P1
   Richards C, 2012, J INTELL DISABIL RES, V56, P476, DOI 10.1111/j.1365-2788.2012.01537.x
   Richman DM, 2008, J INTELL DISABIL RES, V52, P3, DOI 10.1111/j.1365-2788.2007.01027.x
   Richman DM, 2005, AM J MENT RETARD, V110, P439, DOI 10.1352/0895-8017(2005)110[439:LAOSPA]2.0.CO;2
   Rojahn J, 2012, J INTELL DISABIL RES, V56, P527, DOI 10.1111/j.1365-2788.2011.01507.x
   Rojahn J, 2001, J AUTISM DEV DISORD, V31, P577, DOI 10.1023/A:1013299028321
   Rojahn J, 2013, RES DEV DISABIL, V34, P1804, DOI 10.1016/j.ridd.2013.02.024
   Rojahn J, 2008, ASSESS TREAT CHILD P, V2, P1
   Sameroff A.J., 2009, T MODEL DEV CHILDREN
   Sandman CA, 2012, J INTELL DISABIL RES, V56, P516, DOI 10.1111/j.1365-2788.2012.01552.x
   Schopler E., 1988, CHILD AUTISM RATING
   Schroeder S. R., 1982, AAMD MONOGRAPH SERIE, V5, P105
   Schroeder S. R., 2013, J DEV PHYS DISABIL, V26, P237
   Schroeder S. R., 1970, PSYCHOL REC, V20, P337
   Schroeder S. R., J DEV PHYS DISABILIT, V26, P325
   Schroeder SR, 2008, INT REV RES MENT RET, V36, P195, DOI 10.1016/S0074-7750(08)00006-2
   Schroeder SR, 2012, J MENT HEALTH RES IN, V5, P203, DOI 10.1080/19315864.2011.593697
   SCHROEDER SR, 1980, J AUTISM DEV DISORD, V10, P417, DOI 10.1007/BF02414818
   Symons FJ, 2005, J INTELL DISABIL RES, V49, P144, DOI 10.1111/j.1365-2788.2004.00632.x
   TATE BG, 1966, BEHAV RES THER, V4, P281, DOI 10.1016/0005-7967(66)90024-6
   Taylor L, 2011, J APPL RES INTELLECT, V24, P105, DOI 10.1111/j.1468-3148.2010.00579.x
   Thelen E., 1996, STEREOTYPED MOVEMENT
   THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X
   Usrey K. M., GENETIC ANA IN PRESS
   Wacker DP, 2013, PSYCHOL REC, V63, P3
   Wacker DP, 1998, J DEV BEHAV PEDIATR, V19, P260, DOI 10.1097/00004703-199808000-00004
   Wacker DP, 2011, J EXP ANAL BEHAV, V96, P261, DOI 10.1901/jeab.2011.96-261
   Wetherby AM, 2002, COMMUNICATION SYMBOL
NR 73
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JUL
PY 2014
VL 119
IS 4
BP 351
EP 370
DI 10.1352/1944-7558-119.4.351
PG 20
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AO3XP
UT WOS:000341270900005
PM 25007299
ER

PT J
AU McCullough, E
   Stedmon, J
   Dallos, R
AF McCullough, Elaine
   Stedmon, Jacqui
   Dallos, Rudi
TI Narrative responses as an aid to understanding the presentation of
   maltreated children who meet criteria for autistic spectrum disorder and
   reactive attachment disorder: A case series study
SO CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autistic spectrum disorder; qualitative research; mentalisation; Story
   Stems; attachment; theory of mind
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; FALSE-BELIEF; DIFFICULTIES
   QUESTIONNAIRE; MENTAL-HEALTH; NORMAL ADULTS; RIGHT BRAIN; MIND; EMOTION;
   LANGUAGE
AB This paper offers research case studies of four severely maltreated children who had received a diagnosis of autistic spectrum disorder. A range of measures were employed to explore the children's psychological and emotional functioning, including Theory of Mind assessment (Sally-Anne Test), attachment measures (Story Stems Assessment Profile and Relationship Problems Questionnaire), along with measures to assess general psychological and emotional well-being. Contrary to the diagnosis, the children did not reveal a theory of mind deficit. However, they did indicate a profile of difficulties in mentalisation on the Story Stems. The findings are discussed in terms of the extent to which mentalisation and theory of mind are influenced by situational factors, especially the anxiety evoked by the Story Stem attachment scenarios. Clinical implications regarding mentalisation as a state vs. trait phenomenon are discussed.
C1 [McCullough, Elaine; Stedmon, Jacqui; Dallos, Rudi] Univ Plymouth, Plymouth PL4 8AA, Devon, England.
RP McCullough, E (reprint author), Family Futures, 3 & 4 Floral Pl,7-9 Northampton Grove, London N1 2PL, England.
EM Elaine_McCullough@hotmail.co.uk
CR Ainsworth M. S., 1978, PATTERNS ATTACHMENT
   Auyeung B, 2009, J AUTISM DEV DISORD, V39, P1509, DOI 10.1007/s10803-009-0772-x
   Bailey A, 1996, J CHILD PSYCHOL PSYC, V37, P89, DOI 10.1111/j.1469-7610.1996.tb01381.x
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Baron-Cohen S, 1993, UNDERSTANDING OTHER
   Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
   Baron-Cohen S, 2008, Q J EXP PSYCHOL, V61, P64, DOI 10.1080/17470210701508749
   BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bowlby J., 1973, ATTACHMENT LOSS
   Briere J., 1996, TRAUMA SYMPTOM CHECK
   Cicchetti D, 2003, DEV PSYCHOPATHOL, V15, P1067, DOI 10.1017/S0954579403000440
   Fonagy P, 2007, J CHILD PSYCHOL PSYC, V48, P288, DOI 10.1111/j.1469-7610.2007.01727.x
   Fonagy P., 1991, INFANT MENT HEALTH J, V13, P200, DOI DOI 10.1002/1097-0355
   Fonagy Peter, 2002, AFFECT REGULATION ME
   Gillberg C, 1998, BRIT J PSYCHIAT, V172, P200, DOI 10.1192/bjp.172.3.200
   Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Hill AL, 2006, DEV PSYCHOL, V42, P913, DOI 10.1037/0012-1649.42.5.913
   Hodges J, 2000, J CHILD PSYCHOTHERAP, V26, P433
   Hodges J., 2007, STORY STEM ASSESSMEN
   Hodges J, 2003, CLIN CHILD PSYCHOL P, V8, P351, DOI DOI 10.1037/0022-006X.74.6.1017
   Hodges J., 2005, PSYCHOL ISSUES ADOPT
   Hodges J., 2003, REVEALING INNER WORL, P240
   Liotti G, 2004, PSYCHOTHERAPY, V41, P472, DOI 10.1037/0033-3204.41.4.472
   Main M, 1996, J CONSULT CLIN PSYCH, V64, P237, DOI 10.1037/0022-006X.64.2.237
   Mesulam MM, 1998, BRAIN, V121, P1013, DOI 10.1093/brain/121.6.1013
   Milligan K, 2007, CHILD DEV, V78, P622, DOI 10.1111/j.1467-8624.2007.01018.x
   Minnis H, 2002, INT J METH PSYCH RES, V11, P90, DOI 10.1002/mpr.127
   Minnis H, 2007, BRIT J PSYCHIAT, V190, P490, DOI 10.1192/bjp.bp.105.019745
   Minnis H, 2009, J CHILD PSYCHOL PSYC, V50, P931, DOI 10.1111/j.1469-7610.2009.02075.x
   Mukaddes NM, 2004, AUTISM, V8, P101, DOI 10.1177/1362361304040642
   Music G., 2010, NURTURING NATURES AT
   Pears KC, 2005, DEV PSYCHOPATHOL, V17, P47, DOI 10.1017/S0954579405050030
   Perry B. D., 1997, CHILDREN VIOLENT SOC, P124
   Perry BD, 1995, INFANT MENT HEALTH J, V16, P271, DOI 10.1002/1097-0355(199524)16:4<271::AID-IMHJ2280160404>3.0.CO;2-B
   Pollak SD, 2000, DEV PSYCHOL, V36, P679, DOI 10.1037//0012-1649.36.5.679
   RUTTER M, 1990, J CHILD PSYCHOL PSYC, V31, P39, DOI 10.1111/j.1469-7610.1990.tb02273.x
   Schore AN, 2001, INFANT MENT HEALTH J, V22, P201, DOI 10.1002/1097-0355(200101/04)22:1<201::AID-IMHJ8>3.0.CO;2-9
   Schore AN, 2002, AUST NZ J PSYCHIAT, V36, P9, DOI 10.1046/j.1440-1614.2002.00996.x
   Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008
   Tarren-Sweeney M, 2008, CHILD YOUTH SERV REV, V30, P1, DOI 10.1016/j.childyouth.2007.05.014
   Tarullo AR, 2007, SOC DEV, V16, P57, DOI 10.1111/j.1467-9507.2007.00372.x
   TIBBITSKLEBER AL, 1985, J CLIN CHILD PSYCHOL, V14, P304, DOI 10.1207/s15374424jccp1404_6
   van Ijzendoorn MH, 1996, J CONSULT CLIN PSYCH, V64, P8, DOI 10.1037/0022-006X.64.1.8
   van IJzendoorn MH, 2007, CHILD DEV, V78, P597, DOI 10.1111/j.1467-8624.2007.01016.x
   Watson C. L., 1999, DEV PSYCHOL, V35, P386
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
   Zeanah C., 1987, INFANT MENT HEALTH J, V8, P237, DOI 10.1002/1097-0355(198723)8:3<237::AID-IMHJ2280080307>3.0.CO;2-H
   Zeanah CH, 1996, J CONSULT CLIN PSYCH, V64, P42, DOI 10.1037/0022-006X.64.1.42
   Zeanah CH, 2002, J AM ACAD CHILD PSY, V41, DOI 10.1097/00004583-200208000-00017
NR 53
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1359-1045
EI 1461-7021
J9 CLIN CHILD PSYCHOL P
JI Clin. Child Psychol. Psychiatry
PD JUL
PY 2014
VL 19
IS 3
BP 392
EP 411
DI 10.1177/1359104513503353
PG 20
WC Psychology, Clinical; Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA AO0BS
UT WOS:000340974700006
PM 24121230
ER

PT J
AU Gomez, R
   Corr, PJ
AF Gomez, Rapson
   Corr, Philip J.
TI ADHD and personality: A meta-analytic review
SO CLINICAL PSYCHOLOGY REVIEW
LA English
DT Article
DE Meta-analysis; ADHD; Inattention; Hyperactivity; Personality;
   Five-Factor Model
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
   DISORDER; AUTISM SPECTRUM DISORDERS; LATENT STRUCTURE; KOREAN CHILDREN;
   5-FACTOR MODEL; PATHWAY MODEL; EFFECT SIZE; TEMPERAMENT; CHARACTER
AB We report a meta-analysis of up to 40 data sets that examined the personality dimensions in the Five-Factor Model (FFM) and the integrated Five-Factor Model (IFFM) in relation to ADHD symptom domains of inattention (IA) and hyperactivity/impulsivity (HI). The IFFM incorporated the dimensions of other personality models (in particular, those of Eysenck, Tellegen, and Cloninger, as well as the FFM). Major findings were: (1) IA and HI were both associated with low conscientious inhibition/conscientiousness, and low agreeable inhibition/agreeableness, and with high negative emotionality/neurotidsm; (2) conscientious inhibition and conscientiousness were more strongly related to IA than HI; (3) agreeable inhibition and agreeableness were more strongly related to HI than IA; and (4) the association of conscientious inhibition and conscientiousness with HI was moderated by age group and source from where participants were recruited (associations were stronger in children than adults, and clinical samples than community samples). These findings are discussed in relation to single and multiple pathway theories, underlying factors and processes for the personality-ADHD link, and clinical implications. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Gomez, Rapson] Federat Univ, Ballarat, Vic 3353, Australia.
   [Corr, Philip J.] City Univ London, London, England.
RP Gomez, R (reprint author), Federat Univ, Sch Hlth Sci, POB 663, Ballarat, Vic 3353, Australia.
EM rapson.gomez@federation.edu.au
CR Achenbach T. M., 2001, MANUAL ASEBA SCHOOLA
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Anckarsater H, 2006, AM J PSYCHIAT, V163, P1239, DOI 10.1176/appi.ajp.163.7.1239
   Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
   Bettencourt BA, 1996, PSYCHOL BULL, V119, P422, DOI 10.1037/0033-2909.119.3.422
   Biederman J., 1993, AM J PSYCHIAT, V150, P1992
   Biederman J, 2005, BIOL PSYCHIAT, V57, P1215, DOI 10.1016/j.biopsych.2004.10.020
   Borenstein M., 2007, COMPREHENSIVE METAAN
   Borenstein M, 2009, INTRO METAANALYSIS
   Braaten EB, 1997, PERS INDIV DIFFER, V22, P355, DOI 10.1016/S0191-8869(96)00217-6
   Caspi A., 1992, PSYCHOL ASSESSMENT, V4, P512, DOI 10.1037/1040-3590.4.4.512
   Cho SC, 2008, PSYCHIAT CLIN NEUROS, V62, P160, DOI 10.1111/j.1440-1819.2008.01749.x
   Cho SC, 2009, EUR CHILD ADOLES PSY, V18, P447, DOI 10.1007/s00787-009-0755-7
   CLONINGER CR, 1987, ARCH GEN PSYCHIAT, V44, P573
   CLONINGER CR, 1993, ARCH GEN PSYCHIAT, V50, P975
   Coghill D, 2012, J CHILD PSYCHOL PSYC, V53, P469, DOI 10.1111/j.1469-7610.2011.02511.x
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Costa P. T., 1992, REVISED NEO PERSONAL
   Costa P.T., 1985, NEO PERSONALITY INVE
   COSTA PT, 1988, J PERS SOC PSYCHOL, V54, P853, DOI 10.1037//0022-3514.54.5.853
   Cukrowicz KC, 2006, J CHILD PSYCHOL PSYC, V47, P151, DOI 10.1111/j.1469-7610.2005.01461.x
   De Pauw S. S. W., 2010, J ABNORMAL CHILD PSY, V39, P277
   Downey KK, 1996, J SUBST ABUSE, V8, P129, DOI 10.1016/S0899-3289(96)90139-X
   Downey KK, 1997, J NERV MENT DIS, V185, P32, DOI 10.1097/00005053-199701000-00006
   Eysenck H. J., 1994, MANUAL EYSENCK PERSO
   Eysenck H. J., 1975, MANUAL EYSENCK PERSO
   Eysenck MW, 2007, EMOTION, V7, P336, DOI 10.1037/1528-3542.7.2.336
   EYSENCK MW, 1992, COGNITION EMOTION, V6, P409, DOI 10.1080/02699939208409696
   Faraone A. V., 2009, PSYCHOL MED, V39, P685
   Faraone A. V., 2001, CHILD ADOL PSYCH CL, V10, P299
   Fern EF, 1996, J CONSUM RES, V23, P89, DOI 10.1086/209469
   Field AP, 2001, PSYCHOL METHODS, V6, P161, DOI 10.1037//1082-989X.6.2.161
   GOLDBERG LR, 1993, AM PSYCHOL, V48, P26, DOI 10.1037//0003-066X.48.1.26
   Gomez Rapson, 2007, J Atten Disord, V11, P17, DOI 10.1177/1087054706295665
   Gomez R, 2012, PERS INDIV DIFFER, V52, P290, DOI 10.1016/j.paid.2011.10.015
   Gomez R, 2009, CAMBRIDGE HANDBOOK OF PERSONALITY PSYCHOLOGY, P704
   Gomez R, 2010, PERS INDIV DIFFER, V49, P902, DOI 10.1016/j.paid.2010.06.033
   Gray J. A, 1975, ELEMENTS 2 PROCESS T
   Gray J.A., 1982, NEUROPSYCHOLOGY ANXI
   Gudjonsson GH, 2009, PERS INDIV DIFFER, V47, P64, DOI 10.1016/j.paid.2009.01.048
   Hafdahl AR, 2009, PSYCHOL METHODS, V14, P24, DOI 10.1037/a0014697
   Hedges L V., 1998, HDB RES SYNTHESIS
   Hedges LV, 1996, J EDUC BEHAV STAT, V21, P299, DOI 10.3102/10769986021004299
   Higgins JPT, 2003, BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186
   HUFFCUTT AI, 1995, J APPL PSYCHOL, V80, P327, DOI 10.1037/0021-9010.80.2.327
   Hundt NE, 2008, PERS INDIV DIFFER, V44, P565, DOI 10.1016/j.paid.2007.09.018
   Jacob CP, 2007, EUR ARCH PSY CLIN N, V257, P309, DOI 10.1007/s00406-007-0722-6
   JOHN OP, 1994, CHILD DEV, V65, P160, DOI 10.1111/j.1467-8624.1994.tb00742.x
   Kessler RC, 2005, BIOL PSYCHIAT, V57, P1442, DOI 10.1016/j.biopsych.2005.04.001
   Lahey BB, 2010, J CLIN CHILD ADOLESC, V39, P761, DOI 10.1080/15374416.2010.517173
   Lipsey M. W., 2000, PRACTICAL METAANALYS, V49
   Luby JL, 1999, PSYCHOL REP, V84, P1127, DOI 10.2466/PR0.84.3.1127-1138
   Luman M, 2012, J ABNORM CHILD PSYCH, V40, P145, DOI 10.1007/s10802-011-9547-x
   Lynn DE, 2005, AM J PSYCHIAT, V162, P906, DOI 10.1176/appi.ajp.162.5.906
   Marcus DK, 2011, J ABNORM PSYCHOL, V120, P427, DOI 10.1037/a0021405
   Markon KE, 2005, J PERS SOC PSYCHOL, V88, P139, DOI 10.1037/0022-3514.88.1.139
   Martel MM, 2010, J ABNORM PSYCHOL, V119, P186, DOI 10.1037/a0017511
   Martel MM, 2006, J CHILD PSYCHOL PSYC, V47, P1175, DOI 10.1111/j.1469-7610.2006.01629.x
   Martel MM, 2009, J ABNORM CHILD PSYCH, V37, P337, DOI 10.1007/s10802-008-9255-3
   Martel MM, 2010, J CHILD PSYCHOL PSYC, V51, P905, DOI 10.1111/j.1469-7610.2010.02232.x
   Martel MM, 2008, J RES PERS, V42, P895, DOI 10.1016/j.jrp.2007.12.004
   Martel MM, 2011, J ABNORM CHILD PSYCH, V39, P1111, DOI 10.1007/s10802-011-9538-y
   McCrae RR, 2005, J PERS SOC PSYCHOL, V88, P547, DOI 10.1037/0022-3514.88.3.547
   Mervielde I, 2002, BIG FIVE ASSESSMENT, P129
   Miller CJ, 2008, J ABNORM CHILD PSYCH, V36, P165, DOI 10.1007/s10802-007-9167-7
   Nigg JT, 2010, CURR DIR PSYCHOL SCI, V19, P24, DOI 10.1177/0963721409359282
   Nigg JT, 2004, J CLIN CHILD ADOLESC, V33, P42, DOI 10.1207/S15374424JCCP3301_5
   Nigg JT, 2006, J CHILD PSYCHOL PSYC, V47, P395, DOI 10.1111/j.1469-7610.2006.01612.x
   Nigg JT, 2002, J PERS SOC PSYCHOL, V83, P451, DOI 10.1037//0022-3514.83.2.451
   Parker JDA, 2004, PERS INDIV DIFFER, V36, P977, DOI 10.1016/S0191-8869(03)00166-1
   Purper-Ouakil D, 2010, COMPR PSYCHIAT, V51, P286, DOI 10.1016/j.comppsych.2009.08.004
   Ranseen JD, 1998, ASSESSMENT, V5, P19, DOI 10.1177/107319119800500104
   Rettew DC, 2004, J DEV BEHAV PEDIATR, V25, P383, DOI 10.1097/00004703-200412000-00001
   Retz W, 2004, EUR ARCH PSY CLIN N, V254, P201, DOI 10.1007/s00406-004-0470-9
   Rosler M., 2004, DIAGNOSIS ATTENTION
   Salgado CAI, 2009, PSYCHOPATHOLOGY, V42, P108, DOI 10.1159/000203343
   Sizoo B, 2009, J NERV MENT DIS, V197, P450, DOI 10.1097/NMD.0b013e3181a61dd0
   Smalley SL, 2009, J CLIN PSYCHOL, V65, P1087, DOI 10.1002/jclp.20618
   Sonuga-Barke EJS, 2005, BIOL PSYCHIAT, V57, P1231, DOI 10.1016/j.biopsych.2004.09.008
   Sonuga-Barke EJS, 2003, NEUROSCI BIOBEHAV R, V27, P593, DOI 10.1016/j.neubiorev.2003.08.005
   SONUGABARKE EJS, 1992, J CHILD PSYCHOL PSYC, V33, P387, DOI 10.1111/j.1469-7610.1992.tb00874.x
   Spencer T, 1999, PEDIATR CLIN N AM, V46, P915, DOI 10.1016/S0031-3955(05)70163-2
   Tackett JL, 2006, CLIN PSYCHOL REV, V26, P584, DOI 10.1016/j.cpr.2006.04.003
   Tellegen A., 2000, MANUAL MULTIDIMENSIO
   Tillman R, 2003, J CHILD ADOL PSYCHOP, V13, P531, DOI 10.1089/104454603322724922
   Toplak ME, 2009, J ABNORM CHILD PSYCH, V37, P1137, DOI 10.1007/s10802-009-9336-y
   Van Leeuwen KG, 2007, EUR J PERSONALITY, V21, P63, DOI 10.1002/per.598
   Weinstein CS, 1998, PSYCHIATRY, V61, P12
   Willcutt EG, 2012, J ABNORM PSYCHOL, V121, P991, DOI 10.1037/a0027347
   Yoo HJ, 2006, PSYCHOPATHOLOGY, V39, P25, DOI 10.1159/000089660
NR 94
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0272-7358
EI 1873-7811
J9 CLIN PSYCHOL REV
JI Clin. Psychol. Rev.
PD JUL
PY 2014
VL 34
IS 5
BP 376
EP 388
DI 10.1016/j.cpr.2014.05.002
PG 13
WC Psychology, Clinical
SC Psychology
GA AO1JD
UT WOS:000341067500002
PM 24929793
ER

PT J
AU Kothare, SV
   Singh, K
   Hochman, T
   Chalifoux, JR
   Staley, BA
   Weiner, HL
   Menzer, K
   Devinsky, O
AF Kothare, Sanjeev V.
   Singh, Kanwaljit
   Hochman, Tsivia
   Chalifoux, Jason R.
   Staley, Brigid A.
   Weiner, Howard L.
   Menzer, Kimberly
   Devinsky, Orrin
TI Genotype/phenotype in tuberous sclerosis complex: Associations with
   clinical and radiologic manifestations
SO EPILEPSIA
LA English
DT Article
DE Tuberous sclerosis complex; Epilepsy; Autism spectrum disorders
ID AUTISM SPECTRUM DISORDERS; GIANT-CELL TUMORS; CHILDREN; EPILEPSY
AB Objectives: Patients with tuberous sclerosis complex (TSC) frequently have autism spectrum disorders and neuropsychiatric disorders. Subependymal giant cell astrocytomas (SEGAs) have been reported to occur in 5-20% of patients with TSC; however, the relationship between SEGAs and neuropsychiatric disorders in TSC remains unknown. We utilized a large multicenter database to study associations between SEGAs and neuropsychiatric disorders in patients with TSC.
   Methods: Associations between the presence of SEGAs and neuropsychiatric disorders were examined in a retrospective review of 916 patients enrolled in the TSC Natural History Database Project (Tuberous Sclerosis Alliance).
   Results: Among the 916 TSC patients, 226 had SEGAs (25%) and 155 had autism spectrum disorder (ASD) (17%). Compared to patients without SEGAs, patients with SEGAs were 1.83 (95% confidence interval [CI] 1.26-2.66) times more likely to have ASD. No significant relationship was found between SEGAs and intellectual disability, attention-deficit/hyperactive disorder, or major depressive disorder.
   Significance: The clinical presentation of TSC is highly variable and not well understood. These data show that SEGAs are associated with ASD in patients with TSC, suggesting that the pathologic changes leading to SEGA formation may also predispose patients to ASD.
C1 [Kothare, Sanjeev V.; Chalifoux, Jason R.; Weiner, Howard L.; Menzer, Kimberly; Devinsky, Orrin] NYU, Dept Neurol, Langone Med Ctr, Comprehens Epilepsy Ctr, New York, NY 10016 USA.
   [Singh, Kanwaljit] Harvard Univ, Childrens Hosp, Sch Med, Div Clin Neurophysiol,Dept Neurol, Boston, MA 02115 USA.
   [Singh, Kanwaljit] Harvard Univ, Sch Med, Massachusetts Gen Hosp Children, Lurie Ctr, Boston, MA USA.
   [Hochman, Tsivia] NYU, Langone Med Ctr, Div Biostat, New York, NY USA.
   [Staley, Brigid A.; Weiner, Howard L.] NYU, Dept Neurosurg, Langone Med Ctr, New York, NY 10016 USA.
RP Kothare, SV (reprint author), NYU, Dept Neurol, Langone Med Ctr, Comprehens Epilepsy Ctr, New York, NY 10016 USA.
EM sanjeev.kothare@nyumc.org
CR Adriaensen MEAPM, 2009, EUR J NEUROL, V16, P691, DOI 10.1111/j.1468-1331.2009.02567.x
   Asano E, 2001, NEUROLOGY, V57, P1269
   Baio J, 2012, PREVALENCE AUTISM SP, V14
   Bolton PF, 2002, BRAIN, V125, P1247, DOI 10.1093/brain/awf124
   Bolton PF, 1997, LANCET, V349, P392, DOI 10.1016/S0140-6736(97)80012-8
   Chu-Shore CJ, 2009, NEUROLOGY, V72, P1165, DOI 10.1212/01.wnl.0000345365.92821.86
   Chu-Shore CJ, 2010, EPILEPSIA, V51, P1236, DOI 10.1111/j.1528-1167.2009.02474.x
   Crino PB, 2006, NEW ENGL J MED, V355, P1345, DOI 10.1056/NEJMra055323
   de Vries PJ, 2007, EUR CHILD ADOLES PSY, V16, P16, DOI 10.1007/s00787-006-0570-3
   Eluvathingal TJ, 2006, J CHILD NEUROL, V21, P846, DOI 10.2310/7010.2006.00192
   Goh S, 2004, NEUROLOGY, V63, P1457
   Goh S, 2005, NEUROLOGY, V65, P235, DOI 10.1212/01.wnl.0000168908.78118.99
   Holmes GL, 2006, EPILEPSY BEHAV, V8, P504, DOI 10.1016/j.yebeh.2005.11.014
   ILAE, 1989, EPILEPSIA, V30, P389
   Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
   Khan S, 2013, P NATL ACAD SCI USA, V110, P3107, DOI 10.1073/pnas.1214533110
   BANCAUD J, 1981, EPILEPSIA, V22, P489
   Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
   Webb DW, 1996, DEV MED CHILD NEUROL, V38, P146
   Wong V, 2006, J CHILD NEUROL, V21, P199, DOI 10.2310/7010.2006.00046
   Zhou JL, 2007, EPILEPSIA, V48, P720, DOI 10.1111/j.1528-1167.2006.00972.x
NR 21
TC 0
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
EI 1528-1167
J9 EPILEPSIA
JI Epilepsia
PD JUL
PY 2014
VL 55
IS 7
BP 1020
EP 1024
DI 10.1111/epi.12627
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA AN4YI
UT WOS:000340595500015
PM 24754401
ER

PT J
AU Kothare, SV
   Singh, K
   Chalifoux, JR
   Staley, BA
   Weiner, HL
   Menzer, K
   Devinsky, O
AF Kothare, Sanjeev V.
   Singh, Kanwaljit
   Chalifoux, Jason R.
   Staley, Brigid A.
   Weiner, Howard L.
   Menzer, Kimberly
   Devinsky, Orrin
TI Severity of manifestations in tuberous sclerosis complex in relation to
   genotype
SO EPILEPSIA
LA English
DT Article
DE Tuberous sclerosis complex; Epilepsy; TSC mutations
ID AUTISM SPECTRUM DISORDERS; GENE-PRODUCTS; TSC2 GENE; EPILEPSY; HAMARTIN;
   MUTATIONS
AB Objective: Patients with tuberous sclerosis complex (TSC) commonly present with significant neurologic deficits, including seizures, autism, and intellectual disability. Previous evidence suggests that the TSC2 mutation genotype may be associated with a more severe disease phenotype. This study evaluates the association of the TSC1 and TSC2 genotype with patient and disease characteristics in a retrospective review of a large TSC Natural History Database consisting of 919 patients with TSC.
   Methods: Univariate logistic regression was conducted to evaluate the association of the TSC1 and TSC2 gene mutations with patient and disease characteristics.
   Results: As compared to patients with the TSC1 mutation, patients with the TSC2 mutation were younger (p = 0.02), more likely to have partial epilepsy (odds ratio (OR) 1.74, p = 0.0015), complex partial seizures (OR 2.03, p = 0.02), infantile spasms (IS) (OR 1.67, p = 0.01), subependymal giant-cell astrocytomas (SEGAs) (OR 1.64, p = 0.01), and intellectual disability (OR 2.90, p = 0.0002).
   Significance: The clinical presentation of TSC is highly variable and not well understood. Our findings confirm and supplement existing literature that TSC2 mutation is likely to be associated with a more severe, earlier presenting TSC phenotype, including infantile spasms.
C1 [Kothare, Sanjeev V.; Singh, Kanwaljit; Chalifoux, Jason R.; Weiner, Howard L.; Menzer, Kimberly; Devinsky, Orrin] NYU, Dept Neurol, Langone Med Ctr, Comprehens Epilepsy Ctr, New York, NY 10016 USA.
   [Singh, Kanwaljit] Univ Massachusetts, Sch Med, Dept Pediat Neurol, Worcester, MA USA.
   [Staley, Brigid A.; Weiner, Howard L.] NYU, Dept Neurosurg, Langone Med Ctr, New York, NY 10016 USA.
RP Kothare, SV (reprint author), NYU, Dept Neurol, Langone Med Ctr, Comprehens Epilepsy Ctr, New York, NY 10016 USA.
EM Sanjeev.Kothare@nyumc.org
CR Au Kit Sing, 2007, Genet Med, V9, P88, DOI 10.1097/GIM.0b013e31803068c7
   Berg AT, 2012, EPILEPSY BEHAV, V23, P193, DOI 10.1016/j.yebeh.2012.01.015
   Chu-Shore CJ, 2010, EPILEPSIA, V51, P1236, DOI 10.1111/j.1528-1167.2009.02474.x
   Crino PB, 2006, NEW ENGL J MED, V355, P1345, DOI 10.1056/NEJMra055323
   Dabora SL, 2001, AM J HUM GENET, V68, P64, DOI 10.1086/316951
   Goh S, 2005, NEUROLOGY, V65, P235, DOI 10.1212/01.wnl.0000168908.78118.99
   Gutmann DH, 2000, ACTA NEUROPATHOL, V99, P223
   ILAE, 1989, EPILEPSIA, V30, P389
   Jansen FE, 2008, NEUROLOGY, V70, P908, DOI 10.1212/01.wnl.0000280578.99900.96
   Jones AC, 1997, HUM MOL GENET, V6, P2155, DOI 10.1093/hmg/6.12.2155
   BANCAUD J, 1981, EPILEPSIA, V22, P489
   Maheshwar MM, 1997, HUM MOL GENET, V6, P1991, DOI 10.1093/hmg/6.11.1991
   Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
   Plank TL, 1998, CANCER RES, V58, P4766
   Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
   Tuchman R, 2010, BRAIN DEV-JPN, V32, P709, DOI 10.1016/j.braindev.2010.04.008
   van Slegtenhorst M, 1998, HUM MOL GENET, V7, P1053, DOI 10.1093/hmg/7.6.1053
   Webb DW, 1996, DEV MED CHILD NEUROL, V38, P146
   Wong V, 2006, J CHILD NEUROL, V21, P199, DOI 10.2310/7010.2006.00046
   Wu WE, 2013, EPILEPSY BEHAV, V27, P319, DOI 10.1016/j.yebeh.2013.02.018
NR 20
TC 1
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
EI 1528-1167
J9 EPILEPSIA
JI Epilepsia
PD JUL
PY 2014
VL 55
IS 7
BP 1025
EP 1029
DI 10.1111/epi.12680
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA AN4YI
UT WOS:000340595500016
PM 24917535
ER

PT J
AU Greenslade, KJ
   Coggins, TE
AF Greenslade, Kathryn J.
   Coggins, Truman E.
TI Assessing young children's intention-reading in authentic communicative
   contexts: preliminary evidence and clinical utility
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE assessment; children; intention-reading; social communication
ID JOINT ATTENTION; AUTISM; RELIABILITY; MIND; AGE; INVENTORY; LANGUAGE;
   INFANCY
AB Background: Identifying what a communication partner is looking at (referential intention) and why (social intention) is essential to successful social communication, and may be challenging for children with social communication deficits. This study explores a clinical task that assesses these intention-reading abilities within an authentic context.
   Aims: To gather evidence of the task's reliability and validity, and to discuss its clinical utility.
   Methods & Procedures: The intention-reading task was administered to twenty 4-7-year-olds with typical development (TD) and ten with autism spectrum disorder (ASD). Task items were embedded in an authentic activity, and they targeted the child's ability to identify the examiner's referential and social intentions, which were communicated through joint attention behaviours. Reliability and construct validity evidence were addressed using established psychometric methods.
   Outcomes & Results: Reliability and validity evidence supported the use of task scores for identifying children whose intention-reading warranted concern. Evidence supported the reliability of task administration and coding, and item-level codes were highly consistent with overall task performance. Supporting task validity, group differences aligned with predictions, with children with ASD exhibiting poorer and more variable task scores than children with TD. Also, as predicted, task scores correlated significantly with verbal mental age and ratings of parental concerns regarding social communication abilities.
   Conclusions & Implications: The evidence provides preliminary support for the reliability and validity of the clinical task's scores in assessing young children's real-time intention-reading abilities, which are essential for successful interactions in school and beyond.
C1 [Greenslade, Kathryn J.; Coggins, Truman E.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA.
RP Greenslade, KJ (reprint author), Univ Washington, Dept Speech & Hearing Sci, Eagleson Hall,1417 NE 42nd St,Box 354875, Seattle, WA 98105 USA.
EM greenskj@uw.edu
FU National Institutes of Health [T32DC000033]
FX The first author was supported by a National Institutes of Health
   training grant (Research Training Program in Speech and Hearing
   Sciences: T32DC000033) while conducting the present research. The
   authors thank the reviewers for their thoughtful contributions to
   revisions of this paper. They also acknowledge their colleagues, Lesley
   B. Olswang, PamelaCrooke, Julie Feuerstein and Amy Rodda, for cogent
   comments. Declaration of interest: The authors report no conflicts of
   interest. The authors alone are responsible for the content and writing
   of the paper.
CR Allen M., 1979, INTRO MEASUREMENT TH
   American Psychiatric Association, 2013, DIAGN STAT MAN, V5th
   American Speech-Language-Hearing Association, 2006, GUID SPEECH LANG PAT
   BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
   BILLINGSLEY F, 1980, BEHAV ASSESS, V2, P229
   Bishop D. V., 2006, CHILDRENS COMMUNICAT
   Carrow-Woolfolk E., 1999, TEST AUDITORY COMPRE
   Charman T, 2000, COGNITIVE DEV, V15, P481, DOI 10.1016/S0885-2014(01)00037-5
   CICCHETTI DV, 1981, AM J MENT DEF, V86, P127
   COGGINS TE, 1981, APPL PSYCHOLINGUIST, V2, P235, DOI 10.1017/S0142716400006536
   Garcia Winner M., 2007, THINKING YOU THINKIN, V2nd
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   HARTMANN DP, 1977, J APPL BEHAV ANAL, V10, P103, DOI 10.1901/jaba.1977.10-103
   Hutchins TL, 2012, J AUTISM DEV DISORD, V42, P327, DOI 10.1007/s10803-011-1244-7
   Kaufman A. S., 2004, KAUFMAN BRIEF INTELL
   Liebal K, 2009, DEVELOPMENTAL SCI, V12, P264, DOI 10.1111/j.1467-7687.2008.00758.x
   MELTZOFF A. N., 2009, INFANT PATHWAYS LANG, P169
   Messick S., 1989, ED MEASUREMENT, P13
   Messick S., 1989, EDUC RES, V18, P5, DOI DOI 10.3102/0013189X018002005
   Miller J., 2002, SYSTEMATIC ANAL LANG
   Moll H, 2008, INFANCY, V13, P90, DOI 10.1080/15250000701779402
   Moll H, 2006, BRIT J DEV PSYCHOL, V24, P603, DOI 10.1348/026151005X55370
   Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
   Olswang LB, 2001, TOP LANG DISORD, V22, P50
   Russell RL, 2008, CLIN CHILD FAM PSYCH, V11, P59, DOI 10.1007/s10567-008-0032-1
   Schertz HH, 2013, EARLY CHILD RES Q, V28, P249, DOI 10.1016/j.ecresq.2012.06.006
   Semel E., 2003, CLIN EVALUATION LANG, V4th
   Sperber D., 1986, RELEVANCE COMMUNICAT
   Timler GR, 2005, LANG SPEECH HEAR SER, V36, P73, DOI 10.1044/0161-1461(2005/007)
   Tomasello M., 2008, ORIGINS HUMAN COMMUN
   Tomasello M, 2003, DEV PSYCHOL, V39, P906, DOI 10.1037/0012-1649.39.5.906
   Vermeulen P., 2012, AUTISM CONTEXT BLIND
   Wiig E. H., 2004, CLIN EVALUATION LANG
NR 33
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-2822
EI 1460-6984
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD JUL-AUG
PY 2014
VL 49
IS 4
BP 463
EP 477
DI 10.1111/1460-6984.12076
PG 15
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AN4ZW
UT WOS:000340599700005
PM 24684559
ER

PT J
AU Lerna, A
   Esposito, D
   Conson, M
   Massagli, A
AF Lerna, Anna
   Esposito, Dalila
   Conson, Massimiliano
   Massagli, Angelo
TI Long-term effects of PECS on social-communicative skills of children
   with autism spectrum disorders: a follow-up study
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE Picture Exchange Communication System (PECS); autism spectrum disorders;
   long-term effects; social and communicative skills
ID RANDOMIZED CONTROLLED-TRIAL; JOINT ATTENTION; SYSTEM PECS;
   YOUNG-CHILDREN; INTERVENTION; PREDICTORS; PRESCHOOLERS; INDIVIDUALS;
   ACQUISITION; IMITATION
AB Background: The Picture Exchange Communication System (PECS) is a popular augmentative communication system frequently used with 'nonverbal' children with autism. Several studies suggested that PECS could represent an effective tool for promoting improvement of several social-communicative skills. Only sparse evidence is instead available on the long-term effectiveness of this treatment system.
   Aims: To test the long-term effects of PECS, for which a follow-up study was conducted by assessing social-communicative skills in nonverbal preschool children with autism after 12 months from treatment completion.
   Methods & Procedures: Two groups of children (N = 14) were assessed; one group had completed the PECS training and the other conventional language therapy (CLT). At follow-up all children received the same pre- and post-treatment assessment. Outcome measures were the following: Communication and Social domains of Autism Diagnostic Observation Schedule (ADOS); Language and Personal-Social subscales of the Griffiths' Mental Developmental Scales (GMDS); Communication and Social Abilities domains of the Vineland Adaptive Behavior Scales (VABS); and several social-communicative variables coded in an unstructured setting.
   Outcomes & Results: The PECS group showed significant improvements compared with the CLT group on ADOS severity scores (Communication, Social and Total), on GMDS Social domain and on VABS Communication and Social domains. PECS-related gains on the VABS Social domain and on specific social-communicative measures coded during free-play, i.e. frequency of joint attention and initiation, and duration of cooperative play, were stable after 1-year follow-up. Cooperative play continued to improve on follow-up with respect to both post-and pre-treatment assessment.
   Conclusions & Implications: These findings demonstrated that PECS training can promote long-term enhancement of specific socio-communicative skills in children with autism.
C1 [Lerna, Anna; Esposito, Dalila; Massagli, Angelo] IRCCS Eugenio Medea, Child Psychopathol Unit, Inst Sci, Ostuni, Brindisi, Italy.
   [Conson, Massimiliano] Univ Naples 2, Dept Psychol, Neuropsychol Lab, Caserta, Italy.
RP Massagli, A (reprint author), IRCCS Eugenio Medea, Child Psychopathol Unit, Dept Neurorehabil 2, Inst Sci, Ostuni, Brindisi, Italy.
EM angelo.massagli@irccs.os.lnf.it
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Boesch MC, 2013, AUGMENT ALTERN COMM, V29, P197, DOI 10.3109/07434618.2013.818059
   BONDY A. S., 1994, PECS PICTURE EXCHANG
   Bondy Andrew S., 1998, Seminars in Speech and Language, V19, P373, DOI 10.1055/s-2008-1064055
   Bono MA, 2004, J AUTISM DEV DISORD, V34, P495, DOI 10.1007/s10803-004-2545-x
   Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213
   Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
   Greenspan S. I., 1998, CHILD SPECIAL NEEDS
   Griffiths R., 1984, GRIFFITHS MENTAL DEV
   Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
   Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
   Howlin P, 1997, AUTISM, V1, P135, DOI DOI 10.1177/1362361397012003
   Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
   Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Koegel RL, 2001, J CLIN CHILD PSYCHOL, V30, P19, DOI 10.1207/S15374424JCCP3001_4
   Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
   Lerna A, 2012, INT J LANG COMM DIS, V47, P609, DOI 10.1111/j.1460-6984.2012.00172.x
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lovaas O. I., 1981, TEACHING DEV DISABLE
   LOVAAS O. I., 2002, TEACHING INDIVIDUALS
   Malandraki G.A., 2007, FOCUS AUTISM OTHER D, V22, P23, DOI DOI 10.1177/10883576070220010301
   Mesibov G., 2004, TEACCH APPROACH AUTI
   Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61
   MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
   Preston D, 2009, J AUTISM DEV DISORD, V39, P1471, DOI 10.1007/s10803-009-0763-y
   Rogers SJ, 2010, EARLY START DENVER M
   Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
   Schuler A. L., 1997, HDB AUTISM PERVASIVE, P539
   SIGMAN M., 1999, MONOGRAPHS SOC RES C
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Szatmari P, 2003, J CHILD PSYCHOL PSYC, V44, P520, DOI 10.1111/1469-7610.00141
   Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
   WATSON L. R., 1989, TEACHING SPONTANEOUS
   Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
   YAMAMOTO J., 2006, JAPANESE J SPECIAL E, V43, P485
   Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
   Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
NR 39
TC 0
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-2822
EI 1460-6984
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD JUL-AUG
PY 2014
VL 49
IS 4
BP 478
EP 485
DI 10.1111/1460-6984.12079
PG 8
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AN4ZW
UT WOS:000340599700006
PM 24655345
ER

PT J
AU Loukusa, S
   Makinen, L
   Kuusikko-Gauffin, S
   Ebeling, H
   Moilanen, I
AF Loukusa, Soile
   Makinen, Leena
   Kuusikko-Gauffin, Sanna
   Ebeling, Hanna
   Moilanen, Irma
TI Theory of mind and emotion recognition skills in children with specific
   language impairment, autism spectrum disorder and typical development:
   group differences and connection to knowledge of grammatical morphology,
   word-finding abilities and verbal working memory
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE specific language impairment; autism spectrum disorder; theory of mind;
   emotion recognition
ID UNDERSTANDING EMOTIONS; ASPERGER-SYNDROME; COMPREHENSION; INDIVIDUALS;
   CONTEXT; AGE
AB Background: Social perception skills, such as understanding the mind and emotions of others, affect children's communication abilities in real-life situations. In addition to autism spectrum disorder (ASD), there is increasing knowledge that children with specific language impairment (SLI) also demonstrate difficulties in their social perception abilities.
   Aims: To compare the performance of children with SLI, ASD and typical development (TD) in social perception tasks measuring Theory of Mind (ToM) and emotion recognition. In addition, to evaluate the association between social perception tasks and language tests measuring word-finding abilities, knowledge of grammatical morphology and verbal working memory.
   Method & Procedures: Children with SLI (n = 18), ASD (n = 14) and TD (n = 25) completed two NEPSY-II subtests measuring social perception abilities: (1) Affect Recognition and (2) ToM (includes Verbal and non-verbal Contextual tasks). In addition, children's word-finding abilities were measured with the TWF-2, grammatical morphology by using the Grammatical Closure subtest of ITPA, and verbal working memory by using subtests of Sentence Repetition or Word List Interference (chosen according the child's age) of the NEPSY-II.
   Outcomes & Results: Children with ASD scored significantly lower than children with SLI or TD on the NEPSY-II Affect Recognition subtest. Both SLI and ASD groups scored significantly lower than TD children on Verbal tasks of the ToM subtest of NEPSY-II. However, there were no significant group differences on non-verbal Contextual tasks of the ToM subtest of the NEPSY-II. Verbal tasks of the ToM subtest were correlated with the Grammatical Closure subtest and TWF-2 in children with SLI. In children with ASD correlation between TWF-2 and ToM: Verbal tasks was moderate, almost achieving statistical significance, but no other correlations were found.
   Conclusions & Implications: Both SLI and ASD groups showed difficulties in tasks measuring verbal ToM but differences were not found in tasks measuring non-verbal Contextual ToM. The association between Verbal ToM tasks and language tests was stronger in children with SLI than in children with ASD. There is a need for further studies in order to understand interaction between different areas of language and cognitive development.
C1 [Loukusa, Soile; Makinen, Leena] Univ Oulu, Fac Humanities, Child Language Res Ctr, FIN-90014 Oulu, Finland.
   [Kuusikko-Gauffin, Sanna; Ebeling, Hanna; Moilanen, Irma] Univ Oulu, Fac Med, Inst Clin Med, Dept Child Psychiat, FIN-90014 Oulu, Finland.
   [Kuusikko-Gauffin, Sanna; Ebeling, Hanna; Moilanen, Irma] Univ Hosp Oulu, Oulu, Finland.
RP Loukusa, S (reprint author), Univ Oulu, Fac Humanities, Child Language Res Ctr, POB 1000, FIN-90014 Oulu, Finland.
EM soile.loukusa@oulu.fi
FU Academy of Finland; Alma and K. A. Snellman Foundation, Oulu, Finland
FX The authors are grateful to the children and their parents who
   participated in this study. This research was financially supported by
   the Academy of Finland and the Alma and K. A. Snellman Foundation, Oulu,
   Finland. Declaration of interest: The authors report no conflicts of
   interest. The authors alone are responsible for the content and writing
   of the paper.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
   BARONCOHEN S, 1991, CHILD DEV, V62, P385, DOI 10.1111/j.1467-8624.1991.tb01539.x
   Bishop DVM, 2010, BEHAV GENET, V40, P618, DOI 10.1007/s10519-010-9381-x
   Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082
   Clegg J, 2005, J CHILD PSYCHOL PSYC, V46, P128, DOI 10.1111/j.1469-7610.2004.00342.x
   Colle L, 2007, J AUTISM DEV DISORD, V37, P716, DOI 10.1007/s10803-006-0198-7
   Conti-Ramsden G, 2004, J SPEECH LANG HEAR R, V47, P145, DOI 10.1044/1092-4388(2004/013)
   Farrar MJ, 2009, J COMMUN DISORD, V42, P428, DOI 10.1016/j.jcomdis.2009.07.001
   Ford JA, 2003, J SPEECH LANG HEAR R, V46, P21, DOI 10.1044/1092-4388(2003/002)
   German D. J., 2000, TEST WORD FINDING
   Gillott A., 2004, CHILD LANG TEACH THE, V20, P1, DOI [10.1191/0265659004ct260oa, DOI 10.1191/0265659004CT260OA]
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Kirk S. A., 1968, ILLINOIS TEST PSYCHO
   Korkman M, 2008, NEPSY 2 LASTEN NEURO
   Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
   Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43
   Loucas T, 2008, J CHILD PSYCHOL PSYC, V49, P1184, DOI 10.1111/j.1469-7610.2008.01951.x
   Loukusa S, 2009, RES AUTISM SPECT DIS, V3, P890, DOI 10.1016/j.rasd.2009.05.002
   Loukusa S, 2007, J AUTISM DEV DISORD, V37, P1049, DOI 10.1007/s10803-006-0247-2
   Martin I, 2004, J AUTISM DEV DISORD, V34, P311, DOI 10.1023/B:JADD.0000029553.52889.15
   Messer D, 2013, FIRST LANG, V33, P433, DOI 10.1177/0142723713493345
   Miller CA, 2006, AM J SPEECH-LANG PAT, V15, P142, DOI 10.1044/1058-0360(2006/014)
   Perkins Michael R., 2007, PRAGMATIC IMPAIRMENT
   Ryder N, 2008, INT J LANG COMM DIS, V43, P427, DOI 10.1080/13682820701633207
   Shields J, 1996, DEV MED CHILD NEUROL, V38, P487
   Spackman MP, 2006, INT J LANG COMM DIS, V41, P173, DOI 10.1080/13682820500224091
   Taylor LJ, 2012, J AUTISM DEV DISORD, V42, P2067, DOI 10.1007/s10803-012-1456-5
   Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
   World Health Organization, 1993, INT CLASS MENT BEH D
NR 31
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-2822
EI 1460-6984
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD JUL-AUG
PY 2014
VL 49
IS 4
BP 498
EP 507
DI 10.1111/1460-6984.12091
PG 10
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AN4ZW
UT WOS:000340599700008
PM 24888967
ER

PT J
AU Yu, TW
   Berry-Kravis, E
AF Yu, Timothy W.
   Berry-Kravis, Elizabeth
TI Autism and Fragile X Syndrome
SO SEMINARS IN NEUROLOGY
LA English
DT Article
DE fragile X syndrome; autism spectrum disorder; fragile X mental
   retardation protein; fragile X mental retardation 1 geneintellectual
   disability
ID DE-NOVO MUTATIONS; COPY-NUMBER VARIATION; SPECTRUM DISORDERS; SYNAPTIC
   PLASTICITY; MENTAL-RETARDATION; FUNCTIONAL IMPACT; MOUSE MODEL; CGG
   REPEAT; OPEN-LABEL; FMR1 GENE
AB Autistic spectrum disorders (ASDs) are characterized by impairments in language, social skills, and repetitive behaviors, often accompanied by intellectual disability. Advances in the genetics of ASDs are providing new glimpses into the underlying neurobiological mechanisms disrupted in these conditions. These glimpses on one hand reinforce the idea that synapse development and plasticity are one of the major pathways disrupted in autism, but beyond that are providing fresh molecular support to the idea of mechanistic parallels between idiopathic ASD and specific syndromic neurodevelopmental disorders like fragile X syndrome (FXS). Fragile X syndrome is already recognized as the most common identifiable genetic cause of intellectual disability and ASDs, with many overlapping phenotypic features. Fragile X syndrome is associated with a variety of cognitive, behavioral, physical, and medical problems, which are managed through supportive treatment. Recent major advances in the understanding of the underlying neurobiology in FXS have led to the discovery of agents that rescue phenotypes in the FXS mouse model, and early clinical trials of targeted treatments in humans with FXS. Thus translational strategies in FXS may be poised to serve as models for ASD and other cognitive disorders.
C1 [Yu, Timothy W.] Harvard Univ, Sch Med, Div Genet & Genom, Boston Childrens Hosp, Boston, MA 02115 USA.
   [Yu, Timothy W.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
   [Berry-Kravis, Elizabeth] Rush Univ, Med Ctr, Dept Pediat, Chicago, IL 60612 USA.
   [Berry-Kravis, Elizabeth] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
   [Berry-Kravis, Elizabeth] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA.
RP Yu, TW (reprint author), Harvard Univ, Sch Med, Div Genet & Genom, Boston Childrens Hosp, 300 Longwood Ave, Boston, MA 02115 USA.
EM timothy.yu@childrens.harvard.edu; Elizabeth_m_berry-kravis@rush.edu
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Bailey DB, 2012, J DEV BEHAV PEDIATR, V33, P62, DOI 10.1097/DBP.0b013e318236c0e1
   Baio J., 2014, MMWR SURVEILL SUM S2, V63, P1
   Basel-Vanagaite L, 2012, AM J HUM GENET, V91, P998, DOI 10.1016/j.ajhg.2012.10.011
   Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Berry-Kravis E, 2009, J MED GENET, V46, P266, DOI 10.1136/jmg.2008.063701
   Berry-Kravis E, 2013, J DEV BEHAV PEDIATR, V34, P508, DOI 10.1097/DBP.0b013e31829d1f20
   Berry-Kravis E, 2014, PEDIATR NEUROL, V50, P297, DOI 10.1016/j.pediatrneurol.2013.12.001
   Berry-Kravis E, 2011, J NEURODEV DISORD, V3, P193, DOI 10.1007/s11689-011-9074-7
   Berry-Kravis E, 2012, INT J PEDIAT, V2012, DOI DOI 10.1155/2012/843016
   Berry-Kravis E, 2007, MOVEMENT DISORD, V22, P2018, DOI 10.1002/mds.21493
   Berry-Kravis E., 2002, CURR PAEDIAT, V12, P316, DOI 10.1054/cupe.2002.0305
   Berry-Kravis E, 2008, J DEV BEHAV PEDIATR, V29, P293, DOI 10.1097/DBP.0b013e31817dc447
   Berry-Kravis EM, 2012, SCI TRANSL MED, V4, DOI DOI 10.1126/SCITRANSLMED.3004214
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
   Buxbaum JD, 2012, NEURON, V76, P1052, DOI 10.1016/j.neuron.2012.12.008
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111
   Coffee B, 2009, AM J HUM GENET, V85, P503, DOI 10.1016/j.ajhg.2009.09.007
   Cohen D, 2005, J AUTISM DEV DISORD, V35, P103, DOI 10.1007/s10803-004-1038-2
   Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
   Deng PY, 2013, NEURON, V77, P696, DOI 10.1016/j.neuron.2012.12.018
   Doshi-Velez F, 2014, PEDIATRICS, V133, pE54, DOI 10.1542/peds.2013-0819
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Erickson CA, 2013, PSYCHOPHARMACOLOGY, V228, P75, DOI 10.1007/s00213-013-3022-z
   FOLSTEIN S, 1977, NATURE, V265, P726, DOI 10.1038/265726a0
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
   Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Goizet C, 2000, AM J MED GENET, V96, P839, DOI 10.1002/1096-8628(20001204)96:6<839::AID-AJMG29>3.0.CO;2-R
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Grossman AW, 2006, J NEUROSCI, V26, P7151, DOI 10.1523/JNEUROSCI.1790-06.2006
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Helsmoortel C, 2014, NAT GENET, V46, P380, DOI 10.1038/ng.2899
   Henderson C, 2012, SCI TRANSL MED, V4, DOI DOI 10.1126/SCITRANSLMED.3004218
   Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
   Iliff AJ, 2013, HUM MOL GENET, V22, P1180, DOI 10.1093/hmg/dds525
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jacquemont S, 2011, SCI TRANSL MED, V3
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Jeste SS, 2011, CURR OPIN NEUROL, V24, P132, DOI 10.1097/WCO.0b013e3283446450
   Kelleher RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035003
   Kidd SL, 2014, J PEDIAT IN PRESS
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Konyukh M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017289
   Ladd PD, 2007, HUM MOL GENET, V16, P3174, DOI 10.1093/hmg/ddm293
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Lavelle TA, 2014, PEDIATRICS, V133, pE520, DOI 10.1542/peds.2013-0763
   Leigh MJS, 2013, J DEV BEHAV PEDIATR, V34, P147, DOI 10.1097/DBP.0b013e318287cd17
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   Loesch DZ, 2004, MENT RETARD DEV D R, V10, P31, DOI 10.1002/mrdd.20006
   Luo R, 2012, AM J HUM GENET, V91, P38, DOI 10.1016/j.ajhg.2012.05.011
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McBride SMJ, 2005, NEURON, V45, P753, DOI 10.1016/j.neuron.2005.01.038
   Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Novarino G, 2012, SCIENCE, V338, P394, DOI 10.1126/science.1224631
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
   Pinto D, 2014, AM J HUM GENET, V94, P677, DOI 10.1016/j.ajhg.2014.03.018
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Prasad C, 2000, CLIN GENET, V57, P103, DOI 10.1034/j.1399-0004.2000.570203.x
   Ronald A, 2006, SCIENCE, V311, P952, DOI 10.1126/science.311.5763.952a
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sandin S, 2014, JAMA-J AM MED ASSOC, V311, P1770, DOI 10.1001/jama.2014.4144
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Seltzer MM, 2012, AM J MED GENET B, V159B, P589, DOI 10.1002/ajmg.b.32065
   Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Steinberg J, 2013, AM J HUM GENET, V93, P825, DOI 10.1016/j.ajhg.2013.09.013
   Talisa VB, 2014, AM J MED GENET A, V164, P1198, DOI 10.1002/ajmg.a.36468
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Tassone F, 2012, GENOME MED, V4, DOI 10.1186/gm401
   Uddin M, 2014, NAT GENET, V46, P742, DOI 10.1038/ng.2980
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Waltes R, 2014, HUM GENET, V133, P781, DOI 10.1007/s00439-013-1416-y
   Wandstrat AE, 1998, AM J HUM GENET, V62, P925, DOI 10.1086/301777
   Wang LW, 2010, NEUROTHERAPEUTICS, V7, P264, DOI 10.1016/j.nurt.2010.05.005
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   Willemsen R, 2011, CLIN GENET, V80, P214, DOI 10.1111/j.1399-0004.2011.01723.x
   Willsey AJ, 2013, CELL, V155, P997, DOI 10.1016/j.cell.2013.10.020
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Yuskaitis CJ, 2010, BIOCHEM PHARMACOL, V79, P632, DOI 10.1016/j.bcp.2009.09.023
NR 96
TC 0
Z9 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0271-8235
EI 1098-9021
J9 SEMIN NEUROL
JI Semin. Neurol.
PD JUL
PY 2014
VL 34
IS 3
BP 258
EP 265
DI 10.1055/s-0034-1386764
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA AO4AQ
UT WOS:000341279000005
PM 25192504
ER

PT J
AU Stockler-Ipsiroglu, S
   van Karnebeek, CDM
AF Stockler-Ipsiroglu, Sylvia
   van Karnebeek, Clara D. M.
TI Cerebral Creatine Deficiencies: A Group of Treatable Intellectual
   Developmental Disorders
SO SEMINARS IN NEUROLOGY
LA English
DT Article
DE GATM; guanidinoacetate methyltransferase; SLC6A8; magnetic resonance
   spectroscopy; treatment; intellectual disability; developmental delay;
   autism
ID AMIDINOTRANSFERASE AGAT DEFICIENCY; METHYLTRANSFERASE GAMT DEFICIENCY;
   TRANSPORTER DEFICIENCY; INBORN ERROR; BRAIN; METABOLISM; ARGININE;
   DEFECT; SLC6A8; SPECTRUM
AB Currently there are 91 treatable inborn errors of metabolism that cause intellectual developmental disorders. Cerebral creatine deficiencies (CDD) comprise three of these: arginine: glycine amidinotransferase [AGAT], guanidinoacetate methyltransferase [GAMT], and X-linked creatine transporter deficiency [SLC6A8]. Intellectual developmental disorder and cerebral creatine deficiency are the hallmarks of CDD. Additional clinical features include prominent speech delay, autism, epilepsy, extrapyramidal movement disorders, and signal changes in the globus pallidus. Patients with GAMT deficiency exhibit the most severe clinical spectrum. Myopathy is a distinct feature in AGAT deficiency. Guanidinoacetate (GAA) is the immediate product in the creatine biosynthetic pathway. Low GAA concentrations in urine, plasma, and cerebrospinal fluid are characteristic diagnostic markers for AGAT deficiency, while high GAA concentrations are characteristic markers for GAMT deficiency. An elevated ratio of urinary creatine /creatinine excretion serves as a diagnostic marker in males with SLC6A8 deficiency. Treatment strategies include oral supplementation of high-dose creatine-monohydrate for all three CDD. Guanidinoacetate-reducing strategies (high-dose ornithine, arginine-restricted diet) are additionally employed in GAMT deficiency. Supplementation of substrates for intracerebral creatine synthesis (arginine, glycine) has been used additionally to treat SLC6A8 deficiency. Early recognition and treatment improves outcomes. Normal outcomes in neonatally ascertained siblings from index families with AGAT and GAMT deficiency suggest a potential benefit of newborn screening for these disorders.
C1 [Stockler-Ipsiroglu, Sylvia; van Karnebeek, Clara D. M.] Univ British Columbia, Div Biochem Dis, Dept Pediat, BC Childrens Hosp, Vancouver, BC V6H 3V4, Canada.
   [Stockler-Ipsiroglu, Sylvia; van Karnebeek, Clara D. M.] Univ British Columbia, Treatable Intellectual Disabil Endeavor British C, Vancouver, BC V6H 3V4, Canada.
   [Stockler-Ipsiroglu, Sylvia; van Karnebeek, Clara D. M.] Univ British Columbia, Child & Family Res Inst, Vancouver, BC V6H 3V4, Canada.
   [van Karnebeek, Clara D. M.] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V6H 3V4, Canada.
RP Stockler-Ipsiroglu, S (reprint author), Univ British Columbia, Dept Pediat, Child & Family Res Inst, K3-204-4480 Oak St, Vancouver, BC V6H 3V4, Canada.
EM sstockler@cw.bc.ca
FU B.C. Children's Hospital Foundation for TIDE-BC
FX This work was supported by funding from the B.C. Children's Hospital
   Foundation for TIDE-BC as the "1st Collaborative Area of Innovation."
CR Battini R, 2002, MOL GENET METAB, V77, P326, DOI 10.1016/S1096-7192(02)00175-0
   Battini R, 2006, J PEDIATR-US, V148, P828, DOI 10.1016/j.jpeds.2006.01.043
   Bianchi MC, 2007, AM J NEURORADIOL, V28, P548
   Braissant O, 2010, NEUROBIOL DIS, V37, P423, DOI 10.1016/j.nbd.2009.10.022
   Braissant O, 2001, Brain Res Mol Brain Res, V86, P193
   Cecil KM, 2001, ANN NEUROL, V49, P401, DOI 10.1002/ana.79
   Chilosi A, 2012, ORPHANET J RARE DIS, V7, DOI 10.1186/1750-1172-7-43
   DeGrauw TJ, 2002, NEUROPEDIATRICS, V33, P232, DOI 10.1055/s-2002-36743
   Dhar SU, 2009, MOL GENET METAB, V96, P38, DOI 10.1016/j.ymgme.2008.10.008
   Dunbar M, 2014, MOL GENET METAB, V112, P259, DOI 10.1016/j.ymgme.2014.05.011
   Edvardson S, 2010, MOL GENET METAB, V101, P228, DOI 10.1016/j.ymgme.2010.06.021
   Garbati P, 2014, NEUROCHEM RES, V39, P37, DOI 10.1007/s11064-013-1188-8
   Item CB, 2001, AM J HUM GENET, V69, P1127, DOI 10.1086/323765
   Kurosawa Y, 2012, J CLIN INVEST, V122, P2837, DOI 10.1172/JCI59373
   Mercimek-Mahmutoglu S, 2010, MOL GENET METAB, V101, P409, DOI 10.1016/j.ymgme.2010.08.016
   Mercimek-Mahmutoglu S, 2006, NEUROLOGY, V67, P480, DOI 10.1212/01.wnl.0000234852.43688.bf
   Mercimek-Mahmutoglu S, 2009, MOL GENET METAB, V96, P273, DOI 10.1016/j.ymgme.2008.12.020
   Morris AAM, 2007, J INHERIT METAB DIS, V30, P100, DOI 10.1007/s10545-006-0478-2
   Ndika JDT, 2012, MOL GENET METAB, V106, P48, DOI 10.1016/j.ymgme.2012.01.017
   Newmeyer A, 2007, NEUROPEDIATRICS, V38, P310, DOI 10.1055/s-2008-1065353
   Nouioua S, 2013, NEUROMUSCULAR DISORD, V23, P670, DOI 10.1016/j.nmd.2013.04.011
   Pasquali M, 2014, J INHERIT METAB DIS, V37, P231, DOI 10.1007/s10545-013-9662-7
   Rosenberg EH, 2004, AM J HUM GENET, V75, P97, DOI 10.1086/422102
   Salomons GS, 2001, AM J HUM GENET, V68, P1497, DOI 10.1086/320595
   Sinclair G, 2013, CAN NEWB CHILD SCREE
   Skelton MR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016187
   Stockler Sylvia, 2007, V46, P149
   STOCKLER S, 1994, PEDIATR RES, V36, P409
   Stockler S, 1996, AM J HUM GENET, V58, P914
   Stockler-Ipsiroglu S, 2014, MOL GENET METAB, V111, P16, DOI 10.1016/j.ymgme.2013.10.018
   Stockler-Ipsiroglu S, 2005, PHYS GUIDE TREATMENT, P255
   Trotier-Faurion A, 2014, NANOMEDICINE LOND
   Valayannopoulos V, 2012, J INHERIT METAB DIS, V35, P151, DOI 10.1007/s10545-011-9358-9
   de Kamp JMV, 2012, J INHERIT METAB DIS, V35, P141, DOI 10.1007/s10545-011-9345-1
   van de Kamp JM, 2013, J MED GENET, V50, P463, DOI 10.1136/jmedgenet-2013-101658
   van de Kamp JM, 2013, J INHERIT METAB DIS, V36, P155, DOI 10.1007/s10545-012-9537-3
   van de Kamp JM, 2011, CLIN GENET, V79, P264, DOI 10.1111/j.1399-0004.2010.01460.x
   van Karnebeek CDM, 2014, MOL GENET METAB, V111, P428, DOI 10.1016/j.ymgme.2014.01.011
   van Karnebeek CDM, 2012, MOL GENET METAB, V105, P368, DOI 10.1016/j.ymgme.2011.11.191
   Verma A, 2010, NEUROLOGY, V75, P186, DOI 10.1212/WNL.0b013e3181e7cabd
   Yu H, 2013, MOL GENET METAB, V110, P465, DOI 10.1016/j.ymgme.2013.09.018
NR 41
TC 0
Z9 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0271-8235
EI 1098-9021
J9 SEMIN NEUROL
JI Semin. Neurol.
PD JUL
PY 2014
VL 34
IS 3
BP 350
EP 356
DI 10.1055/s-0034-1386772
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA AO4AQ
UT WOS:000341279000013
PM 25192512
ER

PT J
AU Hardstaff, S
AF Hardstaff, Sarah
TI "Maybe he's on the toy train": empathising and systemising in an
   encounter with David Macaulay's Black and White
SO LITERACY
LA English
DT Article
DE children's literature; autism; fiction; narrative; picture books; reader
   response; empathy; perspective-taking
AB This study explores the responses of Abby, a young person with autism, to David Macaulay's 1990 picturebook Black and White. Although both picturebook researchers and autism practitioners focus on the importance of encouraging empathetic responses to fictional characters, I build on Louise Collins' argument that Macaulay's work offers an opportunity to develop a different kind of "moral literacy" (2002, p.31). Different ways of practising and understanding perspective-taking in relation to fiction are considered in light of Abby's responses to Black and White and to fiction more generally. This study, in considering its own weaknesses, also offers a critique of the typical approaches to picturebook research whereby taking the perspective of fictional characters is sometimes seen as indicative of reading competence.
C1 Univ Cambridge, Fac Educ, Cambridge CB2 8PQ, England.
RP Hardstaff, S (reprint author), Univ Cambridge, Fac Educ, Hills Rd, Cambridge CB2 8PQ, England.
EM sarahlayzellhardstaff@gmail.com
CR Arizpe E., 2003, CHILDREN READING PIC
   Auyeung B, 2012, J AUTISM DEV DISORD, V42, P2225, DOI 10.1007/s10803-012-1454-7
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   BROWNE A., 1992, TUNNEL
   Butler C., 2006, TEACHING CHILDRENS F, P106
   Collins L, 2002, LION UNICORN, V26, P31, DOI 10.1353/uni.2002.0002
   Colomer T., 2010, NEW DIRECTIONS PICTU
   Dodd JL, 2011, COMM DISORD Q, V33, P23, DOI 10.1177/1525740110395014
   Evans J., 2009, TALKING PAGE READING, P81
   Flyvbjerg B., 2004, QUALITATIVE RES PRAC, P420, DOI DOI 10.4135/9781848608191.D33
   HAPPE F., 2013, WISETI ANN LECT U CA
   Keen Suzanne, 2007, EMPATHY NOVEL
   Kubrick Stanley, 1980, SHINING
   Lewis David, 2001, READING CONT PICTURE
   Macaulay D., 1990, BLACK WHITE
   MACKEY M., 2003, ART NARRATIVE CHILDH, P101
   Nikolajeva M, 2012, CHILD LIT EDUC, V43, P273, DOI 10.1007/s10583-012-9163-6
   Randi J, 2010, J AUTISM DEV DISORD, V40, P890, DOI 10.1007/s10803-010-0938-6
   Scott Carole, 2006, PICTUREBOOKS WORK
   Shyamalan M. Night, 1999, 6 SENSE
NR 20
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1741-4350
EI 1741-4369
J9 LITERACY
JI Literacy
PD JUL
PY 2014
VL 48
IS 2
BP 80
EP 85
DI 10.1111/lit.12033
PG 6
WC Education & Educational Research; Linguistics; Language & Linguistics
SC Education & Educational Research; Linguistics
GA AN4ZB
UT WOS:000340597500005
ER

PT J
AU Jantzie, LL
   Getsy, PM
   Firl, DJ
   Wilson, CG
   Miller, RH
   Robinson, S
AF Jantzie, L. L.
   Getsy, P. M.
   Firl, D. J.
   Wilson, C. G.
   Miller, R. H.
   Robinson, S.
TI Erythropoietin attenuates loss of potassium chloride co-transporters
   following prenatal brain injury
SO MOLECULAR AND CELLULAR NEUROSCIENCE
LA English
DT Article
DE Calpain; Erythropoietin; Hypoxia-ischemia; KCC2; Perinatal brain injury
ID HYPOXIC-ISCHEMIC ENCEPHALOPATHY; CL-COTRANSPORTER KCC2; RECOMBINANT
   ERYTHROPOIETIN; NEUROTROPHIC FACTOR; DOWN-REGULATION; NEUROPATHIC PAIN;
   PRETERM INFANTS; CALPAIN; EXPRESSION; PHARMACOKINETICS
AB Therapeutic agents that restore the inhibitory actions of gamma-amino butyric acid (GABA) by modulating intracellular chloride concentrations will provide novel avenues to treat stroke, chronic pain, epilepsy, autism, and neurodegenerative and cognitive disorders. During development, upregulation of the potassium-chloride co-transporter KCC2, and the resultant switch from excitatory to inhibitory responses to GABA guide the formation of essential inhibitory circuits. Importantly, maturation of inhibitory mechanisms is also central to the development of excitatory circuits and proper balance between excitatory and inhibitory networks in the developing brain. Loss of KCC2 expression occurs in postmortem samples from human preterm infant brains with white matter lesions. Here we show that late gestation brain injury in a rat model of extreme prematurity impairs the developmental upregulation of potassium chloride co-transporters during a critical postnatal period of circuit maturation in CA3 hippocampus by inducing a sustained loss of oligomeric KCC2 via a calpain-dependent mechanism. Further, administration of erythropoietin (EPO) in a clinically relevant postnatal dosing regimen following the prenatal injury protects the developing brain by reducing calpain activity, restoring oligomeric KCC2 expression and attenuating KCC2 fragmentation, thus providing the first report of a safe therapy to address deficits in KCC2 expression. Together, these data indicate it is possible to reverse abnormalities in KCC2 expression during the postnatal period, and potentially reverse deficits in inhibitory circuit formation central to cognitive impairment and epileptogenesis. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Jantzie, L. L.; Firl, D. J.; Robinson, S.] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA.
   [Jantzie, L. L.; Firl, D. J.; Robinson, S.] Harvard Med Sch, Boston, MA 02115 USA.
   [Jantzie, L. L.; Firl, D. J.; Robinson, S.] Boston Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA.
   [Jantzie, L. L.; Firl, D. J.; Robinson, S.] Harvard Med Sch, Boston, MA 02115 USA.
   [Getsy, P. M.; Wilson, C. G.] Case Western Reserve Univ, Sch Med, Dept Pediat, Cleveland, OH 44106 USA.
   [Miller, R. H.] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA.
RP Robinson, S (reprint author), Boston Childrens Hosp, Dept Neurosurg, Hunnewell 2,300 Longwood Ave, Boston, MA 02115 USA.
EM Shenandoah.Robinson@childrens.harvard.edu
FU National Institute of Neurological Diseases and Stroke at the National
   Institutes of Health [RO1 NS060765]
FX This work was supported by the National Institute of Neurological
   Diseases and Stroke at the National Institutes of Health (RO1 NS060765
   to S.R.). We thank Cecil Yeung, James Messegee, Elizabeth Schick, Mark
   Eden, and Qing Li for their exceptional technical assistance. We are
   very appreciative of the Boston Children's Hospital Intellectual and
   Developmental Disabilities Research Center (BCH IDDRC) Cellular Imaging
   Core (P30 HD18655).
CR Amini M, 2013, J NEUROSCI, V33, P5773, DOI 10.1523/JNEUROSCI.4247-12.2013
   Aronica E, 2007, NEUROSCIENCE, V145, P185, DOI 10.1016/j.neuroscience.2006.11.041
   Ben-Ari Y, 2002, NAT REV NEUROSCI, V3, P728, DOI 10.1038/nrn920
   Ben-Ari Y, 2012, NEUROSCIENTIST, V18, P467, DOI 10.1177/1073858412438697
   Blaesse P., 2006, J NEUROSCI, V2641
   Boulenguez P, 2010, NAT MED, V16, P302, DOI 10.1038/nm.2107
   Chen Z.-Y., 2007, J BIOL CHEM, V28, P25857
   Coull JAM, 2005, NATURE, V438, P1017, DOI 10.1038/nature04223
   Daw MI, 2007, NAT NEUROSCI, V10, P453, DOI 10.1038/nn1866
   Digicaylioglu M, 2001, NATURE, V412, P641, DOI 10.1038/35088074
   D'Orsi B, 2012, J NEUROSCI, V32, P1847, DOI 10.1523/JNEUROSCI.2345-11.2012
   Dzhala VI, 2005, NAT MED, V11, P1205, DOI 10.1038/nm1301
   Elmahdy H, 2010, PEDIATRICS, V125, pE1135, DOI 10.1542/peds.2009-2268
   Farrant M, 2007, PROG BRAIN RES, V160, P59, DOI 10.1016/S0079-6123(06)60005-8
   Fauchere JC, 2008, PEDIATRICS, V122, P375, DOI 10.1542/peds.2007-2591
   Ferrini F, 2013, NAT NEUROSCI, V16, P183, DOI 10.1038/nn.3295
   Fuchs A, 2010, J NEUROPATH EXP NEUR, V69, P1057, DOI 10.1097/NEN.0b013e3181f4dcef
   Hirano K, 2012, J CELL MOL MED, V16, P1792, DOI 10.1111/j.1582-4934.2011.01489.x
   Huang X, 2012, NEUROSCIENCE, V219, P33, DOI 10.1016/j.neuroscience.2012.05.003
   Huberfeld G, 2007, J NEUROSCI, V27, P9866, DOI 10.1523/JNEUROSCI.2761-07.2007
   Hull C, 2007, NAT NEUROSCI, V10, P400, DOI 10.1038/nn0407-400
   Jaenisch N, 2010, STROKE, V41, pE151, DOI 10.1161/STROKEAHA.109.570424
   Jantzie L., 2014, CEREB CORTE IN PRESS
   Jantzie LL, 2013, PEDIATR RES, V74, P658, DOI 10.1038/pr.2013.155
   Juul SE, 2008, PEDIATRICS, V122, P383, DOI 10.1542/peds.2007-2711
   Kanold PO, 2006, NEURON, V51, P627, DOI 10.1016/j.neuron.2006.07.008
   Lee HHC, 2011, NAT NEUROSCI, V14, P736, DOI 10.1038/nn.2806
   Lee HHC, 2007, J BIOL CHEM, V282, P29777, DOI 10.1074/jbc.M705053200
   Li YZ, 2009, EXP NEUROL, V220, P316, DOI 10.1016/j.expneurol.2009.09.004
   Ludwig A, 2011, J NEUROSCI, V31, P644, DOI 10.1523/JNEUROSCI.2006-10.2011
   Marin-Padilla M, 2000, ADV NEUROL, V84, P153
   Martin JA, 2011, DIVISION VITAL STAT, V60, P1
   MARTIN SJ, 1995, J BIOL CHEM, V270, P6425
   Martinez-Biarge M, 2010, EARLY HUM DEV, V86, P675, DOI 10.1016/j.earlhumdev.2010.08.013
   Matoba N, 2009, PEDIATRICS, V123, P1320, DOI 10.1542/peds.2008-1222
   Mazur M, 2010, J NEUROSURG-PEDIATR, V6, P206, DOI 10.3171/2010.5.PEDS1032
   McAdams RM, 2012, J PERINATOL, V33, P226
   McPherson RJ, 2010, CURR OPIN PEDIATR, V22, P139, DOI 10.1097/MOP.0b013e328336eb57
   Messier AM, 2014, CURR OPIN PEDIATR, V26, P139, DOI 10.1097/MOP.0000000000000077
   Metin C, 2006, EUR J NEUROSCI, V23, P894, DOI 10.1111/j.1460-9568.2006.04630.x
   Miskowiak K, 2007, J NEUROSCI, V27, P2788, DOI 10.1523/JNEUROSCI.5013-06.2007
   Miskowiak K, 2008, NEUROPSYCHOPHARMACOL, V33, P611, DOI 10.1038/sj.npp.1301439
   Montero M, 2007, EXP NEUROL, V204, P106, DOI 10.1016/j.expneurol.2006.09.026
   Munoz A, 2007, EPILEPSIA, V48, P663, DOI 10.1111/j.1528-1167.2007.00986.x
   Ponce Lucido L, 2013, Pathophysiology, V20, P31, DOI 10.1016/j.pathophys.2012.02.005
   Puskarjov M, 2012, J NEUROSCI, V32, P11356, DOI 10.1523/JNEUROSCI.6265-11.2012
   Rivera C, 2002, J CELL BIOL, V159, P747, DOI 10.1083/jcb.200209011
   ROBERTSLEWIS JM, 1994, J NEUROSCI, V14, P3934
   Robinson S, 2005, NEUROBIOL DIS, V18, P568, DOI 10.1016/j.nbd.2004.10.024
   Robinson S, 2005, EPILEPSY BEHAV, V7, P345, DOI 10.1016/j.yebeh.2005.06.005
   Robinson S, 2010, J NEUROPATH EXP NEUR, V69, P565, DOI 10.1097/NEN.0b013e3181dd25bc
   Saatman KE, 2010, NEUROTHERAPEUTICS, V7, P31, DOI 10.1016/j.nurt.2009.11.002
   Shulga A, 2008, J NEUROSCI, V28, P6996, DOI 10.1523/JNEUROSCI.5268-07.2008
   Statler PA, 2007, PEDIATR RES, V61, P671, DOI 10.1203/pdr.0b013e31805341dc
   Tsai PT, 2006, J NEUROSCI, V26, P1269, DOI 10.1523/JNEUROSCI.4480-05.2006
   Viviani B, 2005, J NEUROCHEM, V93, P412, DOI 10.1111/j.1471-4159.2005.03033.x
   Volpe JJ, 2009, LANCET NEUROL, V8, P110, DOI 10.1016/S1474-4422(08)70294-1
   Volpe JJ, 2011, INT J DEV NEUROSCI, V29, P423, DOI 10.1016/j.ijdevneu.2011.02.012
   Wardle RA, 2003, J NEUROSCI, V23, P8722
   Weishaupt N, 2012, EXP NEUROL, V238, P254, DOI 10.1016/j.expneurol.2012.09.001
   Wu YW, 2012, PEDIATRICS, V130, P683, DOI 10.1542/peds.2012-0498
   Xenocostas A, 2005, EUR J CLIN PHARMACOL, V61, P189, DOI 10.1007/s00228-005-0896-7
   Yeo M, 2009, J NEUROSCI, V29, P14652, DOI 10.1523/JNEUROSCI.2934-09.2009
   Zhou HY, 2012, J BIOL CHEM, V287, P33853, DOI 10.1074/jbc.M112.395830
NR 64
TC 2
Z9 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1044-7431
EI 1095-9327
J9 MOL CELL NEUROSCI
JI Mol. Cell. Neurosci.
PD JUL
PY 2014
VL 61
BP 152
EP 162
DI 10.1016/j.mcn.2014.06.009
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA AN6FN
UT WOS:000340690400015
PM 24983520
ER

PT J
AU Warlaumont, AS
   Richards, JA
   Gilkerson, J
   Oller, DK
AF Warlaumont, Anne S.
   Richards, Jeffrey A.
   Gilkerson, Jill
   Oller, D. Kimbrough
TI A Social Feedback Loop for Speech Development and Its Reduction in
   Autism
SO PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE social interaction; speech development; autism; socioeconomic status;
   rewards
ID AUTOMATED VOCAL ANALYSIS; JOINT ATTENTION; SPECTRUM DISORDER; BRAIN
   OVERGROWTH; CHILDREN; LANGUAGE; COMMUNICATION; INTERVENTION; ABILITIES;
   INFANTS
AB We analyzed the microstructure of child-adult interaction during naturalistic, daylong, automatically labeled audio recordings (13,836 hr total) of children (8- to 48-month-olds) with and without autism. We found that an adult was more likely to respond when the child's vocalization was speech related rather than not speech related. In turn, a child's vocalization was more likely to be speech related if the child's previous speech-related vocalization had received an immediate adult response rather than no response. Taken together, these results are consistent with the idea that there is a social feedback loop between child and caregiver that promotes speech development. Although this feedback loop applies in both typical development and autism, children with autism produced proportionally fewer speech-related vocalizations, and the responses they received were less contingent on whether their vocalizations were speech related. We argue that such differences will diminish the strength of the social feedback loop and have cascading effects on speech development over time. Differences related to socioeconomic status are also reported.
C1 [Warlaumont, Anne S.] Univ Calif Merced, Merced, CA 95343 USA.
   [Richards, Jeffrey A.; Gilkerson, Jill] LENA Res Fdn, Boulder, CO USA.
   [Gilkerson, Jill] Univ Colorado, Dept Speech Language & Hearing Sci, Boulder, CO 80309 USA.
   [Oller, D. Kimbrough] Univ Memphis, Sch Commun Sci & Disorders, Memphis, TN 38152 USA.
   [Oller, D. Kimbrough] Konrad Lorenz Inst Evolut & Cognit Res, Klosterneuburg, Austria.
RP Warlaumont, AS (reprint author), Univ Calif Merced, Sch Social Sci Humanities & Arts, 5200 North Lake Rd, Merced, CA 95343 USA.
EM awarlaumont2@ucmerced.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Amorosa H., 1992, NONVERBAL VOCAL COMM, P192
   Anderson DK, 2007, J CONSULT CLIN PSYCH, V75, P594, DOI 10.1037/0022-006X.75.4.594
   BLOOM K, 1988, J CHILD LANG, V15, P469
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   GIROLAMETTO LE, 1988, J SPEECH HEAR DISORD, V53, P156
   Goldstein MH, 2008, PSYCHOL SCI, V19, P515, DOI 10.1111/j.1467-9280.2008.02117.x
   Goldstein MH, 2003, P NATL ACAD SCI USA, V100, P8030, DOI 10.1073/pnas.1332441100
   Greenwood CR, 2011, COMM DISORD Q, V32, P83, DOI 10.1177/1525740110367826
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Hoff E, 2003, CHILD DEV, V74, P1368, DOI 10.1111/1467-8624.00612
   Jaffe J, 2001, MONOGR SOC RES CHILD, V66, P1, DOI 10.1111/1540-5834.00137
   Karmiloff-Smith A, 1998, TRENDS COGN SCI, V2, P389, DOI 10.1016/S1364-6613(98)01230-3
   Keller H, 1999, CHILD DEV, V70, P474, DOI 10.1111/1467-8624.00034
   KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995
   LANDA R, 1992, PSYCHOL MED, V22, P245
   Leezenbaum NB, 2014, AUTISM, V18, P694, DOI 10.1177/1362361313491327
   Mundy P, 1997, J AUTISM DEV DISORD, V27, P653, DOI 10.1023/A:1025802832021
   Mundy P, 2001, INT REV RES MENT RET, V23, P139
   National Research Council, 2001, ED CHILDR AUT
   Oller D. K., 2000, EMERGENCE SPEECH CAP
   Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107
   Patten E., 2014, J AUTISM DEV DISORDE
   Paul R, 2011, J CHILD PSYCHOL PSYC, V52, P588, DOI 10.1111/j.1469-7610.2010.02332.x
   Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
   Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
   Ramscar M, 2013, PSYCHOL SCI, V24, P1017, DOI 10.1177/0956797612460691
   Ramscar M, 2010, COGNITIVE SCI, V34, P909, DOI 10.1111/j.1551-6709.2009.01092.x
   Risley T. R., 1995, MEANINGFUL DIFFERENC
   Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155
   Sheinkopf SJ, 2012, AUTISM RES, V5, P331, DOI 10.1002/aur.1244
   Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
   Tamis-LeMonda CS, 2001, CHILD DEV, V72, P748, DOI 10.1111/1467-8624.00313
   Thompson-Schill SL, 2009, CURR DIR PSYCHOL SCI, V18, P259
   Warren SF, 2010, J AUTISM DEV DISORD, V40, P555, DOI 10.1007/s10803-009-0902-5
   Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
   Yoder PJ, 1999, J EARLY INTERVENTION, V22, P126
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 41
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0956-7976
EI 1467-9280
J9 PSYCHOL SCI
JI Psychol. Sci.
PD JUL
PY 2014
VL 25
IS 7
BP 1314
EP 1324
DI 10.1177/0956797614531023
PG 11
WC Psychology, Multidisciplinary
SC Psychology
GA AM8NA
UT WOS:000340131300003
PM 24840717
ER

PT J
AU Wagner, DV
   Borduin, CM
   Kanne, SM
   Mazurek, MO
   Farmer, JE
   Brown, RMA
AF Wagner, David V.
   Borduin, Charles M.
   Kanne, Stephen M.
   Mazurek, Micah O.
   Farmer, Janet E.
   Brown, Rachel M. A.
TI MULTISYSTEMIC THERAPY FOR DISRUPTIVE BEHAVIOR PROBLEMS IN YOUTHS WITH
   AUTISM SPECTRUM DISORDERS: A PROGRESS REPORT
SO JOURNAL OF MARITAL AND FAMILY THERAPY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; INTELLECTUAL DISABILITY; FAMILY
   THERAPISTS; COPING STRATEGIES; PARENTING STRESS; PRESCHOOL-CHILDREN;
   SOCIAL SUPPORT; YOUNG-ADULTS; ADOLESCENTS; ADJUSTMENT
AB Youths with autism spectrum disorders (ASD) often engage in serious disruptive behaviors that interfere with their ability to successfully manage day-to-day responsibilities and contribute to relationship problems with caregivers, peers, and teachers. Effective treatments are needed to address the factors linked with disruptive behavior problems in this population of youths. Multisystemic therapy (MST) is a comprehensive family-and community-based treatment approach that has been effective with other difficult-to-treat populations of youths and holds promise for youths with ASD. In this article, we review the broad range of factors associated with disruptive behaviors among youths with ASD and discuss how MST interventions can be adapted to address those factors. We also present a framework for our adaptation of the MST model for youths with ASD. This framework includes a recently completed pilot study as well as an ongoing efficacy trial that together have served to identify key interventions for our adaptation of the MST model.
C1 [Wagner, David V.; Borduin, Charles M.; Kanne, Stephen M.; Mazurek, Micah O.; Farmer, Janet E.; Brown, Rachel M. A.] Univ Missouri, Columbia, MO 65211 USA.
RP Borduin, CM (reprint author), Univ Missouri, 108A McAlester Hall,S 6th St, Columbia, MO 65211 USA.
EM borduinc@missouri.edu
CR Abidin RR, 1995, PARENTING STRESS IND
   Achenbach TM, 1991, MANUAL CHILD BEHAV C
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Baker JK, 2011, J FAM PSYCHOL, V25, P601, DOI 10.1037/a0024409
   Baker JK, 2011, J ABNORM PSYCHOL, V120, P465, DOI 10.1037/a0021900
   Bauminger N, 2003, AUTISM, V7, P81, DOI 10.1177/1362361303007001007
   Bayat M, 2007, J INTELL DISABIL RES, V51, P702, DOI 10.1111/j.1365-2788.2007.00960.x
   Benson BA, 1999, HDB DISRUPTIVE BEHAV, P559
   Benson PR, 2008, RES AUTISM SPECT DIS, V2, P583, DOI 10.1016/j.rasd.2007.12.002
   Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
   Bolte S, 1999, PSYCHOPATHOLOGY, V32, P93, DOI 10.1159/000029072
   Borduin C. M., 2010, J FAMILY PSYCHOL, V24, P655
   Bronfenbrenner U., 1979, ECOLOGY HUMAN DEV EX
   Brookman-Frazee L, 2009, J MENT HEALTH RES IN, V2, P201, DOI 10.1080/19315860902741542
   Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   de Bildt A, 2005, J CHILD PSYCHOL PSYC, V46, P275, DOI 10.1111/j.1469-7610.2004.00346.x
   Derogatis L. R., 1993, BSI BRIEF SYMPTOM IN
   Dominick KC, 2007, RES DEV DISABIL, V28, P145, DOI 10.1016/j.ridd.2006.02.003
   Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
   Farmer CA, 2011, RES AUTISM SPECT DIS, V5, P317, DOI 10.1016/j.rasd.2010.04.014
   Farmer J. E., 2012, CASE SERIES UNPUB
   Fletcher Paula C, 2012, Issues Compr Pediatr Nurs, V35, P45, DOI 10.3109/01460862.2012.645407
   Freedman BH, 2012, J AUTISM DEV DISORD, V42, P539, DOI 10.1007/s10803-011-1269-y
   GALLAGHER JJ, 1983, EXCEPT CHILDREN, V50, P10
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Gau SSF, 2012, RES AUTISM SPECT DIS, V6, P263, DOI 10.1016/j.rasd.2011.05.007
   Gurney JG, 2006, ARCH PEDIAT ADOL MED, V160, P825, DOI 10.1001/archpedi.160.8.825
   Hartley SL, 2010, J FAM PSYCHOL, V24, P449, DOI 10.1037/a0019847
   Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
   Hastings RP, 2002, MENT RETARD, V40, P148, DOI 10.1352/0047-6765(2002)040<0148:CSATIO>2.0.CO;2
   Hastings RP, 2003, J AUTISM DEV DISORD, V33, P141, DOI 10.1023/A:1022983209004
   Henggeler S., 1990, FAMILY THERAPY MULTI
   Henggeler S. W., 2009, MULTISYSTEMIC THERAP
   Henggeler SW, 2012, J MARITAL FAM THER, V38, P30, DOI 10.1111/j.1752-0606.2011.00244.x
   Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
   Hoffman L., 1981, FDN FAMILY THERAPY
   Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
   Humphrey N, 2011, AUTISM, V15, P397, DOI 10.1177/1362361310387804
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P1007, DOI 10.1007/s10803-010-1126-4
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
   Koning C, 2001, AUTISM, V5, P23, DOI 10.1177/1362361301005001003
   KONSTANTAREAS MM, 1992, J MARRIAGE FAM, V54, P153, DOI 10.2307/353283
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
   Little Liza, 2002, Issues Compr Pediatr Nurs, V25, P43, DOI 10.1080/014608602753504847
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Macken J., 2009, J MENTAL HLTH RES IN, V2, P29
   McIntyre LL, 2002, J INTELL DISABIL RES, V46, P239, DOI 10.1046/j.1365-2788.2002.00371.x
   Miller Marna G., 2009, VICTIMS OFFENDERS, V4, P170, DOI DOI 10.1080/15564880802612615
   Montes G, 2007, PEDIATRICS, V119, pE1040, DOI 10.1542/peds.2006-2819
   National Research Council, 2001, ED CHILDR AUT
   Neely J, 2012, J MARITAL FAM THER, V38, P211, DOI 10.1111/j.1752-0606.2011.00265.x
   Nelson K. E., 1992, ALTERNATIVE MODELS F
   Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
   Petalas MA, 2009, AUTISM, V13, P471, DOI 10.1177/1362361309335721
   Portner J., 1982, FAMILY INVENTORIES, P5
   PROCIDANO ME, 1983, AM J COMMUN PSYCHOL, V11, P1, DOI 10.1007/BF00898416
   Ramisch J, 2012, J MARITAL FAM THER, V38, P305, DOI 10.1111/j.1752-0606.2010.00210.x
   Ross P, 2006, J INTELLECT DEV DIS, V31, P77, DOI 10.1080/13668250600710864
   Rutter M., 2005, HDB AUTISM PERVASIVE, V1, P425
   Sawyer AM, 2011, J CONSULT CLIN PSYCH, V79, P643, DOI 10.1037/a0024862
   Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
   Siegel B., 1997, HDB AUTISM PERVASIVE, P5
   Sivberg B, 2002, AUTISM, V6, P397, DOI 10.1177/1362361302006004006
   Solomon AH, 2012, FAM PROCESS, V51, P250, DOI 10.1111/j.1545-5300.2012.01399.x
   Stuart M, 2009, RES AUTISM SPECT DIS, V3, P86, DOI 10.1016/j.rasd.2008.04.006
   Wagner D. V., 2012, LONG TERM PREV UNPUB
   Warren Z., 2011, COMP EFFECTIVENESS R, V26
   Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
   Bauminger N, 2001, RESEARCH BASIS FOR AUTISM INTERVENTION, P151
NR 73
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0194-472X
EI 1752-0606
J9 J MARITAL FAM THER
JI J. Marital Fam. Ther.
PD JUL
PY 2014
VL 40
IS 3
BP 319
EP 331
DI 10.1111/jmft.12012
PG 13
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA AM6HF
UT WOS:000339964100005
PM 24749815
ER

PT J
AU Bourne, Y
   Marchot, P
AF Bourne, Yves
   Marchot, Pascale
TI The Neuroligins and Their Ligands: from Structure to Function at the
   Synapse
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article; Proceedings Paper
CT 14th International Symposium on Cholinergic Mechanisms (ISCM)
CY MAY, 2013
CL Hangzhou, PEOPLES R CHINA
DE Acetylcholinesterase; Adhesion; alpha/beta-hydrolase; Autism; Complex;
   Ectodomain; Enzyme; Model; Neurexin; Neuroligin; Partnership; Structure;
   Synapse
ID CELL-ADHESION MOLECULES; CRYSTAL-STRUCTURE; BETA-NEUREXINS;
   EXTRACELLULAR DOMAIN; INHIBITORY SYNAPSES; ALPHA-NEUREXINS; NMDA
   RECEPTORS; PROTEIN; BINDING; ACETYLCHOLINESTERASE
AB The neuroligins are cell adhesion proteins whose extracellular domain belongs to the alpha/beta-hydrolase fold family of proteins, mainly containing enzymes and exemplified by acetylcholinesterase. The ectodomain of postsynaptic neuroligins interacts through a calcium ion with the ectodomain of presynaptic neurexins to form flexible trans-synaptic associations characterized by selectivity for neuroligin or neurexin subtypes. This heterophilic interaction, essential for synaptic differentiation, maturation, and maintenance, is regulated by gene selection, alternative mRNA splicing, and posttranslational modifications. Mutations leading to deficiencies in the expression, folding, maturation, and binding properties of either partner are associated with autism spectrum disorders. The currently available structural and functional data illustrate how these two families of cell adhesion molecules bridge the synaptic cleft to participate in synapse plasticity and support its dynamic nature. Neuroligin partners distinct from the neurexins, and which may undergo either trans or cis interaction, have also been described, and tridimensional structures of some of them are available. Our study emphasizes the partnership versatility of the neuroligin ectodomain associated with molecular flexibility and alternative binding sites, proposes homology models of the structurally non-characterized neuroligin partners, and exemplifies the large structural variability at the surface of the alpha/beta-hydrolase fold subunit. This study also provides new insights into possible surface binding sites associated with non-catalytic properties of the acetylcholinesterase subunit.
C1 [Bourne, Yves; Marchot, Pascale] Aix Marseille Univ, CNRS, F-13288 Marseille 09, France.
RP Bourne, Y (reprint author), Aix Marseille Univ, CNRS, Campus Luminy Case 932, F-13288 Marseille 09, France.
EM yves.bourne@afmb.univ-mrs.fr; pascale.marchot@univ-amu.fr
CR Adams JC, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a009712
   Alonso A, 2004, CELL, V117, P699, DOI 10.1016/j.cell.2004.05.018
   Arac D, 2007, NEURON, V56, P992, DOI 10.1016/j.neuron.2007.12.002
   Aricescu AR, 2007, SCIENCE, V317, P1217, DOI 10.1126/science.1144646
   Barrow SL, 2009, NEURAL DEV, V4, DOI 10.1186/1749-8104-4-17
   Berson A, 2008, BRAIN, V131, P109, DOI 10.1093/brain/awm276
   Boucard AA, 2005, NEURON, V48, P229, DOI 10.1016/j.neuron.2005.08.026
   Bourne Y, 2003, EMBO J, V22, P1, DOI 10.1093/emboj/cdg005
   Budreck EC, 2007, EUR J NEUROSCI, V26, P1738, DOI 10.1111/j.1460-9568.2007.05842.x
   Budreck EC, 2013, P NATL ACAD SCI USA, V110, P725, DOI 10.1073/pnas.1214718110
   Carlson CB, 2005, NAT STRUCT MOL BIOL, V12, P910, DOI 10.1038/nsmb997
   Chen F, 2011, STRUCTURE, V19, P779, DOI 10.1016/j.str.2011.03.012
   Chen X, 2008, NAT STRUCT MOL BIOL, V15, P50, DOI 10.1038/nsmb1350
   Comoletti D, 2006, BIOCHEMISTRY-US, V45, P12816, DOI 10.1021/bi0614131
   Comoletti D, 2007, STRUCTURE, V15, P693, DOI 10.1016/j.str.2007.04.010
   Comoletti D, 2010, STRUCTURE, V18, P1044, DOI 10.1016/j.str.2010.06.005
   de Wit J, 2009, NEURON, V64, P799, DOI 10.1016/j.neuron.2009.12.019
   Dinamarca MC, 2011, BIOCHEMISTRY-US, V50, P8127, DOI 10.1021/bi201246t
   Emsley P, 2004, ACTA CRYSTALLOGR D, V60, P2126, DOI 10.1107/S0907444904019158
   Fabrichny IP, 2007, NEURON, V56, P979, DOI 10.1016/j.neuron.2007.11.013
   Harrison D, 2007, J BIOL CHEM, V282, P11573, DOI 10.1074/jbc.M610657200
   Hoon M, 2011, P NATL ACAD SCI USA, V108, P3053, DOI 10.1073/pnas.1006946108
   ICHTCHENKO K, 1995, CELL, V81, P435, DOI 10.1016/0092-8674(95)90396-8
   Ichtchenko K, 1996, J BIOL CHEM, V271, P2676
   Iida Junko, 2004, Molecular and Cellular Neuroscience, V27, P497, DOI 10.1016/j.mcn.2004.08.006
   Inestrosa NC, 2008, FEBS J, V275, P625, DOI 10.1111/j.1742-4658.2007.06238.x
   Jamain S, 2003, NAT GENET, V34, P29
   Johnson G, 2004, BIOCHEM BIOPH RES CO, V319, P448, DOI 10.1016/j.bbrc.2004.05.018
   Johnson G, 2008, BIOCHEM J, V411, P507, DOI 10.1042/BJ20071404
   Karakas E, 2011, NATURE, V475, P249, DOI 10.1038/nature10180
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Ko J, 2009, NEURON, V64, P791, DOI 10.1016/j.neuron.2009.12.012
   Koehnke J, 2010, NEURON, V67, P61, DOI 10.1016/j.neuron.2010.06.001
   Koehnke J, 2008, P NATL ACAD SCI USA, V105, P1873, DOI 10.1073/pnas.0711701105
   LAWLER J, 1985, J BIOL CHEM, V260, P3762
   Lee K, 2013, P NATL ACAD SCI USA, V110, P336, DOI 10.1073/pnas.1219987110
   Lenfant N, 2014, J MOL NEURO IN PRESS
   Lenfant N, 2013, NUCLEIC ACIDS RES, V41, pD423, DOI 10.1093/nar/gks1154
   Leone P, 2010, EMBO J, V29, P2461, DOI 10.1038/emboj.2010.123
   Lim SH, 2009, EMBO J, V28, P3564, DOI 10.1038/emboj.2009.289
   Linhoff MW, 2009, NEURON, V61, P734, DOI 10.1016/j.neuron.2009.01.017
   Litwack ED, 2004, MOL CELL NEUROSCI, V25, P263, DOI 10.1016/j.mcn.2003.10.016
   Matsuda K, 2011, EUR J NEUROSCI, V33, P1447, DOI 10.1111/j.1460-9568.2011.07638.x
   Miller MT, 2011, STRUCTURE, V19, P767, DOI 10.1016/j.str.2011.03.011
   Misenheimer TM, 2000, J BIOL CHEM, V275, P40938, DOI 10.1074/jbc.M007022200
   Missler M, 1998, J BIOL CHEM, V273, P34716, DOI 10.1074/jbc.273.52.34716
   Nguyen T, 1997, J BIOL CHEM, V272, P26032, DOI 10.1074/jbc.272.41.26032
   Paoletti P, 2011, EUR J NEUROSCI, V33, P1351, DOI 10.1111/j.1460-9568.2011.07628.x
   Paraoanu LE, 2004, FEBS LETT, V576, P161, DOI 10.1016/j.tebslet.2004.08.078
   Pettem KL, 2013, J CELL BIOL, V200, P321, DOI 10.1083/jcb.201206028
   Poulopoulos A, 2009, NEURON, V63, P628, DOI 10.1016/j.neuron.2009.08.023
   Reissner C, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-9-213
   Rudenko G, 2001, TRENDS BIOCHEM SCI, V26, P363, DOI 10.1016/S0968-0004(01)01832-1
   SALI A, 1995, PROTEINS, V23, P318, DOI 10.1002/prot.340230306
   Savtchenko LP, 2007, P NATL ACAD SCI USA, V104, P1823, DOI 10.1073/pnas.0606636104
   Schrodinger LLC, 2010, PYMOL MOL GRAPH SYST
   Shen KC, 2008, STRUCTURE, V16, P422, DOI 10.1016/j.str.2008.01.005
   Shipman SL, 2012, NEURON, V76, P309, DOI 10.1016/j.neuron.2012.07.024
   Siddiqui TJ, 2010, J NEUROSCI, V30, P7495, DOI 10.1523/JNEUROSCI.0470-10.2010
   Silman I, 2005, CURR OPIN PHARMACOL, V5, P293, DOI 10.1016/j.coph.2005.01.014
   Sobolevsky AI, 2009, NATURE, V462, P745, DOI 10.1038/nature08624
   Soding J, 2005, NUCLEIC ACIDS RES, V33, pW244, DOI 10.1093/nar/gki408
   Song JY, 1999, P NATL ACAD SCI USA, V96, P1100, DOI 10.1073/pnas.96.3.1100
   Sperling LE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036683
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Sugita S, 2001, J CELL BIOL, V154, P435, DOI 10.1083/jcb.200105003
   SUSSMAN JL, 1991, SCIENCE, V253, P872, DOI 10.1126/science.1678899
   Tan K, 2006, STRUCTURE, V14, P33, DOI 10.1016/j.str.2005.09.017
   Tanaka H, 2012, CELL REPORTS, V2, P101, DOI 10.1016/j.celrep.2012.06.009
   TAYLOR P, 1994, ANNU REV PHARMACOL, V34, P281
   Uemura T, 2010, CELL, V141, P1068, DOI 10.1016/j.cell.2010.04.035
   USHKARYOV YA, 1992, SCIENCE, V257, P50, DOI 10.1126/science.1621094
   Varoqueaux F, 2004, EUR J CELL BIOL, V83, P449, DOI 10.1078/0171-9335-00410
   Von Castelmur E, 2008, P NATL ACAD SCI USA, V105, P1186, DOI 10.1073/pnas.0707163105
   Xu JY, 2010, NAT NEUROSCI, V13, P22, DOI 10.1038/nn.2459
NR 75
TC 1
Z9 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD JUL
PY 2014
VL 53
IS 3
BP 387
EP 396
DI 10.1007/s12031-014-0234-6
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AM6ES
UT WOS:000339956700015
PM 24497299
ER

PT J
AU Nakai, T
   Nagai, T
   Wang, R
   Yamada, S
   Kuroda, K
   Kaibuchi, K
   Yamada, K
AF Nakai, Tsuyoshi
   Nagai, Taku
   Wang, Rui
   Yamada, Shinnosuke
   Kuroda, Keisuke
   Kaibuchi, Kozo
   Yamada, Kiyofumi
TI Alterations of GABAergic and dopaminergic systems in mutant mice with
   disruption of exons 2 and 3 of the Disc1 gene
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE Disc1; Dopamine release; Methamphetamine; Parvalbumin-positive
   interneuron; Schizophrenia
ID CONDITIONED PLACE PREFERENCE; VENTRAL TEGMENTAL AREA; IN-VIVO
   MICRODIALYSIS; PREFRONTAL CORTEX; WORKING-MEMORY; ANIMAL-MODELS;
   HIPPOCAMPAL INTERNEURONS; BEHAVIORAL DEFICITS; NEUROTROPHIC FACTOR;
   INHIBITORY NEURONS
AB Disrupted-in-schizophrenia-1 (DISC1) has been widely associated with several psychiatric disorders, including schizophrenia, mood disorders and autism. We previously reported that a deficiency of DISCI may induce low anxiety and/or high impulsivity in mice with disruption of exons 2 and 3 of the Disc) gene (Disc1(Delta 2-3/Delta 2-3)). It remains unclear, however, if deficiency of DISCI leads to specific alterations in distinct neuronal systems. In the present study, to understand the role of DISCI in gamma-aminobutyric acid (GABA) interneurons and mesocorticolimbic dopaminergic (DAergic) neurons, we investigated the number of parvalbumin (PV)-positive interneurons, methamphetamine (METH)-induced DA release and the expression levels of GABA(A), DA transporter (DAT) and DA receptors in wild-type (Disc1(+/+)) and Disc1(Delta 2-3/Delta 2-3) mice. Female Disc1(Delta 2-3/Delta 2-3) mice showed a significant reduction of PV-positive interneurons in the hippocampus, while no apparent changes were observed in mRNA expression levels of GABA(A) receptor subunits. METH-induced DA release was significantly potentiated in the nucleus accumbens (NAc) of female Disc1(Delta 2-3/Delta 2-3) mice, although there were no significant differences in the expression levels of DAT. Furthermore, the expression levels of DA receptor mRNA were upregulated in the NAc of female Disc1(Delta 2-3/Delta 2-3) mice. Male Disc1(Delta 2-3/Delta 2-3) mice showed no apparent differences in all experiments. DISCI may play a critical role in gender-specific developmental alteration in GABAergic inhibitory interneurons and DAergic neurons. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Nakai, Tsuyoshi; Nagai, Taku; Wang, Rui; Yamada, Shinnosuke; Yamada, Kiyofumi] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Showa Ku, Nagoya, Aichi 4668560, Japan.
   [Nakai, Tsuyoshi; Nagai, Taku; Wang, Rui; Yamada, Shinnosuke; Yamada, Kiyofumi] Nagoya Univ, Grad Sch Med, Hosp Pharm, Showa Ku, Nagoya, Aichi 4668560, Japan.
   [Kuroda, Keisuke; Kaibuchi, Kozo] Nagoya Univ, Grad Sch Med, Dept Cell Pharmacol, Showa Ku, Nagoya, Aichi 4668560, Japan.
RP Yamada, K (reprint author), Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4668560, Japan.
EM kyamada@med.nagoya-u.ac.jp
RI Kuroda, Keisuke/K-5255-2013
OI Kuroda, Keisuke/0000-0002-6715-5125
FU JSPS KAKENHI from JST [243493]; JSPS; SRPBS from MEXT, CREST; MEXT
   [24111518, 25116515, 25460093, 26670121, 26293053]; MHLW
   [H25-Iyaku-Ippan-020]; Intramural Research Grant for Neurological and
   Psychiatric Disorders of NCNP [24-12]; SRF Grant for Biomedical Research
FX We thank the Division for Research of Laboratory Animals, Center for
   Research of Laboratory Animals and Medical Research Engineering
   (Technical Staff, Yasutaka Ohya and Kumiko Yano) for animal care and
   use. This work was supported by the following funding sources: JSPS
   KAKENHI (243493) from JST, Exploratory Research from JSPS, "Integrated
   Research on Neuropsychiatric Disorders" and "Bioinformatics for Brain
   Sciences" carried out under the SRPBS from MEXT, CREST, Grants-in-Aid
   for Scientific Research (24111518, 25116515, 25460093, 26670121,
   26293053) from the MEXT, Health and Labour Sciences Research Grant
   (H25-Iyaku-Ippan-020) from MHLW, Intramural Research Grant (24-12) for
   Neurological and Psychiatric Disorders of NCNP and SRF Grant for
   Biomedical Research.
CR Abi-Dargham A, 2002, J NEUROSCI, V22, P3708
   Allen DN, 2013, SCHIZOPHR RES, V146, P132, DOI 10.1016/j.schres.2013.01.032
   Austin CP, 2004, NEUROSCIENCE, V124, P3, DOI 10.1016/j.neuroscience.2003.11.010
   Austin CP, 2003, NEUROREPORT, V14, P951, DOI 10.1097/01.wnr.0000074342.81633.63
   Ayhan Y, 2011, MOL PSYCHIATR, V16, P293, DOI 10.1038/mp.2009.144
   Barr AM, 2004, NEUROPSYCHOPHARMACOL, V29, P221, DOI 10.1038/sj.npp.1300343
   BECKER JB, 1990, NEUROSCI LETT, V118, P169, DOI 10.1016/0304-3940(90)90618-J
   Belforte JE, 2010, NAT NEUROSCI, V13, P76, DOI 10.1038/nn.2447
   Blackwood DHR, 2001, AM J HUM GENET, V69, P428, DOI 10.1086/321969
   Blurton-Jones M, 2002, J COMP NEUROL, V452, P276, DOI 10.1002/cne.10393
   Bocklisch C, 2013, SCIENCE, V341, P1521, DOI 10.1126/science.1237059
   Brandon NJ, 2011, NAT REV NEUROSCI, V12, P707, DOI 10.1038/nrn3120
   Brebion G, 2013, SCHIZOPHR RES, V147, P81, DOI 10.1016/j.schres.2013.03.014
   Busatto GF, 1997, AM J PSYCHIAT, V154, P56
   Carlsson A, 2001, SCIENCE, V294, P1021, DOI 10.1126/science.1066969
   Castner SA, 2000, SCIENCE, V287, P2020, DOI 10.1126/science.287.5460.2020
   CASTNER SA, 1993, BRAIN RES, V610, P127, DOI 10.1016/0006-8993(93)91225-H
   Chattopadhyaya Bidisha, 2012, Front Psychiatry, V3, P51, DOI 10.3389/fpsyt.2012.00051
   Chen HH, 2003, CHINESE J PHYSIOL, V46, P169
   Chubb JE, 2008, MOL PSYCHIATR, V13, P36, DOI 10.1038/sj.mp.4002106
   Collins AL, 2006, NEUROGENETICS, V7, P167, DOI 10.1007/s10048-006-0045-1
   Devon RS, 2001, PSYCHIATR GENET, V11, P71, DOI 10.1097/00041444-200106000-00003
   Dichter GS, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-19
   Ekelund J, 2001, HUM MOL GENET, V10, P1611, DOI 10.1093/hmg/10.15.1611
   Enomoto A, 2009, NEURON, V63, P774, DOI 10.1016/j.neuron.2009.08.015
   Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3
   Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
   Fester L, 2011, CELL TISSUE RES, V345, P285, DOI 10.1007/s00441-011-1221-7
   Floresco SB, 2003, NAT NEUROSCI, V6, P968, DOI 10.1038/nn1103
   Ford C.P., 2014, NEUROSCIENC IN PRESS
   Franklin KBJ, 1997, MOUSE BRAIN STEREOTA, V1st
   FRIEDMAN WJ, 1991, EUR J NEUROSCI, V3, P688, DOI 10.1111/j.1460-9568.1991.tb00854.x
   Gilani AI, 2014, P NATL ACAD SCI USA, V111, P7450, DOI 10.1073/pnas.1316488111
   Girault JA, 2004, ARCH NEUROL-CHICAGO, V61, P641, DOI 10.1001/archneur.61.5.641
   Giros B, 1996, NATURE, V379, P606, DOI 10.1038/379606a0
   Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
   Guillin O, 2007, INT REV NEUROBIOL, V78, P1, DOI 10.1016/S0074-7742(06)78001-1
   HAFNER H, 1991, EUR ARCH PSY CLIN N, V241, P65, DOI 10.1007/BF02193758
   Hashimoto T, 2003, J NEUROSCI, V23, P6315
   Hennah W, 2005, MOL PSYCHIATR, V10, P1097, DOI 10.1038/sj.mp.4001731
   Hennah W, 2009, MOL PSYCHIATR, V14, P865, DOI 10.1038/mp.2008.22
   Hikida T, 2007, P NATL ACAD SCI USA, V104, P14501, DOI 10.1073/pnas.0704774104
   Hikida T, 2012, EXPERT OPIN THER TAR, V16, P1151, DOI 10.1517/14728222.2012.719879
   Hodgkinson CA, 2004, AM J HUM GENET, V75, P862, DOI 10.1086/425586
   Honda A, 2004, MOL BRAIN RES, V122, P89, DOI 10.1016/j.molbrainres.2003.11.020
   Hyman SE, 2006, ANNU REV NEUROSCI, V29, P565, DOI 10.1146/annurev.neuro.29.051605.113009
   Inan M, 2013, NEUROBIOL DIS, V53, P36, DOI 10.1016/j.nbd.2012.11.013
   Iversen SD, 2007, TRENDS NEUROSCI, V30, P188, DOI 10.1016/j.tins.2007.03.002
   Jaaro-Peled H, 2013, HUM MOL GENET, V22, P1574, DOI 10.1093/hmg/ddt007
   Jonas P, 2004, TRENDS NEUROSCI, V27, P30, DOI 10.1016/j.tins.2003.10.010
   Jones CA, 2011, BRIT J PHARMACOL, V164, P1162, DOI 10.1111/j.1476-5381.2011.01386.x
   Kamiya A, 2005, NAT CELL BIOL, V7, P1167, DOI 10.1038/ncb1328
   Karlsson P, 2002, AM J PSYCHIAT, V159, P761, DOI 10.1176/appi.ajp.159.5.761
   Kegeles LS, 2010, BIOL PSYCHIAT, V68, P634, DOI 10.1016/j.biopsych.2010.05.027
   Kellendonk C, 2006, NEURON, V49, P603, DOI 10.1016/j.neuron.2006.01.023
   Kilpinen H, 2008, MOL PSYCHIATR, V13, P187, DOI 10.1038/sj.mp.4002031
   Kim JY, 2012, CELL, V148, P1051, DOI 10.1016/j.cell.2011.12.037
   Kim JY, 2009, NEURON, V63, P761, DOI 10.1016/j.neuron.2009.08.008
   Konradi C, 2011, SCHIZOPHR RES, V131, P165, DOI 10.1016/j.schres.2011.06.007
   Korotkova T, 2010, NEURON, V68, P557, DOI 10.1016/j.neuron.2010.09.017
   Kritzer MF, 1999, J COMP NEUROL, V409, P438, DOI 10.1002/(SICI)1096-9861(19990705)409:3<438::AID-CNE8>3.0.CO;2-5
   Kuroda K, 2011, HUM MOL GENET, V20, P4666, DOI 10.1093/hmg/ddr400
   Laviolette SR, 2007, SCHIZOPHRENIA BULL, V33, P971, DOI 10.1093/schbul/sbm048
   Lee F.H., 2013, MOL BRAIN, V6
   Legault M, 2000, J NEUROSCI, V20, P1635
   Leung A, 2000, ACTA PSYCHIAT SCAND, V101, P3
   Lewis DA, 2008, NEUROPSYCHOPHARMACOL, V33, P141, DOI 10.1038/sj.npp.1301563
   Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
   Lipina TV, 2010, GENES BRAIN BEHAV, V9, P777, DOI 10.1111/j.1601-183X.2010.00615.x
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lodge DJ, 2011, TRENDS PHARMACOL SCI, V32, P507, DOI 10.1016/j.tips.2011.05.001
   Ma L, 2002, GENOMICS, V80, P662, DOI 10.1006/geno.2002.7012
   Mao YW, 2009, CELL, V136, P1017, DOI 10.1016/j.cell.2008.12.044
   Millar JK, 2005, SCIENCE, V310, P1187, DOI 10.1126/science.1112915
   Millar JK, 2000, HUM MOL GENET, V9, P1415, DOI 10.1093/hmg/9.9.1415
   Miyoshi K, 2003, MOL PSYCHIATR, V8, P685, DOI 10.1038/sj.mp.4001352
   Mouri A, 2013, NEUROBIOL DIS, V53, P61, DOI 10.1016/j.nbd.2012.10.025
   Nagai T, 2010, NEUROSCI LETT, V470, P134, DOI 10.1016/j.neulet.2009.12.071
   Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
   Niwa M, 2010, NEURON, V65, P480, DOI 10.1016/j.neuron.2010.01.019
   Oblak AL, 2010, J NEUROCHEM, V114, P1414, DOI 10.1111/j.1471-4159.2010.06858.x
   Okubo Y, 1997, NATURE, V385, P634, DOI 10.1038/385634a0
   Pillai A, 2008, NEUROSIGNALS, V16, P183, DOI 10.1159/000111562
   Pletnikov M V, 2008, Mol Psychiatry, V13, P115, DOI 10.1038/sj.mp.4002144
   Pogorelov VM, 2012, NEUROPHARMACOLOGY, V62, P1242, DOI 10.1016/j.neuropharm.2011.02.003
   Rune GM, 2006, NEUROCHEM RES, V31, P145, DOI 10.1007/s11064-005-9004-8
   Sanchez MG, 2010, CNS NEUROSCI THER, V16, pe43, DOI 10.1111/j.1755-5949.2010.00163.x
   Schumacher J, 2009, HUM MOL GENET, V18, P2719, DOI 10.1093/hmg/ddp204
   Seeman P, 2011, CNS NEUROSCI THER, V17, P118, DOI 10.1111/j.1755-5949.2010.00162.x
   Shen SB, 2008, J NEUROSCI, V28, P10893, DOI 10.1523/JNEUROSCI.3299-08.2008
   Shinoda T, 2007, J NEUROSCI, V27, P4, DOI 10.1523/JNEUROSCI.3825-06.2007
   Singh KK, 2010, NEURON, V67, P33, DOI 10.1016/j.neuron.2010.06.002
   STCLAIR D, 1990, LANCET, V336, P13, DOI 10.1016/0140-6736(90)91520-K
   Streinecke A., 2012, J NEUROSCI, V32, P738
   Sun MK, 2006, J PHARMACOL EXP THER, V316, P926, DOI 10.1124/jpet.105.093948
   Surmeier DJ, 2010, PROG BRAIN RES, V183, P149, DOI 10.1016/S0079-6123(10)83008-0
   Swanson JM, 2007, NEUROPSYCHOL REV, V17, P39, DOI 10.1007/s11065-007-9019-9
   Taya S, 2007, J NEUROSCI, V27, P15, DOI 10.1523/JNEUROSCI.3826-06.2006
   Weickert CS, 2003, MOL PSYCHIATR, V8, P592, DOI 10.1038/sj.mp.4001308
   WEILAND NG, 1992, ENDOCRINOLOGY, V131, P2697, DOI 10.1210/en.131.6.2697
   Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
NR 101
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD JUL
PY 2014
VL 74
BP 74
EP 83
DI 10.1016/j.neuint.2014.06.009
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AN0YJ
UT WOS:000340309600010
PM 24973713
ER

PT J
AU Jenkins, TG
   Aston, KI
   Pflueger, C
   Cairns, BR
   Carrell, DT
AF Jenkins, Timothy G.
   Aston, Kenneth I.
   Pflueger, Christian
   Cairns, Bradley R.
   Carrell, Douglas T.
TI Age-Associated Sperm DNA Methylation Alterations: Possible Implications
   in Offspring Disease Susceptibility
SO PLOS GENETICS
LA English
DT Article
ID PARENTAL AGE; PATERNAL AGE; HUNTINGTONS-DISEASE; CHILDHOOD LEUKEMIA;
   BIPOLAR DISORDER; TELOMERE LENGTH; TNXB LOCUS; GENE; SCHIZOPHRENIA; SEX
AB Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy, Huntington's, etc.) and even some forms of cancer have increased incidence in the offspring of older fathers. Despite strong epidemiological evidence that these alterations are more common in offspring sired by older fathers, in most cases the mechanisms that drive these processes are unclear. However, it is commonly believed that epigenetics, and specifically DNA methylation alterations, likely play a role. In this study we have investigated the impact of aging on DNA methylation in mature human sperm. Using a methylation array approach we evaluated changes to sperm DNA methylation patterns in 17 fertile donors by comparing the sperm methylome of 2 samples collected from each individual 9-19 years apart. With this design we have identified 139 regions that are significantly and consistently hypomethylated with age and 8 regions that are significantly hypermethylated with age. A representative subset of these alterations have been confirmed in an independent cohort. A total of 117 genes are associated with these regions of methylation alterations (promoter or gene body). Intriguingly, a portion of the age-related changes in sperm DNA methylation are located at genes previously associated with schizophrenia and bipolar disorder. While our data does not establish a causative relationship, it does raise the possibility that the age-associated methylation of the candidate genes that we observe in sperm might contribute to the increased incidence of neuropsychiatric and other disorders in the offspring of older males. However, further study is required to determine whether, and to what extent, a causative relationship exists.
C1 [Jenkins, Timothy G.; Aston, Kenneth I.; Carrell, Douglas T.] Univ Utah, Sch Med, Dept Surg, Androl & IVF Labs, Salt Lake City, UT 84112 USA.
   [Pflueger, Christian; Cairns, Bradley R.] Univ Utah, Sch Med, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT USA.
   [Cairns, Bradley R.] Howard Hughes Med Inst, Chevy Chase, MD USA.
   [Carrell, Douglas T.] Univ Utah, Sch Med, Dept Genet, Salt Lake City, UT USA.
   [Carrell, Douglas T.] Univ Utah, Sch Med, Dept Obstet & Gynecol, Salt Lake City, UT 84132 USA.
RP Jenkins, TG (reprint author), Univ Utah, Sch Med, Dept Surg, Androl & IVF Labs, Salt Lake City, UT 84112 USA.
EM Brad.Cairns@hci.utah.edu; douglas.carrell@hsc.utah.edu
FU University of Utah Center on Aging
FX An internal University of Utah small grant from the "University of Utah
   Center on Aging" was used for this study. Additionally, clinical funds
   were used for this study. No outside grant agency funds were applied.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR ALLSOPP RC, 1992, P NATL ACAD SCI USA, V89, P10114, DOI 10.1073/pnas.89.21.10114
   ANDREW SE, 1993, NAT GENET, V4, P398, DOI 10.1038/ng0893-398
   Arpanahi A, 2009, GENOME RES, V19, P1338, DOI 10.1101/gr.094953.109
   Boissonnas CC, 2010, EUR J HUM GENET, V18, P73, DOI 10.1038/ejhg.2009.117
   BRUNNER HG, 1993, AM J HUM GENET, V53, P1016
   Carone BR, 2010, CELL, V143, P1084, DOI 10.1016/j.cell.2010.12.008
   Christensen BC, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000602
   Day K., 2013, SDFG, V14, pR102, DOI DOI 10.1186/GB-2013-14-9-R102
   Deroo LA, 2013, CARCINOGENESIS, V35, P333
   Erkek S, 2013, NAT STRUCT MOL BIOL, V20, P868, DOI 10.1038/nsmb.2599
   Frans EM, 2008, ARCH GEN PSYCHIAT, V65, P1034, DOI 10.1001/archpsyc.65.9.1034
   GOLDBERG YP, 1993, NAT GENET, V5, P174, DOI 10.1038/ng1093-174
   Gorbunova V, 2004, HUM MOL GENET, V13, P2979, DOI 10.1093/hmg/ddh317
   Goriely A, 2012, AM J HUM GENET, V90, P175, DOI 10.1016/j.ajhg.2011.12.017
   Hammoud SS, 2009, NATURE, V460, P473, DOI 10.1038/nature08162
   HARE EH, 1979, BRIT J PSYCHIAT, V134, P169, DOI 10.1192/bjp.134.2.169
   Hemminki K, 1999, EPIDEMIOLOGY, V10, P271, DOI 10.1097/00001648-199905000-00014
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Jenkins TG, 2013, FERTIL STERIL, V100, P945, DOI 10.1016/j.fertnstert.2013.05.039
   Kaati G, 2007, EUR J HUM GENET, V15, P784, DOI 10.1038/sj.ejhg.5201832
   Kreimer Ulrike, 2013, Front Oncol, V3, P255, DOI 10.3389/fonc.2013.00255
   Lung FW, 2002, SCHIZOPHR RES, V57, P239, DOI 10.1016/S0920-9964(01)00313-9
   Miller B, 2011, SCHIZOPHRENIA BULL, V37, P1039, DOI 10.1093/schbul/sbq011
   Murray L, 2002, BRIT J CANCER, V86, P356, DOI 10.1038/sj/bjc/6600012
   Nanassy L, 2011, ASIAN J ANDROL, V13, P342, DOI 10.1038/aja.2010.160
   Njajou OT, 2007, P NATL ACAD SCI USA, V104, P12135, DOI 10.1073/pnas.0702703104
   Oksuzyan S, 2012, CANCER EPIDEMIOL, V36, pE359, DOI 10.1016/j.canep.2012.08.002
   Paul C, 2013, NAT REV UROL, V10, P227, DOI 10.1038/nrurol.2013.18
   Pembrey ME, 2006, EUR J HUM GENET, V14, P159, DOI 10.1038/sj.ejhg.5204538
   Richardson B, 2003, AGEING RES REV, V2, P245, DOI 10.1016/S1568-1637(03)00010-2
   Serretti A, 2008, MOL PSYCHIATR, V13, P742, DOI 10.1038/mp.2008.29
   Thompson RF, 2010, AGING CELL, V9, P506, DOI 10.1111/j.1474-9726.2010.00577.x
   Tochigi M, 2007, AM J MED GENET B, V144B, P305, DOI 10.1002/ajmg.b.30441
   Unryn BM, 2005, AGING CELL, V4, P97, DOI 10.1111/j.1474-9728.2005.00144.x
   Wei J, 2004, AM J MED GENET B, V125B, P43, DOI 10.1002/ajmg.b.20093
   Yip BH, 2006, INT J EPIDEMIOL, V35, P1495, DOI 10.1093/ije/dyl177
   ZHENG CJ, 1993, P NATL ACAD SCI USA, V90, P10178, DOI 10.1073/pnas.90.21.10178
NR 37
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD JUL
PY 2014
VL 10
IS 7
AR e1004458
DI 10.1371/journal.pgen.1004458
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA AM5ME
UT WOS:000339902600016
PM 25010591
ER

PT J
AU Tulgren, ED
   Turgeon, SM
   Opperman, KJ
   Grill, B
AF Tulgren, Erik D.
   Turgeon, Shane M.
   Opperman, Karla J.
   Grill, Brock
TI The Nesprin Family Member ANC-1 Regulates Synapse Formation and Axon
   Termination by Functioning in a Pathway with RPM-1 and beta-Catenin
SO PLOS GENETICS
LA English
DT Article
ID UBIQUITIN LIGASE RPM-1; MAP KINASE PATHWAY; C-ELEGANS RPM-1;
   CAENORHABDITIS-ELEGANS; NUCLEAR-ENVELOPE; WNT PATHWAY;
   NEUROMUSCULAR-JUNCTION; GLUTAMATE RECEPTORS; NEURONAL MIGRATION; NEURITE
   OUTGROWTH
AB Mutations in Nesprin-1 and 2 (also called Syne-1 and 2) are associated with numerous diseases including autism, cerebellar ataxia, cancer, and Emery-Dreifuss muscular dystrophy. Nesprin-1 and 2 have conserved orthologs in flies and worms called MSP-300 and abnormal nuclear Anchorage 1 (ANC-1), respectively. The Nesprin protein family mediates nuclear and organelle anchorage and positioning. In the nervous system, the only known function of Nesprin-1 and 2 is in regulation of neurogenesis and neural migration. It remains unclear if Nesprin-1 and 2 regulate other functions in neurons. Using a proteomic approach in C. elegans, we have found that ANC-1 binds to the Regulator of Presynaptic Morphology 1 (RPM-1). RPM-1 is part of a conserved family of signaling molecules called Pam/Highwire/RPM-1 (PHR) proteins that are important regulators of neuronal development. We have found that ANC-1, like RPM-1, regulates axon termination and synapse formation. Our genetic analysis indicates that ANC-1 functions via the beta-catenin BAR-1, and the ANC-1/BAR-1 pathway functions cell autonomously, downstream of RPM-1 to regulate neuronal development. Further, ANC-1 binding to the nucleus is required for its function in axon termination and synapse formation. We identify variable roles for four different Wnts (LIN-44, EGL-20, CWN-1 and CWN-2) that function through BAR-1 to regulate axon termination. Our study highlights an emerging, broad role for ANC-1 in neuronal development, and unveils a new and unexpected mechanism by which RPM-1 functions.
C1 [Tulgren, Erik D.] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA.
   [Turgeon, Shane M.; Opperman, Karla J.; Grill, Brock] Scripps Res Inst Florida, Dept Neurosci, Jupiter, FL USA.
RP Tulgren, ED (reprint author), Univ Minnesota, Dept Pharmacol, 3-249 Millard Hall, Minneapolis, MN 55455 USA.
EM bgrill@scripps.edu
FU NIH [R01 NS072129]; NSF [IOS-1121095]
FX BG was supported by the NIH (R01 NS072129) and the NSF (IOS-1121095).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Abrams B, 2008, DEV DYNAM, V237, P630, DOI 10.1002/dvdy.21446
   Andreassen OA, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003455
   Apel ED, 2000, J BIOL CHEM, V275, P31986, DOI 10.1074/jbc.M004775200
   Attali R, 2009, HUM MOL GENET, V18, P3462, DOI 10.1093/hmg/ddp290
   Babetto E, 2013, CELL REP, V3, P1422, DOI 10.1016/j.celrep.2013.04.013
   Baker ST, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004297
   Bamji SX, 2003, NEURON, V40, P719, DOI 10.1016/S0896-6273(03)00718-9
   Bloom AJ, 2007, GENE DEV, V21, P2593, DOI 10.1101/gad.1592107
   Burgess RW, 2004, MOL CELL BIOL, V24, P1096, DOI 10.1128/MCB.24.3.1096-1105.2004
   CHALFIE M, 1979, J CELL BIOL, V82, P278, DOI 10.1083/jcb.82.1.278
   Ch'ng' Q, 2003, GENETICS, V164, P1355
   Clevers H, 2012, CELL, V149, P1192, DOI 10.1016/j.cell.2012.05.012
   Collins CA, 2006, NEURON, V51, P57, DOI 10.1016/j.neuron.2006.05.026
   Cottrell JR, 2004, NEURON, V44, P677, DOI 10.1016/S0896-6273(04)00688-9
   Del Bene F, 2008, CELL, V134, P1055, DOI 10.1016/j.cell.2008.07.017
   Dreier L, 2005, NEURON, V46, P51, DOI 10.1016/j.neuron.2004.12.058
   D'Souza J, 2005, DEVELOPMENT, V132, P247, DOI 10.1242/dev.01578
   Ehnert C, 2004, J NEUROCHEM, V88, P948
   Eisenmann DM, 1998, DEVELOPMENT, V125, P3667
   Elhanany-Tamir H, 2012, J CELL BIOL, V198, P833, DOI 10.1083/jcb.201204102
   Elul TM, 2003, J NEUROSCI, V23, P6567
   Gough LL, 2004, BBA-MOL CELL RES, V1693, P29, DOI 10.1016/j.bbamcr.2004.04.004
   Grady RM, 2005, P NATL ACAD SCI USA, V102, P4359, DOI 10.1073/pnas.0500711102
   Green EK, 2013, MOL PSYCHIATR, V18, P614, DOI 10.1038/mp.2012.48
   Grill B, 2007, NEURON, V55, P587, DOI 10.1016/j.neuron.2007.07.009
   Grill B, 2012, J NEUROSCI, V32, P2628, DOI 10.1523/JNEUROSCI.2901-11.2012
   Gros-Louis F, 2007, NAT GENET, V39, P80, DOI 10.1038/ng1927
   Haithcock E, 2005, P NATL ACAD SCI USA, V102, P16690, DOI 10.1073/pnas.0506755102
   Hallam SJ, 1998, NATURE, V395, P78, DOI 10.1038/25757
   Hammarlund M, 2009, SCIENCE, V323, P802, DOI 10.1126/science.1165527
   Harterink M, 2011, DEVELOPMENT, V138, P2915, DOI 10.1242/dev.064733
   Hendricks M, 2008, MOL CELL NEUROSCI, V37, P271, DOI 10.1016/j.mcn.2007.10.002
   Hilliard MA, 2006, DEV CELL, V10, P379, DOI 10.1016/j.devcel.2006.01.013
   Hung WL, 2013, EMBO J, V32, P1745, DOI 10.1038/emboj.2013.91
   Jackson BM, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a007948
   Kennerdell JR, 2009, DEVELOPMENT, V136, P3801, DOI 10.1242/dev.038109
   Kidd AR, 2005, CELL, V121, P761, DOI 10.1016/j.cell.2005.03.029
   Kim JH, 2013, NEURON, V78, P827, DOI 10.1016/j.neuron.2013.05.020
   Kirszenblat L, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001157
   Korswagen HC, 2002, GENE DEV, V16, P1291, DOI 10.1101/gad.981802
   Korswagen HC, 2000, NATURE, V406, P527, DOI 10.1038/35020099
   Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453
   Lewcock JW, 2007, NEURON, V56, P604, DOI 10.1016/j.neuron.2007.09.009
   Li HL, 2008, IEEE POTENTIALS, V27, P5, DOI 10.1109/MPOT.2008.923296
   Li XM, 2008, NAT NEUROSCI, V11, P262, DOI 10.1038/nn2053
   Liao EH, 2004, NATURE, V430, P345, DOI 10.1038/nature02647
   Libotte T, 2005, MOL BIOL CELL, V16, P3411, DOI 10.1091/mbc.E04-11-1009
   Lo MC, 2004, CELL, V117, P95, DOI 10.1016/S0092-8674(04)00203-X
   Luxton GWG, 2010, SCIENCE, V329, P956, DOI 10.1126/science.1189072
   Malone CJ, 1999, DEVELOPMENT, V126, P3171
   Markiewicz E, 2006, EMBO J, V25, P3275, DOI 10.1038/sj.emboj.7601230
   Maro GS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004690
   McCabe BD, 2004, NEURON, V41, P891, DOI 10.1016/S0896-6273(04)00073-X
   Mehta N, 2004, GENETICS, V166, P1253, DOI 10.1534/genetics.166.3.1253
   Murase S, 2002, NEURON, V35, P91, DOI 10.1016/S0896-6273(02)00764-X
   Murthy V, 2004, J BIOL CHEM, V279, P1351, DOI 10.1074/jbc.M310208200
   Nakata K, 2005, CELL, V120, P407, DOI 10.1016/j.cell.2004.12.017
   Neumann S, 2010, J BIOL CHEM, V285, P34932, DOI 10.1074/jbc.M110.119651
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pan CL, 2006, DEV CELL, V10, P367, DOI 10.1016/j.devcel.2006.02.010
   Park EC, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004284
   Phillips BT, 2009, DEV CELL, V17, P27, DOI 10.1016/j.devcel.2009.07.002
   Po MD, 2010, CURR OPIN NEUROBIOL, V20, P100, DOI 10.1016/j.conb.2009.12.007
   Prasad BC, 2006, DEVELOPMENT, V133, P1757, DOI 10.1242/dev.02357
   Puckelwartz MJ, 2010, J MOL CELL CARDIOL, V48, P600, DOI 10.1016/j.yjmcc.2009.11.006
   Rocheleau CE, 1997, CELL, V90, P707, DOI 10.1016/S0092-8674(00)80531-0
   Santos TM, 2006, J NEUROSCI RES, V83, P222, DOI 10.1002/jnr.20723
   Schaefer AM, 2000, NEURON, V26, P345, DOI 10.1016/S0896-6273(00)81168-X
   Shen K, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a001842
   Siegfried KR, 2002, DEVELOPMENT, V129, P443
   Sklar P, 2011, NAT GENET, V43, P977, DOI 10.1038/ng.943
   Starr DA, 2010, ANNU REV CELL DEV BI, V26, P421, DOI 10.1146/annurev-cellbio-100109-104037
   Starr DA, 2002, SCIENCE, V298, P406, DOI 10.1126/science1075119
   Tessema M, 2008, CANCER RES, V68, P1707, DOI 10.1158/0008-5472.CAN-07-6325
   Tian XL, 2011, NAT NEUROSCI, V14, P1267, DOI 10.1038/nn.2922
   Vashlishan AB, 2008, NEURON, V58, P346, DOI 10.1016/j.neuron.2008.02.019
   Votin V, 2005, J CELL SCI, V118, P5699, DOI 10.1242/jcs.02679
   Wan HI, 2000, NEURON, V26, P313, DOI 10.1016/S0896-6273(00)81166-6
   Warren DT, 2010, J BIOL CHEM, V285, P1311, DOI 10.1074/jbc.M109.032557
   Xiong X, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001440
   Xiong X, 2010, J CELL BIOL, V191, P211, DOI 10.1083/jcb.201006039
   Yochem J, 1998, GENETICS, V149, P1323
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Yu X, 2003, NAT NEUROSCI, V6, P1169, DOI 10.1038/nn1132
   Zechner D, 2003, DEV BIOL, V258, P406, DOI 10.1016/S0012-1606(03)00123-4
   Zhang QP, 2005, J CELL SCI, V118, P673, DOI 10.1242/jcs.016242
   Zhang QP, 2007, HUM MOL GENET, V16, P2816, DOI 10.1093/hmg/ddm238
   Zhang XC, 2007, DEVELOPMENT, V134, P901, DOI 10.1242/dev.02783
   Zhang XC, 2009, NEURON, V64, P173, DOI 10.1016/j.neuron.2009.08.018
   Zhen M, 2000, NEURON, V26, P331, DOI 10.1016/S0896-6273(00)81167-8
NR 90
TC 6
Z9 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD JUL
PY 2014
VL 10
IS 7
AR e1004481
DI 10.1371/journal.pgen.1004481
PG 16
WC Genetics & Heredity
SC Genetics & Heredity
GA AM5ME
UT WOS:000339902600033
PM 25010424
ER

PT J
AU St Peter, CC
   Brunson, LY
   Cook, JE
   Subramaniam, S
   Larson, NA
   Clingan, M
   Poe, SG
AF St Peter, Claire C.
   Brunson, Lashanna Y.
   Cook, James E.
   Subramaniam, Shrinidhi
   Larson, Nicholas A.
   Clingan, Mark
   Poe, Susannah G.
TI ADHERENCE TO DISCRETE-TRIAL INSTRUCTION PROCEDURES BY RURAL PARENTS OF
   CHILDREN WITH AUTISM
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID TEACHING SKILLS; DRUG-THERAPY; STAFF; IMPLEMENTATION; INTERVENTION;
   ASSESSMENTS; ACQUISITION; PERFORMANCE; PREFERENCE; BEHAVIOR
AB Parents of children with autism spectrum disorders may not attempt treatment, even when effective treatment options are available. Little is known about how to improve frequency of attempts to implement treatment ('treatment adherence'). We provided 32 rural parents of young children with autism spectrum disorders with either written or video training materials about how to implement discrete-trial instruction and compared parental adherence between the written (control) and video (experimental) groups. Parents who received video instructions adhered to the training procedures to a significantly greater extent than did parents who received written instructions, suggesting that instruction format is a predictor of training success. Copyright (C) 2014 John Wiley & Sons, Ltd.
C1 [St Peter, Claire C.; Cook, James E.; Subramaniam, Shrinidhi] W Virginia Univ, Dept Psychol, Morgantown, WV 26506 USA.
   [Brunson, Lashanna Y.; Larson, Nicholas A.; Clingan, Mark; Poe, Susannah G.] W Virginia Univ, Ctr Excellence Disabil, Morgantown, WV 26505 USA.
RP St Peter, CC (reprint author), W Virginia Univ, Dept Psychol, POB 6040, Morgantown, WV 26506 USA.
EM Claire.StPeter@mail.wvu.edu
CR Ahearn W. H., 2013, APA HDB BEHAV ANAL, V2, P301
   Allen KD, 2000, J APPL BEHAV ANAL, V33, P373, DOI 10.1901/jaba.2000.33-373
   ARMBRUSTER P, 1994, ADV CLIN CHILD PSYCH, V16, P81
   Arnal L., 2007, DEV DISABILITIES B, V35, P131
   Barretro A, 2006, J APPL BEHAV ANAL, V39, P333, DOI 10.1901/jaba.2006.173-04
   Bernal M. E., 1984, PARENT TRAINING FDN, P477
   Brown I, 2009, EPILEPSY BEHAV, V16, P634, DOI 10.1016/j.yebeh.2009.09.014
   Catania CN, 2009, J APPL BEHAV ANAL, V42, P387, DOI 10.1901/jaba.2009.42-387
   Crockett JL, 2007, RES DEV DISABIL, V28, P23, DOI 10.1016/j.ridd.2005.10.003
   DiGennaro Reed F. D., 2010, J APPL BEHAV ANAL, V43, P291, DOI [10.1901/jaba.2010.43-291, DOI 10.1901/JABA.2010.43-291]
   Faught E, 2012, EPILEPSY BEHAV, V25, P297, DOI 10.1016/j.yebeh.2012.08.027
   Frueh BC, 2007, BEHAV MODIF, V31, P856, DOI 10.1177/0145445507302125
   Gance-Cleveland Bonnie, 2005, J Spec Pediatr Nurs, V10, P151, DOI 10.1111/j.1744-6155.2005.00028.x
   Green G, 1996, BEHAV INTERVENTION Y, P29
   Hay-Hansson AW, 2013, RES AUTISM SPECT DIS, V7, P1300, DOI 10.1016/j.rasd.2013.07.022
   IWATA BA, 1976, J APPL BEHAV ANAL, V9, P417, DOI 10.1901/jaba.1976.9-417
   Jarmolowicz DP, 2008, INTELLECT DEV DISAB, V46, P190, DOI 10.1352/2008.46:190-199
   KOEGEL RL, 1978, J APPL BEHAV ANAL, V11, P95, DOI 10.1901/jaba.1978.11-95
   Lafasakis M, 2007, J APPL BEHAV ANAL, V40, P685, DOI 10.1901/jaba.2007.685-689
   Lerman DC, 2000, RES DEV DISABIL, V21, P183, DOI 10.1016/S0891-4222(00)00033-0
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Moore TR, 2011, BEHAV MODIF, V35, P570, DOI 10.1177/0145445511418103
   Moore TR, 2009, J AUTISM DEV DISORD, V39, P1173, DOI 10.1007/s10803-009-0729-0
   MUIR KA, 1982, J APPL BEHAV ANAL, V15, P455, DOI 10.1901/jaba.1982.15-455
   National Telecommunications & Information Administration, 2013, US BROADB AV JUN 201
   Nock MK, 2005, J CONSULT CLIN PSYCH, V73, P872, DOI 10.1037/0022-006X.73.5.872
   Osterberg L, 2005, NEW ENGL J MED, V353, P487, DOI 10.1056/NEJMra050100
   Roscoe EM, 2006, J APPL BEHAV ANAL, V39, P63, DOI 10.1901/jaba.2006.7-05
   Sampaio-Sa M, 2008, AIDS BEHAV, V12, pS54, DOI 10.1007/s10461-008-9414-0
   Severtson Jamie M, 2012, Behav Anal Pract, V5, P13
   Smith T., 2001, FOCUS AUTISM OTHER D, V16, P86, DOI 10.1177/108835760101600204
   Thiessen C, 2009, BEHAV MODIF, V33, P360, DOI 10.1177/0145445508327443
   Thomson K, 2009, RES AUTISM SPECT DIS, V3, P590, DOI 10.1016/j.rasd.2009.01.003
   Vladescu JC, 2012, J APPL BEHAV ANAL, V45, P419, DOI 10.1901/jaba.2012.45-419
   Wacker DP, 2013, J DEV PHYS DISABIL, V25, P35, DOI 10.1007/s10882-012-9314-0
   Williams WL, 2011, J ORGAN BEHAV MANAGE, V31, P97, DOI 10.1080/01608061.2011.570099
NR 36
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1072-0847
EI 1099-078X
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD JUL
PY 2014
VL 29
IS 3
BP 200
EP 212
DI 10.1002/bin.1386
PG 13
WC Psychology, Clinical
SC Psychology
GA AM6EG
UT WOS:000339955100003
ER

PT J
AU Guercio, JM
   Murray, WJ
AF Guercio, John M.
   Murray, William J.
TI LICENSURE FOR BEHAVIOR ANALYSTS: THE PATH TO RESPONSIBLE AND COOPERATIVE
   ACTION
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID CHILDREN; AUTISM; DISORDER
AB The increase in the prevalence of autism spectrum disorders in the last decade has contributed to growth in the field of applied behavior analysis (ABA). This growth has been spurred by consumer demand for access to this evidence-based treatment for those with an autism spectrum disorder. Presently, there are at least 34 states that have laws or regulations in place that mandate insurance coverage for autism spectrum disorders. There are also 14 states that have passed licensure or a similar regulatory mechanism for identifying competent providers of ABA. The following paper documents the process of insuring consumer advocacy and protection in the states of Missouri and Wisconsin through the passage of legislation that established licensure for practitioners of ABA. The evolution of this process in both of these states will be detailed as well as a number of lessons learned that should prove to be helpful as additional states move toward licensure for practitioners of ABA. Copyright (C) 2014 John Wiley & Sons, Ltd.
C1 [Guercio, John M.] Missouri Assoc Behav Anal, St Louis, MO USA.
   [Murray, William J.] Wisconsin Assoc Behav Anal, Madison, WI USA.
RP Guercio, JM (reprint author), AWS, 1215 Fern Ridge Pkwy Ste 204, St Louis, MO 63141 USA.
EM jguercio@gtec.com
CR Austin J., 2000, HDB APPL BEHAV ANAL, P321
   Bailey J., 2010, MULTISTATE DISCUSSIO
   Chasson G. S., 2007, J CHILD FAM STUD, V16, P401, DOI DOI 10.1007/S10826-006-9094-1
   Dorsey Michael F, 2009, Behav Anal Pract, V2, P53
   Eldevik S, 2012, J AUTISM DEV DISORD, V42, P210, DOI 10.1007/s10803-011-1234-9
   Eldevik S, 2006, J AUTISM DEV DISORD, V36, P211, DOI 10.1007/s10803-005-0058-x
   Ericsson K. A., 2004, ACAD MED S, V19, P70
   Green Gina, 2009, Behav Anal Pract, V2, P59
   Guercio JM, 2011, J ORGAN BEHAV MANAGE, V31, P43, DOI 10.1080/01608061.2010.520142
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   MCEACHIN JJ, 1993, AM J MENT RETARD, V97, P359
   New York State Department of Health, 1999, CLIN PRACT GUID REP
   Reichow B, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001572
   Reid DH, 1996, J ORGAN BEHAV MANAGE, V16, P35
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Shook G. L., 2009, BEHAV ANAL CERTIFICA, P1
   Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
   Vanderkerken L, 2013, RES DEV DISABIL, V34, P4515, DOI 10.1016/j.ridd.2013.09.030
NR 18
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1072-0847
EI 1099-078X
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD JUL
PY 2014
VL 29
IS 3
BP 225
EP 240
DI 10.1002/bin.1388
PG 16
WC Psychology, Clinical
SC Psychology
GA AM6EG
UT WOS:000339955100005
ER

PT J
AU Wetie, AGN
   Wormwood, K
   Thome, J
   Dudley, E
   Taurines, R
   Gerlach, M
   Woods, AG
   Darie, CC
AF Wetie, Armand G. Ngounou
   Wormwood, Kelly
   Thome, Johannes
   Dudley, Edward
   Taurines, Regina
   Gerlach, Manfred
   Woods, Alisa G.
   Darie, Costel C.
TI A pilot proteomic study of protein markers in autism spectrum disorder
SO ELECTROPHORESIS
LA English
DT Article
DE Apolipoprotein; ASD; Autism; Biomarkers; Cholesterol; Oxidative stress
ID APOLIPOPROTEIN-A-IV; INTENSIVE BEHAVIORAL INTERVENTION; EXPANDED FMR1
   ALLELES; LEMLI-OPITZ-SYNDROME; INTRON 1 METHYLATION; DE-NOVO MUTATIONS;
   MASS-SPECTROMETRY; CEREBROSPINAL-FLUID; MENTAL-RETARDATION; FEMALE
   CARRIERS
AB Autism spectrum disorder (ASD) diagnosis is increasing, with 1/88 children believed to be affected by the disorder, with a most recent survey suggesting numbers as high as 1/50. Treatment and understanding of ASD causes is a pressing health concern. ASD protein biomarkers may provide clues about ASD cause. Protein biomarkers for ASDs could be used for ASD diagnosis, subtyping, treatment monitoring, and identifying therapeutic targets. Here, we analyzed the sera from seven children with ASD and seven matched controls using Tricine gel electrophoresis (Tricine-PAGE) and LC-MS/MS. Overall, we found increased levels of apolipoproteins ApoA1 and ApoA4, involved in cholesterol metabolism and of serum paraoxanase/arylesterase 1, involved in preventing oxidative damage, in the sera of children with ASD, compared with their matched controls. All three proteins are predicted to interact with each other and are parts of high-density lipoproteins. Further studies are needed to validate these findings in larger subject numbers.
C1 [Wetie, Armand G. Ngounou; Wormwood, Kelly; Woods, Alisa G.; Darie, Costel C.] Clarkson Univ, Dept Chem & Biomol Sci, Biochem & Prote Grp, Potsdam, NY 13699 USA.
   [Thome, Johannes] Univ Rostock, Dept Psychiat, D-18055 Rostock, Germany.
   [Thome, Johannes; Dudley, Edward] Swansea Univ, Coll Med, Swansea, W Glam, Wales.
   [Taurines, Regina; Gerlach, Manfred] Univ Wurzburg, Dept Child & Adolescent Psychiat, Wurzburg, Germany.
RP Darie, CC (reprint author), Clarkson Univ, Dept Chem & Biomol Sci, Biochem & Prote Grp, 8 Clarkson Ave, Potsdam, NY 13699 USA.
EM cdarie@clarkson.edu
FU U.S./Army Research Office (DURIP) [W911NF-11-1-0304]; David A. Walsh '67
   Fellowship
FX We thank Mr. Tobias Ternent (PRIDE Team) for support in submission of
   the mass spectrometry data to the ProteomeX-change Consortium via the
   PRIDE repository. This work was supported partially by the U.S./Army
   Research Office (DURIP grant #W911NF-11-1-0304 to C.C.D.), private
   donations, the Alexander von Humboldt Foundation (A.G.W.) and the
   generosity of SciFund Challenge-3 donors. KLW and CCD were supported
   during the Summer 2013 by the David A. Walsh '67 Fellowship.
CR AKERLOF E, 1991, BIOCHEMISTRY-US, V30, P8986
   Aneja A, 2008, INT REV PSYCHIATR, V20, P165, DOI 10.1080/09540260801889062
   Autism I., 2012, MMWR SURVEILL SUMM, V61, P1
   Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
   Conciatori M, 2004, BIOL PSYCHIAT, V55, P413, DOI 10.1016/j.biopsych.2003.10.005
   Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
   Costa LG, 2011, BIOCHEM PHARMACOL, V81, P337, DOI 10.1016/j.bcp.2010.11.008
   Cote RG, 2012, MOL CELL PROTEOMICS, V11, P1682, DOI 10.1074/mcp.O112.021543
   Darie CC, 2011, PROTEOMICS, V11, P4514, DOI 10.1002/pmic.201000819
   Darie CC, 2005, FEBS J, V272, P2705, DOI 10.1111/j.1742-4658.2005.04685.x
   Dawson G, 2010, CURR OPIN NEUROL, V23, P95, DOI 10.1097/WCO.0b013e3283377644
   Della Donna L, 2012, COMP BIOCHEM PHYS D, V7, P9, DOI 10.1016/j.cbd.2011.10.001
   Dereu M, 2012, EUR CHILD ADOLES PSY, V21, P541, DOI 10.1007/s00787-012-0280-y
   Eikeseth S, 2012, RES AUTISM SPECT DIS, V6, P829, DOI 10.1016/j.rasd.2011.09.002
   El-Ansary A, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-160
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   Fujii Hidehiko, 2002, J Atheroscler Thromb, V9, P93
   FURLONG CE, 1993, CHEM-BIOL INTERACT, V87, P35, DOI 10.1016/0009-2797(93)90023-R
   Ghanizadeh A, 2012, CURR MED CHEM, V19, P4000
   Godler DE, 2011, J MOL DIAGN, V13, P528, DOI 10.1016/j.jmoldx.2011.05.006
   Godler DE, 2012, CLIN CHEM, V58, P590, DOI 10.1373/clinchem.2011.177626
   Godler DE, 2010, HUM MOL GENET, V19, P1618, DOI 10.1093/hmg/ddq037
   GOLDBERG IJ, 1990, J BIOL CHEM, V265, P4266
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   Harel M, 2004, NAT STRUCT MOL BIOL, V11, P412, DOI 10.1038/nsmb767
   Harr SD, 1996, J NEUROCHEM, V66, P2429
   Hartley SL, 2012, INT J BEHAV DEV, V36, P53, DOI 10.1177/0165025411406857
   HERBERT J, 1986, NEUROLOGY, V36, P900
   Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
   JONAS A, 1984, EXP LUNG RES, V6, P255, DOI 10.3109/01902148409109252
   KAMBOH MI, 1992, GENET EPIDEMIOL, V9, P379
   LADU BN, 1993, CHEM-BIOL INTERACT, V87, P25, DOI 10.1016/0009-2797(93)90022-Q
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Ming X, 2012, J PROTEOME RES, V11, P5856, DOI 10.1021/pr300910n
   Momeni N, 2012, AUTISM RES TREAT, V2012
   Momeni N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.19
   Mulvihill B., 2009, MMWR SURVEILL SUMM, V58, P1
   Napoli E, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-2
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nesvizhskii AI, 2003, ANAL CHEM, V75, P4646, DOI 10.1021/ac0341261
   Ngounou Wetie AG, 2013, J MOL PSYCHIAT, V1, P8, DOI DOI 10.1186/2049-9256-1-8
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Panin LE, 2000, BIOCHEMISTRY-MOSCOW+, V65, P1419, DOI 10.1023/A:1002861008363
   Park JY, 2012, J BIOCHEM, V151, P291, DOI 10.1093/jb/mvr137
   Pasca SP, 2010, J CELL MOL MED, V14, P600, DOI 10.1111/j.1582-4934.2008.00414.x
   PITAS RE, 1987, J BIOL CHEM, V262, P14352
   Qin XF, 2005, CURR DRUG TARGETS, V6, P145
   ROHEIM PS, 1979, P NATL ACAD SCI USA, V76, P4646, DOI 10.1073/pnas.76.9.4646
   Rose S., 2012, AUTISM RES TREAT, V2012, DOI [10.1155/2012/986519, DOI 10.1155/2012/986519]
   Rose S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.61
   SCHAGGER H, 1987, ANAL BIOCHEM, V166, P368, DOI 10.1016/0003-2697(87)90587-2
   Sikora DM, 2006, AM J MED GENET A, V140A, P1511, DOI 10.1002/ajmg.a.31294
   Smile S, 2012, CURR PSYCHIAT REP, V14, P726, DOI 10.1007/s11920-012-0326-3
   Sokolowska I, 2012, PROTEOME SCI, V10, DOI 10.1186/1477-5956-10-47
   Sokolowska I, 2012, ELECTROPHORESIS, V33, P2527, DOI 10.1002/elps.201200182
   Spellman DS, 2008, MOL CELL PROTEOMICS, V7, P1067, DOI 10.1074/mcp.M700387-MCP200
   Stan S, 2003, BBA-MOL CELL BIOL L, V1631, P177, DOI 10.1016/S1388-1981(03)00004-0
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Taurines R, 2010, EUR ARCH PSY CLIN N, V260, P249, DOI 10.1007/s00406-009-0066-5
   Taurines R, 2011, J PSYCHOPHARMACOL, V25, P151, DOI 10.1177/0269881109106931
   Tierney E, 2001, AM J MED GENET, V98, P191, DOI 10.1002/1096-8628(20010115)98:2<191::AID-AJMG1030>3.0.CO;2-M
   Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185
   Vizcaino JA, 2013, NUCLEIC ACIDS RES, V41, pD1063, DOI 10.1093/nar/gks1262
   Wallace KS, 2010, J CHILD PSYCHOL PSYC, V51, P1300, DOI 10.1111/j.1469-7610.2010.02308.x
   Wang R, 2012, NAT BIOTECHNOL, V30, P135, DOI 10.1038/nbt.2112
   Woods Alisa G, 2013, J Mol Psychiatry, V1, P6, DOI 10.1186/2049-9256-1-6
   Woods AG, 2012, J CELL MOL MED, V16, P1184, DOI 10.1111/j.1582-4934.2012.01543.x
   Zhou WD, 2009, J PROTEOME RES, V8, P5523, DOI 10.1021/pr900603n
   Zwaigenbaum L, 2010, CURR OPIN NEUROL, V23, P97, DOI 10.1097/WCO.0b013e3283372430
NR 70
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0173-0835
EI 1522-2683
J9 ELECTROPHORESIS
JI Electrophoresis
PD JUL
PY 2014
VL 35
IS 14
BP 2046
EP 2054
DI 10.1002/elps.201300370
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA AM2EG
UT WOS:000339661300016
ER

PT J
AU Fujiwara, T
   Kawachi, I
AF Fujiwara, Takeo
   Kawachi, Ichiro
TI Are Maternal Social Networks and Perceptions of Trust Associated with
   Suspected Autism Spectrum Disorder in Offspring? A Population-Based
   Study in Japan
SO PLOS ONE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; QUALITY-OF-LIFE; ZINC-DEFICIENCY;
   PARENTAL AGE; CHILDREN; RISK; HEALTH; COPPER; LEVEL
AB Objective: To investigate the associations of maternal social networks and perceptions of trust with the prevalence of suspected autism spectrum disorders in 18-month-old offspring in Japan.
   Methods: Questionnaires included measurements of maternal social networks (number of relatives or friends they could call upon for assistance), maternal perceptions of trust, mutual assistance (i.e. individual measures of "cognitive social capital"), and social participation (i.e. individual measures of "structural social capital") as well as the Modified Checklist for Autism in Toddlers to detect suspected autism spectrum disorder (ASD). These tools were mailed to all families with 18-month-old toddlers in Chiba, a city near Tokyo (N = 6061; response rate: 64%). The association between social capital or social network indicators and suspected ASD were analyzed, adjusted for covariates by logistic regression analysis.
   Results: Low maternal social trust was found to be significantly positively associated with suspected ASD in toddlers compared with high maternal social trust (adjusted odds ratio [OR]: 1.82, 95% confidence interval [CI]: 1.38 to 2.40); mutual aid was also significantly positively related (low vs. high: OR, 1.82, 95% CI: 1.38 to 2.40). However, maternal community participation showed U-shape association with suspected ASD of offspring. Maternal social network showed consistent inverse associations with suspected ASD of offspring, regardless of the type of social connection (e. g., relatives, neighbors, or friends living outside of their neighborhood).
   Conclusions: Mothers' cognitive social capital and social networks, but not structural social capital, might be associated with suspected ASD in offspring.
C1 [Fujiwara, Takeo] Natl Res Inst Child Hlth & Dev, Dept Social Med, Setagaya Ku, Tokyo, Japan.
   [Kawachi, Ichiro] Harvard Univ, Sch Publ Hlth, Dept Soc & Behav Sci, Boston, MA 02115 USA.
RP Fujiwara, T (reprint author), Natl Res Inst Child Hlth & Dev, Dept Social Med, Setagaya Ku, Tokyo, Japan.
EM fujiwara-tk@ncchd.go.jp
FU Ministry of Education, Culture, Sports, Science and Technology KAKENHI
   [21119003]
FX This study was supported by grants from a Grant-in-aid for Scientific
   Research on Innovative Areas, Ministry of Education, Culture, Sports,
   Science and Technology KAKENHI (21119003). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Aoyama M, 2013, ENVIRON HEALTH PREV, V18, P57, DOI 10.1007/s12199-012-0303-9
   Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
   Faber S, 2009, BIOMARKERS, V14, P171, DOI 10.1080/13547500902783747
   Fowler JH, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a2338
   Fujiwara T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052018
   Fujiwara T, 2008, AM J PREV MED, V35, P139, DOI 10.1016/j.amepre.2008.04.015
   Fujiwara T, 2012, ACTA MED OKAYAMA, V66, P343
   Fujiwara T, 2008, J EPIDEMIOL COMMUN H, V62, P627, DOI 10.1136/jech.2007.064261
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   GOLUB MS, 1995, J NUTR, V125, pS2263
   Grabrucker Andreas M, 2012, Front Psychiatry, V3, P118, DOI 10.3389/fpsyt.2012.00118
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Honda H, 2009, J CHILD PSYCHOL PSYC, V50, P972, DOI 10.1111/j.1469-7610.2009.02055.x
   Inada N, 2011, RES AUTISM SPECT DIS, V5, P330, DOI 10.1016/j.rasd.2010.04.016
   Karr CJ, 2007, PEDIATR CLIN N AM, V54, P63, DOI 10.1016/j.pcl.2006.11.005
   Kawachi I, 1997, AM J PUBLIC HEALTH, V87, P1491, DOI 10.2105/AJPH.87.9.1491
   Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
   Lampi KM, 2013, J AUTISM DEV DISORD, V43, P2526, DOI 10.1007/s10803-013-1801-3
   Libbey JE, 2005, J NEUROVIROL, V11, P1, DOI 10.1080/13550280590900553
   Lipman EL, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-4
   Ministry of Health Labor and Welfare, 2012, INC DISTR
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489
   Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
   Murayama H, 2012, J EPIDEMIOL, V22, P179, DOI 10.2188/jea.JE20110128
   Pardo Carlos A, 2005, Int Rev Psychiatry, V17, P485, DOI 10.1080/02646830500381930
   Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
   Priya MDL, 2011, BIOL TRACE ELEM RES, V142, P148, DOI 10.1007/s12011-010-8766-2
   Rai D, 2012, J AM ACAD CHILD PSY, V51, P467, DOI 10.1016/j.jaac.2012.02.012
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351
   Sullivan A, 2012, J APPL RES INTELLECT, V25, P484, DOI 10.1111/j.1468-3148.2012.00695.x
   Ueshima K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012135
   Wan MW, 2013, J CHILD PSYCHOL PSYC, V54, P763, DOI 10.1111/jcpp.12032
   Windham GC, 2009, AUTISM RES, V2, P183, DOI 10.1002/aur.84
   Yamada A, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-119
   Yasuda H, 2011, SCI REP-UK, V1, DOI 10.1038/srep00129
NR 39
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 1
PY 2014
VL 9
IS 7
AR e101359
DI 10.1371/journal.pone.0101359
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM1UX
UT WOS:000339635000096
PM 24983630
ER

PT J
AU Cheng, H
   Chang, CC
   Chang, YC
   Lee, WK
   Tzang, RF
AF Cheng, Helen
   Chang, Cheng-Chen
   Chang, Yue-Cune
   Lee, Wen-Kuei
   Tzang, Ruu-Fen
TI A Pilot Study: Association between Minor Physical Anomalies in Childhood
   and Future Mental Problems
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Minor physical anomalies; Psychiatric symptom
ID NORMAL-CHILDREN; BEHAVIOR; SCHIZOPHRENIA; FAMILIES; AUTISM
AB Objective This study aims to investigate association between early recognizable minor physical abnormality (MPA) during childhood is associated with mental health problems in young adults.
   Methods In 1984, 169 preschool children in central Taiwan underwent a detailed physical examination for subtle abnormalities (MPA). Fourteen years later, the Brief Symptom Rating Scale (BSRS) and Chinese Health Questionnaire (CHQ) were used to measure specific psychiatric symptoms.
   Results There is an association between MPA during childhood and adult characterized with interpersonal, sensitivity, anxiety, depression and paranoid mental health symptoms.
   Conclusion The signs of childhood MPA can be easily identified and should be regarded as risk factors when predicting mental disorder. Mental health professionals should consider MPAs as important signs for possible development of emotional problems.
C1 [Cheng, Helen; Chang, Cheng-Chen] Changhua Christian Hosp, Dept Psychiat, Changhua, Taiwan.
   [Chang, Cheng-Chen] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
   [Chang, Yue-Cune] Tamkang Univ, Dept Math, Taipei, Taiwan.
   [Lee, Wen-Kuei] Triserv Gen Hosp, Beitou Branch, Dept Psychiat, Taipei, Taiwan.
   [Tzang, Ruu-Fen] Mackay Mem Hosp, Dept Psychiat, Taipei 104, Taiwan.
   [Tzang, Ruu-Fen] Natl Taipei Univ Nursing & Hlth Sci, Dept Hlth Care Management, Taipei, Taiwan.
RP Tzang, RF (reprint author), Mackay Mem Hosp, Dept Psychiat, 92,Sec 2,Chung Shan N Rd, Taipei 104, Taiwan.
EM rf.tzang@msa.hinet.net
CR Akabaliev VH, 2007, PSYCHIAT RES, V150, P81, DOI 10.1016/j.psychres.2003.02.002
   Arseneault L, 2000, AM J PSYCHIAT, V157, P917, DOI 10.1176/appi.ajp.157.6.917
   CAMPBELL M, 1978, AM J PSYCHIAT, V135, P573
   Cheung C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020246
   CHONG MY, 1989, PSYCHOL MED, V19, P495
   FIRESTONE P, 1983, J AUTISM DEV DISORD, V13, P411, DOI 10.1007/BF01531589
   FIRESTONE P, 1978, J CHILD PSYCHOL PSYC, V19, P155, DOI 10.1111/j.1469-7610.1978.tb00456.x
   FIRESTONE P, 1983, J ABNORM CHILD PSYCH, V11, P207, DOI 10.1007/BF00912086
   Franco JG, 2012, REV NEUROLOGIA, V54, P468
   Hardan AY, 2006, J AUTISM DEV DISORD, V36, P607, DOI 10.1007/s10803-006-0103-4
   John JP, 2008, COMPR PSYCHIAT, V49, P78, DOI 10.1016/j.comppsych.2007.07.005
   KANDEL E, 1989, ACTA PSYCHIAT SCAND, V79, P103, DOI 10.1111/j.1600-0447.1989.tb09241.x
   Lee M B, 1990, J Formos Med Assoc, V89, P1081
   PAULHUS DL, 1986, J PERS SOC PSYCHOL, V50, P1235, DOI 10.1037//0022-3514.50.6.1235
   Pine DS, 1997, J AM ACAD CHILD PSY, V36, P395, DOI 10.1097/00004583-199703000-00019
   Raine A, 2002, J CHILD PSYCHOL PSYC, V43, P417, DOI 10.1111/1469-7610.00034
   Rodier PM, 1997, TERATOLOGY, V55, P319, DOI 10.1002/(SICI)1096-9926(199705)55:5<319::AID-TERA4>3.0.CO;2-U
   ROSENBER.JB, 1973, DEV MED CHILD NEUROL, V15, P131
   STEG JP, 1975, J AUTISM CHILD SCHIZ, V5, P299, DOI 10.1007/BF01540677
   Trixler M, 2001, SCHIZOPHR RES, V52, P195, DOI 10.1016/S0920-9964(00)00182-1
   Ulovec Z, 2002, COLLEGIUM ANTROPOL, V26, P119
   WALDROP MF, 1968, CHILD DEV, V39, P391, DOI 10.1111/j.1467-8624.1968.tb04433.x
NR 22
TC 0
Z9 0
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUL
PY 2014
VL 11
IS 3
BP 228
EP 231
DI 10.4306/pi.2014.11.3.228
PG 4
WC Psychiatry
SC Psychiatry
GA AM3SV
UT WOS:000339774000003
PM 25110493
ER

PT J
AU Say, GN
   Sahin, B
   Aslan, K
   Akbas, S
   Incesu, L
   Ceyhan, M
AF Say, Gokce Nur
   Sahin, Bunyamin
   Aslan, Kerim
   Akbas, Seher
   Incesu, Lutfi
   Ceyhan, Meltem
TI Increased Laterality of the Thalamus in Children and Adolescents with
   Asperger's Disorder: An MRI and Proton Spectroscopy Study
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Asperger; Autism; Thalamus; Laterality; Language; Children
ID AUTISM SPECTRUM DISORDERS; BRAIN SIZE; VOLUME; IMAGES
AB Objective Thalamic abnormalities have been reported in people with pervasive developmental disorders (PDD) including Asperger's Disorder (ASP). The aim of the present study was to compare the volume and volume fraction of the thalamus and the metabolite concentrations in children and adolescents with ASP using the magnetic resonance imaging and proton magnetic resonance spectroscopy. Additionally, the relationships between thalamic abnormalities and clinical features were examined.
   Methods Volume and volume fractional and metabolic measurements of bilateral thalamus were collected from 15 boys with ASP with a total IQ over 70 (age range 7-18 years, mean age 11.6 +/- 3.79 years), and 15 healthy controls matching age, sex and IQ. The thalamic volumes, hemisphere volumes and total brain volumes (TBV) were estimated using the stereological methods on magnetic resonance images. Chemical metabolites of thalamus were evaluated by H-1 spectroscopy.
   Results No differences in thalamic volumes, volume fractions and metabolites were observed between the groups. There were significant correlation between thalamic volume and total brain volume in both groups. The ASP group showed a significant left-minus-right thalamus difference as well as a significantly greater laterality index. In addition, a significant correlation between the laterality index and Autism Behavior Checklist language scores was observed.
   Conclusion Findings from this investigation point to a significant increase in laterality of the thalamus and a relationship with language problems in individuals with ASP. Our findings suggest that thalamic abnormalities may be related to mild language problems observed in ASP.
C1 [Say, Gokce Nur; Akbas, Seher] Ondokuz Mayis Univ, Fac Med, Dept Child & Adolescent Psychiat, TR-55139 Kurupelit, Samsun, Turkey.
   [Sahin, Bunyamin] Ondokuz Mayis Univ, Fac Med, Dept Anat, TR-55139 Kurupelit, Samsun, Turkey.
   [Aslan, Kerim; Incesu, Lutfi; Ceyhan, Meltem] Ondokuz Mayis Univ, Fac Med, Dept Radiol, TR-55139 Kurupelit, Samsun, Turkey.
RP Say, GN (reprint author), Ondokuz Mayis Univ, Tip Fak Hastanesi, Cocuk & Ergen Psikiyatrisi Anabilim Dali, TR-55139 Kurupelit, Samsun, Turkey.
EM gokcenurtasdemir@yahoo.com.tr
RI Sahin, Bunyamin/L-5414-2014
OI Sahin, Bunyamin/0000-0001-8538-8443
FU Ondokuz Mayis University Scientific Research
FX This study was supported by Ondokuz Mayis University Scientific Research
   Funding.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Aoki Y, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2011.65
   Friedman SD, 2003, NEUROLOGY, V60, P100
   Gillberg C, 2002, GUIDE ASPERGER SYNDR
   Gokler B, 2004, COCUK GENCLIK RUH SA, V11, P109
   Hardan AY, 2008, J AUTISM DEV DISORD, V38, P390, DOI 10.1007/s10803-007-0385-1
   Hardan AY, 2008, PSYCHIAT RES-NEUROIM, V163, P97, DOI 10.1016/j.pscychresns.2007.12.002
   Hardan AY, 2006, PSYCHIAT RES-NEUROIM, V147, P145, DOI 10.1016/j.pscychresns.2005.12.009
   Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252
   Hebb AO, 2013, BRAIN LANG, V126, P99, DOI 10.1016/j.bandl.2012.06.010
   Katz LC, 1996, SCIENCE, V274, P1133, DOI 10.1126/science.274.5290.1133
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Levitt JG, 2003, BIOL PSYCHIAT, V54, P1355, DOI 10.1016/S0006-3223(03)00688-7
   Muller RA, 1998, NEUROSCI LETT, V245, P1, DOI 10.1016/S0304-3940(98)00151-7
   Perich-Alsina J, 2002, Rev Neurol, V34 Suppl 1, pS68
   Sahin B, 2012, NEUROQUANTOLOGY, V10, P87
   Sahin B, 2006, EUR J RADIOL, V57, P96, DOI 10.1016/j.ejrad.2005.07.006
   Tamura R, 2010, PSYCHIAT RES-NEUROIM, V184, P186, DOI 10.1016/j.pscychresns.2010.07.001
   Tsatsanis KD, 2003, BIOL PSYCHIAT, V53, P121, DOI 10.1016/S0006-3223(02)01530-5
   Yilmaz-Irmak T, 2007, TURK J CHILD ADOLESC, V14, P13
NR 20
TC 0
Z9 0
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUL
PY 2014
VL 11
IS 3
BP 237
EP 242
DI 10.4306/pi.2014.11.3.237
PG 6
WC Psychiatry
SC Psychiatry
GA AM3SV
UT WOS:000339774000005
PM 25110495
ER

PT J
AU Yoo, HJ
   Yang, SY
   Cho, IH
   Park, M
   Kim, SA
AF Yoo, Hee Jeong
   Yang, So Young
   Cho, In Hee
   Park, Mira
   Kim, Soon Ae
TI Polymorphisms of BDNF Gene and Autism Spectrum Disorders: Family Based
   Association Study with Korean Trios
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Autism spectrum disorders; Brain derived neurotropic factor;
   Quantitative transmission disequilibrium test; Family based association
   study
ID NEUROTROPHIC FACTOR; MENTAL-RETARDATION; SYNAPSES; SERUM
AB Objective Autism spectrum disorders (ASPS) are a group of early childhood-onset neurodevelopmental disorders characterized by deficits in social interaction and language skills, and repetitive behaviors. Brain-derived neurotrophic factor (BDNF) plays a critical role in the differentiation of normal neuronal cells during embryonic and postnatal neuronal development through its neurotrophic effects.
   Methods In this study, we performed a family-based association test (FBAT) between single nucleotide polymorphisms (SNPs; rs6265, rs11030101, rs7103411, and rs7103873) or haplotypes in the BDNF gene and affection status Or several quantitative traits characterized by ADI-R with 151 Korean trios, including a child diagnosed as ASDs.
   Results While no significant association was found between SNPs or haplotypes and the ASDs disease status, a quantitative transmission disequilibrium test (QTDT) by using quantitative traits identified associations of the SNPs (rs6265 and rs11030101) with a domain score for "Restricted, Repetitive and Stereotyped patterns of behavior" (C domain), especially at the subdomain scores for "encompassing preoccupation or circumscribed pattern of interest" (C1) (rs6265A allele, dominant model, p-value=0.019; rs11030101 A allele, additive model, p-value=0.015) and "preoccupations with part of objects or non-functional elements of material" (C4) (rs11030101 A allele, additive Model, p-value=0.015) within the ADI-R diagnostic algorithm. In addition, significant associations were also identified between the haplotypes and these quantitative traits (C1, p-value=0.016; C4, p-Value=0.012).
   Conclusion We conclude that BDNF gene polymorphisms have a possible role in the pathogenesis of ASDs.
C1 [Yoo, Hee Jeong] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, South Korea.
   [Yang, So Young] Chungnam Natl Univ, Coll Pharm, Dept Pharmacol, Taejon, South Korea.
   [Cho, In Hee] Gachon Univ Med & Sci, Dept Psychiat, Inchon, South Korea.
   [Park, Mira] Eulji Univ, Sch Med, Dept Prevent Med, Taejon 301768, South Korea.
   [Kim, Soon Ae] Eulji Univ, Sch Med, Dept Pharmacol, Taejon 301768, South Korea.
RP Kim, SA (reprint author), Eulji Univ, Sch Med, Dept Pharmacol, 77 Gyeryong Ro, Taejon 301768, South Korea.
EM sakim@eulji.ac.kr
FU National Research Foundation of Korea (NRF) - Korea government (MEST)
   [2010-0007583]; Korea Healthcare Technology R&D Project from the
   Ministry of Health and Welfare, Republic of Korea [A120029]; Basic
   Science Research Program through the National Research Foundation of
   Korea (NRF) - Ministry of Education, Science and Technology
   [20100012133]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MEST) (2010-0007583). This
   work was also supported by a research grant from Korea Healthcare
   Technology R&D Project (A120029) from the Ministry of Health and
   Welfare, Republic of Korea. Mira Park was was supported by the Basic
   Science Research Program through the National Research Foundation of
   Korea (NRF) funded by the Ministry of Education, Science and Technology
   (20100012133).
CR BAILEY A, 1995, PSYCHOL MED, V25, P63
   Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
   Blum R, 2002, NATURE, V419, P687, DOI 10.1038/nature01085
   Buxbaum Joseph D, 2009, Dialogues Clin Neurosci, V11, P35
   Cardenas-Aguayo Mdel C., 2013, PLOS ONE, V8
   Cheng L, 2009, J BIOMED NANOTECHNOL, V5, P542, DOI 10.1166/jbn.2009.1058
   Durand GM, 1996, NATURE, V381, P71, DOI 10.1038/381071a0
   Fiala JC, 2002, BRAIN RES REV, V39, P29, DOI 10.1016/S0165-0173(02)00158-3
   Gadow KD, 2009, J AUTISM DEV DISORD, V39, P1542, DOI 10.1007/s10803-009-0794-4
   Gomes RA, 2006, J NEUROSCI, V26, P11487, DOI 10.1523/JNEUROSCI.2364-06.2006
   Han JC, 2013, CORTEX, V49, P2700, DOI 10.1016/j.cortex.2013.02.009
   Horvath S, 2001, GENET EPIDEMIOL, V21, pS403
   Huang EJ, 2001, ANNU REV NEUROSCI, V24, P677, DOI 10.1146/annurev.neuro.24.1.677
   Ippolito DL, 2002, J BIOL CHEM, V277, P32692, DOI 10.1074/jbc.M204407200
   Itami C, 2003, P NATL ACAD SCI USA, V100, P13069, DOI 10.1073/pnas.2131948100
   Katoh-Semba R, 2007, INT J DEV NEUROSCI, V25, P367, DOI 10.1016/j.ijdevneu.2007.07.002
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Miyazaki K, 2004, BRAIN DEV-JPN, V26, P292, DOI 10.1016/S0387-7604(03)00168-2
   Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
   Nishimura K, 2007, BIOCHEM BIOPH RES CO, V356, P200, DOI 10.1016/j.bbrc.2007.02.135
   O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3
   Raznahan A, 2009, J NEURODEV DISORD, V1, P215, DOI 10.1007/s11689-009-9012-0
   Scattoni ML, 2013, BEHAV BRAIN RES, V251, P35, DOI 10.1016/j.bbr.2012.12.028
   Scherer SW, 2011, HUM GENET, V130, P123, DOI 10.1007/s00439-011-1037-2
   Shinawi M, 2011, AM J MED GENET A, V155A, P1272, DOI 10.1002/ajmg.a.33878
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tsai SJ, 2005, MED HYPOTHESES, V65, P79, DOI 10.1016/j.mehy.2005.01.034
   TUSZYNSKI MH, 1994, ANN NEUROL, V35, pS9, DOI 10.1002/ana.410350705
   Tyler WJ, 2006, J PHYSIOL-LONDON, V574, P787, DOI 10.1113/jphysiol.2006.111310
   Yang SY, 2012, NEUROSCI RES, V73, P333, DOI 10.1016/j.neures.2012.05.012
   Yoo HJ, 2007, KOREAN VERSION AUTIS
   Yoshii A, 2010, DEV NEUROBIOL, V70, P304, DOI 10.1002/dneu.20765
NR 32
TC 0
Z9 0
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUL
PY 2014
VL 11
IS 3
BP 319
EP 324
DI 10.4306/pi.2014.11.3.319
PG 6
WC Psychiatry
SC Psychiatry
GA AM3SV
UT WOS:000339774000016
PM 25110506
ER

PT J
AU Perkins, MR
AF Perkins, Michael R.
TI Linguistic recycling in typical and atypical interaction
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE Alignment; interaction; linguistic recycling; memory; priming
ID LANGUAGE; AUTISM; COMMUNICATION; CONVERSATION; PSYCHOLOGY; REPETITION;
   ECHOLALIA; ALIGNMENT
AB I present evidence that linguistic "recycling" - i.e., the redeployment of linguistic material from prior utterances during conversation - is a striking and prevalent feature not only of interaction between typical speakers, but also, and notably, of interaction involving the communication impaired. In the latter case, recycling may sometimes be used as a compensatory communicative resource when linguistic ability is compromised. Despite its prevalence, however, recycling has largely been ignored by clinical linguists. In addition to providing illustrations of linguistic recycling across a range of communication disorders, I also examine how it is subserved by phenomena such as priming, short-term memory and alignment. I subsequently argue for a shift in perspective that puts recycling at the heart of our perception of how typical and atypical interaction works, and suggest a number of potential benefits for clinical linguistics, ranging from the way we understand and analyse communication disorders to how we assess and treat them.
C1 Univ Sheffield, Dept Human Commun Sci, Sheffield S10 2TS, S Yorkshire, England.
RP Perkins, MR (reprint author), Univ Sheffield, Dept Human Commun Sci, 362 Mushroom Lane, Sheffield S10 2TS, S Yorkshire, England.
EM m.perkins@sheffield.ac.uk
CR Barth-Weingarten D, 2011, RES LANG SOC INTERAC, V44, P157, DOI 10.1080/08351813.2011.567099
   BAYLES KA, 1985, BRAIN LANG, V25, P102, DOI 10.1016/0093-934X(85)90123-3
   Beeke S, 2003, CLIN LINGUIST PHONET, V17, P109, DOI 10.1080/0269920031000061786
   BOCK JK, 1986, COGNITIVE PSYCHOL, V18, P355, DOI 10.1016/0010-0285(86)90004-6
   Brown G., 1983, DISCOURSE ANAL
   Dobbinson S, 2003, CLIN LINGUIST PHONET, V17, P299, DOI 10.1080/0269920031000080046
   Elliott C. D., 1977, BRIT ABILITY SCALES
   Gathercole S. E., 1993, WORKING MEMORY LANGU
   Giles H., 1991, CONTEXTS ACCOMMODATI
   Hartsuiker RJ, 1998, BRAIN LANG, V62, P221, DOI 10.1006/brln.1997.1905
   Hesketh A., 2013, PLOS ONE, V8, P1
   Howard SJ, 2012, CLIN LINGUIST PHONET, V26, P882, DOI 10.3109/02699206.2012.714048
   IBAYASHI K, 1992, J NEUROLINGUIST, V7, P241, DOI 10.1016/0911-6044(92)90005-H
   Levinson S, 2006, DISCOURSE STUD, V8, P85, DOI 10.1177/1461445606059557
   Lieven E., 2008, HDB COGNITIVE LINGUI, P168
   Linell P, 2009, ADV CULT PSYCHOL CON, pXXI
   LOCAL J, 1995, CLIN LINGUIST PHONET, V9, P155, DOI 10.3109/02699209508985330
   Marlaire C. L., 1992, QUALITATIVE SOCIOLOG, V15, P177, DOI DOI 10.1007/BF00989493
   Muskett T, 2013, THEOR PSYCHOL, V23, P205, DOI 10.1177/0959354312472097
   Muskett T, 2012, CHILD LANG TEACH THE, V28, P87, DOI 10.1177/0265659011428966
   Oelschlaeger ML, 2000, J COMMUN DISORD, V33, P205, DOI 10.1016/S0021-9924(00)00019-8
   PERKINS M, 1994, CLIN LINGUIST PHONET, V8, P321, DOI 10.3109/02699209408985315
   Perkins M. R., 1995, CASE STUDIES CLIN LI, P293
   Perkins Michael R., 2007, PRAGMATIC IMPAIRMENT
   Perkins MR, 2006, J AUTISM DEV DISORD, V36, P795, DOI 10.1007/s10803-006-0120-3
   Pickering MJ, 2004, BEHAV BRAIN SCI, V27, P169
   Pickering MJ, 2008, PSYCHOL BULL, V134, P427, DOI 10.1037/0033-2909.134.3.427
   Riches NG, 2012, INT J LANG COMM DIS, V47, P499, DOI 10.1111/j.1460-6984.2012.00158.x
   Schegloff EA, 2007, SEQUENCE ORGANIZATION IN INTERACTION: A PRIMER IN CONVERSATION ANALYSIS I, P1, DOI 10.2277/ 0521532795
   Schegloff E.A., 1987, TALK SOCIAL ORG
   Sterponi L, 2014, J CHILD LANG, V41, P275, DOI 10.1017/S0305000912000682
   Stivers T, 2008, RES LANG SOC INTERAC, V41, P31, DOI 10.1080/08351810701691123
   Tarling K, 2006, CLIN LINGUIST PHONET, V20, P583, DOI 10.1080/02699200500266547
   Wilkinson R., 2011, APPL CONVERSATION AN, P32
   Wilson B. A., 1985, RIVERMEAD BEHAV MEMO
   Wray A, 2000, LANG COMMUN, V20, P1, DOI 10.1016/S0271-5309(99)00015-4
NR 36
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9206
EI 1464-5076
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD JUL-AUG
PY 2014
VL 28
IS 7-8
BP 590
EP 601
DI 10.3109/02699206.2014.926995
PG 12
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AL9UJ
UT WOS:000339487100011
PM 25000380
ER

PT J
AU Weiss, AL
   Rohland, P
AF Weiss, Amy L.
   Rohland, Pamela
TI "Measuring up" to ethical standards in service delivery to college
   students on the Autism Spectrum: A practical application of Powell's
   model for ethical practices in clinical phonetics and linguistics
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE Autism; ethical standards; intervention
AB This paper examined an interdisciplinary college-based support programme, the Communication Coaching Program (CCP), designed for students diagnosed on the autism spectrum in light of six ethical constructs described by Powell. Collecting data to monitor the successes and ongoing needs of individual participants in the programme is of vital importance, of course, but only addresses a portion of the efficacy question. In addition, the authors, who co-direct the programme and represent different professional expertise and perspectives, recognize the importance of determining whether their evolving intervention model has also been successful in meeting the ethical standards of their respective professions. Careful review of the 4 years of the CCP's operation in terms of ethical constructs has yielded evidence that the CCP, although based on sound principles of theory and scholarship, should be further individualized to meet the particular needs of participants diagnosed with deficits in social communication and executive functioning skills.
C1 [Weiss, Amy L.] Univ Rhode Isl, Dept Commun Disorders, Kingston, RI 02881 USA.
   [Rohland, Pamela] Univ Rhode Isl, Off Student Life, Disabil Serv Students, Kingston, RI 02881 USA.
RP Weiss, AL (reprint author), Univ Rhode Isl, Dept Commun Disorders, Kingston, RI 02881 USA.
EM weissa@mail.uri.edu
CR AHEAD-Association of Higher Education and Disability, 2004, PROF STAND
   AHEAD-Association of Higher Education and Disability, 2004, COD ETH
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   American Speech-Language-Hearing Association, 2010, COD ETH ETH
   American Speech-Language-Hearing Association, 2006, ROL RESP SPEECH LANG
   Brown J., 2009, STUDENTS ASPERGER SY
   Council for Clinical Certification in Audiology and Speech-Language Pathology of the American Speech-Language-Hearing Association, 2012, 2014 STAND CERT CLIN
   Hewitt LE, 2011, TOP LANG DISORD, V31, P273, DOI 10.1097/TLD.0b013e318227fd19
   Larson V., 2005, ASPERGER SYNDROME ST
   Pope R. L., 2004, MULTICULTURAL COMPET
   Powell TW, 2007, CLIN LINGUIST PHONET, V21, P851, DOI 10.1080/02699200701576777
   Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
NR 14
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9206
EI 1464-5076
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD JUL-AUG
PY 2014
VL 28
IS 7-8
BP 627
EP 638
DI 10.3109/02699206.2014.927002
PG 12
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA AL9UJ
UT WOS:000339487100014
PM 25000383
ER

PT J
AU Sahun, I
   Marechal, D
   Pereira, PL
   Nalesso, V
   Gruart, A
   Garcia, JMD
   Antonarakis, SE
   Dierssen, M
   Herault, Y
AF Sahun, Ignasi
   Marechal, Damien
   Pereira, Patricia Lopes
   Nalesso, Valerie
   Gruart, Agnes
   Delgado Garcia, Jose Maria
   Antonarakis, Stylianos E.
   Dierssen, Mara
   Herault, Yann
TI Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy
   of a Genomic Region Implicated in Down Syndrome
SO GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; COPY-NUMBER VARIATION; LONG-TERM DEPRESSION;
   RARE DE-NOVO; FUNCTIONAL IMPACT; MICE; GENE; BEHAVIOR; DELPHILIN;
   REVEALS
AB Down syndrome (DS) is due to increased copy number of human chromosome 21. The contribution of different genetic regions has been tested using mouse models. As shown previously, the Abcg1-U2af1 genetic region contributes to cognitive defects in working and short-term recognition memory in Down syndrome mouse models. Here we analyzed the impact of monosomy of the same genetic interval, using a new mouse model, named Ms2Yah. We used several cognitive paradigms and did not detect defects in the object recognition or the Morris water maze tests. However, surprisingly, Ms2Yah mice displayed increased associative memory in a pure contextual fear-conditioning test and decreased social novelty interaction along with a larger long-term potentiation recorded in the CA1 area following stimulation of Schaffer collaterals. Whole-genome expression studies carried out on hippocampus showed that the transcription of only a small number of genes is affected, mainly from the genetic interval (Cbs, Rsph1, Wdr4), with a few additional ones, including the postsynaptic Gabrr2, Gabbr1, Grid2p, Park2, and Dlg1 and the components of the Ubiquitin-mediated proteolysis (Anapc1, Rnf7, Huwe1, Park2). The Abcgl-U2af1 region is undeniably encompassing dosage-sensitive genes or elements whose change in copy number directly affects learning and memory, synaptic function, and autistic related behavior.
C1 [Sahun, Ignasi; Dierssen, Mara] Univ Pompeu Fabra, Ctr Genom Regulat, Syst Biol Programme, E-08003 Barcelona, Spain.
   [Sahun, Ignasi; Dierssen, Mara] Ctr Invest Biomed Red Enfermedades Raras, E-08003 Barcelona, Spain.
   [Sahun, Ignasi; Marechal, Damien; Pereira, Patricia Lopes; Nalesso, Valerie; Herault, Yann] Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France.
   [Marechal, Damien; Nalesso, Valerie; Herault, Yann] Ctr Natl Rech Sci, UMR7104, F-67404 Illkirch Graffenstaden, France.
   [Marechal, Damien; Nalesso, Valerie; Herault, Yann] Inst Natl Sante & Rech Med, U964, Illkirch Graffenstaden, France.
   [Marechal, Damien; Nalesso, Valerie; Herault, Yann] Univ Strasbourg, F-67400 Illkirch Graffenstaden, France.
   [Gruart, Agnes; Delgado Garcia, Jose Maria] Univ Pablo Olavide, Div Neurociencias, Seville 41013, Spain.
   [Antonarakis, Stylianos E.] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland.
   [Herault, Yann] Groupement lnteret Econ Ctr Europeen Rech Biol Mo, PHENOMIN, Inst Clin Souris, F-67404 Illkirch Graffenstaden, France.
RP Herault, Y (reprint author), Ctr Natl Rech Sci, Inst Genet & Biol Mol & Cellulaire, 1 Rue Laurent Fries,BP 10142,Parc Innovat, F-67404 Illkirch Graffenstaden, France.
EM herault@igbmc.fr
RI Antonarakis, Stylianos/N-8866-2014
OI Antonarakis, Stylianos/0000-0001-8907-5823
FU French CNRS; French Institut National de la Sante et de la Recherche
   Medicale; University of Strasbourg; "Centre Europeen de Recherche en
   Biomedecine"; "Fondation Jerome Lejeune"; Koplowitz Foundation; Fragile
   X Research Foundation (FRAXA); Association Francaise contre les
   Myopathies (AFM) Foundation; Spanish Ministry of Economy [SAF2010-16427,
   SAF2007-31093-E, FIS-PI 082038]; Marato TV3; European Commission
   (AnEUploidy project) [LSHG-CT-2006-037627]; DURSI [Grups consolidats 09
   2009SGR1313]
FX We thank members of the research group, of the Institut de Genetique de
   Biologie Moleculaire et Cellulaire (IGBM), of the Institut Clinique de
   la Souris (ICS), and of the AnEUploidy consortium for their helpful
   comments (www.aneuploidy.org). We are grateful to the animal caretakers
   of the Centre National de la Recherche Scientifique (CNRS) UPS44 TAAM
   unit and of the ICS. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. This project was supported by the French CNRS; the French
   Institut National de la Sante et de la Recherche Medicale; the
   University of Strasbourg and the "Centre Europeen de Recherche en
   Biomedecine"; the "Fondation Jerome Lejeune"; Koplowitz, Fragile X
   Research Foundation (FRAXA), and Association Francaise contre les
   Myopathies (AFM) Foundations; the Spanish Ministry of Economy
   (SAF2010-16427, SAF2007-31093-E, and FIS-PI 082038); Marato TV3; and the
   European Commission (AnEUploidy project LSHG-CT-2006-037627 to Y.H. and
   M.D.) The laboratory of M.D. is supported by DURSI (Grups consolidats 09
   2009SGR1313).
CR Arque G, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002575
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Ben-Shachar D, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003676
   Berdeaux R, 2007, NAT MED, V13, P597, DOI 10.1038/nm1573
   Besson V, 2007, HUM MOL GENET, V16, P2040, DOI 10.1093/hmg/ddm152
   Blake JA, 2014, NUCLEIC ACIDS RES, V42, pD810, DOI 10.1093/nar/gkt1225
   Chen XL, 2004, J BIOL CHEM, V279, P52082, DOI 10.1074/jbc.C400481200
   de Bartolomeis A, 2004, INT REV NEUROBIOL, V59, P221
   Duchon A, 2011, BEHAV BRAIN RES, V217, P271, DOI 10.1016/j.bbr.2010.10.023
   Fan Q, 2014, MOL VIS, V20, P117
   Feenstra I, 2006, EUR J MED GENET, V49, P279, DOI 10.1016/j.ejmg.2005.10.131
   FERRANTE E, 1983, HELV PAEDIATR ACTA, V38, P73
   Goldberg MS, 2003, J BIOL CHEM, V278, P43628, DOI 10.1074/jbc.M308947200
   Green EK, 2010, AM J MED GENET B, V153B, P1347, DOI 10.1002/ajmg.b.31108
   Gruart A, 2006, J NEUROSCI, V26, P1077, DOI 10.1523/JNEUROSCI.2834-05.2006
   Gureviciene I, 2004, NEUROBIOL DIS, V15, P188, DOI 10.1016/j.nbd.2003.11.011
   Hannachi H, 2011, CYTOGENET GENOME RES, V135, P102, DOI 10.1159/000330880
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Irizarry RA, 2003, BIOSTATISTICS, V4, P249, DOI 10.1093/biostatistics/4.2.249
   Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
   KASHIWABUCHI N, 1995, CELL, V81, P245, DOI 10.1016/0092-8674(95)90334-8
   Kimura H, 2002, MOL NEUROBIOL, V26, P13, DOI 10.1385/MN:26:1:013
   Korbel JO, 2009, P NATL ACAD SCI USA, V106, P12031, DOI 10.1073/pnas.0813248106
   Kroker KS, 2012, NEUROPHARMACOLOGY, V62, P1964, DOI 10.1016/j.neuropharm.2011.12.021
   Letourneau A, 2014, NATURE, V508, P345, DOI 10.1038/nature13200
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lindstrand A, 2010, CLIN GENET, V77, P145, DOI 10.1111/j.1399-0004.2009.01289.x
   Luo R, 2012, AM J HUM GENET, V91, P38, DOI 10.1016/j.ajhg.2012.05.011
   Lyle R, 2009, EUR J HUM GENET, V17, P454, DOI 10.1038/ejhg.2008.214
   Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Matsuda K, 2006, J BIOL CHEM, V281, P25577, DOI 10.1074/jbc.M602044200
   MCGINNISS MJ, 1992, AM J HUM GENET, V50, P15
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Melis D, 2011, AM J MED GENET A, V155A, P1697, DOI 10.1002/ajmg.a.33976
   Miyagi Y, 2002, J NEUROSCI, V22, P803
   Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
   Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Nithianantharajah J, 2013, NAT NEUROSCI, V16, P16, DOI 10.1038/nn.3276
   Paxinos G, 2001, MOUSE BRAIN STEREOTA
   Pereira PL, 2009, HUM MOL GENET, V18, P4756, DOI 10.1093/hmg/ddp438
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Quintero-Rivera F, 2010, AM J MED GENET A, V152A, P2459, DOI 10.1002/ajmg.a.33573
   Raveau M, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002724
   REEVES RH, 1995, NAT GENET, V11, P177, DOI 10.1038/ng1095-177
   Roberson EDO, 2011, EUR J HUM GENET, V19, P235, DOI 10.1038/ejhg.2010.150
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Shi YH, 2008, CRIT REV ONCOL HEMAT, V65, P43, DOI 10.1016/j.critrevonc.2007.06.004
   Sussan TE, 2008, NATURE, V451, P73, DOI 10.1038/nature06446
   Takemori H, 2007, FEBS J, V274, P3202, DOI 10.1111/j.1742-4658.2007.05889.x
   Takeuchi T, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002297
   Umlauf D, 2008, BIOL CHEM, V389, P323, DOI 10.1515/BC.2008.047
   Vandesompele J, 2002, GENOME BIOL, V3, DOI 10.1186/gb-2002-3-7-research0034
   Varjosalo M, 2013, CELL REP, V3, P1306, DOI 10.1016/j.celrep.2013.03.027
   Wegner M, 2005, TRENDS NEUROSCI, V28, P583, DOI 10.1016/j.tins.2005.08.008
   Yu T, 2010, HUM MOL GENET, V19, P2780, DOI 10.1093/hmg/ddq179
   Yu T, 2010, MAMM GENOME, V21, P258, DOI 10.1007/s00335-010-9262-x
NR 58
TC 1
Z9 1
PU GENETICS SOCIETY AMERICA
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 0016-6731
EI 1943-2631
J9 GENETICS
JI Genetics
PD JUL
PY 2014
VL 197
IS 3
BP 899
EP 912
DI 10.1534/genetics.114.165241
PG 14
WC Genetics & Heredity
SC Genetics & Heredity
GA AL8MA
UT WOS:000339391900009
PM 24752061
ER

PT J
AU Kato, F
   Iwanaga, R
   Chono, M
   Fujihara, S
   Tokunaga, A
   Murata, J
   Tanaka, K
   Nakane, H
   Tanaka, G
AF Kato, Fumi
   Iwanaga, Ryoichiro
   Chono, Mami
   Fujihara, Saori
   Tokunaga, Akiko
   Murata, Jun
   Tanaka, Koji
   Nakane, Hideyuki
   Tanaka, Goro
TI Relationship between Sympathetic Skin Responses and Auditory
   Hypersensitivity to Different Auditory Stimuli
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Auditory hypersensitivity; Sympathetic nervous system; Auditory stimuli
ID MENTAL SWEATING RESPONSE; AUTISTIC SPECTRUM; SENSORY PROFILE; CHILDREN;
   ABNORMALITIES; DISORDER; HUMANS
AB [Purpose] Auditory hypersensitivity has been widely reported in patients with autism spectrum disorders. However, the neurological background of auditory hypersensitivity is currently not clear. The present study examined the relationship between sympathetic nervous system responses and auditory hypersensitivity induced by different types of auditory stimuli. [Methods] We exposed 20 healthy young adults to six different types of auditory stimuli. The amounts of palmar sweating resulting from the auditory stimuli were compared between groups with (hypersensitive) and without (non-hypersensitive) auditory hypersensitivity. [Results] Although no group x type of stimulus x first stimulus interaction was observed for the extent of reaction, significant type of stimulus x first stimulus interaction was noted for the extent of reaction. For an 80 dB-6,000 Hz stimulus, the trends for palmar sweating differed between the groups. For the first stimulus, the variance became larger in the hypersensitive group than in the non-hypersensitive group. [Conclusion] Subjects who regularly felt excessive reactions to auditory stimuli tended to have excessive sympathetic responses to repeated loud noises compared with subjects who did not feel excessive reactions. People with auditory hypersensitivity may be classified into several subtypes depending on their reaction patterns to auditory stimuli.
C1 [Kato, Fumi; Iwanaga, Ryoichiro; Tokunaga, Akiko; Murata, Jun; Tanaka, Koji; Nakane, Hideyuki; Tanaka, Goro] Nagasaki Univ, Grad Sch Biomed Sci, Dept Psychiat Rehabil Sci, Nagasaki 8528520, Japan.
   [Chono, Mami] Hirado City Hlth & Welf Ctr Children Disabil, Hirado, Japan.
   [Fujihara, Saori] NPO Peaacas, Gifu, Japan.
RP Kato, F (reprint author), Nagasaki Univ, Grad Sch Biomed Sci, Dept Psychiat Rehabil Sci, 1-7-1 Sakamoto, Nagasaki 8528520, Japan.
EM fumik_de@hotmail.com
CR Ashburner J, 2008, AM J OCCUP THER, V62, P564
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
   Brown C, 2002, ADOLESCENT ADULT SEN
   Brown C, 2001, AM J OCCUP THER, V55, P75
   Chang MC, 2012, AM J OCCUP THER, V66, P567, DOI 10.5014/ajot.2012.004242
   Gomes E, 2004, ARQ NEURO-PSIQUIAT, V62, P797, DOI 10.1590/S0004-282X2004000500011
   Gravel JS, 2006, EAR HEARING, V27, P299, DOI 10.1097/01.aud.0000215979.65645.22
   Hitoglou M, 2010, PEDIATR NEUROL, V42, P309, DOI 10.1016/j.pediatrneurol.2009.10.009
   Homma S, 2001, NEUROSCI LETT, V305, P1, DOI 10.1016/S0304-3940(01)01759-1
   Homma S, 1998, NEUROSCI LETT, V247, P25, DOI 10.1016/S0304-3940(98)00274-2
   Khalfa S, 2004, HEARING RES, V198, P87, DOI 10.1016/j.heares.2004.07.006
   Kientz MA, 1997, AM J OCCUP THER, V51, P530
   Kobayashi M, 2003, AUTON NEUROSCI-BASIC, V104, P58, DOI 10.1016/S1566-0702(02)00264-3
   Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
   Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
   Miller LJ, 1999, AM J MED GENET, V83, P268, DOI 10.1002/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.3.CO;2-B
   Rosenhall U, 1999, J AUTISM DEV DISORD, V29, P349, DOI 10.1023/A:1023022709710
   Tomchek SD, 2007, AM J OCCUP THER, V61, P190
NR 19
TC 0
Z9 0
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD JUL
PY 2014
VL 26
IS 7
BP 1087
EP 1091
PG 5
WC Rehabilitation
SC Rehabilitation
GA AM1RU
UT WOS:000339626700031
PM 25140103
ER

PT J
AU Swettenham, J
   Remington, A
   Murphy, P
   Feuerstein, M
   Grim, K
   Lavie, N
AF Swettenham, John
   Remington, Anna
   Murphy, Patrick
   Feuerstein, Maike
   Grim, Kelly
   Lavie, Nilli
TI Seeing the Unseen: Autism Involves Reduced Susceptibility to
   Inattentional Blindness
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism spectrum disorder; inattentional blindness; attention; perceptual
   load; development
ID SUPERIOR VISUAL-SEARCH; SELECTIVE ATTENTION; PERCEPTUAL LOAD; SPECTRUM
   DISORDER; COGNITIVE CONTROL; CHILDREN; TASK; CORTEX; INDIVIDUALS;
   RESPONSES
AB Objective: Attention research in individuals with autism spectrum disorder (ASD) has produced conflicting results. Some findings demonstrate greater distractibility while others suggest superior focused attention. Applying Lavie's load theory of attention to account for this discrepancy led us to hypothesize increased perceptual capacity in ASD. Preliminary support for our hypothesis has so far been found for adults with ASD with reaction time (RT) and signal detection sensitivity measures. Here we test the novel prediction we derived from this hypothesis that children with ASD should have lower rates of inattentional blindness than controls. Method: Twenty-four children with ASD (mean age = 10 years 10 months) and 39 typically developing children (age and IQ matched) took part in the study. We assessed the effects of perceptual load on the rates of inattentional blindness in each group. Participants performing a line discrimination task in either a high load or low load condition were presented with an unexpected extra stimulus on a critical trial. Performance on the line judgment task and rates of detection and stimulus identification were recorded. Results: Overall rates of detection and identification were higher in the ASD group than in the controls. Moreover, whereas both detection and identification rates were significantly lower in the high (compared with low) load conditions for the controls, these were unaffected by load in the ASD group. Conclusion: Reduced inattentional blindness rates under load in ASD suggests higher perceptual capacity is a core feature, present from childhood and leading to superior performance in various measures of perception and attention.
C1 [Swettenham, John; Murphy, Patrick; Feuerstein, Maike; Grim, Kelly; Lavie, Nilli] UCL, London WC1N 1PF, England.
   [Remington, Anna; Murphy, Patrick; Feuerstein, Maike; Grim, Kelly; Lavie, Nilli] UCL, Inst Cognit Neurosci, London WC1N 1PF, England.
   [Remington, Anna] Univ Oxford, Dept Expt Psychol, Oxford OX1 2JD, England.
RP Swettenham, J (reprint author), UCL, Chandler House,2 Wakefield St, London WC1N 1PF, England.
EM j.swettenham@ucl.ac.uk
FU Department of Developmental Science; Scott Family Junior Research
   Fellowship
FX We thank Dr Eleni Matechou for her advice regarding statistical
   analyses. Preparation of this article was supported by the Department of
   Developmental Science (JS) and the Scott Family Junior Research
   Fellowship (AR). We gratefully acknowledge the efforts of staff and
   pupils at schools in London who participated in the research, the
   National Autistic Society (United Kingdom) and the charity Resources for
   Autism.
CR Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Ashtari M., 2007, ANN M RAD SOC N AM C
   Bahrami B, 2007, CURR BIOL, V17, P509, DOI 10.1016/j.cub.2007.01.070
   Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x
   BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535
   Burack JA, 2009, J AUTISM DEV DISORD, V39, P471, DOI 10.1007/s10803-008-0647-6
   Carmel D, 2011, J EXP PSYCHOL HUMAN, V37, P1350, DOI 10.1037/a0024320
   Cartwright-Finch U, 2007, COGNITION, V102, P321, DOI 10.1016/j.cognition.2006.01.002
   Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y
   CIESIELSKI KT, 1990, ELECTROEN CLIN NEURO, V75, P207, DOI 10.1016/0013-4694(90)90174-I
   Fletcher-Watson S, 2012, BRIT J DEV PSYCHOL, V30, P446, DOI 10.1111/j.2044-835X.2011.02054.x
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Hubl D, 2003, NEUROLOGY, V61, P1232
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
   Jovicich J, 2001, J COGNITIVE NEUROSCI, V13, P1048, DOI 10.1162/089892901753294347
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Keehn B, 2008, J INT NEUROPSYCH SOC, V14, P990, DOI 10.1017/S1355617708081356
   Keita L, 2010, AUTISM RES, V3, P333, DOI 10.1002/aur.164
   Kemner C, 2008, J AUTISM DEV DISORD, V38, P553, DOI 10.1007/s10803-007-0406-0
   Lavie N, 2005, TRENDS COGN SCI, V9, P75, DOI 10.1016/j.tics.2004.12.004
   Lavie N, 2000, ATTENTION PERFORM, P175
   Lavie N, 2010, CURR DIR PSYCHOL SCI, V19, P143, DOI 10.1177/0963721410370295
   Lavie N, 2004, J EXP PSYCHOL GEN, V133, P339, DOI 10.1037/0096-3445.133.3.339
   LAVIE N, 1994, PERCEPT PSYCHOPHYS, V56, P183, DOI 10.3758/BF03213897
   LAVIE N, 1995, J EXP PSYCHOL HUMAN, V21, P451, DOI 10.1037/0096-1523.21.3.451
   Macdonald JSP, 2008, J EXP PSYCHOL HUMAN, V34, P1078, DOI 10.1037/0096-1523.34.5.1078
   Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036
   Mitchell DJ, 2008, CEREB CORTEX, V18, P1788, DOI 10.1093/cercor/bhm205
   Muggleton N, 2008, J NEUROPHYSIOL, V100, P516, DOI 10.1152/jn.01287.2007
   O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219
   Pinsk MA, 2004, J NEUROPHYSIOL, V92, P622, DOI 10.1152/jn.00974.2003
   Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613
   Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
   Raven J., 1998, MANUAL RAVENS PROGR
   Remington A, 2009, PSYCHOL SCI, V20, P1388, DOI 10.1111/j.1467-9280.2009.02454.x
   Remington AM, 2012, J ABNORM PSYCHOL, V121, P544, DOI 10.1037/a0027670
   Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
   Schwartz S, 2005, CEREB CORTEX, V15, P770, DOI 10.1093/cercor/bhh178
   SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Simons DJ, 1997, TRENDS COGN SCI, V1, P261, DOI 10.1016/S1364-6613(97)01080-2
   Smith H, 2009, J CHILD PSYCHOL PSYC, V50, P300, DOI 10.1111/j.1469-7610.2008.01957.x
   Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831
   Wojciulik E, 1999, NEURON, V23, P747, DOI 10.1016/S0896-6273(01)80033-7
   Yi DJ, 2004, NAT NEUROSCI, V7, P992, DOI 10.1038/nn1294
NR 49
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
EI 1931-1559
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD JUL
PY 2014
VL 28
IS 4
BP 563
EP 570
DI 10.1037/neu0000042
PG 8
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA AL8OF
UT WOS:000339398000009
PM 24417193
ER

PT J
AU Crepel, A
   De Wolf, V
   Brison, N
   Ceulemans, B
   Walleghem, D
   Peuteman, G
   Lambrechts, D
   Steyaert, J
   Noens, I
   Devriendt, K
   Peeters, H
AF Crepel, An
   De Wolf, Veerle
   Brison, Nathalie
   Ceulemans, Berten
   Walleghem, Didier
   Peuteman, Gilian
   Lambrechts, Diether
   Steyaert, Jean
   Noens, Ilse
   Devriendt, Koen
   Peeters, Hilde
TI Association of CDH11 With Non-Syndromic ASD
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE cadherin; autism; chromosomal rearrangement; de novo
ID AUTISM SPECTRUM DISORDERS; CRYPTIC GENOMIC IMBALANCES; COPY-NUMBER
   VARIATION; DE-NOVO; CHROMOSOMAL REARRANGEMENTS; STRUCTURAL VARIATION;
   ARRAY CGH; TRANSLOCATIONS; COMMON; CADHERINS
AB We report a sporadic patient with Autism Spectrum Disorder (ASD), mild intellectual disability and attention deficit hyperactivity disorder (ADHD) with a de novo partial deletion of CADHERIN 11 (CDH11). The deletion is associated with one of the breakpoints of a de novo complex chromosomal rearrangement 46, XY,t(3;16;5)(q29;q22;q15)inv4(p14;q21) ins(4;5)(q21;q14.3q15). Cadherins are cell adhesion molecules involved in synaptic plasticity. Since genetic evidence points towards a role for cadherins in ASD, we studied the possible contribution of CDH11 to ASD. A case-control association study for 14 SNP variants in 519 ASD cases and 1,192 controls showed significant overrepresentation of rs7187376C/C genotypes in the patient group [P = 0.0049 (Chi-square = 7.90 1 df) and O.R. 3.88 C.I. = 1.403-10.733]. There was no association for C/T versus T/T [P = 0.6772 (Chi-square = 0.17 1 df)] nor was there association at the allelic level [P = 0.4373 (Chi-square = 0.6 1 df)]. In addition to the association of common variants in CDH11 with ASD, we studied the possible contribution of rare variants by sequencing CDH11 in 247 patients, and found three novel variants in the coding region of CDH1, of which two variants were unlikely to be causal. Targeted CNV screening in these 247 patients did not reveal copy number variation in CDH11. In conclusion, the data provide evidence for the involvement of CDH11 in ASD which is consistent with the association of other cadherins with ASD and neuropsychiatric diseases. (C) 2014 Wiley Periodicals, Inc.
C1 [Crepel, An; De Wolf, Veerle; Brison, Nathalie; Devriendt, Koen; Peeters, Hilde] Katholieke Univ Leuven, Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium.
   [Crepel, An; De Wolf, Veerle; Brison, Nathalie; Steyaert, Jean; Noens, Ilse; Devriendt, Koen; Peeters, Hilde] Leuven Autism Res LAuRes, Leuven, Belgium.
   [Ceulemans, Berten] Univ Antwerp, Antwerp Univ Hosp UZA, Dept Neurol Pediat Neurol, Edegem, Belgium.
   [Walleghem, Didier] Univ Child & Adolescent Psychiat, Antwerp Hosp Network ZNA, Antwerp, Belgium.
   [Peuteman, Gilian; Lambrechts, Diether] VIB, Vesalius Res Ctr, Leuven, Belgium.
   [Peuteman, Gilian; Lambrechts, Diether] Univ Leuven, Dept Oncol, Lab Translat Genet, Leuven, Belgium.
   [Steyaert, Jean] Katholieke Univ Leuven, Dept Child & Adolescent Psychiat, Leuven, Belgium.
   [Steyaert, Jean] Maastricht Univ, Acad Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands.
   [Steyaert, Jean] Maastricht Univ, Res Inst Growth & Dev GROW, Maastricht, Netherlands.
   [Noens, Ilse] Univ Leuven, Parenting & Special Educ Res Unit, Leuven, Belgium.
   [Noens, Ilse] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
RP Peeters, H (reprint author), Univ Leuven, Ctr Human Genet, Herestr 49, B-3000 Leuven, Belgium.
EM hilde.peeters@med.kuleuven.be
RI Steyaert, Jean/B-5326-2015
OI Steyaert, Jean/0000-0003-2512-4694
FU Research Actions KULeuven [GOA/12/015]; Belgian Science Policy Office
   Interuniversity Attraction Poles (BELSPO-IAP) IAP [P7/43-BeMGI];
   Clinical Research Foundation of UZLeuven
FX Grant sponsor: Research Actions KULeuven GOA/12/015; Grant sponsor:
   Belgian Science Policy Office Interuniversity Attraction Poles
   (BELSPO-IAP) IAP; Grant number: P7/43-BeMGI. K.D.; Grant sponsor:
   Clinical Research Foundation of UZLeuven.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Arikkath J, 2008, TRENDS NEUROSCI, V31, P487, DOI 10.1016/j.tins.2008.07.001
   Awadalla P, 2010, AM J HUM GENET, V87, P316, DOI 10.1016/j.ajhg.2010.07.019
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Baptista J, 2008, AM J HUM GENET, V82, P927, DOI 10.1016/j.ajhg.2008.02.012
   Barrell D, 2009, NUCLEIC ACIDS RES, V37, pD396, DOI 10.1093/nar/gkn803
   Bartelt-Kirbach B, 2010, CELL COMMUN ADHES, V17, P75, DOI 10.3109/15419061.2010.549977
   Chen CP, 2013, J CHIN MED ASSOC, V76, P53, DOI 10.1016/j.jcma.2011.10.016
   De Gregori M, 2007, J MED GENET, V44, P750, DOI 10.1136/jmg.2007.052787
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Gusev A, 2009, GENOME RES, V19, P318, DOI 10.1101/gr.081398.108
   Han B, 2008, ANN HUM GENET, V72, P834, DOI 10.1111/j.1469-1809.2008.00469.x
   Hiller B, 2004, CYDAS ONLINE ANAL SI
   Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
   Kidd JM, 2008, NATURE, V453, P56, DOI 10.1038/nature06862
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lupski JR, 2010, NEW ENGL J MED, V362, P1181, DOI 10.1056/NEJMoa0908094
   Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
   Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
   Manabe T, 2000, MOL CELL NEUROSCI, V15, P534, DOI 10.1006/mcne.2000.0849
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Nagase T, 1998, DNA Res, V5, P31, DOI 10.1093/dnares/5.1.31
   Ng PC, 2006, ANNU REV GENOM HUM G, V7, P61, DOI 10.1146/annurev.genom.7.080505.115630
   Obst-Pernberg K, 1999, J NEUROSCI RES, V58, P130, DOI 10.1002/(SICI)1097-4547(19991001)58:1<130::AID-JNR13>3.0.CO;2-8
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Paradis S, 2007, NEURON, V53, P217, DOI 10.1016/j.neuron.2006.12.012
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Reddy Kavita S, 2005, BMC Med Genet, V6, P3, DOI 10.1186/1471-2350-6-3
   Redies C, 2012, BRAIN RES, V1470, P130, DOI 10.1016/j.brainres.2012.06.020
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Schaaf CP, 2011, NEURON, V70, P806, DOI 10.1016/j.neuron.2011.05.025
   Schluth-Bolard C, 2009, EUR J MED GENET, V52, P291, DOI 10.1016/j.ejmg.2009.05.011
   Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
   Sherry ST, 2001, NUCLEIC ACIDS RES, V29, P308, DOI 10.1093/nar/29.1.308
   Sismani C, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-15
   Staden R, 1996, MOL BIOTECHNOL, V5, P233, DOI 10.1007/BF02900361
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   VANROY N, 1994, GENE CHROMOSOME CANC, V10, P103, DOI 10.1002/gcc.2870100205
   Vermeesch JR, 2012, HUM MUTAT, V33, P906, DOI 10.1002/humu.22076
   Vincent JB, 2006, J MED GENET, V43, P429, DOI 10.1136/jmg.2005.039693
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wong KK, 2007, AM J HUM GENET, V80, P91, DOI 10.1086/510560
   Wu C, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-11-r130
NR 46
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUL
PY 2014
VL 165
IS 5
BP 391
EP 398
DI 10.1002/ajmg.b.32243
PG 8
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA AL4IU
UT WOS:000339097200001
PM 24839052
ER

PT J
AU Cozzolino, R
   De Magistris, L
   Saggese, P
   Stocchero, M
   Martignetti, A
   Di Stasio, M
   Malorni, A
   Marotta, R
   Boscaino, F
   Malorni, L
AF Cozzolino, Rosaria
   De Magistris, Laura
   Saggese, Paola
   Stocchero, Matteo
   Martignetti, Antonella
   Di Stasio, Michele
   Malorni, Antonio
   Marotta, Rosa
   Boscaino, Floriana
   Malorni, Livia
TI Use of solid-phase microextraction coupled to gas chromatography-mass
   spectrometry for determination of urinary volatile organic compounds in
   autistic children compared with healthy controls
SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY
LA English
DT Article
DE Autism; Urine samples; Solid-phase microextraction; Volatile organic
   compounds; Orthogonal projections to latent structures discriminant
   analysis
ID SPECTRUM DISORDERS; CANCER BIOMARKERS; OXIDATIVE STRESS; METABOLOMICS;
   METABONOMICS; DIAGNOSIS; TRIMETHYLAMINE; IDENTIFICATION; CHEMOMETRICS;
   SEROTONIN
AB Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders which have a severe life-long effect on behavior and social functioning, and which are associated with metabolic abnormalities. Their diagnosis is on the basis of behavioral and developmental signs usually detected before three years of age, and there is no reliable biological marker. The objective of this study was to establish the volatile urinary metabolomic profiles of 24 autistic children and 21 healthy children (control group) to investigate volatile organic compounds (VOCs) as potential biomarkers for ASDs. Solid-phase microextraction (SPME) using DVB/CAR/PDMS sorbent coupled with gas chromatography-mass spectrometry was used to obtain the metabolomic information patterns. Urine samples were analyzed under both acid and alkaline pH, to profile a range of urinary components with different physicochemical properties. Multivariate statistics techniques were applied to bioanalytical data to visualize clusters of cases and to detect the VOCs able to differentiate autistic patients from healthy children. In particular, orthogonal projections to latent structures discriminant analysis (OPLS-DA) achieved very good separation between autistic and control groups under both acidic and alkaline pH, identifying discriminating metabolites. Among these, 3-methyl-cyclopentanone, 3-methyl-butanal, 2-methyl-butanal, and hexane under acid conditions, and 2-methyl-pyrazine, 2,3-dimethyl-pyrazine, and isoxazolo under alkaline pH had statistically higher levels in urine samples from autistic children than from the control group. Further investigation with a higher number of patients should be performed to outline the metabolic origins of these variables, define a possible association with ASDs, and verify the usefulness of these variables for early-stage diagnosis.
C1 [Cozzolino, Rosaria; Saggese, Paola; Martignetti, Antonella; Di Stasio, Michele; Boscaino, Floriana] CNR, Inst Food Sci, I-83100 Avellino, Italy.
   [De Magistris, Laura] Univ Naples 2, CIRANAD, I-80131 Naples, Italy.
   [Stocchero, Matteo] S IN Soluzioni Informat Srl, I-36100 Vicenza, Italy.
   [Malorni, Antonio] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, I-81100 Caserta, Italy.
   [Marotta, Rosa] Magna Graecia Univ Catanzaro, Dept Psychiat, I-88100 Catanzaro, Italy.
   [Malorni, Livia] Univ Naples 2, Dept Expt Med, Sect Hyg Occupat Med & Forens Med,Sch Med, I-80138 Naples, Italy.
RP Cozzolino, R (reprint author), CNR, Inst Food Sci, Via Roma 64, I-83100 Avellino, Italy.
EM rcozzolino@isa.cnr.it
CR Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
   Angley M, 2007, AUST FAM PHYSICIAN, V36, P741
   Banday KM, 2011, ANAL CHEM, V83, P5526, DOI 10.1021/ac200265g
   Barker M, 2003, J CHEMOMETR, V17, P166, DOI 10.1002/cem.785
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Bradstreet JJ, 2010, ALTERN MED REV, V15, P15
   Broadhurst DI, 2006, METABOLOMICS, V2, P171, DOI 10.1007/s11306-006-0037-z
   Chauhan A, 2004, LIFE SCI, V75, P2539, DOI 10.1016/j.lfs.2004.04.038
   De Angelis M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076993
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   Deng CH, 2004, J CHROMATOGR B, V808, P269, DOI 10.1016/j.jchromb.2004.05.015
   Dieterle F, 2006, ANAL CHEM, V78, P4281, DOI 10.1021/ac051632c
   Eriksson L., 2006, MULTIMEGAVARIATE DAT
   Fawcett T, 2006, PATTERN RECOGN LETT, V27, P861, DOI 10.1016/j.patrec.2005.10.010
   Goodacre R, 2007, METABOLOMICS, V3, P231, DOI 10.1007/s11306-007-0081-3
   Gu F, 2013, TRANSL PSYCHIAT, V3, P1
   Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1
   Jackson J.E., 1991, USERS GUIDE PRINCIPA
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kaluzna-Czaplinska J, 2012, NUTRITION, V28, P124, DOI 10.1016/j.nut.2011.08.002
   Kataoka H, 2000, J CHROMATOGR A, V880, P35, DOI 10.1016/S0021-9673(00)00309-5
   Kim YH, 2013, ANAL CHIM ACTA, V780, P46, DOI 10.1016/j.aca.2013.03.069
   Kushak RI, 2011, AUTISM, V15, P285, DOI 10.1177/1362361310369142
   Lancker F. van, 2010, Journal of Agricultural and Food Chemistry, V58, P2470
   LASZLO A, 1994, CLIN CHIM ACTA, V229, P205, DOI 10.1016/0009-8981(94)90243-7
   Lechner M, 2007, CURR MED CHEM, V14, P987, DOI 10.2174/092986707780362916
   Lindon JC, 2005, NAT BIOTECHNOL, V23, P833, DOI 10.1038/nbt0705-833
   London Eric, 2000, Environmental Health Perspectives, V108, P401, DOI 10.2307/3454527
   Madsen R, 2010, ANAL CHIM ACTA, V659, P23, DOI 10.1016/j.aca.2009.11.042
   MAGA JA, 1992, FOOD REV INT, V8, P479
   Mills GA, 2001, J CHROMATOGR B, V753, P259, DOI 10.1016/S0378-4347(00)00554-5
   Ming X, 2012, J PROTEOME RES, V11, P5856, DOI 10.1021/pr300910n
   Mitchell SC, 2002, J FOOD COMPOS ANAL, V15, P277, DOI 10.1006/jfca.2002.1068
   Mochalski P, 2009, J CHROMATOGR B, V877, P1856, DOI 10.1016/j.jchromb.2009.05.010
   Nicholson JK, 2008, NATURE, V455, P1054, DOI 10.1038/4551054a
   Nicolotti L, 2013, FOOD CHEM, V138, P1723, DOI 10.1016/j.foodchem.2012.11.086
   Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0
   Pawliszyn J., 2009, HDB SOLID PHASE MICR
   PERRY TL, 1978, BIOL PSYCHIAT, V13, P575
   Powers R., 2013, CURR METABOLOMICS, V1, P92
   Ratajczak HV, 2011, J IMMUNOTOXICOL, V8, P80, DOI 10.3109/1547691X.2010.538749
   ROLF LH, 1993, ACTA PSYCHIAT SCAND, V87, P312, DOI 10.1111/j.1600-0447.1993.tb03378.x
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Shirasu M, 2011, J BIOCHEM, V150, P257, DOI 10.1093/jb/mvr090
   Silva CL, 2011, BRIT J CANCER, V105, P1894, DOI 10.1038/bjc.2011.437
   Silva CL, 2012, TALANTA, V89, P360, DOI 10.1016/j.talanta.2011.12.041
   Smit BA, 2009, APPL MICROBIOL BIOT, V81, P987, DOI 10.1007/s00253-008-1758-x
   Tirouvanziam R, 2012, J AUTISM DEV DISORD, V42, P827, DOI 10.1007/s10803-011-1314-x
   Trygg J, 2002, J CHEMOMETR, V16, P119, DOI 10.1002/cem.695
   Trygg J, 2007, J PROTEOME RES, V6, P469, DOI 10.1021/pr060594q
   Veselkov KA, 2011, ANAL CHEM, V83, P5864, DOI 10.1021/ac201065j
   Wahl HG, 1999, J CHROMATOGR A, V847, P117, DOI 10.1016/S0021-9673(99)00017-5
   Wang L, 2011, BIOMARKERS, V16, P537, DOI 10.3109/1354750X.2011.598564
   Westerhuis JA, 2008, METABOLOMICS, V4, P81, DOI 10.1007/s11306-007-0099-6
   Wiklund S, 2008, ANAL CHEM, V80, P115, DOI 10.1021/ac0713510
   Williams BL, 2012, MBIO, V3, P1
   WINSBERG BG, 1980, NEUROPEDIATRICS, V11, P250, DOI 10.1055/s-2008-1071393
   Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e
   ZHANG ZY, 1993, ANAL CHEM, V65, P1843, DOI 10.1021/ac00062a008
   ZLATKIS A, 1981, CLIN CHEM, V27, P789
   Zurawicz E, 2013, BIOMED CHROMATOGR, V27, P1273, DOI 10.1002/bmc.2911
NR 62
TC 0
Z9 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1618-2642
EI 1618-2650
J9 ANAL BIOANAL CHEM
JI Anal. Bioanal. Chem.
PD JUL
PY 2014
VL 406
IS 19
BP 4649
EP 4662
DI 10.1007/s00216-014-7855-z
PG 14
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA AL5EE
UT WOS:000339155500009
PM 24828982
ER

PT J
AU Liu, YZ
   Li, BS
   Tan, RJ
   Zhu, XL
   Wang, YD
AF Liu, Yongzhuang
   Li, Bingshan
   Tan, Renjie
   Zhu, Xiaolin
   Wang, Yadong
TI A gradient-boosting approach for filtering de novo mutations in
   parent-offspring trios
SO BIOINFORMATICS
LA English
DT Article
ID GENERATION SEQUENCING DATA; INTELLECTUAL DISABILITY; SOMATIC MUTATION;
   DISCOVERY; AUTISM; SCHIZOPHRENIA; IDENTIFICATION; PATTERNS; MACHINE;
   RATES
AB Motivation: Whole-genome and -exome sequencing on parent-offspring trios is a powerful approach to identifying disease-associated genes by detecting de novo mutations in patients. Accurate detection of de novo mutations from sequencing data is a critical step in triobased genetic studies. Existing bioinformatic approaches usually yield high error rates due to sequencing artifacts and alignment issues, which may either miss true de novo mutations or call too many false ones, making downstream validation and analysis difficult. In particular, current approaches have much worse specificity than sensitivity, and developing effective filters to discriminate genuine from spurious de novo mutations remains an unsolved challenge. Results: In this article, we curated 59 sequence features in whole genome and exome alignment context which are considered to be relevant to discriminating true de novo mutations from artifacts, and then employed a machine-learning approach to classify candidates as true or false de novo mutations. Specifically, we built a classifier, named De Novo Mutation Filter (DNMFilter), using gradient boosting as the classification algorithm. We built the training set using experimentally validated true and false de novo mutations as well as collected false de novo mutations from an in-house large-scale exomesequencing project. We evaluated DNMFilter's theoretical performance and investigated relative importance of different sequence features on the classification accuracy. Finally, we applied DNMFilter on our in-house whole exome trios and one CEU trio from the 1000 Genomes Project and found that DNMFilter could be coupled with commonly used de novo mutation detection approaches as an effective filtering approach to significantly reduce false discovery rate without sacrificing sensitivity. Availability: The software DNMFilter implemented using a combination of Java and R is freely available from the website at http:// humangenome. duke. edu/software.
C1 [Liu, Yongzhuang; Tan, Renjie; Wang, Yadong] Harbin Inst Technol, Sch Comp Sci & Technol, Harbin 150001, Peoples R China.
   [Liu, Yongzhuang; Tan, Renjie; Zhu, Xiaolin] Duke Univ, Ctr Human Genome Variat, Durham, NC 27708 USA.
   [Li, Bingshan] Vanderbilt Univ, Dept Mol Physiol & Biophys, Ctr Human Genet Res, Nashville, TN 37235 USA.
RP Wang, YD (reprint author), Harbin Inst Technol, Sch Comp Sci & Technol, Harbin 150001, Peoples R China.
FU Epilepsy Phenome/Genome Project NIH [U01-NS053998]; Epi4K Project
   1-Epileptic Encephalopathies NIH [U01-NS077364]; Epi4K-Sequencing,
   Biostatistics and Bioinformatics Core NIH [U01-NS077303];
   Epi4K-Phenotyping and Clinical Informatics Core NIH [U01-NS077276];
   Natural Science Foundation of China [61173085, 61102149]; Governmental
   scholarship from China Scholarship Council (CSC)
FX The Epilepsy Phenome/Genome Project NIH grant U01-NS053998; Epi4K
   Project 1-Epileptic Encephalopathies NIH grant U01-NS077364;
   Epi4K-Sequencing, Biostatistics and Bioinformatics Core NIH grant
   U01-NS077303; Epi4K-Phenotyping and Clinical Informatics Core NIH grant
   U01-NS077276; Natural Science Foundation of China [grant numbers:
   61173085, 61102149]; Governmental scholarship from China Scholarship
   Council (CSC) (to Y.L. and R.T.).
CR Allen AS, 2013, NATURE, V501, P217, DOI 10.1038/nature12439
   Breiman L, 2001, MACH LEARN, V45, P5, DOI 10.1023/A:1010933404324
   Challis D, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-8
   Chiara M, 2012, NUCLEIC ACIDS RES, V40, DOI 10.1093/nar/gks606
   Chipman HA, 2010, ANN APPL STAT, V4, P266, DOI 10.1214/09-AOAS285
   Conrad DF, 2011, NAT GENET, V43, P712, DOI 10.1038/ng.862
   de Ligt J, 2012, NEW ENGL J MED, V367, P1921, DOI 10.1056/NEJMoa1206524
   DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
   Ding JR, 2012, BIOINFORMATICS, V28, P167, DOI 10.1093/bioinformatics/btr629
   Friedman J., 2009, ELEMENTS STAT LEARNI, V2nd
   Friedman JH, 2002, COMPUT STAT DATA AN, V38, P367, DOI 10.1016/S0167-9473(01)00065-2
   Friedman JH, 2001, ANN STAT, V29, P1189, DOI 10.1214/aos/1013203451
   Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
   Koboldt DC, 2012, GENOME RES, V22, P568, DOI 10.1101/gr.129684.111
   Le SQ, 2011, GENOME RES, V21, P952, DOI 10.1101/gr.113084.110
   Li BS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002944
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
   Meacham F, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-451
   Michaelson JJ, 2012, NAT METHODS, V9, P819, DOI [10.1038/nmeth.2085, 10.1038/NMETH.2085]
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nielsen R, 2011, NAT REV GENET, V12, P443, DOI 10.1038/nrg2986
   O'Fallon BD, 2013, BIOINFORMATICS, V29, P1361, DOI 10.1093/bioinformatics/btt172
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Ramu A, 2013, NAT METHODS, V10, P985, DOI 10.1038/nmeth.2611
   Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
   Robinson JT, 2011, NAT BIOTECHNOL, V29, P24, DOI 10.1038/nbt.1754
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
   Xu B, 2012, NAT GENET, V44, P1365, DOI 10.1038/ng.2446
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
NR 31
TC 1
Z9 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1367-4803
EI 1460-2059
J9 BIOINFORMATICS
JI Bioinformatics
PD JUL 1
PY 2014
VL 30
IS 13
BP 1830
EP 1836
DI 10.1093/bioinformatics/btu141
PG 7
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
   Computer Science, Interdisciplinary Applications; Mathematical &
   Computational Biology; Statistics & Probability
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Computer Science; Mathematical & Computational Biology; Mathematics
GA AL4SB
UT WOS:000339121900006
PM 24618463
ER

PT J
AU Tao, YL
   Wu, Q
   Guo, X
   Zhang, ZZ
   Shen, YY
   Wang, FD
AF Tao, Yunlong
   Wu, Qian
   Guo, Xin
   Zhang, Zhuzhen
   Shen, Yuanyuan
   Wang, Fudi
TI MBD5 regulates iron metabolism via methylation-independent genomic
   targeting of Fth1 through KAT2A in mice
SO BRITISH JOURNAL OF HAEMATOLOGY
LA English
DT Article
DE haemochromatosis; iron overload; epigenetic; histone acetylation; DNA
   methylation
ID HISTONE DEACETYLASE COMPLEX; AUTISM SPECTRUM DISORDER; BINDING-PROTEIN
   MBD1; H-FERRITIN GENE; TRANSCRIPTIONAL REPRESSION; DEVELOPMENTAL DELAY;
   2Q23.1 MICRODELETION; CELLS; MOUSE; HOMEOSTASIS
AB Ferritin plays important roles in iron metabolism and controls iron absorption in the intestine. The ferritin subunits ferritin heavy chain (Fth1) and ferritin light chain (Ftl1) are tightly regulated at both the transcriptional and post-transcriptional levels. However, mechanisms of maintaining stable, basal expression of Fth1 are poorly understood. Here, we show that global deletion of Mbd5 in mice induces an iron overload phenotype. Liver and serum iron levels in Mbd5(-/-) mice were 3.2-fold and 1.5-fold higher respectively, than wild-type littermates; moreover, serum ferritin was increased >5-fold in the Mbd5(-/-) mice. Mbd5 encodes a member of the methyl-CpG binding domain family; however, the precise function of this gene is poorly understood. Here, we found that intestinal Fth1 mRNA levels were decreased in Mbd5(-/-) mice. Loss of Fth1 expression in the intestine could lead to iron over-absorption. Furthermore, deleting Mbd5 specifically in the intestine resulted in a phenotype similar to that of conditional deletion of Fth1 mice. An Fth1 promoter-report luciferase assay indicated that overexpression of Mbd5 enhanced Fth1 transcription in a dose-dependent manner. Histone H4 acetylation of the Fth1 promoter was reduced in the intestine of Mbd5(-/-) mice and further analysis showed that histone acetyltransferase KAT2A was essential for MBD5-induced Fth1 transcription.
C1 [Tao, Yunlong; Wu, Qian; Guo, Xin; Zhang, Zhuzhen; Shen, Yuanyuan] Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Grad Sch, Shanghai, Peoples R China.
   [Tao, Yunlong; Wu, Qian; Guo, Xin; Zhang, Zhuzhen; Wang, Fudi] Zhejiang Univ, Sch Publ Hlth, Dept Nutr, Inst Nutr & Food Safety,Collaborat Innovat Ctr Di, Hangzhou 310058, Zhejiang, Peoples R China.
RP Wang, FD (reprint author), Zhejiang Univ, Sch Publ Hlth, Dept Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM fwang@zju.edu.cn
FU Ministry of Science and Technology of China [2011CB966200,
   2012BAD33B05]; National Natural Science Foundation of China [31030039,
   31225013, 31330036]; Distinguished Professorship Programme of Zhejiang
   University
FX The authors would like to thank Dr. Guoliang Xu (Institute of
   Biochemistry and Cell Biology, SIBS, CAS) for sharing his
   Mbd5<SUP>-/-</SUP> mice and Mbd5 expression plasmids, Dr. Yoshiaki Tsuji
   (North Carolina State University) for providing the Fth1-promoter 4.8 kb
   pGL3 plasmids, and Pere Puigserver (Harvard Medical School) for
   providing KAT2A expression plasmid. This study was supported by research
   grants from the Ministry of Science and Technology of China
   (2011CB966200, and 2012BAD33B05) and the National Natural Science
   Foundation of China (31030039, 31225013 and 31330036). This study was
   also supported by the Distinguished Professorship Programme of Zhejiang
   University (to FW).
CR Angrisano T, 2006, NUCLEIC ACIDS RES, V34, P364, DOI 10.1093/nar/gkj400
   AROSIO P, 1976, CANCER RES, V36, P1735
   BEVILACQUA MA, 1995, BIOCHEM J, V311, P769
   Bogdanovic O, 2009, CHROMOSOMA, V118, P549, DOI 10.1007/s00412-009-0221-9
   Bonnet C, 2013, EUR J HUM GENET, V21, P1457, DOI 10.1038/ejhg.2013.22
   Chung BHY, 2011, AM J MED GENET A, V155A, P424, DOI 10.1002/ajmg.a.33821
   Cukier HN, 2012, AUTISM RES, V5, P385, DOI 10.1002/aur.1251
   Darshan D, 2009, HEPATOLOGY, V50, P852, DOI 10.1002/hep.23058
   Donovan A, 2000, NATURE, V403, P776
   Du YR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047358
   Faniello MC, 1999, J BIOL CHEM, V274, P7623, DOI 10.1074/jbc.274.12.7623
   Ferreira C, 2000, J BIOL CHEM, V275, P3021, DOI 10.1074/jbc.275.5.3021
   Fujita N, 2000, MOL CELL BIOL, V20, P5107, DOI 10.1128/MCB.20.14.5107-5118.2000
   Gunshin H, 1997, NATURE, V388, P482, DOI 10.1038/41343
   Hentze MW, 2010, CELL, V142, P24, DOI 10.1016/j.cell.2010.06.028
   Hodge JC, 2014, MOL PSYCHIATR, V19, P368, DOI 10.1038/mp.2013.42
   Kautz L, 2008, BLOOD, V112, P1503, DOI 10.1182/blood-2008-03-143354
   Kondo E, 2005, MOL CELL BIOL, V25, P4388, DOI 10.1128/MCB.25.11.4388-4396.2005
   KWAK EL, 1995, J BIOL CHEM, V270, P15285
   Ladha S, 2012, CLIN GENET, V81, P363, DOI 10.1111/j.1399-0004.2011.01836.x
   Laget S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011982
   Lerin C, 2006, CELL METAB, V3, P429, DOI 10.1016/j.cmet.2006.04.013
   Madison BB, 2002, J BIOL CHEM, V277, P33275, DOI 10.1074/jbc.M204935200
   McKie AT, 2000, MOL CELL, V5, P299, DOI 10.1016/S1097-2765(00)80425-6
   MOOS T, 1993, HISTOCHEMISTRY, V99, P471
   Muckenthaler MU, 2008, ANNU REV NUTR, V28, P197, DOI 10.1146/annurev.nutr.28.061807.155521
   Mullegama SV, 2014, EUR J HUM GENET, V22, P57, DOI 10.1038/ejhg.2013.67
   Nan XS, 1998, NATURE, V393, P386
   Nemeth E, 2004, SCIENCE, V306, P2090, DOI 10.1126/science.1104742
   Ng HH, 1999, NAT GENET, V23, P58
   Niederkofler V, 2005, J CLIN INVEST, V115, P2180, DOI 10.1172/JCI25683
   Noh GJ, 2012, EUR J MED GENET, V55, P354, DOI 10.1016/j.ejmg.2012.05.003
   Picard V, 1996, BLOOD, V87, P2057
   Picard V, 1998, J BIOL CHEM, V273, P15382, DOI 10.1074/jbc.273.25.15382
   Postic C, 1999, J BIOL CHEM, V274, P305, DOI 10.1074/jbc.274.1.305
   Roth SY, 2001, ANNU REV BIOCHEM, V70, P81, DOI 10.1146/annurev.biochem.70.1.81
   Saito M, 2002, J BIOL CHEM, V277, P35434, DOI 10.1074/jbc.M203455200
   Shichiji M, 2013, AM J MED GENET A, V161A, P850, DOI 10.1002/ajmg.a.35768
   Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011
   Torti FM, 2002, BLOOD, V99, P3505, DOI 10.1182/blood.V99.10.3505
   Tsuji Y, 2000, MOL CELL BIOL, V20, P5818, DOI 10.1128/MCB.20.16.5818-5827.2000
   TSUJI Y, 1995, MOL CELL BIOL, V15, P5152
   Vanoaica L, 2010, CELL METAB, V12, P273, DOI 10.1016/j.cmet.2010.08.003
   Villa R, 2006, P NATL ACAD SCI USA, V103, P1400, DOI 10.1073/pnas.0509343103
   Vulpe CD, 1999, NAT GENET, V21, P195
   Wang W, 2010, BIOCHEM PHARMACOL, V80, P316, DOI 10.1016/j.bcp.2010.04.008
   Williams SR, 2010, EUR J HUM GENET, V18, P436, DOI 10.1038/ejhg.2009.199
   Zhang ZZ, 2011, BLOOD, V118, P1912, DOI 10.1182/blood-2011-01-330324
   Zhou XY, 1998, P NATL ACAD SCI USA, V95, P2492, DOI 10.1073/pnas.95.5.2492
NR 49
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1048
EI 1365-2141
J9 BRIT J HAEMATOL
JI Br. J. Haematol.
PD JUL
PY 2014
VL 166
IS 2
BP 279
EP 291
DI 10.1111/bjh.12863
PG 13
WC Hematology
SC Hematology
GA AL7VO
UT WOS:000339344700017
PM 24750026
ER

PT J
AU Hurt, E
   Arnold, LE
   Lofthouse, N
AF Hurt, Elizabeth
   Arnold, L. Eugene
   Lofthouse, Nicholas
TI Quantitative EEG Neurofeedback for the Treatment of Pediatric
   Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorders,
   Learning Disorders, and Epilepsy
SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Neurofeedback; Neurotherapy; EEG biofeedback; Quantitative EEG; ADHD;
   Autism spectrum disorders; Learning disorders; Epilepsy
ID RANDOMIZED CONTROLLED-TRIAL; DISABLED CHILDREN; CLINICAL-TRIAL; ADHD;
   BIOFEEDBACK; IMPULSIVITY; METAANALYSIS; POTENTIALS
AB Neurofeedback (NF) using surface electroencephalographic signals has been used to treat various child psychiatric disorders by providing patients with video/audio information about their brain's electrical activity in real-time. Research data are reviewed and clinical recommendations are made regarding NF treatment of youth with attention deficit/hyperactivity disorder, autism, learning disorders, and epilepsy. Most NF studies are limited by methodological issues, such as failure to use or test the validity of a full-blind or sham NF. The safety of NF treatment has not been thoroughly investigated in youth or adults, although clinical experience suggests reasonable safety.
C1 [Hurt, Elizabeth] Wright State Univ, Sch Profess Psychol, Dayton, OH 45435 USA.
   [Arnold, L. Eugene] Ohio State Univ, Nisonger Ctr, Dept Psychiat, Columbus, OH 43210 USA.
   [Lofthouse, Nicholas] Sch Profess Psychol, Columbus, OH 43235 USA.
RP Hurt, E (reprint author), Wright State Univ, Sch Profess Psychol, 053 Student Union, Dayton, OH 45435 USA.
EM Beth.Hurt@wright.edu
CR American Academy of Pediatrics, 2012, EV BAS CHILD AD PSYC
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Arnold LE, 2013, J ATTEN DISORD, V17, P410, DOI 10.1177/1087054712446173
   Arns M, 2012, APPL PSYCHOPHYS BIOF, V37, P171, DOI 10.1007/s10484-012-9191-4
   Arns M, 2009, CLIN EEG NEUROSCI, V40, P180
   Arns M, 2010, J NEUROTHER, V14, P291, DOI 10.1080/10874208.2010.523356
   Bakhshayesh AR, 2011, EUR CHILD ADOLES PSY, V20, P481, DOI 10.1007/s00787-011-0208-y
   Barry RJ, 2003, CLIN NEUROPHYSIOL, V114, P171, DOI 10.1016/S1388-2457(02)00362-0
   Becerra J, 2006, CLIN EEG NEUROSCI, V37, P198
   Berger H, 1929, ARCH PSYCHIAT NERVEN, V87, P527, DOI 10.1007/BF01797193
   Breteler MHM, 2010, APPL PSYCHOPHYS BIOF, V35, P5, DOI 10.1007/s10484-009-9105-2
   Breteler MHM, 2010, APPL PSYCHOPHYS BIOF, V35, P187, DOI 10.1007/s10484-010-9129-7
   Coben R., 2013, IMAGING BRAIN AUTISM, P349
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   deBeus RJ, 2011, NEUROFEEDBACK AND NEUROMODULATION TECHNIQUES AND APPLICATIONS, P127, DOI 10.1016/B978-0-12-382235-2.00005-6
   Donovan HS, 2009, WESTERN J NURS RES, V31, P983, DOI 10.1177/0193945909338488
   Drechsler R, 2007, BEHAV BRAIN FUNCT, V3, DOI 10.1186/1744-9081-3-35
   Durup G, 1935, ANN PSYCHOL, V36, P1
   Fernandez T, 2003, CLIN ELECTROENCEPHAL, V34, P145
   Fernandez T, 2012, BRAIN COGNITION, V80, P74, DOI 10.1016/j.bandc.2012.04.008
   Fernandez T, 2007, APPL PSYCHOPHYS BIOF, V32, P169, DOI 10.1007/s10484-007-9044-8
   Gevensleben H, 2009, J CHILD PSYCHOL PSYC, V50, P780, DOI 10.1111/j.1469-7610.2008.02033.x
   Gevensleben H, 2009, INT J PSYCHOPHYSIOL, V74, P149, DOI 10.1016/j.ijpsycho.2009.08.005
   Hammond D.C., 2011, J NEUROTHER, V15, P305, DOI DOI 10.1080/10874208.2011.623090
   Holtmann M, 2011, DEV MED CHILD NEUROL, V53, P986, DOI 10.1111/j.1469-8749.2011.04043.x
   Holtmann M, 2009, KINDH ENTWICKL, V18, P95, DOI 10.1026/0942-5403.18.2.95
   Kamiya J., 2011, J NEUROTHER, V15, P65, DOI 10.1080/10874208.2011.545764
   Arnold LE, 2013, J ATTEN DISORD, V17, P420, DOI 10.1177/1087054713482580
   Kouijzer MEJ, 2009, RES AUTISM SPECT DIS, V3, P496, DOI 10.1016/j.rasd.2008.10.003
   Kouijzer MEJ, 2010, RES AUTISM SPECT DIS, V4, P386, DOI 10.1016/j.rasd.2009.10.007
   Kouijzer MEJ, 2009, RES AUTISM SPECT DIS, V3, P145, DOI 10.1016/j.rasd.2008.05.001
   Kouijzer MEJ, 2013, APPL PSYCHOPHYS BIOF, V38, P17, DOI 10.1007/s10484-012-9204-3
   La Vague TJ, 2001, APPL PSYCHOPHYS BIOF, V26, P25
   Lansbergen MM, 2010, J NEURAL TRANSM, V118, P275
   LANTZ D, 1988, EPILEPSIA, V29, P163, DOI 10.1111/j.1528-1157.1988.tb04414.x
   Leins U, 2007, APPL PSYCHOPHYS BIOF, V32, P73, DOI 10.1007/s10484-007-9031-0
   Levesque J, 2006, NEUROSCI LETT, V394, P216, DOI 10.1016/j.neulet.2005.10.100
   Linden M, 1996, BIOFEEDBACK SELF-REG, V21, P35, DOI 10.1007/BF02214148
   Lofthouse N, 2010, J NEUROTHER, V14, P301, DOI 10.1080/10874208.2010.523340
   Lofthouse N, 2012, J ATTEN DISORD, V16, P351, DOI 10.1177/1087054711427530
   Lofthouse N, 2012, CURR PSYCHIAT REP, V14, P536, DOI 10.1007/s11920-012-0301-z
   Loomis AL, 1936, J EXP PSYCHOL, V19, P249, DOI 10.1037/h0062089
   LUBAR JF, 1981, ARCH NEUROL-CHICAGO, V38, P700
   Monastra VJ, 2002, APPL PSYCHOPHYS BIOF, V27, P231, DOI 10.1023/A:1021018700609
   Monastra VJ, 2005, APPL PSYCHOPHYS BIOF, V30, P95, DOI 10.1007/s10484-005-4305-x
   Jensen PS, 1999, ARCH GEN PSYCHIAT, V56, P1073
   Nelson DV, 2010, PAIN MED, V11, P912, DOI 10.1111/j.1526-4637.2010.00862.x
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   OMIZO MM, 1982, J LEARN DISABIL, V15, P414
   Perreau-Linck E, 2010, J NEUROTHERAPY, V14, P229
   Pineda JA, 2008, RES AUTISM SPECT DIS, V2, P557, DOI 10.1016/j.rasd.2007.12.003
   Rivera E, 1980, EXCEPT CHILDREN, V27, P41
   Robbins J, 2008, SYMPHONY BRAIN EVOLU
   ROCKSTROH B, 1993, EPILEPSY RES, V14, P63, DOI 10.1016/0920-1211(93)90075-I
   Sherlin L, 2011, J NEUROTHER, V15, P292, DOI DOI 10.1080/10874208.2011.623089
   Sherlin L., 2010, J NEUROTHERAPY, V14, P66, DOI DOI 10.1080/10874201003773880
   Sherlin L, 2010, J NEUROTHER, V14, P307, DOI 10.1080/10874208.2010.523350
   Sonuga-Barke EJS, 2013, AM J PSYCHIAT, V170, P275, DOI 10.1176/appi.ajp.2012.12070991
   Sterman MB, 1963, THESIS U CALIF, P80
   Sterman MB, 1969, ELECTROENCEPHALOGRAP, p[1, 69]
   Sterman MB, 2000, CLIN ELECTROENCEPHAL, V31, P45
   STERMAN MB, 1972, ELECTROEN CLIN NEURO, V33, P89, DOI 10.1016/0013-4694(72)90028-4
   Sterman MB, 2010, J NEUROTHERAPY, V14, P293, DOI 10.1080/10874208.2010.523367
   Strehl U, 2006, PEDIATRICS, V118, P1530
   Tan G, 2009, CLIN EEG NEUROSCI, V40, P173
   US Preventive Services Task Force, 2007, LEV CERT RES EV REC
   Walker JE, 2005, CHILD ADOL PSYCH CL, V14, P163, DOI 10.1016/j.chc.2004.07.009
NR 67
TC 1
Z9 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1056-4993
EI 1558-0490
J9 CHILD ADOL PSYCH CL
JI Child Adolesc. Psychiatr. N. Am.
PD JUL
PY 2014
VL 23
IS 3
BP 465
EP +
DI 10.1016/j.chc.2014.02.001
PG 23
WC Psychiatry
SC Psychiatry
GA AL8TH
UT WOS:000339411900003
PM 24975622
ER

PT J
AU Yinger, OS
   Gooding, L
AF Yinger, Olivia Swedberg
   Gooding, Lori
TI Music Therapy and Music Medicine for Children and Adolescents
SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Music therapy; Music medicine; Child and adolescent psychiatry; Mental
   health; Research
ID GROUP-PSYCHOTHERAPY; SELF-ESTEEM; AUTISM; PROGRAM; SKILLS; BEHAVIOR;
   INTERVENTIONS; METAANALYSIS; PREDICTORS; DISORDERS
AB This article summarizes the research on music therapy and music medicine for children and adolescents with diagnoses commonly treated by psychiatrists. Music therapy and music medicine are defined, effects of music on the brain are described, and music therapy research in psychiatric treatment is discussed. Music therapy research with specific child/adolescent populations is summarized, including disorders usually diagnosed in childhood, substance abuse, mood/anxiety disorders, and eating disorders. Clinical implications are listed, including suggestions for health care professionals seeking to use music medicine techniques. Strengths and weaknesses of music therapy treatment are discussed, as well as areas for future research.
C1 [Yinger, Olivia Swedberg; Gooding, Lori] Univ Kentucky, Coll Fine Arts, Sch Mus, Lexington, KY 40506 USA.
RP Yinger, OS (reprint author), Univ Kentucky, Coll Fine Arts, Sch Mus, 105 Fine Arts, Lexington, KY 40506 USA.
EM olivia.yinger@uky.edu
CR American Music Therapy Association, 2011, AMTA 2011 MEMB SURV
   American Music Therapy Association, 2011, PROF REQ MUS THER
   American Music Therapy Association, 2011, WHAT IS MUS THER
   Baker F, 2008, AUSTRALAS PSYCHIATRY, V16, P284, DOI 10.1080/10398560701879589
   Blood AJ, 2001, P NATL ACAD SCI USA, V98, P11818, DOI 10.1073/pnas.191355898
   Boso M, 2007, J ALTERN COMPLEM MED, V13, P709, DOI 10.1089/acm.2006.6334
   Brown LS, 2012, J MUSIC THER, V49, P335
   Cassity M. D., 2007, MUSIC THERAPY PERSPE, V25, P86
   Cassity MD., 1976, J MUSIC THER, V8, P66
   Choi AN, 2010, EVID-BASED COMPL ALT, V7, P213, DOI 10.1093/ecam/nem182
   Choi CMH, 2010, J MUSIC THER, V47, P380
   Chong HJ, 2010, ART PSYCHOTHER, V37, P190, DOI 10.1016/j.aip.2010.03.004
   Cripe F., 1986, J MUSIC THER, V23, P30
   Darrow AA., 2004, INTRO APPROACHES MUS
   DARROW AA, 1993, J RES MUSIC EDUC, V41, P93, DOI 10.2307/3345402
   de l'Etoile SK, 2002, ART PSYCHOTHER, V29, P69, DOI 10.1016/S0197-4556(02)00139-9
   Dileo C, 2005, MED MUSIC THERAPY ME
   Dingle GA, 2008, DRUG ALCOHOL REV, V27, P190, DOI 10.1080/09595230701829371
   Edwards Jane, 2006, Irish Journal of Psychological Medicine, V23, P33
   EIDSON CE, 1989, J MUSIC THER, V26, P206
   Emanuele E, 2009, ACT NERV SUPER REDIV, V51, P142
   Field T, 1998, ADOLESCENCE, V33, P109
   Gallant W, 1997, CANADIAN J MUSIC THE, V5, P67
   Gardstrom S., 2003, INVESTIGATION MEANIN
   Gold C, 2001, J MUSIC THER, V10, P17
   Gold C, 2009, CLIN PSYCHOL REV, V29, P193, DOI 10.1016/j.cpr.2009.01.001
   Gold C, 2004, J CHILD PSYCHOL PSYC, V45, P1054, DOI 10.1111/j.1469-7610.2004.t01-1-00298.x
   Gold C, 2007, PSYCHOL PSYCHOTHER-T, V80, P577, DOI 10.1348/147608307X204396
   Gold C, 2007, PSYCHOTHER RES, V17, P289, DOI 10.1080/10503300600607886
   Gold C, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004381.pub2
   GOLDBERG FS, 1988, GROUP, V12, P145, DOI 10.1007/BF01456564
   Gooding L, 2012, SOUTH MED J, V105, P486, DOI 10.1097/SMJ.0b013e318264450c
   Gooding LF, 2011, J MUSIC THER, V48, P440
   Haines JH, 1989, MUSIC THERAPY, V8, P78
   Hanser S., 1974, J MUSIC THER, V11, P220
   Heaney J., 1992, J MUSIC THER, V29, P70
   HENDERSON SM, 1983, J MUSIC THER, V20, P14
   Hilliard R. E., 2001, MUSIC THERAPY PERSPE, V19, P109
   Hilliard RE, 2007, J MUSIC THER, V44, P123
   Hilliard RE, 2001, J MUSIC THER, V38, P291
   Howard AA, 1997, J POETRY THERAPY, V11, P81
   Jackson NA, 2003, J MUSIC THER, V40, P302
   JAMES MR, 1988, J MUSIC THER, V25, P206
   Jellison JA, 2000, AM MUSIC THERAPY ASS, P199
   JOHNSON ER, 1981, J MUSIC THER, V18, P137
   Jones JD, 2005, J MUSIC THER, V42, P94
   Justice RW, 1994, MUSIC THER PERSPECT, V12, P104
   Kaplan RS, 2005, J MUSIC THER, V42, P2
   Kim J, 2009, AUTISM, V13, P389, DOI 10.1177/1362361309105660
   Kim J, 2008, J AUTISM DEV DISORD, V38, P1758, DOI 10.1007/s10803-008-0566-6
   KIVLAND MJ, 1986, J MUSIC THER, V23, P25
   Koelsch S, 2009, ANN NY ACAD SCI, V1169, P374, DOI 10.1111/j.1749-6632.2009.04592.x
   Koelsch S, 2010, MUSIC PERCEPT, V27, P307, DOI 10.1525/MP.2010.27.4.307
   Lin ST, 2011, HARVARD REV PSYCHIAT, V19, P36
   McFerran K., 2005, VOICES WORLD FORUM M, V5
   McFerran K, 2006, EUR EAT DISORD REV, V14, P397, DOI 10.1002/erv.746
   McIntyre J., 2007, MUSIC THERAPY TODAY, V8, P56
   McQueen C, 1975, BRIT J MUSIC THERAPY, V6, P2
   Menon V, 2005, NEUROIMAGE, V28, P175, DOI 10.1016/j.neuroimage.2005.05.053
   Montello L, 1998, J MUSIC THER, V35, P49
   Mossler K, 2012, ART PSYCHOTHER, V39, P333, DOI 10.1016/j.aip.2012.05.002
   Reschke-Hernandez AE, 2011, J MUSIC THER, V48, P169
   Rickson DJ, 2006, J MUSIC THER, V43, P39
   Rickson DJ, 2003, J MUSIC THER, V40, P293
   Robarts JZ, 2000, NORDIC J MUSIC THERA, V9, P3
   Ross S, 2008, J ADDICT DIS, V27, P41, DOI 10.1300/J069v27n01_05
   Salimpoor VN, 2011, NAT NEUROSCI, V14, P257, DOI 10.1038/nn.2726
   Sasaki A, 2006, J NEUROSCI, V26, P9010, DOI 10.1523/JNEUROSCI.1335-06.2006
   SCHWANTES M., 2010, MUSIC THER PERSPECT, V28, P22
   Silverman MJ, 2010, ART PSYCHOTHER, V37, P264, DOI 10.1016/j.aip.2010.05.002
   Silverman MJ, 2007, J MUSIC THER, V44, P388
   Silverman MJ., 2009, MUSIC THERAPY PERSPE, V27, P115
   Silverman MJ, 2011, J MUSIC THER, V48, P103
   Silverman MJ, 2004, ART PSYCHOTHER, V31, P291, DOI 10.1016/j.aip.2004.09.008
   Simpson J, 2004, MUSIC THERAPY REIMBU
   Slotoroff C., 1994, MUSIC THERAPY PERSPE, V12, P111
   Snow S, 2010, CAN J MUS THER, V16, P12
   Standley JM, 2010, MUSIC THERAPY PREMAT, P116
   Strehlow G, 2009, NORD J MUSIC THER, V18, P167, DOI 10.1080/08098130903062397
   Taylor D, 2004, BIOMEDICAL FDN MUSIC
   Teague AK, 2006, MUSIC THER PERSPECT, V24, P80
   Uher R, 2005, BIOL PSYCHIAT, V58, P990, DOI 10.1016/j.biopsych.2005.06.001
   Ulrich G, 2007, ACTA PSYCHIAT SCAND, V116, P362, DOI 10.1111/j.1600-0447.2007.01073.x
   Wan CY, 2010, BRAIN RES BULL, V82, P161, DOI 10.1016/j.brainresbull.2010.04.010
   Whipple J, 2004, J MUSIC THER, V41, P90
   Wooten M. A., 1992, MUSIC THERAPY PERSPE, V10, P93
NR 86
TC 0
Z9 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1056-4993
EI 1558-0490
J9 CHILD ADOL PSYCH CL
JI Child Adolesc. Psychiatr. N. Am.
PD JUL
PY 2014
VL 23
IS 3
BP 535
EP +
DI 10.1016/j.chc.2013.03.003
PG 20
WC Psychiatry
SC Psychiatry
GA AL8TH
UT WOS:000339411900005
PM 24975624
ER

PT J
AU Terzian, ALB
   Micale, V
   Wotjak, CT
AF Terzian, Ana Luisa B.
   Micale, Vincenzo
   Wotjak, Carsten T.
TI Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic
   neurons differentially gate sex-dependent social interest in mice
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE CB1; depression; GABA; glutamate; sexual interest; social behavior
ID ENDOCANNABINOID SYSTEM; ANXIETY RESPONSES; BIMODAL CONTROL; KNOCKOUT
   MICE; ANIMAL-MODELS; CB1; BEHAVIOR; DEPRESSION; FEAR; AROUSAL
AB Abnormalities in social behavior are found in almost all psychiatric disorders, such as anxiety, depression, autism, and schizophrenia. Thus, comprehension of the neurobiological basis of social interaction is important for a better understanding of numerous pathologies and improved treatments. Several findings have suggested that an alteration of cannabinoid receptor type 1 (CB1) receptor function could be involved in the pathophysiology of such disorders. However, the role of CB1 receptors is still unclear, and their localisation on different neuronal subpopulations may produce distinct outcomes. To dissect the role of CB1 receptors in different neuronal populations, we used male knockout mice and their respective control littermates [total deletion (CB1(-/-)); specific deletion on cortical glutamatergic neurons (Glu-CB1(-/-)) or on GABAergic interneurons (GABA-CB1(-/-)), and wild-type (WT) mice treated with the CB1 antagonist/inverse agonist SR141716A (3 mg/kg). Mice were required to perform different social tasks - direct social interaction and social investigation. Direct interaction of two male mice was not modified in any group; however, when they were paired with females, Glu-CB1(-/-) mice showed reduced interaction. Also, exploration of the male stimulus subject in the three-chamber social investigation test was almost unaffected. The situation was completely different when a female was used as the stimulus subject. In this case, Glu-CB1(-/-) mice showed reduced interest in the social stimulus, mimicking the phenotype of CB1(-/-) or WT mice treated with SR141716A. GABA-CB1(-/-) mice showed the opposite phenotype, by spending more time investigating the social stimulus. In conclusion, we provide evidence that CB1 receptors specifically modulate the social investigation of female mice in a neuronal subtype-specific manner.
C1 [Terzian, Ana Luisa B.; Micale, Vincenzo; Wotjak, Carsten T.] Max Planck Inst Psychiat, Res Grp Neural Plast, D-80804 Munich, Germany.
   [Terzian, Ana Luisa B.] Univ Munich, Grad Sch Syst Neurosci, Munich, Germany.
   [Micale, Vincenzo] Masaryk Univ, Cent European Inst Technol CEITEC, Brno, Czech Republic.
RP Wotjak, CT (reprint author), Max Planck Inst Psychiat, Res Grp Neural Plast, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM wotjak@mpipsykl.mpg.de
FU CNPq [290008/2009-3]; ECNP Research Grant for Young Scientists; project
   'CEITEC - Central European Institute of Technology' from the European
   Regional Development Fund [CZ.1.05/1.1.00/02.0068]
FX A. L. Terzian is supported by a CNPq scholarship (process
   290008/2009-3), and V. Micale was supported by an ECNP Research Grant
   for Young Scientists 2010 and by the project 'CEITEC - Central European
   Institute of Technology' (CZ.1.05/1.1.00/02.0068) from the European
   Regional Development Fund.
CR Ace J. K., 2007, SEX HEALTH, V1, P301
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bellocchio L, 2010, NAT NEUROSCI, V13, P281, DOI 10.1038/nn.2494
   Choleris E, 2009, FRONT NEUROENDOCRIN, V30, P442, DOI 10.1016/j.yfrne.2009.05.003
   Crawley JN, 2007, NEUROPEPTIDES, V41, P145, DOI 10.1016/j.npep.2007.02.002
   Cryan JF, 2005, NAT REV DRUG DISCOV, V4, P775, DOI 10.1038/nrd1825
   Davidson RJ, 2000, SCIENCE, V289, P591, DOI 10.1126/science.289.5479.591
   Ferrari F, 2000, PHYSIOL BEHAV, V69, P547, DOI 10.1016/S0031-9384(00)00214-6
   File SE, 2003, EUR J PHARMACOL, V463, P35, DOI 10.1016/S0014-2999(03)01273-1
   Gorzalka B. B., 2006, ANN REV SEX RES, V17, P132
   Haller J, 2004, EUR J NEUROSCI, V19, P1906, DOI 10.1111/j.1460.9568.2004.03293.x
   Haring M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026617
   Hill MN, 2010, J NEUROSCI, V30, P14980, DOI 10.1523/JNEUROSCI.4283-10.2010
   Jacob W, 2009, GENES BRAIN BEHAV, V8, P685, DOI 10.1111/j.1601-183X.2009.00512.x
   Kalmbach DA, 2012, J SEX MED, V9, P505, DOI 10.1111/j.1743-6109.2011.02533.x
   Kamprath K, 2009, GENES BRAIN BEHAV, V8, P203, DOI 10.1111/j.1601-183X.2008.00463.x
   Klein C, 2012, J SEX MED, V9, P1588, DOI 10.1111/j.1743-6109.2012.02708.x
   Lafenetre P, 2009, NEUROPHARMACOLOGY, V57, P715, DOI 10.1016/j.neuropharm.2009.07.014
   Laurent SM, 2009, CLIN PSYCHOL REV, V29, P573, DOI 10.1016/j.cpr.2009.06.007
   Litvin Y, 2013, GENES BRAIN BEHAV, V12, P479, DOI 10.1111/gbb.12045
   Maldonado R., 2002, J NEUROSCI, V22, P3328
   Marsicano G, 1999, EUR J NEUROSCI, V11, P4213, DOI 10.1046/j.1460-9568.1999.00847.x
   Marsicano G, 2002, NATURE, V418, P530, DOI 10.1038/nature00839
   Martin M, 2002, PSYCHOPHARMACOLOGY, V159, P379, DOI 10.1007/s00213-001-0946-5
   Metna-Laurent M, 2012, J NEUROSCI, V32, P7109, DOI 10.1523/JNEUROSCI.1054-12.2012
   Micale V, 2013, CELL TISSUE RES, V354, P309, DOI 10.1007/s00441-013-1692-9
   Micale V, 2013, PHARMACOL THERAPEUT, V138, P18, DOI 10.1016/j.pharmthera.2012.12.002
   Monory Krisztina, 2007, PLoS Biol, V5, pe269, DOI 10.1371/journal.pbio.0050269
   Monory K, 2006, NEURON, V51, P455, DOI 10.1016/j.neuron.2006.07.006
   Moreira FA, 2012, NEUROSCIENCE, V204, P186, DOI 10.1016/j.neuroscience.2011.08.046
   Moreira FA, 2010, CURR TOP BEHAV NEURO, V2, P429, DOI 10.1007/7854_2009_16
   Murray RM, 2007, NAT REV NEUROSCI, V8, P885, DOI 10.1038/nrn2253
   Pankevich DE, 2004, J NEUROSCI, V24, P9451, DOI 10.1523/JNEUROSCI.2376-04.2004
   Pare WP, 2000, BRAIN RES BULL, V53, P759, DOI 10.1016/S0361-9230(00)00362-2
   Piomelli D, 2003, NAT REV NEUROSCI, V4, P873, DOI 10.1038/nrn1247
   Rey AA, 2012, NEUROPSYCHOPHARMACOL, V37, P2624, DOI 10.1038/npp.2012.123
   Ruehle S., 2011, J PSYCHOPHARMACOL, V26, P23
   SHRENKER P, 1985, PHARMACOL BIOCHEM BE, V22, P415, DOI 10.1016/0091-3057(85)90042-5
   Strom J. O., 2012, J VIS EXP, V64, pe4013
   Terzian A. L., 2011, FRONT BEHAV NEUROSCI, V5, P1
   Viveros MP, 2005, PHARMACOL BIOCHEM BE, V81, P331, DOI 10.1016/j.pbb.2005.01.029
   WILLNER P, 1991, TRENDS PHARMACOL SCI, V12, P131, DOI 10.1016/0165-6147(91)90529-2
   Zimmer A, 1999, P NATL ACAD SCI USA, V96, P5780, DOI 10.1073/pnas.96.10.5780
NR 43
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD JUL
PY 2014
VL 40
IS 1
BP 2293
EP 2298
DI 10.1111/ejn.12561
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA AL6QJ
UT WOS:000339257400013
PM 24698342
ER

PT J
AU Yangngam, S
   Plong-On, O
   Sripo, T
   Roongpraiwan, R
   Hansakunachai, T
   Wirojanan, J
   Sombuntham, T
   Ruangdaraganon, N
   Limprasert, P
AF Yangngam, Supaporn
   Plong-On, Oradawan
   Sripo, Thanya
   Roongpraiwan, Rawiwan
   Hansakunachai, Tippawan
   Wirojanan, Juthamas
   Sombuntham, Tasnawat
   Ruangdaraganon, Nichara
   Limprasert, Pornprot
TI Mutation Screening of the Neurexin 1 Gene in Thai Patients with
   Intellectual Disability and Autism Spectrum Disorder
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
ID STRUCTURAL VARIANTS; MENTAL-RETARDATION; INDIVIDUALS; DELETIONS; NRXN1;
   ADHESION; NLGN3
AB Aim: Neurexin 1 has two major protein isoforms using alternative promoters, coding for the alpha-neurexin 1 (alpha-NRXN1) and beta-neurexin 1 (beta-NRXN1) genes. This study is to explore the possibility that variants of the NRXN1 gene predispose to intellectual disability (ID) and autism spectrum disorder (ASD). Methods: The coding regions in 24 exons and exon-intron boundaries of the NRXN1 gene were investigated in 115 Thai patients with ID and ASD by direct DNA sequencing. Results: Nine novel variants of the NRXN1 gene were identified. Four novel variants were found in the beta-NRXN1 gene, one variant of six GGC repeats in exon 1, and three variants at the 5'UTR. Five novel variants were identified in the alpha-NRXN1 gene, four intronic variants and one missense variant in exon 14 (c.2713T > A or p.F905I). Conclusion: Mutation screening of the NRXN1gene in patients with ID and ASD may be useful to identify potential variants predisposing to ID and ASD. However, further studies utilizing protein functional analysis of the novel variants are required for a more definite conclusion.
C1 [Yangngam, Supaporn] Prince Songkla Univ, Fac Med, Grad Program Biomed Sci, Hat Yai 90110, Songkhla, Thailand.
   [Yangngam, Supaporn] Prince Songkla Univ, Fac Med Technol, Hat Yai 90110, Songkhla, Thailand.
   [Plong-On, Oradawan; Sripo, Thanya; Limprasert, Pornprot] Prince Songkla Univ, Fac Med, Div Human Genet, Dept Pathol, Hat Yai 90110, Songkhla, Thailand.
   [Roongpraiwan, Rawiwan; Sombuntham, Tasnawat; Ruangdaraganon, Nichara] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pediat, Bangkok 10400, Thailand.
   [Hansakunachai, Tippawan] Thammasat Univ, Dept Pediat, Fac Med, Pathum Thani, Thailand.
   [Wirojanan, Juthamas] Prince Songkla Univ, Fac Med, Dept Pediat, Hat Yai 90110, Songkhla, Thailand.
RP Limprasert, P (reprint author), Prince Songkla Univ, Fac Med, Div Human Genet, Dept Pathol, Hat Yai 90110, Songkhla, Thailand.
EM lpornpro@yahoo.com
FU National Center for Genetic Engineering and Biotechnology (BIOTEC)
   [BT-B-01-MG-18-4814]; Faculty of Medicine [48/364-006, 48/364-006-1,
   48/364-006-2]; Prince of Songkla University [MED5202355, MED5406475]
FX This study was supported by the National Center for Genetic Engineering
   and Biotechnology (BIOTEC) grant no. BT-B-01-MG-18-4814, and co-research
   funding between the Faculty of Medicine (48/364-006, 48/364-006-1 and
   48/364-006-2) and Prince of Songkla University (MED5202355 and
   MED5406475).
CR Bena F, 2013, AM J MED GENET B, V162B, P388, DOI 10.1002/ajmg.b.32148
   Camacho-Garcia RJ, 2012, NEUROBIOL DIS, V47, P135, DOI 10.1016/j.nbd.2012.03.031
   Comoletti D, 2010, STRUCTURE, V18, P1044, DOI 10.1016/j.str.2010.06.005
   Dabell MP, 2013, AM J MED GENET A, V161A, P717, DOI 10.1002/ajmg.a.35780
   Ding DC, 2005, PROSTATE, V62, P133, DOI 10.1002/pros.20128
   Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
   Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
   Liu Y, 2012, INT J NONLIN SCI NUM, V13, P1
   Mikhailov A, 2014, PSYCHIAT GENET, V24, P42, DOI 10.1097/YPG.0000000000000019
   Miles JH, 2010, GENEREVIEWS
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Miller MT, 2011, STRUCTURE, V19, P767, DOI 10.1016/j.str.2011.03.011
   Rowen L, 2002, GENOMICS, V79, P587, DOI 10.1006/geno.2002.6734
   Schaaf CP, 2012, EUR J HUM GENET, V20, P1240, DOI 10.1038/ejhg.2012.95
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Tabuchi K, 2002, GENOMICS, V79, P849, DOI 10.1006/geno.2002.6780
   Yan J, 2008, NEUROSCI LETT, V438, P368, DOI 10.1016/j.neulet.2008.04.074
   Ye HH, 2010, NEUROSIGNALS, V18, P62, DOI 10.1159/000322543
   Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 22
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
EI 1945-0257
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD JUL
PY 2014
VL 18
IS 7
BP 510
EP 515
DI 10.1089/gtmb.2014.0003
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AL8MG
UT WOS:000339392600010
PM 24832020
ER

PT J
AU Chan, DFY
   Chan, SHY
   So, HK
   Li, AM
   Ng, RCM
   Tsang, N
AF Chan, D. F. Y.
   Chan, S. H. Y.
   So, H. K.
   Li, A. M.
   Ng, R. C. M.
   Tsang, N.
TI Dental Health of Preschool Children with Autism Spectrum Disorder in
   Hong Kong
SO HONG KONG JOURNAL OF PAEDIATRICS
LA English
DT Article
DE Austism spectrum disorder; Dental health; Preschool children
ID CARIES EXPERIENCE; CARE NEEDS; PROGRAM
AB Children with autism spectrum disorder (ASD) were reported to have higher rates of unmet dental needs and behavioural problems that leading to dental care or oral hygiene problems. With the lack of dental services for preschool children in Hong Kong, the severity of dental problems in this group of children has not been documented locally. The aim of this study is to evaluate how well the preschool aged children with autism spectrum disorder comply with the recommendations from the dental profession, namely of tooth brushing habits, dental visits and rate of dental caries. Seventy percent of the 196 recruited children diagnosed with ASD with a mean age of 5.36 years from thirteen rehabilitation centres had established a twice daily tooth brushing habit at a mean age of 2.5 years. Eight-three of the children reported to have behavioural problems during toothbrushing. Thirty-six percent of these behavioural problems were unrelated to the toothbrushing procedure, including crying, screaming and other aggressive behaviour. Twenty-six percent suffered from dental caries of which 60% were reported as severe. Only 48% of them had visited dental services, the majority of these attending for dental checkups. Dental caries was significant higher in mother with low educational level and low-income families with children of ASD. Dental problems in this group of children are not a minor issue. A primary screening dental checkup service for preschool children with ASD especially in low-income families should be deeply considered in Hong Kong.
C1 [Chan, D. F. Y.; Chan, S. H. Y.; So, H. K.; Li, A. M.] Chinese Univ Hong Kong, Fac Med, Dept Paediat, Shatin, Hong Kong, Peoples R China.
   [Ng, R. C. M.; Tsang, N.] Heep Hong Soc, Hong Kong, Hong Kong, Peoples R China.
RP Chan, DFY (reprint author), Chinese Univ Hong Kong, Fac Med, Dept Paediat, Shatin, Hong Kong, Peoples R China.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   [Anonymous], 2001, OR HLTH SURV 2001 RE
   Carvalho TS, 2012, BRAZ ORAL RES, V26, P557, DOI 10.1590/S1806-83242012000600012
   Jaber MA, 2011, J APPL ORAL SCI, V19, P212, DOI 10.1590/S1678-77572011000300006
   Jokela J, 2003, ACTA ODONTOL SCAND, V61, P110, DOI 10.1080/00016350310002450
   Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
   Kopycka-Kedzierawski DT, 2008, PEDIATR DENT, V30, P54
   Kuhaneck Heather Miller, 2012, Spec Care Dentist, V32, P229, DOI 10.1111/j.1754-4505.2012.00283.x
   Lai BE, 2012, J AUTISM DEV DISORD, V42, P1294, DOI 10.1007/s10803-011-1362-2
   Locker D, 2004, J PUBLIC HEALTH DENT, V64, P63, DOI 10.1111/j.1752-7325.2004.tb02729.x
   Loo CY, 2008, J AM DENT ASSOC, V139, P1518
   Marshall J, 2007, PEDIATR DENT, V29, P369
   Morinushi Takanobu, 2001, J CLIN PEDIATR DENT, V25, P323
   NCBDDD, 2012, CDC DAT STAT AUT SPE
   Nelson LP, 2011, PEDIATR DENT, V33, P29
   Orellana LM, 2012, MED ORAL PATOL ORAL, V17, pE415, DOI 10.4317/medoral.17573
   Scottish Intercollegiate Guidelines Network (SIGN), 2005, PREV MAN DENT DEC PR
   U.S. National Institutes of Health National Institute of Dental and Craniofacial Research, PRACT OR CAR PEOPL A
   Wong VCN, 2008, J CHILD NEUROL, V23, P67, DOI 10.1177/0883073807308702
   Woo EKF, 2007, 3 CASER
NR 20
TC 0
Z9 0
PU MEDCOM LTD
PI CHAI WAN
PA ROOM 504-5, CHEUNG TAT CENTRE, 18 CHEUNG LEE ST, CHAI WAN, HONG KONG
   00000, PEOPLES R CHINA
SN 1013-9923
J9 HONG KONG J PAEDIATR
JI Hong Kong J. Paediatr.
PD JUL
PY 2014
VL 19
IS 3
BP 161
EP 168
PG 8
WC Pediatrics
SC Pediatrics
GA AL8UJ
UT WOS:000339414900004
ER

PT J
AU Yang, WZ
   Zhao, YJ
AF Yang, W. Z.
   Zhao, Y. J.
TI Clinical Report: A Female with Down Syndrome and Autism
SO HONG KONG JOURNAL OF PAEDIATRICS
LA English
DT Article
DE Autism; Comorbidity; Down syndrome
ID DISORDERS
AB Objective: The association of autism and Down syndrome (DS) is comparatively uncommon, especially in females. We report a female patient with both DS and autism with detailed clinical information. Methods: The diagnosis of DS based on a particular set of facial characteristics, delayed growth and chromosomal analysis. Autism Behavior Checklist and the DSM-IV criteria of autism were used for the diagnosis of autism. Case presentation: A five-year-old girl was sent to our department due to unusual social development, language delay and restricted behaviour. At 8 months, she was diagnosed to have DS with the karyotype of 47, XX, +21. Autism was diagnosed based on the behaviour and the DSM-IV criteria. On the modified ABC, the score given by her mother was 90, which further supported the diagnosis. Conclusion: With low index of suspicion, autism/autism spectrum disorders can easily be missed in patients with DS. Increase in awareness that the 2 conditions can coexist in the same patient is important to paediatricians.
C1 [Yang, W. Z.; Zhao, Y. J.] China Med Univ, Shengjing Hosp, Dept Dev Pediat, Shenyang 110004, Peoples R China.
RP Zhao, YJ (reprint author), China Med Univ, Shengjing Hosp, Dept Dev Pediat, 36 Sanhao St, Shenyang 110004, Peoples R China.
FU National Natural Science Foundation of China [81101019]
FX This study was supported by a grant from the National Natural Science
   Foundation of China (no. 81101019). Special thanks to the patient and
   her guardian for their support and participation.
CR Carter JC, 2007, AM J MED GENET B, V144B, P87, DOI 10.1002/ajmg.b.30407
   Dykens EM, 2007, MENT RETARD DEV D R, V13, P272, DOI 10.1002/mrdd.20159
   Guo R., 2004, CHIN J CLIN REHABIL, V8, P1122
   Hussman JP, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-1
   Makino T, 2010, P NATL ACAD SCI USA, V107, P9270, DOI 10.1073/pnas.0914697107
   WAKABAYASHI S, 1979, J AUTISM DEV DISORD, V9, P31, DOI 10.1007/BF01531289
   Winther M, 2012, INT J BIOCHEM CELL B, V44, P441, DOI 10.1016/j.biocel.2011.11.020
   Zhang ZX, 1996, CHIN J CLIN PSYCHOL, V4, P129
NR 8
TC 0
Z9 0
PU MEDCOM LTD
PI CHAI WAN
PA ROOM 504-5, CHEUNG TAT CENTRE, 18 CHEUNG LEE ST, CHAI WAN, HONG KONG
   00000, PEOPLES R CHINA
SN 1013-9923
J9 HONG KONG J PAEDIATR
JI Hong Kong J. Paediatr.
PD JUL
PY 2014
VL 19
IS 3
BP 185
EP 187
PG 3
WC Pediatrics
SC Pediatrics
GA AL8UJ
UT WOS:000339414900008
ER

PT J
AU Fishman, I
   Keown, CL
   Lincoln, AJ
   Pineda, JA
   Muller, RA
AF Fishman, Irina
   Keown, Christopher L.
   Lincoln, Alan J.
   Pineda, Jaime A.
   Mueller, Ralph-Axel
TI Atypical Cross Talk Between Mentalizing and Mirror Neuron Networks in
   Autism Spectrum Disorder
SO JAMA PSYCHIATRY
LA English
DT Article
ID INTRINSIC FUNCTIONAL CONNECTIVITY; RESTING HUMAN BRAIN; STRUCTURAL
   CONNECTIVITY; ASPERGER-SYNDROME; MIND; IMITATION; CHILDREN; ACTIVATION;
   MECHANISMS; DEFICITS
AB IMPORTANCE Converging evidence indicates that brain abnormalities in autism spectrum disorder (ASD) involve atypical network connectivity, but it is unclear whether altered connectivity is especially prominent in brain networks that participate in social cognition.
   OBJECTIVE To investigate whether adolescents with ASD show altered functional connectivity in 2 brain networks putatively impaired in ASD and involved in social processing, theory of mind (ToM) and mirror neuron system (MNS).
   DESIGN, SETTING, AND PARTICIPANTS Cross-sectional study using resting-state functional magnetic resonance imaging involving 25 adolescents with ASD between the ages of 11 and 18 years and 25 typically developing adolescents matched for age, handedness, and nonverbal IQ.
   MAIN OUTCOMES AND MEASURES Statistical parametric maps testing the degree of whole-brain functional connectivity and social functioning measures.
   RESULTS Relative to typically developing controls, participants with ASD showed a mixed pattern of both over- and underconnectivity in the ToM network, which was associated with greater social impairment. Increased connectivity in the ASD group was detected primarily between the regions of the MNS and ToM, and was correlated with sociocommunicative measures, suggesting that excessive ToM-MNS cross talk might be associated with social impairment. In a secondary analysis comparing a subset of the 15 participants with ASD with the most severe symptomology and a tightly matched subset of 15 typically developing controls, participants with ASD showed exclusive overconnectivity effects in both ToM and MNS networks, which were also associated with greater social dysfunction.
   CONCLUSIONS AND RELEVANCE Adolescents with ASD showed atypically increased functional connectivity involving the mentalizing and mirror neuron systems, largely reflecting greater cross talk between the 2. This finding is consistent with emerging evidence of reduced network segregation in ASD and challenges the prevailing theory of general long-distance underconnectivity in ASD. This excess ToM-MNS connectivity may reflect immature or aberrant developmental processes in 2 brain networks involved in understanding of others, a domain of impairment in ASD. Further, robust links with sociocommunicative symptoms of ASD implicate atypically increased ToM-MNS connectivity in social deficits observed in ASD.
C1 [Fishman, Irina; Keown, Christopher L.; Mueller, Ralph-Axel] San Diego State Univ, San Diego, CA 92120 USA.
   [Lincoln, Alan J.] Alliant Int Univ, San Diego, CA USA.
   [Pineda, Jaime A.] Univ Calif San Diego, La Jolla, CA 92093 USA.
RP Fishman, I (reprint author), San Diego State Univ, Brain Dev Imaging Lab, Dept Psychol, 6363 Alvarado Ct,Ste 200, San Diego, CA 92120 USA.
EM ifishman@mail.sdsu.edu
FU National Institutes of Health [R01 MH081023, K01 MH097972]; Autism
   Science Foundation [12-1001]; Congressionally Directed Medical Research
   Programs grant [AR093335]
FX This work was supported by grants from the National Institutes of Health
   (grants R01 MH081023 to Dr Muller and K01 MH097972 to Dr Fishman) and
   the Autism Science Foundation (grant 12-1001 to Dr Fishman). Data
   acquisition in 7 participants was funded by a Congressionally Directed
   Medical Research Programs grant (grant AR093335 to Dr Pineda).
CR Allen Elena A, 2011, Front Syst Neurosci, V5, P2, DOI 10.3389/fnsys.2011.00002
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Beckmann CF, 2005, PHILOS T ROY SOC B, V360, P1001, DOI 10.1098/rstb.2005.1634
   Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Cordes D, 2001, AM J NEURORADIOL, V22, P1326
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Cox RW, 1996, COMPUT BIOMED RES, V29, P162, DOI 10.1006/cbmr.1996.0014
   Damoiseaux JS, 2006, P NATL ACAD SCI USA, V103, P13848, DOI 10.1073/pnas.0601417103
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Dinstein I, 2010, NEURON, V66, P461, DOI 10.1016/j.neuron.2010.03.034
   Dosenbach NUF, 2010, SCIENCE, V329, P1358, DOI 10.1126/science.1194144
   Fair DA, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000381
   Fair DA, 2007, P NATL ACAD SCI USA, V104, P13507, DOI 10.1073/pnas.0705843104
   FORMAN SD, 1995, MAGNET RESON MED, V33, P636, DOI 10.1002/mrm.1910330508
   Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
   Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
   Greicius MD, 2009, CEREB CORTEX, V19, P72, DOI 10.1093/cercor/bhn059
   Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Hasson U, 2009, P NATL ACAD SCI USA, V106, P10841, DOI 10.1073/pnas.0903253106
   Honey CJ, 2009, P NATL ACAD SCI USA, V106, P2035, DOI 10.1073/pnas.0811168106
   Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
   Kaland N, 2002, J CHILD PSYCHOL PSYC, V43, P517, DOI 10.1111/1469-7610.00042
   Kana RK, 2009, SOC NEUROSCI, V4, P135
   Kennedy DP, 2008, SOC COGN AFFECT NEUR, V3, P177, DOI 10.1093/scan/nsn011
   Lewisa CM, 2009, P NATL ACAD SCI USA, V106, P17558, DOI 10.1073/pnas.0902455106
   Lombardo MV, 2011, NEUROIMAGE, V56, P1832, DOI 10.1016/j.neuroimage.2011.02.067
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Muller RA, 2007, MENT RETARD DEV D R, V13, P85, DOI 10.1002/mrdd.20141
   Nebel MB, 2012, HUM BRAIN MAPP
   Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Rizzolatti G, 1996, COGNITIVE BRAIN RES, V3, P131, DOI 10.1016/0926-6410(95)00038-0
   Rizzolatti G, 2010, EXP BRAIN RES, V200, P223, DOI 10.1007/s00221-009-2002-3
   Rudie J D, 2012, Neuroimage Clin, V2, P79, DOI 10.1016/j.nicl.2012.11.006
   Rudie JD, 2012, CEREB CORTEX, V22, P1025, DOI 10.1093/cercor/bhr171
   Rutter M, 2003, AUSTIM DIAGNOSTIC IN
   Schipul Sarah E, 2011, Front Syst Neurosci, V5, P10, DOI 10.3389/fnsys.2011.00010
   Shehzad Z, 2009, CEREB CORTEX, V19, P2209, DOI 10.1093/cercor/bhn256
   Shih P, 2011, BIOL PSYCHIAT, V70, P270, DOI 10.1016/j.biopsych.2011.03.040
   Sigman M, 2004, MENT RETARD DEV D R, V10, P221, DOI 10.1002/mrdd.20046
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Simmons WK, 2012, SOC COGN AFFECT NEUR, V7, P467, DOI 10.1093/scan/nsr018
   Smith SM, 2009, P NATL ACAD SCI USA, V106, P13040, DOI 10.1073/pnas.0905267106
   Spengler S, 2010, BIOL PSYCHIAT, V68, P1148, DOI 10.1016/j.biopsych.2010.09.017
   Stevens WD, 2010, CEREB CORTEX, V20, P1997, DOI 10.1093/cercor/bhp270
   Supekar K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000157
   Tager-Flusberg H, 2010, NEURAL NETWORKS, V23, P1072, DOI 10.1016/j.neunet.2010.07.008
   Tager-Flusberg H, 2007, CURR DIR PSYCHOL SCI, V16, P311, DOI 10.1111/j.1467-8721.2007.00527.x
   Talairach J., 1988, COPLANAR STEREOTACTI
   Van Dijk KRA, 2010, J NEUROPHYSIOL, V103, P297, DOI 10.1152/jn.00783.2009
   Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
   Van Overwalle F, 2009, NEUROIMAGE, V48, P564, DOI 10.1016/j.neuroimage.2009.06.009
   Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
   Wang AT, 2007, ARCH GEN PSYCHIAT, V64, P698, DOI 10.1001/archpsyc.64.6.698
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   Zuo XN, 2010, NEUROIMAGE, V49, P1432, DOI 10.1016/j.neuroimage.2009.09.037
NR 72
TC 3
Z9 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JUL
PY 2014
VL 71
IS 7
BP 751
EP 760
DI 10.1001/jamapsychiatry.2014.83
PG 10
WC Psychiatry
SC Psychiatry
GA AL5HU
UT WOS:000339165200005
PM 24740586
ER

PT J
AU Klitzman, R
   Abbate, KJ
   Chung, WK
   Ottman, R
   Leu, CS
   Appelbaum, PS
AF Klitzman, Robert
   Abbate, Kristopher J.
   Chung, Wendy K.
   Ottman, Ruth
   Leu, Cheng-Shiun
   Appelbaum, Paul S.
TI Views of Preimplantation Genetic Diagnosis Among Psychiatrists and
   Neurologists
SO JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article
DE assisted reproductive technology; doctor-patient communication; ethics;
   eugenics; gender selection; obstetrics/gynecology; preimplantation
   genetic diagnosis; prenatal genetic testing
ID ATTITUDES; PHYSICIANS; RATES; CHINA; PGD
AB OBJECTIVE: To examine key aspects of neurologists' and psychiatrists' views and approaches regarding prenatal genetic testing (GT) and preimplantation genetic diagnosis (PGD).
   STUDY DESIGN: We surveyed attitudes and practices among 163 neurologists and 372 psychiatrists.
   RESULTS: A total of 24.9% of neurologists and 31.9% of psychiatrists had discussed prenatal GT with patients, but 95.3% did not feel comfortable discussing PGD; only 2.9% discussed it, and only 1.8% had patients ask about PGD. Most would refer for PGD for Huntington's disease and Tay-Sachs disease, fewer for cystic fibrosis, and fewer still for autism, Alzheimer's disease, or gender selection for family balancing; in each of these cases, psychiatrists' percentages were higher than those of neurologists. Providers who would refer for PGD for Huntington's disease, cystic fibrosis, or gender selection differed from others in proportions of patients with insurance and were more likely to have undergone a GT themselves and be concerned about discrimination.
   CONCLUSION: These data, the first to examine how neurologists and psychiatrists view PGD, suggest that they do not feel comfortable discussing PGD but have strong views about its use. Potential PGD use is associated with concerns about discrimination and less experience with GT. These data highlight the need for enhancing education about these technologies among various providers.
C1 Columbia Univ, Med Ctr, Dept Clin Psychiat, New York, NY 10032 USA.
   Columbia Univ, Med Ctr, Dept Epidemiol, New York, NY 10032 USA.
   Columbia Univ, Med Ctr, Dept Neurol, New York, NY 10032 USA.
   Columbia Univ, Med Ctr, HIV Ctr Clin & Behav Studies, New York, NY 10032 USA.
   New York State Psychiat Inst & Hosp, Gertrude H Sergievsky Ctr, New York, NY 10032 USA.
   New York State Psychiat Inst & Hosp, Div Epidemiol, New York, NY 10032 USA.
RP Klitzman, R (reprint author), Columbia Univ, Dept Clin Psychiat, 1051 Riverside Dr,Unit 15, New York, NY 10032 USA.
EM rlk2@columbia.edu
RI Ottman, Ruth/O-2371-2013
FU National Human Genome Research Institute [1P20HG005535-01,
   1P50HG007257-01]
FX This work was supported by National Human Genome Research Institute
   grants #1P20HG005535-01 and #1P50HG007257-01 (Paul Appelbaum, Principal
   Investigator).
CR ACOG Committee on Genetics, 2009, OBSTET GYNECOL, V113, P1194
   Asch S, 2000, J GEN INTERN MED, V15, P591, DOI 10.1046/j.1525-1497.2000.02329.x
   Baruch S, 2006, FERTIL STERIL, V89, P1
   Brandt AC, 2010, FAM CANCER, V9, P479, DOI 10.1007/s10689-010-9343-8
   Chan CLW, 2002, J ASSIST REPROD GEN, V19, P426, DOI 10.1023/A:1016815807703
   Cull WL, 2005, HEALTH SERV RES, V40, P213, DOI 10.1111/j.1475-6773.2005.00350.x
   Das Gupta M, 2003, J DEV STUD, V40, P153, DOI 10.1080/00220380412331293807
   Demko ZP, 2010, J C EMBRYOLOGY, V13, P6
   Amato P, 2013, FERTIL STERIL, V100, P54, DOI 10.1016/j.fertnstert.2013.02.043
   Galea S, 2007, ANN EPIDEMIOL, V17, P643, DOI 10.1016/j.annepidem.2007.03.013
   GUADAGNOLI E, 1989, EVAL HEALTH PROF, V12, P318, DOI 10.1177/016327878901200306
   Hovland E J, 1980, J Dent Educ, V44, P270
   Hudson KL, 2006, FERTIL STERIL, V85, P1638, DOI 10.1016/j.fertnstert.2006.01.014
   Human Fertilisation and Embryology Authority, 2013, PGD COND LIC HFEA
   Kellerman SE, 2001, AM J PREV MED, V20, P61, DOI 10.1016/S0749-3797(00)00258-0
   Klitzman R, 2013, REPROD BIOMED ONLINE, V26, P142, DOI 10.1016/j.rbmo.2012.11.006
   Kokkali G, 2007, HUM REPROD, V22, P1443, DOI 10.1093/humrep/del506
   Melnyk SA, 2012, J PURCH SUPPLY MANAG, V18, P35, DOI 10.1016/j.pursup.2011.12.002
   Ogilvie CM, 2005, J HISTOCHEM CYTOCHEM, V53, P255, DOI 10.1369/jhc.4B6395.2005
   Traeger-Synodinos J, 2013, INT J LAB HEMATOL, V35, P571, DOI 10.1111/ijlh.12086
   Traeger-Synodinos J, 2013, HUM REPROD, V28, P18
NR 21
TC 0
Z9 0
PU SCI PRINTERS & PUBL INC
PI ST LOUIS
PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA
SN 0024-7758
EI 1943-3565
J9 J REPROD MED
JI J. Reprod. Med.
PD JUL-AUG
PY 2014
VL 59
IS 7-8
BP 385
EP 392
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AL8UG
UT WOS:000339414600008
PM 25098029
ER

PT J
AU Wolff, ER
   Madlon-Kay, DJ
AF Wolff, Emily R.
   Madlon-Kay, Diane J.
TI Childhood Vaccine Beliefs Reported by Somali and Non-Somali Parents
SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
LA English
DT Article
DE Autism; Measles; Somalia; Vaccination; Immunization
ID MEASLES
AB Background: In 2011, an outbreak of measles in Minnesota was traced back to an unvaccinated Somali child. The purpose of this project was to (1) ascertain whether Somali parents are more likely than non-Somalis to refuse childhood vaccinations, particularly the measles-mumps-rubella (MMR) vaccine and (2) determine what factors influence the decision not to vaccinate.
   Methods: We explored parental perceptions and utilization of vaccines through a survey distributed to a convenience sample of Somali and non-Somali parents of children <= 5 years old in a family medicine clinic in Minneapolis, MN.
   Results: A total of 99 surveys were completed, 28% (n = 27) by Somali parents. Somali parents were more likely than non-Somali parents to have refused the MMR vaccine for their child (odds ratio, 4.6; 95% confidence interval, 1.2-18.0). Most of them refused vaccines because they had heard of adverse effects associated with the vaccine or personally knew someone who suffered an adverse effect. Somali parents were significantly more likely to believe that autism is caused by vaccines (35% vs. 8% of non-Somali parents). Somalis were also more likely to be uncomfortable with administering multiple vaccines at one visit (odds ratio, 4.0; 95% confidence interval, 1.4-11.9) and more likely to believe that children receive too many vaccines.
   Conclusions: Statistically significant differences in perceptions and use of vaccines were reported by Somali and non-Somali participants. Somali parents are more likely to believe that the MMR vaccine causes autism and more likely to refuse the MMR vaccine than non-Somali parents. These beliefs have contributed to an immunization gap between Somali and non-Somali children.
C1 [Madlon-Kay, Diane J.] Univ Minnesota, Dept Family Med & Community Hlth, Sch Med, Minneapolis, MN 55455 USA.
RP Wolff, ER (reprint author), Univ Minnesota, Med Sch Twin Cities, 420 Delaware St SE, Minneapolis, MN 55455 USA.
EM smit6761@umn.edu
FU David Mercy Summer Externship Program of the Minnesota Academy of Family
   Physicians Foundation; Minnesota Academy of Family Physicians; American
   Academy of Family Physicians
FX Funding: The study was funded by the David Mercy Summer Externship
   Program of the Minnesota Academy of Family Physicians Foundation, The
   Minnesota Academy of Family Physicians, and the American Academy of
   Family Physicians.
CR Lynfield R., 2011, Morbidity and Mortality Weekly Report, V60, P421
   McLean Huong, 2012, Morbidity and Mortality Weekly Report, V61, P253
   Hewitt A, 2013, MINNEAPOLIS SOMALI A
   Kennedy A, 2011, PEDIATRICS, V127, pS92, DOI 10.1542/peds.2010-1722N
   Kulane A, 2007, SOMALI PARENTS ACCEP
   Minnesota Department of Health, AUT SOM COMM REP STU
   Poland GA, 2011, MAYO CLIN PROC, V86, P869, DOI 10.4065/mcp.2011.0467
   Rubin R, 2011, WHATS LATEST MEASLES
   Sabella C, 2010, CLEV CLIN J MED, V77, P207, DOI 10.3949/ccjm.77a.09123
   Tomlinson N, 2013, DIVERS EQUAL HLTH CA, V10, P101
NR 10
TC 1
Z9 1
PU AMER BOARD FAMILY MEDICINE
PI LEXINGTON
PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA
SN 1557-2625
EI 1558-7118
J9 J AM BOARD FAM MED
JI J. Am. Board Fam. Med.
PD JUL-AUG
PY 2014
VL 27
IS 4
BP 458
EP 464
DI 10.3122/jabfm.2014.04.130275
PG 7
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AL5IS
UT WOS:000339167800009
PM 25002000
ER

PT J
AU Varella, AAB
   de Souza, DG
AF Varella, Andre A. B.
   de Souza, Deisy G.
TI EMERGENCE OF AUDITORY-VISUAL RELATIONS FROM A VISUAL-VISUAL BASELINE
   WITH AUDITORY-SPECIFIC CONSEQUENCES IN INDIVIDUALS WITH AUTISM
SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
LA English
DT Article
DE equivalence relations; outcome specific reinforcement; conditional
   discrimination; auditory-visual discrimination; autism
ID MATCHING-TO-SAMPLE; STIMULUS-REINFORCER RELATIONS;
   EQUIVALENCE-RELATIONS; CONDITIONAL DISCRIMINATION; DIFFERENTIAL
   OUTCOMES; TRAINING PROCEDURE; SYMBOLIC BEHAVIOR; CLASS MEMBERSHIP;
   CHILDREN; ADULTS
AB Empirical studies have demonstrated that class-specific contingencies may engender stimulus-reinforcer relations. In these studies, crossmodal relations emerged when crossmodal relations comprised the baseline, and intramodal relations emerged when intramodal relations were taught during baseline. This study investigated whether auditory-visual relations (crossmodal) would emerge after participants learned a visual-visual baseline (intramodal) with auditory stimuli presented as specific consequences. Four individuals with autism learned AB and CD relations with class-specific reinforcers. When A1 and C1 were presented as samples, the selections of B1 and D1, respectively, were followed by an edible (R1) and a sound (S1). Selections of B2 and D2 under the control of A2 and C2, respectively, were followed by R2 and S2. Probe trials tested for visual-visual AC, CA, AD, DA, BC, CB, BD, and DB emergent relations and auditory-visual SA, SB, SC, and SD emergent relations. All of the participants demonstrated the emergence of all auditory-visual relations, and three of four participants showed emergence of all visual-visual relations. Thus, the emergence of auditory-visual relations from specific auditory consequences suggests that these relations do not depend on crossmodal baseline training. The procedure has great potential for applied technology to generate auditory-visual discriminations and stimulus classes in the context of behavior-analytic interventions for autism.
C1 [Varella, Andre A. B.; de Souza, Deisy G.] Univ Fed Sao Carlos, BR-13565905 Sao Carlos, SP, Brazil.
RP Varella, AAB (reprint author), Univ Fed Sao Carlos, Lab Estudos Comportamento Humano, Rodovia Washington Luis,Km 235, BR-13565905 Sao Carlos, SP, Brazil.
EM andreavarella@gmail.com; ddgs@ufscar.br
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2009/011-003]; CNPq [573972/2008-7]; FAPESP [08/57705-8]
FX This research was supported by Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP; Doctoral scholarship #2009/011-003 to the first
   author). This report is based on a doctoral dissertation submitted by
   the first author to the Graduate Program in Psychology, Universidade
   Federal de Sao Carlos. The study was part of the research program of
   Instituto Nacional de Ciencia e Tecnologia sobre Comportamento, Cognicao
   e Ensino, supported by grants from CNPq (Grant # 573972/2008-7) and
   FAPESP (Grant # 08/57705-8).
CR Barros R. S., 2006, BRAZILIAN J BEHAV AN, V2, P79
   Carp CL, 2012, J APPL BEHAV ANAL, V45, P737, DOI 10.1901/jaba.2012.45-737
   CARRIGAN PF, 1992, J EXP ANAL BEHAV, V58, P183, DOI 10.1901/jeab.1992.58-183
   Clark KM, 2004, J APPL BEHAV ANAL, V37, P503, DOI 10.1901/jaba.2004.37-503
   Davison M, 1999, J EXP ANAL BEHAV, V71, P439, DOI 10.1901/jeab.1999.71-439
   DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
   DIXON LS, 1977, J EXP ANAL BEHAV, V27, P433, DOI 10.1901/jeab.1977.27-433
   Dube W. V., 1991, EXPT ANAL HUMAN BEHA, V9, P28
   DUBE WV, 1987, J EXP ANAL BEHAV, V47, P159, DOI 10.1901/jeab.1987.47-159
   Dube WV, 1998, RES DEV DISABIL, V19, P347, DOI 10.1016/S0891-4222(98)00009-2
   DUBE WV, 1989, J EXP ANAL BEHAV, V51, P65, DOI 10.1901/jeab.1989.51-65
   DUBE WV, 1995, PSYCHOL REC, V45, P591
   Dunn L. M., 1981, PEABODY PICTURE VOCA
   Fienup D. M., 2006, EUROPEAN J BEHAV ANA, V7, P87
   Fisher WW, 2007, J APPL BEHAV ANAL, V40, P489, DOI 10.1901/jaba.2007.40-489
   Goyos A. C. N., 2000, PSYCHOL REC, V50, P629
   Green G., 2001, FOCUS AUTISM OTHER D, V16, P72, DOI 10.1177/108835760101600203
   GREEN G, 1990, AM J MENT RETARD, V95, P260
   Grow LL, 2011, J APPL BEHAV ANAL, V44, P475, DOI 10.1901/jaba.2011.44-475
   HAYES LJ, 1988, PSYCHOL REC, V38, P473
   Horne PJ, 1996, J EXP ANAL BEHAV, V65, P185, DOI 10.1901/jeab.1996.65-185
   Johnson C, 2014, J EXP ANAL BEHAV, V101, P38, DOI 10.1002/jeab.61
   Joseph B, 1997, AM J MENT RETARD, V101, P374
   Kerr N., 1977, REHABIL PSYCHOL, V24, P95
   Leader G, 2000, PSYCHOL REC, V50, P63
   MCILVANE WJ, 1990, AM J MENT RETARD, V95, P283
   MCILVANE WJ, 1981, J MENT DEFIC RES, V25, P33
   Minster ST, 2006, J EXP ANAL BEHAV, V85, P371, DOI 10.1901/jeab.2006.15-05
   Mok LW, 2010, PSYCHOL REC, V60, P227
   Pilgrim C, 2011, ABAI 6 INT C GRAN SP
   Rehfeldt RA, 2005, BEHAV MODIF, V29, P696, DOI 10.1177/0145445503261048
   Rehfeldt RA, 2011, J APPL BEHAV ANAL, V44, P109, DOI 10.1901/jaba.2011.44-109
   Sakko G, 2004, AM J MENT RETARD, V109, P44, DOI 10.1352/0895-8017(2004)109<44:VNMAAW>2.0.CO;2
   SAUNDERS KJ, 1989, J EXP ANAL BEHAV, V52, P1, DOI 10.1901/jeab.1989.52-1
   SCHENK JJ, 1994, PSYCHOL REC, V44, P537
   SIDMAN M, 1986, ANAL INTERVEN DEVEL, V6, P1, DOI 10.1016/0270-4684(86)90003-0
   Sidman M, 2000, J EXP ANAL BEHAV, V74, P127, DOI 10.1901/jeab.2000.74-127
   Sidman M., 1994, EQUIVALENCE RELATION
   SIDMAN M, 1971, J SPEECH HEAR RES, V14, P5
   SIDMAN M, 1982, J EXP ANAL BEHAV, V37, P5, DOI 10.1901/jeab.1982.37-5
   Smeets PM, 2005, PSYCHOL REC, V55, P483
   Smeets PM, 1997, PSYCHOL REC, V47, P285
   Takahashi K, 2011, RES AUTISM SPECT DIS, V5, P547, DOI 10.1016/j.rasd.2010.06.021
   TRAPOLD MA, 1970, LEARN MOTIV, V1, P129, DOI 10.1016/0023-9690(70)90079-2
   Urcuioli PJ, 2005, LEARN BEHAV, V33, P1
   Ward R., 2000, J DEV DISABILITIES, V7, P142
   Wilkinson KM, 2001, DEV REV, V21, P355, DOI 10.1006/drev.2000.0526
   Williams G, 2005, J APPL BEHAV ANAL, V38, P555, DOI 10.1901/jaba.2005.65-04
NR 48
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5002
EI 1938-3711
J9 J EXP ANAL BEHAV
JI J. Exp. Anal. Behav.
PD JUL
PY 2014
VL 102
IS 1
BP 139
EP 149
DI 10.1002/jeab.93
PG 11
WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental
SC Psychology; Behavioral Sciences
GA AL5GU
UT WOS:000339162500008
PM 24965883
ER

PT J
AU Serret, S
   Hun, S
   Iakimova, G
   Lozada, J
   Anastassova, M
   Santos, A
   Vesperini, S
   Askenazy, F
AF Serret, Sylvie
   Hun, Stephanie
   Iakimova, Galina
   Lozada, Jose
   Anastassova, Margarita
   Santos, Andreia
   Vesperini, Stephanie
   Askenazy, Florence
TI Facing the challenge of teaching emotions to individuals with low- and
   high-functioning autism using a new Serious game: a pilot study
SO MOLECULAR AUTISM
LA English
DT Article
DE Serious game; High-functioning Autism; Low-functioning Autism; Social
   Skills Training; Emotion Recognition; Computer-based Intervention
ID SPECTRUM DISORDERS; ASPERGER-SYNDROME; VIRTUAL-REALITY; CHILDREN;
   RECOGNITION; FACES; SKILLS; CHILDHOOD; INTERVENTION; EXPRESSIONS
AB Background: It is widely accepted that emotion processing difficulties are involved in Autism Spectrum Conditions (ASC). An increasing number of studies have focused on the development of training programs and have shown promising results. However, most of these programs are appropriate for individuals with high-functioning ASC (HFA) but exclude individuals with low-functioning ASC (LFA). We have developed a computer-based game called JeStiMulE based on logical skills to teach emotions to individuals with ASC, independently of their age, intellectual, verbal and academic level.
   The aim of the present study was to verify the usability of JeStiMulE (which is its adaptability, effectiveness and efficiency) on a heterogeneous ASC group. We hypothesized that after JeStiMulE training, a performance improvement would be found in emotion recognition tasks.
   Methods: A heterogeneous group of thirty-three children and adolescents with ASC received two one-hour JeStiMulE sessions per week over four weeks. In order to verify the usability of JeStiMulE, game data were collected for each participant. Furthermore, all participants were presented before and after training with five emotion recognition tasks, two including pictures of game avatars (faces and gestures) and three including pictures of real-life characters (faces, gestures and social scenes).
   Results: Descriptive data showed suitable adaptability, effectiveness and efficiency of JeStiMulE. Results revealed a significant main effect of Session on avatars (ANOVA: F (1,32) = 98.48, P < .001) and on pictures of real-life characters (ANOVA: F (1,32) = 49.09, P < .001). A significant Session x Task x Emotion interaction was also found for avatars (ANOVA: F (6,192) = 2.84, P = .01). This triple interaction was close to significance for pictures of real-life characters (ANOVA: F (12,384) = 1.73, P = .057). Post-hoc analyses revealed that 30 out of 35 conditions found a significant increase after training.
   Conclusions: JeStiMulE appears to be a promising tool to teach emotion recognition not only to individuals with HFA but also those with LFA. JeStiMulE is thus based on ASC-specific skills, offering a model of logical processing of social information to compensate for difficulties with intuitive social processing.
C1 [Serret, Sylvie; Hun, Stephanie; Santos, Andreia; Vesperini, Stephanie] Univ Hosp CHU Lenval, Child & Adolescent Psychiat Dept, Autism Resources Ctr, Nice, France.
   [Iakimova, Galina] Univ Nice Sophia Antipolis, Anthropol & Cognit & Social Psychol Res Unit, LAPCOS, EA 7278, F-06189 Nice, France.
   [Lozada, Jose; Anastassova, Margarita] CEA LIST DIASI, Sensory & Ambient Interfaces Lab, Fontenay Aux Roses, France.
   [Askenazy, Florence] Univ Hosp CHU Lenval, Child & Adolescent Psychiat Dept, Nice, France.
RP Serret, S (reprint author), Univ Hosp CHU Lenval, Child & Adolescent Psychiat Dept, Autism Resources Ctr, Nice, France.
EM serret.s@pediatrie-chulenval-nice.fr
FU Monaco Against Autism (MONAA); ABA Apprendre Autrement; Collectif
   Handicap 06; CoBteK (Cognitive Behaviour Technology); French Ministry of
   Industry
FX We are grateful to all children, adolescents and their families for
   their participation in this study. We also thank our partners (Idees3
   com, HLP Technologies, Autism Resources Center Nice, Day-care Units for
   children and adolescents with autism ('La Caravelle', 'Les Coteaux
   d'Azur' and 'Les Noisetiers') for their participation in this study.
   Written informed consent was obtained from all participants and their
   families. The consent form is held by the corresponding author and is
   available for review by the Editor-in-Chief. We also acknowledge the
   following associations for their support: Monaco Against Autism (MONAA),
   ABA Apprendre Autrement, Collectif Handicap 06. We acknowledge the
   support provided by CoBteK (Cognitive Behaviour Technology). The study
   promoter was the Nice University Hospital (CHUN). The project was funded
   by the French Ministry of Industry. The funding body had no role in the
   study design, data collection, analyses, and data
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
   Andanson J, 2011, ARCH PEDIATRIE, V18, P589, DOI 10.1016/j.arcped.2011.02.019
   Baghdadli A, 2010, NEUROPSYCHIAT ENFAN, V58, P456
   Bailly K, 2013, JEMIME SERIOUS GAME
   Barnes KA, 2008, NEUROPSYCHOLOGY, V22, P563, DOI 10.1037/0894-4105.22.5.563
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P3567, DOI 10.1098/rstb.2009.0191
   Baron-Cohen S, 2006, PROG NEURO-PSYCHOPH, V30, P865, DOI 10.1016/j.pnpbp.2006.01.010
   Begeer S, 2008, DEV REV, V28, P342, DOI 10.1016/j.dr.2007.09.001
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Blattner M. M., 1989, Human-Computer Interaction, V4, DOI 10.1207/s15327051hci0401_1
   Bölte Sven, 2002, Int J Circumpolar Health, V61 Suppl 2, P61
   Bolte S, 2009, Z KINDER JUG-PSYCH, V37, P495, DOI 10.1024/1422-4917.37.6.495
   Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
   Brewster SA, 1994, PROVIDING A STRUCTUR
   Brown J, 2010, Q J EXP PSYCHOL, V63, P1789, DOI 10.1080/17470210903536910
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Da Fonseca D, 2009, RES AUTISM SPECT DIS, V3, P50, DOI 10.1016/j.rasd.2008.04.001
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   DUNLAP G, 1984, J EXP CHILD PSYCHOL, V37, P41, DOI 10.1016/0022-0965(84)90057-2
   Dunn J, 2003, SER AFFECTIVE SCI, P332
   Dunn W., 1999, THE SENSORY PROFILE
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Gibbs R, 2002, THE VERBAL COMMUNICA, P125
   Golan Ofer, 2010, J Autism Dev Disord, V40, P269, DOI 10.1007/s10803-009-0862-9
   Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
   Gregoire J, 2006, LEXAMEN CLINIQUE DE
   Grelotti DJ, 2005, NEUROPSYCHOLOGIA, V43, P373, DOI 10.1016/j.neuropsychologia.2004.06.015
   Gross TF, 2008, J AUTISM DEV DISORD, V38, P297, DOI 10.1007/s10803-007-0391-3
   Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
   Grynspan O, AUTISM IN PRESS
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Hopkins IM, 2011, J AUTISM DEV DISORD, V41, P1543, DOI 10.1007/s10803-011-1179-z
   Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
   Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
   Joseph RM, 2004, DEV PSYCHOPATHOL, V16, P137, DOI 10.1017/S095457940404444X
   Kandalaft MR, 2013, J AUTISM DEV DISORD, V43, P34, DOI 10.1007/s10803-012-1544-6
   Kourkoulou A, 2012, J AUTISM DEV DISORD, V42, P244, DOI 10.1007/s10803-011-1237-6
   Langner O, 2010, COGNITION EMOTION, V24, P1377, DOI 10.1080/02699930903485076
   Lecocq P, 1996, EPREUVE DE COMPREHEN
   Lefavrais P, 1965, REV PSYCHOL APPL, V15, P33
   Lord C., 2000, AUTISM DIAGNOSTIC OB
   Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006
   Mitchell P, 2007, J AUTISM DEV DISORD, V37, P589, DOI 10.1007/s10803-006-0189-8
   Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x
   Nemeth D, LEARNING IN AUTISM I
   Nielsen J., 1994, USABILITY INSPECTION
   Parsons S, 2002, J INTELL DISABIL RES, V46, P430, DOI 10.1046/j.1365-2788.2002.00425.x
   Plutchik R, 1980, THEORY RESEARCH AND, V1
   Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
   Rosset D, 2011, RES AUTISM SPECT DIS, V5, P949, DOI 10.1016/j.rasd.2010.11.005
   Rosset DB, 2008, J AUTISM DEV DISORD, V38, P919, DOI 10.1007/s10803-007-0465-2
   Rutter M, 2003, ADI R THE AUTISM DIA
   Santos A, 2012, J AUTISM DEV DISORD, V42, P1790, DOI 10.1007/s10803-011-1415-6
   Schuller B, THE STATE OF PLAY OF
   Schwebel DC, 2014, VIRTUAL REAL-LONDON, V18, P5, DOI 10.1007/s10055-013-0238-5
   Shane HC, 2008, J AUTISM DEV DISORD, V38, P1499, DOI 10.1007/s10803-007-0527-5
   Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
   Smith MJL, 2010, NEUROPSYCHOLOGIA, V48, P2777, DOI 10.1016/j.neuropsychologia.2010.03.008
   Soulieres I, THE LEVEL AND NATURE
   Spreckley M, 2009, J PEDIATR-US, V154, P338, DOI 10.1016/j.jpeds.2008.09.012
   Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
   Trevarthen C, 2013, FRONT INTEGR NEUROSC, V10, DOI [10.3389/fnint.2013.00049, DOI 10.3389/FNINT.2013.00049]
   Vesperini S, ENCEPHALE IN PRESS
   Vicari S, 2000, ACTA PAEDIATR, V89, P836, DOI 10.1080/080352500750043756
   Wainer AL, 2011, RES AUTISM SPECT DIS, V5, P96, DOI 10.1016/j.rasd.2010.08.002
   Williams C, 2002, AUTISM, V6, P71, DOI 10.1177/1362361302006001006
NR 68
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JUL 1
PY 2014
VL 5
AR 37
DI 10.1186/2040-2392-5-37
PG 17
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA AL4AQ
UT WOS:000339075500001
PM 25018866
ER

PT J
AU Becerra, TA
   von Ehrenstein, OS
   Heck, JE
   Olsen, J
   Arah, OA
   Jeste, SS
   Rodriguez, M
   Ritz, B
AF Becerra, Tracy A.
   von Ehrenstein, Ondine S.
   Heck, Julia E.
   Olsen, Jorn
   Arah, Onyebuchi A.
   Jeste, Shafali S.
   Rodriguez, Michael
   Ritz, Beate
TI Autism Spectrum Disorders and Race, Ethnicity, and Nativity: A
   Population-Based Study
SO PEDIATRICS
LA English
DT Article
DE autistic disorder; emigration and immigration; epidemiology; continental
   population groups
ID DIAGNOSTIC OBSERVATION SCHEDULE; FOLIC ACID SUPPLEMENTATION; AMBIENT
   AIR-POLLUTION; NON-HISPANIC WHITE; COUNTRY-OF-ORIGIN; LOW-BIRTH-WEIGHT;
   UNITED-STATES; RISK-FACTORS; VITAMIN-D; REPRODUCTIVE AGE
AB OBJECTIVE: Our understanding of the influence of maternal race/ethnicity and nativity and childhood autistic disorder (AD) in African Americans/blacks, Asians, and Hispanics in the United States is limited. Phenotypic differences in the presentation of childhood AD in minority groups may indicate etiologic heterogeneity or different thresholds for diagnosis. We investigated whether the risk of developing AD and AD phenotypes differed according to maternal race/ethnicity and nativity.
   METHODS: Children born in Los Angeles County with a primary AD diagnosis at ages 3 to 5 years during 1998-2009 were identified and linked to 1995-2006 California birth certificates (7540 children with AD from a cohort of 1 626 354 births). We identified a subgroup of children with AD and a secondary diagnosis of mental retardation and investigated heterogeneity in language and behavior.
   RESULTS: We found increased risks of being diagnosed with AD overall and specifically with comorbid mental retardation in children of foreign-born mothers who were black, Central/South American, Filipino, and Vietnamese, as well as among US-born Hispanic and African American/black mothers, compared with US-born whites. Children of US African American/black and foreign-born black, foreign-born Central/South American, and US-born Hispanic mothers were at higher risk of exhibiting an AD phenotype with both severe emotional outbursts and impaired expressive language than children of US-born whites.
   CONCLUSIONS: Maternal race/ethnicity and nativity are associated with offspring's AD diagnosis and severity. Future studies need to examine factors related to nativity and migration that may play a role in the etiology as well as identification and diagnosis of AD in children.
C1 [Becerra, Tracy A.; Heck, Julia E.; Olsen, Jorn; Arah, Onyebuchi A.; Ritz, Beate] Univ Calif Los Angeles, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA.
   [von Ehrenstein, Ondine S.] Univ Calif Los Angeles, Dept Community Hlth Sci, Fielding Sch Publ Hlth, Los Angeles, CA USA.
   [Jeste, Shafali S.] Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA USA.
   [Rodriguez, Michael] Univ Calif Los Angeles, Dept Family Med, Los Angeles, CA USA.
RP Ritz, B (reprint author), Fielding Sch Publ Hlth, Dept Epidemiol, Box 951772,650 Charles E Young Dr, Los Angeles, CA 90095 USA.
EM britz@ucla.edu
RI Heck, Julia/B-5230-2009; Ritz, Beate/E-3043-2015
FU University of California Los Angeles (UCLA) Graduate Division;
   California Center for Population Research, UCLA - Eunice Kennedy Shriver
   National Institute of Child Health and Human Development [R24HD041022];
   NIEHS of the National Institutes of Health [R21ES022389]; National
   Institutes of Health (NIH)
FX FUNDING: This research was sponsored by the University of California Los
   Angeles (UCLA) Graduate Division, the California Center for Population
   Research, UCLA, supported by infrastructure grant R24HD041022 from the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development and by NIEHS of the National Institutes of Health under
   award number R21ES022389. Funded by the National Institutes of Health
   (NIH).
CR Acevedo-Garcia D, 2007, SOC SCI MED, V65, P2503, DOI 10.1016/j.socscimed.2007.06.033
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, INT DIS
   [Anonymous], 2002, MMWR SURV SUMM S2, V2014, P1
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Bakare MO, 2011, AFR J PSYCHIATRY, V14, P208, DOI [http://dx.doi.org/10.4314/ajpsy.v14i3.3, 10.4314/ajpsy.v14i3.3]
   Barnevik-Olsson M, 2008, DEV MED CHILD NEUROL, V50, P598, DOI 10.1111/j.1469-8749.2008.03036.x
   Becerra TA, 2013, ENVIRON HEALTH PERSP, V121, P380, DOI 10.1289/ehp.1205827
   California Department of Developmental Services, 2002, AUT SPECTR DIS BEST
   California Department of Developmental Services, 2007, AUT SPECTR DIS CHANG
   Campagna AM, 2013, MAYO CLIN PROC, V88, P31, DOI 10.1016/j.mayocp.2012.07.027
   Cavalli-Sforza T, 2005, NUTR REV, V63, pS77, DOI 10.1301/nr.2005.dec.S77-S80
   Chaidez V, 2012, AUTISM, V16, P381, DOI 10.1177/1362361311434787
   Chung I, 2010, INT J SOC PSYCHIATR, V56, P436, DOI 10.1177/0020764009105647
   COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
   Cuccaro ML, 2007, AM J MED GENET B, V144B, P1022, DOI 10.1002/ajmg.b.30535
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Flores MES, 2012, WOMEN HEALTH ISS, V22, pE501, DOI 10.1016/j.whi.2012.07.005
   Gammage S, 2007, MIGRATION INFORM SOU
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   GILLBERG C, 1987, BRIT J PSYCHIAT, V150, P856, DOI 10.1192/bjp.150.6.856
   Grant WB, 2010, J AM MED DIR ASSOC, V11, P617, DOI 10.1016/j.jamda.2010.03.013
   Hamilton TG, 2011, SOC SCI MED, V73, P1551, DOI 10.1016/j.socscimed.2011.07.026
   HINTON WL, 1993, J NERV MENT DIS, V181, P113, DOI 10.1097/00005053-199302000-00007
   Hjern A, 2012, SCAND J PUBLIC HEALT, V40, P255, DOI 10.1177/1403494812459610
   Jaranson JM, 2004, AM J PUBLIC HEALTH, V94, P591, DOI 10.2105/AJPH.94.4.591
   Jarquin VG, 2011, J DEV BEHAV PEDIATR, V32, P179, DOI 10.1097/DBP.0b013e31820b4260
   Johnson H, 2013, IMMIGRANTS CALIFORNI
   Keen DV, 2010, BRIT J PSYCHIAT, V196, P274, DOI 10.1192/bjp.bp.109.065490
   Kocovska E, 2012, RES DEV DISABIL, V33, P1541, DOI 10.1016/j.ridd.2012.02.015
   Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
   LaSalle JM, 2012, EPIGENETIC EPIDEMIOL, P321
   Lindert J, 2009, SOC SCI MED, V69, P246, DOI 10.1016/j.socscimed.2009.04.032
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Los Angeles Almanac, 2000, LANG SPOK HOM LOS AN
   Magnusson C, 2012, BRIT J PSYCHIAT, V201, P109, DOI 10.1192/bjp.bp.111.095125
   McInnes LA, 2005, BMC PSYCHIATRY, V5, P1
   McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
   Michalski D, 2010, 2007 APA SURVEY PYSC
   Miyake K, 2012, ADV EXP MED BIOL, V724, P91, DOI 10.1007/978-1-4614-0653-2_7
   Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
   Pedersen A, 2012, PEDIATRICS, V129, pE629, DOI 10.1542/peds.2011-1145
   Pfortmueller CA, 2012, WIEN KLIN WOCHENSCHR, V124, P647, DOI 10.1007/s00508-012-0227-9
   Rastogi S, 2011, BLACK POPULATION 201
   Ren A, 2007, PUBLIC HEALTH NUTR, V10, P762, DOI 10.1017/S1368980007246786
   Ritz B, 2007, AM J EPIDEMIOL, V166, P1045, DOI 10.1093/aje/kwm181
   Roberts AL, 2013, JAMA PSYCHIAT, V70, P508, DOI 10.1001/jamapsychiatry.2013.447
   Romero CX, 2012, J HEALTH CARE POOR U, V23, P604, DOI 10.1353/hpu.2012.0065
   Schieve LA, 2012, DISABIL HEALTH J, V5, P18, DOI 10.1016/j.dhjo.2011.09.001
   Schmidt RJ, 2012, AM J CLIN NUTR, V96, P80, DOI 10.3945/ajcn.110.004416
   Skeldon R, 1996, J INT AFF, V49, P434
   Smitasiri S, 2005, NUTR REV, V63, pS81, DOI 10.1301/nr.2005.dec.S81-S86
   Smith J, 2006, MIGRATION FORMATION
   State of California Department of Developmental Services, 1986, DIAGN INF INSTR
   Stoner R, 2014, NEW ENGL J MED, V370, P1209, DOI 10.1056/NEJMoa1307491
   Suren P, 2013, JAMA-J AM MED ASSOC, V309, P570, DOI 10.1001/jama.2012.155925
   Terrazas A, 2010, MIGRATION INFORM SOU
   Urban Institute, 2006, CHILDR IMM FACTS FIG
   US Census Bureau, LOS ANG COUNT QUICKF
   US Census Bureau, HISP AM NUMB
   US Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Chronic Disease Prevention and Health Promotion, 2010, REG PLUS SUIT PUBL A
   Wagner J, 2013, J IMMIGR MINOR HEALT, V15, P1065, DOI 10.1007/s10903-012-9715-2
   Yamashiro G, 1997, SOC WORK, V42, P176
   Yang QH, 2007, AM J CLIN NUTR, V85, P1409
   Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
   Yetley EA, 2008, AM J CLIN NUTR, V88, p558S
   Yi Y, 2013, CHILDREN AUTISM RISE
   Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
   Zerbo O, 2013, J AUTISM DEV DISORD, V43, P25, DOI 10.1007/s10803-012-1540-x
NR 74
TC 2
Z9 2
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2014
VL 134
IS 1
BP E63
EP E71
DI 10.1542/peds.2013-3928
PG 9
WC Pediatrics
SC Pediatrics
GA AK9UZ
UT WOS:000338774800009
PM 24958588
ER

PT J
AU Kasari, C
   Lawton, K
   Shih, W
   Barker, TV
   Landa, R
   Lord, C
   Orlich, F
   King, B
   Wetherby, A
   Senturk, D
AF Kasari, Connie
   Lawton, Kathy
   Shih, Wendy
   Barker, Tyson V.
   Landa, Rebecca
   Lord, Catherine
   Orlich, Felice
   King, Bryan
   Wetherby, Amy
   Senturk, Damla
TI Caregiver-Mediated Intervention for Low-Resourced Preschoolers With
   Autism: An RCT
SO PEDIATRICS
LA English
DT Article
DE autism; early intervention; parent-child interactions; joint attention
ID RANDOMIZED CONTROLLED-TRIAL; JOINT ATTENTION; SPECTRUM DISORDER;
   CHILDREN; PLAY; TODDLERS; ENGAGEMENT; DIAGNOSIS; MODEL
AB OBJECTIVES: To compare 2 short-term, community caregiver training interventions for preschool-aged children with Autism Spectrum Disorder who had low resources. Low resource was defined by the US Department of Housing and Urban Development low-income index or 1 "indicator," (eg, Medicaid eligibility). Child outcomes focused on joint engagement, joint attention, and play.
   METHODS: Participants included 112 families of a child who had Autism Spectrum Disorder who met criteria for being low-resourced and who were randomly assigned to 1 of 2 3-month interventions, group caregiver education or individualized caregiver-mediated intervention (CMM). Children were assessed for social communication skills pre- and post-treatment, and followed up at 3 months.
   RESULTS: All children improved in joint engagement and initiating joint attention, with significantly greater improvement by the CMM group. Outcomes on play skills were mixed, with improvement of symbolic play for the CMM group and no change in functional play skills. Joint engagement maintained over time for the CMM group, and initiating joint attention maintained for both groups over time.
   CONCLUSIONS: This study is among the first randomized trials comparing 2 active interventions with a large sample of low-resourced families. Results suggest improvements in core autism deficits of joint engagement, joint attention, and symbolic play with relatively brief, caregiver-mediated interventions, but additional support is necessary to maintain and generalize these gains over time.
C1 [Kasari, Connie; Shih, Wendy; Senturk, Damla] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
   [Kasari, Connie] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
   [Lawton, Kathy] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
   [Lawton, Kathy] Ohio State Univ, Dept Special Educ, Columbus, OH 43210 USA.
   [Barker, Tyson V.] Univ Maryland, Dept Human Dev & Quantitat Methodol, College Pk, MD 20742 USA.
   [Landa, Rebecca] Kennedy Krieger Inst, Baltimore, MD USA.
   [Lord, Catherine] Weill Cornell Med Ctr, New York, NY USA.
   [Orlich, Felice; King, Bryan] Childrens Hosp Seattle, Seattle, WA USA.
   [Wetherby, Amy] Florida State Univ, Dept Clin Sci, Tallahassee, FL 32306 USA.
RP Kasari, C (reprint author), Univ Calif Los Angeles, Semel Inst 68 268, Los Angeles, CA 90024 USA.
EM ckasari@mednet.ucla.edu
FU Maternal and Child Health Research Program, Maternal and Child Health
   Bureau (Combating Autism Act Initiative), Health Resources and Services
   Administration, Department of Health and Human Services [UA3 MC 11055
   AIR-B]
FX All phases of this study were supported by grant UA3 MC 11055 AIR-B from
   the Maternal and Child Health Research Program, Maternal and Child
   Health Bureau (Combating Autism Act Initiative), Health Resources and
   Services Administration, Department of Health and Human Services.
CR Adamson LB, 2004, CHILD DEV, V75, P1171, DOI 10.1111/j.1467-8624.2004.00732.x
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Cidav Z, 2012, PEDIATRICS, V129, P617, DOI 10.1542/peds.2011-2700
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Kasari C., 2013, AM J PLAY, V6, P124
   Kasari C, 2005, CLIN NEUROPSYCHIATRY, V2, P380
   Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
   Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
   LIFTER K, 1993, J EARLY INTERVENTION, V17, P139
   Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
   Mullen E., 1997, MULLEN SCALES EARLY
   Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61
   MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
   Patterson SY, 2012, AUTISM, V16, P498, DOI 10.1177/1362361311413398
   Rogers SJ, 2012, J AM ACAD CHILD PSY, V51, P1052, DOI 10.1016/j.jaac.2012.08.003
   Seibert J. M., 1982, INFANT MENT HEALTH J, V3, P244, DOI DOI 10.1002/1097-0355(198224)3:4<244::AID-IMHJ2280030406>3.0.CO;2-R
   Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
   Siller M, 2013, J AUTISM DEV DISORD, V43, P540, DOI 10.1007/s10803-012-1584-y
   Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
   Tek S, 2012, J AUTISM DEV DISORD, V42, P1967, DOI 10.1007/s10803-012-1445-8
   UNGERER JA, 1981, J AM ACAD CHILD PSY, V20, P318, DOI 10.1016/S0002-7138(09)60992-4
NR 28
TC 3
Z9 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2014
VL 134
IS 1
BP E72
EP E79
DI 10.1542/peds.2013-3229
PG 8
WC Pediatrics
SC Pediatrics
GA AK9UZ
UT WOS:000338774800010
PM 24958585
ER

PT J
AU Sorrell, J
   Salvaggio, H
   Garg, A
   Guo, LL
   Duck, SC
   Paller, AS
AF Sorrell, Jennifer
   Salvaggio, Heather
   Garg, Abhimanyu
   Guo, Lulu
   Duck, Stephen C.
   Paller, Amy S.
TI Eruptive Xanthomas Masquerading as Molluscum Contagiosum
SO PEDIATRICS
LA English
DT Article
DE behavior eating; BMI; dermatology; autism
ID HYPERTRIGLYCERIDEMIA SECONDARY; HYPOTHYROIDISM; INSULIN
AB Eruptive xanthomas are cutaneous manifestations of hyperlipidemias in which lipids accumulate in large foam cells within the skin. They classically present as crops of 1-to 4-mm yellow-orange papules and are often associated with extreme hypertriglyceridemia. We describe a 12-year-old boy with autism who was thought to have widespread molluscum contagiosum for a year before dermatologic consultation was obtained. Recognition of eruptive xanthomas led to the discovery of massive hypertriglyceridemia (serum triglycerides 6853 mg/dL) and diabetes mellitus. Through medical intervention, including insulin and fenofibrate therapy, and dietary modification with weight loss, the xanthomas cleared during the subsequent months, and his serum triglyceride levels nearly normalized.
C1 [Sorrell, Jennifer; Salvaggio, Heather; Guo, Lulu; Paller, Amy S.] Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA.
   [Sorrell, Jennifer; Salvaggio, Heather; Guo, Lulu; Paller, Amy S.] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Chicago, IL 60611 USA.
   [Garg, Abhimanyu] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA.
   [Duck, Stephen C.] Univ Chicago, Sch Med, Dept Pediat, Chicago, IL 60637 USA.
RP Paller, AS (reprint author), Northwestern Univ, Sch Med, Dept Dermatol, 676 North St Clair St,Suite 1600, Chicago, IL 60611 USA.
EM apaller@northwestern.edu
CR Chang HY, 2003, ARCH DERMATOL, V139, P1045, DOI 10.1001/archderm.139.8.1045
   Chernev K, 1985, Vutr Boles, V24, P42
   Dotsch J, 2001, PEDIATRICS, V108, part. no., DOI 10.1542/peds.108.5.e96
   Garcia MA, 2005, PEDIATR DERMATOL, V22, P11, DOI 10.1111/j.1525-1470.2005.22102.x
   Geyer AS, 2004, ARCH DERMATOL, V140, P617, DOI 10.1001/archderm.140.5.617-b
   Jetha MM, 2012, PEDIATR DIABETES, V13, P444, DOI 10.1111/j.1399-5448.2011.00843.x
   Kesim M, 2011, J RES MED SCI, V16, P1525
   Kock S, 1996, DEUT MED WOCHENSCHR, V121, P323
   Loeckermann S, 2010, CLIN EXP DERMATOL, V35, P565, DOI 10.1111/j.1365-2230.2009.03477.x
   Mathes EFD, 2010, PEDIATR ANN, V39, P124, DOI 10.3928/00904481-20100223-03
   Naik N S, 2001, Dermatol Online J, V7, P11
   Parihar Ravi Kumar, 2012, Indian J Endocrinol Metab, V16, P643, DOI 10.4103/2230-8210.98032
   Park JR, 2005, J KOREAN MED SCI, V20, P502
   SCHAEFER EJ, 1986, J CLIN INVEST, V78, P1206, DOI 10.1172/JCI112704
   Shinozaki S, 2005, DIABETES RES CLIN PR, V70, P183, DOI 10.1016/j.diabres.2005.03.023
   Teitelbaum M, 2000, PSYCHOSOMATICS, V41, P448, DOI 10.1176/appi.psy.41.5.448
   Teitelbaum M, 2001, PSYCHOSOMATICS, V42, P440, DOI 10.1176/appi.psy.42.5.440
   TELTSCHER J, 1989, J AM ACAD DERMATOL, V21, P1147, DOI 10.1016/S0190-9622(89)70319-4
NR 18
TC 0
Z9 0
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2014
VL 134
IS 1
BP E257
EP E260
DI 10.1542/peds.2013-2108
PG 4
WC Pediatrics
SC Pediatrics
GA AK9UZ
UT WOS:000338774800031
PM 24918225
ER

PT J
AU Bekhet, AK
AF Bekhet, Abir K.
TI Self-Assessed Health in Caregivers of Persons With Autism Spectrum
   Disorder: Associations With Depressive Symptoms, Positive Cognitions,
   Resourcefulness, and Well-Being
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Depressive symptoms; positive cognitions; resourcefulness; self-assessed
   health
ID RELOCATION ADJUSTMENT; STRESS PROLIFERATION; PARENTING STRESS; CHILDREN;
   MOTHERS; ADOLESCENTS; ASD; TODDLERS; OPTIMISM; ELDERS
AB PURPOSE: Caregiving for children with autism spectrum disorder (ASD) can affect family caregivers' self-assessed health. The purpose of this study was to determine whether depressive symptoms, positive cognitions, resourcefulness, and well-being will differ significantly among those who rated their health as fair, good, or excellent.
   DESIGN AND METHODS: This study is a secondary analysis of 109 ASD caregivers who were recruited from the Interactive ASD Network.
   FINDINGS: Depression was significantly lower among those who rated their health as excellent than among those who rated their health as fair. Positive cognitions, resourcefulness, and well-being were significantly higher among those who rated their health as excellent than among those who rated their health as fair.
   PRACTICE IMPLICATIONS: Interventions to enhance caregivers' positive cognitions, resourcefulness, and well-being are recommended.
C1 Marquette Univ, Coll Nursing, Milwaukee, WI 53233 USA.
RP Bekhet, AK (reprint author), Marquette Univ, Coll Nursing, Milwaukee, WI 53233 USA.
EM abir.bekhet@marquette.edu
FU Way Klinger Young Scholar Award
FX The parent study is funded by the Way Klinger Young Scholar Award
   awarded to Dr. Abir Bekhet. The author acknowledges the editorial
   assistance of Elizabeth M. Tornquist (University of North Carolina at
   Chapel Hill).
CR Aikens J. E., 1992, J CONSULT CLIN PSYCH, V60, P1113
   Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
   Altiere J., 2009, J INTELLECT DEV DIS, V34, P142
   [Anonymous], 2000, DIANG STAT MAN MENT
   Baker BL, 2005, J INTELL DISABIL RES, V49, P575, DOI 10.1111/j.1365-2788.2005.00691.x
   Begley S., 2012, US AUTISM RATES REAC
   Bekhet Abir K, 2011, Issues Ment Health Nurs, V32, P35, DOI 10.3109/01612840.2010.521618
   Bekhet Abir K, 2012, Issues Ment Health Nurs, V33, P650
   Bekhet AK, 2011, WESTERN J NURS RES, V33, P121, DOI 10.1177/0193945910381763
   Bekhet AK, 2008, WESTERN J NURS RES, V30, P113, DOI 10.1177/0193945907309309
   Bekhet AK, 2013, WESTERN J NURS RES, V35, P1074, DOI 10.1177/0193945913482191
   Benjak T, 2009, CROAT MED J, V50, P403, DOI 10.3325/cmj.2009.50.403
   Bennett K., 2010, PASW STAT SPSS PRACT
   Benson P, 2008, AUTISM, V12, P47, DOI 10.1177/1362361307085269
   Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
   Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
   BRADEN CJ, 1990, NURS RES, V39, P42
   Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634
   Centers for Disease Control and Prevention, 2008, MMWR SURVEILLANCE SU, V61
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   Dupuy H., 1984, ASSESSMENT QUALITY L, P170
   Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
   Ekas NV, 2009, J AUTISM DEV DISORD, V39, P706, DOI 10.1007/s10803-008-0673-4
   Fazio A F, 1977, Vital Health Stat 2, P1
   Gray DE, 2006, J INTELL DISABIL RES, V50, P970, DOI 10.1111/j.1365-2788.2006.00933.x
   Haeffel G. J., 2014, CLIN PSYCHOL SCI, V2, P75, DOI DOI 10.1177/2167702613485075
   Hoffman CD, 2008, FOCUS AUTISM DEV DIS, V23, P155, DOI 10.1177/1088357608316271
   Idler E. L., 1991, J GERONTOL, V46, P55
   Karst JS, 2012, CLIN CHILD FAM PSYCH, V15, P247, DOI 10.1007/s10567-012-0119-6
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P455, DOI 10.1016/j.rasd.2008.09.005
   Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
   Musil C M, 1998, Issues Ment Health Nurs, V19, P207
   Phetrasuwan S, 2009, J SPEC PEDIATR NURS, V14, P157, DOI 10.1111/j.1744-6155.2009.00188.x
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Roter DL, 2004, MED EDUC, V38, P145, DOI 10.1046/j.1365-2923.2004.01754.x
   Rush A. J., 2000, COMPREHENSIVE TXB PS, P2167
   Smith LE, 2008, J AUTISM DEV DISORD, V38, P876, DOI 10.1007/s10803-007-0461-6
   Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
   Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015
   Taylor JE, 2003, QUAL LIFE RES, V12, P31, DOI 10.1023/A:1022052804109
   Tintle N, 2011, INT J GERIATR PSYCH, V26, P1292, DOI 10.1002/gps.2681
   Tomislav B., 2009, CROAT MED J, V50, P403
   Unützer Jürgen, 2002, Ment Health Serv Res, V4, P245, DOI 10.1023/A:1020924901595
   Van Breda AD, 2001, RESILIENCE THEORY LI
   Zauszniewski J A, 1995, J Nurs Meas, V3, P31
   Zauszniewski Jaclene A, 2006, J Nurs Meas, V14, P57, DOI 10.1891/106137406780954315
   Zauszniewski J. A., 2006, ENCY NURSING RES, P256
   Zauszniewski Jaclene A, 2007, Issues Ment Health Nurs, V28, P575, DOI 10.1080/01612840701354547
   Zauszniewski Jaclene A, 2009, Issues Ment Health Nurs, V30, P142, DOI 10.1080/01612840802557204
   Zauszniewski Jaclene A, 2010, Issues Ment Health Nurs, V31, P483, DOI 10.3109/01612841003602687
   Zauszniewski JA, 2002, WESTERN J NURS RES, V24, P728, DOI 10.1177/019394502237380
NR 51
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD JUL
PY 2014
VL 50
IS 3
BP 210
EP 217
DI 10.1111/ppc.12046
PG 8
WC Nursing; Psychiatry
SC Nursing; Psychiatry
GA AL6WT
UT WOS:000339274900009
PM 24206628
ER

PT J
AU Horiuchi, F
   Oka, Y
   Uno, H
   Kawabe, K
   Okada, F
   Saito, I
   Tanigawa, T
   Ueno, S
AF Horiuchi, Fumie
   Oka, Yasunori
   Uno, Hiroyuki
   Kawabe, Kentaro
   Okada, Fumi
   Saito, Isao
   Tanigawa, Takeshi
   Ueno, Shu-ichi
TI Age- and sex-related emotional and behavioral problems in children with
   autism spectrum disorders: Comparison with control children
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE autism spectrum disorders; emotional and behavioral problems; Strengths
   and Difficulties Questionnaire
ID DIFFICULTIES QUESTIONNAIRE; MENTAL-HEALTH; PREVALENCE; ADOLESCENTS;
   STRENGTHS; BRITAIN; RATES; RISK; SDQ
AB Aim: Children with autism spectrum disorders (ASD) often present with emotional and behavioral problems, which could change the clinical course, especially during childhood, and affect future quality of life. The aim of this study was to clarify the age- and sex-related differences of these problems in ASD.
   Methods: The study subjects were 173 patients with ASD (age: 4-16 years) and 173 age-and sex-matched community children (control group). The parent version of the Strengths and Difficulties Questionnaire was used for comparison of the emotional and behavioral problems between the two groups.
   Results: The Strengths and Difficulties Questionnaire scores were significantly higher in children with ASD than controls at all ages. The score of total difficulties was significantly higher in girls with ASD than in boys, while the score in male controls was significantly higher than in female controls. Age-related differences in emotional and behavioral problems were observed both in children with ASD and controls, but the characteristics were different: in children with ASD, emotional symptoms and peer problems in both sexes and conduct problems in girls increased significantly with age, while none of the problems in the controls changed with age except for a decrease in the score of hyperactivity/inattention developmentally in both sexes. Prosocial behaviors of children with ASD and controls showed small changes with age.
   Conclusion: Emotional and behavioral problems are common in children with ASD and showed age-and sex-related differences. Our study emphasizes the importance of recognizing those differences among children with ASD for early intervention.
C1 [Horiuchi, Fumie; Kawabe, Kentaro; Okada, Fumi; Ueno, Shu-ichi] Ehime Univ, Grad Sch Med, Dept Neuropsychiat & Neurosci, Toon, Japan.
   [Saito, Isao; Tanigawa, Takeshi] Ehime Univ, Grad Sch Med, Dept Publ Hlth, Toon City, Ehime 7910295, Japan.
   [Saito, Isao] Ehime Univ, Grad Sch Med, Dept Basic Nursing & Hlth Sci, Toon City, Ehime 7910295, Japan.
   [Oka, Yasunori] Ehime Univ, Grad Sch Med, Ctr Sleep Med, Toon City, Ehime 7910295, Japan.
   [Uno, Hiroyuki] Hyogo Univ Teachers Educ, Dept Educ Disabled Children, Nagoya, Aichi, Japan.
   [Okada, Fumi] Nagoya Univ, Ctr Dev Clin Psychol & Psychiat, Nagoya, Aichi 4648601, Japan.
RP Horiuchi, F (reprint author), Ehime Univ, Grad Sch Med, Dept Neuropsychiat & Neurosci, Toon City, Ehime 7910295, Japan.
EM matsufu@m.ehime-u.ac.jp
CR Allen CW, 2007, J AUTISM DEV DISORD, V37, P1272, DOI 10.1007/s10803-006-0279-7
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Centers for Disease Control Prevention, 2007, MMWR-MORBID MORTAL W, V9, P12
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Emerson E, 2007, BRIT J PSYCHIAT, V191, P493, DOI 10.1192/bjp.bp.107.038729
   Estes AM, 2007, AM J MENT RETARD, V112, P439, DOI 10.1352/0895-8017(2007)112[439:LOIFPP]2.0.CO;2
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Goodman A, 2011, J CHILD PSYCHOL PSYC, V52, P100, DOI 10.1111/j.1469-7610.2010.02278.x
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8
   Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
   Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Hsiao MN, 2013, RES DEV DISABIL, V34, P254, DOI 10.1016/j.ridd.2012.08.001
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Matsuishi T, 2008, BRAIN DEV-JPN, V30, P410, DOI 10.1016/j.braindev.2007.12.003
   Mattila ML, 2010, J AUTISM DEV DISORD, V40, P1080, DOI 10.1007/s10803-010-0958-2
   Mazzone L, 2012, ANN GEN PSYCHIATR, V11, P13
   Oka Y, 2011, CHIRYO, V93, P198
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Skokauskas N, 2012, J INTELL DISABIL RES, V56, P248, DOI 10.1111/j.1365-2788.2011.01423.x
   Steinhausen HC, 2004, EUR CHILD ADOLES PSY, V13, P214, DOI 10.1007/s00787-004-0400-4
   Sturm H, 2004, DEV MED CHILD NEUROL, V46, P444, DOI 10.1017/S0012162204000738
   youthinmind, 1997, SDQ INF RES PROF STR
NR 26
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD JUL
PY 2014
VL 68
IS 7
BP 542
EP 550
DI 10.1111/pcn.12164
PG 9
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA AL4PB
UT WOS:000339113800007
PM 24447342
ER

PT J
AU Jain, A
   Spencer, D
   Yang, WY
   Kelly, JP
   Newschaffer, CJ
   Johnson, J
   Marshall, J
   Azocar, F
   Tabb, LP
   Dennen, T
AF Jain, Anjali
   Spencer, Donna
   Yang, Wenya
   Kelly, Jonathan P.
   Newschaffer, Craig J.
   Johnson, Jonathan
   Marshall, Jaclyn
   Azocar, Francisca
   Tabb, Loni Philip
   Dennen, Taylor
TI Injuries Among Children With Autism Spectrum Disorder
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE administrative claims; autism spectrum disorder; child injury;
   commercial insurance
ID DEVELOPMENTAL-DISABILITIES; UNINTENTIONAL INJURY; UNITED-STATES; US
   CHILDREN; RISK; ADOLESCENTS; INTERVALS; RATES; AGE
AB OBJECTIVE: We compared risk of injury among children with autism spectrum. disorder (ASD) to those without ASD, adjusting for demographic and clinical characteristics.
   METHODS: We used claims data from 2001 to 2009 from a commercial health plan in the United States. A validated ASD case identification algorithm identified 33,565 children (ages 0-20 years) with ASD and 138,876 children without. Counting process models tested the association between ASD status and injury episodes with separate regressions run for children during different age periods.
   RESULTS: Unadjusted results demonstrated that children with ASD had a 12% greater injury risk than children without ASD (hazard ratio [HR] = 1.119; P < .001). After including demographic variables, the HR was 1.03 (P < .05); after controlling for co-occurring conditions, such as seizures, depression, etc, HR decreased to 0.889 (P < .001). For the age period analysis, HR values were as follows: for 0 to 2 years, HR 1.141; 3 to 5 years, HR 1.282; 6 to 10 years, HR not significant; and 11 to 20 years, HR 0.634 (P < .05 for all significant results).
   CONCLUSIONS: Children with ASD have more injuries than children without ASD. After controlling for demographic factors and co-occurring conditions, children with ASD are at lower risk of injury, suggesting that co-occurring conditions or the ways these conditions interact with ASD is related to injuries. Clinicians should understand that injury risk in children with ASD may be driven by co-occurring conditions. Treating these conditions could thus decrease injury risk as well as have other benefits. Injury prevention interventions are especially warranted for younger children with ASD and those with seizures, depression, visual impairment, or attention-deficit disorders.
C1 [Jain, Anjali; Yang, Wenya; Kelly, Jonathan P.; Marshall, Jaclyn; Dennen, Taylor] Lewin Grp, Falls Church, VA 22042 USA.
   [Spencer, Donna; Johnson, Jonathan] OptumInsight Life Sci, Eden Prairie, MN USA.
   [Newschaffer, Craig J.; Tabb, Loni Philip] Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA.
   [Azocar, Francisca] OptumHlth Behav Solut, San Francisco, CA USA.
RP Jain, A (reprint author), Lewin Grp, 3130 Fairview Pk Dr,Suite 500, Falls Church, VA 22042 USA.
EM anjali.jain@lewin.com
FU National Institute of Mental Health (NIMH), National Institutes of
   Health, Department of Health and Human Services [HHSN-271-2010-00033-C]
FX This project was funded by the National Institute of Mental Health
   (NIMH), National Institutes of Health, Department of Health and Human
   Services, under contract HHSN-271-2010-00033-C. The authors acknowledge
   the following for their contributions: Brady Post and Corey Lipow of the
   Lewin Group; James Burke, Jeffrey McPheeters, Thomas Horstman, and Felix
   Cao of OptumInsight; and Lindsey Lawer of Drexel University.
CR Agran PF, 2001, PEDIATRICS, V108, part. no., DOI 10.1542/peds.108.3.e45
   Agran PF, 2003, PEDIATRICS, V111, pE683, DOI 10.1542/peds.111.6.e683
   Anderson C, 2012, PEDIATRICS, V130, P870, DOI 10.1542/peds.2012-0762
   Brenner RA, 2013, INT J INJ CONTROL SA, V20, P259, DOI 10.1080/17457300.2012.696662
   Burke JP, 2014, AUTISM, V18, P321, DOI 10.1177/1362361312467709
   Centers for Disease Control and Prevention, PROT ON YOU LOV CHIL
   Centers for Disease Control and Prevention, PATT UN INJ 0 19 YEA
   Gilchrist Julie, 2012, Morbidity and Mortality Weekly Report, V61, P270
   Duerden EG, 2012, J AUTISM DEV DISORD, V42, P2460, DOI 10.1007/s10803-012-1497-9
   Guo Z, 2008, METHOD INFORM MED, V47, P107, DOI 10.3414/ME0478
   Huang P, 2012, J DEV BEHAV PEDIATR, V33, P70, DOI 10.1097/DBP.0b013e31823a43b7
   Lee LC, 2008, RES DEV DISABIL, V29, P247, DOI 10.1016/j.ridd.2007.05.002
   LELAND NL, 1994, J DEV BEHAV PEDIATR, V15, P402
   McDermott S, 2008, J AUTISM DEV DISORD, V38, P626, DOI 10.1007/s10803-007-0426-9
   Patrick AR, 2010, PHARMACOEPIDEM DR S, V19, P1263, DOI 10.1002/pds.2037
   Rowe R, 2004, J PEDIATR PSYCHOL, V29, P119, DOI 10.1093/jpepsy/jsh015
   Sherrard J, 2001, Inj Prev, V7, P56, DOI 10.1136/ip.7.1.56
   Sinclair SA, 2008, AM J PUBLIC HEALTH, V98, P1510, DOI 10.2105/AJPH.2006.097097
   Slayter EM, 2006, MENT RETARD, V44, P212, DOI 10.1352/0047-6765(2006)44[212:IPACAA]2.0.CO;2
   Stroupe KT, 2001, J POLICY ANAL MANAG, V20, P525, DOI 10.1002/pam.1006
   Xiang HY, 2005, AM J PUBLIC HEALTH, V95, P1970, DOI 10.2105/AJPH.2004.057505
NR 21
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
EI 1876-2867
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD JUL-AUG
PY 2014
VL 14
IS 4
BP 390
EP 397
PG 8
WC Pediatrics
SC Pediatrics
GA AL0OC
UT WOS:000338825200012
PM 24976351
ER

PT J
AU Zuckerman, KE
   Lindly, OJ
   Bethell, CD
   Kuhlthau, K
AF Zuckerman, Katharine E.
   Lindly, Olivia J.
   Bethell, Christina D.
   Kuhlthau, Karen
TI Family Impacts Among Children With Autism Spectrum Disorder: The Role of
   Health Care Quality
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE autism spectrum disorder; children with special health care needs;
   delivery of health care; integrated; disabled children; family burden;
   family health; financial burden; quality of health care
ID FINANCIAL BURDEN; NATIONAL-SURVEY; AGED CHILDREN; UNITED-STATES; MEDICAL
   HOME; NEEDS; EMPLOYMENT; INSURANCE; SERVICES; DISABILITIES
AB OBJECTIVE: To compare health care quality and family employment and financial impacts among children with special health care needs (CSHCN) with autism spectrum disorder (CSHCN + ASD), CSHCN with functional limitations (CSHCN + FL), and CSHCN lacking these conditions (other CSHCN); to test whether high health care quality was associated with reduced family impacts among CSHCN + ASD.
   METHODS: Data from the 2009-2010 National Survey of CSHCN were used to compare 3025 CSHCN + ASD, 6505 CSHCN + FL, and 28,296 other CSHCN. Weighted multivariate logistic regression analyses examined 6 age-relevant, federally defined health care quality indicators and 5 family financial and employment impact indicators. Two composite measures were additionally used: I) receipt of care that met all age-relevant quality indicators; and 2) had of the 5 adverse family impacts.
   RESULTS: Across all health care quality indicators, CSHCN + ASD fared poorly, with only 7.4% meeting all age-relevant indicators. CSHCN + ASD had worse health care quality than other CSHCN, including CSHCN + FL. CSHCN + ASD also had high rates of adverse family impact, with over half experiencing adverse impacts. Rates of adverse family impact were higher in CSHCN + ASD than other CSHCN, including CSHCN + FL. Among CSHCN + ASD, those whose health care that met federal quality standards were less likely to have multiple adverse family impacts than CSHCN + ASD whose health care did not meet federal quality standards.
   CONCLUSIONS: CSHCN + ASD are more prone to experience poor health care quality and family impacts than other CSHCN, even CSHCN + FL. Receipt of care meeting federal quality standards may potentially lessen adverse family impacts for CSHCN + ASD.
C1 [Zuckerman, Katharine E.; Lindly, Olivia J.; Bethell, Christina D.] Oregon Hlth & Sci Univ, Child & Adolescent Hlth Measurement Initiat, Portland, OR 97239 USA.
   [Zuckerman, Katharine E.] Oregon Hlth & Sci Univ, Div Gen Pediat, Portland, OR 97239 USA.
   [Lindly, Olivia J.] Oregon State Univ, Dept Publ Hlth, Corvallis, OR 97331 USA.
   [Kuhlthau, Karen] Massachusetts Gen Hosp Children, Ctr Child & Adolescent Hlth Res & Policy, Boston, MA USA.
   [Kuhlthau, Karen] Harvard Univ, Sch Med, Dept Pediat, Div Gen Pediat, Cambridge, MA 02138 USA.
RP Zuckerman, KE (reprint author), Oregon Hlth & Sci Univ, Mail Code CDRC P 707 SW Gaines Rd, Portland, OR 97239 USA.
EM zuckerma@ohsu.edu
FU National Institute of Mental Health Mentored Career Development Award
   [K23MH095828]; Nancy Lurie Marks Foundation; US Department of Health and
   Human Services, Health Resources and Services Administration, Maternal
   and Child Health Bureau [1-U59-MC06980-01]
FX Supported in part by National Institute of Mental Health Mentored Career
   Development Award K23MH095828 (Dr Zuckerman), the Nancy Lurie Marks
   Foundation (Dr Kuhlthau), and Cooperative Agreement 1-U59-MC06980-01
   from the US Department of Health and Human Services, Health Resources
   and Services Administration, Maternal and Child Health Bureau (Dr
   Bethell). The authors thank Julie Robertson, MPH, MSW, for assistance
   with data analysis.
CR Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
   Almansour MA, 2013, NEUROSCIENCES, V18, P58
   [Anonymous], 2012, MMWR SURVEILLENCE SU, V61, P1
   Association of Maternal and Child Health Programs, 2012, AFF CAR ACT CHILDR Y
   Bethell CD, 2002, AMBUL PEDIATR, V2, P38, DOI 10.1367/1539-4409(2002)002<0038:ICWSHC>2.0.CO;2
   Blumberg S.J., 2013, NATL HLTH STAT REPOR, V65, P1
   Boulet SL, 2009, ARCH PEDIAT ADOL MED, V163, P19, DOI 10.1001/archpediatrics.2008.506
   Brachlow AE, 2007, ARCH PEDIAT ADOL MED, V161, P399, DOI 10.1001/archpedi.161.4.399
   Bramlett MD, 2009, MATERN CHILD HLTH J, V13, P151, DOI 10.1007/s10995-008-0339-z
   Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
   Carbone PS, 2009, J AUTISM DEV DISORD, V40, P317, DOI DOI 10.1007/S10803-009-0874-5
   Centers for Disease Control and Prevention; National Center for Health Statistics, 2011, STAT LOC AR INT TEL
   Davidoff AJ, 2004, PEDIATRICS, V114, P394, DOI 10.1542/peds.114.2.394
   Duarte CS, 2005, AUTISM, V9, P416, DOI 10.1177/1362361305056081
   Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1710, DOI 10.1007/s10803-008-0556-8
   Galbraith AA, 2005, HEALTH SERV RES, V40, P1722, DOI 10.1111/j.1475-6773.2005.00421.x
   Ghandour RM, 2014, ACAD PEDIATR, V14, P92, DOI 10.1016/j.acap.2013.10.001
   Glasgow RE, 2012, HEALTH AFFAIR, V31, P497, DOI 10.1377/hlthaff.2010.1295
   Gurney JG, 2006, ARCH PEDIAT ADOL MED, V160, P825, DOI 10.1001/archpedi.160.8.825
   Heck KE, 2000, AM J PUBLIC HEALTH, V90, P1856, DOI 10.2105/AJPH.90.12.1856
   Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
   Houtrow A. J., 2011, Vulnerable Children and Youth Studies, V6, P222, DOI 10.1080/17450128.2011.580144
   Houtrow AJ, 2011, ACAD PEDIATR, V11, P508, DOI 10.1016/j.acap.2011.08.004
   Knapp C, 2013, MATERN CHILD HLTH J, V17, P1658, DOI 10.1007/s10995-012-1179-4
   Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
   Kuhlthau K, 2010, MATERN CHILD HLTH J, V14, P155, DOI 10.1007/s10995-008-0434-1
   Kuhlthau K, 2005, MATERN CHILD HLTH J, V9, P207, DOI 10.1007/s10995-005-4870-x
   Lollar JD, 2012, PEDIATRICS, V129, pe714
   Maglione Margaret A, 2012, Pediatrics, V130 Suppl 2, pS169, DOI 10.1542/peds.2012-0900O
   McPherson M, 1998, PEDIATRICS, V102, P137, DOI 10.1542/peds.102.1.137
   Montes G, 2008, PEDIATRICS, V122, pE202, DOI 10.1542/peds.2007-3037
   Shattuck PT, 2006, PEDIATRICS, V117, P1028, DOI 10.1542/peds.2005-1516
   Sikora Darryn M, 2012, Pediatrics, V130 Suppl 2, pS91, DOI 10.1542/peds.2012-0900G
   Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
   Thomas KC, 2012, MATERN CHILD HLTH J, V16, P1636, DOI 10.1007/s10995-011-0862-1
   US Department of Health and Human Services, HLTH PEOPL 2020 MAT
   Wazana A, 2007, J AM ACAD CHILD PSY, V46, P721, DOI 10.1097/chi.0b013e31804a7f3b
   Wegner LM, 2009, PEDIATR ANN, V38, P57
NR 38
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
EI 1876-2867
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD JUL-AUG
PY 2014
VL 14
IS 4
BP 398
EP 407
PG 10
WC Pediatrics
SC Pediatrics
GA AL0OC
UT WOS:000338825200013
PM 24976352
ER

PT J
AU Broder-Fingert, S
   Brazauskas, K
   Lindgren, K
   Iannuzzi, D
   Van Cleave, J
AF Broder-Fingert, Sarabeth
   Brazauskas, Karissa
   Lindgren, Kristen
   Iannuzzi, Dorothea
   Van Cleave, Jeanne
TI Prevalence of Overweight and Obesity in a Large Clinical Sample of
   Children With Autism
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE autism; obesity; overweight
ID SPECTRUM DISORDERS; CHILDHOOD OBESITY; PHYSICAL-ACTIVITY; UNITED-STATES;
   WEIGHT-GAIN; HEALTH; ADOLESCENTS; DISABILITIES; MEDICATIONS
AB BACKGROUND: Overweight and obesity are major pediatric public health problems in the United States; however, limited data exist on the prevalence and correlates of overnutrition in children with autism.
   METHODS: Through a large integrated health care system's patient database, we identified 6672 children ages 2 to 20 years with an assigned ICD-9 code of autism (299.0), Asperger syndrome (299.8), and control subjects from 2008 to 2011 who had at least 1 weight and height recorded in the same visit. We calculated age-adjusted, sex-adjusted body mass index and classified children as overweight (body mass index 85th to 95th percentile) or obese (>= 95th percentile). We used multinomial logistic regression to compare the odds of overweight and obesity between groups. We then used logistic regression to evaluate factors associated with overweight and obesity in children with autism, including demographic and clinical characteristics.
   RESULTS: Compared to control subjects, children with autism and Asperger syndrome had significantly higher odds of over-weight (odds ratio, 95% confidence interval: autism 2.24, 1.74-2.88; Asperger syndrome 1.49, 1.12-1.97) and obesity (autism 4.83, 3.85-6.06; Asperger syndrome 5.69, 4.50-7.21). Among children with autism, we found a higher odds of obesity in older children (aged 12-15 years 1.87, 1.33-2.63; aged 16-20 years 1.94, 1.39-2.71) compared to children aged 6 to 11 years. We also found higher odds of overweight and obesity in those with public insurance (overweight 1.54, 1.25-1.89; obese 1.16, 1.02-1.40) and with co-occurring sleep disorder (obese 1.23, 1.00-1.53).
   CONCLUSIONS: Children with autism and Asperger syndrome had significantly higher odds of overweight and obesity than control subjects. Older age, public insurance, and co-occurring sleep disorder were associated with overweight or obesity in this population.
C1 [Broder-Fingert, Sarabeth; Iannuzzi, Dorothea; Van Cleave, Jeanne] Ctr Child & Adolescent Hlth Res & Policy, Div Gen Pediat, Boston, MA USA.
   [Brazauskas, Karissa; Lindgren, Kristen] MassGen Hosp Children, Boston, MA USA.
RP Broder-Fingert, S (reprint author), MassGen Hosp Children, Ctr Child & Adolescent Hlth Res & Policy, Div Gen Pediat, 100 Cambridge St,Room 1542, Boston, MA 02114 USA.
EM sbroder-finger@partners.org
FU APA Resident Investigator Award
FX Supported in part by the APA Resident Investigator Award.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barnard L, 2002, J PSYCHOPHARMACOL, V16, P93
   Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
   Biro FM, 2010, AM J CLIN NUTR, V91, p1499S, DOI 10.3945/ajcn.2010.28701B
   Blumberg S. J., 2013, 65 NAT CTR HLTH STAT
   Curtin C, 2014, HARVARD REV PSYCHIAT, V22, P93, DOI 10.1097/HRP.0000000000000031
   Curtin Carol, 2005, BMC Pediatr, V5, P48, DOI 10.1186/1471-2431-5-48
   Curtin C, 2010, BMC PEDIATR, V10, DOI 10.1186/1471-2431-10-11
   Ebbeling CB, 2002, LANCET, V360, P473, DOI 10.1016/S0140-6736(02)09678-2
   Egan AM, 2013, CHILD OBES, V9, P125, DOI 10.1089/chi.2012.0028
   Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
   Han JC, 2010, LANCET, V375, P1737, DOI 10.1016/S0140-6736(10)60171-7
   Hinckson EA, 2013, RES DEV DISABIL, V34, P1170, DOI 10.1016/j.ridd.2012.12.006
   Kuczmarski RJ, 2002, VITAL HLTH STAT, P11
   Long SK, 2008, HLTH INSURANCE COVER
   Lumeng JC, 2010, PEDIATRICS, V126, P574, DOI 10.1542/peds.2010-1873
   Maayan L, 2011, J CHILD ADOL PSYCHOP, V21, P517, DOI 10.1089/cap.2011.0015
   Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
   Manning SE, 2011, PEDIATRICS, V127, P1043, DOI 10.1542/peds.2010-2943
   Marcason W, 2009, J AM DIET ASSOC, V109, P572, DOI 10.1016/j.jada.2009.01.013
   Murray ML, 2014, PSYCHOPHARMACOLOGY, V231, P1011, DOI 10.1007/s00213-013-3140-7
   Nalichowski Ruth, 2006, AMIA Annu Symp Proc, P1044
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Pan CY, 2008, J AUTISM DEV DISORD, V38, P1292, DOI 10.1007/s10803-007-0518-6
   Phillips KL, MATERN CHIL IN PRESS
   Rimmer JH, 2010, J INTELL DISABIL RES, V54, P787, DOI 10.1111/j.1365-2788.2010.01305.x
   Sachs GS, 1999, J CLIN PSYCHIAT, V60, P16
   Schreck KA, 2004, J AUTISM DEV DISORD, V34, P433, DOI 10.1023/B:JADD.0000037419.78531.86
   Zuckerman KE, 2013, PEDIATRICS, V132, P445, DOI 10.1542/peds.2013-0383
   Zuckerman KE, J AUSTISM D IN PRESS
NR 31
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
EI 1876-2867
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD JUL-AUG
PY 2014
VL 14
IS 4
BP 408
EP 414
PG 7
WC Pediatrics
SC Pediatrics
GA AL0OC
UT WOS:000338825200014
PM 24976353
ER

PT J
AU Gentile, I
   Zappulo, E
   Bonavolta, R
   Maresca, R
   Messana, T
   Buonomo, AR
   Portella, G
   Sorrentino, R
   Settimi, A
   Pascotto, A
   Borgia, G
   Bravaccio, C
AF Gentile, Ivan
   Zappulo, Emanuela
   Bonavolta, Raffaele
   Maresca, Roberta
   Messana, Tullio
   Buonomo, Antonio Riccardo
   Portella, Giuseppe
   Sorrentino, Rosanna
   Settimi, Alessandro
   Pascotto, Antonio
   Borgia, Guglielmo
   Bravaccio, Carmela
TI Prevalence and Titre of Antibodies to Cytomegalovirus and Epstein-Barr
   Virus in Patients with Autism Spectrum Disorder
SO IN VIVO
LA English
DT Article
DE Autism spectrum disorder; CMV; EBV; antibody titre
ID HERPES-SIMPLEX ENCEPHALITIS; MULTIPLE-SCLEROSIS; MATERNAL INFECTION;
   INFANTILE-AUTISM; FETAL-BRAIN; VITAMIN-D; CHILDREN; ASSOCIATION;
   RUBELLA; ACTIVATION
AB Background/Aim: The etiology of autism spectrum disorders (ASD) is currently unknown. Few studies have explored the role of Cytomegalovirus (CMV) and Epstein Barr Virus (EBV) as potential etiological factors of ASD. The aim of the present study was to evaluate the seropositivity rate and antibody titre to CMV and EBV in children with ASD compared to same-aged healthy controls. Patients and Methods: We compared the seropositivity rate and titre of antibodies to CMV and EBV in 54 children with ASD (19 with autistic disorder and 35 with non-autistic disorder ASD) and in 46 controls. Results: Seropositivity rate and titre of the two antibodies were not dissimilar between cases and controls. However, considering only patients with ASD, those seropositive for CMV tended to test worse to the major severity scales than the seronegative ones. Conclusion: Titre and seropositivity rate of antibodies to CMV and EBV are similar between children with ASD and healthy controls.
C1 [Gentile, Ivan; Zappulo, Emanuela; Buonomo, Antonio Riccardo; Borgia, Guglielmo] Univ Naples Federico II, Dept Clin Med & Surg, Infect Dis Sect, I-80131 Naples, Italy.
   [Bonavolta, Raffaele; Portella, Giuseppe; Sorrentino, Rosanna; Settimi, Alessandro; Bravaccio, Carmela] Univ Naples Federico II, Dept Med Translat Sci, I-80131 Naples, Italy.
   [Maresca, Roberta; Messana, Tullio; Pascotto, Antonio] Univ Naples 2, Naples, Italy.
RP Gentile, I (reprint author), Univ Naples Federico II, Dept Clin Med & Surg, Infect Dis Sect, Via S Pansini 5, I-80131 Naples, Italy.
EM ivan.gentile@unina.it
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   [Anonymous], 2012, MMWR SURVEILL SUMM, V61, P1
   Ascherio A, 2010, J NEUROIMMUNE PHARM, V5, P271, DOI 10.1007/s11481-010-9201-3
   Becker KG, 2010, MED HYPOTHESES, V74, P7, DOI 10.1016/j.mehy.2009.08.033
   Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
   Cannell JJ, 2008, MED HYPOTHESES, V70, P750, DOI 10.1016/j.mehy.2007.08.016
   CHESS S, 1971, J AUTISM CHILD SCHIZ, V1, P33, DOI 10.1007/BF01537741
   CIARANELLO AL, 1995, ANNU REV NEUROSCI, V18, P101
   Desmond MM, 1970, ADV TERATOL, V4, P39
   DEYKIN EY, 1979, AM J EPIDEMIOL, V109, P628
   Dogan Y, 2011, FETAL DIAGN THER, V30, P141, DOI 10.1159/000330636
   Engel SM, 2011, EPIDEMIOLOGY, V22, P486, DOI 10.1097/EDE.0b013e31821daf1c
   Eyles DW, 2012, FRONT NEUROENDOCRIN, V11, P11
   FOWLER KB, 1992, NEW ENGL J MED, V326, P663, DOI 10.1056/NEJM199203053261003
   Garbett KA, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.24
   Gentile I, 2013, IN VIVO, V27, P377
   Gentile I, 2010, BMC INFECT DIS, V10, DOI 10.1186/1471-2334-10-49
   Gentile I, 2012, PLATELETS, V6, P6
   Gentile I, 2013, IN VIVO, V27, P843
   Gentile I, 2013, MED HYPOTHESES, V81, P26, DOI 10.1016/j.mehy.2013.04.002
   Gentile I, 2014, VIVO IN PRESS
   Gentile I, 2013, OPEN J PSYCHIAT, V3, P18
   GHAZIUDDIN M, 1992, J AUTISM DEV DISORD, V22, P107, DOI 10.1007/BF01046406
   GILLBERG C, 1986, J AUTISM DEV DISORD, V16, P369, DOI 10.1007/BF01531665
   Grant William B, 2009, Dermatoendocrinol, V1, P223
   Griffiths R, 2006, GDMS GRIFFITHS MENTA
   IVARSSON SA, 1990, NEUROPEDIATRICS, V21, P102, DOI 10.1055/s-2008-1071471
   Jankosky C, 2012, VIRUS RES, V163, P424, DOI 10.1016/j.virusres.2011.11.010
   JORGENSEN OS, 1982, ACTA PSYCHIAT SCAND, V66, P42, DOI 10.1111/j.1600-0447.1982.tb00913.x
   Kawashti Maha I S, 2006, Egypt J Immunol, V13, P99
   Kawatani M, 2010, PEDIATR INT, V52, P304, DOI 10.1111/j.1442-200X.2010.03027.x
   King CR, 2011, MED HYPOTHESES, V76, P653, DOI 10.1016/j.mehy.2011.01.024
   Kitajima J, 2012, PEDIATR DEVEL PATHOL, V15, P151, DOI 10.2350/11-05-1034-CR.1
   KNOBLOCH H, 1975, PEDIATRICS, V55, P182
   Libbey JE, 2005, J NEUROVIROL, V11, P1, DOI 10.1080/13550280590900553
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MARKOWITZ PI, 1983, J AUTISM DEV DISORD, V13, P249, DOI 10.1007/BF01531564
   Mora M, 2009, INVEST CLIN, V50, P315
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Patterson PH, 2002, CURR OPIN NEUROBIOL, V12, P115, DOI 10.1016/S0959-4388(02)00299-4
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Schultz ST, 2010, ACTA NEUROBIOL EXP, V70, P227
   Schultz ST, 2008, AUTISM, V12, P293, DOI 10.1177/1362361307089518
   Shelton JF, 2012, ENVIRON HEALTH PERSP, V120, P944, DOI 10.1289/ehp.1104553
   Shi LM, 2003, J NEUROSCI, V23, P297
   Singh VK, 2009, ANN CLIN PSYCHIATRY, V21, P148
   Singh VK, 1998, CLIN IMMUNOL IMMUNOP, V89, P105, DOI 10.1006/clin.1998.4588
   Singh VK, 2002, J BIOMED SCI, V9, P359, DOI 10.1159/000065007
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   STAGNO S, 1985, NEW ENGL J MED, V313, P1270, DOI 10.1056/NEJM198511143132006
   STUBBS EG, 1978, J AUTISM CHILD SCHIZ, V8, P37, DOI 10.1007/BF01550276
   SUMAYA CV, 1980, ARCH NEUROL-CHICAGO, V37, P94
   Sundstrom P, 2004, NEUROLOGY, V62, P2277
   Sweeten TL, 2004, J AUTISM DEV DISORD, V34, P583, DOI 10.1007/s10803-004-2552-y
   Ufret-Vincenty RL, 1998, J EXP MED, V188, P1725, DOI 10.1084/jem.188.9.1725
   Yamashita Y, 2003, J AUTISM DEV DISORD, V33, P455, DOI 10.1023/A:1025023131029
NR 57
TC 1
Z9 1
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JUL-AUG
PY 2014
VL 28
IS 4
BP 621
EP 626
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AK9VU
UT WOS:000338777500028
PM 24982232
ER

PT J
AU Gentile, I
   Zappulo, E
   Bonavolta, R
   Maresca, R
   Riccio, MP
   Buonomo, AR
   Portella, G
   Settimi, A
   Pascotto, A
   Borgia, G
   Bravaccio, C
AF Gentile, Ivan
   Zappulo, Emanuela
   Bonavolta, Raffaele
   Maresca, Roberta
   Riccio, Maria Pia
   Buonomo, Antonio Riccardo
   Portella, Giuseppe
   Settimi, Alessandro
   Pascotto, Antonio
   Borgia, Guglielmo
   Bravaccio, Carmela
TI Exposure to Varicella Zoster Virus Is Higher in Children with Autism
   Spectrum Disorder than in Healthy Controls. Results from a Case-control
   Study
SO IN VIVO
LA English
DT Article
DE Autism spectrum disorder; etiopathogenesis; prevalence; titre; VZV
ID CONGENITAL CYTOMEGALOVIRUS-INFECTION; HERPES-SIMPLEX ENCEPHALITIS;
   MATERNAL IMMUNE ACTIVATION; VITAMIN-D; RISK-FACTORS; FETAL-BRAIN;
   ASSOCIATION; ANTIBODIES; EXPRESSION; SYMPTOMS
AB Background/Aim: Autism spectrum disorder (ASD) is a group of central nervous system disorders lacking a definite etiology. The aim of the present study was to compare the exposure rate and titer of antibodies to Varicella Zoster Virus (VZV) in children with ASD and in healthy controls. Patients and Methods: We enrolled 54 children with ASD and 46 control individuals. Results: The exposure rate and titer of anti-VZV antibodies were significantly higher in children with ASD compared to controls (59% vs. 39% and 694 mIU/ml vs. 94 mIU/ml, respectively). Conclusion: In the present case-control study, exposure to VZV was found to be independently associated with ASD.
C1 [Gentile, Ivan; Zappulo, Emanuela; Buonomo, Antonio Riccardo; Borgia, Guglielmo] Univ Naples Federico II, Infect Dis Sect, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Bonavolta, Raffaele; Portella, Giuseppe; Settimi, Alessandro; Bravaccio, Carmela] Univ Naples Federico II, Dept Med Translat Sci, I-80131 Naples, Italy.
   [Maresca, Roberta; Riccio, Maria Pia; Pascotto, Antonio] Univ Naples 2, Naples, Italy.
RP Gentile, I (reprint author), Univ Naples Federico II, Infect Dis Sect, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
EM ivan.gentile@unina.it
CR American Psychiatric Association, 2000, DIAG STAT MAN MENT D
   American Psychiatric Association, 2013, DIAG STAT MAN MENT D
   ANLAR B, 1994, J CHILD NEUROL, V9, P104
   Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
   Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
   Cannell JJ, 2008, MED HYPOTHESES, V70, P750, DOI 10.1016/j.mehy.2007.08.016
   CHESS S, 1971, J AUTISM CHILD SCHIZ, V1, P33, DOI 10.1007/BF01537741
   Comi AM, 1999, J CHILD NEUROL, V14, P388, DOI 10.1177/088307389901400608
   DELONG GR, 1981, ARCH NEUROL-CHICAGO, V38, P191
   Desmond MM, 1970, ADV TERATOL, V4, P39
   DEYKIN EY, 1979, AM J EPIDEMIOL, V109, P628
   Dogan Y, 2011, FETAL DIAGN THER, V30, P141, DOI 10.1159/000330636
   Engel SM, 2011, EPIDEMIOLOGY, V22, P486, DOI 10.1097/EDE.0b013e31821daf1c
   Eyles DW, 2012, FRONT NEUROENDOCRIN, V11, P11
   FOWLER KB, 1992, NEW ENGL J MED, V326, P663, DOI 10.1056/NEJM199203053261003
   Garbett KA, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.24
   Gentile I, 2013, IN VIVO, V27, P377
   Gentile I, 2010, BMC INFECT DIS, V10, DOI 10.1186/1471-2334-10-49
   Gentile I, 2013, IN VIVO, V27, P843
   Gentile I, 2013, PLATELETS, V24, P574, DOI 10.3109/09537104.2012.735721
   Gentile I, 2013, J PSYCHIAT, V3, P18
   Gentile I, 2013, MED HYPOTHESES, V81, P26, DOI 10.1016/j.mehy.2013.04.002
   GHAZIUDDIN M, 1992, J AUTISM DEV DISORD, V22, P107, DOI 10.1007/BF01046406
   GILLBERG C, 1986, J AUTISM DEV DISORD, V16, P369, DOI 10.1007/BF01531665
   Grant William B, 2009, Dermatoendocrinol, V1, P223
   Gregg NM, 1991, AUST NZ J OPHTHALMOL, V19, P267
   Griffiths R, 2006, GDMS GRIFFITHS MENTA
   IVARSSON SA, 1990, NEUROPEDIATRICS, V21, P102, DOI 10.1055/s-2008-1071471
   Jankosky C, 2012, VIRUS RES, V163, P424, DOI 10.1016/j.virusres.2011.11.010
   JORGENSEN OS, 1982, ACTA PSYCHIAT SCAND, V66, P42, DOI 10.1111/j.1600-0447.1982.tb00913.x
   Jyonouchi H, 2001, J NEUROIMMUNOL, V120, P170, DOI 10.1016/S0165-5728(01)00421-0
   Kawashti Maha I S, 2006, Egypt J Immunol, V13, P99
   Kawatani M, 2010, PEDIATR INT, V52, P304, DOI 10.1111/j.1442-200X.2010.03027.x
   Keil A, 2010, EPIDEMIOLOGY, V21, P805, DOI 10.1097/EDE.0b013e3181f26e3f
   King CR, 2011, MED HYPOTHESES, V76, P653, DOI 10.1016/j.mehy.2011.01.024
   Kitajima J, 2012, PEDIATR DEVEL PATHOL, V15, P151, DOI 10.2350/11-05-1034-CR.1
   Kuhn M, 2012, MED HYPOTHESES, V78, P606, DOI 10.1016/j.mehy.2012.01.037
   Libbey JE, 2005, J NEUROVIROL, V11, P1, DOI 10.1080/13550280590900553
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
   MARKOWITZ PI, 1983, J AUTISM DEV DISORD, V13, P249, DOI 10.1007/BF01531564
   Meguid NA, 2010, J ALTERN COMPLEM MED, V16, P641, DOI 10.1089/acm.2009.0349
   Molloy CA, 2010, DEV MED CHILD NEUROL, V52, P969, DOI 10.1111/j.1469-8749.2010.03704.x
   Mora M, 2009, INVEST CLIN, V50, P315
   Patterson PH, 2002, CURR OPIN NEUROBIOL, V12, P115, DOI 10.1016/S0959-4388(02)00299-4
   Persico AM, 2010, J NEUROVIROL, V16, P332, DOI 10.3109/13550284.2010.504765
   Persico AM, 2012, AUTISM RES TREAT, V2012, P2
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Singh VK, 2009, ANN CLIN PSYCHIATRY, V21, P148
   Singh VK, 1998, CLIN IMMUNOL IMMUNOP, V89, P105, DOI 10.1006/clin.1998.4588
   Siniscalco D, 2012, J AUTISM DEV DISORD, V42, P1403, DOI 10.1007/s10803-011-1373-z
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   STAGNO S, 1985, NEW ENGL J MED, V313, P1270, DOI 10.1056/NEJM198511143132006
   STUBBS EG, 1978, J AUTISM CHILD SCHIZ, V8, P37, DOI 10.1007/BF01550276
   Sweeten TL, 2004, J AUTISM DEV DISORD, V34, P583, DOI 10.1007/s10803-004-2552-y
   Taylor B, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003219
   Yamashita Y, 2003, J AUTISM DEV DISORD, V33, P455, DOI 10.1023/A:1025023131029
NR 58
TC 0
Z9 0
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JUL-AUG
PY 2014
VL 28
IS 4
BP 627
EP 631
PG 5
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AK9VU
UT WOS:000338777500029
PM 24982233
ER

PT J
AU Gentile, I
   Zappulo, E
   Bonavolta, R
   Maresca, R
   Riccio, MP
   Buonomo, AR
   Portella, G
   Vallefuoco, L
   Settimi, A
   Pascotto, A
   Borgia, G
   Bravaccio, C
AF Gentile, Ivan
   Zappulo, Emanuela
   Bonavolta, Raffaele
   Maresca, Roberta
   Riccio, Maria Pia
   Buonomo, Antonio Riccardo
   Portella, Giuseppe
   Vallefuoco, Luca
   Settimi, Alessandro
   Pascotto, Antonio
   Borgia, Guglielmo
   Bravaccio, Carmela
TI Prevalence of Herpes Simplex Virus 1 and 2 Antibodies in Patients with
   Autism Spectrum Disorders
SO IN VIVO
LA English
DT Article
DE Autism spectrum disorder; etiopathogenesis; HSV1; HSV2
ID EPSTEIN-BARR-VIRUS; ENCEPHALITIS; INFECTION; CHILDREN; BRAIN;
   ASSOCIATION; DEFICITS; GENES; ONSET
AB Background/Aim: The etiology of autism spectrum disorder (ASD) is unknown, even though it is hypothesized that a viral infection could trigger this disorder. The aim of this study was to evaluate the seropositivity rate and antibody level of Herpes Simplex Virus 1 (HSV1) and Herpes Simplex Virus 2 (HSV2) in children with ASD compared to same-aged healthy controls. Patients and Methods: We compared seropositivity rate and levels of antibodies to HSV1/2 in 54 children with ASD (19 with autistic disorder and 35 with non-autistic ASD) and in 46 controls. Results: Seropositivity rate and levels of anti-HSV1/2 were not dissimilar between cases and controls. Exposure to HSV2 was minimal. Conclusion: Rate of contact with HSV1 and HSV2 assessed by the mean of detection of specific antibodies was similar between children with ASD and healthy controls.
C1 [Gentile, Ivan; Zappulo, Emanuela; Buonomo, Antonio Riccardo; Borgia, Guglielmo] Univ Naples Federico II, Infect Dis Sect, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Bonavolta, Raffaele; Portella, Giuseppe; Vallefuoco, Luca; Settimi, Alessandro; Bravaccio, Carmela] Univ Naples Federico II, Dept Med Translat Sci, I-80131 Naples, Italy.
   [Maresca, Roberta; Riccio, Maria Pia; Pascotto, Antonio] Univ Naples 2, Naples, Italy.
RP Gentile, I (reprint author), Univ Naples Federico II, Infect Dis Sect, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
EM ivan.gentile@unina.it
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
   Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
   Cannell JJ, 2008, MED HYPOTHESES, V70, P750, DOI 10.1016/j.mehy.2007.08.016
   Carter CJ, 2013, PATHOG DIS, V69, P240, DOI 10.1111/2049-632X.12077
   DELONG GR, 1981, ARCH NEUROL-CHICAGO, V38, P191
   Engel SM, 2011, EPIDEMIOLOGY, V22, P486, DOI 10.1097/EDE.0b013e31821daf1c
   Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011
   Garbett KA, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.24
   Gentile I, 2013, IN VIVO, V27, P377
   Gentile I, 2010, BMC INFECT DIS, V10, DOI 10.1186/1471-2334-10-49
   Gentile I, 2013, IN VIVO, V27, P843
   Gentile I, 2013, PLATELETS, V24, P574, DOI 10.3109/09537104.2012.735721
   Gentile I, 2013, MED HYPOTHESES, V81, P26, DOI 10.1016/j.mehy.2013.04.002
   Gentile I, 2013, OPEN J PSYCHIAT, V3, P18
   GHAZIUDDIN M, 1992, J AUTISM DEV DISORD, V22, P107, DOI 10.1007/BF01046406
   GILLBERG C, 1986, J AUTISM DEV DISORD, V16, P369, DOI 10.1007/BF01531665
   GILLBERG IC, 1991, DEV MED CHILD NEUROL, V33, P920
   GREER MK, 1989, J AUTISM DEV DISORD, V19, P317, DOI 10.1007/BF02211849
   Griffiths R, 2006, GDMS GRIFFITHS MENTA
   JORGENSEN OS, 1982, ACTA PSYCHIAT SCAND, V66, P42, DOI 10.1111/j.1600-0447.1982.tb00913.x
   Lintas C, 2010, J NEUROVIROL, V16, P141, DOI 10.3109/13550281003685839
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mora M, 2009, INVEST CLIN, V50, P315
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Shi LM, 2003, J NEUROSCI, V23, P297
   Singh VK, 1998, CLIN IMMUNOL IMMUNOP, V89, P105, DOI 10.1006/clin.1998.4588
   Singh VK, 2002, J BIOMED SCI, V9, P359, DOI 10.1159/000065007
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   STAGNO S, 1985, NEW ENGL J MED, V313, P1270, DOI 10.1056/NEJM198511143132006
   Sundstrom P, 2004, NEUROLOGY, V62, P2277
   Taylor B, 2013, BMJ OPEN, V3, P2013
NR 34
TC 0
Z9 0
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JUL-AUG
PY 2014
VL 28
IS 4
BP 667
EP 671
PG 5
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA AK9VU
UT WOS:000338777500035
PM 24982239
ER

PT J
AU Atkinson, MA
   Simpson, A
   Skarratt, PA
   Cole, GG
AF Atkinson, Mark A.
   Simpson, Andrew
   Skarratt, Paul A.
   Cole, Geoff G.
TI Is social inhibition of return due to action co-representation?
SO ACTA PSYCHOLOGICA
LA English
DT Article
DE Social IOR; Joint action; Social attention; Biological motion; Objects;
   Co-representation
ID OBJECT-CENTERED INHIBITION; INFLUENCE FREDS ACTION; VISUAL-ATTENTION;
   SELECTIVE ATTENTION; POINTING MOVEMENTS; OTHERS ACTIONS; REACTION-TIME;
   MOTOR; AUTISM; GAZE
AB When two individuals alternate reaching responses to visual targets presented on a shared workspace, one individual is slower to respond to targets occupying the same position as their partner's previous response. This phenomenon is thought to be due to processes that inhibit the initiation of a movement to a location recently acted upon. However, two distinct forms of the inhibition account have been posited, one based on inhibition of an action, the other based on inhibition of an action and location. Furthermore, an additional recent explanation suggests the phenomenon is due to mechanisms that give rise to action congruency effects. Thus the three different theories differ in the degree to which action co-representation plays a role in the effect. The aim of the present work was to examine these competing accounts. Three experiments demonstrated that when identical actions are made, the effect is modulated by the configuration of the visual stimuli acted upon and the perceptual demands of the task. In addition, when the co-actors perform different actions to the same target, the effect is still observed. These findings support the hypothesis that this particular joint action phenomenon is generated via social cues that induce location-based inhibition of return rather than being due to shared motor co-representations. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Atkinson, Mark A.; Simpson, Andrew; Cole, Geoff G.] Univ Essex, Ctr Brain Sci, Colchester CO4 3SQ, Essex, England.
   [Skarratt, Paul A.] Univ Hull, Dept Psychol, Kingston Upon Hull HU6 7RX, N Humberside, England.
RP Atkinson, MA (reprint author), Univ Essex, Ctr Brain Sci, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
EM matkinb@essex.ac.uk; ggcole@essex.ac.uk
CR Atmaca S, 2008, SOC NEUROSCI, V3, P410, DOI 10.1080/17470910801900908
   Atmaca S., 2011, EXPT BRAIN RES, P1
   Belopolsky AV, 2008, ACTA PSYCHOL, V128, P56, DOI 10.1016/j.actpsy.2007.09.012
   Blakemore SJ, 2005, NEUROPSYCHOLOGIA, V43, P260, DOI 10.1016/j.neuropsychologia.2004.11.012
   Brass M, 2001, ACTA PSYCHOL, V106, P3, DOI 10.1016/S0001-6918(00)00024-X
   Brass M, 2000, BRAIN COGNITION, V44, P124, DOI 10.1006/brcg.2000.1225
   Calvo-Merino B, 2005, CEREB CORTEX, V15, P1243, DOI 10.1093/cercor/bhi007
   Cole G. G., 2012, PSYCHOL RES, P1
   Dale R, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00355
   DIPELLEGRINO G, 1992, EXP BRAIN RES, V91, P176
   Dolk T, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00084
   Driver J, 1999, VIS COGN, V6, P509
   DUNCAN J, 1984, J EXP PSYCHOL GEN, V113, P501, DOI 10.1037/0096-3445.113.4.501
   Fabbri-Destro M, 2008, PHYSIOLOGY, V23, P171, DOI 10.1152/physiol.00004.2008
   Filimon F., 2007, NEUROIMAGE, V22, P629
   Fischer MH, 2003, PERCEPT PSYCHOPHYS, V65, P379, DOI 10.3758/BF03194569
   Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138
   Friesen CK, 1998, PSYCHON B REV, V5, P490, DOI 10.3758/BF03208827
   Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
   Frischen A, 2009, COGNITION, V111, P212, DOI 10.1016/j.cognition.2009.02.003
   Gallese V, 1996, BRAIN, V119, P593, DOI 10.1093/brain/119.2.593
   Hayes SJ, 2012, NEUROSCI LETT, V506, P346, DOI 10.1016/j.neulet.2011.11.045
   Hayes SJ, 2010, PSYCHOL RES-PSYCH FO, V74, P302, DOI 10.1007/s00426-009-0250-2
   Hommel B, 2009, PSYCHOL RES-PSYCH FO, V73, P512, DOI 10.1007/s00426-009-0234-2
   Howard LA, 1999, J GEN PSYCHOL, V126, P421
   Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
   Jeannerod M, 1999, CURR OPIN NEUROBIOL, V9, P735, DOI 10.1016/S0959-4388(99)00038-0
   Johnson-Frey SH, 2003, NEURON, V39, P1053, DOI 10.1016/S0896-6273(03)00524-5
   Jordan H, 1998, PSYCHON B REV, V5, P504, DOI 10.3758/BF03208829
   Jordan H, 1999, BRIT J PSYCHOL, V90, P495, DOI 10.1348/000712699161576
   Kilner JM, 2003, CURR BIOL, V13, P522, DOI 10.1016/S0960-9822(03)00165-9
   Kingstone A, 1999, PERCEPT PSYCHOPHYS, V61, P1046, DOI 10.3758/BF03207612
   Klein RM, 2000, TRENDS COGN SCI, V4, P138, DOI 10.1016/S1364-6613(00)01452-2
   Knoblich G, 2006, CURR DIR PSYCHOL SCI, V15, P99, DOI 10.1111/j.0963-7214.2006.00415.x
   KWAK HW, 1992, PERCEPT PSYCHOPHYS, V51, P455, DOI 10.3758/BF03211641
   Langton SRH, 2000, J EXP PSYCHOL HUMAN, V26, P747, DOI 10.1037//0096-1523.26.2.747
   Liepelt R, 2008, J EXP PSYCHOL HUMAN, V34, P578, DOI 10.1037/0096-1523.34.3.578
   Mukamel R, 2010, CURR BIOL, V20, P750, DOI 10.1016/j.cub.2010.02.045
   Ondobaka S, 2012, PSYCHOL SCI, V23, P30, DOI 10.1177/0956797611424163
   POSNER MI, 1984, ATTENTION PERFORM, V10, P531
   Prinz W, 1997, EUR J COGN PSYCHOL, V9, P129, DOI 10.1080/713752551
   RAFAL RD, 1989, J EXP PSYCHOL HUMAN, V15, P673, DOI 10.1037/0096-1523.15.4.673
   Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Schuch S, 2007, PERCEPT PSYCHOPHYS, V69, P828, DOI 10.3758/BF03193782
   Sebanz N, 2003, COGNITION, V88, pB11, DOI 10.1016/S0010-0277(03)00043-X
   Sebanz N, 2005, COGN NEUROPSYCHOL, V22, P433, DOI 10.1080/02643290442000121
   Sebanz N, 2006, J COGNITIVE NEUROSCI, V18, P859, DOI 10.1162/jocn.2006.18.5.859
   Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x
   SIMON JR, 1970, J EXP PSYCHOL, V86, P272, DOI 10.1037/h0029961
   Skarratt PA, 2010, ACTA PSYCHOL, V134, P48, DOI 10.1016/j.actpsy.2009.12.003
   Sturmer B, 2000, J EXP PSYCHOL HUMAN, V26, P1746, DOI 10.1037//0096-1523.26.6.1746
   Sumner P, 2004, CURR BIOL, V14, P2259, DOI 10.1016/j.cub.2004.12.021
   Tanaka Y, 1996, VISION RES, V36, P2125, DOI 10.1016/0042-6989(95)00272-3
   TERRY KM, 1994, PERCEPT PSYCHOPHYS, V55, P279, DOI 10.3758/BF03207599
   TIPPER SP, 1991, Q J EXP PSYCHOL-A, V43, P289
   Tipper SP, 1999, PERCEPT PSYCHOPHYS, V61, P50, DOI 10.3758/BF03211948
   Tremblay L, 2005, EXP BRAIN RES, V160, P79, DOI 10.1007/s00221-004-1987-x
   Tsai C.-C., 2011, COGNITION, V118, P135
   Villiger M, 2011, EXP BRAIN RES, V209, P85, DOI 10.1007/s00221-010-2522-x
   Welsh TN, 2005, NEUROSCI LETT, V385, P99, DOI 10.1016/j.neulet.2005.05.013
   Welsh TN, 2009, BRAIN RES, V1248, P141, DOI 10.1016/j.brainres.2008.10.077
   Welsh TN, 2009, BRAIN COGNITION, V71, P64, DOI 10.1016/j.bandc.2009.04.001
   Welsh TN, 2006, EXP BRAIN RES, V174, P167, DOI 10.1007/s00221-006-0433-7
   Welsh TN, 2007, PSYCHON B REV, V14, P950, DOI 10.3758/BF03194127
   Wilson M, 2005, PSYCHOL BULL, V131, P460, DOI 10.1037/0033-2909.131.3.460
NR 66
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-6918
EI 1873-6297
J9 ACTA PSYCHOL
JI Acta Psychol.
PD JUL
PY 2014
VL 150
BP 85
EP 93
DI 10.1016/j.actpsy.2014.04.003
PG 9
WC Psychology, Experimental
SC Psychology
GA AL0IU
UT WOS:000338811400011
PM 24859672
ER

PT J
AU Zhao, S
   Uono, S
   Yoshimura, S
   Toichi, M
AF Zhao, Shuo
   Uono, Shota
   Yoshimura, Sayaka
   Toichi, Motomi
TI Attention orienting by eye gaze and arrows reveals flexibility to
   environmental changes
SO ACTA PSYCHOLOGICA
LA English
DT Article
DE Orienting attention; Gaze; Arrow; Environmental changes
ID HIGH-FUNCTIONING AUTISM; JOINT ATTENTION; CUES; CHILDREN; SPECTRUM;
   PERCEPTION; DIRECTION; MOVEMENT; CONTEXT; SOUND
AB This study aimed to evaluate the difference in non-predictive cues between gaze and arrows in attention orienting. Attention orienting was investigated with gaze or arrows as separate cues in a simple condition (i.e., block design) in Experiment 1 and in an unpredictable condition (i.e., randomized design) in Experiment 2. Two kinds of sound (voice and tone) stimuli were used as targets. Results showed that gaze and arrow cues induced enhanced attention orienting to a voice versus tone target in the block condition. However, in the randomized condition, enhanced attention orienting to a voice versus tone target was found in gaze but not arrow cues. The congruency of the meaning between a social cue (i.e., gaze) and a social target (i.e., voice) was clear in the randomized but not blocked design, because social gaze and non-social arrow cues were implemented in the same block. Thus, attention orienting might be mediated by the associated relationship of cue-target in a randomized condition, as an enhanced orienting effect was found when the associated relationship of cue-target was strong (i.e., social cue and target). The present study suggests that the difference in attention orienting between gaze and arrows is apparent in a randomized design (the unpredictable condition), and people employ a flexibly strategy of orienting to better respond to environmental changes. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Zhao, Shuo; Uono, Shota; Toichi, Motomi] Kyoto Univ, Grad Sch Med, Sch Hlth Sci, Kyoto 6068507, Japan.
   [Yoshimura, Sayaka] Kyoto Univ, Grad Sch Med, Dept Psychiat, Kyoto 6068507, Japan.
   [Zhao, Shuo; Toichi, Motomi] Org Promoting Dev Disorder Res, Kyoto 6068507, Japan.
RP Zhao, S (reprint author), Kyoto Univ, Grad Sch Med, Sch Hlth Sci, Sakyo Ku, 53 Shogoin Kawahara Cho, Kyoto 6068507, Japan.
EM zhaoshuo09@gmail.com
CR (APA) APA, 2000, DIAGN STAT MAN MENT
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bayliss AP, 2010, VIS COGN, V18, P1214, DOI 10.1080/13506285.2010.484657
   Bayliss AP, 2005, BRIT J PSYCHOL, V96, P95, DOI 10.1348/000712604X15626
   Belin P, 2000, NATURE, V403, P309, DOI 10.1038/35002078
   Birmingham E, 2009, PROG BRAIN RES, V176, P309, DOI 10.1016/S0079-6123(09)17618-5
   Borjon JI, 2011, P ROY SOC B-BIOL SCI, V278, P1997, DOI 10.1098/rspb.2010.2306
   Calder A., 2011, OXFORD HDB FACE PERC
   Chawarska K, 2003, CHILD DEV, V74, P1108, DOI 10.1111/1467-8624.00595
   Ekman P., 1976, PICTURES FACIAL AFFE
   Friesen CK, 1998, PSYCHON B REV, V5, P490, DOI 10.3758/BF03208827
   Friesen CK, 2004, J EXP PSYCHOL HUMAN, V30, P319, DOI 10.1037/0096-1523.30.2.319
   Goldberg MC, 2008, J AUTISM DEV DISORD, V38, P1405, DOI 10.1007/s10803-007-0506-x
   Kryzak LA, 2013, J APPL BEHAV ANAL, V46, P674, DOI 10.1002/jaba.73
   Kuhn G, 2011, PSYCHON B REV, V18, P89, DOI 10.3758/s13423-010-0033-1
   Kuhn G, 2009, ATTEN PERCEPT PSYCHO, V71, P314, DOI 10.3758/APP.71.2.314
   Kylliainen A, 2004, J CHILD PSYCHOL PSYC, V45, P435, DOI 10.1111/j.1469-7610.2004.00235.x
   Marotta A, 2013, J AUTISM DEV DISORD, V43, P917, DOI 10.1007/s10803-012-1636-3
   Marotta A, 2012, BRAIN COGNITION, V80, P361, DOI 10.1016/j.bandc.2012.08.001
   Marotta A, 2012, J EXP PSYCHOL HUMAN, V38, P326, DOI 10.1037/a0023959
   Naoi N, 2008, RES DEV DISABIL, V29, P595, DOI 10.1016/j.ridd.2007.10.001
   Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   POSNER MI, 1980, Q J EXP PSYCHOL, V32, P3, DOI 10.1080/00335558008248231
   Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
   Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1958, DOI 10.1007/s10803-008-0592-4
   Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x
   Swettenham J, 2003, PHILOS T R SOC B, V358, P325, DOI 10.1098/rstb.2002.1203
   Tipples J, 2002, PSYCHON B REV, V9, P314, DOI 10.3758/BF03196287
   Vlamings PHJM, 2005, J AUTISM DEV DISORD, V35, P267, DOI 10.1007/s10803-005-3289-y
   Zhao S, 2013, RES AUTISM SPECT DIS, V7, P1250, DOI 10.1016/j.rasd.2013.07.001
NR 31
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-6918
EI 1873-6297
J9 ACTA PSYCHOL
JI Acta Psychol.
PD JUL
PY 2014
VL 150
BP 100
EP 105
DI 10.1016/j.actpsy.2014.05.003
PG 6
WC Psychology, Experimental
SC Psychology
GA AL0IU
UT WOS:000338811400013
PM 24866453
ER

PT J
AU Biscaldi, M
   Rauh, R
   Irion, L
   Jung, NH
   Mall, V
   Fleischhaker, C
   Klein, C
AF Biscaldi, Monica
   Rauh, Reinhold
   Irion, Lisa
   Jung, Nikolai H.
   Mall, Volker
   Fleischhaker, Christian
   Klein, Christoph
TI Deficits in motor abilities and developmental fractionation of imitation
   performance in high-functioning autism spectrum disorders
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders; Neuromotor deficit; Zurich Neuromotor
   Assessment; Imitation; Non-meaningful gestures
ID MIRROR NEURON SYSTEM; ASPERGER-SYNDROME; NEUROMOTOR DEVELOPMENT;
   DIAGNOSTIC INTERVIEW; GERMAN FORM; CHILDREN; RELIABILITY; DYSFUNCTION;
   IMPAIRMENT; CEREBELLUM
AB The co-occurrence of motor and imitation disabilities often characterises the spectrum of deficits seen in patients with autism spectrum disorders (ASD). Whether these seemingly separate deficits are inter-related and whether, in particular, motor deficits contribute to the expression of imitation deficits is the topic of the present study and was investigated by comparing these deficits' cross-sectional developmental trajectories. To that end, different components of motor performance assessed in the Zurich Neuromotor Assessment and imitation abilities for facial movements and non-meaningful gestures were tested in 70 subjects (aged 6-29 years), including 36 patients with high-functioning ASD and 34 age-matched typically developed (TD) participants. The results show robust deficits in probands with ASD in timed motor performance and in the quality of movement, which are all independent of age, with one exception. Only diadochokinesis improves moderately with increasing age in ASD probands. Imitation of facial movements and of non-meaningful hand, finger, hand finger gestures not related to social context or tool use is also impaired in ASD subjects, but in contrast to motor performance this deficit overall improves with age. A general imitation factor, extracted from the highly inter-correlated imitation tests, is differentially correlated with components of neuromotor performance in ASD and TD participants. By developmentally fractionating developmentally stable motor deficits from developmentally dynamic imitation deficits, we infer that imitation deficits are primarily cognitive in nature.
C1 [Biscaldi, Monica; Rauh, Reinhold; Irion, Lisa; Fleischhaker, Christian; Klein, Christoph] Univ Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-79104 Freiburg, Germany.
   [Jung, Nikolai H.; Mall, Volker] Tech Univ Munich, Dept Paediat, D-80290 Munich, Germany.
   [Klein, Christoph] Bangor Univ, Sch Psychol, Bangor, Gwynedd, Wales.
RP Biscaldi, M (reprint author), Univ Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, Hauptstr 8, D-79104 Freiburg, Germany.
EM monica.biscaldi-schaefer@uniklinik-freiburg.de
CR Ahsgren I, 2005, DEV MED CHILD NEUROL, V47, P193, DOI 10.1017/S0012162205000356
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019
   Bizzozero I, 2000, BRAIN, V123, P2213, DOI 10.1093/brain/123.11.2213
   Bolte S, 2004, Z KINDER JUG-PSYCH, V32, P45, DOI 10.1024/1422-4917.32.1.45
   Cortina J. M., 2000, EFFECT SIZE ANOVA DE
   Cossu G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044779
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   Courchesne E, 2005, DEV PSYCHOPATHOL, V17, P577, DOI 10.1017/S0954579405050285
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   DIPELLEGRINO G, 1992, EXP BRAIN RES, V91, P176
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Enticott PG, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00218
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Freitag CM, 2006, EUR CHILD ADOLES PSY, V15, P282, DOI 10.1007/s00787-006-0533-8
   Freitag CM, 2007, J AUTISM DEV DISORD, V37, P948, DOI 10.1007/s10803-006-0235-6
   Frith C, 2005, CURR BIOL, V15, pR644, DOI 10.1016/j.cub.2005.08.041
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
   Gillberg Christopher, 2003, Neural Plasticity, V10, P59, DOI 10.1155/NP.2003.59
   Goldenberg G, 1996, J NEUROL NEUROSUR PS, V61, P176, DOI 10.1136/jnnp.61.2.176
   Gowen E, 2005, CEREBELLUM, V4, P279, DOI 10.1080/14734220500355332
   Gowen E, 2007, CEREBELLUM, V6, P268, DOI 10.1080/14734220601184821
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   Ham HS, 2011, J AUTISM DEV DISORD, V41, P1, DOI 10.1007/s10803-010-1011-1
   Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hedges L, 1985, STAT METHODS METAANA
   Hill EL, 2003, PHILOS T R SOC B, V358, P281, DOI 10.1098/rstb.2002.1209
   Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
   Jongmans MJ, 2011, DEV MED CHILD NEUROL, V52, P174
   Kaufman J, 2001, KIDDIE SADS PRESENT
   Klein C, 2005, DEV BRAIN RES, V160, P113, DOI 10.1016/j.devbrainres.2005.06.011
   Klein C, 2003, PSYCHOPHYSIOLOGY, V40, P1
   Klein C, 2005, EXP BRAIN RES, V165, P132, DOI 10.1007/s00221-005-2324-8
   Klein C, 2001, EXP BRAIN RES, V139, P1
   Klein C, 2011, EXP BRAIN RES, V210, P33, DOI 10.1007/s00221-011-2601-7
   Klein C, 2007, J CLIN EXP NEUROPSYC, V29, P25, DOI 10.1080/13803390500276859
   Largo RH, 2007, ZURCHER NEUROMOTORIK
   Largo RH, 2001, DEV MED CHILD NEUROL, V43, P436, DOI 10.1017/S0012162201000810
   Largo RH, 2001, DEV MED CHILD NEUROL, V43, P444, DOI 10.1017/S0012162201000822
   Lepage JF, 2007, DEVELOPMENTAL SCI, V10, P513, DOI 10.1111/j.1467-7687.2007.00631.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luna B, 2008, BRAIN COGNITION, V68, P293, DOI 10.1016/j.bandc.2008.08.019
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
   Minshew NJ, 2002, MOL PSYCHIATR S2, V7, P14
   Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437
   Mostofsky SH, 2007, BRAIN, V130, P2117, DOI 10.1093/brain/awm129
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Nayate A, 2005, BRAIN RES BULL, V67, P327, DOI 10.1016/j.brainresbull.2005.07.011
   Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Petermann F, 2008, HAMBURG WECHSLER INT
   Poustka F, 1996, PSYCHOPATHOLOGY, V29, P145
   Press C, 2010, NEUROPSYCHOLOGIA, V48, P3291, DOI 10.1016/j.neuropsychologia.2010.07.012
   Raven J., 2003, MANUAL RAVENS PROGRE
   Rizzolatti G, 2009, NAT CLIN PRACT NEURO, V5, P24, DOI 10.1038/ncpneuro0990
   Rousson V, 2008, CLIN NEUROPSYCHOL, V22, P60, DOI 10.1080/13854040601076702
   Sevlever M, 2010, RES DEV DISABIL, V31, P976, DOI 10.1016/j.ridd.2010.04.014
   Staples KL, 2010, J AUTISM DEV DISORD, V40, P209, DOI 10.1007/s10803-009-0854-9
   Tewes U., 1999, HAMBURG WECHSLER INT
   Vanvuchelen M, 2011, RES AUTISM SPECT DIS, V5, P89, DOI 10.1016/j.rasd.2010.07.010
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
NR 67
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
EI 1435-165X
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD JUL
PY 2014
VL 23
IS 7
BP 599
EP 610
DI 10.1007/s00787-013-0475-x
PG 12
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA AK9QG
UT WOS:000338761100010
PM 24085467
ER

PT J
AU Saunders, C
   Siuta, M
   Robertson, SD
   Davis, AR
   Sauer, J
   Matthies, HJG
   Gresch, PJ
   Airey, DC
   Lindsley, CW
   Schetz, JA
   Niswender, KD
   Veenstra-Vanderweele, JM
   Galli, A
AF Saunders, Christine
   Siuta, Michael
   Robertson, Sabrina D.
   Davis, Adeola R.
   Sauer, Jennifer
   Matthies, Heinrich J. G.
   Gresch, Paul J.
   Airey, David C.
   Lindsley, Craig W.
   Schetz, John A.
   Niswender, Kevin D.
   Veenstra-Vanderweele, Jeremy M.
   Galli, Aurelio
TI Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor
   function
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE Serotonin; Akt; Cortex; 5HT(1A) receptor; 5HT(2A) receptor
ID SEROTONIN 2A RECEPTOR; NOREPINEPHRINE TRANSPORTER TRAFFICKING;
   POSITRON-EMISSION-TOMOGRAPHY; HEAD-TWITCH RESPONSE; DOPAMINE
   TRANSPORTER; IN-VIVO; RAT-BRAIN; BINDING; 5-HT2A; MICE
AB The serotonergic system regulates a wide range of behavior, including mood and impulsivity, and its dysregulation has been associated with mood disorders, autism spectrum disorder, and addiction. Diabetes is a risk factor for these conditions. Insulin resistance in the brain is specifically associated with susceptibility to psychostimulant abuse. Here, we examined whether phosphorylation of Akt, a key regulator of the insulin signaling pathway, controls serotonin (5-HT) signaling. To explore how impairment in Akt function regulates 5-HT homeostasis, we used a brain-specific rictor knockout (KO) mouse model of impaired neuronal phosphorylation of Akt at Ser473. Cortical 5-HT1A and 5-HT2A receptor binding was significantly elevated in rictor KO mice. Concomitant with this elevated receptor expression, the 5-HT1A receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) led to an increased hypothermic response in rictor KO mice. The increased cortical 5-HT1A receptor density was associated with higher 5-HT1A receptor levels on the cortical cell surface. In contrast, rictor KO mice displayed significantly reduced head-twitch response (HTR) to the 5-HT2A/C agonist 2,5-dimethoxy-4-iodamphetamine (DOI), with evidence of impaired 5-HT2A/C receptor signaling. In vitro, pharmacological inhibition of Akt significantly increased 5-HT1A receptor expression and attenuated DOI-induced 5-HT2A receptor signaling, thereby lending credence to the observed in vivo cross-talk between neuronal Akt signaling and 5-HT receptor regulation. These data reveal that defective central Akt function alters 5-HT signaling as well as 5-HT-associated behaviors, demonstrating a novel role for Akt in maintaining neuronal 5-HT receptor function. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Saunders, Christine; Gresch, Paul J.; Airey, David C.; Lindsley, Craig W.; Veenstra-Vanderweele, Jeremy M.] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.
   [Siuta, Michael; Robertson, Sabrina D.; Davis, Adeola R.; Matthies, Heinrich J. G.; Galli, Aurelio] Vanderbilt Univ, Med Ctr, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
   [Sauer, Jennifer; Veenstra-Vanderweele, Jeremy M.] Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN 37232 USA.
   [Niswender, Kevin D.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA.
   [Galli, Aurelio] Vanderbilt Univ, Med Ctr, Dept Neurosci, Program Subst Abuse, Nashville, TN 37232 USA.
   [Schetz, John A.] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA.
RP Veenstra-Vanderweele, JM (reprint author), Vanderbilt Univ, Med Ctr, Dept Psychiat, 465 21st Ave South,MRB3,Room 7158C, Nashville, TN 37232 USA.
EM j.vvw@vanderbilt.edu; aurelio.-galli@vanderbilt.edu
FU National Institutes of Health [P50 MH078028, MH063162, MH081066,
   DK085712]
FX This work was supported by National Institutes of Health Grants P50
   MH078028-Pilot Project (C.S.), MH063162 (J.A.S.), MH081066 (J.V.), and
   DK085712 (A.G. and K.D.N.). We thank Amanda Poe for assistance in
   genotyping and maintaining the mouse colonies. We are very grateful to
   the Conte Center Bioanalytical Core, specifically to Brett Begely, for
   his technical skills with the 5-HT receptor and transporter binding
   studies.
CR Abbas A, 2008, P NATL ACAD SCI USA, V105, P831, DOI 10.1073/pnas.0711335105
   Abbas AI, 2009, J NEUROSCI, V29, P7124, DOI 10.1523/JNEUROSCI.1090-09.2009
   Arapulisamy O, 2013, J BIOL CHEM, V288, P28599, DOI 10.1074/jbc.M113.472878
   Bailer UF, 2013, PSYCHIAT RES-NEUROIM, V211, P160, DOI 10.1016/j.pscychresns.2012.06.010
   Beaulieu JM, 2009, ANNU REV PHARMACOL, V49, P327, DOI 10.1146/annurev.pharmtox.011008.145634
   Berger M, 2009, ANNU REV MED, V60, P355, DOI 10.1146/annurev.med.60.042307.110802
   Bert B, 2006, BEHAV BRAIN RES, V167, P328, DOI 10.1016/j.bbr.2005.09.020
   Bertolino A, 2009, J NEUROSCI, V29, P1224, DOI 10.1523/JNEUROSCI.4858-08.2009
   Bhattacharyya S, 2006, P NATL ACAD SCI USA, V103, P15248, DOI 10.1073/pnas.0606578103
   BILL DJ, 1991, BRIT J PHARMACOL, V103, P1857
   Canal CE, 2010, PSYCHOPHARMACOLOGY, V209, P163, DOI 10.1007/s00213-010-1784-0
   Chang CW, 2009, NEUROPHARMACOLOGY, V56, P213, DOI 10.1016/j.neuropharm.2008.07.049
   Chen XN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032511
   Cummings DF, 2010, BIOORGAN MED CHEM, V18, P4783, DOI 10.1016/j.bmc.2010.05.017
   DARMANI NA, 1991, PHARMACOL BIOCHEM BE, V38, P353, DOI 10.1016/0091-3057(91)90290-I
   Daws LC, 2011, NEUROPHARMACOLOGY, V61, P1123, DOI 10.1016/j.neuropharm.2011.02.028
   El Yacoubi M, 2003, P NATL ACAD SCI USA, V100, P6227, DOI 10.1073/pnas.1034823100
   EMERIT MB, 1990, BIOCHEM PHARMACOL, V39, P7, DOI 10.1016/0006-2952(90)90642-X
   Fox MA, 2010, BRIT J PHARMACOL, V159, P879, DOI 10.1111/j.1476-5381.2009.00578.x
   Garcia BG, 2005, MOL PHARMACOL, V68, P102, DOI 10.1124/mol.104.009092
   Gingrich JA, 2001, PSYCHOPHARMACOLOGY, V155, P1, DOI 10.1007/s002130000573
   Gonzalez-Maeso J, 2007, NEURON, V53, P439, DOI 10.1016/j.neuron.2007.01.008
   HALL MD, 1985, J NEUROCHEM, V44, P1685, DOI 10.1111/j.1471-4159.1985.tb07155.x
   Heisler LK, 1998, P NATL ACAD SCI USA, V95, P15049, DOI 10.1073/pnas.95.25.15049
   Ikeda M, 2006, INT J NEUROPSYCHOPH, V9, P77, DOI 10.1017/S1461145705005481
   Jans LAW, 2007, MOL PSYCHIATR, V12, P522, DOI 10.1038/sj.mp.4001920
   Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
   Lam Daniel D, 2007, Expert Rev Mol Med, V9, P1
   Lan MY, 2009, J ENDOCRINOL INVEST, V32, P119
   Li JX, 2008, BEHAV PHARMACOL, V19, P292, DOI 10.1097/FBP.0b013e328308f1d6
   Li XH, 2004, NEUROPSYCHOPHARMACOL, V29, P1426, DOI 10.1038/sj.npp.1300439
   Lindsley CW, 2005, BIOORG MED CHEM LETT, V15, P761, DOI 10.1016/j.bmcl.2004.11.011
   Lustman PJ, 2005, J DIABETES COMPLICAT, V19, P113, DOI 10.1016/j.jdiacomp.2004.01.002
   Lyall K, 2012, AUTISM RES, V5, P21, DOI 10.1002/aur.228
   Nomura Y, 2012, ARCH PEDIAT ADOL MED, V166, P337, DOI 10.1001/archpediatrics.2011.784
   Matthies HJG, 2010, J NEUROSCI, V30, P7863, DOI 10.1523/JNEUROSCI.4574-09.2010
   Miyata S, 2004, PSYCHOPHARMACOLOGY, V177, P224, DOI 10.1007/s00213-004-1942-3
   MONGEAU R, 1992, BRAIN RES, V590, P229, DOI 10.1016/0006-8993(92)91100-S
   Morecroft I, 2005, J PHARMACOL EXP THER, V313, P539, DOI 10.1124/jpet.104.081182
   Nash JR, 2008, BRIT J PSYCHIAT, V193, P229, DOI 10.1192/bjp.bp.107.041186
   NENONENE EK, 1994, J NEUROCHEM, V62, P1822
   Nichols DE, 2004, PHARMACOL THERAPEUT, V101, P131, DOI 10.1016/j.pharmthera.2003.11.002
   Nicodemus KK, 2010, ARCH GEN PSYCHIAT, V67, P991, DOI 10.1001/archgenpsychiatry.2010.117
   Niswender KD, 2011, NEUROPSYCHOPHARMACOL, V36, P359, DOI 10.1038/npp.2010.167
   Nonogaki K, 1998, NAT MED, V4, P1152, DOI 10.1038/2647
   Oz M, 2003, SYNAPSE, V50, P303, DOI 10.1002/syn.10273
   Papazoglou I, 2012, MOL CELL ENDOCRINOL, V350, P136, DOI 10.1016/j.mce.2011.12.007
   Park S, 1999, BRAIN RES, V847, P90, DOI 10.1016/S0006-8993(99)02055-7
   Price JC, 2002, BRAIN RES, V927, P97, DOI 10.1016/S0006-8993(01)03297-8
   Ramboz S, 1998, P NATL ACAD SCI USA, V95, P14476, DOI 10.1073/pnas.95.24.14476
   Richardson-Jones JW, 2010, NEURON, V65, P40, DOI 10.1016/j.neuron.2009.12.003
   Richardson-Jones JW, 2011, J NEUROSCI, V31, P6008, DOI 10.1523/JNEUROSCI.5836-10.2011
   Robertson SD, 2010, J NEUROSCI, V30, P11305, DOI 10.1523/JNEUROSCI.0126-10.2010
   Rusyniak DE, 2007, J PHARMACOL EXP THER, V323, P477, DOI 10.1124/jpet.107.126169
   Sarbassov DD, 2005, SCIENCE, V307, P1098, DOI 10.1126/science.1106148
   Schmid CL, 2008, P NATL ACAD SCI USA, V105, P1079, DOI 10.1073/pnas.0708862105
   Schmid CL, 2010, J NEUROSCI, V30, P13513, DOI 10.1523/JNEUROSCI.1665-10.2010
   Schoffelmeer ANM, 2000, J NEUROSCI, V20, P3496
   Schulze DR, 2012, PSYCHOPHARMACOLOGY, V222, P425, DOI 10.1007/s00213-012-2661-9
   Siuta MA, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000393
   Speed N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025169
   Speed NK, 2010, ACS CHEM NEUROSCI, V1, P476, DOI [10.1021/cn100031t, 10.1021/cn1000311]
   Sumiyoshi T, 1997, NEUROPSYCHOPHARMACOL, V16, P183, DOI 10.1016/S0893-133X(96)00185-6
   Thiselton DL, 2008, BIOL PSYCHIAT, V63, P449, DOI 10.1016/j.biopsych.2007.06.005
   Toperoff G, 2012, HUM MOL GENET, V21, P371, DOI 10.1093/hmg/ddr472
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   Watts SW, 1996, J PHARMACOL EXP THER, V279, P1541
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Williams Jason M, 2007, PLoS Biol, V5, pe274, DOI 10.1371/journal.pbio.0050274
   WOZNIAK KM, 1991, EUR J PHARMACOL, V193, P253, DOI 10.1016/0014-2999(91)90044-Q
   Yamada J, 1999, EUR J PHARMACOL, V382, P211, DOI 10.1016/S0014-2999(99)00593-2
   Zhao J., 2012, INT J OBES LOND, V37, P140
   Zhu CB, 2011, MOL PHARMACOL, V80, P458, DOI 10.1124/mol.111.071399
NR 73
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD JUL
PY 2014
VL 73
SI SI
BP 113
EP 121
DI 10.1016/j.neuint.2013.09.015
PG 9
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AL0FW
UT WOS:000338803800013
PM 24090638
ER

PT J
AU Whyte, A
   Jessen, T
   Varney, S
   Carneiro, AMD
AF Whyte, Alonzo
   Jessen, Tammy
   Varney, Seth
   Carneiro, Ana M. D.
TI Serotonin transporter and integrin beta 3 genes interact to modulate
   serotonin uptake in mouse brain
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE Serotonin transporter; Integrin; Genetic interaction; Neuropsychiatric
   disorders; Autism
ID MICE; DEPRESSION; RECEPTOR
AB Dysfunctions in serotonin (5-hydroxytryptamine, 5-HT) systems have been associated with several psychiatric illnesses, including anxiety, depression, obsessive-compulsive disorders and autism spectrum disorders. Convergent evidence from genetic analyses of human subjects has implicated the integrin beta 3 subunit gene (ITGB3) as a modulator of serotonergic systems via genetic interactions with the 5-HT transporter gene (SLC6A4, SERT). While genetic interactions may result from contributions of each gene at several levels, we hypothesize that ITGB3 modulates the 5-HT system at the level of the synapse, through the actions of integrin alpha v beta 3. Here we utilized a genetic approach in mouse models to examine Itgb3 contributions to SERT function both in the context of normal and reduced SERT expression. As integrin alpha v beta 3 is expressed in postsynaptic membranes, we isolated synaptoneurosomes, which maintain intact pre- and post-synaptic associations. Citalopram binding revealed significant Slc6a4-driven reductions in SERT expression in midbrain synapses, whereas no significant changes were observed in hippocampal or cortical projections. Expecting corresponding changes to SERT function, we also measured 5-HT uptake activity in synaptoneurosomal preparations. Itgb3 single heterozygous mice displayed significant reductions in 5-HT V-max, with no changes in K in midbrain preparations. However, in the presence of both Itgb3 and Slc6a4 heterozygozity, 5-HT uptake was similar to wild-type levels, revealing a significant Slc6a4 by Itgb3 genetic interaction in the midbrain. Similar findings were observed in cortical preparations, whereas in the hippocampus, most V-max changes were driven solely by Slc6a4. Our findings provide evidence that integrin alpha v beta 3 is involved in the regulation of serotonergic systems in some, but not all 5-HT synapses, revealing novel contributions to synaptic specificity within the central nervous system. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Whyte, Alonzo] Vanderbilt Brain Inst, Neurosci Grad Program, Nashville, TN 37232 USA.
   [Jessen, Tammy; Varney, Seth; Carneiro, Ana M. D.] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA.
RP Carneiro, AMD (reprint author), Vanderbilt Univ, Med Ctr, 461 Preston Res Bldg,23rd Ave South Pierce, Nashville, TN 37232 USA.
EM ana.carneiro@vanderbilt.edu
FU NIMH [090256-01A1]
FX We thank Dennis Murphy and Richard Hynes for generating the Slc6a4 and
   Itgb3 lines used in this paper. We thank Jeremy Veenstra-Vanderweele and
   Randy D. Blakely for many helpful discussions. This work was supported
   by NIMH Grant 090256-01A1.
CR Bengel D, 1998, MOL PHARMACOL, V53, P649
   Bengel D, 1997, BRAIN RES, V778, P338, DOI 10.1016/S0006-8993(97)01080-9
   Carneiro AMD, 2008, J CLIN INVEST, V118, P1544, DOI 10.1172/JCI33374
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Cingolani LA, 2008, NEURON, V58, P749, DOI 10.1016/j.neuron.2008.04.011
   Hodivala-Dilke KM, 1999, J CLIN INVEST, V103, P229, DOI 10.1172/JCI5487
   Murphy DL, 2011, CURR OPIN PHARMACOL, V11, P3, DOI 10.1016/j.coph.2011.02.008
   Phillips GR, 2001, NEURON, V32, P63, DOI 10.1016/S0896-6273(01)00450-0
   Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
   Tao-Cheng JH, 1999, NEUROSCIENCE, V94, P821, DOI 10.1016/S0306-4522(99)00373-5
   Udo H, 2005, NEURON, V45, P887, DOI 10.1016/j.neuron.2005.01.044
   Velayudhan A, 1999, BIOL PSYCHIAT, V45, P1059, DOI 10.1016/S0006-3223(98)00239-X
   Wang XB, 2008, P NATL ACAD SCI USA, V105, P19520, DOI 10.1073/pnas.0807248105
   Weiss LA, 2004, EUR J HUM GENET, V12, P949, DOI 10.1038/sj.ejhg.5201239
   Willeit M, 2008, NEUROPSYCHOPHARMACOL, V33, P1503, DOI 10.1038/sj.npp.1301560
NR 15
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD JUL
PY 2014
VL 73
SI SI
BP 122
EP 126
DI 10.1016/j.neuint.2013.09.014
PG 5
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AL0FW
UT WOS:000338803800014
PM 24083985
ER

PT J
AU Ilie, A
   Weinstein, E
   Boucher, A
   McKinney, RA
   Orlowski, J
AF Ilie, Alina
   Weinstein, Erica
   Boucher, Annie
   McKinney, R. Anne
   Orlowski, John
TI Impaired posttranslational processing and trafficking of an endosomal
   Na+/H+ exchanger NHE6 mutant (Delta(WST372)-W-370) associated with
   X-linked intellectual disability and autism
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE NHE6; Recycling endosomes; Vesicular trafficking; Neurodegeneration;
   Intellectual disability
ID ENDOPLASMIC-RETICULUM STRESS; HIPPOCAMPAL PYRAMIDAL NEURONS;
   GLYCOGEN-SYNTHASE KINASE-3; MENTAL-RETARDATION; DENDRITIC SPINES;
   CHRISTIANSON SYNDROME; RECYCLING ENDOSOMES; ANGELMAN-SYNDROME; SLC9A6
   MUTATIONS; AMPA RECEPTORS
AB Ne+/H+ exchanger NHE6/SLC9A6 is an X-linked gene that is widely expressed and especially abundant in brain, heart and skeletal muscle where it is implicated in endosomal pH homeostasis and trafficking as well as maintenance of cell polarity. Recent genetic studies have identified several mutations in the coding region of NHE6 that are linked with severe intellectual disability, autistic behavior, ataxia and other abnormalities. One such defect consists of an in-frame deletion of three amino acids ((370)Trp-Ser-Thr(372), Delta WST) that adjoin the predicted ninth transmembrane helix of the exchanger. To better understand the nature of this mutation, a NHE6 Delta WST construct was generated and assessed for its effects on the biochemical and cellular properties of the transporter. In transfected fibroblastic CHO and neuroblastoma SH-SY5Y cells, immunoblot analyses showed that the mutant protein was effectively synthesized, but its subsequent oligosaccharide maturation and overall half-life were dramatically reduced compared to wild-type. These changes correlated with significant accumulation of AWST in the endoplasmic reticulum, with only minor sorting to the plasma membrane and negligible trafficking to recycling endosomes. The diminished accumulation in recycling endosomes was associated with a significant decrease in the rate of endocytosis of cell surface AWST compared to wild-type. Furthermore, while ectopic expression of wild-type NHE6 enhanced the uptake of other vesicular cargo such as transferrin along the clathrin-mediated recycling endosomal pathway, this ability was lost in the AWST mutant. Similarly, in transfected primary mouse hippocampal neurons, wild-type NHE6 was localized in discrete puncta throughout the soma and neurites, whereas the AWST mutant displayed a diffuse reticular pattern. Remarkably, the extensive dendritic arborization observed in neurons expressing wild-type NHE6 was noticeably diminished in Delta WST-transfectants. These results suggest that deletion of (370)Trp-Ser-Thr(372) leads to endoplasmic reticulum retention and loss of NHE6 function which potentially impacts the trafficking of other membrane-bound cargo and cell polarity. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Ilie, Alina; Weinstein, Erica; Boucher, Annie; Orlowski, John] McGill Univ, Dept Physiol, Montreal, PQ H3G 0B1, Canada.
   [McKinney, R. Anne] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 0B1, Canada.
RP Orlowski, J (reprint author), McGill Univ, Dept Physiol, McIntyre Med Sci Bldg, Montreal, PQ H3G 0B1, Canada.
EM john.orlowski@mcgill.ca
FU Canadian Institutes of Health [MOP-86724, MOP-111191]
FX We thank Mica Das Gupta and Cassandra McEwan for technical assistance.
   We also acknowledge the technical assistance provided by the McGill Life
   Sciences Imaging Facility and Genome Quebec. This work was supported by
   Canadian Institutes of Health Research funding held by R.A.M.
   (MOP-86724) and J.O. (MOP-111191).
CR Barriere H, 2011, METHODS MOL BIOL, V741, P301, DOI 10.1007/978-1-61779-117-8_20
   Blanpied TA, 2002, NEURON, V36, P435, DOI 10.1016/S0896-6273(02)00979-0
   Brett CL, 2002, AM J PHYSIOL-CELL PH, V282, pC1031, DOI 10.1152/ajpcell.00420.2001
   Christianson AL, 1999, J MED GENET, V36, P759
   Cooney JR, 2002, J NEUROSCI, V22, P2215
   Deane EC, 2013, J NEUROSCI, V33, P595, DOI 10.1523/JNEUROSCI.2583-12.2013
   DORNER AJ, 1987, J CELL BIOL, V105, P2665, DOI 10.1083/jcb.105.6.2665
   Doyle KM, 2011, J CELL MOL MED, V15, P2025, DOI 10.1111/j.1582-4934.2011.01374.x
   Garbern JY, 2010, BRAIN, V133, P1391, DOI 10.1093/brain/awq071
   Gecz J, 2009, TRENDS GENET, V25, P308, DOI 10.1016/j.tig.2009.05.002
   Gilfillan GD, 2008, AM J HUM GENET, V82, P1003, DOI 10.1016/j.ajhg.2008.01.013
   Humeau Y, 2009, J NEUROCHEM, V109, P1, DOI 10.1111/j.1471-4159.2009.05881.x
   Inlow JK, 2004, GENETICS, V166, P835, DOI 10.1534/genetics.166.2.835
   Jiang M, 2006, NAT PROTOC, V1, P695, DOI 10.1038/nprot.2006.86
   Jope RS, 2004, TRENDS BIOCHEM SCI, V29, P95, DOI 10.1016/j.tibs.2003.12.004
   Kazazic M, 2009, TRAFFIC, V10, P235, DOI 10.1111/j.1600-0854.2008.00858.x
   Kennedy MJ, 2010, CELL, V141, P524, DOI 10.1016/j.cell.2010.02.042
   Kim AJ, 2005, J CELL SCI, V118, P89, DOI 10.1242/jcs.01562
   LEBIVIC A, 1989, P NATL ACAD SCI USA, V86, P9313
   Lein ES, 2004, J NEUROSCI, V24, P3879, DOI 10.1523/JNEUROSCI.4710-03.2004
   Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031
   Lubs HA, 2012, AM J HUM GENET, V90, P579, DOI 10.1016/j.ajhg.2012.02.018
   Marciniak SJ, 2006, PHYSIOL REV, V86, P1133, DOI 10.1152/physrev.00015.2006
   MELLMAN I, 1992, J EXP BIOL, V172, P39
   Mignot C, 2013, BRAIN DEV-JPN, V35, P172, DOI 10.1016/j.braindev.2012.03.010
   Mitra N, 2006, TRENDS BIOCHEM SCI, V31, P156, DOI 10.1016/j.tibs.2006.01.003
   Miyazaki E, 2001, J BIOL CHEM, V276, P49221, DOI 10.1074/jbc.M106267200
   MONTESANO R, 1982, NATURE, V296, P651, DOI 10.1038/296651a0
   Morris M, 2011, NEURON, V70, P410, DOI 10.1016/j.neuron.2011.04.009
   Orlowski J, 2011, COMPR PHYSIOL, V1, P2083, DOI 10.1002/cphy.c110020
   Orlowski J, 2007, CURR OPIN CELL BIOL, V19, P483, DOI 10.1016/j.ceb.2007.06.001
   Park M, 2006, NEURON, V52, P817, DOI 10.1016/j.neuron.2006.09.040
   Park M, 2004, SCIENCE, V305, P1972, DOI 10.1126/science.1102026
   Petrini EM, 2009, NEURON, V63, P92, DOI 10.1016/j.neuron.2009.05.025
   Racz B, 2004, NAT NEUROSCI, V7, P917, DOI 10.1038/nn1303
   Reynolds CH, 1997, J NEUROCHEM, V68, P1736
   Riess A, 2013, CLIN GENET, V83, P596, DOI 10.1111/j.1399-0004.2012.01948.x
   Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
   ROTIN D, 1989, AM J PHYSIOL, V257, pC1158
   Roussel BD, 2013, LANCET NEUROL, V12, P105, DOI 10.1016/S1474-4422(12)70238-7
   Roxrud I, 2009, EXP CELL RES, V315, P3014, DOI 10.1016/j.yexcr.2009.07.012
   Ruddock LW, 2006, J CELL SCI, V119, P4373, DOI 10.1242/jcs.03225
   Schroer RJ, 2010, AM J MED GENET A, V152A, P2775, DOI 10.1002/ajmg.a.33093
   Shi SH, 2001, CELL, V105, P331, DOI 10.1016/S0092-8674(01)00321-X
   Stromme P, 2011, BRAIN, V134, P3369, DOI 10.1093/brain/awr250
   Tabas I, 2011, NAT CELL BIOL, V13, P184, DOI 10.1038/ncb0311-184
   Takahashi Y, 2011, AM J MED GENET B, V156B, P799, DOI 10.1002/ajmg.b.31221
   Tzschach A, 2011, AM J MED GENET A, V155A, P2771, DOI 10.1002/ajmg.a.34230
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Vaillend C, 2008, BEHAV BRAIN RES, V192, P88, DOI 10.1016/j.bbr.2008.01.009
   Ohgaki R, 2010, MOL BIOL CELL, V21, P1293, DOI 10.1091/mbc.E09-09-0767
   Viana RJS, 2012, MOL NEUROBIOL, V46, P522, DOI 10.1007/s12035-012-8301-x
   Vogel J, 2009, NEUROPHARMACOLOGY, V57, P539, DOI 10.1016/j.neuropharm.2009.07.021
   Weisz OA, 2003, INT REV CYTOL, V226, P259, DOI 10.1016/S0074-7696(03)01005-2
   Xinhan Lou, 2011, Am J Physiol Cell Physiol, V301, pC1431, DOI 10.1152/ajpcell.00154.2011
   Yuste R, 2001, ANNU REV NEUROSCI, V24, P1071, DOI 10.1146/annurev.neuro.24.1.1071
NR 56
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD JUL
PY 2014
VL 73
SI SI
BP 192
EP 203
DI 10.1016/j.neuint.2013.09.020
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AL0FW
UT WOS:000338803800024
PM 24090639
ER

PT J
AU Duerden, EG
   Card, D
   Roberts, SW
   Mak-Fan, KM
   Chakravarty, MM
   Lerch, JP
   Taylor, MJ
AF Duerden, Emma G.
   Card, Dallas
   Roberts, S. Wendy
   Mak-Fan, Kathleen M.
   Chakravarty, M. Mallar
   Lerch, Jason P.
   Taylor, Margot J.
TI Self-injurious behaviours are associated with alterations in the
   somatosensory system in children with autism spectrum disorder
SO BRAIN STRUCTURE & FUNCTION
LA English
DT Article
DE Autism; Spectrum disorder; Injury; Grey matter; White matter; Pain
ID REDUCED THALAMIC VOLUME; CORTICAL THICKNESS; REPETITIVE BEHAVIOR;
   WARPING TECHNIQUES; BRAIN OVERGROWTH; MATTER STRUCTURE; PARIETAL LOBE;
   RISK-FACTORS; MRI DATA; DIFFUSION
AB Children with autism spectrum disorder (ASD) frequently engage in self-injurious behaviours, often in the absence of reporting pain. Previous research suggests that altered pain sensitivity and repeated exposure to noxious stimuli are associated with morphological changes in somatosensory and limbic cortices. Further evidence from postmortem studies with self-injurious adults has indicated alterations in the structure and organization of the temporal lobes; however, the effect of self-injurious behaviour on cortical development in children with ASD has not yet been determined. Thirty children and adolescents (mean age = 10.6 +/- A 2.5 years; range 7-15 years; 29 males) with a clinical diagnosis of ASD and 30 typically developing children (N = 30, mean age = 10.7 +/- A 2.5 years; range 7-15 years, 26 males) underwent T1-weighted magnetic resonance and diffusion tensor imaging. No between-group differences were seen in cerebral volume, surface area or cortical thickness. Within the ASD group, self-injury scores negatively correlated with thickness in the right superior parietal lobule t = 6.3, p < 0.0001, bilateral primary somatosensory cortices (SI) (right: t = 4.4, p = 0.02; left: t = 4.48, p = 0.004) and the volume of the left ventroposterior (VP) nucleus of the thalamus (r = -0.52, p = 0.008). Based on these findings, we performed an atlas-based region-of-interest diffusion tensor imaging analysis between SI and the VP nucleus and found that children who engaged in self-injury had significantly lower fractional anisotropy (r = -0.4, p = 0.04) and higher mean diffusivity (r = 0.5, p = 0.03) values in the territory of the left posterior limb of the internal capsule. Additionally, greater incidence of self-injury was associated with increased radial diffusivity values in bilateral posterior limbs of the internal capsule (left: r = 0.5, p = 0.02; right: r = 0.5, p = 0.009) and corona radiata (left: r = 0.6, p = 0.005; right: r = 0.5, p = 0.009). Results indicate that self-injury is related to alterations in somatosensory cortical and subcortical regions and their supporting white-matter pathways. Findings could reflect use-dependent plasticity in the somatosensory system or disrupted brain development that could serve as a risk marker for self-injury.
C1 [Duerden, Emma G.; Card, Dallas; Roberts, S. Wendy; Mak-Fan, Kathleen M.; Taylor, Margot J.] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1X8, Canada.
   [Duerden, Emma G.; Lerch, Jason P.; Taylor, Margot J.] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada.
   [Mak-Fan, Kathleen M.; Taylor, Margot J.] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada.
   [Chakravarty, M. Mallar] Ctr Addict & Mental Hlth, Kimel Family Translat Imaging Genet Res Lab, Res Imaging Ctr, Toronto, ON, Canada.
   [Chakravarty, M. Mallar] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Chakravarty, M. Mallar] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada.
   [Lerch, Jason P.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.
RP Duerden, EG (reprint author), Hosp Sick Children, Dept Diagnost Imaging, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM emma.duerden@sickkids.ca
FU Canadian Institutes of Health Research [MOP-81161]; Hospital for Sick
   Children; Reva Gerstein Fellowship in Paediatric Psychology
FX The authors would like to thank Wayne Lee for MRI technical and Dr.
   Annie Dupuis, Hospital for Sick Children, for statistical analysis
   support. This research was funded by the Canadian Institutes of Health
   Research [grant number MOP-81161 to MJT], Research Training Competition
   Fellowship from the Hospital for Sick Children (EGD), and a Reva
   Gerstein Fellowship in Paediatric Psychology (EGD). We also sincerely
   thank the children and their families who participated in this study.
CR Ameis SH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028044
   Armstrong D, 1999, Spec Care Dentist, V19, P72, DOI 10.1111/j.1754-4505.1999.tb01371.x
   Aylward EH, 2002, NEUROLOGY, V59, P175
   Baghdadli A, 2003, J INTELL DISABIL RES, V47, P622, DOI 10.1046/j.1365-2788.2003.00507.x
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Bodfish JW, 1999, REPETITVE BEHAV SCAL
   Boucher M, 2009, LECT NOTES COMPUT SC, V5636, P614, DOI 10.1007/978-3-642-02498-6_51
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099
   Chakravarty MM, 2009, HUM BRAIN MAPP, V30, P3574, DOI 10.1002/hbm.20780
   Chakravarty MM, 2008, MED IMAGE ANAL, V12, P713, DOI 10.1016/j.media.2008.04.003
   Chakravarty MM, 2006, NEUROIMAGE, V30, P359, DOI 10.1016/j.neuroimage.2005.09.041
   Chang LC, 2005, MAGNET RESON MED, V53, P1088, DOI 10.1002/mrm.20426
   Chung M. K., 2001, NEUROIMAGE, V13, P95, DOI 10.1016/S1053-8119(01)91438-7
   COLLINS DL, 1994, J COMPUT ASSIST TOMO, V18, P192
   Cook PA, 2006, 4 SCIENT M INT SOC M, P2759
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003
   Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020
   Delmaire C, 2007, NEUROLOGY, V69, P376, DOI 10.1212/01.wnl.0000266591.49624.1a
   Doyle-Thomas KAR, 2013, J CHILD NEUROL, V28, P729, DOI 10.1177/0883073812451496
   Duerden EG, 2012, J AUTISM DEV DISORD, V42, P2460, DOI 10.1007/s10803-012-1497-9
   Freund HJ, 2001, NEUROIMAGE, V14, pS142, DOI 10.1006/nimg.2001.0863
   Freund Hans-Joachim, 2003, Adv Neurol, V93, P179
   GAFFNEY GR, 1989, J AM ACAD CHILD PSY, V28, P534, DOI 10.1097/00004583-198907000-00011
   Grant JA, 2010, EMOTION, V10, P43, DOI 10.1037/a0018334
   Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
   Haller S, 2009, RADIOLOGY, V250, P212, DOI 10.1148/radiol.2501072153
   Hamilton LS, 2007, NEUROREPORT, V18, P1427, DOI 10.1097/WNR.0b013e3282e9a5a2
   Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
   Hardan AY, 2004, PSYCHIAT RES-NEUROIM, V131, P263, DOI 10.1016/j.pscychresns.2004.06.001
   Hardan AY, 2006, PSYCHIAT RES-NEUROIM, V147, P145, DOI 10.1016/j.pscychresns.2005.12.009
   Hardan AY, 2001, J CHILD NEUROL, V16, P421, DOI 10.1177/088307380101600607
   HILDEBRAND C, 1984, J COMP NEUROL, V224, P25, DOI 10.1002/cne.902240103
   HOF PR, 1991, ACTA NEUROPATHOL, V82, P321
   Huppi PS, 1998, PEDIATR RES, V44, P584
   Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
   KAAS JH, 1979, SCIENCE, V204, P521, DOI 10.1126/science.107591
   Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
   Lax ID, 2013, BRAIN STRUCT FUNCT, V218, P575, DOI 10.1007/s00429-012-0417-2
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Lerch JP, 2005, CEREB CORTEX, V15, P995, DOI 10.1093/cercor/bhh200
   Lipton ML, 2012, BRAIN IMAGING BEHAV, V6, P329, DOI 10.1007/s11682-012-9175-2
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lyttelton O, 2007, NEUROIMAGE, V34, P1535, DOI 10.1016/j.neuroimage.2006.10.041
   Mak-Fan KM, 2012, J AUTISM DEV DISORD, V42, P419, DOI 10.1007/s10803-011-1261-6
   Medina A C, 2003, Int J Paediatr Dent, V13, P130, DOI 10.1046/j.1365-263X.2003.00440.x
   MERZENICH MM, 1978, J COMP NEUROL, V181, P41, DOI 10.1002/cne.901810104
   Militerni R, 2002, EUR CHILD ADOLES PSY, V11, P210, DOI 10.1007/s00787-002-0279-x
   Misaki M, 2012, NEUROIMAGE, V60, P1890, DOI 10.1016/j.neuroimage.2012.01.120
   Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
   ORNITZ EM, 1974, J AUTISM CHILD SCHIZ, V4, P197, DOI 10.1007/BF02115226
   Penfield W, 1937, BRAIN, V60, P389, DOI 10.1093/brain/60.4.389
   PONS TP, 1985, J COMP NEUROL, V241, P445, DOI 10.1002/cne.902410405
   Qiu DQ, 2008, NEUROIMAGE, V41, P223, DOI 10.1016/j.neuroimage.2008.02.023
   Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
   Ross-Russell M, 2005, BRIT DENT J, V198, P473, DOI 10.1038/sj.bdj.4812250
   Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040
   Sled JG, 1998, IEEE T MED IMAGING, V17, P87, DOI 10.1109/42.668698
   Smith SM, 2004, NEUROIMAGE, V23, pS208, DOI 10.1016/j.neuroimage.2004.07.051
   Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062
   Smith SM, 2006, NEUROIMAGE, V31, P1487, DOI 10.1016/j.neuroimage.2006.02.024
   Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267
   Suzuki Y, 2003, NMR BIOMED, V16, P257, DOI 10.1002/nbm.848
   Takahashi M, 2000, RADIOLOGY, V216, P881
   Tamura R, 2010, PSYCHIAT RES-NEUROIM, V184, P186, DOI 10.1016/j.pscychresns.2010.07.001
   Teutsch S, 2008, NEUROIMAGE, V42, P845, DOI 10.1016/j.neuroimage.2008.05.044
   Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099
   Tohka J, 2004, NEUROIMAGE, V23, P84, DOI 10.1016/j.neuroimage.2004.05.007
   Tordjman S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005289
   Tsatsanis KD, 2003, BIOL PSYCHIAT, V53, P121, DOI 10.1016/S0006-3223(02)01530-5
   Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   Wolpert DM, 1998, NAT NEUROSCI, V1, P529, DOI 10.1038/2245
   Worsley KJ, 1996, HUM BRAIN MAPP, V4, P58, DOI 10.1002/(SICI)1097-0193(1996)4:1&lt;58::AID-HBM4&gt;3.0.CO;2-O
   Worsley K.J., 2009, P 15 ANN M ORG HUM B
   Zhang HQ, 2001, J NEUROPHYSIOL, V85, P1805
   Zijdenbos AP, 2002, IEEE T MED IMAGING, V21, P1280, DOI 10.1109/TMI.2002.806283
NR 81
TC 1
Z9 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-2653
EI 1863-2661
J9 BRAIN STRUCT FUNCT
JI Brain Struct. Funct.
PD JUL
PY 2014
VL 219
IS 4
BP 1251
EP 1261
DI 10.1007/s00429-013-0562-2
PG 11
WC Anatomy & Morphology; Neurosciences
SC Anatomy & Morphology; Neurosciences & Neurology
GA AK6DD
UT WOS:000338517400007
PM 23644587
ER

PT J
AU Lee, SY
   Ramirez, J
   Franco, M
   Lectez, B
   Gonzalez, M
   Barrio, R
   Mayor, U
AF Lee, So Young
   Ramirez, Juanma
   Franco, Maribel
   Lectez, Benoit
   Gonzalez, Monika
   Barrio, Rosa
   Mayor, Ugo
TI Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to
   autism, regulates protein homeostasis through the proteasomal shuttle
   Rpn10
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Article
DE Ube3a; Ubiquitin; Angelman syndrome; Autism; Proteasome; Rpn10
ID DENDRITIC SPINES; DROSOPHILA-MELANOGASTER; SYNAPSE DEVELOPMENT; GENE
   UBE3A; DEGRADATION; RECRUITMENT; EXPRESSION; MUTATIONS; COMPLEXES;
   REVEALS
AB Ubiquitination, the covalent attachment of ubiquitin to a target protein, regulates most cellular processes and is involved in several neurological disorders. In particular, Angelman syndrome and one of the most common genomic forms of autism, dup15q, are caused respectively by lack of or excess of UBE3A, a ubiquitin E3 ligase. Its Drosophila orthologue, Ube3a, is also active during brain development. We have now devised a protocol to screen for substrates of this particular ubiquitin ligase. In a neuronal cell system, we find direct ubiquitination by Ube3a of three proteasome-related proteins Rpn10, Uch-L5, and CG8209, as well as of the ribosomal protein Rps10b. Only one of these, Rpn10, is targeted for degradation upon ubiquitination by Ube3a, indicating that degradation might not be the only effect of Ube3a on its substrates. Furthermore, we report the genetic interaction in vivo between Ube3a and the C-terminal part of Rpn10. Overexpression of these proteins leads to an enhanced accumulation of ubiquitinated proteins, further supporting the biochemical evidence of interaction obtained in neuronal cells.
C1 [Lee, So Young; Ramirez, Juanma; Franco, Maribel; Lectez, Benoit; Gonzalez, Monika; Barrio, Rosa; Mayor, Ugo] CIC BioGUNE, Derio 48160, Basque Country, Spain.
   [Mayor, Ugo] Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain.
RP Mayor, U (reprint author), CIC BioGUNE, Bizkaia Teknol Pk,Bldg 801-A, Derio 48160, Basque Country, Spain.
EM umayor@cicbiogune.com
RI Barrio, Rosa/F-8712-2011
OI Barrio, Rosa/0000-0002-9663-0669
FU CIC bioGUNE Gene Silencing Platform; Basque Government [PI2011-24,
   PI2009-16, PI2012/42]; March of Dimes Basil O'Connor Starter Scholar
   Research Award [5-FY12-16]; Spanish MICINN [BFU2008-01884,
   BFU2011-25986]; Bizkaia County;  [CSD2007-008-25120]
FX We would like to thank Janice Fischer, Fen-Biao Gao, Zoltan Lipinszki,
   Bloomington Stock Center, the DRSC, and The Developmental Studies
   Hybridoma Bank-DSHB (University of Iowa) for flies, cells, dsRNA
   templates, and antibodies, and David Gubb for helpful advice and
   support. We thank J. D. Sutherland for his suggestion to use the
   anti-GFP beads. We would also like to thank Larry Reiter and Catherine
   Lindon for critical reading and comments on the manuscript. We
   acknowledge the CIC bioGUNE Gene Silencing Platform for support. This
   work was supported by a Basque Government research grant (PI2011-24) and
   a March of Dimes Basil O'Connor Starter Scholar Research Award
   (5-FY12-16) to U. M. RB thanks the Spanish MICINN (grants BFU2008-01884,
   BFU2011-25986) and the Consolider Program (CSD2007-008-25120), the
   Basque Government (PI2009-16 and PI2012/42), and the Bizkaia County.
CR Besche HC, 2009, BIOCHEMISTRY-US, V48, P2538, DOI 10.1021/bi802198q
   Bingol B, 2010, CELL, V140, P567, DOI 10.1016/j.cell.2010.01.024
   Bingol B, 2006, NATURE, V441, P1144, DOI 10.1038/nature04769
   Bowden NA, 2006, SCHIZOPHR RES, V82, P175, DOI 10.1016/j.schres.2005.11.012
   Dindot SV, 2008, HUM MOL GENET, V17, P111, DOI 10.1093/hmg/ddm288
   Franco M, 2011, MOL CELL PROTEOMICS, V10, DOI 10.1074/mcp.M110.002188
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Greer PL, 2008, NEURON, V59, P846, DOI 10.1016/j.neuron.2008.09.002
   Greer PL, 2010, CELL, V140, P704, DOI 10.1016/j.cell.2010.01.026
   Groothuis TAM, 2006, CELL DIV, V1, DOI 10.1186/1747-1028-1-21
   Hamazaki J, 2007, MOL CELL BIOL, V27, P6629, DOI 10.1128/MCB.00509-07
   Hamilton AM, 2012, NEURON, V74, P1023, DOI 10.1016/j.neuron.2012.04.031
   Hjerpe R, 2009, EMBO REP, V10, P1250, DOI 10.1038/embor.2009.192
   Hutsler JJ, 2010, BRAIN RES, V1309, P83, DOI 10.1016/j.brainres.2009.09.120
   Jensen L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061952
   Jiang YH, 2004, AM J MED GENET A, V131A, P1, DOI 10.1002/ajmg.a.30297
   Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6
   Kishino T, 1997, NAT GENET, V15, P70, DOI 10.1038/ng0197-70
   Kleijnen MF, 2000, MOL CELL, V6, P409, DOI 10.1016/S1097-2765(00)00040-X
   Kuhnle S, 2013, P NATL ACAD SCI USA, V110, P8888, DOI 10.1073/pnas.1302792110
   Lipinszki Z, 2009, J CELL SCI, V122, P3083, DOI 10.1242/jcs.049049
   Low Hai Loon C-F, 2012, ADV TOPICS NEUROLOGI
   Lu YB, 2009, HUM MOL GENET, V18, P454, DOI 10.1093/hmg/ddn373
   Margolis SS, 2010, CELL, V143, P442, DOI 10.1016/j.cell.2010.09.038
   Martinez-Noel G, 2012, MOL CELL BIOL, V32, P3095, DOI 10.1128/MCB.00201-12
   Martins-de-Souza D, 2009, J NEURAL TRANSM, V116, P275, DOI 10.1007/s00702-008-0156-y
   Matsuura T, 1997, NAT GENET, V15, P74, DOI 10.1038/ng0197-74
   Min MW, 2013, OPEN BIOL, V3, DOI 10.1098/rsob.130097
   Mishra A, 2009, NEUROBIOL DIS, V36, P26, DOI 10.1016/j.nbd.2009.06.010
   Puram SV, 2013, CELL REP, V4, P19, DOI 10.1016/j.celrep.2013.06.006
   Reiter LT, 2006, HUM MOL GENET, V15, P2825, DOI 10.1093/hmg/ddl225
   Sato M, 2010, P NATL ACAD SCI USA, V107, P5611, DOI 10.1073/pnas.1001281107
   Scanlon TC, 2009, EXP CELL RES, V315, P176, DOI 10.1016/j.yexcr.2008.10.027
   Schanen NC, 2006, HUM MOL GENET, V15, pR138, DOI 10.1093/hmg/ddl213
   Shen H, 2007, J NEUROSCI, V27, P8903, DOI 10.1523/JNEUROSCI.1571-07.2007
   Smith SEP, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002627
   Szlanka T, 2003, J CELL SCI, V116, P1023, DOI 10.1242/jcs.00332
   Tai HC, 2010, FRONT MOL NEUROSCI, V3, P12, DOI DOI 10.3389/FNM0L.2010.00012
   Takagi Y, 1998, NEUROSCI LETT, V244, P149, DOI 10.1016/S0304-3940(98)00145-1
   UI K, 1994, IN VITRO CELL DEV-AN, V30A, P209
   Urraca N, 2013, AUTISM RES, V6, P268, DOI 10.1002/aur.1284
   Wang M, 2005, EMBO J, V24, P4324, DOI 10.1038/sj.emboj.7600895
   Wang XR, 2007, BIOCHEMISTRY-US, V46, P3553, DOI 10.1021/bi061994u
   Williams CA, 2005, BRAIN DEV-JPN, V27, P88, DOI 10.1016/j.braindev.2003.09.014
   Wu Y, 2008, P NATL ACAD SCI USA, V105, P12399, DOI 10.1073/pnas.0805291105
   Yao TT, 2006, NAT CELL BIOL, V8, P994, DOI 10.1038/ncb1450
NR 46
TC 1
Z9 1
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD JUL
PY 2014
VL 71
IS 14
BP 2747
EP 2758
DI 10.1007/s00018-013-1526-7
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AK0SW
UT WOS:000338126600012
PM 24292889
ER

PT J
AU Tyszka, JM
   Kennedy, DP
   Paul, LK
   Adolphs, R
AF Tyszka, J. Michael
   Kennedy, Daniel P.
   Paul, Lynn K.
   Adolphs, Ralph
TI Largely Typical Patterns of Resting-State Functional Connectivity in
   High-Functioning Adults with Autism
SO CEREBRAL CORTEX
LA English
DT Article
DE autism spectrum disorder; functional magnetic resonance imaging;
   independent component analysis; resting-state networks; temporal
   correlation
ID SPECTRUM DISORDERS; BRAIN CONNECTIVITY; PUBLICATION BIAS;
   CORPUS-CALLOSUM; WORKING-MEMORY; NETWORKS; CORTEX; FMRI; MRI;
   UNDERCONNECTIVITY
AB A leading hypothesis for the neural basis of autism postulates globally abnormal brain connectivity, yet the majority of studies report effects that are either very weak, inconsistent across studies, or explain results incompletely. Here we apply multiple analytical approaches to resting-state BOLD-fMRI data at the whole-brain level. Neurotypical and high-functioning adults with autism displayed very similar patterns and strengths of resting-state connectivity. We found only limited evidence in autism for abnormal resting-state connectivity at the regional level and no evidence for altered connectivity at the whole-brain level. Regional abnormalities in functional connectivity in autism spectrum disorder were primarily in the frontal and temporal cortices. Within these regions, functional connectivity with other brain regions was almost exclusively lower in the autism group. Further examination showed that even small amounts of head motion during scanning have large effects on functional connectivity measures and must be controlled carefully. Consequently, we suggest caution in the interpretation of apparent positive findings until all possible confounding effects can be ruled out. Additionally, we do not rule out the possibility that abnormal connectivity in autism is evident at the microstructural synaptic level, which may not be reflected sensitively in hemodynamic changes measured with BOLD-fMRI.
C1 [Tyszka, J. Michael; Adolphs, Ralph] CALTECH, Div Biol, Pasadena, CA 91125 USA.
   [Kennedy, Daniel P.; Paul, Lynn K.; Adolphs, Ralph] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
   [Kennedy, Daniel P.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA.
RP Tyszka, JM (reprint author), CALTECH, 2A Broad 114-96,1200 E Calif Blvd, Pasadena, CA 91125 USA.
EM jmt@caltech.edu; dpk@indiana.edu
RI Tyszka, Julian/O-3498-2014
OI Tyszka, Julian/0000-0001-9342-9014
FU National Institutes of Health [P50MH094258, R01 MH080721,
   K99MH094409/R00MH094409]; Simons Foundation [SFARI-07-01]; National
   Alliance for Research on Schizophrenia and Depression (Young
   Investigator Award)
FX This work was supported by a Conte Center grant from the National
   Institutes of Health (P50MH094258 to R. A., J.M.T., L. K. P.) and grants
   from the Simons Foundation (SFARI-07-01 to R. A.), the National
   Institutes of Health (R01 MH080721 to R. A.; K99MH094409/R00MH094409 to
   D. P. K.), and the National Alliance for Research on Schizophrenia and
   Depression (2009 Young Investigator Award to L.K.P.).
CR Abell F, 1999, NEUROREPORT, V10, P1647, DOI 10.1097/00001756-199906030-00005
   Andersen LMJ, 2011, J AUTISM DEV DISORD, V41, P1635, DOI 10.1007/s10803-011-1191-3
   Anderson Jeffrey S, 2011, Brain, V134, P3742, DOI 10.1093/brain/awr263
   Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
   Andersson J., 2008, 14 ANN M ORG HUM BRA
   Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Beckmann CF, 2004, IEEE T MED IMAGING, V23, P137, DOI 10.1109/TMI.2003.822821
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Bennett CM, 2009, SOC COGN AFFECT NEUR, V4, P417, DOI 10.1093/scan/nsp053
   Biswal BB, 2010, P NATL ACAD SCI USA, V107, P4734, DOI 10.1073/pnas.0911855107
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Calhoun VD, 2001, HUM BRAIN MAPP, V14, P140, DOI 10.1002/hbm.1048
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   Damiano CR, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-13
   Damoiseaux JS, 2006, P NATL ACAD SCI USA, V103, P13848, DOI 10.1073/pnas.0601417103
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Filippini N, 2009, P NATL ACAD SCI USA, V106, P7209, DOI 10.1073/pnas.0811879106
   Fox MD, 2009, J NEUROPHYSIOL, V101, P3270, DOI 10.1152/jn.90777.2008
   Garber K, 2007, SCIENCE, V317, P190, DOI 10.1126/science.317.5835.190
   Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Gotts SJ, 2012, BRAIN, V135, P2711, DOI 10.1093/brain/aws160
   Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
   Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
   Hinsby AM, 2006, MOL CELL, V22, P285, DOI 10.1016/j.molcel.2006.03.012
   Jennings RG, 2012, NEUROINFORMATICS, V10, P67, DOI 10.1007/s12021-011-9125-y
   Joel SE, 2011, MAGN RESON MED, V66, P644, DOI 10.1002/mrm.22818
   Johnson RT, 2007, NAT CLIN PRACT NEURO, V3, P590, DOI 10.1038/ncpneuro0618
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kelly RE, 2010, J NEUROSCI METH, V189, P233, DOI 10.1016/j.jneumeth.2010.03.028
   Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Lee M, 2002, BRAIN, V125, P1483, DOI 10.1093/brain/awf160
   Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
   Lin A, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-8
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MacKenzie-Graham Allan, 2007, Methods Mol Biol, V401, P183, DOI 10.1007/978-1-59745-520-6_11
   Madsen KM, 2003, PEDIATRICS, V112, P604, DOI 10.1542/peds.112.3.604
   Madsen Kreesten Meldgaard, 2004, Ugeskr Laeger, V166, P3291
   Mazaika PK, 2005, DETECTION REPAIR TRA
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   RADEMACHER J, 1992, J COGNITIVE NEUROSCI, V4, P352, DOI 10.1162/jocn.1992.4.4.352
   Sbacchi S, 2010, CURR GENOMICS, V11, P136, DOI 10.2174/138920210790886880
   Shirer WR, 2012, CEREB CORTEX, V22, P158, DOI 10.1093/cercor/bhr099
   Smith SM, 2009, P NATL ACAD SCI USA, V106, P13040, DOI 10.1073/pnas.0905267106
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Stevens WD, 2010, CEREB CORTEX, V20, P1997, DOI 10.1093/cercor/bhp270
   Tyszka JM, 2011, J NEUROSCI, V31, P15154, DOI 10.1523/JNEUROSCI.1453-11.2011
   Van Dijk KRA, 2010, J NEUROPHYSIOL, V103, P297, DOI 10.1152/jn.00783.2009
   Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   von dem Hagen EA, 2012, SOC COGN AFFECT NEUR
   von dem Hagen EAH, 2011, CEREB CORTEX, V21, P493, DOI 10.1093/cercor/bhq062
   Waites AB, 2005, HUM BRAIN MAPP, V24, P59, DOI 10.1002/hbm.20069
   Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042
   Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
   Zhang YY, 2001, IEEE T MED IMAGING, V20, P45, DOI 10.1109/42.906424
NR 70
TC 12
Z9 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD JUL
PY 2014
VL 24
IS 7
BP 1894
EP 1905
DI 10.1093/cercor/bht040
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA AK0NS
UT WOS:000338110900017
PM 23425893
ER

PT J
AU Travis, KE
   Curran, MM
   Torres, C
   Leonard, MK
   Brown, TT
   Dale, AM
   Elman, JL
   Halgren, E
AF Travis, Katherine E.
   Curran, Megan M.
   Torres, Christina
   Leonard, Matthew K.
   Brown, Timothy T.
   Dale, Anders M.
   Elman, Jeffrey L.
   Halgren, Eric
TI Age-related Changes in Tissue Signal Properties Within Cortical Areas
   Important for Word Understanding in 12-to 19-Month-Old Infants
SO CEREBRAL CORTEX
LA English
DT Article
DE brain development; infants; language; structural MRI
ID HUMAN CEREBRAL-CORTEX; NERVOUS-SYSTEM MYELINATION; AUTISM SPECTRUM
   DISORDERS; NORMAL BRAIN-DEVELOPMENT; SURFACE-BASED ANALYSIS;
   HIGH-RESOLUTION MRI; GRAY-MATTER; MORPHOMETRIC-ANALYSIS; IRON
   CONCENTRATION; T2-WEIGHTED MRI
AB Recently, our laboratory has shown that the neural mechanisms for encoding lexico-semantic information in adults operate functionally by 12-18 months of age within left frontotemporal cortices (Travis et al., 2011. Spatiotemporal neural dynamics of word understanding in 12- to 18-month-old-infants. Cereb Cortex. 8:1832-1839). However, there is minimal knowledge of the structural changes that occur within these and other cortical regions important for language development. To identify regional structural changes taking place during this important period in infant development, we examined age-related changes in tissue signal properties of gray matter (GM) and white matter (WM) intensity and contrast. T-1-weighted surface-based measures were acquired from 12- to 19-month-old infants and analyzed using a general linear model. Significant age effects were observed for GM and WM intensity and contrast within bilateral inferior lateral and anterovental temporal regions, dorsomedial frontal, and superior parietal cortices. Region of interest (ROI) analyses revealed that GM and WM intensity and contrast significantly increased with age within the same left lateral temporal regions shown to generate lexico-semantic activity in infants and adults. These findings suggest that neurophysiological processes supporting linguistic and cognitive behaviors may develop before cellular and structural maturation is complete within associative cortices. These results have important implications for understanding the neurobiological mechanisms relating structural to functional brain development.
C1 [Travis, Katherine E.; Curran, Megan M.; Torres, Christina; Leonard, Matthew K.; Dale, Anders M.; Halgren, Eric] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA.
   [Travis, Katherine E.; Curran, Megan M.; Torres, Christina; Leonard, Matthew K.; Brown, Timothy T.; Dale, Anders M.; Halgren, Eric] Univ Calif San Diego, Multimodal Imaging Lab, San Diego, CA 92103 USA.
   [Brown, Timothy T.; Dale, Anders M.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
   [Elman, Jeffrey L.; Halgren, Eric] Univ Calif San Diego, Kavli Inst Brain & Mind, San Diego, CA 92103 USA.
   [Elman, Jeffrey L.] Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92103 USA.
RP Travis, KE (reprint author), Stanford Univ, Dept Pediat, Sch Med, Grant Bldg S-224, Stanford, CA 94305 USA.
EM ktravis1@stanford.edu
FU Kavli Institute for Brain and Mind, UCSD; NIH/NINDA [R01 NS018741-23A1,
   R21 HD066364]; NIH; Chancellor's Collaboratories Award, UCSD
FX Funding sources include Kavli Institute for Brain and Mind, UCSD
   http://kibm.ucsd.edu/ and NIH/NINDA R01 NS018741-23A1, R21 HD066364
   funding of E. H. K. E. T and M. K. L. have been supported by NIH
   pre-doctoral training grants and the Chancellor's Collaboratories Award,
   UCSD. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR Almli CR, 2007, NEUROIMAGE, V35, P308, DOI 10.1016/j.neuroimage.2006.08.058
   BARKOVICH AJ, 1988, RADIOLOGY, V166, P173
   Barkovich AJ, 2000, AM J NEURORADIOL, V21, P1099
   Bates E, 1992, HDB NEUROPSYCHOLOGY
   Binder JR, 2009, CEREB CORTEX, V19, P2767, DOI 10.1093/cercor/bhp055
   BRODY BA, 1987, J NEUROPATH EXP NEUR, V46, P283, DOI 10.1097/00005072-198705000-00005
   Brown TT, 2012, CURR BIOL, V22, P1693, DOI 10.1016/j.cub.2012.07.002
   Casey BJ, 2005, TRENDS COGN SCI, V9, P104, DOI 10.1016/j.tics.2005.01.011
   Choe MS, 2013, CEREB CORTEX, V23, P2100, DOI 10.1093/cercor/bhs197
   Chugani HT, 1998, PREV MED, V27, P184, DOI 10.1006/pmed.1998.0274
   Conel JL, 1955, POSTNATAL DEV HUMAN
   Connor JR, 1996, GLIA, V17, P83, DOI 10.1002/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7
   Courchesne E, 2000, RADIOLOGY, V216, P672
   Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
   Deoni SCL, 2011, METHODS MOL BIOL, V711, P65, DOI 10.1007/978-1-61737-992-5_4
   Desikan RS, 2006, NEUROIMAGE, V31, P968, DOI 10.1016/j.neuroimage.2006.01.021
   DOBBING J, 1973, ARCH DIS CHILD, V48, P757
   Eickhoff S, 2005, HUM BRAIN MAPP, V24, P206, DOI 10.1002/hbm.20082
   Fenson L., 1994, MONOGRAPHS SOC RES C, V59
   Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
   Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
   Flechsig PE, 1920, ANATOMIC MENSCHLICHE, V1
   Gao W, 2009, AM J NEURORADIOL, V30, P290, DOI 10.3174/ajnr.A1363
   Gelman N, 2001, MAGNET RESON MED, V45, P71, DOI 10.1002/1522-2594(200101)45:1<71::AID-MRM1011>3.0.CO;2-2
   Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
   Giedd JN, 1996, CEREB CORTEX, V6, P551, DOI 10.1093/cercor/6.4.551
   Gilmore J, 2011, CEREB CORTEX, V22, P2478
   Gilmore JH, 2007, J NEUROSCI, V27, P1255, DOI 10.1523/JNEUROSCI.3339-06.2007
   Glasser MF, 2011, J NEUROSCI, V31, P11597, DOI 10.1523/JNEUROSCI.2180-11.2011
   HALLGREN B, 1958, J NEUROCHEM, V3, P41, DOI 10.1111/j.1471-4159.1958.tb12607.x
   Herschkowitz N, 1999, NEUROPEDIATRICS, V30, P221, DOI 10.1055/s-2007-973495
   HUTTENLOCHER PR, 1987, HUM NEUROBIOL, V6, P1
   Huttenlocher PR, 1997, J COMP NEUROL, V387, P167, DOI 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
   KINNEY HC, 1988, J NEUROPATH EXP NEUR, V47, P217, DOI 10.1097/00005072-198805000-00003
   Knickmeyer RC, 2008, J NEUROSCI, V28, P12176, DOI 10.1523/JNEUROSCI.3479-08.2008
   Kutas M, 2011, ANNU REV PSYCHOL, V62, P621, DOI 10.1146/annurev.psych.093008.131123
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Lu LH, 2007, CEREB CORTEX, V17, P1092, DOI 10.1093/cercor/bhl019
   Moore JK, 2001, JARO, V2, P297, DOI 10.1007/s101620010052
   O'Donnell S, 2005, NEUROIMAGE, V24, P948, DOI 10.1016/j.neuroimage.2004.10.014
   Ogg RJ, 1998, MAGNET RESON MED, V40, P749, DOI 10.1002/mrm.1910400516
   Ortiz-Mantilla S, 2010, NEUROIMAGE, V49, P2791, DOI 10.1016/j.neuroimage.2009.10.029
   Petanjek Z, 2008, CEREB CORTEX, V18, P915, DOI 10.1093/cercor/bhm124
   Petanjek Z, 2012, P NATL ACAD SCI USA, V108, P13281
   PFEFFERBAUM A, 1994, ARCH NEUROL-CHICAGO, V51, P874
   Pfluger T, 1999, EPILEPSIA, V40, P414, DOI 10.1111/j.1528-1157.1999.tb00735.x
   Reiss AL, 1996, BRAIN, V119, P1763, DOI 10.1093/brain/119.5.1763
   Salat DH, 2009, NEUROIMAGE, V48, P21, DOI 10.1016/j.neuroimage.2009.06.074
   SCHAEFER GB, 1990, J CHILD NEUROL, V5, P127
   Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008
   Sowell ER, 2004, NEUROSCIENTIST, V10, P372, DOI 10.1177/1073858404263960
   Sowell ER, 2002, DEV MED CHILD NEUROL, V44, P4, DOI 10.1017/S0012162201001591
   Sowell ER, 2004, J NEUROSCI, V24, P8223, DOI 10.1523/JNEUROSCI.1798-04.2004
   Sowell ER, 2007, CEREB CORTEX, V17, P1550, DOI 10.1093/cercor/bhl066
   Sowell ER, 2001, J NEUROSCI, V21, P8819
   Steen RG, 2000, MAGN RESON IMAGING, V18, P361, DOI 10.1016/S0730-725X(00)00123-5
   Tau GZ, 2010, NEUROPSYCHOPHARMACOL, V35, P147, DOI 10.1038/npp.2009.115
   Thompson PM, 2000, NATURE, V404, P190
   Toga AW, 2006, TRENDS NEUROSCI, V29, P148, DOI 10.1016/j.tins.2006.01.007
   Travis K, 2005, DEV NEUROSCI-BASEL, V27, P277, DOI 10.1159/000086707
   Travis KE, 2011, CEREB CORTEX, V21, P1832, DOI 10.1093/cercor/bhq259
   Utsunomiya H, 1999, AM J NEURORADIOL, V20, P717
   VYMAZAL J, 1995, JMRI-J MAGN RESON IM, V5, P554
   Vymazal J, 1996, MAGN RESON MED, V35, P56, DOI 10.1002/mrm.1910350108
   Walters NB, 2003, P NATL ACAD SCI USA, V100, P2981, DOI 10.1073/pnas.0437891600
   Westlye LT, 2010, NEUROIMAGE, V52, P172, DOI 10.1016/j.neuroimage.2010.03.056
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Yakovlev P. I., 1967, REGIONAL DEV BRAIN E, P3
   Zilles K, 1986, ANAT EMBYROL, V174, P329
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 70
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD JUL
PY 2014
VL 24
IS 7
BP 1948
EP 1955
DI 10.1093/cercor/bht052
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA AK0NS
UT WOS:000338110900021
PM 23448869
ER

PT J
AU de Klerk, CCJM
   Gliga, T
   Charman, T
   Johnson, MH
AF de Klerk, Carina C. J. M.
   Gliga, Teodora
   Charman, Tony
   Johnson, Mark H.
CA BASIS Team
TI Face engagement during infancy predicts later face recognition ability
   in younger siblings of children with autism
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID SPECTRUM DISORDERS; DEVELOPMENTAL DISORDERS; VISUAL-ATTENTION;
   GAZE-FIXATION; HIGH-RISK; INDIVIDUALS; TODDLERS; PERCEPTION; DIAGNOSIS;
   CIRCUITRY
AB Face recognition difficulties are frequently documented in children with autism spectrum disorders (ASD). It has been hypothesized that these difficulties result from a reduced interest in faces early in life, leading to decreased cortical specialization and atypical development of the neural circuitry for face processing. However, a recent study by our lab demonstrated that infants at increased familial risk for ASD, irrespective of their diagnostic status at 3 years, exhibit a clear orienting response to faces. The present study was conducted as a follow-up on the same cohort to investigate how measures of early engagement with faces relate to face-processing abilities later in life. We also investigated whether face recognition difficulties are specifically related to an ASD diagnosis, or whether they are present at a higher rate in all those at familial risk. At 3 years we found a reduced ability to recognize unfamiliar faces in the high-risk group that was not specific to those children who received an ASD diagnosis, consistent with face recognition difficulties being an endophenotype of the disorder. Furthermore, we found that longer looking at faces at 7 months was associated with poorer performance on the face recognition task at 3 years in the high-risk group. These findings suggest that longer looking at faces in infants at risk for ASD might reflect early face-processing difficulties and predicts difficulties with recognizing faces later in life.
C1 [de Klerk, Carina C. J. M.; Gliga, Teodora; Johnson, Mark H.] Univ London, Birbeck Coll, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
   [Charman, Tony] Kings Coll London, Inst Psychiat, London, England.
RP de Klerk, CCJM (reprint author), Univ London, Birbeck Coll, Ctr Brain & Cognit Dev, Henry Wellcome Bldg, London WC1E 7HX, England.
EM c.deklerk@bbk.ac.uk
RI Pickles, Andrew/A-9625-2011
OI Pickles, Andrew/0000-0003-1283-0346
CR Adolphs R, 2008, CURR BIOL, V18, P1090, DOI 10.1016/j.cub.2008.06.073
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Barton JJS, 2004, BRAIN, V127, P1706, DOI 10.1093/brain/awh194
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
   Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
   Chawarska K, 2013, BIOL PSYCHIAT, V74, P195, DOI 10.1016/j.biopsych.2012.11.022
   Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
   Chawarska K, 2007, DEVELOPMENTAL SCI, V10, P266, DOI 10.1111/j.1467-7687.2006.00543.x
   COLOMBO J, 1991, CHILD DEV, V62, P1247, DOI 10.1111/j.1467-8624.1991.tb01603.x
   Constantino JN, 2010, J NEURODEV DISORD, V2, P39, DOI 10.1007/s11689-009-9036-5
   Dalton KM, 2007, BIOL PSYCHIAT, V61, P512, DOI 10.1016/j.biopsych.2006.05.019
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   DAVIES S, 1994, J CHILD PSYCHOL PSYC, V35, P1033, DOI 10.1111/j.1469-7610.1994.tb01808.x
   Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
   Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
   De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220
   Elsabbagh M, 2013, BEHAV BRAIN RES, V251, P147, DOI 10.1016/j.bbr.2012.07.030
   Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
   Elsabbagh M, 2014, SOC COGN AFFECT NEUR, V9, P538, DOI 10.1093/scan/nst012
   Falck-Ytter T, 2008, AUTISM RES, V1, P297, DOI 10.1002/aur.45
   Gliga T, 2009, INFANCY, V14, P550, DOI 10.1080/15250000903144199
   Golarai G, 2006, CLIN NEUROSCI RES, V6, P145, DOI 10.1016/j.cnr.2006.08.001
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028
   Halit H, 2004, J CHILD PSYCHOL PSYC, V45, P1228, DOI 10.1111/j.1469-7610.2004.00321.x
   Hauck M, 1998, CHILD NEUROPSYCHOL, V4, P187, DOI 10.1076/chin.4.3.187.3174
   Henderson JM, 2005, MEM COGNITION, V33, P98, DOI 10.3758/BF03195300
   HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
   Johnson MH, 2005, NAT REV NEUROSCI, V6, P766, DOI 10.1038/nrn1766
   Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
   Key APF, 2012, DEV COGN NEUROS-NETH, V2, P244, DOI 10.1016/j.dcn.2011.12.003
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   McCleery JP, 2009, BIOL PSYCHIAT, V66, P950, DOI 10.1016/j.biopsych.2009.07.031
   Merin N., 2006, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4
   MORTON J, 1991, PSYCHOL REV, V98, P164, DOI 10.1037//0033-295X.98.2.164
   Mullen E, 1995, MULLEN SCALES EARLY
   Nelson CA, 2001, INFANT CHILD DEV, V10, P3, DOI 10.1002/icd.239
   Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Paul R, 2011, J CHILD PSYCHOL PSYC, V52, P588, DOI 10.1111/j.1469-7610.2010.02332.x
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Pickles A, 2000, J CHILD PSYCHOL PSYC, V41, P491, DOI 10.1017/S0021963099005557
   Quinn PC, 2009, INFANCY, V14, P474, DOI 10.1080/15250000902994248
   Saint-Georges C, 2010, RES AUTISM SPECT DIS, V4, P355, DOI 10.1016/j.rasd.2009.10.017
   Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Schwarzer G, 2007, DEVELOPMENTAL SCI, V10, P452, DOI 10.1111/j.1467-7687.2007.00599.x
   van Asselen M., 2012, FRONT PSYCHOL, V3, P1
   Wallace S, 2010, AUTISM RES, V3, P345, DOI 10.1002/aur.161
   Webb SJ, 2010, CHILD NEUROPSYCHOL, V16, P255, DOI 10.1080/09297041003601454
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
   Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
   Zhu Q, 2010, CURR BIOL, V20, P137, DOI 10.1016/j.cub.2009.11.067
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
NR 64
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1363-755X
EI 1467-7687
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD JUL
PY 2014
VL 17
IS 4
BP 596
EP 611
DI 10.1111/desc.12141
PG 16
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA AK0OU
UT WOS:000338114300009
PM 24314028
ER

PT J
AU Bedford, R
   Pickles, A
   Gliga, T
   Elsabbagh, M
   Charman, T
   Johnson, MH
AF Bedford, Rachael
   Pickles, Andrew
   Gliga, Teodora
   Elsabbagh, Mayada
   Charman, Tony
   Johnson, Mark H.
CA BASIS Team
TI Additive effects of social and non-social attention during infancy
   relate to later autism spectrum disorder
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID JOINT VISUAL-ATTENTION; CHILDREN; COMMUNICATION; DISENGAGEMENT; BEHAVIOR
AB Emerging findings from studies with infants at familial high risk for autism spectrum disorder (ASD), owing to an older sibling with a diagnosis, suggest that those who go on to develop ASD show early impairments in the processing of stimuli with both social and non-social content. Although ASD is defined by social-communication impairments and restricted and repetitive behaviours, the majority of cognitive theories of ASD posit a single underlying factor, which over development has secondary effects across domains. This is the first high-risk study to statistically differentiate theoretical models of the development of ASD in high-risk siblings using multiple risk factors. We examined the prediction of ASD outcome by attention to social and non-social stimuli: gaze following and attentional disengagement assessed at 13 months in low-risk controls and high-risk ASD infants (who were subsequently diagnosed with ASD at 3 years). When included in the same regression model, these 13-month measures independently predicted ASD outcome at 3 years of age. The data were best described by an additive model, suggesting that non-social attention, disengagement, and social attention as evidenced by gaze following, have a cumulative impact on ASD risk. These data argue against cognitive theories of ASD which propose that a single underlying factor has cascading effects across early development leading to an ASD outcome, and support multiple impairment models of ASD that are more consistent with recent genetic and neurobiological evidence.
C1 [Bedford, Rachael; Pickles, Andrew; Charman, Tony] Kings Coll London, Inst Psychiat, Dept Biostat, London SE5 8AF, England.
   [Gliga, Teodora; Johnson, Mark H.] Univ London, Ctr Brain & Cognit Dev, Birkbeck, London WC1E 7HU, England.
   [Elsabbagh, Mayada] McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T5, Canada.
RP Bedford, R (reprint author), Kings Coll London, Inst Psychiat, Dept Biostat, P020,Decrespigny Pk, London SE5 8AF, England.
EM rachael.bedford@kcl.ac.uk
RI Pickles, Andrew/A-9625-2011
OI Pickles, Andrew/0000-0003-1283-0346
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bedford R, 2012, J AUTISM DEV DISORD, V42, P2208, DOI 10.1007/s10803-012-1450-y
   Brooks R, 2002, DEV PSYCHOL, V38, P958, DOI 10.1037//0012-1649.38.6.958
   Brooks R, 2005, DEVELOPMENTAL SCI, V8, P535, DOI 10.1111/j.1467-7687.2005.00445.x
   BUTTERWORTH G, 1991, BRIT J DEV PSYCHOL, V9, P55
   Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
   Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x
   Elsabbagh M, 2013, BIOL PSYCHIAT, V74, P189, DOI 10.1016/j.biopsych.2012.11.030
   Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
   Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
   Farroni T, 2004, INFANCY, V5, P39, DOI 10.1207/s15327078in0501_2
   Fischer B, 1997, BRAIN RES PROTOC, V2, P47, DOI 10.1016/S1385-299X(97)00027-5
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
   Karmiloff-Smith A, 2006, COGN AFFECT BEHAV NE, V6, P9, DOI 10.3758/CABN.6.1.9
   Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
   Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261
   Mullen E, 1995, MULLEN SCALES EARLY
   Ozonoff S., 2011, PEDIATRICS, V128, P488, DOI DOI 10.1542/PEDS.2010-2825
   Pickles A., 1993, PRECURSORS CAUSES DE, P23
   Pickles A., 2007, METHODS LIFE COURSE, P221
   POSNER MI, 1980, Q J EXP PSYCHOL, V32, P3, DOI 10.1080/00335558008248231
   Presmanes AG, 2007, J AUTISM DEV DISORD, V37, P133, DOI 10.1007/s10803-006-0338-0
   Rabe- Hesketh S., 2004, BERKELEY DIVISION BI, P160
   Rozga A, 2011, J AUTISM DEV DISORD, V41, P287, DOI 10.1007/s10803-010-1051-6
   SCAIFE M, 1975, NATURE, V253, P265, DOI 10.1038/253265a0
   Senju A, 2008, CURR BIOL, V18, P668, DOI 10.1016/j.cub.2008.03.059
   Sjowall D., 2012, J CHILD PSYCHOL PSYC, V54, P619
   Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
   WING L, 1971, J AUTISM CHILD SCHIZ, V1, P256, DOI 10.1007/BF01557347
   World Health Organization, 1993, MENT DIS GLOSS GUID
   Yoder P, 2009, J AUTISM DEV DISORD, V39, P1381, DOI 10.1007/s10803-009-0753-0
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 34
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1363-755X
EI 1467-7687
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD JUL
PY 2014
VL 17
IS 4
BP 612
EP 620
DI 10.1111/desc.12139
PG 9
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA AK0OU
UT WOS:000338114300010
PM 25089324
ER

PT J
AU Helbig, I
   Swinkels, MEM
   Aten, E
   Caliebe, A
   van 't Slot, R
   Boor, R
   von Spiczak, S
   Muhle, H
   Jahn, JA
   van Binsbergen, E
   van Nieuwenhuizen, O
   Jansen, FE
   Braun, KPJ
   de Haan, GJ
   Tommerup, N
   Stephani, U
   Hjalgrim, H
   Poot, M
   Lindhout, D
   Brilstra, EH
   Moller, RS
   Koeleman, BPC
AF Helbig, Ingo
   Swinkels, Marielle E. M.
   Aten, Emmelien
   Caliebe, Almuth
   van 't Slot, Ruben
   Boor, Rainer
   von Spiczak, Sarah
   Muhle, Hiltrud
   Jaehn, Johanna A.
   van Binsbergen, Ellen
   van Nieuwenhuizen, Onno
   Jansen, Floor E.
   Braun, Kees P. J.
   de Haan, Gerrit-Jan
   Tommerup, Niels
   Stephani, Ulrich
   Hjalgrim, Helle
   Poot, Martin
   Lindhout, Dick
   Brilstra, Eva H.
   Moller, Rikke S.
   Koeleman, Bobby P. C.
TI Structural genomic variation in childhood epilepsies with complex
   phenotypes
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE CNV; structural genomic variation; childhood epilepsies; epileptic
   encephalopathies
ID TERMINAL DELETION SYNDROME; MOLECULAR CHARACTERIZATION; 16P13.11
   PREDISPOSE; CLASSIFICATION; MICRODELETIONS; AUTISM
AB A genetic contribution to a broad range of epilepsies has been postulated, and particularly copy number variations (CNVs) have emerged as significant genetic risk factors. However, the role of CNVs in patients with epilepsies with complex phenotypes is not known. Therefore, we investigated the role of CNVs in patients with unclassified epilepsies and complex phenotypes. A total of 222 patients from three European countries, including patients with structural lesions on magnetic resonance imaging (MRI), dysmorphic features, and multiple congenital anomalies, were clinically evaluated and screened for CNVs. MRI findings including acquired or developmental lesions and patient characteristics were subdivided and analyzed in subgroups. MRI data were available for 88.3% of patients, of whom 41.6% had abnormal MRI findings. Eighty-eight rare CNVs were discovered in 71 out of 222 patients (31.9%). Segregation of all identified variants could be assessed in 42 patients, 11 of which were de novo. The frequency of all structural variants and de novo variants was not statistically different between patients with or without MRI abnormalities or MRI subcategories. Patients with dysmorphic features were more likely to carry a rare CNV. Genome-wide screening methods for rare CNVs may provide clues for the genetic etiology in patients with a broader range of epilepsies than previously anticipated, including in patients with various brain anomalies detectable by MRI. Performing genome-wide screens for rare CNVs can be a valuable contribution to the routine diagnostic workup in patients with a broad range of childhood epilepsies.
C1 [Helbig, Ingo; Boor, Rainer; von Spiczak, Sarah; Muhle, Hiltrud; Jaehn, Johanna A.; Stephani, Ulrich] Univ Med Ctr Schleswig Holstein UKSH, Dept Neuropediat, D-24105 Kiel, Germany.
   [Swinkels, Marielle E. M.; van 't Slot, Ruben; van Binsbergen, Ellen; Poot, Martin; Lindhout, Dick; Brilstra, Eva H.; Koeleman, Bobby P. C.] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.
   [Swinkels, Marielle E. M.; de Haan, Gerrit-Jan; Lindhout, Dick] SEIN Epilepsy Inst Netherlands Fdn, Hoofddorp, Netherlands.
   [Aten, Emmelien] Leiden Univ, Med Ctr, Dept Med Genet, Leiden, Netherlands.
   [Caliebe, Almuth] Univ Med Ctr Schleswig Holstein UKSH, Dept Human Genet, D-24105 Kiel, Germany.
   [van Nieuwenhuizen, Onno; Jansen, Floor E.; Braun, Kees P. J.] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Clin Neurol, Utrecht, Netherlands.
   [Tommerup, Niels; Moller, Rikke S.] Wilhelm Johannsen Ctr Funct Genome Res, Copenhagen, Denmark.
   [Hjalgrim, Helle; Moller, Rikke S.] Danish Epilepsy Ctr, Dianalund, Denmark.
   [Hjalgrim, Helle; Moller, Rikke S.] Univ Southern Denmark, Inst Reg Hlth Serv Res, Odense, Denmark.
RP Helbig, I (reprint author), Univ Med Ctr Schleswig Holstein UKSH, Dept Neuropediat, Bldg 9,Arnold Heller St 3, D-24105 Kiel, Germany.
EM i.helbig@pedneuro.uni-kiel.de
RI Poot, Martin/F-9427-2010; Stephani, Ulrich/D-1004-2010
FU EuroEPINOMICS projects within the EUROCORES framework of the European
   Science Foundation; German Research Foundation (DFG HE) [5413/3-1]
FX We thank the patients and their parents for participation in this study.
   This project was supported by the EuroEPINOMICS projects within the
   EUROCORES framework of the European Science Foundation and funds of the
   German Research Foundation (DFG HE 5413/3-1).
CR Barkovich AJ, 2005, NEUROLOGY, V65, P1873, DOI 10.1212/01.wnl.0000183747.05269.2d
   Berg AT, 2010, EPILEPSIA, V51, P676, DOI 10.1111/j.1528-1167.2010.02522.x
   Catarino CB, 2011, EPILEPSIA, V52, P1388, DOI 10.1111/j.1528-1167.2011.03087.x
   Commission on Classification and Terminology of the International League Against Epilepsy, 1989, EPILEPSIA, V30, P389
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
   Elia M, 2006, EPILEPSIA, V47, P830, DOI 10.1111/j.1528-1167.2006.00522.x
   Fernandez TV, 2008, AM J MED GENET A, V146A, P2746, DOI 10.1002/ajmg.a.32533
   Hannes FD, 2009, J MED GENET, V46, P223, DOI 10.1136/jmg.2007.055202
   Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
   Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
   Helbig I, 2008, LANCET NEUROL, V7, P231, DOI 10.1016/S1474-4422(08)70039-5
   Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
   Malmgren H, 2007, AM J MED GENET A, V143A, P2143, DOI 10.1002/ajmg.a.31902
   Mefford HC, 2009, CURR OPIN GENET DEV, V19, P196, DOI 10.1016/j.gde.2009.04.003
   Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Poot M, 2011, CYTOGENET GENOME RES, V135, P228, DOI 10.1159/000334064
   Striano P, 2006, AM J MED GENET A, V140A, P1944, DOI 10.1002/ajmg.a.31435
   Van Houdt JKJ, 2012, NAT GENET, V44, P445, DOI 10.1038/ng.1105
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 21
TC 3
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD JUL
PY 2014
VL 22
IS 7
BP 896
EP 901
DI 10.1038/ejhg.2013.262
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AK3RP
UT WOS:000338342700011
PM 24281369
ER

PT J
AU Lee, H
   Lin, MCA
   Kornblum, HI
   Papazian, DM
   Nelson, SF
AF Lee, Hane
   Lin, Meng-chin A.
   Kornblum, Harley I.
   Papazian, Diane M.
   Nelson, Stanley F.
TI Exome sequencing identifies de novo gain of function missense mutation
   in KCND2 in identical twins with autism and seizures that slows
   potassium channel inactivation
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID CLOSED-STATE INACTIVATION; SPECTRUM DISORDER; K+ CHANNELS; YOUNG-ADULTS;
   ION CHANNELS; EPILEPSY; KV4.2; MODULATION; PROTEIN; INDIVIDUALS
AB Numerous studies and case reports show comorbidity of autism and epilepsy, suggesting some common molecular underpinnings of the two phenotypes. However, the relationship between the two, on the molecular level, remains unclear. Here, whole exome sequencing was performed on a family with identical twins affected with autism and severe, intractable seizures. A de novo variant was identified in the KCND2 gene, which encodes the Kv4.2 potassium channel. Kv4.2 is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current (I-SA) channels. The de novo mutation p.Val404Met is novel and occurs at a highly conserved residue within the C-terminal end of the transmembrane helix S6 region of the ion permeation pathway. Functional analysis revealed the likely pathogenicity of the variant in that the p.Val404Met mutant construct showed significantly slowed inactivation, either by itself or after equimolar coexpression with the wild-type Kv4.2 channel construct consistent with a dominant effect. Further, the effect of the mutation on closed-state inactivation was evident in the presence of auxiliary subunits that associate with Kv4 subunits to form I-SA channels in vivo. Discovery of a functionally relevant novel de novo variant, coupled with physiological evidence that the mutant protein disrupts potassium current inactivation, strongly supports KCND2 as the causal gene for epilepsy in this family. Interaction of KCND2 with other genes implicated in autism and the role of KCND2 in synaptic plasticity provide suggestive evidence of an etiological role in autism.
C1 [Lee, Hane; Nelson, Stanley F.] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA.
   [Lin, Meng-chin A.; Papazian, Diane M.] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA.
   [Kornblum, Harley I.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA.
   [Kornblum, Harley I.] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
   [Kornblum, Harley I.] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90095 USA.
   [Nelson, Stanley F.] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA.
RP Nelson, SF (reprint author), Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA.
EM snelson@ucla.edu
FU P30 UCLA Muscular Dystrophy Core Center grant; National Institutes of
   Health [5R01NS073871-03, 5R01GM043459-21]
FX The work was performed within the UCLA Clinical Genomics Center with
   support from the P30 UCLA Muscular Dystrophy Core Center grant to S.N.,
   National Institutes of Health grant 5R01NS073871-03 to S.N. and National
   Institutes of Health grant 5R01GM043459-21 to D.M.P.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Aad G, 2012, PHYS REV LETT, V108, DOI 10.1103/PhysRevLett.108.152001
   Bahlo M, 2009, BIOINFORMATICS, V25, P1961, DOI 10.1093/bioinformatics/btp313
   Bahring R, 2001, J PHYSIOL-LONDON, V535, P65, DOI 10.1111/j.1469-7793.2001.00065.x
   Bahring R, 2011, J PHYSIOL-LONDON, V589, P461, DOI 10.1113/jphysiol.2010.191965
   Barghaan J, 2009, J GEN PHYSIOL, V133, P205, DOI 10.1085/jgp.200810073
   Birnbaum SG, 2004, PHYSIOL REV, V84, P803, DOI 10.1152/00039.2003
   Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877
   Bouvrette DJ, 2008, NEPHRON EXP NEPHROL, V108, pE27, DOI 10.1159/000112913
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Covarrubias M, 2008, NEUROCHEM RES, V33, P1558, DOI 10.1007/s11064-008-9650-8
   Danielsson S, 2005, EPILEPSIA, V46, P918, DOI 10.1111/j.1528-1167.2005.57504.x
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
   Gebauer M, 2004, BIOPHYS J, V86, P210, DOI 10.1016/S0006-3495(04)74097-7
   Rossi PG, 2000, BRAIN DEV-JPN, V22, P102
   Girirajan S, 2013, AM J HUM GENET, V92, P221, DOI 10.1016/j.ajhg.2012.12.016
   HARPAZ Y, 1994, STRUCTURE, V2, P641, DOI 10.1016/S0969-2126(00)00065-4
   Jeon D, 2003, NEURON, V38, P965, DOI 10.1016/S0896-6273(03)00334-9
   Jerng HH, 2005, J PHYSIOL-LONDON, V568, P767, DOI 10.1113/jphysiol.2005.087858
   Jerng HH, 1999, J GEN PHYSIOL, V113, P641, DOI 10.1085/jgp.113.5.641
   Jerng HH, 2004, MOL CELL NEUROSCI, V27, P343, DOI 10.1016/j.men.2004.06.011
   Jerng HH, 2009, CHANNELS, V3, P448
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Kim E, 2012, J NEUROSCI, V32, P14427, DOI 10.1523/JNEUROSCI.2373-12.2012
   Kraus MRC, 2012, HUM MUTAT, V33, P86, DOI 10.1002/humu.21610
   Ku CS, 2013, MOL PSYCHIATR, V18, P141, DOI 10.1038/mp.2012.58
   Lee HY, 2011, NEURON, V72, P630, DOI 10.1016/j.neuron.2011.09.033
   Lerche H, 2001, AM J MED GENET, V106, P146, DOI 10.1002/ajmg.1582
   Lo-Castro A., 2013, BRAIN DEV
   Long SB, 2005, SCIENCE, V309, P897, DOI 10.1126/science.1116269
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Matsuo M, 2010, BRAIN DEV-JPN, V32, P759, DOI 10.1016/j.braindev.2010.05.005
   McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
   Mikhailov A., 2008, ANN M AM SOC HUM GEN
   Mullen E, 1995, MULLEN SCALES EARLY
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Okamoto N, 2011, AM J MED GENET A, V155A, P1568, DOI 10.1002/ajmg.a.34028
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   PAPAZIAN DM, 1991, NATURE, V349, P305, DOI 10.1038/349305a0
   Parikshak NN, 2013, CELL, V155, P1008, DOI 10.1016/j.cell.2013.10.031
   Perou Ruth, 2013, MMWR Surveill Summ, V62 Suppl 2, P1
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Saemundsen E, 2007, EPILEPSIA, V48, P1724, DOI 10.1111/j.1528-1167.2007.01150.x
   Scherer SW, 2003, SCIENCE, V300, P767, DOI 10.1126/science.1083423
   Serodio P, 1998, J NEUROPHYSIOL, V79, P1081
   Smith KR, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-9-r85
   Steffenburg S, 2003, DEV MED CHILD NEUROL, V45, P724, DOI 10.1017/S0012162203001361
   TIMPE LC, 1988, NATURE, V331, P143, DOI 10.1038/331143a0
   Wang HY, 2007, NAT NEUROSCI, V10, P32, DOI 10.1038/nn1822
   Wang SM, 2002, BIOCHEM BIOPH RES CO, V295, P223, DOI 10.1016/S0006-291X(02)00658-7
   Webster SM, 2004, NATURE, V428, P864, DOI 10.1038/nature02468
NR 55
TC 5
Z9 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD JUL
PY 2014
VL 23
IS 13
BP 3481
EP 3489
DI 10.1093/hmg/ddu056
PG 9
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AK0ST
UT WOS:000338126300011
PM 24501278
ER

EF